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<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SKG4</accession>
    <name>A0A8C2SKG4_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Kelch like family member 32</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">KLHL32</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SKG4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005000363.1">
        <property type="protein sequence ID" value="ENSCJPP00005000178.1"/>
        <property type="gene ID" value="ENSCJPG00005000260.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157179"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd18471">
        <property type="entry name" value="BACK_KLHL32_BKLHD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18261">
        <property type="entry name" value="BTB_POZ_KLHL32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056737">
        <property type="entry name" value="Beta-prop_ATRN-MKLN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017096">
        <property type="entry name" value="BTB-kelch_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030570">
        <property type="entry name" value="BTB_POZ_KLHL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047028">
        <property type="entry name" value="KLHL32_BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF3">
        <property type="entry name" value="KELCH-LIKE PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24981">
        <property type="entry name" value="Beta-prop_ATRN-LZTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037037">
        <property type="entry name" value="Kelch-like_protein_gigaxonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="42"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005000178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="636" mass="71911" checksum="3E47C49B00B7E064" modified="2022-01-19" version="1">MPSERCLSVQEMLTGQRLCQSSSHNDAVLAALNQQRSDGILCDITLIAEEQKFHAHKAVLAACSDYFRITSEVCSGVQKALSKQAMFSLCMVESEADEVNLHGVTSLGLKQALDFAYTGQILLEPGVIQDVLAAGSHLQLLELLSLCSHYLIQELNSFNYLDLYKLADLFNLTLLENAVVDFLVKHLSELLKSHPEEVLALPYCLLREVFKSDRLTSLSEEQIWQLAVRWLEHNCHYQYMDELLQYVRFGLMDVDTLHTVALSHPLVQASETATALVNEALAYHQSIYAQPVWQTRRTKPRFQSDTLYIIGGKKREICKVKELRYFNPVDQENVHIAGIANWSELAPMPMGRSHHCVAVMGDFLFVAGGEAEHSTGRTCAVRTACRYDPRTNSWAEIAPMKNCREHFVLGAVDEYLYAVGGRNELRQVLPTVERYCPKKNKWTFVQSFDRSLSCHAGYVVDGLLWISGGVTNTAQYQNRLMVYDPKQNKWLSRSPMLQRRVYHSMAAVQRKLYVLGGNDLDYNNDRILVRHIDSYSIDADQWTRCSFNMLTGQNESGVAVHNGRIYLVGGYSIWTNEPLACIQVLDVSKEGKEEVFYGPTLPFASNGIAACFLPAPYFTCPNLQTLQVPHHRMSTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SMI5</accession>
    <name>A0A8C2SMI5_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PAT1 homolog 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">PATL2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SMI5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005001716.1">
        <property type="protein sequence ID" value="ENSCJPP00005000981.1"/>
        <property type="gene ID" value="ENSCJPG00005001062.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00520000055649"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010607">
        <property type="term" value="P:negative regulation of cytoplasmic mRNA processing body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039900">
        <property type="entry name" value="Pat1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21551:SF3">
        <property type="entry name" value="PROTEIN PAT1 HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21551">
        <property type="entry name" value="TOPOISOMERASE II-ASSOCIATED PROTEIN PAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005000981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="443" mass="50015" checksum="2FFAF0AE66D9746A" modified="2022-01-19" version="1">EEPQDEGGTEPEVEQVGSEEEEEEDEEQGAEEQVDEEEPNDLGDPAVMRVVQSKPTLEVMPGWVMCQRSGRDALELLYRLQSSLSFCSVPSHLTQLHPQHQRILTQRQQQGGTVVSPKKQWSPKADPCAGLMTCKEKDWVIKVEMIQLQSENLDDDYYYQTYYHRLERKQAEEELLGGRNKQEPPKLVTPFIQKVETYNSVVRIAGSLGQVAVSTCYSPRRAIDAVHHALVEEVGEGDTSLQLFLQLLEVEEMQRKMSCAAEEQEEAEDEFLQVLCVRKGKKLTARLLPHLAPEQAEKILLTITHHLPFLMKKDVPDEASTSSLGHGVLGCFLLSLFLELAILTLPESAELPLTMALKNQFGISLLYSLLSRGEGLLSSEMPLEPHIGDFETWTDTVFLVARELSQVPKALLVEPLFLPSNLLSLFCRYLDKQTVHHLEAKME</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SNR2</accession>
    <name>A0A8C2SNR2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Protein disulfide-isomerase</fullName>
            <ecNumber evidence="13">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">PDIA3</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Melanosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="13"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2SNR2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005000860.1">
        <property type="protein sequence ID" value="ENSCJPP00005000467.1"/>
        <property type="gene ID" value="ENSCJPG00005000556.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155425"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042470">
        <property type="term" value="C:melanosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061779">
        <property type="term" value="C:Tapasin-ERp57 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106222">
        <property type="term" value="F:lncRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098761">
        <property type="term" value="P:cellular response to interleukin-7"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097191">
        <property type="term" value="P:extrinsic apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002502">
        <property type="term" value="P:peptide antigen assembly with MHC class I protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070527">
        <property type="term" value="P:platelet aggregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001238">
        <property type="term" value="P:positive regulation of extrinsic apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="CDD" id="cd02995">
        <property type="entry name" value="PDI_a_PDI_a'_C"/>
        <property type="match status" value="1"/>
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    <dbReference type="CDD" id="cd03073">
        <property type="entry name" value="PDI_b'_ERp72_ERp57"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PDI_b_ERp57"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Disulfide-isomerase A3"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Disulfide-isomerase A3"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Protein disulfide-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Protein disulfide-isomerase A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005788">
        <property type="entry name" value="PDI_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041868">
        <property type="entry name" value="PDIA3_PDI_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005792">
        <property type="entry name" value="Prot_disulphide_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01130">
        <property type="entry name" value="ER_PDI_fam"/>
        <property type="match status" value="1"/>
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    <dbReference type="NCBIfam" id="TIGR01126">
        <property type="entry name" value="pdi_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929">
        <property type="entry name" value="PROTEIN DISULFIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929:SF132">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10 11" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Thioredoxin" evidence="15">
        <location>
            <begin position="43"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="15">
        <location>
            <begin position="399"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="528"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="537"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="11">
        <location>
            <begin position="97"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="11">
        <location>
            <begin position="446"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605792-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005000467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="547" mass="60368" checksum="B7DDD4DB0B37E136" modified="2022-01-19" version="1">MGSCHTADPAAEAGLPACGPRLLFSRRRRRGGSAAPRGAAMSVSVSRPPPAALLLLLPFVALSAGASDVVELSDADFESGLAERPGLVLVEFFAPWCGHCKRLAPEYEAAATRLKGIVPLVKVDCTANSNTCNKYGVSGYPTLKIFRDGEESGTYDGPRTADGIVSHLKKQAGPASVALSSVADFEKFIGDKDASVVGFFRDASSDAYSEFMKAANNLRDNYRFAHTSEEQLVQKYEEDGEGVVLFRPSRLANKFEDSTVKYTEDKVTSAKIKKFIQENIFGICPHMTEDNKDLIQGKDLLVAYYDVDYEKNAKGSNYWRNRVMMIAKKFLDAGHKLSFAVASRKTFGHELSEFGLDNSVGEAPVVAIRTAKGDKYVMQEEFSRDGKALERFLHDYFGGNLKKYLKSEPVPENNDGPVKVVVAENFDEIVNAEDKDVLIEFYAPWCGHCKNLEPKYKELGEKLSKDPNIVIAKMDATANDVPSPYEVRGFPTIYFAPAGKKQSPKKYEGGREVSDFISYLKREATNTPVLQEEDKAKKSKKKAKEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SPQ6</accession>
    <name>A0A8C2SPQ6_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">mitogen-activated protein kinase kinase</fullName>
            <ecNumber evidence="8">2.7.12.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">MAP2K3</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.2" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2SPQ6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005002235.1">
        <property type="protein sequence ID" value="ENSCJPP00005001325.1"/>
        <property type="gene ID" value="ENSCJPG00005001368.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160875"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060048">
        <property type="term" value="P:cardiac muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071493">
        <property type="term" value="P:cellular response to UV-B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035924">
        <property type="term" value="P:cellular response to vascular endothelial growth factor stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035331">
        <property type="term" value="P:negative regulation of hippo signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904784">
        <property type="term" value="P:NLRP1 inflammasome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038066">
        <property type="term" value="P:p38MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043536">
        <property type="term" value="P:positive regulation of blood vessel endothelial cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070269">
        <property type="term" value="P:pyroptotic inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001817">
        <property type="term" value="P:regulation of cytokine production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031098">
        <property type="term" value="P:stress-activated protein kinase signaling cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd06617">
        <property type="entry name" value="PKc_MKK3_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000040">
        <property type="entry name" value="Dual specificity mitogen-activated protein kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000158">
        <property type="entry name" value="Dual specificity mitogen-activated protein kinase kinase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013:SF21">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="65"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005001325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="348" mass="39467" checksum="9B8389AF2EBA61DE" modified="2022-01-19" version="1">MSPCSLPDSKGSLEPHKPAKGKKKLRITCPPIKQPPVNTTPPRNLDSRTFITIGDKNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNTQEQKRLLMDLDISMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYKKVLEKKKTIPEDILGKMAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYNVKSDVWSLGITMIELAILRFPYESWGTPFQQLKQVVEEPSPQLPAERFSKEFVDFTAQCLRKNPAERMNYLELMEHPFFTLHDTKETDMASFVTEILGEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SQC8</accession>
    <name>A0A8C2SQC8_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Heterogeneous nuclear ribonucleoprotein A1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC107307582</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SQC8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005004029.1">
        <property type="protein sequence ID" value="ENSCJPP00005002230.1"/>
        <property type="gene ID" value="ENSCJPG00005002420.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183123"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12761">
        <property type="entry name" value="RRM1_hnRNPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12582">
        <property type="entry name" value="RRM2_hnRNPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000048">
        <property type="entry name" value="Heterogeneous nuclear ribonucleoprotein a1 isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000429">
        <property type="entry name" value="Heterogeneous nuclear ribonucleoprotein A1-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034516">
        <property type="entry name" value="hnRNPA1/3_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034845">
        <property type="entry name" value="hnRNPA1_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48026:SF2">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN A1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48026">
        <property type="entry name" value="HOMOLOGOUS TO DROSOPHILA SQD (SQUID) PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="79"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="170"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="251"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="322"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="252"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="262"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="322"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="340"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005002230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="376" mass="39444" checksum="F7A68C11C30C6ACC" modified="2022-01-19" version="1">MRSSAGEPAGERRPIGSSGGRDFSGGGGVRRRRSGRSAPFCVGASQREHRAQPPHTAPSRPLAAIMAKSESPKEPEQLRKLFIGGLSFETTDESLRSHFEQWGTLTDCVVMRDPNTKRSRGFGFVTYSSVEEVDAAMNARPHKVDGRVVEPKRAVSREDSQRPGAHLTVKKIFVGGIKEDTEEHHLRDYFGQYGKIEVIEIMTDRGSGKKRGFAFVTFDDHDSVDKIVIQKYHTINGHNCEVKKALSKQEMASASASQRGRSGSGNFGGGRGGGFGGNDNFSRGGNFGGRGGFGGSRGGGYGGGGDGYNGFGNDGYGGSGPGYSGGNRGYGGSSSYDGYNNGGGGFGGGSGGRRPARGPALAVRNGLSEAGTGETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SQT4</accession>
    <name>A0A8C2SQT4_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SQT4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005004430.1">
        <property type="protein sequence ID" value="ENSCJPP00005002422.1"/>
        <property type="gene ID" value="ENSCJPG00005002656.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01050000244936"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019814">
        <property type="term" value="C:immunoglobulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:002198">
        <property type="entry name" value="Immunoglobulin heavy variable 5-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050199">
        <property type="entry name" value="IgHV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23266">
        <property type="entry name" value="IMMUNOGLOBULIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="1" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-1280">Immunoglobulin</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034282356" description="Ig-like domain-containing protein" evidence="4">
        <location>
            <begin position="22"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="27"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005002422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="153" mass="16279" checksum="E885DBEFE902F8BD" modified="2022-01-19" version="1">SAWSWSWLCLMAAVTLDESGGGLYAPGGGLSLVCKGSGFTFSDYGMYWVRQAPGKGLEFVAGISFGDEYGPAVQGRATITRDNGQSTVRLQLNSLKDEDSAMYYCAKDAYGAGSGWGYVAYGIDVAAGYRYYNADGHGYGYGYTDRFAPAPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SQU3</accession>
    <name>A0A8C2SQU3_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SQU3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005004481.1">
        <property type="protein sequence ID" value="ENSCJPP00005002434.1"/>
        <property type="gene ID" value="ENSCJPG00005002682.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005002434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="168" mass="17783" checksum="1356A238F3F7DAC2" modified="2022-01-19" version="1">MGPTATLMGPPNTYGSTPHLMGPTHTYGAAPHLWGSPHTYGSHSPHLWVPPRTLMGAAPLLWGSRHTCGSHRKLMGPTPTYGSAPHTYGASPTLMGPRPHTYGFPPPYGSAPHTYGSTHTYGAAPHLWVPPPHLWGSAQHLWVPPHTYGSRRLGTPFSPAVSGGSVGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SR05</accession>
    <name>A0A8C2SR05_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">Platelet-activating factor acetylhydrolase</fullName>
            <ecNumber evidence="3 11">3.1.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">PLA2G7</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17777"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30909"/>
            <dbReference type="ChEBI" id="CHEBI:36707"/>
            <dbReference type="EC" id="3.1.1.47"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.47" evidence="3 11"/>
    <dbReference type="RefSeq" id="XP_032299471.1">
        <property type="nucleotide sequence ID" value="XM_032443580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SR05"/>
    <dbReference type="Ensembl" id="ENSCJPT00005004594.1">
        <property type="protein sequence ID" value="ENSCJPP00005002504.1"/>
        <property type="gene ID" value="ENSCJPG00005002760.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107312468"/>
    <dbReference type="KEGG" id="cjo:107312468"/>
    <dbReference type="CTD" id="7941"/>
    <dbReference type="GeneTree" id="ENSGT00390000005233"/>
    <dbReference type="OrthoDB" id="2363873at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034364">
        <property type="term" value="C:high-density lipoprotein particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034362">
        <property type="term" value="C:low-density lipoprotein particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003847">
        <property type="term" value="F:1-alkyl-2-acetylglycerophosphocholine esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047499">
        <property type="term" value="F:calcium-independent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034440">
        <property type="term" value="P:lipid oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034374">
        <property type="term" value="P:low-density lipoprotein particle remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034638">
        <property type="term" value="P:phosphatidylcholine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034441">
        <property type="term" value="P:plasma lipoprotein particle oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062234">
        <property type="term" value="P:platelet activating factor catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090026">
        <property type="term" value="P:positive regulation of monocyte chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000062">
        <property type="entry name" value="Platelet-activating factor acetylhydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016715">
        <property type="entry name" value="PAF_acetylhydro_eukaryote"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272">
        <property type="entry name" value="PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272:SF12">
        <property type="entry name" value="PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03403">
        <property type="entry name" value="PAF-AH_p_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018169">
        <property type="entry name" value="PAF_acetylhydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 11" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="8 11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="active site" description="Nucleophile" evidence="12">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="12">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="12">
        <location>
            <position position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR018169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR018169-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005002504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="422" mass="46967" checksum="22909830E98CCB2C" modified="2022-01-19" version="1">MASLWVRARKLFMKSRSSGLSAKAAPEMGSGGADRGYRIPAGKGPHNVGCTDLMTGNAAEGSFLRLYYPSCDDTEIEETPWIPDKEYYQGLCDFLNMYRAVGERLFQYYVGSVTCPAKSNAAFKPGEKYPLLVFSHGLGAFRTIYSAICIEMASQGFLVAAVEHRDESASATYFCKKKGDSEPEEEAASGVEKEWIYYRKLRAGEEERCLRHQQVLQRAQECIKALDLILKINSGEDVMNVLNSGFDWNHLKDSVDTSRIAVMGHSFGGATVIESLSKEIRFRCGIALDAWMLPVGDDTYQSSVQQPLLFINSEKFQWASNVLKMKELSSNDTNKKMITIKGSVHQSFPDFTFVSGEIIGKFFKLKGEIDPNEAIDICNHASLAFLQKHLSLQRDFDKWDSLVDGIGPNVISGTNIDLSPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SR52</accession>
    <name>A0A8C2SR52_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SR52"/>
    <dbReference type="Ensembl" id="ENSCJPT00005004597.1">
        <property type="protein sequence ID" value="ENSCJPP00005002507.1"/>
        <property type="gene ID" value="ENSCJPG00005002764.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158908"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005002507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="78" mass="8615" checksum="BB9A0577B54DD9C3" modified="2022-01-19" version="1">MAEEGKGGYSEHDDRVVGRGFSGRRKKGRGPFRGKMYSEMNRNSRNRGGTGPSSSRQRQDEDDGDVAMSDAHDAPRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SRA0</accession>
    <name>A0A8C2SRA0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">LIM domain only protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LMO3</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015723333.1">
        <property type="nucleotide sequence ID" value="XM_015867847.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SRA0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005004900.1">
        <property type="protein sequence ID" value="ENSCJPP00005002626.1"/>
        <property type="gene ID" value="ENSCJPG00005002941.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107316419"/>
    <dbReference type="KEGG" id="cjo:107316419"/>
    <dbReference type="CTD" id="55885"/>
    <dbReference type="GeneTree" id="ENSGT00940000153908"/>
    <dbReference type="OrthoDB" id="6352355at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140297">
        <property type="term" value="F:DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070373">
        <property type="term" value="P:negative regulation of ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045600">
        <property type="term" value="P:positive regulation of fat cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000324">
        <property type="term" value="P:positive regulation of nuclear receptor-mediated glucocorticoid signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035360">
        <property type="term" value="P:positive regulation of peroxisome proliferator activated receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09388">
        <property type="entry name" value="LIM1_LMO1_LMO3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09389">
        <property type="entry name" value="LIM2_LMO1_LMO3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000015">
        <property type="entry name" value="LIM domain only 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000016">
        <property type="entry name" value="LIM domain only 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050945">
        <property type="entry name" value="LMO_RBTN_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45787">
        <property type="entry name" value="LD11652P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45787:SF7">
        <property type="entry name" value="LIM DOMAIN ONLY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034878612" description="LIM domain only protein 3" evidence="7">
        <location>
            <begin position="31"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="8">
        <location>
            <begin position="55"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="8">
        <location>
            <begin position="119"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005002626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="189" mass="21908" checksum="9AE5724233A34B11" modified="2022-01-19" version="1">MRWTSDQWKFLLSSLFNIVFSLLWTRQIMSSCLCRCLYNELGIQMLSVQPDTKPKGCAGCNRKIKDRYLLKALDKYWHEDCLKCACCDCRLGEVGSTLYTKANLILCRRDYLRLFGVTGNCAACSKLIPAFEMVMRAKDNVYHLDCFACQLCNQRFCVGDKFFLKNNMILCQTDYEEGLMKEGYAPQVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SRB9</accession>
    <name>A0A8C2SRB9_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">V-set and immunoglobulin domain containing 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">VSIG4</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_032300448.1">
        <property type="nucleotide sequence ID" value="XM_032444557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SRB9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005004944.1">
        <property type="protein sequence ID" value="ENSCJPP00005002650.1"/>
        <property type="gene ID" value="ENSCJPG00005002969.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107312529"/>
    <dbReference type="CTD" id="11326"/>
    <dbReference type="GeneTree" id="ENSGT00390000001432"/>
    <dbReference type="OrthoDB" id="9448246at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001851">
        <property type="term" value="F:complement component C3b binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045957">
        <property type="term" value="P:negative regulation of complement activation, alternative pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032703">
        <property type="term" value="P:negative regulation of interleukin-2 production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043031">
        <property type="term" value="P:negative regulation of macrophage activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042130">
        <property type="term" value="P:negative regulation of T cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039939">
        <property type="entry name" value="VSIG4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15466">
        <property type="entry name" value="V-SET AND IMMUNOGLOBULIN DOMAIN CONTAINING 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15466:SF2">
        <property type="entry name" value="V-SET AND IMMUNOGLOBULIN DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034124316" evidence="2">
        <location>
            <begin position="20"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="35"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="143"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005002650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="359" mass="39275" checksum="A5D99E5FDB4019F2" modified="2022-01-19" version="1">MGAVVLLAVVVMAFVGCRALLDLSGATQVKGVWMGSTTLPCTYTPSQGFTQQTLTWSMERDLSTSTIFRRDSSGDHIPLSQFRNRVSVPKSSPGDASLHITDLEIPDSGHYTCQIIWRSENYSLITKEVTTTFKVAKEVVTKPIIVAGELGLVVPAGAKARLTCVAQGSPPISYHWFRVAPGRNGQLLGSEAELVWNSLQPSDAGMYYCEVQNRVSTGVVRRSDTVELTVRDLSVATEAHRPATDLPEAAVTSENAVGYPETDETTQSSRRSHLYLFILIAVLGGAVVFFVIFAIACARKSKNEPIYEVSFHCEDVIRLDTDVEVPVKCRKEKINSETEESYENVTMTCNSYASMTGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SU97</accession>
    <name>A0A8C2SU97_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SU97"/>
    <dbReference type="Ensembl" id="ENSCJPT00005005050.1">
        <property type="protein sequence ID" value="ENSCJPP00005002724.1"/>
        <property type="gene ID" value="ENSCJPG00005003031.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158241"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008112">
        <property type="entry name" value="Relaxin_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372:SF70">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372">
        <property type="entry name" value="GLYCOPROTEIN HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01739">
        <property type="entry name" value="RELAXINR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="42"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005002724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="222" mass="24098" checksum="5345636891174D5A" modified="2022-01-19" version="1">MGSSIPAGCKPNTDGISSFEHLLANIILRVFVWVIACITCLGNICVICMRSCVVTESSAHTMAIKSLCCADGLMGIYLFVIGAFDLKYSGEYNRHAQGWMASMPCQLVGSLAMLSSEVSVLLLTYMTLEKYFSIVFPFSYRRAGRKQTATVLAAIWLLGLSLSIVPLCCRESFGNYYGRNGVCFPLQSELGERPSARDFSTTIYLGEALGRDGDGVWSTGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SUM6</accession>
    <name>A0A8C2SUM6_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Oxysterol-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">OSBPL2</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the OSBP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015736976.1">
        <property type="nucleotide sequence ID" value="XM_015881490.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015736977.1">
        <property type="nucleotide sequence ID" value="XM_015881491.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SUM6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005005011.1">
        <property type="protein sequence ID" value="ENSCJPP00005002693.1"/>
        <property type="gene ID" value="ENSCJPG00005003003.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005005017.1">
        <property type="protein sequence ID" value="ENSCJPP00005002697.1"/>
        <property type="gene ID" value="ENSCJPG00005003003.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005005022.1">
        <property type="protein sequence ID" value="ENSCJPP00005002702.1"/>
        <property type="gene ID" value="ENSCJPG00005003003.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107322935"/>
    <dbReference type="KEGG" id="cjo:107322935"/>
    <dbReference type="CTD" id="9885"/>
    <dbReference type="GeneTree" id="ENSGT00940000158762"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098831">
        <property type="term" value="C:presynaptic active zone cytoplasmic component"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015485">
        <property type="term" value="F:cholesterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120020">
        <property type="term" value="F:cholesterol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008526">
        <property type="term" value="F:phosphatidylinositol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032367">
        <property type="term" value="P:intracellular cholesterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007009">
        <property type="term" value="P:plasma membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051289">
        <property type="term" value="P:protein homotetramerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099509">
        <property type="term" value="P:regulation of presynaptic cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010807">
        <property type="term" value="P:regulation of synaptic vesicle priming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000005">
        <property type="entry name" value="Oxysterol-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3490:FF:000003">
        <property type="entry name" value="Oxysterol-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF153">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="410"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005002697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="481" mass="55526" checksum="C0D329D0B456EC9F" modified="2022-01-19" version="1">MNSEEEFYDAVTGFDSDNSSGEFSEANHKVKEMLDLDPHQSSRTRKHNGETEIQENGIKRHRTSLPAPMFSRSDFSVWSILKKCIGLELSKITMPIVFNEPLSFLQRITEYMEHIYLINKACSHSDPLERMQAVAAFAVSAVASQWERTGKPFNPLLGETYELTREDLGFRFISEQVSHHPPISAFYSEGLNNDFIFHGSIYPKLKFWGKSIEAEPRGTITLELLKHNEAYTWTNPTCCVHNVIIGKLWLEQYGTVEIVNHSTGDKCVLNFKPCGLFGKELHRVEGYIQDKNRKKLCVIYGKWTECLWCTDPTTYETYKKNEKRGGEQKKLKSSEDVIKSENDEADDMPEVQDTVQFIPGSKLLWRINCRPPNSSQMYNFTSFAVSLNELEKGMEAILAPTDCRLRPDIRNMENGNMDVASKEKERLEEKQRAARKERAKDEVEWQTRWFHQGTNPYTGTSDWLYSGGYFDRNFSDCPDIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SVT2</accession>
    <name>A0A8C2SVT2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bardet-Biedl syndrome 2 protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">BBS2</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell projection</location>
            <location evidence="6">Cilium membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
            <location evidence="6">Cytoskeleton</location>
            <location evidence="6">Microtubule organizing center</location>
            <location evidence="6">Centrosome</location>
            <location evidence="6">Centriolar satellite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SVT2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005005132.1">
        <property type="protein sequence ID" value="ENSCJPP00005002776.1"/>
        <property type="gene ID" value="ENSCJPG00005002316.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000017113"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034464">
        <property type="term" value="C:BBSome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060170">
        <property type="term" value="C:ciliary membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005902">
        <property type="term" value="C:microvillus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032420">
        <property type="term" value="C:stereocilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061629">
        <property type="term" value="F:RNA polymerase II-specific DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030534">
        <property type="term" value="P:adult behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014824">
        <property type="term" value="P:artery smooth muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048854">
        <property type="term" value="P:brain morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051216">
        <property type="term" value="P:cartilage development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021987">
        <property type="term" value="P:cerebral cortex development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045444">
        <property type="term" value="P:fat cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038108">
        <property type="term" value="P:negative regulation of appetite by leptin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040015">
        <property type="term" value="P:negative regulation of multicellular organism growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045494">
        <property type="term" value="P:photoreceptor cell maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040018">
        <property type="term" value="P:positive regulation of multicellular organism growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060296">
        <property type="term" value="P:regulation of cilium beat frequency involved in ciliary motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007288">
        <property type="term" value="P:sperm axoneme assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021756">
        <property type="term" value="P:striatum development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042311">
        <property type="term" value="P:vasodilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000967">
        <property type="entry name" value="Bardet-Biedl syndrome 2 protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016616">
        <property type="entry name" value="Bardet-Biedl_syndrome_2_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055381">
        <property type="entry name" value="BBS2_CtH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029333">
        <property type="entry name" value="BBS2_GAE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055380">
        <property type="entry name" value="BBS2_hp_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029429">
        <property type="entry name" value="BBS2_Mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029430">
        <property type="entry name" value="BBS2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055379">
        <property type="entry name" value="BBS2_pf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32465">
        <property type="entry name" value="BARDET-BIEDL SYNDROME 2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32465:SF0">
        <property type="entry name" value="BARDET-BIEDL SYNDROME 2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23351">
        <property type="entry name" value="BBS2_CtH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23353">
        <property type="entry name" value="BBS2_hp"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF14783">
        <property type="entry name" value="BBS2_Mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14781">
        <property type="entry name" value="BBS2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23350">
        <property type="entry name" value="BBS2_pf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF013684">
        <property type="entry name" value="BBS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3 6" id="KW-0969">Cilium</keyword>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ciliary BBSome complex subunit 2 N-terminal" evidence="7">
        <location>
            <begin position="20"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Ciliary BBSome complex subunit 2 middle region" evidence="9">
        <location>
            <begin position="165"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="BBS2 GAE" evidence="8">
        <location>
            <begin position="391"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="BBS2 platform" evidence="10">
        <location>
            <begin position="480"/>
            <end position="571"/>
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            <begin position="583"/>
            <end position="680"/>
        </location>
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        <location>
            <begin position="685"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
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    </evidence>
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    </evidence>
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    </evidence>
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            <dbReference type="Pfam" id="PF23353"/>
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        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005002776.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="717" mass="78550" checksum="EED3C252DAB53D6C" modified="2022-01-19" version="1">MLVPVFTLKLSHKLQPRTVALGRFDGAHPCLAAATQAGKVLVHSPHAPGPRTGGSRAAPSIQDTHVSLLSINQAVTCVAAGPLRAALRRDCLLVGTRTHLLAYDVHLNSDLFYREVSDGANAIVLGALGDVPSPLAIIGGNCALQGFDYEGNEVFWTVTGDNVRSLALCDFDGDGKNEVVLGVQNLACSHCCVLSLSPYKTVTALSPMYGSRFGYALSNGTVGVYDRTSRYWRIKSKNHAMSIHAFDLNSDGVCELITGWSNGKVDARSDRTGEVIFKDNFASSIAGVVEGDYRMDGSMQLICCSVDGEVRGYLPGGEEMKGNLMDTCAEQDMIRELSQKKQNLLLELRNYEENTKAELSPQLKDADGQRGVIPANTQLQTSLSVNLGSDSQSAHVELCISTTNDTIIRAVLIFAEGIFEGESHVVHPGLQNLSGCVRVPLAPPKDVSVDLHIKAFVGYRNSTQFYVFELTRQLPRFSMYALSSLDSATEPLSFVSCATNERPQRIVVWLNQSFLLPEDAEFQSAPFQVCFTSLRNAGQLLIKIKHGGEISICTDDIDLAGDIIQSMASFLAIEDLQVEADFPAYFEELRKVLVKVDEHHSVNQRLTADMADRSNLIRVMLVQAEDARLLGDMKNVKTRYVELYDLNRDLINQYKIRCNNHTELLSNLKAVNQAIQRAGQLRVGKPKAQVIAACRDAIRSNNFNTLFRIMRSGVASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SVT9</accession>
    <name>A0A8C2SVT9_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Thyroid hormone-inducible hepatic protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC107308548</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SPOT14 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015708001.1">
        <property type="nucleotide sequence ID" value="XM_015852515.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SVT9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005007609.1">
        <property type="protein sequence ID" value="ENSCJPP00005004568.1"/>
        <property type="gene ID" value="ENSCJPG00005004500.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107308548"/>
    <dbReference type="KEGG" id="cjo:107308548"/>
    <dbReference type="GeneTree" id="ENSGT00500000044890"/>
    <dbReference type="OrthoDB" id="9450804at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046890">
        <property type="term" value="P:regulation of lipid biosynthetic process"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="Lipogen_MT_Stabilize_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009786">
        <property type="entry name" value="Spot_14"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="THYROID HORMONE-INDUCIBLE HEPATIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07084">
        <property type="entry name" value="Spot_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
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    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005004568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="130" mass="14268" checksum="1468156A6AAE7525" modified="2022-01-19" version="1">MEQYFSATQKMEQEVMFPSLLRGVFPQDGADPASDGSADLYERYQLLKAIKPVVQRGLASVTERSSASDDDDDADAAADGADGSLEQRLCHHLAGLQQILSHLTRDTAALTRRYSQILERISPGDAQPSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SWB0</accession>
    <name>A0A8C2SWB0_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Complement C1q like 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">C1QL4</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SWB0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005006008.1">
        <property type="protein sequence ID" value="ENSCJPP00005003381.1"/>
        <property type="gene ID" value="ENSCJPG00005003573.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155969"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome LGE22C19W28_E50C23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.40:FF:000001">
        <property type="entry name" value="Complement C1q B chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050822">
        <property type="entry name" value="Cerebellin_Synaptic_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22923">
        <property type="entry name" value="CEREBELLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22923:SF67">
        <property type="entry name" value="COMPLEMENT C1Q-LIKE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00007">
        <property type="entry name" value="COMPLEMNTC1Q"/>
    </dbReference>
    <dbReference type="SMART" id="SM00110">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50871">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0176">Collagen</keyword>
    <keyword evidence="5" id="KW-0379">Hydroxylation</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="C1q" evidence="8">
        <location>
            <begin position="446"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="390"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="74"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="89"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="413"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005003381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="579" mass="58225" checksum="CF7AA838F848C66F" modified="2022-01-19" version="1">RGRRSRGTWREVPSRLHPGSGYITSTSTGSGPACTSGSASGSGPGCSGSSAPGSALGSSPDSAPGSGPSSAPGTGTGTGTGTGTGTGTGSALVPSASSSPGSARSSAPGSGPDINSSPAAPCPAPSLPAPVLSPSVCPYSFSHPCPIPIPTHNPHPGPFDPSPIPVPIPVLAVSSSASPTAVLIPIPVPLPIPGPISTPPGVPSSDLVPIPAASSIPTALPIPVPTTTSIPIPVPIPSAVTILTTISNPILTSVTIPIPDLIPAAVPILIPIPTSLPSTSSIPTAVLIPPHPRSHPVPCRALRLSGRPPAVHPPGSTIAPKGDEDLLALAASRLSRRKRVAGAAVGVAMVLVLLVAIPLLVHSSKAAAHYEMLGSCRMVCDPYPELPPASPPPFLPGAKGEPGRKGRTGVRGPPGPPGPRGPPGEPGRPGPPGPPGPGPGGYIPSFYSPKIAFYAGLKKPHEGYEVLKFDDVVTNLGNYYEPSSGKFTCPLPGIYFFTYHVLMRGGDGTSMWADLMKNGQVRASAIAQDADQNYDYASNSVILHLDAGDEVCVKLDGGKVHGGNTNKYSTFSGFIIYPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SWL2</accession>
    <name>A0A8C2SWL2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Breast cancer anti-estrogen resistance protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">CRK-associated substrate</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">p130cas</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">BCAR1</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Focal adhesion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Axon</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CAS family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SWL2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005007810.1">
        <property type="protein sequence ID" value="ENSCJPP00005004718.1"/>
        <property type="gene ID" value="ENSCJPG00005004583.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183008"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001726">
        <property type="term" value="C:ruffle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050853">
        <property type="term" value="P:B cell receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060326">
        <property type="term" value="P:cell chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035729">
        <property type="term" value="P:cellular response to hepatocyte growth factor stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0086100">
        <property type="term" value="P:endothelin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048012">
        <property type="term" value="P:hepatocyte growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048008">
        <property type="term" value="P:platelet-derived growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010595">
        <property type="term" value="P:positive regulation of endothelial cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048010">
        <property type="term" value="P:vascular endothelial growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd11569">
        <property type="entry name" value="FAT-like_BCAR1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11552">
        <property type="entry name" value="Serine_rich_BCAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.830:FF:000001">
        <property type="entry name" value="BCAR1 scaffold protein, Cas family member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.230:FF:000001">
        <property type="entry name" value="Breast cancer anti-estrogen resistance 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000009">
        <property type="entry name" value="Breast cancer anti-estrogen resistance 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.230">
        <property type="entry name" value="Alpha-catenin/vinculin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.830">
        <property type="entry name" value="Serine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046976">
        <property type="entry name" value="BCAR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021901">
        <property type="entry name" value="CAS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037362">
        <property type="entry name" value="CAS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014928">
        <property type="entry name" value="Serine_rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038319">
        <property type="entry name" value="Serine_rich_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10654:SF15">
        <property type="entry name" value="BREAST CANCER ANTI-ESTROGEN RESISTANCE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10654">
        <property type="entry name" value="CAS SCAFFOLDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12026">
        <property type="entry name" value="CAS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08824">
        <property type="entry name" value="Serine_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01887">
        <property type="entry name" value="SPECTRNALPHA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="9" id="KW-0965">Cell junction</keyword>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="11" id="KW-0729">SH3-binding</keyword>
    <feature type="domain" description="SH3" evidence="18">
        <location>
            <begin position="223"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="291"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="575"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="649"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="846"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="116"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="292"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="658"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00072413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00079691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00081467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005004718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1107" mass="119595" checksum="8F536242A7609A97" modified="2022-01-19" version="1">MGPGRERRSERIRDQPGTERRERGPSGGEGPDGASGTERGRHRPDPTQPPPATGSALPARSGHGSSRGGRGALPLRGCAALPAPRDPPERGGRRKDSGGGRGHRAGQRGITGGTGRQRDGHTDTDTHTRVPVPARRPGGNSRCGLSHLHGTSSPAGRGGKGRGGPRHREARGVRPRPGAGSGTGGLNRDEEEQRRGRVGCRAPLVPPSPSAMSPDPARCGALLQNVLAKALYDNVAESPDELSFRKGDIMTVLERNTQGLDGWWLCSLHGRQGIVPGNRLKILVGMYDKKQQQQQQAAGPGQGQAPPAPQPTLPYHHQGGYTPLSPASQYTAMHPSYAPQGDNVYLMPVPGKGQQGLYSGSAPAGQFPPAPAKQPPSYPKQTPPHGFPSAGQDIYQVPPSLSQDIYQVPPSAQAQDIYQVPPSLDARSWEGPKPSGKVLLPTRVGQAYVYDSPKAEKDEYDFPRHLLSSGSQEIYDVPPARGALPSQQVYDTPPMAVKGPNGQDPGQEIYDVPPSVEKNLHQTVYDVPPSVSKDVPDGPVREETYDVPPAFSKQKAFEPPRHPPVLSQQDSYLPEDVYDVPPAAGKAAPEPSLSHEIYDVPPSLKKLGGSAFPLQEVYDVPRDLHAPSKGSMDMEGEYIYDVPPQVDREAKAADTKRLSASSTGSTRSNISTSSLDTVPVKEPAKGAGREFSLDLDAAMEMLAKLQLGVSGAVSSLMSFISTNWRSPEHMEANAAGIRLAAEGVQTALRELLEFARGAVGNAAQASDRSLYAKLSKQLQKMEEVYQALGRHSQALDACHWAPSALVAGKPGTDDLELFVMYSRGVPDDTKQLASFLHGNASLLFKRTKPAPEGNGHGPTHPSDKASSIQSRPLPSPPKLLAQESPEGPYENHESGWMEDYDYVHLQGKEEFEKTQKELLEKGNIIRQSKDQLEHQQLKQFERLEQEVTRPIDNDLSNWSPPQHYGPVRGGGALCAADHQLLLFYLEQCEANLTTLTNAIDAFFTAVSTNQPPKIFVAHSKFIILSAHKLVFIGDTLSRQAKAQDVRHKVTHYSNLLCEMLKEIVVSTKAAALHYPSPAASKDMVERVKDLANSTQQFRRVLGQLAAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SWV3</accession>
    <name>A0A8C2SWV3_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phospholipid phosphatase 7 (inactive)</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SWV3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005006335.1">
        <property type="protein sequence ID" value="ENSCJPP00005003609.1"/>
        <property type="gene ID" value="ENSCJPG00005003750.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157147"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005003609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="241" mass="25731" checksum="0B237EDD85BAC50E" modified="2022-01-19" version="1">MPASQTRSRARDRNNVLNRAEFLSLNQPPKGTQESRSSGRKQSGQTAAAGTQNSNPKERRQSQQLPEEDCMQLNPSFKGIAFNSLLAIDICMSKRLGVCANRASSWGGARSMINLLGITGHGIPWIAGTLICLVKSSTLAGQEVLMNLLLGEWQSSIPTGLPSPCHKGWWHWGSSSGCSHCDVLGDLLLCLSAALAAPCWSWVLGVMDVVSKGAGILVAGHSHRAALHKAWVGPAGPRKCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SX26</accession>
    <name>A0A8C2SX26_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytochrome b5 reductase 4</fullName>
            <ecNumber evidence="4">1.6.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Flavohemoprotein b5/b5R</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">cb5/cb5R</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">CYB5R4</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46680"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2SX26"/>
    <dbReference type="Ensembl" id="ENSCJPT00005007242.1">
        <property type="protein sequence ID" value="ENSCJPP00005004305.1"/>
        <property type="gene ID" value="ENSCJPG00005004299.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155536"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090524">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NADH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016174">
        <property type="term" value="F:NAD(P)H oxidase H2O2-forming activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042593">
        <property type="term" value="P:glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030073">
        <property type="term" value="P:insulin secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006801">
        <property type="term" value="P:superoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06490">
        <property type="entry name" value="p23_NCB5OR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000063">
        <property type="entry name" value="Cytochrome b5 reductase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000001">
        <property type="entry name" value="Cytochrome b5 reductase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000021">
        <property type="entry name" value="Cytochrome b5 reductase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.790:FF:000019">
        <property type="entry name" value="cytochrome b5 reductase 4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051872">
        <property type="entry name" value="Cytochrome_b5/Flavoprotein_Rdt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037908">
        <property type="entry name" value="p23_NCB5OR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46237:SF1">
        <property type="entry name" value="CYTOCHROME B5 REDUCTASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46237">
        <property type="entry name" value="CYTOCHROME B5 REDUCTASE 4 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="18">
        <location>
            <begin position="54"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="CS" evidence="19">
        <location>
            <begin position="167"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="20">
        <location>
            <begin position="275"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005004305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="523" mass="59501" checksum="5310BAB5E44758C8" modified="2022-01-19" version="1">MLNVPPQAFPASGSQQRVAVGGRTKVPLKPGRSLMDWIRLTKSGKDLTGLKGRLIEVTEDELAKHNKKEDCWICIAGLVYNVTPYMEYHPGGEDELMKAAGTDGTDLFDQVHRWVNYESMLKECLVGRMAFKPIAAPKDISSTLPEEKKQLNGMLSERKVLGASARDTTPSYDWFQTDDMITVVIYTKQKGMNAELVIVDCQDKRLRGEIILDDYSYLVEVDLDYEVEDDFAVNIAEKIGKVEIILKKKDHSQWKVLGLPLEGHNTLIRRKERGLFYRKCKLVSKTEVTHDTRLFCFMLPKSTHLQVPIGQHVYLKQIIAGTEVVKPYTPLLPFLPLDFKEPFCQDGAHIYLMIKIYSCGLFTQALDHLQIGDDISVSNPEGNFEKSQVEALEDLFLLAAGTGFTPMVKLLNFALTKVDCLRTVKLIFFNKKEDDILWRNQLEQLALRDERFEVQFILSEPKEDWMDKRGKISSALLSECMKRSKKDSKVLICICGPAPFTEQGLQYLKDLGYSQEEIHAFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SX35</accession>
    <name>A0A8C2SX35_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Reticulophagy regulator family member 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">RETREG3</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RETREG family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SX35"/>
    <dbReference type="Ensembl" id="ENSCJPT00005008381.1">
        <property type="protein sequence ID" value="ENSCJPP00005005112.1"/>
        <property type="gene ID" value="ENSCJPG00005004934.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000167154"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057282">
        <property type="entry name" value="RETREG1-3-like_RHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043384">
        <property type="entry name" value="RETREG1/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28659">
        <property type="entry name" value="RETICULON-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28659:SF1">
        <property type="entry name" value="RETICULOPHAGY REGULATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24456">
        <property type="entry name" value="RHD_RETREG1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="RETREG1-3/ARL6IP-like N-terminal reticulon-homology" evidence="11">
        <location>
            <begin position="160"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="381"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="11"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="381"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="399"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF24456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005005112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="542" mass="58670" checksum="35EBB52D2167F6DC" modified="2022-01-19" version="1">MPARSHGGGAARRAAAAGAGAERGAAGPPGAVRAAAERRAGRAAVGAAGPQRAVLGGGSRAVLVSAGTWLRGRRWLRGCGGCGACAGCAGRAAPPRSRPAPGPPARRFVPGRRCAARGGAGSSGRYGLRAGRSAASRVGECDLPARSFERRSCWSRICSFLCHRFFALTSLRLVCLVAFTLIVVVCLDQWKSKIWPEIGVARPDELDNESWGYVHPRLLGVPELCHHLAEGWVSWTNFLSNLFVFKRESPGKFCLLVCGVFTFLAVLGRYIPGLLLSYLLLLFVLLWPLAVYHRLGHRMYMKLEPALQRLDFSVRGYMISKQREKQLRRRSINQEGTDDGSDSEEELAAFCPKLDDSVVAKELTISDSEHSDAEVSYTESGMFNLSRGQTPLTEGSEDLDGHSDPEESFARDLPDFPSINPEATGLDDEDDTSIGIPSLAYRPQVTEDVHLPYYQEEAGVLPSVQNLTNNIAGFVTRGMIQLALSGATQQPGSSRSDNPHRDAKTYLRTASLDLDTDAEGDDFELLDQSELNQLDPAGSRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SZI0</accession>
    <name>A0A8C2SZI0_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Solute carrier family 25 member 36</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">SLC25A36</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015726695.1">
        <property type="nucleotide sequence ID" value="XM_015871209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SZI0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005009725.1">
        <property type="protein sequence ID" value="ENSCJPP00005006146.1"/>
        <property type="gene ID" value="ENSCJPG00005005758.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107317952"/>
    <dbReference type="KEGG" id="cjo:107317952"/>
    <dbReference type="CTD" id="55186"/>
    <dbReference type="GeneTree" id="ENSGT00940000154369"/>
    <dbReference type="OrthoDB" id="269120at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015218">
        <property type="term" value="F:pyrimidine nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990519">
        <property type="term" value="P:pyrimidine nucleotide import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051881">
        <property type="term" value="P:regulation of mitochondrial membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000074">
        <property type="entry name" value="Solute carrier family 25 member 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000124">
        <property type="entry name" value="Solute carrier family 25 member 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049562">
        <property type="entry name" value="SLC25A33/36-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829:SF2">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 MEMBER 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="4"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="118"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="226"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="313" mass="34596" checksum="2811F66DADBD5E08" modified="2022-01-19" version="1">MSQRDTLVHLFAGGCGGTVGAILTCPLEVVKTRLQSSSVTLYISEVHLNTVNGASVNRVTRVSPGPLHCLKMILQKEGPRSLFRGLGPNLVGVAPSRAIYFAAYSNCKEKLNNIFNPDSTQVHMISAGVAGFTAITMTNPIWLVKTRLQLDARNRGEKRMSAFECVRKVYRSDGIKGFYRGMSASYAGISETVIHFVIYESIKRKLLEHKIASAMDNEDESAKEASDFVGMMMAAATSKTCATSIAYPHEVVRTRLREEGTKYRSFFQTLSLLVREEGYGSLYRGLTTHLVRQIPNTAIMMSTYEVVVYLLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T093</accession>
    <name>A0A8C2T093_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein inturned</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Inturned planar cell polarity effector homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">INTU</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the inturned family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015716738.1">
        <property type="nucleotide sequence ID" value="XM_015861252.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T093"/>
    <dbReference type="Ensembl" id="ENSCJPT00005010184.1">
        <property type="protein sequence ID" value="ENSCJPP00005006458.1"/>
        <property type="gene ID" value="ENSCJPG00005006043.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107313206"/>
    <dbReference type="KEGG" id="cjo:107313206"/>
    <dbReference type="CTD" id="27152"/>
    <dbReference type="GeneTree" id="ENSGT00390000001301"/>
    <dbReference type="OrthoDB" id="10038586at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035869">
        <property type="term" value="C:ciliary transition zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="CCZ1/INTU_longin_2"/>
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        <property type="entry name" value="INTU"/>
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        <property type="entry name" value="PROTEIN INTURNED"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PROTEIN INTURNED"/>
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    </dbReference>
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        <property type="entry name" value="Intu_longin_1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PDZ domain-like"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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        <location>
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        </location>
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            <begin position="26"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
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            <end position="159"/>
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        <location>
            <begin position="702"/>
            <end position="736"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00010034"/>
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            <dbReference type="ARBA" id="ARBA00015639"/>
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            <dbReference type="ARBA" id="ARBA00022473"/>
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            <dbReference type="ARBA" id="ARBA00032633"/>
        </source>
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        </source>
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    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="945" mass="105182" checksum="84468B1D7A0F6316" modified="2022-01-19" version="1">MAAEGDGLSGAAGVEALRGVEALRDGSAGCADSGSESESGSAGSSAGSSLSHSSDDLEPEWLDGVQKNGELFYLEMSESEEETLLQNACPQIPPVNHVRFSENEAEVIQEGSRKERKYELKKLTKMLKKKNLLPKHSSKKGSGSCNVHSSGPTSILKQHSTQKMGEIQQKYKDICVYVNPRKLLDSAGEDEQHRLLEALVGIVHQSSWSSRRAEKRGKKDKVTRGIGEEKLVVHGLVPGSSAMKTGQILIGDALVAVNDVDVNSENIERVLSCIPGPMQVKLTFETSVFEPEGASQQRCKREQSSMNNLVRLLWGEDSMGLQQAVQSVPHIVMFLSLKLDSETSKDEQEILYQYPISEASQKLKNVRGIFLTLSDIMESVTGAQILSSSLFLCEKLVQVVYWKECDKLLVIGLPEENVSLTQLRNMIEDVVRTLKFMYSSLDSAFCQVEHVSRLDHFFNLFFQRALQPARLNSHVSPSAQHYATCSALFLDSLPGLRWLTLPQEIKMEIDTALSDLEAADFAEMSEDYYNMRRLYMIMGSCLFYKGYLIGNHLPKEDLIDIGLYSQHYCLLPLAAEQKIGQLVIWREVFPQHHIQPCEVSDFTGYTEPEARYFLLIVGLRHFMLCVLLEAGGCASKAIGNPGPDCIYVDQVKATILQLEGIDASIEERLDSPSIPPLSCADWFLPTTRDKLESLTTSPILSKIQNASRTETTPASKRTLFGDSSLTTRKPSPTRNSGGPDHHGNEGPAEDESNNLQSLADQVARKKHTLPNPPHLGNLKKNLSEKDLELFNTIKLTSGPENTLFHYLSLETMHGIFITPTHKEVARLGGSIHPQLIENFHRCCLSIRSVFQQCMMKDKKKKAGSKISEFNSTDEDLGPVREHGVLFECSPKNWNDQKKPPPTMSYWVVGRLFLHPKPQEFYVCFHDSVAEVAVELAFKLSFGLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T107</accession>
    <name>A0A8C2T107_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycoprotein Ib platelet subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">GP1BA</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015742086.1">
        <property type="nucleotide sequence ID" value="XM_015886600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T107"/>
    <dbReference type="Ensembl" id="ENSCJPT00005010294.1">
        <property type="protein sequence ID" value="ENSCJPP00005006536.1"/>
        <property type="gene ID" value="ENSCJPG00005006105.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107325583"/>
    <dbReference type="KEGG" id="cjo:107325583"/>
    <dbReference type="CTD" id="2811"/>
    <dbReference type="GeneTree" id="ENSGT00940000163073"/>
    <dbReference type="OrthoDB" id="8400687at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007616">
        <property type="term" value="P:long-term memory"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366">
        <property type="entry name" value="IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366:SF158">
        <property type="entry name" value="PLATELET GLYCOPROTEIN IB ALPHA CHAIN-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034159275" evidence="6">
        <location>
            <begin position="24"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="546"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="LRRCT" evidence="7">
        <location>
            <begin position="233"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="293"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="300"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="328"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="358"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="401"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="419"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="451"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="462"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="704" mass="75356" checksum="9D7EC991D5C5641D" modified="2022-01-19" version="1">MAARFPALLPLLLAALQPTFVPTEPPPPPCPWEMNKVKDIVEVNCSGRDLGAVPAGLPEDTGILLLNANRLPSVSTAAFQPLPALQDLDLSDNGLQALHADVPLPSLQELLLSRNALQALPALRFVPALTRLALAHNRLRALPPAAFRAVPGLRDLDLRGNALRTLPEDAFAELRALKDLDLSDNGLEELPAGLLRDLQQLETLWLSGNRLRALPSGFFPEGHLFAYVFLADNPWHCDCGLVYLRSWIHGNQVSVYEAERSLGKVKLEVAPEKVLCLSPPEHRLKPVIRFKPNCGHVGDAEEEDYDDYDEEPAPVTSLVNSSPPTYPPSSKAPTTAPRTPTQPPLTSIIPPLSTFADSSLAPTSSLTTPASTTASNSPPPASAGSTIPSTTQPPSTAPAHTAPPSPPHSPVSLPPAPSTSSHTQSPLPSHTASSPLTTSIAAFPAGPSALPSPTNTEGTSVATSSPAALTSPTPLLPNTTFSIHTPTLSAPLDTTRVPLPSPPLPPPLLCPCSAPAQAPSVLHSQSGVKVLHWEHWVLSRCCLLRWLLYLACLALLLLSVLPLSCCLAWLCLTGQHNPLQPQEMQHPLLRWENSAESHTTHLSIFRSPHQRSTFCTTKEVELRPEATSCTYCTIKDLGVQRSRPAKSFCTTKELWIRHSPLNASPNPFPVELTATKLSSRRSPSAHSLGRGVSAVGVKYAANTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T1E4</accession>
    <name>A0A8C2T1E4_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">diphosphoinositol-polyphosphate diphosphatase</fullName>
            <ecNumber evidence="5">3.6.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">NUDT4</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>diphospho-myo-inositol polyphosphate + H2O = myo-inositol polyphosphate + phosphate.</text>
            <dbReference type="EC" id="3.6.1.52"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Nudix hydrolase family. DIPP subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.52" evidence="5"/>
    <dbReference type="RefSeq" id="XP_015713641.1">
        <property type="nucleotide sequence ID" value="XM_015858155.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T1E4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005008380.1">
        <property type="protein sequence ID" value="ENSCJPP00005005111.1"/>
        <property type="gene ID" value="ENSCJPG00005004946.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107311562"/>
    <dbReference type="CTD" id="11163"/>
    <dbReference type="GeneTree" id="ENSGT00940000155210"/>
    <dbReference type="OrthoDB" id="2011998at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034431">
        <property type="term" value="F:bis(5'-adenosyl)-hexaphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034432">
        <property type="term" value="F:bis(5'-adenosyl)-pentaphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008486">
        <property type="term" value="F:diphosphoinositol-polyphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000298">
        <property type="term" value="F:endopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901911">
        <property type="term" value="P:adenosine 5'-(hexahydrogen pentaphosphate) catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901909">
        <property type="term" value="P:diadenosine hexaphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901907">
        <property type="term" value="P:diadenosine pentaphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071543">
        <property type="term" value="P:diphosphoinositol polyphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04666">
        <property type="entry name" value="NUDIX_DIPP2_like_Nudt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000002">
        <property type="entry name" value="diphosphoinositol polyphosphate phosphohydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047198">
        <property type="entry name" value="DDP-like_NUDIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12629">
        <property type="entry name" value="DIPHOSPHOINOSITOL POLYPHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12629:SF6">
        <property type="entry name" value="DIPHOSPHOINOSITOL POLYPHOSPHATE PHOSPHOHYDROLASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="12">
        <location>
            <begin position="17"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005005111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="180" mass="20411" checksum="46FDB469EFD8BB21" modified="2022-01-19" version="1">MMKFKPNQTRTYDREGYKKRAACLCFRSESEDEVLLVSSSRYPDQWIVPGGGMEPEEEPGGAAVREVYEEAGVKGKLGRLLGIFENQDRKHRTYVYVLTVTEILEDWEDSVNIGRKREWFKVEDAIKVLQCHKPVHAEYLEKLKLSCSPTNGNSVVPPLPDNNSLYVTSAQTSGLPSTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T1M0</accession>
    <name>A0A8C2T1M0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Protein O-mannosyl-transferase 1</fullName>
            <ecNumber evidence="4">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">POMT1</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2T1M0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005009228.1">
        <property type="protein sequence ID" value="ENSCJPP00005005733.1"/>
        <property type="gene ID" value="ENSCJPG00005005203.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158049"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001669">
        <property type="term" value="C:acrosomal vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031502">
        <property type="term" value="C:dolichyl-phosphate-mannose-protein mannosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016529">
        <property type="term" value="C:sarcoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd23281">
        <property type="entry name" value="beta-trefoil_MIR_POMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000012">
        <property type="entry name" value="Protein O-mannosyl-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF51">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="229"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="598"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="629"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="659"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="694"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="316"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="390"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="451"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00067952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005005733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="744" mass="84834" checksum="A57207476408716B" modified="2022-01-19" version="1">PSFIAYGRLEGVGLGQTFDRMLGFLKNPVVVTAEINLNLVVLTVMGLISRLWGLSYPRAVVFDEVYYGQFVSLYMKRIFFVDDSGPPLGHMLLALGGYLGGFDGNFLWNRIGAEYSINVPVWSLRFLPALAGALCIPLAYQILVELQFSHCAALGAALLILLENALITQSRFMLLESILIAFILLAVLSYLKFYNLQKHSSFSGRWWFWLLLTGVACSCAVGVKYMGLFTYMLLLAIAGLHFWHMLGDRNLSNVSLACHFLARGLTLLVIPVAMYLSFFYVHLTLLYRSGPHDQIMTSAFQASLEGGLARITQGQPLEVAYGSQITLRNVLGKPMQCWLHSHTNTYPIRYENGRGSSHQQQVTCYPFKDVNNWWIVKDPGMQQLVVSNPPRPVRHGHIVQLVHGITTRYLNTHDVAAPLSPHSQEVSCYIDYNISMPAQNLWRVEIVNRESDTDVWKTILSEVRFVHVNTSAVLKLSGASLPEWGYRQLEVVGEKLSKGYHQSMVWNVEEHRYGKSQEQKEREVELHSPTRMDISKNLSFMAKFTELQWKILTLKNEDTEHKYSSSALDWITMDTNIAYWLHPTSGAQIHLLGNVCTWASANIAAVVYVCLSLWYLIRRRRKIYDIPEDAWQLWVSAGQICVGGWVVNYLPFFLMEKTLFLYHYLPALTFQILLIPIVLQHLSDHLCRSLLSKSMFNALIVAWFSSVCFAYRTFSPVTYGEPLSVAELKELRWKDSWNILIRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T1W9</accession>
    <name>A0A8C2T1W9_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T1W9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005010826.1">
        <property type="protein sequence ID" value="ENSCJPP00005006956.1"/>
        <property type="gene ID" value="ENSCJPG00005006427.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00960000189447"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051117">
        <property type="entry name" value="TRG_var/const_region"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19256:SF65">
        <property type="entry name" value="T CELL RECEPTOR GAMMA CONSTANT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19256">
        <property type="entry name" value="T-CELL RECEPTOR GAMMA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="5"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="166" mass="19110" checksum="24C8F61E088D2F18" modified="2022-01-19" version="1">MVPTPQVFINLDQETPIQSPVSITKSQGNADLKCHFKDFSGNFDNTVIHWYQQKENKAPVRMIYFSAGRTFQDEGFQRHRYRIQTISGQKICTLTIRNIILDDAATYYCAYWDPHRGRSQMITTTNTSSAAHRSFGINQIILQRGYSSLQEGKLQWKVALQGISTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T236</accession>
    <name>A0A8C2T236_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WASH complex subunit 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">WASH complex subunit strumpellin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">WASHC5</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the strumpellin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015711756.1">
        <property type="nucleotide sequence ID" value="XM_015856270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T236"/>
    <dbReference type="Ensembl" id="ENSCJPT00005010136.1">
        <property type="protein sequence ID" value="ENSCJPP00005006424.1"/>
        <property type="gene ID" value="ENSCJPG00005006014.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107310533"/>
    <dbReference type="KEGG" id="cjo:107310533"/>
    <dbReference type="CTD" id="9897"/>
    <dbReference type="GeneTree" id="ENSGT00390000011137"/>
    <dbReference type="OrthoDB" id="565118at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071203">
        <property type="term" value="C:WASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140285">
        <property type="term" value="P:endosome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007040">
        <property type="term" value="P:lysosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090306">
        <property type="term" value="P:meiotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001556">
        <property type="term" value="P:oocyte maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040038">
        <property type="term" value="P:polar body extrusion after meiotic divisions"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031503">
        <property type="term" value="P:protein-containing complex localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051125">
        <property type="term" value="P:regulation of actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097494">
        <property type="term" value="P:regulation of vesicle size"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019393">
        <property type="entry name" value="WASH_strumpellin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15691">
        <property type="entry name" value="WASH COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15691:SF6">
        <property type="entry name" value="WASH COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10266">
        <property type="entry name" value="Strumpellin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1159" mass="133938" checksum="06BF9084B5CB75C2" modified="2022-01-19" version="1">MVDFLAENNLCGQAILRIVSCGNAIIAELLRLSEFIPGVFRLKDKADQQKYGDIIFDFSYFKGPEACEGKLEAKPELLDLDEEFRENNIEILTRFYLAFQSVHKYIVDLNRYLDDLNEGIYIQQTLETVLLNEDGKQLLCEALYLYGVMLLVIDQKIEGEVRERMLVSYYRYSAARSSADSNLDDICKLLRSTGYSSQPGAKRPPNYPESYFSRVPISETFISMVVGRLRSDDIYNQVSAYPLPEHRSTALATQAAMLYVILYFDASILHTQQAKMREIVDKYFPDNWVISIYMGITVNLAEAWEPYKAAKTALNYTLDIANVKEQANRYAAVTERVHTQVQQFLKEGCLREELVLDNIPKLLNCLRDCNVAIRWLMLHTADTACDPNNKRLRQIKDQILTDSRYNPKVLFQLLLDTAQFEFILKEMFKQMLSEKQAKWENYKKEGSERMTELADVFSGVKPLTRVEKNENLQAWFREISKQIMSLNYDDSTAAGRKTVQLIQALEEVQEFHQLETNLQVCQFLADTRKFLHQMIRTINIKEEVLITMQIVGDLSYAWQLIDSFTSIMQESIRVSPSMVTKLRATFLKLASALDLPLLRINQANSPDLLSVSQYYSGELVSYVRKVLQIIPESMFTSLLKIIKLQTHDIIEVPTRLDKDKLRDYAQLGPRYEVAKLTHAISIFTEGILMMKTTLVGIIKVDPKQLLEDGIRKELVKRVALALHRGLIFNPRAKPSELMPKLKEMAATMDGFHRSFEYIQDYVNIYGLKIWQEEVSRIINYNVEQECNNFLRTKIQDWQSMYQSTHIPIPKFTPVDESVTFIGRLCREILRITDPKITCYIDQMNTWYDVKTHQEVTSSRLFSEIQDTLGTFGLNGLDRLLCFMIVKELQNFLSMFQKNILRDRTVQDTLKALMNAVSPLKGIIANSNKVYSAAIAKTQKIWTAYLDSIMKVGQMQILRRQITNELNYSCRFDSKHLAAALENLNKAILADIEAHYQNPSLPYPKEDNTLLYEITAYLEAAGIHNPLNKIYITTKRLPYFPTVNFLFLISQFPKLQYSKNLGMVCKRPADQIDWLPLVLGLLTLLKQFHSRYTEQFLTLIGQFIRSTMEQCVSQKIPEMPADVVAALMFLEDYIRYTKLPRKVVEAHVPSFIFDEFRTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T358</accession>
    <name>A0A8C2T358_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="24">Acyl-coenzyme A thioesterase 13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="26">Hotdog-fold thioesterase superfamily member 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="25">Palmitoyl-CoA hydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="27">Thioesterase superfamily member 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="30" type="primary">ACOT13</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="30" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="30" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="30" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="22">Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels. Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates. Can also hydrolyze 3-hydroxyphenylacetyl-CoA and 3,4-dihydroxyphenylacetyl-CoA (in vitro). May play a role in controlling adaptive thermogenesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(9Z)-octadecenoyl-CoA + H2O = (9Z)-octadecenoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40139"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:40140"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>a fatty acyl-CoA + H2O = a fatty acid + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16781"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:77636"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:16782"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>butanoyl-CoA + H2O = butanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40111"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17968"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57371"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:40112"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>decanoyl-CoA + H2O = decanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40059"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:27689"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:61430"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:40060"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>dodecanoyl-CoA + H2O = dodecanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:30135"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18262"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57375"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:30136"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>hexadecanoyl-CoA + H2O = hexadecanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16645"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="EC" id="3.1.2.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:16646"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>hexanoyl-CoA + H2O = hexanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40115"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17120"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:62620"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:40116"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>octanoyl-CoA + H2O = octanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:30143"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25646"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57386"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:30144"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>tetradecanoyl-CoA + H2O = tetradecanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40119"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30807"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:40120"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="23">Homotetramer. Interacts with PCTP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytoskeleton</location>
            <location evidence="4">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T358"/>
    <dbReference type="Ensembl" id="ENSCJPT00005012005.1">
        <property type="protein sequence ID" value="ENSCJPP00005007842.1"/>
        <property type="gene ID" value="ENSCJPG00005007119.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000013934"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120163">
        <property type="term" value="P:negative regulation of cold-induced thermogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051289">
        <property type="term" value="P:protein homotetramerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000021">
        <property type="entry name" value="Acyl-coenzyme A thioesterase 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF1">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="THIOESTERASE SUPERFAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="29">
        <location>
            <begin position="87"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="28">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00050199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00052976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00058205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00064709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00067273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00075657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00081533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00083956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005007842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="175" mass="18540" checksum="770B20EC4FCAFCD0" modified="2022-01-19" version="1">HPPHPPPHAPPAGSVVRSAPPAPSRCGRSGSGMGSTRLTLEGLRDAMKYMLQSEGFDRVLGKVKLLSANPGKVVCELKVEEEHSNRFGTLHGGLTATLVDVVSTFALLYTERALPGVSVDMNITYASAAKVGEEVLITAQVLKQGRNLAFASVDLTNKATGKLIAQGRHTKYIGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T3A2</accession>
    <name>A0A8C2T3A2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Nuclear pore complex protein Nup155</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">155 kDa nucleoporin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Nucleoporin Nup155</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">NUP155</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Essential component of nuclear pore complex. Could be essessential for embryogenesis. Nucleoporins may be involved both in binding and translocating proteins during nucleocytoplasmic transport.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Nucleoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the non-repetitive/WGA-negative nucleoporin family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSCJPT00005012109.1">
        <property type="protein sequence ID" value="ENSCJPP00005007902.1"/>
        <property type="gene ID" value="ENSCJPG00005006933.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000016532"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome Z"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044611">
        <property type="term" value="C:nuclear pore inner ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0086014">
        <property type="term" value="P:atrial cardiac muscle cell action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035196">
        <property type="term" value="P:miRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006998">
        <property type="term" value="P:nuclear envelope organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036228">
        <property type="term" value="P:protein localization to nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000972">
        <property type="term" value="P:transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.450:FF:000001">
        <property type="entry name" value="Nuclear pore complex protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1880:FF:000001">
        <property type="entry name" value="Nuclear pore complex protein Nup155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.440:FF:000001">
        <property type="entry name" value="Nuclear pore complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1880">
        <property type="entry name" value="Nucleoporin, helical C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.440">
        <property type="entry name" value="Nucleoporin, helical domain, central subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.450">
        <property type="entry name" value="Nucleoporin, helical domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007187">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014908">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004870">
        <property type="entry name" value="Nucleoporin_Nup155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042533">
        <property type="entry name" value="Nucleoporin_Nup155_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042537">
        <property type="entry name" value="Nucleoporin_Nup155_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042538">
        <property type="entry name" value="Nucleoporin_Nup155_C_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10350">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10350:SF6">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03177">
        <property type="entry name" value="Nucleoporin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08801">
        <property type="entry name" value="Nucleoporin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="10" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like N-terminal" evidence="21">
        <location>
            <begin position="82"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like C-terminal" evidence="20">
        <location>
            <begin position="665"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="992"/>
            <end position="1019"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00058219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00068608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00077084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00078199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF03177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF08801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005007902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1396" mass="155025" checksum="D5C5F3CD2BDA2A7E" modified="2022-01-19" version="1">DPLPLCSPAAMPAAMSPTVPAGHEALEIAGRVIDRQIQDDRCYPDLSELLAVPAPGDPTVSGMTDMDYPLQGPGLLSIPNLPEISSVRRVPLPPELVEQFGHMQCNCMMGVFPEISRAWLTIDSDIFMWNYEDGGDLAYFDGLSETILAVGLVKPKAGIFQPHVRHLLVLATPVDIVILGLSCANTQTGTGSLNDSLSGGMQFLPDPLYSLPTDNTYISAITSTDNGRIFLAGKDGCLYEVAYQAEAGWFSQRCRKINHSKSTLSFLIPSLLQFTFSEDDPVVQIAIDNSRNILYTRSEKGVLQVYDLGQDGQGMARVTSLSQNAIVSAAGSIARTIDRSVFKPIVQIAVIENSESIDCQLLAITHAGVRLYFSTSQFKHPAARPSMLTLVHVRLPPGFSASSNVEKPSKVHRALYSKGVLLMAASENEDNDILWCINHDSFPFQKPMMETQMTTRVDGHSWALSAIDDFKVQKIVTPLNKDVIPITDSPIVVQQHMLPPKKFVLLSAQGSFMFHKLRPVDQLRHLLVSNTGGDGEDIERFFKLHQEDQACATCLILACSNAACDTEVSAWATRAFFRYGGEAQMRFPSALPPPSNVGPLLISPISSVPPLTVDSPYPSPSFLAAPGPGLQPTGMSTPIFASGNSVSHPGTSISSGMMGPEIVFSGRHNGICIYFARIIGNIWDGSMVVEKIFKSGNREVVTIESSVPSHVLECVLQELKGLQEFLDRNSQFATVGALGNPSTPANLQQRLLGFMRPDGGSSQQVQQELQRKYHAEAQLTEKNSLQGIQQLVRKTCQALALWKLLCEHQFSVVVGELQKELQEHLKMTAFKDLVIRDKELTGALIASLINCYIRDNAAVDGISAHLQDICPLLYSTDDAVCSKANELLQRSRQAQNKLEKEKMLRESLKEYQKISNQVDLANVCAQYRQVRFYEGVVELSLTAAEKKDPQGLGLHFYKNGEPEEDAVGLQAFQERLNSYKCITDTLQELVNQSKAAPQSPSVPKKPGPPVLSSDPNMLSNEEAGHHFEQMLKLAQRSTDELFSTALYNWLIQVDLADKLLQVTAPYLEPYLVRMTKIDQNKVRYMDLLWRYFEKNRNFSNAARVLAKLADLHSTEISLQQRLEYIARAILSAKSSTAISSIAADGEFLHELEEKMDVARIQLQIQETLQRQYSHHPSVQDAISQLDAELMDITKLYGEFADPFKLSECKLAIIHCAGHSDPILVQTLWQEIIEKELSDSVSLSSTDRMQALSLKMALLGKIYAGTPRYFPLDFLVQFLEQQVCALNWDVGFVTYTMQEIGVPLPRLLEVYDQLFKARDPYWNRMKKPLHLLECIHVLLSGYVQDPSRVLMRRRFTNVCLDAVSCYLVELQSMSPTLTVQTTIGNFKSLQANLERLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T3B9</accession>
    <name>A0A8C2T3B9_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Radial spoke head component 4A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">RSPH4A</name>
        <name evidence="7" type="synonym">RSPH6A</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T3B9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005011857.1">
        <property type="protein sequence ID" value="ENSCJPP00005007712.1"/>
        <property type="gene ID" value="ENSCJPG00005007028.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00500000044869"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001534">
        <property type="term" value="C:radial spoke"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035082">
        <property type="term" value="P:axoneme assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060294">
        <property type="term" value="P:cilium movement involved in cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22963">
        <property type="entry name" value="DD_CrRSP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006802">
        <property type="entry name" value="Radial_spoke"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13159:SF0">
        <property type="entry name" value="RADIAL SPOKE HEAD 6 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13159">
        <property type="entry name" value="RADIAL SPOKEHEAD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04712">
        <property type="entry name" value="Radial_spoke"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="288"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="482"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="583"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="290"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="427"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="484"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="620"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005007712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="639" mass="72530" checksum="F89FC34B984E3521" modified="2022-01-19" version="1">MCRRVVPKVKHSRIRRRSSAGGPAERLDTATTRTSTLRKAQGATLSKPSPKHTPHCSDSHQAEEVSMYQSYPAGGQEPRDAYQGYEGRDHYQDYEREHGPYLPHEPGYGLDQTDDQTPDPEHRMLAFQNAKAYMLQSSVTSGLNLYDHLVNVLIKILDERPTNPVDIFENISKDVKADQFQKKMDTLRDEPEILPSFEPAELRKNLFLKSDAGDEEQEEETGENPLPNMMETAFYFEQGGIGLSRDETYLIFLALKKLVTVQPIQTCRFWGRILGREKNYIIAEVQYREGEEEEEEKEEEDVIDEGDKETDEVEDEDEEKEKNEPPKSTYKPPPVIPKEENGTGTNKYIYFVCNEPGDPWVKLPPVTPAQIVCARKIKKFFTGRLDAPIVSFPPFPGNEANYLRAQIARISAGTHVSPLGYYRFAEEEGDEDEEGGGGDFEENPDFEPLPALEMVESLSTWVHHVPSILKQGRCVWFNPLQKSEEEEEAEEEEEEEKEEPEELQQEIGPPLLTPVSEDEGIQNVPAWTASVSAKLTPQYAIAILRSNRWPGAYAFACGTKFGNIYFGWGHKYSLGNLTPALPPPVQPEYPDGPEIKEATDPTVEEEQAFKAAQEEKDREGMEEEEEEEEEAEEEEGDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T407</accession>
    <name>A0A8C2T407_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">40S ribosomal protein S14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">RPS14</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the small ribosomal subunit. Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015731219.1">
        <property type="nucleotide sequence ID" value="XM_015875733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T407"/>
    <dbReference type="SMR" id="A0A8C2T407"/>
    <dbReference type="Ensembl" id="ENSCJPT00005011031.1">
        <property type="protein sequence ID" value="ENSCJPP00005007108.1"/>
        <property type="gene ID" value="ENSCJPG00005006550.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107320142"/>
    <dbReference type="KEGG" id="cjo:107320142"/>
    <dbReference type="CTD" id="6208"/>
    <dbReference type="GeneTree" id="ENSGT00390000000703"/>
    <dbReference type="OrthoDB" id="1677536at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048027">
        <property type="term" value="F:mRNA 5'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030218">
        <property type="term" value="P:erythrocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.80:FF:000018">
        <property type="entry name" value="40S ribosomal protein S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="entry name" value="Ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_uS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_uS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018102">
        <property type="entry name" value="Ribosomal_uS11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_uS11_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007176">
        <property type="entry name" value="PRK09607.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S14/30S RIBOSOMAL PROTEIN S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002131">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00054">
        <property type="entry name" value="RIBOSOMAL_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00045441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005007108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="151" mass="16273" checksum="4F4387F9FADAC278" modified="2022-01-19" version="1">MAPRKGKEKKEEQVISLGPQVAEGENVFGVCHIFASFNDTFVHVTDLSGKETICRVTGGMKVKADRDESSPYAAMLAAQDVAQRCKELGITALHIKLRATGGNRTKTPGPGAQSALRALARSGMKIGRIEDVTPIPSDSTRRKGGRRGRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T500</accession>
    <name>A0A8C2T500_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T500"/>
    <dbReference type="Ensembl" id="ENSCJPT00005011033.1">
        <property type="protein sequence ID" value="ENSCJPP00005007110.1"/>
        <property type="gene ID" value="ENSCJPG00005006557.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00910000148543"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005007110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="58" mass="6595" checksum="ACD991BAB50CF157" modified="2022-01-19" version="1">MRSQCVLGLRSFAAFAARLWSFVLYVLRRQVRTVSTGGAYQRVRYDVLPCPHPPATPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T604</accession>
    <name>A0A8C2T604_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Regulating synaptic membrane exocytosis 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">RIMS1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Synapse</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015714586.1">
        <property type="nucleotide sequence ID" value="XM_015859100.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005011914.1">
        <property type="protein sequence ID" value="ENSCJPP00005007762.1"/>
        <property type="gene ID" value="ENSCJPG00005007064.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107312061"/>
    <dbReference type="CTD" id="22999"/>
    <dbReference type="GeneTree" id="ENSGT00940000155134"/>
    <dbReference type="OrthoDB" id="420032at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048788">
        <property type="term" value="C:cytoskeleton of presynaptic active zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044325">
        <property type="term" value="F:transmembrane transporter binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060478">
        <property type="term" value="P:acrosomal vesicle exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048791">
        <property type="term" value="P:calcium ion-regulated exocytosis of neurotransmitter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903861">
        <property type="term" value="P:positive regulation of dendrite extension"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050806">
        <property type="term" value="P:positive regulation of synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065003">
        <property type="term" value="P:protein-containing complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048167">
        <property type="term" value="P:regulation of synaptic plasticity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000300">
        <property type="term" value="P:regulation of synaptic vesicle exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04031">
        <property type="entry name" value="C2A_RIM1alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04028">
        <property type="entry name" value="C2B_RIM1alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06714">
        <property type="entry name" value="PDZ_RIM-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000001">
        <property type="entry name" value="Regulating synaptic membrane exocytosis 3, isoform CRA_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000003">
        <property type="entry name" value="Regulating synaptic membrane exocytosis protein 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000003">
        <property type="entry name" value="Regulating synaptic membrane exocytosis protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000044">
        <property type="entry name" value="Regulating synaptic membrane exocytosis protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010911">
        <property type="entry name" value="Rab_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039032">
        <property type="entry name" value="Rim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054386">
        <property type="entry name" value="RIM_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12157">
        <property type="entry name" value="REGULATING SYNAPTIC MEMBRANE EXOCYTOSIS PROTEIN"/>
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    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
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            <begin position="22"/>
            <end position="171"/>
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            <begin position="83"/>
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            <begin position="596"/>
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            <begin position="733"/>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T609</accession>
    <name>A0A8C2T609_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Melanocortin 3 receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">MC3R</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_015881722.2"/>
    </dbReference>
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        <property type="protein sequence ID" value="ENSCJPP00005008032.1"/>
        <property type="gene ID" value="ENSCJPG00005007263.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="cjo:107323030"/>
    <dbReference type="CTD" id="4159"/>
    <dbReference type="GeneTree" id="ENSGT01140000282542"/>
    <dbReference type="OrthoDB" id="410721at2759"/>
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        <property type="component" value="Chromosome 20"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:melanocyte-stimulating hormone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0042923">
        <property type="term" value="F:neuropeptide binding"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032922">
        <property type="term" value="P:circadian regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045475">
        <property type="term" value="P:locomotor rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060259">
        <property type="term" value="P:regulation of feeding behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="7tmA_MC3R"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Melanocortin receptor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
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    </dbReference>
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        <property type="entry name" value="GPCR_Rhodpsn"/>
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        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
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        <property type="entry name" value="MC3-5R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002122">
        <property type="entry name" value="Mcort_3_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001671">
        <property type="entry name" value="Melcrt_ACTH_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22750">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
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    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
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    <dbReference type="PRINTS" id="PR00534">
        <property type="entry name" value="MCRFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00535">
        <property type="entry name" value="MELNOCORTINR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01061">
        <property type="entry name" value="MELNOCORTN3R"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="187"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="239"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="55"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005008032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="325" mass="36609" checksum="EB4B39E03F602C52" modified="2022-01-19" version="1">MNSTHFAFSFQPVLLNVTEDVNDSILSNRSSDGFCEQVFIKAEVFLTLGIISLLENILVILAVLKNGNLHSPMYFFLCSLAVADMLVSMSNALETIMIAILSNGYLVIDDHFIQHMDNVFDSMICISLVASICNLLVIAIDRYITIFYALRYHSIMTVKKALTLIVLIWIACIICGIIFIAYSESKTVIVCLITMFFTMLFLMASLYVHMFLFARLHVKRIAALPVDGVPSQRTCMKGAVTITILLGVFIVCWAPFFLHLILIISCPMNPYCVCYTSHFNTYLVLIMCNSVIDPLIYAFRSQEMRKTFKEIVCCCYSVSVGPCML</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T6W5</accession>
    <name>A0A8C2T6W5_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Sorting nexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">SNX33</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015728199.1">
        <property type="nucleotide sequence ID" value="XM_015872713.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T6W5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005013554.1">
        <property type="protein sequence ID" value="ENSCJPP00005009033.1"/>
        <property type="gene ID" value="ENSCJPG00005007999.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107318634"/>
    <dbReference type="KEGG" id="cjo:107318634"/>
    <dbReference type="CTD" id="257364"/>
    <dbReference type="GeneTree" id="ENSGT00940000160162"/>
    <dbReference type="OrthoDB" id="10254720at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036089">
        <property type="term" value="P:cleavage furrow formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044351">
        <property type="term" value="P:macropinocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045806">
        <property type="term" value="P:negative regulation of endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000009">
        <property type="term" value="P:negative regulation of protein localization to cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051044">
        <property type="term" value="P:positive regulation of membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000010">
        <property type="term" value="P:positive regulation of protein localization to cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017038">
        <property type="term" value="P:protein import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd07669">
        <property type="entry name" value="BAR_SNX33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11896">
        <property type="entry name" value="SH3_SNX33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000033">
        <property type="entry name" value="Sorting nexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000116">
        <property type="entry name" value="Sorting nexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000004">
        <property type="entry name" value="Sorting nexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037427">
        <property type="entry name" value="SNX33_BAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014536">
        <property type="entry name" value="Snx9_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019497">
        <property type="entry name" value="Sorting_nexin_WASP-bd-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45827">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45827:SF3">
        <property type="entry name" value="SORTING NEXIN-33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10456">
        <property type="entry name" value="BAR_3_WASP_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027744">
        <property type="entry name" value="Snx9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="11 12" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SH3" evidence="16">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="17">
        <location>
            <begin position="210"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR027744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR027744-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005009033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="554" mass="63085" checksum="7E85C6552FF19B28" modified="2022-01-19" version="1">MALRGRALYNFQSENKEEISIQENEELVVFSERSLDGWLQGRNSRGETGLFPASYVEIVRPRAGSGHTEGSGSPAGSPGHLHGFCAAPAGLSSQGSFEDDDDDDWDDWDDSCTVVEEPRGAAGTNGHPLAGTEPYGAPRIKPALERQDSVGSSKRGSVVGRNLNRFSCFVRSGVEAFILGDVPLMSKIAEVYGIEMGSKGPQWRANPHPFICSVEDPTKQTKFKGIKSYISYKLTPSNFNSPVYRRYKHFDWLYGRLLQKFPVISVPHLPEKQATGRFEEDFIEKRKRRLILWMEHMTSHPVLSQYEGFQHFLRCRDEKAWKQGKRKAEKDEMVGANFLLTIQIPTEHQDLQDVEDRVDAFKAFSKKMDDSVLQLTNVASELVRKHVGGFRKEFQKLGNAFQAISYSFQMDPPYSLDALNNAISHTGKTYEAVGEMFAEQPKNDLFLMLDTLSLYQGLLSNFPDIIHLQKGAFAKVKESQRMSDEGRMDQEEADGIRKRCRVVGFALQAEMNHFHERRVADFKRMMQSYLKQQIIFYQRVSQQLEKTLRMYDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T787</accession>
    <name>A0A8C2T787_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Heparan sulfate 2-O-sulfotransferase 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">2-O-sulfotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">HS 2-O-sulfotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Heparan sulfate 2-sulfotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">HS2ST1</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfotransferase 3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015725678.1">
        <property type="nucleotide sequence ID" value="XM_015870192.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T787"/>
    <dbReference type="Ensembl" id="ENSCJPT00005014068.1">
        <property type="protein sequence ID" value="ENSCJPP00005009406.1"/>
        <property type="gene ID" value="ENSCJPG00005008267.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107317467"/>
    <dbReference type="CTD" id="9653"/>
    <dbReference type="GeneTree" id="ENSGT00530000063408"/>
    <dbReference type="OrthoDB" id="10019582at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004394">
        <property type="term" value="F:heparan sulfate 2-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015012">
        <property type="term" value="P:heparan sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030202">
        <property type="term" value="P:heparin proteoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060676">
        <property type="term" value="P:ureteric bud formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000534">
        <property type="entry name" value="Heparan sulfate 2-O-sulfotransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007734">
        <property type="entry name" value="Heparan_SO4_2-O-STrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005331">
        <property type="entry name" value="Sulfotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12129">
        <property type="entry name" value="HEPARAN SULFATE 2-O-SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12129:SF17">
        <property type="entry name" value="HEPARAN SULFATE 2-O-SULFOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03567">
        <property type="entry name" value="Sulfotransfer_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00093670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00093675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005009406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="356" mass="41718" checksum="1DB6308C6AA0D50A" modified="2022-01-19" version="1">MGLLRIMLPPKLQLLAVLVFGVAVLFLENQIQKLEESRGKLERAIARHEVREIEQRHTADGPRQDVTLDEEDDVVIIYNRVPKTASTSFTNIAYDLCAKNRYHVLHINTTKNNPVMSLQDQVRFVKNVTSWKEMKPGFYHGHVSYLDFAKFGVKKKPIYINVIRDPIERLVSYYYFLRFGDDYRPGLRRRKQGDKKTFDECVAAGGSDCAPEKLWLQIPFFCGHSSECWNVGSRWALEQAKYNLINEYFLVGVTEELEDFIMLLEAALPRFFRGATELYRTGKKSHLRKTTEKKLPTKETIAKLQQSEIWKMENEFYEFALEQFQFVRAHAVREKDGELYILAQNFFYEKIYPKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T7V9</accession>
    <name>A0A8C2T7V9_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">mitogen-activated protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">MAPK11</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2T7V9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005014554.1">
        <property type="protein sequence ID" value="ENSCJPP00005009787.1"/>
        <property type="gene ID" value="ENSCJPG00005008561.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160790"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060348">
        <property type="term" value="P:bone development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060038">
        <property type="term" value="P:cardiac muscle cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071347">
        <property type="term" value="P:cellular response to interleukin-1"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071493">
        <property type="term" value="P:cellular response to UV-B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098586">
        <property type="term" value="P:cellular response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060044">
        <property type="term" value="P:negative regulation of cardiac muscle cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904784">
        <property type="term" value="P:NLRP1 inflammasome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001649">
        <property type="term" value="P:osteoblast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038066">
        <property type="term" value="P:p38MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032735">
        <property type="term" value="P:positive regulation of interleukin-12 production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070269">
        <property type="term" value="P:pyroptotic inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051403">
        <property type="term" value="P:stress-activated MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008352">
        <property type="entry name" value="MAPK_HOG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01773">
        <property type="entry name" value="P38MAPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0346">Stress response</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="1"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="76"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="144"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005009787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="423" mass="47402" checksum="099560251EDA879B" modified="2022-01-19" version="1">MAALRSCKMKLYVVTVLTPQVTDRRCVLKIRTNTQTREHFNLVATFGASDGFKTCPVIFITSVFPNKKRMRSGDRTDFMLSGEVPGAVGTPVPPGAPSERLAAPPAQPRPPRTAPRPGLSRSPSPPCSPTRHCPRPGPTRRFPLPSPSLPLAVPPPAGAGRARLAPRSPPRLRGGRRCCCLRRRRLRYDVRTRRLLPAGAQQDGVGGATALPEPLPRGLGRLRLRVILDFGLARQTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLKGKALFPGDDYIDQLKRIMEVVGTPSSELLKKISSEHARKYIESLPHMPQQDLKAVFRGANPLAVDLLEKMLILDSDKRITASAALAHPYFVQYHDPDDEPEAELYDESIENKERTIEEWKELTYEEVMSFKPPDLKMDSLEIEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T8C3</accession>
    <name>A0A8C2T8C3_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Histone H2B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC107308206</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 14">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the histone H2B family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015707398.1">
        <property type="nucleotide sequence ID" value="XM_015851912.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032298433.1">
        <property type="nucleotide sequence ID" value="XM_032442542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T8C3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005013718.1">
        <property type="protein sequence ID" value="ENSCJPP00005009158.1"/>
        <property type="gene ID" value="ENSCJPG00005008091.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107308206"/>
    <dbReference type="KEGG" id="cjo:107308206"/>
    <dbReference type="GeneTree" id="ENSGT01110000267181"/>
    <dbReference type="OrthoDB" id="9117938at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22910">
        <property type="entry name" value="HFD_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000003">
        <property type="entry name" value="Histone H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000558">
        <property type="entry name" value="Histone_H2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055333">
        <property type="entry name" value="HISTONE_H2B_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23428">
        <property type="entry name" value="HISTONE H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00621">
        <property type="entry name" value="HISTONEH2B"/>
    </dbReference>
    <dbReference type="SMART" id="SM00427">
        <property type="entry name" value="H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00357">
        <property type="entry name" value="HISTONE_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6 14" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11 14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="13 14" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="12 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="16">
        <location>
            <begin position="20"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005009158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="126" mass="13988" checksum="78666E3C72B5776E" modified="2022-01-19" version="1">MPEPAKSTSAPKKGSKKAVTKTQKKGDKKRHKSRKESYSIYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERLAVEASRLVQYNHHSTITSREVQTAVRLLLPGELAKHAVSEGTKAVTKYTSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T8F6</accession>
    <name>A0A8C2T8F6_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TBC1 domain family member 22A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TBC1D22A</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">May act as a GTPase-activating protein for Rab family protein(s).</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T8F6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005013776.1">
        <property type="protein sequence ID" value="ENSCJPP00005009206.1"/>
        <property type="gene ID" value="ENSCJPG00005008119.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159840"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071889">
        <property type="term" value="F:14-3-3 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.750:FF:000009">
        <property type="entry name" value="TBC1 domain family member 22A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000001">
        <property type="entry name" value="TBC1 domain family member 22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000004">
        <property type="entry name" value="TBC1 domain family, member 22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF255">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 22A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="5">
        <location>
            <begin position="223"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="144"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="150"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="162"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005009206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="535" mass="61904" checksum="93B8AE7DA45E0D10" modified="2022-01-19" version="1">MANDGGRKQFWKRSGTKVPGSIQHVYGAQHPPFDPLLHGTLIKPGSKPPTTPVKLKKVSTFQEFESNTSDAWDLGDDDDELLAIAAENLNTEVVMETAHKVIQNHSKLQEQHKFLEEHLQEEKQVESAELTSNVCGDNRLVKSVSEGHTSASSDNASENSSMQRSQSLPQTSTPPLVSGMADFNTSVTPALTEREASRLDKFKQLLAGPNTDLEELRKLSWSGIPKRVRPIAWKLLSGYLPANVDRRESTLQRKRKEYFAFVEQYYDSRNDESHQDTYRQIHIDIPRMSPEVLRLQPKVTEIFERILFIWAIRHPASGYVQGINDLVTPFFVVFVCEYIEEEEVENFDVSSLPEEVLQNIEADSYWCMSKLLDGIQDNYTFAQPGIQKKVKMLEELVSRIDEQVHRHLDQHEVKYLQFAFRWMNNLLMREVPLRCTIRLWDTYQSEPEGFSHFHLYVCAAFLVRWRKEILEEKDFQKNMSEENNTAVRMKMIKELLIFLQNLPTVHWGNEEISVLLAEAYRLKFAFADAPNHYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T8T0</accession>
    <name>A0A8C2T8T0_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Gamma-aminobutyric acid type A receptor subunit beta2</fullName>
        </submittedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Postsynaptic cell membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T8T0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005014894.1">
        <property type="protein sequence ID" value="ENSCJPP00005010006.1"/>
        <property type="gene ID" value="ENSCJPG00005008763.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154245"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004890">
        <property type="term" value="F:GABA-A receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000004">
        <property type="entry name" value="Gamma-aminobutyric acid receptor subunit beta-2 isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002289">
        <property type="entry name" value="GABAAb_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01160">
        <property type="entry name" value="GABAARBETA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0868">Chloride</keyword>
    <keyword evidence="7" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0770">Synapse</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="318"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="15">
        <location>
            <begin position="95"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005010006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="337" mass="38653" checksum="7A3889E64B73F277" modified="2022-01-19" version="1">MNIGYFRRCLTFEEVSSAISSSAIIPDGYTTDDIEFYWRGGDNAVTGVTKIELPQFSIVDYKLITKNVVFSTGAYPRLSLSFKLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFLALLEYALVNYIFFGRGPQRQKKAAEKAASANNEKLRMDVNKDRRIIGTYHCPEMYSTKMDPHENILLSTLEIKNEMAASEAVMGLGDPRSTMLAYDTSSIQYRKAGLPRHSFGRNALERHVAQKKSRLRRRASQLKITIPDLTDVNAIDRWSRIFFPVVFSFFNIVYWLYYVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T938</accession>
    <name>A0A8C2T938_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">F-box only protein 25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">FBXO25</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015714796.1">
        <property type="nucleotide sequence ID" value="XM_015859310.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015714797.1">
        <property type="nucleotide sequence ID" value="XM_015859311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T938"/>
    <dbReference type="Ensembl" id="ENSCJPT00005013897.1">
        <property type="protein sequence ID" value="ENSCJPP00005009294.1"/>
        <property type="gene ID" value="ENSCJPG00005008178.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107312148"/>
    <dbReference type="KEGG" id="cjo:107312148"/>
    <dbReference type="CTD" id="26260"/>
    <dbReference type="GeneTree" id="ENSGT00390000004915"/>
    <dbReference type="OrthoDB" id="9991467at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd22099">
        <property type="entry name" value="F-box_FBXO25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040394">
        <property type="entry name" value="FBX25/32"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13123:SF8">
        <property type="entry name" value="F-BOX ONLY PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13123">
        <property type="entry name" value="LD30288P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005009294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="369" mass="43230" checksum="985B966892578322" modified="2022-01-19" version="1">MPFLGQDWRSPGWRWVKTEDGWKRFEPFGAALQGGNSQLNDISHAVILTGDDDDEMYASEDCESAAKKRKKDHCRNNTDSQCFYRENWIYVHKESTRERHGYCTLGEAFNRLDFSSAIKDIRRFNYVVKLLQLIAKSQLTSLSGAAQKNYFSILDKIVRKVMEDHHNPRLIKDLLQDLSSTLCILIRGVGKSVLVGNINIWMCRLETIRLWQQQLKNLQMNKQVNDGLTLSDLPLHMLSNILHRFSDGWDIITLGQVTPTLYMLSEDRQLWKKLCQYHFAEKQFCRHLILSEKGHIDWKLMYFALQKYYPKKEQYGDTLHFCRHCSILFWKDYHLALLLKDSGHPCTASDPNTCLMPVSPQHFIDLFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TB54</accession>
    <name>A0A8C2TB54_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Pantothenate kinase 3</fullName>
            <ecNumber evidence="5">2.7.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Pantothenic acid kinase 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">PANK3</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the phosphorylation of pantothenate to generate 4'-phosphopantothenate in the first and rate-determining step of coenzyme A (CoA) synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16373"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the type II pantothenate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.33" evidence="5"/>
    <dbReference type="RefSeq" id="XP_015731435.1">
        <property type="nucleotide sequence ID" value="XM_015875949.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TB54"/>
    <dbReference type="SMR" id="A0A8C2TB54"/>
    <dbReference type="Ensembl" id="ENSCJPT00005014739.1">
        <property type="protein sequence ID" value="ENSCJPP00005009887.1"/>
        <property type="gene ID" value="ENSCJPG00005008662.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107320250"/>
    <dbReference type="KEGG" id="cjo:107320250"/>
    <dbReference type="CTD" id="79646"/>
    <dbReference type="GeneTree" id="ENSGT00940000156396"/>
    <dbReference type="OrthoDB" id="275583at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905502">
        <property type="term" value="F:acetyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004594">
        <property type="term" value="F:pantothenate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019842">
        <property type="term" value="F:vitamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd24137">
        <property type="entry name" value="ASKHA_NBD_PanK-II_Pank3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000025">
        <property type="entry name" value="pantothenate kinase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.510:FF:000001">
        <property type="entry name" value="pantothenate kinase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004567">
        <property type="entry name" value="Type_II_PanK"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00555">
        <property type="entry name" value="panK_eukar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12280">
        <property type="entry name" value="PANTOTHENATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12280:SF21">
        <property type="entry name" value="PANTOTHENATE KINASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03630">
        <property type="entry name" value="Fumble"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00055080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00060870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00068273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00075240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005009887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="370" mass="41211" checksum="3ABB13576E8BCB55" modified="2022-01-19" version="1">MKIKDAKKPSFPWFGMDIGGTLVKLAYFEPIDITAEEEQEEVESLKSIRKYLTSNVAYGSTGIRDVHLELKDLTIFGRRGNLHFIRFPTHDLPTFIQMGRDKNFSTLHTVLCATGGGAYKFEEDFRTIGNLQLHKLDELDCLVKGLLYIDSVSFNGQAECYYFENASEPERCQKMPFNLDDPYPLLVVNIGSGVSILSVHSKDNYKRVTGTSLGGGTFLGLCSLLTGCESFEEALEMASKGDSTHADKLVRDIYGGDYERFGLPGWAVASSFGNMIYKEKRETVSKEDLARAILVTITNNIGSIARMCAVNEKINRVVFVGNFLRVNTLSMKLLAYALDYWSKGQLKALFLEHEGYFGAVGALLGLPNFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TBQ0</accession>
    <name>A0A8C2TBQ0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Stanniocalcin-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">STC2</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Has an anti-hypocalcemic action on calcium and phosphate homeostasis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer; disulfide-linked.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the stanniocalcin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015731848.1">
        <property type="nucleotide sequence ID" value="XM_015876362.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TBQ0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005015024.1">
        <property type="protein sequence ID" value="ENSCJPP00005010103.1"/>
        <property type="gene ID" value="ENSCJPG00005008836.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107320463"/>
    <dbReference type="KEGG" id="cjo:107320463"/>
    <dbReference type="CTD" id="8614"/>
    <dbReference type="GeneTree" id="ENSGT00390000005989"/>
    <dbReference type="OrthoDB" id="8931566at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040015">
        <property type="term" value="P:negative regulation of multicellular organism growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046885">
        <property type="term" value="P:regulation of hormone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001256">
        <property type="term" value="P:regulation of store-operated calcium entry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004978">
        <property type="entry name" value="Stanniocalcin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11245">
        <property type="entry name" value="STANNIOCALCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11245:SF2">
        <property type="entry name" value="STANNIOCALCIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03298">
        <property type="entry name" value="Stanniocalcin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0372">Hormone</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034843350" description="Stanniocalcin-2" evidence="10">
        <location>
            <begin position="24"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="223"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="246"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="285"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005010103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="300" mass="32670" checksum="1A185E71B2D8F8D4" modified="2022-01-19" version="1">MCAGLRGELPALALLLLIARAVAAGTEATRPPEGQPERTPQQKGRLSLQNTAEIQHCLVNAGDVGCGVFECFENNSCEIRGLHEICMTFLHNAGKFDAQGKSFIKDALKCKAHALRHKFSCISRKCPAIKEMVFQLQRECYLKHDLCSAAKENVQVIVEMIHFKDLLQHEPYVDLVNILLTCGEEVKKAITRSVQAQCEQNWGSLCSILSFCTSSMHGDAVLGPEKKTGEASKAAAGRGDVLVPAEPEHRESSRAAKGERGTKGHLNAHARVKAGAHGPKGVHGIMDRTDELSDLSDIQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TCU4</accession>
    <name>A0A8C2TCU4_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peroxiredoxin like 2C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">PRXL2C</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015704806.1">
        <property type="nucleotide sequence ID" value="XM_015849320.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TCU4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005016258.1">
        <property type="protein sequence ID" value="ENSCJPP00005011078.1"/>
        <property type="gene ID" value="ENSCJPG00005009553.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107306276"/>
    <dbReference type="KEGG" id="cjo:107306276"/>
    <dbReference type="CTD" id="195827"/>
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        <property type="component" value="Chromosome Z"/>
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        <property type="term" value="P:positive regulation of glycolytic process"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Thioredoxin-like_sf"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PEROXIREDOXIN-LIKE 2C"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="AhpC-TSA_2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005011078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="222" mass="25068" checksum="C630BD0624EA75CC" modified="2022-01-19" version="1">MSRPPLCPVVQQVRPVSAAPRLEPVELREAAHCLVVDADGRRIPFGALYRRQKAVVVFVRNFLCYTCKEYVEDLAKVPRSYLQEANVRLIVIGQSSYHHIKPFCSLTGYTHEMYVDPQREIYKMLGMRRGEGNDVSVQSPHVKSSMLLGSIRSMWRAMTGPAFDFQGDPAQQGGTLILGPGNEVHFLHHDRNRMDHVPINSVLQMAGVKTVNFTNKPQIIDI</sequence>
</entry>
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    <accession>A0A8C2TEN5</accession>
    <name>A0A8C2TEN5_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Collagen type XXV alpha 1 chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">COL25A1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
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            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TEN5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005016205.1">
        <property type="protein sequence ID" value="ENSCJPP00005011048.1"/>
        <property type="gene ID" value="ENSCJPG00005009531.1"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
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        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="F:amyloid-beta binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="F:heparin binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:axonogenesis involved in innervation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="6-Phosphogluconate Dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Collagen"/>
    </dbReference>
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        <property type="entry name" value="Collagen_Structural_Proteins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37456:SF3">
        <property type="entry name" value="COLLAGEN ALPHA-1(XXV) CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SI:CH211-266K2.1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Collagen"/>
        <property type="match status" value="4"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
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        <location>
            <begin position="1"/>
            <end position="585"/>
        </location>
    </feature>
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        <location>
            <begin position="90"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="140"/>
            <end position="152"/>
        </location>
    </feature>
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        <location>
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    </feature>
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        </location>
    </feature>
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        <location>
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            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005011048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="612" mass="59306" checksum="4DB8DE37B1148E63" modified="2022-01-19" version="1">MGVAKSALQPGSRPREAVASSALGETAVKRGSLARGVVLPGSGRPSALTLLLSPHRNPTSTWQKSERREKRPQSATARQVLQGKEVSGAEEERLGPPGPKGEKGDQGDQGPRGLPGFPTVAALHSNQILTVKGDQGQAGPPGPPGPPGPRGPPGDTGKDGPRGMPGVPGEPGKPGEQGLAGPQGPPGQKGSVGVPGVPGKDGQMGEPGLPGVAGEKGAAGLKGDPGERGEKGDAGENGPKGDTGEKGDPGSSAAGIKGEPGESGRPGQKGEPGLPGLPGLPGIKGEPGFIGPQGEPGLPGLPGTKGDRGEAGPPGKGERGETGLPGPKGRTGEPGSRGPKGSKGDTGDRGDTGSTGPRGPPGQKGDQGATEIIDYNGNIHEALQGPPGPPGPQGLQGPKGEPGSPGIPGVDGEQGPKGSKGDMGEPGMHGEKGGIGLPGLPGANGVKGEKGDAGLPGAQGPSIIGPPGPPGPHGPPGPMGPHGLPGPKGEPGLNGLKGLKGEQGQKGDRGPLGLPGASGLDGKPGPRGVDGPVGPHGPAGPKGDRGEKGTVGDPGPRGPYGLPGKDGEPGLDGFPGPRGEKGEIGEKGEKVTTVLLTVAWFLGPVSSAVFIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TFL0</accession>
    <name>A0A8C2TFL0_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Diencephalon/mesencephalon homeobox 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">DMBX1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paired homeobox family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TFL0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005017133.1">
        <property type="protein sequence ID" value="ENSCJPP00005011759.1"/>
        <property type="gene ID" value="ENSCJPG00005010066.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155505"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000125">
        <property type="entry name" value="diencephalon/mesencephalon homeobox protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052488">
        <property type="entry name" value="DMBX_homeobox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003654">
        <property type="entry name" value="OAR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46639">
        <property type="entry name" value="DIENCEPHALON/MESENCEPHALON HOMEOBOX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46639:SF2">
        <property type="entry name" value="DIENCEPHALON_MESENCEPHALON HOMEOBOX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="OAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50803">
        <property type="entry name" value="OAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="126"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="OAR" evidence="11">
        <location>
            <begin position="401"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="7">
        <location>
            <begin position="128"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="186"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="216"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="260"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="295"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005011759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="424" mass="47047" checksum="95A51747D4B66493" modified="2022-01-19" version="1">MLPPGRWQLRRARKQRGGNADGWSREGRGAEPRPLPTRVPAPTAGGEASPPPQVDVAMQHYGVNGYSLHAMNSLSAMYNLHQQAAQQAQHAPDYRPSVHALTLAERLAGCTFQDIILEARYGSQHRKQRRSRTAFTAQQLEALEKTFQKTHYPDVVMRERLAMCTNLPEARVQVWFKNRRAKFRKKQRSLQKEQLQKQKDCEGSHSEGKTEPPVLETQSTIPDTEKTQSIPSEVSTDLNLTLSEQSASESAPEDQTDREEEFKSTLDEAKVDKSPGVDGKALNCKRASPKAESPISATVTPSSSSGLAQTHSYSSSPLSLFRLQEQFRQHMAATNNLVHYSSFEMGTPSAMPYLGMNVNMAPLSSLHCQSYYQSLSHAQQVWSSPILQASSSLPSLNSKTTSIENLRLRAKQHAASLGLDTLPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TG53</accession>
    <name>A0A8C2TG53_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mucin-5B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC107320658</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015732236.1">
        <property type="nucleotide sequence ID" value="XM_015876750.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TG53"/>
    <dbReference type="Ensembl" id="ENSCJPT00005017444.1">
        <property type="protein sequence ID" value="ENSCJPP00005011987.1"/>
        <property type="gene ID" value="ENSCJPG00005010233.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107320658"/>
    <dbReference type="KEGG" id="cjo:107320658"/>
    <dbReference type="GeneTree" id="ENSGT00960000187431"/>
    <dbReference type="OrthoDB" id="10055523at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039861">
        <property type="entry name" value="IMPG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12199">
        <property type="entry name" value="INTERPHOTORECEPTOR MATRIX PROTEOGLYCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12199:SF5">
        <property type="entry name" value="MUCIN-2-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034924908" evidence="4">
        <location>
            <begin position="24"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="773"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="725"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="28"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="143"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="381"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="481"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="522"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="74"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="166"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="222"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="481"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005011987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="957" mass="99302" checksum="F3333DAF116A0756" modified="2022-01-19" version="1">MERVPRLVAAAVLVGCCARLCPALGGGTGSTRGTAAPCAHPGQRCRTDPQHGAGWLQTEAELFPFPGTPPGTAEPPGTSSSPGEAGTGPAVRDGVSTEAQNSLSAGTTDAAADRDRTSPTRPGDSPAWGLTAVTVELSTAPAISAAPRPEPIGNEKAESAPASQRTLLHSLSHVTVSSSTGGQRGTPSTMRTEFTQSWGGSTSPSYLKPQGRGATILPSDSRAGTPQGHTTDSPMPGTSGTLPFVGGMQNLQSSPGELGRMHQVLAGTGPAGESHPLQGTTMAWLGPHATSHPSMLSPGVGGRGGLIWHPRGPGASTALLPMESHLPPDHSTTATATGVMSPGLEGAPDLTTEVLVLPSTQGPPGPNRDPMNQTWHISALPREAPTSPGPQLSLGLSPTADTPPVASPGHEHAVSPQVPVWAGDAEPWAVTAPLSTTLPAAPSSPLQPALTQPSSSPLLLSFAISSISSITTTTSITTTVASTATATATSTDTATSPTLLRDERTALPEPSTAACQGAVEELTRGPRVVPGSPHQPTDPPRDAESPQPQSSPTERPHAGPTCVTPNPAAAGRATPVFITEDQPPLLRASLLRVPCELALDMTFVPALRDPTSHERHVLLSGFNRTVTARLAAVPGFVRLEVTAVREGRARRVELRYDALFAAELVRAAALGALLDAALRSGGTTAVGTARVVRHEARAPEPCAALFSCPDGFACVVGSDGNATCTSLCHRDYCRNHGVCAHPRGRGPLCRCPAGSDVWFVGLRCERRVTLSGLLGAAAGALLGVVLLGVAVGAAVVRRFRALLREARAEQGRSSYRRFCRPDEAAVPHWARSWPGSGSSLDNPAFSRSEELLHLHLPDDGCCCRRDPLGAARCPEPPARGHGFQYGWDTSCSSVNEPMVDSGKASDISVSSWPVEPSPWAPFSLLQQLSRQQLHPGRRPRSFCDGMELSTLERSWTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TGC0</accession>
    <name>A0A8C2TGC0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 30">Platelet-derived growth factor receptor alpha</fullName>
            <shortName evidence="30">PDGF-R-alpha</shortName>
            <shortName evidence="30">PDGFR-alpha</shortName>
            <ecNumber evidence="4 30">2.7.10.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="28 30">Alpha platelet-derived growth factor receptor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="27 30">Alpha-type platelet-derived growth factor receptor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="44" type="primary">PDGFRA</name>
    </gene>
    <organism evidence="44 45">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="44" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="44" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="44" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="30">Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="30">Present in an inactive conformation in the absence of bound ligand. Binding of PDGFA and/or PDGFB leads to dimerization and activation by autophosphorylation on tyrosine residues.</text>
    </comment>
    <comment type="subunit">
        <text evidence="30">Interacts with homodimeric PDGFA, PDGFB and PDGFC, and with heterodimers formed by PDGFA and PDGFB. Monomer in the absence of bound ligand.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 30">Cell membrane</location>
            <topology evidence="2 30">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="38">Membrane</location>
            <topology evidence="38">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="30 38">Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="4 30"/>
    <dbReference type="RefSeq" id="XP_015717781.1">
        <property type="nucleotide sequence ID" value="XM_015862295.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015717782.1">
        <property type="nucleotide sequence ID" value="XM_015862296.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TGC0"/>
    <dbReference type="SMR" id="A0A8C2TGC0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005018182.1">
        <property type="protein sequence ID" value="ENSCJPP00005012567.1"/>
        <property type="gene ID" value="ENSCJPG00005010682.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107313741"/>
    <dbReference type="KEGG" id="cjo:107313741"/>
    <dbReference type="CTD" id="5156"/>
    <dbReference type="GeneTree" id="ENSGT00940000156021"/>
    <dbReference type="OrthoDB" id="9936425at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030054">
        <property type="term" value="C:cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005902">
        <property type="term" value="C:microvillus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990270">
        <property type="term" value="C:platelet-derived growth factor receptor-ligand complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160185">
        <property type="term" value="F:phospholipase C activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005018">
        <property type="term" value="F:platelet-derived growth factor alpha-receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048407">
        <property type="term" value="F:platelet-derived growth factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005161">
        <property type="term" value="F:platelet-derived growth factor receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038085">
        <property type="term" value="F:vascular endothelial growth factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005021">
        <property type="term" value="F:vascular endothelial growth factor receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030325">
        <property type="term" value="P:adrenal gland development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055003">
        <property type="term" value="P:cardiac myofibril assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060326">
        <property type="term" value="P:cell chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071230">
        <property type="term" value="P:cellular response to amino acid stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034614">
        <property type="term" value="P:cellular response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048701">
        <property type="term" value="P:embryonic cranial skeleton morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048557">
        <property type="term" value="P:embryonic digestive tract morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008210">
        <property type="term" value="P:estrogen metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="38">
        <source>
            <dbReference type="RuleBase" id="RU000311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="39">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="40">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="41">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="42">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="43">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="44">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005012567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="45">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1087" mass="122691" checksum="B2D6B7915A310B20" modified="2022-01-19" version="1">MGTPPGTFLILGCFLTGPLLTLCQLPLPTIVPDRNEMVVQLNSNFTLKCSGDSEVSWQYPVTEGSHRIDIRHEENNSGLFVTVLEVGNASAAHTGMYVCYYNHTQVEDGEVEGKDIYIYVPDPDMPFVPSLPEDQFILVEEGDPTVIPCRTSDPSAEVTLVNSLDKPVYAFYDSKQGFVGNFLAGPYTCKTTVKGMEFKSDEFLVYILRATSQLPVEIEALKTVYKTGETIVVTCVVFDNEVVNLQWNYPGKVKEKGLIKLDDIKVPSQKLVYTLTIPDASVKDTGDYECTARHATKEVKENKKVVITVHDKGFIHLEPQFSPLEAVNLHEVKNFVVDVQAYPAPKMYWLKDNVTLIENLTEIVTSSNRVQETRFQSVLKLIRAKEEDSGYYTLVAENEDEVKRYTFSLLIQVPALILDLVDDHQGSTGRQTVRCLAEGTPLPDVEWLVCKDIKKCSNDTSWTLLTSNVSDIHMEAHLDEKNMVESQVTFQKVEETLAVRCVARNDLGAVTRELKLVAPTLRSELTVAAAVLVLLVIVIISLIVLVIIWKQKPRYEIRWRVIESISPDGHEYIYVDPMQLPYDSSWEFPRDGLVLGRILGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDNFLSRHPEKPKKDMDIFGMNPADESTRSYVILSFENTGEYMDMKQADTTQYVPMLERKEGSKYSDIQRSVYDRPASYKKKSLSESEVNYLLSDDSSEDLSLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATNEVYEIMVKCWNSEPEKRPSFYHLSEIVESLLPGQYKKSYEKIHLDFLKSDHPAVTRMRGDCDNTYIGVTYKNEDKLKDRESGFDEQRLSADSGYIIPLPDIDPVSEDELGKRNRHSSQTSEESAIETGSSSSTFIKREDETIEDIDMMDDIGIDSSDLVEDSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TH31</accession>
    <name>A0A8C2TH31_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein-serine/threonine kinase</fullName>
            <ecNumber evidence="11">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">PDK4</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ATP = O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23052"/>
            <dbReference type="Rhea" id="RHEA-COMP:13689"/>
            <dbReference type="Rhea" id="RHEA-COMP:13690"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer. Interacts with the pyruvate dehydrogenase complex subunit DLAT, and is part of the multimeric pyruvate dehydrogenase complex that contains multiple copies of pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (DLAT, E2) and lipoamide dehydrogenase (DLD, E3).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="11"/>
    <dbReference type="RefSeq" id="XP_015709133.1">
        <property type="nucleotide sequence ID" value="XM_015853647.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TH31"/>
    <dbReference type="Ensembl" id="ENSCJPT00005019541.1">
        <property type="protein sequence ID" value="ENSCJPP00005013634.1"/>
        <property type="gene ID" value="ENSCJPG00005011473.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107309122"/>
    <dbReference type="KEGG" id="cjo:107309122"/>
    <dbReference type="CTD" id="5166"/>
    <dbReference type="GeneTree" id="ENSGT01030000234646"/>
    <dbReference type="OrthoDB" id="241648at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004740">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071398">
        <property type="term" value="P:cellular response to fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042593">
        <property type="term" value="P:glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008286">
        <property type="term" value="P:insulin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000811">
        <property type="term" value="P:negative regulation of anoikis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072593">
        <property type="term" value="P:reactive oxygen species metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045124">
        <property type="term" value="P:regulation of bone resorption"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042304">
        <property type="term" value="P:regulation of fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046320">
        <property type="term" value="P:regulation of fatty acid oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006885">
        <property type="term" value="P:regulation of pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010510">
        <property type="term" value="P:regulation of pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd16929">
        <property type="entry name" value="HATPase_PDK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.20:FF:000001">
        <property type="entry name" value="[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000007">
        <property type="entry name" value="Mitochondrial pyruvate dehydrogenase kinase isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF22">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE ISOZYME 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Histidine kinase" evidence="12">
        <location>
            <begin position="253"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005013634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="416" mass="46948" checksum="C006F021484C9CE4" modified="2022-01-19" version="1">MKAARIALRTAVPLTGSGSGSVRSSRLPREVEQFSRFSPSPLSIKQLLDFGSTNGCERTSFAFLRQELPVRFANILREIELLPDKLLSTPSVQLVKSWYIQSLMELVEFHQKNPNDQKVLSDFIDTLIRVRNRHHDVIPTMAQGVIEYKDTFKVDPVTNQNIQYFLDRFYMSRISTRMLMNQHTLLFDDKSGSGHPRHIGSIDPCCDVVEVVNDAFQSSKMLCDQYYLTSPELKLNQVNGKFPGEPINIVYVPSHLFHMLFELFKNSMRATVEFQENSPSLSPVEVTVVLGQEDLAIKISDRGGGVPVRKIEQLFSYMYSTAPRPTMDDGRQTPLAGFGYGLPISRLYAKYFQGDLNLYSICGYGTDAIIYLKALSTESVEKLPVFNKSASKHYQTTSEAGDWCIPSKGPRQTATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2THX2</accession>
    <name>A0A8C2THX2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">E3 ubiquitin-protein ligase TRIM23</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="26">ADP-ribosylation factor domain-containing protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="25">GTP-binding protein ARD-1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">RING-type E3 ubiquitin transferase TRIM23</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="24">Tripartite motif-containing protein 23</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="33" type="primary">TRIM23</name>
    </gene>
    <organism evidence="33 34">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="33" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="33" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="33" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="19">Acts as an E3 ubiquitin-protein ligase. Plays an essential role in autophagy activation during viral infection. Mechanistically, activates TANK-binding kinase 1/TBK1 by facilitating its dimerization and ability to phosphorylate the selective autophagy receptor SQSTM1. In order to achieve this function, TRIM23 mediates 'Lys-27'-linked auto-ubiquitination of its ADP-ribosylation factor (ARF) domain to induce its GTPase activity and its recruitment to autophagosomes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="21">Homodimer. Interacts with PSCD1. Interacts with UBE2D2. Interacts with TBK1 (via N-terminal kinase domain) and p62/SQSTM1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Lysosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="20">In the C-terminal section; belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="RefSeq" id="XP_015704023.1">
        <property type="nucleotide sequence ID" value="XM_015848537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2THX2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005018601.1">
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    <sequence length="580" mass="64132" checksum="C8F94DB8511D36E3" modified="2022-01-19" version="1">MAALAVNKAAAAAGPDGGRGAGNSWGPTGAAVKVLECGVCEDVFSLQGDKVPRLLLCGHTVCHDCLTRLPLHGRAVRCPFDRQVTELGDSGVWGLKKNFALLELLERLQNGPPGQCGTAEEAIGLSGESIIRCDEDEAHVASVYCTVCATHLCADCSQLTHSTKTLAKHKRVPLADKPHEKTMCSQHQVHAIEFVCLEEDCQASPLMCCVCKEYGKHQGHKHSVLEPEANQIRASILDMAHCIRTFTEEISDYSRKLVGIVQHIEGGEQIVEDGVGMAHTEHVPGTAENARSCVRAYFSDLHETLCRQEEMALSVVDAHVREKLIWLRQQQEDMTILLSQVSTACLHCEKTLQQDDCRVVLAKQEITRLLETLQKQQQQFTELADHVQLDASIPVTFTKDNRVHIGPKMEIRVVTLGLDGAGKTTILFKLKQDEFMQPIPTIGFNVETVEYKNLKFTIWDVGGKHKLRPLWKHYYLNTQAVVFVVDSSHRDRVSEAHSELAKLLTEKELRDALLLIFANKQDVAGALSAEEITELLSLHKLCCGRNWYIQGCDARSGTGLFEGLDWLSRQLVAAGVLDVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2THY3</accession>
    <name>A0A8C2THY3_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tumor protein D52</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">TPD52</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TPD52 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2THY3"/>
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        <property type="protein sequence ID" value="ENSCJPP00005014111.1"/>
        <property type="gene ID" value="ENSCJPG00005011814.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155294"/>
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        <property type="component" value="Chromosome 2"/>
    </dbReference>
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        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030183">
        <property type="term" value="P:B cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007327">
        <property type="entry name" value="TPD52"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19307">
        <property type="entry name" value="TUMOR PROTEIN D52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19307:SF12">
        <property type="entry name" value="TUMOR PROTEIN D52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04201">
        <property type="entry name" value="TPD52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="196"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="56"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005014111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="233" mass="25242" checksum="7D6197C38013442E" modified="2022-01-19" version="1">MEPHGEPGVDRTYLYLSPGINLTPPGSPTLTKSGLLRTDSIPEVGEDAAATVGMSETLSEEEQNELRKELAKVEEEIQTLSQVLAAKEKHLAEIKRKLGINSLQELKQNITKSWQDVTSTAAYKKTSETLSQAGQKASAAFSSVGSVLSKKFEDVKLQAFSHSFSIRSIQHSISMPIMRNSPTFKSFEEKVETLKSKVGGSKPASGDFGEVLNSAANASATETIAEETQEETH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TKI8</accession>
    <name>A0A8C2TKI8_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Leucine-rich repeat-containing protein 21</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Photoreceptor-associated LRR superfamily protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Retina-specific protein PAL</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="primary">LRIT1</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Photoreceptor synaptic protein essential for normal vision. Involved in synapse formation in cone photoreceptor cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Dendrite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Endomembrane system</location>
            <topology evidence="16">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015721555.1">
        <property type="nucleotide sequence ID" value="XM_015866069.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TKI8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005021615.1">
        <property type="protein sequence ID" value="ENSCJPP00005015221.1"/>
        <property type="gene ID" value="ENSCJPG00005012640.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107315575"/>
    <dbReference type="KEGG" id="cjo:107315575"/>
    <dbReference type="CTD" id="26103"/>
    <dbReference type="GeneTree" id="ENSGT00940000156033"/>
    <dbReference type="OrthoDB" id="9229163at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043083">
        <property type="term" value="C:synaptic cleft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007602">
        <property type="term" value="P:phototransduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099536">
        <property type="term" value="P:synaptic signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000058">
        <property type="entry name" value="immunoglobulin superfamily containing leucine-rich repeat protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000744">
        <property type="entry name" value="Leucine rich repeat, Ig-like and transmembrane domains 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000928">
        <property type="entry name" value="Leucine rich repeat, Ig-like and transmembrane domains 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050467">
        <property type="entry name" value="LRFN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45842:SF9">
        <property type="entry name" value="LEUCINE-RICH REPEAT, IMMUNOGLOBULIN-LIKE DOMAIN AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45842">
        <property type="entry name" value="SYNAPTIC ADHESION-LIKE MOLECULE SALM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="10 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="6 23" id="KW-0732">Signal</keyword>
    <keyword evidence="5 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="14" id="KW-0844">Vision</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034099674" description="Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 1" evidence="23">
        <location>
            <begin position="23"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="527"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="24">
        <location>
            <begin position="254"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="25">
        <location>
            <begin position="430"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00046288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00058974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00068065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00075045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00079569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00080094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="626" mass="68652" checksum="C0900C032D075FE4" modified="2022-01-19" version="1">MWITVTLLCCLVLGGLPWAGTSCPSQCSCAFHSLNEGTKARMVLCNDPEMTLTPVNIPVDTFKLRIEKTAIRRVPGEAFHALHNLEYLWLPYNSLASLSGITFKGLRHLLELRLDGNNLISFPWETLSDMPQLRLLDLHSNELTSVPPDAARYIKNITYLDLSSNKLMTLPQALISTWANLQAVPYFPNDNSKIILGLQDNPWACDCSLYEMVHFLNFQSPNIAFIEPRLKCFTPRSLAGVFFSQVELRKCQSPVVHTSVAKVKTILGSTVLLRCGTTGVPIPELSWRRADGAPLNGTVHQEISSDGMSWSILGLPVVSYLDSGEYICKAKNFLGATEAFISLIIMDSESTDDPNSNAKGTWNGKASGMEAAAYNDKLVARYVITTSTMPTLGAGAGTGEDLLIPAGAKDSNPQNLLVSPPTGQQEPERIVRSVRVLGDTDQSVTLVWKAPLAKNTTVFSVLYAVFGERDMRRINVEPGKTKVNIYGLLPKTKYIVCVCVKGLIPRKEQCIIFSTDEVASAGGTQKLINVVVISVACVIAVPLTLVVCCGALKRRCKKCFVRKPKEIQESYVTFESLSPGAKVKGVEGEYLTRHTPDESNRLLSARSSVDSEAIPKIEGQPNEYFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TKP0</accession>
    <name>A0A8C2TKP0_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Family with sequence similarity 43 member A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FAM43A</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015727412.1">
        <property type="nucleotide sequence ID" value="XM_015871926.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TKP0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005021327.1">
        <property type="protein sequence ID" value="ENSCJPP00005015002.1"/>
        <property type="gene ID" value="ENSCJPG00005012479.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107318281"/>
    <dbReference type="KEGG" id="cjo:107318281"/>
    <dbReference type="CTD" id="131583"/>
    <dbReference type="GeneTree" id="ENSGT00940000161593"/>
    <dbReference type="OrthoDB" id="5962185at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="CDD" id="cd01214">
        <property type="entry name" value="PTB_FAM43A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051133">
        <property type="entry name" value="Adapter_Engulfment-Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033930">
        <property type="entry name" value="FAM43A/B_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11232">
        <property type="entry name" value="PHOSPHOTYROSINE INTERACTION DOMAIN-CONTAINING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11232:SF36">
        <property type="entry name" value="PROTEIN FAM43A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14719">
        <property type="entry name" value="PID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PID" evidence="2">
        <location>
            <begin position="64"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="326"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="362" mass="39797" checksum="52AEC29678FE3596" modified="2022-01-19" version="1">MLPWKRSKVELVPGEARRQSKPKGYAVSVHYSALTSLARACPESALHRVGSMFRSKRRKFRVTSEDPTYTVLYLGNATTIQSKGEGCTDLAVCKIWSKSEAGRQGTKMKLTISAQGIRMAHAEDKGLRRPGHLYLLHRVTYCVADPRLPRVFAWIYRHELKHKAVMLRCHAVLVSKPEKAKAMALLLYQTSATALAEFRRLKKRDDARHQQQQLVGEQSIPLVPLRKLLNGQCCYKPPVERSRSAPKLGSITEDLVGEEQEERAMHCECEDILEALGEPEGELLRAGTGRGEGAELGRLLRDLGELSLGNDLSSLRADLGVRRLLSGESTGSESSLESTGPDGAAPPCNGADQPPPGDPESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TMJ6</accession>
    <name>A0A8C2TMJ6_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family. Mas subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TMJ6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005022296.1">
        <property type="protein sequence ID" value="ENSCJPP00005015782.1"/>
        <property type="gene ID" value="ENSCJPG00005013028.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234639"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000193">
        <property type="entry name" value="Mas-related G-protein coupled receptor member E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026234">
        <property type="entry name" value="MRGPCRFAMILY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11334:SF68">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11334">
        <property type="entry name" value="MAS-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02108">
        <property type="entry name" value="MRGPCRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="188"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="227"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="52"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="325" mass="35792" checksum="17A75ECD9028A500" modified="2022-01-19" version="1">MGCKASDPFVPIPTISAGSEAVVLGCGSLLVDVFDAAVDGATLLISLCGLVGNGAVLWLLGCRIRRNPVTVYVLNLAVADFTFLLFMLTYTLLYFLKDLSCFMLPISVRHLVSLLLLSLFAHNMGMYLLAAVSIERCASAFCSGRTQCHRPQHLSAVVCALLWVLSITVITTVTSLCLSHQHEQCRLALIAMYVLNFLLFAPSMVISNIILLIKVLCSSMHRQHRRLYIVIFLTVLFFLLFGVPLSVWNFMQHFSFDPPGHHQVFFLLACINSSINPFIYVLVGIGKRHCSLASLQVAFQRVFEDLGDDGVGSNNSMMHTLSSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TN73</accession>
    <name>A0A8C2TN73_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Nardilysin convertase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">NRDC</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015726051.1">
        <property type="nucleotide sequence ID" value="XM_015870565.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TN73"/>
    <dbReference type="Ensembl" id="ENSCJPT00005020301.1">
        <property type="protein sequence ID" value="ENSCJPP00005014218.1"/>
        <property type="gene ID" value="ENSCJPG00005011887.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107317638"/>
    <dbReference type="KEGG" id="cjo:107317638"/>
    <dbReference type="CTD" id="4898"/>
    <dbReference type="GeneTree" id="ENSGT00940000155026"/>
    <dbReference type="OrthoDB" id="4953at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061133">
        <property type="term" value="F:endopeptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051044">
        <property type="term" value="P:positive regulation of membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032760">
        <property type="term" value="P:positive regulation of tumor necrosis factor production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903265">
        <property type="term" value="P:positive regulation of tumor necrosis factor-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000005">
        <property type="entry name" value="nardilysin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050626">
        <property type="entry name" value="Peptidase_M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032632">
        <property type="entry name" value="Peptidase_M16_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690:SF18">
        <property type="entry name" value="INSULIN-DEGRADING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690">
        <property type="entry name" value="NARDILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16187">
        <property type="entry name" value="Peptidase_M16_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="9">
        <location>
            <begin position="210"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="10">
        <location>
            <begin position="365"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 middle/third" evidence="11">
        <location>
            <begin position="556"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="10">
        <location>
            <begin position="842"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="66"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="136"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="167"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005014218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1154" mass="131676" checksum="8F1B1B12FE5C8F5D" modified="2022-01-19" version="1">MRSVPRRLLAALARRCRLARPGCERARPAAPVRGSSRWLWRCWAVAMPGRTRAASEFGCPELSVGQQVGASGRDAGGRSPHGEEEERGELGGNSGDPDIVKSPSDPKQYRYIKLQNGLCALLISDLNYLDDAPCALSSEDEEEEDESEGESDEDDSGAEIEDGREGFDEDCDEGDEDDDSEEGNEDFNDPDDSELEELAEKEETRKRGCTEKQSAAALCVAVGSFSDPEDLPGLAHFLEHMVFMGSSKYPDENGFDAFLKKHGGSDNASTDCERTVFQFDVQRKYFKEALDRWAQFFIHPLMIRDAIDREVEAVDSEYQLARPSDANRKEMLFGSLARPGHPMKKFFWGNADTLKHEPIKNNIDTYTRLRDFWQRHYSAHYMTLVVQSKETLDTLEKWVTEIFSEIPNNGLPKPSFAHLTQPFDTPEFHKLYRVVPIRKVHSLSITWALPPQEEYYRVKPLHYISWLVGHEGKGSVLSFLRKKFWALALYGGNGETGFEQNSTYSIFSISVTLTDEGYKHFYEVAHVVFQYVKMLQQRGPDKRIWEEIQKIEANEFHYQEQTDPVDYVESLCENMQLYPKEDFLTGDQLLFEYKPEIIADALNQLSPQRANLVLLSAANEGQCHLKERWFGTQYSMEDIDKYWSDLWASDFELNQDLHLPEENKYIATDFALKAADCPDTEYPVKAVSTQQGCLWYRKDDKFKIPKGYVRFHLISPLIQRSAENIVLFDTFVNILSHNLGEPAYEADVAQLEYKLVAGEHGLIIRVKGFNHKLPLLFQLIIDYLTDFSFTPAVFEMITEQLKKTYFNILIKPETLAKDVRLLILEHGRWSMIDKYQTLMKGLSIEALSSFVKAFKSQLFVEGLVQGNFTSREAKDFLNYVVQKLQFAPLAHPCPVQFRVVDLPNTHLLCKVKTLNRGDANSEVTVYYQSGARSLREYTLMELLVMHMEEPCFDFLRTKQTLGYHVYPTCRNTSGILGFSVTVATQATKYNSELVDKKIEEFLSCFGDKIKHLTEEAFSTQVTALIKLKECEDSHLGEEVDRNWNEVVTQQYLFDRLAREIEALKSVTKSDLVSWFQTHRSSKKKVLSVHVVGCGKHEGDAEVSSASEAQNSSSGEIPHLNFLPPSSLMADVTSIKDIKAYTSTLNVLPYHKILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TNA6</accession>
    <name>A0A8C2TNA6_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyclic AMP-dependent transcription factor ATF-4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Activating transcription factor 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ATF4</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015715878.1">
        <property type="nucleotide sequence ID" value="XM_015860392.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TNA6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005022793.1">
        <property type="protein sequence ID" value="ENSCJPP00005016182.1"/>
        <property type="gene ID" value="ENSCJPG00005013316.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107312723"/>
    <dbReference type="KEGG" id="cjo:107312723"/>
    <dbReference type="CTD" id="468"/>
    <dbReference type="GeneTree" id="ENSGT00530000063801"/>
    <dbReference type="OrthoDB" id="5847285at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990590">
        <property type="term" value="C:ATF1-ATF4 transcription factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990589">
        <property type="term" value="C:ATF4-CREB1 transcription factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990617">
        <property type="term" value="C:CHOP-ATF4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990037">
        <property type="term" value="C:Lewy body core"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035497">
        <property type="term" value="F:cAMP response element binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008140">
        <property type="term" value="F:cAMP response element binding protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043522">
        <property type="term" value="F:leucine zipper domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990841">
        <property type="term" value="F:promoter-specific chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061629">
        <property type="term" value="F:RNA polymerase II-specific DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030282">
        <property type="term" value="P:bone mineralization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042149">
        <property type="term" value="P:cellular response to glucose starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990253">
        <property type="term" value="P:cellular response to leucine starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032922">
        <property type="term" value="P:circadian regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035162">
        <property type="term" value="P:embryonic hemopoiesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160144">
        <property type="term" value="P:GDF15-GFRAL signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140468">
        <property type="term" value="P:HRI-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070059">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070982">
        <property type="term" value="P:L-asparagine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070309">
        <property type="term" value="P:lens fiber cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097250">
        <property type="term" value="P:mitochondrial respirasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042789">
        <property type="term" value="P:mRNA transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120163">
        <property type="term" value="P:negative regulation of cold-induced thermogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903377">
        <property type="term" value="P:negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036499">
        <property type="term" value="P:PERK-mediated unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070169">
        <property type="term" value="P:positive regulation of biomineral tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043525">
        <property type="term" value="P:positive regulation of neuron apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000120">
        <property type="term" value="P:positive regulation of sodium-dependent phosphate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905461">
        <property type="term" value="P:positive regulation of vascular associated smooth muscle cell apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010575">
        <property type="term" value="P:positive regulation of vascular endothelial growth factor production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045667">
        <property type="term" value="P:regulation of osteoblast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048167">
        <property type="term" value="P:regulation of synaptic plasticity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd14692">
        <property type="entry name" value="bZIP_ATF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000021">
        <property type="entry name" value="Cyclic AMP-dependent transcription factor ATF-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044">
        <property type="entry name" value="ACTIVATING TRANSCRIPTION FACTOR ATF 4/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044:SF2">
        <property type="entry name" value="CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="13">
        <location>
            <begin position="279"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="207"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="286"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="207"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="229"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005016182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="354" mass="39117" checksum="8833F193E1A0D12F" modified="2022-01-19" version="1">MSLLNNEMLLGESSPLSQPCLVAEEGLGLLDDYLEVAEPLGSHGFSSDKAKAVSSNWLTVDSLGNTIDSSQEDAFSGMEWMVEKMDLKEFDFDALLGMEHLEATVSPDDLMATLEDTCDLLFNPTTQEFHNKEPPLIPDLITNLPESPIGVDPMAPLGSLWPFPLSPGSLTSVPDHSFSLELGSEVDVLEGERKQEAPTFLVVITKSEKEEENHSDDSGICMSPDSYLGTPQHSPTNSLGSPNDNQFPADATRGSLRSKPYDHPAEKVVSAKVKGEKKIDKKLKKMEQNKTAATRYRQKKRAEQEALSGECRDLEQKNQALKEKADSLSKEIQYLKDLIEEVRKAKVKRARVPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TNF8</accession>
    <name>A0A8C2TNF8_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Prolactin regulatory element binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">PREB</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TNF8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005020417.1">
        <property type="protein sequence ID" value="ENSCJPP00005014326.1"/>
        <property type="gene ID" value="ENSCJPG00005011968.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000018031"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051020">
        <property type="term" value="F:GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048208">
        <property type="term" value="P:COPII vesicle coating"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003400">
        <property type="term" value="P:regulation of COPII vesicle coating"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045260">
        <property type="entry name" value="Sec12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23284">
        <property type="entry name" value="PROLACTIN REGULATORY ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23284:SF0">
        <property type="entry name" value="PROLACTIN REGULATORY ELEMENT-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="3 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="153"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="101"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005014326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="214" mass="22763" checksum="A16BD6615C54DAEC" modified="2022-01-19" version="1">AMAPRPTELYRAPFPLYTVRLHPRRGLAITAGGGGAAKTGIGNGVHFLRLEQIGGRLSASLLHCHDTETRATMSMAISGDFIAAGQDHSCHILRLCVPTAGKGGAAEEKGPRRRKGGTGPAERGETRSDGGEVSVESLHRVRTDFSPDALQKAVRFSADGTVLVTGGADGFVRLWEFPSMKKALEFKAHDGEIEDITLGPDNKVGGGRRVPGRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TPW2</accession>
    <name>A0A8C2TPW2_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Disco interacting A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">DIP2A</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Neuron projection</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DIP2 family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSCJPT00005021168.1">
        <property type="protein sequence ID" value="ENSCJPP00005014926.1"/>
        <property type="gene ID" value="ENSCJPG00005011865.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182997"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05905">
        <property type="entry name" value="Dip2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000003">
        <property type="entry name" value="DIP2 disco-interacting protein 2 homolog A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000001">
        <property type="entry name" value="DIP2 disco-interacting protein 2 homolog C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000002">
        <property type="entry name" value="Disco interacting protein 2 homolog B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037337">
        <property type="entry name" value="Dip2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010506">
        <property type="entry name" value="DMAP1-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22754">
        <property type="entry name" value="DISCO-INTERACTING PROTEIN 2 DIP2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22754:SF34">
        <property type="entry name" value="DISCO-INTERACTING PROTEIN 2 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23024">
        <property type="entry name" value="AMP-dom_DIP2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06464">
        <property type="entry name" value="DMAP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01137">
        <property type="entry name" value="DMAP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51912">
        <property type="entry name" value="DMAP1_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1158"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="domain" description="DMAP1-binding" evidence="7">
        <location>
            <begin position="9"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="62"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="110"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="171"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="126"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="173"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005014926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1547" mass="168926" checksum="AD019D5F61994C9D" modified="2022-01-19" version="1">GDLEDHPVQPSALPTVAGFHPCERELEAWCDITQKGYEKKRAKLLARYIPLIQGVDPSLQAENRVPGTSQATAVVSKQQKSHSTNSRDERFRSDVHTEAVQAALAKYKERKMPMPSKRRSVLVHSSVETYTPPDTSSASEDEGSLRRQGRITSTPFQSHSNAEPWLNRVIQGSSTSSSASSTSSHPGGKPAAASSTATATTAATVLADLMAHIQLDNHSAPPDVTTGLVEQLHHEQPQVASVRGVPRGYNSSILETGDGVPVNSRVSSKIQQLLNTLKRPKRPPLKEFFVDDFEELLEVQQPDPNQPKPEGNQMNVLKGEPVSVVTNWPPSLLAALQRWGTTQPKAPCLTALDTTGKAVYTLTYGKLWSRSLKLAYTLLNKLTSRNEPLLKPGDRVALVFPNSDPVMFMVAFYGCLLAELIPVPIEVPLTRKDAGSQQVGFLLGSCGVTLALTTDACQKGLPKAQTGEVVTFKGWPRLIWFVIDGKHLAKPTKDWHPQLRDASAEIAYIEYKTSKEGSTVGITISHASMLAHCHALTQACGYSEAETLTNVLDFKRDAGLWHGVLTSVMNRMHVISIPYALMKVNPLSWIQKVCSYKARVAVVKSRDMHWSLLAQRDQRDVSLSSLRMLIVADGANPWSISSCDAFLNVFQSRGLRPEVICPCASSSEALTVAIRRPPELGGPPPGKAVLSMNCLSYGVIRVDTEEKLSVLTVQDVGQIMPGANVCVVKVDGTPYLCKADEVGEICVNSGATGMAYFGLVGITKNVFEAIPVTATGVPVSDQPFTRTGLLGFVGPDYLVFVVGKLDGLITVSGRRHNADDVVATALAVEPMKFVYRGRIAVFSVTVLHDDRIVLVAEQRPDASEEDSFQWMSRVLQAIDSIHQVGVYCLALVPANTLPKAPLGGIHISETKQRFLEGALHPCNVLMCPHTCVTNLPKPRQKQPDVGPASMIVGNLVAGKRIAQASGRDVTQLEDNDQARKFLYLADVLQWRAQTTPDHPLFLLLNSKGTVASTASCMQLHKRAERVAVALMEKGRLNVGDHVALVYPPGVDLIATFYGCLYAGCIPVTVRPPHAQSLTATLPTVRMIVEVSKSACILTTQVITKLLKSKEAAAAVDIKTWPTILDTDDMPKKKLANIFRPTSPDMLAYLDFSVSTTGILMAVLISLNIGIFAFIFPTYFKICTTSFVYSGHQSILVPPLELESNVSLWLSAVSQYKVRVTFCSYSVMEMCTKGLGTQTDMLRMKGVNLSCVRTCMVVAEERPRIALTQSFSKLFKDLGLSARAVSTTFGCRVNVAICLQGTAGPDPTTVYVDMRALRHDRVRLVERGSPHSLPLMESGKILPGVKVIIAHTETKGPLGDSHLGEIWVSSPHNATGYYTVYGEEALHADHFTARLSFGDTQTIWARTGYLGFLRRTELTDASGERHDALYVVGSLDETLELRGMRYHPIDIETSVIRAHKSIAECAVFTWTNLLVVVVELEGSEQEALDLVALVTNVVLEEHYLIVGVVVIVDPGVIPINSRGEKQRMHLRDGFLADQLDPIYVAYNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TTB7</accession>
    <name>A0A8C2TTB7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3-hydroxyisobutyryl-CoA hydrolase</fullName>
            <shortName evidence="9">HIB-CoA hydrolase</shortName>
            <shortName evidence="9">HIBYL-CoA-H</shortName>
            <ecNumber evidence="9">3.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">3-hydroxyisobutyryl-coenzyme A hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">HIBCH</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-methylpropanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20888"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57340"/>
            <dbReference type="EC" id="3.1.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Amino-acid degradation; L-valine degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.4" evidence="9"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2TTB7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005023513.1">
        <property type="protein sequence ID" value="ENSCJPP00005016791.1"/>
        <property type="gene ID" value="ENSCJPG00005013772.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00890000139491"/>
    <dbReference type="UniPathway" id="UPA00362"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003860">
        <property type="term" value="F:3-hydroxyisobutyryl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000026">
        <property type="entry name" value="3-hydroxyisobutyryl-CoA hydrolase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045004">
        <property type="entry name" value="ECH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032259">
        <property type="entry name" value="HIBYL-CoA-H"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004127">
        <property type="entry name" value="PRK05617.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176:SF3">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16113">
        <property type="entry name" value="ECH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0101">Branched-chain amino acid catabolism</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl-CoA hydratase/isomerase" evidence="10">
        <location>
            <begin position="46"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU369070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005016791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="385" mass="43038" checksum="BA490F94BE842D0F" modified="2022-01-19" version="1">MAARVMMAPLRYQSRSLYLVFLHLQKTFKHTDSTADVLLQKKGGAGIITLNRPKVLNALSLRMIQQIYPQLKAWEQDPETFLIIIKGTGEKAFCAGGDVRAIADAIKAGDRMTQDYFREEYTLNNAVGTCKKPYVALIDGITMGGGVGLSVHGHFRVATEKTVFAMPETAIGLFPDVGGGYFLPRLPGKIGYLLALTGFRLKGRDVLKAGIATHFVQSDKLPDLEKDLIALKSPSKENIAELLNSYHKQTKIDQEKEFVLDEHMEKINSIFSANRMEDIVQKLKQDGSPFAMKQLETINKMSPTSLKLTLRQLREGASLSLQEVFTMEYRLSQACMRGHDFYEGVRAVLIDKDQSPRWKPAALEEVSDEFVDSCFKPLGNSDLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TU20</accession>
    <name>A0A8C2TU20_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 4E binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">EIF4EBP1</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF4E-binding protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015738661.1">
        <property type="nucleotide sequence ID" value="XM_015883175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TU20"/>
    <dbReference type="SMR" id="A0A8C2TU20"/>
    <dbReference type="Ensembl" id="ENSCJPT00005025943.1">
        <property type="protein sequence ID" value="ENSCJPP00005018679.1"/>
        <property type="gene ID" value="ENSCJPG00005015195.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107323781"/>
    <dbReference type="KEGG" id="cjo:107323781"/>
    <dbReference type="CTD" id="1978"/>
    <dbReference type="GeneTree" id="ENSGT00940000159932"/>
    <dbReference type="OrthoDB" id="19729at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008190">
        <property type="term" value="F:eukaryotic initiation factor 4E binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030371">
        <property type="term" value="F:translation repressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071549">
        <property type="term" value="P:cellular response to dexamethasone stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008286">
        <property type="term" value="P:insulin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002192">
        <property type="term" value="P:IRES-dependent translational initiation of linear mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045947">
        <property type="term" value="P:negative regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045931">
        <property type="term" value="P:positive regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008606">
        <property type="entry name" value="EIF4EBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12669">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12669:SF14">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05456">
        <property type="entry name" value="eIF_4EBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0652">Protein synthesis inhibitor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0810">Translation regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="22"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005018679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="116" mass="12500" checksum="88DC636C77EF0619" modified="2022-01-19" version="1">MSGRCCQGQTPSRDIPGPGKRLALPDGAPLPPGDYSTTPGGTVFGTTPGGTRIIYDRKFLMECRNSPVAKTPPSDLPDIPGVTSPIVEELKIENNHVQNYDEKANVGEEEQFDMDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TVQ3</accession>
    <name>A0A8C2TVQ3_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Class II histocompatibility antigen, B-L beta chain-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC107321546</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TVQ3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005026874.1">
        <property type="protein sequence ID" value="ENSCJPP00005019400.1"/>
        <property type="gene ID" value="ENSCJPG00005015710.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183127"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042613">
        <property type="term" value="C:MHC class II protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002504">
        <property type="term" value="P:antigen processing and presentation of peptide or polysaccharide antigen via MHC class II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05766">
        <property type="entry name" value="IgC1_MHC_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.320.10:FF:000001">
        <property type="entry name" value="HLA class II histocompatibility antigen, DRB1-1 beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.320.10">
        <property type="entry name" value="Class II Histocompatibility Antigen, M Beta Chain, Chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003006">
        <property type="entry name" value="Ig/MHC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003597">
        <property type="entry name" value="Ig_C1-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050160">
        <property type="entry name" value="MHC/Immunoglobulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011162">
        <property type="entry name" value="MHC_I/II-like_Ag-recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014745">
        <property type="entry name" value="MHC_II_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000353">
        <property type="entry name" value="MHC_II_b_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19944:SF99">
        <property type="entry name" value="HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DRB1 BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19944">
        <property type="entry name" value="MHC CLASS II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07654">
        <property type="entry name" value="C1-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00969">
        <property type="entry name" value="MHC_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00407">
        <property type="entry name" value="IGc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00921">
        <property type="entry name" value="MHC_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54452">
        <property type="entry name" value="MHC antigen-recognition domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00290">
        <property type="entry name" value="IG_MHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0391">Immunity</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0491">MHC II</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="336"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="200"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="25"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005019400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="428" mass="46974" checksum="6748ADFC12580906" modified="2022-01-19" version="1">MTVVISWGTIGWDEGRWDPRVAMGEGKSVRQSPAAPSSAWRRVTPPRPAAPHWPSPPGPGLGAGVGCRVPHRRAAAAMGSGRVPAAVAVLVALLALGARSAYGTRPSAYFQHSFISECHFLNGTQRVRLVDRYIYNRQQYVHFDSDVGKFVADTALGERQAEYWNSQTEILEDARGAVDTYCRYNYGVDEPFTVQRSVQPKVRVSALQSGSLGESDRLACYVTGFYPPEIEVKWFQNGREETERVVSTDVMQNGDWTYQVLVVLETVPRRGDSYECRVEHASLPQGISQPWEPPSDAGRSKMLTGVGGFVLGLVFLALGLFMFLRSQKGQPVATTPGNIPFLFLFLFLSPSWAQLCPSPRRDAELAAAPPSRSTGTPGCRPGSPSGCHRVPSSCHRDAFFCPHPIKRAAFFCPHPIKRADLEAAVRCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TW63</accession>
    <name>A0A8C2TW63_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TW63"/>
    <dbReference type="Ensembl" id="ENSCJPT00005024920.1">
        <property type="protein sequence ID" value="ENSCJPP00005017931.1"/>
        <property type="gene ID" value="ENSCJPG00005014567.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000007971"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007129">
        <property type="term" value="P:homologous chromosome pairing at meiosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070197">
        <property type="term" value="P:meiotic attachment of telomere to nuclear envelope"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027816">
        <property type="entry name" value="MAJIN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35824:SF1">
        <property type="entry name" value="MEMBRANE-ANCHORED JUNCTION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35824">
        <property type="entry name" value="MEMBRANE-ANCHORED JUNCTION PROTEIN MAJIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15077">
        <property type="entry name" value="MAJIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005017931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="191" mass="22160" checksum="B1D2A7D96B2542EF" modified="2022-01-19" version="1">MPLKPFAYPLPETRFLHAGGIVYKFKIRYGNFIIPSLFWFFQEAIRVILGNLDDLHPFSTDHFTIFPYLSKWERVSEMRFEHKNVDLVPYPYICTMYLELNSFQQSLSLGKSAWLCLGHFLNKEVFFSSFSVSVHCVLWVPHPCSHSRPHIRYRAPSTARLLPDSTPPSRASRGSSFTPIQGILKTLFIQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TWK4</accession>
    <name>A0A8C2TWK4_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Rhophilin-2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">GTP-Rho-binding protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">RHPN2</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RHPN family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TWK4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005024708.1">
        <property type="protein sequence ID" value="ENSCJPP00005017736.1"/>
        <property type="gene ID" value="ENSCJPG00005014446.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153837"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003094">
        <property type="term" value="P:glomerular filtration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051497">
        <property type="term" value="P:negative regulation of stress fiber assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09249">
        <property type="entry name" value="BRO1_Rhophilin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11634">
        <property type="entry name" value="HR1_Rhophilin-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06712">
        <property type="entry name" value="PDZ_rhophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.160:FF:000007">
        <property type="entry name" value="Rhophilin-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.280:FF:000003">
        <property type="entry name" value="RHPN1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000160">
        <property type="entry name" value="RHPN1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.160">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011072">
        <property type="entry name" value="HR1_rho-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036274">
        <property type="entry name" value="HR1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049603">
        <property type="entry name" value="Rhophilin-2_HR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047138">
        <property type="entry name" value="RHPN1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047902">
        <property type="entry name" value="RHPN2_BRO1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23031">
        <property type="entry name" value="RHOPHILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Hr1"/>
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    <keyword evidence="5 8" id="KW-0175">Coiled coil</keyword>
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        <source>
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    </evidence>
    <sequence length="713" mass="80106" checksum="CB7ECF1B1EF6F400" modified="2022-01-19" version="1">MMDAVPARGCPQEDCYFRKGCNPLAETGRSKLQNQRAVLNQQILRAVRMRAGAENLLRATTNNKVREQVLLELSFVNSDLQILKEELEGLNISVEVYQNTEETFSIPLVPLGLKETKEVDFTLPLKDFILEHYSEDSSEYEDEIADLMDLRQACRTPSRDEAGIEMLMSYFLQLGFIENRFFPPTRHMGVLFTWYDSFTGVPVCQQNLLLEKASILFNIGALYTQIGTRCNRQTQTGLENAVDAFQRAAGVLNYLKETFTHTPSYDMSPAMLNVLVKMMLAQAQECAFEQLSLPGIRNEFFTLVKMTQEVAKVGEVYMMVNTAVTQEPVKENIPYSWSKLVQIKADHYRALAHYFLATILCDHEMQSSDDEDQQEKALSQLYDYVPEGVMILTILKDKVQRKQLGKAHLRKAIVYHEEALRVCGLCKKLRNIEVLLEVLTAAHKRSLLKYAQQETEDDFLSLIQAPDILPKTEHKVEMVPPQFSKLKVKDFFHRLGPLSVFSAKQRWTAPRTIRCHWETGELGFSLKGGSPVQIHCLDPACSAASAGLKEGDYIVSVGGVDCKWLGVNEVLEKFRSVGKQPIEFEVISCQDTTASMHSKSATYSVGMQKTYSLICLAMDENKTDQAKKAPLKLPFLSWGTKNRQKAASTLCLPSAVAGSSQVKKKLSPFTLLGFCNTPLKESISIPEDSQLHGSMATCVLGVKSSVHSNISNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TX55</accession>
    <name>A0A8C2TX55_COTJA</name>
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        <submittedName>
            <fullName evidence="11">Transmembrane p24 trafficking protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">TMED6</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
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        <subcellularLocation>
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        </subcellularLocation>
    </comment>
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        <text evidence="2 8">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TX55"/>
    <dbReference type="Ensembl" id="ENSCJPT00005025990.1">
        <property type="protein sequence ID" value="ENSCJPP00005018725.1"/>
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    </dbReference>
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        <property type="component" value="Chromosome 11"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
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        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
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            <begin position="24"/>
            <end position="240"/>
        </location>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU003827"/>
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    </evidence>
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            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005018725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="240" mass="27236" checksum="D9C0426D945736FB" modified="2022-01-19" version="1">MCTGSSMLLLVLLVLGLPGPAACPRTEPLSGTSSEPLFRGADRYDFAVVVHAGTSECFWQFAHQSGNFFFSFEVQRATGMANSRNILATATDPNGFQLGASQDVRGQINFLTKETGFYQLCLDNGQNHFGFVQVYLNFGVYYDGFNMEKEQVKERKQLNDTLDAIGDSIQKLQIHIFHMWRFYNFARMRKGADYFLLESNYHYVNWWSMAQSCVIVLSGVLQLYFLKRLFNVQSSGKPTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TY75</accession>
    <name>A0A8C2TY75_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pecanex-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">PCNX1</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the pecanex family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSCJPT00005025614.1">
        <property type="protein sequence ID" value="ENSCJPP00005018384.1"/>
        <property type="gene ID" value="ENSCJPG00005014974.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157417"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039797">
        <property type="entry name" value="Pecanex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007735">
        <property type="entry name" value="Pecanex_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12372">
        <property type="entry name" value="PECANEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12372:SF2">
        <property type="entry name" value="PECANEX-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05041">
        <property type="entry name" value="Pecanex_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1162"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1228"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1267"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1319"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="1353"/>
            <end position="1371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1450"/>
            <end position="1470"/>
        </location>
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        <location>
            <begin position="1941"/>
            <end position="2167"/>
        </location>
    </feature>
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    </feature>
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            <begin position="2225"/>
            <end position="2294"/>
        </location>
    </feature>
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        <location>
            <begin position="2352"/>
            <end position="2373"/>
        </location>
    </feature>
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            <begin position="50"/>
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    </feature>
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            <end position="917"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="971"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="2225"/>
            <end position="2235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="2255"/>
            <end position="2265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="2272"/>
            <end position="2291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005018384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="2514" mass="275894" checksum="16FC2718B4C9CDFF" modified="2022-01-19" version="1">MSRTGAEPERNPVFHRAQAVRPAAGPCGWGSCPADGGNGRGVALLPPLGGAAPTPLGMKAAGSPRAGAVPAAPAPAASSLPGDRERGRRPLPQGLPVYRRRGGGRPARGPDIRWRRRCWGGGGGDGCGCGRAGCRGARAVRGSARAPRADRAGPARRSGAAMGSQVLQILRQGVWAALSGGWYQDPHQGAGVNALHLYLWLFLLGFPFTLYMALPSSMMIVAVYCPVIAALFIVLKMVNYRLHRALDEGEIVERNANERMNRGAKTEQSSVSAKRKDSNGPSDPGGGIEMSEFIREATPPVGCSSRNSYAGIDPNNQVGSGLSRLGTAATIKGDTDTAKTSDDISLSLGQSSSLCKEGSEEQDLATDRKLFRLVSNDSFVSIQPSLSSGQDLPRDNSDKVCLSNNQLVDQSKASACDTEVASLITLHSHSYRKDHRPRGVPRTSSSAVAFPDASLNDFPLYQQRRGLDTVSELEASKPPSASRESLAENSCISGVFQLDDILKSSSPQPLAKSGKSKSLKADKSVDSLRSLSTRSSGSTESYCSGTDRDTNSTISSYKSEHTSSTHIESVLSEHEEESPREEKKDGKKKDCGVDSEDDSSSTTDKRTSSERTAVEVSSISGVQEVKGSNASNEMLGQKGLSASASEEANKNPHANELTTQADRPPGKAAEQRDEQSEKLVLLVDSRASKETSGKQKEGDVRPKSSSLIHRTASTHKSSRRRTGKKRASSFDSSRHREYVSFRSVSGTKPHSAVFCHDEDSSDQSDLSRTSSMQSAHQFSSDSSSSTTSHSCQSPDGKYSALKTKYVSKDRGGTDSENIHKAHVSSEGISKKRSTRRTSSTNSAKNRARVLSLDSGTVACLNDPNSLMTPGNIKQLTTSKSDLEAKEGEVLDELSLLGRASHLESVTRSRNSLPSQATFPEGEEQESASGAAQASEETVTFRRERSTFRRQAVRRRHNAGSNPTPPTLLIGSPLSLQDGQQGQQSSSQAKVQSRSPSQAAVLSASTSLLVRNGSVHLEASHATASAVGGSSLHDGLGKFSSTLYETGGCDMSLVNFEPAARRASNICDTDSHVSSSTSVHFYPHDLLSLPQIRLNRLLTIDTDLLEQQDIDLSPDLQDHLQPQEEAAQKVKQYYRFWILPKLWISINFDRLTLLALFDRNREILENVLAVILAILVAFLGSVLLIEGFFKDIWVFQFCLVIASCQYSLLKSVQPDSSSPRHGHNRIIAYSRPVYFCLCCGLIWLLDYGSRNISTTRFKLYGMAFTNPLLLLSARDLVIVFTLCFPIVFFIGLLPQVNTFVMYLCEQLDIHVFGGNATTSLLAALYSFICSIVAVALLYGLCYGALKDSWDGQHIPVLFSIFCGLLVAMSYHLSRQSSDPSVLFSLVQSKFFPNSEDKNPEDPLSEVKDPLPEKLRNSVSERLQSDLIVCIVIGVLYFAIHVSTVFTVLQPILSYVLYALVGTVGFVTHYVLPQLRKQLPWHCFSHPLLKTKEYYQFEVRNAAHVMWFEKLHIWLLFIEKNVIYPLIVLNELSSSAKSIASPKKLDTELGALMITIAGLKLLRSSFSSPTCQYVTVIFTVLFFTFDYKSFTETMLLDLFFMSILFSKLWELFYKLRFVYTYIAPWQITWGSAFHAFAQPFAVPHSAMLFVQAAVSAFFSTPLNPFLGSAIFITSYARPVKFWERDYNTKRVDHSNTRLASQLDRNPGSDDNNLNSIFYEHLTRSLQHSLCGDLLLGRWGNYSTGDCFILASDYLNALVHLIEIGNGLVTFQLRGLEFRGTYCQQREVEAITEGVEEDEGFCCCEPGHLPHMLSFNAAFGQRWLAWEVLVTKYVLEGYSITDNSAASMLQVFDLRKILTTYYVKGIIYYVTTSPKLEEWLANETMQEGLRLCTDRNYVDVDPTFNPNIDEDYDHRLAGISRESFCMIYLNWIEYCCSRREKPLDSSKDSPLVTLCYGLCVLGRRALGTASHHMSSNLESFLYGLHALFKGDFRISSIRDEWIFADMELLRKVVVPGIRMSLKLHQDHFTSPDEYDDPSVLYEAITTHEENLVIAHEGDPAWRSAVLSNSPSLLALRHVMDDGTNEYKIIMLNKRYLSFRVIKVNKECVRGLWAGQQQELVFLRNRNPERGSIQNAKQALRNMINSSCDQPIGYPIYVSPLTTSYSDSHEQLKEILGGAISLGNIRNFIVSTWHRLRKGCGAGCNSGGNIEDSDAGGGASCTSNNATINESQSSVSQGGVNAPTGQGPGAVQHPPMAPHPGTHPTALPAAHPPTHPSTLGTSHSSHSVQSSLVRHSPARASVASHSSYCYGSRHSSLRTSTTGFVPCRRSSTSQISLRNLPSSIQSRLSMVNQMEPTGQSGVSMQHGLPSSSSSSQSIPACKQHALVGFLGTEGGSNAAETQSAGNASPANQMQAKKDDVIYRIQLMDPSQVLEGINVSKRKELQWPDEVIRLKAGRNSWKDWSPQEGMEGHVIHRWVPCSRDPSSRSHIDKTILLVQIEDKYVAVVETGVLELGAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TYE7</accession>
    <name>A0A8C2TYE7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">TNF receptor-associated factor</fullName>
            <ecNumber evidence="19">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">TRAF2</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 19">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TNF receptor-associated factor family. A subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="19"/>
    <dbReference type="RefSeq" id="XP_015734184.1">
        <property type="nucleotide sequence ID" value="XM_015878698.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TYE7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005027012.1">
        <property type="protein sequence ID" value="ENSCJPP00005019509.1"/>
        <property type="gene ID" value="ENSCJPG00005015808.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107321623"/>
    <dbReference type="CTD" id="7186"/>
    <dbReference type="GeneTree" id="ENSGT00940000156621"/>
    <dbReference type="OrthoDB" id="6499288at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035631">
        <property type="term" value="C:CD40 receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990604">
        <property type="term" value="C:IRE1-TRAF2-ASK1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097057">
        <property type="term" value="C:TRAF2-GSTP1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002947">
        <property type="term" value="C:tumor necrosis factor receptor superfamily complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005174">
        <property type="term" value="F:CD40 receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019903">
        <property type="term" value="F:protein phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046625">
        <property type="term" value="F:sphingolipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031996">
        <property type="term" value="F:thioesterase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043120">
        <property type="term" value="F:tumor necrosis factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005164">
        <property type="term" value="F:tumor necrosis factor receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007249">
        <property type="term" value="P:canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160162">
        <property type="term" value="P:CD27 signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023035">
        <property type="term" value="P:CD40 signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071732">
        <property type="term" value="P:cellular response to nitric oxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097400">
        <property type="term" value="P:interleukin-17-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048255">
        <property type="term" value="P:mRNA stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043124">
        <property type="term" value="P:negative regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038061">
        <property type="term" value="P:non-canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043123">
        <property type="term" value="P:positive regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001238">
        <property type="term" value="P:positive regulation of extrinsic apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032743">
        <property type="term" value="P:positive regulation of interleukin-2 production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002726">
        <property type="term" value="P:positive regulation of T cell cytokine production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903265">
        <property type="term" value="P:positive regulation of tumor necrosis factor-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097300">
        <property type="term" value="P:programmed necrotic cell death"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051865">
        <property type="term" value="P:protein autoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070534">
        <property type="term" value="P:protein K63-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002637">
        <property type="term" value="P:regulation of immunoglobulin production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046328">
        <property type="term" value="P:regulation of JNK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043254">
        <property type="term" value="P:regulation of protein-containing complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023019">
        <property type="term" value="P:signal transduction involved in regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042110">
        <property type="term" value="P:T cell activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905669">
        <property type="term" value="P:TORC1 complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905670">
        <property type="term" value="P:TORC2 complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038203">
        <property type="term" value="P:TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033209">
        <property type="term" value="P:tumor necrosis factor-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd16639">
        <property type="entry name" value="RING-HC_TRAF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000035">
        <property type="entry name" value="TNF receptor-associated factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000189">
        <property type="entry name" value="TNF receptor-associated factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000369">
        <property type="entry name" value="TNF receptor-associated factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.210.10:FF:000035">
        <property type="entry name" value="TNF receptor-associated factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012227">
        <property type="entry name" value="TNF_rcpt-assoc_TRAF_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049342">
        <property type="entry name" value="TRAF1-6_MATH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027133">
        <property type="entry name" value="TRAF2_RING-HC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049441">
        <property type="entry name" value="TRAF2_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032070">
        <property type="entry name" value="TRAF_BIRC3-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001293">
        <property type="entry name" value="Znf_TRAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131">
        <property type="entry name" value="TNF RECEPTOR ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131:SF21">
        <property type="entry name" value="TNF RECEPTOR-ASSOCIATED FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21355">
        <property type="entry name" value="TRAF-mep_MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21341">
        <property type="entry name" value="TRAF2_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16673">
        <property type="entry name" value="TRAF_BIRC3_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02176">
        <property type="entry name" value="zf-TRAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015614">
        <property type="entry name" value="TRAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57953">
        <property type="entry name" value="Trimerization domain of TRAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50145">
        <property type="entry name" value="ZF_TRAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 19" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="18" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10 19 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="15" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="13" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="14 19 20" id="KW-0862">Zinc</keyword>
    <keyword evidence="12 20" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="21">
        <location>
            <begin position="34"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="TRAF-type" evidence="23">
        <location>
            <begin position="125"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="TRAF-type" evidence="23">
        <location>
            <begin position="177"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="MATH" evidence="22">
        <location>
            <begin position="377"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="TRAF-type" evidence="20">
        <location>
            <begin position="125"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="TRAF-type" evidence="20">
        <location>
            <begin position="177"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRNR" id="PIRNR015614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005019509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="527" mass="59244" checksum="6DFB5272A9864C89" modified="2022-01-19" version="1">MAAANSTPPGSLDLNQPGFAKEILGTKLEVKYLCSDCRNILRRPFQAQCGHRYCSYCLKKIISSGPQKCASCIQEGIYEEGVSILETSSAFPDNAARREVESLPAVCINEGCTWKGTIKEYESCHEGNCPFLLIECKACRGVIPLNEKQRHSERECPERTLNCKYCKSLFYFPDIKAHDEVCPKFPLTCDGCGKKKIPREKFQDHVKSCGKCKVPCRFEVVGCAEMVENEKLPEHESKCLAEHLYMLLSFVLSLKSGSGDLKHLPTLPSSQSSSPLLAANSLCPESELFKSLELLGRCDALEKKTVTFENIVCVLNREVERVSLTAEAYSRQHRLDQEQIETLSNKVRQLERSIGLKDLAMAEMEEKIRNMEASTYDGVFIWKITEFARKRQEAITGRSPAIFSPAFYTSKYGYKMCLRVYLNGDGTGRGTHLSLFFVVMKGPNDALLRWPFNQKVTLMLLDQNNREHIIDAFRPDVTSSSFQRPVTEMNIASGCPLFCPVSVMEAKNSYVRDDAIFIKAIVDLSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TZG0</accession>
    <name>A0A8C2TZG0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TZG0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005026232.1">
        <property type="protein sequence ID" value="ENSCJPP00005018924.1"/>
        <property type="gene ID" value="ENSCJPG00005015375.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154136"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33332">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01345">
        <property type="entry name" value="CERVTRCPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005018924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="403" mass="45818" checksum="C9F25131F9EA317A" modified="2022-01-19" version="1">MLDHIKNEHVIRDSQHGFTRGRSCLTNLVAFYDGVTALVDEGKATDVIYLDLSKAFDMVPHHILISKLEGGGFDGWTTRWISNWLKGRRQRVVVNGSMSRWRPVTSGVPQGSVLGPVLFNIFINDIDEGMECTLSKFADDTKLSGAVDTVEGTDAIQRDLDRLESWARVNLMRFNTAKCKVLHLGRKNPRHLYRLGGVVLESSSAEKDLGVLVDEKLNMSQQCALAARKANGILGSIRRGVVSRDREVIVPLYSALVRPHLEYCVQVWSPQYKKDMEILERVQRRATKMIRGLEHLPYEDRLRELGLFSLEKRRLRGDLIAAFQYLKGTYSQEGSKLFERADNSRTRGNGFKLKEGRFRLDVRGKFFTRRVVRSWNRLPSEVVDAPSLEVFKTRLDGALGNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U065</accession>
    <name>A0A8C2U065_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Magnesium transporter protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">MAGT1</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the OST3/OST6 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015715938.1">
        <property type="nucleotide sequence ID" value="XM_015860452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U065"/>
    <dbReference type="Ensembl" id="ENSCJPT00005029279.1">
        <property type="protein sequence ID" value="ENSCJPP00005021310.1"/>
        <property type="gene ID" value="ENSCJPG00005017059.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107312767"/>
    <dbReference type="KEGG" id="cjo:107312767"/>
    <dbReference type="CTD" id="84061"/>
    <dbReference type="GeneTree" id="ENSGT00390000012030"/>
    <dbReference type="OrthoDB" id="67566at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160227">
        <property type="term" value="C:oligosaccharyltransferase complex B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050890">
        <property type="term" value="P:cognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015693">
        <property type="term" value="P:magnesium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000009">
        <property type="entry name" value="Tumor suppressor candidate 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021149">
        <property type="entry name" value="OligosaccharylTrfase_OST3/OST6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12692">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12692:SF2">
        <property type="entry name" value="MAGNESIUM TRANSPORTER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04756">
        <property type="entry name" value="OST3_OST6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 18" id="KW-0732">Signal</keyword>
    <keyword evidence="8 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034606854" description="Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1" evidence="18">
        <location>
            <begin position="33"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005021310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="338" mass="37749" checksum="667B20BC288FFDA3" modified="2022-01-19" version="1">MGARRRQGAVMAAMPVLVLALLLACGGPPAAGQKRKEMVLSEKVSQLMEWTSKRSVIRMNGDKFRRLVKAPPRNYSVVVMFTALQPHRQCVVCKQADEEYQILANSWRYSSAFTNKIFFAMVDFDEGSDVFQMLNMNSAPTFINFPAKGKPKRGDTYELQVRGFAAEQLARWVADRTDVNIRVIRPPNYAGPLMLGLLLAVIGGLVYLRGSNLDFLYNKTGWAFAALCFVLAMTSGQMWNHIRGPPYAHKNPHTGQVSYIHGSSQAQFVAETHIVLLFNGGVTLGMVLLHEAATSDMDVGKRKIMCIAGIGLVVFFFSWLLSVFRSKYHGYPYSFLMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U0Q5</accession>
    <name>A0A8C2U0Q5_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Potassium voltage-gated channel subfamily H member 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">KCNH7</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2U0Q5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005026920.1">
        <property type="protein sequence ID" value="ENSCJPP00005019441.1"/>
        <property type="gene ID" value="ENSCJPG00005015749.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155518"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005242">
        <property type="term" value="F:inward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000020">
        <property type="entry name" value="Potassium channel, voltage-gated eag-related subfamily H, member 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000011">
        <property type="entry name" value="Potassium channel, voltage-gated eag-related subfamily H, member 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.260:FF:000001">
        <property type="entry name" value="Potassium voltage-gated channel subfamily H member 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000001">
        <property type="entry name" value="Potassium voltage-gated channel subfamily H member 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003938">
        <property type="entry name" value="K_chnl_volt-dep_EAG/ELK/ERG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003967">
        <property type="entry name" value="K_chnl_volt-dep_ERG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050818">
        <property type="entry name" value="KCNH_animal-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10217:SF466">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY H MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10217">
        <property type="entry name" value="VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01463">
        <property type="entry name" value="EAGCHANLFMLY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01470">
        <property type="entry name" value="ERGCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="416"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="553"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="646"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="17">
        <location>
            <begin position="750"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1156"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="1038"/>
            <end position="1065"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005019441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1206" mass="136120" checksum="8BD003F1B94976A8" modified="2022-01-19" version="1">MPVRRGHVAPQNTFLGTIIRKFEGQNKKFIIANARVQNCAIIYCNDGFCEMTGFSRPDVMQKPCTCDFLHGPETKRHHIAQIAQALLGSEERKVEVTYYHKNGSTFICNTHIIPVKNQEGVAMMFIINFEYVTDEENIASPEKCNPILPSKLVNHGNNLSSGSSSGKLFGFRLPGLRLLTYRKQSLPQEDPDAVIIDSSKHSDDSVAMKHFKSPTKESCSPSEVDDTKALIQPSTCSPLVNISGPLDHSSPKQQWDRLYPDTIQTSNPLTHSRSKESICSIRRASSVHDIEGFTVHPKNIFRDRHASEGPFNHIKSSLLGSTSDSNLNKYSTINKIPQLTLNFSDIKNEKKSSSPPSSEKAIIAPKVKDRTHNVTEKVTQVLSLGADVLPEYKLQTPRINKFTILHYSPFKAVWDWLILLLVIYTAIFTPYSAAFLLNDSEERKRRECGYSCSPLNVVDLIVDIMFIIDILINFRTTYVNQNEEVVSDPAKIAIHYFKGWFLIDMVAAIPFDLLIFGSGSEETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLMLLMCIFALIAHWLACIWYAIGNVERPYLAHKIGWLDSLGEQLGKHYNKSDASSGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHMQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWTYTNGIDMNMQVLKGFPECLQADICLHLNQNLLQNCKAFRGASKGCLRALAMKFKTTHAPPGDTLVHCGDVLTALYFVSRGSIEILKSDIVVAILGKNDIFGEMVHLYAKPGKSNADVRALTYCDLHKIQREDLLEVLDMYPEFSDLFLTNLELTFNLRDETAKSDIVIRSQTTNDTNGDNCKLRRRKLSFQSEIEKDYFKENDQSDPEPTGDNSRFYQSIKKHFEEKKSGSSSFVSSIEDEQKPLFSGIADYPSVTEKTTELDFEEMIHATEEILTDKRSDSCKDITDKRNWEEQNVREYQDSPSHSALPHVTWGICDTESDYVYGEVENRLDLLQEQLNRLESQMTADIQTILQLLQRQSTLIPPAYSMVTAGAEYQQPAIRFTQNLHPVASIKTDRSFSPSSQCPEFLDLEKSKLKSKESLSSGVHLNTASEDNLTSFLDQEREQSAECPPQHPKPYLPSIRHPSLPECSVSTVGILSLHRHVSDPGLPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U1G9</accession>
    <name>A0A8C2U1G9_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15 21">Inosine-5'-monophosphate dehydrogenase</fullName>
            <shortName evidence="15">IMP dehydrogenase</shortName>
            <shortName evidence="15">IMPD</shortName>
            <shortName evidence="15">IMPDH</shortName>
            <ecNumber evidence="15 21">1.1.1.205</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">IMPDH2</name>
        <name evidence="15" type="synonym">IMPDH</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15 21">
            <text>IMP + NAD(+) + H2O = XMP + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="1.1.1.205"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="15">Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12 15 21">Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15 20">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.205" evidence="15 21"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2U1G9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005028727.1">
        <property type="protein sequence ID" value="ENSCJPP00005020867.1"/>
        <property type="gene ID" value="ENSCJPG00005016642.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157726"/>
    <dbReference type="UniPathway" id="UPA00601">
        <property type="reaction ID" value="UER00295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097294">
        <property type="term" value="P:'de novo' XMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071353">
        <property type="term" value="P:cellular response to interleukin-4"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007623">
        <property type="term" value="P:circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006177">
        <property type="term" value="P:GMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046651">
        <property type="term" value="P:lymphocyte proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd04601">
        <property type="entry name" value="CBS_pair_IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000424">
        <property type="entry name" value="Inosine-5'-monophosphate dehydrogenase 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01964">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01302">
        <property type="entry name" value="IMP_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911:SF121">
        <property type="entry name" value="INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="INOSINE-5-MONOPHOSPHATE DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000130">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01240">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 19" id="KW-0129">CBS domain</keyword>
    <keyword evidence="2 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 15 21" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="3 15 21" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 15 17" id="KW-0520">NAD</keyword>
    <keyword evidence="11 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8 15 20" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 15 18" id="KW-0630">Potassium</keyword>
    <keyword evidence="6 15 21" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CBS" evidence="22">
        <location>
            <begin position="179"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="22">
        <location>
            <begin position="244"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimidate intermediate" evidence="15 16">
        <location>
            <position position="396"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15 16">
        <location>
            <position position="494"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15 17">
        <location>
            <begin position="339"/>
            <end position="341"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15 17">
        <location>
            <begin position="389"/>
            <end position="391"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15 18">
        <location>
            <position position="391"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15 18">
        <location>
            <position position="393"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="394"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15 18">
        <location>
            <position position="396"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="429"/>
            <end position="431"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="452"/>
            <end position="453"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="476"/>
            <end position="480"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="506"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="561"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU003927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU003928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005020867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="579" mass="62181" checksum="A372F2F3F2D0CC8E" modified="2022-01-19" version="1">QEGKLKPSELQPCAMATPPGVTARYVTARCVPCVQAALSLPCGRCRMIPAGRRRAACAGGAARGGMADYLISGGTGYVPDDGLTAQQLFSCGDGLTYNDFLILPGYIDFTADQVDLTSALTKRITLKTPLVSSPMDTVTEAGMAIAMALTGGIGFIHHNCTPEFQANEVRKVKKYEQGFITDPVVLSPNDRVRDVFEAKARHGFCGIPITDNGKMGGKLVGIISSRDIDFLKESEHDLPLGEIMTKREDLVVAPSGVMLKEANEILQRSKKGKLPIVNEDDELVAIIARTDLKKNRDYPLASKDSKKQLLCGAAIGTHEDDKYRLDLLVQAGVDAVVLDSSQGNSIFQINMIKYIKEKYPNLQVIGGNVVTAAQAKNLIDAGVDALRVGMGSGSICITQEVLACGRPQATAVYKVSEYARRFGVPVIADGGIQTVGHIAKALALGASTVMMGSLLAATTEAPGEYFFSDGIRLKKYRGMGSLDAMDKNLGSQNRYFSETDKIKVAQGVSGAVQDKGSIHKFIPYLIAGIQHSCQDIGAKSLTQVRAMMYSGELKFEKRTTSAQVEGGVHGLHSYEKRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U2V4</accession>
    <name>A0A8C2U2V4_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Connector enhancer of kinase suppressor of ras 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNKSR family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2U2V4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005029502.1">
        <property type="protein sequence ID" value="ENSCJPP00005021479.1"/>
        <property type="gene ID" value="ENSCJPG00005017187.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156709"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06748">
        <property type="entry name" value="PDZ_CNK1_2_3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09511">
        <property type="entry name" value="SAM_CNK1_2_3-suppressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000019">
        <property type="entry name" value="Connector enhancer of kinase suppressor of Ras 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000060">
        <property type="entry name" value="Connector enhancer of kinase suppressor of Ras 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049628">
        <property type="entry name" value="CNK1-3_SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051566">
        <property type="entry name" value="CNKSR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017874">
        <property type="entry name" value="CRIC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12844">
        <property type="entry name" value="CONNECTOR ENCHANCER OF KINASE SUPPRESSOR OF RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12844:SF21">
        <property type="entry name" value="CONNECTOR ENHANCER OF KINASE SUPPRESSOR OF RAS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10534">
        <property type="entry name" value="CRIC_ras_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51290">
        <property type="entry name" value="CRIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAM" evidence="3">
        <location>
            <begin position="21"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="CRIC" evidence="5">
        <location>
            <begin position="78"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="209"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005021479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="292" mass="32938" checksum="5D7381A4FFBE8294" modified="2022-01-19" version="1">NIVNFSLCFFHPVSAGLDDCLQQYIKNFEREKISGDQLLRITHQELEDLGVTRIGHQELILEAVDLLCALNYGLETENLRTLSHKLNASAKNLQNFITGRRRSGHYDGRTSRKLPNDFLTSVVDLIGAAKSLLAWLDRSPFAAVTDYSVTRNNVIQLCLELTTIVQQDCTVYETENKILHVCKTLSGVCDHIISLSSDPLVSQSAHLEVIQLTNIKPSEGLGMYIKSTYDGLHVITGTTENSPADRCKKIHAGDEVIQVNHQTVIWAWFFWIWLFHIIPRLLGFEGNSMKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U2Y6</accession>
    <name>A0A8C2U2Y6_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CTP synthase</fullName>
            <ecNumber evidence="10">6.3.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">UTP--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">CTPS2</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>UTP + L-glutamine + ATP + H2O = CTP + L-glutamate + ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the CTP synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="10"/>
    <dbReference type="RefSeq" id="XP_015741437.1">
        <property type="nucleotide sequence ID" value="XM_015885951.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U2Y6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005031054.1">
        <property type="protein sequence ID" value="ENSCJPP00005022665.1"/>
        <property type="gene ID" value="ENSCJPG00005017894.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107325262"/>
    <dbReference type="KEGG" id="cjo:107325262"/>
    <dbReference type="CTD" id="56474"/>
    <dbReference type="GeneTree" id="ENSGT00910000144179"/>
    <dbReference type="OrthoDB" id="1739076at2759"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097268">
        <property type="term" value="C:cytoophidium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019856">
        <property type="term" value="P:pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03113">
        <property type="entry name" value="CTPS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000207">
        <property type="entry name" value="CTP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000005">
        <property type="entry name" value="CTP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01227">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003792">
        <property type="entry name" value="PRK05380.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00337">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="CTP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550:SF2">
        <property type="entry name" value="CTP SYNTHASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTP synthase N-terminal" evidence="13">
        <location>
            <begin position="2"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase" evidence="12">
        <location>
            <begin position="310"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="562"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="575"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU810713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005022665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="586" mass="66095" checksum="39A9ABB298299599" modified="2022-01-19" version="1">MKYILVTGGVISGIGKGIIASSIGTILKSCGLRVTAIKIDPYINIDAGTFSPYEHGEVFVLNDGGEVDLDLGNYERFLDINLYKDNNITTGKIYQHVINKERHGDYLGKTVQVVPHITDAVQEWVMNQAKVPVDDDRKEPQICVIELGGTIGDIEGMPFVEAFRQFQFKAKRENFCNIHVSLVPQPNATGEQKTKPTQNSVRALRGLGLSPDLIVCRSAKPIEMAVKEKISMFCHVEPEQVIFIHDVSSTYRVPILLEEQGIIKYFKQRLNLPIDDQPSDLLMKWKKMADRYERLLKVCSIALVGKYTKLSDCYASVFKALEHSALAINHKLDLMYIDSTELERSTEAENSVKYHQAWHKLCKADGILVPGGFGIRGTEGKIQAISWARKQKKPFLGVCLGMQLAVVEFARNCLNWKDANSTEFDPDTKNPVVIDMPEHNPGDMGGTMRLGKRRTVFKTQNSILRKLYGDEMFVEERHRHRYEVNPELTHCFEEKGLKFVGHDTEGNRMEMIELENHPYFVGVQFHPEFSSRPMKPSPPYLGLLLAATGTLNAYLQRGCKLSPSESYSDLSDDSSPEKEFPKSETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U3V5</accession>
    <name>A0A8C2U3V5_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleolar and coiled-body phosphoprotein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">NOLC1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U3V5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005031589.1">
        <property type="protein sequence ID" value="ENSCJPP00005023061.1"/>
        <property type="gene ID" value="ENSCJPG00005018313.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00730000111092"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015030">
        <property type="term" value="C:Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001650">
        <property type="term" value="C:fibrillar center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014032">
        <property type="term" value="P:neural crest cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014029">
        <property type="term" value="P:neural crest formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007000">
        <property type="term" value="P:nucleolus organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039191">
        <property type="entry name" value="Nopp140-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007718">
        <property type="entry name" value="Srp40_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23216">
        <property type="entry name" value="NUCLEOLAR AND COILED-BODY PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23216:SF1">
        <property type="entry name" value="NUCLEOLAR AND COILED-BODY PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05022">
        <property type="entry name" value="SRP40_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Srp40 C-terminal" evidence="2">
        <location>
            <begin position="667"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="420"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="453"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="514"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="534"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="582"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="635"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="648"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005023061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="742" mass="78104" checksum="0140E342DFDA9CDD" modified="2022-01-19" version="1">MAPFPQRRRRRAPRKHARTHAQTYGRRYVMAAVRRRSGGTCRRSMAERRAVPSDLFPFVLAFLRENRFEGAARAFAKEAAAKEQDPNAASLLDIFSYWVRSPAARKRKLVPNGPQAKRTAATSSSESSSEEEEEEDAAPPAKKPAKATAVTKAKVLPAKKAKSSSEDSSDDSDSEEEEKKPAKKGTKPAAKPAVTKIQPQKKAESSSSDSSSSDEEEPKKQPPKAATPKAGNKAAQATTKVVNGKAPSSSSSSSSSEDSDEKKAAQKKAVPKKSVPKPVATQSCPGKTKPAKESSSSEDSSDSSDDEKPPAKKKPKSGQYSAVPPPQAVQTKKVLAKAPAKKADSSDSSDSSDEEEQMPPKGGTGKAAVAKTNVTPKNKAVTAKKAESSSDSDSDSSSEDEKKAGSKVPAKQPVIKNTSKPAKAAAKPGQAKKDSSSSSDSSDSDSSHKKTPVKPAAKTATPAAKKPQATAKKAQSSSDSDSSSSSSEEEKKKAPPTKLAGKTNKPVSKPTPAPKESSSDSESSSSEEEKKPAAKPVSKSTGAAKATVGKKAAASSSSSSSDSSSEEEEKPKNAGKGAQNNSHTAASTEKAKASTPAAKNQKPKPADDSSSSSESSSEEEKGKANGGIVKKKQKKDVQESETPDNKKAKNKPKTPHTVPKVKRAASPFRRVREEEIEVDARVADNSFDAKKGAAGDWGEKANNILKFTKGKSFRHEKTKKKRGSYCGGTISTQVNSIKFESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U6J3</accession>
    <name>A0A8C2U6J3_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat and fibronectin type-III domain-containing protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC107320959</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015732856.1">
        <property type="nucleotide sequence ID" value="XM_015877370.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005031867.1">
        <property type="protein sequence ID" value="ENSCJPP00005023224.1"/>
        <property type="gene ID" value="ENSCJPG00005018456.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107320959"/>
    <dbReference type="KEGG" id="cjo:107320959"/>
    <dbReference type="GeneTree" id="ENSGT00940000163984"/>
    <dbReference type="OrthoDB" id="2428204at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061172">
        <property type="term" value="P:regulation of establishment of bipolar cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17117">
        <property type="entry name" value="RA_ANKFN1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039269">
        <property type="entry name" value="ANKFN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21437:SF2">
        <property type="entry name" value="ANKYRIN REPEAT AND FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21437">
        <property type="entry name" value="WIDE AWAKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="444"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="2">
        <location>
            <begin position="1233"/>
            <end position="1336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1025"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1075"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1178"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1048"/>
            <end position="1060"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005023224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1349" mass="151244" checksum="F81E434EC838C68B" modified="2022-01-19" version="1">MASFGKLTEYFSLRKSRTELRSERRGRRSGSCCCSVTECRSLDRKLQRPLLGKSRTLPSIPQSPVLSRIPLLDSAVFQEAMPEQKSYQKHSAPDGQKGCTIPSAGDAWRLEDDGLDPPGDAPLQPQLRTAMEDAPFSHFRMRSFYMRKSLSVDNHLGSLGYTGHHAETKAERVRTRLRRQFSLGSADKKDFYQSKSESSLSRFAHRLSVKQKQEKRRKAEYGSAELSAFRPRSLSIEWSSSPKMTQQMRDLQLAQARKPPGPSSPNAAKRLYRNLSGKFRVNYTSFDEGSLVGRGEKEKPRKSYLFQSNAALFEAVELQDLDRVQELLKQYSPEELDLNTPNSEGLLPLDIAIMTNNAPIARALLQAGAKESPHFISLESRSLHLSTLVREAEQRVNELTAQVVNEAPSADCSEKEKQLKAWEWRYRLYKRMKAGFEHARVPDPPANVHLSVASSSSLQVTFCEPLSVNSAVVTKYKVEWSCSPSFSPLAGEAVVDKLKSLHYTIRGLTSGTAYYVQVSAYNMKGWGPPQASVPTFAIPSNWREYDGRAPRRRGQAEALDHLLGQVKTVHQHCICHEPCKSQPQSRKHSVSRSLKHLFHPGSKFLKTLKRGLYLTAIFYKDDNILVTHEDQIPVVEIDDTYSCLLMQDFLWFTKVSCMWDEILWLRQCVTVSQSSCSCILQTRFKMLLAISQMQGLLGIQDLGQVFFEPIKDKQGNILIVTLKEVKTNQTFESVRWVPICKLQTSRKSVSSPEEPTALDTLLISVQDKLAYHQRSSHALPPGLYLGYLKLCSAVDQIRVLVPEQLPNILCHVKIRSNPNISREEWEWLQKMASMEEPVPVESENETSPNHLFQELQVAIKELMALVNIPLQEAKDFRLYSQEVLDFGGQVSFLLLLPPSDDVCTAPGQNNPYTPQSGFLTLPLQIFELVHFFTYDREFITQYCQVSALLELESLLSQQSLREAFSDSELSTAKQRHQQVQEYIQQMEEIWREMRWMMDALQHARYKQPSCGLSLSGFLSTSGGTVKDKTRSSSSHLDFLPSPAPSPDSSRKLSSDLHGLSDEEGSSEVFLATDSDYDSSRAQSPKELDLVSSGPECCGRRAARSLRDSAPDVLQSHELQPAALASPEPRPPPELYDSDFVLPSRQIELLRVTEKRQAYCVRTSSLDFPKPLCPVARKSCPGSVDSSPTDSRAGAQGRPGTGSTHSPERGRTRSAEWTASFQEPAEQPGGKKPGSVTLRVCPQYETGLSKETSVKLHVTSQTSAGEVVKLVVLQMNDVSHGALGGSAAFCYGEEQLEHFGLVFASEEGERWLPDEARPLPLQAARPEGRFYVRIKETSPLVLQFGPATTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U732</accession>
    <name>A0A8C2U732_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tropomodulin 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TMOD3</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tropomodulin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2U732"/>
    <dbReference type="Ensembl" id="ENSCJPT00005032185.1">
        <property type="protein sequence ID" value="ENSCJPP00005023488.1"/>
        <property type="gene ID" value="ENSCJPG00005018619.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107318689"/>
    <dbReference type="KEGG" id="cjo:107318689"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="255" mass="28890" checksum="CD729A4C32E298D5" modified="2022-01-19" version="1">MELERIIRDTLTHFIQSHIPAADLSGMDDVFFSYITGVLEELGSPESSEETFDMDTFVEMMEAYIPGFAEIQSGNVCEMMFSLSERLGEARNKGELNLEVDKTYCSALSEDDDLKDGVELLLEMFPACTVSQAEKALAMALGNLEEAVQLIVEEKVEIGTAGASVKELVRPRRAPNHEELKQVILQKYMMVDSAEDQKTHRPAPPKEAPKKLIRYIDNQVVSTKGERYKDIKKPESEEMKKTYISLKPARKYKFH</sequence>
</entry>
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    <accession>A0A8C2U9T5</accession>
    <name>A0A8C2U9T5_COTJA</name>
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        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Coturnix japonica</name>
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                <person name="Warren W."/>
                <person name="Burt D.W."/>
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                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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    <dbReference type="AlphaFoldDB" id="A0A8C2U9T5"/>
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        <property type="component" value="Chromosome 1"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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        <location>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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    <feature type="transmembrane region" description="Helical" evidence="9">
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            <end position="297"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="338" mass="38631" checksum="EAFEAE0D33F89F20" modified="2022-01-19" version="1">MASGHTDNVTALSDPSTSCKDENFLQVKSYLSAFYGLIFLVCFPGNIVTIFVYFVKMRPWKGSTIIMLNLAVTDLLYVATLPFFIHYSANGNNWIFGNFMCKFIHFGFYFNMYSGIIFLSCFSIFRFLVVVHPVRCFFIQKKRWAVVTCTVIWLISLVTISPLNTLISIKHTQNRTICLDLSSAEDLDSTLWYNWLLTIFAFFLPLVTVTLCYALIIHALATGPHTQACYKQKARRLAVVLLVVFYVCFLPFHVFQMIRIELRVRVASCNLKNTILFIFILTKPLAALNTFGNLLLYVVAGDSFQHAFIILINQILVSLQSKKSKYVSDLIITCSFTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UAP0</accession>
    <name>A0A8C2UAP0_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="22">Gamma-aminobutyric acid type A receptor subunit beta3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">GABRB3</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Postsynaptic cell membrane</location>
            <topology evidence="17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2UAP0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005034094.1">
        <property type="protein sequence ID" value="ENSCJPP00005025036.1"/>
        <property type="gene ID" value="ENSCJPG00005019691.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154713"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043197">
        <property type="term" value="C:dendritic spine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902711">
        <property type="term" value="C:GABA-A receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098982">
        <property type="term" value="C:GABA-ergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004890">
        <property type="term" value="F:GABA-A receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022851">
        <property type="term" value="F:GABA-gated chloride ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904315">
        <property type="term" value="F:transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071420">
        <property type="term" value="P:cellular response to histamine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071294">
        <property type="term" value="P:cellular response to zinc ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021549">
        <property type="term" value="P:cerebellum development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042747">
        <property type="term" value="P:circadian sleep/wake cycle, REM sleep"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090102">
        <property type="term" value="P:cochlea development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035640">
        <property type="term" value="P:exploration behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007214">
        <property type="term" value="P:gamma-aminobutyric acid signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060022">
        <property type="term" value="P:hard palate development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060080">
        <property type="term" value="P:inhibitory postsynaptic potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904862">
        <property type="term" value="P:inhibitory synapse assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060119">
        <property type="term" value="P:inner ear receptor cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060384">
        <property type="term" value="P:innervation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007612">
        <property type="term" value="P:learning"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007613">
        <property type="term" value="P:memory"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061744">
        <property type="term" value="P:motor behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019098">
        <property type="term" value="P:reproductive behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072347">
        <property type="term" value="P:response to anesthetic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009410">
        <property type="term" value="P:response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035176">
        <property type="term" value="P:social behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051932">
        <property type="term" value="P:synaptic transmission, GABAergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd19053">
        <property type="entry name" value="LGIC_TM_GABAAR_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000004">
        <property type="entry name" value="Gamma-aminobutyric acid receptor subunit beta-2 isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000004">
        <property type="entry name" value="Gamma-aminobutyric acid receptor subunit beta-2 isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002289">
        <property type="entry name" value="GABAAb_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01160">
        <property type="entry name" value="GABAARBETA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0868">Chloride</keyword>
    <keyword evidence="11" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16 18" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 18" id="KW-0406">Ion transport</keyword>
    <keyword evidence="15" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 18" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 18" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034751976" evidence="18">
        <location>
            <begin position="26"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="266"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="451"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="20">
        <location>
            <begin position="39"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="21">
        <location>
            <begin position="244"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="396"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="403"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="418"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005025036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="470" mass="53811" checksum="EA1883684AD4CC89" modified="2022-01-19" version="1">MWGFGGGRIFGIFSAPVLVAVVCCAQSVNDPGNMSFVKETVDKLLKGYDIRLRPDFGGPPVCVGMRIEIASIDVDYTLTMYFQQYWRDKRLAYAGIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGGDNAVTGVERIELPQFSIVEYRLVSKNVVFATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGKGPQRQKKLAEKTAKANNDRSRFEGSRVDTHGNILLTSLEIHNEVASNEVTTSVTDARNSTISFDNSGIQYRKQSSHRESLGRRSSDRTGSHSKRGHLRRRSSQLKIKIPDLTDVNAIDRWSRMVFPFTFSLFNLIYWLYYVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UB01</accession>
    <name>A0A8C2UB01_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA exonuclease 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">REXO5</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UB01"/>
    <dbReference type="Ensembl" id="ENSCJPT00005032469.1">
        <property type="protein sequence ID" value="ENSCJPP00005023741.1"/>
        <property type="gene ID" value="ENSCJPG00005018774.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161162"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06145">
        <property type="entry name" value="REX1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:001454">
        <property type="entry name" value="RNA exonuclease 5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNA exonuclease 5 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034922">
        <property type="entry name" value="REX1-like_exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF82">
        <property type="entry name" value="RNA EXONUCLEASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="540"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="635"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="432"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="432"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005023741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="805" mass="89500" checksum="AEA540C49F68A12C" modified="2022-01-19" version="1">MSHLRRYEPPAVPSRPAAARSPRSVRMRRELGVSMAGPRGAVTGCKRRVGRSEEQPRGGKRNRAGTGQEKKSSHLSAALLGEDCEISLEQLSELLQYAALGRRHNAAQPSWCHIYHQSHLAGVVVIVLHELSQLHFYKFYLQFKHLRRVFRHRFTLPPPPSDFLASLCGEGAGPNPPGSAQGLISAGVECIPKSSGLDCDPIIRKYGKERRGLTSYTLTSEELKKNDYPMRDSPEYKGYMYTECDLQRTDSSPLFGLDCEMCLTARGNEVTRVSLVDAEGKCLLNELVKPESVIVNYRTRYSGITRKMLLPVKTRLPDIQTRLKKILPHDAVLVGHSLNADLQALQMIHPSVIDTSLLFARSEGRRFKLKFLAKAVLGKEIQCEQRLGHDPAEDARAALELAQFFIKKGPTKVAELNLEMLLAAERQTEISPNKSVKQPQQCGVQKQLNDPPHSSKPCILARLQGMGQKPLLLGRQELGSSGLCQSDLSTSNKQILQRALEDVPLSTFSIIQFGLNPEYFASHHLAGFCNKVRNKLTDMLTIYAGPFEESFCPKSVKKEFGKCGPIQSLTVVTETYQPYVCIQYDVLEAAQLALESLNGAEVAGSCIKVQRPITAATLDCDVLIKELEQDIENEGVIYVAGIKKSLTETDLQEEFSPLKDLETLFLPKDLQSGKHSTCCYLKFRNSHSAAEAMEAISGWAVRGSALRSRHALASGHLWRWIWKMNHSSEKQRGNNLSEKMAPRSDSEQDVRKEVKKLDHYIKKLYRSLQDNTLCVVLFPGTNSIHGSQSGLGLMGIKDDGESSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UC86</accession>
    <name>A0A8C2UC86_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transport and golgi organization 2 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">TANGO2</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015733106.1">
        <property type="nucleotide sequence ID" value="XM_015877620.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015733107.1">
        <property type="nucleotide sequence ID" value="XM_015877621.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UC86"/>
    <dbReference type="Ensembl" id="ENSCJPT00005033094.1">
        <property type="protein sequence ID" value="ENSCJPP00005024257.1"/>
        <property type="gene ID" value="ENSCJPG00005019153.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107321077"/>
    <dbReference type="KEGG" id="cjo:107321077"/>
    <dbReference type="CTD" id="128989"/>
    <dbReference type="GeneTree" id="ENSGT00390000012733"/>
    <dbReference type="OrthoDB" id="191601at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008551">
        <property type="entry name" value="TANGO2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17985">
        <property type="entry name" value="SER/THR-RICH PROTEIN T10 IN DGCR REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17985:SF8">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05742">
        <property type="entry name" value="TANGO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005024257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="276" mass="31058" checksum="F6AEEEADA98E9359" modified="2022-01-19" version="1">MCIILFKFDPRPVSKNAYRLILAANRDEFYSRPSKSADFWDSSNEILSGLDMEEGKEGGTWLGISKKGRMAALTNYMQPTTDKNAKGRGALVTNFLTSDLDCYSYLKKVSVEGHLYNGFNLLAADLNTIKGDVICYYGNKGGPEPVFLNPGIYGLSNCLLDTPWKKLQYGKQLFTEVINRSQDLAKEDLVQELLAVMNNQEPQLPDPAIEDQGKEYIRPILNKYAAVCVRCPGYGTRTNTVLLIDSEGNVTFTERTMINEDVSQWKTSTYEFKLHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UCM6</accession>
    <name>A0A8C2UCM6_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Zinc finger protein Pegasus</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Ikaros family zinc finger protein 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">IKZF5</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the Ikaros C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015723021.1">
        <property type="nucleotide sequence ID" value="XM_015867535.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015723023.1">
        <property type="nucleotide sequence ID" value="XM_015867537.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015723024.1">
        <property type="nucleotide sequence ID" value="XM_015867538.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UCM6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005034968.1">
        <property type="protein sequence ID" value="ENSCJPP00005025737.1"/>
        <property type="gene ID" value="ENSCJPG00005020170.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107316258"/>
    <dbReference type="KEGG" id="cjo:107316258"/>
    <dbReference type="CTD" id="64376"/>
    <dbReference type="GeneTree" id="ENSGT00940000155035"/>
    <dbReference type="OrthoDB" id="5576026at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000402">
        <property type="entry name" value="IKAROS family zinc finger 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000924">
        <property type="entry name" value="IKAROS family zinc finger 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001097">
        <property type="entry name" value="IKAROS family zinc finger 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24376:SF243">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24376">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="110"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="292"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="339"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00040442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005025737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="421" mass="46942" checksum="E9066B44542A3EB7" modified="2022-01-19" version="1">MGEKKPEPLDFVKDFQEYLTQQTHHVNMISGSVSGDKEAETLQGAGTEGDQNGLDHPSVEVSLDENSGMLVDGFERTFDGKLKCRYCNYASKGTARLIEHIRIHTGEKPHRCHLCPFASAYERHLEAHMRSHTGEKPYKCELCSFRCSDRSNLSHHRRRKHKMVPIKGTRSSLSSKKMWGVLQKKTSNLGYSRRALINLSPPSMVVHKPDYLNDFSHEIPNIQTEAYENMTKSSQSSGLPRDPQDLMVDNPLNQLSTLAGQLSSLPPENQNERGCSPDVVTCQDEKPFMMQQPATPAVVSSVSASIAQSSSPTSPDPRPAHNQRNYSPVAGPSSDRSAHTSTPSISNSQPSTPAPTLPVQDPQLLHHCQHCDMYFADNILYTIHMGCHGFENPFQCNICGCKCKNKYDFACHFARGQHSQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UCT7</accession>
    <name>A0A8C2UCT7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sterile alpha motif domain-containing protein 15</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UCT7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005033363.1">
        <property type="protein sequence ID" value="ENSCJPP00005024485.1"/>
        <property type="gene ID" value="ENSCJPG00005019287.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00630000089942"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46829">
        <property type="entry name" value="STERILE ALPHA MOTIF DOMAIN-CONTAINING PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46829:SF1">
        <property type="entry name" value="STERILE ALPHA MOTIF DOMAIN-CONTAINING PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005024485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="84" mass="9733" checksum="F2921535E1CC4A02" modified="2022-01-19" version="1">MFLSDIFVFQEISRHVRELLGFEEPVFSRSIALPYRDNMGLFLERKSRTGQKADALTFSQFVQEAGLEPYSTFPPVQQTQMGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UG38</accession>
    <name>A0A8C2UG38_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">N-sulfoglucosamine sulfohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">SGSH</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2UG38"/>
    <dbReference type="Ensembl" id="ENSCJPT00005036950.1">
        <property type="protein sequence ID" value="ENSCJPP00005027315.1"/>
        <property type="gene ID" value="ENSCJPG00005021194.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000013080"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043202">
        <property type="term" value="C:lysosomal lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016250">
        <property type="term" value="F:N-sulfoglucosamine sulfohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008340">
        <property type="term" value="P:determination of adult lifespan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006027">
        <property type="term" value="P:glycosaminoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030200">
        <property type="term" value="P:heparan sulfate proteoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061744">
        <property type="term" value="P:motor behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd16027">
        <property type="entry name" value="SGSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000026">
        <property type="entry name" value="N-sulphoglucosamine sulphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032506">
        <property type="entry name" value="SGSH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-SULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108:SF6">
        <property type="entry name" value="N-SULPHOGLUCOSAMINE SULPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16347">
        <property type="entry name" value="SGSH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Sulfatase N-terminal" evidence="7">
        <location>
            <begin position="68"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="N-sulphoglucosamine sulphohydrolase C-terminal" evidence="8">
        <location>
            <begin position="464"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005027315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="545" mass="61046" checksum="3D9E1D996FBEFF28" modified="2022-01-19" version="1">MASGTQTPATLHPAGGSSRAGSEPFRPAHVTGTEEELRPPSPSGTGSMRVWALPLLLGALRFGGAPARNVLLLLADDGGFESGAYNNSAIRTPNLDALARRSLLFQNAFTSVSSCSPSRASLLTGLPQHQNGMYGLHQGVHHFNSFDAVRSLPRLLHQANIRTGIIGKKHVGPEAVYPFDFAYTEENSSVLQVGRNITRIKALVRRFFQSQDVRPFFLYVAFHDPHRCGHSQPQYGAFCEKFGNGESGMGWIPDWKPQLYHPEDVQVPRFVPDTPSARADLAAQYTTIGRMDQGIGLVLEELRLAGVLNSTLVIYTSDNGIPFPGGRTNLYWSGTAEPLLLSSPEHPDLWGGSGAVPILYLTPTILDWFSIPYPSYSIFGTKEVQLTGKSLLPALQSEQPWATTFSSQSHHEATMYYPMRAIQHRQFRLIHNLNYKMPFPIDQDFYVSPTFQDLLNRTRAGQPTHWNKTLHQYYYRDRWELFDYSQDPTESHNLASDPHYADIFQMLRAQLLKWQWDTGDPWVCAPDAVLEEKLSPQCQPLHNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UH53</accession>
    <name>A0A8C2UH53_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Rabenosyn, RAB effector</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">RBSN</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
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        <scope>IDENTIFICATION</scope>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y609</accession>
    <name>A0A8C2Y609_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">U3 small nucleolar ribonucleoprotein protein IMP3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">U3 small nucleolar ribonucleoprotein protein imp3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">IMP3</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3. Component of a heterotrimeric complex containing IMP3, IMP4 and MPHOSPH10. Interacts with MPHOSPH10.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_015859934.2"/>
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        <property type="gene ID" value="ENSCJPG00005002767.1"/>
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        <property type="component" value="Chromosome 3"/>
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        <property type="term" value="C:cytosol"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="C:Mpp10 complex"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="U3 small nucleolar ribonucleoprotein IMP3"/>
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        <property type="entry name" value="Ribosomal_uS4"/>
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        <property type="entry name" value="Ribosomal_uS4_N"/>
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        <property type="entry name" value="S4_RNA-bd"/>
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        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 11" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS4 N-terminal" evidence="12">
        <location>
            <begin position="4"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00069727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00072223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
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    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01390"/>
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    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005002510.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="185" mass="21369" checksum="05EB805CCCA28463" modified="2022-01-19" version="1">MVRKLKYHEQKLLRRLELVSWEAAPGHVAELRALRRFRVGRREDYTRYRALARDIRALARRLRDLGPASAAFRSRSSALLLHKLYAMGIVGSRRSLAVCERVCAASFCRRRLPCVLLKLRMAQNMRHAVTFVEQGHVRVGPDLVTDPAVLVPRAMEDFVTWADASKLRVKVLDYNQERDDFDLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y7M6</accession>
    <name>A0A8C2Y7M6_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="33" type="primary">CSF1R</name>
    </gene>
    <organism evidence="33 34">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="33" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="33" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="33" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="27">Membrane</location>
            <topology evidence="27">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="27">Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y7M6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005009546.1">
        <property type="protein sequence ID" value="ENSCJPP00005005999.1"/>
        <property type="gene ID" value="ENSCJPG00005005658.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155506"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990682">
        <property type="term" value="C:CSF1-CSF1R complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019955">
        <property type="term" value="F:cytokine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019838">
        <property type="term" value="F:growth factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005011">
        <property type="term" value="F:macrophage colony-stimulating factor receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019903">
        <property type="term" value="F:protein phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045217">
        <property type="term" value="P:cell-cell junction maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021879">
        <property type="term" value="P:forebrain neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044794">
        <property type="term" value="P:host-mediated activation of viral process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061518">
        <property type="term" value="P:microglial cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021772">
        <property type="term" value="P:olfactory bulb development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030316">
        <property type="term" value="P:osteoclast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032722">
        <property type="term" value="P:positive regulation of chemokine production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070374">
        <property type="term" value="P:positive regulation of ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010759">
        <property type="term" value="P:positive regulation of macrophage chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120041">
        <property type="term" value="P:positive regulation of macrophage proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051897">
        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032956">
        <property type="term" value="P:regulation of actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002931">
        <property type="term" value="P:response to ischemia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031529">
        <property type="term" value="P:ruffle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001029">
        <property type="entry name" value="Macrophage colony-stimulating factor 1 receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001169">
        <property type="entry name" value="Macrophage colony-stimulating factor 1 receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000177">
        <property type="entry name" value="Mast/stem cell growth factor receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000025">
        <property type="entry name" value="Platelet-derived growth factor receptor alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030658">
        <property type="entry name" value="CSF-1_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013151">
        <property type="entry name" value="Immunoglobulin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001824">
        <property type="entry name" value="Tyr_kinase_rcpt_3_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF47">
        <property type="entry name" value="MACROPHAGE COLONY-STIMULATING FACTOR 1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00047">
        <property type="entry name" value="ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500947">
        <property type="entry name" value="CSF-1_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000615">
        <property type="entry name" value="TyrPK_CSF1-R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00240">
        <property type="entry name" value="RECEPTOR_TYR_KIN_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 21 26" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="15 25" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="18 27" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="22" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 29" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 21 26" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16 27" id="KW-0675">Receptor</keyword>
    <keyword evidence="34" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="30" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 27 29" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 29" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="14" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="signal peptide" evidence="30">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034611762" description="receptor protein-tyrosine kinase" evidence="30">
        <location>
            <begin position="26"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="29">
        <location>
            <begin position="509"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="32">
        <location>
            <begin position="27"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="32">
        <location>
            <begin position="202"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="32">
        <location>
            <begin position="305"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="31">
        <location>
            <begin position="577"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="723"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="28">
        <location>
            <begin position="725"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="20">
        <location>
            <position position="782"/>
        </location>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="556"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <begin position="583"/>
            <end position="591"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <begin position="584"/>
            <end position="591"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21 26">
        <location>
            <position position="611"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <begin position="659"/>
            <end position="665"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="786"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="787"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="800"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for interaction with phosphotyrosine-binding proteins" evidence="23">
        <location>
            <position position="926"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="48"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="127"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="224"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="418"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRSR" id="PIRSR500947-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PIRSR" id="PIRSR500947-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="RuleBase" id="RU000311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="31">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="32">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005005999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="968" mass="108180" checksum="83584A62AF31AEA1" modified="2022-01-19" version="1">MGSGDVGPGLLLLLLTTPAVWHGSASPVISPDISALVVNVGDPVLLRCSGESEVKWYPEKFANRTNSTLSIPRTTYRDTGTYRCAYVNSSDKGVASVHLYVRDPNNVWYVPYFRISVTKGGNAEFPCFITAPEYGSNVTLIRHDGSKLSPGTNYSFSAEKGIMLYQVEHEQKGQYQCQTVVNGKIEKSSRIRLIVVEGQEKPVQVMVDPADHVRIVGEPFEVTCVVTAPSHKYDVKWVTATNSVKSNGKPDINNGNYIINDTLSIPAVTMEDSGKYTCIANNSAGFKNASTMLRVVERGYVILTPGQATDQDVTEGDSLKLQVHIEAYPKLLHWYWEHTDSLKNSGSNKLSSEMIPKNNWYNNTLFLDHLEGEERGLYTFYASNSETNSSVTFSVSVKSSPRMCSVMVSASDSNKLLCTAIGYPAPHIEWYQCPTHSDRYEDYMLLLNDSSPHVVNTLPFQEVEVESTFPFQDLGANFTFCCVAVNREGSTSDILHSVFRRVMAPPNQLFNPILTTCMCTSVLLLLLLLFLLYKYNQKPKYQVRWKIIEACEGNNYIFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDSVLKVAVKMLKSTADTDEQEALMSELKIMSHLGHHENIVNLLGACTYGGPILVITEYCRYGDLLNFLRKKAEYIIIQDSALDTSLDSTADYKNIELEKKYIRSDSGFASQGLETYVEMRPISSSSSASSDSAQSRGKSSEEDETREDLRPLNLCDLLQFSSQVAQGMAFLASKNCIHRDLAARNVLVSDGRVAKICDFGLARDIMNDSNYVVKGNARLPVKWMAPESIFDCIYTVQSDVWSYGILLWEIFSLGKSPYPGMAVNSKFYSMVKRGYQMARPDFAPLEMYSIMRACWSLEPTQRPTFDQICCFIQKELDLHKEQDYTNLPSTAEEEDSGCDTSGCCEESCEQEESGQPLLKGNNYQFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y7Q1</accession>
    <name>A0A8C2Y7Q1_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NPR2 like, GATOR1 complex subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">NPRL2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NPR2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015729976.1">
        <property type="nucleotide sequence ID" value="XM_015874490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y7Q1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005009754.1">
        <property type="protein sequence ID" value="ENSCJPP00005006155.1"/>
        <property type="gene ID" value="ENSCJPG00005005772.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107319565"/>
    <dbReference type="KEGG" id="cjo:107319565"/>
    <dbReference type="CTD" id="10641"/>
    <dbReference type="GeneTree" id="ENSGT00390000001414"/>
    <dbReference type="OrthoDB" id="338854at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061431">
        <property type="term" value="P:cellular response to methionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045947">
        <property type="term" value="P:negative regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045948">
        <property type="term" value="P:positive regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061462">
        <property type="term" value="P:protein localization to lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009348">
        <property type="entry name" value="NPR2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12991:SF10">
        <property type="entry name" value="GATOR COMPLEX PROTEIN NPRL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12991">
        <property type="entry name" value="NITROGEN PERMEASE REGULATOR 2/TUMOR SUPPRESSOR CANDIDATE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06218">
        <property type="entry name" value="NPR2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="378" mass="43361" checksum="E443D96D1CB62A22" modified="2022-01-19" version="1">MGGRIQCVFFSEFHPTLGPKITYQVPEDFISRELFDTVQVYVITKPELQNKLITVTAMEKKLIGCPVCIEHKKYSRNALLFNLGFVCDARAKACALEPIVKKLAGYLTTLELESGFISNKESKQKLVPIMTILLEELNAKGKCTLPIDESNTIHLKVIEQRPDPQIVQEYDVPVFTQNKDDFFNSQWDLTTQQILPYIDGFRHVQKISAEADVELNLVRIAVQNLLYYGVVTLVSILQYSNVYCTTPKVQDVVDDKCLQEECLAYVTKPGHKRASLRDVFQLYCGLSPGTTVRDLISRYTLQLQRVDERRLIQFGLMKGLIRRLQKFPVKVARDERSLPARLYTGCHSYDEICCKTGMSYKELDERLENDPNIIVCWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y7U4</accession>
    <name>A0A8C2Y7U4_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Histone H3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="13">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the histone H3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y7U4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005010610.1">
        <property type="protein sequence ID" value="ENSCJPP00005006802.1"/>
        <property type="gene ID" value="ENSCJPG00005006285.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286903"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000078">
        <property type="entry name" value="Histone H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000044">
        <property type="entry name" value="Histone H3.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00322">
        <property type="entry name" value="HISTONE_H3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00959">
        <property type="entry name" value="HISTONE_H3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0013">ADP-ribosylation</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-0379">Hydroxylation</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="11 13" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="10 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="15">
        <location>
            <begin position="44"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="136" mass="15312" checksum="46F9809145023F66" modified="2022-01-19" version="1">MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSAAIGALQEASEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y9X2</accession>
    <name>A0A8C2Y9X2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Hairy and enhancer of split-related protein HELT</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">HES/HEY-like transcription factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">HELT</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the HEY family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015716898.1">
        <property type="nucleotide sequence ID" value="XM_015861412.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y9X2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005016332.1">
        <property type="protein sequence ID" value="ENSCJPP00005011136.1"/>
        <property type="gene ID" value="ENSCJPG00005009600.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107313281"/>
    <dbReference type="KEGG" id="cjo:107313281"/>
    <dbReference type="CTD" id="391723"/>
    <dbReference type="GeneTree" id="ENSGT00940000160388"/>
    <dbReference type="OrthoDB" id="6371181at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007417">
        <property type="term" value="P:central nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021858">
        <property type="term" value="P:GABAergic neuron differentiation in basal ganglia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035264">
        <property type="term" value="P:multicellular organism growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000054">
        <property type="entry name" value="hairy and enhancer of split-related protein HELT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050370">
        <property type="entry name" value="HES_HEY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003650">
        <property type="entry name" value="Orange_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10985">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07527">
        <property type="entry name" value="Hairy_orange"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158457">
        <property type="entry name" value="Orange domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51054">
        <property type="entry name" value="ORANGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="11">
        <location>
            <begin position="35"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Orange" evidence="12">
        <location>
            <begin position="111"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00073323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00078769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005011136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="240" mass="26234" checksum="F1F24DF77F186E78" modified="2022-01-19" version="1">MASGLKERRGSAGPPAPRATRVPAAARDAPPASHRTPVSHKVIEKRRRDRINRCLAELGRTVPLALAKQGSGKLEKAEILEMTVQYLRALHSADFPRGREKELLSEFANYFHYGYHECMKNLVHYLTTVERMETKDTKYARILAFLQSKARFAAEPLLAAPPEPDASFPPPPERPPCPAEPFPWPYAPLPAPAALGGPGQQRAAFLPSAQGLERRYLGLLGPPPPGAFGLPPGQHPPAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y9Z5</accession>
    <name>A0A8C2Y9Z5_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pleckstrin homology domain containing A6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">PLEKHA6</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y9Z5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005016509.1">
        <property type="protein sequence ID" value="ENSCJPP00005011268.1"/>
        <property type="gene ID" value="ENSCJPG00005009415.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159692"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="CDD" id="cd13248">
        <property type="entry name" value="PH_PEPP1_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000083">
        <property type="entry name" value="Pleckstrin homology domain-containing family A member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040392">
        <property type="entry name" value="PKHA4-7_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057971">
        <property type="entry name" value="PKHA4-7_TBCA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12752">
        <property type="entry name" value="PHOSPHOINOSITOL 3-PHOSPHATE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12752:SF5">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25541">
        <property type="entry name" value="TBCA_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="62"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="165"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="441"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="758"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1088"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="611"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="193"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="445"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="761"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="806"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="823"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="899"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="912"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1101"/>
            <end position="1115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005011268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1133" mass="128200" checksum="734615F66BB8B92B" modified="2022-01-19" version="1">MSSKAGNKRLANSSSSSSEPSNHTMVTEVAPEKPGGRASRSSRKGIAFGKRSNSMKRNPNAAVTKSGWLYKQASSGVKQWNKRWFVLVDRCLFYYKDEKEESILGSIPLLSFRVAAVQPSDNISRKHTFKAEHAGIRTYFFSAENTEEQESWIQAMGEAARVQIPPTQRSEHEKTDSENIPPSKHHHHHRNAVHHEHPKAEPDSKTRGEGDGRGSEKLERKPERMESKKENLVKANGIAGQEIPSEPSSPYPEAPRVPTSTERPPQPNGWPYTSPSRPGSTAYPPPDGDSAAHRRSFAPRTNPEKIAQRKSSMTQLQQWVNLRRGNVPPEELRSPTRFYPVSRRVPDYYPPYSPQYPEDYQYYPPGVRPDSICSMPAYERVSPPWALEDKRHSFRNGAPYQLREWKEHPGFGRQDVPVWLPGRQPSYFDEVDAASGSLRRMSLQPRSRSVPRSPSQGSYSHTRVYSPVRSPSARFERLPPRGEEIYVDPGTFMMRRSISSPKYDYLGDRRPIPAGMYPYHYPASPTVHDKMDELLDLQLQRNLEYLDQQMSESETLISMVNRMVESSSPRAQLYMQVTSHTPFLGFRSFPFSFSCLEQKLLGKLCEQNKVLREQERLVQQLRAEKESLESALMGTHQELEMFGSQPAYPEKLLHKKESLQNQLINIRVELSQASTALANSTAEYETLESEVSALHDDLWEQLNLDIQNEMLNRQIQKEIWRIQDVMEGLRKNNPSRGTDTAKHRGERALHRAVMHALISEPGPPRPPLPKSYIPLEPPPTVPPLPSESRPWPYPTSPSWQRGGESQRGQPKSTLEQSKKETQRTAASGPTAEGLQSRQEQEAEKQAALNKVGIVPPRTKSPTEEEVVPTTGMLRRSTSGMANGLGSRERPKSAVFANETKVKMSVEEQIDRMKRHQSGSMKEKRRSLQLPGSQQPDTPGTKAPTSYKVVRRHRSIHEVDISDLEAALRSDEPGKVHETPREEIARLRKMELEPQHYDVDINKELSTPDKVLIPERYIELEPDTPLSPEEMKEKQKKVERIKTLIAKSSLQNVIPLGEGEVDAPQDPETQLQEQEKRIEISCALAAEASRRGRMLSAQCATPSPPTSPASPTPPTNPLSSEPSRVADCSHFMRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YAY4</accession>
    <name>A0A8C2YAY4_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Coiled-coil domain containing 152</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">CCDC152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015704136.1">
        <property type="nucleotide sequence ID" value="XM_015848650.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YAY4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005018726.1">
        <property type="protein sequence ID" value="ENSCJPP00005013000.1"/>
        <property type="gene ID" value="ENSCJPG00005010994.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107305945"/>
    <dbReference type="KEGG" id="cjo:107305945"/>
    <dbReference type="CTD" id="100129792"/>
    <dbReference type="GeneTree" id="ENSGT00390000010075"/>
    <dbReference type="OrthoDB" id="10053382at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome Z"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038827">
        <property type="entry name" value="CCDC152"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35253">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35253:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="82"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="206"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005013000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="247" mass="29342" checksum="5265AD399FBE92D4" modified="2022-01-19" version="1">MKKINVVNLDKLLDNFSEIEKKISEINEANKLLVLQLENSNRMLTLSQSREESVKEECTTLRNVIKGLTQTLENQCNIKDENDRLKANIHVLEDKLKASEQEYKDEIEKLTIEIQNKEEDHKSEIAQLSCTMRKKSDAKEMEYKEQIEKKEMEILELTRQLKTQDEEKQNEIIKLQIEFNAKLARVQNKTTKSFSDASVLPQSIYRRKLQHLQEEKNKEIEILRNTIRDLEQRLNKVQDLSLKRRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YBD7</accession>
    <name>A0A8C2YBD7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Coiled-coil and C2 domain-containing protein 1B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">CC2D1B</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CC2D1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015726052.1">
        <property type="nucleotide sequence ID" value="XM_015870566.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YBD7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005020311.1">
        <property type="protein sequence ID" value="ENSCJPP00005014227.1"/>
        <property type="gene ID" value="ENSCJPG00005011893.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107317639"/>
    <dbReference type="KEGG" id="cjo:107317639"/>
    <dbReference type="CTD" id="200014"/>
    <dbReference type="GeneTree" id="ENSGT00390000009595"/>
    <dbReference type="OrthoDB" id="19996at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd08690">
        <property type="entry name" value="C2_Freud-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000104">
        <property type="entry name" value="coiled-coil and C2 domain-containing protein 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037772">
        <property type="entry name" value="C2_Freud"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039725">
        <property type="entry name" value="CC2D1A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006608">
        <property type="entry name" value="CC2D1A/B_DM14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13076">
        <property type="entry name" value="COILED-COIL AND C2 DOMAIN-CONTAINING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13076:SF5">
        <property type="entry name" value="COILED-COIL AND C2 DOMAIN-CONTAINING PROTEIN 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21528">
        <property type="entry name" value="CC2D1A-B_DM14"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00685">
        <property type="entry name" value="DM14"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="6">
        <location>
            <begin position="705"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="118"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="206"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="341"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="529"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="74"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="255"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="358"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00068693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005014227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="879" mass="97686" checksum="AA4C9B7FF2E1E855" modified="2022-01-19" version="1">MLGRRHKKSPQAKGQGAAVAKQLGLFVDFNPEEMLLGAEEGGDDGDLEAELAAITGVKVKEGKAKPKGKVPLPMDHIEKMAAECMKDLNEDEEEAEDEDLEKDTDLLAELQEVLGMEDETGSCEDETVTMEQSVAEAENEEPELQPQTTSLPAVTSELQQTIEKRIVNYKTAISNAKDLGESAKLRRYERGLKTLETMLAAVKRGKKINEEEMPPPVATGKSSSHISQATRAEQENSGDSVSVPAESRAESCAGDEQKTSPKAEQHLELESLQSHAASSPTLETGLHRSSTRDILVKRQKEYKLAALKAKQQGDLEKAKEYMKIGKKFNVVLEALDSGQPVDLQNMPPSPQKLLSLGDVQSTSKQKVPASVGSSQDLAALESQTQEASASLQQPKTVLEALQQRLEKYKSAAAQAKASGDDRKGRMHERIAKQYQDAIRAHKAGRKVNFSELPVPPGFPPLPGVVAPNGDRTIAAVLENASKLASMEENDEEDENELLTQAPVAKKPAQLPGKPTQVVKPITVPSAVAEEESSPECVKQVTSPSSPDKSMDHLPPAAREQLEFLENRKKQYVKAAIKAKKENNLEQAKMYLRTSKTFDLKIEEVKCGKLVDISKLPSPPTDEEGGFIFIHHEDVRLSQKADEVYMQLMKLLKDQHEKCVQYSKQFMHLGNVAETTRFEKLAQGCRKDLDILRLARAQGMDPPSHHFEERTFKMIRIFSELNSTEMHLLIVRGINLPAPPGVAPKDLDAFVKFEFHYPSTEQPQKSKTPVISNSNCPEYNQLFKLNINRNHRGFRRAIRSKGIKFEVYHKGSFFRSDKHVGTAHLKLEKLESQCEVREIIEIFDGRKPTGGKLEVKVRLREPLSGQDLQTITENWLVLEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YC82</accession>
    <name>A0A8C2YC82_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cobalamin binding intrinsic factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">CBLIF</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic cobalamin transport proteins family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2YC82"/>
    <dbReference type="Ensembl" id="ENSCJPT00005022511.1">
        <property type="protein sequence ID" value="ENSCJPP00005015955.1"/>
        <property type="gene ID" value="ENSCJPG00005013157.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063370"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015889">
        <property type="term" value="P:cobalamin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006824">
        <property type="term" value="P:cobalt ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002157">
        <property type="entry name" value="Cbl-bd_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051588">
        <property type="entry name" value="Cobalamin_Transport"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10559:SF15">
        <property type="entry name" value="COBALAMIN BINDING INTRINSIC FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10559">
        <property type="entry name" value="TRANSCOBALAMIN-1/GASTRIC INTRINSIC FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01122">
        <property type="entry name" value="Cobalamin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0170">Cobalt</keyword>
    <keyword evidence="3" id="KW-0171">Cobalt transport</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034612131" evidence="9">
        <location>
            <begin position="34"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>cyanocob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:17439"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>cyanocob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:17439"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="168"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602157-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602157-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="289" mass="31532" checksum="960930674C900E72" modified="2022-01-19" version="1">MWYQRGTAGTEALRMLSVALSIAVLLAAEGCGAEDTVHQDCTINTEERARMLGILQLSTIDSELPNPSVLLALNLAGDSSKARQYLLEQIKETAVKQAKDMSSGQVALYTLALLSSCCNPRHVKVHRQSVDLLSILQEKTDQEVAHWEEYGIPQSTLFSMGLDAQALCVVGAGGYQSAAVILAKQLLSSQGELSVDEQAMMALALVCAYNQTKLQDVRDLLKTALTKVSNALLDKQAEGNGMIGNIYSTGLATQLLLAAGKFYAPPWPWLRHCQPWWHLQPLTCSWTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YCU4</accession>
    <name>A0A8C2YCU4_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Keratin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the avian keratin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2YCU4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005024056.1">
        <property type="protein sequence ID" value="ENSCJPP00005017229.1"/>
        <property type="gene ID" value="ENSCJPG00005014088.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234722"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005882">
        <property type="term" value="C:intermediate filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003461">
        <property type="entry name" value="Keratin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31203">
        <property type="entry name" value="BETA-KERATIN-RELATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31203:SF1">
        <property type="entry name" value="BETA-KERATIN-RELATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02422">
        <property type="entry name" value="Keratin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0416">Keratin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005017229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="98" mass="10016" checksum="979825488F49B250" modified="2022-01-19" version="1">MSCYDLCRPCGPTPLANSCNEPCVRQCQDSRVVIQPSPVVVTLPGPILSSFPQNTAVGSSTSAAVGSILSEEGVPISSGGFGLSGLGSRFSGRRCLPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YCY2</accession>
    <name>A0A8C2YCY2_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Mitofusin 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">MFN1</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2YCY2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005024333.1">
        <property type="protein sequence ID" value="ENSCJPP00005017469.1"/>
        <property type="gene ID" value="ENSCJPG00005014252.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000013727"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098799">
        <property type="term" value="C:outer mitochondrial membrane protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046039">
        <property type="term" value="P:GTP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008053">
        <property type="term" value="P:mitochondrial fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051646">
        <property type="term" value="P:mitochondrion localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010918">
        <property type="term" value="P:positive regulation of mitochondrial membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd09912">
        <property type="entry name" value="DLP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000012">
        <property type="entry name" value="Mitofusin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000214">
        <property type="entry name" value="Mitofusin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006884">
        <property type="entry name" value="Fzo/mitofusin_HR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027094">
        <property type="entry name" value="Mitofusin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10465:SF2">
        <property type="entry name" value="MITOFUSIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10465">
        <property type="entry name" value="TRANSMEMBRANE GTPASE FZO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04799">
        <property type="entry name" value="Fzo_mitofusin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111479">
        <property type="entry name" value="Fzo-like conserved region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="13">
        <location>
            <begin position="161"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="462"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="771"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005017469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="828" mass="92773" checksum="F336BC9DBD523B6A" modified="2022-01-19" version="1">MSARGLEPGHGKVAARRLRRRLPGNGGAWGEGGSAACSAVRPAVRPAVRPVVLQGSAGSCGLASFCSSADVGSLRVLVTLCDFPHSSIMAEATVSPLKHFVLAKKTITAIFEQLLDYVTEGAAFVEATYRNPELEHVATEDELAEIQAYKKKLAVIGEVLSRRHMKVAFFGRTSSGKSSVINAMLWDKVLPSGIGHTTNCFLSVEGTDGDKAYLMTEGSDEKKSVKTVNQLAHALHMDKDLKAGCLVHVFWPKSKCALLRDDLVLVDSPGTDVTTELDSWIDKFCLDADVFVLVANSESTLMNTEKHFFHKVNERLSKPNIFILNNRWDASASEPEYMEDVRRQHMERCLTFLVDELKVIDPVEARNRIFFVSAKEVLSARRQKAQGMPESGGALAEGFQTRFQEFQNFEQIFEECISQSAVKTKFEQHTIRAKQIIDTVKNIMDAINVAAAEKRVLSIEEREDQKDRLDFVRNQLNILTEDTKEKIKRVTEEVENKVSSAMTDEICRLSVLVDEFCLDFHPSPQVLKLYKTELNKHIEDGLGKNLADRCSSEVNESMHQSQQEIIENLKPLLPSGAQNQLHLLIPCRKFDLSYDLNCHSLCADFQEDIVFHFSLGWTSLVNRFLGPKHAQRVLLGLADPSLQIPRPLATTPSAASLPAATPENTSPDDFMVPLIMSLASLTSRTSMSIIVVGGVIWKTVGWKLISVSLSMYGLLYLYERLTWTTKAKERAFKQQFVNYATEKLQMIVSLTSANCSHQVQQEMATTFARLCQQVDVTQKNLEEEIARLSKEIDQLEDIQSHSKHLRTKAIHLENELDRFTKHFLQKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YE39</accession>
    <name>A0A8C2YE39_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fibroblast growth factor</fullName>
            <shortName evidence="5">FGF</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">FGF14</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the heparin-binding growth factors family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2YE39"/>
    <dbReference type="Ensembl" id="ENSCJPT00005027454.1">
        <property type="protein sequence ID" value="ENSCJPP00005019858.1"/>
        <property type="gene ID" value="ENSCJPG00005016065.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156984"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051781">
        <property type="term" value="P:positive regulation of cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23330">
        <property type="entry name" value="beta-trefoil_FGF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000001">
        <property type="entry name" value="Fibroblast growth factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002209">
        <property type="entry name" value="Fibroblast_GF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008996">
        <property type="entry name" value="IL1/FGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11486">
        <property type="entry name" value="FIBROBLAST GROWTH FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00167">
        <property type="entry name" value="FGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00263">
        <property type="entry name" value="HBGFFGF"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00262">
        <property type="entry name" value="IL1HBGF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00442">
        <property type="entry name" value="FGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50353">
        <property type="entry name" value="Cytokine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00247">
        <property type="entry name" value="HBGF_FGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0221">Differentiation</keyword>
    <keyword evidence="4" id="KW-0497">Mitogen</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="225"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU049442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005019858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="257" mass="28660" checksum="B78EF689389DCFDD" modified="2022-01-19" version="1">MCINICRLARRSQSKGNQSLPGYSHAMSKQHFSKEDVRPSKIYLITWDLNSVSKFSLLSKGGRRGRTTTNTNSDPQLKGIVTRLYCRQGYYLQMHPDGSLDGTKDDSSNSTLFNLIPVGLRVVAIQGVKTGLYIALNNEGFLYTSELFTPECKFKESVFENYYVIYSSMLYRQQESGRAWFLGLNKEGQVMKGNRVKKTKPAAHFLPKPLEVAMYREPSLHDIGETVPKAGVTPSKSTSASAIMNGGKPPVNKSKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YEB2</accession>
    <name>A0A8C2YEB2_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Solute carrier family 30 member 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">SLC30A2</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>Zn(2+)(in) + 2 H(+)(out) = Zn(2+)(out) + 2 H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:72627"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Secretory vesicle membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2YEB2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005027966.1">
        <property type="protein sequence ID" value="ENSCJPP00005020279.1"/>
        <property type="gene ID" value="ENSCJPG00005016350.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156072"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030658">
        <property type="term" value="C:transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042589">
        <property type="term" value="C:zymogen granule membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140826">
        <property type="term" value="F:zinc:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010043">
        <property type="term" value="P:response to zinc ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140916">
        <property type="term" value="P:zinc ion import into lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140917">
        <property type="term" value="P:zinc ion import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000002">
        <property type="entry name" value="zinc transporter 3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050681">
        <property type="entry name" value="CDF/SLC30A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11562">
        <property type="entry name" value="CATION EFFLUX PROTEIN/ ZINC TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11562:SF51">
        <property type="entry name" value="PROTON-COUPLED ZINC ANTIPORTER SLC30A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="12" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0864">Zinc transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="15">
        <location>
            <begin position="86"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="16">
        <location>
            <begin position="283"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005020279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="373" mass="40125" checksum="197899019D6D5BF3" modified="2022-01-19" version="1">MQGGLIATPTSSSGHAGSSMWLLASASSSWWGKLWVSERWVNTLPCMAPLVSFCAVGAGVGQAGHLVLPWDAHMLGSGWGSPIHTTGGYLAHSLAILTDAAHLLTDFASIMISLFALWVSSRPATKTMNFGWHRAEILGALLSVLSIWVVTGVLVYLAAQRLLLGDYDIEGSVMLITSACAVAVNIVMGVALHQTGHGHSHGGAHEQPHTHEQPNASVRAAFVHVVGDLLQSVGVLIASYIIFFKPEYKFVDPICTFLFSVLVLGTTLTILRDVLLVLMEGTPRGMDFNAVRDTLLAVGGVEAVHSLHIWALTASQPLLSVHIAINADADSQEVLEEASSRLQRAFRFHTTTIQIESYSEDMRDCRECQPPSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YFD9</accession>
    <name>A0A8C2YFD9_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">[histone H3]-lysine(9) N-methyltransferase</fullName>
            <ecNumber evidence="16">2.1.1.367</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">MECOM</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine = N(6)-methyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60280"/>
            <dbReference type="Rhea" id="RHEA-COMP:15542"/>
            <dbReference type="Rhea" id="RHEA-COMP:15546"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="EC" id="2.1.1.367"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.367" evidence="16"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2YFD9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005030835.1">
        <property type="protein sequence ID" value="ENSCJPP00005022524.1"/>
        <property type="gene ID" value="ENSCJPG00005017916.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157208"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140948">
        <property type="term" value="F:histone H3K9 monomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046329">
        <property type="term" value="P:negative regulation of JNK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043069">
        <property type="term" value="P:negative regulation of programmed cell death"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd19214">
        <property type="entry name" value="PR-SET_PRDM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000112">
        <property type="entry name" value="Mds1 and evi1 complex locus protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000126">
        <property type="entry name" value="Mds1 and evi1 complex locus protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000150">
        <property type="entry name" value="Mds1 and evi1 complex locus protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000159">
        <property type="entry name" value="Mds1 and evi1 complex locus protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000192">
        <property type="entry name" value="Mds1 and evi1 complex locus protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.270.10:FF:000025">
        <property type="entry name" value="MDS1 and EVI1 complex locus protein isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000929">
        <property type="entry name" value="Uncharacterized protein, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044411">
        <property type="entry name" value="PRDM3_PR-SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF66">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21549">
        <property type="entry name" value="PRDM2_PR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0221">Differentiation</keyword>
    <keyword evidence="12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 17" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="20">
        <location>
            <begin position="112"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="243"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="297"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="325"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="353"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="382"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="410"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="439"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="946"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="974"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="1003"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="60"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="540"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="582"/>
            <end position="652"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
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            <end position="852"/>
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    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1024"/>
            <end position="1044"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="18">
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            <begin position="1064"/>
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            <begin position="71"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
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    <feature type="compositionally biased region" description="Pro residues" evidence="18">
        <location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="18">
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    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
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        <location>
            <begin position="1100"/>
            <end position="1120"/>
        </location>
    </feature>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00051161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00066816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005022524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1265" mass="142182" checksum="CC4A7F23FBAF190A" modified="2022-01-19" version="1">MHLMAPMSRTNPAAKGAPGDAELCHAVLGPRGVHQWTFFPSECDECLYESFPELPLEEVPEADGEAANAQCPASVSIQEPSSPTTSSEAFTPKESSPYKATIYIPDDIPIPSEFELRESNIPGAGLGIWTKRKIEVGEKFGPFVGEQRPHLKDPSYGWEILDEFCNVKFCIDASQPDVGNWLKYIKFAGCYDQHNLVACQISDQIFYRVVADIEPGEELLLFMKSEDYSHETMAPDIHEERQYRCEDCDQLFESKAELVDHQKFPCSTPHSAFSMVEEDFQKKLENENDLRDVHEIQECKECDQVFPDLQSLEKHMLSHSEEREYKCDQCPKAFNWKSNLIRHQMSHDSGKHYECENCAKVFTDPSNLQRHIRSQHVGARAHACPECGKTFATSSGLKQHKHIHSSVKPFICEVCHKSYTQFSNLCRHKRMHADCRTQIKCKDCGQMFSTTSSLNKHRRFCEGKNHFAAGGFFGQGISLPGTPAMDKTSMVNMNHANPGLADYFGANRHPAGLTFPTAPGFSFSFPGLFPSGLYHRPPLLPTSSPVKGLPSADQTNKSQSPLMSNPQILPATQDILKALNKQPSVGENKPVELQPERSSEERPHEKLSDQSESSDLDDVSTPSGSDLETTSGSDLESDIESEKEKYKENGKMFKDKVSSLQSLASINNKKEHSNHSIFSPSLEEQTAVSGAVNDSIKAIASIAEKYFGSTGLVGLQDKKVGALPYPSMFPLPFFPAFSQSMYPFPDRDLRPLPLKVEPQSPSELKKIPKGSSESPFDLTTKRKEEKPVTPIPSKPAAPPAASQDQPLDLSMGSRSRASSTKQAEPRKNHVFGEKKGGDLEQRKTSEASLQHARPTPFFMDPIYRVEKRKLTDPLEALKEKYLRPSPGFLFHPQMSAIENMAEKLENFSALKPEANEMIQSMPSMFNFRAPPSALPETLLRKGKERYTCRYCGKIFPRSANLTRHLRTHTGEQPYRCKYCDRSFSISSNLQRHVRNIHNKEKPFKCHLCDRCFGQQTNLDRHLKKHENGNMSGTATSSPHSELESTGAILDDKEDSYFTEIRNFIGNSNHNNQSPRNSEERMNGSHFKDEKAMVTSQNSDLLDDEEAEDEVMMDEEDEESEIAGKTVKEPVTSDIHEGTPEEDYEETSTLDMNCKASPGRYKEEEYNKTGLSALDHIRHFTDSLKMRKMEENQYSEAELAAFNTSQLPEDLKQPLYRKSKSQAYAMMLSLSDKDSLHSASHNSPNMWHSMARAAAESSAIQSISHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YG08</accession>
    <name>A0A8C2YG08_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transmembrane protein 255A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Protein FAM70A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">TMEM255A</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM255 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015716216.1">
        <property type="nucleotide sequence ID" value="XM_015860730.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YG08"/>
    <dbReference type="Ensembl" id="ENSCJPT00005032520.1">
        <property type="protein sequence ID" value="ENSCJPP00005023787.1"/>
        <property type="gene ID" value="ENSCJPG00005018799.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107312917"/>
    <dbReference type="KEGG" id="cjo:107312917"/>
    <dbReference type="CTD" id="55026"/>
    <dbReference type="GeneTree" id="ENSGT00940000160471"/>
    <dbReference type="OrthoDB" id="10034004at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009617">
        <property type="term" value="P:response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028014">
        <property type="entry name" value="TMEM255"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33721:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 255A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33721">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 255B-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14967">
        <property type="entry name" value="FAM70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="89"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="195"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="285"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005023787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="323" mass="35484" checksum="D381BA77B4EF3E2C" modified="2022-01-19" version="1">MRQSLTQQRPGGIALPDSVGSFNRRKRNSLYVTVTLLIVSVLILTVGLAATTRTQNVTVGGYYPGVILGFGSFLGIIGSNLIENKRQMLVASIVFISFGVIAAFCCAIVDGVFAARHIDLRPLYAGRCQYYSKSTTPPEAVCHPQRRAPCTPKIKTNTCFCCDLYNCGNRVEISGGYYEYIDVSSCQDIIHLYHLLWSATILNIVGLFLGIITAAILGGFKDMTPSLPTLNCTVENAHPTVSYYSRPQVTSYNTYYHSTPHLPPYSAYDFQHSSVFPASTPSGLSDDPQSVSPSPSYMWSSNAPPRYSPPYFPPFEKPPPYTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YHR2</accession>
    <name>A0A8C2YHR2_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">FAM20A golgi associated secretory pathway pseudokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">FAM20A</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAM20 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015735491.1">
        <property type="nucleotide sequence ID" value="XM_015880005.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YHR2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005037091.1">
        <property type="protein sequence ID" value="ENSCJPP00005027436.1"/>
        <property type="gene ID" value="ENSCJPG00005021278.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107322218"/>
    <dbReference type="KEGG" id="cjo:107322218"/>
    <dbReference type="CTD" id="54757"/>
    <dbReference type="GeneTree" id="ENSGT00950000182951"/>
    <dbReference type="OrthoDB" id="8583677at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031214">
        <property type="term" value="P:biomineral tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055074">
        <property type="term" value="P:calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009617">
        <property type="term" value="P:response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024869">
        <property type="entry name" value="FAM20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009581">
        <property type="entry name" value="FAM20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12450">
        <property type="entry name" value="DENTIN MATRIX PROTEIN 4 PROTEIN FAM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12450:SF12">
        <property type="entry name" value="PSEUDOKINASE FAM20A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06702">
        <property type="entry name" value="Fam20C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM20 C-terminal" evidence="10">
        <location>
            <begin position="284"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="38"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="59"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="389"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="320"/>
            <end position="323"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="394"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="409"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="409"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR624869-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR624869-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR624869-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005027436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="520" mass="58957" checksum="77BD2107156C72F4" modified="2022-01-19" version="1">MPGPRRDRPVVLLLLGTLLAADLYFHLWPRVRRELAPSAPSCPCRRRSAPSAAPPPPAFAASSSSSSSSSSSPLRRLFAHPLYRAAAPPGPAEPLLGAREALRYYRRKAARWNRRHKLYRQELNLTAAAVLLPLRPESSWLQFHLGISRDGLYPRSSPAVSRLLQDMHDFATISADYSQDEKALLGACDCSQIVKPSGVHLKLVLRFQDFGKAMFKPMRQKREEETPEDFFYFVDFQRHNAEIAAFHLDRILDFRRVPPTVGRLINITKEILEVTRNEVLQSVFFVSPASNVCFFAKCPYMCKTEYAVCGNPHLLEGSLSAFLPSLNLAPRLSIPNPWIRSYSFDEKEEWEVNPLYCDTVREIYPYSSGNRLLNIVDMAIFDFLIGNMDRHHYEMFTKFGDDGFLLHLDNARGFGRHSHDEISILAPLSQCCVIKRTTLLRLQLLAEPEYQLSAVMRESLLQDPLAPVLTEPHLLALDRRLQLILKAVRKCIDTHGEAKVVANDTRQPEAPASDRVKLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7I6PBG4</accession>
    <name>A0A7I6PBG4_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Avian beta-defensin 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">AvBD12</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
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        <lineage>
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            <taxon>Archelosauria</taxon>
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            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
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            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2020" name="J. Hered." volume="111" first="436" last="443">
            <title>Analysis of the Diversity of the AvBD Gene Region in Japanese Quail.</title>
            <authorList>
                <person name="Ishige T."/>
                <person name="Hara H."/>
                <person name="Hirano T."/>
                <person name="Kono T."/>
                <person name="Hanzawa K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="LC509033">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7I6PBG4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005001578.1">
        <property type="protein sequence ID" value="ENSCJPP00005000889.1"/>
        <property type="gene ID" value="ENSCJPG00005000979.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000069121"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
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        <property type="entry name" value="Defensin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044657830" evidence="1">
        <location>
            <begin position="20"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BBP06533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005000889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="65" mass="7156" checksum="2405F07FCA0B60A4" modified="2021-04-07" version="1">MGNLCVVFIFISLLAHGSTQGPDSCNHDRGLCRMGKCIFGEYLAKYCFKPIILCCKPLSLTPTKT</sequence>
</entry>
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            <fullName evidence="3">Uncharacterized protein</fullName>
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        <name type="common">Japanese quail</name>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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            <begin position="70"/>
            <end position="92"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
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        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005000202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="109" mass="11440" checksum="B64056A740989418" modified="2025-10-08" version="2">MICHYSFLIACSKILSLFLAQINALPFLSLCPSTSGSIQAFNNLENLIFGKGFQAKISCGGEQMRSPTELTGAGGGMGVPSPIERMTPPSTSSMSASWAALAGIQQLHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SLW4</accession>
    <name>A0A8C2SLW4_COTJA</name>
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        <submittedName>
            <fullName evidence="4">Family with sequence similarity 167 member A</fullName>
        </submittedName>
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    </gene>
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        <name type="common">Japanese quail</name>
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            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
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    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <text evidence="1">Belongs to the FAM167 (SEC) family.</text>
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    </dbReference>
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    <dbReference type="KEGG" id="cjo:107312431"/>
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    <dbReference type="GeneTree" id="ENSGT00940000159097"/>
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        <property type="component" value="Chromosome 3"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR051771">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11652">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005000712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="211" mass="24161" checksum="6F2976CCE65471F0" modified="2022-01-19" version="1">MSLPKIQIEEALDRTDAGTGSAVPPDDHLRSLKALTEKLRLETRRPSYLEWKAKLEEQAWKSPQPEGDEEGNEAKKGTEDTVPMRKVQLHLNGSPAQDKVTLTSGKIGDFESIDEALTWLRKELAEMRLQDQQLARQLMRLRSDINKLKIEQTCHLHQRMLNDATYELEERDELADLFCDFPLVNSFSLSTPLKLIGVTKMNINSRRFSLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SN97</accession>
    <name>A0A8C2SN97_COTJA</name>
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        <submittedName>
            <fullName evidence="13">HAUS augmin like complex subunit 3</fullName>
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    </protein>
    <gene>
        <name evidence="13" type="primary">HAUS3</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
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            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HAUS3 family.</text>
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    <dbReference type="RefSeq" id="XP_015718382.1">
        <property type="nucleotide sequence ID" value="XM_015862896.2"/>
    </dbReference>
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    <dbReference type="Ensembl" id="ENSCJPT00005001324.1">
        <property type="protein sequence ID" value="ENSCJPP00005000761.1"/>
        <property type="gene ID" value="ENSCJPG00005000834.1"/>
    </dbReference>
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    <dbReference type="GeneTree" id="ENSGT00390000011904"/>
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    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
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        <property type="term" value="C:centrosome"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045171">
        <property type="term" value="C:intercellular bridge"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="C:mitotic spindle microtubule"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
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        <property type="project" value="Ensembl"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR032733">
        <property type="entry name" value="HAUS3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19378">
        <property type="entry name" value="GOLGIN- RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19378:SF3">
        <property type="entry name" value="HAUS AUGMIN LIKE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14932">
        <property type="entry name" value="HAUS-augmin3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02089">
        <property type="entry name" value="HAUSAUGMINL3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAUS augmin-like complex subunit 3 N-terminal" evidence="12">
        <location>
            <begin position="29"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="589"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="304"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="395"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="455"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005000761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="612" mass="69655" checksum="6F6EE782A9118C62" modified="2022-01-19" version="1">MSCGKEFVGILKKIGYPKASELNGEDFDWLFESSEDKSFLEWFCGSVNEQHVVSEEELQDFNHLLESGRPILEGNALDEVLKTCKPSDSGHSSQVEEEELKRLEDEFQSLQKMRNLTVHRYNKLQLMISENSSTLQTLKVKEEEAQKDVKEGLELFNSAMNKFNAELLSLVDRAKKLVSIFTASEQGSDLQPVLFSQLSLAKYLAEEEQCTAALDSYAKRHLYQDRAELAENVHKDNAERVDISKRGTAGACGKSQEIASLQAAYICAQRQLIELQAEEQSLNSAIECAVNMLPSLQSKGTGKEENIEAEISSLNDEVSTIKQQIAQINNEDLPSLLKERAQLFTAPVLMAALDHEIAQQHRFAAKRDEICSHLIRQKASFELIQLAYDIELKKHKDIRCQLEDLIESLQQSSNEMQQRLEALSKETKPEKPRNAISSKDEFACRLYQLLEGENKKQLFKTYTNLEQMAQKLNEDCVTAQDQLAASSQEQTLLLSKLDSDVNALRDSLYCGRNRPLLTSRELTEQFHQLEGDLSKLNQLIVDLTADLKSKRNFLASDKLRQMERNLYVYFFKDQNHLKEMVEKLEQQAEATASGLEDENFTPSEFLNIEKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SND1</accession>
    <name>A0A8C2SND1_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NHS like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">NHSL3</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SND1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005002264.1">
        <property type="protein sequence ID" value="ENSCJPP00005001341.1"/>
        <property type="gene ID" value="ENSCJPG00005001391.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182963"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024845">
        <property type="entry name" value="NHS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23039">
        <property type="entry name" value="NANCE-HORAN SYNDROME PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23039:SF6">
        <property type="entry name" value="SIMILAR TO MKIAA1522 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15273">
        <property type="entry name" value="NHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="914"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1040"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="356"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="542"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="599"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="638"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="679"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="728"/>
            <end position="745"/>
        </location>
    </feature>
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        <location>
            <begin position="752"/>
            <end position="763"/>
        </location>
    </feature>
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        <location>
            <begin position="809"/>
            <end position="835"/>
        </location>
    </feature>
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        <location>
            <begin position="836"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="961"/>
            <end position="977"/>
        </location>
    </feature>
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        <location>
            <begin position="1046"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1101"/>
            <end position="1112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005001341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1146" mass="119632" checksum="89F0D03EE25F22AE" modified="2022-01-19" version="1">MGNAYRKRSPAGSLWPWGRAGKPRAGTAKTENDRRLSVQYKPGDECPDNVFFPSTRPPHLEELHNQAREGLKSLQHQEKQKQTKSAWDHGDTNSLQSCLLSEDDSVSLRSQAASCITDSSSEDALSIRSEMIQRKGSTFRPHDSFSRSSEKASRKRKERRTTVLGIPQHVQKELGLRNSRELRGRPADGHVDSRALQPLLNGGQVSGDAVRIPTIDGNLPPLDVPGGARVRLGALEETDTALQKHIDRVYYDDTLLGRKTSAKLSPMARPKSLAVPGMTTSANPPELLSPVMSISPQGTYMSKIIPNAILPPMVDVVALTRSSVRTLSRCSLVSSSPASVRSLTRFSEHSTRSREPSSSSDNWSHSQSTETIVSNSSTISSQGGSDRRQAEAGLCCEADKAPRSDTDQISVYSSASFSSACSKPAVAAVHTAHGLLAVGPCSVGGSSGRTSPAFSTSSQAEGSDTGSLASERSSARSVSLRKMKKPPAPPRRTFSLHQKVEGENKVLGLPPRPNRRPQQASDVPWSQHLEPFSPTVEDEVFSSTSLSETSSIRSESLAGTNSPKTSRGSPGERGITVVLREPSAQPKWSCPDGSDRTMSPSSGYSSQSGTPTLPTKGLGPPAASPGRVQPQKPDRVCSLQSPALSVSSSLTSISSSASDPVPSETPHCVQSRSDRFVIPPHPKVPAPFSPPPTKPQTPTAPTGPLTPLPDPSVPSAAGQEPSTKPSTKSPPPSPPPAYHPPPPPAKKAEVSPETACEAPTEATWPPPPPPAPEEHDLSMADFPPPDEACFSSLPLPDAVPTPAAGQNHAPSVATTSSSSSTTVSPCIQQQGSPLSPTTPPPGVTVPPPPPLPPPSAPALPPQICLKKATNGSRADSKKEPASRSKSSPVPKEDASLPIVTPSLLQMVRLRSVSVEPPAVPEERVVPQKPIRRALSTRQPNPAKDAVPSNPLHAAVQLKASAVSSAEASGLATKSSGGKTAPPGLEVPAGDGQLSPRHKSPTSTASFIFAKSAKKLVIETPSSPEAQADLKRNLVTELMNFSGQRSAAPAAAQQGKAPAHRKPGKVPPPVAKKPSLGLGPSPSPSPLSPKAPEALGSPAPDGKVKAVAVEEKSGTGSEPVGTAEGRSAAAAEPPAQGMQNCGAGGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SNF2</accession>
    <name>A0A8C2SNF2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="15">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Tyrosyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">YARS1</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:10221"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="15"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2SNF2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005002277.1">
        <property type="protein sequence ID" value="ENSCJPP00005001354.1"/>
        <property type="gene ID" value="ENSCJPG00005001396.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156949"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070212">
        <property type="term" value="P:protein poly-ADP-ribosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042594">
        <property type="term" value="P:response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd02799">
        <property type="entry name" value="tRNA_bind_EMAP-II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00805">
        <property type="entry name" value="TyrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000004">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000040">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000047">
        <property type="entry name" value="tyrosine--tRNA ligase, cytoplasmic isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051270">
        <property type="entry name" value="Tyrosine-tRNA_ligase_regulator"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006330">
        <property type="entry name" value="PRK08560.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586">
        <property type="entry name" value="TRNA-AMINOACYLATION COFACTOR ARC1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586:SF43">
        <property type="entry name" value="TYROSINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10 15" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 14" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="TRNA-binding" evidence="17">
        <location>
            <begin position="411"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="385"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="396"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005001354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="575" mass="63969" checksum="04B85ACA0C1F5EA2" modified="2022-01-19" version="1">MPGLNAGPQCWASMLGLNAGLNAGLNAGPQCWAQCWAQCWGLNAGPRCFVPGSRCPPSPAAVVSLPQEVLGEEKLLSILKEREVKIYWGTATTGRPHVAYFVPMSKIADFLKAGCEVTILFADLHAYLDNMKAPWELLELRTRYYENVIKAMLESIGVPLEKLKFVRGTDYQLSKEYTLDVYRLSSVVTQHDAKKAGAEVVKQVEHPLLSGLLYPGLQALDEEYLKVDAQFGGVDQRKIFTFAEKYLPSLGYAKRIHLMNPMVPGLTGSKMSSSEEDSKIDLLDRKEDVKKKLKKAFCEPGNVENNGVLSFIKHVLFPLKSEFVILREEKWGGNKTYTAYEALEKDFADQVVHPGDLKNSVEVALNKLLDPIREKFNNPELKKLTNAAYPNPSKAKPAEKGTKNSEPETIVPSRLDIRVGKVISVEKHPDADSLYVEKIDVGEPEPRTVVSGLVQFVPKEQLQDRLVVLLCNLKPQKMRGVESQGMVLCASSVGEPRQVEPLDPPAECCAGERVYVEGYEDGEPDDELKPKKKVFEKLQADFRISEDCIAQWKERNFLTKLGNISCKSLKGGSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SNP2</accession>
    <name>A0A8C2SNP2_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">EGF like repeats and discoidin domains 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">EDIL3</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SNP2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005000824.1">
        <property type="protein sequence ID" value="ENSCJPP00005000441.1"/>
        <property type="gene ID" value="ENSCJPG00005000531.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005000829.1">
        <property type="protein sequence ID" value="ENSCJPP00005000443.1"/>
        <property type="gene ID" value="ENSCJPG00005000531.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158144"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome Z"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010811">
        <property type="term" value="P:positive regulation of cell-substrate adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000002">
        <property type="entry name" value="Coagulation factor VIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050633">
        <property type="entry name" value="Neuropilin_MCO_CoagFactor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46806:SF9">
        <property type="entry name" value="EGF-LIKE REPEAT AND DISCOIDIN I-LIKE DOMAIN-CONTAINING PROTEIN 3 PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46806">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01286">
        <property type="entry name" value="FA58C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F5/8 type C" evidence="2">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="2">
        <location>
            <begin position="96"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005000443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="176" mass="20106" checksum="E4D0D50C9F61531C" modified="2022-01-19" version="1">MRVTGVITQGAKRIGSPEYVKSYKIAYSNDGKSWTMYKVKGTNEDMVFRGNVDNNTPYANSFTPPIKSQYIRLYPQVCRRHCTLRMELLGCELSGCSEPLGMKSGHIQDYQITASSVFRTLNMDMFAWEPRKARLDKQGKVNAWTSGHNDQSQWLQVNFQIKFHGHSSSLSFQHAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SP16</accession>
    <name>A0A8C2SP16_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Nucleoporin 58</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">NUP58</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015707588.1">
        <property type="nucleotide sequence ID" value="XM_015852102.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SP16"/>
    <dbReference type="Ensembl" id="ENSCJPT00005001851.1">
        <property type="protein sequence ID" value="ENSCJPP00005001073.1"/>
        <property type="gene ID" value="ENSCJPG00005001132.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107308303"/>
    <dbReference type="KEGG" id="cjo:107308303"/>
    <dbReference type="CTD" id="9818"/>
    <dbReference type="GeneTree" id="ENSGT00730000111111"/>
    <dbReference type="OrthoDB" id="2538017at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024882">
        <property type="entry name" value="NUP58/p45/49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13437">
        <property type="entry name" value="NUCLEOPORIN P58/P45 NUCLEOPORIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13437:SF2">
        <property type="entry name" value="NUCLEOPORIN P58_P45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15967">
        <property type="entry name" value="Nucleoporin_FG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="211"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="580"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="353"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005001073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="602" mass="60458" checksum="772915967B0BC5A1" modified="2022-01-19" version="1">MSAGFSFGAGTLGSAAAAAAGAGGGGGGGGFSFGTTAPSSTGGLNFGTLGSSTATATTSAPSVGFGSGLFGSKPATGFTLGGTSTAGTATTIAPALTLGTPATTSAATTGFSLGFNKPAGSATPFALSITSTSASGLSLSSALTSTPAAGTTGFTLNLGGTTAPTTTASTGLSLGGTLAGLGGSLFQNTSTAATGLGQNALSLTLGTTAAPSSTANEGLGGIDFSSSSDKKSDKTGARPEDSKALKDENLPPVICQDVENLQKFVKEQKQVQEEISRMSSKAMLKVQEDIKALKQLLSVVASGLQRNTLNIDKLKMETAQELKNAEIALRTQKTPPGLQHENTAPADYFRILVEQFEVQLQQYRQQIEELENHLATQANNSHITPQDLSMAMQQIYQTFVALAAQLQSIHENVKMLKDQYLGYRKTFLGDAMDVFEARRTEAKKWQSAPRVTTGPTPFSNIPNAAAVAMAATLTQQQQPATGPQPSLGVSFGTPFGSGIGTGLQSSGLGSSSLGGFGSSSAFGSGATGASSFGFGTTSKPSGSLSAGFGSSTTSGFNFSNPGITASAGLTFGVSNPASAGFGTGGQLLQLKKPPAGNKRGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SQD7</accession>
    <name>A0A8C2SQD7_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SQD7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005004054.1">
        <property type="protein sequence ID" value="ENSCJPP00005002242.1"/>
        <property type="gene ID" value="ENSCJPG00005002439.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000287588"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005002242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="195" mass="20165" checksum="0CD13AF5544BF04D" modified="2022-01-19" version="1">MGSLGDHLCGHLWGQGWGPSMGDGIPYGVTYGFPYGVTYGITYRVRDGIPYGVTSGITYGVTYGITYRVRAGNGIPYGVTYGVPYGVTYGITYGVIYGFPYGVIYGVTYGNGIIYGVSNGITYRVRDGIPYGVTYGVTYGVTYGVSMGSLMGSPMGSLMGSAMGSPMGSLMGSLMGSPMGSLIGSGHCGQCVAMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SRL7</accession>
    <name>A0A8C2SRL7_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MPDU1 (TC 2.A.43.3) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SRL7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005005019.1">
        <property type="protein sequence ID" value="ENSCJPP00005002699.1"/>
        <property type="gene ID" value="ENSCJPG00005003013.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153916"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009312">
        <property type="term" value="P:oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016817">
        <property type="entry name" value="MannP-dilichol_defect-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12226">
        <property type="entry name" value="MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 LEC35 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12226:SF2">
        <property type="entry name" value="MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005002699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="99" mass="10235" checksum="545FF8096220EE18" modified="2022-01-19" version="1">CPGSKMEALRALLVPALIPEVCFEAMKERPLHAQCLKILLSKGLGYGIVAGSAMVKLPQVLKLYGARSGAGLSLGAVGLELLALGGSVAYSVGHGFPFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SRV2</accession>
    <name>A0A8C2SRV2_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Target of myb1 like 2 membrane trafficking protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">TOM1L2</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the TOM1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SRV2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005004193.1">
        <property type="protein sequence ID" value="ENSCJPP00005002331.1"/>
        <property type="gene ID" value="ENSCJPG00005001509.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156940"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045839">
        <property type="term" value="P:negative regulation of mitotic nuclear division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd14238">
        <property type="entry name" value="GAT_TM1L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16996">
        <property type="entry name" value="VHS_Tom1L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.160:FF:000001">
        <property type="entry name" value="TOM1-like protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000003">
        <property type="entry name" value="TOM1-like protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038425">
        <property type="entry name" value="GAT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014645">
        <property type="entry name" value="TOM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027429">
        <property type="entry name" value="TOM1L2_VHS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13856:SF31">
        <property type="entry name" value="TOM1-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13856">
        <property type="entry name" value="VHS DOMAIN CONTAINING PROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036948">
        <property type="entry name" value="TOM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50909">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VHS" evidence="6">
        <location>
            <begin position="20"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="GAT" evidence="7">
        <location>
            <begin position="218"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="164"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="490"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="493"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="514"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR036948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005002331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="523" mass="57642" checksum="C7078C650570C4E0" modified="2022-01-19" version="1">MEFLLGNPFSTPVGQSLEKATDGSLQSEDWTLNMEICDIINETEEGPKDAIRALKKRLNGNKNYREVMLALTVLETCVKNCGHRFHVLVANRDFIDGVLVKIISPKNNPPTIVQDKVLALIQAWADAFRSSPDLTGVVHIYEELKRKGIEFPMADLDALSPIHTPQRSVPEVDPAANMHNSQSQQRMSTSSYSSPSPTAYSPQAPALNVTGPITANSEQIARLRSELDIVRGNTKVMSEMLTEMVPGQEDSSDLELLQELNRTCRAMQQRIVELISRVSNEEVTEELLHVNDDLNNVFLRYERFERYRSGRSTQSASNGVLNEVTEDNLIDLGPGSPAVVSPMVGNSAPSSSLSSQLAGLDLGTNSVSGTLSSLQHCNPRDDFDMFAQTRGSSLAEQRKNVTYEDPQAVKGLASALDVRKQNTGGRRGKGGNSDMEPIDKWLITQGMIPVAQSSVMDDIEEWLTLILLFSFCIAEFDKFLEERAKAAEMVPNLPSPPLEAPTPPTNPSSRKKQERSEDALFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SRV5</accession>
    <name>A0A8C2SRV5_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WD repeat domain 74</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SRV5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005002623.1">
        <property type="protein sequence ID" value="ENSCJPP00005001580.1"/>
        <property type="gene ID" value="ENSCJPG00005001598.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000015119"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037379">
        <property type="entry name" value="WDR74/Nsa1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16038">
        <property type="entry name" value="NOP SEVEN ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16038:SF4">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 74"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005001580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="222" mass="24210" checksum="A6CA2338826B8EF8" modified="2022-01-19" version="1">KRKEALNFGVGRDLGREAAIKVIAWSGEQKQVEMGGGKMGRNRDGTGGVGSVPGRYRPGRFCVRLYDSATPRRRPVLQVSYGEGPLTALALVPGGTSVVVGSARGEMAVIDMRQGRLLRSLRGCAGSIRSLQCHPSLPVVASCGLDRFLRVHSLQDKSIMHKVLVLADQRNIESPPSQAEDSPPPTIKEEEEEGDELWGNMETIPTQEPPPKRRRKDPQPDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SS20</accession>
    <name>A0A8C2SS20_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">B9 domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the B9D family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SS20"/>
    <dbReference type="Ensembl" id="ENSCJPT00005005372.1">
        <property type="protein sequence ID" value="ENSCJPP00005002945.1"/>
        <property type="gene ID" value="ENSCJPG00005003217.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000171855"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036038">
        <property type="term" value="C:MKS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010796">
        <property type="entry name" value="C2_B9-type_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12968">
        <property type="entry name" value="B9 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12968:SF2">
        <property type="entry name" value="B9 DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07162">
        <property type="entry name" value="B9-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51381">
        <property type="entry name" value="C2_B9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="131"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="143"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005002945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="168" mass="17615" checksum="D8C9C9B212FA8F57" modified="2022-01-19" version="1">MGGQWVLMGAVGAYGVSCGVSGVTIGIMGGQWSHCPYGGGGKGPIVLLGWGSHCVPPPQAMAEVHVIGQLLGASGFSQRRLFCKWGLHAGNAWKVLGGLREGQTQVDDPQADDMAHWCHPLDVHFATKGLQGETPQLPHNSPISPPPHTIPLSPFCPPMPPLSPYTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SU33</accession>
    <name>A0A8C2SU33_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Guanylate cyclase soluble subunit alpha-2</fullName>
            <ecNumber evidence="3">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">GUCY1A2</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Has guanylyl cyclase on binding to the beta-1 subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2SU33"/>
    <dbReference type="Ensembl" id="ENSCJPT00005005856.1">
        <property type="protein sequence ID" value="ENSCJPP00005003267.1"/>
        <property type="gene ID" value="ENSCJPG00005003494.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157765"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008074">
        <property type="term" value="C:guanylate cyclase complex, soluble"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019934">
        <property type="term" value="P:cGMP-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007263">
        <property type="term" value="P:nitric oxide mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010750">
        <property type="term" value="P:positive regulation of nitric oxide mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070482">
        <property type="term" value="P:response to oxygen levels"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.260:FF:000002">
        <property type="entry name" value="guanylate cyclase soluble subunit alpha-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1520.10:FF:000003">
        <property type="entry name" value="Guanylate cyclase soluble subunit alpha-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000007">
        <property type="entry name" value="Guanylate cyclase soluble subunit alpha-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1520.10">
        <property type="entry name" value="H-NOX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.260">
        <property type="entry name" value="Haem NO binding associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038158">
        <property type="entry name" value="H-NOX_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011644">
        <property type="entry name" value="Heme_NO-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011645">
        <property type="entry name" value="HNOB_dom_associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042463">
        <property type="entry name" value="HNOB_dom_associated_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45655:SF7">
        <property type="entry name" value="GUANYLATE CYCLASE SOLUBLE SUBUNIT ALPHA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45655">
        <property type="entry name" value="GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07700">
        <property type="entry name" value="HNOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07701">
        <property type="entry name" value="HNOBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="14">
        <location>
            <begin position="510"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="451"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00053451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00073676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005003267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="720" mass="80418" checksum="02DFE22F832A6B6E" modified="2022-01-19" version="1">MSRRKISSESFSSLGSDCPETSPEEEGECPLSRLCWNGSRSPPGPAEPPLTAAAAAAAAAASAGARRVPRRRRVNLDSLGESIRRLTAPAPQTIRQTLQRTLQHFEHQVIGYRDAEKNFHNISNRCTYTDCSGNEETEDVSGILQCTANVLGLKLEEMQEKFGEEFFNICFDENERVLRAVGGTLQDFFNGFDALLEHIRTSFGRQATLESPSFLCKELPEGNLMLHYFHPHQIVGFAMVGMIKAAAKKIYRLDVEVEQVTNDKLCSEGTNPGNCSCLTFLIKEHENANITKALPSGTSHSPLDLRISISTFCRAFPFHLMFDQNMFILQLGEGLRKQLRCDTHKTLKFQDCFDIVSPKISATFERVLLRLSTPFVIRTKLEDTDSENKDKVMEVKGQMIHVPESNSILFLGSPCVDKLDELMGRGLHLSDIPIHDATRDVILVGEQAKAQDGLKKRMDKLKATLERTHQALEEEKKKTVDLLISIFPEEVAQQLWQGQQVQARKFDDVTMLFSDIVGFTAICAQCTPMQVISMLNELYTRFDHQCGFLDIYKVETIGDAYCVAAGLHKKSLSHAKAIALMALKMMELSEEVLTPDGSPIKMRIGIHSGSVLAGVVGVRMPRYCLFGNNVTLASKFESGSHPRRINVSPTTYQLLKKEENFVFIPRSREELPENFPKEIPGICYFLEEPQRVSQPEISSCLSSSPRGEFTTGCCCRQGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SUC2</accession>
    <name>A0A8C2SUC2_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Synaptonemal complex central element protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">SYCE2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SUC2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005005779.1">
        <property type="protein sequence ID" value="ENSCJPP00005003210.1"/>
        <property type="gene ID" value="ENSCJPG00005003444.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000004872"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000801">
        <property type="term" value="C:central element"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007130">
        <property type="term" value="P:synaptonemal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034609">
        <property type="entry name" value="Syce2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28398">
        <property type="entry name" value="SYNAPTONEMAL COMPLEX CENTRAL ELEMENT PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28398:SF1">
        <property type="entry name" value="SYNAPTONEMAL COMPLEX CENTRAL ELEMENT PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="57"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005003210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="156" mass="17645" checksum="80A0F98824B3C8F6" modified="2022-01-19" version="1">MRRTQGRSPSVGNTVGQWAQSGGEWGEIQLAAMPASGPAVLDRQASSRYFAALDSSVGDLRQRAQSLIDRLNDSRKEDHSVMSGFRDSLQLKVSNLAEQLEERLFQLYSLHNELIQERLQELAEVMERVRQAEAELQQVCHTVEEAYRDLCLQPET</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SW05</accession>
    <name>A0A8C2SW05_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SW05"/>
    <dbReference type="Ensembl" id="ENSCJPT00005006963.1">
        <property type="protein sequence ID" value="ENSCJPP00005004083.1"/>
        <property type="gene ID" value="ENSCJPG00005004134.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182865"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051188">
        <property type="entry name" value="PHD-type_Zinc_Finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059102">
        <property type="entry name" value="PHD_PHF7/G2E3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12420">
        <property type="entry name" value="PHD FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12420:SF47">
        <property type="entry name" value="PHD FINGER PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26054">
        <property type="entry name" value="PHD_G2E3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13771">
        <property type="entry name" value="zf-HC5HC2H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="122"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="291"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="291"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="345"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="357"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="375"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="405"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005004083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="431" mass="47509" checksum="2A42E06C757648C7" modified="2022-01-19" version="1">SAVCMLCGRADVDPNICGHMIHQSGIHVHWLCLVSSPMGSFLITARGAPFLPILRRPCSFPSYRSLGATIACAERGCERSFHLPCAQDGECITQFFGQRRSFCSEHRPRQEAQEAPPEGTNCLMCLEPVGDTVSYHTMVCPACRHTWFHRGCIQVGALPSPCRHTWCSCPGCRNILLFFQEMSIMGIQIPVRPWQLILCSSCAAEGTHRCCSHLNNTTDTWECNSCAGLGTGKRQSIALHHTGARQGLAVKAQGSFAGVCLPQEVWQISLQSCRFILITFLPPLTASCAEAESASPSTPETEQETSSPHSCEDGATSEQLRGRRGRRPRAAQRAESDSLISTRQRASGSSWASPAAARRRRPRQRGRSRTRSRSPLQGQTSRSQSWPRRRHASRRMPASGERSGTQRSTRSATLTSSRSSRMPGHRGRSRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SYL1</accession>
    <name>A0A8C2SYL1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nephrocystin-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">NPHP3</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <dbReference type="Ensembl" id="ENSCJPT00005007245.1">
        <property type="protein sequence ID" value="ENSCJPP00005004308.1"/>
        <property type="gene ID" value="ENSCJPG00005004239.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156398"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097546">
        <property type="term" value="C:ciliary base"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097543">
        <property type="term" value="C:ciliary inversin compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003283">
        <property type="term" value="P:atrial septum development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060027">
        <property type="term" value="P:convergent extension involved in gastrulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071908">
        <property type="term" value="P:determination of intestine left/right asymmetry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071910">
        <property type="term" value="P:determination of liver left/right asymmetry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035469">
        <property type="term" value="P:determination of pancreatic left/right asymmetry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071909">
        <property type="term" value="P:determination of stomach left/right asymmetry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001947">
        <property type="term" value="P:heart looping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060993">
        <property type="term" value="P:kidney morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030324">
        <property type="term" value="P:lung development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048496">
        <property type="term" value="P:maintenance of animal organ identity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:non-motile cilium assembly"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:photoreceptor cell maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:regulation of Wnt signaling pathway, planar cell polarity pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:ureter development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="Nephronophthisis 3"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
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        <property type="entry name" value="NPHP3-like_N"/>
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        <property type="entry name" value="NPHP3_ab_dom"/>
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    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
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        <property type="entry name" value="TPR-like_helical_dom_sf"/>
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        <property type="entry name" value="TPR_rpt"/>
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        <property type="entry name" value="NEPHROCYSTIN-3"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870)"/>
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        <location>
            <begin position="264"/>
            <end position="420"/>
        </location>
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            <end position="618"/>
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            <end position="798"/>
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            <begin position="810"/>
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        </source>
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        <source>
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    <sequence length="1295" mass="147161" checksum="FE12E404C9C21E40" modified="2022-01-19" version="1">MGTASSLVSPASGVGEVIEDTYGGGEACEIPVEVKPKARLLRGSLRRVGASRPGGLIGAAFKSTKEYEIFRVSKNNEVASMVKKEAKLDRENKRLRAELQALQKTYQKILREKESALEAKYQAMERAATFEHDRDKVKRQFKIFRETKENEIQDLLRAKRDLEAKLQRLQAQGIQVFDPEESDSDDNCTDVTAAGAQSEYWNGGALGSEPSMGSMMQLQQSFRGPEFAHSSIDVEGPFANINRDDWDAAVASILQVTPLFSHSLWSNTVRCFIISTDETQPEVEIFIRNYSPKLQRICETMGYFFQVVHFPAANENHFKEVRKWEIEKSSLVILLLHLTLPSCLLEDCEEAFLKNPEEKPRLIYHRMGDDRVSSDSVQQLIEQISHVNKAKRIDHVGDVEEGTYEIYTCVEKIIKQDILGCEMTELEGKDLGNKEESTAPEEEVFGDVLWDAHDEQEQMEAFQQASNSTCELGFEKYFERLNDLVAAPAPIPPLLVSGGPGSGKSLLLSKWIHLQQKHSPNTLILYHFVGRPMSTSSESALIIKRLTLKLMQHSWLVSPLTLDPTKLLEEFPRWLEKLSARHQGSIIIIIDSIDQIQQAEKHMKWLIDPLPVNVRVIVSVNVETCPQAWRLWPTLHLDPLNSKDVKALISAECSSANVKLTKEQEKKLERHCRSATTCNALYVTLLAKFNIAGNIDETLQQCFQCQDTVSLYRLVLRSIQESLCSDKEKGLLREILCVIGVSHNGVSESELMELYPELSSAVLASLVHNLHKMCLLTYGCGLLKFQHLQAWEMVRLEYMEEGANIISAYRQKLVDYFTMQLSRDRVTWRSADELPWLFQQQGDKQKLHKCLLNLFVSQNLYKRGHFAELLSYWQLVGKDKSSMAAEYFDSLKEYEKSCEGEESMICLADLYETLGRFLKDLGLLSQAVAPLQRSLEIRETALDPDHPRVAQSLHQLAGVYVQWKKFGNAEQLYKQALEISENAYGAEHLRVARELDALAMLYQKQNKYEQAEQLRKKSFKIRQKAARRKGSLCGFALLRQRALQLEELTLGKDTSDNARTLNELGVLYYLQNNLETAELFLKRSLEMRERVLGPNHPDCAQSLNNLAALYNEKKHYEKAEELYEKALDIRRRALAPDHPSLAYTVKHLAVLYKKMGKLDKAVPLYELAVEIRQKSFGPKHPSVATALVNLAVLYCQMKKQTEALPLYERALKIYEDSFGHMHPRVGETLKNLAVLSYEGGDFEKAAELYKRAMEIKEAETLLIGGKAISRHSSSGDTFSLKSALSPNIFLEHGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SZ96</accession>
    <name>A0A8C2SZ96_COTJA</name>
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            <taxon>Archelosauria</taxon>
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            <taxon>Aves</taxon>
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            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
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            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    </dbReference>
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    <dbReference type="GeneTree" id="ENSGT00390000014429"/>
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        <property type="term" value="P:negative regulation of gene expression"/>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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    </feature>
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            <begin position="199"/>
            <end position="247"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005004584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="287" mass="32197" checksum="09ADE93FF546D8DB" modified="2022-01-19" version="1">MPPPAGPLLLLGLALGLGAGAGAGGGCQLPAEWRPLSEGCRAELASIIVYARVLALHPDPYGAYNYLPWQRDLPSGASSQHNPGGLFYSAEIELLCDQAWGSMLEVPAGSRLNLTGLGYFSCHSHTVMQGYAYFFFLRMDENYILLPHGVNFQEAIFPDTQENRRMFASLFQFSNCSQAQHALSFSSDWEIQEDNRLMCSSVQKALFEEEDRVKKLQQKVATLEKRNKQLRDRVKKVKRSLRQARKNTRHMELMNRKLSEKLASAGGQIPYINSLKQENSHATYLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T368</accession>
    <name>A0A8C2T368_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Whey acidic protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC107323147</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
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            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T368"/>
    <dbReference type="Ensembl" id="ENSCJPT00005010660.1">
        <property type="protein sequence ID" value="ENSCJPP00005006843.1"/>
        <property type="gene ID" value="ENSCJPG00005006323.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000167544"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019731">
        <property type="term" value="P:antibacterial humoral response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00199">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.75.10">
        <property type="entry name" value="Elafin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036645">
        <property type="entry name" value="Elafin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008197">
        <property type="entry name" value="WAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050514">
        <property type="entry name" value="WAP_four-disulfide_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19441:SF30">
        <property type="entry name" value="ELAFIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19441">
        <property type="entry name" value="WHEY ACDIC PROTEIN WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00095">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00003">
        <property type="entry name" value="4DISULPHCORE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00217">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57256">
        <property type="entry name" value="Elafin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51390">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="WAP" evidence="3">
        <location>
            <begin position="12"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="WAP" evidence="3">
        <location>
            <begin position="62"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="245" mass="27007" checksum="66F135E77A0C0519" modified="2022-01-19" version="1">MPSHPQLHISCLPEKPGICPLSEQAEESRCQELCAGDGQCPGDEKCCSSRCGHVCMAPEPDKPGQCPKVRPQLTSEPCTEDDDDCLHDRDCPRQEKCCFSGCAMRCSRPAREHPGWCPRAEPCWDPWHRHRNQCLDDSVCRRDEKCCNTGCTWACMAVPVMAPYPPIPLSIVPSPPFTQVTSMPRPRSAPGECPLLTQSVISPLCHIKASDSAFRVRVPKGMRSRRDLSPDLAMPNCCSASSTCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T4S3</accession>
    <name>A0A8C2T4S3_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Potassium voltage-gated channel subfamily E member 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">MinK-related peptide 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Minimum potassium ion channel-related peptide 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Potassium channel subunit beta MiRP1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">KCNE2</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Apical cell membrane</location>
            <topology evidence="14">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the potassium channel KCNE family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015737482.1">
        <property type="nucleotide sequence ID" value="XM_015881996.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015737489.1">
        <property type="nucleotide sequence ID" value="XM_015882003.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032304714.1">
        <property type="nucleotide sequence ID" value="XM_032448823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T4S3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005012704.1">
        <property type="protein sequence ID" value="ENSCJPP00005008361.1"/>
        <property type="gene ID" value="ENSCJPG00005007495.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107323166"/>
    <dbReference type="KEGG" id="cjo:107323166"/>
    <dbReference type="CTD" id="9992"/>
    <dbReference type="GeneTree" id="ENSGT00940000154497"/>
    <dbReference type="OrthoDB" id="9267127at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005251">
        <property type="term" value="F:delayed rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005242">
        <property type="term" value="F:inward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015459">
        <property type="term" value="F:potassium channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044325">
        <property type="term" value="F:transmembrane transporter binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902282">
        <property type="term" value="F:voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901800">
        <property type="term" value="P:positive regulation of proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097623">
        <property type="term" value="P:potassium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0086091">
        <property type="term" value="P:regulation of heart rate by cardiac conduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901379">
        <property type="term" value="P:regulation of potassium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060307">
        <property type="term" value="P:regulation of ventricular cardiac muscle cell membrane repolarization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000369">
        <property type="entry name" value="K_chnl_KCNE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005425">
        <property type="entry name" value="K_chnl_volt-dep_bsu_KCNE2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15282">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY E MEMBER 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15282:SF8">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY E MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02060">
        <property type="entry name" value="ISK_Channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01605">
        <property type="entry name" value="KCNE2CHANNEL"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0630">Potassium</keyword>
    <keyword evidence="7" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="5" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00039513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00041657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00042904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00042937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005008361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="125" mass="14665" checksum="18DB3A1D19958150" modified="2022-01-19" version="1">MAEIRNFTWAVEDIFKETFLTYMNGWRKNMTEAANELQAKVDAENFDYVILYLMVMIGMFSFIIVAILVSTVKSKRREHSKDPYHQYIVEDWGEKYKSQVLNREDLKCVVHENFGARDKTSPGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T5B3</accession>
    <name>A0A8C2T5B3_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T5B3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005012993.1">
        <property type="protein sequence ID" value="ENSCJPP00005008589.1"/>
        <property type="gene ID" value="ENSCJPG00005007661.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000174565"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="9"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="91"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="175"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005008589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="251" mass="28912" checksum="B8CAEFB9D4530ABB" modified="2022-01-19" version="1">METTSSSRFSIFVMSLLGKIISVPVSLDDMVLDLKVKLFALDSYFYPSRSRLIHGGQWLMNEQTLRHYNITSNSIVHHFLRCKYQPRGGEFSIFVMSLLGKIISVPVSLDDMVLDLKVKLFALDSYFYPSRSRLIHGGQWLMNEQTLRHYNITSNSIVHHFLRCKYQPRGGDSTFPISVKSFSRKMISVPVSLDDTVLDLKVKLFALDSYFYPSQSRLIHGGQELMNEQTLRHYNITSNSSWRLRGDSSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T5Y4</accession>
    <name>A0A8C2T5Y4_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tensin 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T5Y4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005013504.1">
        <property type="protein sequence ID" value="ENSCJPP00005008992.1"/>
        <property type="gene ID" value="ENSCJPG00005007963.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161535"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014020">
        <property type="entry name" value="Tensin_C2-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029023">
        <property type="entry name" value="Tensin_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051484">
        <property type="entry name" value="Tensin_PTEN_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45734">
        <property type="entry name" value="TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45734:SF1">
        <property type="entry name" value="TENSIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10409">
        <property type="entry name" value="PTEN_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01326">
        <property type="entry name" value="PTEN_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51182">
        <property type="entry name" value="C2_TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51181">
        <property type="entry name" value="PPASE_TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatase tensin-type" evidence="2">
        <location>
            <begin position="143"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="C2 tensin-type" evidence="3">
        <location>
            <begin position="320"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="656"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="730"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="576"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="586"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="629"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005008992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="751" mass="80403" checksum="DAA3EC9C1DF76691" modified="2022-01-19" version="1">MQCLAAAQGLQLNKQQRDGCGGEEGGSRVSTAPCLCFPLGGWDGGHGGNISGAGFFLWGLGPTYGAGIPLMGLESLWVLGSCTPHGPGFLFGATVTALPRQVTSPCHPPPPPELRRNTAPVRHVEKMDGSLPFSTVRQHRSLPRLPPPAPPAELSYVTERIIAVRFPGGGDERRFRGHLRDVAALLRARHRDGYTLFNLSEKRHDLVRLHPTVQEFGWPDLLAPPLDTLCAICKALERCLRALPPRVAVLHCRGNKGKVGVVVAAYMHYSRVCASAEQALGTATMQQFCEERVGGDVQPSQRRYMLYFGALLSGTARVNSRPVFLHHVLLPALPRFQPDFQPFLKLYQALQLVHTSGVYSPGPHSVCISLEPALLLKGDVLVQCYQRCGSGRRSVFRAQFHTGALQGERLRLGKEELDLASGDERFPPDATVELLFSSGPDKVEGWAPPGGAVCVDLCTWDPAVRRDSFHGFNLRHQDSNDDLTQVGGPQDKSPHPPVQDRGAPGGTPWEEEPPTAPQSPPGHRPPPTATERWELEQLLGGCGLGGGQEDSPPGAPQGAPVPHSCPVPHRTLTPHSDTEPHRDSVPHSIMAPHSSPAPHSSPVAHRDPVTYSTTPPHGGSAPYRDPVPHSSSASHSTTASYCSTVPHSGAVPHYAAPPYGTLPPHRDSATHSCPVHHSAAAPYSTVPPRSGPVSHSCFVPYSTLPPHGDPVPHSTAAPCCSLVPHSTPTPHSHSVLHSATAPHSNPTAYST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T6E9</accession>
    <name>A0A8C2T6E9_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endoplasmic reticulum-Golgi intermediate compartment protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ERGIC2</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Plays a role in transport between endoplasmic reticulum and Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endoplasmic reticulum membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Golgi apparatus membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ERGIC family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015707016.1">
        <property type="nucleotide sequence ID" value="XM_015851530.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015707023.1">
        <property type="nucleotide sequence ID" value="XM_015851537.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015707030.1">
        <property type="nucleotide sequence ID" value="XM_015851544.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T6E9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005011797.1">
        <property type="protein sequence ID" value="ENSCJPP00005007662.1"/>
        <property type="gene ID" value="ENSCJPG00005006998.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107307987"/>
    <dbReference type="KEGG" id="cjo:107307987"/>
    <dbReference type="CTD" id="51290"/>
    <dbReference type="GeneTree" id="ENSGT00530000063113"/>
    <dbReference type="OrthoDB" id="5541786at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033116">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061852">
        <property type="term" value="C:retrograde transporter complex, Golgi to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045888">
        <property type="entry name" value="Erv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012936">
        <property type="entry name" value="Erv_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039542">
        <property type="entry name" value="Erv_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984:SF30">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07970">
        <property type="entry name" value="COPIIcoated_ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13850">
        <property type="entry name" value="ERGIC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter N-terminal" evidence="10">
        <location>
            <begin position="13"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter C-terminal" evidence="9">
        <location>
            <begin position="166"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="363"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU369013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005007662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="377" mass="42586" checksum="4726C369A72B053B" modified="2022-01-19" version="1">MRRLNRKKTLNLMKELDAFPKVPESYVETSASGGTVSLIAFTTIAFLTIMEFTVYRDTWMKYEYEVDKDFTSKLRINIDITVAMRCQYVGADVLDLAETMVASADGLIYEPVVFDLSPQQREWQRMLQLIQSRLQEEHSLQDVIFKSAFKSASTALPPREDNSLESPDACRIHGHLYVNKVAGNFHITVGKAIPHPRGHAHLAALVSHESYNFSHRIDHLSFGELIPGIINPLDGTEKIASDHNQMFQYFITVVPTKLHTYKISAETHQFSVTERERVINHAAGSHGVSGIFMKYDISSLMVTVTEEHMPFWQFLVRLCGIIGGIFSTTGILHGFGRFVAEVIFCRFRLGSYRPPSDPLPDGHTSNHLPLTTDNSTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T794</accession>
    <name>A0A8C2T794_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Angiotensin II receptor associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">AGTRAP</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T794"/>
    <dbReference type="Ensembl" id="ENSCJPT00005011353.1">
        <property type="protein sequence ID" value="ENSCJPP00005007321.1"/>
        <property type="gene ID" value="ENSCJPG00005006761.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000017402"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004945">
        <property type="term" value="F:angiotensin type II receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008217">
        <property type="term" value="P:regulation of blood pressure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009436">
        <property type="entry name" value="AGTRAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16521">
        <property type="entry name" value="TYPE-1 ANGIOTENSIN II RECEPTOR-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16521:SF3">
        <property type="entry name" value="TYPE-1 ANGIOTENSIN II RECEPTOR-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06396">
        <property type="entry name" value="AGTRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00805">
        <property type="entry name" value="AGTRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005007321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="147" mass="16650" checksum="3595BCB38270E278" modified="2022-01-19" version="1">MELPAVSLKVRGGIWGRAYVGLTSYAWGNFSVLAVGIWAIVQRDSLDAIVMFLSGLLFTVLTDIIHISVYYPLHAYLIDAKRFSMGMAIFSLLLKPGSCYFVYRMYRERGGEYIFNIGRDRSAYETIDQQDASPLWPDSSKTAQQPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T7G9</accession>
    <name>A0A8C2T7G9_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Focadhesin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FOCAD</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="Ensembl" id="ENSCJPT00005013043.1">
        <property type="protein sequence ID" value="ENSCJPP00005008621.1"/>
        <property type="gene ID" value="ENSCJPG00005007688.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000004438"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome Z"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060147">
        <property type="term" value="P:regulation of post-transcriptional gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022542">
        <property type="entry name" value="FOCAD/RST1_DUF3730"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045163">
        <property type="entry name" value="Focadhesin/RST1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021392">
        <property type="entry name" value="Focadhesin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16212:SF4">
        <property type="entry name" value="FOCADHESIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16212">
        <property type="entry name" value="FOCADHESIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12530">
        <property type="entry name" value="DUF3730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11229">
        <property type="entry name" value="Focadhesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3730" evidence="3">
        <location>
            <begin position="590"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="domain" description="Focadhesin C-terminal" evidence="2">
        <location>
            <begin position="1315"/>
            <end position="1902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005008621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1902" mass="211091" checksum="957CEB90E694EF85" modified="2022-01-19" version="1">MTTFTLAATCTCNPQTLRSFPHHPPLAPLLRGPPRRSNSSGGSAEPAPRPQPPPRRSEAQAPVGTQASSAVRAARGPRRCSPLGADPGAGRGYELVSCDRAKMSDDIKKRFEFPNTVIQSQAVGHLIAAVLKENASSDKIMQASHQTPALNLLWEKCCSENVALRTACSEGLVALVAENHAELSYVLHGAVNLIPSARNVHGLVKTIWKLLQIQAVQLGRDGDEAVQNLYGIRNNPHPLITVLENRPDCWPVLLQQITVFFHQCPERAQSSCVAIMAPFLRYLYCEPSQLREYAELRMGLLRILHQPRGPKHKEAPCVLEHRILQLLCDLIPHLQVKDLPQVTEALFFLQELFLSLLRFPVFWKVQLSQFCLQLICFCEVCLNVTGECSSLISLMEDNFELVQEVFPVDQCVIGLALLLLQTPESQQKSILSLAYKLLSSSENVSPTALVLVMPLLQIVSSSSVGDCLQEDDSGTTRQQLATDLLEILKEENGRNKKELTSCKLLFPITSSYCSLYTTWKILELMKEKYAVTDWLSSVRSLLPVTTQVPTHIFLLLAYLLIQEKGDSLRDVLQTAMEVAKADCSQVPSLIPVLIFILGRPLEPALYRDILYTLPSLGVHKVCVPQILRTIHMLGSTPKLRAITLRLMTSLWERQDRIYPELQKFLATSDVPSLSVDKDAQWEKVIAKAACIRDICKQRPYQHGADMLAAISQVLNECTKPDQASPAAIVLQGLQALCEAEVVCINSTWNALSPKLSCDTRPLILKALNELFSLVPSLTVNTNEYEKFKAQVLSFLWKNTQNKDAIVAVSAYKSLSAFGSDEHTILHLPEQAREEIISPEETDMNEDEEEKEVNLFVPGSSYIKLLSLTPDSVLGAFEEFATSLVKQEMTNMPRGVYHSALRGGATRTDQGKTVAGVPNFLLKMYERNKQPGMTPGLAAGMLLCYDLPVHMGRDGKPINRFLASRGRNFQQMLVALIHEVNIQPSEWHRSVLLPQSWLGFMSRTYGAVLQGRQAELEMQLKHGKEDPEDVQYKQFTAWLWVRDMLTDVIKGASKESPVVKGNSILALTGLAAAVAKYESSLSSDTEGMPETVPDFLPMQQWIYMVIETLFSIINSRYRPKGQVFPWFYQKSYSGENTASAIARCCAATALSLLVPAIVVSCKEKVEEVLNMLTAMLPGKPNADESQAVQIHVGLALGMFISRLCEEKVSELPGQQMNLVLMKSLDTLEDCCFDSTLEYNIGCILGVGLVLSFLSHSSQTESRVHVSASLRKLCTYLDSSEDQSRWVQEVLAYSVACSCVSAFSVGIIEAAEAEEAMNKLRILVEKNLQTSGFALALGTVVHGLSVCGHGKAEDLSNKLMPAWIKVVIAEGSPTMQRLAAVNGLVALVGSEGGVIQLKSESIQTSQFQSKLNEVIRTLTQIISFSGQIGLQTNAAGLLGHLHMSCLSSTQSRTSVPPDFSYLPESSFIRAAIDFAIESGKKGPESVPTQLVKVALAPIAVVGESHQYPPVNWASVLSPLMRLNFGDEIKYLCLELAATQAQSSQNAAVLLGMWVAPPLVYSLSMKAQKYLLMSLSLWMKHVAEDKLQAFTEVFLIQQFEVNRTKNPEICQCVLQGLMQAMKIPNPVQYCWGFLCQATEKIFELLPNEIQRSELEMYVSVAKCISEMADSEIDRIVQISKSNVEKAIFTKVYLISQGRLPLKNLSAVIDTSIGYYQKESIVWMFLHSFYHSRIVSHENTGVMKRMDWLLDLMGYIGNLAYKSAPVQNVDRKEVIDFLLWLFAGLVVSWADHSAPLLLGLSANWSPWKHPTVLPELSEDRVGKHPTDKLAVQETLTLLPSSISLLLAKEPWKEQTQKFIDWLISMLESPKEALSKSSTDLLKVTLLALKSLAEFKKKAVWTKAYGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T8D5</accession>
    <name>A0A8C2T8D5_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T8D5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005011961.1">
        <property type="protein sequence ID" value="ENSCJPP00005007802.1"/>
        <property type="gene ID" value="ENSCJPG00005007091.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01140000284157"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="221"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005007802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="361" mass="37750" checksum="007AABE1A6F29CC0" modified="2022-01-19" version="1">MRSPPLLSHSPSCKHSNHALGWSTPKRTPGGWGGVCVLSARPHRALSEPTFARLPPRSCKPQREIRSFQPPAGIQRKPGMESSVQEELRHQAISFGKIPASKAQKYNKTQNAALAAGPAHITKYPAPLFVGMRRVRALFPPGTRRPLCLHKYLCPPGPRAGRQEEMWLIERPQTRPEGNFQVETHCSRPTPRGEKGDGIRREAGPALGPEPGPTLGPEPGPTLGLEPSPTLGLEPSPTLGLEPSPMLGPVPGPTLGLEPSPMLGPEPGPTLGLEPSPMLGPVPGPTLGPEPGPMLGPVPGPTLGPEPGPMLGPVLAPVLCPVLGLMLALVLGPVPGHTVHPGALITAMASHSTALGMAAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TA02</accession>
    <name>A0A8C2TA02_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">T-cell activation Rho GTPase-activating protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">T-cell activation GTPase-activating protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">TAGAP</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TA02"/>
    <dbReference type="Ensembl" id="ENSCJPT00005014742.1">
        <property type="protein sequence ID" value="ENSCJPP00005009890.1"/>
        <property type="gene ID" value="ENSCJPG00005008663.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157993"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035023">
        <property type="term" value="P:regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04402">
        <property type="entry name" value="RhoGAP_ARHGAP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000036">
        <property type="entry name" value="T-cell activation Rho GTPase-activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047886">
        <property type="entry name" value="ARHGAP20-like_RhoGAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23179">
        <property type="entry name" value="T-CELL ACTIVATION RHO GTPASE ACTIVATING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23179:SF26">
        <property type="entry name" value="T-CELL ACTIVATION RHO GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="7">
        <location>
            <begin position="80"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="420"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="585"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="420"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="585"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00074142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00077368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005009890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="682" mass="76131" checksum="936A884199564881" modified="2022-01-19" version="1">THNLCFLSQSKTLNAGNMESLIECPSEVSSCCVSPSPCWALRQDKRKKVISWPFALRRTSTSGDSPGQLDPGLKITLFGQPLAIICGEDDTLPQPVQDLLTILYMKGPSTEGIFRKAANEKARKELKEDLNKGGNVDLGSKTVHLLAVVLKDFLRNIPSKLLSDDLYDKWMLALEKPSKQEKIEELKEVADKLPRPNLVLLKHLLSVLHRISQNADTNRMDANNLAICIGPNMLSPGTGSTLPLEVQKEMNDKVTVLVEFLIEHSSEIFGEDILWPVSTLAGESTEHIDSSTEHLCATHQNDSAYDSPDPEAECCTSELEKPKGRSTGLSRRYPTCVSATSLTNCKNDTNVMDRRYSEPDLSFQDRFESRIRKQKLNKSEDSFPVQQKQLSLENEMLDKRLAILSSQLSSDSLSKTSSSCSLESSDGSVFTSSPLVSPSSPKKTFLNRPQSFCNKPHEDCSTTKREIKKHSMSFSFANQRKTLTKHQSWGPGKYMGFQKDSFTKKDDQFSCRIVQENSPEDIKPLHMPYQRRSRFRSADEVFREVDQRNPGRPPSYEEATKNCVATHCCNLTVQTMRLKVSNQDALPSDPCTSLAQGTAGTASKDLPNDRLSAVNDSAAETETLSVTVGINSRVSLPVTPGVYRLRAMSESCHKNKHEYVARRCSQPIFEAEQIQYAKESYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TAT8</accession>
    <name>A0A8C2TAT8_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TAT8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005014516.1">
        <property type="protein sequence ID" value="ENSCJPP00005009755.1"/>
        <property type="gene ID" value="ENSCJPG00005008541.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153120"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050150">
        <property type="entry name" value="IgV_Light_Chain"/>
    </dbReference>
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        <property type="entry name" value="IMMUNOGLOBULIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005009755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="128" mass="13796" checksum="4084FA21D246806C" modified="2022-01-19" version="1">MQGEVNTLRRLCSTDPTSISALCCRALAFLVLMLPCCTLSPAGCLYAILHPPFVYYGWYQQKSPGSAPVTVIYNDNQRPSNIPSRFSGSTSGSTATLTITGVQAEDEAVYYCGSYEYSSGTGITVSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TB33</accession>
    <name>A0A8C2TB33_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Receptor-type tyrosine-protein phosphatase F</fullName>
            <ecNumber evidence="3">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">PTPRF</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005016124.1">
        <property type="protein sequence ID" value="ENSCJPP00005010978.1"/>
        <property type="gene ID" value="ENSCJPG00005009490.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155060"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035373">
        <property type="term" value="F:chondroitin sulfate proteoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031102">
        <property type="term" value="P:neuron projection regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048679">
        <property type="term" value="P:regulation of axon regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099560">
        <property type="term" value="P:synaptic membrane adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="CDD" id="cd05738">
        <property type="entry name" value="IgI_2_RPTP_IIa_LAR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05739">
        <property type="entry name" value="IgI_3_RPTP_IIa_LAR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000010">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000027">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000036">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000066">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000144">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000015">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000023">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000082">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000128">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000002">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000001">
        <property type="entry name" value="Receptor-type tyrosine-protein phosphatase F isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000098">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase F isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000353">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase F isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050713">
        <property type="entry name" value="RTP_Phos/Ushers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957:SF9">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00014">
        <property type="entry name" value="FNTYPEIII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0358">Heparin-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="12 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="14" id="KW-0675">Receptor</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 20" id="KW-0732">Signal</keyword>
    <keyword evidence="5 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034989107" description="Receptor-type tyrosine-protein phosphatase F" evidence="20">
        <location>
            <begin position="29"/>
            <end position="1941"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1258"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="23">
        <location>
            <begin position="34"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="23">
        <location>
            <begin position="136"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="23">
        <location>
            <begin position="233"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="24">
        <location>
            <begin position="322"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="24">
        <location>
            <begin position="417"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="24">
        <location>
            <begin position="515"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="24">
        <location>
            <begin position="609"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="24">
        <location>
            <begin position="711"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="24">
        <location>
            <begin position="820"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="24">
        <location>
            <begin position="918"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="24">
        <location>
            <begin position="1014"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="21">
        <location>
            <begin position="1349"/>
            <end position="1604"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="22">
        <location>
            <begin position="1524"/>
            <end position="1595"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="21">
        <location>
            <begin position="1636"/>
            <end position="1882"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="22">
        <location>
            <begin position="1813"/>
            <end position="1886"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005010978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1941" mass="216921" checksum="5C15C75B6AD97D9E" modified="2022-01-19" version="1">MVPNFCVSVLTVPAVILCCLMLPDPAKAGAESKPTFMKAPEDQIGISGGVASFVCQATGEPKPRITWMKKGKKVSSQRFEVIEFDDGSGSVLRIQPLRVHRDEAIYECTATNSVGEINTSAKLTVLEEDHLPAGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTATSNGRIKQLRSGALQIENSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVAPRFSIPPSNHEVMPGGSVNLTCVAVGAPMPYVKWMAGVEELTKEDEMPVGRNVLELNNIMQSANYTCVAISSLGMIEATAQITVKALPKPPTEPLVTETTATSVTLTWDSGNSDPISYYVIQYKPKSLEGQFQEVDGVATTRYSIGGLSPFSEYEFRVIAVNNIGRGPPSELVEARTGEQAPSSPPLKVQARMLSASTMLVQWEQPEEPNGQIRGYRVYYTTDSHLPLSMWQKHNTDDSHLTTVGSLITGTTYSIRVLAFTSVGDGPPSDIIQVKTQQGVPAQPADFQAEAESDTRILLTWLPASQERITKYELLYWEGEDGVQQKVEFDPTSSYAVEGLKPDTLYKFRLGAHSELGVGVYTPIVEARTAQSTPSAPPQEVECVSTSSTTIRVSWVPPPAQSRNGVITQYSIAYQAVEGDDSTKHVVDGIGREHSSWEIKDLEKWTEYKVWVRAHTDVGPGPESIPVHVRTDEDVPSAPPRKVEVESVNSTAIRVSWKLPISNKQHGQIRGYQVTYVKLENNEPRGQPVIKDVMLSEAQWRAEDTVDHETVIGGLLPETTYSVTVAAYTTKGDGARSKPKVITTTGAVPGKPTMMISTTAMNTALIQWHPPKEMVGELLGYRLQYRRLDEEKMNTIDFGKRDHHYTVTNLHKGATYLFKLSAKNRAGPGEEFEKEITTAEDVPSGFPQNLRVVGLTTSTTEVAWDPPVLAERNGKIVNYTVVYRDINSQQDLVNITKDTSITLTNLKPDTTYDIKVRARTNKGVGPLSPSIQSRTMPVEQVFAKNFRVNAVMKTSVLLSWEVPDSYKSAVPFKILYNSQSVEVDGHSMKKLISDLQPDTDYSFVLMNRGNSAGGLQHLVSIRTAPDVLQSKPIATNKYIQEGKFTLTLPKVQTTVPVRWYYIVVVPAEQSPSIPTARWRTPDEMELDQLLEAISQGSQSRRQRRQADRLKPYIAAQVDVLPETFTLGDEKNYKGFYNKPLSQDLSYRCFVLASLEDGDTKRYAASPYSDEIVMELASAKQQDEPEMLWVMGPVLAVILIIIIVIAILLFKRKRAHSPSSKDEHSIGLKDSLLAHSSDPVEMRRLNYQTPGMRDHPPIPVTDLADNIDRLKANDGLKFSQEYESIDPGQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETFGDFWRMVWEQRTATIVMMTRLEEKSRVKCDQYWPSRGTETYGMIQVTLLDTVELATYTVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLFAHIQKLTQVPPGESVTAMELEFKLLANSKAHTSRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEVSALLPRAVGDLWVPASQDDIPASPLLTLLPPLPCRTSTSCATERHWSISAALTTMQRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TC69</accession>
    <name>A0A8C2TC69_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Long-chain-fatty-acid--CoA ligase ACSBG2</fullName>
            <ecNumber evidence="10">6.2.1.15</ecNumber>
            <ecNumber evidence="11">6.2.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Acyl-CoA synthetase bubblegum family member 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Arachidonate--CoA ligase ACSBG2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">ACSBG2</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19713"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32395"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57368"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:19714"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(9Z)-octadecenoate + ATP + CoA = (9Z)-octadecenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:33607"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:33608"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:33651"/>
            <dbReference type="ChEBI" id="CHEBI:30245"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57383"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:33652"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15421"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:15422"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:30751"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:30752"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>tetracosanoate + ATP + CoA = tetracosanoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:33639"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:31014"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:65052"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:33640"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the ATP-dependent AMP-binding enzyme family. Bubblegum subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.15" evidence="10"/>
    <dbReference type="EC" id="6.2.1.3" evidence="11"/>
    <dbReference type="RefSeq" id="XP_032296825.1">
        <property type="nucleotide sequence ID" value="XM_032440934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TC69"/>
    <dbReference type="Ensembl" id="ENSCJPT00005016708.1">
        <property type="protein sequence ID" value="ENSCJPP00005011446.1"/>
        <property type="gene ID" value="ENSCJPG00005009830.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107325523"/>
    <dbReference type="CTD" id="81616"/>
    <dbReference type="GeneTree" id="ENSGT00940000155332"/>
    <dbReference type="OrthoDB" id="3633556at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047676">
        <property type="term" value="F:arachidonate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd05933">
        <property type="entry name" value="ACSBG_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF101">
        <property type="entry name" value="ACYL-COA SYNTHETASE BUBBLEGUM FAMILY MEMBER 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="20">
        <location>
            <begin position="118"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00026113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00026121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00035848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00036043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00040479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00042118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00043192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005011446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="744" mass="82335" checksum="0A7DE75986AE1D4D" modified="2022-01-19" version="1">MGMTTCAVEVEKCLCGTMLCETEARSTLAEPAPMAYLNVDAEGNGEVSLDEITISSSSRAAEVCSMEANEDPKTGRSQMKIDLTASSIWTTQQDGEVKLRMDEEGIGSEAPKTIHDLFQEAVRKYGDYNALAYKKNGQWVKLTYKMYYDKCWKTAKSFLKLGLKRFHGVCILGFNSPEWFFADIGAIFAGGLAVGIYTTNSPEACQYVAENCSADILVVENHTQLQKILQVEHKLPHLKAIIQYGEELKEKRPNLYSWKEFLDLGEDVPDSQLRNIIELQKPNQCCTLIYTSGTTGKPKGVMLSHDNLTWTPLAAGRSLMLTDATEKQELVVSYLPLSHVAAQIIDIWLSITFGGQVFFAQPDALKGTLVDTLREVRPTAFLGVPRVWEKIEEKMKSVGAKSSTLRRKVAMWAKGVGLQTNLKWMNGYSEVPMNFRLAKQLVYKKVRKAIGLDRCTKCFTGAAPISRETLEFFLSLNIPVFELYGMSESSGPHTVSIPQAFRLTSCGKEMAGCRTLIDKPDADGTGEICFAGRHIFMGYLNMEEKTKEAIDKDGWLHSGDLGKRDKDGFIYITGRIKELIITAGGENVPPVPIEDAVKEACPLISNAMLVGDKAKFLAMLLTLKCTVNIESGEPGDDLTAEAIEYCQKLGSKATKISEITSSKDKAIYAAIQAAISEVNKRAVSNAQKIQKWVILEKDFSVGGGELGPTMKLKRPAVVQKYKELIDEFYMDANTPTTTENALRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TCM1</accession>
    <name>A0A8C2TCM1_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">A-kinase anchoring protein 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">AKAP7</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="5">Binds cAMP-dependent protein kinase (PKA). Interacts with PRKCA; only the cytoplasmic form is capable of interacting with PRKCA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015714056.1">
        <property type="nucleotide sequence ID" value="XM_015858570.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TCM1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005015158.1">
        <property type="protein sequence ID" value="ENSCJPP00005010184.1"/>
        <property type="gene ID" value="ENSCJPG00005008925.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107311749"/>
    <dbReference type="KEGG" id="cjo:107311749"/>
    <dbReference type="CTD" id="9465"/>
    <dbReference type="GeneTree" id="ENSGT00390000012756"/>
    <dbReference type="OrthoDB" id="277832at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034237">
        <property type="term" value="F:protein kinase A regulatory subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050804">
        <property type="term" value="P:modulation of chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010738">
        <property type="term" value="P:regulation of protein kinase A signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1140.10:FF:000004">
        <property type="entry name" value="A-kinase anchoring protein 7 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019510">
        <property type="entry name" value="AKAP7-like_phosphoesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052641">
        <property type="entry name" value="AKAP7_isoform_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019511">
        <property type="entry name" value="AKAP7_RI-RII-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15934:SF6">
        <property type="entry name" value="A-KINASE ANCHOR PROTEIN 7 ISOFORM GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15934">
        <property type="entry name" value="RNA 2',3'-CYCLIC PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10469">
        <property type="entry name" value="AKAP7_NLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10470">
        <property type="entry name" value="AKAP7_RIRII_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="LigT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034910684" evidence="7">
        <location>
            <begin position="19"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="A-kinase anchor protein 7-like phosphoesterase" evidence="8">
        <location>
            <begin position="142"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="A-kinase anchor protein 7 RI-RII subunit-binding" evidence="9">
        <location>
            <begin position="345"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="375"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="417"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005010184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="445" mass="49594" checksum="985C318793887615" modified="2022-01-19" version="1">MQRVLRRLLPALCSACSAALFAPRNRPMALRPAAAEAGGGEEPIVATGSTPTHDGLENMQQKKEIVEGNKKRTREEEKPCPHADSEDSLMAEMPFAGIDTEDEFAMHTASEINMEKKRKRATGKEIPEGSERKKKKKKQYQPNYFISLPITNPEIAANVRAVQDAIIQKDERLSKAMVHCGSLHVTMLVMHLSSKEEISIAVGALSDSKDSIEDLLKGKTVDLSFQGVDHFKNEVGFVQLAENDHKALLLEIAETMRKIFQEKGILAGEERAFKPHLTFMKLSKSTQLRKQVKKIDSSLYEDYKSHYFGAEILHRFDLCSMLKKKQPNGYYYCESSVFLGEKHAAEPDDAELVSLSKRLVENAVLKAVQQYLEETQNKARQTDGSPVKAEEAASGTKNESNNDTSKKEPRSRLSKGSFAQRNTGPVIQAESNKGAVIHCRGPHEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TEZ5</accession>
    <name>A0A8C2TEZ5_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Adenosylhomocysteinase like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">AHCYL1</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="5">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the adenosylhomocysteinase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TEZ5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005015538.1">
        <property type="protein sequence ID" value="ENSCJPP00005010515.1"/>
        <property type="gene ID" value="ENSCJPG00005009145.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182981"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044233">
        <property type="term" value="C:mitochondria-associated endoplasmic reticulum membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038166">
        <property type="term" value="P:angiotensin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042045">
        <property type="term" value="P:epithelial fluid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010765">
        <property type="term" value="P:positive regulation of sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044070">
        <property type="term" value="P:regulation of monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031440">
        <property type="term" value="P:regulation of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051592">
        <property type="term" value="P:response to calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033353">
        <property type="term" value="P:S-adenosylmethionine cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00401">
        <property type="entry name" value="SAHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1480:FF:000002">
        <property type="entry name" value="Adenosylhomocysteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1480:FF:000007">
        <property type="entry name" value="Adenosylhomocysteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000035">
        <property type="entry name" value="Adenosylhomocysteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1480:FF:000009">
        <property type="entry name" value="Adenosylhomocysteinase like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1480">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042172">
        <property type="entry name" value="Adenosylhomocyst_ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000043">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015878">
        <property type="entry name" value="Ado_hCys_hydrolase_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020082">
        <property type="entry name" value="S-Ado-L-homoCys_hydrolase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00936">
        <property type="entry name" value="ahcY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004005">
        <property type="entry name" value="PRK05476.2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420">
        <property type="entry name" value="ADENOSYLHOMOCYSTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420:SF3">
        <property type="entry name" value="S-ADENOSYLHOMOCYSTEINE HYDROLASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05221">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00670">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001109">
        <property type="entry name" value="Ad_hcy_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00996">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00997">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00738">
        <property type="entry name" value="ADOHCYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00739">
        <property type="entry name" value="ADOHCYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S-adenosyl-L-homocysteine hydrolase NAD binding" evidence="8">
        <location>
            <begin position="285"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="48"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="316"/>
            <end position="321"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="440"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
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            <dbReference type="PIRSR" id="PIRSR001109-1"/>
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            <dbReference type="RuleBase" id="RU004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005010515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="533" mass="58909" checksum="72720D03CCC38B8F" modified="2022-01-19" version="1">MSGPEPSGGEEAKQAKEAEDAEKFSFMATVTKAPKKQIQFADDMQEFTKFPTKTGRRSLSRSISQSSTDSYSSAASYTDSSDDEVSPREKQQTNSKGSSNFCVKNIKQAEFGRREIEIAEQDMSALISLRKRAQGEKPLAGAKIVGCTHITAQTAVLIETLCALGAQCRWSACNIYSTQNEVAAALAEAGVAVFAWKGESEDDFWWCIDRCVNVDGWQANMILDDGGDLTHWVYKKYPNIFKKIRGIVEESVTGVHRLYQLSKAGKLCVPAMNVNDSVTKQKFDNLYCCRESILDGLKRTTDVMFGGKQVVVCGYGEVGKGCCAALKALGAIVYVTEIDPICALQACMDGFRVVKLSEVIRQVDVVITCTGNKNVVTREHLDRMKNSCIVCNMGHSNTEIDVTSLRTPELTWERVRSQVDHIIWPDGKRVVLLAEGRLLNLSCSTVPTFVLSITATTQALALIELYNAPEGRYKQDVYLLPKKMDEYVASLHLPSFDAHLTELTDDQAKYLGLNKNGPFKPNYYRSVPLLGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TFP2</accession>
    <name>A0A8C2TFP2_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial carrier 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">MTCH1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TFP2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005015886.1">
        <property type="protein sequence ID" value="ENSCJPP00005010791.1"/>
        <property type="gene ID" value="ENSCJPG00005009339.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000000020"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10780">
        <property type="entry name" value="MITOCHONDRIAL CARRIER HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10780:SF3">
        <property type="entry name" value="MITOCHONDRIAL CARRIER HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="216"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="69"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005010791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="339" mass="35686" checksum="43CEC3E326F0F8FD" modified="2022-01-19" version="1">IGPTGPIDPIGSTGPTGPTGPTGSIGPKGPTRGGGGGAMAGEAPLPSVALAPPGGGSGPGVGPGRTDGTEGLFVALGAGLAAVSHPLLYVKLLVQVGHEPLPPTVGRNVLGRKVLYLPGFFTYARHIVKVDGKRGLFRGLTPRLISSTLSTITRGSVKKAFPLEDMEHVSNKDDVKTSLRKVVKEVRNGSSASLFSFLGSGVFSAIGRIFKEEGILGFFVGLVPHILGDVIFLWCCNLLAHFINTYAVDDNFSQASVIRSYTKFVMGIAMSMLTYPFLLVGDLMAVNNCGLRAGLPPYAPAFTSWIHCWRYLSSQGQLFRGSSLLFRRAPMQAACFPID</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TG18</accession>
    <name>A0A8C2TG18_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BTB domain containing 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BTBD2</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TG18"/>
    <dbReference type="Ensembl" id="ENSCJPT00005017530.1">
        <property type="protein sequence ID" value="ENSCJPP00005012066.1"/>
        <property type="gene ID" value="ENSCJPG00005010281.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159179"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022008">
        <property type="term" value="P:neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18523">
        <property type="entry name" value="BACK_BTBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18281">
        <property type="entry name" value="BTB_POZ_BTBD1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000037">
        <property type="entry name" value="BTB (POZ) domain containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.420:FF:000004">
        <property type="entry name" value="BTB/POZ domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.820:FF:000004">
        <property type="entry name" value="BTB/POZ domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.820">
        <property type="entry name" value="PHR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012983">
        <property type="entry name" value="PHR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038648">
        <property type="entry name" value="PHR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF6">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08005">
        <property type="entry name" value="PHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="538"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="345"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="426"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="456"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005012066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="946" mass="101835" checksum="F76015C2B9AF6DE3" modified="2022-01-19" version="1">MRSLSCAGFQSSDPIPGTAPCGSRGAGSALLQWRDAPALCVCFPPLPYLPLCPQICPFPLTSAPQTPQICPRPQNCPSEPLISLTTSHSPFTTAHPSPIYPFPLTSTPFIQICPFYLNSAPHTPHNCPPPPICPYALKSAPFTSNLPLLPQIYPSHPSQLPTPPLSAPFPSNLPLLPQIYPFPLKSAPFTSNLPLLPQICPSHPSQLPTPPLSAPFPSNLPLLPQIYPFYLKSTPFTSNLPLLPQICPSYPSQLPTPPLSAPVPSNLPILPQIYPFHLKSAPFTSNLPLLPQIYPFPLTSTPFTSNLPLLPQIYTYALKSTSFTSNLPLLPHICPFPPHICPPLPSEPPPPLTPPPSPRPSPHPFPPPPFPSMPRCCPALFLSPRPTAAPIPSIPSSISFSPFHPAAVSRPPLVVLLLLQRRPAPSRAPHKMAAGGSGPGGLSSSCPQPPPPPPGNGAACAASAASEGTPASPTGLTYNQCGANNPTATAGGGGGGGLGVGAAPPGGGLQREPVYNWQATKPTVQERFAFLFNNEVLSDVHFLVGKGRGTQRIPAHRFVLAVGSAVFDAMFNGGMATTSTEIELPDVEPAAFLALLKFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLKKNLRADNAFMLLTQARLFDEPQLASLCLENIDKNTSDAINAEGFTDIDLDTLVAVLERDTLGIREVRLFGAVVRWSEAECQRQQLQVVPENKRKVLGKALALIRFPLMTIEEFAAGPAQSGILTDREVVSLFLHFTVNPKPRVEFIDRPRCCLRGKECSISRFQQVESRWGYSGTSDRIRFSVNKRIFVVGFGLYGSIHGPTDYQVNIQIIHTDSNTVLGQNDTGFSCDGSSNTFRVMFKEPVEVLPNVNYTACATLKGPDSHYGTKGLRKVIHESPTSGAKTCFTFCYAAGNNNGTSVEDGQIPEIIFYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2THJ2</accession>
    <name>A0A8C2THJ2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">alcohol dehydrogenase (NADP(+))</fullName>
            <ecNumber evidence="9">1.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">S-nitroso-CoA reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">AKR1A1</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>S-nitroso-CoA + NADPH + H(+) = sulfinamide-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:78375"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:145546"/>
            <dbReference type="ChEBI" id="CHEBI:145548"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:78376"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>S-nitrosoglutathione + NADPH + H(+) = S-(hydroxysulfenamide)glutathione + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:63500"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:145544"/>
            <dbReference type="ChEBI" id="CHEBI:229723"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a primary alcohol + NADP(+) = an aldehyde + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15937"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15734"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.2" evidence="9"/>
    <dbReference type="RefSeq" id="XP_015725627.1">
        <property type="nucleotide sequence ID" value="XM_015870141.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2THJ2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005017003.1">
        <property type="protein sequence ID" value="ENSCJPP00005011631.1"/>
        <property type="gene ID" value="ENSCJPG00005009995.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107317439"/>
    <dbReference type="KEGG" id="cjo:107317439"/>
    <dbReference type="CTD" id="10327"/>
    <dbReference type="GeneTree" id="ENSGT00940000156539"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004032">
        <property type="term" value="F:aldose reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047941">
        <property type="term" value="F:glucuronolactone reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047939">
        <property type="term" value="F:L-glucuronate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080007">
        <property type="term" value="F:S-nitrosoglutathione reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046185">
        <property type="term" value="P:aldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110095">
        <property type="term" value="P:cellular detoxification of aldehyde"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019640">
        <property type="term" value="P:D-glucuronate catabolic process to D-xylulose 5-phosphate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044597">
        <property type="term" value="P:daunorubicin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044598">
        <property type="term" value="P:doxorubicin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019853">
        <property type="term" value="P:L-ascorbic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd19106">
        <property type="entry name" value="AKR_AKR1A1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000006">
        <property type="entry name" value="Aldo-keto reductase family 1 member A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044481">
        <property type="entry name" value="AKR1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034464572" description="alcohol dehydrogenase (NADP(+))" evidence="17">
        <location>
            <begin position="22"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="18">
        <location>
            <begin position="49"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="14">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="16">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005011631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="357" mass="40163" checksum="988435EFC05B0F56" modified="2022-01-19" version="1">MLGHSIKASSLIKAMSRLLSAAAITTATAKMSAGCDFVALYNGQKIPLIGLGTWKSEPGQVKETVKHALSVGYRHIDCAAAYSNEAEIGAAFQECLGPNKVIKREDLFVTSKLWNTKHHPEDVEPALRKTLADLKLDYLDLYLMHWPHAFERGDNLFPKNPDGTMRYDYTDYKDTWKAMEKLVEKGLVKAIGLSNFNSRQIDDVLSVATVKPAVLQVECHPYLAQNELIAHCQKRGLVVTAYSPLGSPDRMWKHPDEPVLLEEPGIKKLAEKYKKSPAQIILRWQVQRKVVAIPKSVTPARILQNLQVFDFSLTEEELSHIGNLNKNWRYIVPMLTVDGKPVPRDAGHPHYPFNDPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TJN2</accession>
    <name>A0A8C2TJN2_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein phosphatase, Mg2+/Mn2+ dependent 1M</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">PPM1M</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015730105.1">
        <property type="nucleotide sequence ID" value="XM_015874619.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TJN2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005018282.1">
        <property type="protein sequence ID" value="ENSCJPP00005012652.1"/>
        <property type="gene ID" value="ENSCJPG00005010745.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107319622"/>
    <dbReference type="KEGG" id="cjo:107319622"/>
    <dbReference type="CTD" id="132160"/>
    <dbReference type="GeneTree" id="ENSGT00940000161084"/>
    <dbReference type="OrthoDB" id="416093at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004741">
        <property type="term" value="F:[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF236">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="68"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005012652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="460" mass="51851" checksum="54BC96B12938B18C" modified="2022-01-19" version="1">MSVEWLRRLRRGGPAEQRPGGAQESVPRSPQPNPPLYRRPKFLRGGEESPRGGRAVRGTGPERPLPWSSGYAEVINAEKSEFNEDQAACCQISVRRREPGLEEDQEWLILCSTQFLTGYYWALFDGHGGPEAAIIASNYLHYCIKQKLEEVVGAITEAHPPMHLSGRCVCDSDPQFVEEKHVHAEDVVVGALENAFQECDEVIGQEMEATNQTGGCTALATLYFQGKLYVANAGDSRAILVLKDTIVPMSSEFTPETERQRLQHLAFLFPKLLDGEFTRFEFPRRLKGDDVGQKVLYRDYFMEGWGYKLVEKADLKYPLVHGHGKQARLLGTLSVSRGLGDHQLKVIDTNIEVKPFLSCIPKVNVFDFALNDVKENDVLIMATDGLWDVLCNEEVAHMARSFLAENRTNPHRFSELAKSLVCRARGKKRGHQWMLDESQEASYDDISVFVIPLHNRSEDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TK18</accession>
    <name>A0A8C2TK18_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 16">Histone deacetylase 3</fullName>
            <shortName evidence="16">HD3</shortName>
            <ecNumber evidence="4 16">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">HDAC3</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15 16">Belongs to the histone deacetylase family. HD Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="4 16"/>
    <dbReference type="RefSeq" id="XP_015731472.1">
        <property type="nucleotide sequence ID" value="XM_015875986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TK18"/>
    <dbReference type="SMR" id="A0A8C2TK18"/>
    <dbReference type="Ensembl" id="ENSCJPT00005019446.1">
        <property type="protein sequence ID" value="ENSCJPP00005013549.1"/>
        <property type="gene ID" value="ENSCJPG00005011425.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107320289"/>
    <dbReference type="KEGG" id="cjo:107320289"/>
    <dbReference type="CTD" id="8841"/>
    <dbReference type="GeneTree" id="ENSGT00940000160487"/>
    <dbReference type="OrthoDB" id="1918432at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017053">
        <property type="term" value="C:transcription repressor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042826">
        <property type="term" value="F:histone deacetylase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160009">
        <property type="term" value="F:histone decrotonylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051059">
        <property type="term" value="F:NF-kappaB binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160010">
        <property type="term" value="F:protein de-2-hydroxyisobutyrylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160216">
        <property type="term" value="F:protein lysine delactylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
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    <sequence length="428" mass="48881" checksum="8EC743909D44460E" modified="2022-01-19" version="1">MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCRFHSEDYIDFLQRVSPNNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNNKICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEAFYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVINQVVDYYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTVRNVARCWTYETSLLVDEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQTIFENLKMLNHAPSVQIHDVPSDLLSYDRTDEPDPEERGSEENYSRPEAANEFYDGDHDNDKESDVEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TML2</accession>
    <name>A0A8C2TML2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ETS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ETS family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TML2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005022432.1">
        <property type="protein sequence ID" value="ENSCJPP00005015880.1"/>
        <property type="gene ID" value="ENSCJPG00005013111.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000165272"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000343">
        <property type="entry name" value="Ets at 65A, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000418">
        <property type="entry name" value="Ets_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046328">
        <property type="entry name" value="ETS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849:SF307">
        <property type="entry name" value="FEV TRANSCRIPTION FACTOR, ETS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00178">
        <property type="entry name" value="Ets"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00454">
        <property type="entry name" value="ETSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00413">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00345">
        <property type="entry name" value="ETS_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00346">
        <property type="entry name" value="ETS_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50061">
        <property type="entry name" value="ETS_DOMAIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETS" evidence="6">
        <location>
            <begin position="32"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="145" mass="16605" checksum="21573D6A0A316742" modified="2022-01-19" version="1">MRQGSGEGGWDISCSPCSDGSSDLSGAGSGQIQLWQFLLELLSDRANLNCIAWEGTNGEFKLIDPDEVARRWGERKSKPHMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGLAQVCQPNPWVYHMQGILLEEPQKTEQLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TMY2</accession>
    <name>A0A8C2TMY2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">CSNK2A2</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2TMY2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005020818.1">
        <property type="protein sequence ID" value="ENSCJPP00005014653.1"/>
        <property type="gene ID" value="ENSCJPG00005012207.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000004215"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032435">
        <property type="term" value="P:negative regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905818">
        <property type="term" value="P:regulation of chromosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd14132">
        <property type="entry name" value="STKc_CK2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000059">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000088">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045216">
        <property type="entry name" value="CK2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054:SF34">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="50"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005014653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="360" mass="41994" checksum="373C6B5E1EDEC5FA" modified="2022-01-19" version="1">MHAGLGRGGSEHPVKELGRVPCFPGIISPVRLPSSHSVAAWHAQSNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNIINLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFDIRFYMYELLKALDYCHSMGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGQDNYDQLVRIAKVLGTDELYGYLKKYHIELDPHFNDILGQHSRKRWENFIHSENRHLVSPEVLDLLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQSQPSSENAVLSSGLTTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TN77</accession>
    <name>A0A8C2TN77_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Family with sequence similarity 81 member A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FAM81A</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAM81 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015727893.1">
        <property type="nucleotide sequence ID" value="XM_015872407.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TN77"/>
    <dbReference type="Ensembl" id="ENSCJPT00005021744.1">
        <property type="protein sequence ID" value="ENSCJPP00005015321.1"/>
        <property type="gene ID" value="ENSCJPG00005012711.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107318513"/>
    <dbReference type="KEGG" id="cjo:107318513"/>
    <dbReference type="CTD" id="145773"/>
    <dbReference type="GeneTree" id="ENSGT00390000004985"/>
    <dbReference type="OrthoDB" id="10014002at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140693">
        <property type="term" value="F:molecular condensate scaffold activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029619">
        <property type="entry name" value="FAM81"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22420">
        <property type="entry name" value="PROTEIN FAM81A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22420:SF2">
        <property type="entry name" value="PROTEIN FAM81A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="126"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="225"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00046344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="423" mass="48495" checksum="99F01E39B3C8D760" modified="2022-01-19" version="1">MKRHKSLTRKWPNEAQSSQLSPILKASLNCRKKSLTCLCTDRGSSKQHPFICSSQPLRVRNIPLHSQALTAVPLASASLVDQLEDRILSHEKTTAALVEHAFRIKEDIVSTLHRMQNKGGGDRLARQLLEEHIRNITAIVRQLNRDIEMLQEQIRVRDNLSYGTNSTLKSLEMRQLSGLGDLRGRVARCDAGLARLSAEHKITYERLQSLTKDQHTSKLILESKIKETEIQVSHLLSRVEQAVAQQEAKLKLAYKESAQQLHLLDTKLKNAIEELSSQILSARSWLEQEHERIEKELVQKLDQLSLTFKENTEMSERAIEMKFNQMSEKINKIEEIQKITTEAHETQQSEEKINIRIGKLQNEINEDIKEMKAEVNAGFAAIYESIGSLRQVLEAKMKLDRDELQKQIHQMKQEVPMWAETGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TPT3</accession>
    <name>A0A8C2TPT3_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Beta-crystallin A2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Beta-A2 crystallin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">CRYBA2</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Crystallins are the dominant structural components of the vertebrate eye lens.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the beta/gamma-crystallin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015724335.1">
        <property type="nucleotide sequence ID" value="XM_015868849.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TPT3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005022434.1">
        <property type="protein sequence ID" value="ENSCJPP00005015882.1"/>
        <property type="gene ID" value="ENSCJPG00005013112.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107316865"/>
    <dbReference type="KEGG" id="cjo:107316865"/>
    <dbReference type="CTD" id="1412"/>
    <dbReference type="GeneTree" id="ENSGT00940000160306"/>
    <dbReference type="OrthoDB" id="8688215at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005212">
        <property type="term" value="F:structural constituent of eye lens"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002088">
        <property type="term" value="P:lens development in camera-type eye"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.20.10:FF:000004">
        <property type="entry name" value="Crystallin beta A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.20.10:FF:000002">
        <property type="entry name" value="Crystallin, beta B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.20.10">
        <property type="entry name" value="Crystallins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050252">
        <property type="entry name" value="Beta/Gamma-Crystallin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001064">
        <property type="entry name" value="Beta/gamma_crystallin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011024">
        <property type="entry name" value="G_crystallin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11818:SF7">
        <property type="entry name" value="BETA-CRYSTALLIN A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11818">
        <property type="entry name" value="BETA/GAMMA CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00030">
        <property type="entry name" value="Crystall"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01367">
        <property type="entry name" value="BGCRYSTALLIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00247">
        <property type="entry name" value="XTALbg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49695">
        <property type="entry name" value="gamma-Crystallin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50915">
        <property type="entry name" value="CRYSTALLIN_BETA_GAMMA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0273">Eye lens protein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Beta/gamma crystallin 'Greek key'" evidence="8">
        <location>
            <begin position="52"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Beta/gamma crystallin 'Greek key'" evidence="8">
        <location>
            <begin position="105"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Beta/gamma crystallin 'Greek key'" evidence="8">
        <location>
            <begin position="147"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00042193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="196" mass="23032" checksum="C161304A30B4F823" modified="2022-01-19" version="1">MTSEAMDTLGQYKITVWEEESFQGKRCEFLMECPSIMERGFRKIRSIKVESGPWVGFEYPEYQGQQFILEKGDYPRWEAWSGNSGYRTEHLLSFRPVKCANHNDSKVILYEAENFQGHKFELSDDYPSLQAMGWGNKEVASIKVNAGAWVAYQYPGYRGYQYVLERDRQNGEFKKYSEYSSQAHTNQIQSIRRIQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TPV1</accession>
    <name>A0A8C2TPV1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Succinate dehydrogenase assembly factor 2, mitochondrial</fullName>
            <shortName evidence="4">SDH assembly factor 2</shortName>
            <shortName evidence="4">SDHAF2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">SDHAF2</name>
        <name evidence="4" type="synonym">PGL2</name>
        <name evidence="4" type="synonym">SDH5</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts with SDHA within the SDH catalytic dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SDHAF2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TPV1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005022552.1">
        <property type="protein sequence ID" value="ENSCJPP00005015995.1"/>
        <property type="gene ID" value="ENSCJPG00005013188.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000001149"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010719">
        <property type="term" value="P:negative regulation of epithelial to mesenchymal transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.250:FF:000002">
        <property type="entry name" value="Succinate dehydrogenase assembly factor 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.250">
        <property type="entry name" value="Flavinator of succinate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03057">
        <property type="entry name" value="SDHAF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005631">
        <property type="entry name" value="SDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036714">
        <property type="entry name" value="SDH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028882">
        <property type="entry name" value="SDHAF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12469">
        <property type="entry name" value="PROTEIN EMI5 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12469:SF2">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03937">
        <property type="entry name" value="Sdh5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109910">
        <property type="entry name" value="YgfY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="169" mass="19405" checksum="4A1EF08524AA6503" modified="2022-01-19" version="1">VAQPTVGIQDGRGFALCSLSRLTLCRPVLAMLRAPRGYSGASQGDPGKDVLEMPLPPWKERPNESLDTKRARLLYESRKRGMLENCILLSLFAKENLSRMDERQLNLYDQLINVPSNDWDIYYWATEAKPTPAVFDNEVMAMLKELAKNKKKEQRLRQPDLEYLFESTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TQ26</accession>
    <name>A0A8C2TQ26_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Renin</fullName>
            <ecNumber evidence="3">3.4.23.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC107314259</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.1" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2TQ26"/>
    <dbReference type="Ensembl" id="ENSCJPT00005022537.1">
        <property type="protein sequence ID" value="ENSCJPP00005015980.1"/>
        <property type="gene ID" value="ENSCJPG00005013179.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000167768"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007586">
        <property type="term" value="P:digestion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05478">
        <property type="entry name" value="pepsin_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000004">
        <property type="entry name" value="Pepsin A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000002">
        <property type="entry name" value="Vacuolar aspartic proteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012848">
        <property type="entry name" value="Aspartic_peptidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034162">
        <property type="entry name" value="Pepsin_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF22">
        <property type="entry name" value="PEPSIN A-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07966">
        <property type="entry name" value="A1_Propeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="7" id="KW-0222">Digestion</keyword>
    <keyword evidence="10 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 14" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034538854" description="Renin" evidence="15">
        <location>
            <begin position="16"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="16">
        <location>
            <begin position="74"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="262"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="301"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="378" mass="41803" checksum="0C7D226A0FCCB1A3" modified="2022-01-19" version="1">MKLLLLLGLVALAQCSIHRIPLQKGKSLRKQLKEHGLLEDFLKKHPYNPASKYNPVLTATESYEPMTNYMDASYYGTISIGTPQQDFTVIFDTGSSNLWVPSIYCKSNHHLFDPSKSSTYVSTNETVYIAYGTGSMSGILGYDTVAVSNIDVKNQIFGLSETEPGSFFYYCNFDGILGLAFPSISSSGATPVFDNMMSQDLVSQDLFSVYLSKDGESGSFVLFGGIDPKYTTGGIYWVPLSAETYWQITMDRVTVGKRYVACFFTCQAIVDTGTSLLVMPQRAYNRIIRDLGVSSDGEINCNDISKLPDVTFHINGHAFTLPASDYVLNEEGSCSLGFENMGTPTELGEQWILGDVFIRKYYVIFDRGNNKVGLSPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TQ37</accession>
    <name>A0A8C2TQ37_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TQ37"/>
    <dbReference type="Ensembl" id="ENSCJPT00005023543.1">
        <property type="protein sequence ID" value="ENSCJPP00005016816.1"/>
        <property type="gene ID" value="ENSCJPG00005013793.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00990000203899"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005016816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="98" mass="10797" checksum="98161373CF742B83" modified="2022-01-19" version="1">EHPAGEVTRLDWQLKNQVPRNPPFTAVRITEGEMKSYHDFIGGCIRLECMAKKGICIGLSSPLPTGIQAALLQMNGTECCLQIKKSPENSNENREGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TQL9</accession>
    <name>A0A8C2TQL9_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nonsense-mediated mRNA decay factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">SMG5</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Plays a role in nonsense-mediated mRNA decay.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015739769.1">
        <property type="nucleotide sequence ID" value="XM_015884283.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TQL9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005023790.1">
        <property type="protein sequence ID" value="ENSCJPP00005017008.1"/>
        <property type="gene ID" value="ENSCJPG00005013927.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107324339"/>
    <dbReference type="KEGG" id="cjo:107324339"/>
    <dbReference type="CTD" id="23381"/>
    <dbReference type="GeneTree" id="ENSGT00940000154566"/>
    <dbReference type="OrthoDB" id="5920073at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036464">
        <property type="term" value="C:cytoplasmic ribonucleoprotein granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005697">
        <property type="term" value="C:telomerase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042826">
        <property type="term" value="F:histone deacetylase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051721">
        <property type="term" value="F:protein phosphatase 2A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035303">
        <property type="term" value="P:regulation of dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032204">
        <property type="term" value="P:regulation of telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd09884">
        <property type="entry name" value="PIN_Smg5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000017">
        <property type="entry name" value="protein SMG5 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018834">
        <property type="entry name" value="DNA/RNA-bd_Est1-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019458">
        <property type="entry name" value="Est1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045153">
        <property type="entry name" value="Est1/Ebs1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696:SF7">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696">
        <property type="entry name" value="SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10374">
        <property type="entry name" value="EST1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10373">
        <property type="entry name" value="EST1_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIN" evidence="9">
        <location>
            <begin position="887"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="408"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="846"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="421"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="451"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="484"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="504"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="525"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005017008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1048" mass="117649" checksum="8AD4D50C678D995F" modified="2022-01-19" version="1">MSQGGTGSESGEPEAKVLHTKRLYRAVVEAVHRLDLILGNKAAYQEVFKPENISLRNKLRELCVKLMFLHPVDYGRKAEELLWRKVYYEVIQLIKTNKKHIHSRSALECAYRTHLVAGIGFYQHLLLYIQSHYQLELQCCIDWTHVTDPLMGCKKPVSASEKEMEWAQMACHRCLVYLGDLARYQNELAGVDTELLAERFYYQALSVAPQIGMPFNQLGTLAGSKYYNVEATYCYLRCIQSEVSFEGASGNLKRLYDKAAKMYQQLKKCESRKLSPSRKRCKDIKRLLVSFMYLQSLLQPKSSSLDSELTSLCQSVLEDFNLCLFYLPSPPNLSSATEDEEEYESGYSFLPDLLIFRMVIICFMSVHSLRRAGSKQYSAAIAFTLALFSHLINHVNIRLQAELEEGENPVPAFRSDGTDEPEPREPLSSMEKEGEAELPNHHPREEERKHDCKKSKKYSRLSCLRRRRHPQKADESDLSEGFDSDSSQGSTKGSDGSDSGSEKSDEEAEAAFDVETDSDMNSQESRSDLEDMEDEPGKEGSERGRNGAREGLKNGVDGSGSGECKNTSGSKTESADPAVNGPTSLSASDASIASNLQAMSTQLFQTKRCFRLAPTFSNILLQPSTEPPALKGSLDNKPCINGDVEKPGLAEQDNVSDSEESVLSTKSCRNERSLQEKLEIVSNEGLLLTVKVFLDWLRTNTDFIIMCAQSSQSLWNRLSVLLNLLPSAADLQESGLELCKEVREVLSGAELPELRVNLLLPEDVALRNLPPLRSAHRRLNFEQDRPIFSAVEESIVRICCIRSFGHFVTRLQGSILQFNPELGIFISIAQSERDSVVQQAQAQFHMAAEEARRNRLMRDMAQLRLQLEVSQLEGSLQQPKAQSAMSPYLVLDAQALCQHLAVVKQLAASGRFIIIIPRAVIDSLDFLKKENAGARDGIRYLEAEFKKGNRYIRCQRDVGKSFERHKLKRQDLDAWNLYKILDSCKQLTVSQSSGDDDTTGMVTIITGFQLEDPRALSAPMQAAIQAAAGASVEVKNILEFYKQWKEMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TQM4</accession>
    <name>A0A8C2TQM4_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Scavenger receptor class A member 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">SCARA3</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015715186.1">
        <property type="nucleotide sequence ID" value="XM_015859700.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TQM4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005022226.1">
        <property type="protein sequence ID" value="ENSCJPP00005015721.1"/>
        <property type="gene ID" value="ENSCJPG00005012982.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107312364"/>
    <dbReference type="KEGG" id="cjo:107312364"/>
    <dbReference type="CTD" id="51435"/>
    <dbReference type="GeneTree" id="ENSGT00940000158238"/>
    <dbReference type="OrthoDB" id="5835334at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052376">
        <property type="entry name" value="Oxidative_Scav/Glycosyltrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39082">
        <property type="entry name" value="PHOSPHOLIPASE C-BETA-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39082:SF1">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS A MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="508"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="532"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="548"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="575"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="589" mass="62919" checksum="1172967C801C141A" modified="2022-01-19" version="1">MRAGDLVGGEEEEMPSFCYRPNGRARGGCSQCQKNLSLQTAVKVLYVFSVLLIVAVTVLAALVFKKVNSISGDISSAQMYYEEKILSIQGDLRELDEKSSGNCSLCLETGQLGQELGKLQGELEEIQKMLLVQEVLLDRTSRTHNTLSSSSTEISSEVADCSSSTRQLNESMGQLVAQLGGWRAITSQLDGSLKGLEQERFDVRAAMQQLNFTLGQTSDWIQLIQRKTDEETLTLQKMVTEWKNYTRLFAGLQAASADTGELVRSIQAGVGTAARQVGQNAEGMHDLVLQVMGLQLQLDNISSFLDDHEENMNDLRYHAKYAQNRTAERFETLEGRMASHEIEIGTIFTNINATDSHVHSMLRYLDDVRLSCTLGFHAHAEELYYLNKSLSLVQGTTDLLRERFGLLSARLDFDIRNLSMVMEEMKVVDVRHGEMLKNITILRGVPGLPGPRGLKGDVGIKGPAGSKGEKGDMGSLGSPGPPGSPGPPGLPGPQGERGPLGTKGFPGLKGSKGSFGQSGSKGQMGPKGDMGPPGPEGRPGPTGPPGPQGKLGLPGNPGAVGQIGPTGPKGDPGLRGPPGPPGPPGPPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TRF1</accession>
    <name>A0A8C2TRF1_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Nucleoporin 210</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">NUP210</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NUP210 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015730283.1">
        <property type="nucleotide sequence ID" value="XM_015874797.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005022054.1">
        <property type="protein sequence ID" value="ENSCJPP00005015574.1"/>
        <property type="gene ID" value="ENSCJPG00005012882.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107319711"/>
    <dbReference type="KEGG" id="cjo:107319711"/>
    <dbReference type="CTD" id="23225"/>
    <dbReference type="GeneTree" id="ENSGT00390000009491"/>
    <dbReference type="OrthoDB" id="361283at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1080:FF:000007">
        <property type="entry name" value="Nuclear Pore complex Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003343">
        <property type="entry name" value="Big_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058779">
        <property type="entry name" value="Ig_NUP210_13th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057586">
        <property type="entry name" value="Ig_NUP210_16th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055096">
        <property type="entry name" value="Ig_NUP210_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055097">
        <property type="entry name" value="Ig_NUP210_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055098">
        <property type="entry name" value="Ig_NUP210_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056897">
        <property type="entry name" value="Ig_NUP210_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056898">
        <property type="entry name" value="Ig_NUP210_6th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055099">
        <property type="entry name" value="Ig_NUP210_7th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056899">
        <property type="entry name" value="Ig_NUP210_9th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008964">
        <property type="entry name" value="Invasin/intimin_cell_adhesion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045197">
        <property type="entry name" value="NUP210-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055094">
        <property type="entry name" value="NUP210_Ig15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055095">
        <property type="entry name" value="NUP210_Ig_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23019:SF2">
        <property type="entry name" value="NUCLEAR PORE MEMBRANE GLYCOPROTEIN 210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23019">
        <property type="entry name" value="NUCLEAR PORE MEMBRANE GLYCOPROTEIN GP210-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02368">
        <property type="entry name" value="Big_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26181">
        <property type="entry name" value="Ig_NUP210_13th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26183">
        <property type="entry name" value="Ig_NUP210_14th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22959">
        <property type="entry name" value="Ig_NUP210_15th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25354">
        <property type="entry name" value="Ig_NUP210_16th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22967">
        <property type="entry name" value="Ig_NUP210_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22969">
        <property type="entry name" value="Ig_NUP210_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22963">
        <property type="entry name" value="Ig_NUP210_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24991">
        <property type="entry name" value="Ig_NUP210_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26182">
        <property type="entry name" value="Ig_NUP210_5th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24935">
        <property type="entry name" value="Ig_NUP210_6th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22962">
        <property type="entry name" value="Ig_NUP210_7th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26184">
        <property type="entry name" value="Ig_NUP210_8th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24902">
        <property type="entry name" value="Ig_NUP210_9th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22957">
        <property type="entry name" value="NUP210_Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00635">
        <property type="entry name" value="BID_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49373">
        <property type="entry name" value="Invasin/intimin cell-adhesion fragments"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034630131" evidence="11">
        <location>
            <begin position="22"/>
            <end position="1885"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1807"/>
            <end position="1829"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="12">
        <location>
            <begin position="448"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="12">
        <location>
            <begin position="1075"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1838"/>
            <end position="1885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1853"/>
            <end position="1868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1869"/>
            <end position="1885"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1885" mass="206398" checksum="0EFA551F025FA32E" modified="2022-01-19" version="1">MAPPAPRALLLLLLLHRLAASSSSKLNIPKVLLPFTRSTRVNFTLEASEGCYRWSSTRPEVASIEPADQGERQCSQKAVVQARSSQPTRLTSIIFAEDTMTGQVLRCDAIVDIIHGIQIVSTTRELYLEDSPLELKIQALDSEGNTFSTLAGLVFDWTIVKDTEADGFSDSHNALRILKFLESTYIPPSYISEMEKVAKQGDTILVSGMKTGSSKLKARIHESVYKHVPPAEVRLLILENILLNPAYDVYLLVGTSIKYKVQKIRQGKITELMMPSDQYELQLQNNVLGPEGDPSWPVARLDQETSIVTAMQQGQTNLILGHKSIRMQGVSRLPNSTIYVVNPGYLGFAVHPGDRWVLETGRFYEITIEVYDKSSNKVYLSDNIRINTKLSEEYFEVLKSSLNGSYHYVKAIKKGQTVIDAALTSVVDQDGGVHTLPVPVRNQQDVEIYVPIVLSPSILTFPWQPKAGVYQYTIQAHGGSGNFSWTCSNQAVATVTVKGVMTTGSDIGISIIQAIDVQNPLHYGEMKVYVTEPSGMEFIPCQVEARVGQVLELPLRINGLTNVETGEIVPLSDCSHFDLVVEVENRGVFRPLQGRLKPTADFCSGVRVKAETQGYTTLVVSYTHAHVHLSASITIAAYLPLKTIDPPSVALVTLGSSKDILFEGGPRPWVQEPSKFFRNITAEDPESIGLSLFAPPTPRNNIQHWVQVSCRSLGEQVIALTVGNHPTMTNPFPAVEPAVVKFICAVPSRLTLTPIYGSPQLDHSCPLLQQNKQLVPVSNYRNPVLDLAAYDQHGSKFDNFSSLSVVWESTKSSLANIEPDMPMELTLKDDGSGQRKMHGLQTILVHHKSGTTAISATATGYQQSHLKAAKVKTPYESLLPVSATIELILVEDVRVSPTEVSIYNHPDIQAELFIKEGSGYFFINTSVANVVSVALEETQGIALVHPLLPGSVTVMVHDLCLAFPEPAKAEVYVSDIQELYVRVVDKVEIGKTVKAFIRVLDDSKKPFLAKYFAVMDLKLRAASQIVSLVPLGEALDDHTAAFLVHGIAIGQTSLTASVADKRGQRINSAPQQIEVFPPFRLLPRQVTLIIGAVIQITSEGGPQPQSNIIFSITDEKIASVNSTGLVRGLAIGNGTVTGVVQAVDAETGKLVVVSQDKVEVEVVQLTAVRIRAPITRMKTGTQMPVYVMGITSSQTPFSFGNAVPGLTFHWSVTKRDTLDIKTRHSEASFQLPAKYNFAMDVYGKVKGRTGLKVVVKVLDPAANQFYNMARELSDEIQIQVFEKLHLVTPDVETEQILMSPNSFIKLQTNRDRVASLSYRVLDGPDKVPVVKIDERGFLNSGSLIGSSTIEVISQESFGINQTIVAAVKVYPISYLRISMSPILRTQNKEALVALPLGVTLMFTVHFHDNSGDTFHSHNSVLNFATNRDDFVQIGKGATNNTFVIRTVNVGLTLLKVWDAEHSGIADYIPLPVQHAIFPELTDVVVGDVLCLSTLLINQEGLPGIWSSSSNSVLQIDSKTGVAVARDSGVATVYYEIPGLLKTYREVSINTPQRTTAMHISGVKTSVQGVAASKVIVLIGERNKNLQGECLPAQIEAIAELQPQSIISCHLKFDSDAFDFPARDIFTAEPGFDAVSGHYTCSITMHRLTDKQLKHLSMSKTALRVTASIQGSQFSGEQIGTEVPFNPGFYADQTEMLLSNHYTSADVKIFGATEILDTLEVKCGSPTVKAFEKEKSYGLPSYIVYTISLSDPRVSSQGSLSTTLTVSSPMTDQTITIPVTVIYLTDRTGAPVRHGASLFHHFLDSYQVMFFTLFALLAGTAVMIIAYHAVFTQKEQHAHPAFTPRTPPQHSHNSFSVSPVLSFSPQSSSRKTTPSSTLWSTDYGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TRP8</accession>
    <name>A0A8C2TRP8_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Regulator of microtubule dynamics protein 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Protein FAM82A2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Protein FAM82C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">RMDN3</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Spindle pole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the RMDN family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015718732.1">
        <property type="nucleotide sequence ID" value="XM_015863246.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TRP8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005023401.1">
        <property type="protein sequence ID" value="ENSCJPP00005016688.1"/>
        <property type="gene ID" value="ENSCJPG00005013689.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107314217"/>
    <dbReference type="KEGG" id="cjo:107314217"/>
    <dbReference type="CTD" id="55177"/>
    <dbReference type="GeneTree" id="ENSGT00950000182992"/>
    <dbReference type="OrthoDB" id="512473at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045171">
        <property type="term" value="C:intercellular bridge"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097431">
        <property type="term" value="C:mitotic spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044232">
        <property type="term" value="C:organelle membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049039">
        <property type="entry name" value="RMD1-3_a_helical_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056">
        <property type="entry name" value="REGULATOR OF MICROTUBULE DYNAMICS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056:SF18">
        <property type="entry name" value="REGULATOR OF MICROTUBULE DYNAMICS PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21033">
        <property type="entry name" value="RMD1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="41"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="145"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="98"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00041960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005016688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="470" mass="52930" checksum="D641D5642A999952" modified="2022-01-19" version="1">MARPGPGRLALGLALGAAGLGLSLGLLWAWRRRRRRRGRGAAVERAGGTAVRGDGEEAAGRRRQALPRKAAPVEAGGDYAVYTPLLTQGEQVDVLERLDFVLTNISELRKEVEELQNSLQHLAADIVGEVRSHLEETQRATRRRRFPFYRERSDSTGSSSIYFTANSGATNTDDGESEGGYTTANAESDYDRESEKESEEGEDEVSCETVRTARRDSLDLVNEDETRLMLDSSLDEGLGQLLQQADHLHNGDEQEKREGFQLLLNNKLAYADQGDFLWRLARAHSDMYDIIEDTDEKKSYASDGKEELEIAFQKWDQSAECHQWYAILCGQLAEHESIQKRIQTAYIFKEHIDKAIALKPEDPKSYYLLGRWCYQVSHLGWLEKKTASALFETPPTATVQDALQNFLKVEELSPGFSKAVRVYIAKCYKDLGNNSAALLWINLASELPVNTKEDSETERELEEMRSILEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TS44</accession>
    <name>A0A8C2TS44_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Coactosin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">COTL1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Binds to F-actin in a calcium-independent manner. Has no direct effect on actin depolymerization. Acts as a chaperone for ALOX5 (5LO), influencing both its stability and activity in leukotrienes synthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with 5-lipoxygenase (ALOX5/5LO) in a calcium-independent manner. Binds to F-actin with a stoichiometry of 1:2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the actin-binding proteins ADF family. Coactosin subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TS44"/>
    <dbReference type="Ensembl" id="ENSCJPT00005025180.1">
        <property type="protein sequence ID" value="ENSCJPP00005018097.1"/>
        <property type="gene ID" value="ENSCJPG00005014725.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000012498"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11282">
        <property type="entry name" value="ADF_coactosin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000018">
        <property type="entry name" value="Coactosin-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829:SF29">
        <property type="entry name" value="COACTOSIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829">
        <property type="entry name" value="CORTACTIN AND DREBRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="10">
        <location>
            <begin position="295"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="65"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="186"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="82"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="201"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00058385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00062335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00068121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005018097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="435" mass="45666" checksum="AB1A293AF42F9DED" modified="2022-01-19" version="1">YCKIQRPGVGGFALRCAGSWVLRLCSTTSGEINSKLGSAQSSRSSPLCLQTAYCCPGVFPALEAEPGRGRSPHPNVAQPRTAAPPPAPGALRPRPPARTAACTARLPLTAVPRGSAALCPAPAGSRTLRRYSRHPTAPVLPAHRAAPCLPLGYLPCARPGSGPRRCSIFLLLLFLLPPAGATQTPLAANTPSAAPRITAPGPSPPALRPPSPASPPPGSCITPGPQEGRARAGSTQPIGSIGAAWGGPVLAAGSARLGWARRCAARCGAAAAAAEGPISAPLRGRQPVSPNVPMATKIDKEACREAYNLVRDDATEVNWVTFKYNGSTIVPGDQGVDYETFKRKCTDDVRLFGFVRFTTGDAMSKRVKFALITWIGEDVSGLQRAKTGTDKTLVKEVVQNFAKEFVISDHKELDEDYIKNELKKAGGANYDAQTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TU64</accession>
    <name>A0A8C2TU64_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="26">Hyperpolarization activated cyclic nucleotide gated potassium channel 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="26" type="primary">HCN3</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>Na(+)(in) = Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:34963"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the potassium channel HCN family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TU64"/>
    <dbReference type="Ensembl" id="ENSCJPT00005024284.1">
        <property type="protein sequence ID" value="ENSCJPP00005017426.1"/>
        <property type="gene ID" value="ENSCJPG00005014222.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154743"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098855">
        <property type="term" value="C:HCN channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030552">
        <property type="term" value="F:cAMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005272">
        <property type="term" value="F:sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003254">
        <property type="term" value="P:regulation of membrane depolarization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000031">
        <property type="entry name" value="Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.630:FF:000002">
        <property type="entry name" value="Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000007">
        <property type="entry name" value="Putative potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.630">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013621">
        <property type="entry name" value="Ion_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051413">
        <property type="entry name" value="K/Na_HCN_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003938">
        <property type="entry name" value="K_chnl_volt-dep_EAG/ELK/ERG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45689">
        <property type="entry name" value="I[[H]] CHANNEL, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45689:SF7">
        <property type="entry name" value="POTASSIUM_SODIUM HYPERPOLARIZATION-ACTIVATED CYCLIC NUCLEOTIDE-GATED CHANNEL 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08412">
        <property type="entry name" value="Ion_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01463">
        <property type="entry name" value="EAGCHANLFMLY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0114">cAMP</keyword>
    <keyword evidence="7" id="KW-0116">cAMP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="20" id="KW-0407">Ion channel</keyword>
    <keyword evidence="15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="19" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="16 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0630">Potassium</keyword>
    <keyword evidence="10" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="6" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0915">Sodium</keyword>
    <keyword evidence="4" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="18" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="8 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 24" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="11" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="188"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="419"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="25">
        <location>
            <begin position="522"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="750"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="913"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="23">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="756"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="783"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="822"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="834"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="913"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="23">
        <location>
            <begin position="956"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="980"/>
            <end position="993"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00036239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005017426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1014" mass="111365" checksum="927B9E33ACA346DF" modified="2022-01-19" version="1">MEWDWAMKRRLDRTEPGPNRDRDRTEPGPNRAGTGTETEPGPNRDRTGAGLNRLGGRMDPVPGRSTEHREKPAVMDGEAAGRGGTGTAIGAQDEASPVEQIVAEGETAAGTGTGTVTGTGTGTGTGTGTGTGTGTGTFVQRQFGAMLQPGVNKFSLRMFGSQKAVEIERQRVKSAGSWIIHPYSDFRFYWDLIMLLLMVGNLIIIPVGITFFKDENTTPWIVFNVVSDTFFLADLVLNFRTGIVVEDNTEIILDPRTIKMKYLKSWFVVDFISSIPVDYIFLVVDLETQVDSDVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLCHWDGCLQFLVPMLQDFPEDCWVSINHMVNDSWGKQYSHALFKSMSHMLCIGYGQQAPEGMSDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADMRQRIHDYYEHRYQGKMFDEESILGELSEPLKEEIINFNCRNLVANMPLFANADPNFVTAMLTKLRFEVFQPGDFIIREGTVGKKMYFIQHGVVSILTKGNKEMKLSDGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSILLRKRAEHSAGPINTEMIQQIVKHDQDVAHNIQELQQMTLGRELSGKPVIWEPLVHAPLQTAAATTNVAIALTHQHSLQAHIFLPPSSISSPLSPDTALLTKPVRRSQPSLGGSRPSSVSSPSGAPSHLQTPAAASPSSPMLQSQVPVESGAQRPSLGAQGPPRVGQKGEITTKQPPVAAVGPQPQLSKSRGASVSTSLLQQAAGAPSPSSEPPVGRTLHYSLSRATGSHISLLMQPQQLVKHRSIHGLPVGRLTQDVRLLSASQPSLPNKVAQQADGSGSLQQGRKSAGNLARRSSPSVSGLISKPAPGVPHPQPSGPPTQPNRPAAPSPQSPVSAPRPVAAPSRKGSVAFSPDVETGKPKLPSNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TVZ6</accession>
    <name>A0A8C2TVZ6_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">BK channel</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">KCNU1</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. KCa1.1/KCNMA1 sub-subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TVZ6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005025889.1">
        <property type="protein sequence ID" value="ENSCJPP00005018635.1"/>
        <property type="gene ID" value="ENSCJPG00005015158.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161817"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036126">
        <property type="term" value="C:sperm flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005267">
        <property type="term" value="F:potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000005">
        <property type="entry name" value="calcium-activated potassium channel subunit alpha-1 isoform X6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000130">
        <property type="entry name" value="Potassium calcium-activated channel subfamily U member 1"/>
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    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003929">
        <property type="entry name" value="K_chnl_BK_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047871">
        <property type="entry name" value="K_chnl_Slo-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048735">
        <property type="entry name" value="Slowpoke-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027">
        <property type="entry name" value="CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027:SF23">
        <property type="entry name" value="POTASSIUM CHANNEL SUBFAMILY U MEMBER 1"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF03493">
        <property type="entry name" value="BK_channel_a"/>
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    </dbReference>
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        <property type="entry name" value="Ion_trans"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF22614">
        <property type="entry name" value="Slo-like_RCK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21014">
        <property type="entry name" value="Slowpoke_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01449">
        <property type="entry name" value="BKCHANNELA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0630">Potassium</keyword>
    <keyword evidence="7" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="5" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="17">
        <location>
            <begin position="319"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008648"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
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        </source>
    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
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        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005018635.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1012" mass="114706" checksum="614622DF1EB24371" modified="2022-01-19" version="1">MAESELSCALHFQLAFISPSLFVFLGGLLTILAFRLIRCICRFILKKIWRKKVKNKDVWRSRKRKQRLVYYVRIFSTQMEMMLSAQTYMGRVLMTLVFFLNIGTLVIYFIDIVEAEQLHFSFPHRLIYVDQFCNAFFVFYFGLRFVAADDKLRFWLELNSLVDFFTIPPVFVAALLKKNCFGLRSLRALRLLDLPRILQILRITKDDNSIKLSKLFAVFISTLFTAAGLVHLVENNGDPWVQPVNSQTIPYFRCMYLIMVTMSTVGYGDIVVQTVLGRAFIFFFIIGGLVLFANVIPEVLEVVQSRKSYKSSYEVMSGKNYIVACGNVTLKSVTTFLEDFLLQYKGNVCTEILFLGESLPSLELEAVFKCYSPYTTFFYGSALNSEDLKRVRMESANACLILADVCSPEPYAEDISNIMRVLSIKNHYPKTRVILQIIQSRNKAYLPNIPNWDWRMGDSIICFAELKLGFMAQSCLVPGLSTLLTSLFIGKENTETKRKHLKDKMLLGDKDYKVMALQLSNDFADMTFIEVCRLCFVKLNLILLGIELKFGSRGESAILINPSPQIKLHRNTMGFFIAHSLAEVKRAQFYCRVCHSDIQDPEQIEKCQCGSKSHSKTFSEKLKISIESLILDGEPAKSRVPHAQEKKSSSLPLYLTGRFHCCDAVPLHEALLSCKNQAVLYLQDHILVCVFGDAKSPLIGLQDFVMPLRATNFLYRELKDIVLLGPLEYLQREWKFIQHFPKLWLFSGSALSCADLKAVNVQGCAACVILSSNTPISNNPSLADTESILATLNVRSMEAKLNSSSLDAVFGAGALGNQSEPRYKRIPITTELKFSPNAHFINQAPSSSSDNPDEDLLSSTAAPAGAIFSDSFFHSLLSMTYYNHHILALLHALVTSRTSPALEQLEEEDSRMSRSLDDMVQNPYHVRCKLALLPLSKRWLPGVMQEDSFGDIYCKALDTFGILCFGLYRLMDEPNPYKNRFVIPRPANDLKMLPTDLLFSIVPFNIAITEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TW75</accession>
    <name>A0A8C2TW75_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Catenin delta 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">CTNND2</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the beta-catenin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TW75"/>
    <dbReference type="Ensembl" id="ENSCJPT00005025561.1">
        <property type="protein sequence ID" value="ENSCJPP00005018341.1"/>
        <property type="gene ID" value="ENSCJPG00005014946.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154952"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043204">
        <property type="term" value="C:perikaryon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060997">
        <property type="term" value="P:dendritic spine morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060828">
        <property type="term" value="P:regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:001123">
        <property type="entry name" value="Catenin (cadherin-associated protein), delta 2a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:001160">
        <property type="entry name" value="Catenin delta 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028435">
        <property type="entry name" value="Plakophilin/d_Catenin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10372:SF9">
        <property type="entry name" value="CATENIN DELTA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10372">
        <property type="entry name" value="PLAKOPHILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="5" id="KW-0965">Cell junction</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="381"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="425"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="681"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="243"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="303"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="830"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="873"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="958"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1003"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="259"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="834"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="881"/>
            <end position="899"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005018341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1094" mass="120320" checksum="D9EDDD5495FBFA59" modified="2022-01-19" version="1">MLGRKQAGAALIEAMPVPDQPSSSDKTSSLSPVLNTSNGDGSETETTSAILASVKEQELQFERLTRELEAERQIVASQLERCKLGSETGSMSSISSTEEQFHWQTQDGQKDIEDELTTGLELVDSCIRSLQESGILDPQDYSASERPSLLSQSALQLNTKPEGSFQYSASYHSNQTLALGETAAAPLPARSTQPRGAIQSYSQLSSTIGTYATLSPTKRLVHAAEQYSKHSQELYATATLQRPGSLAAPSSPGVDSVPLQRTGSQHGTQNATATFQRASYAAGPASNYADPYRQLQYCPSVESPYSKSGPAIPPEGTLARSPSIDSIQKDPREFGWRDPELPEVIQMLQHQFPSVQSNAAAYLQHLCFGDNKIKAEIRRQGGIQLLVDLLDHRMTEVHRSACGALRNLVYGKANDDNKIALKNCGGIPALVRLLRKTTDLEIRELVTGVLWNLSSCDALKMPIIQDALAVLTNAVIIPHSGWENSPLQDDHKIQLHSSQVLRNATGCLRNVSSAGEEARRRMRECDGLTDALLYVIQSALGSSEIDSKTVENCVCILRNLSYRLAAETSQGQQMGTDELDGLLCGDANGKDAESSGCWGKKKKKKKSQDQWDGVGPLPDCAEPPKGIQMLWHPSIVKPYLTLLSECSNPDTLEGAAGALQNLAAGSWKWSVYIRAAVRKEKGLPILVELLRIDNDRVVCAVATALRNMALDVRNKELIGKYAMRDLVHRLPGANNSNSSASKAMSDDTVTAICCTLHEVITKNMENAKALRDAGGIEKLVGISKSKGDKHSPKVVKAASQVLNSMWQYRDLRSLYKKWAAPSFSVAEDRGFSPTHHSGSWHAQHTLSQSQETRIYSPSQDGWSQYHFVASSSTIERDRQRPYSSSRTPSISPVRMSPNNRSVANVNQEMERSEYEDILSGLQLFNSETSEKRCAPSLQTSSAPASPREMISLKERKTDYESTGTNATYHGSKGEHTSRKDTMTAQNTGISTLYRNSYGAPAEDIKHNQVSTQPVPQEPSRKDYEPYQPFQNSTRNYDESFFEDQVHHRPPTSEYNMHLGLKSTGNYVDFYSAARPYSELNYETSHYPASPDSWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TWB8</accession>
    <name>A0A8C2TWB8_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TWB8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005027108.1">
        <property type="protein sequence ID" value="ENSCJPP00005019591.1"/>
        <property type="gene ID" value="ENSCJPG00005015868.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00960000189973"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005019591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="156" mass="17137" checksum="957DDDEDA5B363BE" modified="2022-01-19" version="1">MFGLCFCRKQEIECITNPKDGEFLLCQQKEPASSLWASLFDGSHEMVVQKNLHAASANDGRGKKRRAPPPPSDKPAYNAEARGNTEELDKENWERPDGTAGSSFHSALPTETQQLQAPSAAPRKICPCRKNSLTESETKPVPTPRQKCTTEALDPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TWQ2</accession>
    <name>A0A8C2TWQ2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tripeptidyl-peptidase 2</fullName>
            <ecNumber evidence="5">3.4.14.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Tripeptidyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">TPP2</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Cytosolic tripeptidyl-peptidase that releases N-terminal tripeptides from polypeptides and is a component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. It plays an important role in intracellular amino acid homeostasis. Stimulates adipogenesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal tripeptide from a polypeptide.</text>
            <dbReference type="EC" id="3.4.14.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.10" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2TWQ2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005027348.1">
        <property type="protein sequence ID" value="ENSCJPP00005019771.1"/>
        <property type="gene ID" value="ENSCJPG00005016001.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000014623"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04857">
        <property type="entry name" value="Peptidases_S8_Tripeptidyl_Aminopeptidase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.710:FF:000001">
        <property type="entry name" value="Tripeptidyl peptidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.3170:FF:000001">
        <property type="entry name" value="Tripeptidyl peptidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000003">
        <property type="entry name" value="Tripeptidyl peptidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034051">
        <property type="entry name" value="TPP_II_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022232">
        <property type="entry name" value="TPPII_C_art"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046939">
        <property type="entry name" value="TPPII_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048384">
        <property type="entry name" value="TPPII_GBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048383">
        <property type="entry name" value="TPPII_Ig-like-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022229">
        <property type="entry name" value="TPPII_Ig-like-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046940">
        <property type="entry name" value="TPPII_Ig-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF14">
        <property type="entry name" value="TRIPEPTIDYL-PEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12580">
        <property type="entry name" value="TPPII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12583">
        <property type="entry name" value="TPPII_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21316">
        <property type="entry name" value="TPPII_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21223">
        <property type="entry name" value="TPPII_Ig-like-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-0645">Protease</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S8/S53" evidence="19">
        <location>
            <begin position="148"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Tripeptidyl-peptidase II first Ig-like" evidence="22">
        <location>
            <begin position="432"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="Tripeptidyl-peptidase II galactose-binding" evidence="23">
        <location>
            <begin position="565"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="domain" description="Tripeptidyl peptidase II second Ig-like" evidence="20">
        <location>
            <begin position="689"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="domain" description="Tripeptidyl peptidase II C-terminal" evidence="21">
        <location>
            <begin position="934"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="918"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="927"/>
            <end position="942"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00054482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF12580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF12583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF21223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF21316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005019771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1173" mass="130541" checksum="0587FBC0CAE68092" modified="2022-01-19" version="1">MGLSGRTLKIPANWVNPSGKYHIGIKNGYDIYPKALKERIQKERKEKLWDPLHRLALAEACRKQEEFDAAHSSPSQVNKLIKEELQNQVELLNSFEKKYSDPGPVYDCLVWHDGETWRACIDTSESGDLTGCTVLRTYKEAQEYGSFGTSEMLNYSVNIYDDGNLLSIVTSGGAHGTHVASIAAGYFPEEPERNGVAPGAQILAIKIGDTRLSTMETGTGLIRAMIEAIKYKCDLVNYSYGEATHWPNSGRICEVINEAVWKHNVIYVSSAGNNGPCLSTVGCPGGTTSSVIGVGAYVSPDMMVAEYSLREKLPANQYTWSSRGPSTDGALGVSISAPGGAIASVPNWTLRGTQLMNGTSMSSPNACGGIALVLSGLKANNIHYTVHSVRRALENTAVKAENIEVFAQGHGVIQVDKAYDYLIQNSSFTSNIGFTITVGSNRGIYLRDPVQISAPSDHGVGIEPVFPENTENTERISLQLHLALTSNAPWVQCPSHLELMNQCRHINVRVDPRGLREGVHYTEVCGYDIATPNAGPLFRVPITVVIPTRVDESSSYDLAYTDVHFKPGQIRRHFIDVPQGATWAEVTISSCSSDVTAKFVLHAVQLVKQKAYRSHEFYKFLSLPEKGSVTEAFPVLAGKTIEFCVARWWASLSDVSINYTVSFHGVLCATPQLNMHASEGIVRFDVQSMLKYEDIAPCINLKSWIQTLRPVSAKIKPLGSRDILPNNRQLYEMILTYNFHQPKSGEVTPSCPLLCELLYESEFDSQLWIIFDQNKRQMGSGDAYPHQYSVKLEKGDYTIRLQIRHEQNSELDRIKDLPFIVSHRLSSTLSLDIYENHSLALLGKKKSNSLTLPPKHSQPFFVTSLPDDKIPKGAGPGCYLAGALTLSKTELGKKAGQSAAKRQGKFKKDVLTVHYHLIPSPSKSKNGSKEKEREQEKEKDVKEEFAEALRDLKIQWMTKLDTPDVYNELKEAFPNHLPLYVARLHQLDSEKERMKRLDEIVEAANTVISHIDQTALAVYFAMKTDPRPDATTIKNEMEKQKTTLVDALCRKGSALADQLLHLQTQDGAASSDAEGKDEDHESCSEALTETFWETTKWTDLFDSKVLTFAYKHALVNKMYGRGLKFATKLAEEKPTKDNLKNCIQLMKLLGWTHCATFSENWLPVMYPPDYCVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TWT2</accession>
    <name>A0A8C2TWT2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">14 kDa phosphohistidine phosphatase</fullName>
            <ecNumber evidence="5">3.9.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Phosphohistidine phosphatase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Protein histidine phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">PHPT1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Exhibits phosphohistidine phosphatase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(pros)-phospho-L-histidyl-[protein] + H2O = L-histidyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47964"/>
            <dbReference type="Rhea" id="RHEA-COMP:9745"/>
            <dbReference type="Rhea" id="RHEA-COMP:9746"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64837"/>
            <dbReference type="EC" id="3.9.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(tele)-phospho-L-histidyl-[protein] + H2O = L-histidyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47960"/>
            <dbReference type="Rhea" id="RHEA-COMP:9745"/>
            <dbReference type="Rhea" id="RHEA-COMP:10719"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83586"/>
            <dbReference type="EC" id="3.9.1.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the janus family.</text>
    </comment>
    <dbReference type="EC" id="3.9.1.3" evidence="5"/>
    <dbReference type="RefSeq" id="XP_015734190.1">
        <property type="nucleotide sequence ID" value="XM_015878704.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TWT2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005027020.1">
        <property type="protein sequence ID" value="ENSCJPP00005019517.1"/>
        <property type="gene ID" value="ENSCJPG00005015811.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107321627"/>
    <dbReference type="KEGG" id="cjo:107321627"/>
    <dbReference type="CTD" id="29085"/>
    <dbReference type="GeneTree" id="ENSGT00390000002738"/>
    <dbReference type="OrthoDB" id="10249612at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061851">
        <property type="term" value="C:leading edge of lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019855">
        <property type="term" value="F:calcium channel inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004857">
        <property type="term" value="F:enzyme inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101006">
        <property type="term" value="F:protein histidine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044325">
        <property type="term" value="F:transmembrane transporter binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097581">
        <property type="term" value="P:lamellipodium organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050860">
        <property type="term" value="P:negative regulation of T cell receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000147">
        <property type="term" value="P:positive regulation of cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.20.20:FF:000001">
        <property type="entry name" value="14 kDa phosphohistidine phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.20.20">
        <property type="entry name" value="Janus/Ocnus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007702">
        <property type="entry name" value="Janus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038596">
        <property type="entry name" value="Janus_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12258:SF10">
        <property type="entry name" value="14 KDA PHOSPHOHISTIDINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12258">
        <property type="entry name" value="JANUS-A/JANUS-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05005">
        <property type="entry name" value="Ocnus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143724">
        <property type="entry name" value="PHP14-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR607702-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR607702-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005019517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="120" mass="13283" checksum="90EB8A08C0FE8266" modified="2022-01-19" version="1">MAAALQRVPDVEIDAGGVFKYVLLRVRPRGDAGTGKDVVRGHGWAEYHADIYDRAAAELEPQGLDCECLGGGRISHRSQEKKIHVYGYSVGFGRANHSVTTEKLKAKYPDYEITWADEGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TXS7</accession>
    <name>A0A8C2TXS7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">U3 small nucleolar RNA-associated protein 11</fullName>
            <shortName evidence="5">U3 snoRNA-associated protein 11</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">UTP11</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the ribosomal small subunit (SSU) processome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
            <location evidence="1 5">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the UTP11 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015739148.1">
        <property type="nucleotide sequence ID" value="XM_015883662.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TXS7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005027981.1">
        <property type="protein sequence ID" value="ENSCJPP00005020289.1"/>
        <property type="gene ID" value="ENSCJPG00005016361.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107324012"/>
    <dbReference type="KEGG" id="cjo:107324012"/>
    <dbReference type="CTD" id="51118"/>
    <dbReference type="GeneTree" id="ENSGT00390000005813"/>
    <dbReference type="OrthoDB" id="29058at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007144">
        <property type="entry name" value="SSU_processome_Utp11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12838">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12838:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03998">
        <property type="entry name" value="Utp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015952">
        <property type="entry name" value="U3snoRNP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR015952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005020289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="253" mass="30098" checksum="8F1F330C0D3CDA60" modified="2022-01-19" version="1">MSAAFRKAAKSGQRQHRERGQPASRKKLGLLEKKQDYRLRAQDYHKKHNALRALQKKALDKNPDEFYFKMIRTQLKDGVHVIKQPKDEVTPEQMKLMKTQDLKYVEMKRVAEAKKIERLKSELHLLDVEGKQPNKHTFFFDTKKEVREFDIATHLNTVPELVDRVYNRPTIATLQKETLKGATDPAHLKKLDQQRKNQYDLLKQRIEREKSMFVIAQKIQTRKDLLDKTHKVKVKKETVNNPAIYRFKFQRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TXX0</accession>
    <name>A0A8C2TXX0_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ANKH inorganic pyrophosphate transport regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ANKH</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ANKH family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TXX0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005026439.1">
        <property type="protein sequence ID" value="ENSCJPP00005019074.1"/>
        <property type="gene ID" value="ENSCJPG00005015490.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000012189"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005347">
        <property type="term" value="F:ATP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030504">
        <property type="term" value="F:inorganic diphosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904669">
        <property type="term" value="P:ATP export"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009887">
        <property type="entry name" value="ANKH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28384">
        <property type="entry name" value="PROGRESSIVE ANKYLOSIS PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28384:SF1">
        <property type="entry name" value="PROGRESSIVE ANKYLOSIS PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07260">
        <property type="entry name" value="ANKH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="398"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="433"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="460"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005019074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="479" mass="52786" checksum="608F22EF87F51ECA" modified="2022-01-19" version="1">MVKFPALTNYWPLIRFLVPLGITNIAIDFGEQALNRGIAAVKEDAVEMLASYGLAYSLMKFFTGPMSDFKNVGLVFVNSKRDRTKAVLCMVVAGAVAAIFHTLIAYSDLGYYIINKLHHVDESVGSKTRRAFLYLAAFPFMDAMAWTHAGILLKHKYSFLVGCASISDVIAQVVFVAILLHSHLECREPLLIPILSLYMGALVRCTTLCLGYYRNIHDVIPDRSGPEMGGEATIRKMLSFWWPLALILATQRISRPIVNLFVSRDLGGSSSATEAVAILTATYPVGHMPYGWLTEIRAVYPAFDKNNPSNKLVNTNSTVTSTHIKKFTFVCMALSLTLCFVMFWTPNVSEKILVDIIGVDFAFAELCVVPLRIFSFFPVPVTVRAHLTGWLMTLKKTFVLAPSSVLRIIVLITSLIVLPYLGVHGATLGVGSLLAGFVGESTMVAIAACYVYRKQKKKRNENETSGEGKDLEIRSSAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TY55</accession>
    <name>A0A8C2TY55_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Acid sphingomyelinase-like phosphodiesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="primary">SMPDL3B</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="27" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="27" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="21">Lipid-modulating phosphodiesterase. Active on the surface of macrophages and dendritic cells and strongly influences macrophage lipid composition and membrane fluidity. Acts as a negative regulator of Toll-like receptor signaling. Has in vitro phosphodiesterase activity, but the physiological substrate is unknown. Lacks activity with phosphocholine-containing lipids, but can cleave CDP-choline, and can release phosphate from ATP and ADP (in vitro).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="24">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="24">Binds 2 Zn(2+) per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="22">Interacts with TLR4, TLR7, TLR8 and TLR9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 23">Belongs to the acid sphingomyelinase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015738978.1">
        <property type="nucleotide sequence ID" value="XM_015883492.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TY55"/>
    <dbReference type="Ensembl" id="ENSCJPT00005026573.1">
        <property type="protein sequence ID" value="ENSCJPP00005019143.1"/>
        <property type="gene ID" value="ENSCJPG00005015568.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107323927"/>
    <dbReference type="KEGG" id="cjo:107323927"/>
    <dbReference type="CTD" id="27293"/>
    <dbReference type="GeneTree" id="ENSGT00950000183182"/>
    <dbReference type="OrthoDB" id="348678at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004767">
        <property type="term" value="F:sphingomyelin phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050728">
        <property type="term" value="P:negative regulation of inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034122">
        <property type="term" value="P:negative regulation of toll-like receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006685">
        <property type="term" value="P:sphingomyelin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00842">
        <property type="entry name" value="MPP_ASMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000057">
        <property type="entry name" value="Acid sphingomyelinase-like phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017064">
        <property type="entry name" value="ASM-like_Pdiesterase_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045473">
        <property type="entry name" value="ASM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041805">
        <property type="entry name" value="ASMase/PPN1_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340:SF25">
        <property type="entry name" value="ACID SPHINGOMYELINASE-LIKE PHOSPHODIESTERASE 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19272">
        <property type="entry name" value="ASMase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036767">
        <property type="entry name" value="ASM-like_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="20" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="10 23" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0391">Immunity</keyword>
    <keyword evidence="18" id="KW-0395">Inflammatory response</keyword>
    <keyword evidence="6" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="13" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="19" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 23 24" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 23" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 23" id="KW-0732">Signal</keyword>
    <keyword evidence="11 23 24" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034385704" description="Acid sphingomyelinase-like phosphodiesterase" evidence="23">
        <location>
            <begin position="23"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="25">
        <location>
            <begin position="24"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Sphingomyelin phosphodiesterase C-terminal" evidence="26">
        <location>
            <begin position="291"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008234"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023198"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00058717"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00063194"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRNR" id="PIRNR036767"/>
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    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR036767-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF19272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005019143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="457" mass="51442" checksum="63B9FFDA93DBA9EC" modified="2022-01-19" version="1">MMEAVTVRAAALLVLLQPAVMAGTFWHLTDLHWDPGYEEALSAGQRCPSGGSGPGGPWGSYECDAPWALLSSAVSAMKRLRARPDFVLWTGDDTPHVPDEQLGEEKVLHIIANLTSLIKQVFPDTKVFAAMGNHDFHPKNQFPGKENRIYNQTAELWRSWLNEASIPLFRAGAFYSEKLPSPNTRGRMIVLNTNLYYDQNSQTAGEEDPGGQFQWLEETLTNASKAEEMVYIVGHVPPGFFEKKRGKPWFRRDFNERYLNIVQKHHGVIAAQFFGHHHTDSFRMFYSDTGSPINVMFLAPGVTPWKTTLPGVTNGANNPGIRVVDYDADTLQVQDMVTYYLNLTRANLLGPVWEEEYRLSSAFQVPDGSTQSMQTVLDRISEDAKYLQRYYEFNSVRYDLTPCGETCRVDHVCAIKEIDFSRYEQCLEANSSTSAISSICLLFLSLLLGIFGPQQTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TZP9</accession>
    <name>A0A8C2TZP9_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FERRY endosomal RAB5 effector complex subunit 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FERRY3</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TZP9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005027740.1">
        <property type="protein sequence ID" value="ENSCJPP00005020086.1"/>
        <property type="gene ID" value="ENSCJPG00005016222.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107317974"/>
    <dbReference type="KEGG" id="cjo:107317974"/>
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    <dbReference type="GeneTree" id="ENSGT00390000010229"/>
    <dbReference type="OrthoDB" id="415359at2759"/>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043304">
        <property type="term" value="P:regulation of mast cell degranulation"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019311">
        <property type="entry name" value="Fy-3"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN C12ORF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16525:SF0">
        <property type="entry name" value="PROTEIN C12ORF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10154">
        <property type="entry name" value="Fy-3"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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            <dbReference type="Ensembl" id="ENSCJPP00005020086.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="550" mass="63189" checksum="B4B2E308A08218EC" modified="2022-01-19" version="1">MKPNRGRTCAGEKDYVYTLNAGNQHFVLTVPLKFPVQENVSHLHGRLMLLHNLPCFVENDLRESLNKFIEDETIKGYDREAEMALEAVKSGEVDINQLADTWAKAYKETTLEYAKPEENSWDEDFADVYHDLIHSPASETLLNLEHNYFVSISELISERDVELKKLQERQGAEMDKVMQELGKSLTDQDVNSLAARHFESQQDLENKWTNELKQSTAIQKQEYQEWVIKLHQDLKNPNNSSISDEIKVQPSQLRESVEGNGRIYEEQRLLEESFTIHLGAQLKTMHNLRLLRADMLDFCKHKRNHRNGVKLHRLQTAMSLYSTSLCGLVLLVDNRISSYSGIKRDFATVCQECTDFHFPGIQEQLEIVQKVVLKARAQRSNKSKKHHGNKGSGIEDKSKNIERNQSNILQGEFYITRHSNLSEIHVAFHLCVDDNVRSGNITARDPAIMGLRNILKVCCTHDITTISIPLLLVHDMSEEMTIPWCLKRAELVFKCVKGFMMEMASWDGGVSRTVQFLVPQTISEELFYQLSNMLPQIFRVSSTLTLTSKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U1X4</accession>
    <name>A0A8C2U1X4_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Shisa like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">SHISAL1</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
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            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_032302320.1">
        <property type="nucleotide sequence ID" value="XM_032446429.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032302327.1">
        <property type="nucleotide sequence ID" value="XM_032446436.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032302332.1">
        <property type="nucleotide sequence ID" value="XM_032446441.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032302333.1">
        <property type="nucleotide sequence ID" value="XM_032446442.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032302335.1">
        <property type="nucleotide sequence ID" value="XM_032446444.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032302337.1">
        <property type="nucleotide sequence ID" value="XM_032446446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U1X4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005027562.1">
        <property type="protein sequence ID" value="ENSCJPP00005019945.1"/>
        <property type="gene ID" value="ENSCJPG00005016124.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005027563.1">
        <property type="protein sequence ID" value="ENSCJPP00005019946.1"/>
        <property type="gene ID" value="ENSCJPG00005016124.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107317417"/>
    <dbReference type="CTD" id="85352"/>
    <dbReference type="GeneTree" id="ENSGT00390000006791"/>
    <dbReference type="OrthoDB" id="9941515at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026910">
        <property type="entry name" value="Shisa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053891">
        <property type="entry name" value="Shisa_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31395:SF11">
        <property type="entry name" value="PROTEIN SHISA-LIKE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31395">
        <property type="entry name" value="SHISA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13908">
        <property type="entry name" value="Shisa_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044679403" evidence="7">
        <location>
            <begin position="26"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Shisa N-terminal" evidence="8">
        <location>
            <begin position="30"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="153"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005019945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="219" mass="24909" checksum="B4013EF9A03F3098" modified="2022-01-19" version="1">MTSCGQQSLNVLMVLLSLLLSAVLSAHFRVCEPYTDYKGRYHFGFHCPRLSDNKSYIFCCHHNNTVFKYCCNETEFQTVMQMNLTGNADGYMHNNYSALLGVWIYGFFVVILLILDLLYYSSMNYDICKFYLARWGIQGKWMTQGQSRWINSAQDPSQVQTQPQPETQPQTQPQPQPQTSQTVHTLKGDALSPPLMSFQSTSACDRTGTQVPVRSPSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U446</accession>
    <name>A0A8C2U446_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cofilin 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">CFL2</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin-binding proteins ADF family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2U446"/>
    <dbReference type="SMR" id="A0A8C2U446"/>
    <dbReference type="Ensembl" id="ENSCJPT00005030183.1">
        <property type="protein sequence ID" value="ENSCJPP00005022007.1"/>
        <property type="gene ID" value="ENSCJPG00005017583.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183000"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030043">
        <property type="term" value="P:actin filament fragmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046716">
        <property type="term" value="P:muscle cell cellular homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030836">
        <property type="term" value="P:positive regulation of actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045214">
        <property type="term" value="P:sarcomere organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007519">
        <property type="term" value="P:skeletal muscle tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd11286">
        <property type="entry name" value="ADF_cofilin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000010">
        <property type="entry name" value="Putative destrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017904">
        <property type="entry name" value="ADF/Cofilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11913">
        <property type="entry name" value="COFILIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00006">
        <property type="entry name" value="COFILIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="3">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005022007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="149" mass="16842" checksum="397CEA80AE1CA544" modified="2022-01-19" version="1">MKVRKSSTPEEIKKRKKAVLFCLSDDKKQIIVEEAKQILVGDIGDTVEDPYTAFVKLLPLNDCRYALYDATYETKESKKEDLVFIFWAPESAPLKSKMIYASSKDAIKKKFTGIKHEWQVNGLDDIKDRSTLGEKLGGNVVVSLEGKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U471</accession>
    <name>A0A8C2U471_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="27">Mitogen-activated protein kinase kinase kinase 20</fullName>
            <ecNumber evidence="5">2.7.11.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="31">Leucine zipper- and sterile alpha motif-containing kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="28">MLK-like mitogen-activated protein triple kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="30">Mitogen-activated protein kinase kinase kinase MLT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="29">Mixed lineage kinase-related kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="32">Sterile alpha motif- and leucine zipper-containing kinase AZK</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="37" type="primary">MAP3K20</name>
    </gene>
    <organism evidence="37 38">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="37" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="37" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="37" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="22">Isoform that lacks the C-terminal region that mediates ribosome-binding: does not act as a sensor of ribosome collisions in response to ribotoxic stress. May act as an antagonist of isoform ZAKalpha: interacts with isoform ZAKalpha, leading to decrease the expression of isoform ZAKalpha.</text>
    </comment>
    <comment type="function">
        <text evidence="23">Stress-activated component of a protein kinase signal transduction cascade that promotes programmed cell death in response to various stress, such as ribosomal stress, osmotic shock and ionizing radiation. Acts by catalyzing phosphorylation of MAP kinase kinases, leading to activation of the JNK (MAPK8/JNK1, MAPK9/JNK2 and/or MAPK10/JNK3) and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways. Activates JNK through phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7, and MAP kinase p38 gamma (MAPK12) via phosphorylation of MAP2K3/MKK3 and MAP2K6/MKK6. Involved in stress associated with adrenergic stimulation: contributes to cardiac decompensation during periods of acute cardiac stress. May be involved in regulation of S and G2 cell cycle checkpoint by mediating phosphorylation of CHEK2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="26">Homodimer. Interacts with ZNF33A. Component of a signaling complex containing at least AKAP13, PKN1, MAPK14, MAP3K20 and MAP2K3. Within this complex, AKAP13 interacts directly with PKN1, which in turn recruits MAPK14, MAP2K3 and MAP3K20. Interacts with EIF2AK4/GCN2; promoting EIF2AK4/GCN2 kinase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="25">Interacts with isoform ZAKalpha.</text>
    </comment>
    <comment type="subunit">
        <text evidence="24">Interacts with isoform ZAKbeta.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.25" evidence="5"/>
    <dbReference type="RefSeq" id="XP_015723972.1">
        <property type="nucleotide sequence ID" value="XM_015868486.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U471"/>
    <dbReference type="Ensembl" id="ENSCJPT00005030512.1">
        <property type="protein sequence ID" value="ENSCJPP00005022226.1"/>
        <property type="gene ID" value="ENSCJPG00005017760.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107316691"/>
    <dbReference type="KEGG" id="cjo:107316691"/>
    <dbReference type="CTD" id="51776"/>
    <dbReference type="GeneTree" id="ENSGT00940000161352"/>
    <dbReference type="OrthoDB" id="339325at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004706">
        <property type="term" value="F:JUN kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071480">
        <property type="term" value="P:cellular response to gamma radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071493">
        <property type="term" value="P:cellular response to UV-B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042733">
        <property type="term" value="P:embryonic digit morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140469">
        <property type="term" value="P:GCN2-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007254">
        <property type="term" value="P:JNK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038066">
        <property type="term" value="P:p38MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904291">
        <property type="term" value="P:positive regulation of mitotic DNA damage checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070269">
        <property type="term" value="P:pyroptotic inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051403">
        <property type="term" value="P:stress-activated MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd09529">
        <property type="entry name" value="SAM_MLTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14060">
        <property type="entry name" value="STKc_MLTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000065">
        <property type="entry name" value="mitogen-activated protein kinase kinase kinase 20 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000220">
        <property type="entry name" value="mitogen-activated protein kinase kinase kinase 20 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000243">
        <property type="entry name" value="mitogen-activated protein kinase kinase kinase 20 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF288">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0007">Acetylation</keyword>
    <keyword evidence="14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="19" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="33" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="38" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="11" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="35">
        <location>
            <begin position="16"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="36">
        <location>
            <begin position="339"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="34">
        <location>
            <begin position="651"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="33">
        <location>
            <begin position="280"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="34">
        <location>
            <begin position="657"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="34">
        <location>
            <begin position="681"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="34">
        <location>
            <begin position="743"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="34">
        <location>
            <begin position="763"/>
            <end position="772"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00050818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00051073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00056730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00058083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00062065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00063590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00063807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00069021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00075506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00078648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00080027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00080956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00083422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="35">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="36">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="37">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005022226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="38">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="791" mass="89644" checksum="7EEB8F8B78CF9E0A" modified="2022-01-19" version="1">MSSSSASFVQIRFDDLQFFENCGGGSFGSVYRARWISQDKEVAVKKLLKIEKEAEILSVLSHKNIIQFYGAVIEPPNYGIVTEYASAGSLFDYINSNKSEEMDMDHIMTWATDIAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHSHTTHMSLVGTFPWMAPEVIQSLPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELMHQCWEADSKKRPSFKQIISILESMSNDSNLPDQCNSFLHNKAEWRCEIEATLERLKKLERDLSFKEQELKERERRLKMWEQKLTEQSNTPLLPSFDICAWTEEDVFFWMQQLTRKGDASGEMSAYASLFKEHHITGKRLLLLEEEDLKDMGIVSRGHIIHLKTAIEKLTHDYLNLFHFPPLIKDSVGEAGENVEKVVNLELVFGYHLKLGNGPKDCKWKMYMEMDGDEIAITYIKDVTFNTNLPDVEILKMTKPPFVMEKWIVGIEEHQSVECIVTYESDVRAPKSTRHVQAICWSKVKAQDEVKAVQLMIQTSLPNSEGHSRSRSDSSIDSQWMQTLRMHQIAKAISLQHGHPHNPTTISHYLPYLQSQDSYAAAVRRTRGPVSYHYTSISHSRNSSPFSHSLVRTLSNLHLNSKGSSTSSTASDTASERDRSTGKARNASHSGNSRSSSDGRRSGTSSPVPPRSSGRAGRTASMPPAHEQRRYTRNSPQPKAIPGMPLQGESEPKRSEGEGRVSEGGWIKVQHVKKPHRQSTGKQGKERPKGSWRGRRTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U7K9</accession>
    <name>A0A8C2U7K9_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Protein kinase cAMP-dependent X-linked catalytic subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">PRKX</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015704274.1">
        <property type="nucleotide sequence ID" value="XM_015848788.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U7K9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005031457.1">
        <property type="protein sequence ID" value="ENSCJPP00005022952.1"/>
        <property type="gene ID" value="ENSCJPG00005018237.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107306025"/>
    <dbReference type="KEGG" id="cjo:107306025"/>
    <dbReference type="CTD" id="5613"/>
    <dbReference type="GeneTree" id="ENSGT00940000159832"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001525">
        <property type="term" value="P:angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031589">
        <property type="term" value="P:cell-substrate adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043542">
        <property type="term" value="P:endothelial cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001935">
        <property type="term" value="P:endothelial cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060562">
        <property type="term" value="P:epithelial tube morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060993">
        <property type="term" value="P:kidney morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030099">
        <property type="term" value="P:myeloid cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030155">
        <property type="term" value="P:regulation of cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030334">
        <property type="term" value="P:regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000696">
        <property type="term" value="P:regulation of epithelial cell differentiation involved in kidney development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd05612">
        <property type="entry name" value="STKc_PRKX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF37">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="56"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="11">
        <location>
            <begin position="311"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="18"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005022952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="365" mass="41341" checksum="2F6C927D98974390" modified="2022-01-19" version="1">MDAFSAAKAKMGAKSGGEAAAAAGLAAPQPAATAPSPSGPGSPSAPEPAAYKLEDLETLATVGTGTFGRVHLVKEKMGKHYFALKVMSIPDVIRLKQEQHVHNEKSVLKEVNHPFLIRLFWTYHDERFLYMLMEYVPGGELFSYLRNMGRFNNSTGLFYSTEIICAIEYLHSKEIVYRDLKPENILLDKEGHIKLTDFGFAKKLVDRTWTLCGTPEYLAPEVIQSKGHGRAVDWWALGILIFEMLSGFPPFFDDNPFGIYQKILAGKIDFPRHLDLYVKDLIKKLLVVDRTRRLGNMKNGADDVKRHRWFRSIEWDAVPQRRLKPPIVPKVSNDGDTSNFEAYPEDDWNKMPPVPPKDLEIFKNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U7S5</accession>
    <name>A0A8C2U7S5_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">nucleoside-triphosphate phosphatase</fullName>
            <ecNumber evidence="3">3.6.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ENTPD7</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the GDA1/CD39 NTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.15" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2U7S5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005033799.1">
        <property type="protein sequence ID" value="ENSCJPP00005024815.1"/>
        <property type="gene ID" value="ENSCJPG00005019527.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286963"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043273">
        <property type="term" value="F:CTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004382">
        <property type="term" value="F:GDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045134">
        <property type="term" value="F:UDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006254">
        <property type="term" value="P:CTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046039">
        <property type="term" value="P:GTP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034656">
        <property type="term" value="P:nucleobase-containing small molecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050776">
        <property type="term" value="P:regulation of immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072539">
        <property type="term" value="P:T-helper 17 cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006256">
        <property type="term" value="P:UDP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046052">
        <property type="term" value="P:UTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd24045">
        <property type="entry name" value="ASKHA_NBD_NTPDase4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000057">
        <property type="entry name" value="Ectonucleoside triphosphate diphosphohydrolase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.150:FF:000003">
        <property type="entry name" value="ectonucleoside triphosphate diphosphohydrolase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000407">
        <property type="entry name" value="GDA1_CD39_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782">
        <property type="entry name" value="ADENOSINE/GUANOSINE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782:SF37">
        <property type="entry name" value="ECTONUCLEOSIDE TRIPHOSPHATE DIPHOSPHOHYDROLASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01150">
        <property type="entry name" value="GDA1_CD39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01238">
        <property type="entry name" value="GDA1_CD39_NTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="554"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="263"/>
            <end position="267"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005024815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="601" mass="67268" checksum="00299BD0FC5A8DAD" modified="2022-01-19" version="1">MARIAAPCPPCRSAVSCGFPVPRQRPALLGLSVAAGLLLLLLLAGPRRWASPPRDGRRNERYVARMEELAATDTEDPSLSYGVVVDCGSSGSRVFVYVWPPHNGHPHDLLDIRQMRDRGSRPVVMKVKPGISAAAATPERATAYLRPLLRYAAAHVPAGKHKETPLYVLCTAGMRLLPDRLQAAILENLVKNVPLEFDFLFSESHAEVISGKQEGVYAWIGINFVLGRFDHEDEEAAVVTVALGDQVESLVRKRTVGILDMGGASLQIAYEVPGSGAFSSPQQEEAAKSLLAEFNLGCDVQHTGHVYRVYVNTFLGFGGNFARQRYEELVLNQTYAHNRLHSQKTGLSPETPFLDPCLPVGLEDTVTRGSKTLYVRGRGDWQACALLLHPLLAGSNSSQDSLTGAYKAPIDFSNSEFYGFSEFFYCTEDVLRLGGHYSARAFISAAQEYCSQSWEVLTQRFQSGLYSAHADEHRLKYQCFKSAWMYQVLHQGFHFPLDYPSLHTAQLVYDREVQWTLGAILYKTRFLPLRDLRQESSRQAHTSWLRLSFVYNHYLFFACILVVGLAIVLYLLRLRRIHRRQLDLLWLDKVVLLPPGQGDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U7S8</accession>
    <name>A0A8C2U7S8_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">RPL9</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015717974.1">
        <property type="nucleotide sequence ID" value="XM_015862488.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U7S8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005030671.1">
        <property type="protein sequence ID" value="ENSCJPP00005022383.1"/>
        <property type="gene ID" value="ENSCJPG00005017840.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107313824"/>
    <dbReference type="KEGG" id="cjo:107313824"/>
    <dbReference type="CTD" id="6133"/>
    <dbReference type="GeneTree" id="ENSGT00390000015224"/>
    <dbReference type="OrthoDB" id="10252633at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000003">
        <property type="entry name" value="60S ribosomal protein L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000005">
        <property type="entry name" value="60S ribosomal protein L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="entry name" value="Ribosomal protein L6, alpha-beta domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_uL6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_uL6-like_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_uL6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002359">
        <property type="entry name" value="Ribosomal_uL6_CS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF16">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="60S/50S RIBOSOMAL PROTEIN L6/L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002162">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="Ribosomal protein L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00700">
        <property type="entry name" value="RIBOSOMAL_L6_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="6">
        <location>
            <begin position="12"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="6">
        <location>
            <begin position="99"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005022383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="192" mass="21886" checksum="EE00C8F8D615EDDB" modified="2022-01-19" version="1">MKTILSNQTVEIPPKVTVSLKGRTVIVKGPRGTLRRDFNHINVELSLLGKKRRKLRVDKWWGNRKELATVRTICSHVQNMIKGVTLGFRYKMRSVYAHFPINVVIQENGSLVEIRNFLGEKYIRRVRMRPGVTCAVSQAQKDELILEGNDIELVSNSAALIQQATTVKNKDIRKFLDGIYVSEKGTVQQPDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U8B9</accession>
    <name>A0A8C2U8B9_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chromosome 3 open reading frame 33</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">C3orf33</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2U8B9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005031265.1">
        <property type="protein sequence ID" value="ENSCJPP00005022806.1"/>
        <property type="gene ID" value="ENSCJPG00005018129.1"/>
    </dbReference>
    <dbReference type="KEGG" id="cjo:107318410"/>
    <dbReference type="GeneTree" id="ENSGT00390000004493"/>
    <dbReference type="OrthoDB" id="6220511at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070373">
        <property type="term" value="P:negative regulation of ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.90:FF:000024">
        <property type="entry name" value="Chromosome 3 C3orf33 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042421">
        <property type="entry name" value="C3orf33-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28434">
        <property type="entry name" value="PROTEIN C3ORF33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28434:SF1">
        <property type="entry name" value="PROTEIN C3ORF33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="Staphylococcal nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005022806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="240" mass="27149" checksum="6B875337AA851B76" modified="2022-01-19" version="1">MAERRGGAAEGLARLSEWADAHLGLVRSLSAGVAVAGLLVLARSVRMTTKFTNALDVPAGFIQKNVKLRGKVHRVTEKGLEVEHIPISVPFITSIQRKWQSEGLLLVRLAGVELTPEGTEWIQRELKPSQVIWFQLLGREHLALECLVIVNKGRFSSVCLNEEVLREGLGRAASIEGLQHDSHLFWELHKRLLRAELKALRKNKGIWKEESFSERLRARMSSSNFMQTLKRFVSWLRSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U9R6</accession>
    <name>A0A8C2U9R6_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">RILP-like protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">RILPL2</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2U9R6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005034527.1">
        <property type="protein sequence ID" value="ENSCJPP00005025374.1"/>
        <property type="gene ID" value="ENSCJPG00005019925.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160182"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003382">
        <property type="term" value="P:epithelial cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903445">
        <property type="term" value="P:protein transport from ciliary membrane to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd14445">
        <property type="entry name" value="RILP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1770:FF:000003">
        <property type="entry name" value="RILP-like protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051241">
        <property type="entry name" value="DZIP_RILPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034743">
        <property type="entry name" value="RH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034744">
        <property type="entry name" value="RH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021563">
        <property type="entry name" value="RILP_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21502:SF2">
        <property type="entry name" value="RILP-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21502">
        <property type="entry name" value="ZINC FINGER PROTEIN DZIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09744">
        <property type="entry name" value="RH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11461">
        <property type="entry name" value="RILP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161256">
        <property type="entry name" value="RILP dimerisation region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51776">
        <property type="entry name" value="RH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51777">
        <property type="entry name" value="RH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RH1" evidence="13">
        <location>
            <begin position="17"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="RH2" evidence="14">
        <location>
            <begin position="122"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="162"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="183"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005025374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="193" mass="21512" checksum="C19F57EE2DB12375" modified="2022-01-19" version="1">MQRGGEDEEEDGEDDGGPESALQKSPFQLTAEDVYDISSVVGRDLLQLSAGPEVPAAVSRLQFSMVRVLEMLEALVSESSLSEEQLRMERDNLRAELEAVRGSGAPNLGPDKMVIDLTDPNRPRFTLQELRDVLQERNQLKAQLLVVQEELQCYKSGIISQRKDQTRELEQEPCGSSSGTSKNSHEKTIIKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UAG1</accession>
    <name>A0A8C2UAG1_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Solute carrier family 25 member 28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">SLC25A28</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Mitochondrial iron transporter that mediates iron uptake. Probably required for heme synthesis of hemoproteins and Fe-S cluster assembly in non-erythroid cells.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>Fe(2+)(in) = Fe(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:28486"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2UAG1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005033801.1">
        <property type="protein sequence ID" value="ENSCJPP00005024817.1"/>
        <property type="gene ID" value="ENSCJPG00005019528.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157049"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048250">
        <property type="term" value="P:iron import into the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000027">
        <property type="entry name" value="mitoferrin-2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000031">
        <property type="entry name" value="mitoferrin-2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45758">
        <property type="entry name" value="MITOFERRIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45758:SF20">
        <property type="entry name" value="MITOFERRIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0410">Iron transport</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 15 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 16" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="15">
        <location>
            <begin position="96"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="15">
        <location>
            <begin position="194"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="15">
        <location>
            <begin position="285"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="17">
        <location>
            <begin position="8"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00036243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005024817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="390" mass="41197" checksum="21C49146628E0553" modified="2022-01-19" version="1">MVARPRRGAGGGGQWESGGGAARGRGGGGGGAMELGAGAGAGAGPGARGGAESGLVRLLLMGGGAGRAGPGGAEAARGPEPRSPPAPDYEALPQGAAVSTHMLAGAVAGIMEHCVMYPIDCVKTRMQSLRPEPAARYRNVLEALWRIVRTEGVWRPMRGLNVTATGAGPAHALYFACYEKLKKTLSDVIHAGGNSHVANGAAGCVATLLHDAAMNPAEVVKQRMQMYNSPYQRVTDCVRTVWRNEGAGAFYRSYTTQLTMNIPFQAIHFMTYEFLQEHLNPHRQYNPGSHVVSGACAGAVAAAATTPLDVCKTLLNTQESLALSSNISGHITGMANAFRTVYQVGGVTAYFRGVQARVIYQMPSTAIAWSVYEFFKYILTKRQEERRAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UCR9</accession>
    <name>A0A8C2UCR9_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NCK associated protein 1 like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">NCKAP1L</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UCR9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005035036.1">
        <property type="protein sequence ID" value="ENSCJPP00005025785.1"/>
        <property type="gene ID" value="ENSCJPG00005020092.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000016619"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome LGE22C19W28_E50C23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031209">
        <property type="term" value="C:SCAR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904841">
        <property type="term" value="F:TORC2 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070358">
        <property type="term" value="P:actin polymerization-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050853">
        <property type="term" value="P:B cell receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030031">
        <property type="term" value="P:cell projection assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030866">
        <property type="term" value="P:cortical actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048821">
        <property type="term" value="P:erythrocyte development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030011">
        <property type="term" value="P:maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043318">
        <property type="term" value="P:negative regulation of cytotoxic T cell degranulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048812">
        <property type="term" value="P:neuron projection morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030838">
        <property type="term" value="P:positive regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030890">
        <property type="term" value="P:positive regulation of B cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902624">
        <property type="term" value="P:positive regulation of neutrophil migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042102">
        <property type="term" value="P:positive regulation of T cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904515">
        <property type="term" value="P:positive regulation of TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009410">
        <property type="term" value="P:response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019137">
        <property type="entry name" value="Nck-associated_protein-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12093">
        <property type="entry name" value="NCK-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12093:SF9">
        <property type="entry name" value="NCK-ASSOCIATED PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09735">
        <property type="entry name" value="Nckap1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="642"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="643"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="654"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005025785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1123" mass="126392" checksum="0BADE4E69308F566" modified="2022-01-19" version="1">MSLPSVYQNKFAEKLSILNERGRGVLVRIYNIKKVWGGTCSDPKTRPSFLCDKAMEPSIKFINKKFPNLDVRSSTQHLGPVHKDKGDIIRALGPYYYSFVDVLEFRDHVYELLNTIDANQCFFDININYDFTKSYLDLIVTYVSLVLLLARTEDRRVLIGMYHCAHEMSHGASDSSFARLGQMVLEYDHPLKKLTEEFGPHTKAVTAALLSLHFLFARRNQGSDQWRNDQLLSLLSSAGSMLSPASSDTMACEYLSLEVMERWILIGFLVCPGALGASPQCLELWRLALQGSLYITLLRDEALQIHKVTEELLSSLKGYGKRVADLKECKEHAVAHSGSLHRGRRLYLRGAVRELEALLEDQPGLLGPKALFAFMALSFCRDEVSWLVRHAEHVTKTKTPEDYADSHIAEILFLMEQLRSLVRRQDLVLRRYHVQYLARFDALVLSEIIQNLSVCPEEESIILSSFVSSLSSLSDKGVDEKEQFDFTALRLDWFRLQAYTSVSKAVLPLSTNPDVGRIMNLIVFHTKLLDSLEDLLAETSDLSDLCFFPRPIEKMFVATMEEPSMLRYSIAFPLLCSHFSRCVHPMCPEEYPQLQAAALGMCNKFLEEMARQTCACIMDSCAEQHNLSEQLLPKHCASTVSKARNKKTLKHPSKKGEPEREKPGAESQRKDRTVTTNMDKLHLVLAELSLSLNHVPNISVFEHTVTPAQYLSSHLETRFSKAIVAMACYSQPTQEVARPSEVLVGLGSYITFIQSLTHYVGLDTTRISSATSSLQQTQPRDCQGEQTLTTIYTNWWSAGCFWGHCGFVPIPNCDVPIPWYLGPIEMRALAELIGPYGMKFMSGQSHFWVVINCSQCRVPPLLQKLVNENMDTLVQLRSSPCKPEQMAALLPRLSSADNVLKRMTIIGEILSFRAMAQQGLREVFSHHCPFLMGPIGCLTDVVTPDTDIQVTLSIFELASAAGIPCEIDPALVNVLADGSSPEEDYKVSCLLLVFVAVSLPLLASDPMSIYNTEMDGYNNNIHCLAKAIIHVSAALFTLHNKNIETHLKEFLLLASMSLLQLGQETDKLRSRNRDAVCLLMQLIVAESSFLTVDMLETCFPYVLLRNAYREVCRESLLNRIPPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UD60</accession>
    <name>A0A8C2UD60_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Serine/threonine-protein kinase receptor</fullName>
            <ecNumber evidence="20">2.7.11.30</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">ACVR2A</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="19">On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. May modulate neuropeptide expression in dorsal root ganglia (DRG) neurons and ovarian follicle development.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-seryl-[receptor-protein] + ATP = O-phospho-L-seryl-[receptor-protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18673"/>
            <dbReference type="Rhea" id="RHEA-COMP:11022"/>
            <dbReference type="Rhea" id="RHEA-COMP:11023"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.30"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:18674"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-threonyl-[receptor-protein] + ATP = O-phospho-L-threonyl-[receptor-protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44880"/>
            <dbReference type="Rhea" id="RHEA-COMP:11024"/>
            <dbReference type="Rhea" id="RHEA-COMP:11025"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.30"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:44881"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="20">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Membrane</location>
            <topology evidence="20">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 20">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.30" evidence="20"/>
    <dbReference type="RefSeq" id="XP_015724749.1">
        <property type="nucleotide sequence ID" value="XM_015869263.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UD60"/>
    <dbReference type="Ensembl" id="ENSCJPT00005036178.1">
        <property type="protein sequence ID" value="ENSCJPP00005026720.1"/>
        <property type="gene ID" value="ENSCJPG00005020768.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107317053"/>
    <dbReference type="CTD" id="92"/>
    <dbReference type="GeneTree" id="ENSGT00940000157233"/>
    <dbReference type="OrthoDB" id="547665at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048179">
        <property type="term" value="C:activin receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034673">
        <property type="term" value="C:inhibin-betaglycan-ActRII complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048185">
        <property type="term" value="F:activin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016361">
        <property type="term" value="F:activin receptor activity, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016362">
        <property type="term" value="F:activin receptor activity, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098821">
        <property type="term" value="F:BMP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015026">
        <property type="term" value="F:coreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019838">
        <property type="term" value="F:growth factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034711">
        <property type="term" value="F:inhibin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030165">
        <property type="term" value="F:PDZ domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009952">
        <property type="term" value="P:anterior/posterior pattern specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009798">
        <property type="term" value="P:axis specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007368">
        <property type="term" value="P:determination of left/right symmetry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048706">
        <property type="term" value="P:embryonic skeletal system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001702">
        <property type="term" value="P:gastrulation with mouth forming second"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048333">
        <property type="term" value="P:mesodermal cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030279">
        <property type="term" value="P:negative regulation of ossification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001649">
        <property type="term" value="P:osteoblast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043084">
        <property type="term" value="P:penile erection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032927">
        <property type="term" value="P:positive regulation of activin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030501">
        <property type="term" value="P:positive regulation of bone mineralization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045648">
        <property type="term" value="P:positive regulation of erythrocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045669">
        <property type="term" value="P:positive regulation of osteoblast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060391">
        <property type="term" value="P:positive regulation of SMAD protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045428">
        <property type="term" value="P:regulation of nitric oxide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060011">
        <property type="term" value="P:Sertoli cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042713">
        <property type="term" value="P:sperm ejaculation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd14141">
        <property type="entry name" value="STKc_ACVR2a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23631">
        <property type="entry name" value="TFP_LU_ECD_ACVR2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000099">
        <property type="entry name" value="Serine/threonine-protein kinase receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.60.10:FF:000002">
        <property type="entry name" value="Serine/threonine-protein kinase receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000094">
        <property type="entry name" value="Serine/threonine-protein kinase receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.60.10">
        <property type="entry name" value="CD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000333">
        <property type="entry name" value="TGFB_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23255:SF64">
        <property type="entry name" value="ACTIVIN RECEPTOR TYPE-2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23255">
        <property type="entry name" value="TRANSFORMING GROWTH FACTOR-BETA RECEPTOR TYPE I AND II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00653">
        <property type="entry name" value="ACTIVIN2R"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="20" id="KW-0460">Magnesium</keyword>
    <keyword evidence="20" id="KW-0464">Manganese</keyword>
    <keyword evidence="13 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15 20" id="KW-0675">Receptor</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 20" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8 21" id="KW-0732">Signal</keyword>
    <keyword evidence="5 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034366861" description="Serine/threonine-protein kinase receptor" evidence="21">
        <location>
            <begin position="24"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="22">
        <location>
            <begin position="192"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00055142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU361271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005026720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="513" mass="58120" checksum="2CC28AB7FF732662" modified="2022-01-19" version="1">MGAATKLAFAVFLISCSSGAILGRSETQECIYYNANWEKDKTNRSGIEPCYGDKDKRRHCFATWKNISGSIEIVKQGCWLDDINCYDRNDCIEKKDSPEVFFCCCEGNMCNERFFYFPEMEVTQPTSNPVTPKPPLFNTLLYSLVPIMGIAVIVLFSFWMYRHHKLAYPPVLVPTQDPGPPPPSPLMGLKPLQLLEIKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEIYSLPGMKHDNILQFIGAEKRGTSIDVDLWLITAFHEKGSLTDFLKANVVSWNELCHIAQTMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTASDGPVDEYMLPFEEEIGQHPSLEDMQEVVVHKKKRPVLRECWQKHSGMAMLCETIEECWDHDAEARLSAGCVEERIIQMRKLTNIITTEDIVTVVTMVTNVDFPPKESSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UDE4</accession>
    <name>A0A8C2UDE4_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytosolic iron-sulfur assembly component 2A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">MIP18 family protein FAM96A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">CIAO2A</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">Monomer and homodimer. Component of the CIA complex. Interacts with CIAO1. Interacts with IREB2. Interacts with APAF1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MIP18 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_032302700.1">
        <property type="nucleotide sequence ID" value="XM_032446809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UDE4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005036731.1">
        <property type="protein sequence ID" value="ENSCJPP00005027122.1"/>
        <property type="gene ID" value="ENSCJPG00005021059.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107318886"/>
    <dbReference type="KEGG" id="cjo:107318886"/>
    <dbReference type="CTD" id="84191"/>
    <dbReference type="GeneTree" id="ENSGT00390000017697"/>
    <dbReference type="OrthoDB" id="2746at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097361">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly targeting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.130:FF:000004">
        <property type="entry name" value="cytosolic iron-sulfur assembly component 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039796">
        <property type="entry name" value="MIP18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12377:SF2">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12377">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="Fe-S cluster assembly (FSCA) domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00062218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00074929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00082916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005027122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="161" mass="18344" checksum="6953D24BE41B1174" modified="2022-01-19" version="1">MSLVLGLLSHTLSRVLRYSGLSRGCHAPSRGAMEHDKAMEVYDIIRTIRDPEKPNTLEELEVVTESCVKVNEISEEEYLVVIRFTPTVPHCSLATLIGLCLRIKLQRCLPFRHKLEIYISEGTHSTEEDINKQINDKERVAAAMENPNLREIVEQCVMEPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UDL3</accession>
    <name>A0A8C2UDL3_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LIM/homeobox protein Lhx9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LHX9</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015724840.1">
        <property type="nucleotide sequence ID" value="XM_015869354.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015724842.1">
        <property type="nucleotide sequence ID" value="XM_015869356.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UDL3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005036841.1">
        <property type="protein sequence ID" value="ENSCJPP00005027218.1"/>
        <property type="gene ID" value="ENSCJPG00005021116.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107317098"/>
    <dbReference type="KEGG" id="cjo:107317098"/>
    <dbReference type="CTD" id="56956"/>
    <dbReference type="GeneTree" id="ENSGT00940000158821"/>
    <dbReference type="OrthoDB" id="9990008at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008283">
        <property type="term" value="P:cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008585">
        <property type="term" value="P:female gonad development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035262">
        <property type="term" value="P:gonad morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008584">
        <property type="term" value="P:male gonad development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09469">
        <property type="entry name" value="LIM1_Lhx2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09377">
        <property type="entry name" value="LIM2_Lhx2_Lhx9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000027">
        <property type="entry name" value="LIM/homeobox protein Lhx9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000039">
        <property type="entry name" value="LIM/homeobox protein Lhx9 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000033">
        <property type="entry name" value="LIM/homeobox protein Lhx9 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050453">
        <property type="entry name" value="LIM_Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208">
        <property type="entry name" value="LIM/HOMEOBOX PROTEIN LHX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208:SF95">
        <property type="entry name" value="LIM_HOMEOBOX PROTEIN LHX9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 10 12" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 11" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="14">
        <location>
            <begin position="69"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="14">
        <location>
            <begin position="131"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="15">
        <location>
            <begin position="265"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="10">
        <location>
            <begin position="267"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="330"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="353"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="387"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005027218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="397" mass="44255" checksum="490D7711CEE17ACD" modified="2022-01-19" version="1">MEIVGCRAEENTCPFRPPAMLFHGISGGHIQGIMEEMERRSKTESRLAKGGQMNGRETNMPPMSPEKPALCAGCGGKISDRYYLLAVDKQWHMRCLKCCECKLNLESELTCFAKDGSIYCKEDYYRRFSVQRCARCHLGISASEMVMRARESVYHLSCFTCTTCNKTLTTGDHFGMKDNLVYCRAHFESLLQGEYPPQLSYTELAAKSGGLALPYFNGTGTVQKGRPRKRKSPALGVDIVNYNSGCNENEADHMDRDQQPYPPSQKTKRMRTSFKHHQLRTMKSYFAINHNPDAKDLKQLAQKTGLTKRVLQVWFQNARAKFRRNLLRQENGGVDKADGTSLPAPPSADSGALTPPGTATTLTDLTNPTITVVTSVTSNLDSHEPGSPSQTTLTNLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UE55</accession>
    <name>A0A8C2UE55_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane 6 superfamily member 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">TM6SF1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">May function as sterol isomerase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TM6SF family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015728459.1">
        <property type="nucleotide sequence ID" value="XM_015872973.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UE55"/>
    <dbReference type="Ensembl" id="ENSCJPT00005035134.1">
        <property type="protein sequence ID" value="ENSCJPP00005025879.1"/>
        <property type="gene ID" value="ENSCJPG00005020222.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107318758"/>
    <dbReference type="KEGG" id="cjo:107318758"/>
    <dbReference type="CTD" id="53346"/>
    <dbReference type="GeneTree" id="ENSGT00390000012913"/>
    <dbReference type="OrthoDB" id="8181520at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd21106">
        <property type="entry name" value="TM6SF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033118">
        <property type="entry name" value="EXPERA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047195">
        <property type="entry name" value="TM6SF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059044">
        <property type="entry name" value="TM_Tm6sf1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14568:SF10">
        <property type="entry name" value="TRANSMEMBRANE 6 SUPERFAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14568">
        <property type="entry name" value="TRANSMEMBRANE SUPERFAMILY 6 MEMBER 1/2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05241">
        <property type="entry name" value="EBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26083">
        <property type="entry name" value="TM_Tm6sf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51751">
        <property type="entry name" value="EXPERA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0458">Lysosome</keyword>
    <keyword evidence="5 10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="EXPERA" evidence="12">
        <location>
            <begin position="60"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="EXPERA" evidence="12">
        <location>
            <begin position="216"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005025879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="370" mass="41543" checksum="675E102E4C353417" modified="2022-01-19" version="1">MSASAATGVFVLSLTAIPVTYVFNCLAAGGSSWSIVAVGLLVLVFIALLARVLVKRKPPKDPLFYVYAVFAFTSVVNLIIGLEQDGIIDGFMTHYLREGEPYLNTAYGHVICYWDGSVHYLMYLLMVAAIAWEQSYRTIGLYWLGSIFMSIIVFMPGNIVGKYGTKVCPAFFLSVPYICLPIWAGFRIYNQPPATHDTPVKVVQEVQKKGLLRRPVDLMLAAYLILAAGFCIFRGMIALDCPAELCRLYIQLHEPYIKDPAAYPKLQMLAYMFYSVPYYVIALYGLLVPGCSWMPDLTLIHAGGLAQAQFSHIGASLHARTPYIYRVPEEAKQFFLILNIMYGILPQLLAYRCVHKPEFFMKAKEEDKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UEC2</accession>
    <name>A0A8C2UEC2_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">La ribonucleoprotein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LARP4</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UEC2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005034221.1">
        <property type="protein sequence ID" value="ENSCJPP00005025133.1"/>
        <property type="gene ID" value="ENSCJPG00005019749.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154409"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome LGE22C19W28_E50C23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022604">
        <property type="term" value="P:regulation of cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd08035">
        <property type="entry name" value="LARP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12707">
        <property type="entry name" value="RRM_LARP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034903">
        <property type="entry name" value="LARP4_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058699">
        <property type="entry name" value="RRM_LARP4/4B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792:SF48">
        <property type="entry name" value="LA-RELATED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26088">
        <property type="entry name" value="RRM_LARP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="5">
        <location>
            <begin position="113"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="14"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="375"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="422"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="559"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="626"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="565"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="597"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="662"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005025133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="735" mass="80033" checksum="C345CFC0808224D6" modified="2022-01-19" version="1">MLLFVEVTSKGAGLNPNAKVWQEGPQGSGEAAPPSNGTELPWHEPAAVAGTQTEGNAEISEESCKHYEVMYSTSCEAARNGTGIDEAAANGIVLTTEDLGYQIYEVAGEGNSVVSTEDIRECLRKQLEFCFSRENLSKDLYLMSQMDSDQFVPIWTIANMEGIKKLTTDMDLILDVLRSSPMVQVDETGEKVRPNHKRCIVILREIPETTPVEEVKALFKNENCPKVISCEFAHNNNWYVTFQSDTDAQQAFKYLREEVKTFQGKPIMARIKAINTFFAKNGYRVVDSSVYAQPVQTQAQFASPLFMQPVYSPQQYSIYSIVPQTWSPNPAPYFETPLAPFPNGGFVNGFNTPGSYKTSAASLSIGRPFHRNRVKPHFRSSHSSEHAAEGPAAAGTVSVGDGTLSRTNSRNFVMERHNSTLTGHQEQGYSQKDSPTMQMEQNGDYGIGRGRRNIFRGRRRREDDRISRPQPSTEIKTQTPKFDLLASNFPPLPGSTAKIPGELMLESRMSDVVKGIGKEKESKDLLPSCPASAPEEQTHSVVQQAVSSSGQAEAVVLSSAVQTESKPEEVSVQKDVKSHTSPPASVCPVSAAKPPRTNTTSSPTNTNAAPAVAVQEPRKLSYAEVCQKPPKEPPPVPVQPLRELRTNVDPPAKSDSSATAERAAEKAADKAEGRMKDHSGFRGSGTPVWTQIIASGSAAACGQGAVRATTVTKVTPVRLVPLFNWSCGLMSSKGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UF01</accession>
    <name>A0A8C2UF01_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 13">Peroxiredoxin-6</fullName>
            <ecNumber evidence="13">1.11.1.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">PRDX6</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41223"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:72998"/>
            <dbReference type="ChEBI" id="CHEBI:72999"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:41224"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + CoA</text>
            <dbReference type="Rhea" id="RHEA:35983"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:72998"/>
            <dbReference type="ChEBI" id="CHEBI:72999"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:35984"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA</text>
            <dbReference type="Rhea" id="RHEA:12937"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="EC" id="2.3.1.23"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 13">
            <text>a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62632"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="EC" id="1.11.1.27"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the peroxiredoxin family. Prx6 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.27" evidence="13"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2UF01"/>
    <dbReference type="Ensembl" id="ENSCJPT00005037133.1">
        <property type="protein sequence ID" value="ENSCJPP00005027476.1"/>
        <property type="gene ID" value="ENSCJPG00005021300.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00550000074794"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047184">
        <property type="term" value="F:1-acylglycerophosphocholine O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047499">
        <property type="term" value="F:calcium-independent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048026">
        <property type="term" value="P:positive regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd03016">
        <property type="entry name" value="PRX_1cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1020.10:FF:000001">
        <property type="entry name" value="1-Cys peroxiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000011">
        <property type="entry name" value="Peroxiredoxin PRX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1020.10">
        <property type="entry name" value="Antioxidant, Horf6, Chain A, domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045020">
        <property type="entry name" value="PRX_1cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503">
        <property type="entry name" value="MCG48959-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503:SF4">
        <property type="entry name" value="PEROXIREDOXIN-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 13" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 13" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="6 13" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="15">
        <location>
            <begin position="4"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity" evidence="14">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00026214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR000239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005027476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="237" mass="26330" checksum="A638369838F9A7A0" modified="2022-01-19" version="1">MPGLLLGDEAPNFEADTTQGRIRFHDFLGDSLCVPAWGRKVGGGWGILFSHPRDFTPVCTTELGRAAKLASEFSKRNVKMIALSIDSVPDHLAWSKDINAYNGDQPVEKLPFPIIADKNRELAVKLGMLDPDERDKDGMPLTARVVFIFGPDKKLKLSILYPATTGRNFDEILRVVDSLQLTAYKKVATPVDWKSGDSVMVVPTLPDEEAKKLFPKGVFTKDLPSGKKYLRYTPQPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UGB2</accession>
    <name>A0A8C2UGB2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">NEK6-subfamily protein kinase</fullName>
            <ecNumber evidence="14">2.7.11.34</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">NEK7</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Spindle pole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.34" evidence="14"/>
    <dbReference type="RefSeq" id="XP_015724848.1">
        <property type="nucleotide sequence ID" value="XM_015869362.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015724849.1">
        <property type="nucleotide sequence ID" value="XM_015869363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UGB2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005036838.1">
        <property type="protein sequence ID" value="ENSCJPP00005027215.1"/>
        <property type="gene ID" value="ENSCJPG00005021114.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107317099"/>
    <dbReference type="KEGG" id="cjo:107317099"/>
    <dbReference type="CTD" id="140609"/>
    <dbReference type="GeneTree" id="ENSGT00940000156725"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140677">
        <property type="term" value="F:molecular function activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035865">
        <property type="term" value="P:cellular response to potassium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070498">
        <property type="term" value="P:interleukin-1-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035655">
        <property type="term" value="P:interleukin-18-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044546">
        <property type="term" value="P:NLRP3 inflammasome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050729">
        <property type="term" value="P:positive regulation of inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032731">
        <property type="term" value="P:positive regulation of interleukin-1 beta production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032741">
        <property type="term" value="P:positive regulation of interleukin-18 production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900227">
        <property type="term" value="P:positive regulation of NLRP3 inflammasome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032206">
        <property type="term" value="P:positive regulation of telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070269">
        <property type="term" value="P:pyroptotic inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd08224">
        <property type="entry name" value="STKc_Nek6_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000148">
        <property type="entry name" value="Serine/threonine-protein kinase Nek7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000204">
        <property type="entry name" value="Serine/threonine-protein kinase Nek7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000240">
        <property type="entry name" value="Serine/threonine-protein kinase Nek7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43289">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43289:SF2">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 15 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="34"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005027215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="302" mass="34552" checksum="A0997487FAD761C3" modified="2022-01-19" version="1">MDEQTQGMQGPAAPPFQPQKALRPDMGYNTLANFRIEKKIGRGQFSEVYRATCLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLNHPNVIKYLDSFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLCKKIEQCDYPPLPSDHYSEELRQLVNMCINPDPEKRPDITYVYDVAKRMHAHTASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UGN2</accession>
    <name>A0A8C2UGN2_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin specific peptidase like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">USPL1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UGN2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005035489.1">
        <property type="protein sequence ID" value="ENSCJPP00005026182.1"/>
        <property type="gene ID" value="ENSCJPG00005020420.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000002316"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015030">
        <property type="term" value="C:Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016929">
        <property type="term" value="F:deSUMOylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032183">
        <property type="term" value="F:SUMO binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030576">
        <property type="term" value="P:Cajal body organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008283">
        <property type="term" value="P:cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016926">
        <property type="term" value="P:protein desumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009301">
        <property type="term" value="P:snRNA transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029388">
        <property type="entry name" value="DUF4650"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028890">
        <property type="entry name" value="Peptidase_C98"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033505">
        <property type="entry name" value="USPL1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15294">
        <property type="entry name" value="RETINOVIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15294:SF3">
        <property type="entry name" value="SUMO-SPECIFIC ISOPEPTIDASE USPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15509">
        <property type="entry name" value="DUF4650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15499">
        <property type="entry name" value="Peptidase_C98"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="2">
        <location>
            <begin position="229"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="540"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="599"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="837"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="837"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="872"/>
            <end position="881"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005026182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1109" mass="123067" checksum="F538EF21DAD29238" modified="2022-01-19" version="1">MDTQKTANGLRVIGQGTGIGKSTLHMVGYLGKGHTPVEKTSPDYCPVCKEKGQVQVLRTYRINFQESIYLCENPQCIYPLGYKPFNSIIISADSENLQVPSNDKKRKLCDTNDLSPIESNPKQARTNKKVEQTINTDPVVKNCGDSLSIPQSSVCDVLENGQQKSNSEESINQKVDFKTTSNTNGHQESPPKNFSSGTQLLPNSTHSSTTSEVLFRDKNCSTNNTGLCLQWRNKCNLCWLDCVLSALVHLEALKFALVEDDEKCLLQRLLTKYNQAAVLLNTCKRSKVKDVLPKAELLLNEIRNQIFIQLQPQLKCELGKEESPVFALPLLLKQDQQAEKLFLHSFSWEFECVCCGYKYLDRCRKTLTTFTNIIPDWHPLNAVHVAPCNNCSDRSQRRRMILEEVPSVLMFHFVEGLPHNNLKSYSFQLEEDVYQITSVIQYDMHKKHFISWSLNPDGTWLECDDLKGLYCRRHKRFEVPPTEIHIVMWEKKASRLTEEQNSQHQSTNIEDSTANNVQLKSTVLHHGFDNAVGNILEKEHQEDSVRIPDKKQQQVAGGESSVNGDLENLAHDDLLTQILGESPLDSESKSVLNAKMTESNLVETGSQEKQESASSSNTPYRGEFIGTDLATSDTDMLSENSSICLSLQELNLASITPPVPRKQDPNPSDLSLAQSMGDRASLLNGEHGLSSGQQINCKLPPVENIAQKSPDLKGASKITVRSQVAVHSSDNNSFQPSDKDQKRGFVGSWVKKLLSKNTSFLPSSALMPKNEKSCRTPSVQKLNDTWLPVKGASNFGGFQGRGECKTSQPLTSALPRSNNAHCLSRFKGFSQGTCLPQNHNTVEGPTWNKSSNTLGSSGKTTQVHPPSCNSVKAEESDSDKTRKLRLKLLKKLNAKKKKLASLDRLAMEQAKRGKPVAGDVSAPSQIESHNGSELLQSVLSELQHHIDAADNSSEFSVNSGCTSHNSNDEILAELLSPTSTVASSEVPKSEDECMYMEMVNSSSAAPAEPAEKTGVSHTAVTSEDRSYYGPIKDSNYERTMSKSSVKKLGFESPTREDILEDLFSISAPSTIAGDIDVPHFDETLFETWAAHPYVYTGKWQEEVRSLGET</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UH75</accession>
    <name>A0A8C2UH75_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Low density lipoprotein receptor-related protein 1B</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UH75"/>
    <dbReference type="Ensembl" id="ENSCJPT00005035670.1">
        <property type="protein sequence ID" value="ENSCJPP00005026335.1"/>
        <property type="gene ID" value="ENSCJPG00005020487.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00900000141555"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005026335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="163" mass="18023" checksum="2EEE9A43930A48AB" modified="2022-01-19" version="1">CLINSTILIGSFRCSANWSGTQCERPAPKSSKSDNISTRSIAIIVPLVLLVTLITTLVIGLFLCKRKRRTKTIRRQPIINGGINVEIGNPSYNMYEVGHDHSEGGLLASDFTVNAEKPTNYSNPVYAKLYMDGQNCRNSLASVDERRELLPKKIDIGIRETVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UJN7</accession>
    <name>A0A8C2UJN7_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Metastasis associated 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">MTA1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the metastasis-associated protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015724916.1">
        <property type="nucleotide sequence ID" value="XM_015869430.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UJN7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005037008.1">
        <property type="protein sequence ID" value="ENSCJPP00005027367.1"/>
        <property type="gene ID" value="ENSCJPG00005021230.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107317126"/>
    <dbReference type="CTD" id="9112"/>
    <dbReference type="GeneTree" id="ENSGT01030000234573"/>
    <dbReference type="OrthoDB" id="2193595at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016581">
        <property type="term" value="C:NuRD complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042826">
        <property type="term" value="F:histone deacetylase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061629">
        <property type="term" value="F:RNA polymerase II-specific DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045814">
        <property type="term" value="P:negative regulation of gene expression, epigenetic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902499">
        <property type="term" value="P:positive regulation of protein autoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010212">
        <property type="term" value="P:response to ionizing radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd04709">
        <property type="entry name" value="BAH_MTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11661">
        <property type="entry name" value="SANT_MTA3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000012">
        <property type="entry name" value="Metastasis-associated 1 family, member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.490:FF:000001">
        <property type="entry name" value="Metastasis-associated 1 family, member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1240.50:FF:000001">
        <property type="entry name" value="Metastasis-associated 1 family, member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000949">
        <property type="entry name" value="ELM2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040138">
        <property type="entry name" value="MIER/MTA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035170">
        <property type="entry name" value="MTA1_R1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10865">
        <property type="entry name" value="METASTASIS-ASSOCIATED PROTEIN AND MESODERM INDUCTION EARLY RESPONSE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10865:SF5">
        <property type="entry name" value="METASTASIS-ASSOCIATED PROTEIN MTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01426">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01448">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17226">
        <property type="entry name" value="MTA_R1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00439">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01189">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51156">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BAH" evidence="13">
        <location>
            <begin position="4"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="ELM2" evidence="14">
        <location>
            <begin position="148"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="15">
        <location>
            <begin position="266"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="418"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00093454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005027367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="694" mass="79374" checksum="0B109359AE8E6E3C" modified="2022-01-19" version="1">MAANMYRVGDYVYFENSSSNPYLIRRIEELNKTANGNVEAKVVCFYRRRDISSTLIVLADKHAREMEEEMENPEMVDLPEKQKHQLRHRELFLSRQLESLPATHIRGKCSVTLLNETESLKSYLEREDFFFYSLVYDPQQKTLLADKGEIRVGNRYQADITDLLKEGEDDGRDQSKLETKVWEAFNPLVDKQIDQFLVVARSVGTFARALDCSSSVRQPSLHMSAAAASRDITLFHAMDTLHKNVYDISKAISALVPQGGPVLCRDEMEEWSASEANLFEEALEKYGKDFTDIQQDFLPWKSLTSIIEYYYMWKTTDRYVQQKRLKAAEAESKLKQVYIPNYNKPNPNQINVNNVKPGVVNGTGVQAQNATAGRACESCYTTQSYQWYSWGPPNMQCRLCASCWTYWKKYGGLKMPTRLDGERPGPNRNNLSPHGVPVRNSGSPKFAMKTRQAFYLHTTKLTRIARRLCRDILRPWHAARHPYLPINSAAIKAECTARLPEASENPLLLKQVVRKPLEAVLRYLESHPCPPKPDPAKSLSSSLNNLTPAKFTPVINNGSPTILGKRSYEQHNGMDGNMKKRLLMPSRGLPNHGQTRQMGPSRNLLLNGKSYPTKVRLIRGGSMPPVKRRRMNWIDAPDDVFYMATEETRKIRKLLSSSEAKRAARRPYKPIILRPIQAVQLRQPMNDEPIIIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UK88</accession>
    <name>A0A8C2UK88_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Centrosomal protein 350</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">CEP350</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015725104.1">
        <property type="nucleotide sequence ID" value="XM_015869618.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015725105.1">
        <property type="nucleotide sequence ID" value="XM_015869619.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015725106.1">
        <property type="nucleotide sequence ID" value="XM_015869620.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015725107.1">
        <property type="nucleotide sequence ID" value="XM_015869621.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005037261.1">
        <property type="protein sequence ID" value="ENSCJPP00005027583.1"/>
        <property type="gene ID" value="ENSCJPG00005021373.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107317214"/>
    <dbReference type="KEGG" id="cjo:107317214"/>
    <dbReference type="CTD" id="9857"/>
    <dbReference type="GeneTree" id="ENSGT00940000155130"/>
    <dbReference type="OrthoDB" id="306254at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034453">
        <property type="term" value="P:microtubule anchoring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071539">
        <property type="term" value="P:protein localization to centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028750">
        <property type="entry name" value="CEP350/CC187"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13958:SF3">
        <property type="entry name" value="CAP-GLY DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13958">
        <property type="entry name" value="CENTROSOME-ASSOCIATED PROTEIN 350"/>
        <property type="match status" value="1"/>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y5P9</accession>
    <name>A0A8C2Y5P9_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sulfotransferase</fullName>
            <ecNumber evidence="5">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y5P9"/>
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        <property type="protein sequence ID" value="ENSCJPP00005001826.1"/>
        <property type="gene ID" value="ENSCJPG00005001871.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161848"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000433">
        <property type="entry name" value="Estrogen sulfotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="7">
        <location>
            <begin position="45"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005001826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="295" mass="33782" checksum="C21AC44CBF42B252" modified="2022-01-19" version="1">KPAMHSTEHNLQLKPLPLCCTVHSIPMVNAFAQNWERVDNFQSRPDDIVVATFPKSGTTWISEIVDMVLQGGDPKKCKRDAIINRVPMLEFAAPGQMPAGSGLWLAGMLFPCIIKSYIPADILPKSFWDKNCKMIYVGRNAKDVAVSYYHFDLMNKLHPHPGTWDQYLEAFMAGKVAYGSWFDHVRGYWERRQEHPILYLFYEDMKEDLRREIAKVAQFLGRELTEVALEAIAHHTSFEAMRDNPSTNYSVVPSHLMDHSISPFMRKGEQPQWASKPLIPSGPVQTLLNPPRHHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y6I1</accession>
    <name>A0A8C2Y6I1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cysteine-rich protein 2-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ADA2A-containing complex subunit 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">CRP2-binding partner</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Lysine acetyltransferase 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">KAT14</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. May function as a scaffold for the ATAC complex to promote ATAC complex stability. Has also weak histone acetyltransferase activity toward histone H4. Required for the normal progression through G1 and G2/M phases of the cell cycle.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Interacts with the LIM 1 domain of CSRP2. Component of the ADA2A-containing complex (ATAC), composed of CSRP2BP, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1. In the complex, it probably interacts directly with KAT2A, MBIP and WDR5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015712616.1">
        <property type="nucleotide sequence ID" value="XM_015857130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y6I1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005006949.1">
        <property type="protein sequence ID" value="ENSCJPP00005004069.1"/>
        <property type="gene ID" value="ENSCJPG00005004121.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107310982"/>
    <dbReference type="KEGG" id="cjo:107310982"/>
    <dbReference type="CTD" id="57325"/>
    <dbReference type="GeneTree" id="ENSGT00390000001146"/>
    <dbReference type="OrthoDB" id="4080456at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140672">
        <property type="term" value="C:ATAC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051302">
        <property type="term" value="P:regulation of cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045995">
        <property type="term" value="P:regulation of embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000013">
        <property type="entry name" value="cysteine-rich protein 2-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.980.20:FF:000004">
        <property type="entry name" value="Cysteine-rich protein 2-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.980.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20916">
        <property type="entry name" value="CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20916:SF26">
        <property type="entry name" value="CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="14">
        <location>
            <begin position="637"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="248"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="313"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="409"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="409"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="446"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00053435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00064759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00077405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00079321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00079746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005004069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="781" mass="88941" checksum="7C85C53BDA765722" modified="2022-01-19" version="1">MANNVHMSGLLSRHDDEATRTSTSEGLEEGEVEGETLLIVESEDQASVDLSHDQSGDSLNSDEGDVSWMEEMSYYCEKCQKWIPASQLREQLSYLKGDNFFRFTCSDCSEDGKEQFERLRLTWQQVVMLAMYNLSLEGTGRQGYFRWKEDICAFIEKHWTFLLGNRKKTSTWWSTVAGCLSVGSPLYFRSGAQEFGEPGWWKLVHNKPPTMKPEGEKLSASALKAKAASKPPLDPIITVEGLRKRVSRNPVESAMELKEKRSRTQEAKDIRRAQKEAAGFLDRSTSSTPVKFSSRGRRPDIVLEKGEVIDFSSLSSSDRTPLTSPSPSPSLDFSAPGTPASHSATPSLLSEADLIPDVMPPQALFHDDEEMEGDGVIDPGIEYVPPPSGTAGAGTMIASRKKVKTAEQIKQEVESEEEKTERMEGDIEDPEESNASLQLRGRDKRKPQLEKDTKPRAPKHTSVSIYEEKLLLKRLEACPNALNMTPEARRLRRKLIVRQAKRERGLPLFDLDQVVNAALLLVDGIYGAKEGVSRSPVGQATYRTTSQDFRILDRYQTVLPAMKGYRQQTTKFLYRLVGSEDLLSDYSIVSPYTSRVLKPYIRRDYETKPPKLRLLAEIWAYPHRNDLNWKAEPEAPIDYCYVRPNHIPTINSMCHEFFWPGIDLSECLQYPDFSVVVLYKKVIIAFGFMVPDVKYNEAYISFLFVHPEWRRAGIATFMIYHLIQTCMGKDVTLHVSASNPAMLLYQKFGFKTEEYILDFYDKYYPLDSKECKHAFFLRLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y707</accession>
    <name>A0A8C2Y707_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Plexin C1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">PLXNC1</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y707"/>
    <dbReference type="Ensembl" id="ENSCJPT00005008393.1">
        <property type="protein sequence ID" value="ENSCJPP00005005120.1"/>
        <property type="gene ID" value="ENSCJPG00005004958.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286928"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0150053">
        <property type="term" value="C:cerebellar climbing fiber to Purkinje cell synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002116">
        <property type="term" value="C:semaphorin receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017154">
        <property type="term" value="F:semaphorin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007162">
        <property type="term" value="P:negative regulation of cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050772">
        <property type="term" value="P:positive regulation of axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030334">
        <property type="term" value="P:regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905806">
        <property type="term" value="P:regulation of synapse pruning"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00102">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00603">
        <property type="entry name" value="IPT_PCSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1680.10:FF:000020">
        <property type="entry name" value="Plexin C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1680.10">
        <property type="entry name" value="ligand-binding face of the semaphorins, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031148">
        <property type="entry name" value="Plexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013548">
        <property type="entry name" value="Plexin_cytoplasmic_RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046800">
        <property type="entry name" value="Plexin_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002165">
        <property type="entry name" value="Plexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016201">
        <property type="entry name" value="PSI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22625">
        <property type="entry name" value="PLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22625:SF4">
        <property type="entry name" value="PLEXIN-C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08337">
        <property type="entry name" value="Plexin_cytopl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20170">
        <property type="entry name" value="Plexin_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01437">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00423">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103575">
        <property type="entry name" value="Plexin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="513"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="PSI" evidence="5">
        <location>
            <begin position="47"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005005120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1016" mass="115672" checksum="0BB0EDDDC057A3A4" modified="2022-01-19" version="1">MKSNCPEILYEIEEETSIFPKLRLDPVDSNYIYLSSANKVRRIPVANCGRYVSEQECLSAKDPYCGWCSLNQRCTLKENCTRSNSTKGWLNISHAPDRDLKILLRFPARNQISVSASKSKTLTSCIIKIVKPIEMPHENVVLKNSSCVCNLSTPVTLDNDCLVLEASLSSSSWNITETFQLENCSRCIHDGECASCNWTRVSPASACQGTCSVQNASKDITTARKSEHINIHSIKPLWISTLGKSEITVKGENFTHESGIKLILTGSSGCKQEIIKVRNVINDTQMTFALPPTRKEAKSVCVQADGRKCSPPVTLHYVSLPACFGITPNTSWISGGRRITTTGRNLNVVDKVIISDDQRSNLTISECPQNKSEYHYLSPSLSHATEGKVVDMIFKVETTFIPCVKLHYHPDPVFINYQLHTELDPDLELKIYKENDNLNISKTEVEVYLLYMNGSQTAKIYFSVQNITEKPDRSTILCKFKREGTEKIDFSTVKVFVKLGNFELEVKPTSSYIYLYVLILVPIVVGVIIVAFIVTRYKSKELTRKQSQQLELLEYEIRKEIREGFAELQMDELDVVDSFGTVPFLDYKHFAIRTFFPEETIGEPFYLLVTTLNQKINKGPVDAITCKALYTLNEDWLLWQVSEFKTVTVNVIFEKIPENESGDACQTIQVNVLDCDTIGQTKEKSLQAFLNKNGFPYGLHLDEIGLELVSEEQQRELLDIDGTSEMMEDGITKLNTIAHYKIANGATVKVLKKKRSNRSDMDYSDEHCHLILPDSEANKDLKGSGHKGKQKFKVKEMYLTKLLSTKVAIHSVVENLFRSIWSLPNNKAPVAIKYFFDFLDAQAESKRITDPDVVHIWKTNSLPLRFWVNILKNPQFVFDVKKTSHIDGCLSVIAQAFMDAFSLAEQTMGKEAPTNKLLYAKDIPLYKKEVKAYYKAIRDLPPLTTSEVEEFLTQESKKHENEFNEEVALMEIYRYIVKYYDEIVSKLERERGFEDVQKQLQQVKALFDEKKKCKWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y7F9</accession>
    <name>A0A8C2Y7F9_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">RAD21 cohesin complex component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">RAD21</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the rad21 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015711704.1">
        <property type="nucleotide sequence ID" value="XM_015856218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y7F9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005009003.1">
        <property type="protein sequence ID" value="ENSCJPP00005005566.1"/>
        <property type="gene ID" value="ENSCJPG00005005297.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107310505"/>
    <dbReference type="KEGG" id="cjo:107310505"/>
    <dbReference type="CTD" id="5885"/>
    <dbReference type="GeneTree" id="ENSGT00940000154655"/>
    <dbReference type="OrthoDB" id="10071381at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030893">
        <property type="term" value="C:meiotic cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030892">
        <property type="term" value="C:mitotic cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140588">
        <property type="term" value="P:chromatin looping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010972">
        <property type="term" value="P:negative regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045841">
        <property type="term" value="P:negative regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045876">
        <property type="term" value="P:positive regulation of sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071168">
        <property type="term" value="P:protein localization to chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21792">
        <property type="entry name" value="Rad21_Rec8_M_NXP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.580:FF:000001">
        <property type="entry name" value="double-strand-break repair protein rad21 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.580">
        <property type="entry name" value="Structural maintenance of chromosome 1. Chain E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049589">
        <property type="entry name" value="NXP1_M-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039781">
        <property type="entry name" value="Rad21/Rec8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006909">
        <property type="entry name" value="Rad21/Rec8_C_eu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006910">
        <property type="entry name" value="Rad21_Rec8_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023093">
        <property type="entry name" value="ScpA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585:SF20">
        <property type="entry name" value="DOUBLE-STRAND-BREAK REPAIR PROTEIN RAD21 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585">
        <property type="entry name" value="SCC1 / RAD21 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04824">
        <property type="entry name" value="Rad21_Rec8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04825">
        <property type="entry name" value="Rad21_Rec8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad21/Rec8-like protein N-terminal" evidence="9">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Rad21/Rec8-like protein C-terminal eukaryotic" evidence="8">
        <location>
            <begin position="576"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="243"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="423"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="272"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="523"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="534"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005005566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="632" mass="71825" checksum="2F093CB2CE733B08" modified="2022-01-19" version="1">MFYAHFVLSKRGPLAKIWLAAHWDKKLTKAHVFECNLESSVESIISPKVKMALRTSGHLLLGVVRIYHRKAKYLLADCNEAFIKIKMAFRPGVVDLPEENREAAYNAITLPEEFHDFDQPLPDLDDIDVAQQFSLNQSRVEEITMREEVGNISILQDNDFGDFGMDDREMMREGSAFEDDMLVSTSASNLLLEPEQSTSHLNEKANHLEYEDQYKDDNFGEGNDGGILDDKLLSNNDGGIFDDPPALSEGGVMMPEQPPHDDMDDDDNVSMGGPDSPDSVDPVEPLPTMTDQTTLVPNEEEAFALEPIDITVKETKAKRKRKLIVDSVKELDSKTIRAQLSDYSDIVTTLDLAPPTKKLMMWKESGGAETLLSQPAQPLWNNRLLKLFTRCLTPLVPEDLRKRRKGGEADNLDEFLKDFENPEVPREEQQQQQQQQRDVIDEPILEEPSRLQESMMEGSRTNLDESVMPPPPPQTGVKRKLQQAEPEPVLPHPPSQQLEMPPVEMPPEEPQNICQLIPELELLPEKEKEKEKEKEEEEEEEEEDGTGGDQDQEERRWNKRTQQMLHGLQRALAKTGAESISLLELCRNTNRKQAAAKFYSFLVLKKQQAIELTQEEPYSDIIATPGPRFHII</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y7H0</accession>
    <name>A0A8C2Y7H0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 15">m7GpppX diphosphatase</fullName>
            <ecNumber evidence="5 15">3.6.1.59</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">DCPS</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3'-&gt;5' exosome-mediated mRNA decay pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = N(7)-methyl-GMP + a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:65388"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="Rhea" id="RHEA-COMP:17167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58285"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="EC" id="3.6.1.59"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Associates with components of the exosome multienzyme ribonuclease complex, such as EXOSC3 and EXOSC4. Interacts with NDOR1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the HIT family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.59" evidence="5 15"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y7H0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005009639.1">
        <property type="protein sequence ID" value="ENSCJPP00005006082.1"/>
        <property type="gene ID" value="ENSCJPG00005005716.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000003924"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140932">
        <property type="term" value="F:5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.40:FF:000001">
        <property type="entry name" value="m7GpppX diphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000006">
        <property type="entry name" value="m7GpppX diphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.40">
        <property type="entry name" value="Scavenger mRNA decapping enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008594">
        <property type="entry name" value="DcpS/DCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011145">
        <property type="entry name" value="Scavenger_mRNA_decap_enz_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12978">
        <property type="entry name" value="HISTIDINE TRIAD HIT PROTEIN MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12978:SF0">
        <property type="entry name" value="M7GPPPX DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05652">
        <property type="entry name" value="DcpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11969">
        <property type="entry name" value="DcpS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028973">
        <property type="entry name" value="Scavenger_mRNA_decap_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102860">
        <property type="entry name" value="mRNA decapping enzyme DcpS N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 15" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="12" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="13 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="16">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="260"/>
            <end position="271"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR028973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR028973-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR028973-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="329" mass="37793" checksum="BB6AE5265D780A89" modified="2022-01-19" version="1">RRMATPPPSPLSPGAAAPSGLRRRDEAEAAPVGSSFPLGSVRLRRLLRDSAREKAAFVHGQVVGAAGEETDAVLILEKTPFQEEKIEELLRRHGKMELQMSNDIYSTYRLQPPPELSEIKVTVVHPATEKHLQKYLRQEVHLIRETWEDYKNITLPFIQSQSFSIQWVYNILEKKAEADRIIHENPDPCNGFVLVPDFKWNQNQLEDLYLIALIHRRDVKSLRDLTAEHLPLLRNILQEGKEAITKHFGVPGSQLRIYLHYQPSYYHLHVHFTALGYDAPGCSVERAHLLEDVMDNLLLDAQHYQKRALTFPLRADEPLLKRFQEAGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y812</accession>
    <name>A0A8C2Y812_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="30">Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform</fullName>
            <ecNumber evidence="8">2.7.1.137</ecNumber>
            <ecNumber evidence="6">2.7.1.153</ecNumber>
            <ecNumber evidence="7">2.7.1.154</ecNumber>
            <ecNumber evidence="9">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="34">Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="33">Phosphoinositide-3-kinase catalytic gamma polypeptide</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="31">Serine/threonine protein kinase PIK3CG</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="32">p120-PI3K</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="41" type="primary">PIK3CG</name>
    </gene>
    <organism evidence="41 42">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="41" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="41" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="41" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18373"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57658"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.154"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:18374"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12709"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.137"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:12710"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.153"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:21293"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Phospholipid metabolism; phosphatidylinositol phosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="29">Heterodimer of a catalytic subunit PIK3CG and a PIK3R5 or PIK3R6 regulatory subunit. Interacts with GRK2 through the PIK helical domain. Interaction with GRK2 is required for targeting to agonist-occupied receptor. Interacts with PDE3B; regulates PDE3B activity and thereby cAMP levels in cells. Interacts with TPM2. Interacts with EPHA8; regulates integrin-mediated cell adhesion to substrate. Interacts with HRAS; the interaction is required for membrane recruitment and beta-gamma G protein dimer-dependent activation of the PI3K gamma complex PIK3CG:PIK3R6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.137" evidence="8"/>
    <dbReference type="EC" id="2.7.1.153" evidence="6"/>
    <dbReference type="EC" id="2.7.1.154" evidence="7"/>
    <dbReference type="EC" id="2.7.11.1" evidence="9"/>
    <dbReference type="RefSeq" id="XP_032298315.1">
        <property type="nucleotide sequence ID" value="XM_032442424.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032298319.1">
        <property type="nucleotide sequence ID" value="XM_032442428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y812"/>
    <dbReference type="Ensembl" id="ENSCJPT00005011168.1">
        <property type="protein sequence ID" value="ENSCJPP00005007198.1"/>
        <property type="gene ID" value="ENSCJPG00005006644.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107306688"/>
    <dbReference type="CTD" id="5294"/>
    <dbReference type="GeneTree" id="ENSGT00940000156858"/>
    <dbReference type="OrthoDB" id="67688at2759"/>
    <dbReference type="UniPathway" id="UPA00220"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005943">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class IA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005944">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class IB"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016303">
        <property type="term" value="F:1-phosphatidylinositol-3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046934">
        <property type="term" value="F:1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035005">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046875">
        <property type="term" value="F:ephrin receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001525">
        <property type="term" value="P:angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071320">
        <property type="term" value="P:cellular response to cAMP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
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        <property type="term" value="P:negative regulation of fibroblast apoptotic process"/>
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        <property type="term" value="P:phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
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        <property type="entry name" value="C2_PI3K_class_I_gamma"/>
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        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
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    </dbReference>
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        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
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    </dbReference>
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        <property type="entry name" value="Ubiquitin-like"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0037">Angiogenesis</keyword>
    <keyword evidence="20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="21" id="KW-0391">Immunity</keyword>
    <keyword evidence="24" id="KW-0395">Inflammatory response</keyword>
    <keyword evidence="19" id="KW-0418">Kinase</keyword>
    <keyword evidence="22" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="23" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="42" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K-ABD" evidence="37">
        <location>
            <begin position="34"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K-RBD" evidence="39">
        <location>
            <begin position="217"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="C2 PI3K-type" evidence="40">
        <location>
            <begin position="357"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="PIK helical" evidence="38">
        <location>
            <begin position="544"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="36">
        <location>
            <begin position="800"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="35">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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            <dbReference type="ARBA" id="ARBA00004805"/>
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            <dbReference type="ARBA" id="ARBA00005189"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00006209"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012010"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00012013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000256" key="19">
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023098"/>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
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            <dbReference type="ARBA" id="ARBA00048977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00080619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
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            <dbReference type="ARBA" id="ARBA00083126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="35">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="36">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="37">
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    </evidence>
    <evidence type="ECO:0000259" key="38">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="39">
        <source>
            <dbReference type="PROSITE" id="PS51546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="40">
        <source>
            <dbReference type="PROSITE" id="PS51547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="41">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005007198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="42">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1106" mass="127931" checksum="E7608D0B0122B57C" modified="2022-01-19" version="1">MELDENEQPVVMREENKRRRRRMKPHCTSSNLSSMELISIEFILPTNNKHTKVPETVLLEIAGNCTVEQMKAQIWMRAIEMSQTTDFYHAFTPDQFVLQYQKKGQWYEIYDKHQLLQTLDCILYWKVLQKKVGKIYVVQKQKPSEEVQEFQRQLNDLIGYDVTDVSNVHDDELEFTRRRLVTPRMIEVACRDPKLYAMHPWTTSKPLPEYLFKKITNNNIFIIIHRGTTSQKIKVSIDDTPDTILHSFFTKMAKKKSLMDIPEDHSELDFVLRICGRDEYIIGDTPIKDFHWIRQCLKNGEEIHLVLDNPPDPSEDEVQKEEWPLVDDCTGVTGYHEQLTIDGKDHERVFTISLWDCNRKFRVKIIGIDIPVLPRNTDLTVFVEANIQHGQQLLSQRRTSSKPFTEEVLWNIWLEFDIKIKDLPKGALLNLQIYCGKAQGLSTKTNLQSHESPNSDSKCKTQLLYYVNLLLIDHRFLLRSGEYVLHMWKIPGKGEDQGSINADKLTSATNPDKENSMAISIVLDKYCHPIALPKHRITSDSQGDRTRAEMPNQLRKQLEEIIATDPLNPLSPEDKELLWHFRYESIKHPKAYPKLLSSVKWGQQEIVAKTYQLLAKKEVWDQSTLDVGLTMQLLDCNFSDENVRAMAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSMHYQQRFAVILEAYLRGCGKAMLQDFMKQVQVIELLHKVTMEIKSVSAEKYDVTSQVIVQLRQKLEKLQGSKLPESFRVPYDPGLRAGALVIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWEAESLDLCLLPYGCISTGNKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEILNQWLKDRCVIEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSLHFHKFQDVCVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKSEEDAKKHFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGVEKHSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y8T9</accession>
    <name>A0A8C2Y8T9_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">AT-rich interaction domain 1B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ARID1B</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y8U1</accession>
    <name>A0A8C2Y8U1_COTJA</name>
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            <fullName evidence="21">Elongation of very long chain fatty acids protein 5</fullName>
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            <fullName evidence="21">3-keto acyl-CoA synthase ELOVL5</fullName>
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            <fullName evidence="21">ELOVL fatty acid elongase 5</fullName>
            <shortName evidence="21">ELOVL FA elongase 5</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Very long chain 3-ketoacyl-CoA synthase 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Very long chain 3-oxoacyl-CoA synthase 5</fullName>
        </alternativeName>
    </protein>
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        <name evidence="21 24" type="primary">ELOVL5</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate in the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. In conditions where the essential linoleic and alpha linoleic fatty acids are lacking it is also involved in the synthesis of Mead acid from oleic acid.</text>
    </comment>
    <comment type="function">
        <text evidence="21">Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>(11Z)-octadecenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(13Z)-eicosenoyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:39679"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:75121"/>
            <dbReference type="ChEBI" id="CHEBI:76559"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:39680"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + malonyl-CoA + H(+) = (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:36475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57368"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:73852"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:36476"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>(6Z,9Z,12Z)-octadecatrienoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(8Z,11Z,14Z)-eicosatrienoyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:35379"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57363"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:71481"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:35380"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:35391"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:71489"/>
            <dbReference type="ChEBI" id="CHEBI:71491"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:35392"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(9Z)-hexadecenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(11Z)-octadecenoyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:39675"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:61540"/>
            <dbReference type="ChEBI" id="CHEBI:76555"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:39676"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>(9Z)-octadecenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(11Z)-eicosenoyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:36511"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:74011"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:36512"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(9Z,12Z)-octadecadienoyl-CoA + malonyl-CoA + H(+) = (11Z,14Z)-3-oxoicosa-11,14-dienoyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:36503"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57383"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:74012"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:36504"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(9Z,12Z,15Z)-octadecatrienoyl-CoA + malonyl-CoA + H(+) = (11Z,14Z,17Z)-3-oxoeicosatrienoyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:36523"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:74034"/>
            <dbReference type="ChEBI" id="CHEBI:74054"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:36524"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21 22">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="21">Lipid metabolism; polyunsaturated fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="21">Endoplasmic reticulum membrane</location>
            <topology evidence="21">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="21">Cell projection</location>
            <location evidence="21">Dendrite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <text evidence="21">In Purkinje cells, the protein localizes to the soma and proximal portion of the dendritic tree.</text>
    </comment>
    <comment type="similarity">
        <text evidence="21">Belongs to the ELO family. ELOVL5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.199" evidence="21"/>
    <dbReference type="RefSeq" id="XP_015714733.1">
        <property type="nucleotide sequence ID" value="XM_015859247.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015714734.1">
        <property type="nucleotide sequence ID" value="XM_015859248.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y8U1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005013336.1">
        <property type="protein sequence ID" value="ENSCJPP00005008855.1"/>
        <property type="gene ID" value="ENSCJPG00005007852.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107312117"/>
    <dbReference type="KEGG" id="cjo:107312117"/>
    <dbReference type="CTD" id="60481"/>
    <dbReference type="GeneTree" id="ENSGT01050000244838"/>
    <dbReference type="OrthoDB" id="434092at2759"/>
    <dbReference type="UniPathway" id="UPA00658"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036109">
        <property type="term" value="P:alpha-linolenic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043651">
        <property type="term" value="P:linoleic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042759">
        <property type="term" value="P:long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035338">
        <property type="term" value="P:long-chain fatty-acyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045723">
        <property type="term" value="P:positive regulation of fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006636">
        <property type="term" value="P:unsaturated fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03205">
        <property type="entry name" value="VLCF_elongase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033677">
        <property type="entry name" value="ELOVL5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF18">
        <property type="entry name" value="ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 21" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5 21" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 21 22" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6 21 22" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 21 22" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 21 22" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 21 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 21 22" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 21 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 21 22" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21 22">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21 22">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21 22">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21 22">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21 22">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21 22">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="276"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00052042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005008855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="295" mass="35154" checksum="0C5DE9E9AA608B5F" modified="2022-01-19" version="1">MERLDQTINSYLDVWLGPRDPRVKGWLLLENYTPTFIFSALYLLIVWLGPKYMRNKQPFSCRGILVVYNLGLTLLSLYMFYELVTGVWEGGYNFYCQDTHSGGEADMKIIRVLWWYYFSKLIEFMDTFFFILRKNNHQITVLHVYHHATMLNIWWFVMNWVPCGHSYFGATLNSFIHVLMYSYYGLSAVPAMRPYLWWKKYITQGQLIQFVLTIFQTSCGVVWPCAFPQGWLYFQIFYMISLIILFTNFYIQTYNKKASSRRKEYQNGSTATVNGYTNSFSSLENNVKQRKQRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YBA6</accession>
    <name>A0A8C2YBA6_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ADP-ribosylation factor-like protein 4A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">ARL4A</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Interacts with CYTH2. Interacts with KPNA2; the interaction is direct. Does not interact with ARL4A.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2YBA6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005020099.1">
        <property type="protein sequence ID" value="ENSCJPP00005014059.1"/>
        <property type="gene ID" value="ENSCJPG00005011786.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154546"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04152">
        <property type="entry name" value="Arl4_Arl7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000658">
        <property type="entry name" value="ADP-ribosylation factor-like protein 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0519">Myristate</keyword>
    <keyword evidence="7 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="22"/>
            <end position="29"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="129"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00055358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00066179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00072379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005014059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="195" mass="22256" checksum="4BE8CB38D99FF3C1" modified="2022-01-19" version="1">VGKLFSCIHLPSFQCFHIVILGLDSAGKTTVLYRLQFNEFVNTVPTKGFNTEKIKVTLGNSKTVTFHFWDVGGQEKLRPLWKSYTRCTDGIVFVVDSVDVERMEEAKTELHKITRISENQGVPVLIVANKQDLRNSLSLSEIEKMLAMSELSSSTPWHLQPTCAIIGDGLKEGLEKLYDMIIKRRKMLRQQKKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YBZ4</accession>
    <name>A0A8C2YBZ4_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">[histone H3]-trimethyl-L-lysine(27) demethylase</fullName>
            <ecNumber evidence="15">1.14.11.68</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 2 2-oxoglutarate + 2 O2 = N(6)-methyl-L-lysyl(27)-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO2</text>
            <dbReference type="Rhea" id="RHEA:60224"/>
            <dbReference type="Rhea" id="RHEA-COMP:15535"/>
            <dbReference type="Rhea" id="RHEA-COMP:15544"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="1.14.11.68"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the UTX family.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.68" evidence="15"/>
    <dbReference type="Ensembl" id="ENSCJPT00005021571.1">
        <property type="protein sequence ID" value="ENSCJPP00005015188.1"/>
        <property type="gene ID" value="ENSCJPG00005009018.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155202"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044666">
        <property type="term" value="C:MLL3/4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071558">
        <property type="term" value="F:histone H3K27me2/H3K27me3 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007507">
        <property type="term" value="P:heart development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000022">
        <property type="entry name" value="lysine-specific demethylase 6A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1370:FF:000001">
        <property type="entry name" value="lysine-specific demethylase 6A isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.20:FF:000001">
        <property type="entry name" value="lysine-specific demethylase 6A isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.650:FF:000002">
        <property type="entry name" value="lysine-specific demethylase 6A isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000011">
        <property type="entry name" value="lysine-specific demethylase 6A isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1370:FF:000002">
        <property type="entry name" value="lysine-specific demethylase 6A isoform X6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051630">
        <property type="entry name" value="Corepressor-Demethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046941">
        <property type="entry name" value="KDM6_GATAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048562">
        <property type="entry name" value="KDM6A_B-like_C-hel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048560">
        <property type="entry name" value="KDM6A_B-like_GATAL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14017">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14017:SF9">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21322">
        <property type="entry name" value="KDM6_C-hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21326">
        <property type="entry name" value="KDM6_GATAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="10" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 17" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="repeat" description="TPR" evidence="17">
        <location>
            <begin position="130"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="17">
        <location>
            <begin position="319"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="19">
        <location>
            <begin position="1148"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="476"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="676"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="865"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="966"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1097"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="492"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="676"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="714"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="868"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="888"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="18">
        <location>
            <begin position="971"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1099"/>
            <end position="1116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1454" mass="160146" checksum="520A848CC4F6FA1F" modified="2022-01-19" version="1">MKSCGVSLAAAAASAAPFGDEEKKMAAGKASGQSEEDFASLTAEEREALSGLDSRLFGFLRLHEDGARTKALLLKAVRCYESLILKAEGKVESDFFCQLGHFNLLLEDYPKALSAYQRYYSLQSDYWKNAAFLYGLGLVYFHYNAFQWAIKAFQEALYVDPSFCRAKEIHLRLGLMFKVNTDYESSLKHFQLALIDCNPCTLSNAEKFMINQFTSFLLQRKYHSAKEAYEQLLQIENLPAQVKATVLQQLGWMHHTVDQLGDKATKESYAIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGTLYESCNQPQDAIKCYLNATRSKNCSNTSALAARIKYLQAQLCNLPQGSLQNKTKLLPSIEEAWSLPIPAELTSRQGAMNTAQQACKPHHPNTEPVLGLTQTPISQQSLPLHMIPSSQVDDLTSPAKRKRTSSPTKNTSDVWSSGHTVSHPPVQQQIHSWCLTPQKLQHLEQLRANRNNLNPAQKLMLEQLESQFVLMQQHQQMRQTGVAQVRSTGIPNGPTADSSLPTNSVSGQQPQVALTRVPNVAQRGIRPACPGQPMANGPFPAGPIPCSTARTLSSTDTILIGNNHITESGSNGNVPYLQQNALSLPHNRTNLTSSAEEPWKNQLSNSTQGLHKGQSSHLAGPNGERPLSSTGPSQHLQASGTGIQNQNGHPATPSNSVTQGAALNHLSSHTATSGGQQGITLTKESKPSGNTSAVPETSRHSGETPNSTAGVEGLPNHVHQVTADAVSSPSHGDSKSPGLLSSDNPQLSALLMGKANNNVGTGTCDKVNNIHPAVHTKTENSIASSPSSAISTATPSPKSTEQTTTNSVTSLNSPHSGHTVNGEGLEDSQSPVKADPPPISHKPSPQIIPSMSVSIYPSSAEVLKACRNLGKNGLSNSSILLDKCPPPRPPPPPYPPLPKDKLNPPTPSIYLENKRDAFFPPLHQFCTNPNNPVTVIRGLAGALKLDLGLFSTKTLVEANNEHVVEVRTQLLQPADENWDPTGTKKIWRCESSRSHTTIAKYAQYQASSFQESLREENEKKSHHKDHSDNESTSSDNSGRRRRGPFKTIKFGTNIDLSDDKKWKLQLHELTKLPAFVRVVSAGNLLSHVGHTILGMNTVQLYMKVPGSRTPGHQENNNFCSVNINIGPGDCEWFVVPESYWGVMNDFCEKNNMNFLMGSWWPNLEDLYEANVPVYRFIQRPGDLVWINAGTVHWVQAIGWCNNIAWNVGPLTACQYKLAVERYEWNKLQSVKSIVPMVHLSWNMARNIKVSDPKLFEMIKYCLLRTLKQCQTLREALIAAGKEIVWHGRAKDEPAHYCSICEVEVFDLLFVTSESNSRKTYVVHCQDCARKISTNLENFVVLEQYKMEDLMQVYDQFTLAPPLPSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YC30</accession>
    <name>A0A8C2YC30_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">small monomeric GTPase</fullName>
            <ecNumber evidence="4">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">RALB</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Midbody</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="4"/>
    <dbReference type="RefSeq" id="XP_015724121.1">
        <property type="nucleotide sequence ID" value="XM_015868635.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015724122.1">
        <property type="nucleotide sequence ID" value="XM_015868636.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015724123.1">
        <property type="nucleotide sequence ID" value="XM_015868637.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YC30"/>
    <dbReference type="Ensembl" id="ENSCJPT00005022154.1">
        <property type="protein sequence ID" value="ENSCJPP00005015655.1"/>
        <property type="gene ID" value="ENSCJPG00005012939.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107316773"/>
    <dbReference type="KEGG" id="cjo:107316773"/>
    <dbReference type="CTD" id="5899"/>
    <dbReference type="GeneTree" id="ENSGT00940000155984"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019003">
        <property type="term" value="F:GDP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000786">
        <property type="term" value="P:positive regulation of autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045742">
        <property type="term" value="P:positive regulation of epidermal growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045089">
        <property type="term" value="P:positive regulation of innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031623">
        <property type="term" value="P:receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04139">
        <property type="entry name" value="RalA_RalB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000203">
        <property type="entry name" value="Putative ras-related protein ral-a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0488">Methylation</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0636">Prenylation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="181"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="206" mass="23376" checksum="AE45CBD8814952B5" modified="2022-01-19" version="1">MAASKGKNQSSLALHKVIMVGSGGVGKSALTLQFMYDEFVEDYEPTKADSYRKKVVLDGEEVQIDILDTAGQEDYAAIRDNYFRSGEGFLLVFSITEHESFTATAEFREQILRVKAEEDKIPLLVVGNKSDLEERRQVPVEEARNKAEEWGVQYVETSAKTRANVDKVFFDLMREIRAKKMSENKDKNGKKSGKNKKSFKERCCLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YC90</accession>
    <name>A0A8C2YC90_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2YC90"/>
    <dbReference type="Ensembl" id="ENSCJPT00005022290.1">
        <property type="protein sequence ID" value="ENSCJPP00005015776.1"/>
        <property type="gene ID" value="ENSCJPG00005013023.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163951"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050427">
        <property type="entry name" value="Olfactory_Receptors"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48002">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="274" mass="30103" checksum="489212F74E282869" modified="2022-01-19" version="1">MCIGCALHVSTQLINMGNASSAKEFIPMSLSQKQGVQKVYSVILLFFYTSSVAGNIVTVMSSQHLNSPMYFFLCYLVFPKMIADFLVKNKTISFVGCMIVIFIMMAYGCYTANCGPFHCTTLMTQSACGCMVISSWVGGFVHCSMQTLLITLLPFCGPNKVDHYFCDVHPLLQLACQSHFFILVVSYVVILVSLRSHTSEGRRKALSTCGSHITVVVLFFGPCTFTHPTSSLPEDKVLALSVVAGASTPAVNPLIYSTRNQEFKDVVRKLLGKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YCW5</accession>
    <name>A0A8C2YCW5_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Rho guanine nucleotide exchange factor 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">ARHGEF11</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015739909.1">
        <property type="nucleotide sequence ID" value="XM_015884423.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005023937.1">
        <property type="protein sequence ID" value="ENSCJPP00005017134.1"/>
        <property type="gene ID" value="ENSCJPG00005014022.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107324422"/>
    <dbReference type="CTD" id="9826"/>
    <dbReference type="GeneTree" id="ENSGT00940000158350"/>
    <dbReference type="OrthoDB" id="2272012at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd23069">
        <property type="entry name" value="PDZ_ARHGEF11-12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13391">
        <property type="entry name" value="PH_PRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08753">
        <property type="entry name" value="RGS_PDZRhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.167.10:FF:000010">
        <property type="entry name" value="Rho guanine nucleotide exchange factor (GEF) 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.900.10:FF:000006">
        <property type="entry name" value="Rho guanine nucleotide exchange factor (GEF) 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000033">
        <property type="entry name" value="Rho guanine nucleotide exchange factor (GEF) 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000072">
        <property type="entry name" value="Rho guanine nucleotide exchange factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037889">
        <property type="entry name" value="PDZRhoGEF_RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041020">
        <property type="entry name" value="PH_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037803">
        <property type="entry name" value="PRG_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015212">
        <property type="entry name" value="RGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45872:SF1">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45872">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 2, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17838">
        <property type="entry name" value="PH_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09128">
        <property type="entry name" value="RGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="PDZ" evidence="15">
        <location>
            <begin position="58"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="14">
        <location>
            <begin position="788"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="13">
        <location>
            <begin position="1019"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="137"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="321"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="564"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="629"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1137"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1169"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1264"/>
            <end position="1423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1456"/>
            <end position="1519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="139"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="158"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="325"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="575"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="635"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="655"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="705"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1288"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1325"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1352"/>
            <end position="1363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="1384"/>
            <end position="1402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1488"/>
            <end position="1503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00057618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00074303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005017134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1519" mass="167946" checksum="3227F6C66A1D4C1D" modified="2022-01-19" version="1">MSVRPPQAAPDRAGSKRQRLPRLSSLSSLGDSSSERRSPGHRRQPSDSSETTGLVQRCVIIQKDQHGFGFTVSGDRIVLVQSVRPGGAAMKAGVQEGDRIVKVNGTMVTNSSHLEVVKLIKSGAYVALTLLGSPPPSVGLSNSQQDTSTTGAPRNAPACPPPPPPPPLPPPQRITGPKPLQDPEVQKHATQILRNMLRQEEAELQRFYEAYNRNPGTVVGEQIEGARRRVSQLQLKIRQETSGSMDLGRLSGDSSMAMFRAAEGRLSVDSQDGDSGLESGTERFPSVSEISLNRNSVLSDHGLDSPRTSPVITARLFQHHRRQGSDTAFTPTTEQGSERTGRPLIIGPEEDYDPGYFNNECDSLFQDLSKLKSRPAHLGVFLRYIFSQADPSPLLFYLCADVCQQTTAKDSRGLGKDIWNIFLDRNAPLRVKVSEQLLSEIEARLRNGDDVRAALFEAQEMVMPEIQEQIQDYRTKRTMGLGSLYGENDLLDLDGDPQKERQVAEKQLAQLGDILSKYEEDRSSPMAFALSTYMNHTGIRSREPRVASTSEKAQALPDKDKWLPFFPKAKKSSSTKKDKDAMEDKKRNPILKYIAKPKMSQSTFHVPLSPVEAVKPGNVRNIIQHFENNQHYDNQEPGSQRLSTGSFPEDLLEGDGSRAEVKLGRSESLKGREEMKKSRKAENVPRSRSDVDMDAAAEATRLHQSASSSASSLSTRSLENPTPPYTPKMGRRSIESPSLGFGADPFLPHLLEDEQGQLSDLESELDAQNWQHTVGRELLASLPQKEIDRQEVINELFATEVSHLRILRVLDLLFYQRMRKESLLSREELALLFPNLPDVIEIHNSLSESMKKLREEGPIIKEIGDLMLSRFDGLAKEEIQQVTADFCSYQSIALELIKTKQRKETRFQIFMQEAESNPQCRRLQLKDLIISEMQRLTKYPLLLENILKHTEAGTSEHDKLCRARDHCRDILKYVNEAVKQAENRHRLEGYQKRLDATSLERTSNPLAAEFKSLDLTSRRMIHEGPLTWRISKDKTVDLHVLLLEDLLVLLQKQDEKLVLKCHGKTALGSLDNKQTFSPILKLNSVLIRSVATDKRAFFIICTSELGPQIYELVALTSSEKNTWMEVLEEAVQSAMRNATFPPKRQMPEPTRMAPSSLVLQDPDVSPILSQVSSSAAEAEESSSADDNPTELLGREQPPVLPEEPGSSEVEEEELPPGPLQTEVSDAHPEPSMRLALPVPSPAEGLAEAALEDVENLRLLILRRLLPSRDTEPEDDLTPTPSVIGGTHTWDSVLSSQDSASQELLAEPQSAAEEPKSRSGLEEQNETGPTVSAEEQSSYKVVRKAPAEGAQEATLSPGSSQTETELQEGGGANVDGNYFYVSMPTGPPEPVPPPGPPQAFPPEEPPRPSAAEGPPDPPGPLRDVDLIFRTIEQLTLKLNRLKAVEAAHWELLQSLGHSSSADTTPVGHPAPGMEGWTQQPHSPEGGSPLTRSLRSLQGHSTNIPGSRAPLAEDPTHTADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YD80</accession>
    <name>A0A8C2YD80_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">CKLF like MARVEL transmembrane domain containing 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">CMTM3</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2YD80"/>
    <dbReference type="Ensembl" id="ENSCJPT00005025044.1">
        <property type="protein sequence ID" value="ENSCJPP00005018033.1"/>
        <property type="gene ID" value="ENSCJPG00005014645.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005025045.1">
        <property type="protein sequence ID" value="ENSCJPP00005018034.1"/>
        <property type="gene ID" value="ENSCJPG00005014645.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160432"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050578">
        <property type="entry name" value="MARVEL-CKLF_proteins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22776:SF3">
        <property type="entry name" value="CKLF-LIKE MARVEL TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22776">
        <property type="entry name" value="MARVEL-CONTAINING POTENTIAL LIPID RAFT-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51225">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
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            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
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        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="8">
        <location>
            <begin position="137"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
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            <end position="126"/>
        </location>
    </feature>
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            <end position="282"/>
        </location>
    </feature>
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        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
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            <begin position="95"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005018033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="282" mass="30560" checksum="97CCC8D3977163E5" modified="2022-01-19" version="1">MTPVSALRVGTRPMPSSSSGRAAVRSQSPSRPVPSRPTVVAAASGAARGGERPGRGSAVPPRPSPGSRCTFGDAERLWVFFSRFRSVTISASLLQKKKKKRKKKRAARSRAPAAMDEPGDNAEPPPGLRSLLPPREFLCSRKGQLLLAEAVLSFIIFICYIASSASAFMTAPLLEFLLALFLLFAYASKLNEKFKGLYWPLTDFLRCVTAAVIYFAISIAAVSKYSDGASKAAGVFGFIATIVYAIDFYITFNDLVTFLKQGSSEAHERRKSEDEDSDSDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YDC7</accession>
    <name>A0A8C2YDC7_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Microtubule associated protein 1 light chain 3 beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">MAP1LC3B</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Autophagosome membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the ATG8 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015729680.1">
        <property type="nucleotide sequence ID" value="XM_015874194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YDC7"/>
    <dbReference type="SMR" id="A0A8C2YDC7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005025227.1">
        <property type="protein sequence ID" value="ENSCJPP00005018130.1"/>
        <property type="gene ID" value="ENSCJPG00005014754.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107319423"/>
    <dbReference type="KEGG" id="cjo:107319423"/>
    <dbReference type="CTD" id="81631"/>
    <dbReference type="GeneTree" id="ENSGT00940000154158"/>
    <dbReference type="OrthoDB" id="6738456at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17235">
        <property type="entry name" value="Ubl_ATG8_MAP1LC3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000059">
        <property type="entry name" value="Microtubule-associated proteins 1A/1B light chain 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004241">
        <property type="entry name" value="Atg8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10969">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEINS 1A/1B LIGHT CHAIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02991">
        <property type="entry name" value="ATG8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9 11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="lipid moiety-binding region" description="Phosphatidylserine amidated glycine; alternate" evidence="11">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR604241-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005018130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="125" mass="14618" checksum="DE07409C83B1B996" modified="2022-01-19" version="1">MPSEKSFKQRRTFEQRVEDVRLIRDQHPTKIPVIIERYKGEKQLPVLDKTKFLVPDHVNMSELIKIIRRRLQLNSNQAFFLLVNGHSMVSVSTPISEVYESEKDEDGFLYMVYASQETFGVQSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YDV4</accession>
    <name>A0A8C2YDV4_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Steroid 21-hydroxylase</fullName>
            <ecNumber evidence="16">1.14.14.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">21-OHase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Cytochrome P-450c21</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">Cytochrome P450 21</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Cytochrome P450 XXI</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Cytochrome P450-C21</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="primary">CYP21A2</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="23">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 24">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.16" evidence="16"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2YDV4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005026814.1">
        <property type="protein sequence ID" value="ENSCJPP00005019342.1"/>
        <property type="gene ID" value="ENSCJPG00005015697.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005026816.1">
        <property type="protein sequence ID" value="ENSCJPP00005019344.1"/>
        <property type="gene ID" value="ENSCJPG00005015697.1"/>
    </dbReference>
    <dbReference type="KEGG" id="cjo:107321560"/>
    <dbReference type="GeneTree" id="ENSGT00940000158338"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103069">
        <property type="term" value="F:17-hydroxyprogesterone 21-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106309">
        <property type="term" value="F:progesterone 21-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004508">
        <property type="term" value="F:steroid 17-alpha-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005496">
        <property type="term" value="F:steroid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034651">
        <property type="term" value="P:cortisol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042446">
        <property type="term" value="P:hormone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042448">
        <property type="term" value="P:progesterone metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000049">
        <property type="entry name" value="steroid 21-hydroxylase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24289">
        <property type="entry name" value="STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24289:SF17">
        <property type="entry name" value="STEROID 21-HYDROXYLASE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 23 24" id="KW-0349">Heme</keyword>
    <keyword evidence="11 23 24" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 23 24" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12 24" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10 24" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0754">Steroid-binding</keyword>
    <keyword evidence="15" id="KW-0755">Steroidogenesis</keyword>
    <feature type="binding site" description="axial binding residue" evidence="23">
        <location>
            <position position="466"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00044265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00044282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00044304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00044342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005019342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="525" mass="56965" checksum="4D29B2109EB9EBD7" modified="2022-01-19" version="1">MNFGGGRGVATRCPCSGRRVLGVGGVELLGSLPFIRCYRGRAGPPPHTPHRAMVAVMLLLLLLLALIWGGSARRGGAPWWGVFHLLHPEGPQHLHILTRTYGDPLCLRLGGREVVVLSSAAAIREALARRWGDFVGRPHSYLASLVSRGGQDLALGDASPEWRRQRGATRGALARAVRHLEPILELQGWALCRELSSYGAAPVDLFEAFAFHTCSTICRLAFGDLMPPEAEVRSFTRCVVELLEVWGRASVRALDVLPPLRVLPNPGLRELLRLVKSRDAFVETQIRWHQGCASPPADTVLGALLGGDPTVPMGPLGGDRLHMALVDLFIGGTETTAAALLWAVAFLLHHPQVQDRVRAELRQVLGPTGTPKPGDMGRLPLLRATITETLRLRPTAPLALPHCARRHSSIAGMLVPAGSIIIPNLFAAHHDPKVWDRPDEFLPERFLQPGAPWRALLPFGCGARSCVGEALARAELFVFLGHILQRFRLEPPSDGALPHLGVTAGTVLRCAPFRVRLVPCPPHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YFQ5</accession>
    <name>A0A8C2YFQ5_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein phosphatase 6 regulatory subunit 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">PPP6R3</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAPS family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2YFQ5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005031849.1">
        <property type="protein sequence ID" value="ENSCJPP00005023210.1"/>
        <property type="gene ID" value="ENSCJPG00005018445.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000009899"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019903">
        <property type="term" value="F:protein phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007587">
        <property type="entry name" value="SAPS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12634:SF12">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 6 REGULATORY SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12634">
        <property type="entry name" value="SIT4 YEAST -ASSOCIATING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04499">
        <property type="entry name" value="SAPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="639"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="740"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="851"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="655"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="667"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="740"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005023210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="884" mass="99468" checksum="EFEC17C56426DCBD" modified="2022-01-19" version="1">MLCVCSFIQTSMFWKFDLHSSSHIDTLLEREDVTLKELMDEEDVLQECKAQNRKLIEFLLKSECLEDLVSFIIEEPPQDMDEKIRYKYPNISCELLTSDVSQINDRLGEEESLLMKLYSFLLNESPLNPLLASFFSKVLSILISRKPEQIVDFLKKKHDFVDLVIKHIGTSAIMDLLLRLLTCIEPPQPRQEVLNWLNEERIIQRLVEIVHPSQDEDRHSNASQSLCEIIRLSRDQMLQVQNSSEPDPLLASLEKREIIEQLLSNIFHKEKNESAIVSAIQILLTLLETRRQTFEGHIEMCPPGMSNSAYSVNKSVLEAIKARLSSFHELLLEPPKKSVMRTTWGVLDPPVGNTRLNVIRLISSLLQTNTSSVNQELIELNSIGVILDMFFKYTWNNFLHTQVEICIALILASPLESTENGTITDQDSTGDNLLLKHLFLKCQLIERILEAWEMNEKKQAEGGRRHGYMGHLTRIANCIVHSTDKGPNSTLVQQLIKELPEEVRERWETFCTSSLGETNKRNTVDLVTTCHIHSSSDDEIDFKETGFSQDSSLQQAFSDYQMQQMTSNFIDQFGFNDEKFADQDDIGNVSFDRVSDINFTLNTNESGNIALFEACCKERIQQFDDGGSDEEDIWEEKHIAFTPESQRRSSSGSTDSEESTDSEEEDGTKQDLFESHASTEDKMEVDLNEPPNWSANFDVPMETAHGTNLDSVGSDVWSTEEPMPAKETGWASFSEFTSSLSSTDSLRSNSPVEMETNTEPMDPLSANASGLAAQLETPGSVAMEASSDGEEDAENADKVTETVMNGSMKETLSLTVDAKTETAVFKSEEGKLSTSQDASCKYVVEENAEVAEEAPSALQPANSSPEQRTDQRTLLGETSVNGPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YG81</accession>
    <name>A0A8C2YG81_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Tensin 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">TNS3</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Focal adhesion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PTEN phosphatase protein family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSCJPT00005033118.1">
        <property type="protein sequence ID" value="ENSCJPP00005024278.1"/>
        <property type="gene ID" value="ENSCJPG00005018731.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156328"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01213">
        <property type="entry name" value="PTB_tensin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14561">
        <property type="entry name" value="PTP_tensin-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09927">
        <property type="entry name" value="SH2_Tensin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000039">
        <property type="entry name" value="Tensin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000002">
        <property type="entry name" value="Tensin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000010">
        <property type="entry name" value="tensin-1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013625">
        <property type="entry name" value="PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035012">
        <property type="entry name" value="Tensin-like_SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014020">
        <property type="entry name" value="Tensin_C2-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029023">
        <property type="entry name" value="Tensin_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033929">
        <property type="entry name" value="Tensin_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051484">
        <property type="entry name" value="Tensin_PTEN_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45734">
        <property type="entry name" value="TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45734:SF5">
        <property type="entry name" value="TENSIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08416">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10409">
        <property type="entry name" value="PTEN_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22785">
        <property type="entry name" value="Tc-R-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01326">
        <property type="entry name" value="PTEN_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51182">
        <property type="entry name" value="C2_TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51181">
        <property type="entry name" value="PPASE_TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0965">Cell junction</keyword>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="858"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatase tensin-type" evidence="16">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="15">
        <location>
            <begin position="82"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="C2 tensin-type" evidence="17">
        <location>
            <begin position="175"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="14">
        <location>
            <begin position="1118"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="domain" description="PID" evidence="13">
        <location>
            <begin position="1259"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="356"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1039"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="386"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1050"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1061"/>
            <end position="1076"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005024278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1382" mass="151955" checksum="415CABE04081D175" modified="2022-01-19" version="1">MEEGYELDLTYITERIIAVSFPAECSEETYLHNLQDVTRMLKSKHGNNYLVLNLSEKRYDLTKLNPKIMDVGWPDLHAPPLDKVCTICKAMESWLNSDPQHVVVIHCKGGRGRIGVVISSYMHFTSVSTSADQALDRFAMKKFFDDKVSALMQPSQKRYVQFLSGLLSGSVKMNTASLFLHYVILHGIPSFDAGGACRPFLKLYQATQPVYTSGIYVESENQNRICIAIQPAQLLKGDVMLKCYHKKYRSATRDVIFRLQFHTGAIQGYGLVFGKEDLDSANKDDRFPDNGKVELVFSGSPEKIQGCEHLQNDHGVVVDHNTSDPLIRWDSYENMSSDGEVPHTQGPIDGSLYAKVRKKSSSDSSIPGVAQGIPVTNSPDHRDHTLSVSSDSGHSTASIRTDKTEERLMPGAKRVLSPQEKAELDKLLSGFGLEESIITTRSVTDAGSKYSGTHHIVPAQIHVNGDTKLKDRETDILDDEMPTHDLHSVDSIGTLSSSEGQHSTHLGNLSCPKSSQNSLLSDGFGSNTGEDHHNAIAPDLGIGVDPLYERSFGNTELKSSHQLQRNPCVSPPPQAYNPSNYSTHTWVCQQQMVTAHQYGFVSQNEMRVGILKTGENLGIAQSQSQVPDMLTHGSSSKGVVQRGLGSIPGIAECAEPADNESFKSELVPQRDINSQNLGPNAGDLPASPTLDIDQSIEQLNRLILELDPTFEPIPTRINNVTRETSQANGFTTQVVLSLVLAFRDWDPGKRRTDQLNDWLHGWNRKLSVGQYDNDFPGQSLYSGCGWMKPLVTDQAVNPGSLIPLGETEEMSVACYQDEIYGGIFSLARNGNEGVPSTPAFSLSPETPYGKEMFSSTSFFILIKMICLFYFCVQFLSLFFFFFFFFFDSPLAAEHSWTENSPKSSKLFQLSIGSNRPTGSYHVPSEFSNSVQDGSLLSHFQTPGLQAVTLSNLEKSPAEQQHEPAVSNSAQPYRSYNGANVGISSPQEEKEATFIANTSISSKTMSSPVESAEDEGFLAQNFLAMTSGHISQNNAVHPCLGGNLHSQPPLPEKKRSSEGDRSFISISPSSSGFSSPHSGSTISIPFPSVLPDFSNTLNTSLVPGRFLTVKFVQDTSKFWYKPVISREQAIAVLKDKEPGSFVVRDSHSFRGAYGLAIKVATPPPSVLQMNKKVGDLSNELVRHFLIECSQKGVHLKGCPNEPCFGSLTALVYQHSITPLALPCKLLIPNRDPLEEMAETSPQTAANSATELLKQGAACNVWYLNSVEMESLTGYQAVQKALSLTLMQDPSPISTIVHFKVSAQGITLTDNQRKLFFRRHYPVNTVIFCALDPQDRKVFGFVARKQGSGTDNVCHLFAEHDPEQPASAIVNFVSKVMIGSQKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YGQ8</accession>
    <name>A0A8C2YGQ8_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Orosomucoid 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ORM2</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the calycin superfamily. Lipocalin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015734590.1">
        <property type="nucleotide sequence ID" value="XM_015879104.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YGQ8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005034390.1">
        <property type="protein sequence ID" value="ENSCJPP00005025263.1"/>
        <property type="gene ID" value="ENSCJPG00005019852.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107321786"/>
    <dbReference type="KEGG" id="cjo:107321786"/>
    <dbReference type="CTD" id="5005"/>
    <dbReference type="GeneTree" id="ENSGT00390000012130"/>
    <dbReference type="OrthoDB" id="9393849at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006953">
        <property type="term" value="P:acute-phase response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002682">
        <property type="term" value="P:regulation of immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001500">
        <property type="entry name" value="A1A_glycop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000566">
        <property type="entry name" value="Lipocln_cytosolic_FA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11967">
        <property type="entry name" value="ALPHA-1-ACID GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11967:SF2">
        <property type="entry name" value="ALPHA-1-ACID GLYCOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00061">
        <property type="entry name" value="Lipocalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036899">
        <property type="entry name" value="AGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0011">Acute phase</keyword>
    <keyword evidence="7 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034822035" evidence="11">
        <location>
            <begin position="19"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Lipocalin/cytosolic fatty-acid binding" evidence="12">
        <location>
            <begin position="40"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="22"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="89"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR036899-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005025263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="199" mass="22234" checksum="32A85CCD199A1F89" modified="2022-01-19" version="1">MLAFLILTMGLLPAHTTGSPTCTPLVPADMDNATVNRLLGHWVYIMGASQYPPHMAEMKELKYATFTLFPGRNEDEFNVTEIMRLNETCVVRNTSKIHVYRHNSTLAHEEGQEVSMAELIHSDKDLFILKHFKDNHVGLSLSARTAEVTKEQLEEFEAQLRCHGFKLEEAFITSPKDACPEAGEEMGEGSTATAEPRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YHQ8</accession>
    <name>A0A8C2YHQ8_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Dynein axonemal intermediate chain 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">DNAI2</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein intermediate chain family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2YHQ8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005037056.1">
        <property type="protein sequence ID" value="ENSCJPP00005027412.1"/>
        <property type="gene ID" value="ENSCJPG00005021256.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163996"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036157">
        <property type="term" value="C:outer dynein arm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045503">
        <property type="term" value="F:dynein light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036158">
        <property type="term" value="P:outer dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000584">
        <property type="entry name" value="Dynein intermediate chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050687">
        <property type="entry name" value="Dynein_IC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442:SF7">
        <property type="entry name" value="DYNEIN AXONEMAL INTERMEDIATE CHAIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442">
        <property type="entry name" value="DYNEIN INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0243">Dynein</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="259"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="522"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="562"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="522"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="562"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="596"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005027412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="655" mass="74643" checksum="EC473D0DD9F64528" modified="2022-01-19" version="1">MEITHVYARTRREFGRYCNFSDSPTQVCVDIQPDPSLADNFVLRDPVDACVQHSSVLAEHEANTERVEVENRGVNHVEGGWPKDLNAQEPEQTLRFRKKVEKEENYVNTIIHLGELMEHCVKQNNAVNIYEQYFTEEEADEFEYEAPSAKTVNVIRDPNEIKRAATHLSWHPDKGRKVAVAYCSLEFQQSEEDMSFDSYIWDLVNCNKPEVVLKPSSPLVCLKYCPKDSNILVGGCYNGQIAYWDLRKGRLPVEVSTVEASHRDPVYSAIWLQSKTGTECFSGSTDGQVLFWDIRKLSEPTEILILDITRQGQLENALGASTLEYESTLPIKFMVGTEQGIIISCNRKAKTPPEKISSTYRGHLGPIYALCRNPFFPKFFLSVGDWTARIWSEDAKESSIMCTKYHLSYMTAGCWSTVRPAVFFTTKMDGTLDIWDFLFKQNNPSLSLKICDEPLSCLSLQDNGCVVGCGSKLGTITLLEISSGLCTLQKNEKNLANAMFERETKREKILEARHREMRLKERAKSEGHVVMEETPDESPQDIFDRTQKEFFEVIEAELQRRARAEAQQSDSKKVKEHAEEEVVAPGEEIELPKFEGEEEEEDEKEEKEEKKEEKEEKEEKEEKEAAKVNLNHPHIALPLPVGVVLVGWCRDGAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SKF1</accession>
    <name>A0A8C2SKF1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycogen debranching enzyme</fullName>
            <ecNumber evidence="5">2.4.1.25</ecNumber>
            <ecNumber evidence="6">3.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Glycogen debrancher</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">AGL</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>Hydrolysis of (1-&gt;6)-alpha-D-glucosidic branch linkages in glycogen phosphorylase limit dextrin.</text>
            <dbReference type="EC" id="3.2.1.33"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan to a new position in an acceptor, which may be glucose or a (1-&gt;4)-alpha-D-glucan.</text>
            <dbReference type="EC" id="2.4.1.25"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="19">Monomer. Interacts with NHLRC1/malin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the glycogen debranching enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.25" evidence="5"/>
    <dbReference type="EC" id="3.2.1.33" evidence="6"/>
    <dbReference type="RefSeq" id="XP_015725589.1">
        <property type="nucleotide sequence ID" value="XM_015870103.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015725590.1">
        <property type="nucleotide sequence ID" value="XM_015870104.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015725591.1">
        <property type="nucleotide sequence ID" value="XM_015870105.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005000201.1">
        <property type="protein sequence ID" value="ENSCJPP00005000093.1"/>
        <property type="gene ID" value="ENSCJPG00005000148.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107317427"/>
    <dbReference type="KEGG" id="cjo:107317427"/>
    <dbReference type="CTD" id="178"/>
    <dbReference type="GeneTree" id="ENSGT00390000012596"/>
    <dbReference type="OrthoDB" id="10248904at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016234">
        <property type="term" value="C:inclusion body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004134">
        <property type="term" value="F:4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004135">
        <property type="term" value="F:amylo-alpha-1,6-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd11327">
        <property type="entry name" value="AmyAc_Glg_debranch_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000070">
        <property type="entry name" value="GDB1p Glycogen debranching enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000039">
        <property type="entry name" value="Glycogen debranching enzyme Gdb1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000051">
        <property type="entry name" value="glycogen debranching enzyme isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010401">
        <property type="entry name" value="AGL/Gdb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032788">
        <property type="entry name" value="AGL_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029436">
        <property type="entry name" value="AGL_euk_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032792">
        <property type="entry name" value="AGL_glucanoTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032790">
        <property type="entry name" value="GDE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006421">
        <property type="entry name" value="Glycogen_debranch_met"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01531">
        <property type="entry name" value="glyc_debranch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10569">
        <property type="entry name" value="GLYCOGEN DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10569:SF2">
        <property type="entry name" value="GLYCOGEN DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06202">
        <property type="entry name" value="GDE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14701">
        <property type="entry name" value="hDGE_amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14702">
        <property type="entry name" value="hGDE_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14699">
        <property type="entry name" value="hGDE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="16" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Eukaryotic glycogen debranching enzyme N-terminal" evidence="21">
        <location>
            <begin position="31"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Glycogen debranching enzyme glucanotransferase" evidence="22">
        <location>
            <begin position="121"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="Glycogen debranching enzyme central" evidence="23">
        <location>
            <begin position="695"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="domain" description="Glycogen debranching enzyme C-terminal" evidence="20">
        <location>
            <begin position="1071"/>
            <end position="1525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00020723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00025780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00031477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00063438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF06202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF14699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF14701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF14702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005000093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1530" mass="174251" checksum="A64455DEE828B2E1" modified="2022-01-19" version="1">MVSHKETRLLHLNEMEKLDKTLFRLEQGFELQFRLGPTLQGKNVTVCTNYPASGEVFDRHKFRTLSWHNPTGKEDDSDKYCKLDLQISGSYQYYFSLGNEKSGGGYIVVDPILRVGADNHVLPLDCVTLQTFLAKCLGPFHEWESRLKVAKETGYNMIHFTPLQKLGMSRSCYSLADQLEVNPDFSSHNKKCTWNDIGALVEKMKNEWNMLCITDVVYNHTAANSEWLRMHPECGYNLVNSPHLKPAWVLDRALWHLSCMVADGRCIDKGVPPLIENDHHLNCIRKIIWEDIYPKIKLWEFFQVDVNKAVQQFRTLLTKGKIGTKSDPNQHLQIVQDPDYRRLGCTVDMNIALATFIPHSNGPGAIEECCNWFRKRIEELNAEQYRQIHHHQEQAVNCLAGTVVYERLAGHGPKLGPVSRKYPLVTRYFTYPFKDLTLEEEQSMMHQPDKACYFMAHNGWVMGDDPLRNFAEPGSNVYLRRELICWGDSVKLRYGNKPEDCPYLWAHMKKYTEITARNFHGVRLDNCHSTPIHVAEEMLATARSVRPNLYVVAELFTGSEYIDNVFVNRLGITSLIREAMTAYNSHEEGRLVYRFGGEPVGSFVQPRLRPLVPAIAHALFMDITHDNECPIQHRSAYDALPSAMIVSMACCATGSTKGYDELVPHQISVVSEERFYSTWNPQALLNSGEVNFQTGILAGRLAMNRLHQELGTKGFNQVYVDQVDEDIVAVTRHCPNTHQSVVAVSRTAFRDPKTSFYSKEVPEMFIPGKIEEVVFEARTIERNVSPYKKDEHFINGLPNFTVELREHIQIKDSKIIKQAGTAIKGPNEFVQEIEFENLTPGSVIVFRVSLDPKAQEAVGVLRNHLIQFSPHFKSGSLPDDHSAPILKTLFSSIASKLTLADLNQVLYRCESEEQEDGGGCYNIPNWSSLKYAGLQGLMSVMADIRPKNDLGHPFCDNLRSGDWMIDYVSNRLISRAGACAEVGKWLKAMFVYLKKIPRYLIPCYFDAILVGAYTTLLDVGWHQMSSFVQNGSTFVKHLSLGSIQMCGIGKYACLPDLSPSLHDVPYRLNEITNEKEQCCVTLAAGLPHFSSGIFRSWGRDTFIALRGLMLLTGRYIEARNIILAFGGTLRHGLIPNLLGQGTHARYNCRDAVWWWLQCIQDYCKIVPNGLDILRCPVSRMYPRDDSPPQPAGTVDQPLYEVIQEVMQRHMEGINFRERNAGPQIDQNMRDEGFNIVAGVDQETGFVFGGNRFNCGTWMDKMGESDRARNKGIPATPRDGSAVEIVGLCKSAVRWLLDLSRKNEYPFHGVTIKRNGREETITYDEWNRKIQGHFERLFFVSENPADPNEKHPNLVHKRGIYKDSYGASSPWCDYQLRPNFTIAMVVAPELFSPERAWKALKIAEEKLLGPLGMKTLDPDDMVYCGVYDNALDNDNYNVARGFNYHQGPEWLWPIGYFLRAKLYFSKLIGPEIYAKTVVMIKNVLSRHYVHLERSSWKGLPELTNENGQYCPFSCETQAWSIGVILEILYDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SP62</accession>
    <name>A0A8C2SP62_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Adenylate kinase isoenzyme 6</fullName>
            <shortName evidence="9">AK6</shortName>
            <ecNumber evidence="9">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Coilin-interacting nuclear ATPase protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Dual activity adenylate kinase/ATPase</fullName>
            <shortName evidence="9">AK/ATPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">AK6</name>
        <name evidence="9" type="synonym">CINAP</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. Involved in the late cytoplasmic maturation steps of the 40S ribosomal particles, specifically 18S rRNA maturation. While NMP activity is not required for ribosome maturation, ATPase activity is. Associates transiently with small ribosomal subunit protein uS11. ATP hydrolysis breaks the interaction with uS11. May temporarily remove uS11 from the ribosome to enable a conformational change of the ribosomal RNA that is needed for the final maturation step of the small ribosomal subunit. Its NMP activity may have a role in nuclear energy homeostasis. May be involved in regulation of Cajal body (CB) formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer and homodimer. Interacts with small ribosomal subunit protein uS11. Not a structural component of 43S pre-ribosomes, but transiently interacts with them by binding to uS11. Interacts with COIL (via C-terminus).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
            <location evidence="9">Nucleoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
            <location evidence="9">Cajal body</location>
        </subcellularLocation>
        <text evidence="9">Displays widespread diffuse nucleoplasmic distribution but not detected in nucleoli. Detected in Cajal bodies but not in all cells.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the adenylate kinase family. AK6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="9"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2SP62"/>
    <dbReference type="Ensembl" id="ENSCJPT00005001933.1">
        <property type="protein sequence ID" value="ENSCJPP00005001121.1"/>
        <property type="gene ID" value="ENSCJPG00005001190.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000015930"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome Z"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015030">
        <property type="term" value="C:Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Adenylate kinase isoenzyme 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00039">
        <property type="entry name" value="Adenylate_kinase_AK6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020618">
        <property type="entry name" value="Adenyl_kinase_AK6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595:SF0">
        <property type="entry name" value="ADENYLATE KINASE ISOENZYME 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595">
        <property type="entry name" value="POS9-ACTIVATING FACTOR FAP7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13238">
        <property type="entry name" value="AAA_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="2 9" id="KW-0690">Ribosome biogenesis</keyword>
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    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034605611" description="Adenylate kinase isoenzyme 6" evidence="10">
        <location>
            <begin position="20"/>
            <end position="175"/>
        </location>
    </feature>
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        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
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        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
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        </ligand>
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        </location>
        <ligand>
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        </location>
        <ligand>
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        </ligand>
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        <location>
            <position position="113"/>
        </location>
        <ligand>
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            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="HAMAP-Rule" id="MF_03173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005001121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="175" mass="20119" checksum="0E9D03E8A19DDC5A" modified="2022-01-19" version="1">MAVCLTLCACLSLGTPGVGKSTLGKELASRTGLTYISVGDLAKEEELYDGFDEEYECPILDEDRVIDELEDKMSEGGVIVDYHGCDFFPEHWFHIVFVLRTDNSFLYDRLESRGYKGKKLQDNIQCEIFQTLYEEAMLSYSKEIVHQLPSNTPEDLERNVDQIVQWIEQWSKDNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Coturnix japonica</name>
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            <taxon>Aves</taxon>
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        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
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                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    </dbReference>
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        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005001205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="85" mass="9724" checksum="07E9CF7DC61BAD64" modified="2022-01-19" version="1">TQRLLVNITGLVLHAQTFSEGASAMSFAELLHCFVRLILLDSYFLRLMLKIYFTTILDLPIYTSELFDIIQCSLCALAFHFTNTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SQ62</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
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                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
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                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <property type="protein sequence ID" value="ENSCJPP00005002146.1"/>
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        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
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            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005002146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="140" mass="14950" checksum="E75035393576B996" modified="2022-01-19" version="1">KAAQDPQMPISHVVLWARLGSGLPESCMLMCGSATGGGWEGVGNVAGMGAGLWVLGAHTGFWKLMLGSGLWILSVGFWVLSLGFWMLSSECWLLGVGFWVLGSEYWVLEAELRVLGSGCSFLSIGFWALDSGCWVLDAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SQK4</accession>
    <name>A0A8C2SQK4_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Zinc finger protein 845-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC107312446</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SQK4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005004186.1">
        <property type="protein sequence ID" value="ENSCJPP00005002324.1"/>
        <property type="gene ID" value="ENSCJPG00005002519.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161979"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001370">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408:SF61">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE ZNF451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="426"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="455"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="561"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="589"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="617"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="663"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="828"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="856"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="954"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="982"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="1054"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="1082"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="288"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="478"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="295"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="321"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="478"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="497"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005002324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1157" mass="132201" checksum="59E1060D90FEFF5A" modified="2022-01-19" version="1">MTVRSERVTKPAPTSSWAHPFNAGSPRPPLRPMGRRQPRPFLRKLRCVRAQWSRGGRRVLCAGVAVAAGVGLRMAVSVEQAMLEEEVNESEVLEILLPVTVFVLSDDEFLQVQEQAMLVPELMEEKQEVVGSCCLSEGGLRPLCDSEGLDVWEEHSGTANQNGSTQYTEEEWIPESMCNNSKLTISNGISKDEQSHSAAVPTSPCQTELAKMSKVSGRKECNDNDAIPKIPLLCAADSEDRDKTTDHLVLPAVCGDEELSCVPGVLNDESQEKQPQVHEEMGTALEVEDADSLQNGNNDTNGKTNKGSKSEDETPGSVLQHDFKEGPELDSDRFIHRGSTSELQKDGGKPESNASISAVSATPEEHIYKSLTPFSKKRCRRRRIISSRESETKGQQEDLAWLSNSMNIKPLPKASCSTNKRGKIHFNCKFCSSVYKSSALLKRHVYLAHKKKRKHKCSFCKKTFFFAVNLKKHLKLHKTAKLQKERKNRMSARKVRQRTEERKSERKKRESKYEKYFMKMERDFTSLGVPVIFSCKTCYFDSSNPKTFIHHMRAHKERPPYWCPQCDYSSSSLSYLLNHMYWHAGYKLYKCRFCTFFSLYFSSMVKHSYMHAGPKPYSCEYCQSTFTSINGLKRHRRLHVSEETCKVDFGNGRKRTRRSSKSYACDECNVLFYSRGHLNSHKKCHKQHKVSANGYMNQSSEYRKSKRCKIESDSKGCVPVPLSDEDDDLAGGVCKTLVPEIDFVRAGDVQGSKKRCPRRAFTKNSHVRNIAPIFGGRSEVLDLYKMDTVVYKEDPETSHSQIQDTKNSGSYYKPEGMWPSSLSMFKLYKCKHCDYATTVHSSYKQHLKVHTKKGPFVCQECNKTYKTSNRLQRHRQLHVKDEYEVSHYFYADSHLDNHGFHHEMQVGTYPERDFGSSQGFSGVCSMLASETYGEQADTKRDIDDLLSQSQPRFYQCVECEYSTYVLSSLRLHIRTHTGEKPYSCSVCQKEFRTSSHLKRHQVLHCNTEHFKCRKCDYSTNKWLSLKQHLASHAVNESSSADYIYEQNTLPVKTYTCEECGYTTFHSGNFKQHRRIHTGEKPFKCGQCGVAFRTSGHLKRHLLTHVKFHCSSAVNLFLVEAELEMEAPLHACVAVLFCKVRITYILQHEQFSATYFCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SQP7</accession>
    <name>A0A8C2SQP7_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SQP7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005004272.1">
        <property type="protein sequence ID" value="ENSCJPP00005002374.1"/>
        <property type="gene ID" value="ENSCJPG00005002557.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000003292"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039146">
        <property type="entry name" value="GPANK1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20923">
        <property type="entry name" value="BAT4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20923:SF1">
        <property type="entry name" value="G PATCH DOMAIN AND ANKYRIN REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="580"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="580"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005002374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="599" mass="64880" checksum="AA7902618EBAB0D0" modified="2022-01-19" version="1">MLRWIEFQRAREPLSGWKDGVKAPPEPETQPDTDKELEAGREARRFYESLLREELPSSRPTPEVRPTPPEVRPTAPEVRPTPPEVRPARPKVRPTLPKARPTPPEVRPTPPEAPPPPKRRHFPPPLDAVTRERRGHAMLKAAQDGDMAALRRMVEKEGGDVHFRDHFRWSAVMCAARAGRVQAVRYLLEHGAHGGEPARTLAEMGGHWDVVRVINEWGETGNMADKNKMAAGNKMAAGSKMADRSKMDDGNKMADKNKMAAGSKMADRSKLDIGNKMADGNKMADRSKMADGNKMACKKKMAAGSKMADRSKMDDGNKMAAGNKMGDGNKMAAGNKMADRSKMDDGNKMAARNKMAAGNKMADRSKMADGNKMANKNKMAAGNKMADKNKMAAGNKMADGAMMAASGKMVDGGKMVDGDKMEDGNTMVDGGKMAAKEDKMAAMKDVEVEEEESKMAAHWLPRCRCPFKASPSHIMCRCPFKAAPSHIMCRCPFKASRLHISSASSLRPPRPFTPLYGGGSPLSPLPPPLFNPTNVFPAVHFRGGVGPLRGGFGAGGGGVRQPSKNEAEMGLKGGWLWGGGQSQGHPFWGGGRQSQSGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SQZ2</accession>
    <name>A0A8C2SQZ2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL49</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">39S ribosomal protein L49, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL49 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SQZ2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005004483.1">
        <property type="protein sequence ID" value="ENSCJPP00005002435.1"/>
        <property type="gene ID" value="ENSCJPG00005002685.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007740">
        <property type="entry name" value="Ribosomal_mL49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13477:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13477">
        <property type="entry name" value="MITOCHONDRIAL 39S RIBOSOMAL PROTEIN L49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005002435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="106" mass="11790" checksum="2A6D914DDB9D492D" modified="2022-01-19" version="1">MGRIGGPNMRVPPPIYSQTPPGDPPPYPAVVECTEDFHYVERLLPPACIPAPPQHQSYPTPSGWTPPREPPPSLPYHMGYPPINAYYPPIMGLYIWIEGAMNIQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SR72</accession>
    <name>A0A8C2SR72_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane protein 174</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">TMEM174</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SR72"/>
    <dbReference type="Ensembl" id="ENSCJPT00005003394.1">
        <property type="protein sequence ID" value="ENSCJPP00005001950.1"/>
        <property type="gene ID" value="ENSCJPG00005002042.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000004161"/>
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        <property type="component" value="Chromosome Z"/>
    </dbReference>
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        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055062">
        <property type="term" value="P:phosphate ion homeostasis"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027835">
        <property type="entry name" value="TMEM174"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31020">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31020:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15029">
        <property type="entry name" value="TMEM174"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005001950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="239" mass="25961" checksum="56DBC778EC83BB15" modified="2022-01-19" version="1">MEQNNSNVEDFSLNVFSVSPYPPSRSDALVSDGDKAGATLLFSGVFLGLVGITFTVMGWIKYDGLTHLEWTQLLGPILLSVGVTFILIAVCKFNMLTCKPCKEREENMLDIDQSTSGQSFVFTGINQPITFHGATVVQYIPPPYPALDSGATSPGYLHPVLSCCGAVSPGVSPIPSPSSAHFCPAYSLDNPAFTWDESCASYLTENTRNQSSDEPEELLEDPCEELSPPRYEEIYPLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SR86</accession>
    <name>A0A8C2SR86_COTJA</name>
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        <recommendedName>
            <fullName evidence="4">6-phosphofructo-2-kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SR86"/>
    <dbReference type="Ensembl" id="ENSCJPT00005004688.1">
        <property type="protein sequence ID" value="ENSCJPP00005002543.1"/>
        <property type="gene ID" value="ENSCJPG00005002815.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183084"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003873">
        <property type="term" value="F:6-phosphofructo-2-kinase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006003">
        <property type="term" value="P:fructose 2,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:006182">
        <property type="entry name" value="6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003094">
        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013079">
        <property type="entry name" value="6Phosfructo_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606:SF15">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE_FRUCTOSE-2,6-BISPHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01591">
        <property type="entry name" value="6PF2K"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="4">
        <location>
            <begin position="7"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005002543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="69" mass="7636" checksum="80938596855E8E69" modified="2022-01-19" version="1">PPPPQIATVPQFTNCPTMVILVGLPARGKTYISRKLTRYLNWIGMPTRGEYHGGLWGLYGDLCGLYGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SRN2</accession>
    <name>A0A8C2SRN2_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Reeler domain containing 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">REELD1</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SRN2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005003062.1">
        <property type="protein sequence ID" value="ENSCJPP00005001807.1"/>
        <property type="gene ID" value="ENSCJPG00005001844.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163277"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08544">
        <property type="entry name" value="Reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4060">
        <property type="entry name" value="Reeler domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051237">
        <property type="entry name" value="Ferric-chelate_Red/DefProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002861">
        <property type="entry name" value="Reeler_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042307">
        <property type="entry name" value="Reeler_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45828">
        <property type="entry name" value="CYTOCHROME B561/FERRIC REDUCTASE TRANSMEMBRANE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45828:SF51">
        <property type="entry name" value="REELIN DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02014">
        <property type="entry name" value="Reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51019">
        <property type="entry name" value="REELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Reelin" evidence="3">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="235"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005001807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="488" mass="52280" checksum="64B33AC1F7D7956A" modified="2022-01-19" version="1">MEIPSQKNHLRTTAQIPVCAMFCLAVTVRSSRDFMGFLLQARKTSNDETAGTFVFIPPGSKLLSCFEDGDTVTHSDKSLKRNLSFVWKAPDQPIGDIKFFISVVQSYFVYWARIESTTVAQRGHSDTSAGGSRKAGPAAPAPTQEPASPHMAGTASKAAGEISDGREELPEEKAQMGILGTGSSIANPSSLEYTSPALVSLAGITPTPVLGSGTGVHSDMQPTAEPTQLSQTLWSGGSSPRSSSGLEPSLAFQEPGMADALQSFLFQDYASRQSLPDRAQSTASITNPHPCVTCKEEGQASTENGATPETSLTAAASWSALHIHSHLSKAAVTTAWFSNEDTVSNLSLAWRQMAESKPPRQPQEEEVSEEVGGHTLPWVTRAGPKPAVPGKGDDSRRGTRLIAAQLGILLVCTVVLGLAAAAGLRYICARYCHKRTEVSFSEPGNNVIAIKDNGEMMHFRKIRENSFVLVQAEYNWISPSSSGKRRIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SRV3</accession>
    <name>A0A8C2SRV3_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NIDO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SRV3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005005248.1">
        <property type="protein sequence ID" value="ENSCJPP00005002861.1"/>
        <property type="gene ID" value="ENSCJPG00005003143.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00730000110943"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051495">
        <property type="entry name" value="Epithelial_Barrier/Signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003886">
        <property type="entry name" value="NIDO_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13802">
        <property type="entry name" value="MUCIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13802:SF59">
        <property type="entry name" value="SUSHI DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06119">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00539">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51220">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NIDO" evidence="2">
        <location>
            <begin position="124"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005002861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="357" mass="38925" checksum="19041A00E3A934DD" modified="2022-01-19" version="1">MGTMGDLWGPIGPYRGQWGSIGPYRDIGVTVFPLYPEGGPISASRSQKGSVLYPFGYGVGDATTPHEDDGMSPEIPLTETFSFYGRPYRSLYVNNNGVVSFGTGVPEFTPHPFPLDGHRPFVAPYWADVDTRLGGDVFYRETRDPNVLNRVRRDIDPITDPIEPDPKPTWAFIATWDRVPFYGAASNKVNTFQAVLATNGVTSFIILNYGDIEWTTGIANQGDPHTGLGGIPAQAGFNSGDDVHYYNIPGSRTAAILRINQTSNVGIRGRWVFRVDEFTATEGPPGSPPDPITGPQNPIEDPITVPGPITGPQNPIEDLITVPDPITGPQNPIEEPINNGVGQEPEENGEREYICQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2STC0</accession>
    <name>A0A8C2STC0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Zinc finger and BTB domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">ZBTB1</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Acts as a transcriptional repressor. Represses cAMP-responsive element (CRE)-mediated transcriptional activation. In addition, has a role in translesion DNA synthesis. Requires for UV-inducible RAD18 loading, PCNA monoubiquitination, POLH recruitment to replication factories and efficient translesion DNA synthesis. Plays a key role in the transcriptional regulation of T lymphocyte development.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015721116.1">
        <property type="nucleotide sequence ID" value="XM_015865630.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2STC0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005005166.1">
        <property type="protein sequence ID" value="ENSCJPP00005002802.1"/>
        <property type="gene ID" value="ENSCJPG00005003101.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107315342"/>
    <dbReference type="CTD" id="22890"/>
    <dbReference type="GeneTree" id="ENSGT00940000157501"/>
    <dbReference type="OrthoDB" id="8922241at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070530">
        <property type="term" value="F:K63-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030183">
        <property type="term" value="P:B cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034644">
        <property type="term" value="P:cellular response to UV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042789">
        <property type="term" value="P:mRNA transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032825">
        <property type="term" value="P:positive regulation of natural killer cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000176">
        <property type="term" value="P:positive regulation of pro-T cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002711">
        <property type="term" value="P:positive regulation of T cell mediated immunity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033077">
        <property type="term" value="P:T cell differentiation in thymus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048538">
        <property type="term" value="P:thymus development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019985">
        <property type="term" value="P:translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd18192">
        <property type="entry name" value="BTB_POZ_ZBTB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000109">
        <property type="entry name" value="zinc finger and BTB domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF42">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0221">Differentiation</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-0391">Immunity</keyword>
    <keyword evidence="4" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="14" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 18" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BTB" evidence="20">
        <location>
            <begin position="24"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="21">
        <location>
            <begin position="219"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="21">
        <location>
            <begin position="576"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="21">
        <location>
            <begin position="604"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="272"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="389"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="272"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="311"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00059022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00074852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005002802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="642" mass="74075" checksum="A73740AA10AFE56C" modified="2022-01-19" version="1">MARTSHSNYVLQQLNNQREWGFLCDCCIAIDDIYFQAHKAVLAACSSYFRMFFMNHQHTTAQLNLSNMKISAECFDLILQFMYLGKIMTAPANFEQFKVAMNYLQLYNVPECLEDIQDTDSSSLKCSSSASSTQNSKMIFGVRMYEDTLARNGSETNRWGMEPPSSTVNTSHNKEPDEEALQLSSFPEQLFDVCKKSTTSKYSHTKERVSHSRRFGRSFTCDSCGFSFSCEKLLDEHVLSCTNRHSYQSTRYYGAEKIDFNEKDSASKMISTQTDKYKGDSSQVADDSSSPVSNVTSRKSSTVASETSGEEGSRASERKRIVIKMEPEDSPADEMKDYNIIKVTDKDCNESSDNDDLDDEQEEPLYRYYVEEEMREKRNARKTLKPRLSMDEDERRCLKSPRHLSRKTPSVQEDVENAPCELCGLTITEEDLSSHYLSKHIENICACGKCGQILVKGKQLQDHAQTCGEPQDLTMNGIRNSEEKMDLEENPEEQSEIRDMMFADMLEDFRDSHFQMNSLQKKQLYKHSACPFRCPNCGQRFETENLAVEHMSNCLEQDLFKNSMMEENERDHRRKHFCNLCGKGFYQRCHLREHYTVHTKEKQFVCQTCGKQFLRERQLRLHNDMHKGMASSEIGTSKLLNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SU54</accession>
    <name>A0A8C2SU54_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphoribosyltransferase domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">PRTFDC1</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SU54"/>
    <dbReference type="Ensembl" id="ENSCJPT00005006680.1">
        <property type="protein sequence ID" value="ENSCJPP00005003850.1"/>
        <property type="gene ID" value="ENSCJPG00005003949.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162225"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004422">
        <property type="term" value="F:hypoxanthine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000038">
        <property type="entry name" value="Hypoxanthine phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050408">
        <property type="entry name" value="HGPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005904">
        <property type="entry name" value="Hxn_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01203">
        <property type="entry name" value="HGPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43340">
        <property type="entry name" value="HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43340:SF5">
        <property type="entry name" value="PHOSPHORIBOSYLTRANSFERASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="7">
        <location>
            <begin position="52"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00071775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005003850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="312" mass="35303" checksum="0A145685E688DA04" modified="2022-01-19" version="1">MAGHGGSSEAARGGGGRGVVISDDWPGYSLDLFTYPQHYYGDLEYVLIPHGIIVDRTERLAKDIMQDIGDNDIVVLCVLKGGYKFCADLVEHIKNLSRNSERFISMKVDFVRLKSYHNDQSMQDMQIMGGDDLSKLTGKNVLIVEDIVGTGRTMKVLLNHIEKYNPKMIKVASLLVKRTSWPDGYRPDYYGFEIPDLFVVGYALDYNEYFRDLNVSFFFLYKKTLFYRVLETVIYLIISVILCHAWILPVSVELLAKPQIIQRSLCTALWMVPSHLIATKSRSSHFIVHKLLSSVSLHGSTTPSECSDSSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SUF0</accession>
    <name>A0A8C2SUF0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase</fullName>
            <ecNumber evidence="6">3.1.3.86</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">INPPL1</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:25528"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57658"/>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
            <dbReference type="EC" id="3.1.3.86"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:25529"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.86" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2SUF0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005005545.1">
        <property type="protein sequence ID" value="ENSCJPP00005003067.1"/>
        <property type="gene ID" value="ENSCJPG00005003059.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156576"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004445">
        <property type="term" value="F:inositol-polyphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034485">
        <property type="term" value="F:phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042169">
        <property type="term" value="F:SH2 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001958">
        <property type="term" value="P:endochondral ossification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002376">
        <property type="term" value="P:immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043569">
        <property type="term" value="P:negative regulation of insulin-like growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050776">
        <property type="term" value="P:regulation of immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000005">
        <property type="entry name" value="phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057509">
        <property type="entry name" value="C2_SHIP1-2_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057510">
        <property type="entry name" value="C2_SHIP1-2_first"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46051:SF2">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 5-PHOSPHATASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46051">
        <property type="entry name" value="SH2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24147">
        <property type="entry name" value="C2_SHIP1-2_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24150">
        <property type="entry name" value="C2_SHIP1-2_first"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0391">Immunity</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 16" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="SH2" evidence="18">
        <location>
            <begin position="35"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="141"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="959"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1027"/>
            <end position="1063"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005003067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1141" mass="126673" checksum="885F39C5570D83EF" modified="2022-01-19" version="1">MRWKCMGSASVGLDGCPLVPCGFPGQVHGTKGKHMMLGSMGHGAPWDRHKATASLPKAGAQFLCLQSAHGADALLSRRFQRHVHTYRILPNSEGLLSVQSIQGIQAKCFRSLPELISAYQQPNNGLVTPLLYPVHRLREAANEDSDGEDGRGGHVGSVVPTRVNGGSTGPGAPPTHPHISQQLQLRLQEQVHSSPSSDFMGFMADYLAQHLPLDLATLCSGHPQLCHLSAALVTACQALHSEIDFTLAGLETLARVFEPPVSPRSPARDQGFLASNPDLELLLSKISAVNHLLSSLEKKVLMSVHDTVSWHNLELPSPAALPPDTKSMATQCFEVKVGKSQRTALMVDVEEGTVTITKRGSGSPEEVIPQDKILQLIKYQSMQSKVRLVYNRDMQRSLSKDIVFPSAKKREAFCQLLQLMKIQHSNLDEPDLISVYVGTWNMGSTPPPRSLASWLTSRGLGHTQDETTTCIPHDIYVIGTQENSLGDREWVEFLRASLKTLMAIDYQVVALQSLWSIKMVVLVKPEHKRRISHVHTSSVKTGIANTLGNKGAVGVSFLFNGTSFGFVNCHLASGSDKTHRRNQNYSDILRSLALGDKRLSAFDLTLRFTHLFWFGDLNYRLNMDVQDVLTHVTKKEFDILLAMDQLNLEREKNKVFLQFREGDISFPPTYRYERGSRDNYMWQKFKTTGMRINVPSWCDRILWKSLPETHLVCSSYGCTDDIVTSDHSPVFATFEVGVTSQFVPKKAPGTGPEPLACIEWDSIEVIVKTASRSKCYIEFHSYCLEEAQRSGENTSQSCDIPGFLRMCWSAKQLPVLNPILPDLEYLGDQHLLLSIKGIESCESYGECCIAMRSMIDSMAQKFETFLFHHGEETGSMRGWMKVRVPKDRHSTRERLYEWISFEEEEEEEDAPAEDSTLYPKPLLRSRPCSFPEATSSYTNPAYFIFEGLPATWALGADIQEDSPMRGPPQAQAPLPSPCRSLLSPPGVGRQKRPKSAVLVRDVPEGGDCSLTMLHMATSPNHLDRMAPRGEGGSHQMLLDQSHSAPQPPPPRYREVPGRGMSAHQHGHHKEWCCDKSCSAGTGPDHVGVQQHEEGLCAHGWNSAEVFRYPPALELAAAGTEQGSTCIPRVPSRALCLREDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SUJ0</accession>
    <name>A0A8C2SUJ0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">GABA(C) receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">GABRR2</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>chloride(in) = chloride(out)</text>
            <dbReference type="Rhea" id="RHEA:29823"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Postsynaptic cell membrane</location>
            <topology evidence="17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SUJ0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005006874.1">
        <property type="protein sequence ID" value="ENSCJPP00005004001.1"/>
        <property type="gene ID" value="ENSCJPG00005004055.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156864"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097708">
        <property type="term" value="C:intracellular vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004890">
        <property type="term" value="F:GABA-A receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007214">
        <property type="term" value="P:gamma-aminobutyric acid signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd19005">
        <property type="entry name" value="LGIC_ECD_GABAAR_rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19059">
        <property type="entry name" value="LGIC_TM_GABAAR_rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000007">
        <property type="entry name" value="Gamma-aminobutyric acid type A receptor rho2 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000005">
        <property type="entry name" value="Putative gamma-aminobutyric acid receptor subunit rho-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008059">
        <property type="entry name" value="GABAAa_rho2_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008057">
        <property type="entry name" value="GABAAa_rho_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01670">
        <property type="entry name" value="GABAARRHO"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01672">
        <property type="entry name" value="GABAARRHO2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0868">Chloride</keyword>
    <keyword evidence="10" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14 18" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 18" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 18" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 18" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034346229" description="GABA(C) receptor" evidence="18">
        <location>
            <begin position="21"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="449"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="19">
        <location>
            <begin position="61"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="20">
        <location>
            <begin position="268"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00024167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005004001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="467" mass="54327" checksum="BD5BCDA37D6AB734" modified="2022-01-19" version="1">MPHFAKLLLLIFCLVLLVESRKHRRRRWTSQLELQKAGHIYKKNHDVTKTRKGKTEQLLRVDDHDFTMRPAFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLSFPSTTNNSMTFDGRLVKKIWVPDVFFVHSKRSFIHDTTTDNIMLRVFPDGHVLYSMRITVTAMCNMDFSRFPLDSQTCSLELESYAYTDEDLMLYWKNGNESLKTDEKISLSQFLIQKFHTTSRLAFYSSTGWYNRLYISFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVSLGITTVLTMSTIITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQERKERKLREKFPCTCGMPHSKTMMLDGNYSESDANSLAGYPRSQMVPEEEKQEKMAVHLAMSNASNASNSSRKRGLKGHVGLRIIQNTHAIDKYSRLIFPGTYIFFNLIYWSVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SVQ8</accession>
    <name>A0A8C2SVQ8_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">EEF1A lysine methyltransferase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">EEF1AKMT3</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SVQ8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005007590.1">
        <property type="protein sequence ID" value="ENSCJPP00005004549.1"/>
        <property type="gene ID" value="ENSCJPG00005004477.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161297"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome LGE22C19W28_E50C23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF5">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005004549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="240" mass="26238" checksum="AD47224B5DDB2FB1" modified="2022-01-19" version="1">SGDGRKEEADEDGAESLPLSAVFPRDTELFSDTFPELKRFRFCGRVLRIAQHHGPRLGMAAAVWDGEQRMDFSGRTVIELGAGTGIVGILAAMLGGDVTLTDLPLALEQLRTNTELNAAAVAASRGRVRVQALPWGRALGSIPHSYDVVLGADVVYDPRCFPALLDTLLQLCGPRSVAFLSCGMRPQLGTAGFFWELLPVHFCVRLLRHHKDSDVGLYRVTRRRDSNGCSPIEQHGEQET</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SXW3</accession>
    <name>A0A8C2SXW3_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13">Tyrosine aminotransferase</fullName>
            <shortName evidence="13">TAT</shortName>
            <ecNumber evidence="5 13">2.6.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">TAT</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:15093"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:36242"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="EC" id="2.6.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13 14">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 2/6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.5" evidence="5 13"/>
    <dbReference type="RefSeq" id="XP_015729753.1">
        <property type="nucleotide sequence ID" value="XM_015874267.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SXW3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005006880.1">
        <property type="protein sequence ID" value="ENSCJPP00005004005.1"/>
        <property type="gene ID" value="ENSCJPG00005004053.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107319455"/>
    <dbReference type="KEGG" id="cjo:107319455"/>
    <dbReference type="CTD" id="6898"/>
    <dbReference type="GeneTree" id="ENSGT00940000156704"/>
    <dbReference type="OrthoDB" id="7042322at2759"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00338"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004838">
        <property type="term" value="F:L-tyrosine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006103">
        <property type="term" value="P:2-oxoglutarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006536">
        <property type="term" value="P:glutamate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000048">
        <property type="entry name" value="tyrosine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000040">
        <property type="entry name" value="Tyrosine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011715">
        <property type="entry name" value="Tyr_aminoTrfase_ubiquitination"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005958">
        <property type="entry name" value="TyrNic_aminoTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005957">
        <property type="entry name" value="Tyrosine_aminoTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01264">
        <property type="entry name" value="tyr_amTase_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01265">
        <property type="entry name" value="tyr_nico_aTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45744">
        <property type="entry name" value="TYROSINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45744:SF2">
        <property type="entry name" value="TYROSINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07706">
        <property type="entry name" value="TAT_ubiq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000517">
        <property type="entry name" value="Tyr_transaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="11" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="10 13" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="15">
        <location>
            <begin position="72"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="14">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR000517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000517-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005004005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="455" mass="50649" checksum="E58F42295E27AFBA" modified="2022-01-19" version="1">MDSYLIQVNGQGDHVPLLDIHLKTNGNSMSLGKMKGRKPRWAVRASEMSKKTFNPVRAIVDSMKVEPNPKKSVITLSLGDPTVFGNLPTNDEVTRAMKEALDSGRYNGYAPSIGYQSCREAVAAYYNCPEAPLEAQDVILTSGCSQAIELALAVLANPGQNILVPRPGFSLYKTLALSMGIEVKFYNLKPEKSWEIDLKHLESLVDEKTACIIVNNPSNPCGSVFSKSHLQKILAVASRQCVPILADEIYGDMVFADCKYEPIATLSTNVPILSCGGLAKRWLVPGWRMGWILIHDRRDIFGNEIRDGLIRLSQRILGPCTIVQGALEHILHRTPPDFYHNTLSILKSNADLCYAALSAIPGLQPVRPAGAMYLMVEIEMEHFPEFENDVEFTERLISEQSVFCLPATCFEYPNFFRVVITVPEEMILEACSRIQEFCEMHYQAAEGAQDLECDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SZZ6</accession>
    <name>A0A8C2SZZ6_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA (cytosine-5-)-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">DNMT3B</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.37" evidence="2"/>
    <dbReference type="RefSeq" id="XP_015737591.1">
        <property type="nucleotide sequence ID" value="XM_015882105.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SZZ6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005008981.1">
        <property type="protein sequence ID" value="ENSCJPP00005005546.1"/>
        <property type="gene ID" value="ENSCJPG00005005284.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107323238"/>
    <dbReference type="KEGG" id="cjo:107323238"/>
    <dbReference type="CTD" id="1789"/>
    <dbReference type="GeneTree" id="ENSGT00940000156928"/>
    <dbReference type="OrthoDB" id="641149at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902494">
        <property type="term" value="C:catalytic complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051718">
        <property type="term" value="F:DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd11728">
        <property type="entry name" value="ADDz_Dnmt3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20155">
        <property type="entry name" value="PWWP_DNMT3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000006">
        <property type="entry name" value="DNA (Cytosine-5)-methyltransferase 3B isoform 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.50">
        <property type="entry name" value="PWWP, helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025766">
        <property type="entry name" value="ADD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050390">
        <property type="entry name" value="C5-Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018117">
        <property type="entry name" value="C5_DNA_meth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040552">
        <property type="entry name" value="DNMT3_ADD_GATA1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049554">
        <property type="entry name" value="DNMT3_ADD_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030488">
        <property type="entry name" value="DNMT3B_ADD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23068:SF9">
        <property type="entry name" value="DNA (CYTOSINE-5)-METHYLTRANSFERASE 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23068">
        <property type="entry name" value="DNA CYTOSINE-5- -METHYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17980">
        <property type="entry name" value="ADD_DNMT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21255">
        <property type="entry name" value="DNMT3_ADD_GATA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00293">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51533">
        <property type="entry name" value="ADD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00094">
        <property type="entry name" value="C5_MTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PWWP" evidence="12">
        <location>
            <begin position="239"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="13">
        <location>
            <begin position="417"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="145"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="650"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005005546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="847" mass="94523" checksum="A8FA802CF0DA054E" modified="2022-01-19" version="1">MSMVTSLERLEQRLAVMVAAQETSQAWSSLGEEGPAAMKKEKSHSRDEADCRAELILFDEDCTDPTKDTAALLLEASGKPSDLDAGSLGLAPLKNKRVSKDLSKDELSWPLTLMEPQEVRPRGSSGWESSLRQKPPVRLIFQAGQGHHEMQMKESSSVEALRELPTPLRSSRRRTAVPMLTTIDLTEDDSRDSSQSSSTLSGSSSQEGQNGSTELVAEEPESRDAGIALEYQDGKEFGIGELVWGKIKGFSWWPAIVVSYRATSKRQAASGMRWVQWFGDGKFSEVSADKLVGLMAFRQHFNTATFHKLVSYRRAIYHALEVARSRSGKTFTSAPGESLEDQLKPMIDWALTGFKPLGVKGLQPPKISENGALRNGTEEVLCLEHCPPTKRLKSNLYNSSKEQRMEEDQTREQMVSEVTNNSGSLEDSCLSCGRRNPATFHPLFEGGLCHTCRDRFLELFYMYDEDGYQSYCTVCCEGKELLLCSNSSCCRCFCVECLEVLVGRGSSTKAKEQEPWNCYMCQPQRSYGVLQRRQDWSSRLQDFFTSDKGQEYDAPKIYPAVPPDKRRPIRVLSLFDGIATGYLVLKDLGIQVEKYIASEICEDPLAVGTVRHEGNITYVHDVRNITKRNIQEWGPFDLVIGGSPCNDLSLPSPPKKASYGEAAWPQGAGSPQASWGRRRSSAVAPSGDTCPGQPEPVPTPQPNLRGRGRSPPNTPAGSSPRTEGTGRLFFEFYHLLNYARPKAGEERPFFWMFENVVAMGVNDKRDISRFLECNPVMIDAIKISAAHRARYFWGNLPGMNRIFGFPLHCTDVSNISRGARQKLLGRSWNIPVIQHLFSPLKDYFACE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T006</accession>
    <name>A0A8C2T006_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Coiled-coil domain containing 146</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CCDC146</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T006"/>
    <dbReference type="Ensembl" id="ENSCJPT00005008995.1">
        <property type="protein sequence ID" value="ENSCJPP00005005559.1"/>
        <property type="gene ID" value="ENSCJPG00005005286.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063534"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036126">
        <property type="term" value="C:sperm flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120212">
        <property type="term" value="C:sperm head-tail coupling apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008283">
        <property type="term" value="P:cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905198">
        <property type="term" value="P:manchette assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006997">
        <property type="term" value="P:nucleus organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007338">
        <property type="term" value="P:single fertilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007288">
        <property type="term" value="P:sperm axoneme assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32083">
        <property type="entry name" value="CILIA AND FLAGELLA-ASSOCIATED PROTEIN 58-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32083:SF34">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="100"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="173"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="271"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="391"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="489"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="580"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005005559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="856" mass="100492" checksum="4353874E66F9FF85" modified="2022-01-19" version="1">SRVADLKAKYTLLHETVRSLQESEIQLLQEAKRLSVDLEQQQHELEKAEQFPEDSSSEVWRIRQQLLNCQNEYNWKKISYFIPCCKKCYHHSTSVNSVISEESNKAMKKMKEDCDELDKEVTQRKAEVNAVKEDILSKQELALIDKKEVEKLQEVQDSLKDELVKILGVPMQLKKEAEKINQKKINAEKTNEDLNNQMQELNSTLKDIDKGTEEILQEREVVMKELDGKRALMESRERECAALTKMLETGREKEMAILERILENKRQRETLIRMQIQKDKELKSLKKMEQQLNIIYDSLEQDKSHHKTLKVEVCINTLIIRIPKALAANISVYDIFGLIRAEGECIAEEGRLFKEQEKRRDELSRLARLTWLKVEEKEQKSREFQKVQMQFQNIIRELKRKDLEIEQHKKRKRRVQKQLRGAAKICEVIKNERNKCIHLLNIAQQKTTEIKEQIKVKASESETLRNTLMTQERELQKQHMKNKNNIAINESLRKDCSKVEKVMNDMNEKKKQNVMDLNGLTNIVTHVEEEIAQLHNKYKRAIEEKNESGLLLRSREEEVCILYEKINTQEFLCRKGDIELQAMDEKISFLKMKAAEIETQIKFWLKAIPMEKALDAELVVLQIQYSQCKDRIKEMEEIFVDPKNENRKRDLGGKDLSPPELRKKIEQLEEELVQKEEKLLETEMIYEHIVRLTDRIRATAENGQQGTMLLATRINELQQKIKDRTKKMMALVAELSMKQALAIKLHQEMRDREEFLMIVSSRIEQGLPPPKETEIEWLKVLRNEKMHKEAAEAREEAAVLGHVHTTAEPRPNAYVPDDAYSLPLPRPYGALAPFKPNEPGSNIRHFRKPIIKPIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T024</accession>
    <name>A0A8C2T024_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Interphotoreceptor matrix proteoglycan 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Sialoprotein associated with cones and rods</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">IMPG1</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Chondroitin sulfate-, heparin- and hyaluronan-binding protein. May serve to form a basic macromolecular scaffold comprising the insoluble interphotoreceptor matrix.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Cilium</location>
            <location evidence="2">Photoreceptor outer segment</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Photoreceptor inner segment</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
            <location evidence="3">Extracellular space</location>
            <location evidence="3">Extracellular matrix</location>
            <location evidence="3">Interphotoreceptor matrix</location>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
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            <taxon>Vertebrata</taxon>
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            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
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            <taxon>Neognathae</taxon>
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            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
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        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
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                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
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        <scope>IDENTIFICATION</scope>
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    </evidence>
    <sequence length="1013" mass="108332" checksum="BB083264A223DE83" modified="2022-01-19" version="1">MAQPAHLNQNLPDLGGPFLYRDQDDGEKSSYSVETPYGFLLDLDFLKYVDDIESGQTLRKVPLPRRAKGTRPQPGSLRSPSSHPSGWTSTESLASTISEDGRSAMLLSPYGRVVPEAPGKQTSLPTSPPPAVRLLPPPARKCLARNPQVEKTLLETSKRLEQEQSRSQPGAPSQVHPWGPAGSEGQPGSVRMSPGSSGRSTPAAGLGTAPLQHVREQMAAALRQLRELEEQVKTIPLLEMQICELQREKAKLMEKLSVEPSKVLSDHPDGSEEHQTELEGEVEPAKGRASKIAELRKLTEKLAVPERGKAMAGRPRAAERQCRSVAVGEERSMSDAVFYYRSQRDGSDVLDGKERRDVAVWVLESSLGLAPEAERELELLQQTVGHQKDVIALMEGHLQEATRELEELRMEVCARQPRSCVDKEVTARPQVAEVLVEAAVATQSRAAGDSVEMADVAVGCAPQTACIGVSCRPHGQDVAVGPDAAVGREDKGSQADVGPADMDPISTAPLYTGPADSSPDDTGPPRAGPVDTGTADPHRTSTDPTDPGPAVPLCEQVEPRVCDAGCQQPPLGSPSAPTAQRAAGLEAMGAATHPTALSAEVEDVSQVPAQDGRAAPSPAARALKSIMKKRDGPPRSEAEGSKKSLQFVGVLNGEYESTSSEEEEEEEGDSSSEKASADSSDSEELGGTNDTSEEEEEEEAVGGDGQNELSGQQEGEGTSTAPPEPPEVKEKFELSPRMREACLIVKTHLGHPTATKSKEALASSSLVLQEWFRLSSQKSSVPDTVANHLLAFAELSPALLTHVVNLADGNGNTALHYSVSHSNFHIVKLLLDTGVCNVDHQNKAGYTALMLAALAAVEQEDDMNVVRRLFSMGNVNAKASQAGQTALMLAVSHGRQEMVEALLGCGADVNLQDEEGSTALMCACEHGRVETVKLLLAQPTCDVSIVDSVRHRCRGLSTPTHPQAQTQTQTPPNFSPVLLRMVTTPSPSRWRQDTATLQCCCTPTSMGQRRSHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T0V7</accession>
    <name>A0A8C2T0V7_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">INO80 complex subunit E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">INO80E</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015706279.1">
        <property type="nucleotide sequence ID" value="XM_015850793.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015706280.1">
        <property type="nucleotide sequence ID" value="XM_015850794.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T0V7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005009880.1">
        <property type="protein sequence ID" value="ENSCJPP00005006252.1"/>
        <property type="gene ID" value="ENSCJPG00005005876.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107307296"/>
    <dbReference type="CTD" id="283899"/>
    <dbReference type="GeneTree" id="ENSGT00390000011918"/>
    <dbReference type="OrthoDB" id="5977486at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026678">
        <property type="entry name" value="INO80E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056515">
        <property type="entry name" value="INO80E_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21812">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21812:SF1">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24237">
        <property type="entry name" value="INO80E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INO80 complex subunit E N-terminal" evidence="2">
        <location>
            <begin position="37"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="191"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="253" mass="27070" checksum="D92EFBF35BAE273F" modified="2022-01-19" version="1">MGSGLFHKPEAEVARSVRHFRKMNGAVDQDGGGGSGCRRRYRALKRRLRLLLYEQECFQEELRRAQRRLLRVSRDKSFLLDRLLQYEQVDDDSSDSDATASSDSDGEAPKGAEPPPLKRKRSPTGGGASPPSNPGLAPPTSYLSTLGSPPYSPFPSDYLAPPERPRGPTRRNKGARRIQLPSAPPPPPPSLSFVPPAVLGSGSGSVSAPPPPPKAPGPVPQTVPRRLLSDGGDGSGDDGMDGDDELVIDIPEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T1T9</accession>
    <name>A0A8C2T1T9_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Myosin light chain kinase 2, skeletal/cardiac muscle</fullName>
            <ecNumber evidence="4">2.7.11.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">MYLK2</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Implicated in the level of global muscle contraction and cardiac function. Phosphorylates a specific serine in the N-terminus of a myosin light chain.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">May interact with centrin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.18" evidence="4"/>
    <dbReference type="RefSeq" id="XP_015737599.1">
        <property type="nucleotide sequence ID" value="XM_015882113.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T1T9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005009810.1">
        <property type="protein sequence ID" value="ENSCJPP00005006195.1"/>
        <property type="gene ID" value="ENSCJPG00005005814.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107323244"/>
    <dbReference type="KEGG" id="cjo:107323244"/>
    <dbReference type="CTD" id="85366"/>
    <dbReference type="GeneTree" id="ENSGT00940000161489"/>
    <dbReference type="OrthoDB" id="10260894at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004687">
        <property type="term" value="F:myosin light chain kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055008">
        <property type="term" value="P:cardiac muscle tissue morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007274">
        <property type="term" value="P:neuromuscular synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032971">
        <property type="term" value="P:regulation of muscle filament sliding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014816">
        <property type="term" value="P:skeletal muscle satellite cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006941">
        <property type="term" value="P:striated muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd14190">
        <property type="entry name" value="STKc_MLCK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000359">
        <property type="entry name" value="myosin light chain kinase 2, skeletal/cardiac muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000135">
        <property type="entry name" value="Putative myosin light chain kinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042717">
        <property type="entry name" value="MLCK2_STKc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="517"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="9"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="201"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="256"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="271"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="319"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="341"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="368"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="448"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="550"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="828" mass="88105" checksum="B1D7816A94E02544" modified="2022-01-19" version="1">MEQHEVPGNTANMGGSGSVAPSGTETSTAQPDPTAATNAVQTQNGGKEEPKEKAVGAAGEPHGGTAEPVKEKVPSAAEKEEPGKEVALGAAVEAQGAAREKAESKGGKVDPEQEKDPNAAQHWDGGEKEAAKEGASAAETNRGKEEPAKDKTTMGGSQGEMVEPAQGKSSDVAGAQKEPPKENAPSAPGTEAEGEAEPTKKASAATEAEGGKAEPAGTAPAAAPAHAKGEPAKEQPAAVKAEDGGKNVVKAKKSPAAKQPAKKTPAAAAKEGGKKPTKVEKNTAVTKVQDGKETVKEKATAPAKEKATDTVQKPPAAVKAEDGGQERMEKGPAAAGAQGEGVKEANAEQTNKEQPLRGPEPTRPALMQSLSCPATCQRQEQPGLEMAAMETIPEETPMALAGEGLAEPTPAQRDLQPPEQPVPEGSAATPQERTLPGAEEQPQLGSEPPGHAEQPGPGAAGQPAVTVAVPPPSPYLTPDFGKEDPFEILDDVPPPPAPFAHRIVSLRTGSVSSQYNLSSKEILGGGKFGEVHTCTEKQTGLKLAAKVIRKQGAKDKEMVLLEIDVMNQLNHRNLIQLYDAIETPREIILFMEFVEGGELFERIIDDDYHLTEVDCMVFVRQICEGIRFMHHMHVLHLDLKPENILCVAATGHMVKIIDFGLARRYNPEEKLKVNFGTPEFLSPEVVNYEQVSYSTDMWSMGVITYMLLSGLSPFLGDNDTETLNNVLAANWYFDEETFESVSDEAKDFVSNLIIKEKSARMSAGQCLQHPWLTNLAEKAKRCNRRLKSQVLLKKYVMRRRWKKNFIGVCAANRFKKITSSGSLTALGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T2M9</accession>
    <name>A0A8C2T2M9_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Serine/threonine-protein kinase CHK1</fullName>
            <ecNumber evidence="5">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">CHK1 checkpoint homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Checkpoint kinase-1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Serine/threonine-protein kinase Chk1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="primary">CHEK1</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="28" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="28" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Microtubule organizing center</location>
            <location evidence="3">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2T2M9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005009593.1">
        <property type="protein sequence ID" value="ENSCJPP00005006042.1"/>
        <property type="gene ID" value="ENSCJPG00005005689.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159682"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035402">
        <property type="term" value="F:histone H3T11 kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902742">
        <property type="term" value="P:apoptotic process involved in development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071260">
        <property type="term" value="P:cellular response to mechanical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007077">
        <property type="term" value="P:mitotic nuclear membrane disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045814">
        <property type="term" value="P:negative regulation of gene expression, epigenetic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045839">
        <property type="term" value="P:negative regulation of mitotic nuclear division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042127">
        <property type="term" value="P:regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010569">
        <property type="term" value="P:regulation of double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046602">
        <property type="term" value="P:regulation of mitotic centrosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd14069">
        <property type="entry name" value="STKc_Chk1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000301">
        <property type="entry name" value="Serine/threonine-protein kinase Chk1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000229">
        <property type="entry name" value="Serine/threonine-protein kinase Chk1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.80:FF:000007">
        <property type="entry name" value="Serine/threonine-protein kinase Chk1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034670">
        <property type="entry name" value="Chk1_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF107">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 24 25" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="18" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="16" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0418">Kinase</keyword>
    <keyword evidence="12 24 25" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 25" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="27">
        <location>
            <begin position="9"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="273"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00030691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00032547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00070697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="476" mass="53868" checksum="1A1316584D0C1CE8" modified="2022-01-19" version="1">MAVPFVEDWDLVQTLGEGAYGEVQLALNRRTEEAVAVKIVDMKRAADCPENIKKEICINKMLNHDNVVKFYGHRREGATQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFQQLIAGVVYLHSMGITHRDLKPENLLLDDRDNLKISDFGLATVFKHNGRERLLNKMCGTLPYVAPELLRRPEFRAEPVDVWACGVVLTAMLAGELPWDQPSDSCQEYSDWKERKTYLSPWRKIDSAPLALLHKILTESPTARITIPDIKKDRWYCRPLKKGTKRSRVSSGGVTESPGALPKHIRSDTDFSPVKSALGEDKVSYSTSQPEPGTGGTLWDGSTGSIDRLVQGISFSQPACPEHMLLNSQLLGTPGSSQSPWQRLVRRMTRFFTKLDADGSYRSLRDVCEKMGYGWKQSCTNQVTISTTDRRNNKLIFKVNLLEMESRILVDFRLSKGDGLEFKRHFLKIKGKLSDVVSTQKVWLPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T2S0</accession>
    <name>A0A8C2T2S0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="13">PPIase</shortName>
            <ecNumber evidence="13">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">PPIL4</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2 13">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the cyclophilin-type PPIase family. PPIL4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="13"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2T2S0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005010455.1">
        <property type="protein sequence ID" value="ENSCJPP00005006664.1"/>
        <property type="gene ID" value="ENSCJPG00005006198.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156283"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01921">
        <property type="entry name" value="cyclophilin_RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12235">
        <property type="entry name" value="RRM_PPIL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000016">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000267">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035542">
        <property type="entry name" value="CRIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035538">
        <property type="entry name" value="Cyclophilin_PPIL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45843">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45843:SF1">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12 13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9 13" id="KW-0697">Rotamase</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="15">
        <location>
            <begin position="85"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="319"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="26"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="447"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="256"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="460"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="478"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="513"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="557" mass="64118" checksum="32E9A3691BC1CA6A" modified="2022-01-19" version="1">MHLWPQGDKCSLSAVQGVSKAAIKARSVPSAAVPPRGPARRLPQSPCTAHGARPPPRRQGAPPQRVGPDRIGPAEREAAMAVLLETTLGDMVIDLYTEERPRACLNFLKLCKIKYYNYCLIYNVQRDFIIQTGDPMGTGRGGESIFCKLYGDQARFFEAEKVPRIKHKKKGTVSMVNNGSDLHGSQFLITTGENLDYLDGVHTVFGEVTEGMDVLKTINETFVDKDFIPYQDIRINHTVILDDPFDDPPDLPIPDRSPEPTKEQLDSGRIGADEEIDDMKGRSADEIEEVQAEKEAKTRAILLEMVGDLPDAEVKPPENVLFVCKLNPVTTDEDLEIIFSRFGPIKSCEVIRDWKTGESLCYAFIEFEKEEDCEKAYFKMDNVLIDDRRIHVDFSQSVAKIKWKGKGGQYTKDDFKEYEKGRDKTSKFALKEKVKPKQDAKYDLVLDEEEEESQSSQSHLAKKQKKKKHYHSEDEEDDKRTKKYKDSDRKHEGERCREKTKSEKKDRHRSRSRSQERSYSKHKDKYREDVRVRDWDKKRDRSRSPKKSKDKERSKYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T4Z3</accession>
    <name>A0A8C2T4Z3_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC107324657</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 12">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T4Z3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005011637.1">
        <property type="protein sequence ID" value="ENSCJPP00005007528.1"/>
        <property type="gene ID" value="ENSCJPG00005006918.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183165"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000005">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000002">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 12" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="13">
        <location>
            <begin position="57"/>
            <end position="254"/>
        </location>
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        <location>
            <begin position="256"/>
            <end position="401"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
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        <source>
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        <source>
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            <dbReference type="SMART" id="SM00865"/>
        </source>
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            <dbReference type="Ensembl" id="ENSCJPP00005007528.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
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    </evidence>
    <sequence length="457" mass="50910" checksum="DC058DC65A05D3D3" modified="2022-01-19" version="1">MFKQLCNMGRECISVHVGQAGVQMGNACWELYCLEHGIQPDGTMPSDKTIGGGDDSFNTFFSETGAGKHVPRAVFVDLEPAVIDEVRNGTYRQLFHPEQLITGKEDAANNYARGHYTVGKEIIDLVLERIRKLSDQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFAIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLIGQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLVMYSPIISAEKAYHEQLSVSEITNACFEPSNQMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIAAIKTKRTIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGTDSMDGEDEGEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T595</accession>
    <name>A0A8C2T595_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transmembrane protein 116</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TMEM116</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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    <dbReference type="AlphaFoldDB" id="A0A8C2T595"/>
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        <property type="gene ID" value="ENSCJPG00005007032.1"/>
    </dbReference>
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        <property type="component" value="Chromosome 15"/>
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        <property type="term" value="C:plasma membrane"/>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
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        <property type="entry name" value="GCR1-cAMP_receptor"/>
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    </dbReference>
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        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GCR1CAMPR"/>
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    </dbReference>
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    </dbReference>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005007707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="349" mass="38879" checksum="D7D713275A4D056D" modified="2022-01-19" version="1">MLYPGYAPIPSQPVLCSVSVTGSSSIITYAIFQNVVRSPEVRPLFYLSLSDLFLGMCWIAGALLYSTPTSKQDLICYNLQAMGQVFYVASFLYTANYTWHLYMDLKMKYNQNLNRMPPTVSTIDCGNCAVVLSSPSLIPFLLMMPVFCLGNSSNCYQNFSQKHGCLLMHTEMAEPTNEPLTLNGSVCRAMHFYGIGVFLVSFLVSFIAILVVLIQARGLYKRFVNSTGFLGDQQWAMIKMVEQRVVFYPIAFFCCWAPAVLLGILKLTASTSSKIYMALLVLQALTAASQGLLNCIVYGWTQHVFLSLKRNICRDVDTQTPLLRSQKKFYASTLPASPPDTEVSTSTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T5R6</accession>
    <name>A0A8C2T5R6_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Empty spiracles homeobox 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">EMX1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Chordata</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMX homeobox family.</text>
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        <property type="protein sequence ID" value="ENSCJPP00005008907.1"/>
        <property type="gene ID" value="ENSCJPG00005007896.1"/>
    </dbReference>
    <dbReference type="KEGG" id="cjo:107314117"/>
    <dbReference type="GeneTree" id="ENSGT00940000161476"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
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        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="C:nucleolus"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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    </dbReference>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:response to xenobiotic stimulus"/>
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        <property type="project" value="Ensembl"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Empty spiracles homeobox 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Homeodomain-like"/>
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    <dbReference type="InterPro" id="IPR050877">
        <property type="entry name" value="EMX-VAX-Noto_Homeobox_TFs"/>
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        <property type="entry name" value="HD"/>
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        <property type="entry name" value="HD_metazoa"/>
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        <property type="entry name" value="HTH_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24339">
        <property type="entry name" value="HOMEOBOX PROTEIN EMX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24339:SF26">
        <property type="entry name" value="HOMEOBOX PROTEIN EMX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
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        <property type="entry name" value="HTHREPRESSR"/>
    </dbReference>
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        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="136"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="7">
        <location>
            <begin position="138"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="195"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="196"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="222"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005008907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="236" mass="26484" checksum="AF24EE12DC578D58" modified="2022-01-19" version="1">MFQPSAKRCFTIESLVAKDTPLSPEEPLRPSALNYPPPAASDAFPGGFQGAAAAGRALYGGTELVFPEAVGHPALPVAPHQLGASPLPHPHSFFGPQHRDPLNFYPWVLRNRFFGHRFQGNEVSQESLLLHGPFARKPKRIRTAFSPSQLLRLERAFEKNHYVVGAERKQLASSLSLSETQVKVWFQNRRTKYKRQKLEEEGPDSEQKKKGSHHINRWRLATKQSSGEDIDVTSND</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T5T1</accession>
    <name>A0A8C2T5T1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Sarcosine dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="14">1.5.8.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">SARDH</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the last step of the oxidative degradation of choline to glycine. Converts sarcosine into glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + sarcosine + oxidized [electron-transfer flavoprotein] + H(+) = (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + reduced [electron-transfer flavoprotein] + glycine</text>
            <dbReference type="Rhea" id="RHEA:19793"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="Rhea" id="RHEA-COMP:13257"/>
            <dbReference type="Rhea" id="RHEA-COMP:14738"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57433"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:136572"/>
            <dbReference type="ChEBI" id="CHEBI:141005"/>
            <dbReference type="EC" id="1.5.8.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:19794"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13">Amine and polyamine degradation; sarcosine degradation; formaldehyde and glycine from sarcosine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GcvT family.</text>
    </comment>
    <dbReference type="EC" id="1.5.8.3" evidence="14"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2T5T1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005012108.1">
        <property type="protein sequence ID" value="ENSCJPP00005007901.1"/>
        <property type="gene ID" value="ENSCJPG00005007048.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157589"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008480">
        <property type="term" value="F:sarcosine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.120:FF:000023">
        <property type="entry name" value="Sarcosine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.9.10:FF:000046">
        <property type="entry name" value="Sarcosine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000769">
        <property type="entry name" value="Sarcosine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.110:FF:000006">
        <property type="entry name" value="Sarcosine dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1400:FF:000004">
        <property type="entry name" value="Sarcosine dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.110">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1400">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032503">
        <property type="entry name" value="FAO_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GcvT/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GcvT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCVT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757:SF11">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16350">
        <property type="entry name" value="FAO_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="17">
        <location>
            <begin position="82"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase central" evidence="20">
        <location>
            <begin position="443"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="GCVT N-terminal" evidence="18">
        <location>
            <begin position="501"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="domain" description="Aminomethyltransferase C-terminal" evidence="19">
        <location>
            <begin position="836"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="37"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00052249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00059128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00060644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00066703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00074437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF16350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005007901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="931" mass="103154" checksum="23F4286E37EEEA01" modified="2022-01-19" version="1">WALPLLPSSRIAFQSAVDMSYMSCALRVAAPRRLPAPWRSPRPYSSTTGPTAEKSVPYQKTLKEESNGSTGPSRPPPASAEVVVVGGGSLGCQTTYHLAKMGITNVVLLERDRLTAGTTWHTAGLLWQLRPSDVEVELLAHTRDVVSRDLPAETGLHTGWVQNGGLFIASNKQRLDEYKRLMSLGKVYGVESHVLTPAQTKELYPLMNVDDLYGTLYVPKDGTMDPAGTCSTLTRAAAARGATIIENCPVTGIQVRTDDFGVKRVHAVETAHGTIQTPCVVNCAGVWARALGRLAGVHVPLVAMHHAYVVTERIEGIQNMPNVRDHDASVYLRLQGDALSVGGYESNPIFWEEVSEKFAFSLFDLDWDVFMQHIQGAINRVPVLERTGIKSTVCGPESFTADHKPLMGEAPEVRGFFLGCGFNSAGMMLGGGCGKELAHWIIHGRPEKDMYGYDIRRFHHSLTDNNRWIRERSHESYAKNYSVVFPHDEPLAGRNMRKDPLHQELLQQGCVFQERHGWERPGWFSPGGAAPVLNYDYYGAYSQERHRDYTYNQLLADEYTFDFPPHHHIIKKECLTCRNALALFNMSYFGKFYLVGPEATKAANWLFSADVSKAPGSTVYTCMLNKRGGVESDLTVSRISPGDPSSPLAPSFQGDGYYLAIGGAVAQHNWSHITTVLQDMKLQCKLIDCSEELGMMSLQGPLSRGVLQELLDTDLSNEAFPFSTHKLVKAAGCTVRAMRLSFVGEMGWELHVPREDCVKVYKAVMEAGARHGIINAGYRAIDSLSIEKGYRHWHADLRPDDTPLEAGLAFTCKLKSSIPFLGREAVEAQKATGIFRRLVCFTIDEKVPMFGLEAIWRDGKVVGHIRRADFGFAIDKTIAYGYIRDPAGGPVSLDFVKSGSYELERMGVRYPAQAHTKSPFDPDNKRVKGIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T6A7</accession>
    <name>A0A8C2T6A7_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Late endosomal/lysosomal adaptor, MAPK and MTOR activator 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LAMTOR3</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LAMTOR3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015717577.1">
        <property type="nucleotide sequence ID" value="XM_015862091.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T6A7"/>
    <dbReference type="SMR" id="A0A8C2T6A7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005011748.1">
        <property type="protein sequence ID" value="ENSCJPP00005007614.1"/>
        <property type="gene ID" value="ENSCJPG00005006974.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107313650"/>
    <dbReference type="KEGG" id="cjo:107313650"/>
    <dbReference type="CTD" id="8649"/>
    <dbReference type="GeneTree" id="ENSGT00390000013159"/>
    <dbReference type="OrthoDB" id="343907at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990877">
        <property type="term" value="C:FNIP-folliculin RagC/D GAP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071986">
        <property type="term" value="C:Ragulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019209">
        <property type="term" value="F:kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071230">
        <property type="term" value="P:cellular response to amino acid stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902414">
        <property type="term" value="P:protein localization to cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.30:FF:000003">
        <property type="entry name" value="ragulator complex protein LAMTOR3 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015019">
        <property type="entry name" value="LAMTOR3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13378:SF1">
        <property type="entry name" value="RAGULATOR COMPLEX PROTEIN LAMTOR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13378">
        <property type="entry name" value="REGULATOR COMPLEX PROTEIN LAMTOR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08923">
        <property type="entry name" value="MAPKK1_Int"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01278">
        <property type="entry name" value="MAPKK1_Int"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103196">
        <property type="entry name" value="Roadblock/LC7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005007614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="124" mass="13680" checksum="0A5196D390053C13" modified="2022-01-19" version="1">MADDLKRFLYKKLPSVEGLHAIVVSDRDGVPVIKVANDNAPEHALRPGFLSTFALATDQGSKLGLSKNKSIICYYNTYQVVQFNRLPLVVSFIASSNANTGLIVSLEKELTPLFEELRQVVEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T6A9</accession>
    <name>A0A8C2T6A9_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T6A9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005010791.1">
        <property type="protein sequence ID" value="ENSCJPP00005006925.1"/>
        <property type="gene ID" value="ENSCJPG00005006412.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01120000276204"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="299" mass="33405" checksum="0997C6B78ED9E954" modified="2022-01-19" version="1">MCPYVSLWGSYVSLCVSMGQLWVSESLWGSYGSHRAGPQHRDNNMGPQHRDNNGGPQHRDSMGTQHRDPNMGPQHRDSMGTQHRDPNMGTQHQRDPNVGTQQRDPNGGPQHRDPSMGTQKRDPNMGTQHQRDPNGGPQKRDPNMGTQHRDPNMGTQHQRDPNVGTQQRDPNMGTQHRDPKMGTQHQRDPNMGTQQRDPNVGPQHRDPNMGPDNHGDPNMGHNNQGDPNMGHNNQGDPNLGPANLRSPHNPLREEMLRAPPPGLLVVMGQPHRRTSLMGPPPPSIPYGSFPTDLWVRLWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T875</accession>
    <name>A0A8C2T875_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptide chain release factor 1-like, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Mitochondrial translational release factor 1-like</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">MTRF1L</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Mitochondrial peptide chain release factor that directs the termination of translation in response to the peptide chain termination codons UAA and UAG.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015713712.1">
        <property type="nucleotide sequence ID" value="XM_015858226.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T875"/>
    <dbReference type="Ensembl" id="ENSCJPT00005013122.1">
        <property type="protein sequence ID" value="ENSCJPP00005008686.1"/>
        <property type="gene ID" value="ENSCJPG00005007734.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107311592"/>
    <dbReference type="KEGG" id="cjo:107311592"/>
    <dbReference type="CTD" id="54516"/>
    <dbReference type="GeneTree" id="ENSGT00940000155683"/>
    <dbReference type="OrthoDB" id="2019491at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070126">
        <property type="term" value="P:mitochondrial translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000004">
        <property type="entry name" value="Peptide chain release factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1660:FF:000004">
        <property type="entry name" value="Peptide chain release factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1660:FF:000011">
        <property type="entry name" value="Peptide chain release factor 1-like, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050057">
        <property type="entry name" value="Prokaryotic/Mito_RF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804:SF3">
        <property type="entry name" value="PEPTIDE CHAIN RELEASE FACTOR 1-LIKE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="12">
        <location>
            <begin position="258"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="76"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00055528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00070847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00082737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005008686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="394" mass="44955" checksum="B29417FF2C5CBAE2" modified="2022-01-19" version="1">MGLLARALRAARGCRAIALPARSYHAGSGRVSALAVRPQQPRRGLSAWPRLDELFATPSLSRLLEARVQGEAGPELAELIQRLRDKERELRDTRELALQDESEDLRKLAEREIVSCEEEIAELKQQIVLLLIPSEETHNSDLVMEVTAGVGGQEAMLFTSEIFDMYRRYAAYKKWKFEILEYFPSEIGGLRHAVASIAGLDAYKYMKFEGGVHRVQRVPKTEKQGRIHTSTMTVAILPQPTEMELKINPKDLRIETKRASGAGGQHVNTTDSAVRIVHIPTGVTSECQQERSQIRNKEKAMQMLCAKLYNIKLEEETKKRNSVRKIQIGTKGRSEKIRTYNFLQDRITDHRISRSVHHTESFMLGEEMLDEMIQALKEYADYESLMEIISEYEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T9Y6</accession>
    <name>A0A8C2T9Y6_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-binding protein RFX6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Regulatory factor X 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">RFX6</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015714286.1">
        <property type="nucleotide sequence ID" value="XM_015858800.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T9Y6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005015654.1">
        <property type="protein sequence ID" value="ENSCJPP00005010603.1"/>
        <property type="gene ID" value="ENSCJPG00005009203.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107311900"/>
    <dbReference type="KEGG" id="cjo:107311900"/>
    <dbReference type="CTD" id="222546"/>
    <dbReference type="GeneTree" id="ENSGT01050000244879"/>
    <dbReference type="OrthoDB" id="10056949at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042593">
        <property type="term" value="P:glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003310">
        <property type="term" value="P:pancreatic A cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003311">
        <property type="term" value="P:pancreatic D cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090104">
        <property type="term" value="P:pancreatic epsilon cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035774">
        <property type="term" value="P:positive regulation of insulin secretion involved in cellular response to glucose stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003309">
        <property type="term" value="P:type B pancreatic cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000211">
        <property type="entry name" value="Regulatory factor X, 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003150">
        <property type="entry name" value="DNA-bd_RFX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039779">
        <property type="entry name" value="RFX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057321">
        <property type="entry name" value="RFX1-4/6/8-like_BCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619:SF28">
        <property type="entry name" value="DNA-BINDING PROTEIN RFX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619">
        <property type="entry name" value="RFX TRANSCRIPTION FACTOR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25340">
        <property type="entry name" value="BCD_RFX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02257">
        <property type="entry name" value="RFX_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51526">
        <property type="entry name" value="RFX_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0221">Differentiation</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RFX-type winged-helix" evidence="11">
        <location>
            <begin position="111"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="63"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="866"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="871"/>
            <end position="884"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00072476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00077088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005010603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="914" mass="101125" checksum="1BC2D9013059EAA9" modified="2022-01-19" version="1">MAKGPEQEDAFLHLPATQAMSATAGPEECYVELLAGGLLPYAEEGLGAGRGLTELPAAVKSEVPFNGETLSSEEEDANTRDGKLRAADKSPSPKKSITQMMKDKKKQTQLTLQWLEENYIVCEGVCLPRCILYAHYLDFCRKEKLEPACAATFGKTIRQKFPLLTTRRLGTRGHSKYHYYGIGIKESSAYYHSVYSGKGLTRFSGSKLKNEGGFTRKYSLSSKTGTLLPEFPSAQHLLLQGCISKDKVDTLIMMYKTHCQCVLDNAINGNFEEIQHFLLHFWQGMPDHLLPLLENPIIVDIFCVCDSILYKVLTDVLIPATMQEMPESLLADIRNFAKNWEQWVVSSLENLPEILMDKKLPIARRFVSSLKRQTSFLHLAQIARPALFDQHVVNSMVSDIEKVDLNSIGSQALLAVSGSTDSDGEVYSEYDSITVFQELKDLLKKNATVESFIEWLDTVVEQRVIKASKQNGRSLKKRAQDFLLKWSFFGARVMHNLTLNNASSFGSFHLIRMLLDEYILLAMETQFNNDKEQELQNLLDKYMKNLDASKATFTASPSSCFLANRNKAASLPSDASVKNECLAEQTYVSLSASQPSSVTSGLNPFATGDGENMQLTGQMELPQSTGHLMTPPISPALVSRGSVINQGPMAVRPPSVGPVLSTHSQCSSYSEPLYQTLSQTNQNYYGNNSSYQAMFRTQAHSTSGVYQHRAEHSRFNALSEQQFSRDYFNSSCAVTPYSARSPSSYCPSSMTQDAHNMQFLNTGSFNFLSNSASTCPGATYPPNASNGYYGNNISYPESHRLGSMVDQHVSVISSVSSIRPLPSYNDTHDPLNILDDSGRKQTGSYYTESSPSIVCRTAMSSNMQTTSSSQCMYGTPSQFTPQENLESHEPPNRDMVSSLPPINTVFMGAAAGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TCK6</accession>
    <name>A0A8C2TCK6_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="19">NPC intracellular cholesterol transporter 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">NPC1</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>cholesterol(in) = cholesterol(out)</text>
            <dbReference type="Rhea" id="RHEA:39747"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the patched family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015710907.1">
        <property type="nucleotide sequence ID" value="XM_015855421.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005015785.1">
        <property type="protein sequence ID" value="ENSCJPP00005010698.1"/>
        <property type="gene ID" value="ENSCJPG00005009280.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107310089"/>
    <dbReference type="KEGG" id="cjo:107310089"/>
    <dbReference type="CTD" id="4864"/>
    <dbReference type="GeneTree" id="ENSGT00940000156182"/>
    <dbReference type="OrthoDB" id="6510177at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015485">
        <property type="term" value="F:cholesterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120020">
        <property type="term" value="F:cholesterol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007628">
        <property type="term" value="P:adult walking behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071404">
        <property type="term" value="P:cellular response to low-density lipoprotein particle stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071383">
        <property type="term" value="P:cellular response to steroid hormone stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033344">
        <property type="term" value="P:cholesterol efflux"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042632">
        <property type="term" value="P:cholesterol homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010878">
        <property type="term" value="P:cholesterol storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000900">
        <property type="term" value="P:cyclodextrin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090150">
        <property type="term" value="P:establishment of protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030299">
        <property type="term" value="P:intestinal cholesterol absorption"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032367">
        <property type="term" value="P:intracellular cholesterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001889">
        <property type="term" value="P:liver development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031579">
        <property type="term" value="P:membrane raft organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016242">
        <property type="term" value="P:negative regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022008">
        <property type="term" value="P:neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012501">
        <property type="term" value="P:programmed cell death"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009410">
        <property type="term" value="P:response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046718">
        <property type="term" value="P:symbiont entry into host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1640.10:FF:000008">
        <property type="entry name" value="NPC intracellular cholesterol transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1640.10:FF:000010">
        <property type="entry name" value="NPC intracellular cholesterol transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004765">
        <property type="entry name" value="NPC1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053956">
        <property type="entry name" value="NPC1_MLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032190">
        <property type="entry name" value="NPC1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00917">
        <property type="entry name" value="2A060601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45727">
        <property type="entry name" value="NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45727:SF2">
        <property type="entry name" value="NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22314">
        <property type="entry name" value="NPC1_MLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16414">
        <property type="entry name" value="NPC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0732">Signal</keyword>
    <keyword evidence="14" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="12" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034544565" evidence="17">
        <location>
            <begin position="31"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="268"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="362"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="630"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="663"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="693"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="736"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="769"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1106"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1132"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1206"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1236"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="18">
        <location>
            <begin position="629"/>
            <end position="794"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005010698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1286" mass="143421" checksum="FF61A17E236FF956" modified="2022-01-19" version="1">MGGPQGSPGPGTRRLLLFLLLLLSVAQVLPQQCIWYGECGVASGDKRYNCAYNGPPIDLPEDGYDLMQELCPGLFFGNVSTCCDILQLQTLKNNLQLPLQFLSRCPSCFYNLINLFCELTCSPNQSDFLNVTSTIPYYDPVSKENRSSITELQYFIGERFANEMYNACKDVEAPSSNVKALGLLCGKDAKDCNATNWIEYMFNKDNGQTPFSIIPIFSDVPVHGMNPMNNATKGCNESVDDSTGPCSCQDCSIVCGPKPQPPPLPVPWLLFGLDAVYIIMWISYMGFLLIFFALVFGVWCYRRRHFVSEYTPIDSNVAFSVNSHRDNGKITCGERLGERFENGLKMTFTSWGAFCVRNPRPVILFSVVFIAMCCSGFVYIKATTNPVDLWSAPSSQARKEKEYFDKHFGPFFRTEQLIIQAPNSHPDIYSPYPSGADVPFGPPLNKDILHQVLDLQDAIVNLAASFDNETVMLKDICLAPLAPYNNNCTIFSVLNYFQNSHSVLDHTVGDEFFVYADYHTHFLYCVRAPASLNDTSLLHDPCLGAFGGPVFPWLVLGGYDGDNYNNATALIITFPVSNYYNDSKKMMKALAWEKEFINFLKNYDNPNLTISFSAERSIEDEINRESRSDVSTVVISYVVMFVYISIALGHIQSWGRLLVDSKISLGIAGILIVLSSVACSIGIFSYFGVPVTLIVVEVIPFLVLAIGVDNIFIIVQTLQRDERLEGETLDKQIGRVLGDVAPSMFLSSFSETVAFFLGTLSTMPAVRTFSLFAGMAVLIDFILQVTCFVSLLGLDIRRQERNRLDILCCIKGSEEMRGVQRSESILFLFFKNFYSPYLLKDWMRPIVIALFVGVLSFSTAVIHNVEIGLDQSLSMPDDSYVVNYFQQFSKYMHTGPPVYFVLEEGHNYTSLEGQNMVCGGTGCNNDSLVQQVFNAAEISSYTRIGYAPSSWIDDYFDWVKPQSSCCRVYNTTGQFCNASVTDPSCTRCRPLTQEGKQRPQGEDFMTFLPMFLSDNPNPKCGKGGHAAYGSAVDLINNGTDVGATYFMTYHTVLKKSSDYIDSMKKARDIAANITETMGIKEKNYRVFAYSVFYVFYEQYLTIVNDAIFNLCVSLGSIFLVTALLLGFEVWAAVVVTVTIAMIIVNMFGVMWLWGISLNAVSLVNLVMSCGIAVEFCSHVTRAFTVSTKGSRVERAEEALSHMGSSVFSGITLTKFGGIVVLAFSKSQIFKIFYFRMYLAMVLLGATHGLVFLPVLLSYIGPSVNKAKTHAAQERSRGTERERLLYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TEF4</accession>
    <name>A0A8C2TEF4_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein FMC1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FMC1</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Plays a role in the assembly/stability of the mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMC1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015717320.1">
        <property type="nucleotide sequence ID" value="XM_015861834.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TEF4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005015279.1">
        <property type="protein sequence ID" value="ENSCJPP00005010287.1"/>
        <property type="gene ID" value="ENSCJPG00005008991.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107313511"/>
    <dbReference type="KEGG" id="cjo:107313511"/>
    <dbReference type="CTD" id="154791"/>
    <dbReference type="GeneTree" id="ENSGT00390000012258"/>
    <dbReference type="OrthoDB" id="551431at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008637">
        <property type="term" value="P:apoptotic mitochondrial changes"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071542">
        <property type="term" value="P:dopaminergic neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061744">
        <property type="term" value="P:motor behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050995">
        <property type="term" value="P:negative regulation of lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061469">
        <property type="term" value="P:regulation of type B pancreatic cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd20271">
        <property type="entry name" value="Complex1_LYR_FMC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037667">
        <property type="entry name" value="FMC1_homologue"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31716">
        <property type="entry name" value="PROTEIN FMC1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31716:SF1">
        <property type="entry name" value="PROTEIN FMC1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13233">
        <property type="entry name" value="Complex1_LYR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00045742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005010287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="107" mass="12253" checksum="20ED84969871EA3E" modified="2022-01-19" version="1">MAALGSPLRTLRELLRELRHISGRAYRDTAAYRHVLNAFRAHRVTSEKLCRAQQELHFQAATYLCLLRSVRQHQALHREYHGRGERSPEEVAGLVGFRLPRQPGGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TGD7</accession>
    <name>A0A8C2TGD7_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">O-linked N-acetylglucosamine (GlcNAc) transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">OGT</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TGD7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005019106.1">
        <property type="protein sequence ID" value="ENSCJPP00005013273.1"/>
        <property type="gene ID" value="ENSCJPG00005011185.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155085"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044545">
        <property type="term" value="C:NSL complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017122">
        <property type="term" value="C:protein N-acetylglucosaminyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005547">
        <property type="term" value="F:phosphatidylinositol-3,4,5-trisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097363">
        <property type="term" value="F:protein O-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071333">
        <property type="term" value="P:cellular response to glucose stimulus"/>
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    <dbReference type="GO" id="GO:0032922">
        <property type="term" value="P:circadian regulation of gene expression"/>
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    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:hemopoiesis"/>
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        <property type="term" value="P:membraneless organelle assembly"/>
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        <property type="term" value="P:TORC1 signaling"/>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="OGT"/>
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        <property type="entry name" value="TPR-like_helical_dom_sf"/>
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    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
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    <dbReference type="PANTHER" id="PTHR44366">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE 110 KDA SUBUNIT"/>
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        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE 110 KDA SUBUNIT"/>
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        <property type="entry name" value="TPR_1"/>
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        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="3"/>
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        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
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    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="12"/>
    </dbReference>
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        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
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    <dbReference type="PROSITE" id="PS50005">
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        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
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        <location>
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    <evidence type="ECO:0000256" key="1">
        <source>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TGU3</accession>
    <name>A0A8C2TGU3_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Protein scribble homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">SCRIB</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell junction</location>
            <location evidence="4">Adherens junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Lamellipodium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Postsynapse</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="19">Presynapse</location>
        </subcellularLocation>
    </comment>
    <dbReference type="Ensembl" id="ENSCJPT00005019363.1">
        <property type="protein sequence ID" value="ENSCJPP00005013481.1"/>
        <property type="gene ID" value="ENSCJPG00005010729.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154025"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044291">
        <property type="term" value="C:cell-cell contact zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001772">
        <property type="term" value="C:immunological synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035748">
        <property type="term" value="C:myelin sheath abaxonal region"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034750">
        <property type="term" value="C:Scrib-APC-beta-catenin complex"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:auditory receptor cell stereocilium organization"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008283">
        <property type="term" value="P:cell population proliferation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0021747">
        <property type="term" value="P:cochlear nucleus development"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035089">
        <property type="term" value="P:establishment of apical/basal cell polarity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001768">
        <property type="term" value="P:establishment of T cell polarity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045197">
        <property type="term" value="P:establishment or maintenance of epithelial cell apical/basal polarity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046007">
        <property type="term" value="P:negative regulation of activated T cell proliferation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045930">
        <property type="term" value="P:negative regulation of mitotic cell cycle"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001843">
        <property type="term" value="P:neural tube closure"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098968">
        <property type="term" value="P:neurotransmitter receptor transport postsynaptic membrane to endosome"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098887">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030859">
        <property type="term" value="P:polarized epithelial cell differentiation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050918">
        <property type="term" value="P:positive chemotaxis"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010718">
        <property type="term" value="P:positive regulation of epithelial to mesenchymal transition"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001921">
        <property type="term" value="P:positive regulation of receptor recycling"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032729">
        <property type="term" value="P:positive regulation of type II interferon production"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036342">
        <property type="term" value="P:post-anal tail morphogenesis"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071896">
        <property type="term" value="P:protein localization to adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043113">
        <property type="term" value="P:receptor clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048488">
        <property type="term" value="P:synaptic vesicle endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016080">
        <property type="term" value="P:synaptic vesicle targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042060">
        <property type="term" value="P:wound healing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd06704">
        <property type="entry name" value="PDZ1_Scribble-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06703">
        <property type="entry name" value="PDZ2_Scribble-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06702">
        <property type="entry name" value="PDZ3_Scribble-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06701">
        <property type="entry name" value="PDZ4_Scribble-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000064">
        <property type="entry name" value="protein lap4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000041">
        <property type="entry name" value="protein scribble homolog isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000114">
        <property type="entry name" value="protein scribble homolog isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000338">
        <property type="entry name" value="protein scribble homolog isoform X12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000074">
        <property type="entry name" value="protein scribble homolog isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050614">
        <property type="entry name" value="Synaptic_Scaffolding_LAP-MAGUK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119">
        <property type="entry name" value="DISCS LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119:SF57">
        <property type="entry name" value="PROTEIN SCRIBBLE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0965">Cell junction</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="17" id="KW-0966">Cell projection</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="11" id="KW-0221">Differentiation</keyword>
    <keyword evidence="9" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="18" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0564">Palmitate</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0770">Synapse</keyword>
    <feature type="domain" description="PDZ" evidence="23">
        <location>
            <begin position="654"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="23">
        <location>
            <begin position="785"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="23">
        <location>
            <begin position="927"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="23">
        <location>
            <begin position="1023"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="433"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="590"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="753"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="872"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1191"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1356"/>
            <end position="1379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1416"/>
            <end position="1444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1465"/>
            <end position="1485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="22">
        <location>
            <begin position="606"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="755"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="1191"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="22">
        <location>
            <begin position="1206"/>
            <end position="1215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00034106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00034110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00072775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005013481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1485" mass="162669" checksum="0031A8818FDC8B5A" modified="2022-01-19" version="1">MQGRQQTAQRGLHVVSIPSLPCVLQGKQPLAETRWWSCADPPVLFVSQPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDISRNGKVRAPRPTAPRLCAPALKQPFPFGRGWSCERPLVVLRLRLVPAVPFPCNRFFPNIPEIPESIKFCKSLEIQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENKLEQLPNEVSGLVALTDLLLSQNLLEGIPDGIGQLKQLSILKVDQNRLTEVTESIGDCENLSELILTENMLTALPKSLGKLTKLTNLNVDRNRLTSLPAEIGGCSNLNVLSLRDNRLALLPAELANTTELHVLDVAGNRLQNLPFALTNLNLKALWLAENQSQPMLKFQTEDDEKTGEKVLTCYLLPQQPSPSLENLLQNSVDESWTDTNLNRVSVIQFLDDPKGDDEEEAGAERRGLQRRATPHPSELKVMKKVIEVRRSEVSAAKPGADPNSSNSEVSAYKVELLALPVLELEGGCLAVIPGSQPFWAFVLQPTVHFAEDTLIRSEDEDEDEERPFPVEKQRLIRKDTPHYKKHFKITKLPKPEAVVALLQGLNSDGVPKEEEELGGCNNNAEPEDEEEAWDEDDRKNGSLSAQPSVKGVSFDQANNLLIEPARIEEEELTLTIVRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAGVRVGDKLLEVNGVSLHCAEHHVAVEALRGSGSSVSMTVLRERMVEPENAITVTPLRPEDDYSPRERRGGLRFPERPEGAPPTERYSTCLMRNEKGLGFSIAGGKGSTPYRAGDTGIFISRIAEGGAAHRDGILHVGDRVISINGVDMTEARHDQAVALLTASSPTIVLLVEREGAEQPDEGDAPGAPWVRMHSPPPPPSHGESPPEETPSLQRSQLSKGLEDQYPIEEIHLVKAGGPLGLSIVGGSDHSSHPFGIHEPGVFISKVIPRGLASRSGLRVGDRILEVNSIDLRHATHQEAVNALLSNTQELTVVVRRDPPPPGMQEICIEKAPGEKLGISIRGGAKGHAGNPFDPTDEGIFISKVSSSGAAARDGRLKVGMRILEVNHQSLLGMTHTEAVQILRSVGDALLVLVCDGFDPKAAAAIEMSPGIIANPFAAGIGRKNSLESISSIDRDLSPEELEVLQKVGVLVTAGRVVEPLRMDYRTLAALPSSGSQRVNRTVSDGCRPKPPSPPSPDEIPINVKQAYKTFAAVPLSHPLLETQVTSGLHSPEQRSFRERQKYFEVEVKQQQVDKPPKRVSLVGEDDLKKMKEEEARKLQQKRTLLLEEEAEEDEMVKQVPEMSMAACFSLLLSLRRLSPLSLAAGDALAPVRTAKAERRHQERLRMQSPELLSSQEKELSPAERRALEAEKRAMWRAARMKSLEQDALKAQMVIAKSKEGKKRSTLEQVTESPSPVPTPSPTPLEGNAWGGNYLSLLLQRYVEDRNNSGKPMANGDSSVLLTSHPCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TI72</accession>
    <name>A0A8C2TI72_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTG anti-proliferation factor 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BTG4</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BTG family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TI72"/>
    <dbReference type="Ensembl" id="ENSCJPT00005020028.1">
        <property type="protein sequence ID" value="ENSCJPP00005014006.1"/>
        <property type="gene ID" value="ENSCJPG00005011750.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182952"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.90:FF:000002">
        <property type="entry name" value="BTG anti-proliferation factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.90">
        <property type="entry name" value="Anti-proliferative protein, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002087">
        <property type="entry name" value="Anti_prolifrtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033332">
        <property type="entry name" value="BTG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036054">
        <property type="entry name" value="BTG-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22978">
        <property type="entry name" value="B-CELL TRANSLOCATION GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22978:SF5">
        <property type="entry name" value="PROTEIN BTG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07742">
        <property type="entry name" value="BTG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00310">
        <property type="entry name" value="ANTIPRLFBTG1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00099">
        <property type="entry name" value="btg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160696">
        <property type="entry name" value="BTG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anti-proliferative protein" evidence="2">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005014006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="215" mass="25316" checksum="BFDA4CD4D8F64FC6" modified="2022-01-19" version="1">MKDEIAATVFFITRLIKREDKLSKHKVERFAAKLTTLLFEKYKNHWYLDNPSRGQAFRCIRINKHQARDPLLEQACVESNVDFNKLGLPKEMTLWVDPFEACYWRYGEKNRPFTLSQQINYAVDRAALDYPSGTSSDEESFSREPKAIPTVSNPNSVYQFDYCKTPVQSWSQYLHRKTHMSGSSYAQHRAYKAFRPTVAFTGPRVDRYHWINTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TIR5</accession>
    <name>A0A8C2TIR5_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="29" type="primary">KAT6B</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="29" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="29" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005018616.1">
        <property type="protein sequence ID" value="ENSCJPP00005012910.1"/>
        <property type="gene ID" value="ENSCJPG00005010910.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157372"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070776">
        <property type="term" value="C:MOZ/MORF histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036408">
        <property type="term" value="F:histone H3K14 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15618">
        <property type="entry name" value="PHD1_MOZ_MORF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15527">
        <property type="entry name" value="PHD2_KAT6A_6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000123">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000132">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000035">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.60:FF:000002">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005818">
        <property type="entry name" value="Histone_H1/H5_H15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048589">
        <property type="entry name" value="SAMD1-like_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF73">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21524">
        <property type="entry name" value="SAMD1_WH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00526">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51504">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52014">
        <property type="entry name" value="SAMD1_WH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0007">Acetylation</keyword>
    <keyword evidence="16" id="KW-0010">Activator</keyword>
    <keyword evidence="19" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="13" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="23" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="17" id="KW-0804">Transcription</keyword>
    <keyword evidence="15" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 22" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SAMD1-like winged helix (WH)" evidence="28">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="H15" evidence="26">
        <location>
            <begin position="103"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="25">
        <location>
            <begin position="213"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="25">
        <location>
            <begin position="269"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="MYST-type HAT" evidence="27">
        <location>
            <begin position="715"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="361"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="443"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1008"/>
            <end position="1476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1511"/>
            <end position="1555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1607"/>
            <end position="1626"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="23">
        <location>
            <begin position="980"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="447"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="470"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="24">
        <location>
            <begin position="488"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="24">
        <location>
            <begin position="501"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="1011"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="24">
        <location>
            <begin position="1079"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="24">
        <location>
            <begin position="1100"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="1159"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="1194"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="1251"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="1300"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="24">
        <location>
            <begin position="1349"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="1379"/>
            <end position="1394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="1395"/>
            <end position="1413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="1449"/>
            <end position="1469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="1511"/>
            <end position="1528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="24">
        <location>
            <begin position="1531"/>
            <end position="1551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="1610"/>
            <end position="1626"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="21">
        <location>
            <position position="891"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
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    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
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    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS51504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS52014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005012910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="2011" mass="224384" checksum="CE18254590179A49" modified="2022-01-19" version="1">MVKLANPLYTEWILEAIQKVKKQKQRPSEERICHAVCASHGLDKKTVSEQLQLSVQDGSILKVTNKGLASYKDPDNPGRFSSVKPGTIPKSVKGSRGACNELRNVDWNKLLRRAIEGLQEPSGSSLKNIEKYLRSQNDLANIFNNPAFQQRLRLGAKRAVNNGRLLKDGPQYRVNYGGLESKGAPKYSSGFPASLPPVSLLPHEKDQPRADPIPICSFCLGTKESNREKKPEELLSCADCGSSGHPSCLKFCPELTSNVKALRWQCIECKTCSACRIQGKNADNMLFCDSCDRGFHMECCDPPLSRMPKGMWICQVCRPKKKGRKLLHEKAAQIRRRYAKPIGRPKNKLKQRMLSVTSDEGSVNAFTGRGSPGRGQKTKVCTTPSSGHAASVKDSSSRLPVTDPTRPGATTKITTTSTYISASTLKVNKKTKGLIDGLTKFFTPSPDGRRSRGEIIDFSKHYRPRKKVSQKQSCTSLVLATGTTQKLKPPPSSLLPPTPISGQSPTSQKSSTSTSSDSPQSSSSQSSAPSFSRLPSNSQLKGLFDGLSHICATQEQFQNKGHPSYAPPKHMHCKPELFSTSKSASHYYRRKEVRNRFIPHACLSGWGLSRGPAFKAVAHLKRTTLLKKHRILGRLKYKVTPQMGTPSTGKGSWADGRIKPDQDDDTEIKLSIKQENTDVYLVGSKDTVTQEDLDVFKQARELSLEKIGCKNTGETSGRYPSVIEFGKYEIQTWYSSPYPQEYARLPKLYLCEFCLKYMKSKNILLRHSKKCGWFHPPANEIYRRNDLSVFEVDGNVSKIYCQNLCLLAKLFLDHKTLYYDVEPFLFYVLTKNDEKGCHLVGYFSKEKLCQQKYNVSCIMIMPQYQRQGFGRFLIDFSYLLSRREGQAGSPEKPLSDLGRLSYLAYWKSVILEYLNSTGMCPHDIATTLQQHSMIDKREDRFVIIRREKLISSHMEKLKANPRINEVDPESLRWTPLLVSNAAVSEEEREAEKEAERLMEQASCWEKEEQEIFSTRSNSRQSPAKVQSKNKYLRSPENVAVVGERGQSTEQSKESSEEDGGDESRQSSPPRLTKPQSLAMKRKRPFLLKKKRGRKRRRINSSVTTETISETTEVLNEPFDNSDEERPMPQLEPTCEMDGEDDDLKPVIRKTFEYQSGQQKQEKEEEQKKEEKDIHCLRSDDRCTDNTEDVAVLEESTKDNLEPSKSKQGWPKGIKRGPSKWRQNKERKPGFKLNLYTPPETPMEPDYQLLVEEQKEVAEDKPCPVPAVTEEEIKEPVDVLPPPDDEVKEVEPEPLHPPGEPYEKQENDAVEPGEKERNVEDSEINSKDPEKDKPEEDFLQKEESMHLDDHDEEEEDDEEPSHNEDHDADDEDDSHMGSAEVEKENLPAEAFKEMLETQQSFLDVNVQTGNSNQEDLMDCGVDLAADECESDQKEVATDSDPVPESDDDHTENNQDQKAGEELHSDFKGESNETMEIDSETVQAVQSLTQEASEQEDTFQDCAETQEACRSLQNYARTDQSPQMTTLDDCQQSDHSSPVSSVHSHPSQSVRSVNSPNVAPLESNYAQISPDQSAISVPSLQNMETSPMMDVPSVSDHSQQVVDSGFSDLGSIESTTENYENPSSYDSTMGSSICGNNSSQNSCSYSSLTSSNLTQSSCAVTQQMSNINGSCSMMQQTSISSPPTCNVKSPQGCVVERPPSSNQQLSQCSMAANFTPPMQLTEIPEAGNANIGLYERMGQSEFGPGHYSQPSATFSLAKLQQLTNTLMDHSLPYSHSPAVTSYANSASLSTPLSNTGLVQLSQSPHAVPGGPQAQATMTPPPNLTPPPMNLPPPLLQRNMTSSNIGISHTQRLQTQMASKGHVSVRTKSAPLPPAAAAHQPQIYGRASQTVAMQGPTRTLTMQRGMNMSVNLMPAPAYNVNSVNMNMNTLNAMNGYSMSQPMMNSGYHSNHGYMNQTPQYPMQMQMGMMGTQPYAQQPMQTAPHSNMMYSPPGHHGYMNTGMSKQSLNGSYMRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TIX1</accession>
    <name>A0A8C2TIX1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Origin recognition complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">ORC1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase. Interacts with CDC6 and KAT7/HBO1. Interacts with LRWD1 predominantly during the G1 phase and with less affinity during mitosis, when phosphorylated.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">ORC is composed of six subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the ORC1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015726053.1">
        <property type="nucleotide sequence ID" value="XM_015870567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015726054.1">
        <property type="nucleotide sequence ID" value="XM_015870568.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015726055.1">
        <property type="nucleotide sequence ID" value="XM_015870569.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TIX1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005020319.1">
        <property type="protein sequence ID" value="ENSCJPP00005014234.1"/>
        <property type="gene ID" value="ENSCJPG00005011895.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107317640"/>
    <dbReference type="KEGG" id="cjo:107317640"/>
    <dbReference type="CTD" id="4998"/>
    <dbReference type="GeneTree" id="ENSGT00530000063498"/>
    <dbReference type="OrthoDB" id="1926878at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04719">
        <property type="entry name" value="BAH_Orc1p_animal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08768">
        <property type="entry name" value="Cdc6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000062">
        <property type="entry name" value="Origin recognition complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.490:FF:000010">
        <property type="entry name" value="Origin recognition complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000199">
        <property type="entry name" value="Origin recognition complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015163">
        <property type="entry name" value="Cdc6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054425">
        <property type="entry name" value="Cdc6_ORC1-like_ATPase_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050311">
        <property type="entry name" value="ORC1/CDC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763:SF23">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01426">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22606">
        <property type="entry name" value="Cdc6-ORC-like_ATPase_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09079">
        <property type="entry name" value="WHD_Cdc6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00439">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01074">
        <property type="entry name" value="Cdc6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAH" evidence="15">
        <location>
            <begin position="43"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="204"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="357"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="398"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="212"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="402"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00046605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005014234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="856" mass="96679" checksum="C2060363F00F8151" modified="2022-01-19" version="1">MDACQQNKVVHSWYGQPMNSDRKLRILQYKGILIKSERSRKERCIQLGDFVLVEGENADQPFVAQLLDLYEDGAQRKHAVVQWFSHITEIPKNKQKLLKRRISFQEVFFDQVSGYDTDIAVETIIDSALVVPLRLKDELPTRLKKEKIFCVKQSWDGKCFKALSPHTFTKLNEANKKGDGVPNTFNSSVPSDIVSSVKKDNKKASWSATKQKNVEMEIESKHSASKSSLSKKTHSLRTANEFKNPSARKKLELNSPTRSPKSKLLDKDVLELLDDDYDFESLKPTPIKRKVKFTEVPSSPPKIHCASDKLKSVFGTAEHEEIFSGTLRLSPYRKAEDSNEKVKKLNMEDDAIVLTGHKELGSQSPAVTPRSRRTCAQETSTRIAEQISLLNMLESKEEDDFLSSSDSYSSSSEEEDSDVSCTPEKKTKSNGMFSTPRSSRKPSVHTPAKTSRKTPLPGTPRTPRNATPEIPKRSHAAQKPTSVLEEARLRLHVSAVPESLPCREEEFQDIYNFVESKLIDGTGGCMYISGVPGTGKTATVHEVIRCLQRATEDDDLPSFQFIEINGMKLTDPHQAYVQILELLTGQKVTATHAAVLLAKLFCTPGPKRKTTVLVVDELDLLWTRKQNVMYNLFDWPNQKHSKLIILAIANTMDLPERIMMNRVSSRLGLTRMSFQPYTYKQLQEIVSSRLNSVKAFEEDAIQLVSRKVAALSGDARRCLDICRRAAEICEFSSQKNSPEIVRMTHVTQAIDEMFSSPYIEAIRNASLHEQIFFKAILAEFRRAGVEEATVQQVYHQHISLCRMEGMQSPTVSDIVAICARLGACRLLLLDSSNKYLHMRVRLNVSQDDVMYALKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TJ32</accession>
    <name>A0A8C2TJ32_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAM192A/Fyv6 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TJ32"/>
    <dbReference type="Ensembl" id="ENSCJPT00005020482.1">
        <property type="protein sequence ID" value="ENSCJPP00005014380.1"/>
        <property type="gene ID" value="ENSCJPG00005012013.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00500000044916"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039845">
        <property type="entry name" value="FAM192A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019331">
        <property type="entry name" value="FAM192A/Fyv6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13495">
        <property type="entry name" value="NEFA-INTERACTING NUCLEAR PROTEIN NIP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13495:SF0">
        <property type="entry name" value="PSME3-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10187">
        <property type="entry name" value="FAM192A_Fyv6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM192A/Fyv6 N-terminal" evidence="4">
        <location>
            <begin position="16"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005014380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="109" mass="12940" checksum="E879ECA809C59EC8" modified="2022-01-19" version="1">MDGGDGSADLVINKRFVSEAELEERRKRRQEEWEKVRKPEDPEECPEEAYDPRSLYERLQEQREKKQQEFEEQFKFSKHQPLLLATKLSRLQQLNAASAGYVCMSYLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TKX6</accession>
    <name>A0A8C2TKX6_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cartilage intermediate layer protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">CILP2</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TKX6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005019022.1">
        <property type="protein sequence ID" value="ENSCJPP00005013194.1"/>
        <property type="gene ID" value="ENSCJPG00005011154.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000008152"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056257">
        <property type="entry name" value="CILP-1/2_8th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056256">
        <property type="entry name" value="CILP-1/2_b-sand_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056258">
        <property type="entry name" value="CILP-1/2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056255">
        <property type="entry name" value="CILP-1/2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039675">
        <property type="entry name" value="CILP1/CILP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025155">
        <property type="entry name" value="WxxW_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15031:SF0">
        <property type="entry name" value="CARTILAGE INTERMEDIATE LAYER PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15031">
        <property type="entry name" value="CARTILAGE INTERMEDIATE LAYER PROTEIN CLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23591">
        <property type="entry name" value="CILP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23708">
        <property type="entry name" value="CILP_5th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23730">
        <property type="entry name" value="CILP_8th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23599">
        <property type="entry name" value="CILP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13330">
        <property type="entry name" value="Mucin2_WxxW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="Carboxypeptidase regulatory domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034573415" evidence="7">
        <location>
            <begin position="27"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="302"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1137"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1148"/>
            <end position="1172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005013194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1172" mass="127928" checksum="B8652F9B785C3A45" modified="2022-01-19" version="1">MWWPPPGFPCHSTRCLCLLILPIAAPIYPHGAAPGMSLLIPYPGVTSVRSNGGLCAHGGLHAGGGAEWTSWFNIDHPGGDGDYESLDAIRFYYRGRVCARPVAIQARTTEWELPQDVGEVVHFSPKKGFRCVNKEQPQGKTCSNYHIRFLCPLEPMWTEWGSWGPCSRSCGSTGTRVRRRSCQNARKLLCAGHPSEVQQCPPSPCPGTCPGDTCPEHTLQGSVVSAAGSALPGARVYLEGRPPTLLARSDTRGAFRVSGLCVNIGANVSAHRDGFAPGLASVVSNGSGLLVAHVVLQKLEKPYMVLHPTPKVRVAGQEVTFCCKASGTPVPKKYHNGTLLDRMAHQYSSRLVLRALTPGQAGTYHCKASTEAGAIRSAPAQLTVLAQGQQSCKAAPEPSLVELPAECQQDAGGSRYYDVGHCPPTPCAGSPADGQRCGAGARRCCGVRRMEMREIRCGGSILPIKVVAKCGCGPCAQPRVLVQGRVTAADTGEPLRFGQIYLGKKKIGFTGFQGSFTIEVPPDTQRLVARFVDRQQRLVDAIKVLPFDRRGGAVYQEVKMMRKKEAVELDAGQINAIPLGEASGQEPIAELIIPAGAFLHPSGEVFNGTVKASVTFLDPRDVATARAASSDLSFANADGEIVPLRTYGMFAVDFRDGDSGTALQTGPVEVRMDAGQIWMAEHLKKMKLWSLNPETGLWEEEGVLRPTKERRGRREERTFLIGNMEIRERRLFNLDVPEDRRCFVKVRAYSNEKFNPYEQLEGVVISLINLEPKPGFPANPRAWGRFDSVVTGPNGACLPAFCDARRPDAYTAYITATLGGEELEAVPSSPKLNPNAVGVSQPYLNKLGYRRLDHDDPDIKKTAFQVNVAKPDPNNIDETNGPIYPYRSLRECEEAPVSANHFRFYRVEVDKYEYNVVPFKESDLTSWTGDYLSWWPNPQEFRACFIKVRIEGPQEYMVRSRNEGGSHPRTIGQLYGLRDARSVRDAMRDGSSGACLEFKCSGMLYDQSLVDRTLVTVIPQGSCRRTAVNGLLRDYLARHPPVVDNNNTAAFTMLAPVDPLGHNYGIYTVTDQNPRLAKEIAIGRCFDGTSDGFSREMKSDAGTAVTFTCQERPAGRESFFQRLLTSPAEALDEIRREMGAGELAGVQAQPSVPPNSQTGPSVPSVGENQWGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TLV5</accession>
    <name>A0A8C2TLV5_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Tensin 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">TNS1</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Focal adhesion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PTEN phosphatase protein family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSCJPT00005022390.1">
        <property type="protein sequence ID" value="ENSCJPP00005015839.1"/>
        <property type="gene ID" value="ENSCJPG00005013082.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155400"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007044">
        <property type="term" value="P:cell-substrate junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010761">
        <property type="term" value="P:fibroblast migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01213">
        <property type="entry name" value="PTB_tensin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14560">
        <property type="entry name" value="PTP_tensin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09927">
        <property type="entry name" value="SH2_Tensin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000039">
        <property type="entry name" value="Tensin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000002">
        <property type="entry name" value="Tensin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1110:FF:000002">
        <property type="entry name" value="tensin-1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000010">
        <property type="entry name" value="tensin-1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013625">
        <property type="entry name" value="PTB"/>
    </dbReference>
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        <property type="entry name" value="Tensin_phosphatase"/>
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        <property type="entry name" value="Tyr_Pase_cat"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0727">SH2 domain</keyword>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TN12</accession>
    <name>A0A8C2TN12_COTJA</name>
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        <submittedName>
            <fullName evidence="7">Solute carrier family 38 member 3</fullName>
        </submittedName>
    </protein>
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        <name evidence="7" type="primary">SLC38A3</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TN12"/>
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        <property type="gene ID" value="ENSCJPG00005012223.1"/>
    </dbReference>
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        <property type="component" value="Chromosome 12"/>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015180">
        <property type="term" value="F:L-alanine transmembrane transporter activity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015182">
        <property type="term" value="F:L-asparagine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015186">
        <property type="term" value="F:L-glutamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005290">
        <property type="term" value="F:L-histidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015817">
        <property type="term" value="P:histidine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF22">
        <property type="entry name" value="SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="83"/>
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            <begin position="459"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="6">
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            <begin position="58"/>
            <end position="480"/>
        </location>
    </feature>
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    </evidence>
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        </source>
    </evidence>
    <sequence length="494" mass="54102" checksum="EA25B68F96298BB4" modified="2022-01-19" version="1">MEGPELPVQAEMVELVPNGKHTAALSTTNWQCGAPWVPPGSIPPLCHHPLFVTQFEGKTSFGMSVFNLSNAIMGSGILGLAYAMANTGIILFLFLLTAVALLSSYSIHLLLKSSGIVGIRAYEQLGFRAFGTPGKLAAAIAITLQNIGAMSSYLYIVKSEVPLVIQTFLNLEEKTTDWYLNGNYLVILVSVTIILPLALMKQLGKWGHEWAWDLGGMVAVIYKKFQIPCPLPEQEGNITIGINASLGGEHWDGPAAPLPPEVEACTPNFFTLNSQTAYTIPIMAFAFVCHPEVLPIYTELKDPSKKKMQCISNISITVMYLMYFLAALFGYLTFYGRVESELLHTYSRVDPFDVLILCVRVAVLTAVTLTVPIVLFPVRRAIQQMLFQGKNFSWIRHIAIAVILLTFINLLVIFAPSILGIFGLIGATSAPCLIFIFPAIFYIRIMPKDKEPLRSTPKILAACFALLGVLFMIMSLSFIITDWATGGGRSGGSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TNM1</accession>
    <name>A0A8C2TNM1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="36">Activated CDC42 kinase 1</fullName>
            <ecNumber evidence="10">2.7.10.2</ecNumber>
            <ecNumber evidence="11">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="37">Tyrosine kinase non-receptor protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="45" type="primary">TNK2</name>
    </gene>
    <organism evidence="45 46">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="45" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="45" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="45" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="34">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="33">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell junction</location>
            <location evidence="8">Adherens junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
            <location evidence="7">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasmic vesicle membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasmic vesicle</location>
            <location evidence="3">Clathrin-coated vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Membrane</location>
            <location evidence="9">Clathrin-coated pit</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="35">Belongs to the protein kinase superfamily. Tyr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="10"/>
    <dbReference type="EC" id="2.7.11.1" evidence="11"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2TNM1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005023281.1">
        <property type="protein sequence ID" value="ENSCJPP00005016573.1"/>
        <property type="gene ID" value="ENSCJPG00005013610.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000165248"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042059">
        <property type="term" value="P:negative regulation of epidermal growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045616">
        <property type="term" value="P:regulation of keratinocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05040">
        <property type="entry name" value="PTKc_Ack_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09539">
        <property type="entry name" value="SAM_TNK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14274">
        <property type="entry name" value="UBA_ACK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14328">
        <property type="entry name" value="UBA_TNK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.680.10:FF:000001">
        <property type="entry name" value="activated CDC42 kinase 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000080">
        <property type="entry name" value="Putative activated CDC42 kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000107">
        <property type="entry name" value="Putative activated CDC42 kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.680.10">
        <property type="entry name" value="Cdc42-like binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055175">
        <property type="entry name" value="ACK/TNK-like_SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030220">
        <property type="entry name" value="Ack1_UBA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015116">
        <property type="entry name" value="Cdc42-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037085">
        <property type="entry name" value="Cdc42-bd-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052112">
        <property type="entry name" value="EGFR_SigReg_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021619">
        <property type="entry name" value="Mig-6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049587">
        <property type="entry name" value="TNK-like_SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14254">
        <property type="entry name" value="GENE 33 POLYPEPTIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14254:SF6">
        <property type="entry name" value="NON-SPECIFIC PROTEIN-TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09027">
        <property type="entry name" value="GTPase_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11555">
        <property type="entry name" value="Inhibitor_Mig-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22931">
        <property type="entry name" value="SAM_TNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="24 39 41" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="27" id="KW-0965">Cell junction</keyword>
    <keyword evidence="13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="30" id="KW-0168">Coated pit</keyword>
    <keyword evidence="15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="32" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="18" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="22" id="KW-0967">Endosome</keyword>
    <keyword evidence="23" id="KW-0418">Kinase</keyword>
    <keyword evidence="25" id="KW-0460">Magnesium</keyword>
    <keyword evidence="28" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0488">Methylation</keyword>
    <keyword evidence="21 39 41" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="31" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="46" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="12 40" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="19" id="KW-0808">Transferase</keyword>
    <keyword evidence="29" id="KW-0829">Tyrosine-protein kinase</keyword>
    <keyword evidence="26" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Protein kinase" evidence="44">
        <location>
            <begin position="187"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="43">
        <location>
            <begin position="449"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="42">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="42">
        <location>
            <begin position="142"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="42">
        <location>
            <begin position="568"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="42">
        <location>
            <begin position="692"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="42">
        <location>
            <begin position="817"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="42">
        <location>
            <begin position="607"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="42">
        <location>
            <begin position="826"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="38">
        <location>
            <position position="313"/>
        </location>
    </feature>
    <feature type="binding site" evidence="39">
        <location>
            <begin position="193"/>
            <end position="201"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="39 41">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00004536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00004600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00011903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="35">
        <source>
            <dbReference type="ARBA" id="ARBA00060742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="36">
        <source>
            <dbReference type="ARBA" id="ARBA00072244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="37">
        <source>
            <dbReference type="ARBA" id="ARBA00077194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="38">
        <source>
            <dbReference type="PIRSR" id="PIRSR630220-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="39">
        <source>
            <dbReference type="PIRSR" id="PIRSR630220-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="40">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="41">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="42">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="43">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="44">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="45">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005016573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="46">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1117" mass="125091" checksum="63048FA170B8A96E" modified="2022-01-19" version="1">MGERCDYQRLSSAEEEEEMLPPLPHSLSDSSGLRAPRMGSSRPGLPPQQDVTLGMACRRKLSCSMQAEEGTDWLLELLTELQLQQYFLRIRDELNVTRLSHFEYVKNEDLEKIGMGRPGQRRLWEAVKRRKAMCKRKSWMSKVFSGKRPDSELPPQPHSTFRKPPTPPPPDTGGQHSLTCLIRERDLSLFEKLGDGSFGVVRRGEWCTPAGKTLNVAVKCLKTDVLSQPEVLDDFIREVNAMHSLDHKNLIRLYGVVLSHPMKMVTELAPLGSLLDRLRKNQGHFLISTLCQYAIQVAKGMAYLESKRFIHRDLAARNILLASNELVKIGDFGLMRALPKNDDHYVMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDVYNVMLQCWAHKPEDRPTFVALRDFLVEAQPTDMRALQDFEEPDKLHIQMNDIITVIEGRAENYWWRGQNKRTLKVGQFPRNTVTSVAGLSAHDISQPLKNSFIHTGHGDTNPQQCWGFPDKIDELYLGNPMDPPDVLGVDLSTARPTQLPGRAKRQPPPRPPQPSILLTKPTYDPVSEEDEGLSAGLRKLCLKKPGPGKGLRLAKPSARVPGTKVGERQPGRSPSEGPTSSEVTLIDFGEEVPPTTPSPIGELTAPSLAKLAMEAFSLLDKTPPQSPTRALPRPLHPTPVVDWDARPLPPPPAYDDVAQDEDDFEVCSINSPLGQRGSRAGLPRARERGETNYGFVDEGERTAGLEDNLFLPPKDTKQPSLTQTTEIFQELQQECMKRFNVPQGPSACLADDKPQIPPRVPIPPRPLRRNEPGRWSGELSPASGGEEDRPPQIPPRDPLSQPTSRTPSPMALQVGSPQQRAALCSCLSTSPGKPMPTTQSFALDPKYATPKVIQAQGKDCSKGPCILPIVKDGQKVSSTHYYLLPERPAYLDKYEKFFKEAKSPEEAPASRVVTTATVRPMVQQQPDYKANFSSNNSNLGSKCLVKASCSLQKIVYDGPDGYRPSEKIRLVQDTVHGVTTEECQAALQNHGWNVQRAIQYLKVEQLFCLGLKSRVECHRVLEMFDWNLAQASSHLLDPYSSSRQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TNQ1</accession>
    <name>A0A8C2TNQ1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial</fullName>
            <ecNumber evidence="8">2.3.1.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Aminoacetone synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Glycine acetyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">GCAT</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>glycine + acetyl-CoA = (2S)-2-amino-3-oxobutanoate + CoA</text>
            <dbReference type="Rhea" id="RHEA:20736"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78948"/>
            <dbReference type="EC" id="2.3.1.29"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="7">
            <dbReference type="Rhea" id="RHEA:20738"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.29" evidence="8"/>
    <dbReference type="RefSeq" id="XP_015718334.1">
        <property type="nucleotide sequence ID" value="XM_015862848.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TNQ1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005023319.1">
        <property type="protein sequence ID" value="ENSCJPP00005016609.1"/>
        <property type="gene ID" value="ENSCJPG00005013633.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107314008"/>
    <dbReference type="KEGG" id="cjo:107314008"/>
    <dbReference type="CTD" id="23464"/>
    <dbReference type="GeneTree" id="ENSGT00940000155729"/>
    <dbReference type="OrthoDB" id="10263824at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008890">
        <property type="term" value="F:glycine C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06454">
        <property type="entry name" value="KBL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000004">
        <property type="entry name" value="2-amino-3-ketobutyrate coenzyme A ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000006">
        <property type="entry name" value="5-aminolevulinate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00985">
        <property type="entry name" value="2am3keto_CoA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011282">
        <property type="entry name" value="2am3keto_CoA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01822">
        <property type="entry name" value="2am3keto_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005394">
        <property type="entry name" value="PRK06939.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF102">
        <property type="entry name" value="2-AMINO-3-KETOBUTYRATE COENZYME A LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="12">
        <location>
            <begin position="67"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00052559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00067076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00069660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00075633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00078624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005016609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="419" mass="45224" checksum="FCC16C2AA445753B" modified="2022-01-19" version="1">MWRGAAVRAVRPTGGSRAASGAAAAQLRRWLEGELEGIRGAGTWKSERVIASRQGPHLRLEGGGAGILNFCANNYLGLSSHPQVIRAAVQALEEFGAGLSSVRFICGTQSIHKDLEEKIARFHQREDAILYASCFDANAGIFEALLTPEDAVLSDELNHASIIDGIRLCKANKYRYKHMDMHDLEAKLQDAQKHRLRLVATDGAFSMDGDIAPLREICQLAQKYDALVFIDECHATGFLGPNGRGTDELLGVMDKVTIVNSTLGKALGGAAGGYTTGPKPLIDLLRQRSRPYLFSNSLPPAVVGCASKALDLLMESNAIAQSMAAKTQRFRSKMTAAGFTISGKEHPICPVMLGDARLAAVMAEDMLSRGIYVIGFSYPVVPKGKARIRVQISAVHSDEDIDRCVEAFIEVGRKHGALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TPK1</accession>
    <name>A0A8C2TPK1_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BicC family RNA binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BICC1</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BicC family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TPK1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005020978.1">
        <property type="protein sequence ID" value="ENSCJPP00005014782.1"/>
        <property type="gene ID" value="ENSCJPG00005012305.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156276"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007368">
        <property type="term" value="P:determination of left/right symmetry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007507">
        <property type="term" value="P:heart development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001822">
        <property type="term" value="P:kidney development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd22420">
        <property type="entry name" value="KH-I_BICC1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22421">
        <property type="entry name" value="KH-I_BICC1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22422">
        <property type="entry name" value="KH-I_BICC1_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09520">
        <property type="entry name" value="SAM_BICC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000025">
        <property type="entry name" value="Ankyrin repeat and sterile alpha motif domain-containing 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.270:FF:000001">
        <property type="entry name" value="BicC family RNA binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.270:FF:000002">
        <property type="entry name" value="BicC family RNA binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054727">
        <property type="entry name" value="BICC1_KH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047549">
        <property type="entry name" value="BICC1_KH-I_rpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047554">
        <property type="entry name" value="BICC1_KH-I_rpt2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047553">
        <property type="entry name" value="BICC1_KH-I_rpt3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037974">
        <property type="entry name" value="BICC1_SAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627:SF78">
        <property type="entry name" value="PROTEIN BICAUDAL C HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627">
        <property type="entry name" value="SCP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22985">
        <property type="entry name" value="KH_BICC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24234">
        <property type="entry name" value="KH_BICC1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="SAM" evidence="7">
        <location>
            <begin position="961"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="12"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="771"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="875"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="95"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="780"/>
            <end position="793"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005014782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1062" mass="114086" checksum="8A4004A573DB466D" modified="2022-01-19" version="1">MEAEMLCGLRAGWGRRRAADAGPGPRSLGGEPEGEAGGGGGAGAGTLAGGGWDEAGGRLWGQIASRGEAAEWDSERRRGPPGSAMAAQCDPLSGYLQQPLSDPGSNSERSTDSPVPGSEEDSAGPPRPLHSPEWGEERFRVDRKKLEAMLQAAAEGKGKSGEDFFQKIMEETNTQIAWPSKLKIGAKSKKDPHIKVSGKKENVKEAKEKIMSVLDTKSNRVTLKMDVSHTEHSHVIGKGGNNIKKVMEETGCHIHFPDSNRNNQAEKSNQVSIAGQPAGVESARVRIRELLPLVLMFELPIAGILQPIPDPNSHTIQHISQTYNISVSFKQRSRMYGATVIVRGSQNNTSAVKEGTAMLLEHLAGSLASAIPVSTQLDIAAQHHLFMMGRNGSNIKHIMQRTGAQIHFPDPSNPQKKSTVYLQGTIESVCLARQYLMGCLPLVLMFDMKEEIEVEPQFITQLMEQLDVFISIKPKPKQPSKSVIVKSVERNALNMYEARKCLLGLESSGVTIASNASTVSCPVGLSCPGLDILSSAGLGLTGLGLLGPTALSVNTSTTPNSLLNALNSSVSPLQSPSSGTPSPALWTTSLANTNATGFSAIPHLMIPSTAQATLTSILLSGVPNYSQNTPSPPPGLTPVEVHVNGMQSESKKGSASLNGHVKTTNIKYAALSATSLGENVLSANHSDSARQTSSHVASEQVAAKTNGTEGCNDAFVEVGMPRSPSHSANTSDLKQMMSSSKQACAKRQTVELLQGTKNSHLHTTDRLLSDAELSASETPMADKKAPGSERAAERAAAAQQNSERARLAQPSYVNMQAFDYEQKKLLATKAMLKKPVVTEVRTPTNTWSGLGFSKSMPAETIKELRRANHVSYKPSMTTTYEGSSMSLSRSNSREHLGSGSESDNWRDRNGLGPTAHEFVSSIASPKRKQNRSAEHYLSSSNYMDCISSLTGSNGCNLNSLFKGSDLPELFSKLGLGKYTDVFQQQEIDLQTFLTLTDQDLKELGITTFGARRKMLLAISELNKNRRKLFDPSNIRASFLEGGASGRLPRQYHSDIASVSGRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TQI7</accession>
    <name>A0A8C2TQI7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Kin of IRRE-like protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Kin of irregular chiasm-like protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Nephrin-like protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">KIRREL1</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="13">Interacts with TJP1/ZO-1 and with NPHS2/podocin (via the C-terminus). Interacts with NPHS1/nephrin (via the Ig-like domains); this interaction is dependent on KIRREL1 glycosylation. Homodimer (via the Ig-like domains). Interacts when tyrosine-phosphorylated with GRB2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the immunoglobulin superfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TQI7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005023957.1">
        <property type="protein sequence ID" value="ENSCJPP00005017154.1"/>
        <property type="gene ID" value="ENSCJPG00005014030.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155795"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017022">
        <property type="term" value="F:myosin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045217">
        <property type="term" value="P:cell-cell junction maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003094">
        <property type="term" value="P:glomerular filtration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05759">
        <property type="entry name" value="IgI_2_KIRREL3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05898">
        <property type="entry name" value="IgI_5_KIRREL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000232">
        <property type="entry name" value="Kirre like nephrin family adhesion molecule 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000077">
        <property type="entry name" value="Kirre like nephrin family adhesion molecule 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000094">
        <property type="entry name" value="Kirre like nephrin family adhesion molecule 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000103">
        <property type="entry name" value="Kirre like nephrin family adhesion molecule 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000170">
        <property type="entry name" value="Kirre like nephrin family adhesion molecule 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640:SF14">
        <property type="entry name" value="KIN OF IRRE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="9 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="507"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="19">
        <location>
            <begin position="29"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="19">
        <location>
            <begin position="135"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="19">
        <location>
            <begin position="235"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="19">
        <location>
            <begin position="320"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="19">
        <location>
            <begin position="404"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="641"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="653"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00064586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00074376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00076239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00082444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005017154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="767" mass="83842" checksum="8C94E6A838D7336E" modified="2022-01-19" version="1">MAHGAEDSSGDHHDGALGSPNPIPHSLSPAAQTRFVEEPEDQTVVAGQRIVLSCVVLNYSGIVQWTKDGLALGMGQGLKAWPRYRIVGTADSGQYNLEISDAELSDDAVYECQATEAALRSRRAKLTVLIPPEDPTIDGAPEILLRAGTPYNLTCRARNAKPAATIVWYRDGLQQDGAITTTEVLADGKRETTTSLLTINPTDLDIGRIFSCRSTNDAIPAGKETFVKLNVHHPPTVTLSIQPQTVQEGERVVFTCMATANPEIKGYRWAKGGVIIEEAKENRYDTQVDYTFFTEPVSCEVHNDMGSTNISTLVDVHFAPRIMVAPKPTVTDIGSDVTLTCMWSGNPPLTLTWTKKESNMVLSNSNQLYLKSVTQADAGQYICKAIVPRIGVGEREVTLYVNGPPIISSEVVQYAARGDRGKVECFIGSTPPPDRIAWAWKENILEAGTLERYTVERTTMGSGVLSTLTINNVMEADFQTHYNCTAWNSFGPGTAIIQLEEKEVLPVGIIAGATIGASILVISFLVALACFLYRRRKGSRKDVTLRKLDIKVETVNREPLTLHADREEDTASVSTATRVMKAIYSSFKDDVDLKQDLRCDTIDTREEYELKDPTNGYYNVRAHEDRPASRTVLYADYRAPGPGRYDARPPSRLSHSSGYAQLNTYSRGPASEYSAEAAAGTGAPPGTAGGETASQLSYENYGGHTAFPAGGGYGGYRLGYGQPTSLERAPYDAYDPMGKYASATRFSYTSQHSDYGQRFQQRMQTHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TR86</accession>
    <name>A0A8C2TR86_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Extracellular leucine rich repeat and fibronectin type III domain containing 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">ELFN2</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="11">Interacts with PPP1CA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015718041.1">
        <property type="nucleotide sequence ID" value="XM_015862555.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TR86"/>
    <dbReference type="SMR" id="A0A8C2TR86"/>
    <dbReference type="Ensembl" id="ENSCJPT00005023342.1">
        <property type="protein sequence ID" value="ENSCJPP00005016631.1"/>
        <property type="gene ID" value="ENSCJPG00005013651.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107313887"/>
    <dbReference type="KEGG" id="cjo:107313887"/>
    <dbReference type="CTD" id="114794"/>
    <dbReference type="GeneTree" id="ENSGT00940000159737"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098839">
        <property type="term" value="C:postsynaptic density membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045184">
        <property type="term" value="P:establishment of protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099560">
        <property type="term" value="P:synaptic membrane adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000047">
        <property type="entry name" value="protein phosphatase 1 regulatory subunit 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055106">
        <property type="entry name" value="ELFN_Fn3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050541">
        <property type="entry name" value="LRR_TM_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369">
        <property type="entry name" value="ANTIGEN BSP, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369:SF204">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 29-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22986">
        <property type="entry name" value="Fn3_ELFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-0650">Protein phosphatase inhibitor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 14" id="KW-0732">Signal</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034059465" evidence="14">
        <location>
            <begin position="30"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="404"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="LRRCT" evidence="15">
        <location>
            <begin position="192"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="590"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00065735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005016631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="808" mass="90224" checksum="E9B88A59EC2B1C69" modified="2022-01-19" version="1">MKAPLKTMMCLGFWAAALLCLFSPGTVRGDCWLIEGDKGYVWLAICSQNQPPYETIPQHINSTVHDLRLNENKLKVVLYSSLNRFGNLTDLNLTKNEISYIEDGAFMGQTNLQVLQLGYNKLTNLTEGMLRGMARLQFLFVQHNLIELVTPTAFSECPSLISIDLSSNRLSRLEGNTFTSLSNLMVCELAGNPFNCDCSLYSFLNWLALFNNVTKNYDRLQCETPREFAGYPLLVPRPHHNRNAITIFQSMCRGGTIPSLSRVNPTPYTPDSQRDLDEGSAISPGDFLSVKPPASSTTDSSFSPSIKLHDVTITSAILMVTIPMPYSKMYVLVQYNNSYVSDIATLKSKKEYVTVNKLKAHTDYTFCVASIRNNRRYNHTCLTFATRSKGREDPISSTSTTTHYIMTTLGCLFGMVIVLGVVYYCLRKRRMQEEKQKSLNVKKTILEMRYGSDIDTSTMVHPSQKLGEPPVIPVSRMSSIPSMIGEKLPPPKSMETGMETPKVTTKGNYIEVRTGGGDGLERTPRDEDLRELDNGQGSAAEISTIAKEVDKVNQIINNCIDALKLDTASFLGGGTGVDSDMAFECQSIPASSSGGLERPSFLSPPYKESSHHPLQRQLSADAAVARKTCSVSSSGSIKSAKVFSLDVPDHPPLSKSDSKYIEKGSPLNSPLDRLPLVSPGAIHHLEVKPSYHCSEHRHSFPALYYEESADTLSQRVSFLKPLSRSKRDSTYSQLSPRHYFSGYSSSPEYSSESTHKIWERFRPYKKHHREEVYMAAGHALRKKVQFAKDEDLHDILDYWKGVSAQQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TRD1</accession>
    <name>A0A8C2TRD1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Lysosome-associated membrane glycoprotein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LAMP1</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Cytolytic granule membrane</location>
            <topology evidence="12">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Late endosome membrane</location>
            <topology evidence="11">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Lysosome membrane</location>
            <topology evidence="14">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the LAMP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TRD1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005023392.1">
        <property type="protein sequence ID" value="ENSCJPP00005016679.1"/>
        <property type="gene ID" value="ENSCJPG00005013682.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182899"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044754">
        <property type="term" value="C:autolysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101004">
        <property type="term" value="C:cytolytic granule membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
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        <property type="project" value="GOC"/>
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    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0042470">
        <property type="term" value="C:melanosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0061474">
        <property type="term" value="C:phagolysosome membrane"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="C:synaptic vesicle"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:ion channel inhibitor activity"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:protein domain specific binding"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:establishment of protein localization to organelle"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:Golgi to lysosome transport"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:granzyme-mediated programmed cell death signaling pathway"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:lysosomal lumen acidification"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:lysosomal lumen pH elevation"/>
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        <property type="term" value="P:positive regulation of natural killer cell degranulation"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:protein stabilization"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:proton transmembrane transport"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:regulation of organelle transport along microtubule"/>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="2.40.160.110:FF:000001">
        <property type="entry name" value="lysosome-associated membrane glycoprotein 2 isoform X2"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048528">
        <property type="entry name" value="Lamp2-like_luminal"/>
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        <property type="entry name" value="Lamp2-like_TM"/>
    </dbReference>
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        <property type="entry name" value="LAMP_CS"/>
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    <dbReference type="InterPro" id="IPR002000">
        <property type="entry name" value="Lysosome-assoc_membr_glycop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11506">
        <property type="entry name" value="LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11506:SF27">
        <property type="entry name" value="LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEIN 1"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF01299">
        <property type="entry name" value="Lamp2-like_luminal"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Lamp2_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00336">
        <property type="entry name" value="LYSASSOCTDMP"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00310">
        <property type="entry name" value="LAMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00311">
        <property type="entry name" value="LAMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51407">
        <property type="entry name" value="LAMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 14" id="KW-0458">Lysosome</keyword>
    <keyword evidence="7 14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 14 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="339"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Lysosome-associated membrane glycoprotein 2-like luminal" evidence="17">
        <location>
            <begin position="174"/>
            <end position="321"/>
        </location>
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    <feature type="domain" description="Lysosome-associated membrane glycoprotein 2-like transmembrane" evidence="18">
        <location>
            <begin position="341"/>
            <end position="372"/>
        </location>
    </feature>
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        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="161"/>
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        </location>
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        <location>
            <begin position="102"/>
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    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="188"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="295"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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            <dbReference type="ARBA" id="ARBA00022692"/>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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            <dbReference type="Pfam" id="PF21222"/>
        </source>
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        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005016679.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="374" mass="40440" checksum="CE4BEB9EA07E0E3A" modified="2022-01-19" version="1">GDVTKILKKFAHFFLPQNATSQSLSSCGEGNASHPVLALGFGAGHLIRLDFSKTPDEYQVEELIFYYNLSDETLFPNASEGKVMEATQKSVIQARIGTEYRCINSKNIHMKHVNVTFSNVTLEAYPTNGTFSTNKTECREDMVSTTTVASTTSKHITSQVPTTSPAPTTAPSSPAVGKYNVTGANGTCVLASMGLQLNITYLKKDEKVGLDLLNFVPGNTIASGTCENTSAFLNLAFEKTKITFHFVLNATSEKFFLQGVKVSTTLPSEAKAPTFEASNDSMNELRASVGNSYKCSAEENLQVTDKALVNVFNVQVQAFKVDGDKFGAVEECQLDENNMLIPIIVGAALAGLVLIVLIAYLIGRKRSHAGYQTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TRP1</accession>
    <name>A0A8C2TRP1_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Teashirt zinc finger homeobox 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">TSHZ3</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the teashirt C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015729569.1">
        <property type="nucleotide sequence ID" value="XM_015874083.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TRP1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005024636.1">
        <property type="protein sequence ID" value="ENSCJPP00005017670.1"/>
        <property type="gene ID" value="ENSCJPG00005014409.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107319343"/>
    <dbReference type="KEGG" id="cjo:107319343"/>
    <dbReference type="CTD" id="57616"/>
    <dbReference type="GeneTree" id="ENSGT00950000183051"/>
    <dbReference type="OrthoDB" id="5815793at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027008">
        <property type="entry name" value="Teashirt_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058631">
        <property type="entry name" value="TSHZ1-3_homeodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12487:SF5">
        <property type="entry name" value="TEASHIRT HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12487">
        <property type="entry name" value="TEASHIRT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26094">
        <property type="entry name" value="HTH_TSHZ3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="9 14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 14" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="275"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="16">
        <location>
            <begin position="887"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="1039"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="14">
        <location>
            <begin position="889"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="55"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="325"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="473"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="577"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="625"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="853"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="473"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="582"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="854"/>
            <end position="867"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005017670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1079" mass="118577" checksum="28DF8831F8D263DF" modified="2022-01-19" version="1">MPRRKQQAPRRAAAYVSDELKAAALVEEDVEADENTADGEPSAKYACPEKDFSKNCQSYQNSPAAEFSSHEMDSESHISETSDRMADFESSSIKNEEESKEVSIPLEDSTVSDSLEQMKAVYNNFLSNSYWSNLNLNLHQPISEKTNGSSSSSSSSSSSCGSGSFDWHQTAMAKTLQQVSQSRILPEPSLFSTVQLYRQSSKLYGSIFTGASKFRCKDCSAAYDTLVELTVHMNETGHYRDDNHETDNNNPKRWSKPRKRSLLEMEGKEDAQKVLKCMYCGHSFESLQDLSVHMIKTKHYQKVPLKEPVTPVAAKIIPATRKKASLELELPSSPDSTGGTPKAPVSDTNDALQKNSNPYITPNNRYGHQNGASYAWHFEARKSQILKCMECGSSHDTLQELTAHMMVTGHFIKVTNSAMKKGKPIIEAPATPTITSLVDEKVQSVPLAATTFTSPSNTPSSVSPKLNVEIKKEVDKERSTTDDKMKDKEKSSEDEEKYDISSKYHYLTENDLEESPKGGLDILKSLENTVTSAINKAQNGTPSWGGYPSIHAAYQLPNMMKLSLGSSGKSTPLKPMFGNNELVSPSKSQPLVSPPSSQTSPVPKTNFHAMEELVKKVTEKVAKVEEKMKEPEGKLSPMKRATPSPCSSEVSEPLKMEASNDGGFKSQQNSPVPQRDGCKDSPTVEPVENGKEPAKSIVGSLSSSTAIITDHPPEQPFVNPLSALQSVMNIHLGKAAKPSLPALDPMSMLFKMSNSLAEKAAVATPPLQSKKTDHLDRYFYHVNNDQPIDLTKGKSDKSCSLGSALLSSTSTSSASSSSTVTTAKTSAVVSFMSNSPLRENALSDISDMLKNLTESHTSKSSTPSSISEKSDIDGTTIEEPEESTPAQKRKGRQSNWNPQHLLILQAQFAASLRQTSEGKYIMSDLSPQERMHISRFTGLSMTTISHWLANVKYQLRRTGGTKFLKNLDTGHPVFFCNDCASQIRTPSTYISHLESHLGFRLRDLSKLSSEQINNQIAQAKSPSEKLVTSSPEEDIGTSYQCKLCNRTFASKHAVKLHLSKTHGKSPEDHLLYVSELEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TRW8</accession>
    <name>A0A8C2TRW8_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Meiotic recombination protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">DMC1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Participates in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Double stacked ring-shaped homooctamer. Interacts with BRCA2. Interacts with the MND1-PSMC3IP heterodimer. Interacts with RAD51AP1; the interaction is direct and stimulates DMC1-mediated homologous recombination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the RecA family. DMC1 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015718648.1">
        <property type="nucleotide sequence ID" value="XM_015863162.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015718659.1">
        <property type="nucleotide sequence ID" value="XM_015863173.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015718669.1">
        <property type="nucleotide sequence ID" value="XM_015863183.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015718678.1">
        <property type="nucleotide sequence ID" value="XM_015863192.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015718688.1">
        <property type="nucleotide sequence ID" value="XM_015863202.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032300667.1">
        <property type="nucleotide sequence ID" value="XM_032444776.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032300674.1">
        <property type="nucleotide sequence ID" value="XM_032444783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TRW8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005022816.1">
        <property type="protein sequence ID" value="ENSCJPP00005016203.1"/>
        <property type="gene ID" value="ENSCJPG00005013336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107314188"/>
    <dbReference type="KEGG" id="cjo:107314188"/>
    <dbReference type="CTD" id="11144"/>
    <dbReference type="GeneTree" id="ENSGT00760000119398"/>
    <dbReference type="OrthoDB" id="10251254at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000800">
        <property type="term" value="C:lateral element"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042148">
        <property type="term" value="P:DNA strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990918">
        <property type="term" value="P:double-strand break repair involved in meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007129">
        <property type="term" value="P:homologous chromosome pairing at meiosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007141">
        <property type="term" value="P:male meiosis I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001556">
        <property type="term" value="P:oocyte maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001541">
        <property type="term" value="P:ovarian follicle development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007286">
        <property type="term" value="P:spermatid development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd19514">
        <property type="entry name" value="DMC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000239">
        <property type="entry name" value="Meiotic recombination protein DMC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000032">
        <property type="entry name" value="meiotic recombination protein DMC1/LIM15 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011940">
        <property type="entry name" value="Dmc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016467">
        <property type="entry name" value="DNA_recomb/repair_RecA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010995">
        <property type="entry name" value="DNA_repair_Rad51/TF_NusA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003301">
        <property type="entry name" value="PRK04301.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02238">
        <property type="entry name" value="recomb_DMC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942:SF30">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN DMC1_LIM15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942">
        <property type="entry name" value="RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14520">
        <property type="entry name" value="HHH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005856">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47794">
        <property type="entry name" value="Rad51 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 11" id="KW-0469">Meiosis</keyword>
    <keyword evidence="3 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="13">
        <location>
            <begin position="99"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="RecA family profile 2" evidence="14">
        <location>
            <begin position="279"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00056818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00064395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR005856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005016203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="342" mass="38074" checksum="0FE822CC832D029E" modified="2022-01-19" version="1">MKAMEDQVVQEESGYQDDEESFFQDIDLLQKHGINVADIKKLKSVGICTIKGIQMTTRRALCNVKGLSEVKVDKIKEAANKLIEPGFLTAFEYSEKRKMVFHITTGSQEFDKLLGGGIESMAITEAFGEFRTGKTQLSHTLCVTAQLPGPNGYTGGKIIFIDTENTFRPDRLHDIADRFNVDHDAVLDNVLYARAYTSEHQMELLDYVAAKFHEEAGIFKLLIIDSIMALFRVDFSGRGELAERQQKLAQMLSRLQKISEEYNVAVFVTNQMTADPGATMTFQADPKKPVGGHILAHASTTRISLRKGRGELRIAKIYDSPEMPENEATFAITPGGIGDAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TTA8</accession>
    <name>A0A8C2TTA8_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chloride channel protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">CLCN2</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>thiocyanate(in) = thiocyanate(out)</text>
            <dbReference type="Rhea" id="RHEA:75347"/>
            <dbReference type="ChEBI" id="CHEBI:18022"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="22">Homodimer. Interacts with auxiliary subunit HEPACAM.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Basolateral cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Axon</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Dendritic spine membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the chloride channel (TC 2.A.49) family. ClC-2/CLCN2 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015727383.1">
        <property type="nucleotide sequence ID" value="XM_015871897.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TTA8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005023501.1">
        <property type="protein sequence ID" value="ENSCJPP00005016779.1"/>
        <property type="gene ID" value="ENSCJPG00005013763.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107318271"/>
    <dbReference type="CTD" id="1181"/>
    <dbReference type="GeneTree" id="ENSGT00940000155439"/>
    <dbReference type="OrthoDB" id="4564at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097450">
        <property type="term" value="C:astrocyte end-foot"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032591">
        <property type="term" value="C:dendritic spine membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043209">
        <property type="term" value="C:myelin sheath"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017081">
        <property type="term" value="F:chloride channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090425">
        <property type="term" value="P:acinar cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060689">
        <property type="term" value="P:cell differentiation involved in salivary gland development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006911">
        <property type="term" value="P:phagocytosis, engulfment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032347">
        <property type="term" value="P:regulation of aldosterone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060075">
        <property type="term" value="P:regulation of resting membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060041">
        <property type="term" value="P:retina development in camera-type eye"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd04591">
        <property type="entry name" value="CBS_pair_voltage-gated_CLC_euk_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03683">
        <property type="entry name" value="ClC_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3080.10:FF:000002">
        <property type="entry name" value="Chloride channel 2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.580.10:FF:000102">
        <property type="entry name" value="Chloride channel, voltage-sensitive 2a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.580.10:FF:000019">
        <property type="entry name" value="Chloride voltage-gated channel 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002244">
        <property type="entry name" value="Cl-channel-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050970">
        <property type="entry name" value="Cl_channel_volt-gated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45720">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45720:SF6">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01113">
        <property type="entry name" value="CLCHANNEL2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="20" id="KW-0966">Cell projection</keyword>
    <keyword evidence="18" id="KW-0868">Chloride</keyword>
    <keyword evidence="17" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="16 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0770">Synapse</keyword>
    <keyword evidence="9 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 24" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="11" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="456"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="498"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="675"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="866"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="23">
        <location>
            <begin position="682"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00036895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00046437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005016779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="885" mass="97650" checksum="1DA2083C4674FE8B" modified="2022-01-19" version="1">MASAESAEQRALQYEQTLMYGRYTQDLGTFAKDEAARLRLKQEHEDSGTPRPRRPSELLEYSQGRCAPCCGCAVRCQRFFIARVGEDWVFLILLGLVMALVSWAMDFAIATCLQAQKWMYGGLDTNVMLQYLAWVTYPTVLITFSAGFTQILAPQAVGSGIPEMKTILRGVVLKEYLTLKTFVAKVIGLTCALGSGMPLGKEGPFVHIASMCAALLSRFLSFFGGIYENEARNTEMLAAACAVGVGCCFAAPIGGVLFSIEVTSTFFAVRNYWRGFFAATFSAFIFRVLAVWIKDEETITALFKTRFRLDFPFDLQELPAFAVIGIASGFGGALFVYLNRKIVQCMRRQKTINRFLMKKRLLFPALVTLLISTLTFPPGFGQFMAGQLTQKDTLVTLFDNRTWAKREPSDEFEYLGILEAWRHPRSNVFVTLVVFIIMKFWMSALATTIPVPCGAFMPVFVIGAAFGRLVGESMAAWFPDGIHTDSNTYRIVPGGYAVVGAAALSGAVTHTVSTAVIVFELTGQISHILPVMIAVILANAVAQSLQPSLYDSIIRIKKLPYLPELGWGHHEKYNMRVEDIMVRDVPYVSLNCKYRDLQHVLQSTKMKSLALVDSAESMILLGSIERAQVGALLGQQLHPQRRLQALRQKAWASADDGRRFSEASVCFQISTEASSFTPTRSGSRKPLKPALKRVPSIPTDGSPASATDSSSIALKSLFCANSAAEPAEAQGQAPRKAKHVRISVTEDLDLGDRMTPAEILDWEEQQLEQSVDFSSAQIDPAPFQLVERTSLHKTHTIFSLLGLDHAYVTSIGRLVGMVSLKELRKAIEGSLTAKGVKVLPPLASFRRSSTSAGELDTTDLRQLWDRHQHHPMPREAGPDDGDTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TTN8</accession>
    <name>A0A8C2TTN8_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Keratin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC107324388</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the avian keratin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015739854.1">
        <property type="nucleotide sequence ID" value="XM_015884368.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TTN8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005024034.1">
        <property type="protein sequence ID" value="ENSCJPP00005017210.1"/>
        <property type="gene ID" value="ENSCJPG00005014077.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107324388"/>
    <dbReference type="KEGG" id="cjo:107324388"/>
    <dbReference type="GeneTree" id="ENSGT01030000234722"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005882">
        <property type="term" value="C:intermediate filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003461">
        <property type="entry name" value="Keratin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31203">
        <property type="entry name" value="BETA-KERATIN-RELATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31203:SF1">
        <property type="entry name" value="BETA-KERATIN-RELATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02422">
        <property type="entry name" value="Keratin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0416">Keratin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005017210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="153" mass="15517" checksum="985091803D6312BC" modified="2022-01-19" version="1">MSCYDLCPTNIGGISRPQPIANSGNEPCVRQCPDSTTVIQPPPVVVTFPGPILSSFPQDSVVGSSGAPVFGGFGGSSLGYGGLYGYGGSSLGYGGGLYGYGGSSLGYGGLCGYGGSSLGYGGLYGYGRSYGSGYCSPYSYRYNRYRRGSCGPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TV93</accession>
    <name>A0A8C2TV93_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="18">MORC family CW-type zinc finger 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">MORC2</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015733662.1">
        <property type="nucleotide sequence ID" value="XM_015878176.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TV93"/>
    <dbReference type="Ensembl" id="ENSCJPT00005024922.1">
        <property type="protein sequence ID" value="ENSCJPP00005017933.1"/>
        <property type="gene ID" value="ENSCJPG00005014569.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107321355"/>
    <dbReference type="KEGG" id="cjo:107321355"/>
    <dbReference type="CTD" id="22880"/>
    <dbReference type="GeneTree" id="ENSGT00940000153998"/>
    <dbReference type="OrthoDB" id="10251809at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000792">
        <property type="term" value="C:heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141005">
        <property type="term" value="P:transposable element silencing by heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd16931">
        <property type="entry name" value="HATPase_MORC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.100:FF:000001">
        <property type="entry name" value="MORC family CW-type zinc finger protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000027">
        <property type="entry name" value="MORC family CW-type zinc finger protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056360">
        <property type="entry name" value="Chromo_MORC2_6th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041006">
        <property type="entry name" value="Morc_S5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011124">
        <property type="entry name" value="Znf_CW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23337:SF7">
        <property type="entry name" value="ATPASE MORC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23337">
        <property type="entry name" value="ZINC FINGER CW-TYPE COILED-COIL DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23327">
        <property type="entry name" value="Chromo_MORC2_6th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17942">
        <property type="entry name" value="Morc6_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07496">
        <property type="entry name" value="zf-CW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51050">
        <property type="entry name" value="ZF_CW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CW-type" evidence="17">
        <location>
            <begin position="490"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="530"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="285"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="959"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="532"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="550"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="635"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="661"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="682"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005017933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1025" mass="116511" checksum="9CD0843AC77209AB" modified="2022-01-19" version="1">MSCANYSSLNRAQLTFEYLHTNSTTHEFLFGALAELVDNARDADATRIDIYTERRESLRGGFMLCFLDDGTGMDSNEAASVIQFGKSAKRSPESTQIGQYGNGLKSGSMRIGKDFILFTKKNNTMTCLLLSRTFHEEEGIDEVIVPLPTWNAWNREPVSDNMEKFAIETELIYKYSPFKSEQQVMEQFNKIRGEKGTLVIIFNLKLMDNGEPELDVTSDPRDIQMAETPPEGTKPERRSFRAYAAVLYIDPRMRIFINGHKVQTKRLSCCLYKPRMYKYTSNRFKTRAEQEVKKAEHMARIAEEKAREAESKARAFELRLGGDLTRESRVTLRQVQNSAITMRREADVKKRIKDAKQRALKEPKELNFIFGVNIEQRELDGMFIYNCSRLIKMYEKVGPQLEGGMACGGVVGVVDVPYLVLEPTHNKQDFADAKEYRHLLKAMGEHLAQYWKDVAIAQRGIIKFWDEFGYLSANWNQPPSSELRYKRRRAMEIPTTIQCDVCLKWRTLPFQLSSVEKNYPDSWVCSMNPDPEQNRCDAPEQKQKLPLGTLKKDSKSQEEKQKQLSEKIRQQQEKLEALQKTTPVRSQADLKKLPLEVTTRPAGEQVARSQRPRSPPLPDVIKNAPSRPPSFTLPSKSVSQLKKSSSTWTHINTPRLASILSKEEASTSKTHHDAVTVGRSNSTSKTLAKLTTATKPSSAAPQSPKSPREAPSSKTAKASTPKKSAIVKSPQASTPRKRSVQAAEELSEEEVECKKERTKRGKFVAVKEEKKDPSEVEVELTDSAGEEDVAELKKAQKDKGLHVEVRVNKEWFTGRVTAVEMGKHAVRWKVKFDYVPTDTTPRDRWVEKGSEDVRLMKPPSPEYQSPDTQQEEEVVVAEPSTSEYVGIEPDTTGPSSGQETVDLLVQILRNCLRYFLPPNFPISKKELSSMSSEGLLAFPLKDYFKQYEMGLQNLCNSYQTRADARAKACEENLRNTERKLKETEEKLQKLRTNIVALLQKVQEDIDINTDDELDAYIEDLITKGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TVB6</accession>
    <name>A0A8C2TVB6_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ribonuclease H</fullName>
            <ecNumber evidence="3">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC107321550</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2TVB6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005026906.1">
        <property type="protein sequence ID" value="ENSCJPP00005019430.1"/>
        <property type="gene ID" value="ENSCJPG00005015738.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153527"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001817">
        <property type="term" value="P:regulation of cytokine production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903037">
        <property type="term" value="P:regulation of leukocyte cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050863">
        <property type="term" value="P:regulation of T cell activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050852">
        <property type="term" value="P:T cell receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000142">
        <property type="entry name" value="V-set domain-containing T-cell activation inhibitor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
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        <property type="entry name" value="BG-LIKE ANTIGEN 1-RELATED"/>
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        <property type="entry name" value="RVT_1"/>
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        <property type="entry name" value="Immunoglobulin"/>
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        <property type="entry name" value="IG_LIKE"/>
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    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
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    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
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        <location>
            <begin position="1"/>
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            <begin position="35"/>
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        <source>
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        <source>
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    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
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    <sequence length="281" mass="31690" checksum="38BAD3F082749094" modified="2022-01-19" version="1">MGFTSGCNHPSFSHPWKTRLAHLLALHLLHLGSAQFRVVAPNHRVSAIVGQDVVLRCLLSPCKDAWSSDIRWVQHRSAGLVHHYQNGLDLEQMDEYKGRTELLRDGLSDGNLDLLITAVTSADSGSYICTVQDFDGYAYAVVKLEVSDPFCENEGPWKVALAVVIILLVGSALFNIFLYRKQGELRAEGTEHREVFCKGRQWTFQVLPQGYMHSPTYCHNLVVRDLANWEKPDNVYLYHYIDDLLLTSDSLEAVGEAADLLTAYLQKRGWAINQQNVQGYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TVB7</accession>
    <name>A0A8C2TVB7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">E3 ubiquitin-protein ligase MARCHF6</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Membrane-associated RING finger protein 6</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Membrane-associated RING-CH protein VI</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">MARCHF6</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Interacts with DIO2. Interacts with SQLE.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="RefSeq" id="XP_015709896.1">
        <property type="nucleotide sequence ID" value="XM_015854410.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TVB7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005025554.1">
        <property type="protein sequence ID" value="ENSCJPP00005018335.1"/>
        <property type="gene ID" value="ENSCJPG00005014940.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107309528"/>
    <dbReference type="CTD" id="10299"/>
    <dbReference type="GeneTree" id="ENSGT00940000155171"/>
    <dbReference type="OrthoDB" id="1108038at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990381">
        <property type="term" value="F:ubiquitin-specific protease binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045541">
        <property type="term" value="P:negative regulation of cholesterol biosynthetic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070936">
        <property type="term" value="P:protein K48-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd16702">
        <property type="entry name" value="RING_CH-C4HC3_MARCH6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000096">
        <property type="entry name" value="E3 ubiquitin-protein ligase MARCH6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056521">
        <property type="entry name" value="MARCHF6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13145:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCHF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13145">
        <property type="entry name" value="SSM4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23113">
        <property type="entry name" value="MARCHF6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="14" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="15 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="101"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="333"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="369"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="481"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="522"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="633"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="675"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="720"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="763"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="805"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="848"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="22">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00064724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00069012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00082010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00083917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005018335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="910" mass="102819" checksum="E941DAE3A9C7DE89" modified="2022-01-19" version="1">METAEEDICRVCRSEGTPEKPLYHPCVCTGSIKFIHQECLVQWLKHSRKEYCELCKHRFAFTPIYSPDMPSRLPIQDIFAGLVTSIGTAIRYWFHYTLVAFAWLGVVPLTACRIYKCLFTGSVSSLLTLPLDILSTENLLADCLQGCFVVTCTLCAFISLVWLREQIVHGGAPQWLEQNQQQPINGVGQQNEAQAVANGAVENAVLDQPANPAADIAVVGENPEIQEEQVDEEEEENEDEEDAVVEDAADANNGAQDDMNWNALEWDRAAEELTWERMLGLDGSLVFLEHVFWVVSLNTLFILVFAFCPYHIGHFSIVGLGFEEYVQASHFEGLITTIVGYVLLAVTLIVCHGLAALVKFQRSRRLLGVCYIVVKVSLLVVVEIGVFPLICGWWLDICSLEMFDATLKDRELSFQSAPGTTMFLHWLVGMVYVFYFASFILLLREVLRPGVLWFLRNLNDPDFNPVQEMIHLPIYRHLRRFILSVIVFGSIVLLMLWLPIRIIKYLLPNFLPYNVMLYSDAAVSELSLELLLLQVVLPALLEQGHTRQWLKGLVRAWTVTAGYLLDLHSYLLGDQEENENNANQQPNNHHARNNNAIPVVGEGLHAAHQAILQQGGPVGFQPYRRPLKFPLRIFLLIVFMCITLLIASLICLTLPVFAGRWLMSFWTGTAKIHELYTAACGLYVCWLTIRAVTVLVAWMPQGRRVIFQKVKEWSLMIMKTLIVAILLAGVVPLLLGLLFELVIVAPLRVPLDQTPLFCPWQDWALGVLHAKIIAAITLMGPQWWLKTVIEQVYANGIRNIDLHFIICKLAAPVISVLLLSLCVPYIIASGVVPLLGVTAEMQNLVQRRIYPFLLMVVVLMGILSFQVRQFKRLYEHIKNDKYLVGQRLVNYERKSGKQGTSTTPPQSSQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TVM8</accession>
    <name>A0A8C2TVM8_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Polymeric immunoglobulin receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">PIGR</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Mediates selective transcytosis of polymeric IgA and IgM across mucosal epithelial cells. Binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process, a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Through its N-linked glycans ensures anchoring of secretory IgA (sIgA) molecules to mucus lining the epithelial surface to neutralize extracellular pathogens. On its own (free form) may act as a non-specific microbial scavenger to prevent pathogen interaction with epithelial cells.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Interacts (mainly via CDR1-like domain) with dimeric IgA. Interacts (mainly via CDR2-like domain) with pentameric IgM.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015740597.1">
        <property type="nucleotide sequence ID" value="XM_015885111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TVM8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005025700.1">
        <property type="protein sequence ID" value="ENSCJPP00005018467.1"/>
        <property type="gene ID" value="ENSCJPG00005015043.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107324776"/>
    <dbReference type="KEGG" id="cjo:107324776"/>
    <dbReference type="CTD" id="5284"/>
    <dbReference type="GeneTree" id="ENSGT00950000182977"/>
    <dbReference type="OrthoDB" id="6157407at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05716">
        <property type="entry name" value="IgV_pIgR_like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050671">
        <property type="entry name" value="CD300_family_receptors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11860:SF82">
        <property type="entry name" value="POLYMERIC IMMUNOGLOBULIN RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11860">
        <property type="entry name" value="POLYMERIC-IMMUNOGLOBULIN RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="8 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 18" id="KW-0732">Signal</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034264490" description="Polymeric immunoglobulin receptor" evidence="18">
        <location>
            <begin position="31"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="527"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="19">
        <location>
            <begin position="265"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="19">
        <location>
            <begin position="371"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="491"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="631"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="507"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="631"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005018467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="660" mass="71963" checksum="969FA2CD151FA29E" modified="2022-01-19" version="1">MVCRSNLAWNARRMTLLASILLLSFLPAESAKSRYPPKSSLNPVFGPQQVYGLIDGSVSIKCFYPPTTVNRHDRKYWCRESSRSCPTVVSTSGFIAQGYKGRVTITDFPEQGVMLVNISQLNLADRGTYQCGIGLSGRGLSNRVSLDISEGPNLPEEAELFYVELHGSVSMSCDFGGDYASTRKFLCKMEKGGCRNIVDTYGKIDEDFQGRVLLSNENTEGAFSITITQVDWEDAGLYLCGVGSYGEYGETKELDLHVYEGTKAPQGKQTIFGVKGTSATIDCHYDPTKSYSLKYLCKWRTTGCARIIDNKGFVPGPYEGRVAMFDNPKNGTFSIILNQLRSNDEGFYWCMTDDQRERKTTKELKIIEGEPGLTGKQELQAQVGSRVDLTCSYTCKYYSYEKYWCKWSREGCTPLTASDPGLDVNCDIANKTIILSIDPVTVEDQGWYWCGVKRNGHYGETMAVSLQVDGGKAANISPELLDLEASNAAAAPAPNEAVPRGRANSDAGVQSAAASESSEQSSGSNTLALILGPVGAMLLVLATAFAVFKYRQIRRSDLVSVGSYRTNISMSDFENAKEYGANDNPCMKQSQETQLGGDEFVTTTVNVESTAETKKAKRNSKEDADLAYSASLLTPSTVTQSPAGDSTAPSEAPPLWGGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TVZ3</accession>
    <name>A0A8C2TVZ3_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyl-CoA synthetase family member 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ACSF3</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TVZ3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005025710.1">
        <property type="protein sequence ID" value="ENSCJPP00005018476.1"/>
        <property type="gene ID" value="ENSCJPG00005015048.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157000"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090409">
        <property type="term" value="F:malonyl-CoA synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031957">
        <property type="term" value="F:very long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090410">
        <property type="term" value="P:malonate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd05941">
        <property type="entry name" value="MCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000030">
        <property type="entry name" value="Acyl-CoA synthetase family member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF8">
        <property type="entry name" value="ACYL-COA SYNTHETASE FAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="4">
        <location>
            <begin position="56"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005018476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="593" mass="65308" checksum="DB2453661D027713" modified="2022-01-19" version="1">MLLSLLSPRVSWSARCLLRDLHRWGLRGQNRTGCPWRGIQTTRAASSHHVSPVFTKALTFGDKVAIVDQNGEHTYRELYCQSLRLSQEICRVLQCPSRDLKEERISFLCPNDASYVVAQWASWMSGGIAVPLYRKHPVQQLEYVIEDSQSALVITTEEYVGKISPSAEKLGVPVLPLGSHSSGSADHTAVEDVPLASSASWKDRGAMIIYTSGTTGRPKGVLSTHKNVQAVTTGLVEKWEWKKEDVILHVLPLHHVHGVINKLLCPLWVGATCIMLPEFSAQMVWKKFLSSQAPRVSVFMAVPTIYAKLIEYYDQHFSQPQVQDFVRAFCQENIRLMVSGSAALPVPVLKKWKAITGHTLLERYGMTEIGMALSNPLHGVRVPGSVGTPLPGVEVRIATETVKGSGRSYTIHAEGDEHGTQVTPGLEGQEGELLVRGSSVFREYWNRPKETKEAFTPDGWFRTGDTAAYHDGVYWIKGRTSVDIIKNGGFKISALEVERQLLSHPHITGEQSVGLWGCTGAHALSLQPGPVLRAALSAFGNEPPSLQPTSSALSPDVAVIGPPDVVWGQRVSAVVQLRKGEMLSVKELKEWAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TW16</accession>
    <name>A0A8C2TW16_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Carboxypeptidase M</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">CPM</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the peptidase M14 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015711727.1">
        <property type="nucleotide sequence ID" value="XM_015856241.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TW16"/>
    <dbReference type="Ensembl" id="ENSCJPT00005027263.1">
        <property type="protein sequence ID" value="ENSCJPP00005019718.1"/>
        <property type="gene ID" value="ENSCJPG00005015955.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107310518"/>
    <dbReference type="KEGG" id="cjo:107310518"/>
    <dbReference type="CTD" id="1368"/>
    <dbReference type="GeneTree" id="ENSGT00940000158580"/>
    <dbReference type="OrthoDB" id="10249045at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03866">
        <property type="entry name" value="M14_CPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11308">
        <property type="entry name" value="Peptidase_M14NE-CP-C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000041">
        <property type="entry name" value="Carboxypeptidase M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1120">
        <property type="entry name" value="Carboxypeptidase-like, regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057246">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033842">
        <property type="entry name" value="CPM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050753">
        <property type="entry name" value="Peptidase_M14_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11532:SF84">
        <property type="entry name" value="CARBOXYPEPTIDASE M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11532">
        <property type="entry name" value="PROTEASE M14 CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13620">
        <property type="entry name" value="CarboxypepD_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="Carboxypeptidase regulatory domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00132">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034959342" evidence="4">
        <location>
            <begin position="21"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="5">
        <location>
            <begin position="24"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005019718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="443" mass="49642" checksum="7B17FB1E7432C379" modified="2022-01-19" version="1">MRTGAGEAVGVLCLVSLVAALDYKYHHSEELEAYLKEVHAAHPAITHLHSIGRSVEGRDLWVLVLGRFPTQHKIGIPEFKYVANMHGDETVGREILLHLIDHLVTSYGRDPTITRLLNNTRIHIMPTMNPDGFEATVVPDCYYSRGRYNKNGEDLNRNFPDAFENNNNVIQPETQAVINWIKNETFVLSANLHGGALVASYTFDNGNSVTGTSNGYSRSPDDDVFIHLAKTYSFNHASMYKGIGCDSRPTFPDGITNGYSWYQLEGGMQDYNYVWGQCFEITLELSCCKYPPAEQLEKFWRDNRVALVEYIKQVHLGVKGQVTDKNGNPIPNAIVEAKGRPHICPYRTNEHGEYFLLLLPGKYVINATVPGFKSMLKTVDIPDNTANFSALKQDFSFPDVSVKPSPASCPRTPLYQELERTSAAVKPTLHILVLVMVTISIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TWN7</accession>
    <name>A0A8C2TWN7_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">EH domain containing 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">EHD4</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TWN7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005024744.1">
        <property type="protein sequence ID" value="ENSCJPP00005017772.1"/>
        <property type="gene ID" value="ENSCJPG00005014461.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158601"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002042">
        <property type="term" value="P:cell migration involved in sprouting angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09913">
        <property type="entry name" value="EHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000147">
        <property type="entry name" value="EH domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040990">
        <property type="entry name" value="DUF5600"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031692">
        <property type="entry name" value="EHD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216:SF57">
        <property type="entry name" value="EH DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18150">
        <property type="entry name" value="DUF5600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16880">
        <property type="entry name" value="EHD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="10">
        <location>
            <begin position="59"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="504"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005017772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="527" mass="59335" checksum="D896A396C41B6F5A" modified="2022-01-19" version="1">MFSWMGKQGGGRERGIGGSDIVQTVTGGLRDLYLRKLLPLEEHYRFHEFHSPALEDADFDNKPMVLLVGQYSTGKTTFIRYLLEQDFPGMRIGPEPTTDSFIAVMYGESEGSVPGNALVVDPKKPFRKLSRFGNAFLNRFLCSQLPNQVLKSISIIDSPGILSGEKQRISRGYDFCQVLQWFAERVDRIILLFDAHKLDISDEFSEAIKAFRGQDDKIRVVLNKADQVDTQQLMRVYGALMWSLGKVINTPEVLRVYIGSFWAQPLRNTENRRLFEAEAQDLFQDIQSLPQKAAVRKLNDLIKRARLAKVHAYIISYLKKEMPSMFGKENKKKELISRLPEIYSQLQREYHISAGDFPEVRKMQEQLELCDFTKFHSLKPKLIEAVDNMLANKIASLMSLITQEESNMPTEMVHGGAFDGTMAGPFGQGYGEGAKEGADEDEWVVAKDKPAYDEIFYTLSPINGKISGINAKKEMVTSKLPNSVLGFQGRPVFEFLPPVASKSDTANALEPCDPMPVGISSCSEGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TWQ9</accession>
    <name>A0A8C2TWQ9_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cathepsin D-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC107310248</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_032299403.1">
        <property type="nucleotide sequence ID" value="XM_032443512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TWQ9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005027362.1">
        <property type="protein sequence ID" value="ENSCJPP00005019783.1"/>
        <property type="gene ID" value="ENSCJPG00005016009.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107310248"/>
    <dbReference type="KEGG" id="cjo:107310248"/>
    <dbReference type="GeneTree" id="ENSGT00940000164590"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000006">
        <property type="entry name" value="Cathepsin E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000004">
        <property type="entry name" value="Pepsin A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012848">
        <property type="entry name" value="Aspartic_peptidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF37">
        <property type="entry name" value="CATHEPSIN E-A-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07966">
        <property type="entry name" value="A1_Propeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="2 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034250324" evidence="6">
        <location>
            <begin position="17"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="7">
        <location>
            <begin position="81"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="112"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="275"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="318"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005019783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="405" mass="45287" checksum="0CB0EF4A57BB929F" modified="2022-01-19" version="1">MRAILLTVVYIPFTVALHRVPLVRFKSVNTQLKEKGELEEFWRNHHPAIFARRHLYCFPPDLTLAAGTVSERLYDYMNAQYYGVISVGTPPQSFTVVFDTGSSNFWVPSFYCISEACRVHQRFKSFLSDSYEHGGEPFSLQYGTGQLLGIAAKDTLQISNISIKGQDFGESVFEPGLTFALAHFDGVLGLGYPSLAVGNALPVFDSIMNQKLVEEPVFSFYLKRGDYTENGGVLILGGIDHSLYKGSIHWVPVTEKSYWQIHLNNIKVQGRVAFCSHGCEAIVDSGTSLITGPSSQIRRLQAYIGASPSRSGEFLVDCRRLSSLPHISFTIGHHEYKLTSEQYVVKESIDDQTFCMSGFQSLDIPTRNGPLWILGDVFMSAFYCIFDRGNDRVGFAKSAHSDDYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TXU2</accession>
    <name>A0A8C2TXU2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC107312697</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TXU2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005028005.1">
        <property type="protein sequence ID" value="ENSCJPP00005020312.1"/>
        <property type="gene ID" value="ENSCJPG00005016378.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163390"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022605">
        <property type="term" value="P:mammalian oogenesis stage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045747">
        <property type="term" value="P:positive regulation of Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031398">
        <property type="term" value="P:positive regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004240">
        <property type="entry name" value="EMP70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766:SF176">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034841917" description="Transmembrane 9 superfamily member" evidence="7">
        <location>
            <begin position="18"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="350"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="380"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="417"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="453"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="507"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="536"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="576"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="607"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005020312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="682" mass="78335" checksum="87DEBF4137CD1A59" modified="2022-01-19" version="1">MRLLPAGFLLLLPLCAAFYLPGLAPVSFCDDDKESEGCKSLIELFVNRLDSVESVLPYEYDAFDFCQDKEEKRPSENLGQVLFGERIASSPYKFTFKKQEKCKKVCTRSYDPENSADKSKLAFLKKGMQLNYQHHWIIDNMPVTWCYDVEDGQKFCNPGFPIGCFVTPDGRVKDACVINSEFNKKNTFYLFNHVDITIMYHSGKDENWPGARLVMARLRPQSYKHTDENNLSCEGPPMEIPGEFTNKLNLIYTYSVTFEEKNNIKWASRWDYILESMPHTNIQWFSIMNSLVIVLFLSGMVAMIILRTLHKDIARYNQIDSSEDAQEEFGWKLVHGDVFRPPRKGMLLSVFLGQGTQIFIMTFITLFLACLGFLSPANRGALMTCAVVLWVLLGTPAGYVSARMYKTFRGEKWKTNVLLTALLCPGIVFADFFIMNLILWVKGSSAAIPFGTLVAILAMWFGISVPLTFIGAYFGFKEKPIEHPVRTNQIPRQIPEQSFFTKPLPGIIMGGILPFGCIFIQLFFILNSIWSHQMYYMFGFLFLVFIILLITCSEATVLLCYFHLCAEDYHWWWRSFLTSSFTAVYLFIYAVHYFFSKLQITGTASTILYFGYTMIMVLIFFLFTGTIGFFACFWFVLVALLPHIDKYRHLLIVFTVMDSEDEGKQLPCQTLVVITIQIQQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TZ27</accession>
    <name>A0A8C2TZ27_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">SRY-box transcription factor 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">SOX3</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TZ27"/>
    <dbReference type="Ensembl" id="ENSCJPT00005028903.1">
        <property type="protein sequence ID" value="ENSCJPP00005021004.1"/>
        <property type="gene ID" value="ENSCJPG00005016837.1"/>
    </dbReference>
    <dbReference type="KEGG" id="cjo:107312850"/>
    <dbReference type="GeneTree" id="ENSGT00940000162359"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007530">
        <property type="term" value="P:sex determination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01388">
        <property type="entry name" value="HMG-box_SoxB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000002">
        <property type="entry name" value="transcription factor Sox-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022097">
        <property type="entry name" value="SOX_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050140">
        <property type="entry name" value="SRY-related_HMG-box_TF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270">
        <property type="entry name" value="SOX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270:SF231">
        <property type="entry name" value="TRANSCRIPTION FACTOR SOX-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12336">
        <property type="entry name" value="SOXp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HMG box" evidence="9">
        <location>
            <begin position="48"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="7">
        <location>
            <begin position="48"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="28"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005021004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="316" mass="34029" checksum="E28C742F691AA79C" modified="2022-01-19" version="1">MYSMLETEIKTPQPTPGSAGGNPAPGSNGKGGGGAGSGAGAGSDQDRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKLLSEAEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLLKKDKYSLPGNLLAPGGGNAVSSPVGVGQRIDTYAHMNGWTNGAYSLMQDQLGYGQHPGMNSPQLQPMHRYDMPGLQYSPMMSTAQTYMNAASTYSMSPAAYGQQPSTAMSLGSMGSVVKSEPSSPPPAITSHSQRACLGDLRDMISMYLPPGGDATDPSALQGSRLHSVHQHYQSAGTAVNGTVPLTHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U0Z6</accession>
    <name>A0A8C2U0Z6_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Neuroendocrine protein 7B2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">SCG5</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 7B2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2U0Z6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005028489.1">
        <property type="protein sequence ID" value="ENSCJPP00005020650.1"/>
        <property type="gene ID" value="ENSCJPG00005016603.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000009816"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030141">
        <property type="term" value="C:secretory granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007218">
        <property type="term" value="P:neuropeptide signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046883">
        <property type="term" value="P:regulation of hormone secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007945">
        <property type="entry name" value="Secretogranin_V"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12738">
        <property type="entry name" value="NEUROENDOCRINE PROTEIN 7B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12738:SF0">
        <property type="entry name" value="NEUROENDOCRINE PROTEIN 7B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05281">
        <property type="entry name" value="Secretogranin_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 10" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0765">Sulfation</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034129325" description="Neuroendocrine protein 7B2" evidence="10">
        <location>
            <begin position="19"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005020650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="359" mass="40469" checksum="CEE625A12F1ABCD3" modified="2022-01-19" version="1">MKVVLLFPVLWFFRQCKCTAWEAFPILRRLYIEPRGLQNSITNMWGRGNQFSLNEAVDPFCLQWLLNEHSRETQSRTQIWATHSFVLLCFVFLKGRSSLLFPSGPQRPSSDSRSWRLQLAARMASTMLRTTTFLLLFGLASAYSHSARTPDRVSEADIQRLLHGVMEQLGIARPRVEYPAHQAMNLVGPQSIEGGAHEGLQHLGPYGNIPNIVAELTGDNIPKDFSEDQGYPDPPNPCPIGKTVDDGCLENTPDTAEFSREYQLHQHLFDPEHNYPNTGKWVSTCLLVGLPHVALGFVAWDTQSHREHNGLIAGRTVTLKGASQKDEPALKNAEIEARKKRINEKPMEAENRNTSLIMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U1F4</accession>
    <name>A0A8C2U1F4_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MID1 interacting protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MID1IP1</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SPOT14 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015740114.1">
        <property type="nucleotide sequence ID" value="XM_015884628.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U1F4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005028886.1">
        <property type="protein sequence ID" value="ENSCJPP00005020990.1"/>
        <property type="gene ID" value="ENSCJPG00005016826.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107324529"/>
    <dbReference type="KEGG" id="cjo:107324529"/>
    <dbReference type="CTD" id="58526"/>
    <dbReference type="GeneTree" id="ENSGT00500000044890"/>
    <dbReference type="OrthoDB" id="5951908at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046890">
        <property type="term" value="P:regulation of lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053719">
        <property type="entry name" value="Lipogen_MT_Stabilize_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009786">
        <property type="entry name" value="Spot_14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14315:SF16">
        <property type="entry name" value="MID1-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14315">
        <property type="entry name" value="SPOT14 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07084">
        <property type="entry name" value="Spot_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005020990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="239" mass="25976" checksum="95520A2918E8FC5A" modified="2022-01-19" version="1">MSGRGERRLHAGPACPRRPPVSQSVTQPAGRTLSELRYKYGAGDGGGCGRLRSASIPGALEERSGVLRRAGRPAASPGGRMQICESYSQKYSLFNAMNRFIGAVNNMDQTVMVPSLLRDVPLLLGELDAAGAVCPEREAAPGGGYFSRRDMYSHYVLLKSIRNDIEWGVVQQAAGEEAARKKDKLGGGPAEEAEAEEDLEQQFHYHLSGLHSVLSKLTRKANVLTNRYKQEIGFGSWGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U490</accession>
    <name>A0A8C2U490_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">3-dehydrosphinganine reductase</fullName>
            <ecNumber evidence="10">1.1.1.102</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">KDSR</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the reduction of 3'-oxosphinganine (3-ketodihydrosphingosine/KDS) to sphinganine (dihydrosphingosine/DHS), the second step of de novo sphingolipid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>sphinganine + NADP(+) = 3-oxosphinganine + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22640"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57817"/>
            <dbReference type="ChEBI" id="CHEBI:58299"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.102"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:22642"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.102" evidence="10"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2U490"/>
    <dbReference type="Ensembl" id="ENSCJPT00005028780.1">
        <property type="protein sequence ID" value="ENSCJPP00005020919.1"/>
        <property type="gene ID" value="ENSCJPG00005016774.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156961"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047560">
        <property type="term" value="F:3-dehydrosphinganine reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006666">
        <property type="term" value="P:3-keto-sphinganine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd08939">
        <property type="entry name" value="KDSR-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000165">
        <property type="entry name" value="3-ketodihydrosphingosine reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045022">
        <property type="entry name" value="KDSR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43550">
        <property type="entry name" value="3-KETODIHYDROSPHINGOSINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43550:SF3">
        <property type="entry name" value="3-KETODIHYDROSPHINGOSINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0746">Sphingolipid metabolism</keyword>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="62"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00026112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005020919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="300" mass="32607" checksum="8D1CEC3E80AE5F1A" modified="2022-01-19" version="1">MLLLAAAFIVAIVLLLYMVSPLISPKPLKLPGAHVVVTGGSSGIGKCIAIECYKQGAFITLIARDENKLLQTKKEIEKYSVNDKQVVLCISVDVSKDYEQVENVLKQAQEKLGPVDLLVNCAGTSVTGKFEDIEVNSFERLMAVNYLGSVYPSRAVISTMKERRMGRIVFVSSQAGQLGLFGYTAYSPTKFALRGLAEALQMEVKPYNIYITVAYPPDTDTPGFAEESKTKPLETKLISETSSVCQAEQVARVIVKDAIQGNFNSFVGSDGYMLSILTSGMSPVTSITEGLQQVRLAKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U5F3</accession>
    <name>A0A8C2U5F3_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosome binding factor A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">RBFA</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U5F3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005030979.1">
        <property type="protein sequence ID" value="ENSCJPP00005022595.1"/>
        <property type="gene ID" value="ENSCJPG00005017999.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000011362"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000238">
        <property type="entry name" value="RbfA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023799">
        <property type="entry name" value="RbfA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039212">
        <property type="entry name" value="RBFA_mitochondrial"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14725">
        <property type="entry name" value="RIBOSOME-BINDING FACTOR A, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14725:SF0">
        <property type="entry name" value="RIBOSOME-BINDING FACTOR A, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02033">
        <property type="entry name" value="RBFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89919">
        <property type="entry name" value="Ribosome-binding factor A, RbfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="191"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005022595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="312" mass="35532" checksum="0C4F16CC8FE32DAF" modified="2022-01-19" version="1">MWGARMAANAAPLCCRALRSSAVLGGSRNLLKKMLHKKKYVLWRLMYEPTKLATTKQADQTKTRREDTIRCRVLNGLIHKAVTEMISSCEINKELYDLKLEICKVSLASNFSACRIYWNPASTTDSDNYVEGVLRKSAPRIRYLLMSQQILGNVPPVVFVKDKEAAAVKEIEELLAIADFGPQEEEIPQNDSSESPDTQSSDSPVRSNLFGVDHELLNKQIMEYKKLKLSRITESVPWTQSQGQQLSKIQKKMKKKKTKNIPDDDITPQKYLLDRYEADYFDDNNESISDYELDDELQEVNELEANGGKTQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U6C2</accession>
    <name>A0A8C2U6C2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">V-set and transmembrane domain-containing protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">VSTM4</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Peptide Lv enhances L-type voltage-gated calcium channel (L-VGCC) currents in retinal photoreceptors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015722262.1">
        <property type="nucleotide sequence ID" value="XM_015866776.2"/>
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        <property type="protein sequence ID" value="ENSCJPP00005023910.1"/>
        <property type="gene ID" value="ENSCJPG00005018887.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107315878"/>
    <dbReference type="KEGG" id="cjo:107315878"/>
    <dbReference type="CTD" id="196740"/>
    <dbReference type="GeneTree" id="ENSGT00390000008566"/>
    <dbReference type="OrthoDB" id="8885867at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 6"/>
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        <property type="term" value="C:extracellular region"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="P:endothelial cell migration"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:endothelial cell proliferation"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:retina blood vessel maintenance"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:retina vasculature development in camera-type eye"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:sprouting angiogenesis"/>
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        <property type="term" value="P:vasodilation"/>
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        <property type="entry name" value="V-set and transmembrane domain containing 4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
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        <property type="entry name" value="Ig-like_dom_sf"/>
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        <property type="entry name" value="Ig-like_fold"/>
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        <property type="entry name" value="Ig_sub"/>
    </dbReference>
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        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051102">
        <property type="entry name" value="IgSF_V-set/TM_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12207">
        <property type="entry name" value="V-SET AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12207:SF8">
        <property type="entry name" value="V-SET AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="8 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 16" id="KW-0732">Signal</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034911474" description="V-set and transmembrane domain-containing protein 4" evidence="16">
        <location>
            <begin position="24"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="17">
        <location>
            <begin position="18"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="222"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="222"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
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            <dbReference type="ARBA" id="ARBA00004613"/>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50835"/>
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        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005023910.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="318" mass="35980" checksum="7B3CA7777C7E1364" modified="2022-01-19" version="1">MRLLATALAALLASAPAPDVCEALNVTVSPGPTVRYSEGDNATLYCHISQKRKMDNLLAVRWVFAVSPTQEYLMIKMTKFGSVQYYGNYTHNFHKQRLRLLKEKHGTLYKFLILSLQQTDQGHYICKVQEIGKHRNKWTAWSNGTAATEIRVISSKASDDPTYKKKHEAWKFFEDLYVYAVFVCSIGIISVLLFTLVILCQSLLNKRRCAVKHYLVKCPQNSSGETVTSVTSMSPLQPKKGKKRKEKAELPPAIPEKAPIANIPKPKLLKPQRKLILPKIAEENLTYAELELMKPIQEAKGIPSTTVYAQILFEENKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U6U0</accession>
    <name>A0A8C2U6U0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">PPP2R2C</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
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            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the phosphatase 2A regulatory subunit B family.</text>
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    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B"/>
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    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
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    </dbReference>
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        <property type="entry name" value="PP2A_PR55"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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            <dbReference type="ARBA" id="ARBA00022574"/>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005023356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="428" mass="49458" checksum="3E9186601DCB6B62" modified="2022-01-19" version="1">GAFYTDIISTVEFNHTGELLATGDKGGRVVIFQREPESKNEPYSQGEYNVYSTFQSHEPEFDYLKSLEIEEKINKIKWLPQQNAAHSLLSTNDKTIKLWKISERDKRPEGYNLKDEDGKLKDLSTVTSLQVPVLKPMDLMVEVTPRRIFANGHTYHVNSISVNSDCETYMSADDLRINLWHLEITDRSFNIVDIKPANMEDLTEVITASEFHPHHCNIFVYSSSKGTIRLCDMRTSALCDKHSKLYEEPEDPSNRSFFSEIISSVSDVKFSHSGRYMLTRDYLTVKVWDLNMETKPVETYQVHDYLRSKLCSLYENDCIFDKFECAWNGSDSVIMTGSYNNFFRMFDRNTKRDVTLEASRESSKPRAILKPRKVCVGGKRRKDEISVDSLDFNKKILHTAWHPTENIIAVAATNNLYIFQDKVNSEMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U6W4</accession>
    <name>A0A8C2U6W4_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">A-kinase anchoring protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">AKAP1</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015736588.1">
        <property type="nucleotide sequence ID" value="XM_015881102.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015736589.1">
        <property type="nucleotide sequence ID" value="XM_015881103.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U6W4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005032240.1">
        <property type="protein sequence ID" value="ENSCJPP00005023541.1"/>
        <property type="gene ID" value="ENSCJPG00005018648.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107322744"/>
    <dbReference type="KEGG" id="cjo:107322744"/>
    <dbReference type="CTD" id="8165"/>
    <dbReference type="GeneTree" id="ENSGT00390000001360"/>
    <dbReference type="OrthoDB" id="10069557at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034237">
        <property type="term" value="F:protein kinase A regulatory subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140374">
        <property type="term" value="P:antiviral innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd22395">
        <property type="entry name" value="KH-I_AKAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20407">
        <property type="entry name" value="Tudor_AKAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047368">
        <property type="entry name" value="KH-I_AKAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
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    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047367">
        <property type="entry name" value="Tudor_AKAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050621">
        <property type="entry name" value="Tudor_domain_containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22948:SF65">
        <property type="entry name" value="A-KINASE ANCHORING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22948">
        <property type="entry name" value="TUDOR DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00567">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="4">
        <location>
            <begin position="740"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="49"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="418"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="487"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="429"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="487"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="509"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="530"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005023541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="882" mass="95411" checksum="ECF9721E67CFF878" modified="2022-01-19" version="1">MALRFRTFIPYAIPGVLALLGCWWIYSHRKKHPSNHKRKAIAIVEEKQKELPENDSPPKTEACVPQRLPLSPEEERPENETSTSLLPAGPMTPSLTRQTRERLDFSRDLSAPAIRTTQPSTIEDDSEKLEIKDSQDENSVPACVSLPLISKSAKCHSGAAVSPEEDSGSSANQAKCPSASVVLTQGPFGIAEEISNAEQSDESSFKSPKESQMPEIALSDTGCVTALHLGLEKEANTPQALLTNEVVLSHQDSAVRMLPDSLQSACLEQCREEKISESNDSTVPVCHGEDTHAKGNELERGRIRGVSLDKEEVEKIEQVAIQIISNVILAATEEVLSGSVSDVSSRICQAAASRVERPQERASTVSSDELLVAEAGGGDKNTALKSDAAVPTSLPTEECDQCVTYSSCSALGHLSSPVQRDAQDHQEKNCVSSESQGGDRTLVASHGESLGKSHLTVEDSGFSTCASEGGTSVEDLLQNTMLSVASGQHSDSLSTSATQDTSAEQSSEAGEKPTTKLPEDSKVPYSNGMLKEDGSESRHESNWVAETDGDHSGGSDVNSMDSVDSGCALGKTETHQNSKPGGESSKSDLTIWEIEVPKHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYSHDFQICHIEGSQHHVEKALSLIGKKFKELSLTNVYAPPPPSLALHSLPITSWLMLPDGVTVEVVVANQVNAGHMFLQQHTHPTFHVLRSLDQQMYVCYSQPGIPTLPTPVEVGIICAAPGLDGAWWRAQVVGYFKDSGEVEIRYVDYGGYERVKIDTLRQIRSDFVTLPFQGAEVLLDNVVPLPDEDHFSSEADAAVSEMTRGAALLAQVTNYDSATGLPLIQLWSMMGDEVVSINRTLVERGFAQWVDNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U706</accession>
    <name>A0A8C2U706_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">heme oxygenase (biliverdin-producing)</fullName>
            <ecNumber evidence="3">1.14.14.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">HMOX1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the heme oxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.18" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2U706"/>
    <dbReference type="Ensembl" id="ENSCJPT00005031337.1">
        <property type="protein sequence ID" value="ENSCJPP00005022865.1"/>
        <property type="gene ID" value="ENSCJPG00005018177.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000017673"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004392">
        <property type="term" value="F:heme oxygenase (decyclizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071243">
        <property type="term" value="P:cellular response to arsenic-containing substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071276">
        <property type="term" value="P:cellular response to cadmium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072719">
        <property type="term" value="P:cellular response to cisplatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904019">
        <property type="term" value="P:epithelial cell apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030218">
        <property type="term" value="P:erythrocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042167">
        <property type="term" value="P:heme catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006788">
        <property type="term" value="P:heme oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060586">
        <property type="term" value="P:multicellular organismal-level iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900016">
        <property type="term" value="P:negative regulation of cytokine production involved in inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902042">
        <property type="term" value="P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110076">
        <property type="term" value="P:negative regulation of ferroptosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016242">
        <property type="term" value="P:negative regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048662">
        <property type="term" value="P:negative regulation of smooth muscle cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045766">
        <property type="term" value="P:positive regulation of angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903589">
        <property type="term" value="P:positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090050">
        <property type="term" value="P:positive regulation of cell migration involved in sprouting angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904037">
        <property type="term" value="P:positive regulation of epithelial cell apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016239">
        <property type="term" value="P:positive regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048661">
        <property type="term" value="P:positive regulation of smooth muscle cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035094">
        <property type="term" value="P:response to nicotine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002246">
        <property type="term" value="P:wound healing involved in inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd19165">
        <property type="entry name" value="HemeO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.910.10:FF:000001">
        <property type="entry name" value="Heme oxygenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002051">
        <property type="entry name" value="Haem_Oase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016053">
        <property type="entry name" value="Haem_Oase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018207">
        <property type="entry name" value="Haem_oxygenase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10720">
        <property type="entry name" value="HEME OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10720:SF1">
        <property type="entry name" value="HEME OXYGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01126">
        <property type="entry name" value="Heme_oxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00088">
        <property type="entry name" value="HAEMOXYGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00593">
        <property type="entry name" value="HEME_OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="231"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="238"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005022865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="317" mass="35804" checksum="B6587A805344259D" modified="2022-01-19" version="1">METSQPHGAESMSQDLSELLKEATKEVHEQAENTPFMKNFQKGQVSLHEFKLVTASLYFIYSALEEEIERNKDNPVYAPVYFPTELHRKDALEKDLEYFYGSNWRAEIPCPEATQKYVERLHYVGKKNPELLVAHAYTRYLGDLSGGQVLKKIAQKALQLPSTGEGLAFFTFDGVSNATKFKQLYRSRMNALEMDHATKKRVLEEAKKAFLLNIQVFEALQKLVSNSQENGHAVQPKAEVRARNVNKSHENGLAAAKESERTRRMQADMLTTSPLVRWILALGFIATTVAVGLFAIKQSAARGSRPFPCLLQALLTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U948</accession>
    <name>A0A8C2U948_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Claudin 34</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">CLDN34</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Tight junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the claudin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2U948"/>
    <dbReference type="Ensembl" id="ENSCJPT00005031426.1">
        <property type="protein sequence ID" value="ENSCJPP00005022935.1"/>
        <property type="gene ID" value="ENSCJPG00005018218.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000005717"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006187">
        <property type="entry name" value="Claudin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004031">
        <property type="entry name" value="PMP22/EMP/MP20/Claudin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12002">
        <property type="entry name" value="CLAUDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13903">
        <property type="entry name" value="Claudin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01077">
        <property type="entry name" value="CLAUDIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0965">Cell junction</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0796">Tight junction</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005022935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="229" mass="24667" checksum="6173813A4BEC6C32" modified="2022-01-19" version="1">MSSLTGTSHLQLASFVLGMIGWILCTISMGLVDWRVWHVDNTTIISSGIAWVGIWKVCFISYIHVSPGYEEQFCHKFSGYDSSIPGEIYAAQGLLVIAMVTGLLALTATIYALRNIYMGISRKTPITRFFLVGGFFYIFAGLCVLIPVSHNFYSVTHNQTIAFPPSYLMPSSPVAQEAGAAIPIGIIAAILLLLSGTICILCCNTSASGQGALLVPHLCMAKKSATYVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UAT7</accession>
    <name>A0A8C2UAT7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Leukocyte cell-derived chemotaxin 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Chondromodulin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">CNMD</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Endomembrane system</location>
            <topology evidence="14">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chondromodulin-1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015707477.1">
        <property type="nucleotide sequence ID" value="XM_015851991.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UAT7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005034075.1">
        <property type="protein sequence ID" value="ENSCJPP00005025017.1"/>
        <property type="gene ID" value="ENSCJPG00005019681.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107308233"/>
    <dbReference type="KEGG" id="cjo:107308233"/>
    <dbReference type="CTD" id="11061"/>
    <dbReference type="GeneTree" id="ENSGT00480000042679"/>
    <dbReference type="OrthoDB" id="5985282at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051216">
        <property type="term" value="P:cartilage development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016525">
        <property type="term" value="P:negative regulation of angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001937">
        <property type="term" value="P:negative regulation of endothelial cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.150:FF:000001">
        <property type="entry name" value="leukocyte cell-derived chemotaxin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007084">
        <property type="entry name" value="BRICHOS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043405">
        <property type="entry name" value="Chondromodulin/Tenomodulin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14064">
        <property type="entry name" value="CHONDROMODULIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14064:SF6">
        <property type="entry name" value="LEUKOCYTE CELL-DERIVED CHEMOTAXIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04089">
        <property type="entry name" value="BRICHOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01039">
        <property type="entry name" value="BRICHOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50869">
        <property type="entry name" value="BRICHOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0891">Chondrogenesis</keyword>
    <keyword evidence="6" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-0221">Differentiation</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="BRICHOS" evidence="19">
        <location>
            <begin position="103"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="208"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="236"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00039682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00042622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005025017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="343" mass="38085" checksum="79B67B96079D2565" modified="2022-01-19" version="1">MAEGSEKVPIARAGPEDVEQGLPPAYTAAVPPPGPGRLLKAGATVLIAGALLLLAGAIGAFYFWKATERQVYNVHYTMSINGKVQDGSMEIDAGNNLETFKTGSGSEEAVEVHDFQIGITGIRFAGGEKCYIKAQPKARVPEVDAMTKASLSSDLEDEIMPVRFDENSLIWVAADEPIKHNGFLSPKILELCGDLPIFWLRPTYPKDKQRERREMKRNKRQSESNFDAAAAEEVNTRSTPTRLTQELGPQSNETGPMQQESDQTLNPDNPYNQLEGEGMAFDPMLDHLGVCCIECRRSYTQCQRICEPLLGYYPWPYNYQGCRTACRIIMPCSWWVARIMGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UAU1</accession>
    <name>A0A8C2UAU1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">HIPK2</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. HIPK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2UAU1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005035244.1">
        <property type="protein sequence ID" value="ENSCJPP00005025970.1"/>
        <property type="gene ID" value="ENSCJPG00005020296.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157742"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016605">
        <property type="term" value="C:PML body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061629">
        <property type="term" value="F:RNA polymerase II-specific DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046332">
        <property type="term" value="F:SMAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046790">
        <property type="term" value="F:virion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007628">
        <property type="term" value="P:adult walking behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009952">
        <property type="term" value="P:anterior/posterior pattern specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008283">
        <property type="term" value="P:cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030330">
        <property type="term" value="P:DNA damage response, signal transduction by p53 class mediator"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048596">
        <property type="term" value="P:embryonic camera-type eye morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060059">
        <property type="term" value="P:embryonic retina morphogenesis in camera-type eye"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042771">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061072">
        <property type="term" value="P:iris morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060235">
        <property type="term" value="P:lens induction in camera-type eye"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060425">
        <property type="term" value="P:lung morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030514">
        <property type="term" value="P:negative regulation of BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043524">
        <property type="term" value="P:negative regulation of neuron apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000059">
        <property type="term" value="P:negative regulation of ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051402">
        <property type="term" value="P:neuron apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045766">
        <property type="term" value="P:positive regulation of angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046330">
        <property type="term" value="P:positive regulation of JNK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030511">
        <property type="term" value="P:positive regulation of transforming growth factor beta receptor signaling pathway"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003016">
        <property type="term" value="P:respiratory system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010842">
        <property type="term" value="P:retina layer formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060395">
        <property type="term" value="P:SMAD protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007224">
        <property type="term" value="P:smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030878">
        <property type="term" value="P:thyroid gland development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007179">
        <property type="term" value="P:transforming growth factor beta receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050882">
        <property type="term" value="P:voluntary musculoskeletal movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd14227">
        <property type="entry name" value="STKc_HIPK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000029">
        <property type="entry name" value="Homeodomain-interacting protein kinase 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000022">
        <property type="entry name" value="Homeodomain-interacting protein kinase 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF53">
        <property type="entry name" value="HOMEODOMAIN-INTERACTING PROTEIN KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="212"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="781"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="851"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="975"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="781"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="806"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="909"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="927"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="975"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="1019"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00061380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005025970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1183" mass="129447" checksum="84839BEEFDAB721B" modified="2022-01-19" version="1">MQDWSNCRMPAWAFCMASHVQVFSPHTLQSSAFCSVKKLKVEPSSNWDMTGYGTHSKVYSQSKSVQSSQAAAAAAVNASLQIPNPSIPYEQTIIFPASTGHIVVTSANSTSGVVAVSGQTLGGPHNLMRRSTVSLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESADDYNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMTHLLDFPHSTHVKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAPSTSTNLTMTFNNQLNTVHNQPSAASMAAVAQRSMPLQTGTAQICARPDPFQQALIVCPPGFQGLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQQAWPSGTQQILLPPAWQQLTGVATHTSVQHATVIPESMAGTQPLADWRNTHAHGSHYNPIMQQPALLASHVTLPAAQPVNVGVAHVMRQPPATTTSTRKSKQHQSAPRNASTYEVSSSQSISSPQRSKRVKENTPPRCAMVHNSPACSTAVTCGWGDVATSTTRERQRQPIIIPDTPSPAVSVITISSDTDEEEEQKHAPTSTLSKQRKNVISCVTVHDSPYSDSSSNNSPYATQHRAGQNNGNTYDTKGVPETHCSGNPRTIIVPPLKTQASEVLVECDSLAPVTTSHHSSSYKSKSSSTVTSTSGHSSGSSSGAVAYRQQRPGAHFQQQQPLNLSQAQQHITTDRTGSHRRQQAYITPTIAQAPYSFPHNSPSHGTVHPHLAAAAAAHLPTQPHLYTYTTPAALGSTGTVAHLVASQGSARHAVQHTTYPASIVHQVPVSMGPRVLPSPTIHPSQYQAQFAHQTYISASPASTVYTGYPLSPTKVNQYPYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UB36</accession>
    <name>A0A8C2UB36_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ETS variant transcription factor 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ETV4</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ETS family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015741411.1">
        <property type="nucleotide sequence ID" value="XM_015885925.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UB36"/>
    <dbReference type="Ensembl" id="ENSCJPT00005033445.1">
        <property type="protein sequence ID" value="ENSCJPP00005024559.1"/>
        <property type="gene ID" value="ENSCJPG00005019343.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107325251"/>
    <dbReference type="KEGG" id="cjo:107325251"/>
    <dbReference type="CTD" id="2118"/>
    <dbReference type="GeneTree" id="ENSGT00940000158142"/>
    <dbReference type="OrthoDB" id="10067219at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045618">
        <property type="term" value="P:positive regulation of keratinocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000121">
        <property type="entry name" value="ETS translocation variant 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000418">
        <property type="entry name" value="Ets_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046328">
        <property type="entry name" value="ETS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006715">
        <property type="entry name" value="ETS_PEA3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849:SF181">
        <property type="entry name" value="ETS TRANSLOCATION VARIANT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00178">
        <property type="entry name" value="Ets"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04621">
        <property type="entry name" value="ETS_PEA3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00454">
        <property type="entry name" value="ETSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00413">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00345">
        <property type="entry name" value="ETS_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00346">
        <property type="entry name" value="ETS_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50061">
        <property type="entry name" value="ETS_DOMAIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETS" evidence="8">
        <location>
            <begin position="300"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="95"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005024559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="442" mass="49895" checksum="38B6A7CE317B4F55" modified="2022-01-19" version="1">MKGYVDQQVPFTFPQPPPGHAGSGCRTPGAGKSPMEPGLLPAQDSEELFQDLSQFQETWLTEAQVPDSDEQFVPDFHSENLAFHSPPAKIKKEPQSPSSDPTLSCNHKQPFQYRNGEQCLYASAYDQPRPVGIKSPDPGTPIQSPLQQFPRQDRNFLTPSGPPHPTSSCGYLIENSSAYQPPVEMCHSFPSSQGMARDAPIAYQRPISEQCLQFPPQGFKQEFHDPLYEQASSSCQYPAAVVIKQEQVDYMYDSGCSYDKQMRPFADDVCVVPEKFEAGDIKQEVGGYREGPPYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVARLWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCEPEALFSLAFPDNQRPALKAELERQISEEDTVPLSHLDEGTAYLPDLGSLPPQLYSKGYTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UCY4</accession>
    <name>A0A8C2UCY4_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation factor-like GTPase 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Elongation factor Tu GTP-binding domain-containing protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Elongation factor-like 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Protein FAM42A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">EFL1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">GTPase involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes. Together with SBDS, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <dbReference type="RefSeq" id="XP_015728477.1">
        <property type="nucleotide sequence ID" value="XM_015872991.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032302651.1">
        <property type="nucleotide sequence ID" value="XM_032446760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UCY4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005035186.1">
        <property type="protein sequence ID" value="ENSCJPP00005025921.1"/>
        <property type="gene ID" value="ENSCJPG00005020256.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107318767"/>
    <dbReference type="KEGG" id="cjo:107318767"/>
    <dbReference type="CTD" id="79631"/>
    <dbReference type="GeneTree" id="ENSGT00550000074806"/>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046039">
        <property type="term" value="P:GTP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01681">
        <property type="entry name" value="aeEF2_snRNP_like_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04096">
        <property type="entry name" value="eEF2_snRNP_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01885">
        <property type="entry name" value="EF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16268">
        <property type="entry name" value="EF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16261">
        <property type="entry name" value="EF2_snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000006">
        <property type="entry name" value="Elongation factor like GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000732">
        <property type="entry name" value="Elongation factor like GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1430.10:FF:000002">
        <property type="entry name" value="Elongation factor like GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000066">
        <property type="entry name" value="Elongation factor Tu GTP-binding domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000044">
        <property type="entry name" value="elongation factor-like GTPase 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1430.10">
        <property type="entry name" value="Yeast translation eEF2 (G' domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056752">
        <property type="entry name" value="EFL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF3">
        <property type="entry name" value="ELONGATION FACTOR-LIKE GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25118">
        <property type="entry name" value="EFL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Tr-type G" evidence="15">
        <location>
            <begin position="17"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="443"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="911"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="443"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="911"/>
            <end position="927"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00077934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00080041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00081809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005025921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1139" mass="126670" checksum="7E433D107AAF7F0F" modified="2022-01-19" version="1">MVLTSVGKMMGLQQKAAGIRNICVLAHVDHGKTTLADCLISSNGIISSRLAGKLRYMDSREDEQVRGITMKSSAISLHFQKGGQEYLINLIDSPGHVDFSSEVSTAVRLCDGCIIVVDAVEGVCPQTQAVLRQAWLENIRPVLVINKIDRLIVELKLTPQEAYMHLKNILEQINAVTGSLFTSKVLEERAEKEAENESSSDTAAGDQIYDWSAGLEDTDDSHLYFSPDHGNVVFASAIDGWGFGIEHFAKLYSQKIGIKPALLLKTLWGDYYLNTKAKKIMKGDQSKGKKPLFVQLVLDNIWSLYEAVMKRDKEKIEKIVTSLGLKIGPRESRHADPKVHLNAICSQWLPISDAVLSMVCSKLPSPLDITPERVEKLMCVGAKTFDSLPPETQELKSAFLKCSSEGTAPVIVFVSKMFAVDAKALPHNKPRPLTQEEIAQRRELAKQRHAEKVAASQGKEVPEKPPSENSSEGSGNSGDKKGEEQQLTDQMDLVTSKAAKQEADNKESFIAFARVFSGVVRRGQKIFVLGPKYDPAESLHKLSSQCSATDDLPLVPHMSCCTLENLYLLMGRELEELEEVPAGNVLGIGGLQDFVLKSATLSTSPACPPFTPLNFEATPIVRVAVEPKHPSDMPQLVRGMKLLNQADPCVQVLIQETGEHVLVTAGEVHLQRCLDDLKERFAKIEISVSAPIIPFRETITRPPKVDMVNEEIGKQQKVAVIHQTKEDQSKIPEGIQVDSDGLVTISTPNKQATLSVRALPLPEEVTRLLEENSDLIRTMEQLSTSLNEDKNTHEINQKTMDKIKEFKQKLEQNLQGRKWRNAVDHIWSFGPRKCGPNILLHKFEGYKNSVWQCLENAEKEVSKYGDFDNSIVSGFQLATLSGPMCEEPLMGVCFAVEKWEMNKVGEMLPTKSRDSGECDAVEHKESEEAVSPTSTCTADICSENEHEQSSQTVPKSLEKNSKNKGEVSLMDCYGPFSGQLIATMKEACRYALQAKPQRLMAAMYTCEIMATAEVLGRVYAVLSKREGRVLQEEMKEGTDVFIIKAVLPVAESFGFADEIRKRTSGLASPQLVFSHWEIISSDPFWVPTTEEEYLHFGEKADSENQARKYMNAVRKRKGLYVEEKIVEHAEKQRTLSRNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UEU2</accession>
    <name>A0A8C2UEU2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L32</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">RPL32</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL32 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015730621.1">
        <property type="nucleotide sequence ID" value="XM_015875135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UEU2"/>
    <dbReference type="SMR" id="A0A8C2UEU2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005036237.1">
        <property type="protein sequence ID" value="ENSCJPP00005026739.1"/>
        <property type="gene ID" value="ENSCJPG00005020793.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107319864"/>
    <dbReference type="KEGG" id="cjo:107319864"/>
    <dbReference type="CTD" id="6161"/>
    <dbReference type="GeneTree" id="ENSGT00940000158890"/>
    <dbReference type="OrthoDB" id="268693at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00513">
        <property type="entry name" value="Ribosomal_L32_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001515">
        <property type="entry name" value="Ribosomal_eL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018263">
        <property type="entry name" value="Ribosomal_eL32_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036351">
        <property type="entry name" value="Ribosomal_eL32_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L32 AND DNA-DIRECTED RNA POLYMERASE II, SUBUNIT N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413:SF1">
        <property type="entry name" value="RIBOSOMAL PROTEIN L32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01655">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01393">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52042">
        <property type="entry name" value="Ribosomal protein L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00580">
        <property type="entry name" value="RIBOSOMAL_L32E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005026739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="135" mass="15916" checksum="77844D227480DF4F" modified="2022-01-19" version="1">MPALRPLVKPKIVKKRTKKFIRHQSDRYVKIKRNWRKPRGIDNRVRRRFKGQILMPNIGYGSNKKTKHMLPTGFRKFLVHNVKELEVLMMSNKSYCAEIAHNVSSKNRKVIVERAAQLAIKITNPNARLRSEENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UFR8</accession>
    <name>A0A8C2UFR8_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mothers against decapentaplegic homolog</fullName>
            <shortName evidence="10">MAD homolog</shortName>
            <shortName evidence="10">Mothers against DPP homolog</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">SMAD family member</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">SMAD3</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the dwarfin/SMAD family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2UFR8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005036561.1">
        <property type="protein sequence ID" value="ENSCJPP00005026987.1"/>
        <property type="gene ID" value="ENSCJPG00005020970.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153499"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071144">
        <property type="term" value="C:heteromeric SMAD protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043425">
        <property type="term" value="F:bHLH transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070410">
        <property type="term" value="F:co-SMAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005518">
        <property type="term" value="F:collagen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017151">
        <property type="term" value="F:DEAD/H-box RNA helicase binding"/>
        <property type="evidence" value="ECO:0007669"/>
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    <name>A0A8C2UGK5_COTJA</name>
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        <recommendedName>
            <fullName evidence="2">SPIN-DOC-like zinc-finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UGK5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005036477.1">
        <property type="protein sequence ID" value="ENSCJPP00005026937.1"/>
        <property type="gene ID" value="ENSCJPG00005020919.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00980000200147"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040647">
        <property type="entry name" value="SPIN-DOC_Znf-C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052675">
        <property type="entry name" value="ZnF_transloc-Spindlin_int"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34589">
        <property type="entry name" value="SIMILAR TO RIKEN CDNA 2700081O15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34589:SF2">
        <property type="entry name" value="ZINC FINGER TRANSLOCATION-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18658">
        <property type="entry name" value="zf-C2H2_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPIN-DOC-like zinc-finger" evidence="2">
        <location>
            <begin position="89"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="318"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005026937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="422" mass="45751" checksum="A8049D6BCA41C6EA" modified="2022-01-19" version="1">REPRGAERSRTLPIPHADKERRGYRTGGRGLTTSHAPLVQRGRGFLRALGGGFGFPDRGGRRSTDHCEARASRPGRSRIPGRDHRRYYHERWRAEYLMEFNAARHGMLCMVCGSALATLKLSTIKRHIRQKHPYSGAWGPREKQLILRSWDANLGPHADPDAILSAGGRGPGTSPLRVAPYSRAVGSLSYKPRPLRNATPTNHLGPAPDGARPHPFPKAPPRGPRPFPGPVSQPPHPPLPPHIPPTSRRRQPPQPSPITNAPSPPSPYLPPQPSRSPSANPTHHGDIPVPHSLMSPPSYPGAPSRLPPPANPVPQPSAPQAIRAPARPPIRASQQPHPPQRPPPSPVFPSPAPPHIPCLPHPPPISTPPPLVVPPHPLPDVPRPMPPAWPPPRIPYLPPLTHPGDRNSSSPPHPPHISPPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UJ01</accession>
    <name>A0A8C2UJ01_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="14">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">SMURF2</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6 14">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Membrane raft</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="14"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2UJ01"/>
    <dbReference type="Ensembl" id="ENSCJPT00005037242.1">
        <property type="protein sequence ID" value="ENSCJPP00005027564.1"/>
        <property type="gene ID" value="ENSCJPG00005021344.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155563"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046332">
        <property type="term" value="F:SMAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030514">
        <property type="term" value="P:negative regulation of BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030512">
        <property type="term" value="P:negative regulation of transforming growth factor beta receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160020">
        <property type="term" value="P:positive regulation of ferroptosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd08382">
        <property type="entry name" value="C2_Smurf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000017">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000026">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000047">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000024">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000014">
        <property type="entry name" value="E3 ubiquitin-protein ligase SMURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000007">
        <property type="entry name" value="E3 ubiquitin-protein ligase SMURF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024928">
        <property type="entry name" value="E3_ub_ligase_SMURF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF300">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SMURF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001569">
        <property type="entry name" value="E3_ub_ligase_SMURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="11 14 16" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="C2" evidence="17">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="18">
        <location>
            <begin position="131"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="18">
        <location>
            <begin position="225"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="18">
        <location>
            <begin position="271"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="19">
        <location>
            <begin position="393"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="15 16">
        <location>
            <position position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR001569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001569-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005027564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="727" mass="83977" checksum="A81ACFA0E689018F" modified="2022-01-19" version="1">KDFFRLPDPFAKVVVDGSGQCHSTDTVKNTLDPKWNQHYDLYIGKSDSITISVWNHKKIHKKQGAGFLGCVRLLSNAINRLKDTGYQRLDLCKLGPNDNDTVRGQIVVSLQSRDRIGTGGQVVDCSRLFDNDLPDGWEERRTASGRIQYLNHITRTTQWERPTRPASEYSSPGRPLSCFVDENTPITGTNGATCGQSSDPRLAERRVRSQRHRNYMSRTHLHTPPDLPEGYEQRTTQQGQVYFLHTQTGVSTWHDPRVPRDLSNINCEELGPLPPGWEIRNTATGRVYFVDHNNRTTQFTDPRLSANLHLVLNRQNQLKDQQHQQQQQVVSLCQLPDEAECLTVPRYKRDLVQKLKILRQELSQQQPQAGHCRIEVSREEIFEESYRQVMKMRPKDLWKRLMIKFRGEEGLDYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAVNPEHLSYFHFVGRIMGMAVFHGHYIDGGFTLPFYKQLLGKPITLDDMELVDPDLHNSLVWILENDITGVLDHTFCVEHNAYGEIIQHELKPNGKSIPVTEENKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIPQHLLKTFDEKELELIICGLGKIDVNDWKANTRLKHCTPDSNIVKWFWKAVEFFDEERRARLLQFVTGSSRVPLQGFKALQGAAGPRLFTIHQIDASTNNLPKAHTCFNRIDIPPYESYDKLYEKLLTAIEETCGFAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UJJ2</accession>
    <name>A0A8C2UJJ2_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">1-phosphatidylinositol phosphodiesterase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC107317149</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015724954.1">
        <property type="nucleotide sequence ID" value="XM_015869468.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UJJ2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005036987.1">
        <property type="protein sequence ID" value="ENSCJPP00005027346.1"/>
        <property type="gene ID" value="ENSCJPG00005021214.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107317149"/>
    <dbReference type="KEGG" id="cjo:107317149"/>
    <dbReference type="GeneTree" id="ENSGT00390000010118"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08586">
        <property type="entry name" value="PI-PLCc_BcPLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF113">
        <property type="entry name" value="SI:DKEY-266F7.9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatidylinositol-specific phospholipase C X" evidence="2">
        <location>
            <begin position="30"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005027346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="343" mass="38455" checksum="D730411EE1B2F19C" modified="2022-01-19" version="1">MDARCRRNAAFDNTAEPAAYRPDWMAALPDTLPLSRISIPGTHDSLSLFGGCRLRCQSWGLEAQLEAGVRFLDVRCKLERGELRIYHLCTFQRVSLRGVLRRTLRFLRAHPGEAVLMRIKEEMPIFPRPRFAARLQRCLLEESRGRLWCREEVPTLGQVRGKIVVLEALEQAVLGIPYERLSISDAWNVLSLERKWARAQRHLDTAASGDPATMHLTFCSGNGLFTCPEDVARFVNPQCYQHLQCCSGQPVCWGVVILDFPGAGLLQLIIESNNTSGTNGSVPEAPSTPQTSQRQRRQTLRVAPLGPVSPVLRAASRVSRRTSMRKGARRSCTALRHLYVTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y4Y5</accession>
    <name>A0A8C2Y4Y5_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">RNF6</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the RNF12 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y4Y5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005001384.1">
        <property type="protein sequence ID" value="ENSCJPP00005000792.1"/>
        <property type="gene ID" value="ENSCJPG00005000859.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158530"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016605">
        <property type="term" value="C:PML body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050681">
        <property type="term" value="F:nuclear androgen receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048675">
        <property type="term" value="P:axon extension"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030517">
        <property type="term" value="P:negative regulation of axon extension"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044314">
        <property type="term" value="P:protein K27-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070936">
        <property type="term" value="P:protein K48-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085020">
        <property type="term" value="P:protein K6-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060765">
        <property type="term" value="P:regulation of androgen receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd16673">
        <property type="entry name" value="RING-H2_RNF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000054">
        <property type="entry name" value="E3 ubiquitin-protein ligase RLIM isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051834">
        <property type="entry name" value="RING_finger_E3_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058896">
        <property type="entry name" value="RNF6/12_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931">
        <property type="entry name" value="SI:CH211-59O9.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25914">
        <property type="entry name" value="RNF6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="768"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="67"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="230"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="323"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="658"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="131"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="164"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="230"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="263"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="350"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="389"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="441"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="462"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="496"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="658"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="684"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="698"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005000792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="821" mass="92238" checksum="2E2C344D66D6CB62" modified="2022-01-19" version="1">MRAEIPPVLVTPSLSRPLASVWLRMPGRGRRWAEGRARNSLSRLPAAARTAIGVGTPALSARGRCLSAPAAGREGESRAERGREPGRPAGCRRSGAPGAPRPLFVSGRPAAGRRHGQLPGSAPRVMPLPRGRGRRWRRRSGRWRQPGIMDRSRHRAGNGNEQASSRERGYGEDERQRQLERLSREEAYYQFINELNEEDYRLMRDHNLLGTPGEITAEELQQRLEGAKERLASQTDLENREGEGRTAGENSNGDSLLEWLNTFRRTGNATRSGQSGNQTWRAVSRTNPNSGEFRFSLEININHEHNNFETTGEEYVGIDHSRTYSERRHQRAFSPITARTRSQTRREANSRAASTARTRSLRSSVVQSSEAASHPVSGRLRSRTRESTGLHQTNTTRHSSTTADEQREMPERGTSTRVGRHSRSRTNVQVNRNQRLEILRLRSTLSSRSRSPLQRQSGTAYSEERGQRHDRSTPQASRSRRQTVQHPQQPAEEQARNNAQTPHLSSAPPSSGLTAEEEESSRPVAAVRRHPTITLDLQVRRIRPGENRDRDSIASRTRSRVGMAENTVTFESDSGGFRRTISRSERAGIRTYVSTIRIPLRRISETGLGEPSSVALRSILRQIMTGFGELSSLMETESNSEMQRGAHHLADVRAEQNNSSLVNNSSDPSEVSSRNRQIVEDDSERNGQSDDTRRYGSGNENQDSRQSQDANNLVENGTLPILRLAHFFLLNEDDEDERLRGLTKEQIDNLSTRNYGDIHTDEEISKTCSVCINEYVTGNKLRQLPCMHEFHIHCIDRWLSENSTCPICRQPVLGSNATDSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y702</accession>
    <name>A0A8C2Y702_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Solute carrier family 12 member 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">Na-Cl symporter</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="24">Thiazide-sensitive sodium-chloride cotransporter</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="29" type="primary">SLC12A3</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="29" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="29" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="20">Electroneutral sodium and chloride ion cotransporter, which acts as a key mediator of sodium and chloride reabsorption in kidney distal convoluted tubules. Also acts as a receptor for the pro-inflammatory cytokine IL18, thereby contributing to IL18-induced cytokine production, including IFNG, IL6, IL18 and CCL2. May act either independently of IL18R1, or in a complex with IL18R1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>chloride(out) + Na(+)(out) = chloride(in) + Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:73887"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="21">Homodimer; adopts a domain-swap conformation at the scissor helices connecting the transmembrane domain and C-terminal domain. Interacts with KLHL3. Interacts with IL18R1; this interaction is increased by IL18 treatment.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC12A transporter family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y702"/>
    <dbReference type="Ensembl" id="ENSCJPT00005007678.1">
        <property type="protein sequence ID" value="ENSCJPP00005004613.1"/>
        <property type="gene ID" value="ENSCJPG00005003148.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155044"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070062">
        <property type="term" value="C:extracellular exosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008511">
        <property type="term" value="F:sodium:potassium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006884">
        <property type="term" value="P:cell volume homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055064">
        <property type="term" value="P:chloride ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055075">
        <property type="term" value="P:potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070294">
        <property type="term" value="P:renal sodium ion absorption"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904044">
        <property type="term" value="P:response to aldosterone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902074">
        <property type="term" value="P:response to salt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055078">
        <property type="term" value="P:sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000018">
        <property type="entry name" value="solute carrier family 12 member 3 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013612">
        <property type="entry name" value="AA_permease_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018491">
        <property type="entry name" value="SLC12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002948">
        <property type="entry name" value="SLC12A3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004842">
        <property type="entry name" value="SLC12A_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00930">
        <property type="entry name" value="2a30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827:SF9">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 12 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08403">
        <property type="entry name" value="AA_permease_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03522">
        <property type="entry name" value="SLC12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01230">
        <property type="entry name" value="NACLTRNSPORT"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="18" id="KW-0868">Chloride</keyword>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="14 25" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0915">Sodium</keyword>
    <keyword evidence="17" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="10" id="KW-0769">Symport</keyword>
    <keyword evidence="6 25" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 25" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="210"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="256"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="378"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="544"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="569"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="602"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease N-terminal" evidence="28">
        <location>
            <begin position="111"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="26">
        <location>
            <begin position="183"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="domain" description="SLC12A transporter C-terminal" evidence="27">
        <location>
            <begin position="693"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="domain" description="SLC12A transporter C-terminal" evidence="27">
        <location>
            <begin position="889"/>
            <end position="1092"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00050884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00056815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00063035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00073714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00076232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00077939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF03522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="Pfam" id="PF08403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005004613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1093" mass="118907" checksum="84455DDEC18BC289" modified="2022-01-19" version="1">PPGSQFPSSVGSAPPVTHSAAVVCGISQGSAAGKGQKSRAELTSSPHLGTFSSHPDLLWKTAATTGGTRAATMAELPCAEPLPRCSGRFTISTLLGPEEVLGCEGTQLSGSSLCTRTFGYNTVDVVPAYEHYANSRGVGEARQGRPSLADLHSILKVRLCCGGCCSAPAPEPVRFGWVKGVMVSIRCMLNIWGVILYLRLPWITAQAGIALTWLIILMSVTVTTITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVAVAMHTVGFAETVRDLLQEHNSLIVDPTNDIRIIGVLTVTVLLGISLAGMEWEAKAQILFFLVILVSFINYLVGTVIPASAEKQAKGFFSYRGGFNFVPDWRGPEGSFFGLFSIFFPSATGILAGANISGDLKDPAVAIPKGTLMAIFWTTVSYLVLSATIGACVLRDASGSLNDSVALGSPGCEGLGCSYGWNFTDCAQQQSCRYGLSNYYQVMSMVSGFGPLITAGIFGATLSSALACLVSAPKVFQCLCKDQLYPLIGFFGKGYGKNSEPIRGYMLTYVIAIGFILIAELNAIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFRYYSKWAALFGAAISVVIMFLLTWWAALIALGIVVFLLGYVLYKKPDVNWGSSMQASSYNLALSYSVGLSEVDEHIKNYRPQCLVLTGPPNFRPALVDFVGTFTKNLSLMICGNVLIGPRKQKVPEAQQALDGHTRWLLKRKIKAFYTNVLAEDLRSGVQMLLQAAGLGKMRPNIVALGYKRDWQAAAPQSLEDYVGILHDAFDFKHGVCLLRLREGLNVSRVPQAHSKCCRHAVVGTVLGTILMMGTGTLKPFQLGNEMVPFATVTVVLGDGAVLMSAFPFTADPEQQASTIFQSQQGKKTIDIYWLFDDGGLTLLIPYLLGRKKRWGKCRIRVFVGGQINRMDEERKAIVSLLSKFRLGFHEVHVLPDINQQPRPEHIRRFDELIAPFRLNDGFKDEAAVNELRHGCPWKISDEEVHRHRAKSLRQVRLNEILLDYSRDAALIAITLPIGRKGRCPSSLYMAWLETLSQDLRPPVILIRGNQENVLTFYCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y706</accession>
    <name>A0A8C2Y706_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Neurexophilin 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">NXPH4</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the neurexophilin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y706"/>
    <dbReference type="Ensembl" id="ENSCJPT00005007704.1">
        <property type="protein sequence ID" value="ENSCJPP00005004637.1"/>
        <property type="gene ID" value="ENSCJPG00005004557.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182883"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome LGE22C19W28_E50C23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098982">
        <property type="term" value="C:GABA-ergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050804">
        <property type="term" value="P:modulation of chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010450">
        <property type="entry name" value="Nxph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026845">
        <property type="entry name" value="NXPH/NXPE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17103">
        <property type="entry name" value="NEUREXOPHILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17103:SF10">
        <property type="entry name" value="NEUREXOPHILIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06312">
        <property type="entry name" value="Neurexophilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="42"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005004637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="235" mass="26263" checksum="735B7B11662A5B97" modified="2022-01-19" version="1">PTCLGLAAQWSFKSTPPQRGSLVLGAGGLLKHSPYGAMKPPPVLLPAEPPRSPWDWQHNGTGGDAPSVSRRKPALKSSRSKKIFGWGDFYVSIQTLKFSLLLTGKIVDHVNGTFSVYFRHNSSSLGNVSVSIVPPNRAVGFEVLLPQSTLPEGRNKALNCHVEYEKTDRARRNRPCLYDPSKVCFTEHTQSHVSWVCSKPFKVICIYIAFYSVDYKLVQKVCPDYNFQHEHPYFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y7Q8</accession>
    <name>A0A8C2Y7Q8_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">N-alpha-acetyltransferase 30</fullName>
            <ecNumber evidence="13">2.3.1.256</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">N-acetyltransferase 12</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">N-acetyltransferase MAK3 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">NatC catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">NAA30</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N-terminal L-methionyl-L-isoleucyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-isoleucyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50524"/>
            <dbReference type="Rhea" id="RHEA-COMP:12713"/>
            <dbReference type="Rhea" id="RHEA-COMP:12714"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133379"/>
            <dbReference type="ChEBI" id="CHEBI:133380"/>
            <dbReference type="EC" id="2.3.1.256"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N-terminal L-methionyl-L-leucyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-leucyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50520"/>
            <dbReference type="Rhea" id="RHEA-COMP:12711"/>
            <dbReference type="Rhea" id="RHEA-COMP:12712"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133377"/>
            <dbReference type="ChEBI" id="CHEBI:133378"/>
            <dbReference type="EC" id="2.3.1.256"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N-terminal L-methionyl-L-phenylalanyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-phenylalanyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50528"/>
            <dbReference type="Rhea" id="RHEA-COMP:12715"/>
            <dbReference type="Rhea" id="RHEA-COMP:12716"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133382"/>
            <dbReference type="ChEBI" id="CHEBI:133383"/>
            <dbReference type="EC" id="2.3.1.256"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N-terminal L-methionyl-L-tryptophyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-tryptophyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50560"/>
            <dbReference type="Rhea" id="RHEA-COMP:12724"/>
            <dbReference type="Rhea" id="RHEA-COMP:12725"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133386"/>
            <dbReference type="ChEBI" id="CHEBI:133387"/>
            <dbReference type="EC" id="2.3.1.256"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-methionyl-L-tyrosyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-tyrosyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50532"/>
            <dbReference type="Rhea" id="RHEA-COMP:12717"/>
            <dbReference type="Rhea" id="RHEA-COMP:12718"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133384"/>
            <dbReference type="ChEBI" id="CHEBI:133385"/>
            <dbReference type="EC" id="2.3.1.256"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the acetyltransferase family. MAK3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.256" evidence="13"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y7Q8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005010359.1">
        <property type="protein sequence ID" value="ENSCJPP00005006586.1"/>
        <property type="gene ID" value="ENSCJPG00005006116.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000005665"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120518">
        <property type="term" value="F:protein N-terminal-methionine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000010">
        <property type="entry name" value="Putative N-alpha-acetyltransferase 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044542">
        <property type="entry name" value="NAA30-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45896">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45896:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="19">
        <location>
            <begin position="265"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="91"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="200"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="221"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00050754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00052362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00066994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00071796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00076746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00078622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00079214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="419" mass="45179" checksum="1ECE102534467E7D" modified="2022-01-19" version="1">MAEVPPGPSSVLSPQGDTLSPFPGGGGGGPASSSSCSTSAAAAAACTGAQDEEAEEEEEEEEEEEGPAGGREQQRGGSSDGGKGGPQQQQHRLHHHHHHPPHHNHQLNGLISPELRHLRASLKSKILGSEAGAAPEGLENKRASKTMGSGQQQQQQPSPPASAPCSSPLSNHLPPQGRTAPSPPPSPAAAAAIGDRSQPAATTTTAAKTAARNGLAGGTGLEEEEQEEGDEGGEEEESLLLLSRSLAAGCSLKGSGTDCQPEEDLTIRYVRYESELQMPDIMRLITKDLSEPYSIYTYRYFIHNWPQLCFLVSRGYNNNRCVGAIVCKLDMHKKMFRRGYIAMLAVDSKYRRKGIGTNLVKKAIYAMVEGDCDEVVLETEITNKSALKLYENLGFVRDKRLFRYYLNGVDALRLKLWLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y8E5</accession>
    <name>A0A8C2Y8E5_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y8E5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005011753.1">
        <property type="protein sequence ID" value="ENSCJPP00005007619.1"/>
        <property type="gene ID" value="ENSCJPG00005006977.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00520000060950"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052748">
        <property type="entry name" value="ISR_Activator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45011">
        <property type="entry name" value="DAP3-BINDING CELL DEATH ENHANCER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45011:SF1">
        <property type="entry name" value="DAP3-BINDING CELL DEATH ENHANCER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005007619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="152" mass="16760" checksum="4DAB820DD2671D7C" modified="2022-01-19" version="1">MAASNLDGKLRASQCSCYLRQSYVLITVAHSTLSSVGFVFLCIPLCYQAFHFHVAQAYAHLGYPHAQHIVGQRYLQGAGVEKNEELAMHWFRQAAGQGHPHSSFNLALGALSNMTAALEEREVEKLLGVAAAHGLREAQELLENIQKSRKMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y8R4</accession>
    <name>A0A8C2Y8R4_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Potassium channel tetramerization domain containing 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">KCTD10</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BACURD family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015733535.1">
        <property type="nucleotide sequence ID" value="XM_015878049.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y8R4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005013140.1">
        <property type="protein sequence ID" value="ENSCJPP00005008699.1"/>
        <property type="gene ID" value="ENSCJPG00005007752.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107321295"/>
    <dbReference type="CTD" id="83892"/>
    <dbReference type="GeneTree" id="ENSGT00950000183143"/>
    <dbReference type="OrthoDB" id="2333377at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031463">
        <property type="term" value="C:Cul3-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005112">
        <property type="term" value="F:Notch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035024">
        <property type="term" value="P:negative regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18399">
        <property type="entry name" value="BTB_POZ_KCTD10_BACURD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000013">
        <property type="entry name" value="BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045068">
        <property type="entry name" value="BACURD1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11145">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING ADAPTER FOR CUL3-MEDIATED RHOA DEGRADATION PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11145:SF14">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING ADAPTER FOR CUL3-MEDIATED RHOA DEGRADATION PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="BTB" evidence="7">
        <location>
            <begin position="32"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="283"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005008699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="313" mass="35402" checksum="1654FF357BDD8065" modified="2022-01-19" version="1">MEEMSGEGVVSSAVPAAATRTTSFKGTSPSSKYVKLNIGGALYYTTMQTLTKQDTMLKAMFSGRMEVLTDSEGWILIDRCGKHFGTILNYLRDGAVPLPESRREIEELLAEAKYYLVQGLVDECQAALQNKDAYEPFCKVPVITSSKEEQKLIATSNKPAVKLLYNRSNNKYSYTSNSDDNMLKNIELFDKLSLRFNGRVLFIKDVIGDEICCWSFYGQGRKIAEVCCTSIVYATEKKQTKVEFPEARIYEETLNILLYESQDGRGPDNALLEATGGAAGRSHHLEEDEERERIERVRRIHIKRPDDRAHLHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y8V3</accession>
    <name>A0A8C2Y8V3_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the Sp1 C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y8V3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005013429.1">
        <property type="protein sequence ID" value="ENSCJPP00005008928.1"/>
        <property type="gene ID" value="ENSCJPG00005007897.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286934"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000077">
        <property type="entry name" value="Sp8 transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000014">
        <property type="entry name" value="Transcription factor Sp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001732">
        <property type="entry name" value="Zgc:162936"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000706">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000478">
        <property type="entry name" value="Zinc finger protein 133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001158">
        <property type="entry name" value="zinc finger protein 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000269">
        <property type="entry name" value="Zinc finger protein 287"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000848">
        <property type="entry name" value="Zinc finger protein 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001090">
        <property type="entry name" value="zinc finger protein 629 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000495">
        <property type="entry name" value="zinc finger protein 668"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000336">
        <property type="entry name" value="zinc finger protein 768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050752">
        <property type="entry name" value="C2H2-ZF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24384">
        <property type="entry name" value="FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24384:SF242">
        <property type="entry name" value="ZINC FINGER PROTEIN 628"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="102"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="132"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="193"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="221"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="249"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="277"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="348"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="376"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="404"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="61"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005008928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="533" mass="59674" checksum="6E45EBED57B9E830" modified="2022-01-19" version="1">MYVYIDGLLYIKAEKSRTEGEGNRVKGGDWGWGVIGVWGVMWGCLRGGLSPLPWGCREIKERKSGSGEGGGRRGGEHRATAPTARRPSGWGRRGSLRSKGLHSCHIPGCGKVYGKTSHLKAHLRWHTGERPFVCNWLFCGKRFTRSDELERHVRTHTREKKFTCPHGRALGHPHAMGPLEELLGLRGGRLRPTICGECGKGFSRSSDLVRHRITHTGEKPYTCGACGKGFSQNSNLVTHQRIHTGEKPYSCGTCGKRFSESSALIQHQRTHTGEKPYSCPDCGKCFSRSSHLNRHRRTHSDEKPYICVECGEGFRHKSQLRRHQKLHSTYTGRNGIGGRPRGGRQRPFICNECGKSFSHWSKLLRHQRTHTGERPSTCGECGKSFSQNSHLVQHRRTHTGEKPYRCGDCGKSFSWSSNLIQHQRIHTGEKPYSCGQCGKSFTQKLSPNIQPKSSLLQLKTISPSPAIISPFEEFTPLLGVSSLQVLKGCTESSSPSLYRCMQLFLPTCKTLHLLLLNLIRFLTAQLSSLSRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y9F5</accession>
    <name>A0A8C2Y9F5_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pantetheinase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">VNN1</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y9F5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005015125.1">
        <property type="protein sequence ID" value="ENSCJPP00005010164.1"/>
        <property type="gene ID" value="ENSCJPG00005008903.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000013823"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017159">
        <property type="term" value="F:pantetheine hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015939">
        <property type="term" value="P:pantothenate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07567">
        <property type="entry name" value="biotinidase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.110.10:FF:000001">
        <property type="entry name" value="biotinidase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012101">
        <property type="entry name" value="Biotinidase-like_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040154">
        <property type="entry name" value="Biotinidase/VNN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043957">
        <property type="entry name" value="Vanin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10609">
        <property type="entry name" value="BIOTINIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10609:SF27">
        <property type="entry name" value="CN HYDROLASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19018">
        <property type="entry name" value="Vanin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011861">
        <property type="entry name" value="Biotinidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034967779" evidence="6">
        <location>
            <begin position="23"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="CN hydrolase" evidence="7">
        <location>
            <begin position="31"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR011861-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005010164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="507" mass="56645" checksum="4BE5EF17E8B1CA66" modified="2022-01-19" version="1">MVPSQTLLCAAVLALAVLQALASDTFIAAVYEHAVILPRTAHKVSPDDALALMNKNMDVLERAIKEAAQQGAHIIVTPEDGIYGWVFTRETIYPYLEDIPDPEVNWIPCTDPTRFGRAPVQERLSCMARNNSIYVVANIGDKKPCNSSDPKCPSDGRYQYNTDVVFDSEGKLVARYHKYNLFMSEAKHFNYPKEPEAITFETPFGKFGIFTCFDILFREPAVVLASELQVDTVLFPTAWMNVLPFLTAVEFHSAWAMGMGVNFLASNTHNTIMSMTGSGIYAPDGAKAYYYNMKTVDGHLLIAKLDSHPHLSPASPPAVSWSLYASNVESCLPDEKDFSGLIFHDQFTFTELTKPEGSLTVCQKDLRCHLSYKMAEKREDEVYVLGAFDGLHVVEGQYYLQICTLLKCKNTDLSTCGQPVETAQTKFDMFSLSGTFGTNYVFPEVLYSGVQLAPGEFEVLSDGRLQSKNGTSKPLLTVTLFGRCYEKDLPHPLRSFLYPHNKKRKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y9Q4</accession>
    <name>A0A8C2Y9Q4_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TNF receptor-associated factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">TRAF1</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Adapter molecule that regulates the activation of NF-kappa-B and JNK. Plays a role in the regulation of cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex recruits the antiapoptotic E3 protein-ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y9Q4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005015379.1">
        <property type="protein sequence ID" value="ENSCJPP00005010369.1"/>
        <property type="gene ID" value="ENSCJPG00005009035.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161076"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031996">
        <property type="term" value="F:thioesterase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005164">
        <property type="term" value="F:tumor necrosis factor receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043122">
        <property type="term" value="P:regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001236">
        <property type="term" value="P:regulation of extrinsic apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03779">
        <property type="entry name" value="MATH_TRAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000053">
        <property type="entry name" value="TNF receptor-associated factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.210.10:FF:000001">
        <property type="entry name" value="TNF receptor-associated factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049342">
        <property type="entry name" value="TRAF1-6_MATH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037306">
        <property type="entry name" value="TRAF1_MATH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032070">
        <property type="entry name" value="TRAF_BIRC3-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131">
        <property type="entry name" value="TNF RECEPTOR ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131:SF96">
        <property type="entry name" value="TNF RECEPTOR-ASSOCIATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21355">
        <property type="entry name" value="TRAF-mep_MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16673">
        <property type="entry name" value="TRAF_BIRC3_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="MATH" evidence="8">
        <location>
            <begin position="254"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00055962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00072835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005010369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="403" mass="45220" checksum="3EA4ABC25EF80881" modified="2022-01-19" version="1">CVRSSGSSSPDENEFPFGYPTSICEDVPEQKYLCSNCNNVLKKALNNKNPVCQKCKEEDPNTLSEGSLLAEERVSCGSQPIQKIKEHEKAAVGTHMLLLLQYIKQLKANLCTTRAANGFIPQTELNVNGAEKSISELCIPGSLQINGGLEMDCLTRTSVPRDESIVQQLVREKVISELENKLHVFENIVAVLNKEVETSNLEITAFRRQSELDQNIIRGLERKIAELHRCLSQKDAGLSRLHKSLVFSEQTSYDGVFLWKITDVSQKLQDSVTGRAVSLYSPAFYTAKYGYKVCLRIYLNGDGMGKGTHVSLFFVVMKGDYDALLPWPFRHKVTFMLLDQNNREHIIDAFRPDLTSASFQRPVSDMNVASGCPTFLPLTKLQSPKHAYVKEDTLFLKCIIDTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y9U4</accession>
    <name>A0A8C2Y9U4_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y9U4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005015693.1">
        <property type="protein sequence ID" value="ENSCJPP00005010633.1"/>
        <property type="gene ID" value="ENSCJPG00005009224.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00960000187061"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005010633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="179" mass="20953" checksum="DB23F17B85EEECA7" modified="2022-01-19" version="1">MVKSSSPIYSHVCLLSVQFYRPSCRKTHTKLKQNSQKLLKTYKLRIYLILTLTSLHLLAEFDVFITMVFGHFLSSSFVGSLIRRIIVCHSDPMRFHWMPLSIVICHTILPCQTPFYRTAPLLPSVTGQQHIREYYTESQNYQGWKRPRRSSSPAITNTSQLNHIHQHNIQMFLEHSHGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YAF3</accession>
    <name>A0A8C2YAF3_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 14">Ribokinase</fullName>
            <shortName evidence="14">RK</shortName>
            <ecNumber evidence="2 14">2.7.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 17" type="primary">RBKS</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>D-ribose + ATP = D-ribose 5-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13697"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:47013"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14">Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="14">Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="14">Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbohydrate kinase pfkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.15" evidence="2 14"/>
    <dbReference type="RefSeq" id="XP_015712900.1">
        <property type="nucleotide sequence ID" value="XM_015857414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YAF3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005017353.1">
        <property type="protein sequence ID" value="ENSCJPP00005011917.1"/>
        <property type="gene ID" value="ENSCJPG00005010186.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107311137"/>
    <dbReference type="KEGG" id="cjo:107311137"/>
    <dbReference type="CTD" id="64080"/>
    <dbReference type="GeneTree" id="ENSGT00390000005743"/>
    <dbReference type="OrthoDB" id="415590at2759"/>
    <dbReference type="UniPathway" id="UPA00916">
        <property type="reaction ID" value="UER00889"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004747">
        <property type="term" value="F:ribokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019303">
        <property type="term" value="P:D-ribose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01174">
        <property type="entry name" value="ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.20:FF:000022">
        <property type="entry name" value="Ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01987">
        <property type="entry name" value="Ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011877">
        <property type="entry name" value="Ribokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02152">
        <property type="entry name" value="D_ribokin_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584:SF166">
        <property type="entry name" value="RIBOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13 14" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 14 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11 14" id="KW-0630">Potassium</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
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        </source>
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            <dbReference type="Ensembl" id="ENSCJPP00005011917.1"/>
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    </evidence>
    <sequence length="309" mass="32712" checksum="2A595CE4FF61775A" modified="2022-01-19" version="1">MAAEVAVVGSCMTDLVSFTTRLPRAGETILGQKFFIGFGGKGANQCVQSARLGARTSLICKVGKDSFGNDYVANLKKNGVSTAFVGQTADAVTGTASIIVNSEGQNVIVIVPGANLLLSSEDLKRASDIICKAKVAVCQLEITPAVSLEALKMAHASGVKTLFNPAPALADLDPEFYTHSDIFCCNETEAEILTGIPVGNLEDAEKVGRMLLERGCKLVIVTLGAEGCMMISVEEPIPKHVPAEKVRAVDTTGAGDSFVGALAFYLAHYPELPVEEMVRKSNYIASVSVQASGTQSSYPYRKDLPQDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YBP3</accession>
    <name>A0A8C2YBP3_COTJA</name>
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        <recommendedName>
            <fullName evidence="2">G patch domain-containing protein 11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Coiled-coil domain-containing protein 75</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">GPATCH11</name>
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    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
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    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPATCH11 family.</text>
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        <property type="nucleotide sequence ID" value="XM_015857571.2"/>
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    <dbReference type="KEGG" id="cjo:107311234"/>
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        <property type="term" value="F:nucleic acid binding"/>
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        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21032:SF0">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 11"/>
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    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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            <dbReference type="ARBA" id="ARBA00007140"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00030688"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005014576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="256" mass="29680" checksum="BEDDB819B556129D" modified="2022-01-19" version="1">MGDEEEEDYMSDLFIKEDVRPGVPMVRRVREALQKEEKQKEANEKNRQKSVKEEEKERRDLVLSSALGNENKGFALLQKMGYKSGQALGKSGEGIVEPIPLNIKTGRSGLGHEEFKKRKAEEKLENYRQKLHMKKQANEQAADQFRIRFKNKQEERKMEGDLRKSQRACQQLDIQKDIKAPKEIWYWLQPEEEDQKDEDDKDDECAGSDLSVSAKLQILTAYLREEHFYCIWCGTTYEDAEDLSSNCPGDSAADHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YC34</accession>
    <name>A0A8C2YC34_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Renalase, FAD dependent amine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">RNLS</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YC34"/>
    <dbReference type="Ensembl" id="ENSCJPT00005022181.1">
        <property type="protein sequence ID" value="ENSCJPP00005015679.1"/>
        <property type="gene ID" value="ENSCJPG00005012954.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000016052"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051379">
        <property type="term" value="F:epinephrine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="F:monoamine oxidase activity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070404">
        <property type="term" value="F:NADH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045776">
        <property type="term" value="P:negative regulation of blood pressure"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010459">
        <property type="term" value="P:negative regulation of heart rate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040174">
        <property type="entry name" value="RNLS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23357">
        <property type="entry name" value="RENALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23357:SF1">
        <property type="entry name" value="RENALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034357153" evidence="4">
        <location>
            <begin position="18"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="5">
        <location>
            <begin position="99"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="349" mass="38309" checksum="0EC213F0500156D1" modified="2022-01-19" version="1">MARVLVVGAGLTGSVCAALLQGATRERVCVWDKARGAGGRMSTSRSALDAACTADLGAQYITRSAGQRGRFYEELLCHGILEPLSARIEGLMEKEGSCDYVAPQGISSVVKYYLRQSGADVFYEHHVTHISLRGGKWEVSRKMASPELFDVVILTMPVPQILQLQGDIVNIINERQKQQLESAHYSSRYALGLFYEVGARIDVPWAAKYITDNPCIRFISIDNKKRNIDSPEIGPSVVVHTTVTFGTEHLDSDPAEVQQLILSHLESLVPSLPKAASVKCQKWRYSQVTKAVPNCPGQMILHTQPLLICGFCWLFFFLIASNSFGTSSAFGKYTSSYRDSVGNSAPSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YD49</accession>
    <name>A0A8C2YD49_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC107319301</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BtpA family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2YD49"/>
    <dbReference type="Ensembl" id="ENSCJPT00005024599.1">
        <property type="protein sequence ID" value="ENSCJPP00005017662.1"/>
        <property type="gene ID" value="ENSCJPG00005014392.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000006020"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005137">
        <property type="entry name" value="BtpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00259">
        <property type="entry name" value="thylakoid_BtpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21381:SF3">
        <property type="entry name" value="SGC REGION PROTEIN SGCQ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21381">
        <property type="entry name" value="ZGC:162297"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03437">
        <property type="entry name" value="BtpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034958780" evidence="2">
        <location>
            <begin position="23"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005017662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="297" mass="31444" checksum="F28F6E4E67965605" modified="2022-01-19" version="1">MAGPRLFGRLRAAVLGVVHVAALPGTPRNSLPLAQIIEQACQEAEDYKDAGVDGLIVENMHDRPYTLSPGPEVTAAMTAVGTAVRRLCPHLALGVQVLCAANQQATAVALAAGLDFIRVEGFVFSHVADEGIVNACAGDLLRYRKLVGAENIQIFADIKKKHSAHALTADISVAETASAAELFLADGVILTGTATGQPADPGELREVQHAVKIPVLIGSGVTLENVKNYLDANALIIASSNSFVPLQNSIKDVTNCQVPSSTQGVIMMESFLPELTVVCMQRMIRVLNWLLVDSDSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YF23</accession>
    <name>A0A8C2YF23_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">NAGPA</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YF23"/>
    <dbReference type="Ensembl" id="ENSCJPT00005029939.1">
        <property type="protein sequence ID" value="ENSCJPP00005021840.1"/>
        <property type="gene ID" value="ENSCJPG00005017440.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234566"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033299">
        <property type="term" value="P:secretion of lysosomal enzymes"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018711">
        <property type="entry name" value="NAGPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40446">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-1-PHOSPHODIESTER ALPHA-N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40446:SF2">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-1-PHOSPHODIESTER ALPHA-N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09992">
        <property type="entry name" value="NAGPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="409"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="2">
        <location>
            <begin position="348"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005021840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="478" mass="51596" checksum="130747C8F781DC5A" modified="2022-01-19" version="1">AGQHGPRHGHRHVRACQPVRHGNVTHEAWPGDNSTGLPAATTRTFVSYIPSAQERSRAVYGHFTFVRNPLRTFSVLEPGGAGGCEEQRRVPVEETARLGRCLVAQNGGYFDMSSGECLGNVVSDGRMVRNAHGLQNAQFGIRRDGTMVFGYLSEEDVLDQANPFVQLVSGVVWLLRDGEVYINQSQIAECDETQTTGTFEKFINVISARTAVGHDSQGQLVLVHVDGQTESRGINLWEMAEFLKQQGIINAINLDGGGSATLVLNGTLASYPSEHCSFDNMWRCPRSISTIVCVHEPACEPADCNGHGDCVQGQCHCAGDFWSGPACDTLDCGPSNCSLHGTCTASGCLCDAGWVGSNCSEACPMGWYGPNCQQLCACEHSCPCNPQTGSSGQEMLLMWIFLLSDRSTWISATFVLALLLAVSAMGNVGLFLKARSERQHGGGEYRYHPLRENGEASHTLTSAACEAEDAQDQSQTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YFQ9</accession>
    <name>A0A8C2YFQ9_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc finger protein 518B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ZNF518B</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015718308.1">
        <property type="nucleotide sequence ID" value="XM_015862822.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015718309.1">
        <property type="nucleotide sequence ID" value="XM_015862823.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015718310.1">
        <property type="nucleotide sequence ID" value="XM_015862824.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015718311.1">
        <property type="nucleotide sequence ID" value="XM_015862825.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YFQ9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005031835.1">
        <property type="protein sequence ID" value="ENSCJPP00005023197.1"/>
        <property type="gene ID" value="ENSCJPG00005018438.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107314002"/>
    <dbReference type="KEGG" id="cjo:107314002"/>
    <dbReference type="CTD" id="85460"/>
    <dbReference type="GeneTree" id="ENSGT00940000160595"/>
    <dbReference type="OrthoDB" id="8069632at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="170"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="198"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="11"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="830"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="830"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="862"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="880"/>
            <end position="894"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005023197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1084" mass="122315" checksum="0C4707A5CE9A1A50" modified="2022-01-19" version="1">MQLKKMREILPRLYPGQVNDKNNSLTTSPKQSFEDKTNPSNGDDDQNYCYQGTEAENNKLSLISCMKCRNIQKVSKQDLEKHKKLGWTEDKNFICKMCSHITPPVFHFVPEGANAVDCEKHEKTYPRKKQKAFKVKNFLPGKYYCDKCRFSTKDPLQYKKHVRQHEEIKFICSYCNNISYTKGGFQRHLVKHTGIFPYQCEYCEYGAVRNDYIVKHTRRVHEAPKKQLSNTGLKRQQKKSGLPSQSTLFEKQKYEEIAFQNELSNSSSSITCEILDKATKIVSSPHDIERSINAALIQNETVLEPSEISMCENQSVEVEVYSPKMEPLQPGMPLTVIAPSELVVPSNCLAQIVEIKIVNGAQQLVLKLIPMKEAACRPVNRAELGLENQGTERTAEGKKTYLSSNELLTMEVNVDKLSSISNQLNLDSNYDKNSECLYSSDSQYSDCNSASVQKEDSSKLCLHLVKGIDVHSGVIELCSQSLVTNSTEKKCDLKSPKRGVDVKNKLRYDLYCYEEGVDTSCPKYATVSEDKSSRNNSVKATRESKNFYSSAVLKQKDMFPLKRDDKECRSPIVNSAETHLAAKGFDRKSVACSEAEKNFHVTKASPWEDMTFSFSKVKKAETVSQQNNLLLESLELQKMENKNKPFEGPVISSVFSLSSGAENVPEGIKWDDTARNKKSTTLLCRKIAQLMSAAESNMKSMPLRCQASSKKMHFSQENSASCVRAASASELEQAMSFPQVHGGNNVMGSEEQSNEQLLTFARTSKSRLSKNSNVASPVFIPKGTVLRVLNAASSQNSRGMEKMSEASAPSSYCNEMLLPRPVPVSVSEKLSSNLPCLPNQSDPNTQSRNISLRQRPKREMNAKTSSKQTVVPYQKNGYISKQSKPYSKSQQGPKNKVKQTGFRELPKRKTRTQSETSSGSDMSYLLTARRLRLVPLRMNQLIKCPRRNQPVVVLNHPDVDTPEIINVMKTINKYKGHVLKVVLSERTSSCLGVKRYRKRLTLQNAETGSQGKKQSMLKMKLKKTHKNNYQVVEASPAEALKCMFKCWFCGRVYADQEEWISHGQRHLIEATKGWDVLSLPVTKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YFS9</accession>
    <name>A0A8C2YFS9_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GrpE protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">GRPEL1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Probable component of the PAM complex at least composed of a mitochondrial HSP70 protein, GRPEL1 or GRPEL2, TIMM44, TIMM16/PAM16 and TIMM14/DNAJC19. Binds to HSP70, HSC70 and HSJ1B.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the GrpE family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015718294.1">
        <property type="nucleotide sequence ID" value="XM_015862808.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YFS9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005032023.1">
        <property type="protein sequence ID" value="ENSCJPP00005023366.1"/>
        <property type="gene ID" value="ENSCJPG00005018547.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107313999"/>
    <dbReference type="KEGG" id="cjo:107313999"/>
    <dbReference type="CTD" id="80273"/>
    <dbReference type="GeneTree" id="ENSGT00390000005589"/>
    <dbReference type="OrthoDB" id="201635at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.22.10:FF:000002">
        <property type="entry name" value="GrpE protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.20.20:FF:000003">
        <property type="entry name" value="GrpE protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="GRPE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237:SF25">
        <property type="entry name" value="GRPE PROTEIN HOMOLOG 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="Coiled-coil domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01071">
        <property type="entry name" value="GRPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005023366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="221" mass="24640" checksum="0F95AE46F7C1B01E" modified="2022-01-19" version="1">MAAVAQCVWGSLRSRSPLLGLALRTSPRLLCVATQKSTGQNLEEDQGQSHNEQKAEPSAAERMVTEEKAKLEEQLKEVTDKYKRALADAENVRQRSQKLVEEAKLYGIQSFCKDLLEVADILEKATQSVPKEEIKDENPHLKSLYEGLVMTEVQIQKVFKKHGLLRLDPVGAKFDPYEHEALFHAPMEGKEPGTIALVSKIGYKLHGRTLRPALVGVVKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YG19</accession>
    <name>A0A8C2YG19_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Rho GTPase activating protein 22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ARHGAP22</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015722152.1">
        <property type="nucleotide sequence ID" value="XM_015866666.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YG19"/>
    <dbReference type="Ensembl" id="ENSCJPT00005032642.1">
        <property type="protein sequence ID" value="ENSCJPP00005023894.1"/>
        <property type="gene ID" value="ENSCJPG00005018882.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107315849"/>
    <dbReference type="CTD" id="58504"/>
    <dbReference type="GeneTree" id="ENSGT00950000183015"/>
    <dbReference type="OrthoDB" id="185175at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099175">
        <property type="term" value="P:regulation of postsynapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13378">
        <property type="entry name" value="PH_RhoGAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04390">
        <property type="entry name" value="RhoGAP_ARHGAP22_24_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000120">
        <property type="entry name" value="rho GTPase-activating protein 22 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000015">
        <property type="entry name" value="rho GTPase-activating protein 25 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051025">
        <property type="entry name" value="RhoGAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15228:SF22">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15228">
        <property type="entry name" value="SPERMATHECAL PHYSIOLOGY VARIANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="6">
        <location>
            <begin position="37"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="7">
        <location>
            <begin position="155"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="376"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="614"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="421"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005023894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="705" mass="78791" checksum="E3AC381991EA0CAE" modified="2022-01-19" version="1">MLSPRIRQAKRARSKSLVMGEQIGPPSRPSSPNPQERVVKCGWLKKQRSIMKNWQQRWFVLRGDQLFYYKDEEETKPQGLILLQGNQVNELPPNPDEPGKHLFEIAAGGAGDREKMPVNHEAFLLMANSQNEMEDWVKAIRRVIWAPFGGGIFGQRLEDTVQYERKYGQRLAPLLVEQCVDFIRERGLTEEGLFRMPGQANLVKDLQDSFDCGEKPLFDSNTDVHTVASLLKLYLRELPEPVIPFAKYEDFLSCGQLLSKDEGEGTQELVKQVKNLPQANYNLLKYICKFLDEVQAHSSVNKMSVQNLATVFGPNILRPKMEDPVTMMEGTSLVQHLMTVLISEQGRIFAVPQADVPGSQLEIRPVRPRNTVEWISEEDGEDSRSENNVPSPADLPSDNAVALEATPGPALKNTPPEHSSKLAQPATSPSKRVQTLPPWKYSFRQQGARSGSPKLGSSSLDIPNLSSSGNWLMNGLYSLRGHRRTASGERVKDSCSSQRLSTYDNVPSSSLSLSTHSIGSTTWSTSSCEISVVDSVSSCPACRASDSSALSSLQTEWMTQGSLSQSEVKTPDLENSIDRLEACSSSSEQSNLAPASRDSVRCSRALQSLVVELKTELSKQRTEYETSIKRIEEASADLRKQVVRLEEELDQERKKYTMLEIKLRNSERAREDAEKRNHLLQKEMEEFFSTLGCLTGGSQSAKVPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SMK7</accession>
    <name>A0A8C2SMK7_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RCSD domain containing 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">RCSD1</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015734640.1">
        <property type="nucleotide sequence ID" value="XM_015879154.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SMK7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005001788.1">
        <property type="protein sequence ID" value="ENSCJPP00005001027.1"/>
        <property type="gene ID" value="ENSCJPG00005001108.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107321808"/>
    <dbReference type="KEGG" id="cjo:107321808"/>
    <dbReference type="CTD" id="92241"/>
    <dbReference type="GeneTree" id="ENSGT00940000153997"/>
    <dbReference type="OrthoDB" id="9450049at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071203">
        <property type="term" value="C:WASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901981">
        <property type="term" value="F:phosphatidylinositol phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905394">
        <property type="term" value="F:retromer complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071474">
        <property type="term" value="P:cellular hyperosmotic response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036010">
        <property type="term" value="P:protein localization to endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003009">
        <property type="term" value="P:skeletal muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029341">
        <property type="entry name" value="FAM21/CAPZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21669:SF2">
        <property type="entry name" value="CAPZ-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21669">
        <property type="entry name" value="CAPZ-INTERACTING PROTEIN AND RELATED PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15255">
        <property type="entry name" value="CAP-ZIP_m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM21/CAPZIP" evidence="3">
        <location>
            <begin position="81"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="102"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="55"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="212"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="309"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="345"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005001027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="370" mass="39980" checksum="DD860EFCDD5DD75E" modified="2022-01-19" version="1">MENRPTETNSEVDKSGSPSVAQLAGKFKEQAASITGKEVPPHKPTRRKPPCSLPLYSNKTETSQNNGQKPSPNACPIPKVKVKSSPMIEKLQANLAFAPAALLPGASPKSPGLKVMVSPFSTPPSTPSSPGIQPQSSEASETPVSFDKPPEGTQLQFYNKVRTRGSIKRRPPSRKFRRSLSDYGDGEDLGNFIPSPENGTKEDGDEVFGHQGKTEEAETGNKEIKKQTVPDEKPPSRRGSSRSDNEEKEEKQAEKVTPCKSNAGDTEKEEEEVCCGAPGENSPQSPSEDKEDKVCEASQETEEEGGACEQEKEEKEKEEAEEKETSESTVTQRTSDAEETPVAPQPQQEAVGSETASEPLTSPVQDQGTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SN80</accession>
    <name>A0A8C2SN80_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxidative stress induced growth inhibitor family member 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">OSGIN2</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015711400.1">
        <property type="nucleotide sequence ID" value="XM_015855914.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SN80"/>
    <dbReference type="Ensembl" id="ENSCJPT00005000521.1">
        <property type="protein sequence ID" value="ENSCJPP00005000263.1"/>
        <property type="gene ID" value="ENSCJPG00005000353.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107310360"/>
    <dbReference type="KEGG" id="cjo:107310360"/>
    <dbReference type="CTD" id="734"/>
    <dbReference type="GeneTree" id="ENSGT00390000006658"/>
    <dbReference type="OrthoDB" id="412005at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030308">
        <property type="term" value="P:negative regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000087">
        <property type="entry name" value="oxidative stress-induced growth inhibitor 2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029731">
        <property type="entry name" value="OSGIN1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15192:SF4">
        <property type="entry name" value="OXIDATIVE STRESS-INDUCED GROWTH INHIBITOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15192">
        <property type="entry name" value="PROTEIN CBG05349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005000263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="554" mass="61511" checksum="7138CD9FE96BA054" modified="2022-01-19" version="1">MPVWCCRCSLAGPVRNYNSSETEGQLLNSFGQYFGDSLGKKIKKMPLLEETVLPGDSLLSLPVVIIGNGPSGICLSYLLSGYRPYLSPEAVHPNPILHTKLEEARHLSIVDQDLEYLSEGLEGRSSNPVAVLFDTLLHPDADFGYDYPSVLHWKLEQHNYIPHVVLGKGPPGGAWHAMEGSMLTISLGDWMELPGLTFKEWAASKRRTIKSDRVMPEEIACYYKHYVKVMGLQKNFRDNVYITSVSRLYRGDDEDRSQLNDNIPTQHLEMEDGQKPLIKRNWEVRGYQRAADGSHVPFCLFAENVALATGTFDSPGRLHVEGEDFPFVLHSMSDFGAAVSKGKLRGKADPVLIVGAGLTAADAVLCAYNNNIPVIHVFRRRVTDSSLIFKQLPKKLYPEYHKVYHMMCTQSHTGDSNLHSAYTSFPEHNVLSFKPEMKCVLQSASGLKKILKFSVALVLIGSHPNLFFLKDQGHGIGHHLNQPITCKGNPIEIDPYTYECTKEANLFALGPLVGDNFVRFLKGGALGIARCLAIRQKKKQELMESGDGGGDGVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SN85</accession>
    <name>A0A8C2SN85_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein LBH</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LBH</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the LBH family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SN85"/>
    <dbReference type="Ensembl" id="ENSCJPT00005002185.1">
        <property type="protein sequence ID" value="ENSCJPP00005001288.1"/>
        <property type="gene ID" value="ENSCJPG00005001339.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000009189"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:negative regulation of intracellular estrogen receptor signaling pathway"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:negative regulation of stem cell differentiation"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:positive regulation of somatic stem cell population maintenance"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:regulation of MAPK cascade"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013294">
        <property type="entry name" value="LBH"/>
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    <dbReference type="InterPro" id="IPR038990">
        <property type="entry name" value="LBH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042945">
        <property type="entry name" value="LBH_dom_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14987:SF2">
        <property type="entry name" value="PROTEIN LBH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14987">
        <property type="entry name" value="PROTEIN LBH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15317">
        <property type="entry name" value="Lbh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008130">
        <property type="entry name" value="LBH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01881">
        <property type="entry name" value="LBHPROTEIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="LBH" evidence="10">
        <location>
            <begin position="3"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="64"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="65"/>
            <end position="75"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010862"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00017731"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF15317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005001288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
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    </evidence>
    <sequence length="85" mass="9745" checksum="9A7DA3841C89B5B7" modified="2022-01-19" version="1">MMSSPAMDEIGLSPRKDGLSYQIFPDPSDFDCYCKLKDRLPSIVVEPTEGDVESGELRWPPEEFLVQEEEEEESCEDAKEDNKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SNF4</accession>
    <name>A0A8C2SNF4_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Calmodulin 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">CALM1</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the calmodulin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SNF4"/>
    <dbReference type="SMR" id="A0A8C2SNF4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005000655.1">
        <property type="protein sequence ID" value="ENSCJPP00005000347.1"/>
        <property type="gene ID" value="ENSCJPG00005000372.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182980"/>
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        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034704">
        <property type="term" value="C:calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902494">
        <property type="term" value="C:catalytic complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043209">
        <property type="term" value="C:myelin sheath"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099523">
        <property type="term" value="C:presynaptic cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030017">
        <property type="term" value="C:sarcomere"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097225">
        <property type="term" value="C:sperm midpiece"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031982">
        <property type="term" value="C:vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010856">
        <property type="term" value="F:adenylate cyclase activator activity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019855">
        <property type="term" value="F:calcium channel inhibitor activity"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0048306">
        <property type="term" value="F:calcium-dependent protein binding"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:protein kinase binding"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:protein phosphatase activator activity"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031432">
        <property type="term" value="F:titin binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="F:transmembrane transporter binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016240">
        <property type="term" value="P:autophagosome membrane docking"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097720">
        <property type="term" value="P:calcineurin-mediated signaling"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:cell surface receptor signaling pathway via JAK-STAT"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035458">
        <property type="term" value="P:cellular response to interferon-beta"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0071346">
        <property type="term" value="P:cellular response to type II interferon"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005513">
        <property type="term" value="P:detection of calcium ion"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:negative regulation of calcium ion export across plasma membrane"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:presynaptic endocytosis"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:regulation of cardiac muscle cell action potential"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010881">
        <property type="term" value="P:regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901844">
        <property type="term" value="P:regulation of cell communication by electrical coupling involved in cardiac conduction"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032465">
        <property type="term" value="P:regulation of cytokinesis"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002027">
        <property type="term" value="P:regulation of heart rate"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Calmodulin A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
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        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
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        <property type="match status" value="1"/>
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        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="4"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="40"/>
            <end position="75"/>
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    </feature>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005000347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="145" mass="16379" checksum="FABDD09FFB09FC44" modified="2022-01-19" version="1">MGLFLPLEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SPV6</accession>
    <name>A0A8C2SPV6_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sorbitol dehydrogenase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Polyol dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">SORD</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Cilium</location>
            <location evidence="2">Flagellum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SPV6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005001396.1">
        <property type="protein sequence ID" value="ENSCJPP00005000800.1"/>
        <property type="gene ID" value="ENSCJPG00005000864.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00550000074781"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070062">
        <property type="term" value="C:extracellular exosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046370">
        <property type="term" value="P:fructose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051160">
        <property type="term" value="P:xylitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000068">
        <property type="entry name" value="Sorbitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF9">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="6" id="KW-0282">Flagellum</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="13">
        <location>
            <begin position="16"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00026132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005000800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="356" mass="38062" checksum="C066BF133BE0BC45" modified="2022-01-19" version="1">MAELGQNLAVVVHRAGDLRLVRAGGAGPEGAGEVLLRMHSVGICGSDVHYWQHGRIGDFVVKNPMVLGHEASGTVIKVGAGVTHLKPGDRVAIEPGVPRETDEFCKTGRYNLSPTIFFCATPPDDGNLCRYYKHSASYCYKLPDNVTFEEGALVEPLSVGIHACKRAGVTLGSRVFVSGSGPIGLVNVIVAKMMGATEVVVTDLSAPRLQTAKEVGADYTIQVKNETPQEVAAKVESLLGCMPDITLECTGVQACIQASIYATRSGGTLVLVGLGPEMVTVPIVNAAVREVDIRGIFRYCNTWPVAISLLASKRINIKPLVTHRFPLEKALEAFETTKRGEGVKVMLKCDPTNQNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SQ73</accession>
    <name>A0A8C2SQ73_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tubby-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TULP1</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the TUB family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SQ73"/>
    <dbReference type="Ensembl" id="ENSCJPT00005003779.1">
        <property type="protein sequence ID" value="ENSCJPP00005002111.1"/>
        <property type="gene ID" value="ENSCJPG00005002270.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158771"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043679">
        <property type="term" value="C:axon terminus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001917">
        <property type="term" value="C:photoreceptor inner segment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001750">
        <property type="term" value="C:photoreceptor outer segment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016358">
        <property type="term" value="P:dendrite development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050908">
        <property type="term" value="P:detection of light stimulus involved in visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042462">
        <property type="term" value="P:eye photoreceptor cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006910">
        <property type="term" value="P:phagocytosis, recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045494">
        <property type="term" value="P:photoreceptor cell maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050766">
        <property type="term" value="P:positive regulation of phagocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903546">
        <property type="term" value="P:protein localization to photoreceptor outer segment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060041">
        <property type="term" value="P:retina development in camera-type eye"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.90.10:FF:000001">
        <property type="entry name" value="Tubby-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.90.10">
        <property type="entry name" value="Tubby Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025659">
        <property type="entry name" value="Tubby-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000007">
        <property type="entry name" value="Tubby_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018066">
        <property type="entry name" value="Tubby_C_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16517">
        <property type="entry name" value="TUBBY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16517:SF12">
        <property type="entry name" value="TUBBY-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01167">
        <property type="entry name" value="Tub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01573">
        <property type="entry name" value="SUPERTUBBY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54518">
        <property type="entry name" value="Tubby C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01200">
        <property type="entry name" value="TUB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01201">
        <property type="entry name" value="TUB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubby C-terminal" evidence="6">
        <location>
            <begin position="126"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005002111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="371" mass="41653" checksum="FF6B5F525F60165F" modified="2022-01-19" version="1">DSKAKSSKSTKKEPTSVFHVNGEKEKKSKKKAATGSDEEDDSDASTKPIRSGKKKNPASLFQTGGDPPRERKTRKKAPKAAESEEETLETQQKNSNKKGKGKKSKKKEERPPSPVIEVDNLEKFVLSPAPQGVTIKCRVTRDKRGMDRGLYPTYYLHLDNDKKVFLLAGRKRKKSKTSNYLISIDPTDLSRGGENFIGKLRSNLMGTKFTVFDNGANPDRASADWSNVRQELSAVVYETNVLGFKGPRKMTVIIPGMNSDNERVPIRPRNDNDGLLMRWQNKNMDNIIELHNKAPVWNDETQSYVLNFHGRVTHASVKNFQIVHSSDPDYIVMQFGRVADDAFTMDYNYPMCAVQAFAIALSSFDGKLACE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SQ96</accession>
    <name>A0A8C2SQ96_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cyclin-dependent kinase 12</fullName>
            <ecNumber evidence="4">2.7.11.22</ecNumber>
            <ecNumber evidence="3">2.7.11.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Cell division protein kinase 12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">CDK12</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="4"/>
    <dbReference type="EC" id="2.7.11.23" evidence="3"/>
    <dbReference type="RefSeq" id="XP_015741317.1">
        <property type="nucleotide sequence ID" value="XM_015885831.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005003919.1">
        <property type="protein sequence ID" value="ENSCJPP00005002189.1"/>
        <property type="gene ID" value="ENSCJPG00005002353.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107325199"/>
    <dbReference type="KEGG" id="cjo:107325199"/>
    <dbReference type="CTD" id="51755"/>
    <dbReference type="GeneTree" id="ENSGT00940000157595"/>
    <dbReference type="OrthoDB" id="28397at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002944">
        <property type="term" value="C:cyclin K-CDK12 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008024">
        <property type="term" value="C:cyclin/CDK positive transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071391">
        <property type="term" value="P:cellular response to estrogen stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033147">
        <property type="term" value="P:negative regulation of intracellular estrogen receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000737">
        <property type="term" value="P:negative regulation of stem cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd07864">
        <property type="entry name" value="STKc_CDK12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000102">
        <property type="entry name" value="cyclin-dependent kinase 12 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000074">
        <property type="entry name" value="cyclin-dependent kinase 12 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF126">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="20">
        <location>
            <begin position="727"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="70"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1051"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1164"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1224"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1310"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1437"/>
            <end position="1479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="183"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="225"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="266"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="289"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="312"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="365"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="428"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="479"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="19">
        <location>
            <begin position="529"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="581"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="654"/>
            <end position="666"/>
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    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="19">
        <location>
            <begin position="670"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1071"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="1231"/>
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        </location>
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    <feature type="compositionally biased region" description="Pro residues" evidence="19">
        <location>
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        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
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        <location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
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    <feature type="binding site" evidence="18">
        <location>
            <position position="756"/>
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        <ligand>
            <name>ATP</name>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012409"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00040213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00041920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049280"/>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
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    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005002189.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1479" mass="162733" checksum="B79F2C79A384E92F" modified="2022-01-19" version="1">MPNQERHGGKKDGGGGGTSLHSSGSSNSKERHRVASRHKRHKSRHSKESPLAAQETAAPLGAVIKPLVEYDDISSDSDTFSDDLALKLDRRENEERKADRSERTQKHRHHQHKRIRELMKSKQAEKERKLEKSLEASSRSGSTKDRVSGSSKRLLESEEHPKAPSSKSSNKESRSAKAHKEKSRKDRELKSSHKERSKSHRKRDAPKSYKTIDSPKRKSRSPHRKWLDSPKLDDSPSGASYVQEYDLSPPRSHTSSTYDPYRKSPGGSSRRQSISPPYKEPVAYQSNTRSPSPYSRRQRSISPYNRRRSSSYERGSGSYSGRSPSPYSRRRSSSPFAAKRSVSRSPIARKSVKSRSRSPGYSRHSSSHSKKQRSGSRSRHSSISPTRLPLNSSLGAELSRKKKERAAAAAAAAKVDGKEAKGSPIFLSKKENSLAELKESGTESKKVIKTVRSEKSSSDTELVNLLCSNAETKAPAETTKTKAEENSERKHPVPVRDSKQPGTKDLKPVAVTEDLRSPKETDTAEKEIPPPLPSIKSPPPPLPTTTPPPPTPPLPPLPPSPAVPPLPPSQQTPVQVPPSVPTSLSSSSHPRTSTLSSQVNSQSSVQVSTKTQASVTAAIPHLKTSTLPPLPLPPILVGEDDLDSPKEILPPKPVKKDREQRPRHLLTDLPLPPELPGGDPSPPDSPEPKAATPPQQPFKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLDYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYSSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSSALDLLDHMLTLDPGKRCTAEQALQSDFLRDVDLSKMAPPDLPHWQDCHELWSKKRRRQRQSGIAVEEPPLSKVSRKETTSVTSTDTVKNNSSPVHPQPAQLKTEAGAGDAVAGLGEITQQLNQSELAVLLNLLQSQTDLSVPQMAQLLNVHSNPEMQQQLEALNQSINALTEATTQQQESQAAAAEEAIEEPPTEAQPPEEQVTPEAAGAQGDMQNVLAVLLSQLMKSQEPVLTLEESNGEKSSEQRGLRKTPTMHQEESTACPPRVLPPEKRPPEPPGPPPPPPPLSEADLSSAAPELNPAVTAALLQLFSQQEESLSHAEHQAARSADYGKSHSSRTYSTEGSDGGFGTEELNSGQTLLEPSAQSVGKSRTFLGSVSHLGETSSYQGMGSVQFPGDQDLRFTRVPVALHSVGQSFSKTEGSNNTLVHPEAKIQTYGELGAGTAASSGAGTGHSWGTPAQAAPYGKTYRGPGRVPSRGGRGRGVPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SQP2</accession>
    <name>A0A8C2SQP2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">TUBA1A</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 14">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SQP2"/>
    <dbReference type="SMR" id="A0A8C2SQP2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005002892.1">
        <property type="protein sequence ID" value="ENSCJPP00005001709.1"/>
        <property type="gene ID" value="ENSCJPG00005001756.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182825"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome LGE22C19W28_E50C23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005879">
        <property type="term" value="C:axonemal microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036464">
        <property type="term" value="C:cytoplasmic ribonucleoprotein granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031594">
        <property type="term" value="C:neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036126">
        <property type="term" value="C:sperm flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008344">
        <property type="term" value="P:adult locomotory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071277">
        <property type="term" value="P:cellular response to calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007098">
        <property type="term" value="P:centrosome cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021696">
        <property type="term" value="P:cerebellar cortex morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021987">
        <property type="term" value="P:cerebral cortex development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030317">
        <property type="term" value="P:flagellated sperm motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048853">
        <property type="term" value="P:forebrain morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010001">
        <property type="term" value="P:glial cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048873">
        <property type="term" value="P:homeostasis of number of cells within a tissue"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035641">
        <property type="term" value="P:locomotory exploration behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007613">
        <property type="term" value="P:memory"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046785">
        <property type="term" value="P:microtubule polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061744">
        <property type="term" value="P:motor behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051402">
        <property type="term" value="P:neuron apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001764">
        <property type="term" value="P:neuron migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140058">
        <property type="term" value="P:neuron projection arborization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072384">
        <property type="term" value="P:organelle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021859">
        <property type="term" value="P:pyramidal neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050807">
        <property type="term" value="P:regulation of synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902065">
        <property type="term" value="P:response to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009612">
        <property type="term" value="P:response to mechanical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034612">
        <property type="term" value="P:response to tumor necrosis factor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007224">
        <property type="term" value="P:smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001964">
        <property type="term" value="P:startle response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008542">
        <property type="term" value="P:visual learning"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000005">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000007">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11 14" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="16">
        <location>
            <begin position="14"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="17">
        <location>
            <begin position="213"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005001709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="416" mass="46297" checksum="BF1E2C9AC0754A68" modified="2022-01-19" version="1">MPSDKTIGGGDDSFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLDRIRKLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLIGQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDMAALEKDYEEVGVDSVEGEGEEEGEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SRF7</accession>
    <name>A0A8C2SRF7_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">T-cell surface glycoprotein CD8 alpha chain-like</fullName>
        </submittedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SRF7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005004901.1">
        <property type="protein sequence ID" value="ENSCJPP00005002627.1"/>
        <property type="gene ID" value="ENSCJPG00005002945.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156588"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045065">
        <property type="term" value="P:cytotoxic T cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002456">
        <property type="term" value="P:T cell mediated immunity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001514">
        <property type="entry name" value="CD8 alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015468">
        <property type="entry name" value="CD8_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10441">
        <property type="entry name" value="CD8 ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10441:SF2">
        <property type="entry name" value="T-CELL SURFACE GLYCOPROTEIN CD8 ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0391">Immunity</keyword>
    <keyword evidence="13" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0564">Palmitate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034708471" evidence="14">
        <location>
            <begin position="23"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="5"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005002627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="243" mass="27150" checksum="6DD6C28053A0FBD9" modified="2022-01-19" version="1">MAGSPALLLLLSLGLCCTGAQRQRDAVVVSFNRNMKHPQQGQRLELECRTSRTTWGASWVRMDNSGNLHFIVSSNSPYNTVFHEYKRISQRFEVSWRDSSPWLVVKSFTAQDQGIYFCITNVNQVLHFSSGQPAFFPGQQQLHPPRLHPAPLPVPSQPGPSPTLPMALLLCPSRLITQALLLLIQAPCPTAPFMVPALPKHRGDRTAQKHLSIPSAALRDESYKGHSQHLLLTAFHKEFQNIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SS49</accession>
    <name>A0A8C2SS49_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="28">Amino acid transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="29" type="primary">SLC1A1</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="29" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="29" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="23">Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate. Can also transport L-cysteine. Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport. Plays an important role in L-glutamate and L-aspartate reabsorption in renal tubuli. Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate. Contributes to glutathione biosynthesis and protection against oxidative stress via its role in L-glutamate and L-cysteine transport. Negatively regulated by ARL6IP5.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>D-aspartate(out) + K(+)(in) + 3 Na(+)(out) + H(+)(out) = D-aspartate(in) + K(+)(out) + 3 Na(+)(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:71379"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:29990"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>K(+)(in) + L-aspartate(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-aspartate(in) + 3 Na(+)(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:70851"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>K(+)(in) + L-cysteine(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-cysteine(in) + 3 Na(+)(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:82559"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>K(+)(in) + L-glutamate(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-glutamate(in) + 3 Na(+)(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:70699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Apical cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Early endosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Late endosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="28">Membrane</location>
            <topology evidence="28">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Recycling endosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="21">Synapse</location>
            <location evidence="21">Synaptosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="22">Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. SLC1A1 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015704408.1">
        <property type="nucleotide sequence ID" value="XM_015848922.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SS49"/>
    <dbReference type="Ensembl" id="ENSCJPT00005005334.1">
        <property type="protein sequence ID" value="ENSCJPP00005002915.1"/>
        <property type="gene ID" value="ENSCJPG00005003195.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107306100"/>
    <dbReference type="KEGG" id="cjo:107306100"/>
    <dbReference type="CTD" id="6505"/>
    <dbReference type="GeneTree" id="ENSGT00940000155397"/>
    <dbReference type="OrthoDB" id="5877963at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome Z"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098794">
        <property type="term" value="C:postsynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098685">
        <property type="term" value="C:Schaffer collateral - CA1 synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015108">
        <property type="term" value="F:chloride transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033229">
        <property type="term" value="F:cysteine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140010">
        <property type="term" value="F:D-aspartate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005314">
        <property type="term" value="F:high-affinity L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015183">
        <property type="term" value="F:L-aspartate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <sequence length="527" mass="57180" checksum="0A1265186AA9FB63" modified="2022-01-19" version="1">MVKAGRKGCSCPDFMRKNWLLLSTVAAVLLGIGVGVLVREYGKLSNLDKFYFSFPGEVLMRMLKLVILPLIISSMITGVAALDSSVSGKIGLRAVVYYFCTTVIAVILGIVLVVTIKPGVPQSADEIDRVGSTPEVSTVDAMLDLIRNMFPENLVQACFQQYKTKREKVEATTGVDKNSSTATEEPVTTATTAEVLENKTQEYKIVGMYSDGINVLGLIVFCLVFGMVIGNMGEKGQVLVDFFNALNEATMKIVQIIMWYMPIGIVFLIAGKIIEVEDWEIFRKLGLYMATVLTGLAIHSTIILPLIYLVIVRKNPFRFAMGMAQALLTALMISSSSATLPVTFRCAEEKNFIDKRITRFVLPVGATINMDGTALYEAVAAVFIAQLNDLELDVGQIVTISVTATAASIGAAGVPQAGLVTMVIVLSAVGLPAEDVTLIIAVDWLLDRFRTMVNVLGDAFGTGIVEKLSKKELEQMDVSSDVNIVNPFALETTILDNDEAETKKSYVNGGFAVDKSDTISFTQTSQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SSZ4</accession>
    <name>A0A8C2SSZ4_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Coenzyme Q10A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">COQ10A</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with coenzyme Q.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the COQ10 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SSZ4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005005969.1">
        <property type="protein sequence ID" value="ENSCJPP00005003344.1"/>
        <property type="gene ID" value="ENSCJPG00005003550.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160056"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome LGE22C19W28_E50C23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048039">
        <property type="term" value="F:ubiquinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07813">
        <property type="entry name" value="COQ10p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.530.20:FF:000114">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044996">
        <property type="entry name" value="COQ10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005031">
        <property type="entry name" value="COQ10_START"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12901:SF8">
        <property type="entry name" value="COENZYME Q-BINDING PROTEIN COQ10 HOMOLOG A, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12901">
        <property type="entry name" value="SPERM PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03364">
        <property type="entry name" value="Polyketide_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Coenzyme Q-binding protein COQ10 START" evidence="4">
        <location>
            <begin position="75"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005003344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="250" mass="27968" checksum="BBA8F33F90A66DE9" modified="2022-01-19" version="1">MVQQGKPTKSIGQIHRAAPLPSSLLYRHTALCSLVFSRPAISTEWDPHRAPTRSFLNLAGSLTNKRKEYSERRIIGYSMQEMYDIVSNVDDYKSFVPWCKKSVVVSKRTGHIKAQLEVGFPPVLERYTSIVTLVRPHLVKVTHMEPLWGAPVGAPIGIPYWSPYGNLYGNPYGIPYGSPYGNPYWSPYWESPMGAPIRAPVGISYWSPYGNPYGIPFWSPYWDPLLRTPIGAPMGAPMGSHFGAPIGIPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SVJ2</accession>
    <name>A0A8C2SVJ2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SH3 domain-binding glutamic acid-rich-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">SH3BGRL2</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the SH3BGR family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SVJ2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005007432.1">
        <property type="protein sequence ID" value="ENSCJPP00005004439.1"/>
        <property type="gene ID" value="ENSCJPG00005004399.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159157"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03030">
        <property type="entry name" value="GRX_SH3BGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000065">
        <property type="entry name" value="SH3 domain-binding glutamic acid-rich-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006993">
        <property type="entry name" value="Glut_rich_SH3-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051033">
        <property type="entry name" value="SH3BGR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12232">
        <property type="entry name" value="SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12232:SF4">
        <property type="entry name" value="SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04908">
        <property type="entry name" value="SH3BGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008142">
        <property type="entry name" value="SH3-bind_E-rich_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0729">SH3-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR008142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005004439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="106" mass="12189" checksum="67F79A8219EA4CAD" modified="2022-01-19" version="1">MVIRVFVASSSGSVAIKKRQQDVVRFLEANRIEFEEVDITMSEEKRQWMYKNIPEDRQPAQGNPLPPQIFSDDRYCGDYDGFFESKESNTVFSFLGLKPSLASKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SW14</accession>
    <name>A0A8C2SW14_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 20">Polypeptide N-acetylgalactosaminyltransferase</fullName>
            <ecNumber evidence="20">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Protein-UDP acetylgalactosaminyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">GALNT6</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = a 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23956"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:12788"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:53604"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:67138"/>
            <dbReference type="EC" id="2.4.1.41"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = a 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52424"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:67138"/>
            <dbReference type="ChEBI" id="CHEBI:87075"/>
            <dbReference type="EC" id="2.4.1.41"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 20">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 20">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 20">Golgi apparatus membrane</location>
            <topology evidence="2 20">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 20">Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="20"/>
    <dbReference type="RefSeq" id="XP_015742489.1">
        <property type="nucleotide sequence ID" value="XM_015887003.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032296986.1">
        <property type="nucleotide sequence ID" value="XM_032441095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SW14"/>
    <dbReference type="Ensembl" id="ENSCJPT00005007511.1">
        <property type="protein sequence ID" value="ENSCJPP00005004490.1"/>
        <property type="gene ID" value="ENSCJPG00005004445.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107325813"/>
    <dbReference type="KEGG" id="cjo:107325813"/>
    <dbReference type="CTD" id="11226"/>
    <dbReference type="GeneTree" id="ENSGT00940000160845"/>
    <dbReference type="OrthoDB" id="416652at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome LGE22C19W28_E50C23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004653">
        <property type="term" value="F:polypeptide N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23470">
        <property type="entry name" value="beta-trefoil_Ricin_GALNT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02510">
        <property type="entry name" value="pp-GalNAc-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000024">
        <property type="entry name" value="Polypeptide N-acetylgalactosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000039">
        <property type="entry name" value="Polypeptide N-acetylgalactosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045885">
        <property type="entry name" value="GalNAc-T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675:SF58">
        <property type="entry name" value="POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 20" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 20" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13 20" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 20" id="KW-0430">Lectin</keyword>
    <keyword evidence="17 20" id="KW-0464">Manganese</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Ricin B lectin" evidence="22">
        <location>
            <begin position="497"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="102"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="117"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00050905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00052209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU361242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="SMART" id="SM00458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005004490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="621" mass="70614" checksum="9752423539B5D845" modified="2022-01-19" version="1">MRLLRRRYSPLKVALVGAVFLLFLFILQRDVGAGDQREEPWLKNIVDGKDQVIDLMLGAVHNLRDSMPKLQIRAPVPPEEPPHGARSCPPGFYTAAELRPLLERPPQDPSGPGADGKAFKKEQWTAEESKEKERGYEKHCFNAFASDRISLQRALGPDSRPPECIDQKFKRCPPLPTTSVVIVFHNEAWSTLLRTVYSVLHASPAALLKEIILVDDASTDEYLKDELDRYVKQLQIVRVVRQAERKGLITARLLGASVASGEVLTFLDAHCECFHGWLEPLLSRIAEEPTAVVSPDITTIDLNTFEFSKPVQYGKQHSRGNFDWSLTFGWEVVPPRERQRRKDETVPIKSPTFAGGLFAISRSYFEHIGSYDDQMEIWGGENVEMSFRVWQCGGQLEIIPCSVVGHVFRSKSPHTFPKGTQVISRNQVRLAEVWMDDYKEIFYRRNQQAAQMAREKTYGDITERRRLRERLHCKNFTWYLQNVYPEMFVPDLNPTSYGAIKNSGTNSCLDVGENNHGGKPLIMYPCHGMGGNQYFEYTTQRDLRHNVGKQLCLRAGAGPVQLGECSFRGQPTRVPPDEEWELTQDHLIKNHASRMCLTARGKHPAMAPCDPSDPHQLWSFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SX98</accession>
    <name>A0A8C2SX98_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Ferrochelatase</fullName>
            <ecNumber evidence="14">4.98.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">FECH</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the ferrous insertion into protoporphyrin IX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>heme b + 2 H(+) = protoporphyrin IX + Fe(2+)</text>
            <dbReference type="Rhea" id="RHEA:22584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="4.98.1.1"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="13">
            <dbReference type="Rhea" id="RHEA:22586"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Porphyrin-containing compound metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the ferrochelatase family.</text>
    </comment>
    <dbReference type="EC" id="4.98.1.1" evidence="14"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2SX98"/>
    <dbReference type="Ensembl" id="ENSCJPT00005008205.1">
        <property type="protein sequence ID" value="ENSCJPP00005004982.1"/>
        <property type="gene ID" value="ENSCJPG00005004838.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000016258"/>
    <dbReference type="UniPathway" id="UPA00252">
        <property type="reaction ID" value="UER00325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome Z"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030350">
        <property type="term" value="F:iron-responsive element binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009589">
        <property type="term" value="P:detection of UV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030218">
        <property type="term" value="P:erythrocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006785">
        <property type="term" value="P:heme B biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060586">
        <property type="term" value="P:multicellular organismal-level iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046501">
        <property type="term" value="P:protoporphyrinogen IX metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046984">
        <property type="term" value="P:regulation of hemoglobin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034379">
        <property type="term" value="P:very-low-density lipoprotein particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00419">
        <property type="entry name" value="Ferrochelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03411">
        <property type="entry name" value="Ferrochelatase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1400:FF:000003">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1400">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00323">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001015">
        <property type="entry name" value="Ferrochelatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019772">
        <property type="entry name" value="Ferrochelatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033644">
        <property type="entry name" value="Ferrochelatase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033659">
        <property type="entry name" value="Ferrochelatase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00109">
        <property type="entry name" value="hemH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108">
        <property type="entry name" value="FERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108:SF1">
        <property type="entry name" value="FERROCHELATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00762">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53800">
        <property type="entry name" value="Chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00534">
        <property type="entry name" value="FERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="9 14" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7 14" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 14" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12 14" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="85"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005004982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="551" mass="60622" checksum="79D685310C8E2D31" modified="2022-01-19" version="1">MSKQCNQRCSTLIPAPISRRGAPAQCDAAMEEPARPPRPGAVSARSSARRPCVHIAALRSAGALRQNQLRVPGLQLRGIPVRPGAGDAGLGSHRAPIPVPGRHSGARGGSGGGPRCGRAPCPRVGGRGWAERSGRQRPAGPSEGMHAANMAAAGRAARPLVAGSTQLRVPLRWRGQVAAAAPSTKPQAEPETRKPKTGILMLNMGGPERLDDVHDFLLRLFLDRDLMTLPAQNKLAPFIAKRRTPRIQEQYSRIGGGSPIKKWTAVQGEGMVKLLDSMSPQTAPHKYYIGFRYVHPLTEEAIEEMEDDGIERAIAFTQYPQYSCSTTGSSLNAIYRYYNKKGKKPKMKWSIIDRWPTHPLLIQCFADHIQKELDLFPPDKRKDVVILFSAHSLPMSVVNRGDPYPQEVGATVQRVMEKLNHSNPYRLVWQSKVGPMPWLGPQTDETIKGLCQRGKKNMLLVPIAFTSDHIETLYELDIEYAQVLANECGVENIRRAESLNGNPLFSKALADLVCSHIQSNEICSKQLTLCCPLCVNPVCRETKAFFSNQQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SXE2</accession>
    <name>A0A8C2SXE2_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BAF chromatin remodeling complex subunit BCL7B</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BCL7 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SXE2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005006847.1">
        <property type="protein sequence ID" value="ENSCJPP00005003984.1"/>
        <property type="gene ID" value="ENSCJPG00005004050.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000002172"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016514">
        <property type="term" value="C:SWI/SNF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006804">
        <property type="entry name" value="BCL7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12767:SF5">
        <property type="entry name" value="B-CELL CLL_LYMPHOMA 7 PROTEIN FAMILY MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12767">
        <property type="entry name" value="BCL7 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04714">
        <property type="entry name" value="BCL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="56"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005003984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="88" mass="9927" checksum="8C600985A3DE20F9" modified="2022-01-19" version="1">MSGRSVRAETRSRAKDDIKKVMAAIERVRRWEKKWVTVGDTSLRIFKWVPVADSKEMRTATRAPCPTFTSSRWTAAPIPAPVPSRASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SYJ2</accession>
    <name>A0A8C2SYJ2_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">INSC spindle orientation adaptor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">INSC</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015719603.1">
        <property type="nucleotide sequence ID" value="XM_015864117.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015719604.1">
        <property type="nucleotide sequence ID" value="XM_015864118.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015719605.1">
        <property type="nucleotide sequence ID" value="XM_015864119.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015719606.1">
        <property type="nucleotide sequence ID" value="XM_015864120.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032300925.1">
        <property type="nucleotide sequence ID" value="XM_032445034.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032300926.1">
        <property type="nucleotide sequence ID" value="XM_032445035.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032300927.1">
        <property type="nucleotide sequence ID" value="XM_032445036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SYJ2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005008057.1">
        <property type="protein sequence ID" value="ENSCJPP00005004905.1"/>
        <property type="gene ID" value="ENSCJPG00005004754.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107314650"/>
    <dbReference type="KEGG" id="cjo:107314650"/>
    <dbReference type="CTD" id="387755"/>
    <dbReference type="GeneTree" id="ENSGT00390000001511"/>
    <dbReference type="OrthoDB" id="5796379at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045179">
        <property type="term" value="C:apical cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008093">
        <property type="term" value="F:cytoskeletal anchor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045176">
        <property type="term" value="P:apical protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008356">
        <property type="term" value="P:asymmetric cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009786">
        <property type="term" value="P:regulation of asymmetric cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031647">
        <property type="term" value="P:regulation of protein stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd21966">
        <property type="entry name" value="INSC_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.200.10">
        <property type="entry name" value="Inscuteable LGN-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045789">
        <property type="entry name" value="Insc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031938">
        <property type="entry name" value="INSC_LBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038205">
        <property type="entry name" value="INSC_LBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039921">
        <property type="entry name" value="Inscuteable"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21386">
        <property type="entry name" value="INSCUTEABLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21386:SF0">
        <property type="entry name" value="PROTEIN INSCUTEABLE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19427">
        <property type="entry name" value="Insc_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16748">
        <property type="entry name" value="INSC_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein inscuteable homologue LGN-binding" evidence="1">
        <location>
            <begin position="22"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Protein inscuteable homologue C-terminal" evidence="2">
        <location>
            <begin position="79"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005004905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="531" mass="59704" checksum="74B92E9FF735407E" modified="2022-01-19" version="1">MAFKGEDYLDSLPLPVQRMHLIQVDSVQRWMEDLKLMTDCECMCILQSKPISAEKDEQNELILSSQYSTSDNLQLLLKRAWIISTELTRIAQKLEKSRWQRVHSMTVRVNCHVRSMINEYNAFTRSLSEEMNELEKLLIDKCSEFTAFTERCIQIEDEQMLRSMKSCINETLTTIAQYFGQLIELVLTHEAQNLLRQIESSDSVYITESAINSLFGLTQEGTHLCRIIAKEGGVTALFKICRQDYFRRLYPQTLRTLASICCVEEGMHQLEKVDGILCLADILTDNTHSEATHAEAAAVIAQITSPHLTFTQHLSSFLENMEEIVTALVKLCQEASSGEVFLLASAALANITFFDTMACEMLLQLNAMKILLAACSDKRIVDTPYSRDQVVTILANMSVLDQCASEIIQGNGIQLLMEMLFERSSSGNSAEVAACERVQQKSAVTLARLSRDPEVADAAVKLSCIPRLIKLCRSPTERNNSDSVLVACLAALRRLAVMSPDGLEDSDFQQLVKPRLVDSFLLCTNMEESFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T245</accession>
    <name>A0A8C2T245_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T245"/>
    <dbReference type="Ensembl" id="ENSCJPT00005010557.1">
        <property type="protein sequence ID" value="ENSCJPP00005006756.1"/>
        <property type="gene ID" value="ENSCJPG00005006253.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156588"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045065">
        <property type="term" value="P:cytotoxic T cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002456">
        <property type="term" value="P:T cell mediated immunity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001514">
        <property type="entry name" value="CD8 alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015468">
        <property type="entry name" value="CD8_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10441">
        <property type="entry name" value="CD8 ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10441:SF2">
        <property type="entry name" value="T-CELL SURFACE GLYCOPROTEIN CD8 ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0391">Immunity</keyword>
    <keyword evidence="13" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0564">Palmitate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="10"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="214"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="233" mass="26150" checksum="DA22DB7D48B9EE35" modified="2022-01-19" version="1">MDLNMKHPQQGQRLELECWRNKTSWRVSWIRLDRDGNLHYILSSYGTNTTIFQGGERTSPRYEATWSENICRLVVKSFSTEDEGIYFCITNMNQVLHFSSGQPPFSQVSNSFTHLAYTQLPCPCLLNLAHRPHSPWPCFIPKPFHYTGTAPSHTGSLPSSSAHGTGPAQRQSSYKVPPCLGGLNKISSVLTLCIHTLLPSSHIKSFTQLLPHCQHPEQPGHHEGHLPAQPGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T2A1</accession>
    <name>A0A8C2T2A1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T2A1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005011465.1">
        <property type="protein sequence ID" value="ENSCJPP00005007382.1"/>
        <property type="gene ID" value="ENSCJPG00005006817.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182932"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050769">
        <property type="entry name" value="NAT_camello-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13947">
        <property type="entry name" value="GNAT FAMILY N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13947:SF60">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005007382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="126" mass="13975" checksum="BA75B4CC16ADC88A" modified="2022-01-19" version="1">DSNRGSVSLKPPSYGGFWVAEADGRVVGTVGVMPAGEGGLLVLKRMAVRKDYRGRGVAKALCRAVLDFARRRPGCAAVVLNTIMLQHDARALYERLGFRRQRRFVLPTVYGRVANCTVTTYRYELQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T2B9</accession>
    <name>A0A8C2T2B9_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Nucleobindin 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">NUCB2</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the nucleobindin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015719612.1">
        <property type="nucleotide sequence ID" value="XM_015864126.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T2B9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005011120.1">
        <property type="protein sequence ID" value="ENSCJPP00005007172.1"/>
        <property type="gene ID" value="ENSCJPG00005006615.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107314655"/>
    <dbReference type="KEGG" id="cjo:107314655"/>
    <dbReference type="CTD" id="4925"/>
    <dbReference type="GeneTree" id="ENSGT00390000001927"/>
    <dbReference type="OrthoDB" id="5982823at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070062">
        <property type="term" value="C:extracellular exosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005640">
        <property type="term" value="C:nuclear outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000045">
        <property type="entry name" value="Nucleobindin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057576">
        <property type="entry name" value="NUCB1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040250">
        <property type="entry name" value="Nucleobindin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19237">
        <property type="entry name" value="NUCLEOBINDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19237:SF22">
        <property type="entry name" value="NUCLEOBINDIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25434">
        <property type="entry name" value="NUCB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="11 18" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034169015" evidence="18">
        <location>
            <begin position="25"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="19">
        <location>
            <begin position="241"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="19">
        <location>
            <begin position="293"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="194"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="349"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="194"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="212"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="381"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005007172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="455" mass="53810" checksum="C6FB74420C381F6C" modified="2022-01-19" version="1">MKWRSLLPRQCILLIPFLLMALEAVPIDIDKTKVKGEGHVEGEKIENPDTGLYYDEYLRQVIDVLETDKHFREKLQTADIEEIKSGKLSRELDLVSHHVRTRLDELKRQEVARLRMLIKAKMDSVQDTGIDHQALLKQFEHLNHQNPDTFEPKDLDMLIKAATSDLENYDKTRHEEFKKYEMMKEHERREYLKTLDEEKRQREESKFEEMKKKHGDHPKVHHPGSKDQLKEVWEEADGLDPNEFDPKTFFKLHDVNNDHFLDEQELEALFTKELEKVYDPKNEEDDMVEMEEERLRMREHVMNEVDINKDRLVTLEEFLRATEKKEFLEPDSWETLDQQQLFTEDELKEFESHISQQEDELRKKAEELQKQKEELQRQHDQLQAQKQELQQVVKQMEQKKLQQANPPAGPAGELKFQPPGEHKIEEAPKQPAGGDQPLPPGHIQEPAAGTDQVHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T383</accession>
    <name>A0A8C2T383_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase M12B propeptide domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T383"/>
    <dbReference type="Ensembl" id="ENSCJPT00005010947.1">
        <property type="protein sequence ID" value="ENSCJPP00005007044.1"/>
        <property type="gene ID" value="ENSCJPG00005006498.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161067"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990913">
        <property type="term" value="C:sperm head plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008584">
        <property type="term" value="P:male gonad development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002870">
        <property type="entry name" value="Peptidase_M12B_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF120">
        <property type="entry name" value="DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01562">
        <property type="entry name" value="Pep_M12B_propep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M12B propeptide" evidence="2">
        <location>
            <begin position="264"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005007044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="411" mass="44529" checksum="3F15FEC34629F2FF" modified="2022-01-19" version="1">MEMGWGWDGMDGNGGGDGVWGWDGMDGMGWDGMGWGWGWDGMGMDGMGWRWDGWDGWDGGMGWGMGWGWGDGDGMGWDGMGWDGMDGMGWDGMGWDGWMGWGWGWGWGWGWGWDGMGWDGMGWDGMGWDGMGWDGDGMGMGMGWGWGGEWGWDGAGVRDGVVMGWGWGWGMGMGWKDGMGWDGMGWDGMGWGSGGRWIGSSSSEGVGWSLGGSWRVAGAHQAARVTRMGTGQCPAMGVMALILILCSGLSGASRVVYSEVMVPRQLEQRHRAGTQDNVAYLITAEGRYHVVHLTRVKNLVAKDLPVYTYGAGGELVTEFPYIQDNCFYDGFVEGSPGSVVALSTCYGIRGILQIGELRYQVEPLLNSSMFQHLIYRTAPDEGRVPPCQLPTEQPARIGWRNTPMAAGTASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T3H4</accession>
    <name>A0A8C2T3H4_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Adhesion G protein-coupled receptor B3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Brain-specific angiogenesis inhibitor 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">ADGRB3</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Receptor that plays a role in the regulation of synaptogenesis and dendritic spine formation at least partly via interaction with ELMO1 and RAC1 activity. Promotes myoblast fusion through ELMO/DOCK1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015714631.1">
        <property type="nucleotide sequence ID" value="XM_015859145.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005012248.1">
        <property type="protein sequence ID" value="ENSCJPP00005007998.1"/>
        <property type="gene ID" value="ENSCJPG00005007163.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107312075"/>
    <dbReference type="KEGG" id="cjo:107312075"/>
    <dbReference type="CTD" id="577"/>
    <dbReference type="GeneTree" id="ENSGT00940000155081"/>
    <dbReference type="OrthoDB" id="5989160at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0150053">
        <property type="term" value="C:cerebellar climbing fiber to Purkinje cell synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098839">
        <property type="term" value="C:postsynaptic density membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043083">
        <property type="term" value="C:synaptic cleft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099558">
        <property type="term" value="P:maintenance of synapse structure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061743">
        <property type="term" value="P:motor learning"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007520">
        <property type="term" value="P:myoblast fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016525">
        <property type="term" value="P:negative regulation of angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016322">
        <property type="term" value="P:neuron remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051965">
        <property type="term" value="P:positive regulation of synapse assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048814">
        <property type="term" value="P:regulation of dendrite morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090128">
        <property type="term" value="P:regulation of synapse maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905806">
        <property type="term" value="P:regulation of synapse pruning"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd15989">
        <property type="entry name" value="7tmB2_BAI3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.610:FF:000002">
        <property type="entry name" value="Adhesion G protein-coupled receptor B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000003">
        <property type="entry name" value="Adhesion G protein-coupled receptor B2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000004">
        <property type="entry name" value="Adhesion G protein-coupled receptor B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000012">
        <property type="entry name" value="Adhesion G protein-coupled receptor B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1240.10:FF:000002">
        <property type="entry name" value="Adhesion G protein-coupled receptor B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.220.50:FF:000004">
        <property type="entry name" value="Adhesion G protein-coupled receptor B3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.10">
        <property type="entry name" value="GPCR, family 2, extracellular hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043838">
        <property type="entry name" value="AGRB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032471">
        <property type="entry name" value="AGRL2-4_GAIN_subdom_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008077">
        <property type="entry name" value="GPCR_2_brain_angio_inhib"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036445">
        <property type="entry name" value="GPCR_2_extracell_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001879">
        <property type="entry name" value="GPCR_2_extracellular_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011:SF40">
        <property type="entry name" value="ADHESION G PROTEIN-COUPLED RECEPTOR B3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011">
        <property type="entry name" value="ADHESION G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19188">
        <property type="entry name" value="AGRB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16489">
        <property type="entry name" value="GAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02793">
        <property type="entry name" value="HRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01694">
        <property type="entry name" value="BAIPRECURSOR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00008">
        <property type="entry name" value="HormR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50227">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50221">
        <property type="entry name" value="GAIN_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="14" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="877"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="911"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="941"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="980"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1019"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1097"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 1" evidence="20">
        <location>
            <begin position="490"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="GAIN-B" evidence="19">
        <location>
            <begin position="692"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="21">
        <location>
            <begin position="875"/>
            <end position="1149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00056958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00070434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00082599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005007998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1520" mass="171103" checksum="F105E729A9B9511E" modified="2022-01-19" version="1">MKAVRNLLIYIFSTYLLVMFGFNAAQDFWCSTLVKGVIYGSYSVSEMFPKNFTNCTWTLENPDPTKYSIYLKFSKKDFSCSNFSLLAYQFDHFSHEKIKDLLKNNHSIMQLCDSKNAFVFLQYDKNFIQIRRVYPIDFLGLHKKEEDQKSFFEFLVLNKVSPSQFGCHVLCTWLESCLKSENGRTESCGIMYTKCTCPQHLGEWGIDDQSLVLLNNVVLPLNEQTEGCLTQELQTTQVCNLTREAKRPPKEEFGMMGDHTIKSQRPRSVHEKRVPQEQADAAKFMAQTGESGVEEWAQWSTCSVTCGQGSQVRTRTCVSPYGTHCSGPLRESRVCNNTALCPVHGVWEEWSPWSLCSFTCGRGQRTRTRSCIPPQYGGRSCDGPETQHKPCNIALCPVDGQWQEWSPWSQCSVTCSNGTQQRSRQCTAAAHGGSECRGPWAESRECYNPECTANGQWNQWGHWSGCSKSCDGGWERRIRICQGAAVTGQQCEGTGEEVRRCSEQRCPAPYEICPEDYLMSMVWKRTPAGDMAFNRCPLNATGTTSRRCSLSVHGVAFWEHPSFARCISNEYRHLQHSIKEHLAKGQRMLAGDGMSQVTKTLLDLTQRKNFYAGDLLISVEILRNVTDTFKRASYIPASDGVQNFFQIISNLLDEENKEKWEDAQQIYPGSVELMQVIEDFIHIVGMGMMDFQNSYLMTGNVVASIQKLPAASVLTDINFPMKGRKGMVDWARNSEDRVVIPKNIFTPMSTELDESTVFVLGAVLYKNLELILPTLRNFTVVNSKIIVVTIRPEPKTADSFLEIELAHLSNGTLNPYCVLWDDSRTNDSLGTWSTQGCKTVLTDASHTKCLCDRLSTFAILAQQPREIIMESSGTPSVTLIVGSGLSCLALVTLAVVYAALWRYIRSERSIILINFCLSIISSNILILVGQTQTHNKGICTTTTAFLHFFFLASFCWVLTEAWQSYMAVTGKIRTRLIRKRFLCLGWGLPALVVAISIGFTKTKGYGTAHYCWLSLEGGLLYAFVGPAAAVVLVNMVIGILVFNKLVSRDGILDKKLKHRAGQMSEPHSGLTLKCAKCGVVSTTALSATTASNAMASLWSSCVVLPLLALTWMSAVLAMTDKRSILFQILFAVFDSLEGFVIVMVHCILRREVQDAFRCRLRNCQDPINADSSSSFPNGHAQIMTDFEKDVDIACRSVLHKDIGPCRAATITGTLSRISLNDEEEEKGPNPEGMSYSTLPGNIISKVIIQQPTGLHMPMSMSELANQCLKKDNSELRRTVYLCTDDNLRGADMDIVHPQERMIESDYIVMPRSSVNTQPSLKDESKINIGMDTLPHERLLHYKVNPEFNMNPSVMDQFNINLDQHLPTQEHMQSLPFEPRTAVKNFIASELDDNAGLSRSETGSTISMSSLERRKSRYSDLDFEKVMHTRKRHMELFQELNQKFQTLDRFRDVPKSGSMENSAPNKVPWDNFKTTGDYQHYTTINVLDTEAKDTLELRPAEWEKCLNLPLDVQEGDFQTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T3R4</accession>
    <name>A0A8C2T3R4_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transmembrane protein 189-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC107323104</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fatty acid desaturase CarF family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T3R4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005012377.1">
        <property type="protein sequence ID" value="ENSCJPP00005008103.1"/>
        <property type="gene ID" value="ENSCJPG00005007309.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163703"/>
    <dbReference type="UniPathway" id="UPA00199"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050207">
        <property type="term" value="F:plasmanylethanolamine desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008611">
        <property type="term" value="P:ether lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019547">
        <property type="entry name" value="Lipid_desat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052601">
        <property type="entry name" value="Plasmalogen_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48177:SF1">
        <property type="entry name" value="PLASMANYLETHANOLAMINE DESATURASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48177">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10520">
        <property type="entry name" value="Lipid_desat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Lipid desaturase" evidence="8">
        <location>
            <begin position="213"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="11"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="82"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005008103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="398" mass="45100" checksum="61233C0E3FC9D568" modified="2022-01-19" version="1">MWTCGHEAMRTRCHADTSTRTHTPCPHGARSRGSCSRGASSCVPAPPAPPLAAPAARSHWPLPLATRSHWPVALWACPAVPSPRPLPRPAPGSRFPMRFRSVQLPPPAGSEQERPGPEPLGRAMERSRPEREEAAGPDGEASEEPESGGRRWGAQHAGARELAELYSPGKRLQEWISVILCFSLICFNFYNLLFYLRLEHTPSIIVGIFAGVITADFLSGLFHWGADTWGSVELPIVGKAFIRPFREHHIDPTAITRHDFIETNGDNCFMTLVPLANMAYKFVSFSPEALYETCPWECYVFALIIFITMTNQIHKWSHTYFGLPRWVIFLQDWHVILPRKHHRIHHVSPHETYFCITTGWLNYPLEKIGFWRCLENMIQGLTGEKPRADDMKWAQKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T4P7</accession>
    <name>A0A8C2T4P7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005011497.1">
        <property type="protein sequence ID" value="ENSCJPP00005007408.1"/>
        <property type="gene ID" value="ENSCJPG00005006835.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000164079"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="CDD" id="cd14618">
        <property type="entry name" value="R-PTPc-V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000369">
        <property type="entry name" value="Protein tyrosine phosphatase, receptor type B"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000009">
        <property type="entry name" value="Receptor-type tyrosine-protein phosphatase beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041201">
        <property type="entry name" value="PTPRJ_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050713">
        <property type="entry name" value="RTP_Phos/Ushers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957:SF10">
        <property type="entry name" value="PROTEIN TYROSINE PHOSPHATASE, RECEPTOR TYPE, H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18861">
        <property type="entry name" value="PTP_tm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 14" id="KW-0732">Signal</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034546228" description="protein-tyrosine-phosphatase" evidence="14">
        <location>
            <begin position="22"/>
            <end position="2267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1638"/>
            <end position="1659"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="45"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="136"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="226"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="315"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="493"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="762"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="943"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="1124"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="1306"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="1393"/>
            <end position="1486"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="15">
        <location>
            <begin position="1708"/>
            <end position="1967"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="16">
        <location>
            <begin position="1885"/>
            <end position="1958"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="15">
        <location>
            <begin position="2005"/>
            <end position="2262"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="16">
        <location>
            <begin position="2180"/>
            <end position="2253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005007408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="2267" mass="247336" checksum="F484648F41E988C8" modified="2022-01-19" version="1">MRPPLLPLLVLWVPRFLGTLAEEEGCNGTAWAGLEARDVLGDRGLILNISASNQGRLGSLFLSWDEPEGAVEGYSLTLSPLGSGTLLQNGSVGPNITNFWFHGLTPGTYYEIEVTATLRCMDTARQTVTAQTSPSPVRNLSLSSSGSPTSLHASWAAGSGQWDGYQLTLYHSDSQMLVRNASVPPNTTTFLFDGLAAGSEYALKVSTLAGASQASTSTHQWTAPSIPTQLKLSPSSSTSLSATWVSAGGAAWLHLVLRNLHTQTVTKTLSAKRGLTSYSFQHLQPGTQYWLGLSAVAGPYTMDGPNATAWTYPLSPTNVTLSGAEEQSSLQAQWIIPAGQRDFYLVTLREVEGGAPTRNISIGGDNGRVAFHGLSPGKQYSVQVTAVAGPYRASARSVAAWTQPLPPSALSLSSHGSPSSLRASWEEAMGEGYMVALSPTELPVKNSSLLRGATNVTYEGLHPGTLYTFEVSTVAGPYTSVPQRITNWTYPLPLEQLTLSNQGCSTSLQAAWRAAPAGSTGYTGTLWESRSQEWVRNVSVGNNWTNVTFEDLVPGRQYTLEMAAMAGPYRSSMRSATDWTYPLAPSGVTLTNTRRPLGLSAFWEKAAGDVDQFHLQLYSKSHPMQRNISVGPNIHNFTFLGLTPGVQYFLKVSVLAGPYRSSSHFATEWTYPLSLANVSVQPGRRPQELHVSWVESGGGREHLVQLLVAESIIRNVSVPHGVTHLDLEGLVPGSQYQVEIISQAGPHRISSQTAIGYTVPLPPLSLSTSPVGTAWALAVHWETPPGQRDGYLLSVLEEGSSSPARNLEVGKDSTNVTLTQLTPGSCYLVGIWAVAGAFRSLPRNTTGCTVPAAPTNLSLTNPGSSSELHTWWNKPLGRRDHYRVVLHSLTQSRDRVQTVSQDTQNIIWTHLEAGSRFAVQVIAVKGSLEASSANVTQWTYPLAPTNLTLRSPSASALRASWAAMGRGAESYVAELYDTASSHRVGHAVLGGGARSHIFHSLNPGTLYSVAVRATAGPYHTSTSNLTHCTRPLPPTAVRLLNTGHSDRLSASWGAAAGGQDGYMLTLYHTGLGTTAATASAGRDTHNVTFMGLAPGYKYSLEVSATAGPYQTAAPNVSGWTSPLPPTAVRLLNTGHPNRLSASWRAAAGGHDGYMLTLYHTRLGTTAATASAGRDTHNVTFTGLAPGSKYSLEVASIAGSYQTPAGNVSNWTYPLAPRNVYMTNQGYPNRLSVSWRAEPQGHDGYRLLLYHSGSGVLAASTYVGKGISKFTFSGLDPGHKYLLEVVSVAGPYAASAGNISDWTTPSVPHNLSVVVEGNSTVLISWGSAPGQQDDCQLWLRDPRNGSLPRQHALTKGQFQHLLHGLTPGRNYSVSLSCVAGPYWSSTKPLAVAMEPNPVEDVHCLPESRSLFVNWSGSPGDVEAYEVVTEGLSDDPPTPKHSVSVPMSQASLEGLQPNSSYRIAVSTVGINAMKSLAVTLLCNTTAEALPPPLRAEVFQIEASSTVIISSDLFSEENGQIEYYGVVATTNDSLLRPTQDIMSSTWYDHYYGTEDSYLAVLIPNPFHPSSTRSPETWRVPMGTEECSQTRAMCNGKLKANEQYRFSIAAFTKYDPVTPAVSFTTFSAAGDSMNTAPLPVPIIAGIVVGFLLTLTAIFALVYWKQLRARRTQKSSLPQEMVTYSLRNVHRPVPIQNFKQYYEMKTASGNQAFFQEFEELKEVGKEQLKVGAELPANISKNRYPHVLPYDHSRVRLSQLGDDLHSDYINANFVPGYTSPQEFIVTQGPLKKTIEDFWRLVWEQNVCNIIMLTVCMENGRVLCDHYWPSEAAPVSYGQVQVHLLSHSSAEEWTMREFKLWHEGLRAERHVSHLHYTAWPDHGIPESTTSILAFRELVREHIQSAKDAGPTLVHCSAGVGRSGTFIALDQLLQQMKQEKVVDMFGVVYTLRMNRYQMIQTLSQYIFLHSCILDKILEEPLLGLSGTETSCPIPLKSFAQHYSQNSAKSNMGFLREYETLLEVAKEETSSATPSLGTQQARPSSSILPYDRSRVKFSLLDQGPFSGLQVWRVPGCSSSRDYLAVQGPDKLTVEDFWMLVWEQDIHTILTLLPWQEVGEVPHDTCWPLEGDSVCTKLLTIQCGTEKTASGWRCIQLKVKHEKKGKEKQVQQFLYRLWSSKEQPNVQSLVELLTAIRRCVPNRKRASPLLLHCSGGENQMGTLIALDCLLHQLKTERTVDVYGVTLQLMRSCCFMTPTLDQYMFLYTCIRDITQKQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T6E5</accession>
    <name>A0A8C2T6E5_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TNFR-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T6E5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005012520.1">
        <property type="protein sequence ID" value="ENSCJPP00005008212.1"/>
        <property type="gene ID" value="ENSCJPG00005007392.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00960000190049"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042127">
        <property type="term" value="P:regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001368">
        <property type="entry name" value="TNFR/NGFR_Cys_rich_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47139">
        <property type="entry name" value="TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47139:SF1">
        <property type="entry name" value="TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00020">
        <property type="entry name" value="TNFR_c6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00208">
        <property type="entry name" value="TNFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57586">
        <property type="entry name" value="TNF receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00652">
        <property type="entry name" value="TNFR_NGFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50050">
        <property type="entry name" value="TNFR_NGFR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="TNFR-Cys" evidence="1">
        <location>
            <begin position="24"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="3">
        <location>
            <begin position="24"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="78"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="90"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="117"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005008212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="132" mass="14232" checksum="BCB71F7B8ABB4C70" modified="2022-01-19" version="1">HSLCSAGNIGTFVSGCGRAPLCQHCPADTFSLAGSRSCDLCRKCEGRFTYLKACSPVSDAVCTCKEGYRCSDSGCSRCDRSCGPGKERTGSAQTTPEQSVQEETCSCRFPEEEQGEDRDCGKSTEFRNLLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T8C8</accession>
    <name>A0A8C2T8C8_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Large ribosomal subunit protein mL44</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">39S ribosomal protein L44, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">MRPL44</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the 39S subunit of mitochondrial ribosome. May have a function in the assembly/stability of nascent mitochondrial polypeptides exiting the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ribonuclease III family. Mitochondrion-specific ribosomal protein mL44 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T8C8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005013736.1">
        <property type="protein sequence ID" value="ENSCJPP00005009170.1"/>
        <property type="gene ID" value="ENSCJPG00005008104.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000016956"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070877">
        <property type="term" value="C:microprocessor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19874">
        <property type="entry name" value="DSRM_MRPL44"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_mL44_DSRM_metazoa"/>
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        <property type="entry name" value="RM44_endonuclase"/>
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        <property type="entry name" value="RNase_III_sf"/>
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    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
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            <end position="254"/>
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    <sequence length="384" mass="42476" checksum="841FE57029AA1119" modified="2022-01-19" version="1">MWGCLAWCAVELRCEAHPDGQTDGPVTPSLPVRSVPLPLGAFPSGGRVIGRTFPSRPAAMSAVLLLLRGSRRLLPAAGTGRVAPGSAPRRDKKRWVRAYLEMQRLREAPRRRSERPGWDYHAEIQAFGHRLQENFSLELLKTAFVNSCYIKSEEAKRRDLGVDKDAVALNLRDNAELSARGMEFARSYLTRSFEAAHPRLPAPGVAALVSFLTGQQLVSYVAHNLALHDLVLCEEFPAPPAVLHNTFFAVVGALLGSSGTERAGLFVRDFLIPQLIGKDLFEIWEVVNPMGLLVEELAKRNIAAPEPRITRQLGVSTVLPLYFIGLYCDKKLIAEGPGETLLAAEEEAARVALRKLYGYTENRRPWDYSNPKEGWTAEKAISSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T8U7</accession>
    <name>A0A8C2T8U7_COTJA</name>
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        <submittedName>
            <fullName evidence="15">CUB and Sushi multiple domains 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">CSMD1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the CSMD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSCJPT00005013767.1">
        <property type="protein sequence ID" value="ENSCJPP00005009198.1"/>
        <property type="gene ID" value="ENSCJPG00005008081.1"/>
    </dbReference>
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        <property type="component" value="Chromosome 3"/>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="P:conditioned place preference"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:female gonad development"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042593">
        <property type="term" value="P:glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:male gonad development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007613">
        <property type="term" value="P:memory"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001964">
        <property type="term" value="P:startle response"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="match status" value="28"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="13"/>
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    </dbReference>
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        <property type="entry name" value="Complement Module, domain 1"/>
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    </dbReference>
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        <property type="entry name" value="Spermadhesin, CUB domain"/>
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    <dbReference type="InterPro" id="IPR051277">
        <property type="entry name" value="SEZ6_CSMD_C4BPB_Regulators"/>
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        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN CBR-CLEC-78"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="14"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="28"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 11" id="KW-0768">Sushi</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
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    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="1315"/>
            <end position="1342"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="2684"/>
            <end position="2711"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="2742"/>
            <end position="2769"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="2800"/>
            <end position="2827"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="2863"/>
            <end position="2890"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="2921"/>
            <end position="2948"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="2982"/>
            <end position="3009"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="3041"/>
            <end position="3068"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="3159"/>
            <end position="3186"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="3217"/>
            <end position="3244"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="3279"/>
            <end position="3306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005009198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="3601" mass="394954" checksum="D737138963CD2315" modified="2022-01-19" version="1">MYKPGRQKYLLSQNCGGLVQGPNGTIESPGFPHGYPNYANCTWIIITGERNRIQLSFHTFALEEDFDILSIYDGQPQQGNLKVRLSGFQLPSSIVSTGSILTLCFTTDFAVSAQGFKAIYEVLPSHTCGNPGEIPKGVLHGTRFNIGDKIRYSCISGYILEGHAMLTCIVSPGNGASWDFPVPFCRAEGACGGTLRGTSGTISSPHFPSEYENNADCTWTILAEPGDTIALIFTDFQLEEGYDFLEISGTEAPSIWLTGMNLPSPVISSKNWLRLHFTSDSNHRRKGFNAHIYIFVKVHLNYQRQYRYFSLFYLDIAFLLLQYLIWLRHFLPTRFNNKLFSFSLLVFSVKKAIELKSRGVKMLPNKDSNHKNSVLTQGGDAVASDTCPDPGIPENGKRVGSDFRVGASVQFSCEDNYVLQGSKSITCQRVTDTLAAWSDHRPICRARTCGSNLRGPSGIITSPNYPVQYEDNAHCVWVITTVDPEKVIKLAFEEFELERGYDTLTVGDAGKVGDTRTVLYVLTGSSVPDLIVSMSNQMWLHLQSDDSIGSPGFKAVYQEIEKGGCGDPGIPSYGKRTGSSFLHGDTLTFECQAAFELVGERTITCQQNNQWSGNKPSCVFSCFFNFTTPSGIILSPNYPEEYGNNMNCVWLIISEPGSRIHLIFNDFDVEPQFDYLTVKDDGISDLPPLGTFSGNEVPSQLASSGHIVRLEFQSDHSTTGRGFNITYTTFGQNECHDPGIPINGRRFGDRFLLGSSVSFHCDDGFVKTQGSESITCIMQDGNVVWSSTVPRCEAPCGGHLTASSGVILPPGWPGYYKDSLNCEWVIEARPGHSIKITFDRFQTEVNYDTLEVRDGPANSSPLIGEYHGTQAPQFLISTGNYMYLLFTTDNSRSSVGFLIHYESVTLESDSCLDPGIPVNGHRHGNNFNIRSTVTFSCDPGYTLSDEEPLICERNHQWNHALPSCDALCGGYIQGRSGTILSPGFPDFYPNSLNCTWTIEVSHGKGVQLLFHTFHLESSHDYLLITEDGSFTEPVARLTGSVLPPTIKAGLFGNFTAQLRFISDFSISYEGFNITFSEYDLEPCDDPGVPAFSRRIGFQFGVGDSLIFSCFPGYRLEGANKLTCLGGGRRVWSAPLPRCVAECGATVSGNEGTLLSPNFPSNYDNNHECIYKIETEAGKGIHLRARSFQLHEGDIVKVYDGKDSSSRSLGAFTKNEMMGVILNSTSNHLWIEFNTNGSETDQGFQLTYTSFDLVKCEDPGIPNYGYKIRDEGHFVDTVILYSCNPGYTMHGSGIMTCLSGDRRVWDKPLPTCIAECGGRIHAATSGRILSPGYPAPYDNNLHCTWVVEADPGKTISLHFIVFDTEVAHDILKVWDGPIESNILLKEWSGSSLPEDIHSTFNSLTLQFDSDFFISKSGFSIQFSTSIASTCNDPGTPQNGTRYGDSREPGDTTTFQCDPGYQLQGQAKITCVQLNNRFFWQPDPPTCIAACGGNLTGPAGVILSPNYPQPYPPGKECDWRIKVNPDFVIALIFKSFNMEPSYDFLHIYEGEDSNSPLIGSFQGSQAPERIESSGNSLFLAFRSDASVGMSGFAIDYKEKPREACFDPGNIMNGTRTGTDFKLGSTITYQCDSGYKIVDPSTITCVIGADGKPAWNRALPSCNAPCGGQYTGSEGVVLSPSYPHNYTAGQTCHYSITVPKEFVVFGQFAYFQTALNDVAELFDGDNSQSRLLSSLSGSHSGETLPLATSNQILLRFSAKSGASARGFHFVYQAVPRTSDTQCSSVPEPRYGRRIGSEFSAGSVVRFECSPGYLLQGSKAIRCHSVPNALAQWNDTVPSCVVPCSGNFTERRGTILSPGYPEPYGNSLNCVWKIIVTEGSGIQIQVISFATEHNWDSLEIYDGGDMTAPRLGSFSGTTVPALLNSTSNQLYLHFYSDISVSAAGFHLEYKTVGLTACPEPVIPSNGIKSGDRYMVNDVLSFQCEPGYTLQGRSHISCMPGTVRRWNYPSPLCIAKCGGTLTNMGGVILSPGFPGNYPSNLDCTWKILLPIGYGAHIQFLNFSTEANHDFLEIQNGPYHTSSMIGQFSGMELPSPLLSTTHETLVHFYSDHSENRQGFKLTYQAYELQNCPDPPPFLNGYIVNSDYSVGQSVSFECYPGYVLRGQPVLTCQHGINRNWNYRFPRCEAPCGYNVSAQNGTVYSPGFPDEYPNSKDCTWLIVVPPGHGIYINFTLLQTEPVNDYIAVWDGPDHNSPQLGVFSGNTALETAYSSTNQVLLKFHSDFSTGGFFVLNFHAYQLKKCQPPPIVPHADLFTEDDDFGIGDFVKYKCQPGFTLVGQDILTCKLNTQLQFEGSSPISQCPANEIRTESSGVILSPGYPGTYPNSQTCSWTIKVDPGYNISIFVEMFQSEKQFDELEVFDGSSGQSPLLVALSGNHTGQLNFTSKMNQLYLRWSTDHATSKKGFKIRYSAPYCSLNPTLRNGGIVNKTGGPAGSKVHYYCKPGYRMIGQNNATCRRHQNGMYQWDSPVPICRAVSCGIPDSPGNGSVIGNEFTLGSRLIYECNEGFKLESSQQATAVCQEDGLWSNKGRPPVCKSVTCPNIETLLSEHVVWRLISGSLNEYGAQVMLSCSPGYYLLGRRLIQCRTNGTWSVGNERPICKVISCGGLPSPPNGNKIGTLTVYGATAIFTCNTGYTLVGSHVRECLANGLWSGAETQCLAGHCGSPDPIVNGHISGDGFSYRDTVVYQCNPGFRLVGTSVRICLQDHRWSGQTPVCVPITCGHPGNPAHGMTNGSEFNLNDVVNFTCNTGYLLQGASQAQCRSNGQWSSPLPNCRVVNCSDPGFVENAIRHGQQNYPESFKFGTSVAYHCKKGFYLLGSSALTCKSNGLWDRSLPKCLSISCGHPGVPANAVLSGDKFTYGSVIHYSCTAGRRLIGNSTRECQEDSHWSGTLPHCSGNNPGYCDDPGIPAHGSRLGDEFKIKSLLRFSCEMGYQLRGSSERTCLLNGSWSGIQPVCEAVSCGNPGTPANGMIVYSDGILFSSSVIYACWEGYKTSGLTTRHCTANGTWTGTAPDCTVISCGDPGALANGIQFGNDFTFNKTVRYQCNPGYVMEPASSSTMRCIKDSTWNQSKPICKAITCGPPPPVLYGKVEGSDYRWGASVSYSCAEGYQLSNTAILSCEGQGIWRGDIPQCLPVFCGDPGTPAEGRLNGKSFTYRSEVSFQCRPPFILIGSSRRFCQADGTWSGIQPTCIDPAHNTCTDPGTPHFGIQNSSRGYEVGSTVFFRCRKGYHIQGSTTRSCLANLTWSGIQSECIPHACRQPETPAHVDVKAIDLPTLGYTLVYTCQPGFFLAGGSEHRTCKPDMKWTGKSPICKSKSLLCDMLCPIWMNFIFPDIYVFFVNSLWKGFYEYLGKRQPATLTIDWFNTTSSKVNATFTEASSLQIKLSGVYKKEEAHLLLKIFQIKGSNDIFINKFENGNWALDGYVRLERGVFTYQGDIHGKDFGKFMLQRQGPLSADTDLSNHYYGTNSSSVAAAILVPFFALILSGFAFYLYKHRTRPKVQYNGYAGHENSNGQASFENPMYDTNLKPTEAKAVRFDTTLNTVCTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T941</accession>
    <name>A0A8C2T941_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T941"/>
    <dbReference type="Ensembl" id="ENSCJPT00005013584.1">
        <property type="protein sequence ID" value="ENSCJPP00005009059.1"/>
        <property type="gene ID" value="ENSCJPG00005008017.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005009059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="213" mass="23974" checksum="20F556AAE31189D0" modified="2022-01-19" version="1">MIFTGCHCSLLHPQCPHKACHHTRLQHTGDITLARTGVPDSTSPPIAEWHRGGGCVHQSPWCCAHILHTATLGPPSLAGGAPATAWTFWWWFKDCRWRKLLLQPLHWKGLCWVCRRWCSSSSVWRGKLDFSLKLFPQAGHWKGRSPVCRRWSEWVWNWCPQALGEEACAQRADAGHQKQHPSGRSCSCMARGPGLGFPRTVRAIRLMSATPGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TA13</accession>
    <name>A0A8C2TA13_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kinetochore protein NDC80</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">NDC80</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the NDC80 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Chromosome</location>
            <location evidence="10">Centromere</location>
            <location evidence="10">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the NDC80/HEC1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015710851.1">
        <property type="nucleotide sequence ID" value="XM_015855365.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015710852.1">
        <property type="nucleotide sequence ID" value="XM_015855366.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TA13"/>
    <dbReference type="Ensembl" id="ENSCJPT00005015711.1">
        <property type="protein sequence ID" value="ENSCJPP00005010639.1"/>
        <property type="gene ID" value="ENSCJPG00005009037.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107310055"/>
    <dbReference type="KEGG" id="cjo:107310055"/>
    <dbReference type="CTD" id="10403"/>
    <dbReference type="GeneTree" id="ENSGT00390000018386"/>
    <dbReference type="OrthoDB" id="7459479at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140483">
        <property type="term" value="F:kinetochore adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051298">
        <property type="term" value="P:centrosome duplication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008315">
        <property type="term" value="P:G2/MI transition of meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051383">
        <property type="term" value="P:kinetochore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090267">
        <property type="term" value="P:positive regulation of mitotic cell cycle spindle assembly checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031647">
        <property type="term" value="P:regulation of protein stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014841">
        <property type="term" value="P:skeletal muscle satellite cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007057">
        <property type="term" value="P:spindle assembly involved in female meiosis I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.30:FF:000002">
        <property type="entry name" value="NDC80, kinetochore complex component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.30">
        <property type="entry name" value="Ncd80 complex, Ncd80 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040967">
        <property type="entry name" value="DUF5595"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005550">
        <property type="entry name" value="Kinetochore_Ndc80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055260">
        <property type="entry name" value="Ndc80_CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057091">
        <property type="entry name" value="NDC80_loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038273">
        <property type="entry name" value="Ndc80_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10643">
        <property type="entry name" value="KINETOCHORE PROTEIN NDC80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10643:SF2">
        <property type="entry name" value="KINETOCHORE PROTEIN NDC80 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18077">
        <property type="entry name" value="DUF5595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03801">
        <property type="entry name" value="Ndc80_HEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24487">
        <property type="entry name" value="NDC80_loop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="9 10" id="KW-0137">Centromere</keyword>
    <keyword evidence="2 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 10" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="4 10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinetochore protein Ndc80 CH" evidence="12">
        <location>
            <begin position="54"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5595" evidence="13">
        <location>
            <begin position="216"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Kinetochore protein NDC80 loop region" evidence="14">
        <location>
            <begin position="379"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="267"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="323"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="467"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF18077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF24487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005010639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="644" mass="74240" checksum="39BDADE75551AFAD" modified="2022-01-19" version="1">MKRSSTTGGSGWQSTMVLRVQDNNKMGLQTPQMKDRGTFGKLSMSKTTSATSERKVSFFGKRASGAGGSRNSQYGVFGTEKIKDPRPLHDKTFIQQCIKQLCEFLVENGYAHNVTIKSLQSPSVKDFVKIFTFIYGFLCPSYELPDSKFEEEIPRVFKELGYPFPLSKSSMYTVGAPHTWPQIVAALIWLTDCFKLYSAMRENPSSFDDGQNWGGETDDGIVHNKLFLDYAIKCYEHFMKGGDTYEELDAEVQSKLKVLFNVDEFKTEGLAAENKRLLEEIARLEKERESEPDRLVSLRKLRSSFQSDVQKFQSYLTNLESHTAILDQKIRVVNEEIEAAEMEVEAMKQENARLQHIFDNQKYSVADIERINHERNELQQTINKLTKELEAEEHQLWNEELKYARNKEAIETQLAEYHKLARKLKLIPISAENSKGHDFEIHFNPEVGPNCLVKYRTQIKAPLMEIVNQTEEEIRKVTQRKMSLEDTLEQVNAMVAEKKSSVKTLKEEAEKLDDLYHQKLKEAEEEEQKCANELELLEKHKQLLESGVNDGLSEATNELHDIQRQYQIVMQTTTEESRKAGDNLNRLFEVITTQVVSIEKYLDEQNSKIDREYEEFMSEDLLSTLTGILESYKKKAESIKLPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TBU4</accession>
    <name>A0A8C2TBU4_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Bestrophin homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BEST4</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Forms chloride channels.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>chloride(in) = chloride(out)</text>
            <dbReference type="Rhea" id="RHEA:29823"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015725825.1">
        <property type="nucleotide sequence ID" value="XM_015870339.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TBU4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005016598.1">
        <property type="protein sequence ID" value="ENSCJPP00005011349.1"/>
        <property type="gene ID" value="ENSCJPG00005009749.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107317518"/>
    <dbReference type="KEGG" id="cjo:107317518"/>
    <dbReference type="CTD" id="266675"/>
    <dbReference type="GeneTree" id="ENSGT00940000160852"/>
    <dbReference type="OrthoDB" id="201595at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160133">
        <property type="term" value="F:bicarbonate channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005229">
        <property type="term" value="F:intracellularly calcium-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000615">
        <property type="entry name" value="Bestrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021134">
        <property type="entry name" value="Bestrophin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10736">
        <property type="entry name" value="BESTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10736:SF55">
        <property type="entry name" value="BESTROPHIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01062">
        <property type="entry name" value="Bestrophin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0868">Chloride</keyword>
    <keyword evidence="7" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="408"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="422"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005011349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="486" mass="55868" checksum="9ABF1E599DFD3D92" modified="2022-01-19" version="1">MTVSYTLKVANSRFGGFSKLLFRWKGSIYKLLYKEFIVFVVLYALLSIVYRRLLTEEQKRLYTKVAQYCNRSTDLIPMSFVLGFYVTLIVNRWWAQYTSIPMPDQLMCVISSNVHGKDERGRILRRTLVRYANLCSVLILRSVSTAVYKRFPSMEHVVEAGFMTQDERKQFESLYSDFNKYWIPCVWFTNLAAQARRDGRIRDDVALRLLMDELNLFRAKCSMLFHYDWISIPLVYTQVVTIAVYSFFAFCLIGRQFLEPLEPGQEGDLDMYIPLSTLLQFFFYAGWLKVAEQIINPFGEDDDDFETNKLIDRNLQVSLLSVDDMYQNLPPATKDKYWNESTAQPPYTMATAAETLKPSFLGSTFDMRMTEDMEQSQTVEASPNMARTQTPLLSRFLTAASPAISIKNFGRGGRATPHLRRARGDSTAHCEDPEAVSRIEEEETEDEESQKGSPRSPKASNKLPLIQVEAPSREIIEDEQPGAGEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TD39</accession>
    <name>A0A8C2TD39_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="36">Tyrosine-protein kinase receptor</fullName>
            <ecNumber evidence="36">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="42" type="primary">NTRK2</name>
    </gene>
    <organism evidence="42 43">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="42" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="42" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="42" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="31 36">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Axon</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Dendrite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Endosome membrane</location>
            <topology evidence="4">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="30">Postsynaptic density</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="36">Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="36"/>
    <dbReference type="RefSeq" id="XP_015704734.1">
        <property type="nucleotide sequence ID" value="XM_015849248.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TD39"/>
    <dbReference type="Ensembl" id="ENSCJPT00005016007.1">
        <property type="protein sequence ID" value="ENSCJPP00005010890.1"/>
        <property type="gene ID" value="ENSCJPG00005009418.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107306253"/>
    <dbReference type="CTD" id="4915"/>
    <dbReference type="GeneTree" id="ENSGT00940000155181"/>
    <dbReference type="OrthoDB" id="3256376at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome Z"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043197">
        <property type="term" value="C:dendritic spine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043195">
        <property type="term" value="C:terminal bouton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
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            <dbReference type="ARBA" id="ARBA00034105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="PIRSR" id="PIRSR620777-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="PIRSR" id="PIRSR620777-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="PIRSR" id="PIRSR620777-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="35">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="36">
        <source>
            <dbReference type="RuleBase" id="RU000312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="37">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="38">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="39">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="40">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="41">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="42">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005010890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="43">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="818" mass="91586" checksum="AB50758F0D253F8C" modified="2022-01-19" version="1">MVSWRRRPGPGLARLWGLCCLVLGCWRGALGCPASCRCSSWRISCSEPVPGIASFPVPQRSAEDDNVTEIYIANQRKLESINDNEVGFYVGLKNLTVVDSGLRFVSRQAFVKNVNLQYINFSRNKLSSLSKKPFRHLGLSDLILVDNPFKCSCEIMWIKKFQETKFYTEAQDIYCVDDNDKRTALMDMKVPNCDLPSANLSNYNITVVEGKSITLYCDTTGGPPPNVSWVLTNLVSNHESDTSKNPASLTIKNVSSMDSGLWISCVAENIVGEVQTSAELTVFFAPNITFIESPTPDHHWCIPFTVKGNPKPTLQWFYEGAILNESEYICTKIHVINQSEYHGCLQLDNPTHLNNGAYTLLAKNEYGEDEKRVDAHFMSVPGDGSGPIVDPDVYEYETTPNDLGDTTNNSNQITSPDVSNKENEDSITVYVVVGIAALVCTGLVIMLIILKFGRHSKFGMKGPSSVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNRPAELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPKEVYDLMLGCWQREPHMRLNIKEIHSLLQNLAKASPVYLDILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TD60</accession>
    <name>A0A8C2TD60_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">E3 ubiquitin-protein ligase RNF26</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">RING finger protein 26</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">RNF26</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">E3 ubiquitin-protein ligase that plays a key role in endosome organization by retaining vesicles in the perinuclear cloud. Acts as a platform for perinuclear positioning of the endosomal system by mediating ubiquitination of SQSTM1 through interaction with the ubiquitin conjugating enzyme UBE2J1. Ubiquitinated SQSTM1 attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport. Also acts as a regulator of type I interferon production in response to viral infection by mediating the formation of 'Lys-11'-linked polyubiquitin chains on TMEM173/STING, leading to stabilize TMEM173/STING. Also required to limit type I interferon response by promoting autophagic degradation of IRF3.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Interacts with INCA1. Interacts with TMEM43, ENDOD1, TMEM33 and TMED1 to form a complex capable of modulating innate immune signaling through the cGAS-STING pathway. Interacts with UBE2J1; this interaction is important for SQSTM1 ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2TD60"/>
    <dbReference type="Ensembl" id="ENSCJPT00005015828.1">
        <property type="protein sequence ID" value="ENSCJPP00005010739.1"/>
        <property type="gene ID" value="ENSCJPG00005009303.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000016584"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050687">
        <property type="term" value="P:negative regulation of defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905719">
        <property type="term" value="P:protein localization to perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032479">
        <property type="term" value="P:regulation of type I interferon production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16788">
        <property type="entry name" value="mRING-HC-C3HC5_RNF26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000387">
        <property type="entry name" value="RING finger protein 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040089">
        <property type="entry name" value="RNF26_mRING-HC-C3HC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22696">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22696:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 18" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="130"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="21">
        <location>
            <begin position="371"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="316"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00057605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00063040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00067352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00075536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005010739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="424" mass="46415" checksum="CFB4FC4E767E0D94" modified="2022-01-19" version="1">MELVLLLLRGLRLALDLLLLLLDLNFFLVSSLVTALIWLFTTASSLPGAATAGIWACWNGLLNGLCGLVLGVVQGVGGMLRGCCNVMEGLKVLGHLLTHMGLRGREMLQRGVCSLLGSGQAVLREAGEGLAIGISLLAYLVNSVVNLCLLGTQNLFTLLLALWDAVTSPVLRVGELLAAFLAHVSSSAIAVSILLWSPCQLAFELLVSTTELLIGIFFVNVYGLALLVAIIVVSAVIFNPGLLLTFLGHVFGYFHTLPAYPRLQQEVWRLYQLAVLMMGMAMTSQTWRRLVDWSLQVTNWSRGEQVPQAHPALNRSAVSGQRLQASRDEPSTSWGKAPRREQLNATAGDGAGAPDNDPWMLLKEQEERKKCVICQDQTKTVLLLPCRHLCLCQECTEVLLQQAIYQRNCPLCRQMILQTLNVYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TDN1</accession>
    <name>A0A8C2TDN1_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chaperonin containing TCP1 subunit 6B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">CCT6B</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TDN1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005017645.1">
        <property type="protein sequence ID" value="ENSCJPP00005012165.1"/>
        <property type="gene ID" value="ENSCJPG00005010046.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156339"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03342">
        <property type="entry name" value="TCP1_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000038">
        <property type="entry name" value="Chaperonin containing TCP1 subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000029">
        <property type="entry name" value="Chaperonin containing TCP1 subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000022">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000004">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012722">
        <property type="entry name" value="Chap_CCT_zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02347">
        <property type="entry name" value="chap_CCT_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005012165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="551" mass="59840" checksum="FF7E4758248F7960" modified="2022-01-19" version="1">ASLQTRLWAPVSKQEARGSAAMAVKALNPKAEVARAQAALAVNISAARGLQDVLRTNLGPKGTMKMLVSGAGDIKLTKDGNVLLQEMQIQHPTASLIAKVATAQDDITGDGTTSNVLIIGELLKQADLYISEGLHPRIVAEGFEIAKEKALEVLEKVKVSKEMDRETLIDVAKTSLRTKVHTELADILTEAVVDSVLAVRKPGEPIDLHMVEIMEMKHKSETDTTLIRGLVLDHGARHPDMKKRVEDAYILTCNVSLEYEKTEVSAGFFYKSAEEREKLVKAERKFIEDRVSKIIDLKRKVCSDSDKGFVVINQKGIDPFSLDALAKEGIVALRRAKRRNMERLTLACGGTAMNSVEDLTPDCLGHAGLVYEYTLGEEKYTFIEKCDNPRSVTLLIRGPNKHTLTQIKDAVRDGLRAVKNAIEDGCVIPGAGALEVAVANALVKHKPNVKGRAQLGVQAFADALLIIPKVLAQNSGYDPQETLVKVQAEHAESGQLIGVDLNTGEPMVAAAAGIWDNYNVKKQLLHSCTVIASNILLVDEIMRAGMSSLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TF22</accession>
    <name>A0A8C2TF22_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UEV and lactate/malate dehyrogenase domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">UEVLD</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(S)-lactate + NAD(+) = pyruvate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23444"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.27"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:23445"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="2">
            <dbReference type="Rhea" id="RHEA:23446"/>
        </physiologicalReaction>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TF22"/>
    <dbReference type="Ensembl" id="ENSCJPT00005018319.1">
        <property type="protein sequence ID" value="ENSCJPP00005012684.1"/>
        <property type="gene ID" value="ENSCJPG00005010772.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000164122"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004459">
        <property type="term" value="F:L-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006089">
        <property type="term" value="P:lactate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05293">
        <property type="entry name" value="LDH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11685">
        <property type="entry name" value="UEV_TSG101-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008883">
        <property type="entry name" value="UEV_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43128">
        <property type="entry name" value="L-2-HYDROXYCARBOXYLATE DEHYDROGENASE (NAD(P)(+))"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43128:SF33">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2 VARIANT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05743">
        <property type="entry name" value="UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00086">
        <property type="entry name" value="LLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51322">
        <property type="entry name" value="UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UEV" evidence="3">
        <location>
            <begin position="2"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00048275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005012684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="470" mass="51203" checksum="F57F1D6031C919C9" modified="2022-01-19" version="1">MAVSADALRKQLGKYKFRDLTVEEVTAVSRAHPNFAFSMNTYTFKDGSQKDLLNFSGTIPVKYGNSYNIPIRLWILDSHPFAPPICFLKPTANMGISVGKHVDAHGRIYLPYLQNWSHPKSTIIGLIKEMIAKFEEELPLYSLSSSDADRQSELLSYIARITEGETDIKSKSKIGGVRNGGCFNKVTVVGAGDLGIACVLAVVAKGVADKVVLLDLSEGAAKGGTMDLEIFALPNVEISKDFSASTDSKVVVLTVNSLGNAQTYLDVIQSNVDLFRGIIPAISHYSQNSVLLVASQPVEIMTYVSWKLSAFPKSRVIGVGGNLDTERFQYILTKLLQAEAVGKDAWIVGEQGEDKVPSWTNFNQSYVSPFPGLYRAVEVLKGKGQRSWSVGLSVADLTDSIMKDKRKVHSVSTLAKGFCNINSEVFLSLPCILGTSGVVETVALEEDPEVQEKLQSSAGSIHDLQQQLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TGD0</accession>
    <name>A0A8C2TGD0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">WD repeat-containing protein 35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">WDR35</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">As a component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is involved in ciliogenesis and ciliary protein trafficking. May promote CASP3 activation and TNF-stimulated apoptosis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the IFT complex A (IFT-A) complex. IFT-A complex is divided into a core subcomplex composed of IFT122:IFT140:WDR19 which is associated with TULP3 and a peripheral subcomplex composed of IFT43:WDR35:TTC21B. Interacts directy with IFT122, ITF43 and TTC21B. Interacts with IFT43. Interacts with CFAP61.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
            <location evidence="12">Cytoskeleton</location>
            <location evidence="12">Microtubule organizing center</location>
            <location evidence="12">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
            <location evidence="12">Cytoskeleton</location>
            <location evidence="12">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TGD0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005019204.1">
        <property type="protein sequence ID" value="ENSCJPP00005013354.1"/>
        <property type="gene ID" value="ENSCJPG00005011144.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155745"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030991">
        <property type="term" value="C:intraciliary transport particle A"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097730">
        <property type="term" value="C:non-motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990830">
        <property type="term" value="P:cellular response to leukemia inhibitory factor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035721">
        <property type="term" value="P:intraciliary retrograde transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061512">
        <property type="term" value="P:protein localization to cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000004">
        <property type="entry name" value="WD repeat-containing protein 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000187">
        <property type="entry name" value="WD repeat-containing protein 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056158">
        <property type="entry name" value="Beta-prop_IFT121_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056159">
        <property type="entry name" value="Beta-prop_IFT121_TULP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039857">
        <property type="entry name" value="Ift122/121"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057979">
        <property type="entry name" value="TPR_IFT121"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056157">
        <property type="entry name" value="TPR_IFT80_172_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057361">
        <property type="entry name" value="TPR_WDR35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017233">
        <property type="entry name" value="WDR35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056170">
        <property type="entry name" value="Znf_IFT121-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12764:SF5">
        <property type="entry name" value="LD29485P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12764">
        <property type="entry name" value="WD REPEAT DOMAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23390">
        <property type="entry name" value="Beta-prop_WDR35_2nd"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24797">
        <property type="entry name" value="Beta-prop_WDR35_TULP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25768">
        <property type="entry name" value="TPR_IFT121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23387">
        <property type="entry name" value="TPR_IFT80_172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25170">
        <property type="entry name" value="TPR_WDR35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23145">
        <property type="entry name" value="Zf_2nd_IFT121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037536">
        <property type="entry name" value="WD_repeat_p35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6 12" id="KW-0969">Cilium</keyword>
    <keyword evidence="5 12" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="2 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 13" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="IFT121/TULP4 N-terminal" evidence="17">
        <location>
            <begin position="1"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="67"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="IFT121 second beta-propeller" evidence="16">
        <location>
            <begin position="339"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="IFT121 second beta-propeller" evidence="16">
        <location>
            <begin position="487"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="IFT80/172/WDR35 TPR" evidence="15">
        <location>
            <begin position="666"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="domain" description="IFT121-like TPR repeats" evidence="18">
        <location>
            <begin position="987"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="domain" description="IFT121-like zinc finger" evidence="14">
        <location>
            <begin position="1104"/>
            <end position="1145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00058990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00062232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR037536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF23145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF23387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF23390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF24797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF25768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005013354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1146" mass="130410" checksum="89A75B2F58943633" modified="2022-01-19" version="1">MFIYLCKKIAIPGNVRLRCISWNKDEGFIACGGEDGLLKVLKLETQTDEAKIKGLAAPSNLSMNQNLEGHSGSVQVVTWNEQYHKLTTSDQNGLIIVWIIYKGSWFEEMINNRNKSVVRSMSWNADGQKICIVYEDGAVIVGSVDGNRIWGKDLKGTHLCHVAWSSDSKVLLFGMANGEIHIYDSNGNFIVKMKLSCLVNLTGTFRIAGIHWYHGTEGYVEPDCPCLAVCYENGRCQIMRDENDHNPVLIDAGMNIVCIQWNHCGSVLALAGSLKGTSPDKDVNVVQFYTPFGEHLRTLKVPGKQISALSWEGGGLKIALAVDSYIYFANIRPDYKVMGYCSNTLVYAYTRPDRPEYCVSEKCYFINYFRTLCSCAICTMLTREYYNSHTIPFEEKCINNTFISLQYVLVLCNSIGTPLDPKYIDIGPLFVTMTKTHVIAASKEAFYIWQYRVAKRLTAMEINQVARTRKEGRERFGDDVPSSHIGSGRESGTIHRYSLPNVGIIQKYTLNYRAHQLSLNCNSSRVAIIDLSGVLTFFDLDARVTSSTGQQVIGEQLKLERKDVWDMKWAKDNPDLFAVMEKTRMYVFRNLDPEEPIQTSGYICNFEDLEIKSVLLDEILKNPERPNKDYIINFEIRSLRDSRALIEEVGIEESSQFIEDNPHPRLWRLLAEAALQKLDLQTAEQAFVRCKDYQGIKFAKRLGNLQSESMKQAEVAAYFSRFEEAERMYLDMDRRDLAIGLRIKLGDWFRVLQLLKTGSGDSDDALLEQAHNAIGDYFADRQKWLNAVQYYVQGRNQERLAECYYMLEDYEGLENLVNSLPENNKLLPDIAHMFVRVGMCEQAVAAFLKCNRPKDAVDTCVHLNQWNKAVELAKNHNMKEIGSLLARYATHLLEKNKILDAIELYRKANYFFEAAKLMFKIADEEAKKRTKPLRVKKLYVLSALLMEQCHEQMQNAQRGKVKGSETASALAGLLEEDVLSSTSRFADNAWRGAEAYHFFILAQRQLYKGSVDAALKTALHLRDYEDIIPAVEIYSLLAVCACANRAFDTCSKAFVKLESLETLSQEQRQQYEDLALEIFTRHCPKNTKKTDLDDVLESGDGKLPVCVATGDPILEYRFWMCSVCKHCMKAKERSNYNFCPLCHCSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TI05</accession>
    <name>A0A8C2TI05_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TI05"/>
    <dbReference type="Ensembl" id="ENSCJPT00005020215.1">
        <property type="protein sequence ID" value="ENSCJPP00005014147.1"/>
        <property type="gene ID" value="ENSCJPG00005011842.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157856"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051213">
        <property type="entry name" value="START_lipid_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308">
        <property type="entry name" value="PHOSPHATIDYLCHOLINE TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308:SF8">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="START" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005014147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="446" mass="48085" checksum="64D07697650B9117" modified="2022-01-19" version="1">MLLLVQLDTEYRKQWDSLVIKLDVIERDAATGSEVIHWVTHFPYPMYSRDYVYVRRYRVDKENNLMVLVSRWVVLTHTELNGAGWMDPVCSALSCPKSPGVHLGSWCDLIPPFLPPAPFPPPSPPFLLHPPFPFPSSFLPPLPLTPPSSSFPLPPFCSLSPLHPPISFLLPLSPLSSPHLLPPSFSFSPLSFPSPPHPPVPFPSSLSPLHPPIPLPSSFLPPHPPVPSALSPHPSSSHLLLPFCPLSPLHPSPHLLPAPSPLSPPSWPLSSLSSPHLLPHNFPFSPLSFLFPLPLPPPVPSALSPSILPSLSLPPSCPLSPPFLSPSPSSLLPLLPPPSSHPSPFLLSPPSSSCPFCPLPPSSIVPSPFLPPFFPLSLLHPPIPLPISFLPLLPPLPLSFPITSPSPPSPFSSPSPPILHPPIPLPPFLLPPLPPPPSQAIPAPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TI24</accession>
    <name>A0A8C2TI24_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Somatomedin B and thrombospondin type 1 domain containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">SBSPON</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TI24"/>
    <dbReference type="Ensembl" id="ENSCJPT00005019977.1">
        <property type="protein sequence ID" value="ENSCJPP00005013958.1"/>
        <property type="gene ID" value="ENSCJPG00005011718.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000008325"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000019">
        <property type="entry name" value="Thrombospondin type 1 domain containing 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039942">
        <property type="entry name" value="SBSPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056801">
        <property type="entry name" value="SBSPON_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001212">
        <property type="entry name" value="Somatomedin_B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044004">
        <property type="entry name" value="TSP1_spondin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20920">
        <property type="entry name" value="RPE-SPONDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20920:SF2">
        <property type="entry name" value="SOMATOMEDIN-B AND THROMBOSPONDIN TYPE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25031">
        <property type="entry name" value="SBSPON_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19028">
        <property type="entry name" value="TSP1_spondin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50958">
        <property type="entry name" value="SMB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SMB" evidence="5">
        <location>
            <begin position="114"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="32"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005013958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="357" mass="39103" checksum="99D336EF27AB8F73" modified="2022-01-19" version="1">MTLTILCRAMAEQDGSARYTALQVTIKVGPPATRTTAPRLSITSASHSARSLLSRGREGRAETPRPPPPRSAARPPAQPAPRCRVSVEAVGDMGFAFLSGALCLGLLCRLLSEADGSCSERCCQGRDAACVSSGWREDGGYGTCYCDGECRRTRDCCHDHGHACPAHPCIVGEWSHWSGCAEQCKPSLRIRRRYVQQEPTNAGEPCPALEEKAGCLEYLTYQGQDCGQEHVPAFITTSEYGKERKLRAASSPRTSDKETGYCVEFKTESLSHDCALENRPYARWMQYLREGHTVCVACQPPAMNTDTHRCSGDGHNADGGKILHWEAVGNSQCQGTWKKIRQLKQCSCPLVHSFVFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TIB3</accession>
    <name>A0A8C2TIB3_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Enhancer of mRNA-decapping protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">EDC4</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">P-body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat EDC4 family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSCJPT00005020405.1">
        <property type="protein sequence ID" value="ENSCJPP00005014315.1"/>
        <property type="gene ID" value="ENSCJPG00005011956.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00510000047791"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031087">
        <property type="term" value="P:deadenylation-independent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.100:FF:000001">
        <property type="entry name" value="Enhancer of mRNA-decapping protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000138">
        <property type="entry name" value="Enhancer of mRNA-decapping protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.100">
        <property type="entry name" value="conserved c-terminal region of ge- 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045152">
        <property type="entry name" value="EDC4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049404">
        <property type="entry name" value="EDC4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044938">
        <property type="entry name" value="EDC4_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032401">
        <property type="entry name" value="EDC4_WD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15598">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15598:SF5">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21289">
        <property type="entry name" value="EDC4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16529">
        <property type="entry name" value="Ge1_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 10" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Enhancer of mRNA-decapping protein 4 WD40 repeat region" evidence="13">
        <location>
            <begin position="147"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="326"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Enhancer of mRNA-decapping protein 4 C-terminal" evidence="14">
        <location>
            <begin position="1303"/>
            <end position="1423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="689"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="745"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="852"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="982"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="689"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="868"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="966"/>
            <end position="979"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF21289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005014315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1436" mass="157729" checksum="2405855E36BE43D4" modified="2022-01-19" version="1">MFPAGAPPANGPEAETWVAGRDCAAGRAGSGPGPMASSNSIDIEDATQHLRDILKLDRPGGSVNESQRPSSSYNGDLNGLLVPDPLVAGDGPTLTKPVHRSISLGAVQEKQVICLSGDDSSTCIVISAKDVEIVASSDSSITSKARGSNKVKIQPVARYDWEQKYYYGNLIAVSNSYLAYAIRAASNGSAMVRVLSVSTAERTLLKGFTGGVADLAFAHLNSNQLACLDEAGNLFVWRLSMEKDKIQEEILVNIKRPDGTPLNTSRRIIWCPFIPDDSEENSEEGSQTLALLHEDRAEVWDLDIIRSNNRSWPVEVPNIKEGFIVVKGHSTYLSEGALSPDGTVLATASHDGFVKFWQIYIEGQDEPRCLHEWKPHDGRPLSCLLFCDNHKKQDPEVPFWRFLITGADQNRELKMWCTVFWTCLQTVRFSPDIFSSMSILPSLKVCLDLSAEYLILSDVQRKVLYVMELMQNQEEGKAYFSSISEFLLTHPVLSFGIQAVSRCRLRHTEVLPAEEENDNLSIEGAQGAGAVESAAGVLIKLFCVHTKALQDVQIRFQPLHSPDMGASVPSHGSHEEFAFPDHIADLGTEGLGSEKGSVHGSQQDLRRIADLPVPADFLSLSNDAKPKLMTPDAFMTPSTSLQQITVSPGSSVSSLTAVTAMSSTSVTDVSMSRPSEDLTVSPKMQLDTSLTLSSSSSSLQTSPRSHSVLIPGLPEKLTPKAPVPVTPGNSSLALELQEVEPLVVPQASPTRERSPDVISSASTAMSQDIPEIASETLQRSFAAAPSALSAEVLEPSHHADSMASAASALHLLSPRNRHNSEHSHHSLDMPPVEVDRLNAPSLLETALTQENASLDSVVSQPWPAAPDITRETRNSMADSPRDEVEEKHKSSSYHRHSYHLLQHDSQDASAEQSDHDDEVASLASTSGGFGAKASTQRLPVKDWKAKASPRASPKLKRKGKKDDGDVNQSPRSSNNQVTPEFQEELMCVLRSQQRELSELRQNQMELLQRLTDHLDAIQSSLMGHMERVIDSQQEQEQRRLDRALTEGQQRNGQLQEHLSQQLSQTLSNAVCNRLERTVREEMKKTVPQCISKSLDPVAGQLSNTIATKLTAVEGTLKENITKLVKSKNLTDSVVRATADTLQGPIQSAYREAFQSIVLPAFEKSCQSMFQQINDTFKQGTQEYVQQLETHMKNKKAREQEARDPLLNQLRQLISTFQSTTEQLASTIAANIHAEVQHQLHIIVSNLQESILTQVQRVIKGEVSLAMKEQQAAVTSSIVQAMRSAAGTPIPSTHLDFQSQQTHILQLLQQGHLNQAFQQALTASDLNLVLYVCETVDTQQVFGQQPCPLSQPVLLSLIQQLSSDLGTRTELKLNYLEEAVMHLDHSDPITRDHMGSVMSQVRQKLFQFLQVEPHNTLSKPARRLMIMLQGLVTPGMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TIH1</accession>
    <name>A0A8C2TIH1_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Retinol dehydrogenase 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">RDH14</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TIH1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005018962.1">
        <property type="protein sequence ID" value="ENSCJPP00005013154.1"/>
        <property type="gene ID" value="ENSCJPG00005011121.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107312293"/>
    <dbReference type="KEGG" id="cjo:107312293"/>
    <dbReference type="GeneTree" id="ENSGT00940000160181"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052650">
        <property type="term" value="F:all-trans-retinol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF72">
        <property type="entry name" value="RETINOL DEHYDROGENASE 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005013154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="354" mass="38444" checksum="9766ACE2742DB640" modified="2022-01-19" version="1">MRLGGRSLTQPRAQPCAHAGRSAAGPAAMAPAALTAALLGGGLLLAAWRWLRAAARRGAGAGASMRGKTVIITGANSGLGRAAATELLRMKARVIMGCRDRARAERAAREIRAELGEREAAEGGGELVVRELDLASLRSVRAFCHRVLQEEPRLDVLINNAGIFQCPYMKTEDGFEMQFGVNHLGHFLLTNLLLGLLKNSAPSRIVVVSSKLYKYGEINFEDLNSDISYNKSFCYSRSKLANILFARELARRLEGTGVTVNSLHPGIVRTNLGRHVNIPLLAKPLFNLVSWAFFKTPLEGAQTSIYLASSPDVEGVSGKYFGDCKEEELLPKAMDDLVARKLWDISEVMVGLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TIK0</accession>
    <name>A0A8C2TIK0_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Coiled-coil-helix-coiled-coil-helix domain containing 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">CHCHD2</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TIK0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005017653.1">
        <property type="protein sequence ID" value="ENSCJPP00005012171.1"/>
        <property type="gene ID" value="ENSCJPG00005010355.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00440000038159"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140297">
        <property type="term" value="F:DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905448">
        <property type="term" value="P:positive regulation of mitochondrial ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900037">
        <property type="term" value="P:regulation of cellular response to hypoxia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010625">
        <property type="entry name" value="CHCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055304">
        <property type="entry name" value="CHCHD2/10-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13523">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 2/NUR77"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13523:SF3">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN-CONTAINING PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06747">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHCH" evidence="3">
        <location>
            <begin position="110"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005012171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="146" mass="15046" checksum="C2529920C833E953" modified="2022-01-19" version="1">MPRGGRSRSSRVAPPASRVPQMRAAPPAPAPAPANAVAAPAPKQPGLMAQMATTAAGVAVGSAVGHTIGHAITGGFGGGSAAEPAGPDITYQEPQAAQPSYQQQQQFAPCQYEMKQFLECAQNQTDLKLCEGFSEVLKQCRFANGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TIZ0</accession>
    <name>A0A8C2TIZ0_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chromosome 5 open reading frame 34</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">C5orf34</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TIZ0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005018733.1">
        <property type="protein sequence ID" value="ENSCJPP00005013007.1"/>
        <property type="gene ID" value="ENSCJPG00005011000.1"/>
    </dbReference>
    <dbReference type="KEGG" id="cjo:107305949"/>
    <dbReference type="GeneTree" id="ENSGT00500000044987"/>
    <dbReference type="OrthoDB" id="75908at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome Z"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053901">
        <property type="entry name" value="C5orf34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053899">
        <property type="entry name" value="C5orf34-like_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027865">
        <property type="entry name" value="C5orf34-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053900">
        <property type="entry name" value="C5orf34-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027830">
        <property type="entry name" value="C5orf34-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34531:SF1">
        <property type="entry name" value="CHROMOSOME 5 OPEN READING FRAME 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34531">
        <property type="entry name" value="ZGC:153352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15025">
        <property type="entry name" value="C5orf34-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22833">
        <property type="entry name" value="C5orf34_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15016">
        <property type="entry name" value="C5orf34_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22834">
        <property type="entry name" value="Polo_box_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C5orf34-like N-terminal" evidence="3">
        <location>
            <begin position="7"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="C5orf34-like second" evidence="4">
        <location>
            <begin position="120"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="C5orf34-like" evidence="5">
        <location>
            <begin position="333"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="C5orf34-like C-terminal" evidence="2">
        <location>
            <begin position="448"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="584"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005013007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="631" mass="71591" checksum="5B938B221FDA0617" modified="2022-01-19" version="1">MAAERLMVLYGDDSVEVHYADGARLLLSPCGSEYLYEEPLPAAAHPLQPAGSTRQRVPFVISAYREQILRALDFRNTFSSRPYLPSRIIPPERKRIIFSDALEVRWPDPVTADLTRCIRNGSVKISSVDGYAHLYLSELQQEFTVEFLCKVSQPFAASSRFSPKNSNYKTEDQSGKSSKNPVPEISSKQMRNDYKNSEDGHTEGEYREATKPDNQGDRGGVPLFSTSCSSEYTWVTQRWSVSSCPEEWKYPLSLALMCYSLHTAKNILKTCDENNHASIGADVLTDPKAYEAVSRLPVALPISCRAPHLHRWSFCDFFLQKNQDSEYSHPQLIHIVWCNGVFYRFIHGRRNITEIYPGDESLLKSEGDFLGNYFVHYAIQKGIEKREEKMYSVNSLPPDVPGSQYSISSIITEATKMLQYCYKTKLSLIHNFHLCCWKMVPETDGREMLPVLLAEKVNPGIGRLLVYSDHKVHAAFCDGISLNMVWDFSSCYTKIQVNEDVGWCKLTTPDGVQQLIQIRHPGIYERYIRTVIGWCRSLNESEETPEFTTHTVTEENWSADAELQKIQRFNFLLDNCNVLEGTSAAKNSPSAKKSESGTDPEEMCEGHVLEALQNTSRIIQDIESLLARAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TJF8</accession>
    <name>A0A8C2TJF8_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GDT1 family protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GDT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TJF8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005018171.1">
        <property type="protein sequence ID" value="ENSCJPP00005012556.1"/>
        <property type="gene ID" value="ENSCJPG00005010678.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000005261"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015085">
        <property type="term" value="F:calcium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032468">
        <property type="term" value="P:Golgi calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032472">
        <property type="term" value="P:Golgi calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001727">
        <property type="entry name" value="GDT1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12608:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 165"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12608">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN HTP-1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01169">
        <property type="entry name" value="GDT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005012556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="110" mass="11697" checksum="D41E76B36AD245CD" modified="2022-01-19" version="1">MAAITKSNTTNVVSWMEAAMWMLFQQAIPDLTSRFSIALMFPFPSVFSPQDPYGVAVGGTVGHCLCTGLAVIGGRMIAQKISVRTVTIIGGIVFLAFAFSALFISPDSGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TJM3</accession>
    <name>A0A8C2TJM3_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TJM3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005020699.1">
        <property type="protein sequence ID" value="ENSCJPP00005014558.1"/>
        <property type="gene ID" value="ENSCJPG00005012135.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154136"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33332">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005014558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="402" mass="46369" checksum="89104A20EF20B90D" modified="2022-01-19" version="1">MYPHQLAVRLKKKTLNEQQISKPCGRPSAPRHKQCRRTPCWQQGCFVSRPSRQGKRSKAFDTVSHAVLLQKLAARGLDEYTLGWVRSWLEGRAQRVVVNGVKSSWRPVMSGVPQGSVLGPVLFNIFIDDLDEGIECTLSKFMDDTKLAGSVDLPGGIEALQRDLDRLESWAEANGMRFNKTKCRVLHFGHNNPRQRYRLGAEWLEDCVEETDLGVLIDARLNMSRQCARVAKKANSILACIKNSVTSRNREVIVPLYSALVWPHLEYCVQFWAPHCKKDIAALERVQRRAMKLVMGLEHRPYEERLRELGLFSLEKRRLRGDFIALYNFLKGGCRELGVGLFSRVINDRTRGNGFKLHQGRFRLNIRKYYFSERMVRHWNALPREVLESPTMQVFKKCLDLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TL49</accession>
    <name>A0A8C2TL49_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TNF receptor superfamily member 18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">TNFRSF18</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015738142.1">
        <property type="nucleotide sequence ID" value="XM_015882656.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TL49"/>
    <dbReference type="Ensembl" id="ENSCJPT00005019123.1">
        <property type="protein sequence ID" value="ENSCJPP00005013290.1"/>
        <property type="gene ID" value="ENSCJPG00005011223.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107323504"/>
    <dbReference type="KEGG" id="cjo:107323504"/>
    <dbReference type="CTD" id="8784"/>
    <dbReference type="GeneTree" id="ENSGT00940000166589"/>
    <dbReference type="OrthoDB" id="9374769at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005031">
        <property type="term" value="F:tumor necrosis factor receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045785">
        <property type="term" value="P:positive regulation of cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13417">
        <property type="entry name" value="TNFRSF18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001368">
        <property type="entry name" value="TNFR/NGFR_Cys_rich_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022318">
        <property type="entry name" value="TNFR_18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053107">
        <property type="entry name" value="TNFRSF18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034018">
        <property type="entry name" value="TNFRSF18_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47388">
        <property type="entry name" value="TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47388:SF1">
        <property type="entry name" value="TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01968">
        <property type="entry name" value="TNFACTORR18"/>
    </dbReference>
    <dbReference type="SMART" id="SM00208">
        <property type="entry name" value="TNFR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57586">
        <property type="entry name" value="TNF receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034452649" evidence="2">
        <location>
            <begin position="33"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="3">
        <location>
            <begin position="35"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="3">
        <location>
            <begin position="74"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="3">
        <location>
            <begin position="114"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005013290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="258" mass="29104" checksum="176B51B3AEA32422" modified="2022-01-19" version="1">MIVHGRESSLLNTRACLLLTLYLWLWAQQTLATSCPDGELRAISKDVKKCCPKCLSSTEDNSPCEGIDDVDCKCPQGFSCADRPCTSCKKTECSEGEELVKLGTIYYKYSCKPCEKGTYSNGKNSWCQSWTDCESSGLLTIQKGNSTHNSLCGYLVKYLEQDGVTRDSLYTTILAILTAVGLFVLILLTFFLHLCIWSLKKEKHPAADNVELNFQRLLLAPQTSHHREETYSCQFPEEEHGDKILDEKPYYFQPPSLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TLV8</accession>
    <name>A0A8C2TLV8_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Plasmolipin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Plasma membrane proteolipid</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">PLLP</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Forms oligomers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Myelin membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MAL family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015729262.1">
        <property type="nucleotide sequence ID" value="XM_015873776.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TLV8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005020476.1">
        <property type="protein sequence ID" value="ENSCJPP00005014376.1"/>
        <property type="gene ID" value="ENSCJPG00005012007.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107319136"/>
    <dbReference type="KEGG" id="cjo:107319136"/>
    <dbReference type="CTD" id="51090"/>
    <dbReference type="GeneTree" id="ENSGT00940000156011"/>
    <dbReference type="OrthoDB" id="6258237at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043209">
        <property type="term" value="C:myelin sheath"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019911">
        <property type="term" value="F:structural constituent of myelin sheath"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032288">
        <property type="term" value="P:myelin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904298">
        <property type="term" value="P:regulation of transcytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013295">
        <property type="entry name" value="MAL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050578">
        <property type="entry name" value="MARVEL-CKLF_proteins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22776">
        <property type="entry name" value="MARVEL-CONTAINING POTENTIAL LIPID RAFT-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22776:SF9">
        <property type="entry name" value="PLASMOLIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01884">
        <property type="entry name" value="MALPROTEIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51225">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="14">
        <location>
            <begin position="30"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00050024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005014376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="178" mass="19189" checksum="88DC065D144A9BD9" modified="2022-01-19" version="1">MAGLPGAAGTRSGSPGAAAAPPPPRLDEAFLCSPLGGLMGAQAVLGLLVWALIADTTYHLHAAYGWVLFVSIFLWVMTVVLFVMYLLQLPMKLYMVPWSLLLMIFNAVATVLYIAAFVTSSVAVRPTSWRQWDYNRRAAASFFAGLVMLTYGATTFFSFRAWKGLGGSAARSQADSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TLW8</accession>
    <name>A0A8C2TLW8_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">U6 snRNA-associated Sm-like protein LSm4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">LSM4</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TLW8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005020320.1">
        <property type="protein sequence ID" value="ENSCJPP00005014235.1"/>
        <property type="gene ID" value="ENSCJPG00005011900.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00610000086173"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120115">
        <property type="term" value="C:Lsm2-8 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071005">
        <property type="term" value="C:U2-type precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042731">
        <property type="term" value="F:PH domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01723">
        <property type="entry name" value="LSm4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034101">
        <property type="entry name" value="Lsm4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="2"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="86"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005014235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="138" mass="15424" checksum="61965B244E533991" modified="2025-10-08" version="2">MDLLTLIVTAHKHRQLVELKNGETYNGHLVSCDNWMNINLREVICTSRDGDKFWRMPECYIRGSTIKYLRIPDEIIDMVKEEVVSKGRGRGGMQQQKQQKGRGVGGAGRGVFGGRGRGIPGSGRGQQEKKPGRQSAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TMM4</accession>
    <name>A0A8C2TMM4_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Complex I subunit B13</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Complex I-13kD-B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">NADH-ubiquinone oxidoreductase 13 kDa-B subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">NDUFA5</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Complex I is composed of 45 different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFA5 subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TMM4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005020660.1">
        <property type="protein sequence ID" value="ENSCJPP00005014533.1"/>
        <property type="gene ID" value="ENSCJPG00005012109.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000008099"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006806">
        <property type="entry name" value="NDUFA5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12653:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12653">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 13 KD-B SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04716">
        <property type="entry name" value="ETC_C1_NDUFA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005014533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="116" mass="13485" checksum="D66DE5EBF695C247" modified="2022-01-19" version="1">GCVCFVQTTGLVGLAVAENPHERLRILYSKILAVLQNIPRDAAYRKYTEQIVNQRYNLVQTETDVQKLQDKLNGGQIEEVILQAENELSLARKMLQWKPWEPLVEEPPTDQWRWPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TMT8</accession>
    <name>A0A8C2TMT8_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zinc finger protein 385D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ZNF385D</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015709473.1">
        <property type="nucleotide sequence ID" value="XM_015853987.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TMT8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005021526.1">
        <property type="protein sequence ID" value="ENSCJPP00005015152.1"/>
        <property type="gene ID" value="ENSCJPG00005012593.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005021527.1">
        <property type="protein sequence ID" value="ENSCJPP00005015153.1"/>
        <property type="gene ID" value="ENSCJPG00005012593.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107309299"/>
    <dbReference type="KEGG" id="cjo:107309299"/>
    <dbReference type="CTD" id="79750"/>
    <dbReference type="GeneTree" id="ENSGT00940000155611"/>
    <dbReference type="OrthoDB" id="9448812at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000276">
        <property type="entry name" value="zinc finger protein 385A isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000121">
        <property type="entry name" value="zinc finger protein 385B isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000293">
        <property type="entry name" value="zinc finger protein 385B isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051845">
        <property type="entry name" value="Znf385"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23067">
        <property type="entry name" value="DOUBLE-STRANDED RNA-BINDING ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23067:SF12">
        <property type="entry name" value="ZINC FINGER PROTEIN 385D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="386"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="399"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="512" mass="55442" checksum="E5CA276BD2B6A239" modified="2022-01-19" version="1">MAGALGRGSACWRMRSGRKEKAPGGKPRQQHENMKKPWSPDLPASNHSYNLAFASIPDRDNEKELAADSTEEKKEREKKQTNFTLCNVCNIQLNSAAQAQIHYNGKSHQKRLKQLSNGSLKNDNGGTCQSPALPALVRPPAPPLQPSLDIKPFLPFPLDTAAAVNLFPNFNAMDPIQKAVINHTFGVPLPHRRKQIISCNICQLRFNSDSQAAAHYKGTKHAKKVKALEAMKNKQKSVTTKDSAKTTFTSITTNTINTSSDKPDVTTGTPAISTTTTVEIRKSSVMTTEITSKVEKIPTTATSSTTCPSVETEEEKAKRLLYCSLCKVAVNSASQLEAHNSGTKHKTMLEARNGSGTIKAFPRAGVKGKGPVNKGNTGLQNKTFHCEICDVHVNSETQLKQHISSRRHKDRAAGKPPKPKYSPYNKLQKGTHPLGVKLVFSKEPSKPMAPRILPNPLAAAAAAAAVAVNSPFSLRTAPAATLFQTSALPPALLRPAPGPIRTTHTPVLFAPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TN17</accession>
    <name>A0A8C2TN17_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Shugoshin 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">SGO1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the shugoshin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015709418.1">
        <property type="nucleotide sequence ID" value="XM_015853932.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TN17"/>
    <dbReference type="Ensembl" id="ENSCJPT00005021518.1">
        <property type="protein sequence ID" value="ENSCJPP00005015150.1"/>
        <property type="gene ID" value="ENSCJPG00005012590.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107309276"/>
    <dbReference type="CTD" id="151648"/>
    <dbReference type="GeneTree" id="ENSGT00940000154107"/>
    <dbReference type="OrthoDB" id="9901374at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045132">
        <property type="term" value="P:meiotic chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.730">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038889">
        <property type="entry name" value="Shugoshin1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011515">
        <property type="entry name" value="Shugoshin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21577">
        <property type="entry name" value="SHUGOSHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21577:SF3">
        <property type="entry name" value="SHUGOSHIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07557">
        <property type="entry name" value="Shugoshin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="8" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="6 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shugoshin C-terminal" evidence="11">
        <location>
            <begin position="541"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="324"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="405"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="526"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="52"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="328"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="413"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="476"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="605" mass="67768" checksum="3318DF16387FFF2A" modified="2022-01-19" version="1">MAEHLKKPFKDSLSDIKERMKEKRNQKWVSLGKKSQISTVKCKRATTTSVKMKSLQANNIALAQALQEEKLKLRDAQALIIQLRREYQDLKFQMFHLQRSLAFRQAEGLVETRLSALSEIISKVSQNLLESVDLLGPAKDLCSRSVNQRVRTSELENNSSDVGERSSVELLLPADGDDPILQSRLEADCEKSEPGHSVFEICRELDSGTSLAKIIPDKGQTSDCPVYNIASMLGGVFSGGEDEFGNELTKNVSTRRHCSKMSNRDELYTGVLDHLKASDSAKEPFKQDEIRLEESLDVYTVENIHSGISQVDKVGSELLLRQTDSETAKVSSGNSSDLKQRACKSREDSQVRRGKDQKVKMGGTKGTSRPRSKKRQCKETSKEKLGGSSDAYDFNFEESIHVTPFRQNKVNDADTDVDDKEESSESNSSKLSDTEEDSDDSLYVPHRNKSKKRKSSVDGPDSSPIHVRPRSKRCLAQREQKLHKEETEKKTEIIKSSEKSIRQSSKSFHGHLCDVTNIASLLSKENAPVGPAGERSPSPKRNRRSCTLSVNYKEPSIAGKLRRGDPFTDVCFLNSPIFKQKKNAKHNSTKKKSLSEYNEKFVSGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TNB8</accession>
    <name>A0A8C2TNB8_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Desmin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">DES</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <location evidence="1">Sarcolemma</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Myofibril</location>
            <location evidence="2">Sarcomere</location>
            <location evidence="2">Z line</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10 11">Belongs to the intermediate filament family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TNB8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005023119.1">
        <property type="protein sequence ID" value="ENSCJPP00005016441.1"/>
        <property type="gene ID" value="ENSCJPG00005013513.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155522"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097512">
        <property type="term" value="C:cardiac myofibril"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005916">
        <property type="term" value="C:fascia adherens"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005882">
        <property type="term" value="C:intermediate filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031594">
        <property type="term" value="C:neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008092">
        <property type="term" value="F:cytoskeletal protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045109">
        <property type="term" value="P:intermediate filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006998">
        <property type="term" value="P:nuclear envelope organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060538">
        <property type="term" value="P:skeletal muscle organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1160:FF:000001">
        <property type="entry name" value="Keratin type II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000002">
        <property type="entry name" value="Type I keratin KA11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.500:FF:000001">
        <property type="entry name" value="Type II keratin 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.500">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1160">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018039">
        <property type="entry name" value="IF_conserved"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039008">
        <property type="entry name" value="IF_rod_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006821">
        <property type="entry name" value="Intermed_filament_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050405">
        <property type="entry name" value="Intermediate_filament"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45652:SF2">
        <property type="entry name" value="DESMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45652">
        <property type="entry name" value="GLIAL FIBRILLARY ACIDIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00038">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04732">
        <property type="entry name" value="Filament_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01391">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64593">
        <property type="entry name" value="Intermediate filament protein, coiled coil region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00226">
        <property type="entry name" value="IF_ROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51842">
        <property type="entry name" value="IF_ROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0403">Intermediate filament</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0514">Muscle protein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF rod" evidence="14">
        <location>
            <begin position="100"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="461"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="644"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="90"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="292"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="500"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="550"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="561"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="589"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005016441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="666" mass="74029" checksum="935FAB681CD64F22" modified="2022-01-19" version="1">MSQSYSSSQRVSSYRRTFGGGTSPVFPRASFGSRGSGSSVTSRVYQVSRTSAVPTLSTFRTTRVTPLRTYQSAYQGAGELLDFSLADAMNQEFLQTRTNEKVELQELNDRFANYIEKVRFLEQQNALMVAEVNRLRGKEPTRVAEMYEEELRELRRQIDALTGQRARVEVERDNLLDDLQKLKQRLQEEIQLKEEAENNLAAFRADVDAATLARIDLERRIESLQEEIAFLKKVHEEEIRELQAQLQEQHIQVEMDISKPDLTAALRDIRAQYESIAAKNIAEAEEWYKSKVSDLTQAANKNNDALRQAKQEMLEYRHQIQSYTCEIDALKGTNDSLMRQMREMEERFAGEAGGYQDTIARLEEEIRHLKDEMARQLREYQELMNVKLALDIEIATYRKLLEGEESRISIPMHQTFASALNFRETSPDQRGSEVHTKKTVMIKTIETRDGEVSAVCVCGGGQMGGEDRGHGIISRSFPSGGERGDPAAARGAVEDSVPVPSRPSAPPKPVLPPTRPPPGTARAPPTPPGSLLRLRKASQLAPGSGPGRGAAERDGGDKQEGVGGAGGGLGSQQRVLHPPAPRSPLPARGRSRRSRSRLPARHSSSPRSWRFSWVGLQRCRGRGEVGVLRGPGLCAPPLRCPRGSPVRGRRGRGCAGMGLAEQRGNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TNE2</accession>
    <name>A0A8C2TNE2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Eukaryotic translation initiation factor 2-alpha kinase 1</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Hemin-sensitive initiation factor 2-alpha kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">EIF2AK1</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="16">Synthesized in an inactive form that binds to the N-terminal domain of CDC37. Has to be associated with a multiprotein complex containing Hsp90, CDC37 and PPP5C for maturation and activation by autophosphorylation. The phosphatase PPP5C modulates this activation. Homodimer; homodimerizes in presence of heme, forming a disulfide-linked inactive homodimer. Interacts with DELE1; binds both to full-length DELE1 and processed form of DELE1 (S-DELE1) in response to stress, leading to activate its protein kinase activity and trigger the integrated stress response (ISR).</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="RefSeq" id="XP_032303566.1">
        <property type="nucleotide sequence ID" value="XM_032447675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TNE2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005023100.1">
        <property type="protein sequence ID" value="ENSCJPP00005016423.1"/>
        <property type="gene ID" value="ENSCJPG00005013502.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107320609"/>
    <dbReference type="KEGG" id="cjo:107320609"/>
    <dbReference type="CTD" id="27102"/>
    <dbReference type="GeneTree" id="ENSGT00940000157605"/>
    <dbReference type="OrthoDB" id="1405469at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004694">
        <property type="term" value="F:eukaryotic translation initiation factor 2alpha kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002526">
        <property type="term" value="P:acute inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051649">
        <property type="term" value="P:establishment of localization in cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140468">
        <property type="term" value="P:HRI-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030225">
        <property type="term" value="P:macrophage differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060586">
        <property type="term" value="P:multicellular organismal-level iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046986">
        <property type="term" value="P:negative regulation of hemoglobin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006909">
        <property type="term" value="P:phagocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901526">
        <property type="term" value="P:positive regulation of mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070585">
        <property type="term" value="P:protein localization to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046501">
        <property type="term" value="P:protoporphyrinogen IX metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990641">
        <property type="term" value="P:response to iron ion starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006413">
        <property type="term" value="P:translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd14049">
        <property type="entry name" value="STKc_EIF2AK1_HRI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000380">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 alpha kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000375">
        <property type="entry name" value="Putative eukaryotic translation initiation factor 2-alpha kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054521">
        <property type="entry name" value="HRI2_3H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF160">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22949">
        <property type="entry name" value="HRI2_3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="20" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-0652">Protein synthesis inhibitor</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Protein kinase" evidence="22">
        <location>
            <begin position="159"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="591"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00040433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00042456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00046654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005016423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="636" mass="71998" checksum="CD73B06AFA260310" modified="2022-01-19" version="1">MWRGREAPPRAAAHRPPPAIQFPEESPEPRFDESDVPAELRVANGSQKFVNFTSTIQNQLLLVSLLEHLCHMYTHNPVHSRCLLRILRQAFTKTGLLSPFAFCDEFSTVRLQHNRAITELMKAANRQVLNGDLDNGDSLAIREKEVLLEAQTSRYLNEFDEIARLGKGGYGQVYKVRNKLDGQFYAIKKISIKKATRRDCMKVLREVKVLAGLQHPNIVGYHTAWMEQVQTACPKDKTILKLQSLPLEQENGNDHCHIQSVESGSSIIFADLTSQEEKSGDNTYLRNPDSESVQNMDVGNDFTNSNSKEICMKPNICELPIELQEDSVSSVDCRSTDLKCDSSCGPPCSLELNDAGAGSKSCTEECSGSDVALCGEFEMEYRLMLHIQMQLCELSLWDWIAARNKRCNERTEDAAGPYHLVDVSWTMKIFEELLEGVCYIHSMGVMHRDIKPRNIFLHGSDHQVKIGDFGLACKDLLWDDADQWFHTERINGLTHTSGVGTCLYASPEQLQGSDYDFKSDMYSLGVILLELFQPFGTEMERAEVITNVRNGHVPQNFSKKWPVQAKYVKLLTSQVSAERPTAAQLRESELFHTTEHVISNLQQKVREQEEEIEKLKEKLRLLSTGQDDHMEQGSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TNJ0</accession>
    <name>A0A8C2TNJ0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Integrin beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">ITGB8</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Integrin alpha-V:beta-8 (ITGAV:ITGB8) is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligands. Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation on the surface of activated regulatory T-cells (Tregs). Required during vasculogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="18">Heterodimer of an alpha and a beta subunit. Beta-8 (ITGB8) associates with alpha-V (ITGAV) to form ITGAV:ITGB8. ITGAV:ITGB8 interacts with TGFB1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 20">Cell membrane</location>
            <topology evidence="1 20">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 20">Belongs to the integrin beta chain family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015709281.1">
        <property type="nucleotide sequence ID" value="XM_015853795.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TNJ0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005020459.1">
        <property type="protein sequence ID" value="ENSCJPP00005014362.1"/>
        <property type="gene ID" value="ENSCJPG00005011999.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107309198"/>
    <dbReference type="KEGG" id="cjo:107309198"/>
    <dbReference type="CTD" id="3696"/>
    <dbReference type="GeneTree" id="ENSGT01150000286919"/>
    <dbReference type="OrthoDB" id="410592at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034686">
        <property type="term" value="C:integrin alphav-beta8 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990430">
        <property type="term" value="F:extracellular matrix protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051216">
        <property type="term" value="P:cartilage development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033627">
        <property type="term" value="P:cell adhesion mediated by integrin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001573">
        <property type="term" value="P:ganglioside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060022">
        <property type="term" value="P:hard palate development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061520">
        <property type="term" value="P:Langerhans cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043379">
        <property type="term" value="P:memory T cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045766">
        <property type="term" value="P:positive regulation of angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009615">
        <property type="term" value="P:response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007179">
        <property type="term" value="P:transforming growth factor beta receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001570">
        <property type="term" value="P:vasculogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000076">
        <property type="entry name" value="Integrin beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000370">
        <property type="entry name" value="Integrin beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1510:FF:000010">
        <property type="entry name" value="Integrin beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1680.10:FF:000002">
        <property type="entry name" value="Integrin beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000002">
        <property type="entry name" value="Integrin beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1680.10">
        <property type="entry name" value="ligand-binding face of the semaphorins, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1510">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013111">
        <property type="entry name" value="EGF_extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057073">
        <property type="entry name" value="EGF_integrin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033760">
        <property type="entry name" value="Integrin_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015812">
        <property type="entry name" value="Integrin_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002369">
        <property type="entry name" value="Integrin_bsu_VWA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032695">
        <property type="entry name" value="Integrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057243">
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        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="INTEGRIN BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10082:SF9">
        <property type="entry name" value="INTEGRIN BETA-8"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF07974">
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    </dbReference>
    <dbReference type="Pfam" id="PF23105">
        <property type="entry name" value="EGF_integrin"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00362">
        <property type="entry name" value="Integrin_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17205">
        <property type="entry name" value="PSI_integrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002512">
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    </dbReference>
    <dbReference type="PRINTS" id="PR01186">
        <property type="entry name" value="INTEGRINB"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103575">
        <property type="entry name" value="Plexin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="vWA-like"/>
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    </dbReference>
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    </dbReference>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="11 20" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15 19" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 20" id="KW-0401">Integrin</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 22" id="KW-0732">Signal</keyword>
    <keyword evidence="5 20 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="22">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034031941" description="Integrin beta" evidence="22">
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            <begin position="17"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="681"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="23">
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            <end position="584"/>
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            <end position="420"/>
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    <feature type="disulfide bond" evidence="19">
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    <feature type="disulfide bond" evidence="19">
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    <feature type="disulfide bond" evidence="19">
        <location>
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    </feature>
    <feature type="disulfide bond" evidence="19">
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            <end position="625"/>
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        <location>
            <begin position="635"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
    <sequence length="787" mass="87175" checksum="003549353AE500AE" modified="2022-01-19" version="1">MMWVPLLACLTAGIVSVPKCQRGPGALLGAVRLLAAVPGLCQRPENRCATSNAVTCTKCLALGPECGWCAQEDFMADSTQKGRCDTVFNLLKRGCQSDFVESPTVHVTIPRDQETNTQVTPGRVSVQLRPGSEASFILKVRPLEKYPVDLYYLVDVSASMHNNIEKLNSVGFALSKKMENISLDFRLGFGSYVDKTVSPYISIHPGRIHNQCSDYNLDCMPPHGYIHVLSLTDNIAEFRNAVNKQKISGNIDTPEGGFDAMLQAAVCQSHIGWRKEAKRLLLVMTDQTSHLALDSKLAGIVIPHDGNCHLKDNVYIKATSMEHPSLGQLSEKLIDNNINVIFAVQGSQFHWYKDLLPLLPGTVARQIESQAANLNDLVVEAYQKLISEVKIQVDNQIQDLNFNITAICPDGSKKTGMEGCKNVGYNEEVLFNVSVTVKGCDTSGGRSYAILKPIGFNETTTINVQKSCACQNGNNTKPKRVWTDETFPDGKQPHCSDSSCSYSRETFPSEECRQHQDQPICSGQGDCIEGKCFCYKNKLGRVYGKYCQMDDFSCPYHQGNLCSGNGECEAGKCKCFADWEGDRCECSLQSAKQCLNSKGQICSGRGNCVCGKCECTDPRSFGRLCEFCPACNKACEENWNCVQCHHSNNASQAKLDQCKTSCAYLLHYVDQTSECFSGRSYFRVFSIIFIVTFLIGLLVVLIIRQIILQGNSNKVKSSADYRVSASKKIPLTRKRLAAPALQRGMKPKLQPLKPEEEKDPSFSHFFDTSHVYNKEKNFGNTLLLPWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TNL7</accession>
    <name>A0A8C2TNL7_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Homeobox A4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">HOXA4</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the Antp homeobox family. Deformed subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TNL7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005021424.1">
        <property type="protein sequence ID" value="ENSCJPP00005015084.1"/>
        <property type="gene ID" value="ENSCJPG00005012528.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158988"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009952">
        <property type="term" value="P:anterior/posterior pattern specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048704">
        <property type="term" value="P:embryonic skeletal system morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000419">
        <property type="entry name" value="Homeobox protein Hox-D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050609">
        <property type="entry name" value="Antp_homeobox_Deformed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45771:SF2">
        <property type="entry name" value="HOMEOBOX PROTEIN HOX-A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45771">
        <property type="entry name" value="HOMEOTIC PROTEIN DEFORMED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 9 10" id="KW-0371">Homeobox</keyword>
    <keyword evidence="7 9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="12">
        <location>
            <begin position="198"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="9">
        <location>
            <begin position="200"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="177"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="258"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="300" mass="33223" checksum="567ED7F03266A8BB" modified="2022-01-19" version="1">MSSFFDKLQLHSSPNSLPCEEYNASKSAAYRQSRLTIPHTPAPARPPPPPLRRPLRRTLARRARNRAPALTEYFPRPRREPGYQVSAGAAGAAGAPPEALYPLRHPPTPRRPTATAAPAAPPRAPSSRPRAPLRRRRRRCQGPPRAAQPLLPAMPCSARCEAAPAAGARHGPGCALLPDKSLPGTGESPGVNPNYSGGEPKRSRTAYTRQQVLELEKEFHFNRYLTRRRRIEIAHTLCLSERQVKIWFQNRRMKWKKDHKLPNTKMRSSNQPSLGQQQAKAQTQGHPRPLDGAAPNAAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TPU2</accession>
    <name>A0A8C2TPU2_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dispanin subfamily A member 2b-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC107314285</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CD225/Dispanin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015718861.1">
        <property type="nucleotide sequence ID" value="XM_015863375.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TPU2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005023422.1">
        <property type="protein sequence ID" value="ENSCJPP00005016708.1"/>
        <property type="gene ID" value="ENSCJPG00005013708.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107314285"/>
    <dbReference type="KEGG" id="cjo:107314285"/>
    <dbReference type="GeneTree" id="ENSGT00950000182857"/>
    <dbReference type="OrthoDB" id="9906841at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007593">
        <property type="entry name" value="CD225/Dispanin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051517">
        <property type="entry name" value="IFITM_antiviral_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13999">
        <property type="entry name" value="INTERFERON INDUCIBLE TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04505">
        <property type="entry name" value="CD225"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005016708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="137" mass="14962" checksum="02AAE98E9BEE581C" modified="2022-01-19" version="1">MERVRNPGPALPPYEPLMDGLDVEGKTRSTVVTMETPVVPPPRDHLAWSLCTTLYANVCCLGFLALVFSVKSRDRKVLGDYSGALSYGSTAKYLNITAHLINIFLIILVIALVASGTIVLANIFNHQQQHPDFIGPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TSB5</accession>
    <name>A0A8C2TSB5_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Structure-specific endonuclease subunit SLX1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC107321225</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Forms a heterodimer with SLX4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the SLX1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TSB5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005022490.1">
        <property type="protein sequence ID" value="ENSCJPP00005015934.1"/>
        <property type="gene ID" value="ENSCJPG00005013144.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000013368"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033557">
        <property type="term" value="C:Slx1-Slx4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10455">
        <property type="entry name" value="GIY-YIG_SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="entry name" value="GIY-YIG endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03100">
        <property type="entry name" value="Endonuc_su_Slx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027520">
        <property type="entry name" value="Slx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048749">
        <property type="entry name" value="SLX1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050381">
        <property type="entry name" value="SLX1_endonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20208">
        <property type="entry name" value="STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20208:SF10">
        <property type="entry name" value="STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21202">
        <property type="entry name" value="SLX1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2 8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIY-YIG" evidence="9">
        <location>
            <begin position="17"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="270" mass="30193" checksum="89B662B26803B48D" modified="2022-01-19" version="1">WGPRVGTGNRSGRAAMPLRAVYLLSAPGPRGRARTYVGFTHDPWRRLRQHNAGRHKGGARRTSGRGPWWMLLYVHGFPSDVAALRFEWAWQHPAASRRLQDAKPRPLPGEQPIAFALRMLPRLLWAPPWRRLPLRLRWLRPPPGPALCPAPPRHVVVEMDPGGPRPRPKQRATWGFGQGGLGSLWGPTLRCPRPPCPARCHARCLAPRFLRSEPKELLPLGGTCPCCQQEVLWGELIGHGDGDNEWADLGDPALGHWTDELLQGQGEDPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TSD3</accession>
    <name>A0A8C2TSD3_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NR LBD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TSD3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005023877.1">
        <property type="protein sequence ID" value="ENSCJPP00005017087.1"/>
        <property type="gene ID" value="ENSCJPG00005013985.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160748"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050274">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24083">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NR LBD" evidence="5">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005017087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="99" mass="11052" checksum="A2DB32EBEF6DBA94" modified="2022-01-19" version="1">AWIERRCVLMGGVLTPAPPPDAAGLSEPAHIDGVQERSQRALEEYERYRHPAQPGRFGRLLLRLPALRGVPPAAIEQLFFVRLVGKTPIETLIRDMMLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TSD5</accession>
    <name>A0A8C2TSD5_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">FAD-dependent oxidoreductase domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">FOXRED2</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Probable flavoprotein which may function in endoplasmic reticulum associated degradation (ERAD). May bind non-native proteins in the endoplasmic reticulum and target them to the ubiquitination machinery for subsequent degradation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with SEL1L. May interact with OS9 and DNAJC10. Interacts with TXNDC16.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the FOXRED2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015717642.1">
        <property type="nucleotide sequence ID" value="XM_015862156.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TSD5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005023386.1">
        <property type="protein sequence ID" value="ENSCJPP00005016673.1"/>
        <property type="gene ID" value="ENSCJPG00005013675.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107313686"/>
    <dbReference type="KEGG" id="cjo:107313686"/>
    <dbReference type="CTD" id="80020"/>
    <dbReference type="GeneTree" id="ENSGT00640000091519"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000143">
        <property type="entry name" value="FAD-dependent oxidoreductase domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050982">
        <property type="entry name" value="Auxin_biosynth/cation_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539:SF23">
        <property type="entry name" value="FAD-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_4G09220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13738">
        <property type="entry name" value="Pyr_redox_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034595089" description="FAD-dependent oxidoreductase domain-containing protein 2" evidence="12">
        <location>
            <begin position="22"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00056122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00063390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005016673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="680" mass="77382" checksum="39F87D8130B27FC0" modified="2022-01-19" version="1">MARGILLRIVLSALCAAGAAAFLYHDYCVLGAGPAGLQAAYFLQRAGRDYVVFERSHAPGSFFAIYPRHRKLISINKRHTGKANSEFNLRHDWNSLLSHEPRLLFRRYSRQFFPHADAMVRYLEDFAAFLGLHILYDTAIVHVTLEKDPQAWNGHYFVLSDQNKQSYKCSCLLVATGTWVPNVVNFPGSEYVEGYETVSTNPEDFAGQTVLILGRGNSAFETAENILGVTNFIHMVSRSRVRLSWATHYVGDLRAINNGLLDTYQLKSLDGLLEGDLEDLAIVKDKKGKLHITLRFYLENSNTSAGIDGITLPQDELDNFATRAPYDRVIRCLGWKFDFSIYNRSLRMMPGRGNKSKYPQIKPSYESRGTRGLFVLGTASHSVDFRKSAGGFIHGFRYTTRAVHRLLENRHHGVPWPSSVYPITQLTNSIIKRVNEASGLYQMFSVLADIILLRENATSFEYLEEYPVGILAELETQTGRKAPSGLFVVIMEYGRNFSGDDKDVFYYNRAVGEAQHAWQSNFLHPVIYYYKRLPTEREMRLHPPDWPLPRPDAIHHIVEDFLTDWTAPNAHILPLRRFLENCLSTDLRNFFAESCFLFVLTHQKLPPFCQQGYARMQGLAGSERLRRHAVDAGLLEDYAVTGLSGDKLPDSRQGSQDQLLRDHVIPLRPLHHLVNAKDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TSP0</accession>
    <name>A0A8C2TSP0_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AT-hook containing transcription factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">AHCTF1</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015713070.1">
        <property type="nucleotide sequence ID" value="XM_015857584.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015713071.1">
        <property type="nucleotide sequence ID" value="XM_015857585.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015713073.1">
        <property type="nucleotide sequence ID" value="XM_015857587.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005023553.1">
        <property type="protein sequence ID" value="ENSCJPP00005016826.1"/>
        <property type="gene ID" value="ENSCJPG00005013799.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107311239"/>
    <dbReference type="KEGG" id="cjo:107311239"/>
    <dbReference type="CTD" id="25909"/>
    <dbReference type="GeneTree" id="ENSGT00390000018900"/>
    <dbReference type="OrthoDB" id="20729at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051292">
        <property type="term" value="P:nuclear pore complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032465">
        <property type="term" value="P:regulation of cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032040">
        <property type="entry name" value="ELYS-bb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052620">
        <property type="entry name" value="ELYS/MEL-28_NucAsmblyFactor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025151">
        <property type="entry name" value="ELYS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21583">
        <property type="entry name" value="ELYS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21583:SF8">
        <property type="entry name" value="PROTEIN ELYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13934">
        <property type="entry name" value="ELYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16687">
        <property type="entry name" value="ELYS-bb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELYS beta-propeller" evidence="5">
        <location>
            <begin position="1"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="ELYS-like" evidence="4">
        <location>
            <begin position="722"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1349"/>
            <end position="1516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1619"/>
            <end position="1649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1765"/>
            <end position="1839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1870"/>
            <end position="2116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2159"/>
            <end position="2275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1356"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1371"/>
            <end position="1388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1393"/>
            <end position="1404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1422"/>
            <end position="1443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1476"/>
            <end position="1494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1498"/>
            <end position="1515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1637"/>
            <end position="1649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1779"/>
            <end position="1788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1790"/>
            <end position="1799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1815"/>
            <end position="1829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1919"/>
            <end position="1933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="2017"/>
            <end position="2029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="2030"/>
            <end position="2045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="2195"/>
            <end position="2213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="2240"/>
            <end position="2255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005016826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="2275" mass="253941" checksum="70FBDD16C861A6D3" modified="2022-01-19" version="1">MQDLRAQVTSSLLQFPEVTIQALGEDEITLDSVLRGKFSGGRNGLAWLACGPQLEVVNSVTGERLSAYRFSGVNEQPPTVRVVKEFSWQKRTGLLVGLEEAEGSVLCLYDLGISRVVKAVVLPGRVTAIEPIINHGGASVSTQHLHQSLRWLFGVAAVVTDVGHVLLVDLCLDDLSCSQNEVEASDLEVVTGIPAEVPQRREAVTREGRHLCFQVQNPSGTAIPTLCYISRSNLLVVGFSDGYLSLWNMKTLKREYHSQLEGGRIPVYAVTFQEPENDPRNCCYLWAVQSTQESEGDVLSLHLLQLAFGDRKRLASGQVMYEGFEYCDERYSLDLTGGAFPLRGQTSNTKLLSCQTVEKFRNHFDREDSVNEVISPDTSVSIFSWQVNTYGQGRPSTYLGVFDINRWYHAQMPDSLRPEEFLHNCSYFALWSLDAVTSVTSPNIILDVLVHERTLSRGVPPSYPPPEQFFNPSTYNFDGTCLLNSGVVHMTCTGFQKETLNFLKKSGPSISEAICDSYNRCLVAGLLSPRLVDVQPSSLSQEEQLEAVLSAAVQTSSLELLTGYIKHWTSEEQPSSAASLRFVLEWTWNKVIYTKDEFDQICVPLFDGSCNFIDPQTMQSLQHCQLVLSNLSTVLNCFLTEARELTEKGITDLTNKQVVTSLISLYAQVVIWFCRSSLLPEGLDDDMHLSRPFYNYSLIQSYYTSHRQKLERLSRGRWDSDCLMIDGMVSQLGEQAEKLWRRDEGGTGKYPPASLHALLDLYLLENIEENYKHAITIYLLLDIMHSFPNKTETSIDSFPTVFAIPWGLVKLIQGFWLLDHNDFENSLALLFHPATIKTMPWQHMRIIQSLMCQGEHRRALRYMQMMKPAMSSSSEVQLFLTVLLSNRCMVEAWSLLQQHSTKLNVEELLKHMYEICQEMGLMEDLLKLPFTDTEQECLEKFLQTNGGVQNHEFLLVHHLQRANYIPALQLNHSMKVNLMNDRDPRLRERAVARNSILDQYGKILPRVQRKLALERAKPYRLPSSVFREVSRPKPLSTVAKQANAGNVHTRATFISNVLSKIGEVWVGNEQKSSISQHDSPRVAEPPVITHPLPDAELPDAFVGTPITKFSRKCSRLLDLVVRPVPSCSPAQNDSWQSPCLPSTSYMESSSLKSNVHGSSSQKKFSRASELNLLETPLVVKRAKVLVTSSSASGFAGFTPQSILRSSLRTTPLATPSASPGRSVTPPLRAKEPRISFREVNSNAKWTVEVTEDDKAQSGASSEHCDGLVEDNWSGSRDKAPLFTLSNPEVDRSAMEESQESIPGDGLEKMDVSKEHSNVSVKSDQTTLEYHDAKSPSDFEDDVIFIAAKPASSFTEESADFQEPEKEDNEIAEDKLSQVEHTDSSELGKEAGFLEETTPECPTLPEDGKLVFKAAEAVTSQTSREDEITHEEPKMSSTPEEKDTLAVTNPQLSESPVADSESAVSVLDSEDVISTRSENHPEEKLVDLPEERNLENEAEVNTSFPQQEIHNSNNLPKTEEINVLEEVAVKAQTSEESPEISPCRELHPSGNLQYNYDTIEQQFACDLPDNKDGDCYAVEGDGELFISQSNFTLVLEGEEGKGEMGDLALADASKAAVTTTDEKPVNSLGSTENEEHVTNSVSTVTSDQESQNIAESLPYVPEPIKVAIAENLLDVIKDTRSKEFTSEVVEQSIHESIGKKVTRFRKSKTPLTAVPAEADDETSIHQVEYVVTPRTRARRQLTRTLIIPSADDERILKTDKPVLFGLSPRRSTRQTKEASETSSLVTVENTQDERIPDTPRRRGRKPKQTNLEKVESSQSDGQTLSSSTQSIAVTPRRSRRVKEAASELLEDANREMSLAEGTVIASTTSRWTRGGKSLVGEQETGQSSTDHRIKMAVSPSRSARKLKSSTSPLAKNTLMGQELQPAGQLLLPGPTKRGRRSKMSSSDVSENSDLDLSKSSLPQTEMKLPVTPRRSARKAAQNLSADMESVSAREHPPSGGEVEILDTPRRRTRKLAHTKPEKTDTIEKTPEQPNEQSTTPRTTIRSGTRGRKRRLPSILEENTREEVFPEEPDGSPLLLTDINTAGYDETSRTVTDPVRRNRSRKTRVHQELSVEENESFFFSPPLTKLTKKFKAGKADQHLEDLDPDLSSQFVFSPPLLRSRRKSVSSTPQKVEEPALPTTEEEDIKSIESVGKQKLKRGRPAVSKVKKASRSSRKEVSWSPPPVEIKFISPFGTPVDEMNSKQKETADATEKTVRKNKKRLSNLPKPVVRRKML</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TSV9</accession>
    <name>A0A8C2TSV9_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Lysophosphatidylcholine acyltransferase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LPCAT1</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the recoverin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TSV9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005025324.1">
        <property type="protein sequence ID" value="ENSCJPP00005018187.1"/>
        <property type="gene ID" value="ENSCJPG00005014813.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234574"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047184">
        <property type="term" value="F:1-acylglycerophosphocholine O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047192">
        <property type="term" value="F:1-alkylglycerophosphocholine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047191">
        <property type="term" value="F:1-alkylglycerophosphocholine O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047159">
        <property type="term" value="F:plasmalogen synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001246">
        <property type="term" value="P:negative regulation of phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036151">
        <property type="term" value="P:phosphatidylcholine acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045732">
        <property type="term" value="P:positive regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060041">
        <property type="term" value="P:retina development in camera-type eye"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043129">
        <property type="term" value="P:surfactant homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF178">
        <property type="entry name" value="NEUROCALCIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="82"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="153"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="211"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005018187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="236" mass="26672" checksum="DAD8503401CF9B30" modified="2022-01-19" version="1">MAEALGVPVTDYTFEDCQLALAEGQLRLPSDTCLLEFAKLVRSLGLKPETLEDDLDKYATRAMKMKKEKADLKEFSAYLEFPVSHTLESMFALFDENEDGIIDVREFVIALSVVCKPSKTLETIQLAFQLYQSENGTITEEDLGHILKTAMGVSQIDVTHLFRAVDEEEKGKITYDDFYRFAELQPHFAEDYLYPDQMVAESGLKTSSLSAPNGICTDFSPENAEDKNKPLQKKWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TSX4</accession>
    <name>A0A8C2TSX4_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Josephin-1</fullName>
            <ecNumber evidence="4">3.4.19.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Josephin domain-containing protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Josephin domain-containing protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Josephin-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">JOSD1</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Cleaves 'Lys-63'-linked poly-ubiquitin chains, and with lesser efficiency 'Lys-48'-linked poly-ubiquitin chains (in vitro). May act as a deubiquitinating enzyme.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Deubiquitinates monoubiquitinated probes (in vitro). When ubiquitinated, cleaves 'Lys-63'-linked and 'Lys-48'-linked poly-ubiquitin chains (in vitro), hence may act as a deubiquitinating enzyme. May increase macropinocytosis and suppress clathrin- and caveolae-mediated endocytosis. May enhance membrane dynamics and cell motility independently of its catalytic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Interacts with beta-actin/ACTB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="4"/>
    <dbReference type="RefSeq" id="XP_015718752.1">
        <property type="nucleotide sequence ID" value="XM_015863266.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TSX4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005022813.1">
        <property type="protein sequence ID" value="ENSCJPP00005016200.1"/>
        <property type="gene ID" value="ENSCJPG00005013333.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107314223"/>
    <dbReference type="KEGG" id="cjo:107314223"/>
    <dbReference type="CTD" id="9929"/>
    <dbReference type="GeneTree" id="ENSGT00390000009228"/>
    <dbReference type="OrthoDB" id="422700at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048870">
        <property type="term" value="P:cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044091">
        <property type="term" value="P:membrane biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061024">
        <property type="term" value="P:membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.40:FF:000003">
        <property type="entry name" value="josephin-2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040053">
        <property type="entry name" value="JOSD1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006155">
        <property type="entry name" value="Josephin"/>
    </dbReference>
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        <property type="entry name" value="JOSEPHIN 1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="JOSEPHIN-1"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF02099">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50957">
        <property type="entry name" value="JOSEPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 20" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
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        <location>
            <begin position="23"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="24"/>
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        <location>
            <position position="36"/>
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        <location>
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    <feature type="active site" evidence="20">
        <location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
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    </evidence>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
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        <source>
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        <source>
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            <dbReference type="ARBA" id="ARBA00077222"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00331"/>
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    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50957"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005016200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="202" mass="23291" checksum="7FD3A0E89CEB695A" modified="2022-01-19" version="1">MSCVPWKGDKAKSESPEPPQPPPLHIYHEKQRRELCALHALNNVFQDSNAFTRETLQEIFQRLSPNTMVTPHKKSMLGNGNYDVNVIMAALQTKGYEAVWWDKRRDVNVIALSNVMGFIMNLPSSLCWGPLKLPLKRQHWICVREVGGTYYNLDSKLKMPEWIGGESELRKFLKHQLRGKNCELLLVVPEEVEAHQSWRADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TUK6</accession>
    <name>A0A8C2TUK6_COTJA</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
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            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
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            <taxon>Neognathae</taxon>
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            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
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        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
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                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
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        <scope>IDENTIFICATION</scope>
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        <scope>IDENTIFICATION</scope>
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        <property type="gene ID" value="ENSCJPG00005015144.1"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005018616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="194" mass="21922" checksum="E543207EE7BBC29D" modified="2022-01-19" version="1">MRKPIHRTAEIWGSNHFYVHPGGLSITPACPRAADVPPALPSPPFCLQKAIPHPLSTQRKPVTNYPWNVYXREDPWNVYGVSMEDPWNVYGISREDPWNVYGISMEDPWNVYGISRTLFPSGLKLYCMLLLAECGINEKTHSHEPAEYGLKHVLLPPRGSSTITPAMLLGKTPLYRSLRHLTSPFACRNHSPIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TVQ5</accession>
    <name>A0A8C2TVQ5_COTJA</name>
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        <recommendedName>
            <fullName evidence="6">SLIT-ROBO Rho GTPase-activating protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Rho GTPase-activating protein 13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">SRGAP1</name>
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    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
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    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TVQ5"/>
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        <property type="protein sequence ID" value="ENSCJPP00005019351.1"/>
        <property type="gene ID" value="ENSCJPG00005015439.1"/>
    </dbReference>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="F-BAR_srGAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04383">
        <property type="entry name" value="RhoGAP_srGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11955">
        <property type="entry name" value="SH3_srGAP1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SLIT-ROBO Rho GTPase-activating protein 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000006">
        <property type="entry name" value="SLIT-ROBO Rho GTPase-activating protein 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000005">
        <property type="entry name" value="SLIT-ROBO Rho GTPase-activating protein 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051627">
        <property type="entry name" value="SLIT-ROBO_RhoGAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035648">
        <property type="entry name" value="srGAP1/2/3_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037451">
        <property type="entry name" value="srGAP1_F-BAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14166">
        <property type="entry name" value="SLIT-ROBO RHO GTPASE ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 9 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="F-BAR" evidence="14">
        <location>
            <begin position="23"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="13">
        <location>
            <begin position="506"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="12">
        <location>
            <begin position="742"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="807"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="998"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="353"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="807"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="876"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="923"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="938"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="998"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1028"/>
            <end position="1038"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00056458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00073473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00083891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005019351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1086" mass="124159" checksum="6AF357E38F830EDB" modified="2022-01-19" version="1">MRCPVSCLLKSGEEYPQLSRMLDGIRAQLIEQQKCLEQQTEMRVQLLQDLQDFFRKKAEIEMEYSRNLEKLAERFMAKTRSTKDHQQYKKDQNLLSPVNCWYLLLNQVRRESKDHATLSDIYLNNVIMRFMQISEDSTRMFKKSKEIAFQLHEDLMKVLNELYTVMKTYHMYHAESISAESKLKEAEKQEEKQIGRSGDPVFHIRLEDRHQRRSSVKKIEKMKEKRQAKYSENKLKSIKARNEYLLTLEATNASVFKYYIHDLSDLIDCCDLGYHASLNRALRTYLSAEYNLETSRHEGLDIIENAVDSLEPRSDKQRFMEMFPTAFCPPMKFEFQSHMGDEVCQVTAQQPVQAELMLRYQQLQSRLATLKIENEEVRSKTTEATLQTIQDMVTIEDYDVSECFQHSRSTESVKSTVSETYLSKPSIAKRRANQQETEQFYFMKFREYLEGSNLITKLQAKHDLLQRALGEVIIFPSLRPPNVPPKPQKHRRSRPRSHYSAKLFNGDLESFIKVLAPATGVADLNTSYYNGHGLQHQGIFRVSGSQVEVNDIKNSFERGEDPLADDQNDHDINSVAGVLKLYFRGLENPLFPKERFNDLISCIRIDNLYERALHIRKLLLTLPRSVLIVMRYLFAFLNHLSQYSDENMMDPYNLAICFGPTLMPVPDIQDQVSCQAHVNEIIKTIIIHHEAIFPDAKELDGPVYEKCMAGDDYCDSPYSEHGTLEEVDQDASTEPHTSEDECEPIEAIAKFDYTGRSARELSFKKGASLLLYHRASEDWWEGRHNGIDGLVPHQYIVVQDMDDTFSDTLSQKADSEASSGPITEDKSSSKDMNSPTDRHSDTYLGRQRKRSEPPPPLRRPGRSSDGHCPVHPPHPLSNSSVELGSPNLATHCSPRALLQNRNLNADSPERRRRPGHGSLTNISRHDSLKKIDSPPIRRSTSSGQYTGFNDHKPLDPESIAQDIEETMNTALNELRELERQSTAKHAPDVVLDTLEQMKNSPTPATSTESLSPLHSVVLRSSEPQIRRSTSSSSDTMSTFKPMVAPRMGVQLKPPALRPKPIVLPKTNPSIGPSPPSQGPADKSCTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TX31</accession>
    <name>A0A8C2TX31_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Zic family member 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ZIC5</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GLI C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TX31"/>
    <dbReference type="Ensembl" id="ENSCJPT00005027585.1">
        <property type="protein sequence ID" value="ENSCJPP00005019963.1"/>
        <property type="gene ID" value="ENSCJPG00005016135.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154200"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000035">
        <property type="entry name" value="Zinc finger protein ZIC 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000039">
        <property type="entry name" value="Zinc finger protein ZIC 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000041">
        <property type="entry name" value="Zinc finger protein ZIC 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001330">
        <property type="entry name" value="Zinc finger protein ZIC 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043359">
        <property type="entry name" value="GLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056436">
        <property type="entry name" value="Znf-C2H2_ZIC1-5/GLI1-3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041643">
        <property type="entry name" value="Znf_ZIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718:SF4">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23561">
        <property type="entry name" value="zf-C2H2_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18366">
        <property type="entry name" value="zf_ZIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="272"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="300"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="330"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="360"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="378"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="387"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="422"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005019963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="475" mass="49059" checksum="75B5E2DC7AB4E490" modified="2022-01-19" version="1">MTRFPGPGAPHGHPPRAAHPHPGDAEPGGALTPLGPEHMAQPAALQLAPEALTAAAAAFAAPAAAAAAAAAAASTAVAYAPPAAALPGCPTGGAAGRDFLPRRDLPSSSSSAAAAVAAAAAHGTPPRLPPPPPHGVFISAAGTYGPADGAHPAAFPPPPLNGQMRPEPYGRAEPHYGPAAMQGYGPGGLGLAAGRGQPPPPGGPVGAAGAFFRYMRQPIKQELICKWIDGEPPPGGGTPCSKTFSTMHELVTHVTVEHVGGPEQSSHVCHWEECPREGKPFKAKYKLINHIRVHTGEKPFPCPFPGCGKVFARSENLKIHKRTHTGEKPFKCEFDGCDRKFANSSDRKKHSHVHTSDKPYYCKIRGCDKSYTHPSSLRKHMKIHCKSPPPSPPPAPPGYAAPGPPDVPLPPGAEPLPEPPRARAAALSPPVTDLSEWYVCQAGGGRRPRSPPSRAVSPGSEGDAPRRTSGGRAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TY36</accession>
    <name>A0A8C2TY36_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NADPH oxidase activator 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">NOXA1</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NCF2/NOXA1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015734300.1">
        <property type="nucleotide sequence ID" value="XM_015878814.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TY36"/>
    <dbReference type="Ensembl" id="ENSCJPT00005027045.1">
        <property type="protein sequence ID" value="ENSCJPP00005019536.1"/>
        <property type="gene ID" value="ENSCJPG00005015824.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107321668"/>
    <dbReference type="CTD" id="10811"/>
    <dbReference type="GeneTree" id="ENSGT00530000063843"/>
    <dbReference type="OrthoDB" id="5983572at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043020">
        <property type="term" value="C:NADPH oxidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016176">
        <property type="term" value="F:superoxide-generating NADPH oxidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010310">
        <property type="term" value="P:regulation of hydrogen peroxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060263">
        <property type="term" value="P:regulation of respiratory burst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042554">
        <property type="term" value="P:superoxide anion generation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12047">
        <property type="entry name" value="SH3_Noxa1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000212">
        <property type="entry name" value="NADPH oxidase activator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000017">
        <property type="entry name" value="NADPH oxidase regulator NoxR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051864">
        <property type="entry name" value="NCF2_NOXA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15175:SF4">
        <property type="entry name" value="NADPH OXIDASE ACTIVATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15175">
        <property type="entry name" value="NEUTROPHIL CYTOSOLIC FACTOR 2, NEUTROPHIL NADPH OXIDASE FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="6" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="SH3" evidence="8">
        <location>
            <begin position="446"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005019536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="509" mass="57084" checksum="AD00B23ABAA1BA92" modified="2022-01-19" version="1">MSYRELLRRWHRAVLLADGGDWDGALETLCGIEEPPGRICFNVGCVHLRAGRLRDAMRAFDQTVTKDNSLAVGYFQRGFVCLQLEMYEEALSDYQMAFSHLRKNPFIDYKQLGLRHILYAWEVLYSTAAVQCRLQQWQEAKDTLEKAIVWRPEGRSATLALALERVQNHLFLEPMQVPPGEFFRPRKKEVEQLDSKDFLGKPKVISSIIPNDEYIGFEPLRPQKQGFYEPSADAVRDRESGYYRVLSHYYPEGAEKLAVKASSLVFVLARGADGWATAIHDGQKLHIPTSLLEPAPKVDKWKISDGIPLPPAQLPPSRLHVKQIPESPGEENVSANDSGSQVDLEVPVTHREAPSSTDRPAVLRVRCECSVLVRAGEVPSVPALRALLRESFGQQAERGRLSYRHLDGKELGAVSGEEDLGKMWQQLTDGRITLCCQDSDSHSGRPILYRMLAQHSYPAQGPGDLEFSKGDVLDILSEVNEDWLEGHCNGKTGIFPKCFATQTSCAAFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TY82</accession>
    <name>A0A8C2TY82_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Class II histocompatibility antigen, B-L beta chain-like</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TY82"/>
    <dbReference type="Ensembl" id="ENSCJPT00005026901.1">
        <property type="protein sequence ID" value="ENSCJPP00005019425.1"/>
        <property type="gene ID" value="ENSCJPG00005015730.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183127"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042613">
        <property type="term" value="C:MHC class II protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002504">
        <property type="term" value="P:antigen processing and presentation of peptide or polysaccharide antigen via MHC class II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05766">
        <property type="entry name" value="IgC1_MHC_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.320.10:FF:000001">
        <property type="entry name" value="HLA class II histocompatibility antigen, DRB1-1 beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.320.10">
        <property type="entry name" value="Class II Histocompatibility Antigen, M Beta Chain, Chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003006">
        <property type="entry name" value="Ig/MHC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003597">
        <property type="entry name" value="Ig_C1-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050160">
        <property type="entry name" value="MHC/Immunoglobulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011162">
        <property type="entry name" value="MHC_I/II-like_Ag-recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014745">
        <property type="entry name" value="MHC_II_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000353">
        <property type="entry name" value="MHC_II_b_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19944:SF99">
        <property type="entry name" value="HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DRB1 BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19944">
        <property type="entry name" value="MHC CLASS II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07654">
        <property type="entry name" value="C1-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00969">
        <property type="entry name" value="MHC_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00407">
        <property type="entry name" value="IGc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00921">
        <property type="entry name" value="MHC_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54452">
        <property type="entry name" value="MHC antigen-recognition domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00290">
        <property type="entry name" value="IG_MHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0391">Immunity</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0491">MHC II</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034599246" evidence="11">
        <location>
            <begin position="27"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="119"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005019425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="281" mass="31419" checksum="9BFEEE3BC59B1E99" modified="2022-01-19" version="1">MGSGRVPAAVAVLVALLALGARSAYGTRPSVEGTIECHFLNGTQRVRYVDRHIYNRQQLMHFDSDVGKYVADSPLGELQAEHFNSDTEYLEYKRGQVDRYCRLNYGALEPVTAQRSVQPKVRVSALQSGSLGESDRLACYVTGFYPPEIEVKWFQNGREETERVVSTDVMQNGDWTYQVLVVLETVPRRGDSYECRVEHASLPQGISQPWEPPSDAGRSKMLTGVGGFVLGLVFLALGLFMFLRSQKGERWGAGLSLWEGGYDRSDLVSLCFRATRGHRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TYA7</accession>
    <name>A0A8C2TYA7_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">CFAP119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TYA7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005026956.1">
        <property type="protein sequence ID" value="ENSCJPP00005019461.1"/>
        <property type="gene ID" value="ENSCJPG00005015769.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154323"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032727">
        <property type="entry name" value="CLAMP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28457:SF1">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 119"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28457">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14769">
        <property type="entry name" value="CLAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005019461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="243" mass="26172" checksum="E908255D5C35DD15" modified="2022-01-19" version="1">MATAGSGEPDSCETGICQWTDLDVVAMERLQAAPTLQDRRDVLAEVLPGPPVLLDAYEAAVELGQELGLSPGPLSALLAIVRRAISMCAQTPLPDVEECYAYVSELLLRHAVHHPPVSVAVFGLTQVACIAAHLFGTVLRHAKLYAYVLTPQVCLDLTLVYVDSPEHGPEGEVPTTLPEEEGETSGNPNTEPPFQEAAVPELVQVPAEVYLSKEDVSGSLRASPRSKKHLRRSQGSRQGNKRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TZA7</accession>
    <name>A0A8C2TZA7_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Lin-7 homolog C, crumbs cell polarity complex component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LIN7C</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the lin-7 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TZA7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005026147.1">
        <property type="protein sequence ID" value="ENSCJPP00005018864.1"/>
        <property type="gene ID" value="ENSCJPG00005015312.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153222"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097025">
        <property type="term" value="C:MPP7-DLG1-LIN7 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008092">
        <property type="term" value="F:cytoskeletal protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097016">
        <property type="term" value="F:L27 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002011">
        <property type="term" value="P:morphogenesis of an epithelial sheet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007269">
        <property type="term" value="P:neurotransmitter secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06796">
        <property type="entry name" value="PDZ_Lin-7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000076">
        <property type="entry name" value="Protein lin-7 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.650">
        <property type="entry name" value="L27 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014775">
        <property type="entry name" value="L27_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004172">
        <property type="entry name" value="L27_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036892">
        <property type="entry name" value="L27_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051109">
        <property type="entry name" value="MAM_complex_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14063">
        <property type="entry name" value="PROTEIN LIN-7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02828">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00569">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101288">
        <property type="entry name" value="L27 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51022">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0965">Cell junction</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="L27" evidence="11">
        <location>
            <begin position="50"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="10">
        <location>
            <begin position="133"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005018864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="237" mass="26343" checksum="05E1804E580DFA26" modified="2022-01-19" version="1">MIAIHYINYGVLCIQNSATALTLFKKQKQTKPPVGSFQALLIMNTSFLFFSVDICRAIELLEKLQRSGEVPPQKLQALQRVLQSEFCNAVREVYEHVYETVDISSSPEVRANATAKATVAAFAASEGHSHPRVVELPKTEEGLGFNIMGGKEQNSPIYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAQGKVKLVVRYTPKVLEEMESRFEKMRSAKRRQQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TZJ5</accession>
    <name>A0A8C2TZJ5_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">GTP binding elongation factor GUF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">GUF1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.n1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion inner membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the GTP-binding elongation factor family. LepA subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015717926.1">
        <property type="nucleotide sequence ID" value="XM_015862440.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TZJ5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005029161.1">
        <property type="protein sequence ID" value="ENSCJPP00005021220.1"/>
        <property type="gene ID" value="ENSCJPG00005016982.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107313795"/>
    <dbReference type="KEGG" id="cjo:107313795"/>
    <dbReference type="CTD" id="60558"/>
    <dbReference type="GeneTree" id="ENSGT00550000074940"/>
    <dbReference type="OrthoDB" id="1074at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097177">
        <property type="term" value="F:mitochondrial ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03699">
        <property type="entry name" value="EF4_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16260">
        <property type="entry name" value="EF4_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01890">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03709">
        <property type="entry name" value="lepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000078">
        <property type="entry name" value="Elongation factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000015">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000007">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2570:FF:000001">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000004">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2570">
        <property type="entry name" value="Elongation factor 4, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00071">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006297">
        <property type="entry name" value="EF-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038363">
        <property type="entry name" value="LepA_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013842">
        <property type="entry name" value="LepA_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035654">
        <property type="entry name" value="LepA_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01393">
        <property type="entry name" value="lepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512:SF7">
        <property type="entry name" value="TRANSLATION FACTOR GUF1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512">
        <property type="entry name" value="TRANSLATION FACTOR GUF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06421">
        <property type="entry name" value="LepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="57"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="66"/>
            <end position="73"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="131"/>
            <end position="135"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="185"/>
            <end position="188"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005021220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="660" mass="74277" checksum="3D488DDFE55EEC5E" modified="2022-01-19" version="1">MALTGRTVSWWVRLRRPCPAAALRGPAVWLPTGLAACQRFYSGRDKEKIDMSAYPVESIRNFSIIAHVDHGKSTLADRLLEITGTIAKTDRNKQVLDKLQVERERGITVKAQSASLFYNYKGVNYLLNLIDTPGHVDFNYEVSRSLSACQGVLLVVDANEGIQAQTVANFYLAFEAQLEIIPVINKIDLKNADPERVEKQLEKLFDIPVDECIRISAKQGTNIEKVLEKVIEKIPPPQFNTTDPLKALVFDSTFDHYRGVIANIAIFGGEIQKGHKIVSAYSNKRYEVNEVGILTPDEQPTHKLYAGQVGYLIAGMKEVTEAQIGDTLFMYKQPVEPLPGFKSAKPMVFAGMYPVDQTEYNNLKSALERLTLNDSSVTVHRDSSLALGAGWRLGFLGLLHMEVFNQRLEQEYNTSVILTAPTVPYKAVLSSAKLIKEYGNSEITIINPAQFPDKHSVSEYLEPTVLGTIVTPQEYIGKIIVLCQDRRAVQKEMLYIDEHRVMLKYLFPLNEIVVDFYDALKSLSSGYASFDYEDAGYQAADLIKMDILINGNPIEELATITHNDKAYATGKFMCERLKDAIPRQLFEIAIQAAIGKKIIARETLKAYRKNVVAKCYGGDITRRMKLLKRQAEGKRLMRKIGNVEVPRDAFIRVLKRQPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U1A0</accession>
    <name>A0A8C2U1A0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Nuclear receptor-binding factor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">NRBF2</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in starvation-induced autophagy probably by its association with PI3K complex I (PI3KC3-C1). However, effects has been described variably. Involved in the induction of starvation-induced autophagy. Stabilizes PI3KC3-C1 assembly and enhances ATG14-linked lipid kinase activity of PIK3C3. Proposed to negatively regulate basal and starvation-induced autophagy and to inhibit PIK3C3 activity by modulating interactions in PI3KC3-C1. May be involved in autophagosome biogenesis. May play a role in neural progenitor cell survival during differentiation.</text>
    </comment>
    <comment type="function">
        <text evidence="11">May modulate transcriptional activation by target nuclear receptors. Can act as transcriptional activator (in vitro).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Autophagosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2U1A0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005027167.1">
        <property type="protein sequence ID" value="ENSCJPP00005019645.1"/>
        <property type="gene ID" value="ENSCJPG00005015906.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000000984"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035032">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.80:FF:000018">
        <property type="entry name" value="nuclear receptor-binding factor 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039679">
        <property type="entry name" value="NRBF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015056">
        <property type="entry name" value="NRBF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033393">
        <property type="entry name" value="NRBF2_MIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14964">
        <property type="entry name" value="NUCLEAR RECEPTOR BINDING FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14964:SF2">
        <property type="entry name" value="NUCLEAR RECEPTOR-BINDING FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08961">
        <property type="entry name" value="NRBF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17169">
        <property type="entry name" value="NRBF2_MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140361">
        <property type="entry name" value="MIT domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Nuclear receptor-binding factor 2 MIT" evidence="16">
        <location>
            <begin position="95"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Nuclear receptor-binding factor 2 C-terminal" evidence="15">
        <location>
            <begin position="181"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="56"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="262"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00054797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00059930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF17169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005019645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="381" mass="42117" checksum="5D5E6DE5A4ACD616" modified="2022-01-19" version="1">MALFPHFCPQIPHFERPPWLEGPRGDARAPLSRDTGCLAIRDGAVAEAAAVFTRRRGGAGGGAAPAAGPGRGTGSGEEAASAPMCPQPPQPMEVMEGPLNLAHQQSRKADRLLAAGKYEEAISCHRKAAAYLTEAMKLTQSEQAQLSLELQRDSHMKQLLLIQERWKRAKREEKMKAQQNVDKELAAHLQTSFKPSAEESDDQNVLIPVTQKYSPSTEKHLQDIQGVFDRDPDTLLFLLQKKNEPVEACIGSKAPKDDKTIIEEQATKIADLKRHVEFLVAENERLRRENKQLKAERARLQKSPVEKELDVDADFVEKSELWGLQQHSETASSAASWQEFATTAGKAKDIPIPNLPPLDIPSPELPLLELSEDILKGLMNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U1E6</accession>
    <name>A0A8C2U1E6_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Actin alpha cardiac muscle 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ACTC1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the actin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2U1E6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005030099.1">
        <property type="protein sequence ID" value="ENSCJPP00005021969.1"/>
        <property type="gene ID" value="ENSCJPG00005017536.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154710"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031674">
        <property type="term" value="C:I band"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017022">
        <property type="term" value="F:myosin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033275">
        <property type="term" value="P:actin-myosin filament sliding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055008">
        <property type="term" value="P:cardiac muscle tissue morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055003">
        <property type="term" value="P:cardiac myofibril assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060327">
        <property type="term" value="P:cytoplasmic actin-based contraction involved in cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060047">
        <property type="term" value="P:heart contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030240">
        <property type="term" value="P:skeletal muscle thin filament assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd10224">
        <property type="entry name" value="ASKHA_NBD_actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000131">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000291">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000047">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00406">
        <property type="entry name" value="ACTINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0558">Oxidation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="64"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005021969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="486" mass="53974" checksum="4107083481C590AF" modified="2022-01-19" version="1">MESPRRAPSLPSHHVGGGLPIWPCGGRTALLRTCLRWPGSRAAPCAIHGRAAPPWRRAGQIRRRWLPRPADRPAPPRAIKRQPRAPPASRRSSVTFHRPCCSGPCLSAKMCDDEETTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNTPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDEAGPSIVHRKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U228</accession>
    <name>A0A8C2U228_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Gap junction protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">GJA9</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">A connexon is composed of a hexamer of connexins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Gap junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 9">Cell membrane</location>
            <topology evidence="2 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the connexin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015739019.1">
        <property type="nucleotide sequence ID" value="XM_015883533.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015739020.1">
        <property type="nucleotide sequence ID" value="XM_015883534.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032304806.1">
        <property type="nucleotide sequence ID" value="XM_032448915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U228"/>
    <dbReference type="Ensembl" id="ENSCJPT00005027972.1">
        <property type="protein sequence ID" value="ENSCJPP00005020285.1"/>
        <property type="gene ID" value="ENSCJPG00005016355.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107323945"/>
    <dbReference type="KEGG" id="cjo:107323945"/>
    <dbReference type="CTD" id="81025"/>
    <dbReference type="GeneTree" id="ENSGT01150000286954"/>
    <dbReference type="OrthoDB" id="9939271at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005922">
        <property type="term" value="C:connexin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005243">
        <property type="term" value="F:gap junction channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007267">
        <property type="term" value="P:cell-cell signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.80:FF:000001">
        <property type="entry name" value="Gap junction alpha-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.80">
        <property type="entry name" value="Gap junction channel protein cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000500">
        <property type="entry name" value="Connexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019570">
        <property type="entry name" value="Connexin_CCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017990">
        <property type="entry name" value="Connexin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013092">
        <property type="entry name" value="Connexin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038359">
        <property type="entry name" value="Connexin_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11984">
        <property type="entry name" value="CONNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11984:SF60">
        <property type="entry name" value="GAP JUNCTION ALPHA-9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00029">
        <property type="entry name" value="Connexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00206">
        <property type="entry name" value="CONNEXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00037">
        <property type="entry name" value="CNX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01089">
        <property type="entry name" value="Connexin_CCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00407">
        <property type="entry name" value="CONNEXINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00408">
        <property type="entry name" value="CONNEXINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0965">Cell junction</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0303">Gap junction</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Connexin N-terminal" evidence="13">
        <location>
            <begin position="43"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Connexin cysteine-rich" evidence="14">
        <location>
            <begin position="167"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="318"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="430"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="111"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="318"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="343"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="353"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="462"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="483"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005020285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="511" mass="57160" checksum="29C36CE5EFBD457D" modified="2022-01-19" version="1">MGDWNFLGGILEEVHIHSTIIGKIWLTILFVFRMLVLGVATEDVWNDEQSEFICNTEQPGCSNICYDEAFPISLIRYWVLQVIFVSSPSLVYMGHALYRLRALEKERQKKKVQVRVELESTELEMTEYRRRLERELRQLDQRKLNKAPLRGSLLCTYVIHIFTRSAVEVGFMIGQYLLYGFRLDPLYKCHRDPCPNVVDCFVSRPTEKTVFILFMQSIATVSLLLNVLEIIHLGFRKIKIGLCGQEENKDDRGNFYTNKCKKYSVIPRSSLGISATPPKTLPSVLGGYAFLMEKQTDTAIYPALNSAPIFQPIQNNHAENRGNYTQHNQENKLPKKRPATNALAGQTPNASTECREGLLGRPATERRNSQKEADQKHLLAGTQNADTASRSFAEMLSQPPLQPFPVASLRRQHGIISSWNCCTAAESVGSSTNSLTKSSSRRRSSLSASQLPPKADTRHPSRPNTPDSAGEASTGSKQSRGCGSPQPLPLSGRLSLSSSASSRRAPTDLQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U6E7</accession>
    <name>A0A8C2U6E7_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Outer mitochondrial membrane lipid metabolism regulator OPA3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">OPA3</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May play some role in mitochondrial processes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OPA3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2U6E7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005033046.1">
        <property type="protein sequence ID" value="ENSCJPP00005024215.1"/>
        <property type="gene ID" value="ENSCJPG00005019116.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000009795"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019216">
        <property type="term" value="P:regulation of lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010754">
        <property type="entry name" value="OPA3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12499:SF0">
        <property type="entry name" value="OPTIC ATROPHY 3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12499">
        <property type="entry name" value="OPTIC ATROPHY 3 PROTEIN OPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07047">
        <property type="entry name" value="OPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <sequence length="266" mass="28631" checksum="9341F0AC087096ED" modified="2022-01-19" version="1">MVAGAFPIAKLLTLGARQLSRPLAARIKAGARASPFFRTYICLPPAQLYHWVEMRAKMRIMGFRGAAVKPLNEEAAAELGAELLGEAIVFGVGGLCIYMEYARQAGQSRRKEEEQAAALKNMAADIESMRRELDAILRERGGAKISHAPEQSQAANRSEAATLSHASKGQGYGVKDMGTRIWGQGHGVKDMGSRTWGHGHGDTDMGTRIWGHGHAQWGSFQPNAIMHGTSPTPSPAHGVHAPPMGRHQGTRGQGCGDKDMGTRTWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
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                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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                <consortium name="Ensembl"/>
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        <text evidence="2">Belongs to the COMM domain-containing protein 5 family.</text>
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    </dbReference>
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            <end position="217"/>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00093452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="226" mass="24827" checksum="92BD90E1421BD3BE" modified="2022-01-19" version="1">MAAVAVGKAAGAAYGHGESGGGSGGFLGPRVPAEVEAMARGLHEVGKETFRRLLKVTVNALEGKDCKEAVKLIAESTDLSEEQLAFLISGMYTLLREALRLPISTFKQEVFKEDLKELRIPEDFITDFSSIVFGNRRPASEGTALMQATRLPSVQDFKWRVDVAISTSSLARALQPSILMLMKLSDGTAHRFEVPVAKFQELRYNVALILKEMNDLEKRSVLKIQD</sequence>
</entry>
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    <accession>A0A8C2U8A2</accession>
    <name>A0A8C2U8A2_COTJA</name>
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        <submittedName>
            <fullName evidence="2">Regulator of cell cycle</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">RGCC</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
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                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:negative regulation of angiogenesis"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:negative regulation of cell-cell adhesion mediated by cadherin"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005025031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="131" mass="13739" checksum="D4841D79E33079FD" modified="2022-01-19" version="1">VGPRGGLGSPHAAVRSATAGGLAEALGEFEAVLEDFACPAGRSRFHYGEHLERMKRRSSASVSDGSGLSDSESADSLYRNSFSLSDEKLNSPTASTPSLPSPPVTPCKAKLGDTKELEEFIADLDRTLASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U8N5</accession>
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        <submittedName>
            <fullName evidence="4">FAM161 centrosomal protein B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FAM161B</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM161 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2U8N5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005033014.1">
        <property type="protein sequence ID" value="ENSCJPP00005024189.1"/>
        <property type="gene ID" value="ENSCJPG00005019101.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159998"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044782">
        <property type="term" value="P:cilium organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051655">
        <property type="entry name" value="FAM161"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019579">
        <property type="entry name" value="FAM161A/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21501">
        <property type="entry name" value="PROTEIN FAM-161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21501:SF4">
        <property type="entry name" value="PROTEIN FAM161B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10595">
        <property type="entry name" value="FAM161A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="436"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="440"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005024189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="537" mass="62832" checksum="2835CF666367C41F" modified="2022-01-19" version="1">MQLSSYCVAYSRQIYPSIPPISRSCPCPRACLLTTSSAYSVILSINRSPFFQFNFLIISLISPSSCLCLSHTSGNKRQSRSLIDLTSDSTWDQQKPHLFPKPRLRPKSASSPWIPSITIPQPFKMTLREARKKSQLMKSNMFLELDKLRDKRQSQDEVECQKQFRAQPVPAHVFLPLYHEIMEQNEVRRQIATQKRKEQLLSTQRPFSFLEKEEKKKEAIRQKFLTAAAPNESSKLKKVNRKVPRSTNDTLLGDKLEEAELYREIRIQMRAKDLLESSVAPIDTSNCRRDPQSRTATKTKQERLGFLQDRSFSFKPRINPTVPDFEELYWAFQREAVRRQEIKEATRIKPFKLRTSNLRGRQREANEKIKPLPIHSLTALCSLSSNTLPVHITDATRKREAAIRNSQESKKEGDREGIYWLEKQKKKCQAIRKSVNSRAKALDPHKSLDETHKEKLKQNRQNMRERTKEYRKELEEMQLRVKNRPYLFEQVSKHDARQGAERRYRHTLQQVGLSEEFVRKKGKDAADLLEEESDVHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U9C2</accession>
    <name>A0A8C2U9C2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 7">BH3-interacting domain death agonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BID</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Induces caspases and apoptosis. Counters the protective effect of BCL2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Forms heterodimers either with the pro-apoptotic protein BAX or the anti-apoptotic protein BCL2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2U9C2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005032426.1">
        <property type="protein sequence ID" value="ENSCJPP00005023698.1"/>
        <property type="gene ID" value="ENSCJPG00005018755.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000166408"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001238">
        <property type="term" value="P:positive regulation of extrinsic apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001244">
        <property type="term" value="P:positive regulation of intrinsic apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090200">
        <property type="term" value="P:positive regulation of release of cytochrome c from mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001836">
        <property type="term" value="P:release of cytochrome c from mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.437.10:FF:000010">
        <property type="entry name" value="BH3-interacting domain death agonist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.437.10">
        <property type="entry name" value="Blc2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036834">
        <property type="entry name" value="Bcl-2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010479">
        <property type="entry name" value="BID"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35447">
        <property type="entry name" value="BH3-INTERACTING DOMAIN DEATH AGONIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35447:SF1">
        <property type="entry name" value="BH3-INTERACTING DOMAIN DEATH AGONIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06393">
        <property type="entry name" value="BID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038018">
        <property type="entry name" value="BID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56854">
        <property type="entry name" value="Bcl-2 inhibitors of programmed cell death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 7" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00015802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR038018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005023698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="216" mass="24295" checksum="55371F2F46F35EEE" modified="2022-01-19" version="1">MEQDIYSDGSDRVERMLLFAFLDVKSSGCEFREQLPLLQKQSILRSAKEVQCYDSDGELQTDGNRSGHLQNGELVLDPEVNEEVVRTIAAQLAEIGDQLDKQIRAKVVNDLVQHFRNENLPREEITRYLSQAVEGLARAIPSDLEQEKAMLVLAMLLTKKVANQVPSLLQRVFSTTVNYINQHLHNYVVRMVCAIQQLCSSAQVTAQVSLLALVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UBD7</accession>
    <name>A0A8C2UBD7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2UBD7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005032823.1">
        <property type="protein sequence ID" value="ENSCJPP00005024032.1"/>
        <property type="gene ID" value="ENSCJPG00005018989.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162998"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002376">
        <property type="term" value="P:immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009617">
        <property type="term" value="P:response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052051">
        <property type="entry name" value="TCR_complex_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19433:SF111">
        <property type="entry name" value="T CELL RECEPTOR ALPHA VARIABLE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19433">
        <property type="entry name" value="T-CELL RECEPTOR ALPHA CHAIN V REGION-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0391">Immunity</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005024032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="187" mass="20644" checksum="20FD8E0E32446E53" modified="2022-01-19" version="1">KELSQQSLSSPLTQTSEGTGINITCSHPKIQINDYIHWYRQLPDRGPAFIVSVFKGSKEVPDPEGRLLVSADRRSSALWLARPRLADAAVYYCAVGTRGVEPGLRPDTNRFGRGGAPWFPGPQGAMRHLRLGPPELTVLTWRMSLAMLGILWNKAFQLHTSMSAACRGHKHLPVVPTVSLSSDYEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UCA3</accession>
    <name>A0A8C2UCA3_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Growth/differentiation factor 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Bone morphogenetic protein 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">GDF5</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Growth factor involved in bone and cartilage formation. During cartilage development regulates differentiation of chondrogenic tissue through two pathways. Firstly, positively regulates differentiation of chondrogenic tissue through its binding of high affinity with BMPR1B and of less affinity with BMPR1A, leading to induction of SMAD1-SMAD5-SMAD8 complex phosphorylation and then SMAD protein signaling transduction. Secondly, negatively regulates chondrogenic differentiation through its interaction with NOG. Required to prevent excessive muscle loss upon denervation. This function requires SMAD4 and is mediated by phosphorylated SMAD1/5/8. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the TGF-beta family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015736826.1">
        <property type="nucleotide sequence ID" value="XM_015881340.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UCA3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005035736.1">
        <property type="protein sequence ID" value="ENSCJPP00005026396.1"/>
        <property type="gene ID" value="ENSCJPG00005020522.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107322835"/>
    <dbReference type="KEGG" id="cjo:107322835"/>
    <dbReference type="CTD" id="8200"/>
    <dbReference type="GeneTree" id="ENSGT00940000160455"/>
    <dbReference type="OrthoDB" id="5987191at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036122">
        <property type="term" value="F:BMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030509">
        <property type="term" value="P:BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060591">
        <property type="term" value="P:chondroblast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002062">
        <property type="term" value="P:chondrocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030326">
        <property type="term" value="P:embryonic limb morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035136">
        <property type="term" value="P:forelimb morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035137">
        <property type="term" value="P:hindlimb morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097152">
        <property type="term" value="P:mesenchymal cell apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032331">
        <property type="term" value="P:negative regulation of chondrocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050680">
        <property type="term" value="P:negative regulation of epithelial cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001054">
        <property type="term" value="P:negative regulation of mesenchymal cell apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030513">
        <property type="term" value="P:positive regulation of BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032332">
        <property type="term" value="P:positive regulation of chondrocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060391">
        <property type="term" value="P:positive regulation of SMAD protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040014">
        <property type="term" value="P:regulation of multicellular organism growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd19399">
        <property type="entry name" value="TGF_beta_GDF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.90.10:FF:000001">
        <property type="entry name" value="Bone morphogenetic protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.970:FF:000011">
        <property type="entry name" value="Growth/differentiation factor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001839">
        <property type="entry name" value="TGF-b_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001111">
        <property type="entry name" value="TGF-b_propeptide"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015615">
        <property type="entry name" value="TGF-beta-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017948">
        <property type="entry name" value="TGFb_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848:SF44">
        <property type="entry name" value="GROWTH_DIFFERENTIATION FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848">
        <property type="entry name" value="TGF-BETA FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00019">
        <property type="entry name" value="TGF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00688">
        <property type="entry name" value="TGFb_propeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00669">
        <property type="entry name" value="INHIBINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00204">
        <property type="entry name" value="TGFB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00250">
        <property type="entry name" value="TGF_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51362">
        <property type="entry name" value="TGF_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 15" id="KW-0339">Growth factor</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034614764" description="Growth/differentiation factor 5" evidence="17">
        <location>
            <begin position="28"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="TGF-beta family profile" evidence="18">
        <location>
            <begin position="377"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="28"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="65"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="150"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
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            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
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        </source>
    </evidence>
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        </source>
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    <evidence type="ECO:0000256" key="13">
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            <dbReference type="ARBA" id="ARBA00072959"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
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            <dbReference type="PROSITE" id="PS51362"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005026396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="500" mass="55975" checksum="A570A481589D73E0" modified="2022-01-19" version="1">MKILHFLTLLLWHLTWLSLDLVPGALSNSEAGQSNPGSKTDLLKAEGKERTPSARAGTPRAANHGFSTGTSKARTKSNAAQPGALLAKNDESQRVLSRAAASEAKVGHLPSRPSGVRTVTPKVPNLSSKTALKKPSTSSADSSAFKTKKTKEPVTQREAKEAFRQPPITPHEYMLSLYRTLSDAERKGVNGSVKLEAGLANTITSFIDKGQDERAPTIRKQKYIFDISALEKDGLLGAELRILRKKPSDAWKSHSSGKTSQVKLFSCSTNRQAATLLDSRIVSITDTPKWEVFDIWKLFRNFKNLVNLCFELETFDRGRAVDLRTVGFNRTGRQVNEKALFLVFGRTKKRDLFFNEIKARSGQDDKTVYEYLFNQRRKRRAPLATRQGKRPSKNLKARCSRKALHVNFKDMGWDDWIIAPLEYEAYHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISILFIDSANNVVYKQYEDMVVESCGCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UCE4</accession>
    <name>A0A8C2UCE4_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoinositide-3-kinase regulatory subunit 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">PIK3R6</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015735652.1">
        <property type="nucleotide sequence ID" value="XM_015880166.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015735653.1">
        <property type="nucleotide sequence ID" value="XM_015880167.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015735654.1">
        <property type="nucleotide sequence ID" value="XM_015880168.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UCE4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005035794.1">
        <property type="protein sequence ID" value="ENSCJPP00005026443.1"/>
        <property type="gene ID" value="ENSCJPG00005020558.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005035795.1">
        <property type="protein sequence ID" value="ENSCJPP00005026444.1"/>
        <property type="gene ID" value="ENSCJPG00005020558.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005035796.1">
        <property type="protein sequence ID" value="ENSCJPP00005026445.1"/>
        <property type="gene ID" value="ENSCJPG00005020558.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107322277"/>
    <dbReference type="KEGG" id="cjo:107322277"/>
    <dbReference type="CTD" id="146850"/>
    <dbReference type="GeneTree" id="ENSGT00530000063753"/>
    <dbReference type="OrthoDB" id="8781591at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005944">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class IB"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046935">
        <property type="term" value="F:1-phosphatidylinositol-3-kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046934">
        <property type="term" value="F:1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045766">
        <property type="term" value="P:positive regulation of angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045582">
        <property type="term" value="P:positive regulation of T cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042269">
        <property type="term" value="P:regulation of natural killer cell mediated cytotoxicity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019522">
        <property type="entry name" value="PIK3R5/6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15593">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15593:SF1">
        <property type="entry name" value="PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10486">
        <property type="entry name" value="PI3K_1B_p101"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005026444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="762" mass="85207" checksum="9985875ACB65B51C" modified="2022-01-19" version="1">MLCCSPGPAMESAELESDILRRVRTLLRELDGHHPACQRDRGMLRWTLHKKIDQNPSNSPILVRILVKELERAERGDYRHYIIPLLHTLMYALIKAPCISDELCSRVYDFCKKLLTLPKPFCTIGLDYAARLKMERTAPGMLYQRMVISEQSLRSEPYPYQEKIFIFADPELLSEAICKALLTDTEAARVSQSPRACMCHVITHAMQAALGEGCDLSALRMRLQGMPSSEVEHWFQEVVTTVECTGSKGGADRRQHTERLRSIYSAILSSSPPGNAPLEGLQGTPLPNPNISFHLWTEDDQLWKELVLFIRPLSQSCEPDRLSQDLDNFEIQDIISDCECCEQTRFSVLSTDSGIERDLPPTAEEPFAPCSADTEQSRLHRKGGIKKKPSPLESVAFLQTGCNSPGVKPAAKVQKRVGIPTEPTAPLLRLHTARIVLLGDDRILGRLAQAYHSLRKRETRRVFLTPRLNLQFYYVPVTGQPGTLADANPSATSPEELCEVAAYLSRADPWYESNINTLCHMIPKLAAMPSSPSKHLVTDLFITDVIAYYVRMGAQPICFQVYAVKVFFSSSAQEPAEDVFLTELCAQVQDSISPREVNPTKKKTTLDGPGIDLTVTYRKVVVSDRAKEVSLSLRSTGLSMKAIPASSAEDLECLNVNITEAVRINNLSGRSFSTVANKLKTRNIKISSTEQRPFTLCLDKDSRRTYRSVISLEVSPCLEPSYCLQKSRTMKFSLHEAEDVGIVKYMPKSLLLPINTFAGVIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UD03</accession>
    <name>A0A8C2UD03_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AarF domain containing kinase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ADCK2</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015722349.1">
        <property type="nucleotide sequence ID" value="XM_015866863.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UD03"/>
    <dbReference type="Ensembl" id="ENSCJPT00005035220.1">
        <property type="protein sequence ID" value="ENSCJPP00005025947.1"/>
        <property type="gene ID" value="ENSCJPG00005020282.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107315915"/>
    <dbReference type="KEGG" id="cjo:107315915"/>
    <dbReference type="CTD" id="90956"/>
    <dbReference type="GeneTree" id="ENSGT00390000001536"/>
    <dbReference type="OrthoDB" id="427480at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010795">
        <property type="term" value="P:regulation of ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd13971">
        <property type="entry name" value="ADCK2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044095">
        <property type="entry name" value="ADCK2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052402">
        <property type="entry name" value="ADCK_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45890:SF1">
        <property type="entry name" value="AARF DOMAIN CONTAINING KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45890">
        <property type="entry name" value="AARF DOMAIN CONTAINING KINASE 2 (PREDICTED)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034311170" evidence="2">
        <location>
            <begin position="21"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="3">
        <location>
            <begin position="304"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005025947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="623" mass="69186" checksum="AC98355D3661D537" modified="2022-01-19" version="1">MVAGCAARLLPLPLLGRAAGARGPPPGWAVLGRVGLRAGRWAAVALAVPAAAGRREEPVRWRAAALPVWAGERGPERPARGVLRRLRLVLRLGLRACGLLLRFGPLLLLYPLSRLRPGMAALWLRLLRRAAEAAGPTCIKLGQWASTRRDLFSEAFCDEFSKLHVEVSPHPWGHTDELLRKAFGEDWRRILTFPSQEPVGSGCVAQVYKAYADLTAIAGPPAEGLAWSSELQSAFEAWEVSGLRGLFRWLRRKSERMWEERSGAELSPISCSLRNPVHGTPRVEQTATQLLDANPSPARPLTPVAVKVLHPGLVQQVQMDLFLMKLGSHIIGLLPGFKWLSLTEIVEEFEKLMLQQIDLHYEARNLERFRQNFLDVNFVKFPTPVRPLVTTDVLVETFEESEPISHYLHTEVATELRQRLAKMGMDMLLKMVFVDNFVHADLHPGNILVQGTACVSTSYKEQTAIVDLCDTLIVEVQPPFKQLCLVLLDAGIVAELQSADMQNFRAVFTAVVQGQGEKVAELILHHARANQCQDIERFKAEMAELVTKVRRNTIALGKLQVANLLSSVFKLLMTHKVKLESNFASIIFAIMVLEGLGRSLDPELDILEAAKPLLIRTAASVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UE16</accession>
    <name>A0A8C2UE16_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">RNA binding motif protein 20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">RBM20</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2UE16"/>
    <dbReference type="Ensembl" id="ENSCJPT00005034711.1">
        <property type="protein sequence ID" value="ENSCJPP00005025534.1"/>
        <property type="gene ID" value="ENSCJPG00005020031.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234642"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036464">
        <property type="term" value="C:cytoplasmic ribonucleoprotein granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097157">
        <property type="term" value="F:pre-mRNA intronic binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990935">
        <property type="term" value="F:splicing factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060914">
        <property type="term" value="P:heart formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048025">
        <property type="term" value="P:negative regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033120">
        <property type="term" value="P:positive regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160091">
        <property type="term" value="P:spliceosome-depend formation of circular RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd12685">
        <property type="entry name" value="RRM_RBM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034790">
        <property type="entry name" value="RBM20_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15592">
        <property type="entry name" value="MATRIN 3/NUCLEAR PROTEIN 220-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="398"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Matrin-type" evidence="9">
        <location>
            <begin position="1047"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="135"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="245"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="502"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="614"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="664"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="876"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="502"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="517"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="529"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="563"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="621"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="664"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="723"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="735"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="776"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="887"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="908"/>
            <end position="944"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005025534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1113" mass="123788" checksum="56F97C1B0837B8B1" modified="2022-01-19" version="1">MSQPLFNQLRHPSVMGAPPGHAAGGPPPGPGITSTRFSSGGIAFPAQSTGGSLGPVQAQAPNAIVMSPFGGVMAPTSSQQPVVVGLNKVGPSAAAAAGGFYEYSKQNVTAPQVYTSDGDQPGFPSAVGARYDGPFGSAGPLKHDAPTGFQKDTYGAAPAFPGDPHTGAHPKGDPSPILHGTGTSNQWENIPNFSSQNKSDLLPSDSMWPSASQQPYEIRNELYNPEEPTPDTKFSTAAAPAFGRLNNSKQSFGSPRLRQNEELSTGAPDLPMRSLQPHELNDLHGVAPLHFPHVCSLCDKKIFDLKDWDQHVKGTLHIQKCMAFSDNTGIRCVLSSSDGTLHISPNSAAVFNPSSIEDYPPNVGSSFITTSARSFGQPGATFPSLPSGFPQRKSTLGRVVHICNLPEGSCTENDVINLGLPFGKVTNYILMKSTNQAFLEMAYSEAAQAMVQYYKEKPAMINDDKLLIRMSKRYKELQLKKPGKNVAAIIQDIHSQRERDLLREADSRYGTERPRSRSPISRSLSPRSHTPSFTSCSSPRSPMGTSRTDWGNGRESWDQSPYSRREEERESREWRENGDEKRDRTDTWVHERKHYSRQLDKFDLDERIEGGRGHREKYIRSGSPGSLHPLSGYKSREDDYYRKASKSKCDKFQRQEFSGRFKRKEEAKFREHRHSYSEDAAREEVAEQKHNKVSESSRQKQSDKNRVKKAEKDQEEDAVAEGSDVKETKPPENKVSGNTVALVFQSISSLGKEEQDPEKSSPSADKQGGESGETLENTRKEKDQDWESGSEIEGETWYPANMEELVTVDEVGEDDLIMEPDITELEEIVPVDQKSKAATEMCSCMTTMLELENNHSHLTRSEEKFTHKPLETNFRSAKGSVASSICQDDEEDDNDDAVTEASSLNLDPEQKPEESQEDQSAKESDHQQKEVKNDKGSDTHLEPSVQLKEEALQLPGAFIDDYKQMGSQGAESREVMEMLVKNVSEETRHGSQECPEANSRYLEMRSLEYPEVESRRRHSPAGWEQEDVFTELSIPLGVEFVVPRTGFYCKLCGLFYTNEETAKTNHCRSTVHYKNLQKYLSQLAEESLKMKEEDSHLLQDDTGIVPHFTKKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UFN1</accession>
    <name>A0A8C2UFN1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="43">Triacylglycerol lipase</fullName>
            <ecNumber evidence="43">3.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="43">Pancreatic lipase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="45" type="primary">LOC107316185</name>
    </gene>
    <organism evidence="45 46">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="45" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="45" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="45" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>(9Z-octadecenoyl)-glycerol + H2O = glycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:39955"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:75937"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:39956"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = di-(9Z)-octadecenoylglycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38575"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:53753"/>
            <dbReference type="ChEBI" id="CHEBI:75945"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="31">
            <dbReference type="Rhea" id="RHEA:38576"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>1,2,3-tributanoylglycerol + H2O = dibutanoylglycerol + butanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40475"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17968"/>
            <dbReference type="ChEBI" id="CHEBI:35020"/>
            <dbReference type="ChEBI" id="CHEBI:76478"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="30">
            <dbReference type="Rhea" id="RHEA:40476"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="35">
            <text>1,2,3-trioctanoylglycerol + H2O = dioctanoylglycerol + octanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:47864"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25646"/>
            <dbReference type="ChEBI" id="CHEBI:76978"/>
            <dbReference type="ChEBI" id="CHEBI:88066"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="35">
            <dbReference type="Rhea" id="RHEA:47865"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>1,2,3-tripropanoylglycerol + H2O = dipropanoylglycerol + propanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48024"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17272"/>
            <dbReference type="ChEBI" id="CHEBI:88153"/>
            <dbReference type="ChEBI" id="CHEBI:88155"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:48025"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>1,2-didecanoylglycerol + H2O = decanoylglycerol + decanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48596"/>
            <dbReference type="ChEBI" id="CHEBI:11152"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:27689"/>
            <dbReference type="ChEBI" id="CHEBI:90605"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:48597"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>1,2-didodecanoyl-3-O-[alpha-D-galactosyl-(1-&gt;6)-beta-D-galactosyl]-sn-glycerol + H2O = dodecanoyl-3-O-[alpha-D-galactosyl-(1-&gt;6)-beta-D-galactosyl]-sn-glycerol + dodecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48516"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18262"/>
            <dbReference type="ChEBI" id="CHEBI:90337"/>
            <dbReference type="ChEBI" id="CHEBI:90359"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:48517"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="37">
            <text>1,2-didodecanoyl-3-beta-D-galactosyl-sn-glycerol + H2O = dodecanoyl-3-beta-D-galactosyl-sn-glycerol + dodecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48540"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18262"/>
            <dbReference type="ChEBI" id="CHEBI:90340"/>
            <dbReference type="ChEBI" id="CHEBI:90515"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="37">
            <dbReference type="Rhea" id="RHEA:48541"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="33">
            <text>1,2-dioctanoyl-3-O-[alpha-D-galactosyl-(1-&gt;6)-beta-D-galactosyl]-sn-glycerol + H2O = octanoyl-3-O-[alpha-D-galactosyl-(1-&gt;6)-beta-D-galactosyl]-sn-glycerol + octanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48692"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25646"/>
            <dbReference type="ChEBI" id="CHEBI:90457"/>
            <dbReference type="ChEBI" id="CHEBI:90768"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="33">
            <dbReference type="Rhea" id="RHEA:48693"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>1,2-dioctanoyl-3-O-beta-D-galactosyl-sn-glycerol + H2O = octanoyl-3-(beta-D-galactosyl)-sn-glycerol + octanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48696"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25646"/>
            <dbReference type="ChEBI" id="CHEBI:90453"/>
            <dbReference type="ChEBI" id="CHEBI:90769"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="29">
            <dbReference type="Rhea" id="RHEA:48697"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>1-(9Z-octadecenoyl)-glycerol + H2O = glycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38487"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:75342"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:38488"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>1-beta-D-galactosyl-2,3-didodecanoyl-sn-glycerol + H2O = 1-beta-D-galactosyl-dodecanoyl-sn-glycerol + dodecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48536"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18262"/>
            <dbReference type="ChEBI" id="CHEBI:90342"/>
            <dbReference type="ChEBI" id="CHEBI:90514"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:48537"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + 2 H2O = 3-beta-D-galactosyl-sn-glycerol + 2 a fatty acid + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13189"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15754"/>
            <dbReference type="ChEBI" id="CHEBI:17615"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.26"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:13190"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>a 1,2-diacyl-3-O-[alpha-D-galactosyl-(1-&gt;6)-beta-D-galactosyl]-sn-glycerol + H2O = acyl-3-O-[alpha-D-galactosyl-(1-&gt;6)-beta-D-galactosyl]-sn-glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48372"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28396"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:90310"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:48373"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="34">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a monoacyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44664"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:84465"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="34">
            <dbReference type="Rhea" id="RHEA:44665"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17855"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:12045"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>di-(9Z)-octadecenoylglycerol + H2O = (9Z-octadecenoyl)-glycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:47868"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:75937"/>
            <dbReference type="ChEBI" id="CHEBI:75945"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:47869"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="36">
            <text>long chain 1,2-diacyl-3-O-[alpha-D-galactosyl-(1-&gt;6)-beta-D-galactosyl]-sn-glycerol + H2O = long chain acyl-3-O-[alpha-D-galactosyl-(1-&gt;6)-beta-D-galactosyl]-sn-glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:90463"/>
            <dbReference type="ChEBI" id="CHEBI:90774"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="36">
            <dbReference type="Rhea" id="RHEA:48709"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="32">
            <text>long chain 1,2-diacyl-3-O-beta-D-galactosyl-sn-glycerol + H2O = long chain acyl-3-O-beta-D-galactosyl-sn-glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:90477"/>
            <dbReference type="ChEBI" id="CHEBI:90770"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="32">
            <dbReference type="Rhea" id="RHEA:48701"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycerolipid metabolism; triacylglycerol degradation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="18">Glycolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Neuron projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 43">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="19">Zymogen granule membrane</location>
            <topology evidence="19">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 42">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.3" evidence="43"/>
    <dbReference type="RefSeq" id="XP_015722907.1">
        <property type="nucleotide sequence ID" value="XM_015867421.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UFN1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005034871.1">
        <property type="protein sequence ID" value="ENSCJPP00005025661.1"/>
        <property type="gene ID" value="ENSCJPG00005020112.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107316185"/>
    <dbReference type="KEGG" id="cjo:107316185"/>
    <dbReference type="GeneTree" id="ENSGT00940000155139"/>
    <dbReference type="OrthoDB" id="199913at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042589">
        <property type="term" value="C:zymogen granule membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047714">
        <property type="term" value="F:galactolipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004465">
        <property type="term" value="F:lipoprotein lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00707">
        <property type="entry name" value="Pancreat_lipase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01759">
        <property type="entry name" value="PLAT_PL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000033">
        <property type="entry name" value="Pancreatic triacylglycerol lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.60.20:FF:000003">
        <property type="entry name" value="Triacylglycerol lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.60.20">
        <property type="entry name" value="PLAT/LH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013818">
        <property type="entry name" value="Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016272">
        <property type="entry name" value="Lipase_LIPH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033906">
        <property type="entry name" value="Lipase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002331">
        <property type="entry name" value="Lipase_panc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001024">
        <property type="entry name" value="PLAT/LH2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036392">
        <property type="entry name" value="PLAT/LH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000734">
        <property type="entry name" value="TAG_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610:SF165">
        <property type="entry name" value="PANCREATIC LIPASE-RELATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00151">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01477">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000865">
        <property type="entry name" value="Lipoprotein_lipase_LIPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00823">
        <property type="entry name" value="PANCLIPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00821">
        <property type="entry name" value="TAGLIPASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00308">
        <property type="entry name" value="LH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49723">
        <property type="entry name" value="Lipase/lipooxygenase domain (PLAT/LH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50095">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 39" id="KW-0106">Calcium</keyword>
    <keyword evidence="15" id="KW-0966">Cell projection</keyword>
    <keyword evidence="16" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="13 40 41" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 43" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="11 43" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 39" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="46" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 43" id="KW-0964">Secreted</keyword>
    <keyword evidence="43" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="43">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034992252" description="Triacylglycerol lipase" evidence="43">
        <location>
            <begin position="18"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="PLAT" evidence="44">
        <location>
            <begin position="352"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="38">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="38">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="38">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <feature type="binding site" evidence="39">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
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        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
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        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="40">
        <location>
            <begin position="21"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="40">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="40">
        <location>
            <begin position="252"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="40">
        <location>
            <begin position="300"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="40">
        <location>
            <begin position="313"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="40 41">
        <location>
            <begin position="448"/>
            <end position="464"/>
        </location>
    </feature>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="46">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
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    </evidence>
    <sequence length="464" mass="50849" checksum="BBC2AED47AB8DDDC" modified="2022-01-19" version="1">MLRIGILALFLLCTARGAEVCYDRLGCFTDDRPWSGTAERPIQRLPWSPERVATQFLLHTRESGGGYQEISAATIGSSNFKTSRKTRFVVHGFIDEGEEGWPSDLCKKILTVDDVNCIAVSWKRGARCAYTQAANNIRVVGAEIAYLINVLKDQYSYSPANVHIIGHSLGAHVAGEAGKRVPGIARITGLDPAQPYFQDTPIEVRLDKSDAEFVDVIHTDTAPFIPNLGFGMSPAIGHLDFYPNGGVEMPGCDKNPLSQIVDLDGIWEGTKDFVACNHLRSYKYYYDSISYPDGFLGYTCGSYDAFKQGCFPCPSGGCPNMGHYADKFKGKTSGSFVKLYLNTASARDFPLWRYKVTLKLAGSSKVSGYLNIALYGSNGNTRQHQIFKGTVHAGNTYTAFIDAEHKVGKVTKVKFLWNNSVVNPSLPKLGAATVEVQVGETGETFKFCGSETVREDVLQTLNAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UHG3</accession>
    <name>A0A8C2UHG3_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma</fullName>
            <ecNumber evidence="20">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="31" type="primary">PLCG1</name>
    </gene>
    <organism evidence="31 32">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="31" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="31" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="31" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="19">Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, EGFR, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration. Guanine nucleotide exchange factor that binds the GTPase DNM1 and catalyzes the dissociation of GDP, allowing a GTP molecule to bind in its place, therefore enhancing DNM1-dependent endocytosis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43484"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58433"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:43485"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:33180"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Lamellipodium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Ruffle</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="20"/>
    <dbReference type="Ensembl" id="ENSCJPT00005036467.1">
        <property type="protein sequence ID" value="ENSCJPP00005026928.1"/>
        <property type="gene ID" value="ENSCJPG00005020909.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158901"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032587">
        <property type="term" value="C:ruffle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005168">
        <property type="term" value="F:neurotrophin TRKA receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071364">
        <property type="term" value="P:cellular response to epidermal growth factor stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007173">
        <property type="term" value="P:epidermal growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046488">
        <property type="term" value="P:phosphatidylinositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="P:positive regulation of angiogenesis"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043536">
        <property type="term" value="P:positive regulation of blood vessel endothelial cell migration"/>
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    <dbReference type="GO" id="GO:2000353">
        <property type="term" value="P:positive regulation of endothelial cell apoptotic process"/>
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        <property type="term" value="P:positive regulation of epithelial cell migration"/>
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        <property type="entry name" value="C2_PLC_like"/>
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    </dbReference>
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        <property type="entry name" value="PH_PLC_gamma"/>
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        <property type="entry name" value="1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma"/>
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        <property type="entry name" value="C2 domain"/>
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    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
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    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
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        <property type="entry name" value="C2_domain_sf"/>
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    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
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    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
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        <property type="entry name" value="PI-PLC_fam"/>
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        <property type="entry name" value="PLC-gamma"/>
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    <dbReference type="InterPro" id="IPR035023">
        <property type="entry name" value="PLC-gamma_C-SH2"/>
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    <dbReference type="InterPro" id="IPR035024">
        <property type="entry name" value="PLC-gamma_N-SH2"/>
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    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057061">
        <property type="entry name" value="PLCG_EF-hand_2"/>
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    <dbReference type="InterPro" id="IPR035724">
        <property type="entry name" value="PLCgamma1_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF173">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23583">
        <property type="entry name" value="EF_HAND_2_PLCG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000952">
        <property type="entry name" value="PLC-gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
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        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="16" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8 20 24" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 20 24" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="14 20 24" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="13 22" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="4 23" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="15 20" id="KW-0807">Transducer</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="PH" evidence="28">
        <location>
            <begin position="18"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="26">
        <location>
            <begin position="541"/>
            <end position="648"/>
        </location>
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    <feature type="domain" description="SH2" evidence="26">
        <location>
            <begin position="659"/>
            <end position="743"/>
        </location>
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    <feature type="domain" description="SH3" evidence="27">
        <location>
            <begin position="778"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="28">
        <location>
            <begin position="877"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="domain" description="PI-PLC Y-box" evidence="30">
        <location>
            <begin position="935"/>
            <end position="1052"/>
        </location>
    </feature>
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        <location>
            <begin position="1053"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="513"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="21">
        <location>
            <position position="1203"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="21">
        <location>
            <position position="1230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004466"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00004510"/>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00053042"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="PIRSR" id="PIRSR000952-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="26">
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            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
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    </evidence>
    <evidence type="ECO:0000259" key="28">
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005026928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1291" mass="148078" checksum="CD0061B0A99DD6B7" modified="2022-01-19" version="1">MAAGSGAPSEAEAAHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQVTWSRGSDKTEGAVDIREIKEIRPGKNSRDFDRYQEDPCFRPDQSHCFVVLYGTEFRLKTLSLQATSEDEVNMWIKGLNWLVADTLRAATPLQIERWELSPVLGLISAKDLKNMLSQVNYRVPNMRFLRERLTDMEQRNGDITYGQFAQLYRSLMFSAQKTVRAQFSRAEKRNFSLCALRGGERSEHFRVSLMEFQKFLLEYQRELWAADSLQVQEFMFNFLRDPLREIDEPYFSLDEFLTFLFSKENSIWNSQLDMVCPENMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMGCRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLVTIKEHAFVTSDFPVILSIEDHCSIAQQRNMAQNFKKVFGDMLLTKPVDISADGLPSPNQLKRKILIKHKKLAEGSAYEELPTSVMYSENDISNSIKNGILYLEDPINHEWNPHYFVLTSSKIYYSGETTSDQGNEDEEEQKEVSNSTELHSTEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFWRNGKVQHCRIHSRQDAGSPKFFLTDNLVFDSLYDLITHYQEVPLRCNEFEMRLTEPVPQTNAHESKEWYHANLTRAQAEHMLMRVPRDGAFLVRKRSEPSSFRAEGKIKHCRVQQEGQTVLLGNSEFESLVDLISYYEKHPLYRKMKLRYPINEETLEKIGTAEPDYGALYEGRHPGFYVEANPMPTFKCAVKALFDYKAQREDELTFTKNAIIQNVEKQEGGWWRGDYGGKKQLWFPSNYVEEISSPSSLEAEREQLDENSPLGDLLGGVLDCLPPPSGKNNRLFVFSISMASVSRLSLDVAADTHEDLLDWVKKIREAAQTADARLSEGKMMERRKKIALELSELVVYCRPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKIKGKKFLQYNRLQLSRIYPKGQRLDSSNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFLSSGQCGYVLQPANMRDDIFDPFDKSTLRGVEPLSISIEVLGARHLPKNGRGIVCPFVEVEVSGAEYDNAKQKTEIVADNGLNPLWSPKQFHFQVSNPEFAFLRFVVYEEDMFSDENFLAQATFLVKGLKTGFRAVPLKNNYSENLELASLLVKIDIFPSKENGDISLFGGSVLRERGGDMASQLLASRAREGSFEVRYQQPFEDFRVSQEQLAEHFESRERRWALGRVLGGQAVKCSILIELSRSLVCFLEALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UI08</accession>
    <name>A0A8C2UI08_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Podocin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">NPHS2</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Plays a role in the regulation of glomerular permeability, acting probably as a linker between the plasma membrane and the cytoskeleton.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2UI08"/>
    <dbReference type="Ensembl" id="ENSCJPT00005037251.1">
        <property type="protein sequence ID" value="ENSCJPP00005027573.1"/>
        <property type="gene ID" value="ENSCJPG00005021365.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234614"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036057">
        <property type="term" value="C:slit diaphragm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072249">
        <property type="term" value="P:metanephric podocyte development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000004">
        <property type="entry name" value="Putative membrane protease family, stomatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043202">
        <property type="entry name" value="Band-7_stomatin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264">
        <property type="entry name" value="BAND 7 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264:SF127">
        <property type="entry name" value="PODOCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Band 7" evidence="8">
        <location>
            <begin position="121"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="349"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="24"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="370"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00053394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00071670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005027573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="381" mass="42632" checksum="F7039F48233E4CD0" modified="2022-01-19" version="1">MDKRSRSSSRESHRRKRQSPATQRKQEKRERSKEASKETGDIRQEKKEIKSAVGTDGRVHTSTVVDVDDVISDEEMEAMMLLDSEHQEEGMKSPGLNICEWLLTILSFLFIIMTFPISVWFCMKVVREYERAIVFRLGHLLPGRARGPGLFFYLPCLDTYHKVDLRLKTLEIPFHQVVTKDMVTLEIDAVCYYRLENASLLLTTLTSISSAIQLLVQTTTKRLLAHRAFSELLLERKSISQEIKVALDAVTGCWGIKVERTEINNVQLPAEVQQSLAVEAEAQRQAKVRVIAAEGEKAASESLRMAAEILSSAPAAAQLRYLHALHSLAAEKPAAFILPLPLDPTNLVSPATRSPPGVSTVITDSTELPESVKDNKDSPML</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UIC6</accession>
    <name>A0A8C2UIC6_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromobox 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">CBX4</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015735615.1">
        <property type="nucleotide sequence ID" value="XM_015880129.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UIC6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005036946.1">
        <property type="protein sequence ID" value="ENSCJPP00005027312.1"/>
        <property type="gene ID" value="ENSCJPG00005021189.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107322261"/>
    <dbReference type="KEGG" id="cjo:107322261"/>
    <dbReference type="CTD" id="8535"/>
    <dbReference type="GeneTree" id="ENSGT00940000160081"/>
    <dbReference type="OrthoDB" id="1918685at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035102">
        <property type="term" value="C:PRC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051219">
        <property type="term" value="F:phosphoprotein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032183">
        <property type="term" value="F:SUMO binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061665">
        <property type="term" value="F:SUMO ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd18645">
        <property type="entry name" value="CD_Cbx4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.40:FF:000006">
        <property type="entry name" value="Chromobox protein homolog 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043531">
        <property type="entry name" value="CBX4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033773">
        <property type="entry name" value="CBX7_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017984">
        <property type="entry name" value="Chromo_dom_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46727">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE CBX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46727:SF1">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE CBX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17218">
        <property type="entry name" value="CBX7_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00504">
        <property type="entry name" value="CHROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Chromo" evidence="7">
        <location>
            <begin position="11"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="94"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="159"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="273"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="455"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="161"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="177"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="215"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="277"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="390"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="463"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="483"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005027312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="523" mass="58408" checksum="51CC4C6CAD1DB08C" modified="2022-01-19" version="1">MELPAVGEHVFAVESIEKKRIRKGRVEYLVKWRGWSPKYNTWEPEENILDPRLLIAFQNRERQEQLMGYRKRGPKPKPLVVQLPSFARRSNILTGLQDPAVDTRPKLDLGSSGKSQQHQYELNSKKHHQYQPNGKESGVKHQSHSKGKYYYQLNSKKHHHYQPDPKMYEPHYHPSSKEPQGQTCLDSTKSPLGAHPDKWAHGATKNLLGPVKNLATESKNGAEKNLSSGTGPPPRDRVTSNGLGGKMKIVKNKNKNGRIVIVMSKYMENGMQAVKIKSGEPPRKRAPEDRTAKKGGEEKLEAWRKPGEERAVGSNGLTAAEGESRQLAAELQESPRKPSPGKELPLPVAEQPLQLTTKPDLVPWSLSSGHEHSPSSMGLNLSSPSARKRCLSEPHGDREPGKKRLTSRSISAPTCLGPERPELPAQPEVILLDSDLDEPIDLRCVKPRVEGEATLVQVKPEEPPVPAEQPPVEPPQQPRQVAEEEEEEEAEGLQEFKPFFGNIIITDVTANCLTVTFKEYVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y762</accession>
    <name>A0A8C2Y762_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein atonal homolog 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ATOH8</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y762"/>
    <dbReference type="Ensembl" id="ENSCJPT00005008195.1">
        <property type="protein sequence ID" value="ENSCJPP00005004973.1"/>
        <property type="gene ID" value="ENSCJPG00005004828.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161151"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140297">
        <property type="term" value="F:DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070888">
        <property type="term" value="F:E-box binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001704">
        <property type="term" value="P:formation of primary germ layer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051450">
        <property type="term" value="P:myoblast proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001937">
        <property type="term" value="P:negative regulation of endothelial cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045603">
        <property type="term" value="P:positive regulation of endothelial cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010595">
        <property type="term" value="P:positive regulation of endothelial cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902895">
        <property type="term" value="P:positive regulation of miRNA transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060391">
        <property type="term" value="P:positive regulation of SMAD protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035148">
        <property type="term" value="P:tube formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd11421">
        <property type="entry name" value="bHLH_TS_ATOH8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000052">
        <property type="entry name" value="Protein atonal homolog 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032660">
        <property type="entry name" value="ATOH8_bHLH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050359">
        <property type="entry name" value="bHLH_transcription_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19290">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19290:SF102">
        <property type="entry name" value="TRANSCRIPTION FACTOR ATOH8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="9">
        <location>
            <begin position="114"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="44"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="68"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00076520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005004973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="259" mass="28195" checksum="8F65AE86B5353DC9" modified="2022-01-19" version="1">MRSTPLAEGEPWPRLCPAAELGGLRRLRRKHGCKSFRVELKVLSGRRPGIRAPPAPPPPPPAPPPAWEPRGAAALGAASSAFPAPPPPPPAASPRPRPGEAAGVSPEIKALQQTRRLLANARERTRVHTISAAFEALRKQVPCYSYGQKLSKLAILRIACNYILSLARLADLDYSADHSNMSFSECVEQCTRTLQAEGRSKKRKVCCSLLHPPNNGKTYKRGGKKINPKPFPSFLNLSNFSCFFTPHLSPTSQLLAFSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y7J9</accession>
    <name>A0A8C2Y7J9_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">5'-3' exonuclease PLD3</fullName>
            <ecNumber evidence="10">3.1.16.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Phospholipase D3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">PLD3</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Exonucleolytic cleavage in the 5'- to 3'-direction to yield nucleoside 3'-phosphates.</text>
            <dbReference type="EC" id="3.1.16.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Early endosome membrane</location>
            <topology evidence="9">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Late endosome membrane</location>
            <topology evidence="8">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Lysosome lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phospholipase D family.</text>
    </comment>
    <dbReference type="EC" id="3.1.16.1" evidence="10"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y7J9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005009866.1">
        <property type="protein sequence ID" value="ENSCJPP00005006238.1"/>
        <property type="gene ID" value="ENSCJPG00005005862.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183059"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043202">
        <property type="term" value="C:lysosomal lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045145">
        <property type="term" value="F:single-stranded DNA 5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014902">
        <property type="term" value="P:myotube differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050874">
        <property type="entry name" value="Diverse_PLD-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032803">
        <property type="entry name" value="PLDc_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10185:SF16">
        <property type="entry name" value="5'-3' EXONUCLEASE PLD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10185">
        <property type="entry name" value="PHOSPHOLIPASE D - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13918">
        <property type="entry name" value="PLDc_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="14">
        <location>
            <begin position="172"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="400"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="413"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="422" mass="45019" checksum="D3253F076B9509CA" modified="2022-01-19" version="1">NPNPIPITPMASPAPHPAPHLPPPPPPKGSPPSLGGQHAVGAALHYIALHCIALHCIPLHCMPCSAVLVVSTPSGLHHSSFPSTFSCWLHLLRSARRSVDVASFYWTMSNNDTNTTEQTAAPVNSGVLWGQWEQWGGLWGTLCCVMGGPIADLWGLCPTGAAVRMVDVGRLAGGVLHTKLWVVDGAHVYLGSANMDWRSLTQVKELGVALYNCSIAAQDVAKVFEAYWALGAPNASIPRPWPGNFSTSFNMETPLRLRLNGTPTALYFSSSPPSFCAAGRTPDLQAVLGVINSARSFIDVAVMSYLPASEFQRHNRFWPPIDDALRRAVFERGVRLKLLLGCWAHSKAAMFPFIKSLAAISDNRTGYSAQVVSVSCQIVSHRGNKGGLVAQGEHWGVGNGVTGGSGSDMSVSRADHGEGGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y956</accession>
    <name>A0A8C2Y956_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Vav guanine nucleotide exchange factor 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">VAV2</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y956"/>
    <dbReference type="Ensembl" id="ENSCJPT00005013750.1">
        <property type="protein sequence ID" value="ENSCJPP00005009181.1"/>
        <property type="gene ID" value="ENSCJPG00005007190.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159718"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005154">
        <property type="term" value="F:epidermal growth factor receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001784">
        <property type="term" value="F:phosphotyrosine residue binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030032">
        <property type="term" value="P:lamellipodium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051897">
        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd20868">
        <property type="entry name" value="C1_VAV2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21263">
        <property type="entry name" value="CH_VAV2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01223">
        <property type="entry name" value="PH_Vav"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10406">
        <property type="entry name" value="SH2_Vav2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11980">
        <property type="entry name" value="SH3_VAV2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11977">
        <property type="entry name" value="SH3_VAV2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.900.10:FF:000009">
        <property type="entry name" value="Vav guanine nucleotide exchange factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000015">
        <property type="entry name" value="Vav guanine nucleotide exchange factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000019">
        <property type="entry name" value="Vav guanine nucleotide exchange factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000050">
        <property type="entry name" value="Vav guanine nucleotide exchange factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000024">
        <property type="entry name" value="Vav guanine nucleotide exchange factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000039">
        <property type="entry name" value="Vav guanine nucleotide exchange factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022613">
        <property type="entry name" value="CH_CAMSAP_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037832">
        <property type="entry name" value="PH_Vav"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055251">
        <property type="entry name" value="SOS1_NGEF_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035880">
        <property type="entry name" value="VAV2_SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035733">
        <property type="entry name" value="VAV2_SH3_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035732">
        <property type="entry name" value="VAV2_SH3_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45818:SF4">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR VAV2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45818">
        <property type="entry name" value="PROTEIN VAV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11971">
        <property type="entry name" value="CAMSAP_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22697">
        <property type="entry name" value="SOS1_NGEF_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 9" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="1 10" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="15">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="14">
        <location>
            <begin position="193"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="13">
        <location>
            <begin position="400"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="16">
        <location>
            <begin position="516"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="12">
        <location>
            <begin position="578"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="11">
        <location>
            <begin position="665"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="12">
        <location>
            <begin position="808"/>
            <end position="869"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005009181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="870" mass="100946" checksum="E101E41E5DE17DED" modified="2022-01-19" version="1">MEEWRQCGRWLIDCKVLPPNHRVVWPSAVVFDLAQALRDGVLLCQLLHNLSPGSIDLKDINFRPQMSQFLCLKNIRTFLKVCHDKFGLRNSDLFDPFDLFDVRDFGKVISAVSRLSFHTIAQTKGIRPFPSEETTENDDDVYRSLEELADEHDLGEDIYDCVPCEDEGDDIYEDIIRVEVQQPMKMGMTEDDKRNCCLLEIQETEAKYYKTLEDIEKNYMNPLKLVLTPQDMEAIFINLEDLIKVHFNFLRAIDVSMMSGGSSLAKVFLEFKERLLIYGKYCSHMEYAQNTLNHLIANRDDVRQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSSDRPEKQQLKEALEAMQDLAMYINEVKRDKETLKKISEFQSSIENLQVKLEEFGRPKIDGELKVRSIVNHTKQDRYLFLFDKVVIVCKRKGYNYELKEIIELLFHKMTDDPMNNKDIKKVGGWSYGFYLIHLQGKQGFQFFCKTEEMKRKWMEQFEMAMSNIKPEKANANHHSFQMYTFEKTTNCKACKMFLRGTFYQGYLCPKCGAGAHKECLEIIPPCKMGDRDETALHLPPGPKMVAVQNYHGNPAPPGKPVLTFQIGDVIELLRGDPESPWWRGRLLQTKKSGYFPSSSVKPCPVDARPPNSRPPSREIDYTVYPWFAGNMERQQTDNLLKAHVSGTYLIRERPAEAERFAISIKFNEEVKHIKVVEKDNWIHITEAKKFESLLELVEYYQNHSLKESFKQLDTTLKYPYKSRERSTSRTFTRSPASCASYNFSFLSPQGLNFSSQSSSSPFWSVFTPRVIGTAVARYNFAARDMRELSLREGDVVKIYSRIGGDQGWWKGETNGRVGWFPSTYVEEEGVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y9E1</accession>
    <name>A0A8C2Y9E1_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Taxilin beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">TXLNB</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the taxilin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015713898.1">
        <property type="nucleotide sequence ID" value="XM_015858412.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015713899.1">
        <property type="nucleotide sequence ID" value="XM_015858413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y9E1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005014982.1">
        <property type="protein sequence ID" value="ENSCJPP00005010068.1"/>
        <property type="gene ID" value="ENSCJPG00005008811.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107311675"/>
    <dbReference type="KEGG" id="cjo:107311675"/>
    <dbReference type="CTD" id="167838"/>
    <dbReference type="GeneTree" id="ENSGT00940000157418"/>
    <dbReference type="OrthoDB" id="425555at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026183">
        <property type="entry name" value="Taxilin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16127:SF10">
        <property type="entry name" value="BETA-TAXILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16127">
        <property type="entry name" value="TAXILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09728">
        <property type="entry name" value="Taxilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="71"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="464"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="618"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="160"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="305"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="379"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="75"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="625"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005010068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="676" mass="77036" checksum="EE166243851DB83A" modified="2022-01-19" version="1">MENDQFTEKQQQVSTSPRQDIQGQSKEEPVPSSQPLPPTDQTSAQTEAATCDISEELSRQLEDIIKTYGSAASLMEKDGTTAGTDKLEKGDVGNMEDAEYEDANEESEKDKPAPGDASRAKEPSTSKEQKLEKKILKGLGKEATLLMQTLNKLTTPEEKLDLLFKKYAELLEEHRAEQKQLKYLQKRQAQITKEKDQLQSEHSRAILARSKLESLCRELQRHNKTLKEETIQRAREEDEKRKEITNHFQGTLSEIQAQIEQQSERNMKLCQENTELAEKLKSIIDQYELREEHLDKIFKHRELQQKLVDAKLEQSQEMMKEAEERHQKEKEYLLNQAAEWKLQAKMLKEQETVLQAQITLYSERFEEFQKTLTKSNEVFATFKQEMEKMTKKMKKLEKDTATWKSRFENCNRALLDMIEEKAMRTKEYECFVLKIQRLENLCRALQEERNELYRKIKQAQLPEEVNGNDILEDDDDTNTNPSSPEQASIELYAADKNMLQELAEAFRVTHKAEETLPSDSSSSETCDVQMCKASSAPELPSHLTSQPEAGNHCEQFSMSTSAPPEHMPASTENMTTPIENMPKATKSMPMPPEMVPTPTESVPIPTEGVPTHPKIMPATPESVPTPMQNTSAPVGNMPPSTKSTPEAVEHVGDIAELFVQDQPAEQKGDTDMEAVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y9U2</accession>
    <name>A0A8C2Y9U2_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Calcium homeostasis modulator family member 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">CALHM5</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CALHM family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015714110.1">
        <property type="nucleotide sequence ID" value="XM_015858624.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y9U2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005015672.1">
        <property type="protein sequence ID" value="ENSCJPP00005010621.1"/>
        <property type="gene ID" value="ENSCJPG00005009213.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107311807"/>
    <dbReference type="KEGG" id="cjo:107311807"/>
    <dbReference type="CTD" id="254228"/>
    <dbReference type="GeneTree" id="ENSGT01030000234610"/>
    <dbReference type="OrthoDB" id="5953668at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005261">
        <property type="term" value="F:monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904669">
        <property type="term" value="P:ATP export"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029569">
        <property type="entry name" value="CALHM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32261">
        <property type="entry name" value="CALCIUM HOMEOSTASIS MODULATOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32261:SF8">
        <property type="entry name" value="CALCIUM HOMEOSTASIS MODULATOR PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14798">
        <property type="entry name" value="Ca_hom_mod"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005010621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="309" mass="35582" checksum="0CF00C9BD8F82393" modified="2022-01-19" version="1">MDGFRTILKFFMNRRTAIGYSVMALLTLGSERAFSLVAFRCPCSNENFKYGLAFLFSPALLLFVFGYFLNNKTWKLFTGCWVNPRKIFPKGNICHFFIIFGQITLNALVAPVMWLSVALLNGTFYECAMSGLRNPAYLDAICHNKSVKCFEELYKVSCDKSTMPFSESEELKLTLQAHSQILGWCVIVAMAVFSLLTTCCASCQSKVSHLQLKFWKVYAEKEKEQLEQTFQLYATKLSERNLKCFFENSKPEVMPLPAFQAWEDASQLHTFSSSKQHYSTIHRLVEEGQKEVSEERETTYDFVDRREIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YAJ0</accession>
    <name>A0A8C2YAJ0_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YAJ0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005017995.1">
        <property type="protein sequence ID" value="ENSCJPP00005012421.1"/>
        <property type="gene ID" value="ENSCJPG00005010563.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000167890"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034209128" evidence="1">
        <location>
            <begin position="17"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005012421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="58" mass="6663" checksum="667FDF08E2EBBC5A" modified="2022-01-19" version="1">MELLNAFLFAFFQVFQLLTDLKQQRKESGKSKQSSGQQNLNTIMYEVGDTVNHPCKIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YB22</accession>
    <name>A0A8C2YB22_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">CCR4-NOT transcription complex subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">CCR4-associated factor 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">CNOT1</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the CNOT1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015729064.1">
        <property type="nucleotide sequence ID" value="XM_015873578.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005019057.1">
        <property type="protein sequence ID" value="ENSCJPP00005013228.1"/>
        <property type="gene ID" value="ENSCJPG00005007823.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107319059"/>
    <dbReference type="CTD" id="23019"/>
    <dbReference type="GeneTree" id="ENSGT00390000014869"/>
    <dbReference type="OrthoDB" id="1933107at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070016">
        <property type="term" value="F:armadillo repeat domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030331">
        <property type="term" value="F:nuclear estrogen receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042974">
        <property type="term" value="F:nuclear retinoic acid receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035195">
        <property type="term" value="P:miRNA-mediated post-transcriptional gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033147">
        <property type="term" value="P:negative regulation of intracellular estrogen receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048387">
        <property type="term" value="P:negative regulation of retinoic acid receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010606">
        <property type="term" value="P:positive regulation of cytoplasmic mRNA processing body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900153">
        <property type="term" value="P:positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060213">
        <property type="term" value="P:positive regulation of nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000036">
        <property type="term" value="P:regulation of stem cell population maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd20710">
        <property type="entry name" value="NOT1_connector"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.800:FF:000001">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000005">
        <property type="entry name" value="Ccr4-not transcription complex subunit 1 isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.790:FF:000001">
        <property type="entry name" value="Ccr4-not transcription complex subunit 1 isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.840:FF:000001">
        <property type="entry name" value="Ccr4-not transcription complex subunit 1 isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.840">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 1 TTP binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007196">
        <property type="entry name" value="CCR4-Not_Not1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055454">
        <property type="entry name" value="CNOT1-like_NOT1_connector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055104">
        <property type="entry name" value="CNOT1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032191">
        <property type="entry name" value="CNOT1_CAF1_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024557">
        <property type="entry name" value="CNOT1_dom_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032194">
        <property type="entry name" value="CNOT1_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032193">
        <property type="entry name" value="CNOT1_TTP_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038535">
        <property type="entry name" value="CNOT1_TTP_bind_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040398">
        <property type="entry name" value="Not1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162:SF8">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22940">
        <property type="entry name" value="CNOT1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16415">
        <property type="entry name" value="CNOT1_CAF1_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16418">
        <property type="entry name" value="CNOT1_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16417">
        <property type="entry name" value="CNOT1_TTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12842">
        <property type="entry name" value="DUF3819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04054">
        <property type="entry name" value="Not1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23590">
        <property type="entry name" value="NOT1_connector"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 N-terminal" evidence="19">
        <location>
            <begin position="30"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 HEAT repeat" evidence="18">
        <location>
            <begin position="500"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 TTP binding" evidence="17">
        <location>
            <begin position="816"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 CAF1-binding" evidence="16">
        <location>
            <begin position="1088"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1" evidence="15">
        <location>
            <begin position="1387"/>
            <end position="1534"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1-like NOT1 connector" evidence="20">
        <location>
            <begin position="1610"/>
            <end position="1814"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-Not complex component Not1 C-terminal" evidence="14">
        <location>
            <begin position="2005"/>
            <end position="2364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="724"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1315"/>
            <end position="1352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1315"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1330"/>
            <end position="1351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00071432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF12842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF16415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF16417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF16418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF22940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF23590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005013228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="2383" mass="267715" checksum="6085FDE14DBCC3E3" modified="2022-01-19" version="1">MNLDSLSLALSQISYLVDNLTKKNYRASQQEIQHIVNRHGPEADRHLLRCLFSHVDFSGDGKSSGKDFHQTQFLIQECASLITKPNFISTLSYAIDNPLHYQKSLKPSPHLFAQLSKVIKLSKVQEVIFGLALLNSFSSDLRGFAAQFIKQKLPDLLRSYIDADVSGNQEGGFQDIAIEVLHLLLSHLLFGQKGAFGVGQEQIDAFLKTLRRDFPQERCPVVLAPLLYPEKRDILMDRILPDSGGIAKTMMESSLADFMQEVGYGFCTSVEECRNIIMQFGVREVTAAQVARVLGMMARTHSGLTDGIPLQSISAPGSGIWSDGKDKSDGAQAHTWNVEVLIDVLKELNPSLDFKVVTYELDHPGFQIRDSKGLHIVVFGIQRGLGMEVFPVNAIYRPWKHAEGQLSFIQHSLINPDIFCFADYPCHTVTTDILKAPPEDDNREIATWKSLDLIESLLRLAEVGQYEQVKQLFSFPIKHCPDMLVLALLQINTSWHTLRHELISTLMPIFLGNHPNSAIILHYAWHGQGQSPSIRQLIMHAMAEWYMRGEQYDQAKLSRILDVAQDLKALSMLLNGTPFAFVIDLAALASRREYLKLDKWLTDKIREHGEPFIQACMTFLKRRCPSILGGLAPEKDQPKSAQLPPETLATMLACLQACAGSVSQELSETILTMVANCSNVMNKARQPPPGVMPKGRPPSASSLDAISPVQIDSLAGMASLSLGGSAAPHTQSMQGFPPNLGSAFSTPQSPAKAFPPLSTQNQTTGFSGIGGLSSQLPVGGLTTGSLTGIGTGALGLPAVNNDPFVQRKLSTSGLSQPTFQQSKMKPSDLSQVWPEANQNFSKEIDDEANSYFQRIYNHPPHPTMSVDEVLEMLQRFKDSNIKREREVFNCMLRNLFEEYRFFPQYPDKELHITACLFGGIIEKGLVTYMALGLALRYVLEALRKPFASKMYYFGIAALDRFKNRLKDYPQYCQHLASISHFIQFPHHLQEYIEYGQQSRDPPVKMQGSITTPGSIALAQAQAQAQVPAKAPLAGQVSTIVTTSTTTTVAKTITITRPTGVSFKKDVPPSINTTNIDTLLVATDQTERIVEPPENVQEKIAFIFNNLSQSNMTQKVEELKETVKEEFMPWVSQYLVMKRVSIEPNFHSLYSNFLDTLKNPEFNKMVLNETYRNIKVLLTSDKAAANFSDRSLLKNLGHWLGMITLAKNKPILHTDLDVKSLLLEAYVKGQQELLYVVPFVAKVLESSVRSVVFRPPNPWTMAIMNVLAELHQEHDLKLNLKFEIEVLCKNLALDINELKPGSLLKDKDRLKNLDEQLSAPKKDVKQPEELPPITTTTASTTPATSTTCTATVPPQPQYSYHDINVYSLGGLAPHITLNPTIPLFQAHPQLKQCVRQAIERAVQELVHPVVDRSIKIAMTTCEQIVRKDFALDSEESRMRVAAHHMMRNLTAGMAMITCREPLLMSIATNLKNSFATALRAASPQQRDMMEQAAAQLAQDNCELACCFIQKTAVEKAGPEMDKRLATEFELRKHARQEGRRYCDPVVLTYQAERMPEQIRLKVGGVDLKQLAVYEEFARNVPGFLPTNDLTQPTGFLAQPMKQAWATDDVAQIYDKCMTELEQHLQSIPHTLAMNPQAQALRSLLEAVVVARNSRDAIAALGLLQKAVEGLLDATSGADADLLLRYRECHLLVLKALQDGRAYGSPWCNKQITRCLIECRDEYKYNVEAVELLIRNHLVNMQQYDLHLAQSMENGLNYMAVAFAMQLVKILLVDERSVAHVTEADLFHTIETLMRINAHSRGNAPEGLPQLMEVVRSNYEAMIDRAHGGPNFMMHSGISQASEYDDPPGLREKAEYLLREWVNLYHSAAAGRDSTKAFSAFVGQVELLERKMHQQGILKTDDLITRFFRLCTEMCVEISYRAQAEQQHNPAANPTMIRAKCYHNLDAFVRLIALLVKHSGEATNTVTKINLLNKVLGIVVGVLLQDHEVRQGEFQQLPYHRIFIMLLLELNAPEHVLETINFQTLTAFCNTFHILRPTKAPGFVYAWLELISHRIFIARMLAHTPQQKGWPMYAQLLIDLFKYLAPFLRNVELTKPMQILYKGTLRVLLVLLHDFPEFLCDYHYGFCDVIPPNCIQLRNLILSAFPRNMRLPDPFTPNLKVDMLSEINIAPRILTNFTGVMPPQFKKDLDSYLKTRSPVTFLSDLRSNLQVSNEPGNRYNIQLINALVLYVGTQAIAHIHNKGSTPSMSTITHSAHMDIFQNLAVDLDTEGRYLFLNAIANQLRYPNSHTHYFSCTMLYLFAEANTEAIQEQITRVLLERLIVNRPHPWGLLITFIELIKNPAFKFWNHEFVHCAPEIEKLFQSVAQCCMGQKQAQQVMEGTGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YBL5</accession>
    <name>A0A8C2YBL5_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Sp4 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">SP4</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the Sp1 C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015709316.1">
        <property type="nucleotide sequence ID" value="XM_015853830.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YBL5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005020487.1">
        <property type="protein sequence ID" value="ENSCJPP00005014384.1"/>
        <property type="gene ID" value="ENSCJPG00005012018.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107309213"/>
    <dbReference type="KEGG" id="cjo:107309213"/>
    <dbReference type="CTD" id="6671"/>
    <dbReference type="GeneTree" id="ENSGT00940000157827"/>
    <dbReference type="OrthoDB" id="6365676at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd22536">
        <property type="entry name" value="SP4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000014">
        <property type="entry name" value="Transcription factor Sp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000026">
        <property type="entry name" value="Transcription factor Sp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000061">
        <property type="entry name" value="Transcription factor Sp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039938">
        <property type="entry name" value="Sp4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14947:SF23">
        <property type="entry name" value="SP4 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14947">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="643"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="673"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="703"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="104"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="280"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="104"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="116"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="299"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="339"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="369"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005014384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="780" mass="81299" checksum="0D9169A294A4DF49" modified="2022-01-19" version="1">MSDQKKEETMPTEGEKSPEAENNNNNNKKGKTGGSQDSQPSPLALLAATCSKIGTPGENQATGQQQIIIDPNQGLVQLQNQPQQLELVTTQLAGNSWQLVAASPSASKDNNVAQQGSSTASSAPSPSSSNNGSSSPTKTKSGNSSATTPGQFQVIQVQNPSGSVQYQVIPQIQTTEGQQIQINPANATGLQDIQGQIQLIPAGNNQAILTASNRTASGNIIAQNLANQTVPVQIRPGVSIPLQLQTIPGAQAQVVTTLPINIGGVTLALPVINNMAAGGGSGQVGQSTEGGVSNGSQLASTPVTSASVSSMPDSPSSSSTSTTTASTSLTSSDTLVSSAETGQYTSTAGGSSEQPTEESQTTATDSEAQSSSQLQSNGLQNVQDQSGSLQQVQIVGQPILQQIQIQQPQQQIIQAIPPQSFQLQSGQTIQTIQQQSLQNVQLQAVSPTQVLIRAPTLTPSGQISWQTVQVQNLQSLSNLQVQNAGLPQQLTITPVSSSGGTTIAQIAPVAVAGTPITLNAAQLASVPNLQTVSVANLGAAGVQVQGVPVTITSVAGQQQGQDGVKVQQATIAPVTVAVGGIANAGIGAVSPDQITQVQLQQAQQASDQEAQPGKRTRRVACSCPNCREGEGRSSNEPGKKKQHICHIEGCGKVYGKTSHLRAHLRWHTGERPFICNWVFCGKRFTRSDELQRHRRTHTGEKRFECPECSKRFMRSDHLSKHVKTHQNKKGGGTALAIVTSGELDSSVTEVLGSPRIVTVAAISQDSNPATPNVSTNMEEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YBT7</accession>
    <name>A0A8C2YBT7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Diphthamide biosynthesis protein 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">CSL-type zinc finger-containing protein 2</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2 [3Fe-4S](0)-[protein] + 2 Fe(2+)-[Dph3] + NADH = 2 [4Fe-4S](1+)-[protein] + 2 [Dph3] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:71239"/>
            <dbReference type="Rhea" id="RHEA-COMP:17997"/>
            <dbReference type="Rhea" id="RHEA-COMP:17998"/>
            <dbReference type="Rhea" id="RHEA-COMP:18001"/>
            <dbReference type="Rhea" id="RHEA-COMP:18002"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:33723"/>
            <dbReference type="ChEBI" id="CHEBI:47402"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[3Fe-4S](1+)-[protein] + Fe(2+)-[Dph3] = [3Fe-4S](0)-[protein] + Fe(3+)-[Dph3]</text>
            <dbReference type="Rhea" id="RHEA:71235"/>
            <dbReference type="Rhea" id="RHEA-COMP:17996"/>
            <dbReference type="Rhea" id="RHEA-COMP:17997"/>
            <dbReference type="Rhea" id="RHEA-COMP:18002"/>
            <dbReference type="Rhea" id="RHEA-COMP:18003"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:33751"/>
            <dbReference type="ChEBI" id="CHEBI:47402"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase. Interacts with SERGEF.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DPH3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2YBT7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005021482.1">
        <property type="protein sequence ID" value="ENSCJPP00005015127.1"/>
        <property type="gene ID" value="ENSCJPG00005012569.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000172652"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.660.10:FF:000001">
        <property type="entry name" value="Diphthamide biosynthesis 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.660.10">
        <property type="entry name" value="DPH Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044248">
        <property type="entry name" value="DPH3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007872">
        <property type="entry name" value="DPH_MB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036671">
        <property type="entry name" value="DPH_MB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21454:SF31">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21454">
        <property type="entry name" value="DPH3 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05207">
        <property type="entry name" value="Zn_ribbon_CSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144217">
        <property type="entry name" value="CSL zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51074">
        <property type="entry name" value="DPH_MB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DPH-type MB" evidence="10">
        <location>
            <begin position="4"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="76" mass="8430" checksum="FF0914808F2C0536" modified="2022-01-19" version="1">MAVFHDEVEIEDFEYDEETETYSYPCPCGDRFLITREDLENGEDVATCPSCSLILRVIYDQVSGVGTGGASKVLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YCQ1</accession>
    <name>A0A8C2YCQ1_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cytochrome b5 domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC107324333</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2YCQ1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005023770.1">
        <property type="protein sequence ID" value="ENSCJPP00005016989.1"/>
        <property type="gene ID" value="ENSCJPG00005013916.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00440000037582"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052320">
        <property type="entry name" value="Cytochrome_b5_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21281">
        <property type="entry name" value="CYTOCHROME B5 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21281:SF0">
        <property type="entry name" value="CYTOCHROME B5 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="206"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="356"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005016989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="420" mass="46147" checksum="42898056935D974B" modified="2022-01-19" version="1">MEAPGPAPHTPHPISHTPHPTPLPSRPVPVRFRRSPSPGPSAAPSFPARCPRSFWTRIVSRRAPRSSRPLGSVRFGSVQLSSVRFGSARFSPAPLGPAVQPPAARRWTTAPVMPRGASPPTSGLRRRFPCRRHFGVLVAMDTAGGAERRPRYLTVREVAEEPGRLSALGRVYDLGPLLRERRGDAALNPLLGALGTDVSHCFDTDTGHPLSRVEPRTGQSGSRFPLGVPGSSQLHTPRSDGAPPWDAEWWRDPRLQLGRLSAAPRLLRLLNTLTGHSCVIEVCGEEPVGAALQRARGWREQLRKYTVCYGGVPLQPHLTLEQNGIPDGTAELRSLRLDPKDFIPTVLLYFNDDVGEDSEGRSSKCPQNPEDRPPFPPRMHPPKIAPQHLIYLRTPKTLKTRTPRSPPSNFHPTLAFPALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YDD1</accession>
    <name>A0A8C2YDD1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA mismatch repair protein MLH1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">DNA mismatch repair protein Mlh1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">MutL protein homolog 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">MLH1</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2YDD1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005025267.1">
        <property type="protein sequence ID" value="ENSCJPP00005018154.1"/>
        <property type="gene ID" value="ENSCJPG00005014774.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00800000124177"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005712">
        <property type="term" value="C:chiasma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005715">
        <property type="term" value="C:late recombination nodule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001673">
        <property type="term" value="C:male germ cell nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000795">
        <property type="term" value="C:synaptonemal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032137">
        <property type="term" value="F:guanine/thymine mispair binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032407">
        <property type="term" value="F:MutSalpha complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016321">
        <property type="term" value="P:female meiosis chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007129">
        <property type="term" value="P:homologous chromosome pairing at meiosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008630">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to DNA damage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045190">
        <property type="term" value="P:isotype switching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007060">
        <property type="term" value="P:male meiosis chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043060">
        <property type="term" value="P:meiotic metaphase I homologous chromosome alignment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051257">
        <property type="term" value="P:meiotic spindle midzone assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045141">
        <property type="term" value="P:meiotic telomere clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045950">
        <property type="term" value="P:negative regulation of mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048477">
        <property type="term" value="P:oogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048298">
        <property type="term" value="P:positive regulation of isotype switching to IgA isotypes"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048304">
        <property type="term" value="P:positive regulation of isotype switching to IgG isotypes"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009617">
        <property type="term" value="P:response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016446">
        <property type="term" value="P:somatic hypermutation of immunoglobulin genes"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd16926">
        <property type="entry name" value="HATPase_MutL-MLH-PMS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03483">
        <property type="entry name" value="MutL_Trans_MLH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000014">
        <property type="entry name" value="DNA mismatch repair protein Mlh1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000034">
        <property type="entry name" value="DNA mismatch repair protein mlh1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032189">
        <property type="entry name" value="Mlh1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="MutL/Mlh/PMS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF12">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16413">
        <property type="entry name" value="Mlh1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="17">
        <location>
            <begin position="351"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="534"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="589"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="534"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="600"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00071080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00072852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00082865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005018154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="892" mass="99660" checksum="2FB7942CF6874CCC" modified="2022-01-19" version="1">MVEISSVLLSTIINIPDLTVTKLLLSFYTPTSLIQFLRNKYLQIFTSPHAAPQWPRPSHGVAQWPLEAPPPSLLSANHRAAPPCHRLSTPSLYLPRAGRRPSDGHSFCPIAELRVRGAGQCCCLERYSIAGRAFTMALVAGVIRRLDEAVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVVVKEGGLKLIQVQDNGCGIRKEDLHIVCERFTTSKLQKFEDLASISTYGFRGEALASISHVAHVTVTTKTADAKCAYRASYSDGKIKAPPKPCAGNQGTQIMVEDLFYNVNTRRKALKNPSEEYAKILEVVGRYAIHNSGISFSVKKQGDTVSDVRTLSNATTVDNIRSIFGNAVSRELIEVGCEDANLAFKMKGYITNANYSVKKCIFLLFINHRLVESTALRKAIETVYAAYLPKSTHPFLYLSLEIAPKNVDVNVHPTKHEVHFLHEDSILERVQQHIESKLLGSNSSRMYYTQTLLPGAECSSSEVVKSAASSSTATKGTSDKVYAHQMVRTDSREQKLDAFLQPVNNSQSTGPTEETSGVNVGPPEGTVRPQDAEMEDVSELLETADVIEMADVQQDAVMPGGLSKSGHLSPEKAVPRKRPREDTDVRMEEDTGKEMTAACTPKRRIINLTSVLTLQDEISNQAHESLQEMLRDHSFVGCVSPQWALVQHRTKLYLLNTTKLSQELFYQILIYDFANFGVLRLSEPAPLYELAMLALEDPESGWTEEDGPKEGLAEYIVEFLKKKTEMLKDYFSLEIDEEGNLIGLPLLIDNYIPLLEGLPMFILRLATEVNWDEEKECFESLSKELSLFYSIRKQYIMDETNLTHSQNEDSDSSSPPWKWTVEHVVYKAFRTHLLPPKHFTDDGNILQLANLPDLYKVFERC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YDR4</accession>
    <name>A0A8C2YDR4_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Brain abundant membrane attached signal protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BASP1</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BASP1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2YDR4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005026489.1">
        <property type="protein sequence ID" value="ENSCJPP00005019114.1"/>
        <property type="gene ID" value="ENSCJPG00005015520.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00730000111450"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030054">
        <property type="term" value="C:cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016605">
        <property type="term" value="C:PML body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072112">
        <property type="term" value="P:podocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097435">
        <property type="term" value="P:supramolecular fiber organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008408">
        <property type="entry name" value="BASP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23212">
        <property type="entry name" value="BRAIN ACID SOLUBLE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23212:SF0">
        <property type="entry name" value="BRAIN ACID SOLUBLE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05466">
        <property type="entry name" value="BASP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="36"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="130"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="146"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="211"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005019114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="220" mass="22706" checksum="67F5E639911F2C78" modified="2022-01-19" version="1">MGGKLSKKKKGYSVNDEKAKDKDKKAEGAATEEEEKVEKDSQVAANKTEEKEGEKEKTVTQEEAQKAEPEKSEAVVDAKVEPQKNNEQAPKQEEPAAASAPAASSEAPKTSEPSSDAKASQPSEATAPSKADDKSKEDGEAKKTEAPATPAAQETKSEVAPASDSKPSSSEAAPSSKETVAATAAPSSTAKASEPSAPPEEAKPSEAPATNSDQTIAVQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YDX1</accession>
    <name>A0A8C2YDX1_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tripartite motif-containing protein 7-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC107321540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015734026.1">
        <property type="nucleotide sequence ID" value="XM_015878540.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YDX1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005026916.1">
        <property type="protein sequence ID" value="ENSCJPP00005019438.1"/>
        <property type="gene ID" value="ENSCJPG00005015745.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107321540"/>
    <dbReference type="KEGG" id="cjo:107321540"/>
    <dbReference type="GeneTree" id="ENSGT01030000234669"/>
    <dbReference type="OrthoDB" id="9395240at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="CDD" id="cd12888">
        <property type="entry name" value="SPRY_PRY_TRIM7_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000004">
        <property type="entry name" value="Butyrophilin subfamily 1 member A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003879">
        <property type="entry name" value="Butyrophylin_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006574">
        <property type="entry name" value="PRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050143">
        <property type="entry name" value="TRIM/RBCC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24103">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13765">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01407">
        <property type="entry name" value="BUTYPHLNCDUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00589">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="2">
        <location>
            <begin position="266"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005019438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="455" mass="51453" checksum="714C5E75343056C0" modified="2022-01-19" version="1">MASAVPGAKEKGDEGSHHPIPEHQMGNGCSSSVGHGGGISHRNHLRKGNFHTKLHLEHLAEKLKLLGLDGDKGEKEKICSWRKRTFLSNGPRDDGDPNGAPIKESVQEDGEQICSYLENLKKHKEELLELKMNGERRCQDFMTRTEAERQKIVSGFRQIRCFLKEKEVMLLAQLGELDRAVLRRQEEEEAKVEGDISLLSILICEMEEKLKRPTHGFLQDARRTLDRWEMGRTQRMMENFIDVERRLHIISQQHQILCEALGRFQDLLSSELEREEGTSEEEGKAFVTLDPTTATAGLVLSRDRRGVRWMDIGHNVSPCPQRFDVSCCVLGCQGFTSGQHFWDVEVISGGTWALGVARSSVPRKGWLTFHPDYGIWAMGCCRNGYRAFTSPPSTLPVSGNPNRIRVVLDYGGGRVIFYLAAQKDPIYAFQNASFYGESIFPFFWVGRGSHLRLCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YEH9</accession>
    <name>A0A8C2YEH9_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta/gamma crystallin 'Greek key' domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta/gamma-crystallin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2YEH9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005028504.1">
        <property type="protein sequence ID" value="ENSCJPP00005020663.1"/>
        <property type="gene ID" value="ENSCJPG00005016611.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00420000030545"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005212">
        <property type="term" value="F:structural constituent of eye lens"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002088">
        <property type="term" value="P:lens development in camera-type eye"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.20.10">
        <property type="entry name" value="Crystallins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050252">
        <property type="entry name" value="Beta/Gamma-Crystallin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001064">
        <property type="entry name" value="Beta/gamma_crystallin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011024">
        <property type="entry name" value="G_crystallin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11818">
        <property type="entry name" value="BETA/GAMMA CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11818:SF103">
        <property type="entry name" value="BETA_GAMMA CRYSTALLIN 'GREEK KEY' DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00030">
        <property type="entry name" value="Crystall"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00247">
        <property type="entry name" value="XTALbg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49695">
        <property type="entry name" value="gamma-Crystallin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50915">
        <property type="entry name" value="CRYSTALLIN_BETA_GAMMA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Beta/gamma crystallin 'Greek key'" evidence="3">
        <location>
            <begin position="2"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="Beta/gamma crystallin 'Greek key'" evidence="3">
        <location>
            <begin position="43"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005020663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="185" mass="21211" checksum="C2F125D5B7911C33" modified="2022-01-19" version="1">MNKITVYERADFEGLSREFTCDVPDLHELDFGDCIASLKVVGQPWIAYTQPKYEGEPHVFEEGEYEAVERPNSFSALRLVHHDLLDPQITLYERPHLQGACKVVSEETNLAYGYFNDRVASHVVQRGVWLLYQHPNRGGWHCLAWPGERVDDYGAQLNFQARLSHLRPLRPVSEYSDPLEGAIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YFD2</accession>
    <name>A0A8C2YFD2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Autophagy-related protein 101</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATG101 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2YFD2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005030711.1">
        <property type="protein sequence ID" value="ENSCJPP00005022417.1"/>
        <property type="gene ID" value="ENSCJPG00005017859.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome LGE22C19W28_E50C23"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012445">
        <property type="entry name" value="ATG101"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13292">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13292:SF0">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07855">
        <property type="entry name" value="ATG101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005022417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="130" mass="14026" checksum="56236945E491D938" modified="2022-01-19" version="1">MLAVLHTVLLHRSTGKFHYKKEGTYSIGTVGTQDVDCDFIDFAYVRVSSEELDRALRKAVGDTLPPPGAHWDTLVAKAAQIIVVLVLCVAVAFGVLFLGCNLLLQAESMAAPPARDHRPPHGDEGMTEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YFU7</accession>
    <name>A0A8C2YFU7_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytosolic 5'-nucleotidase 1A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC107314558</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YFU7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005032072.1">
        <property type="protein sequence ID" value="ENSCJPP00005023403.1"/>
        <property type="gene ID" value="ENSCJPG00005018571.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000017767"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046085">
        <property type="term" value="P:adenosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010394">
        <property type="entry name" value="5-nucleotidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31367">
        <property type="entry name" value="CYTOSOLIC 5'-NUCLEOTIDASE 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31367:SF3">
        <property type="entry name" value="CYTOSOLIC 5'-NUCLEOTIDASE 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06189">
        <property type="entry name" value="5-nucleotidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005023403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="361" mass="40112" checksum="2AF7644B2D8B36F4" modified="2022-01-19" version="1">MQPGMQPAHSADYKSHHARGRAVPSTQLPASCWLQRDISNSTWVKWGRGVDAALDEETALVKDPSEALVIAVTTRAIFNLEEEHQLYLEKGKEEYVRHQQANQDKPLPPGTAFAFIQAAQYVNKKILESNPMEKGLFDILVLSNNSPESGMRIINSVKHYGLEISKFCFVSDEDSTQYLKSHGVKLFLSADRTDVCNALRRGVSAALIFQQEVQATSTPLRVAFDGDAVLFSDETDQIFREQGLEGAMQYERAMEAVPIGEGPMKAFAMHLGKIRKKFSQEESPIRTYLVTARSGRDMGIRAIKTLREWGLAIDEAFFMDGAPKGPILAQIQPHIFFDDGLHNIQGAQDVGVPSAWVPSCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SMY0</accession>
    <name>A0A8C2SMY0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP-dependent RNA helicase DHX29</fullName>
            <ecNumber evidence="11">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">DEAH box protein 29</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 15" type="primary">DHX29</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Part of the 43S pre-initiation complex (PIC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="11"/>
    <dbReference type="RefSeq" id="XP_015704195.1">
        <property type="nucleotide sequence ID" value="XM_015848709.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005001996.1">
        <property type="protein sequence ID" value="ENSCJPP00005001162.1"/>
        <property type="gene ID" value="ENSCJPG00005001224.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107305983"/>
    <dbReference type="KEGG" id="cjo:107305983"/>
    <dbReference type="CTD" id="54505"/>
    <dbReference type="GeneTree" id="ENSGT00940000157286"/>
    <dbReference type="OrthoDB" id="5600252at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome Z"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:ribonucleoside triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043024">
        <property type="term" value="F:ribosomal small subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008494">
        <property type="term" value="F:translation activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045948">
        <property type="term" value="P:positive regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042255">
        <property type="term" value="P:ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000325">
        <property type="entry name" value="ATP-dependent RNA helicase DHX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000500">
        <property type="entry name" value="ATP-dependent RNA helicase DHX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000002">
        <property type="entry name" value="Putative ATP-dependent RNA helicase DHX36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03068">
        <property type="entry name" value="DHX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034730">
        <property type="entry name" value="DHX29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056328">
        <property type="entry name" value="DSRM_DHX29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059023">
        <property type="entry name" value="RNA_hel_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056890">
        <property type="entry name" value="UBA_DHX29-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF264">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24385">
        <property type="entry name" value="DSRM_DHX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26026">
        <property type="entry name" value="RNA_hel_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24899">
        <property type="entry name" value="UBA_DHX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 11" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="581"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="847"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="180"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="321"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="11"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="347"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005001162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1369" mass="154576" checksum="7AE18430A8BB725D" modified="2022-01-19" version="1">MGGRNKKHRGGSSAHAVSAATAATAAARSRAAAEAGSAAANEATGSRAAPRPPPACKEPRVKQGPKTYSFSSPIDSNAAAAANQDKSILKVMISSNLEKRIIDLINDHKKQNNDKGMISKRLTAKKLQDVYMALQRFSFKTEHIEEAMKNTLLYGGDLHSALDWLCLNLPDDALPEGFSQQFEEQQHKPRAKFCSPVSQREPPPRLTVKKKKENSPETKETNMKEQKEMSMKEWILRYAEQQSDEEKNESVKEADEEKFDPNERYVHLAAKLSEAKEQASTSKQDKDKQGQKVAQEKIRRIQQEMAMLEEHPVFDPAIKTSNQQQKEKKKVPPPQPQETTLNLSLLEKPDGAAKEEKAKKKEPLDIRNFDYSARSWTGKSPKQFLIDWCRKNFPKSPNPAFEKVPVGRYWKCRVRVTKSSDDVMTMCPTIVTEDSMQAQHLAATLALYHLTKGQSVHQLLPPTYRDVWLEWSDIEKKKEEENKIETNKPRDNFIAKLLNKLKQQQQLQSEKQPKVSEGPEDSWENLVSDEDFSSLSLETVNTDNLEPSRNLFRKLRSSSRYQEFLKERQELPVFKHRHSIVETLKKHRVVVVAGETGSGKSTQVPHFLLEDLLLDERTSKCNIVCTQPRRISAVSLATRVCEELGCESGPGGKNSLCGYQIRMESRTGEATRLLYCTTGVLLRKLQEDGLLSSVSHVIVDEVHERSVQSDFLLVILKEILHKRSDLHLILMSATVDSEKFSSYFSHCPILRISGRSYPVEVFHVEDVIEATGYVLEKDSEYCQKFLEEEEEVVINVTTKGGGTAKYQEYVPVQSGSGIDLAPYYQKYSSRTQQAVFYMNPYKINLELILELLAYLDTSPQFRNIEGAVLVFLPGLAHIQQLYDLISTDRRFSLCDRHRLIALHSVLSTQDQASAFTIPPLGIRKIVLATNIAETGITIPDVVFVIDSGRTKENRYHESSQMSSLEETFVSKASALQRQGRAGRVRDGFCFRMYTRDRFESFMEYSVPEILRVPLEELCLHIMKCNLGSPEDFLSRALDPPQPQVIGNAMNLLRKIGACQLNEPKLTPLGQHLAALPVNVKIGKMLIFGAIFGCLDPVATLAAVMTEKSPFTTPIGRKDEADLAKSSIALAVSDHITIYNAYLGWKKARQEGGHRAEMTYCRRNFLNRTSLLTLEDVKQELIRVVRAAGFTAPTTQHRWDGNGATQSLSLHEIALLKAVLTAGLYDNVGKIIYTKSVDITEKLACLVETAQGKAQVHPSSVNRDLQVYGWLLYQEKVRYAKVYLRETTLISPFPILLFGGDIEVQHRERLLTVDGWIHFQAPVKIAVIFKQLRVLIESVLQKKLENPKMSLEDDKVLQVIKELIKTENGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SP50</accession>
    <name>A0A8C2SP50_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Zinc finger protein 662-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC107307790</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SP50"/>
    <dbReference type="Ensembl" id="ENSCJPT00005002816.1">
        <property type="protein sequence ID" value="ENSCJPP00005001665.1"/>
        <property type="gene ID" value="ENSCJPG00005001714.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163453"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000128">
        <property type="entry name" value="zinc finger protein 268 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000087">
        <property type="entry name" value="Zinc finger protein 354B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001437">
        <property type="entry name" value="Zinc finger protein 594"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002533">
        <property type="entry name" value="Zinc finger protein 770"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050758">
        <property type="entry name" value="Znf_C2H2-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23234:SF8">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23234">
        <property type="entry name" value="ZNF44 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KRAB" evidence="14">
        <location>
            <begin position="88"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="327"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="355"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="383"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="411"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="439"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="467"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="495"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="209"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005001665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="523" mass="59381" checksum="1E1BE7FE4767307B" modified="2022-01-19" version="1">MGCYRDLWRFLPSPISVQWLIRTHRNPELPVPIYIRFPSGLFRPLPLLSPVLVPKVWTRKAVLCLPTMIISPAGEQQMATAHPAEEPVSFAEVAVYFNREEWELLDPEQRALYRDVMLDTYQCVASLAPFPAPKPVLISRLEGGGDPWIPAGDPWIPDGCGHGDGPGGLSPEGLRVIKVELQEDDAQWGGIISTGEIRRADGIDGIEHPELLGGHRGEPRGDLVEPRGDPLETNVGPKEPRNRIEPNVGPKEPRNQIEPNVGLKEPRNQIEPNVGPKEPRNVIEPNVGQNQIEPNVGPKEPQNQIEPNVGPKDPEEQRKKPKKLKQHQCTECGKGFVRFSNLLIHQRLHSGKCSLKCPECGKSYKWRSELNKHQRVHTGERPYKCSQCDKTFMSRTGLRYHQRIHNSERDFHCSQCGKSFQSSSNLFRHQRMHTEDRPYGCNECDKSFKIRSNLIRHQRIHTGERPYKCSQCGKCFKSSSDLVVHQRIHTGERPYKCSQCGKSYKSNGDLKYHQRSHTGEEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SPD7</accession>
    <name>A0A8C2SPD7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aquaporin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC107317915</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015726603.1">
        <property type="nucleotide sequence ID" value="XM_015871117.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SPD7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005002170.1">
        <property type="protein sequence ID" value="ENSCJPP00005001274.1"/>
        <property type="gene ID" value="ENSCJPG00005001313.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107317915"/>
    <dbReference type="KEGG" id="cjo:107317915"/>
    <dbReference type="GeneTree" id="ENSGT00530000063816"/>
    <dbReference type="OrthoDB" id="1580043at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1080.10:FF:000018">
        <property type="entry name" value="Aquaporin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051883">
        <property type="entry name" value="AQP11/12_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016697">
        <property type="entry name" value="Aquaporin_11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023265">
        <property type="entry name" value="Aquaporin_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21191">
        <property type="entry name" value="AQUAPORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21191:SF8">
        <property type="entry name" value="AQUAPORIN-12A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017529">
        <property type="entry name" value="Aquaporin_11/12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02025">
        <property type="entry name" value="AQUAPORIN12"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="33"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="274"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="277"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR017529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005001274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="299" mass="32440" checksum="D0B9D8B3F733C2FF" modified="2022-01-19" version="1">MSGLNISIGFFFLVLGTCEVLRRLSKRLLAPGLLGCLAAELAGSLLLCSGCLELRMLLEIGPWGGLGPDVVLTLFFLLFMVHTACANGAAANPTISLQEFLLFECGPVATVAKLLVQCVGAGMGWALTKLYWSWELTQLHLIQKLMASECSSSIRTSPHLGALVEAACSFFFHLVLLRVRRSPAVCRLPVLATTVTFLTYVATPATGAFFNPALATASTFLCTGSSLQEYIQVYWLGPLAGMLAALLLYQGNIPRFFQRNLLYGQRSKYRIPKARVTHAEDGEQRQKGKGEKSNPAPHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SPK0</accession>
    <name>A0A8C2SPK0_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SPK0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005003297.1">
        <property type="protein sequence ID" value="ENSCJPP00005001889.1"/>
        <property type="gene ID" value="ENSCJPG00005001972.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005001889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="89" mass="9076" checksum="EE0AA839F24EFE2D" modified="2022-01-19" version="1">MVVRAGGNKGPGLPGGGNEEGAAKGATFHTPSLGDEEFEIPPISLDSDPSLAVADFDELGDPPGPPQEPPFAPPYGVQPLDIPWESGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SQJ1</accession>
    <name>A0A8C2SQJ1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Acyl-CoA synthetase short-chain family member 3, mitochondrial</fullName>
            <ecNumber evidence="4">6.2.1.1</ecNumber>
            <ecNumber evidence="3">6.2.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Acetate--CoA ligase 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Propionate--CoA ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ACSS3</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23176"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:23177"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>butanoate + ATP + CoA = butanoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:46172"/>
            <dbReference type="ChEBI" id="CHEBI:17968"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57371"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:46173"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>propanoate + ATP + CoA = propanoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20373"/>
            <dbReference type="ChEBI" id="CHEBI:17272"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.17"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:20374"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.1" evidence="4"/>
    <dbReference type="EC" id="6.2.1.17" evidence="3"/>
    <dbReference type="RefSeq" id="XP_015712896.1">
        <property type="nucleotide sequence ID" value="XM_015857410.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SQJ1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005001856.1">
        <property type="protein sequence ID" value="ENSCJPP00005001076.1"/>
        <property type="gene ID" value="ENSCJPG00005001150.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107311123"/>
    <dbReference type="KEGG" id="cjo:107311123"/>
    <dbReference type="CTD" id="79611"/>
    <dbReference type="GeneTree" id="ENSGT00940000157479"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050218">
        <property type="term" value="F:propionate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05967">
        <property type="entry name" value="PrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000011">
        <property type="entry name" value="Acetyl-coenzyme A synthetase 2-like, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000017">
        <property type="entry name" value="Acyl-CoA synthetase short-chain family member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43347">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43347:SF3">
        <property type="entry name" value="ACYL-COA SYNTHETASE SHORT-CHAIN FAMILY MEMBER 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-coenzyme A synthetase N-terminal" evidence="13">
        <location>
            <begin position="44"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="11">
        <location>
            <begin position="105"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="12">
        <location>
            <begin position="553"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005001076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="668" mass="73529" checksum="35FD90DAD33A3B50" modified="2022-01-19" version="1">MGLLGRMAVLAVRGGAARRWLGRPCAGGRPPARAAASSPALGRYGEVFRSSVEEPEKVWGAAAELIQWSKPWDRALERRGPGSESWFVGGELNICYNAVDRHVENGRGDHTAIIYDSPVTNTKEKITYKELLEQVSKLADVMVRHGVKKGDRVVIYMPMIPQTVCCMLACARIGAIHSLIFGGFASKELSVRIDHAKPRLIVTASFGVEPKRKVEYISLLEGALGMVQHKPEKVLIYRRPNLGHVPLTPGRDLDWEEELAKAQCYKCVSVPSDHPLYILYTSGTTGLPKGVIRPTGGYAVMLNWTMSAIYGLKPGEVWWAASDLGWVVGHSYICYGPLLHGNPTVLYEGKPVGTPDAGAYFRVLAEHEVAAFFTSPTAIRAIRQQDPEAALGKQYSLKRFRMMFVAGEHCDVDTLEWSKKVFKVPVLDHWWQTESGSPITASCVGLGNSTTPPPGQAGKPVPGYNVMILDENKEPVKAKTLGNVVVKLPLPPGAFSGLWENQEAFHKLYFQKFPGYYDTMDAGYMDEDGYLYVLSRADDVINVAGHRISAGAIEECVLRHHAVADCAVVGQEDALKGHVPFALCVLRHDIKTEEKKILEDIVERVRNNIGPVAAFQKGVFVKQLPKTRSGKIPRSALSALVSGKPYKITPTIEDASVFKHIEEVLKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SQP9</accession>
    <name>A0A8C2SQP9_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Very low-density lipoprotein receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">VLDLR</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="14">Homooligomer. Binds to the extracellular matrix protein Reelin/RELN. Interacts with LRP8. Interacts with LDLRAP1. Interacts with SNX17. Interacts with DAB1. Interacts with PCSK9. Interacts with PAFAH1B3 and PAFAH1B2, the catalytic complex of (PAF-AH (I)) heterotetrameric enzyme; these interactions may modulate the Reelin pathway. Interacts with STX5; this interaction mediates VLDLR translocation from the endoplasmic reticulum to the plasma membrane. Interacts with CLU.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <location evidence="1">Clathrin-coated pit</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SQP9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005004264.1">
        <property type="protein sequence ID" value="ENSCJPP00005002372.1"/>
        <property type="gene ID" value="ENSCJPG00005002212.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155460"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome Z"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034361">
        <property type="term" value="C:very-low-density lipoprotein particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034185">
        <property type="term" value="F:apolipoprotein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048306">
        <property type="term" value="F:calcium-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042562">
        <property type="term" value="F:hormone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038025">
        <property type="term" value="F:reelin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034189">
        <property type="term" value="F:very-low-density lipoprotein particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030229">
        <property type="term" value="F:very-low-density lipoprotein particle receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048813">
        <property type="term" value="P:dendrite morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034436">
        <property type="term" value="P:glycoprotein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900006">
        <property type="term" value="P:positive regulation of dendrite development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051963">
        <property type="term" value="P:regulation of synapse assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021517">
        <property type="term" value="P:ventral spinal cord development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034447">
        <property type="term" value="P:very-low-density lipoprotein particle clearance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000009">
        <property type="entry name" value="Low-density lipoprotein receptor isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000052">
        <property type="entry name" value="low-density lipoprotein receptor isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000002">
        <property type="entry name" value="low-density lipoprotein receptor isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000038">
        <property type="entry name" value="Very low density lipoprotein receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000043">
        <property type="entry name" value="Very low density lipoprotein receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000046">
        <property type="entry name" value="Very low density lipoprotein receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000049">
        <property type="entry name" value="Very low density lipoprotein receptor"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Very low density lipoprotein receptor"/>
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        <property type="entry name" value="Very low density lipoprotein receptor"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
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    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
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    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
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    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
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        <property type="entry name" value="EGF_Ca-bd_CS"/>
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    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
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    <dbReference type="InterPro" id="IPR051221">
        <property type="entry name" value="LDLR-related"/>
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    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
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    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
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    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
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        <property type="entry name" value="NOTCH1_EGF-like"/>
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    <dbReference type="PANTHER" id="PTHR22722:SF15">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED"/>
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        <property type="entry name" value="FXa_inhibition"/>
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    </dbReference>
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        <property type="entry name" value="Ldl_recept_a"/>
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    </dbReference>
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        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
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        <property type="entry name" value="EGF"/>
        <property type="match status" value="5"/>
    </dbReference>
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        <property type="entry name" value="LDLa"/>
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        <property type="match status" value="5"/>
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    </dbReference>
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        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="8"/>
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        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="8"/>
    </dbReference>
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        <property type="entry name" value="LDLRB"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 15" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="13" id="KW-0850">VLDL</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="816"/>
            <end position="837"/>
        </location>
    </feature>
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        <location>
            <begin position="376"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="20">
        <location>
            <begin position="416"/>
            <end position="451"/>
        </location>
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        <location>
            <begin position="501"/>
            <end position="546"/>
        </location>
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    <feature type="repeat" description="LDL-receptor class B" evidence="17">
        <location>
            <begin position="547"/>
            <end position="589"/>
        </location>
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    <feature type="repeat" description="LDL-receptor class B" evidence="17">
        <location>
            <begin position="590"/>
            <end position="633"/>
        </location>
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    <feature type="repeat" description="LDL-receptor class B" evidence="17">
        <location>
            <begin position="634"/>
            <end position="676"/>
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    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="9"/>
            <end position="20"/>
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    <sequence length="891" mass="97419" checksum="44478B442790FE14" modified="2022-01-19" version="1">MPGGEGRSARWAAGSAASGRPAVSEGLSNYSATLALWHPAALAWLVSGAKTKCEESQFACSNGRCIPLLWKCDGDEDCSDGSDESACVKKTCAESDFVCNSGQCVPNRWQCDGDPDCEDGSDESAELCHMRTCRVNEISCGPQSTQCIPVSWKCDGEKDCDSGEDEENCGNVTCSAAEFTCTSGQCISKSFVCNGQDDCSDGSDELECAPPTCGVHEFQCKSSTCISASWVCDDDADCPDHSDESLEQCGRQPLPPVKCSTSEVQCGSGECIHKKWRCDGDPDCKDGSDEINCPSRTCRPDQFRCEDGNCIHGTRQCNGVRDCLDGTDEANCNSVIQCSGPGKFKCRSGECIDVNKVCNHQGDCSDWSDEPLKECNINECLVNNGGCSHICRDLVIGYECDCPAGFELVDKRTCGDIDECQNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAVGKEPCLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDADIAEQKLYWADFSQKAIFSASIDTRDKVGTHTRILDNIHSPAGIAVDWIYKNIYWTDSSAKTISVASLNGKKRKVLFLSDLREPASIAVDPLSGFMYWSDWGEPAKIEKAGMNGFDRQQLVTTEIQWPNGIALDLVKSRLYWLDSKLHMLSSVDLNGQDRRLVLKSHMFLPHPLALTIFEDRVFWIDGENEAVYGANKFTGAELVTLVNNLNDAQDIIVYHELVQPSGRNWCEENMVNGGCSYLCLPAPQINEHSPKYTCACPAGYFLQEDGLRCTGTTVTYTEAKDTSTTEKSPTVGLVPGGFNISSVMSEVAATGASGAWAVLPVLLLVMAAVAGYFIWRNWQHKNMKSMNFDNPVYLKTTEEDLTIDIGRHSGSVGHTYPAISVVSTDDDML</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SSN0</accession>
    <name>A0A8C2SSN0_COTJA</name>
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        <submittedName>
            <fullName evidence="5">BTB domain containing 3</fullName>
        </submittedName>
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        <name evidence="5" type="primary">BTBD3</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SSN0"/>
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        <property type="gene ID" value="ENSCJPG00005001943.1"/>
    </dbReference>
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        <property type="component" value="Chromosome 3"/>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021987">
        <property type="term" value="P:cerebral cortex development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:dendrite morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="BACK_BTBD3"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="BTB_POZ_BTBD3"/>
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        <property type="entry name" value="BTB/POZ domain-containing protein 3"/>
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    </dbReference>
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        <property type="entry name" value="BTB/POZ domain-containing protein 3"/>
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        <property type="entry name" value="PHR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BACK"/>
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        <property type="entry name" value="BTB/POZ_dom"/>
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        <property type="entry name" value="PHR"/>
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    <dbReference type="InterPro" id="IPR038648">
        <property type="entry name" value="PHR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF2">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="147"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005001869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="549" mass="61216" checksum="CA0FF058C138CF16" modified="2022-01-19" version="1">MRRNDRSGRKGWGERARRARACGAGALSKRDRAGRCEGPRRPGSGAASETVKNRSKKSSKKGNSNSSSSKLPPVCYEIITLKTKKKKKMAADIFPRKKPANTNTTAVQQYHQQNLNNNNTIPAPNWQGLYPTIRERNAVMFNNDLMADVHFVVGPPGGTQRLPGHKYVLAVGSSVFHAMFYGELAEDKDEIRIPDVEPAAFLAMLKYIYCDEIDLAADTVLATLYAAKKYIVPHLARACVNFLETSLSAKNACVLLSQSCLFEEPDLTQRCWEVIDAQAELALKSEGFCDIDFQTLESILRRETLNAKEIVVFEAALNWAEVECQRQELTATIENKRKVLGKALYLIRIPTMALDDFANGAAQSGILTLNETNDIFLWYTAAKKPELQFVSKPRKGLVPQRCHRFQSCAYRSNQWRYRGRCDSIQFAVDKRVFIAGFGLYGSSCGSAEYSAKIELKRQGVILGQNLSKYFSDGSSNTFPVWFEYPVQIEPDTFYTASVILDGNELSYFGQEGMTEVQCGKVTVQFQCSSDSTNGTGVQGGQIPELIFYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SSN9</accession>
    <name>A0A8C2SSN9_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">LIM homeobox transcription factor 1-alpha-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC107307023</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SSN9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005003288.1">
        <property type="protein sequence ID" value="ENSCJPP00005001881.1"/>
        <property type="gene ID" value="ENSCJPG00005001963.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000165858"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09378">
        <property type="entry name" value="LIM2_Lmx1a_Lmx1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000095">
        <property type="entry name" value="LIM homeobox transcription factor 1 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000040">
        <property type="entry name" value="LIM homeobox transcription factor 1 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050453">
        <property type="entry name" value="LIM_Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208:SF118">
        <property type="entry name" value="LIM HOMEOBOX TRANSCRIPTION FACTOR 1-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208">
        <property type="entry name" value="LIM/HOMEOBOX PROTEIN LHX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6 10 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 10 12" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 11" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="14">
        <location>
            <begin position="75"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="15">
        <location>
            <begin position="171"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="10">
        <location>
            <begin position="173"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="138"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="231"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="235"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005001881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="361" mass="40994" checksum="4EF9DB19B8F34BF0" modified="2022-01-19" version="1">MVLWSVRTHSTQPHPIRSLRTQPTQSHPIVLIIDGVSLQEVCLYVTAPPAQSVSPILPFPQCFTPRFLLYRLFQTKCSSCLKAIAPTELIMRVLENVYHVHCFYCCECERRLQRGDEFVLKEGQLLCKSDYEKEKEMLSAISPAPTESVKSEDEDGGHSQGKGNEDSKDHKRSKRPRTILTTQQRRAFKASFEVSSKPCRKVRETLAAETGLTVRVVQVWFQNQRAKMKKIARRQQQQQQQQQQEQEQMGNPRLGSGRGTGRSSSVHGLDGLMVPYPRLPQQQLLPLDQNGYSTDLYRQGLTPPQLPGDHLHPYVFHDMDSDSISHLGDCLLSTAEANLLQARVGNPIDRLYSMQSSYFTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2ST68</accession>
    <name>A0A8C2ST68_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mitogen-activated protein kinase kinase kinase 7</fullName>
            <ecNumber evidence="5">2.7.11.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="30" type="primary">MAP3K7</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="30" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="30" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="30" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.25" evidence="5"/>
    <dbReference type="RefSeq" id="XP_015714410.1">
        <property type="nucleotide sequence ID" value="XM_015858924.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2ST68"/>
    <dbReference type="Ensembl" id="ENSCJPT00005003763.1">
        <property type="protein sequence ID" value="ENSCJPP00005002097.1"/>
        <property type="gene ID" value="ENSCJPG00005002267.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107311964"/>
    <dbReference type="CTD" id="6885"/>
    <dbReference type="GeneTree" id="ENSGT00940000157785"/>
    <dbReference type="OrthoDB" id="10261027at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140672">
        <property type="term" value="C:ATAC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990450">
        <property type="term" value="F:linear polyubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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</entry>
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            <taxon>Coturnix</taxon>
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                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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        <scope>IDENTIFICATION</scope>
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        <scope>IDENTIFICATION</scope>
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    </dbReference>
    <dbReference type="Pfam" id="PF00880">
        <property type="entry name" value="Nebulin"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00227">
        <property type="entry name" value="NEBU"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51216">
        <property type="entry name" value="NEBULIN"/>
        <property type="match status" value="14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005004028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="597" mass="68606" checksum="B9F88EDB76A72297" modified="2022-01-19" version="1">MELARKCSEIISDVHYKEEFEKSKGKCIFVPDTPQIKHVKSVGALISEVKYKGAAKKDLSNSLYQQMPATIDSVFAKELTQLQSKVLYKQKHDAEKGTSDYAHMKEPPDIKHAMEVNKYQSDVSYKRDVQDTHRYTEVLNRPDIKMATEITKIISDAEYKKGRGEMNKEPAVLGRPDFEHAKGVSKLLSQVKYKEQFKKEMRSHQYNPLDSASFKQAQIASTLASDVNYKKDYKESLHDPASDLPNLLYLNHALNISKMHSDVKYRENYEKSKGKSMLEFVDTPMYQVSKDVQKMQSEKMYRKDFEESLKGRPSLDLDKTPEFLHIKQVTSLLKEKEYRKDLEEWMKGKGMTVFEDTPDLIRVKNAAQILNEKQYKKDLETEIKGKGMQVGPDTPEIRRAKKASEIASTKEYKKDLENEIKGKGMEVGMDTPDIQRAKKASEIVSQKEYRKDLETEIIGKGMQVGPFTPEIQRVKRASEIASQKMYKDEAEKMLCNYSAVPDTPEMERIKSTQKNISSVFYKKVVGAGTAVKETPEMERVKKNQQNISSIKYKEEIQHATPISDLPELRRIKENQKNISNVCPVFIVCSLCCVLEPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SWV5</accession>
    <name>A0A8C2SWV5_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">BTB domain and CNC homolog 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">BACH1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family. CNC subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015736575.1">
        <property type="nucleotide sequence ID" value="XM_015881089.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015736585.1">
        <property type="nucleotide sequence ID" value="XM_015881099.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015736593.1">
        <property type="nucleotide sequence ID" value="XM_015881107.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SWV5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005008244.1">
        <property type="protein sequence ID" value="ENSCJPP00005005017.1"/>
        <property type="gene ID" value="ENSCJPG00005004860.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107322739"/>
    <dbReference type="KEGG" id="cjo:107322739"/>
    <dbReference type="CTD" id="571"/>
    <dbReference type="GeneTree" id="ENSGT00940000158923"/>
    <dbReference type="OrthoDB" id="6365358at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098531">
        <property type="term" value="F:ligand-modulated transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd14719">
        <property type="entry name" value="bZIP_BACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.880.10:FF:000002">
        <property type="entry name" value="transcription regulator protein BACH2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000033">
        <property type="entry name" value="transcription regulator protein BACH2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.880.10">
        <property type="entry name" value="Transcription factor, Skn-1-like, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043321">
        <property type="entry name" value="bZIP_BACH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004826">
        <property type="entry name" value="bZIP_Maf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008917">
        <property type="entry name" value="TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050457">
        <property type="entry name" value="ZnFinger_BTB_dom_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46105">
        <property type="entry name" value="AGAP004733-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46105:SF1">
        <property type="entry name" value="TRANSCRIPTION REGULATOR PROTEIN BACH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03131">
        <property type="entry name" value="bZIP_Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47454">
        <property type="entry name" value="A DNA-binding domain in eukaryotic transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="BTB" evidence="13">
        <location>
            <begin position="36"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="BZIP" evidence="14">
        <location>
            <begin position="580"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="196"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="593"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="295"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005005017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="763" mass="85345" checksum="406AE47B59DDC6BF" modified="2022-01-19" version="1">MSLSEKNSVVFAYESSVHSTNVLLSLDDQRKQDILCDVTVLVEDQRFRAHKAVLAACSSYFLSRIVGQLDADLIITLPEEVTLKGFSPLLQFAYTAKLILNKDNVSEVCKCAEFLGVRNIEESCFQFLKFKFLDCKSDQEWPRKKCCTQHCRKVNPKISNVDDGDLEIDDEAEELLEKEYIQASHAKLCKDDDSAKASPALQDNANPTSDPMHLEKGNVSSSSSQCPKYRKFQKAFGNDKVHTSDSSSSTKDVQVPPIVTFIEKEIPDNDSPTKAQECVPMQLVSKCEETQVKMEEGEEDIEKKEESKRDSVTQGISCPVEKMDVAAFPQNTAAPHGLNSVSFLRTCEQYGNFSSMQSTTTLSEKTATGTGAESDKFESHDNATLKVDLCTREAINVTSTGDRSSVEREVAEHLAKGFWSDIYSTERCQIHLPSAVPKERLEPTYSAKKSECPWLGIRISESPEPCPPRTFTTLSSVNCPFISNLSTEGCSNSSEISSGDYVQGQQQEQCPYNYVISLGEDSETDTEGDSESCSAREQECEVKLPFNAQRIISLSRNDFQSFLKMHKLTPEQLDCIHDIRRRSKNRIAAQRCRKRKLDCIQNLESEIEKLQNEKENLLKERNLILSTLGETKQNLTGLCQQVCKEAALSNEQIQILAKYSSSDCPLYFSFPERERSAPSEGEVTTPTATELVDDLSSVTPTDEQISCYQRVKSVCDATYDQVQELHPVPVRTLEKTSLVEQCGQSGAITDFCQQMTDKCTTDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SXP2</accession>
    <name>A0A8C2SXP2_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Protein inhibitor of activated STAT 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">PIAS2</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIAS family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SXP2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005008732.1">
        <property type="protein sequence ID" value="ENSCJPP00005005364.1"/>
        <property type="gene ID" value="ENSCJPG00005004954.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234539"/>
    <dbReference type="UniPathway" id="UPA00886"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome Z"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016605">
        <property type="term" value="C:PML body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061629">
        <property type="term" value="F:RNA polymerase II-specific DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061665">
        <property type="term" value="F:SUMO ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060766">
        <property type="term" value="P:negative regulation of androgen receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.720.30:FF:000001">
        <property type="entry name" value="E3 SUMO-protein ligase PIAS2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="E3 SUMO-protein ligase PIAS2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.780">
        <property type="entry name" value="PINIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023321">
        <property type="entry name" value="PINIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038654">
        <property type="entry name" value="PINIT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782:SF12">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE PIAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782">
        <property type="entry name" value="ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14324">
        <property type="entry name" value="PINIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51466">
        <property type="entry name" value="PINIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51044">
        <property type="entry name" value="ZF_SP_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SAP" evidence="12">
        <location>
            <begin position="11"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="PINIT" evidence="14">
        <location>
            <begin position="134"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="SP-RING-type" evidence="13">
        <location>
            <begin position="331"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="572"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="584"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005005364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="611" mass="67109" checksum="CC3DD4779C65EE19" modified="2022-01-19" version="1">MADFEELRNMVSSFRVSELQVLLGFAGRNKSGRKHDLLMRALHLLKSGCSPAVQIKIRELYRRRYPRTIEGLSDLSAIKPAVFNLDSSSSPVEPDLAVAGIHPIPSTSVTPQSPSSPVSSVLLQDTKAHFEMQQPSPPIPPVHPDVQLKSLPFYDVLDVLIKPTSLVQSSIQRFQEKFFIFALTPQQVREICISRDFLPGGRRDYTVQVQLRLCLAETSCPQEDNYPNSLCIKVNGKLFPLPGYAPPPKNGIEQKRPGRPLNITSLVRLSSAVPNQISISWASEIGKSYSMSVYLVRQLTSAMLLQRLKMKGIRNPDHSRALIKEKLTADPDSEIATTSLRVSLMCPVSKAGNCHCFDAALYLQMNEKKPTWICPVCDKKAAYESLILDGLFMEILNECSDVDEIKFQEDGSWCPMRPKKDAVKVSSPQCTKIESSSVVSKPCSVTVASEENKKKVDVIDLTIESSSDEEEDPPAKRKCIFMSETQGSPTKGVLMYQPSSVRVPSVTTVDTAAIPPSLSDYPVPFHHPPMSSISSDLPGLDFLSLIPVESQYCPPMFLDSLTSTLTSNTPGSIITSTSHHESSTHVSSSNRSESGVITSSSGSAPDIISLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SXT4</accession>
    <name>A0A8C2SXT4_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">PH domain leucine-rich repeat-containing protein phosphatase 2</fullName>
            <ecNumber evidence="5">3.1.3.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">PH domain leucine-rich repeat-containing protein phosphatase-like</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">PHLPP2</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser-657' of PRKCA. Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis. Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation. Inhibits cancer cell proliferation and may act as a tumor suppressor. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Dephosphorylates RAF1 inhibiting its kinase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 24">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005006841.1">
        <property type="protein sequence ID" value="ENSCJPP00005003981.1"/>
        <property type="gene ID" value="ENSCJPG00005003992.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159841"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045171">
        <property type="term" value="C:intercellular bridge"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd13322">
        <property type="entry name" value="PH_PHLPP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17241">
        <property type="entry name" value="RA_PHLPP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000027">
        <property type="entry name" value="PH domain and leucine rich repeat protein phosphatase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000120">
        <property type="entry name" value="PH domain and leucine rich repeat protein phosphatase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000003">
        <property type="entry name" value="PH domain and leucine-rich repeat protein phosphatase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055071">
        <property type="entry name" value="RA_PHLPP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF43">
        <property type="entry name" value="PH DOMAIN AND LEUCINE RICH REPEAT PROTEIN PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23010">
        <property type="entry name" value="RA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="21">
        <location>
            <begin position="802"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1070"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1141"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1297"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="1141"/>
            <end position="1156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00058248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00072392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00078933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005003981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1333" mass="146796" checksum="B261733F0E0FEEE5" modified="2022-01-19" version="1">EVGGGPGRAGPFRAESPRRPFPAARRAGRPRALNVKRNGSRSCLNRSRFSSRERDWLREDVGRGCVYVYGGDSAASSDLRLVLCTVDTPAAEICDGEERKNLFVQLHGDLVRRLEPTEKPLQIVYDYLAGLGFDDPVRVQEEAANSDLSCMIRFYSEKPCQMEQLDRILLSGIYNVRKGKTQLHKWAERLVILCGTCLIVSSVKDSHTGKMHILPLVGGKVEEMKRRQYTLAFTSAGAQAQTYHVSFETLAECQRWHRQASTVVSMRLSMVDLSCYSLEEVPEHLFYSQDITYLNLRHNFMRSSRAGSLDSLCRFSQLKSLNLSHNRLGEFPVSLCEISTLTELNMSCNGLHHLPSQISKLLNLQSFWLDGNFLTSLPEELGSLQQLSCLGLSFNNFCELPAICEKLTVLDKIAMAGNLLENLDLKVLNRMSHIKSVDLRLNNLKRAAADTLEGNKSVTYMDLRDNQLTDLDLSSLGCLEQLHCERNKLKELTLSGFSLRALYASNNCLTSVSVYPVPGQLTCLELSHNELQCVPDWACEAKKLEILDMSYNVLVELPSRILSSLSLRKLIVGYNNLQSLPPLQEHIPMEVLDLQHNLLTKLPETLFVKALNLRYLNASANSLESLPSACTGEESLSMLQLLYLTNNNLTDQCIPVLVGHPNLRILHLANNNLQAFPASKLSKLEHLEELNLSGNKLKTIPTTVANCKLLHTLIAHSNDISIFPEILHLPRIQIVDLSCNELNEILIPEALPAALQELDLTGNTKLVLEHKTLDIFSHITTLKIDSKPSLPTDSALTSTFWSHGVAEMAGQRNKLCVSSLALGSFAEGMEAVYGMFDGDKNEELPRLLQCTMADVLLEEVQKSDTMFMSNTFLVSHRKLGMAGQKLGSSAVLCYIHHDMADSASTFSLTVANVGTCQAVLCRSGKPLLLSKVFSLEQCTEEAKRIKEQKAIITEDNKVNGVTCCTRMLGCTYLHPWILPKPHVSSIPLTVQDELLLLGNKALWEHLSYTEAVSAVRHLHDPLAAAKKLCTLAQSYGCQDNVGAMVVYLNISEDNCTCEMHGLSLPGPGGFSSTTAKTATPSSSSGIASEFGSELSASEVSSEVGSTASDEHNAVGLDGSLLPRQERRCSLHPLLPSSIFQRQPSSATFSSNQSDNGLDSDDEQPVEGVMTNGSKVEVEVDIHCSKGRGLEFDPPALEYSSSAPGVEDDSGLVLVIQRQNSINSTVAHGGVKEKCELQKSPSTCCLYGKKLSNGSIVPLEESLNLIEVATEAPKKKTGYFAAPSQMEPEDQFVMPPDLEEEVKEQMKQQQENGADQEQKEEPAGGLAEEFDTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SZI7</accession>
    <name>A0A8C2SZI7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PITH domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">PITHD1</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PITHD1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015738842.1">
        <property type="nucleotide sequence ID" value="XM_015883356.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SZI7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005008625.1">
        <property type="protein sequence ID" value="ENSCJPP00005005269.1"/>
        <property type="gene ID" value="ENSCJPG00005005097.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107323890"/>
    <dbReference type="KEGG" id="cjo:107323890"/>
    <dbReference type="CTD" id="57095"/>
    <dbReference type="GeneTree" id="ENSGT00490000043398"/>
    <dbReference type="OrthoDB" id="2635at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097598">
        <property type="term" value="C:sperm cytoplasmic droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061956">
        <property type="term" value="P:penetration of cumulus oophorus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007341">
        <property type="term" value="P:penetration of zona pellucida"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045654">
        <property type="term" value="P:positive regulation of megakaryocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061136">
        <property type="term" value="P:regulation of proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007286">
        <property type="term" value="P:spermatid development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.470:FF:000002">
        <property type="entry name" value="PITH domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.470">
        <property type="entry name" value="PITH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045099">
        <property type="entry name" value="PITH1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010400">
        <property type="entry name" value="PITH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037047">
        <property type="entry name" value="PITH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12175">
        <property type="entry name" value="AD039 HT014 THIOREDOXIN FAMILY TRP26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12175:SF1">
        <property type="entry name" value="PITH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06201">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51532">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PITH" evidence="3">
        <location>
            <begin position="21"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00074054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005005269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="212" mass="23645" checksum="36FC8F06449648B2" modified="2022-01-19" version="1">MADGHGHGHGHGAGRCGCCGANGGERGEAWGLHLKIDRGRLQCLNERREGSGARVFRAWEERGDREQFVESDEDAELLFNVPFTGSVKLKAVIVMGEDDGSHPSELRLFKNIPQMSFDDAAREPEQTFNLNPDPVGELEYPTKIARFSNVHDLSMYFPKNFGAETTKIFYIGLKGEWTEGHRHQVTICNYEALPNPGDHQLQPVTPHSRCVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SZW0</accession>
    <name>A0A8C2SZW0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Syntaxin-binding protein 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Lethal(2) giant larvae protein homolog 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Tomosyn-1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">STXBP5</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat L(2)GL family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015713610.1">
        <property type="nucleotide sequence ID" value="XM_015858124.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032299176.1">
        <property type="nucleotide sequence ID" value="XM_032443285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SZW0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005009934.1">
        <property type="protein sequence ID" value="ENSCJPP00005006295.1"/>
        <property type="gene ID" value="ENSCJPG00005005911.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107311558"/>
    <dbReference type="CTD" id="134957"/>
    <dbReference type="GeneTree" id="ENSGT00950000182906"/>
    <dbReference type="OrthoDB" id="19944at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005892">
        <property type="term" value="C:acetylcholine-gated channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098674">
        <property type="term" value="C:extrinsic component of neuronal dense core vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045159">
        <property type="term" value="F:myosin II binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017075">
        <property type="term" value="F:syntaxin-1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045921">
        <property type="term" value="P:positive regulation of exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000300">
        <property type="term" value="P:regulation of synaptic vesicle exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010807">
        <property type="term" value="P:regulation of synaptic vesicle priming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd15893">
        <property type="entry name" value="R-SNARE_STXBP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:003138">
        <property type="entry name" value="Syntaxin binding protein 5 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000001">
        <property type="entry name" value="syntaxin-binding protein 5 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000186">
        <property type="entry name" value="syntaxin-binding protein 5-like isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000664">
        <property type="entry name" value="Lethal2_giant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013905">
        <property type="entry name" value="Lgl_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013577">
        <property type="entry name" value="LLGL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241">
        <property type="entry name" value="LETHAL 2 GIANT LARVAE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241:SF22">
        <property type="entry name" value="SYNTAXIN-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08596">
        <property type="entry name" value="Lgl_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08366">
        <property type="entry name" value="LLGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00962">
        <property type="entry name" value="LETHAL2GIANT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12 18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="9 17" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="17">
        <location>
            <begin position="234"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="20">
        <location>
            <begin position="1087"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="559"/>
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        <location>
            <begin position="675"/>
            <end position="728"/>
        </location>
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        <location>
            <begin position="874"/>
            <end position="908"/>
        </location>
    </feature>
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            <begin position="569"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="582"/>
            <end position="591"/>
        </location>
    </feature>
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        <location>
            <begin position="713"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="877"/>
            <end position="893"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008070"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00081591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1152" mass="127630" checksum="D74A5B60D8B73177" modified="2022-01-19" version="1">MRKFNIRKVLDGLTAVSSAASASSASQQQQAGNRESDIQETLQSEHFQLCKTVRHGFPYQPSALAFDPVQKILAIGTQTGALRLFGRPGVECYCQHDSGAAVIQLQFLINEGALVSALADDTLHLWNLRQKRPAILHSLKFNRERITFCHLPFQSKWLYVGTERGNIHIVNVESFTLSGYVIMWNKAIELSSKSHPGPIVHISDNPMDEGKLLIGFESGTVVLWDLKSKKADYRYTHDEAIHSVAWHHEGKQFICSHSDGTLTIWNVKSPTKPFQTITPHGKQLKDGKKPEPCKPILKVEYKTTRAGEPFIILSGGLSYDTVGRRPCLTVMHGKSTAVLEMDYSIVDFLTLCETPYPNDFQEPYAVVVLLEKDLVLIDLAQNGYPIFENPYPLTIHESPVTCCEYFADCPVDLIPALYSVGARQKRQGYSKKEWPISGGNWGLITQSYPEIIITGHADGSIKFWDASAITLQVLYKLKTAKVFEKSRNKDDRPNTDIVDEDPYAIQIISWCPESRMLCVAGVSAHVIIYRFSKQEVTTEVIPMLEVRLLYEINDIETPDGEQIPPLPTPGTSSNPQSIVPQSHPSTSSSSSDGLRDNVPCLKVKNSPLKQSPGYQIELVIQLVWVSGEPPQQITSLAVNSAYGLVVFGNCNGIAMVDYLQKTVLLNLGTIELYGSNDPYRREPRSPRKTRQPSGAGLCDINEGTVAPEDRCKSPTSGSGSPNSDDDEQKMNNFIEKVKTKSRQFSKMVANDIAKMSRKLSLPTELKPDLDVKDNSFSRSRSSSVTSIDKESREAISALHFCETFTRKADTSPSPCLWVGTTLGTVLVIVLNLPPGGEQRLLQPVIVSPSGTILRLKGAILRMAFLDTTGSLVPPAHEPWREHNVPEDKDEKDKSKKRRPVSVSPSSSQEISENQYAVICSEKQAKVISLPSQNCIYKHNITETSFVLRGDIVSLSNSICLACFCANGHIMAFSLPSLRPLLDVYYLPLTNMRIARTFCFTNNGQALYLVSPTEIQRLTYSQETCENLQEMLGELFTPVETPEAPNRGFFKGLFGGGAQSLDREELFGESASGKASRSLAQHIPGPGGIEGVKGAASGVVGELARARLALDERGQKLGELEEKTAAMLYSADSFSKHAHEMMLKYKDKKWYQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T0H4</accession>
    <name>A0A8C2T0H4_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Microtubule associated protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MAP6</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the STOP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T0H4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005009666.1">
        <property type="protein sequence ID" value="ENSCJPP00005006096.1"/>
        <property type="gene ID" value="ENSCJPG00005005729.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063947"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005798">
        <property type="term" value="C:Golgi-associated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030705">
        <property type="term" value="P:cytoskeleton-dependent intracellular transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048813">
        <property type="term" value="P:dendrite morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032418">
        <property type="term" value="P:lysosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050772">
        <property type="term" value="P:positive regulation of axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070507">
        <property type="term" value="P:regulation of microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007882">
        <property type="entry name" value="MAP6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14759:SF29">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14759">
        <property type="entry name" value="STOP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="40"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="251"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
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        <location>
            <begin position="179"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
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            <begin position="297"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="312"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="369" mass="40807" checksum="B875CBEBAB12374D" modified="2022-01-19" version="1">MAWPCITRACCIARFWNQLDKADIAVPLVFTKYSEATEQPLPTQIPRSAAAPIDTQPGGDAAAAGGGDAAPGPARPGTAPHGSPPADSVMRHDYKPWKVQRPEPSCKPKSEYQPSDTPFEKETQYQKDFRAWPIPKRGDHPWIPKPGPSPVLGPERGSPEKAAQEKRRKKEEEVEADDEHPKAARPGDGREKGRQRGDEAGGQEGRGRAAADALNRQIKEEVVAAGVSSSYRNEFRPWIDVKPVKAIKAKAQYKPPDEKMTHETSYSAQFKGETSKPAPADNKFLERRRIRTLYSEPYKEPPKVEKPSVKPSKPKKTTTSHKPLKKAKDKQIASGRAAKKKSAETSNTTKPEDKEKSKEMNNKLAEAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T0U0</accession>
    <name>A0A8C2T0U0_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thrombospondin type laminin G domain and EAR repeats</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">TSPEAR</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Stereocilium</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T0U0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005009298.1">
        <property type="protein sequence ID" value="ENSCJPP00005005799.1"/>
        <property type="gene ID" value="ENSCJPG00005005484.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00510000047718"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060170">
        <property type="term" value="C:ciliary membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032420">
        <property type="term" value="C:stereocilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008593">
        <property type="term" value="P:regulation of Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007605">
        <property type="term" value="P:sensory perception of sound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009039">
        <property type="entry name" value="EAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005492">
        <property type="entry name" value="EPTP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15261">
        <property type="entry name" value="THROMBOSPONDIN-TYPE LAMININ G DOMAIN AND EAR REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15261:SF4">
        <property type="entry name" value="THROMBOSPONDIN-TYPE LAMININ G DOMAIN AND EAR REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03736">
        <property type="entry name" value="EPTP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50912">
        <property type="entry name" value="EAR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005005799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="593" mass="66549" checksum="3F4CEDC711FF09E8" modified="2022-01-19" version="1">MAEESPGVLVGLRYSPSKLHFLFWSPEHAGGWQNRVTFRNVSLADSRWHTLVLAVSGQSFSLSVDCGLPKDVVVETPFPASLSVKRASFYLGNRRRRKGFFTGLLRQLVLLPGADATPHICTAMNYKATALSIPAVLQDVPVKAVSNEVLKYPHGANMKVTLGSRPPCTKQEKALFWFNASRRGLYLCDGSAWISMLEVKQRLDYVEEYQDLVTNSETMGVEVFTIPRVGLFAATANRHSPPGSAIYKWTDGKFVLYQNIPTYQAQSWKYFTIGKKIFLAVANFEQNDRGQEFSVIYKWSHRKEKFITYQRITTHSARDWEAFVIEGEAFLAVVNHREGNNHNIDSVIYRWNPSTGLFETNQTIPTSGAYDWEFFAIGPYSFLAVANTFNGTSTNIYSHIYIWLSGSFQLFQSILTFGAADWEVFHIGDRVFLAVANSHSYDSRIPAPSNFYAINSSIYELNITAQMFVKFQDLLTYSALDWEFFSVGDDSFLVVANSFDGFTFSINSIIYRYCCMAGSGSLPNLAQPRSWEVPGGTVGGHGYSKGMVWRGHRMGTWGSCCLCSPLLPVFQAQRLSPAPKLLRGGGRRCKAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T159</accession>
    <name>A0A8C2T159_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Superoxide dismutase [Cu-Zn]</fullName>
            <ecNumber evidence="9">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">SOD1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 9">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="9">Binds 1 copper ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Cu-Zn superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="9"/>
    <dbReference type="RefSeq" id="XP_015736733.1">
        <property type="nucleotide sequence ID" value="XM_015881247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T159"/>
    <dbReference type="SMR" id="A0A8C2T159"/>
    <dbReference type="Ensembl" id="ENSCJPT00005008712.1">
        <property type="protein sequence ID" value="ENSCJPP00005005344.1"/>
        <property type="gene ID" value="ENSCJPG00005005140.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107322802"/>
    <dbReference type="KEGG" id="cjo:107322802"/>
    <dbReference type="CTD" id="6647"/>
    <dbReference type="GeneTree" id="ENSGT00940000155551"/>
    <dbReference type="OrthoDB" id="2015551at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904115">
        <property type="term" value="C:axon cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032839">
        <property type="term" value="C:dendrite cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030346">
        <property type="term" value="F:protein phosphatase 2B binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099610">
        <property type="term" value="P:action potential initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008089">
        <property type="term" value="P:anterograde axonal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060088">
        <property type="term" value="P:auditory receptor cell stereocilium organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008340">
        <property type="term" value="P:determination of adult lifespan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035234">
        <property type="term" value="P:ectopic germ cell programmed cell death"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060047">
        <property type="term" value="P:heart contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050665">
        <property type="term" value="P:hydrogen peroxide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007626">
        <property type="term" value="P:locomotory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046716">
        <property type="term" value="P:muscle cell cellular homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002262">
        <property type="term" value="P:myeloid cell homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051093">
        <property type="term" value="P:negative regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050728">
        <property type="term" value="P:negative regulation of inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043524">
        <property type="term" value="P:negative regulation of neuron apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000242">
        <property type="term" value="P:negative regulation of reproductive process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060052">
        <property type="term" value="P:neurofilament cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019228">
        <property type="term" value="P:neuronal action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001541">
        <property type="term" value="P:ovarian follicle development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032287">
        <property type="term" value="P:peripheral nervous system myelin maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001819">
        <property type="term" value="P:positive regulation of cytokine production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902177">
        <property type="term" value="P:positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050766">
        <property type="term" value="P:positive regulation of phagocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032930">
        <property type="term" value="P:positive regulation of superoxide anion generation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008217">
        <property type="term" value="P:regulation of blood pressure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051881">
        <property type="term" value="P:regulation of mitochondrial membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040014">
        <property type="term" value="P:regulation of multicellular organism growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060087">
        <property type="term" value="P:relaxation of vascular associated smooth muscle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048678">
        <property type="term" value="P:response to axon injury"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045471">
        <property type="term" value="P:response to ethanol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042542">
        <property type="term" value="P:response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009410">
        <property type="term" value="P:response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001895">
        <property type="term" value="P:retina homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008090">
        <property type="term" value="P:retrograde axonal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007605">
        <property type="term" value="P:sensory perception of sound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042554">
        <property type="term" value="P:superoxide anion generation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00305">
        <property type="entry name" value="Cu-Zn_Superoxide_Dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.200:FF:000001">
        <property type="entry name" value="Superoxide dismutase [Cu-Zn]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024134">
        <property type="entry name" value="SOD_Cu/Zn_/chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018152">
        <property type="entry name" value="SOD_Cu/Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10003">
        <property type="entry name" value="SUPEROXIDE DISMUTASE CU-ZN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00068">
        <property type="entry name" value="CUZNDISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00087">
        <property type="entry name" value="SOD_CU_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00332">
        <property type="entry name" value="SOD_CU_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="7 9" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-0564">Palmitate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Superoxide dismutase copper/zinc binding" evidence="10">
        <location>
            <begin position="16"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005005344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="154" mass="15690" checksum="F06FEB44E8F2DC00" modified="2022-01-19" version="1">MATLKAVCVMKGDGPVEGVIHFQQQGSGPVKVTGKITGLSDGDHGFHVHEFGDNTNGCTSAGAHFNPEGKQHGGPKDADRHVGDLGNVTAKGGVAEVEIEDSVISLTGPHCIIGRTMVVHAKSDDLGRGGDNESKLTGNAGPRLACGVIGIAKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T1J1</accession>
    <name>A0A8C2T1J1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="27">CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4</fullName>
            <ecNumber evidence="16">2.4.3.2</ecNumber>
            <ecNumber evidence="17">2.4.3.4</ecNumber>
            <ecNumber evidence="23">2.4.3.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="28">Alpha 2,3-sialyltransferase IV</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="30">Gal-beta-1,4-GlcNAc-alpha-2,3-sialyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="29">N-acetyllactosaminide alpha-2,3-sialyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="31">ST3Gal IV</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="32">Sialyltransferase 4C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="35" type="primary">ST3GAL4</name>
    </gene>
    <organism evidence="35 36">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="35" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="35" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="35" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a beta-D-galactosyl-(1-&gt;3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2-&gt;3)-beta-D-galactosyl-(1-&gt;3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21616"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:133470"/>
            <dbReference type="ChEBI" id="CHEBI:139596"/>
            <dbReference type="EC" id="2.4.3.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:21617"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>a beta-D-galactosyl-(1-&gt;3)-N-acetyl-beta-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2-&gt;3)-beta-D-galactosyl-(1-&gt;3)-N-acetyl-beta-D-galactosaminyl derivative + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52380"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:136588"/>
            <dbReference type="ChEBI" id="CHEBI:136589"/>
            <dbReference type="EC" id="2.4.3.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:52381"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>a beta-D-galactosyl-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2-&gt;3)-beta-D-galactosyl-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl derivative + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52316"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:133507"/>
            <dbReference type="ChEBI" id="CHEBI:136545"/>
            <dbReference type="EC" id="2.4.3.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:52317"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>a ganglioside GA1 (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GM1b (d18:1(4E)) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:47560"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:27938"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:78568"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:47561"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>a ganglioside GM1 (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GD1a (d18:1(4E)) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18021"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:77709"/>
            <dbReference type="ChEBI" id="CHEBI:78445"/>
            <dbReference type="EC" id="2.4.3.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:18022"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>a ganglioside GT1c (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GQ1c (d18:1(4E)) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:47588"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:87789"/>
            <dbReference type="ChEBI" id="CHEBI:87791"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:47589"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>a neolactoside nLc4Cer + CMP-N-acetyl-beta-neuraminate = a neolactoside IV(3)-alpha-NeuAc-nLc4Cer + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:65432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:90376"/>
            <dbReference type="ChEBI" id="CHEBI:90390"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:65433"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>a neolactoside nLc4Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a neolactoside IV(3)-alpha-NeuAc-nLc4Cer(d18:1(4E)) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18913"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17006"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:58665"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.4.3.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:18914"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Golgi apparatus</location>
            <location evidence="15">Golgi stack membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 29 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.3.2" evidence="16"/>
    <dbReference type="EC" id="2.4.3.4" evidence="17"/>
    <dbReference type="EC" id="2.4.3.6" evidence="23"/>
    <dbReference type="RefSeq" id="XP_015739486.1">
        <property type="nucleotide sequence ID" value="XM_015884000.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015739487.1">
        <property type="nucleotide sequence ID" value="XM_015884001.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T1J1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005009644.1">
        <property type="protein sequence ID" value="ENSCJPP00005006087.1"/>
        <property type="gene ID" value="ENSCJPG00005005720.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107324198"/>
    <dbReference type="KEGG" id="cjo:107324198"/>
    <dbReference type="CTD" id="6484"/>
    <dbReference type="GeneTree" id="ENSGT00940000158893"/>
    <dbReference type="OrthoDB" id="10264956at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047288">
        <property type="term" value="F:beta-D-galactosyl-(1-&gt;3)-N-acetyl-beta-D-galactosaminide alpha-2,3- sialyltransferase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003836">
        <property type="term" value="F:beta-galactoside (CMP) alpha-2,3-sialyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008118">
        <property type="term" value="F:N-acetyllactosaminide alpha-2,3-sialyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050890">
        <property type="term" value="P:cognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009101">
        <property type="term" value="P:glycoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009312">
        <property type="term" value="P:oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030194">
        <property type="term" value="P:positive regulation of blood coagulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903238">
        <property type="term" value="P:positive regulation of leukocyte tethering or rolling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097503">
        <property type="term" value="P:sialylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd23982">
        <property type="entry name" value="GT29_ST3GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1480.20:FF:000005">
        <property type="entry name" value="ST3 beta-galactoside alpha-2,3-sialyltransferase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1480.20">
        <property type="entry name" value="Glycosyl transferase family 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001675">
        <property type="entry name" value="Glyco_trans_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051142">
        <property type="entry name" value="Glycosyltransferase_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038578">
        <property type="entry name" value="GT29-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13713:SF57">
        <property type="entry name" value="CMP-N-ACETYLNEURAMINATE-BETA-GALACTOSAMIDE-ALPHA-2,3-SIALYLTRANSFERASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13713">
        <property type="entry name" value="SIALYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00777">
        <property type="entry name" value="Glyco_transf_29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11 34" id="KW-0472">Membrane</keyword>
    <keyword evidence="36" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 34" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 34" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="34">
        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="33">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="33">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="33">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00036292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00037859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00039106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00039107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00042448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00043673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00043773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00049726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00051076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00051975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00052660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00072813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00075868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00076295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00076532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00081234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00082801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="35">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="36">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="387" mass="44031" checksum="0E6AFF77FA16FFEE" modified="2022-01-19" version="1">MSKGKRSHQRDGRGREDGPVAPQPLELLPPLLAPRGRTVSGSGCDESPGPRLMPALLIKMINKSRGKILGVLALFLVMVWYSIYREDSFYFPVQENKTVCPIGEVERKAAQLIGNYTRDRPLFLQLKDFFWVRTPSLYELPYGTKGSEDVLLRLLSITSYSLPESIQSLKCRRCVVVGNGHRLRNSSMGDTINTYDVVIRLNNAPVHGYEQDVGSKTTMRLFYPESAHFDPQVENNPDTLLVLVPFKPMDFQWMEAILNDKKRVRKGFWKQPPLIWDANPEQVRILNPYYMEVTAAKLLSLPMKQPRKVKQKPTTGLLAITLALHFCDLVHIAGFGYPDSANKKQTIHYYEQITLKSMAASEHNISHEAVAIKRMLELGLLKNLTYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T253</accession>
    <name>A0A8C2T253_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T253"/>
    <dbReference type="Ensembl" id="ENSCJPT00005009475.1">
        <property type="protein sequence ID" value="ENSCJPP00005005949.1"/>
        <property type="gene ID" value="ENSCJPG00005005621.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00960000189837"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005005949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="108" mass="11828" checksum="22D7038E9A44DE52" modified="2022-01-19" version="1">MAAPSEGRPGRGASSFPGTEGGSFAFPFTVPPGVAGSGAEEQPKKPCRACTDFKSWLREQRKQQGPEMLPCCGCLHIFALPAVGVYRHLNWFLPLHRSKTYSEDKYLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T2L3</accession>
    <name>A0A8C2T2L3_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC107308589</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015708062.1">
        <property type="nucleotide sequence ID" value="XM_015852576.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T2L3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005009569.1">
        <property type="protein sequence ID" value="ENSCJPP00005006018.1"/>
        <property type="gene ID" value="ENSCJPG00005005675.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107308589"/>
    <dbReference type="GeneTree" id="ENSGT00940000165269"/>
    <dbReference type="OrthoDB" id="6581954at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005283">
        <property type="term" value="F:amino acid:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089718">
        <property type="term" value="P:amino acid import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037979">
        <property type="entry name" value="Na_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF318">
        <property type="entry name" value="TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00610">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="8" id="KW-0769">Symport</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="128"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="246"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="293"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="423"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="455"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="499"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="544"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="393"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="396"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="618" mass="67300" checksum="25C9F7281F156BFA" modified="2022-01-19" version="1">MPHSGHLHATGLPAPTAPMEPTVNIFETQGPITPQPWAEPPAPSPPRDTWAGRHTFLLSCLGYCVGLGNVWRFPYLCYRNGGGVFLIPYFLMLILVGLPLFLMELSLGQYGAAGPITVWKCCPILQGVGVGMLVVSSLVSIYYNVIIAWAFYYLGSSFRSPLPWSCDAPRNAELCQNASGNATHASASEAFWNEQVLGVTHSSGLGDPGPVQWLLALCLLAAWLLVFLCMLGGIRSSGKVVYITATFPYLILFVLIIRGATLPGSLDGIRFYLSSDWSKLMSAQVWSDAASQIFYSLGIGFGGLLSMASYNKFDNNVVRDTLVIAIGNCCTSFFAGFAIFSVLGHMALKKDIPVGSVADSGPGLAFVAYPEALSLLPGSPFWSILFFLMLFMLGVDTLFGNIEAITTAIMDEFPALRERGRKMILLGVLCFSFYLLGLLLVTQGGIFWFTLIDTYSTSFGLIIITLLMCVGIVCCYGIGQFCRDIVTMICHCPPWYSRVLGCFKVCWVFLTPCLLLFTLIYTFLEMYSVPLHYGSYEFPAWGTSLGVCMGVLSCVQVPIGAIIALCHQTGTLSDRFHKAMQPLHSWGPPAASTEAVMELPFSITLSDSDFTAPPYSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T2L4</accession>
    <name>A0A8C2T2L4_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="26">Eukaryotic translation initiation factor 2-alpha kinase 3</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">PRKR-like endoplasmic reticulum kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="27">Protein tyrosine kinase EIF2AK3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="31" type="primary">EIF2AK3</name>
    </gene>
    <organism evidence="31 32">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="31" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="31" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="31" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:10597"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="25">Forms dimers with HSPA5/BIP in resting cells. Homotetramerizes in response to endoplasmic reticulum (ER) stress, leading to its activation. Interacts with HSP90B1/GRP94. Interacts with DNAJC3; inhibiting EIF2AK3/PERK activity. Interacts with ATAD3A; ATAD3A and EIF2S1/eIF-2-alpha occupy a common binding site within the cytoplasmic loop of EIF2AK3/PERK, leading to prevent EIF2AK3/PERK association with its substrate EIF2S1/eIF-2-alpha. Interacts with MFN2. Interacts with TMEM33. Interacts with PDIA6. Interacts with LACC1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="20">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2T2L4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005011335.1">
        <property type="protein sequence ID" value="ENSCJPP00005007316.1"/>
        <property type="gene ID" value="ENSCJPG00005006750.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158121"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044233">
        <property type="term" value="C:mitochondria-associated endoplasmic reticulum membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004694">
        <property type="term" value="F:eukaryotic translation initiation factor 2alpha kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019903">
        <property type="term" value="F:protein phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001525">
        <property type="term" value="P:angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070417">
        <property type="term" value="P:cellular response to cold"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042149">
        <property type="term" value="P:cellular response to glucose starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031018">
        <property type="term" value="P:endocrine pancreas development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006983">
        <property type="term" value="P:ER overload response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097250">
        <property type="term" value="P:mitochondrial respirasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001503">
        <property type="term" value="P:ossification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036499">
        <property type="term" value="P:PERK-mediated unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010575">
        <property type="term" value="P:positive regulation of vascular endothelial growth factor production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902235">
        <property type="term" value="P:regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006413">
        <property type="term" value="P:translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd09768">
        <property type="entry name" value="Luminal_EIF2AK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14048">
        <property type="entry name" value="STKc_EIF2AK3_PERK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000251">
        <property type="entry name" value="eukaryotic translation initiation factor 2-alpha kinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000622">
        <property type="entry name" value="Eukaryotic translation initiation factor 2-alpha kinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000193">
        <property type="entry name" value="Eukaryotic translation initiation factor 2-alpha kinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF166">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0013">ADP-ribosylation</keyword>
    <keyword evidence="12 28" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="18" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 28" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="15" id="KW-0346">Stress response</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="17" id="KW-0829">Tyrosine-protein kinase</keyword>
    <keyword evidence="19" id="KW-0834">Unfolded protein response</keyword>
    <feature type="domain" description="Protein kinase" evidence="30">
        <location>
            <begin position="618"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="29">
        <location>
            <begin position="837"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="29">
        <location>
            <begin position="1113"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="29">
        <location>
            <begin position="860"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="29">
        <location>
            <begin position="887"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="binding site" evidence="28">
        <location>
            <position position="647"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00041500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00048977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00051942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00062422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00069562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00078389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005007316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1134" mass="126465" checksum="07A1D874F2B8F071" modified="2022-01-19" version="1">MGALLAVRGRAAAAALPVRGGRAGRPFGSGVVSVHALTAAFKRGPSMRGPRCRSALAALTFLFLLGTAAAGVEEAPQGDAEVVEAAFGLGAAAAALPAGSADVTVEDDVAAAPLGEQEAEGSGEDRSGGRSLVIISTLDGRIAALDPENSGRKQWDLDVGSGSLVSSSLSKPEVFGNKMIIPSLDGDLFQWDRDRESMEAVPFTVESLLESSYKLGEDVVLVGGKSLTSYGLSSYSGKVKYICSAVGCRRWDDDEAEQEDTLLLRRTQKTVRAVGPRSGNEKWNFSVGHFELHYVPDIENRAGYIESNFKLHANKEETKIISDVDEQEAMMKDTVIKVSVADWKVMAFNRQGGHLEWEYQFCTPIASAWLVKDGKVIPISLFDDTSYTTDNEVLEDEEDLVEAARGATESSVYLGMYRGQLYLQSSVRISEKFPTSPKALESRNDNAIIPLPKIKWKPLIHSPSRTPVLVGSDEFDKCLSNDKYSHEEYSNGALSVLQYPYDNGYYLPYYKRERSKRSTQITVRFFDDMNYKTIRKKDPVLLLHWWKEIVGTIIFCIVATTFIVRKLFHPHPYSRLRKESETQCQTDSKYEPACGDVKDTSWSDVKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEGWQEKMDEQWLKDESTDWPLSSPSPMDVPSFKIRTEPFSTKDHIEVIEASSEKGRSFSVGIPRGQSDSSESEFSPLEFFASDNRDLHQSEDPLLNLQDSVLTGCDVEDSTINSNELGHAELDCSLEVCRPAVPVVHLREGTSSSIVFEDSGCGNASSKEDRIDASCDESLSEDKPSTKEPGNKKSSGSPLSVSPPRPTSLSLDLSKNTTEKVKPTSPKVYLYIQMQLCRKENLKDWMSRRCIIEERERTECLQIFLQIAEAVDFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEELVLTPMPAYARHTGQVGTKLYMSPEQICGNTYSHKVDIFSLGLILFELLYPFSTQMERVKTLSDVRNLNFPTLFTQKYAQEYIMVKDMLSPSPTERPEAAAIIENPVFEDLELPAKPVLRQRSRTMSLSGNKHSRQPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T3V6</accession>
    <name>A0A8C2T3V6_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative nuclease HARBI1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC107325557</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T3V6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005010414.1">
        <property type="protein sequence ID" value="ENSCJPP00005006630.1"/>
        <property type="gene ID" value="ENSCJPG00005006176.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163250"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF236">
        <property type="entry name" value="PROTEIN ALP1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="9">
        <location>
            <begin position="373"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="591" mass="66834" checksum="8C8F0224E4C9B509" modified="2022-01-19" version="1">MGHHNTGQARPGPAPLGPAPPAPTSPGKPAATISSRARPARTELPRAAIRSQARPAAPSAVLPARRAQPRSACHRRRPQISRNMAAAAGRKSRPSARGPGRLPVCSGRHIARDLRPAPYRKCLRALSWQRCGLLRSVRPRRGSGPARPSLSLLGAAFTPSTNKPQLKSLDRSGLKMRERLLLLLCALARRRGMAGRWDGPQRRAWLRYYYSQRQKRLMTLLIARRRRTSCYFYPRAWPSLRGADWWERVVLKEFGPQDWLEKFRMTRETFFYVCNRLRPGLAPHSAHFHPTLPLEKRVAVALWHLASNVEYQTLSPLFGVGPSTVQTCVREVSYAVVLLLKPLYLRLPDEKELENMVRIFRTRWGFPHCIGALDSLHIPINPPPRLSADYCNGQGWHSILTQATVDGLGQFWDVSTAFPGSMENSAVLESSSLWVLAKEGRLCPNPPKDFMGKAQKYVLLGDATYPLRDWILKPYREDGSLTRRQLRFNYRLKRAHSVIENAFLRLKARWQILLKCDDCSLELLPTLVLACCVLHNVCEAHDNPFNQDWLEGAEPTELPRPCQPAPTAMEDGRAEQVRELMCQYFESCGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T3W1</accession>
    <name>A0A8C2T3W1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Sorting nexin-19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">SNX19</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Plays a role in intracellular vesicle trafficking and exocytosis. May play a role in maintaining insulin-containing dense core vesicles in pancreatic beta-cells and in preventing their degradation. May play a role in insulin secretion. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)).</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Interacts with PTPRN.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Early endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015739475.1">
        <property type="nucleotide sequence ID" value="XM_015883989.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T3W1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005011069.1">
        <property type="protein sequence ID" value="ENSCJPP00005007131.1"/>
        <property type="gene ID" value="ENSCJPG00005006585.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107324191"/>
    <dbReference type="KEGG" id="cjo:107324191"/>
    <dbReference type="CTD" id="399979"/>
    <dbReference type="GeneTree" id="ENSGT00950000182856"/>
    <dbReference type="OrthoDB" id="5582218at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002062">
        <property type="term" value="P:chondrocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990502">
        <property type="term" value="P:dense core granule maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051649">
        <property type="term" value="P:establishment of localization in cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030073">
        <property type="term" value="P:insulin secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd06893">
        <property type="entry name" value="PX_SNX19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000019">
        <property type="entry name" value="Putative sorting nexin-19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003114">
        <property type="entry name" value="Phox_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037909">
        <property type="entry name" value="SNX19_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013937">
        <property type="entry name" value="Sorting_nexin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775:SF31">
        <property type="entry name" value="SORTING NEXIN-19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08628">
        <property type="entry name" value="Nexin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02194">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00313">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51207">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="5" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="8" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PXA" evidence="16">
        <location>
            <begin position="72"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="15">
        <location>
            <begin position="461"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="264"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="392"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="621"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="704"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="264"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="419"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="637"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00053440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00065455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00071926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005007131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="921" mass="100772" checksum="857131273F72E342" modified="2022-01-19" version="1">MPCRRELLVLGVVLCWLLVLLLDLRVLVLLCGTTAMLGGWLGPRALSRPGWQLRLERFAGSLRPAAPRPEAEKQLEQEISSTIRKVVRDFVSSWYHTVSSECVFEAEVEKAMEGLAAELRRRMVQVDRQALARRLLLLCGHHLQSYLQALQGHGPLWQEYHQITGLHPALSSPTAEVSYARASVELLLRVLVPRPHLETRTGHFVVVELVACNVLLPAIRKMADPDWINLLLVGAFPRKVQGEKPSPAAPMPDALPLTVQPAAAPAVPLPSTSPGQEAGAGGEDGVDVPSEPPCSEGVVLRPRGLGSLFPYEGLEMDSPGRDVELLAPSSAGDFLNEPLIDVPVPLEGTDASEDGMGDLEDGCTTSSDAGLLLPSAYALGSCPDIEIDPLMETEEDSPKKSSVQRPCSLGKELGTPEALPQSPSDPGQPLPLLSSSPTAPISTFSFEPLSSPDGPVVIQNLRITGTITAREHSGTGFHPYTLYTIKYETALEGEVAGSLQQMAYHTVNRRYREFLNLQTRLEEKPELRKFLKNIKGPKKLFPDLPFGNMDSDKVEARKSLLESFLKQLCAVPEIANSEEVQEFLALNTDARIAFVKKPFVVSRIDKIVVNAIVDTLKTAFPRSEPQSPTEDLSESEVDGKCQQDGKKANKSRLRFPSSKITPVLSVSEAHDRIVYSVREGSTVSGTLSLAAMESFIQKQEKLLEAAPSKAPEGEGSEEAKEKSLQEDTDGLSTSEQGAHLDTDSETALADLALDLLRLLLMDHWSWLGMENIQKVFHLLFGTLIQRWLEVQVVNLTCTQRWVQYLRLLQESIWPGGVLPEVPKPARTEEQKKAAAEQALQSLMGILPNVVQEILGTDKCRMSWSLVLESLGHPVINRHLVFCLLDILLEFLVLKGSSDELETTTVVPSDSSGLEKAGGVAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T5C0</accession>
    <name>A0A8C2T5C0_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">SR-related CTD associated factor 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">SCAF8</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015713740.1">
        <property type="nucleotide sequence ID" value="XM_015858254.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005013202.1">
        <property type="protein sequence ID" value="ENSCJPP00005008750.1"/>
        <property type="gene ID" value="ENSCJPG00005007787.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005013203.1">
        <property type="protein sequence ID" value="ENSCJPP00005008751.1"/>
        <property type="gene ID" value="ENSCJPG00005007787.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107311605"/>
    <dbReference type="CTD" id="22828"/>
    <dbReference type="GeneTree" id="ENSGT00530000063946"/>
    <dbReference type="OrthoDB" id="79367at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990269">
        <property type="term" value="F:RNA polymerase II C-terminal domain phosphoserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000805">
        <property type="term" value="P:negative regulation of termination of RNA polymerase II transcription, poly(A)-coupled"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032786">
        <property type="term" value="P:positive regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd17004">
        <property type="entry name" value="CID_SCAF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12462">
        <property type="entry name" value="RRM_SCAF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000004">
        <property type="entry name" value="splicing factor, arginine/serine-rich 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000094">
        <property type="entry name" value="SR-related CTD associated factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034370">
        <property type="entry name" value="SCAF8_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051485">
        <property type="entry name" value="SR-CTD_assoc_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23140">
        <property type="entry name" value="RNA PROCESSING PROTEIN LD23810P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23140:SF1">
        <property type="entry name" value="SR-RELATED CTD ASSOCIATED FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CID" evidence="10">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="478"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="322"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="387"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="758"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1042"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1220"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1293"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="341"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="396"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="448"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="780"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="793"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="870"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="925"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1042"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1072"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1096"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1119"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1228"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1299"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1341"/>
            <end position="1358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005008751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1358" mass="148858" checksum="82C8B6C27F061AE1" modified="2022-01-19" version="1">MEAVKAFNSELYSLNDYKPPISKAKMTQITKAAIKAIKFYKHVVQSVEKFIQKCKPEYKVPGLYVIDSIVRQSRHQFGQEKDVFAPRFSNNIISTFQNLYRCPGDDKSKIVRVLNLWQKNNVFKSEIIQPLLDMAAGIPPPVVTPVLPSTTAAMSNNTPGTPVTPVTPANVVQSLPDPWVSQIANTDTLAAVAQILQSPQGQQLQQLIQTLQIQQQKPQPSLLQALDAGLVVQLQALTAQLTAAAAAANTLNPLEQSVSFNKKLMDRFDFGEESEQNEEPKKETPTSQLPLVPESVNNSLFHQLAEQLQQQNLEHLRQQLLEQQQPQKASPEENQEGNFGSEHSASPSQGSSQQQFLEAETNVDDSMDIQQQDMDIDEAQDVAEEEIFEQEEKKSAVRSRSRTRSRSRSRSPRKRRSRSRSGSRKRKHRKRSRSRSRERKRKSSRSYSSERRAREREKERQKKGLPPIRSKTLSVCSTTLWVGQVDKKATQQDLTNLFEEFGQIESINMIPPRGCAYVCMVHRQDAYRALQKLSSGSYKIGSKIIKIAWALNKGVKTEYKQFWDVDLGVSYIPWEKVKLDDLEGFAEGGMIDQETVNTEWETARSSEPAKENIQTTQSTAVDKSTVITTQTEAYTQPVTMLQIPVAPAVPAVSLVPPAFPVTMSVPPPGYSAIPPPPFLRASFNPSQPPPGFMPPPVPPVVPPPVVPPPVVPPVVPTSLVQPPLPIPQETMKDVPFSGLVLPVVGTVSSNLATPTLSSGSIFNPLPISKQESDEKGSHLTDLQISSSENGRAVQSDVSSSSGLVGGVQPPSVSSSSGLTGEGQPPSVSSSSGLAGGVQPPSVSSSSGLGGGVQPPTVSSSSGLAAGVQLPNVSSSSSLAGGVQPTSVSSSSGLMAGVQPPNVSSSSGLLAGVHPPNISSSPGLLPGMQPPSVSSSSGVLAGVQPPSVSNNSGLLLMPPPNVSSSSGLMGVPPPNISSNSGLLAMQHPAGIQNMPHLNISSQRMPGMPLIDIRPGLMPHSPGPRFPLMQPGIPPQRSIPPPAILDPALHPPPRGPFPPADIFNQTERPFATPGRQNIDSISNPEKRLPLGGDNIQQEGDRDYRFPPVENRDNLNRPSQVDVRDSVGRPPVDPREGIGRPPVDGREHFARPHVDMRENFGRPGIDNLGRREHFAFNSDKHWGQRGDYDEREHHAFPIYGGPKSFHEDRERFRHVNYRFDSRSGPSWNRGFEQDAHRDFDDRRRPWERQRDRDDRDFNFCREINGNRFGRDRMSNNWIPPPHPRVFEYFDGATSQRKADNLPQVNGENTETESQPPTAQVQDDPELYEKLTSSVEINKEKSDTEADIESEPVVESTETEGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T628</accession>
    <name>A0A8C2T628_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T628"/>
    <dbReference type="Ensembl" id="ENSCJPT00005012317.1">
        <property type="protein sequence ID" value="ENSCJPP00005008056.1"/>
        <property type="gene ID" value="ENSCJPG00005007279.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00560000078660"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005008056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="74" mass="8342" checksum="66075AB64D3D99BD" modified="2022-01-19" version="1">MKFQECHSEVMRHGQKIYPSHHRIEMAVEIASLKCQHSSINQSSTRKNSDSTTGRLLWDLLMGIGNSSSNVVLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T6A1</accession>
    <name>A0A8C2T6A1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">hyaluronoglucosaminidase</fullName>
            <ecNumber evidence="4">3.2.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">CEMIP2</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>Random hydrolysis of (1-&gt;4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.</text>
            <dbReference type="EC" id="3.2.1.35"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CEMIP family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.35" evidence="4"/>
    <dbReference type="RefSeq" id="XP_015704598.1">
        <property type="nucleotide sequence ID" value="XM_015849112.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015704599.1">
        <property type="nucleotide sequence ID" value="XM_015849113.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015704600.1">
        <property type="nucleotide sequence ID" value="XM_015849114.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032297157.1">
        <property type="nucleotide sequence ID" value="XM_032441266.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005013196.1">
        <property type="protein sequence ID" value="ENSCJPP00005008744.1"/>
        <property type="gene ID" value="ENSCJPG00005007784.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107306191"/>
    <dbReference type="KEGG" id="cjo:107306191"/>
    <dbReference type="CTD" id="23670"/>
    <dbReference type="GeneTree" id="ENSGT00940000153636"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome Z"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004415">
        <property type="term" value="F:hyalurononglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030214">
        <property type="term" value="P:hyaluronan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd13938">
        <property type="entry name" value="PANDER_like_TMEM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052252">
        <property type="entry name" value="CEMIP/CEMIP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055401">
        <property type="entry name" value="CEMIP_beta-hel_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055400">
        <property type="entry name" value="CEMIP_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019316">
        <property type="entry name" value="G8_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039477">
        <property type="entry name" value="ILEI/PANDER_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039473">
        <property type="entry name" value="TMEM2_PANDER-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15535:SF26">
        <property type="entry name" value="CELL SURFACE HYALURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15535">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24606">
        <property type="entry name" value="CEMIP_beta-hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24605">
        <property type="entry name" value="CEMIP_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10162">
        <property type="entry name" value="G8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15711">
        <property type="entry name" value="ILEI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01225">
        <property type="entry name" value="G8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51484">
        <property type="entry name" value="G8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52031">
        <property type="entry name" value="GG_LECTIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 12" id="KW-0430">Lectin</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="G8" evidence="15">
        <location>
            <begin position="119"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005008744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1381" mass="153259" checksum="9019E536EB2637D2" modified="2022-01-19" version="1">MQDTGARGSSPAFLPPQNGSSHRSSGYVPGRIAPLRPPPPSQSHVSAEFTSARQEARAMFASSPPGQHRRQAEANRHKNTLICFAVSSFSLFVALGIFMGIASKYAPDENCPDQNPRLKNWSPGKDPEKKVVIKKGDLFRLDSDATVHSITIQDGGLLVFGDDKDGSKNITLRTRFILIKDGGMLHVGAEKCRYKSKATIILYGKSNEDADVSEFGKKFIGVGPEGTLELHGQQKLSWTLLSKSVNFSGLACGHYAFKKNFSRGLNVRVIDQDTASVLEVLKFDTHEFSEESLKLQNLLKNRSPGRIIAIAVGDSAAKNLLEETRVTIQNLLGSKFVRGLSYRQAWALVGVIGGGNSSCNESVRDYENHSTGGKALAQKEFFTVDGQKFVVRAYSEWNDGVPISGFQVEPVGGVILNLLDDVSSWEPGDRIVVASTDYSMYQTEEFTLLLCPECTKHQVKVKEKPQYPHIGEVIDGVDMRAEVGVLTRNILIKGETENTCYREKECQFFNYDTFGGHIKILKNFTSVHLSYVELKQMGQQQIGSYPVHFHLCGDVDEKGGYSSKTYLDGLSIHHCFSRCVTIHATNGLLIKDTIGYDTLGHCFFIEDGIEQRNTLFHNLGLVTKPGTILPTDRNSTMCTGIRDKVYGSYVPVPATDCMAVSTFWISHPNNHLISNAAAGSQDAGIWYLFHKVATGDSHSLGIETKSELTPLGIFYNNRVHSNFKAGLFIDKGVKTTNASADDPREYLCLDNNARFRPHQDADPEKPRVAALIDGLISFKNNDHGAWVRGGDILIQNSGFADNGIGLTFASDGSFPNDEGASQVVSESLFIGESKNYGFHGGQNKYSGSGGIDSKVRTLPRNRTFPIRGFQIYDGPIHLTKCTFRNFVPTPDRFTSAIGFLMKNPWQMTPRNNISLVKFGPNVSLKAFFGKPGPWFEEVDLDGDKTSIFHDLDGSVTDYKDTYVGRMDNYLIQHPKCINYTEWNGVICSGTYAQVYVQTWNGQNLSMTIVRDEYPSNPMVLRGINQRAVFQQYQPVVMLQKGYTIHWNGKAPNVTYLYLINFNKNDWIRVGLCYQPNTDFTIVLETFQRKSSALSSKVERYVPVSSMLELEKNRSDKKFYFDNSTGLLFLFLQAKYNRDGHSYCSSQGCERIKIVTKDSAKGVSNCIAKAYPKYYQGPAVIKQMPVKTTVPCTKCGTTQMVFTSDPHKNYLLVQINLSGRKELSRDQQAFISVNNTMFSFKDDGILVVVVDACTGTVSGNNLFSGVDIKRVGGYLKSGIPQRSVVLLSTRGKVEIPSNLSEALKSLGTAKPPYLQSNGSMAFLGFRGNFKPSWIKLFTSPAGHGLIQIEKYIPLQLEEYGCTRAVKSQQKDLELLKKATRSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T6Y8</accession>
    <name>A0A8C2T6Y8_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">REC114 meiotic recombination protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">REC114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T6Y8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005012755.1">
        <property type="protein sequence ID" value="ENSCJPP00005008405.1"/>
        <property type="gene ID" value="ENSCJPG00005007515.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000007235"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042138">
        <property type="term" value="P:meiotic DNA double-strand break formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048477">
        <property type="term" value="P:oogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029168">
        <property type="entry name" value="REC114L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34921">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN REC114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34921:SF1">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN REC114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15165">
        <property type="entry name" value="REC114-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005008405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="260" mass="29203" checksum="3BF71C785EF4A0EA" modified="2022-01-19" version="1">MAACRAGSRCSSQVDGASEQPSGAGSSSLLASATTWPLKRYGRFLSPTDKEDGERSDRSWQVFESNEESGHLILTIVVSGHFFISQGRTVLEGFSLIDSQKWLRIARRADCLLLHAQSKQNECRMFRVQFGGDSEEQTLEHCCSCVQKLTEYVPVHEADELSQNLCYSHSQVEDTEQNTSALHVADEPLPDSFTNFGERRSTMQLAQSVLSHELELPLVYRHSAWSARDLGPFIRLCLMDQHFPAFVEDVEKELKKLTEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T7J7</accession>
    <name>A0A8C2T7J7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Aminopeptidase</fullName>
            <ecNumber evidence="23">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="28" type="primary">ENPEP</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="28" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="28" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of N-terminal glutamate (and to a lesser extent aspartate) from a peptide.</text>
            <dbReference type="EC" id="3.4.11.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="21 23">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="21 23">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer; disulfide-linked.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 23">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="23"/>
    <dbReference type="RefSeq" id="XP_015717477.1">
        <property type="nucleotide sequence ID" value="XM_015861991.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T7J7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005011535.1">
        <property type="protein sequence ID" value="ENSCJPP00005007441.1"/>
        <property type="gene ID" value="ENSCJPG00005006861.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107313605"/>
    <dbReference type="KEGG" id="cjo:107313605"/>
    <dbReference type="CTD" id="2028"/>
    <dbReference type="GeneTree" id="ENSGT00940000156946"/>
    <dbReference type="OrthoDB" id="510539at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005903">
        <property type="term" value="C:brush border"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004230">
        <property type="term" value="F:glutamyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001525">
        <property type="term" value="P:angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002003">
        <property type="term" value="P:angiotensin maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008283">
        <property type="term" value="P:cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032835">
        <property type="term" value="P:glomerulus development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.50.20:FF:000001">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000006">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1910:FF:000003">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000016">
        <property type="entry name" value="Glutamyl aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF276">
        <property type="entry name" value="GLUTAMYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 23" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="12" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="18" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 23" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 21 23" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15 23" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="7 23" id="KW-0645">Protease</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="8 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11 21 23" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="27">
        <location>
            <begin position="89"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="25">
        <location>
            <begin position="312"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="26">
        <location>
            <begin position="604"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="44"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="19">
        <location>
            <position position="385"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="348"/>
            <end position="352"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="384"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="388"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="874"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="22">
        <location>
            <position position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="RuleBase" id="RU364040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005007441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="943" mass="107837" checksum="5B48ADFA95AED4B9" modified="2022-01-19" version="1">MEDMDFEDKKSKKYCIKTKHVAIICGVVAVVGLAVGLGVGLSKRQPSPEYSDQPDQPATSPPTVNAGPCPAKSDDSGDWRNFRLPTYVKPIHYDLEVKPEMDTDIYTGTVNISIALGQSTSHLWLHLRETKITEMPTLRKSSGQQIALTDCFEYKAQEYIVMKAEAALTVTDESDPYILTLKFQGWLNGSLVGFYRTTYTEKGVTKSIAATDHEPTDARKSFPCFDEPNKKATYSISIVHQDKYGALSNMPVQETVSLGNGWNRTTFQKSVPMSTYLVCFAVHQFQWVERTSASGIPLRVYAQPQQLHTAEYAANVTKKVFDYFEEYFNLSYSLPKLDKIAIPDFGTGAMENWGLITYRETNLLYDPNESASSNQQRVAAVVAHELVHQWFGNIVTMEWWNDLWLNEGFASYFEYLGVNASEPDWQMLEQVLIDDVLPVMKDDSLLSSHPIVVDVSTPAEITSVFDGISYSKGASILRMLRDWITPELFQKGCQAYLKNHHFQNAKTQHFWEALEMASNKPVSEVMDTWTRQMGYPVLEMGNNSVFTQKRFLLDPNADISSPPSDLGYKWNIPVKWGLGNSTNYMFYNTSDSAGITITSTANSFLNVNPDHIGFYRVKYDSQNWATLSTSLVNNHETFSAADRAGILDDAFSLARAGLVDYSVPLDLTRYLINETHYLPWHRAISAVTYIADMLEDDTNLYLRFQEYFRYLVKPIVNKLSWSDTGSHLDRLLRASVLDFACSMNDAESLKNASQQFEQWLQGQTIAVNLRLLVYRYGMQNSGNESSWNYMFEKYQETPLAQEKEKLLYGLASVTNITLLDRYLKYVYNSSLIKSQDVFTVLRYISYNMYGKTMAWDWIRLNWEYLVGRFTINDRNLGRIVTISQNFNTDLQLWQMENFFEKYPNAGAGELPRSQSIEQVKNNIQWLKENKEEIQMWLEAWTGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TB05</accession>
    <name>A0A8C2TB05_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">F-box only protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FBXO9</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins and acts as a regulator of mTOR signaling.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO9).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TB05"/>
    <dbReference type="Ensembl" id="ENSCJPT00005013339.1">
        <property type="protein sequence ID" value="ENSCJPP00005008858.1"/>
        <property type="gene ID" value="ENSCJPG00005007854.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000014256"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990756">
        <property type="term" value="F:ubiquitin-like ligase-substrate adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045444">
        <property type="term" value="P:fat cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904037">
        <property type="term" value="P:positive regulation of epithelial cell apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070936">
        <property type="term" value="P:protein K48-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032006">
        <property type="term" value="P:regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22089">
        <property type="entry name" value="F-box_FBXO9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.50:FF:000012">
        <property type="entry name" value="F-box only protein 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045464">
        <property type="entry name" value="Hrt3/FBXO9_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12874">
        <property type="entry name" value="F-BOX ONLY PROTEIN 48-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12874:SF29">
        <property type="entry name" value="F-BOX ONLY PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19270">
        <property type="entry name" value="FBO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="8">
        <location>
            <begin position="211"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="120"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005008858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="474" mass="53917" checksum="5027BD7D788B932A" modified="2022-01-19" version="1">MAARAGLRLPAASAPQDRVGGSGRPQDRAAQRGRAGGRGARSGAGVRARGWCRPAPHVGRRSGPAGSCVEPCPPLALRLPLTRREDGCRTPGPQLLPLRGALLRPRTLLICPAGTTRGPSRGDRGPRDGTAPAERRQHAIKFYRLAMQLVPDIEFKIAYTRSPDGDGVGKRCVDDNEEDGKMADLLSDFQQQLTLQESSVKLCQPELDVNQTHISALPLEVLMYIFRWVVSSDLDLRSLEQLSLVCRGFYICARDPEIWHQVCLKVWGRSCNKLVPYSSWREMFLERPRVRFDGVYISKTTYIRQGEQSLDGFYRAWHQVEYYRYLRFFPDGQVMMLTTPEDPQSIVPRLRTKNARVDAVLLGHYRLSQETDNQTKVFAVIMKKKEEKPVDYHKYRYFRRVPVQETEHSFHVGLQLCSSGRQTFNKLVWIHHSCHITYKSTGETAVTTFDIDKMYTPLFFARVKSYTAFSEKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TBM2</accession>
    <name>A0A8C2TBM2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA-binding protein 48</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">RBM48</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RBM48 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015709015.1">
        <property type="nucleotide sequence ID" value="XM_015853529.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TBM2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005016540.1">
        <property type="protein sequence ID" value="ENSCJPP00005011299.1"/>
        <property type="gene ID" value="ENSCJPG00005009712.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107309073"/>
    <dbReference type="KEGG" id="cjo:107309073"/>
    <dbReference type="CTD" id="84060"/>
    <dbReference type="GeneTree" id="ENSGT00390000004541"/>
    <dbReference type="OrthoDB" id="78358at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12442">
        <property type="entry name" value="RRM_RBM48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000424">
        <property type="entry name" value="RNA-binding protein 48 isoform X4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039599">
        <property type="entry name" value="RBM48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034264">
        <property type="entry name" value="RBM48_RRM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20957">
        <property type="entry name" value="RNA-BINDING PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20957:SF0">
        <property type="entry name" value="RNA-BINDING PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="155"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="196"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="327"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="217"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="328"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005011299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="352" mass="39308" checksum="B50C2630E0D539F4" modified="2022-01-19" version="1">MAAGGAGGPGEACRHHQQLGACGSRAKYREGRRPRAVKVYTINLESRYLLIQGVPALGVMKELVEQFALYGAIEEYHALDEYPAEQFTEVYLIKFQNLQCARVAKKKMDERSFFGSLLHVCYAPEFETVQETREKLQDRRKYIAKATNQRDCFLLKKTERPRRTKSDSQWSTPGSHAATHWDPSCFPVPHGLSQNMEYPSGNHSQDLLAFPHCDNPSAETSGNSSQSSSLTQKAHPGGCAAPVPLIQQRTVPADNGIDRFMPRTTHLQERKRKREEGNKCALTETNVDSTDIVIGPQLPEVPQVDMDDDSLNTSAMLIRNKLKEVAESVSNTSVEKPGSSATKPLVKQRRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TBQ8</accession>
    <name>A0A8C2TBQ8_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">inorganic diphosphatase</fullName>
            <ecNumber evidence="4">3.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">PPA1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2TBQ8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005016469.1">
        <property type="protein sequence ID" value="ENSCJPP00005011230.1"/>
        <property type="gene ID" value="ENSCJPG00005009683.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000017004"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00412">
        <property type="entry name" value="pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.80.10:FF:000005">
        <property type="entry name" value="Pyrophosphatase (inorganic) 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.80.10">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008162">
        <property type="entry name" value="Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10286">
        <property type="entry name" value="INORGANIC PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00719">
        <property type="entry name" value="Pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50324">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00387">
        <property type="entry name" value="PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005011230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="425" mass="47025" checksum="72AB39EF71E7575B" modified="2022-01-19" version="1">MSPSPHFPSPCRPLWGAQPWQSGPHHSMPLWPHGATLQRGHAPSRCSAMTDSTAHTVTHTRPMPAPSPRPAAPRHGSAQTQGRVTALRSCAVCSGAGLKGRGAGLWAGLWALLWAGGCGQRRLRIEPSGQRQRGAMAGYSVEERAAPHSIEYRLFFKDAAGRYISPFHDIPLYADAGKNVFNMVVEVPRWTNAKMEIATKDPLNPIKQDVKKGKLRYVANVFPHKGYIWNYGAIPQTWEDPGHKDENTGCCGDNDPIDVCEIGSKVCSRGEVIKVKVLGTLAMIDEGETDWKIIAINMEDPEAENYNDIDDVRRMKPGYLEATVDWFRRYKVPDGKPENQFAFNGEFKDKDFAVNVIKSTHEHWKALIAKKTDGGEICCTNLTVSGSPFCCSQECAKATVDAAPPCKAANPIPPEVDRWFYYQKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TGE0</accession>
    <name>A0A8C2TGE0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Kappa-type opioid receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">OPRK1</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">G-protein coupled opioid receptor that functions as a receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as a receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Interacts with NHERF1. Interacts with GABARAPL1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015711145.1">
        <property type="nucleotide sequence ID" value="XM_015855659.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TGE0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005017707.1">
        <property type="protein sequence ID" value="ENSCJPP00005012198.1"/>
        <property type="gene ID" value="ENSCJPG00005010383.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107310212"/>
    <dbReference type="KEGG" id="cjo:107310212"/>
    <dbReference type="CTD" id="4986"/>
    <dbReference type="GeneTree" id="ENSGT00940000157341"/>
    <dbReference type="OrthoDB" id="6076970at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038048">
        <property type="term" value="F:dynorphin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042923">
        <property type="term" value="F:neuropeptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031635">
        <property type="term" value="P:adenylate cyclase-inhibiting opioid receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007626">
        <property type="term" value="P:locomotory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007218">
        <property type="term" value="P:neuropeptide signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046877">
        <property type="term" value="P:regulation of saliva secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019233">
        <property type="term" value="P:sensory perception of pain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd15091">
        <property type="entry name" value="7tmA_Kappa_opioid_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000014">
        <property type="entry name" value="Kappa-type opioid receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000452">
        <property type="entry name" value="Kappa_opi_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001418">
        <property type="entry name" value="Opioid_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24229:SF1">
        <property type="entry name" value="KAPPA-TYPE OPIOID RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24229">
        <property type="entry name" value="NEUROPEPTIDES RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00532">
        <property type="entry name" value="KAPPAOPIOIDR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00384">
        <property type="entry name" value="OPIOIDR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0085">Behavior</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 17" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0564">Palmitate</keyword>
    <keyword evidence="11 17" id="KW-0675">Receptor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 17" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 17 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="220"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="273"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="20">
        <location>
            <begin position="77"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="369"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00043871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005012198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="381" mass="43150" checksum="CE4DCC2B759E5C69" modified="2022-01-19" version="1">MDAPVQIFRDELDSTCVPGPCQPSSTSSSWTLGWVDYDSNATGNFEDTQHNHTSISPSIPIIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLAMADALVTTTMPFQSTEYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDTASTECSLQFPDRDYVWWDIFMKICVFVFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFIICWTPIHIFVLVEALGDVSHSTAAVSSYYFCIALGYTNSSLNPILYAFLDENFKRCFKDFCFPFKMRMDRQSTSRVRNTVQDPAYRREADGTNKPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TGK5</accession>
    <name>A0A8C2TGK5_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type proton ATPase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ATP6V0D1</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the V-ATPase V0D/AC39 subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TGK5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005019207.1">
        <property type="protein sequence ID" value="ENSCJPP00005013357.1"/>
        <property type="gene ID" value="ENSCJPG00005011251.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000002200"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016471">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036295">
        <property type="term" value="P:cellular response to increased oxygen levels"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1690.10:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1690.10:FF:000002">
        <property type="entry name" value="V-type proton ATPase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036079">
        <property type="entry name" value="ATPase_csu/dsu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002843">
        <property type="entry name" value="ATPase_V0-cplx_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016727">
        <property type="entry name" value="ATPase_V0-cplx_dsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11028">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01992">
        <property type="entry name" value="vATP-synt_AC39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018497">
        <property type="entry name" value="V-ATP_synth_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103486">
        <property type="entry name" value="V-type ATP synthase subunit C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR018497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005013357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="385" mass="44149" checksum="4CE3B9AA55DFAA57" modified="2022-01-19" version="1">MSCFPELYFNVDNGYLEGLVRGFKAGVLRQGDYVNLVQCESLEDLKLHLQSTDYGNFLANEASPLTVSVIDDKLKEKMVVEFRHMRNHAYEPLASFLDFITPLGCMQQSEASLPSSPVVRTARCYFICFLFHPCRYSYMIDNVILLITGTLHQRSISELVPKCHPLGSFEQMEAVNIAQTPAELYNAILVDTPLAAFFQDCISEQDLDEMNIEIIRNTLYKAYLESFYKFCKALGGTTADAMCPILEFEADRRAFIITINSFGTELSKEDRAKLFPHCGKLYPEGLAQLARADDYEQVKNVADYYPEYKLLFEGAGSNPGDKTLEDRFFEHEVKLNKLAFLNQFHFGVFYAFVKLKEQECRNIVWIAECIAQRHRTKIDNYIPIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2THA1</accession>
    <name>A0A8C2THA1_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Sodium voltage-gated channel beta subunit 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">SCN4B</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2THA1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005019734.1">
        <property type="protein sequence ID" value="ENSCJPP00005013775.1"/>
        <property type="gene ID" value="ENSCJPG00005011577.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234556"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014704">
        <property type="term" value="C:intercalated disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001518">
        <property type="term" value="C:voltage-gated sodium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017080">
        <property type="term" value="F:sodium channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044325">
        <property type="term" value="F:transmembrane transporter binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0086006">
        <property type="term" value="F:voltage-gated sodium channel activity involved in cardiac muscle cell action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0086016">
        <property type="term" value="P:AV node cell action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0086002">
        <property type="term" value="P:cardiac muscle cell action potential involved in contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051649">
        <property type="term" value="P:establishment of localization in cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019228">
        <property type="term" value="P:neuronal action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010765">
        <property type="term" value="P:positive regulation of sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0086091">
        <property type="term" value="P:regulation of heart rate by cardiac conduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060307">
        <property type="term" value="P:regulation of ventricular cardiac muscle cell membrane repolarization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000920">
        <property type="entry name" value="Myelin_P0-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13869">
        <property type="entry name" value="MYELIN P0 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13869:SF14">
        <property type="entry name" value="SODIUM CHANNEL SUBUNIT BETA-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="46"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="196"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="199"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005013775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="224" mass="24074" checksum="D05D6AB1CE88519C" modified="2022-01-19" version="1">ARGGGGGSLSPCCWGEHQCGGLYILAIAFALEVSVGKTNTVMALNGSDVLLPCTFTTCIGFQDLIFTWYFNSTELIYHGKIKSKTSEPILVGRNPRVEFVGSTTGKDNNISIVLKDVELSDAGRYTCHVLNPKEKKAQHNATIFLTVVHKMEETDNTVTLIIVGVVGGLIGLLILFMLVKRVVLFIIKKTQDGKKECLVSSSGNDNTENGLAGSKAEQKAPPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TI39</accession>
    <name>A0A8C2TI39_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Anterior gradient 3, protein disulphide isomerase family member</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">AGR3</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AGR family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015709161.1">
        <property type="nucleotide sequence ID" value="XM_015853675.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TI39"/>
    <dbReference type="Ensembl" id="ENSCJPT00005020271.1">
        <property type="protein sequence ID" value="ENSCJPP00005014195.1"/>
        <property type="gene ID" value="ENSCJPG00005011876.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005020274.1">
        <property type="protein sequence ID" value="ENSCJPP00005014198.1"/>
        <property type="gene ID" value="ENSCJPG00005011876.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107309148"/>
    <dbReference type="KEGG" id="cjo:107309148"/>
    <dbReference type="CTD" id="155465"/>
    <dbReference type="GeneTree" id="ENSGT00530000063273"/>
    <dbReference type="OrthoDB" id="262308at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002162">
        <property type="term" value="F:dystroglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd02960">
        <property type="entry name" value="AGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000036">
        <property type="entry name" value="anterior gradient protein 2 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051099">
        <property type="entry name" value="AGR/TXD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15337:SF5">
        <property type="entry name" value="ANTERIOR GRADIENT PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15337">
        <property type="entry name" value="ANTERIOR GRADIENT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13899">
        <property type="entry name" value="Thioredoxin_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044679384" evidence="3">
        <location>
            <begin position="23"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005014195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="165" mass="19010" checksum="251DA0A1E09C80C2" modified="2022-01-19" version="1">MLHSTLALSLLLIAVSSNLAMAIKKEKKAPQTLSRGWGDEITWVQTYEEGLYQAKKSNKPLMVIHHLEDCQYCQALKKAFAENEEIQEMAQDSFIMLNLMHETTDKNLSPDGQYVPRIMFIDPSLTVRADITGRYSNRLYTYEPQDIPFLIENMKKALRLIQTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TI48</accession>
    <name>A0A8C2TI48_COTJA</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized LOC107311139</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="primary">LOC107311139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015712905.1">
        <property type="nucleotide sequence ID" value="XM_015857419.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TI48"/>
    <dbReference type="Ensembl" id="ENSCJPT00005017355.1">
        <property type="protein sequence ID" value="ENSCJPP00005011919.1"/>
        <property type="gene ID" value="ENSCJPG00005010188.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107311139"/>
    <dbReference type="KEGG" id="cjo:107311139"/>
    <dbReference type="GeneTree" id="ENSGT00390000001612"/>
    <dbReference type="OrthoDB" id="6435011at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41142">
        <property type="entry name" value="SI:DKEY-16J16.4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41142:SF1">
        <property type="entry name" value="SI:DKEY-16J16.4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005011919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="272" mass="30626" checksum="1ED394EFE3FFB3B9" modified="2022-01-19" version="1">MLKVLTKKLRNQTLNEIQPFQLKISYPPSDEDSDDSEGENQELVQIDRERRRNCTLTPLATNQLQNQENQCCKVRALLHASLDRHSSEEELERINREFAAEKRKWSQVSRLACCSDSNNTSSSDEEVKNLCAMSFQPVAEQADGLHASPSPVLFSASPPKRLQPLVRNPASRPLILTGVGAGLEQVMPCKRHRQGYGDKICRPSLDLEKMQQKMLLKKNCGMKTRVIKIRSINGGRPPPHFVYDPSTFAFRSLSTLKPLSPIAPVEEPSCAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TIT8</accession>
    <name>A0A8C2TIT8_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">BCR activator of RhoGEF and GTPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BCR</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Axon</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Dendritic spine</location>
        </subcellularLocation>
    </comment>
    <dbReference type="Ensembl" id="ENSCJPT00005018953.1">
        <property type="protein sequence ID" value="ENSCJPP00005013148.1"/>
        <property type="gene ID" value="ENSCJPG00005009635.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153491"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043197">
        <property type="term" value="C:dendritic spine"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098685">
        <property type="term" value="C:Schaffer collateral - CA1 synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071222">
        <property type="term" value="P:cellular response to lipopolysaccharide"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060216">
        <property type="term" value="P:definitive hemopoiesis"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048041">
        <property type="term" value="P:focal adhesion assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048872">
        <property type="term" value="P:homeostasis of number of cells"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042472">
        <property type="term" value="P:inner ear morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030216">
        <property type="term" value="P:keratinocyte differentiation"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:macrophage migration"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:modulation of chemical synaptic transmission"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:regulation of cell cycle"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:regulation of Rho protein signal transduction"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043114">
        <property type="term" value="P:regulation of vascular permeability"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003014">
        <property type="term" value="P:renal system process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="C2_ABR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13367">
        <property type="entry name" value="PH_BCR_vertebrate"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RhoGAP_Bcr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="active breakpoint cluster region-related protein isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="active breakpoint cluster region-related protein-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Bcr-Abl oncoprotein oligomerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Abr/Bcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015123">
        <property type="entry name" value="Bcr-Abl_oncoprot_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036481">
        <property type="entry name" value="Bcr-Abl_oncoprot_oligo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
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        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
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        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
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        <property type="entry name" value="BREAKPOINT CLUSTER REGION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Bcr-Abl_Oligo"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DBL homology domain (DH-domain)"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0770">Synapse</keyword>
    <feature type="domain" description="DH" evidence="10">
        <location>
            <begin position="512"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="8">
        <location>
            <begin position="720"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="9">
        <location>
            <begin position="905"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="11">
        <location>
            <begin position="1066"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="81"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="332"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="467"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="134"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="357"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="380"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="473"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005013148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1283" mass="146014" checksum="47F65165E413ACAD" modified="2022-01-19" version="1">MVDPVGFVEAWKAQFADSEPPKMDLKSVGDIEQELEMCKASIRRLEMEVNKERFRMIYLQTLLAKEKKSYDRQRWGFKRASQLPEGGADQQIRDLPHPHDGSDLVVENTESRCDADGSPSKHRSSSTRRLVGSAEKEGLFEPISKDRGNSTSVAALRSNFERIKKGNSHHSGDNKDVVEKPFYVNMEYHHEKGLVKVNDKDVSDKISSLGSQAMQMERKKSLHSLPSSVAPSFNELQRPAYRGRSSESSFGYDGEYEDAELNPRFLKDNLINANGSNRSPWQPMDFQPYQSIYVGGMMGETEGKGPIMRNQGMGDLEKHLTWPRRSYSPRSFEDIGGGYTPDCSSNENLTSSEEDFSSGQSSHISPSPTTYRMYRDKSRSPSQNSQQSFDSSSPPTPQSQKRHRQQQVIVSEATIVGVRKTGQIWPSDGDLQIFLPCFADASCSGTPPSYAYDADRAEEQRRHHDMMPYIDDSPSSSPHLSSKSRGSRDTLSSGSLESTKSSEPDLEKGLEMRKWVLSGILASEETYLSHLEALLLPMKPLKAAATTSQPVLTSQQIETIFFKVPELYEIHKEFYDGLFPRVQQWSHQQRVGDLFQKLASQLGVYRAFVDNYEVAMETAEKCCQANAQFAEISEGLHLGTFFFMFLLWFFFTALLYKPVDRVTRSTLVLHDLLKHTPVSHPDHPLLQDALRISQNFLSSINEEITPRRQSMTVKKGEHRQLLKDSFMVELVEGARKLRHVFLFTDLFLCAKLKKQIGGKSQKYDCKWYIPLTDLSFQMVDESEAVPNIPLVPDEELDAMKIKISQIKNDIQREKRANKGSKVIERLKKKLSEQESLLLLMSPSMAFRVHNRNGKSYTFLISSDYERAEWRENIREQQKKCFKSFSLTSVELQMLTNSCVKLQTVHNIPLTINKEDDESPGLYGFLNVIVHSAAGFKQSSNLYCTLEVDSFGYFVNKAKTRVYRDTTEPNWNEEFEIELEGSQTLRILCYEKCYNKMKLTKEDGESTDRIMGKGQIQLDPQTLQDKDWQRTVISMNGVEVKLSVKFTSREFSLKRMPSRKQTGVFGVKIAIVTKRERSKVPYIVRQCVEEIERRGMEEVGIYRVSGVATDIQALKAAFDVNNKDVSVMMSEMDVNAIAGTLKLYFRELPEPLFTDELYPNFAEGIALSDPVAKESCMLNLLLSLPEPNLVTFLFLLDHLKRVAERESINKMSLHNLATVFGPTLLRPSEKDSKIPANPTQPITMTDSWSLEVMSQVQVLLYFLQLETIPTPDSKRQSILFSTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TJ89</accession>
    <name>A0A8C2TJ89_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Hyaluronidase</fullName>
            <ecNumber evidence="6">3.2.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">HYAL3</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Random hydrolysis of (1-&gt;4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.</text>
            <dbReference type="EC" id="3.2.1.35"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glycosyl hydrolase 56 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.35" evidence="6"/>
    <dbReference type="RefSeq" id="XP_015730131.1">
        <property type="nucleotide sequence ID" value="XM_015874645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TJ89"/>
    <dbReference type="Ensembl" id="ENSCJPT00005020873.1">
        <property type="protein sequence ID" value="ENSCJPP00005014693.1"/>
        <property type="gene ID" value="ENSCJPG00005012238.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107319647"/>
    <dbReference type="KEGG" id="cjo:107319647"/>
    <dbReference type="CTD" id="8372"/>
    <dbReference type="GeneTree" id="ENSGT01020000230364"/>
    <dbReference type="OrthoDB" id="5796153at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002080">
        <property type="term" value="C:acrosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097225">
        <property type="term" value="C:sperm midpiece"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033906">
        <property type="term" value="F:hyaluronoglucuronidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004415">
        <property type="term" value="F:hyalurononglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051216">
        <property type="term" value="P:cartilage development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071347">
        <property type="term" value="P:cellular response to interleukin-1"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071356">
        <property type="term" value="P:cellular response to tumor necrosis factor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071493">
        <property type="term" value="P:cellular response to UV-B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030214">
        <property type="term" value="P:hyaluronan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000355">
        <property type="term" value="P:negative regulation of ovarian follicle development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001552">
        <property type="term" value="P:ovarian follicle atresia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007341">
        <property type="term" value="P:penetration of zona pellucida"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000368">
        <property type="term" value="P:positive regulation of acrosomal vesicle exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009615">
        <property type="term" value="P:response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000065">
        <property type="entry name" value="Hyaluronidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018155">
        <property type="entry name" value="Hyaluronidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11769">
        <property type="entry name" value="HYALURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11769:SF19">
        <property type="entry name" value="HYALURONIDASE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01630">
        <property type="entry name" value="Glyco_hydro_56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00846">
        <property type="entry name" value="GLHYDRLASE56"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EGF-like" evidence="8 9">
        <location>
            <begin position="489"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="517"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU610713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS01186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005014693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="538" mass="59444" checksum="98E076D629A0062E" modified="2022-01-19" version="1">MAAGRSGERPALNRDQCCLCCVMRPPNPQLAAGTGQQHAALLPLPMCDGPGGSTLPPNRDEAAAVPLLGGRLRARRGTETPGRTWLRALQDFGCPPAALSPQAVPLGMGLVLALWTWLVLGTASGESPVPTALAGAQPFAVLWNIPSSRCQRRFGVGLPLADYGIVENEGGRFAGQNITIFYKNKFGLYPYISPQGDLHNGGIPQRAPLRAHLARVAGDVRLHLRPSFSGLAVLDWEEWRPLWARNWGPKRIYQLASQQWAQERGGGRRQARRAFERAARALMEQTLRLSRSLRPAGLWGFYRFPDCFNGDWNKGLNYTGRCRPAEVRRNDRLRWLWAASAALYPSIYLPPLLPPGLRRRYVHHRLREALRLAAGRLPVVAYSRLSYRRSPRFLEPADLEHTIGESAALGVAGVVLWGDMSYSHSAESCSSLRHYLVSTLGPYVANVTAAAQTCSLEQCHGHGRCVRRQPQELSILLHLGAGSWAPFRCHCYRGWAGQDCTQPEPRSPTACPTPTHSLYGHHSPQAPDTCPRRSSWGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TJB9</accession>
    <name>A0A8C2TJB9_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Plastin 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">PLS1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
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        <scope>IDENTIFICATION</scope>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
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        <name type="synonym">Coturnix coturnix japonica</name>
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            <taxon>Vertebrata</taxon>
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            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
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            <taxon>Saurischia</taxon>
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            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
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                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
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        <scope>IDENTIFICATION</scope>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
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        <property type="entry name" value="CLATHRIN INTERACTOR 1"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="2">
        <location>
            <begin position="16"/>
            <end position="149"/>
        </location>
    </feature>
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        <location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="PROSITE" id="PS50942"/>
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        </source>
    </evidence>
    <sequence length="648" mass="70972" checksum="5E52CB50359BE025" modified="2022-01-19" version="1">MLNMWKVRELVDKATNVVMNYSEIESKVREATNDDPWGPSGQLMGEIAKATFMYEQFPELMNMLWTRMLKDNKKNWRRVYKSLLLLAYLIRNGSERVVTSAREHIYDLRSLENYHFVDENGKDQGINIRQKVKEMVEFAQDDDRLREERKKAKKNKDKYIGVSSDSVGGFRYSERYDPEPKSKWDEDWDKKSSFPFSDKLGELSDKIGSTIDDTISKFRRKDREDSPERCSDSDEEKSRRSKSPKAEFKNEEETVTTKHIHITQATEIITSRHKRSANPSKTIDLGAAAHYTGDKASPEQNAASHAGQPTAKVSGSKSSNDLVDLLFDGASQPVATDVSTDPFGGFADFSSAAASASFPSSQGTTTSGNGDFGDWSAFNQASPCPSASSGELFSSSAQQPAIELFSVSQPASGQPPAASNSTDLFDLMGPSQTTMTSSQSMNFCMMNSNAVGIGLPMSRSQPLQSVNTMMPKPNSLYNASTEVQKSASKTLPATWSDPSVNISLDNLVPGMQPSKPQQPSLNTMMQQQNMQQPMNVMTQNFAAVNLNPQPNMMPVRPQTSPLMGGSIPVGMGMPSVMPGTMGMTSMGPMPMLNQGTMGMNMNMGVPATGMGLTGTIGMGITNISMTSMTPGTVQPKQDAFANFANFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TM11</accession>
    <name>A0A8C2TM11_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Glycoprotein IX platelet</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">GP9</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TM11"/>
    <dbReference type="Ensembl" id="ENSCJPT00005022046.1">
        <property type="protein sequence ID" value="ENSCJPP00005015566.1"/>
        <property type="gene ID" value="ENSCJPG00005012877.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000064244"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990779">
        <property type="term" value="C:glycoprotein Ib-IX-V complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007597">
        <property type="term" value="P:blood coagulation, intrinsic pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035855">
        <property type="term" value="P:megakaryocyte development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010572">
        <property type="term" value="P:positive regulation of platelet activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052313">
        <property type="entry name" value="GPIb-IX-V_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000372">
        <property type="entry name" value="LRRNT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22650">
        <property type="entry name" value="GLYCOPROTEIN IB BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22650:SF6">
        <property type="entry name" value="PLATELET GLYCOPROTEIN IX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01462">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00013">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0094">Blood coagulation</keyword>
    <keyword evidence="6" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0356">Hemostasis</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033991678" evidence="12">
        <location>
            <begin position="24"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="LRRNT" evidence="13">
        <location>
            <begin position="25"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="LRRCT" evidence="14">
        <location>
            <begin position="92"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="192" mass="21527" checksum="BC364A315B8EF891" modified="2022-01-19" version="1">MNKAEFITAAGFALSLLFHVIQTEVCPPPCNCKPLEEMKGLQIDCSSRKLKEVPALPINTKRLYLQNNSLTTVSPGAFDSVLSLEEIKVSDNPWNCDRHILYLKLWMEDFSESSLANIRCATPAPVRMKPLKQLTGNELGICKRLLPIRSLQFFWRDLVLIGAAIFTLILLGWALKSSKKLVCQIKLTHGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TMP5</accession>
    <name>A0A8C2TMP5_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TMP5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005022393.1">
        <property type="protein sequence ID" value="ENSCJPP00005015842.1"/>
        <property type="gene ID" value="ENSCJPG00005013084.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01070000257305"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="183" mass="19512" checksum="9F23E573A917441E" modified="2022-01-19" version="1">MDGWAGRKAKGWLWGGIDGQQGEQHREHPDAHADKLHPVSLLSGSAGGVDDGQVAVHADASQQQDAAVEVGFLQHRDGFAHDGAKNPLVGPVGSPERQAEGKEQVGHSQVEQVDVGDGAVHVAGGDHQHHQPVAHHAEEEDQAVDEGYEVFVGYRTFITAWGRGDIDVRQNQAVVAIVRSVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TQ20</accession>
    <name>A0A8C2TQ20_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">T cell activation inhibitor, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">TCAIM</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015709474.1">
        <property type="nucleotide sequence ID" value="XM_015853988.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TQ20"/>
    <dbReference type="Ensembl" id="ENSCJPT00005021964.1">
        <property type="protein sequence ID" value="ENSCJPP00005015493.1"/>
        <property type="gene ID" value="ENSCJPG00005012835.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107309301"/>
    <dbReference type="KEGG" id="cjo:107309301"/>
    <dbReference type="CTD" id="285343"/>
    <dbReference type="GeneTree" id="ENSGT00390000012832"/>
    <dbReference type="OrthoDB" id="4238at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028031">
        <property type="entry name" value="DUF4460"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027989">
        <property type="entry name" value="DUF4461"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027986">
        <property type="entry name" value="TCAIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31596">
        <property type="entry name" value="T-CELL ACTIVATION INHIBITOR, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31596:SF1">
        <property type="entry name" value="T-CELL ACTIVATION INHIBITOR, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14687">
        <property type="entry name" value="DUF4460"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14688">
        <property type="entry name" value="DUF4461"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4460" evidence="1">
        <location>
            <begin position="23"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4461" evidence="2">
        <location>
            <begin position="186"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="489" mass="56930" checksum="9910CC870EC24E99" modified="2022-01-19" version="1">MFCCLRVVRRLCLEKILLQCIIQSRTLSGADAIHALKPFYFAVHPDFFGQHPKERAVNENSLKRLNGYLENLQKPGFHSFKPTQLTFYVREREPNSSNVQESFGTSGFRAVSFTLHTRDLLSTVLDILNSCSLSTEHIQSLSVNSQPHKEAKSTLNRPIKWDKTYYSFTGFKDPEEELDQAQRVETTLTSWLDDNEASAVIKLKKSLPLREELERLKFELSHQLQLSDIRWQRSWGIAHRCSQLHSLGRLVQQRPEVLKNVKGRTVVFTDRSGMSAAGHVMLGTMDVHHHWTKIFERLPNYYKLQERLLFLEDRISQLLGGIQVIYVEELQPLLTLEEYYDTLDSFYNKLLDSRLPFHPQSLRGLQMILESDRYTPSLHEFGHFTIPTVCDPATLRWFIIAKAQEARENLKRREEMMITEKELIDSSAEKFSLDRLYKEPSVTSAQMIDCCKRLLQESLPYLQGMHLCISHFYSVLQDGDLCIPWNWKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TQ40</accession>
    <name>A0A8C2TQ40_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vesicle transport protein USE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">USE1-like protein</fullName>
        </alternativeName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the USE1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TQ40"/>
    <dbReference type="Ensembl" id="ENSCJPT00005022694.1">
        <property type="protein sequence ID" value="ENSCJPP00005016103.1"/>
        <property type="gene ID" value="ENSCJPG00005013268.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000014361"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15860">
        <property type="entry name" value="SNARE_USE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019150">
        <property type="entry name" value="Vesicle_transport_protein_Use1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13050">
        <property type="entry name" value="USE1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13050:SF7">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN USE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09753">
        <property type="entry name" value="Use1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="85"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005016103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="146" mass="17057" checksum="DB3AE0A1A70A8B47" modified="2022-01-19" version="1">MFINTLHFLKKYTKVCVYLSTFIICLYLCCVGSLVSDEKQSAVELDAVLQHHQDMQEKLAEEMLSLARSLKNNTLAAQNVIKQDNQTLSHSLRMADQNFEKLKDESDRLEQHAKKSVNWLLWMMLIVVCFIFISMILFIRIFPKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TQQ5</accession>
    <name>A0A8C2TQQ5_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Frizzled-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">FZD3</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Apical cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell surface</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the G-protein coupled receptor Fz/Smo family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015715308.1">
        <property type="nucleotide sequence ID" value="XM_015859822.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015715309.1">
        <property type="nucleotide sequence ID" value="XM_015859823.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015715310.1">
        <property type="nucleotide sequence ID" value="XM_015859824.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TQQ5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005022266.1">
        <property type="protein sequence ID" value="ENSCJPP00005015757.1"/>
        <property type="gene ID" value="ENSCJPG00005013007.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107312409"/>
    <dbReference type="KEGG" id="cjo:107312409"/>
    <dbReference type="CTD" id="7976"/>
    <dbReference type="GeneTree" id="ENSGT00940000156491"/>
    <dbReference type="OrthoDB" id="10053709at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032433">
        <property type="term" value="C:filopodium tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016328">
        <property type="term" value="C:lateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048787">
        <property type="term" value="C:presynaptic active zone membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030165">
        <property type="term" value="F:PDZ domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042813">
        <property type="term" value="F:Wnt receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017147">
        <property type="term" value="F:Wnt-protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033278">
        <property type="term" value="P:cell proliferation in midbrain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071679">
        <property type="term" value="P:commissural neuron axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036514">
        <property type="term" value="P:dopaminergic neuron axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001736">
        <property type="term" value="P:establishment of planar polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042472">
        <property type="term" value="P:inner ear morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097475">
        <property type="term" value="P:motor neuron migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900118">
        <property type="term" value="P:negative regulation of execution phase of apoptosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045976">
        <property type="term" value="P:negative regulation of mitotic cell cycle, embryonic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001843">
        <property type="term" value="P:neural tube closure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002052">
        <property type="term" value="P:positive regulation of neuroblast proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036342">
        <property type="term" value="P:post-anal tail morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036515">
        <property type="term" value="P:serotonergic neuron axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061549">
        <property type="term" value="P:sympathetic ganglion development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060071">
        <property type="term" value="P:Wnt signaling pathway, planar cell polarity pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd15033">
        <property type="entry name" value="7tmF_FZD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07449">
        <property type="entry name" value="CRD_FZ3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000036">
        <property type="entry name" value="frizzled-3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.2000.10:FF:000006">
        <property type="entry name" value="Frizzled-3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2000.10">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015526">
        <property type="entry name" value="Frizzled/SFRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000539">
        <property type="entry name" value="Frizzled/Smoothened_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020067">
        <property type="entry name" value="Frizzled_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036790">
        <property type="entry name" value="Frizzled_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041769">
        <property type="entry name" value="FZ3_CRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309">
        <property type="entry name" value="FRIZZLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309:SF22">
        <property type="entry name" value="FRIZZLED-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01534">
        <property type="entry name" value="Frizzled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01392">
        <property type="entry name" value="Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00489">
        <property type="entry name" value="FRIZZLED"/>
    </dbReference>
    <dbReference type="SMART" id="SM00063">
        <property type="entry name" value="FRI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01330">
        <property type="entry name" value="Frizzled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63501">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50038">
        <property type="entry name" value="FZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="13 18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="14" id="KW-0675">Receptor</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 21" id="KW-0732">Signal</keyword>
    <keyword evidence="16" id="KW-0807">Transducer</keyword>
    <keyword evidence="7 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034629094" description="Frizzled-3" evidence="21">
        <location>
            <begin position="23"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="291"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="370"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="417"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="477"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="FZ" evidence="22">
        <location>
            <begin position="23"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="23">
        <location>
            <begin position="199"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="538"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="550"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="617"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="639"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="28"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="36"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00073182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="666" mass="76169" checksum="AB2B4FF9E42F037B" modified="2022-01-19" version="1">MAVSWMLCCFWLLDVLVGCTRGHSLFSCEPIILRMCQDLPYNTTFMPNLLNHYDQQTAALAMEPFHPMVNLECSRDFRPFLCALYAPVCMEYGRVTLPCRRLCQRAYSECSKLMEMFGVSWPEDMECTRFPDCDEPYPRLVDLSLGGEPTEEAPMAVQRDYGFWCPRELKIDPDLGYSFLRVRDCSPPCPNMYFRREELSFARYFIGVISIVCLSATLFTFLTFLIDVTRFRYPERPIIFYAVCYMMVSLIFFIGFLLEDRVACNASSPAQYKASTVTQGSHNKACTMLFMVLYFFTMAGSVWWVILTITWFLAAVPKWGSEAIEKKALLFHASAWGIPGTLTIVLLAMNKIEGDNISGVCFVGLYDVDALRYFVLAPLCLYVVVGVSLLLAGIISLNRVRIEIPLEKENQDKLVKFMIRIGVFSVLYLVPLLVVIGCYFYEQAYRGVWETTWIQERCREYHIPCPYQVTQMSRPDLILFLMKYLMALVVGIPSVFWVGSKKTCFEWASFFHGRRKKEVVNESRQVLQEPDFAQSLLRDPNTPIIRKSRGTSTQGTSTHASSTQLAMLDDQRSKAGSVHSKVSSYHGSLHRSRDGRYTPCSYRGIEERLPHGSMSRLTDHSRHSSSHRLNEQSRHSSIRDLSSNPLTHITHGTSMNRVIEEDGTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TSS6</accession>
    <name>A0A8C2TSS6_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Programmed cell death 6-interacting protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">PDCD6IP</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Midbody</location>
            <location evidence="1">Midbody ring</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015709659.1">
        <property type="nucleotide sequence ID" value="XM_015854173.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TSS6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005025235.1">
        <property type="protein sequence ID" value="ENSCJPP00005018138.1"/>
        <property type="gene ID" value="ENSCJPG00005014758.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107309390"/>
    <dbReference type="CTD" id="10015"/>
    <dbReference type="GeneTree" id="ENSGT00940000163083"/>
    <dbReference type="OrthoDB" id="2141925at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090543">
        <property type="term" value="C:Flemming body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09240">
        <property type="entry name" value="BRO1_Alix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09235">
        <property type="entry name" value="V_Alix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.280:FF:000001">
        <property type="entry name" value="programmed cell death 6-interacting protein-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.560">
        <property type="entry name" value="alix/aip1 in complex with the ypdl late domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.50">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025304">
        <property type="entry name" value="ALIX_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030">
        <property type="entry name" value="PCD6 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030:SF39">
        <property type="entry name" value="PROGRAMMED CELL DEATH 6-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13949">
        <property type="entry name" value="ALIX_LYPXL_bnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03097">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRO1" evidence="5">
        <location>
            <begin position="3"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="712"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="846"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="551"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="611"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="734"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="754"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="765"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="785"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="798"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="854"/>
            <end position="877"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00074846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005018138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="877" mass="96556" checksum="3A4A7D1A686FCA12" modified="2022-01-19" version="1">MTNFISVQLKKASEVDLAKPLCKFIQQSYPNGDAQAEHCRAAEELSKLRKSALGRPLDKHESALETLLRYYDQLCSIEPKFPFSENQVCVTFTWKDAFDKGSLFGGSVKLALASLGYEKTCVLFNCGALASQIAAEQNLDNDEGLKAAAKHYQFASGAFQHIKDTVLSALSREPTVDISPDTVGTLSLIMLAQAQEVFFLKATRDKMKDGIIAKLANQAADYYGDAYKQCQYKDTLPKEVFPVLAAKHCIMQANAEYHQSILAKQQKKFGEEIGRLQHAADLVKTVASRYDEYINVKDLVDKINRALTAAKKDNDFIYHDRVPDLKDLEPIGKASLVKSTPVAVPLSQKFTDLFEKMVPLQVQQSVSVYNQRKADLVNRLIAQMREATNLANGVLASLNLPAAIEDVSGDTVPQSILNKSKAVIEQGGVQTIDQLIKDLPELLQRNKEILDESLRLLDEEETTDNELRTKFKERWQRTPSNDLYKPLRAEGANFRNILNKAVQADGQVREGYQSHRDTIALLCKPEAELNAAIPSANPAKTLQGSEVVNVLKTLLAGLDEVKKEREQLENDLKSVNFDMTNKFLTALAQDGAINEEAISVTELDRIYGSYTQKVQESLKKQEELLKNIQNAHQDFSKMKQSNNESNLREEVLKNLAVANDNFVELLANLKEGTKFYNELTEILLKFQNKCSDIVFARKTERDELLKDLQQSIAREPSAPSIPLPTYQTTPAGGSKPAASSTPTPAPRTMVGTKPQPPARPPPPVISAASSSPSASAPSGTATAPPSAPAAAPTPPAPGASASSTAPSQAQGPPYPTYPGYPGYCQMPMPIGYNPYMYGQYSLPYAPSPVFQNPGQPPYPAPQQPGYPFPQQPYFPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TSV6</accession>
    <name>A0A8C2TSV6_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="22">Solute carrier family 8 member A3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">SLC8A3</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>Ca(2+)(in) + 3 Na(+)(out) = Ca(2+)(out) + 3 Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:69955"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TSV6"/>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TSY4</accession>
    <name>A0A8C2TSY4_COTJA</name>
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        <submittedName>
            <fullName evidence="3">Coiled-coil-helix-coiled-coil-helix domain containing 1</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="primary">CHCHD1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_015866523.1"/>
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        <property type="protein sequence ID" value="ENSCJPP00005018421.1"/>
        <property type="gene ID" value="ENSCJPG00005015003.1"/>
    </dbReference>
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        <property type="term" value="C:cytosol"/>
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        <property type="term" value="C:fibrillar center"/>
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        <property type="term" value="C:nucleoplasm"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:RNA binding"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:mitochondrial translation"/>
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    </dbReference>
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        <property type="entry name" value="CHCH"/>
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        <property type="entry name" value="Cys_alpha_HP_mot_SF"/>
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        <property type="entry name" value="Ribosomal_mS37_met"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31278">
        <property type="entry name" value="CHCHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31278:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06747">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47072">
        <property type="entry name" value="Cysteine alpha-hairpin motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHCH" evidence="2">
        <location>
            <begin position="51"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005018421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="124" mass="14334" checksum="8C1C26181C267A1A" modified="2022-01-19" version="1">MAAPVYPAWVGRWVSGQWRQRKRPPTVRPIRPLVLADKVANRREMAGEATCLTEMSVMMACWKQNDFNDKACADEIRAFYDCVAMAEKERKEKKDELTLSLKGNIPSSKVNKLLRRFPNTTRYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TUN3</accession>
    <name>A0A8C2TUN3_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TUN3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005024578.1">
        <property type="protein sequence ID" value="ENSCJPP00005017642.1"/>
        <property type="gene ID" value="ENSCJPG00005014376.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00990000203845"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005017642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="58" mass="6611" checksum="6DE12E5209AD177C" modified="2022-01-19" version="1">MIRTPLPRQQKQTHPLHALQRTFLLSCSLVVFPLYKSSKETLGCIISSPLLLPLRLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TV52</accession>
    <name>A0A8C2TV52_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cadherin-12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">CDH12</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Cadherins are calcium-dependent cell adhesion proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Cell membrane</location>
            <topology evidence="1 16">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015709939.1">
        <property type="nucleotide sequence ID" value="XM_015854453.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TV52"/>
    <dbReference type="Ensembl" id="ENSCJPT00005026518.1">
        <property type="protein sequence ID" value="ENSCJPP00005019122.1"/>
        <property type="gene ID" value="ENSCJPG00005015536.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005026519.1">
        <property type="protein sequence ID" value="ENSCJPP00005019123.1"/>
        <property type="gene ID" value="ENSCJPG00005015536.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107309547"/>
    <dbReference type="KEGG" id="cjo:107309547"/>
    <dbReference type="CTD" id="1010"/>
    <dbReference type="GeneTree" id="ENSGT00940000154187"/>
    <dbReference type="OrthoDB" id="6252479at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016342">
        <property type="term" value="C:catenin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034332">
        <property type="term" value="P:adherens junction organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016339">
        <property type="term" value="P:calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044331">
        <property type="term" value="P:cell-cell adhesion mediated by cadherin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007043">
        <property type="term" value="P:cell-cell junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000265">
        <property type="entry name" value="Cadherin 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.900.10:FF:000001">
        <property type="entry name" value="Cadherin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000008">
        <property type="entry name" value="Cadherin 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000009">
        <property type="entry name" value="Cadherin 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000012">
        <property type="entry name" value="Cadherin 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000097">
        <property type="entry name" value="cadherin-12 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.900.10">
        <property type="entry name" value="TCF3-CBD (Catenin binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039808">
        <property type="entry name" value="Cadherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000233">
        <property type="entry name" value="Cadherin_Y-type_LIR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027397">
        <property type="entry name" value="Catenin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027:SF96">
        <property type="entry name" value="CADHERIN-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027">
        <property type="entry name" value="CADHERIN-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01049">
        <property type="entry name" value="CADH_Y-type_LIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 15 16" id="KW-0106">Calcium</keyword>
    <keyword evidence="10 16" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 19" id="KW-0732">Signal</keyword>
    <keyword evidence="5 16 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044679397" description="Cadherin-12" evidence="19">
        <location>
            <begin position="26"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="606"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="20">
        <location>
            <begin position="80"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="20">
        <location>
            <begin position="161"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="20">
        <location>
            <begin position="270"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="20">
        <location>
            <begin position="385"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="20">
        <location>
            <begin position="489"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00069585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU004357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005019123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="794" mass="88478" checksum="CD02CD7792259BFD" modified="2022-01-19" version="1">MLTRNCLSLLLWVLFDGGLLTPLHPQPQQTLEAEPRENVVPVPGRRSSAQRVKRGWVWNQFFVLEEYMGSEPQYVGKLHSDLDKGVGTVKYTLSGDGAGTVFTIDDTTGDIHAIQRLDREEKPFYTLRAQAVDVDTKKPLEPESEFIIKVQDINDNEPKFLDGPYIASVPEMSPVGAYVLQVKATDADDPTYGNSARVVYSILQGQPYFSIDPKTGVIRTALPNMDREVKEQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNDNPPRFPQSIFHLKVPETSHVGSAIGRIRAVDPDFGKNAEIEYNIVPGDGGNLFDITTDENTQEGVIKLKKPLDFETKKAYTFKVEASNLHLDHRFHSVGPFKDTATVKINVLDMDEPPVFSKPLYTMEVYEDTPVGTIIGAVTAQDLDAGSSSVRYFIDWKNDVDSFFTIDANEGTIATNELLDRESTAQYNFSIIASKVSNPLLTSKVNVIINVLDVNEFPPEISVPYETSVCENAKPGQVIQTVTAADKDLSPAGQKFSFRLSPEASNKPNFTVHDYRNNTAGIETRRNGYSRRQQELYFLPVVIEDSSYPVQSSTNTMTIRVCRCDSDGTILSCNVEAIFLPVGLSTGALIAILLCIVILLVIVVLYVALRRQKKKDTLMTSKEDIRDNVIHYDDEGGGEEDTQAFDIGALRNPKVIEDNKMRRDIKPDTLRYPRQRPPVEDNTDIRDFINQRLQENDVDPTAPPYDSLATYAYEGNGSVAESLSSIESLTTEADQDYDYLSDWGPRFKILADMFGEEESYNPDKVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TX23</accession>
    <name>A0A8C2TX23_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DDHD domain containing 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">DDHD2</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PA-PLA1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015738570.1">
        <property type="nucleotide sequence ID" value="XM_015883084.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TX23"/>
    <dbReference type="Ensembl" id="ENSCJPT00005025953.1">
        <property type="protein sequence ID" value="ENSCJPP00005018689.1"/>
        <property type="gene ID" value="ENSCJPG00005015202.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107323734"/>
    <dbReference type="KEGG" id="cjo:107323734"/>
    <dbReference type="CTD" id="23259"/>
    <dbReference type="GeneTree" id="ENSGT00940000156808"/>
    <dbReference type="OrthoDB" id="69269at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034389">
        <property type="term" value="P:lipid droplet organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007626">
        <property type="term" value="P:locomotory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090141">
        <property type="term" value="P:positive regulation of mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008542">
        <property type="term" value="P:visual learning"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000034">
        <property type="entry name" value="ankyrin repeat and SAM domain-containing protein 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004177">
        <property type="entry name" value="DDHD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058055">
        <property type="entry name" value="PA-PLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004170">
        <property type="entry name" value="WWE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057825">
        <property type="entry name" value="WWE_SEC23-DDH2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509">
        <property type="entry name" value="PA-PL1 PHOSPHOLIPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509:SF7">
        <property type="entry name" value="PHOSPHOLIPASE DDHD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02862">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02825">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23464">
        <property type="entry name" value="WWE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01127">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51043">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50918">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WWE" evidence="3">
        <location>
            <begin position="83"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="DDHD" evidence="4">
        <location>
            <begin position="533"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="647"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="661"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005018689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="750" mass="83760" checksum="A3BB7FA74393BC17" modified="2022-01-19" version="1">MGWDGPPRSTAGPPRPEQAQQRAEAAPGAGNGAGSGAEPGSSAVPPRCAAPRAGEQRNRPTSIMSNPEQQPALPSRAAHEAAELDAGNGYEAVVPHWFYCKVTGGRERWLPFSVQDSERLEEAHSAGKDKADVVVPTSGGRYDVHLKQRQCLAVFWEEEVSEVRRCTWFYKGDKDNKYVPYSESFSEELEEAYMVAVTLDEWKKKLESPNREVIILHNPKLMVHYQPVATSDDWGSTPTEQGRPRTVKRGVENIAAEIPNGEPLQIDHLVFVVHGIGPACDIRFRSIVQCVNDFRSVSLSMLQTHFKKAQEQEQIGRVEFLPVNWHSSLHSTGVDVDLERITLPSISRLRHFINDTILDAFFYNSSTYCQTIVDTVASEMNRLYLLFLQRNPDFKGGVSIAGHSLGSLILFDLLTNQKAAPEDEHSREGTEATSSIRGAEEVSEILKKLDLSEYCPAFEKEKIDGEALFLCREKNLEEMGIPLGPRMKLLHYISSRKEMQDTKELSAAGQHSSRDSPYPDVSLGQVSANYPQLLYKPTIFFAFGSPIGMFLTVRGVKRINPDYSLPTCKGFFNIFHPFDPVAYRIEPMIIPDLEFEPMLLPHHKGRKRMHLELKEGLTRMSVDLKNNLLGSLRVAWQSFTRAPLAAVEGASSEGEAETEASAEKQPDPKPEEAPAPSKEDPSLINVGKLNGGNRIDYVLQEKPIESFNEYLFALQGHLCYWESEDTVLLVLKEIYQTIGVTLDQPLPGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TXE3</accession>
    <name>A0A8C2TXE3_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Myocardial zonula adherens protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">MYZAP</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TXE3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005027769.1">
        <property type="protein sequence ID" value="ENSCJPP00005020108.1"/>
        <property type="gene ID" value="ENSCJPG00005016234.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183065"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031674">
        <property type="term" value="C:I band"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051375">
        <property type="entry name" value="Tuftelin_GRINL1A/MYZAP/CCD68"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23171">
        <property type="entry name" value="GDOWN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23171:SF2">
        <property type="entry name" value="MYOCARDIAL ZONULA ADHERENS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="403"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="72"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="167"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="368"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005020108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="442" mass="51553" checksum="FB1C73839F26407F" modified="2022-01-19" version="1">MASACLLLRIVPTQVVTPETEGGSLCCVWLNELYHVPNGVSPGKLSHGMVYGVVHRTDNNHKREMVVYGWSADQLKEEMNYIKEVRATLEKVRKKMYGEYDEMKRKIQQLTNELKVTNAHQESLENHVRVQAAALDSFSEMNSSLTSASIDLQKTLVDVTLENTDIREQIRNLKHTHEQSMEKLREKQKQLETAQIENQLLKLKVESSQEANAEVMREMTRKLYSQYEEKLREEEQKHKAEKEILLEETNRLLKAIEESNKKMQITETSIQEKDQRIGELDRLIERMEEERHQLQKQLELNEIQLSGAKSESNSDSERSQHLEEVAASLRERIKHLDDMVHCQQKKVKHMVEEIEMLRKKVKEKELFIIQLLEKISFLECENKQLQDKLDYLMENQPKANVETRDAGVGCDLPSRSPESTRTTRAYTPFKRVLEYSTKNSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TYR5</accession>
    <name>A0A8C2TYR5_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Potassium voltage-gated channel subfamily A member 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Potassium voltage-gated channel subfamily A member 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">Voltage-gated potassium channel subunit Kv1.2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="24">Voltage-gated potassium channel subunit Kv1.4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="29" type="primary">KCNA4</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="29" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="29" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Axon</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.2/KCNA2 sub-subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.4/KCNA4 sub-subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_032300901.1">
        <property type="nucleotide sequence ID" value="XM_032445010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TYR5"/>
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        <property type="entry name" value="KV14CHANNEL"/>
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    </dbReference>
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    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="20" id="KW-0966">Cell projection</keyword>
    <keyword evidence="19" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="22" id="KW-0407">Ion channel</keyword>
    <keyword evidence="16" id="KW-0406">Ion transport</keyword>
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    <keyword evidence="17 27" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-0564">Palmitate</keyword>
    <keyword evidence="10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-0630">Potassium</keyword>
    <keyword evidence="12" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="9" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 27" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 27" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <keyword evidence="13" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="27">
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            <begin position="325"/>
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            <begin position="70"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="26">
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    <sequence length="662" mass="74060" checksum="01E1B4522C6807AE" modified="2022-01-19" version="1">MEVAMVSADSSGCNSHMPYGYAAQARARERERLAQSRAAAAAAVAAATAAVEGGATGGGGPYHHYHQEQSRGASSSHGGNASRSSLPNRQSGKRWKKGRKRSHHLGSRECGASFPCSELLPLSGSEERILKDVSEEEEEDEDEDEDDEEEGKVYYSADYGEDEFSYSDQPPDDGGGPGGYSSIRYSEYECCERVVINVSGLRFETQLKTLAQFPETLLGDPAKRGRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLKRPVNVPFDIFSEEVKFYQLGEEAMLKFREDEGFVKEEEDKALPENEFQRQVWLLFEYPESSSPARGIAIVSVLVILISIVIFCLETLPEFRDDKEFIMSLSSGKGLSNESLHLDAGEHTIFTDPFFVVETLCIIWFSFELLVRFFACPSKADFLKNIMNIIDIVAIIPYFITLGTELAQEQGSNGQQAMSFAILRIIRLVRVFRIFKLSRHSKGLQILGHTLRASMRELGLLIFFLFIGVILFSSAVYFAEADDPESHFSSIPDAFWWAVVTMTTVGYGDMYPMTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETENEEQTQLMQNAVSCPYLPTNLLKKFRSSSSSSTEDKSEYLEMEEGVKESLCVKEKKSQDTGNSSESEKKNCVNSNSVETDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U068</accession>
    <name>A0A8C2U068_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Epithelial sodium channel subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="24">Amiloride-sensitive sodium channel subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="primary">SCNN1A</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="28" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="28" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="25">This is one of the three pore-forming subunits of the heterotrimeric epithelial sodium channel (ENaC), a critical regulator of sodium balance and fluid homeostasis. ENaC operates in epithelial tissues, where it mediates the electrodiffusion of sodium ions from extracellular fluid through the apical membrane of cells, with water following osmotically.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>Na(+)(in) = Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:34963"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Apical cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Cilium</location>
            <location evidence="2">Flagellum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasmic granule</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Secretory vesicle</location>
            <location evidence="1">Acrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="22">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. SCNN1A subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015728937.1">
        <property type="nucleotide sequence ID" value="XM_015873451.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U068"/>
    <dbReference type="Ensembl" id="ENSCJPT00005028682.1">
        <property type="protein sequence ID" value="ENSCJPP00005020826.1"/>
        <property type="gene ID" value="ENSCJPG00005016713.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107318980"/>
    <dbReference type="KEGG" id="cjo:107318980"/>
    <dbReference type="CTD" id="6337"/>
    <dbReference type="GeneTree" id="ENSGT00940000160952"/>
    <dbReference type="OrthoDB" id="6238402at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001669">
        <property type="term" value="C:acrosomal vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060170">
        <property type="term" value="C:ciliary membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070062">
        <property type="term" value="C:extracellular exosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034706">
        <property type="term" value="C:sodium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050699">
        <property type="term" value="F:WW domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071468">
        <property type="term" value="P:cellular response to acidic pH"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050891">
        <property type="term" value="P:multicellular organismal-level water homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098719">
        <property type="term" value="P:sodium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.470.10:FF:000002">
        <property type="entry name" value="Amiloride-sensitive sodium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.770:FF:000002">
        <property type="entry name" value="Amiloride-sensitive sodium channel subunit beta 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004724">
        <property type="entry name" value="ENaC_chordates"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020903">
        <property type="entry name" value="ENaC_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00859">
        <property type="entry name" value="ENaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF124">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01206">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="18" id="KW-0966">Cell projection</keyword>
    <keyword evidence="14" id="KW-0969">Cilium</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="20" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0282">Flagellum</keyword>
    <keyword evidence="19" id="KW-0407">Ion channel</keyword>
    <keyword evidence="13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="15 27" id="KW-0472">Membrane</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0915">Sodium</keyword>
    <keyword evidence="6" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="17" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="9 27" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 27" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="541"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="582"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00036239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00037944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00050031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00050051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00059503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005020826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="637" mass="73216" checksum="71C82360F961B7A9" modified="2022-01-19" version="1">MGTAPRGGSVKEGKMPAEEKTGQCKQEAEQQQKEDEKEGLIEFYGSYQELFQFFCSNTTIHGAIRLVCSKKNKMKTAFWSVLFFLTFGLMYWQFGILYREYFSYPVNLNLNLNSDRLTFPAVTLCTLNPYRYSAIRKKLDELDQITHQTLLDLYDYNMSLARSDGSAQFSRRRTSRSLLHHVQRHPLRRQKRDNLVSLPENSPSVDKNDWKIGFVLCSENNEDCFHQTYSSGVDAVREWYSFHYINILAQLPDAKDLDESDFENFIYACRFNEATCDKANYTHFHHPLYGNCYTFNDNSSSLWTSSLPGINNGLSLVVRTEQNDFIPLLSTVTGARVMVHDQNEPAFMDDGGFNVRPGIETSISMRKEMTERLGGSYSDCTEDGSDVPVQNLYSSRYTEQVCIRSCFQLNMVQRCSCAYYFYPLPDGAEYCDYTKHVAWGYCYYKLLAEFKADVLGCFHKCRKPCKMTEYQLSAGYSRWPSAVSEDWVFYMLSQQNKYNITSKRNGVAKVNIFFEEWNYKTNGESPAFTVVTLLSQLGNQWSLWFGSSVLSVMELAELILDFIVITFILVFRWCRSKRWHSSPEPPPNSHDNAAFQDEASGLGSPHRFTVEAVVTTLPSYNSLEPCGPSKDGEMGHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U0T6</accession>
    <name>A0A8C2U0T6_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PABIR family member 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">PABIR2</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM122 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2U0T6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005027931.1">
        <property type="protein sequence ID" value="ENSCJPP00005020251.1"/>
        <property type="gene ID" value="ENSCJPG00005016329.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107312736"/>
    <dbReference type="KEGG" id="cjo:107312736"/>
    <dbReference type="CTD" id="159090"/>
    <dbReference type="GeneTree" id="ENSGT00390000015476"/>
    <dbReference type="OrthoDB" id="10036177at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004865">
        <property type="term" value="F:protein serine/threonine phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026716">
        <property type="entry name" value="PBIR1/2/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22227">
        <property type="entry name" value="FAMILY WITH SEQUENCE SIMILARITY 122B ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22227:SF1">
        <property type="entry name" value="PABIR FAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="110"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="121"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="243"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005020251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="284" mass="30788" checksum="FDA79C0FF3315E64" modified="2022-01-19" version="1">MAQEKMELDLELPPGSAAAPSDGGGLRRSNSAPLIHGLSDSSQVFQPYVLRTRRNSTTVTSRHSMLLSSSPIRIPSSRLHQIRREEGVDLMNRETAHEREVQTAMQISQSWEESLSLSDNDLDKSEKSSSPKRIDFIPVSPAPSPTRGIGKQCFSPSLQMFVSSNGLPPSPIPSPTRRFSNRRSQSPINCIRPSVLGPIKRKGEMETESQPKRLFQGTTNMLSPDVTHLTDLSACLSSDILDGSSSSVGSSSDSLTKGSITAESPVTCSNSCSSFILMDDLSPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U0X6</accession>
    <name>A0A8C2U0X6_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycogen synthase kinase-3 beta</fullName>
            <ecNumber evidence="5">2.7.11.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="28" type="primary">GSK3B</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="28" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="28" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12801"/>
            <dbReference type="Rhea" id="RHEA-COMP:13701"/>
            <dbReference type="Rhea" id="RHEA-COMP:13702"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.26"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>L-threonyl-[tau protein] + ATP = O-phospho-L-threonyl-[tau protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53904"/>
            <dbReference type="Rhea" id="RHEA-COMP:13703"/>
            <dbReference type="Rhea" id="RHEA-COMP:13704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.26"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.26" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2U0X6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005029809.1">
        <property type="protein sequence ID" value="ENSCJPP00005021741.1"/>
        <property type="gene ID" value="ENSCJPG00005017366.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00520000055635"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030877">
        <property type="term" value="C:beta-catenin destruction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0002020">
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
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        <property type="entry name" value="GLYCOGEN SYNTHASE KINASE-3 BETA"/>
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        <property type="entry name" value="Pkinase"/>
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    <keyword evidence="19" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="16" id="KW-0221">Differentiation</keyword>
    <keyword evidence="15" id="KW-0418">Kinase</keyword>
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    <keyword evidence="18" id="KW-0524">Neurogenesis</keyword>
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    <evidence type="ECO:0000313" key="29">
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    </evidence>
    <sequence length="469" mass="52377" checksum="3BE910E6680A0E67" modified="2022-01-19" version="1">MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPMIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKDSSGTGHFTSGVRVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGREKPALFNFTTQELSSNPSLASILIPAHARNQAAASTPTNATAASGENARPPACPAPWHHSLWRPRVSRKERTGFSSPAFCSVSAHGHWMLPVVANPHPNLGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U0Y2</accession>
    <name>A0A8C2U0Y2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Rab-like protein 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">GTP-binding protein Parf</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Rab-like protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">RABL6</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">May enhance cellular proliferation. May reduce growth inhibitory activity of CDKN2A.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2U0Y2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005027029.1">
        <property type="protein sequence ID" value="ENSCJPP00005019525.1"/>
        <property type="gene ID" value="ENSCJPG00005015815.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000016002"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000781">
        <property type="entry name" value="RAB, member RAS oncogene family like 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040385">
        <property type="entry name" value="RABL6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14932:SF1">
        <property type="entry name" value="RAB-LIKE PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14932">
        <property type="entry name" value="RAS GTPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08477">
        <property type="entry name" value="Roc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="278"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="291"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="330"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="348"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="415"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="553"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="614"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="624"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="679"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="692"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00074904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00080075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00080258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005019525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="723" mass="79580" checksum="069BA0E7B9ECCFFF" modified="2022-01-19" version="1">MFSALKKLVGSEQAGRDKNIPAGLQSMNQALQRRFAKGVQYNMKIVIRGDRNTGKTTLWHRLQGKKFIEEYIPTQEIQVTSIHWNYKTTDDIVKVEVWDVVDKGKCKKRGDGLKLENDPQEAESEMALDAEFLDVYKNCNGVVMMFDITKQWTFNYILRELPKVPTHVPVCVLGNYRDMGEHRVILPGDVRDFIDNLNRPPGSSYFRYAESSMKNSFGLKYLHKFFNIPFLQLQRETLLRQLETNQLDIDATLEELSVQQETEDQNYELFLEMMEARSRGHASPLTTNGQSPSSGSQSPIVPPSSTSTGSSSPGTPQPPQPPSTSSTISPEPPSSFSPVPAPEAQSPHAPPPAAASPAPPSAALPPKRSIISRLFGTSPAPDPSPPQPDAAAATPPHPAAPAKVQSVEDFVPDDSLDHSFLEDSAPQKDKGKPQTKHRVDSESDGETPGGNPMVAGFQDDLDLDDKIPSRSVLATERVPSKNITLSSEEEEEEEAKDSRVTLIPDESIDTEREKKRSSRNSVKPQSEAVLTKTTDLKPHDSLPPHSGSERNSSSKLGASLSGAAATAAVQAPKTTSQSKGHAHKQKVVKEERPEESDSDQEGPIATQMLSFVMDDPDFESEESDSQRKKMDEFPVREDLSEISDDDTSLAKPPQPVKSTVHSFKLKNDSDLFGLGLEEAGPKESSEEDKHASKEKKKKKKKSKEGGLLELVPSQPQWCTLLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U3I2</accession>
    <name>A0A8C2U3I2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">EGF-containing fibulin-like extracellular matrix protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Fibulin-3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">EFEMP1</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Interacts with ECM1. Interacts with TIMP3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fibulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015712283.1">
        <property type="nucleotide sequence ID" value="XM_015856797.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015712284.1">
        <property type="nucleotide sequence ID" value="XM_015856798.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U3I2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005028427.1">
        <property type="protein sequence ID" value="ENSCJPP00005020606.1"/>
        <property type="gene ID" value="ENSCJPG00005016569.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107310813"/>
    <dbReference type="KEGG" id="cjo:107310813"/>
    <dbReference type="CTD" id="2202"/>
    <dbReference type="GeneTree" id="ENSGT00940000157837"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005006">
        <property type="term" value="F:epidermal growth factor receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005154">
        <property type="term" value="F:epidermal growth factor receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043010">
        <property type="term" value="P:camera-type eye development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048048">
        <property type="term" value="P:embryonic eye morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032331">
        <property type="term" value="P:negative regulation of chondrocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048050">
        <property type="term" value="P:post-embryonic eye morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000323">
        <property type="entry name" value="EGF-containing fibulin-like extracellular matrix protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000418">
        <property type="entry name" value="EGF-containing fibulin-like extracellular matrix protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000201">
        <property type="entry name" value="EGF-containing fibulin-like extracellular matrix protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000240">
        <property type="entry name" value="Vitamin K-dependent protein S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026823">
        <property type="entry name" value="cEGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055088">
        <property type="entry name" value="Fibulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052235">
        <property type="entry name" value="Nephronectin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24050:SF26">
        <property type="entry name" value="FIBULIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24050">
        <property type="entry name" value="PA14 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12662">
        <property type="entry name" value="cEGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22914">
        <property type="entry name" value="Fibulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="10 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 16" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0339">Growth factor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 18" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034870522" description="EGF-containing fibulin-like extracellular matrix protein 1" evidence="18">
        <location>
            <begin position="19"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="19">
        <location>
            <begin position="132"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="19">
        <location>
            <begin position="173"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="19">
        <location>
            <begin position="213"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="19">
        <location>
            <begin position="253"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="85"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="177"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="217"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00054842"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00064427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00072839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00080305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005020606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="451" mass="50702" checksum="42DA587C8F55290F" modified="2022-01-19" version="1">MMLTAMFLAALILITVHSQETEETITYTQCTDGYEWDPVRQRCKDIDECEIVPDACKGGMKCVNHYGGYLCLPRTAQIIVNEREEAAAESTSGRNNVIRRTPADPHRAPPNPTHQIQCASGYEQSEHNVCQDIDECATGTHNCRADQMCVNLRGSFSCQCPPGYQKRGEQCVDIDECTLPPYCHHRCVNTPGSYYCQCNAGFQLASNNHTCVDINECDANNPCAQQCYNILGSFICQCNPGFELSSDRINCEDTDECRTSSYICQYQCVNEPGKFSCVCPEGYQVVGGRTCQDINECETTNECREDEICWNYHGGFRCYPINPCQEPYVLTSENRCVCPVSNTICRELPYSVVYKYMSIRSDRTVPSDIFQIQATTIYPNTINTFRIKSGNENGEFYLRQTSAVSAMLVLVKSLSGPREHIVDLEMLTVNSLNYRTSSVLRLTIIVGPYAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U3X8</accession>
    <name>A0A8C2U3X8_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nuclear transcription factor Y subunit gamma</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">CAAT box DNA-binding protein subunit C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Nuclear transcription factor Y subunit C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">NFYC</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterotrimeric transcription factor composed of three components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC must interact and dimerize for NF-YA association and DNA binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the NFYC/HAP5 subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015738747.1">
        <property type="nucleotide sequence ID" value="XM_015883261.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015738748.1">
        <property type="nucleotide sequence ID" value="XM_015883262.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015738749.1">
        <property type="nucleotide sequence ID" value="XM_015883263.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U3X8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005029638.1">
        <property type="protein sequence ID" value="ENSCJPP00005021593.1"/>
        <property type="gene ID" value="ENSCJPG00005017275.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107323836"/>
    <dbReference type="KEGG" id="cjo:107323836"/>
    <dbReference type="CTD" id="4802"/>
    <dbReference type="GeneTree" id="ENSGT00940000155689"/>
    <dbReference type="OrthoDB" id="1272441at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016602">
        <property type="term" value="C:CCAAT-binding factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032993">
        <property type="term" value="C:protein-DNA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd22908">
        <property type="entry name" value="HFD_NFYC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000006">
        <property type="entry name" value="Nuclear transcription factor Y subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF8">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="13">
        <location>
            <begin position="28"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005021593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="328" mass="36459" checksum="425A642E3090279E" modified="2022-01-19" version="1">MSTDGSFGTGSSSDAQQSLQSFWPRVMEEIRNLTVKDFRVQELPLARIKKIMKLDEDVKMISAEAPVLFAKAAQIFITELTLRAWIHTEDNKRRTLQRNDIAMAITKFDQFDFLIDIVPRDELKPPKRQEEVRQAVTPAEPVQYYFTLAQQPAAVQVQGQQQGQQTTTSTTTIQPGQIIIAQPQQGQVGEGQQVQIVQAQPQGQSQQAQSGTGQTMQVMQQIITNTGEIQQIPVQLNAGQLQYIRLAQPVSGTQVVQGQIQTLATNAQQITQTEVQQGQQQFSQFTDGQQLYQIQQVTMPAGQDIAQPMFIQSTNQSSDGQATQVTGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U4I1</accession>
    <name>A0A8C2U4I1_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutaredoxin and cysteine rich domain containing 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">GRXCR1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015717863.1">
        <property type="nucleotide sequence ID" value="XM_015862377.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U4I1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005029204.1">
        <property type="protein sequence ID" value="ENSCJPP00005021246.1"/>
        <property type="gene ID" value="ENSCJPG00005017008.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107313778"/>
    <dbReference type="KEGG" id="cjo:107313778"/>
    <dbReference type="CTD" id="389207"/>
    <dbReference type="GeneTree" id="ENSGT00940000159219"/>
    <dbReference type="OrthoDB" id="423313at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060091">
        <property type="term" value="C:kinocilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032420">
        <property type="term" value="C:stereocilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060088">
        <property type="term" value="P:auditory receptor cell stereocilium organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070588">
        <property type="term" value="P:calcium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090102">
        <property type="term" value="P:cochlea development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051649">
        <property type="term" value="P:establishment of localization in cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007009">
        <property type="term" value="P:plasma membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905144">
        <property type="term" value="P:response to acetylcholine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051592">
        <property type="term" value="P:response to calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007605">
        <property type="term" value="P:sensory perception of sound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060118">
        <property type="term" value="P:vestibular receptor cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd03031">
        <property type="entry name" value="GRX_GRX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042797">
        <property type="entry name" value="GRXCR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46990">
        <property type="entry name" value="GLUTAREDOXIN DOMAIN-CONTAINING CYSTEINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46990:SF1">
        <property type="entry name" value="GLUTAREDOXIN DOMAIN-CONTAINING CYSTEINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23733">
        <property type="entry name" value="GRXCR1-2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="2">
        <location>
            <begin position="159"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005021246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="310" mass="34612" checksum="9ED9DC9C1A1F56E2" modified="2022-01-19" version="1">MGTTLEQCKLLISVEETMFKGEVKAESERLSRKVRFRVASSHSGRVLKEVYADGEATDSLDSEYTSSSETDQTSRLSEVEGQQNGHGGSECDENENEQDDLLILVRATKEKGFGTKRVNILSKNGTVRGVKHKVSAGQALFDNLSKIFQVSTVPEFGRIVIYTTSLRVVRTTFERCELVRKIFQNHRVKFEEKNIALNSDYGKELDERCRRVCEAPSLPVVFIDGHYLGGAEKILLMNESGELQDLLTKIERVQHPHECLSCGGFGFLPCSVCHGSKMSVFRNCFTDSFKALKCTACNENGLQRCRSCAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U4X0</accession>
    <name>A0A8C2U4X0_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Claudin domain containing 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">CLDND1</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015731224.1">
        <property type="nucleotide sequence ID" value="XM_015875738.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015731232.1">
        <property type="nucleotide sequence ID" value="XM_015875746.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015731240.1">
        <property type="nucleotide sequence ID" value="XM_015875754.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015731248.1">
        <property type="nucleotide sequence ID" value="XM_015875762.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U4X0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005029935.1">
        <property type="protein sequence ID" value="ENSCJPP00005021836.1"/>
        <property type="gene ID" value="ENSCJPG00005017438.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107320146"/>
    <dbReference type="KEGG" id="cjo:107320146"/>
    <dbReference type="CTD" id="56650"/>
    <dbReference type="GeneTree" id="ENSGT00390000002596"/>
    <dbReference type="OrthoDB" id="9885915at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042356">
        <property type="entry name" value="CLDN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004031">
        <property type="entry name" value="PMP22/EMP/MP20/Claudin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14347">
        <property type="entry name" value="CLAUDIN DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14347:SF3">
        <property type="entry name" value="CLAUDIN DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13903">
        <property type="entry name" value="Claudin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005021836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="251" mass="28014" checksum="4F2CCD13FAB86594" modified="2022-01-19" version="1">MMDNRFATALVIACVLSLISTIYMAASLGTDFWYEYHTLSPAENITEAGRSIWEEFVSEEADEKTYTDALFRCNGTVGLWRRCITVPKNSHWYSPPETDMTTNCISFSLSDQFMEKYIEPGNHNSGTDLNRTYLWRLQFLLPFVSLGLMCFGALIGLCACACRSLYPAIATGVLHFLAGLCTLGLVGCYVAGIELLHKKLPLPGDVRGEFGWSFCLACVSAPLQFMAAALFIWAARTNRKEFTLLKAYRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U5B8</accession>
    <name>A0A8C2U5B8_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tropomodulin 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TMOD2</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tropomodulin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2U5B8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005032187.1">
        <property type="protein sequence ID" value="ENSCJPP00005023490.1"/>
        <property type="gene ID" value="ENSCJPG00005018623.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160631"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005865">
        <property type="term" value="C:striated muscle thin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005523">
        <property type="term" value="F:tropomyosin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006936">
        <property type="term" value="P:muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030239">
        <property type="term" value="P:myofibril assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051694">
        <property type="term" value="P:pointed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000006">
        <property type="entry name" value="Tropomodulin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004934">
        <property type="entry name" value="TMOD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10901">
        <property type="entry name" value="TROPOMODULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10901:SF15">
        <property type="entry name" value="TROPOMODULIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03250">
        <property type="entry name" value="Tropomodulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005023490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="366" mass="40787" checksum="8DDD1F741BB2FDBE" modified="2022-01-19" version="1">MSLPFRKELEKYKNINEDEILSKLSEDELKQLEHVLDDLDPENALLPAGFRQKDQTTKPATGPFDRERLLSYLEKQALEHKDREDFVPFTGEKKGKIFIPKEKPIETRTEEKVTLDPELEEALASASDTELYDLAAVLGVHNMVNNPKFDEGGARSKDGKGSVRNVVKGEKVKPIFEEPPNPTNVEASLQRIKANDPTLVEVNLNNIKNIPIPTLKEFAKALESNVHVKTFSLAATRSNDPVAIAFADMLKVNKTLKSLNVESNFITGTGILALIDALKENESLTEIKIDNQRQQLGTAVEMEIAKMLEENSKILKFGYQFTKQGPRTRVAAAITKNNDLGKMLLHSLLICPGEPSPGLYTLPVCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U5K0</accession>
    <name>A0A8C2U5K0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Zinc finger and BTB domain-containing protein 17</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Zinc finger protein 151</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Zinc finger protein Z13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">ZBTB17</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015737759.1">
        <property type="nucleotide sequence ID" value="XM_015882273.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U5K0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005030528.1">
        <property type="protein sequence ID" value="ENSCJPP00005022241.1"/>
        <property type="gene ID" value="ENSCJPG00005017766.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107323317"/>
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        <property type="component" value="Chromosome 21"/>
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        <property type="term" value="C:nucleus"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:protein-DNA complex"/>
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    <dbReference type="GO" id="GO:0001046">
        <property type="term" value="F:core promoter sequence-specific DNA binding"/>
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        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:DNA-binding transcription factor binding"/>
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        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:transcription coactivator binding"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0007398">
        <property type="term" value="P:ectoderm development"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:G1 to G0 transition"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:gastrulation with mouth forming second"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:negative regulation of cell population proliferation"/>
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    </dbReference>
    <dbReference type="CDD" id="cd18206">
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        <property type="entry name" value="Krueppel-related zinc finger protein"/>
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        <property type="entry name" value="ZFP90 zinc finger protein"/>
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    <dbReference type="FunFam" id="3.30.710.10:FF:000048">
        <property type="entry name" value="zinc finger and BTB domain-containing protein 17"/>
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        <property type="entry name" value="zinc finger and BTB domain-containing protein 17 isoform X1"/>
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        <property type="entry name" value="zinc finger and BTB domain-containing protein 17 isoform X1"/>
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    <dbReference type="FunFam" id="3.30.160.60:FF:001032">
        <property type="entry name" value="zinc finger and BTB domain-containing protein 17 isoform X1"/>
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    <dbReference type="FunFam" id="3.30.160.60:FF:000346">
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        <property type="entry name" value="zinc finger protein 143 isoform X1"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00651">
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        <property type="entry name" value="zf-C2H2"/>
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        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="13"/>
    </dbReference>
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        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="9"/>
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    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="13"/>
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    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BTB" evidence="18">
        <location>
            <begin position="24"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="316"/>
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    <feature type="domain" description="C2H2-type" evidence="19">
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    <feature type="domain" description="C2H2-type" evidence="19">
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        </source>
    </evidence>
    <sequence length="817" mass="89333" checksum="C7E1649A43431B23" modified="2022-01-19" version="1">MDFPQHSRQVLEQLNQLRQLGLLCDCTFVVDGINFKAHKAVLAACSEYFRMLFVDQKEDVVHLDISNVAGLGQVLEFMYTAKLSLNPDNVEDVLAVAGILQMREIVNACNALKSLTVLAESPVESRELLTELGAEKGIVEGKAAAEVTQGDSDKPKQVPPSQEGKEEAPVVTAAQPKEPAEQPDAKESPAEGQQPGGADSAAEAGPAATSPSCLQPAESEVGNSSPKEKGSDDPSTEAREMELEGKEEEGEAMAEGEEEAKIAKAAQPKLESRENAEDNESGSTDSGQENSGETRLLRSGTYSDRTESKAYGSVTHKCEDCGKEFTHTGNFKRHIRIHTGEKPFSCRECNKAFSDPAACKAHEKTHSPLKPYGCEECGKSYRLISLLNLHKKRHTGEAKYRCDDCGKLFTTSGNLKRHQLVHSGEKPYQCDYCGRSFSDPTSKMRHLETHDTDKEHKCPHCDKKFNQVGNLKAHLKIHIADGPLKCRECGKQFTTSGNLKRHLRIHSGEKPYVCVHCQRQFADPGALQRHVRIHTGEKPCQCLICGKAFTQASSLIAHVRQHTGEKPYVCERCGKRFVQSSQLANHIRHHDNIRPHKCTVCNKAFVNVGDLSKHIIIHTGEKPFLCDKCGRGFNRVDNLRSHVKTVHQGKAGMKILEPEDGSELNIVTVASDDMVTLATEALAATAVTQLTVVPVAAAVTADETEALKAEITKAVKQVQEADPNTQILYACDSCGEKFLDATSLAQHVRIHTAQALVMFQADTDFYQQYGAAAATWQTEQVIPTTELLFRTRDSPQEAPAAPLAPVPLAGEGQAPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U5V9</accession>
    <name>A0A8C2U5V9_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Protein PALS1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Protein associated with Lin-7 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">PALS1</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Apical cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell junction</location>
            <location evidence="3">Tight junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MAGUK family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2U5V9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005029652.1">
        <property type="protein sequence ID" value="ENSCJPP00005021603.1"/>
        <property type="gene ID" value="ENSCJPG00005017284.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107314973"/>
    <dbReference type="KEGG" id="cjo:107314973"/>
    <dbReference type="CTD" id="64398"/>
    <dbReference type="GeneTree" id="ENSGT00940000156087"/>
    <dbReference type="OrthoDB" id="43580at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043219">
        <property type="term" value="C:lateral loop"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035749">
        <property type="term" value="C:myelin sheath adaxonal region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043220">
        <property type="term" value="C:Schmidt-Lanterman incisure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
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    <sequence length="675" mass="77067" checksum="BDF293B748BBC951" modified="2022-01-19" version="1">MTTSHMNGHITEDSDSEAKNVDLASPEEPQKHREMAVDCPGDLGSRMMPMRRSAQLERIRQQQEDIRRRREEEGKKQELDLTASMRLKKLAQIPPKTGIDNPIFDTEEGIVLESPHYTVKTLEVEELLTSLKHIQHVLVDPQSQEDISLILQLVQNTDFQNAFKIHNAVTVYMNKASPPYPLISNAQELAQEVQCVLKPSHHRDGQELNALLNAPHMQALLLAHDKVAEQEMQPEPVADEKIYENVGTYGGETVKIVRIEKARDIPLGATVRNEMDSVIISRIVKGGAAEKSGLLHEGDEVLEINGIEIRGKDVNEVFDLLADMHGTLTFVLIPSQQSKPPPAKETVIHVKAHFDYDPSDDPYVPCRELGLSFQKGDILHVISQEDPNWWQAYRDGDEDNQPLAGLIPGKSFQQQREAMKQTIEEDKEPEKSGKLWCAKKNKKKRKKVLYNANKNDDYDNEEILTYEEMSLYHQPANRKRPIVLIGPQNCGQNELRQRLMNNEVDRFASAVPHTTRSRRETEVAGRDYHFISRQAFENDIAAGKFIEYGEFEKNLYGTSIDSVRQVINSGKICLLNLHTQSLKTLRNSDLKPYIIFVAPPSQERLRALLAKEGKNPKPEELREIIEKTREMEQNNGHYFDTAIVNSDLDKAYQELLRLINKLDTEPQWVPSTWLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U6X0</accession>
    <name>A0A8C2U6X0_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">PDZ domain containing ring finger 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">PDZRN3</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_015875342.2"/>
    </dbReference>
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        <property type="gene ID" value="ENSCJPG00005018664.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107319948"/>
    <dbReference type="KEGG" id="cjo:107319948"/>
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    <dbReference type="GeneTree" id="ENSGT00950000183062"/>
    <dbReference type="OrthoDB" id="6270329at2759"/>
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        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031594">
        <property type="term" value="C:neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007528">
        <property type="term" value="P:neuromuscular junction development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd06715">
        <property type="entry name" value="PDZ1-PDZRN4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="RING-HC_LNX3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="E3 ubiquitin-protein ligase PDZRN3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051971">
        <property type="entry name" value="E3_ubiquitin-PDZ_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013010">
        <property type="entry name" value="Znf_SIAH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15545:SF5">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PDZRN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15545">
        <property type="entry name" value="PDZ DOMAIN CONTAINING RING FINGER PROTEIN 3, 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PDZ domain-like"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51081">
        <property type="entry name" value="ZF_SIAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="18"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="SIAH-type" evidence="11">
        <location>
            <begin position="76"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="10">
        <location>
            <begin position="247"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="10">
        <location>
            <begin position="418"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="544"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="743"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="805"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="670"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="553"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="563"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="743"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="754"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="820"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="840"/>
            <end position="854"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00455"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005023553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1060" mass="119472" checksum="D12D71BDD2E3BE15" modified="2022-01-19" version="1">MGFELDRFSGEVDPDFKCNLCNKVLEDPLTTPCGHVFCAGCVLPWVVQQGSCPANCQRISAKELNHVLPLKSLILKLDIKCDNHARGCEAVVPLQHLGEHAETCDFSPAKCRNRGCRQVLNLRDVESHMRERCEARPAGLCEQGCGLMLTHGERRSGGHSCLRALRAHGAALQARAAALEKALKKEALRAGKREQSLLSRLAAAQLELQVTALRYQKRFTQYSARLDALARARSASPGKGEETKALTLVLHRDSGSLGFNIIGGRPCVDNQDGSTSEGIFVSKIVDTGPAAKEGGLQIHDRIIEVNGKDLSKATHEQAVEAFKTAKEPIVVQVLRRTPRTKIFTAPESQLVDVGTQTDITFEHIMALSKMGSPTPPVSVLDPYLLPKDHPSVHEYYDPNDYMGGIHQEMDRDELELEEVDLHRVNSQDKLGLTVCYRTDDEDDIGIYVSEIDPNSIAAKDGRLREGDRIIQINGIEVQNREEAVALLSSEESKNISLLVARPEIQLDEGWMDDDRNDFLDDLHMDMLEEQHHQAMQFTASMLQQKKHEEDGGTTDTATILSNQHEKDSGVGRTDDSTRNDESSEQENNADDHTTSTNTLGSQKKLTYSHDTLGSGDMQFSNESFISADCTDVDFLGIPVDECERFRELLELKCQVKSANPYSLYYHTSTLDMSKSDQESVDKELEMLNEELRSIELECLNIVRAHKMQQLKDQYREPWMLHNSGFRNYNTSIDVRRHELSDITELPEKSDKDSSSAYNTGESCRSTPLTLEISPDNSLRRTAEGINCQGNEGAVAYNVSQKNLFSSSESHESSTGKCHSSAKDPETSKQMECKERKASDGSKSPTHGQKPSGSYVSPYHHSPYKHAHIPAHAQHYQSYMQLIQQKSAVEYAQSQMSLVSMCKDFSASQSEPRMEWKVKVRSDGTRYITKRPVRDRLLRERAIKIKEERSGMTTDDDAISEMKMGRYWSKEERKQHLVRAKEQRRRREFMMQSRLDCLKEQQGAEEKKEVNIIELSHKKMMKKRNKKIFDNWMTIQELLTHGTKSPDGTRVYNSFLSVTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U6Z2</accession>
    <name>A0A8C2U6Z2_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">tRNA nucleotidyl transferase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">TRNT1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015730738.1">
        <property type="nucleotide sequence ID" value="XM_015875252.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U6Z2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005032302.1">
        <property type="protein sequence ID" value="ENSCJPP00005023577.1"/>
        <property type="gene ID" value="ENSCJPG00005018681.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107319901"/>
    <dbReference type="KEGG" id="cjo:107319901"/>
    <dbReference type="CTD" id="51095"/>
    <dbReference type="GeneTree" id="ENSGT00390000009678"/>
    <dbReference type="OrthoDB" id="445712at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004810">
        <property type="term" value="F:CCA tRNA nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160016">
        <property type="term" value="F:CCACCA tRNA nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990180">
        <property type="term" value="P:mitochondrial tRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001680">
        <property type="term" value="P:tRNA 3'-terminal CCA addition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106354">
        <property type="term" value="P:tRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd05398">
        <property type="entry name" value="NT_ClassII-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="cca-adding enzyme, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050264">
        <property type="entry name" value="Bact_CCA-adding_enz_type3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032828">
        <property type="entry name" value="PolyA_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46173">
        <property type="entry name" value="CCA TRNA NUCLEOTIDYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46173:SF1">
        <property type="entry name" value="CCA TRNA NUCLEOTIDYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12627">
        <property type="entry name" value="PolyA_pol_RNAbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81891">
        <property type="entry name" value="Poly A polymerase C-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Poly A polymerase head" evidence="10">
        <location>
            <begin position="114"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding" evidence="11">
        <location>
            <begin position="271"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005023577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="488" mass="55323" checksum="8C38D194EFFD3871" modified="2022-01-19" version="1">MMPRIGRHEAPVRSRCGAGGRRGRCRVAPLSSSRCAARSCTELYGAALGLTEAGSPRMWAEVLLLPCRARLLPPLRLRHRAARTMKLQSPQFQALFTPGLRSVAELFEKKNYELRIAGGAVRDLLSGMTPQDVDFATTATPEEMKEMFSSAGVRLINNKGEKHGTITARLHEQNFEITTLRIDIVTDGRHAEVEFTTDWEKDAERRDLTVNSMFLGLDGTLYDFFNGYDDLKNKKIRFVGKASARIQEDYLRILRYFRFYGRIAEKAGDHESDTLQAIKENAKGLAGISGERIWVELKKILIGNHVNHLVRLLYELDVAQYIGLPVNGSLDELDRVSKNTANLCPKPMTVLTSLFKVKDDVTSLDLRLKISKEEKNLGFFLLKHREDLTKATGPEPLKPYQDFIMDSREANTISRILELLKYQGEEQLLKGMQQWTVPTFPVSGHDLRKMGFTCGKEIGSALQQLREEWKKSGYHMDKEELLSCMKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U740</accession>
    <name>A0A8C2U740_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized LOC107321256</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">C1H3orf85</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015733478.1">
        <property type="nucleotide sequence ID" value="XM_015877992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U740"/>
    <dbReference type="Ensembl" id="ENSCJPT00005030299.1">
        <property type="protein sequence ID" value="ENSCJPP00005022083.1"/>
        <property type="gene ID" value="ENSCJPG00005017651.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107321256"/>
    <dbReference type="KEGG" id="cjo:107321256"/>
    <dbReference type="CTD" id="100297006"/>
    <dbReference type="GeneTree" id="ENSGT01150000287305"/>
    <dbReference type="OrthoDB" id="9931701at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034990660" evidence="1">
        <location>
            <begin position="25"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005022083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="120" mass="13691" checksum="864D67593D7990E2" modified="2022-01-19" version="1">MSLKMFQTLVSALLLTVTISGALGIPFLTEESANQFIRLKRQIPYSHSYWDPSSSQNTWGYMVAEQISESWTALKDTAQYYMDLGSYSFDPSIASDNIRSYMDTLQQSGMHLQQQSRMNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U824</accession>
    <name>A0A8C2U824_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Dynein axonemal heavy chain 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Axonemal beta dynein heavy chain 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Ciliary dynein heavy chain 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">DNAH3</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Consists of at least two heavy chains and a number of intermediate and light chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSCJPT00005032490.1">
        <property type="protein sequence ID" value="ENSCJPP00005023761.1"/>
        <property type="gene ID" value="ENSCJPG00005018777.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154959"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.130:FF:000008">
        <property type="entry name" value="Dynein axonemal heavy chain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.30:FF:000002">
        <property type="entry name" value="Dynein axonemal heavy chain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1220:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.710:FF:000004">
        <property type="entry name" value="Dynein axonemal heavy chain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.100:FF:000004">
        <property type="entry name" value="Dynein axonemal heavy chain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002141">
        <property type="entry name" value="Dynein heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.180.20:FF:000003">
        <property type="entry name" value="Dynein heavy chain 12, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2620:FF:000002">
        <property type="entry name" value="Dynein heavy chain 2, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000223">
        <property type="entry name" value="Dynein heavy chain 3, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000063">
        <property type="entry name" value="dynein heavy chain 6, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001328">
        <property type="entry name" value="Dynein heavy chain 6, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.720:FF:000001">
        <property type="entry name" value="dynein heavy chain 7, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.280:FF:000001">
        <property type="entry name" value="dynein heavy chain 7, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.490.20:FF:000001">
        <property type="entry name" value="dynein heavy chain 7, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1120:FF:000005">
        <property type="entry name" value="Dynein, axonemal, heavy chain 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000006">
        <property type="entry name" value="Dynein, axonemal, heavy chain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000362">
        <property type="entry name" value="Dynein, axonemal, heavy chain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:005585">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041589">
        <property type="entry name" value="DNAH3_AAA_lid_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043160">
        <property type="entry name" value="Dynein_C_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878:SF71">
        <property type="entry name" value="DYNEIN, AXONEMAL, HEAVY CHAIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17857">
        <property type="entry name" value="AAA_lid_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0969">Cilium</keyword>
    <keyword evidence="9 18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0243">Dynein</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="19">
        <location>
            <begin position="1304"/>
            <end position="1443"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="19">
        <location>
            <begin position="1943"/>
            <end position="2090"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="702"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="2782"/>
            <end position="2847"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00057074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00071812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00078559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00082097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005023761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="3993" mass="454339" checksum="8370E29B6F327D6A" modified="2022-01-19" version="1">PNRGYPRLLQEASWTLAVPYKEQSYHRSPSDSIANNYSPTAQDLKLKNLHRLMSSSAARTSSASTEGSLLTRPVLCFRSTAGLCSLDPVSLCVAAHGPLGAVCHDQPLTPEEQFVVMLSHEEEMNKREESPSGDDIERYWHYVHNAVREDMLAPQDQEVMNVILKLIPTPILANPCLEKLLVGLKVEVKEDYRISLMKAIVDYILMDPAERQRVLIGSTPRPFPVRVIRAPVPWHSSYKEAKSWNESSLFVVNPLMHTLHQLWLSEFSGVRFVRTADLRAGEMPLPPAVFVDTVRRHCEEAHGLWIPTCASILREERMKWIQFAPGKGCDSPQQIEGYFSSVATLMSLQLRQMVLGSLEDLLRFFMVHEGGSDFAEPYQEMQFFLPQILTVELIVDEPKIIFEPPLKECWDSISLCFREILQSAEELPKVERILFPQLKRDDLTLSTVRPEEPLFAEYIKKLKEIFESNVFGPQRYLNTYRKYNHLLNNSARQDVTDFLNGAPSLEALREKIDSLAELKREIASLRVTVPLALFCLDAAQLHEELCARTQNLQETLIEFEVTENREINKRICGEYNVIANTMSKPPLNTAELVELDAYLKKSSRVTASRLRRDVSEFTHRLQFLMDYADLSDRDIDLNSVVLHWPDRLEEMFDNCRDEQSSRRERAELALQERCSQFDETLEGYDREVESYKKREVMTVDDIMNNTEILKELNKNLDEAVAELEAINKEEELLGKEKSFFPLLQLTITKKQPIEQLWMTAHDFHTKSEEWMHGSLQKLDADEINEEVGNMWRVMYKLSKTFAELPMLKRLAESTKYKLDKFKQHLPVLSLVCNRGMKERHWEQISEVVGREVRLTETTTLENMLELGVSEYTELEPIGAAASKEYSLEKSIEKMKSEWVSVQFGLSKYRDTNHSILSAVDDIQLLLDDHIVKTQTMCGSPFIKPIEAECRAWEAKLNLMQSIIDNWLKCQATWMYLEPIFSSEDIIAQMPEEGRKFGVVDVYWKDIMAQAVKDTRVLVATEQPKMLDRLLEANTLLEDIQKGLNLYLEKKRLFFPRFFFLSNDELLEILSETKDPLRVQPHLKKCFEGIAQLEFTEDLEILGMISSEKEVVPFIDKLYPKNAKGMVEKWLLQVEEMMLASVRQVIQDGIGGYVKVPRKAWVLQWPGQVVICVSTIYWTEAVSEAITKGTLQDFLEESNRQIGDIVDLVRGKLSTGARLTLGALTVIDVHARDVVEKLVEEKITDLNDFQWISQLRYYWEGEDVMVRMITTEAKYGYEYLGNSSRLVITPLTDRCYRTLMGALKLNLGGAPEGPAGTGKTETTKDLAKALAKQCVVFNCSDGLDYKAMGKFFKGLAQSGAWACFDEFNRIEVEVLSVVAQQILSIQQAIVRKVKTFIFEGTEISLNPTCAVFITMNPGYAGRAELPDNLKALFRTVAMMVPDYSLIGEISLYSMGFLDSRSLAQKIVATYRLCSEQLSSQHHYDYGMRAVKSVLTAAGNLKLKYPDENESVLLLRALMDVNLAKFLAQDVPLFQSIISDLFPGVVLPTPDYELFTQALTANIEKMNLQPVPWFVGKIIQVYEMMLVRHGFMIVGEPLGGKTCAYQALAGALGDLNAAKSMDEFAVEYKVINPKAITMGQLYGSFDPVSHEWTDGVLAHAFRAQAASTTEDRKWIVFDGPVDAVWIENMNTVLDDNKKLCLMSGEIIQMSSKMSLIFEAADLEEASPATVSRCGMIYMDPQQLGWKPLKDSYILTLPPNLQEDHRELVNNLFMWLVEPCLDFIHYNCKAVVQTSSLHLTYSFMRLYTCLLDEIKQPEEEGKESMSAQQITLWLQGLFLFALVWTIGGTIDADSRKKFDVFYRNLLLGTEGRPKNVKITRNNIFPEKGTVYDFYFHKRGSGQWSLWTDSITQEEQVIPAGAKVSELIIPTVETARQMFFLKTYVEHDIPLLFVGPTGTGKSAITNSFLLKLPKETYIPVFVNFSARTSANQTQDIIMSKLDRRRKGLFGPPSGKKAVIFVDDLNMPAKEVYGAQPPIELLRQWVDHGHWYDRKDASKIRIVDVLLLSAMGPPGGGRNDITGRFTRHLNIVSICSFEDDILTRIFSAVADWHFSKGFESVFLRLSKMMVQATMTIYKMAVENFLPTPSKSHYVFNLRDFSRVVKGVLLCPHTHLQVSNKLIRLWVHEVYRVFYDRLIDEEDREVFFQMVKQTTTDSFKQDLDKVLGHLSPTGEVTDDHIRSLFFGDYLEPDSSTKAYDEITDLEQLTSVMETYLEEYNNTSRAPMPLVMFKFAIEHISRICRVLKQDNGHLLLVGIGGSGRQSATKLATHMNAFELFQIEITKSYGVNEWKEDVKRVMLRAGVANKNVSFLFCDSQIKDEAFIEDINMLLNTGDVPNIFAADEKADIVEKMQSAARMANEKVEATPLAMYNFFIERMKKSLHIVLAMSPIGDAFRNRLRMFPSLINCCTIDWFQTWPADALEMVANKFLEDVELEDDIRKEVVSMCKYFQETVRELSVSYYSTLRRHNYVTPTSYLELILTFKTLLISKRQEVDTMRNRYLTGLQKLDFASSQVAEMQKELTALQPELIQTSAETEKMMVRIEKETAEVDAKKEIVSADEKEANEAAAAAKAIKDECEGDLAEAMPALEAALAALDTLNPSDISLVKSMQNPPGPVKLVMESICVMKGAKPERKPDPNGSGKMIEDYWGSSRKLLGDLKFLESLKTYDKDHIPPAVMKVIRDRFIDHPDFQPAVIKNVSSACEGLCKWVRAMEVYDRVAKVVAPKRERLKTAEELLDVQMEKLKEKQAELKEVVDRLQALNDDFESMNNRKRDLENNIDLCSQKIVRAEQLISGLGGEKDRWTEAARLLRIRYVDLTGDVLLSSGTVAYLGAFTVDYRLQCQQQWQVLCNEKNIPCSGDFSLSNTLGDPVKIRAWQIAGLPVDSFSIDNGIIVSNSRRWALMIDPQRQANRWVKNMEKANKLSVIKLSDTHYVRTLENAIQLGTPVLLENIGEELDAFIEPILLKLTFKQQGVEYMKLGENILEYSRDFRFYITTRLRNPHYLPEVAVKVCLLNFMITPLGLQDQLLGIVAAEEKPELEEKKNKLIIESAANKKQLKEIEDKILEVLSKSEGNILEDETAINILSSSKTLSEEISEKQKVASATEMQIDSTRVGYKPVAVHSAVVFFCISDLANIEPMYQYSLTWFINLYVQSIAKSKKGEDLEERIENIIEHFTASIYNNVCRSLFEKDKLLFSLLLTVGIMKGRGQIDDEVWRFLLTGGVALDNPHPNPAPDWLSDKSWAELVRASCLTNLQGLMEHVRENFSEWKRIYDSVRPHKENFPDAWNTVTGLDRLVILRCLRPDKIVPAVQQFIVENMGRTFIEPPTFDLGQSYGDSNCCAPLIFVLSPGADPMAGLLKFADDVGMGGANIQTVSLGQGQGPIAANMIHQAVTAGSWVVLQNCHLATSWMPALEKICEEVIVPESTNDKFRLWLTSYPSTEFPVSILQNGIKMTNEPPKGVRANLLRSYLNDPISDATFFNSCQKPEMWQKLLFGLCFFHAVVQERRNFGPLGWNIPYEFNESDLRISMQQIHMFLNEYEEVPFEALTYLTGECNYGGRVTDDKDRRLLLSLLSTVYNKDIEQDKYVLVPGGDYYIPPHGPYESYIEYLRSLPSVTHPEVFGLHENADITKDTQETNQLFSGVLLTLPRVAGGGGRSPQKTVEDLAQDILSKLPSDFDVEEVMRMYPVLYEESMNTVLRQELIRFNRLTQVVRSSLINIGKAIKGLVLMSAELEDVFNSMLMGKVPSMWAAKSYPSLKPLGSYVSDLLCRLSFFQDWVVDGSPTVFWLSGFYFTQSFLTGVLQNYARKYSIPIDHIGFEFEVMKQENTMEKIPEDGAYVRGLFLEGARWDRESAAIGESLPKILYDPLPVIWLKPGESSKFLHLNIYSCPVYKTSARRGVLSTTGHSTNYVLSVELPSKQPQKHWINRGVAALCQLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U8C5</accession>
    <name>A0A8C2U8C5_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">[histone H4]-N-methyl-L-lysine20 N-methyltransferase KMT5B</fullName>
            <ecNumber evidence="3">2.1.1.361</ecNumber>
            <ecNumber evidence="4">2.1.1.362</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">[histone H4]-lysine20 N-methyltransferase KMT5B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">KMT5B</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60344"/>
            <dbReference type="Rhea" id="RHEA-COMP:15554"/>
            <dbReference type="Rhea" id="RHEA-COMP:15555"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="EC" id="2.1.1.361"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:60345"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61992"/>
            <dbReference type="Rhea" id="RHEA-COMP:15556"/>
            <dbReference type="Rhea" id="RHEA-COMP:15998"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:61993"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60348"/>
            <dbReference type="Rhea" id="RHEA-COMP:15555"/>
            <dbReference type="Rhea" id="RHEA-COMP:15556"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
            <dbReference type="EC" id="2.1.1.362"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:60349"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.361" evidence="3"/>
    <dbReference type="EC" id="2.1.1.362" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2U8C5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005031885.1">
        <property type="protein sequence ID" value="ENSCJPP00005023242.1"/>
        <property type="gene ID" value="ENSCJPG00005018467.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156431"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000779">
        <property type="term" value="C:condensed chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036464">
        <property type="term" value="C:cytoplasmic ribonucleoprotein granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001650">
        <property type="term" value="C:fibrillar center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045171">
        <property type="term" value="C:intercellular bridge"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140944">
        <property type="term" value="F:histone H4K20 monomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140941">
        <property type="term" value="F:histone H4K20me methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007517">
        <property type="term" value="P:muscle organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001034">
        <property type="term" value="P:positive regulation of double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045830">
        <property type="term" value="P:positive regulation of isotype switching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd19184">
        <property type="entry name" value="SET_KMT5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1700:FF:000001">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.270.10:FF:000006">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1700">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041938">
        <property type="entry name" value="Hist-Lys_N-MTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044424">
        <property type="entry name" value="KMT5B_SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039977">
        <property type="entry name" value="Suv4-20/Set9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025790">
        <property type="entry name" value="Suv4-20_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12977:SF12">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE KMT5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12977">
        <property type="entry name" value="SUPPRESSOR OF VARIEGATION 4-20-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51570">
        <property type="entry name" value="SAM_MT43_SUVAR420_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0517">Myogenesis</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0678">Repressor</keyword>
    <keyword evidence="10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="15" id="KW-0804">Transcription</keyword>
    <keyword evidence="14" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SET" evidence="23">
        <location>
            <begin position="184"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="353"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="358"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="370"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00031835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005023242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="387" mass="44124" checksum="5673B7E0EC49D522" modified="2022-01-19" version="1">MKWLGESKNMVVNGRRSGSRASNDHVQSQTKLQHTGKENPRSGKNGVERRSSRCSGASGFEGQSRYVPSSGMSAKELCENDDLATSLVLDPYLGFQTHKMNTSFYHYSESDFLLCFRFRPIKGRQEELKEVIERFKKDEHLEKAFKSLTSGDWARHYFLNKNKMQERLFKEHVFIYLRMFATDSGFEILPCNRYSSEQNGAKIVATKEWKRNDKIELLVGCIAELSEMEENMLLRHGENDFSVMYSTRKNCAQLWLGPAAFINHDCRPNCKFVSTGRDTACVKALRDIEPGEEISCYYGDGFFGENNEYCECYTCERRGTGAFKSRVGLPAPTPVINSKYGLRETDKRLNRLKKLGDSSKNSDSQSVSSNTDADTTQEKANQINCFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U905</accession>
    <name>A0A8C2U905_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ring finger protein 113A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">RNF113A</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U905"/>
    <dbReference type="Ensembl" id="ENSCJPT00005033148.1">
        <property type="protein sequence ID" value="ENSCJPP00005024304.1"/>
        <property type="gene ID" value="ENSCJPG00005019175.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000016292"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034247">
        <property type="term" value="P:snoRNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16539">
        <property type="entry name" value="RING-HC_RNF113A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000045">
        <property type="entry name" value="RING finger protein 113A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039971">
        <property type="entry name" value="CWC24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12930:SF0">
        <property type="entry name" value="RING FINGER PROTEIN 113B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12930">
        <property type="entry name" value="ZINC FINGER PROTEIN 183"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="191"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="257"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="191"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="25"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="310"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005024304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="334" mass="38350" checksum="4257F122133E5976" modified="2022-01-19" version="1">VLRRRLKMAEGGSVCGFVFKKRGLAAGRGRRKRPSSDQEQGSSGDEGSTVVRKERRRDAPNPMIQKTRRCTKERPSYALSSSDDDDPSKEIGVTYKSTRSAKPVGPEDMGATAVYELDTEKDKDAQAIFERSQKIQEELRGKEDDKIYRGINNYQKYVKPKDTSMGNASSGMVRKGPIRAPEHLRATVRWDYQPDICKDYKETGFCGFGDSCKFLHDRSDYKHGWQIERELDEGRYGVNDEENYEVSSDEEDMPFKCFICRSSFKNPVVTKCRHYFCESCALQHYRKSQRCYVCDKQTNGVFNPAKELMAKLEKHKGEEEEEESDHSEHGEDPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U906</accession>
    <name>A0A8C2U906_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Eukaryotic translation initiation factor 4E family member 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">EIF4E3</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015730903.1">
        <property type="nucleotide sequence ID" value="XM_015875417.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U906"/>
    <dbReference type="Ensembl" id="ENSCJPT00005032247.1">
        <property type="protein sequence ID" value="ENSCJPP00005023542.1"/>
        <property type="gene ID" value="ENSCJPG00005018652.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107319989"/>
    <dbReference type="KEGG" id="cjo:107319989"/>
    <dbReference type="CTD" id="317649"/>
    <dbReference type="GeneTree" id="ENSGT00940000155865"/>
    <dbReference type="OrthoDB" id="17977at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.760.10:FF:000007">
        <property type="entry name" value="Eukaryotic translation initiation factor 4E family member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF66">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E TYPE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0810">Translation regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005023542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="203" mass="22821" checksum="E670A43D04256464" modified="2022-01-19" version="1">MELSALGPQPARSRSGAEEGAEAPELPLHSAWTFWLDKSLPGTTAAECASNLKKIYRVQTVQDFWSVYNNIPPVTSLPLRCSYHLMRGERRPLWEEESNARGGIWKMKVAKESTAAVWKELLLATVGEQFTDCCAADDEVIGVSISVRDREDVVQVWNGNASLASEAKVLEKIHKLLPHTSFRAVFYKPHREHHAFEGQRGRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U9D5</accession>
    <name>A0A8C2U9D5_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cyclin-F</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">CCNF</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclin family. Cyclin AB subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015732894.1">
        <property type="nucleotide sequence ID" value="XM_015877408.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U9D5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005031871.1">
        <property type="protein sequence ID" value="ENSCJPP00005023228.1"/>
        <property type="gene ID" value="ENSCJPG00005018459.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107320976"/>
    <dbReference type="KEGG" id="cjo:107320976"/>
    <dbReference type="CTD" id="899"/>
    <dbReference type="GeneTree" id="ENSGT00810000125541"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010826">
        <property type="term" value="P:negative regulation of centrosome duplication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd20521">
        <property type="entry name" value="CYCLIN_CCNF_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20522">
        <property type="entry name" value="CYCLIN_CCNF_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22082">
        <property type="entry name" value="F-box_FBXO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000038">
        <property type="entry name" value="Cyclin F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000055">
        <property type="entry name" value="Cyclin F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="10 14" id="KW-0195">Cyclin</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="16">
        <location>
            <begin position="28"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="567"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="614"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="651"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="573"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="585"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="689"/>
            <end position="712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019493"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005023228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="782" mass="87871" checksum="C401564F56118669" modified="2022-01-19" version="1">MKAGVVHCRCSRCFSFPSKRKIRKRPRVLTLLSLPEDVLLHVLKDLPTEDILLLRAVHSHLKYLVDHHAGVWACASFEDVWPSPKNLTVFERAAERGNFEAAVKLGIAYLYNEGLSISDEGRAEVNGLKASHFFSLAERLNVCAAPFIWLFIRPPWSLTGSCCKAVVFESLKAECQLDKAQKGSILYCLAKVLSLFEDEEKRKESLGMFEESSKQGCLNSSYLLWENNRKAAMLDPGRYLQSLRKLRDYAAKGCWDAQIALAKACGNGNQLGLEAKSSSEMVAQMFQASRPISKRNIFTVQKKINETMRYILVDWLVEVATMKDFSCLCLHMTVGCVDRYLKLRPVPRYQLQLLGIACMVICTRFISKEILTIREAVWLTDNTYKYEDLVRMMGEIISALEGKIRIPTIVDYKEVLSNIVSLERRTLHLYSFICELSLLYTSLFMYSPARLAAAALLLAKILHGHAHPWSSQLSECTGFSLEDLLPCVLHLHQKCFHDEVPKDYRQVSLTAVRQRFEDERYDEVGKEKVMSYSQLCSLLGVKQEDLKPSPLHTNVIEIKAFFSSPSAKRSKRRREDSTQDDRGSLVTTPTAELSTQEESLLDSFLDWSLDSCSGYEGDQESEGERDGDVTSPSGILDVTVVYMDPAQHCCQDSSDEDSLSVEWSGHAAPPRKARTPDETRRVSACVASRNPSWERSSGYSSVNGASPTSSVEGSCGVPLKPTSALSHGSALNKEPCLPHYLQSHLQSVCARASDRNSDRRQVKRKNVAEHSEERVNLGFLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U9W0</accession>
    <name>A0A8C2U9W0_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Muscleblind like splicing regulator 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">MBNL2</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the muscleblind family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015707042.1">
        <property type="nucleotide sequence ID" value="XM_015851556.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U9W0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005033546.1">
        <property type="protein sequence ID" value="ENSCJPP00005024645.1"/>
        <property type="gene ID" value="ENSCJPG00005019402.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107308014"/>
    <dbReference type="KEGG" id="cjo:107308014"/>
    <dbReference type="CTD" id="10150"/>
    <dbReference type="GeneTree" id="ENSGT00950000182897"/>
    <dbReference type="OrthoDB" id="6285980at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.210:FF:000004">
        <property type="entry name" value="Muscleblind like splicing regulator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.210:FF:000002">
        <property type="entry name" value="Muscleblind-like 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.210">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054429">
        <property type="entry name" value="Znf-CCCH_Muscleblind-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12675">
        <property type="entry name" value="MUSCLEBLIND-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12675:SF4">
        <property type="entry name" value="MUSCLEBLIND-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22628">
        <property type="entry name" value="zf-CCCH_10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="14">
        <location>
            <begin position="13"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="14">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="14">
        <location>
            <begin position="176"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="14">
        <location>
            <begin position="212"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="13">
        <location>
            <begin position="13"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="13">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="13">
        <location>
            <begin position="176"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="13">
        <location>
            <begin position="212"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005024645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="385" mass="41326" checksum="516377EFD3CE5B69" modified="2022-01-19" version="1">MALNVAPVRDTKWLTLEVCRQFQRGTCSRSDEECKFAHPPKSCQVENGRVIACFDSLKGRCTRENCKYLHPPTHLKTQLEINGRNNLIQQKTAAAMFAQQMQFMLPGTQLQPVPTFPVGPTIGTNTAISFAPYLTPVTPGVGLVPTEILPTPPVIVPGSPPVSVPGSTATQKLLRTDKLEVCREFQRGNCARGETDCRFAHPADSTMIDTNDNTVTVCMDYIKGRCMREKCKYFHPPAHLQAKIKAAQHQANQAAVAAQAAAAAATVMTQSTAKAMKRPLEATVDLAFPPGVLHPLPKRQALEKSNGASAVFNPSVLHYQQALANAQLQQHAAFIPTGSVLCMTPATSIVPMMHGATPATVSAATTPATSVPFAATATANQVCSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UAP9</accession>
    <name>A0A8C2UAP9_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP-dependent RNA helicase DDX42</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">DEAD box protein 42</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">DDX42</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the DEAD box helicase family. DDX42 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2UAP9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005033253.1">
        <property type="protein sequence ID" value="ENSCJPP00005024391.1"/>
        <property type="gene ID" value="ENSCJPG00005019182.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156559"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903241">
        <property type="term" value="P:U2-type prespliceosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd17952">
        <property type="entry name" value="DEADc_DDX42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000524">
        <property type="entry name" value="ATP-dependent RNA helicase DDX42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000079">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="20">
        <location>
            <begin position="253"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="284"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="487"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="654"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="723"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="792"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="16">
        <location>
            <begin position="253"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="70"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="723"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="738"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="17">
        <location>
            <begin position="811"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="822"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="898"/>
            <end position="923"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00061633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00068282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00075438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005024391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="941" mass="103005" checksum="8ED3375A1F74BA56" modified="2022-01-19" version="1">MNWNKGGPGTKRGFGFGGFAITPGKKEEPKLSQQSHSAFGTAGSSAAFAKSGPPQLPSFYKIGSKRANFDEENAYFEDEEEDNSNVDLPYIPAENSPTRQQFNSKSADSDSDDDPLEAFMAEVEDQAARDMKRLEDKDKEKKNAKGIRDDIEEEDDQEAYFRYMAENPTAGVVQEEEEDNLEYDSDGNPIAPSKKIIDPLPPIDHSEIEYPPFEKNFYDEHEEITSLTPQQVVELRHKLNLRVSGAAPPRPGSSFAHFGFDEQLMHQIRKSEYTQPTPIQCQGVPVAMSGRDMIGIAKTGSGKTAAFIWPMLIHIMDQKELEPGDGPIAVIVCPTRELCQQIHSECKRFGKAYNLRSVAVYGGGSMWEQAKALQEGAEIVVCTPGRLIDHVKKKATNLQRVTYLVFDEADRMFDMGFEYQVRSIASHVRPDRQTLLFSATFRKKIEKLARDILIDPIRVVQGDIGEANEDVTQIVEIFPSGPSKWNWLTRRLVEFTSSGSVLLFVTKKANAEELANNLKQEDHNLGLLHGDMDQSERNKVISEFKKKGIPILVATDVAARGLDIPSIKTVINYDVARDIDTHTHRIGRTGRAGEKGVAYTLLTPKDSNFAGDLVRNLEGANQHVSKELLDLAMQNPWFRKSRFKGGKGKKLNIGGGGLGYRERPGLGSESSDRGNNNNVMSNYEAYKPSSGAMGDRLTAMKAAFQSQYKSHFVAASLNNQKTGSSAAGASGWTSAGSLNSVPTSSAQQNAANPDSPIAATAAAKGVPGFTSTGTLSSVPTFPSVGVQGYSNNSANASAGNREGMGSAGSTPRGGSGGGGGVVRERYNDSRNSRHNEVPRRGEGGGRYNDMQHHGEGGGRYSDAYRHGEGRHGDSHRHAESRHFTDTGGGNRNNVDSRNMSEGRSNESRNGENRKDANSRDNKTDGFAVPEPPKRKKSRWDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UAR3</accession>
    <name>A0A8C2UAR3_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DENN domain-containing protein 11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Protein LCHN</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">DENND11</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DENND11 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015722193.1">
        <property type="nucleotide sequence ID" value="XM_015866707.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UAR3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005035200.1">
        <property type="protein sequence ID" value="ENSCJPP00005025932.1"/>
        <property type="gene ID" value="ENSCJPG00005020264.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107315853"/>
    <dbReference type="KEGG" id="cjo:107315853"/>
    <dbReference type="CTD" id="57189"/>
    <dbReference type="GeneTree" id="ENSGT00590000083189"/>
    <dbReference type="OrthoDB" id="2152680at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051731">
        <property type="entry name" value="DENND11/AVL9_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018626">
        <property type="entry name" value="LCHN/Anr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31017:SF2">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31017">
        <property type="entry name" value="LATE SECRETORY PATHWAY PROTEIN AVL9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09804">
        <property type="entry name" value="DENND11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="5">
        <location>
            <begin position="1"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005025932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="445" mass="50420" checksum="64F650317B462DA5" modified="2022-01-19" version="1">MVERADEAPLLFWAEGPAVSAPPPAVEAGGVGGRRLGGGWSAAPWGCEEEEEEAAGPPRTEAEEDQIVAVFVVTFDPRTGNMVEWCLPQDIDLEGVEFKSMASGSHKIQSDFIYFRKGLCFGLACFANMPVESELERGARMKSVGILSPSYTLLYRYMHFLENQVRHQLEMPGHYSHLEAFYDDKKGVLPDNKGTTTSQQPVHWLPSIHRYMYPEMKITHPAGCMSQFIKFFGEQILVLWKFALLRKRILIFSPPPVGVVCYRVYCCCCLANVSLPGLGGTVPESKPFFYVNVADIEMLETEVSYVACTTEKIFEEKRDLYDVYVDNQNVKTHHEHLQPLLKINSADKEKYRRLNDQRQMLMYSQEVGEDCSSCEEDLFILFFMEQNNRIFQTLMEVSASQDKTLTADHARGMGLDPQGDRSFLMDLLEVYGIDVMLVIDNPCCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UCK8</accession>
    <name>A0A8C2UCK8_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Small integral membrane protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">SMIM5</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015735213.1">
        <property type="nucleotide sequence ID" value="XM_015879727.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015735214.1">
        <property type="nucleotide sequence ID" value="XM_015879728.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UCK8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005036398.1">
        <property type="protein sequence ID" value="ENSCJPP00005026869.1"/>
        <property type="gene ID" value="ENSCJPG00005020876.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107322093"/>
    <dbReference type="KEGG" id="cjo:107322093"/>
    <dbReference type="CTD" id="643008"/>
    <dbReference type="GeneTree" id="ENSGT00520000062027"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd20254">
        <property type="entry name" value="CASIMO1_SMIM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047133">
        <property type="entry name" value="SMIM5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031671">
        <property type="entry name" value="SMIM5/18/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37344">
        <property type="entry name" value="SMALL INTEGRAL MEMBRANE PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37344:SF1">
        <property type="entry name" value="SMALL INTEGRAL MEMBRANE PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15831">
        <property type="entry name" value="SMIM5_18_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005026869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="82" mass="9227" checksum="E10F2C454ED10712" modified="2022-01-19" version="1">MSSEVFLKEMQTIGEKLLLKLQKLPKADPVEIVSFCVVLLFIVTVLVLMIIACSCCCYSCCSFNEGPDHRRRKAQVRPTAHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UD69</accession>
    <name>A0A8C2UD69_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Vesicle-trafficking protein SEC22a</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">SEC22 vesicle-trafficking protein homolog A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">SEC22A</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in vesicle transport between the ER and the Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the synaptobrevin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015724265.1">
        <property type="nucleotide sequence ID" value="XM_015868779.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015724266.1">
        <property type="nucleotide sequence ID" value="XM_015868780.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UD69"/>
    <dbReference type="Ensembl" id="ENSCJPT00005036760.1">
        <property type="protein sequence ID" value="ENSCJPP00005027145.1"/>
        <property type="gene ID" value="ENSCJPG00005021071.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107316828"/>
    <dbReference type="KEGG" id="cjo:107316828"/>
    <dbReference type="CTD" id="26984"/>
    <dbReference type="GeneTree" id="ENSGT00940000158470"/>
    <dbReference type="OrthoDB" id="1719357at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.50:FF:000010">
        <property type="entry name" value="vesicle-trafficking protein SEC22a isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059071">
        <property type="entry name" value="SEC22a-c_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043546">
        <property type="entry name" value="Sec22a/c"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46258">
        <property type="entry name" value="LONGIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46258:SF3">
        <property type="entry name" value="VESICLE-TRAFFICKING PROTEIN SEC22A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25970">
        <property type="entry name" value="SEC22a_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Longin" evidence="17">
        <location>
            <begin position="8"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00074407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00081731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005027145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="308" mass="35192" checksum="1EA02CF904D2A05F" modified="2022-01-19" version="1">MSMILSASVVRVRDGLPLSASTDYDQSTGVQECRKYFKMLSKKLSQLPDRCTLKTGQYNINFISSLGVSYMMLCTENYPSVLAFCFLDELQKEFITTYNMMKTNTAVRPYCFIEFDNFIQRTKQRYNNTRSLSTKMNLADMQTEIKLRPPYQISLSELDSANGFAHLSAAEYRGTGKISAAPHQRLDPVTLPGIVSFVLSLLCGALNLIRGFHAIESLLQNEGEDFSYVIAFFLGTAACLYQCYLFVYYTGWRNAKSFLTFGLICLCNMYLYELRNLWQLFFHVTVGAFSTLQIRLRRPQGKSPDYNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UDL4</accession>
    <name>A0A8C2UDL4_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Regulator of G-protein signaling 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">RGS2</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. It is involved in the negative regulation of the angiotensin-activated signaling pathway. Plays a role in the regulation of blood pressure in response to signaling via G protein-coupled receptors and GNAQ. Plays a role in regulating the constriction and relaxation of vascular smooth muscle. Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Interacts with GNAQ. Does not interact with GNAI1 and GNAI3. Interacts with EIF2B5. Interacts with PRKG1 (isoform alpha).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015725019.1">
        <property type="nucleotide sequence ID" value="XM_015869533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UDL4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005036978.1">
        <property type="protein sequence ID" value="ENSCJPP00005027337.1"/>
        <property type="gene ID" value="ENSCJPG00005021206.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107317180"/>
    <dbReference type="KEGG" id="cjo:107317180"/>
    <dbReference type="CTD" id="5997"/>
    <dbReference type="GeneTree" id="ENSGT00940000157937"/>
    <dbReference type="OrthoDB" id="196547at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010855">
        <property type="term" value="F:adenylate cyclase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001965">
        <property type="term" value="F:G-protein alpha-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010614">
        <property type="term" value="P:negative regulation of cardiac muscle hypertrophy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045744">
        <property type="term" value="P:negative regulation of G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046329">
        <property type="term" value="P:negative regulation of JNK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060452">
        <property type="term" value="P:positive regulation of cardiac muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900738">
        <property type="term" value="P:positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071877">
        <property type="term" value="P:regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055119">
        <property type="term" value="P:relaxation of cardiac muscle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060087">
        <property type="term" value="P:relaxation of vascular associated smooth muscle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd08709">
        <property type="entry name" value="RGS_RGS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.167.10:FF:000001">
        <property type="entry name" value="Putative regulator of g-protein signaling 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.196.10:FF:000001">
        <property type="entry name" value="Regulator of G-protein signaling 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.196.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034947">
        <property type="entry name" value="RGS2_RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024066">
        <property type="entry name" value="RGS_subdom1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845:SF43">
        <property type="entry name" value="REGULATOR OF G-PROTEIN SIGNALING 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01301">
        <property type="entry name" value="RGSPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0734">Signal transduction inhibitor</keyword>
    <keyword evidence="10" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="RGS" evidence="16">
        <location>
            <begin position="85"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00046536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005027337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="213" mass="24896" checksum="1D196EE8228FEA96" modified="2022-01-19" version="1">MQSAVFVALPQDGGRMERGSRRRAELEETDKGRMMKRTIIKDWKKKLSYFLQNSSRSGKMKSNKASKHHTYFRPSPEEARLWSEAFDELLANKYGVAAFRAFLKSEFCEENIEFWLACEDFKKTKSPQKLTLKAKKIYNDFIEKEAPKEINIDFQTKNMIAQNLQEATHTCFSAAQKRVYSLMENNSYPRFLESEFYQELCKKPPITRAAQGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UEL1</accession>
    <name>A0A8C2UEL1_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Nuclear receptor subfamily 2 group F member 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">NR2F2</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nuclear hormone receptor family. NR2 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015728620.1">
        <property type="nucleotide sequence ID" value="XM_015873134.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UEL1"/>
    <dbReference type="SMR" id="A0A8C2UEL1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005035932.1">
        <property type="protein sequence ID" value="ENSCJPP00005026519.1"/>
        <property type="gene ID" value="ENSCJPG00005020621.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107318845"/>
    <dbReference type="KEGG" id="cjo:107318845"/>
    <dbReference type="CTD" id="7026"/>
    <dbReference type="GeneTree" id="ENSGT00940000157540"/>
    <dbReference type="OrthoDB" id="5873264at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004879">
        <property type="term" value="F:nuclear receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001972">
        <property type="term" value="F:retinoic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009952">
        <property type="term" value="P:anterior/posterior pattern specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="NR_DBD_COUP_TF"/>
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        <property type="entry name" value="Coup transcription factor 2 isoform 1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Nuclear receptor subfamily 2 group F member 1"/>
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        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
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        <property type="entry name" value="NHR-like_dom_sf"/>
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        <property type="entry name" value="Znf_hrmn_rcpt"/>
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        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
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        <property type="entry name" value="ZnF_C4"/>
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        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
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    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="13">
        <location>
            <begin position="72"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="14">
        <location>
            <begin position="173"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
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            <begin position="52"/>
            <end position="68"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00006421"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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        </source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
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        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
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        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005026519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="410" mass="45427" checksum="760A996E29082E3D" modified="2022-01-19" version="1">MAMVVGAWRDPQDDVPGAQGTQPAPAPPVQGPPAGTPHTPQTPGPGGPPSTPAQSNAASQQSQGDKQQQQQHIECVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLSYTCRANRNCPIDQHHRNQCQYCRLKKCLKVGMRREAVQRGRMPPTQPTHGQFALTNGDPLNCHSYLSGYISLLLRAEPYPTSRFGSQCMQPNNIMGIENICELAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWSELFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTSDACGLSDVAHVESLQEKSQCALEEYVRSQYPNQPTRFGKLLLRLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDMLLSGSSFNWPYMSIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UF50</accession>
    <name>A0A8C2UF50_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dolichol kinase</fullName>
            <ecNumber evidence="3">2.7.1.108</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">DOLK</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the polyprenol kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.108" evidence="3"/>
    <dbReference type="RefSeq" id="XP_015734444.1">
        <property type="nucleotide sequence ID" value="XM_015878958.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UF50"/>
    <dbReference type="Ensembl" id="ENSCJPT00005035281.1">
        <property type="protein sequence ID" value="ENSCJPP00005026004.1"/>
        <property type="gene ID" value="ENSCJPG00005020310.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107321749"/>
    <dbReference type="KEGG" id="cjo:107321749"/>
    <dbReference type="CTD" id="22845"/>
    <dbReference type="GeneTree" id="ENSGT00390000004067"/>
    <dbReference type="OrthoDB" id="377083at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004168">
        <property type="term" value="F:dolichol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180047">
        <property type="term" value="P:dolichol phosphate mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043048">
        <property type="term" value="P:dolichyl monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032974">
        <property type="entry name" value="Polypren_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13205:SF15">
        <property type="entry name" value="DOLICHOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13205">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
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            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="426"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005026004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="515" mass="57476" checksum="8763DC2F25CA507A" modified="2022-01-19" version="1">MLNKPVLVESLIVFSIVLCVHAVVWDRYSWCAVALAIQAFYVQFKWDRLLQQGGAVFQFRTTANSGLLPASMVIPLLGIAMKERCEAAGIVYFERFGIVVASTGMLVALFLSVIAVGITKPVPTNTCILTGVAGSIIIYTMKHSLTVSEVIEVLEVLLIFVYLSMILLYLLPRCFTPGEALLVLGGISFVLNQLIKRSLNVIEGRGEPIDFFLLVAVIGVIILGLFFTVLFIFMDSGTWISSMFFHMMTAVLGLGVIMPWLYRLIRRNPLFWLLQFLFQTQTRVYLLVYWTFLAASACGIVFYQNAKRSSESKKHQASTITRKYFHFIVVATYVPGLIYDLQLLHVAAVLCLAVFIFLEYIRYFRIKPFGQTLRYLLSLFLDERDSGPLILTHIYLLLGMSLPVWLFPRSCAPKGALSGAGALVPYAGVLAVGVGDTMASVFGSTMGEIKWPGTKKTFEGTMTAIFILIFDSNVNLNSSYAWILVSVSLVSLLEAYTTQIDNLLLPLYLQIMFMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UFI5</accession>
    <name>A0A8C2UFI5_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CDKN1A interacting zinc finger protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">CIZ1</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2UFI5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005034823.1">
        <property type="protein sequence ID" value="ENSCJPP00005025613.1"/>
        <property type="gene ID" value="ENSCJPG00005020095.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00440000039084"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051457">
        <property type="term" value="P:maintenance of protein location in nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032298">
        <property type="term" value="P:positive regulation of DNA-templated DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026811">
        <property type="entry name" value="CIZ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056345">
        <property type="entry name" value="Znf-C2H2_CIZ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15491">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15491:SF9">
        <property type="entry name" value="CIP1-INTERACTING ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23330">
        <property type="entry name" value="zf-C2H2_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="7">
        <location>
            <begin position="485"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="114"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="376"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="530"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="618"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="125"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="205"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005025613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="711" mass="78321" checksum="61FEED7E2FB982D4" modified="2022-01-19" version="1">MSNTLFSSGLPPPPPPQQQQMLSLRATNQPSLLNANPMLQRALLMQQMQGNLRGFNMTAPALQQFFPQATRHSLLGPPPVGVSLKPTRMGFPNLPFQRQNRMFRKDFQRLPDRKRELDAGSSSHMHGDEFRGELRAGSEQNNSLLTEPRTPAESVLNTEPAAKRLKSVTEESALENAAGSKEELSTHVQADGTNNVKQYAAESLSKERKFSEEPKAPEVLSSGGSLKVTIQQSSESRAISTTALKPGQWTCEMGTADPSPESALKFYCYICKTNCCNQQNFQAHMAGIQHQQRLGEIQHMSNVCFVSLLPMVKEQKLLAEKDGESQQRWCNTCQIHFTGDLIKHRRTQEHKLAKRSLRPFCTVCSRHFKTPRKFVEHMKSPEHKQKAKEVRLGEKELGSPEDSEELITVDAVGCFEDDEEEEEEEEEEEGTGEGEDLDVVLVENEDSAAKQTGLKEVSLEDYKGSEKYCPDTAYGLDFLVPVAGYLCRLCHKFYHSDSAARLAHCKSLMHFENFQRYKVARHRAAAACPEAPLHSQSSSSQLLDDQEQPPAPSEDTGKKMNVNHGIDKEGTELSALQEQALRSPEGKGKLATSVAESKSLASMTDVCGIVAVEESLQESKSTASCPLPEESSGMGELLGHAVYEEEEEANAARQGEGTDYCQDPGSGGELGQKEASHGGQEAAAEPSSLAKGETASLTSAACRRSSRRKPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UFM9</accession>
    <name>A0A8C2UFM9_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ELL associated factor 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">EAF2</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EAF family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015724263.1">
        <property type="nucleotide sequence ID" value="XM_015868777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UFM9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005036885.1">
        <property type="protein sequence ID" value="ENSCJPP00005027258.1"/>
        <property type="gene ID" value="ENSCJPG00005021149.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107316826"/>
    <dbReference type="KEGG" id="cjo:107316826"/>
    <dbReference type="CTD" id="55840"/>
    <dbReference type="GeneTree" id="ENSGT00390000017724"/>
    <dbReference type="OrthoDB" id="125903at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032783">
        <property type="term" value="C:super elongation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003711">
        <property type="term" value="F:transcription elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034243">
        <property type="term" value="P:regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027093">
        <property type="entry name" value="EAF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019194">
        <property type="entry name" value="Tscrpt_elong_fac_Eaf_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15970:SF7">
        <property type="entry name" value="ELL-ASSOCIATED FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15970">
        <property type="entry name" value="ELL-ASSOCIATED FACTOR EAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09816">
        <property type="entry name" value="EAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription elongation factor Eaf N-terminal" evidence="8">
        <location>
            <begin position="16"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="114"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="238"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005027258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="263" mass="28913" checksum="004162679C4FC049" modified="2022-01-19" version="1">MDGMAPPLLERKERVLQLGETFEKQPRCAFHTVRYDFKPASIDTACEGDLEVGKGEQVTITLPNIEGSTPPVTVFKGSKKPYLKECILIINHDTGECRLEKLSSNITVKKIRAEGSSKVQSRIEQQQQQIRNSAKNPNNKNSPPKDKMFPPSPMDDIEQELKAEASMMDQLSSSDSSSDSKSSSSSSSSSENSSSDSEDEEARPTLPLSMPYLQPQPTVSAVPHQAVPDEDASHNRSQENSGHMMNTLRNDLQLSESGSDSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UFW4</accession>
    <name>A0A8C2UFW4_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Leucine-rich repeat-containing protein 39</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Myosin-interacting M-band-associated stress-responsive protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LRRC39</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the sarcomeric M-band which plays a role in myocyte response to biomechanical stress. May regulate expression of other M-band proteins via an SRF-dependent pathway. Important for normal contractile function in heart.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Myofibril</location>
            <location evidence="5">Sarcomere</location>
            <location evidence="5">M line</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015725656.1">
        <property type="nucleotide sequence ID" value="XM_015870170.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015725657.1">
        <property type="nucleotide sequence ID" value="XM_015870171.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032302197.1">
        <property type="nucleotide sequence ID" value="XM_032446306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UFW4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005037541.1">
        <property type="protein sequence ID" value="ENSCJPP00005027824.1"/>
        <property type="gene ID" value="ENSCJPG00005021521.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107317458"/>
    <dbReference type="KEGG" id="cjo:107317458"/>
    <dbReference type="CTD" id="127495"/>
    <dbReference type="GeneTree" id="ENSGT00940000158998"/>
    <dbReference type="OrthoDB" id="442066at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031430">
        <property type="term" value="C:M band"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000249">
        <property type="entry name" value="Leucine rich repeat containing 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF2">
        <property type="entry name" value="LEUCINE RICH REPEAT CONTAINING 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0514">Muscle protein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="9">
        <location>
            <begin position="81"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005027824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="341" mass="39483" checksum="3A0D25F077BCCA8A" modified="2022-01-19" version="1">MTETAVCIGSFTAVKTLWEVRIQKINEELRKEKEFRERSAGRLLLVWEERAALAKLKEKVINEDGRAVLRIEEEEWKTLPSCLLKLVHLQEWQLHRTSLQRIPQFVGRFHNLVVLDLSRNSIESIPKEIGQLTGLQELLLSYNRIKSVPKEISNCISLERLELAVNRNICDLPPQLSDLKKLSHIDLCMNQFTTIPSALLNMPNLEWLDMGGNQLQMLPDAIDRMENLHTLWLQRNEINSLPETIVNMKNLSTLVLSNNKLKDIPSCMMHMTNLRFVNFRDNPLELEITLPPCENTEEEEQQEMFGIEFMHMYIQESLKKTGHAESCTSDAPILTANDERT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UG36</accession>
    <name>A0A8C2UG36_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Uridine phosphorylase</fullName>
            <ecNumber evidence="5">2.4.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">UPP2</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the reversible phosphorylytic cleavage of uridine to uracil and ribose-1-phosphate which can then be utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Shows broad substrate specificity and can also accept deoxyuridine and other analogous compounds.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>uridine + phosphate = alpha-D-ribose 1-phosphate + uracil</text>
            <dbReference type="Rhea" id="RHEA:24388"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; uracil from uridine (phosphorylase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the PNP/UDP phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.3" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2UG36"/>
    <dbReference type="Ensembl" id="ENSCJPT00005036230.1">
        <property type="protein sequence ID" value="ENSCJPP00005026733.1"/>
        <property type="gene ID" value="ENSCJPG00005020788.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161094"/>
    <dbReference type="UniPathway" id="UPA00574">
        <property type="reaction ID" value="UER00633"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045098">
        <property type="term" value="C:type III intermediate filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047847">
        <property type="term" value="F:deoxyuridine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004850">
        <property type="term" value="F:uridine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006248">
        <property type="term" value="P:CMP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006249">
        <property type="term" value="P:dCMP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046050">
        <property type="term" value="P:UMP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044206">
        <property type="term" value="P:UMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006218">
        <property type="term" value="P:uridine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd17763">
        <property type="entry name" value="UP_hUPP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018016">
        <property type="entry name" value="Nucleoside_phosphorylase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010059">
        <property type="entry name" value="Uridine_phosphorylase_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01719">
        <property type="entry name" value="euk_UDPppase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43691">
        <property type="entry name" value="URIDINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43691:SF8">
        <property type="entry name" value="URIDINE PHOSPHORYLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01232">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="7">
        <location>
            <begin position="203"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="286"/>
            <end position="289"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="365"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR610059-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005026733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="469" mass="49821" checksum="6A73504430622CF3" modified="2022-01-19" version="1">MAAPAAEEERPRAGRGAPGVEQRAGRGGGDLSRAEPRRALPGVPRPERRASSGDRCGLSPVRAAMTETTRYSGGGFVHIKNPHLEAMDEDVLYHLDLGTKTHDLPAMFGDVKVTAGPQPGVCRPCARPAVLPSLLAVPRPCVLIPDSGRSAAGARSAPVQPGCAGSAAVPGAAPRRHIPLRADPVPADPVPAVTDTSAFYTQFVCVGGSPNRMRAFAQFVHKELGLEGDGEDLADICAGTDRYAMYRVGPVLSISHGMGIPSVSIMLHELIKLLHHAKCRDVTIIRIGTSGGLGVQAGSVVITDRAVDACFQPRFEQVVLGDVVVRGTDLDGGLVEELLACSKDIPDFPTLVGHTMCTYDFYEGQGRLDGALCSFSNERKLEYLQRAHDAGVRNIEMESTAFAALCGLCGLRAAVVCVTLLDRLQGDQIRASHAVLQEYQQRPQRLVAAYIRSRLGLGAAAGNTRPDRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UJ24</accession>
    <name>A0A8C2UJ24_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase</fullName>
            <ecNumber evidence="4 15">4.2.1.134</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">HACD2</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(3R)-hydroxyhexadecanoyl-CoA = (2E)-hexadecenoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:39159"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:61526"/>
            <dbReference type="ChEBI" id="CHEBI:74278"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:39160"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:45812"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:83728"/>
            <dbReference type="ChEBI" id="CHEBI:85440"/>
            <dbReference type="EC" id="4.2.1.134"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:45813"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 15">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Endoplasmic reticulum membrane</location>
            <topology evidence="15">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the very long-chain fatty acids dehydratase HACD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.134" evidence="4 15"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2UJ24"/>
    <dbReference type="Ensembl" id="ENSCJPT00005036745.1">
        <property type="protein sequence ID" value="ENSCJPP00005027130.1"/>
        <property type="gene ID" value="ENSCJPG00005021067.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000062962"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102158">
        <property type="term" value="F:very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007482">
        <property type="entry name" value="Tyr_Pase-like_PTPLA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035:SF17">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04387">
        <property type="entry name" value="PTPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 15" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7 15" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 15" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 15" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005027130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="143" mass="17087" checksum="E1729908167D40F3" modified="2022-01-19" version="1">MSRVFLTWAVTHSVKEVQTEDSVLLFVVAWTITEIIRYSFYTFSLLNHLPYLIKWARYTLFIILYPMGVTGELLTIYAALPYVRQSGLYSISLPNKYNFSFDYYTFLILVMISYIPLFPQLYFHMLHQRRKVLSHTEEHKKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y4L1</accession>
    <name>A0A8C2Y4L1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cingulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">CGN</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Tight junction</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cingulin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015740175.1">
        <property type="nucleotide sequence ID" value="XM_015884689.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015740177.1">
        <property type="nucleotide sequence ID" value="XM_015884691.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015740178.1">
        <property type="nucleotide sequence ID" value="XM_015884692.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y4L1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005000103.1">
        <property type="protein sequence ID" value="ENSCJPP00005000048.1"/>
        <property type="gene ID" value="ENSCJPG00005000090.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107324569"/>
    <dbReference type="CTD" id="57530"/>
    <dbReference type="GeneTree" id="ENSGT00940000154489"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002928">
        <property type="entry name" value="Myosin_tail"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46349:SF4">
        <property type="entry name" value="CINGULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46349">
        <property type="entry name" value="CINGULIN-LIKE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01576">
        <property type="entry name" value="Myosin_tail_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0965">Cell junction</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0796">Tight junction</keyword>
    <feature type="domain" description="Myosin tail" evidence="7">
        <location>
            <begin position="914"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="54"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="783"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="849"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1134"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="221"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="270"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="794"/>
            <end position="811"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005000048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1172" mass="133584" checksum="502C1A90C59C2FA9" modified="2022-01-19" version="1">MERTAEKQSPVDYGVQIRFINDLQEPQKAPKARAKPGSYGVAVRVQGIAGQPFVVLNSGDKGGDSFGVQIKSDGSYPAGTASPRPPDPPPEPDLPENPYVRPHPSYSDEEHGAAPAPTRHKPHRKTGAELRRSQSHGNLPAATDEPTATGSRSSGTMSIARPTHRKSSGFGVAPSSDSESPGSRHAGGDIDTEPLSSVNSLISKFDGKVQQRGRAARRSRVAPEERKRSQSLDARSSVPDGRAVSAPAPLPTGGGRSAAGNRGTEERPQSKAQTELQLKSTPDLLRDQQEVAQPGSSEDPKELIYGILKEGSRDSSAMLKRKAALVLEKLQEVAVPTKGTTCSQPQHRALAQRVEELQERLDEESKLRQKLELTKERGTARALEEAQEESARLRAVLEKRMQELQRSSKELEEAKAAQMRAEEQLKAMRTEMGTAMDTSALCKELEEAQEELEEALSSRQRLEEHLRLRERELTALKGALKEEVANHDRELERVRLQCHSDMEQLRRSVEDISQNRADLESEKQKIGAVVRNLQRELEESAEETGHWREMFQRNKDELRAAKQELLQVKMEREEFEEELRELRERFAAAREEVERARSSAADPEEMEALRMELRRAQKAQQELMEEKEQREEVVRKREEELQVLRSAVQDEAQSHSGAMEQCLRDMERLREERDEAVRAKVSLEGEKKTAEAALQKLQEQHEELQRKVQGMEVQLKDYERMGENWEGSQARLREKVTKLEAERRLAEESLGEATDREQELLRAQRFLETRLDEAQRGMARLTQEQRELSASLQDEQRQKEQLKRAKSELEEQKRLLDRSTEKLNRELEQMTEESNRSLAALKAQLEECKEKSRKEITDSQKQAKDRSAEVEKMQFSLGRLQDEVSRLKQALQDSQAERDGALLERDVMLQRLRGLEEEADAKRRSQDDRSRQLKALEDKSKRLEEELEEERSTTELLTERINRSRDQIDQLRAELLQERSSRQDLECDKVSLERQNKELKSRLASSEGMQKVGSSVSQLEARLEELQDRLQAEEREKSVLQSSNRKLERKVKELTIQIDDERQHVNDQKDQLSLRVKALKRQVDEAEEEIERLEAARKKAQRELEEQHELNEQLQGRIKALEKEAWRRAAHAATDSLLQDDALSSDEDLDSAYGPSSIASLLNEANLQTSSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y611</accession>
    <name>A0A8C2Y611_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">KLF transcription factor 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">KLF6</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015708600.1">
        <property type="nucleotide sequence ID" value="XM_015853114.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y611"/>
    <dbReference type="Ensembl" id="ENSCJPT00005005557.1">
        <property type="protein sequence ID" value="ENSCJPP00005003073.1"/>
        <property type="gene ID" value="ENSCJPG00005003316.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107308916"/>
    <dbReference type="KEGG" id="cjo:107308916"/>
    <dbReference type="CTD" id="1316"/>
    <dbReference type="GeneTree" id="ENSGT00940000158085"/>
    <dbReference type="OrthoDB" id="4748970at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001650">
        <property type="term" value="C:fibrillar center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21586">
        <property type="entry name" value="KLF6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000021">
        <property type="entry name" value="Basic krueppel-like factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000018">
        <property type="entry name" value="Krueppel-like factor 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF50">
        <property type="entry name" value="KRUEPPEL-LIKE FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="200"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="230"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="81"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="174"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
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    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
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    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005003073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="283" mass="31988" checksum="F087E9BE5E3DBF13" modified="2022-01-19" version="1">MDVLPMCSIFQELQIVHDTGYFSALPSLEEYWQQTCLELERYLQSEPCYVSASEIKFDNQEDLWTKIILAREKKEESELKIACVPKEDSPTSQNLETNSLNSDVSSESSDSSEELSPTTKFTSDPISDVLTNSGNLCSSVTSTPPSSPELSKEPSSQLWNCTPGELHSPGKIRTGTAGKTAEKGTPANGDTSPDGRRRVHRCHFNGCRKVYTKSSHLKAHQRTHTGEKPYRCSWEGCEWRFARSDELTRHFRKHTGAKPFKCSHCDRCFSRSDHLALHMKRHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y6B0</accession>
    <name>A0A8C2Y6B0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="26">Integrin beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="33" type="primary">ITGB1</name>
    </gene>
    <organism evidence="33 34">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="33" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="33" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="33" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="26">Cell membrane</location>
            <topology evidence="26">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Invadopodium membrane</location>
            <topology evidence="3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cell projection</location>
            <location evidence="4">Lamellipodium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Ruffle membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Melanosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 26">Belongs to the integrin beta chain family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y6B0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005005637.1">
        <property type="protein sequence ID" value="ENSCJPP00005003122.1"/>
        <property type="gene ID" value="ENSCJPG00005003352.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286983"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0150053">
        <property type="term" value="C:cerebellar climbing fiber to Purkinje cell synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043197">
        <property type="term" value="C:dendritic spine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030175">
        <property type="term" value="C:filopodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034665">
        <property type="term" value="C:integrin alpha1-beta1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034680">
        <property type="term" value="C:integrin alpha10-beta1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034681">
        <property type="term" value="C:integrin alpha11-beta1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034666">
        <property type="term" value="C:integrin alpha2-beta1 complex"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034667">
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034668">
        <property type="term" value="C:integrin alpha4-beta1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034674">
        <property type="term" value="C:integrin alpha5-beta1 complex"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034675">
        <property type="term" value="C:integrin alpha6-beta1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034677">
        <property type="term" value="C:integrin alpha7-beta1 complex"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034679">
        <property type="term" value="C:integrin alpha9-beta1 complex"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034682">
        <property type="term" value="C:integrin alphav-beta1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014704">
        <property type="term" value="C:intercalated disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042470">
        <property type="term" value="C:melanosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035748">
        <property type="term" value="C:myelin sheath abaxonal region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031594">
        <property type="term" value="C:neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032587">
        <property type="term" value="C:ruffle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098685">
        <property type="term" value="C:Schaffer collateral - CA1 synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097060">
        <property type="term" value="C:synaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019960">
        <property type="term" value="F:C-X3-C chemokine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098639">
        <property type="term" value="F:collagen binding involved in cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001968">
        <property type="term" value="F:fibronectin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098640">
        <property type="term" value="F:integrin binding involved in cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043236">
        <property type="term" value="F:laminin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002020">
        <property type="term" value="F:protease binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990782">
        <property type="term" value="F:protein tyrosine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048675">
        <property type="term" value="P:axon extension"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071711">
        <property type="term" value="P:basement membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007161">
        <property type="term" value="P:calcium-independent cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060912">
        <property type="term" value="P:cardiac cell fate specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055007">
        <property type="term" value="P:cardiac muscle cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060379">
        <property type="term" value="P:cardiac muscle cell myoblast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023035">
        <property type="term" value="P:CD40 signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002042">
        <property type="term" value="P:cell migration involved in sprouting angiogenesis"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033631">
        <property type="term" value="P:cell-cell adhesion mediated by integrin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071404">
        <property type="term" value="P:cellular response to low-density lipoprotein particle stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021953">
        <property type="term" value="P:central nervous system neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048813">
        <property type="term" value="P:dendrite morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021943">
        <property type="term" value="P:formation of radial glial scaffolds"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008354">
        <property type="term" value="P:germ cell migration"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034113">
        <property type="term" value="P:heterotypic cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050901">
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            <dbReference type="ARBA" id="ARBA00023037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PIRSR" id="PIRSR002512-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="RuleBase" id="RU000633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="SMART" id="SM00187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="SMART" id="SM00423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="31">
        <source>
            <dbReference type="SMART" id="SM01241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="32">
        <source>
            <dbReference type="SMART" id="SM01242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005003122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="803" mass="88493" checksum="E8C28316A1E864F9" modified="2022-01-19" version="1">MAETNLTLLTWAGILCCLVWSGSAQQGGSDCIKANAKSCGECIQAGPNCGWCKKTDFLQEGEPTSARCDDLAALKSKGCPEQDIENPRGSKRVLEDREVTNRKIGAAEKLKPEAITQIQPQKLVLQLRVGEPQTFSLKFKRAEDYPIDLYYLMDLSYSMKDDLENVKSLGTALMREMEKITSDFRIGFGSFVEKTVMPYISTTPAKLRNPCTGDQNCTSPFSYKNVLSLTSEGNKFNELVGKQHISGNLDSPEGGFDAIMQVAVCGDQIGWRNVTRLLVFSTDAGFHFAGDGKLGGIVLPNDGKCHLENNMYTMSHYYDYPSIAHLVQKLSENNIQTIFAVTEEFQAVYKELKNLIPKSAVGTLSSNSSNVIQLIIDAYNSLSSEVILENSKLPKGVTISYKSYCKNGVNDTQEDGRKCSNISIGDEVRFEINVTANECPKKGQNETIKIKPLGFTEEVEIGLQFICECMCQSEGEPNSPACHDGNGTFECGACRCNEGRIGRLCECSTDEVNSEDMDAYCRRENSTEICSNNGECICGQCVCKKRENTNEVYSGKYCECDNFNCDRSNGLICGGNGICKCRVCECFPNFTGSACDCSLDTTPCLAANGQICNGRGTCECGTCNCTDPKFQGPTCEMCQTCLGVCAEHKDCVQCRAFDKGEKKETCSQECMHFNMTRVESRDKLPQPGQPDPLSHCKEKDVDDCWFYFTYSVNSNGEANVHVVETPECPSGPDIIPIVAGVVAGIVLIGLALLLIWKLLMIIHDRREFAKFEKEKMNAKWDTGENPIYKSAVTTVVNPKYEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y6G8</accession>
    <name>A0A8C2Y6G8_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y6G8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005006174.1">
        <property type="protein sequence ID" value="ENSCJPP00005003494.1"/>
        <property type="gene ID" value="ENSCJPG00005003659.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome LGE22C19W28_E50C23"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005003494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="126" mass="13384" checksum="B15A229B95BE15AA" modified="2022-01-19" version="1">MGQWVDSELWLPTILPWLILHCSLAAFCYHRWPQSTPRCHQKKTVARMDATDGGPRFPEEGGFSSSSACLGGKNKVTFSTVARGCRGPAGNAGGFSSRSLYSLGGCKSTPSCAGRKEAAVSGEAMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y8T6</accession>
    <name>A0A8C2Y8T6_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">U-box domain containing 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">UBOX5</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015718458.1">
        <property type="nucleotide sequence ID" value="XM_015862972.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015718459.1">
        <property type="nucleotide sequence ID" value="XM_015862973.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015718461.1">
        <property type="nucleotide sequence ID" value="XM_015862975.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015718462.1">
        <property type="nucleotide sequence ID" value="XM_015862976.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032300248.1">
        <property type="nucleotide sequence ID" value="XM_032444357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y8T6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005012859.1">
        <property type="protein sequence ID" value="ENSCJPP00005008496.1"/>
        <property type="gene ID" value="ENSCJPG00005007575.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107314089"/>
    <dbReference type="KEGG" id="cjo:107314089"/>
    <dbReference type="CTD" id="22888"/>
    <dbReference type="GeneTree" id="ENSGT00510000049555"/>
    <dbReference type="OrthoDB" id="20295at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034450">
        <property type="term" value="F:ubiquitin-ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd16537">
        <property type="entry name" value="RING-HC_RNF37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16660">
        <property type="entry name" value="RING-Ubox_RNF37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000163">
        <property type="entry name" value="Putative ring finger protein 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039925">
        <property type="entry name" value="RNF37_RING-Ubox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039847">
        <property type="entry name" value="Ubox5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045696">
        <property type="entry name" value="Ubox5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13492">
        <property type="entry name" value="RING FINGER PROTEIN 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13492:SF2">
        <property type="entry name" value="RING FINGER PROTEIN 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19318">
        <property type="entry name" value="DUF5918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="U-box" evidence="6">
        <location>
            <begin position="258"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="476"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005008496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="534" mass="58824" checksum="62C26A557944DF8F" modified="2022-01-19" version="1">MVINVCLPQFKPRIHCNKISADGYEVENLISEDLARRNRGFRSEYFIKPPVHVTISFPFNIEICRINIDISSGGYQAFSGLEVYTSTSCNKTSWQSPEAQFSGLAGQPVSDKDVFTLVGKAVLKNQSKVTFGHRGFKPRPPFLQMENVLSYPGAVSQDLWNKGPSSLSNVSHLKICITHVAGGGLPGIKRLEVWGQPAKSCPQEVIEGIFQVASQCVAQDVGTLKPELWTPMESDCVPFSTNDSEQQALRKLVDVIQDIPEEFLDPITLEIMTFPMLLPSGKVIDQSTLEKCNRSEASWGRVPSDPFTGVAFSQHSQPLPHPTLKARIDHFLLQHSIPGTNLLGRAHASEMLIPSSVTSSLKRKMDCMDPSSVQPLYFSSTNLLVTSTSENSAKKMKTDSDSHLIQMDCSTDLLSHEQKLSESLDTALNSALSSMPSFTAKLMKSQQQVQGEGGCSTSWNTGSILEHSRSSQTQGCTSCGKTFSPYFKTEPIYQLPCGHLMCRPCLAEEQKALSILCGSCKRSVATHDIRRVHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y9F6</accession>
    <name>A0A8C2Y9F6_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Solute carrier family 39 member 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">SLC39A10</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZIP transporter (TC 2.A.5) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y9F6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005014560.1">
        <property type="protein sequence ID" value="ENSCJPP00005009793.1"/>
        <property type="gene ID" value="ENSCJPG00005008563.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000169482"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140410">
        <property type="term" value="F:monoatomic cation:bicarbonate symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071578">
        <property type="term" value="P:zinc ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050799">
        <property type="entry name" value="ZIP_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12191">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12191:SF14">
        <property type="entry name" value="ZINC TRANSPORTER ZIP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034667956" evidence="8">
        <location>
            <begin position="26"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="406"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="440"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="489"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="726"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="753"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="795"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="123"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="273"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="522"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="633"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="174"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="211"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="226"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="283"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="301"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="317"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="528"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="633"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005009793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="825" mass="93562" checksum="2721CA812982A949" modified="2022-01-19" version="1">MKVHMHTKFCIVCLLTFIFHQCSHCHKDGRDHGPEEGHEDHHNCYQISETKFSASEAENEQKYYIEKIFDRYGENGRLSFFGLEKLLMSLGLGEVKVVVINHDDIGHDHVSHLYALEVQEGKHFHSHNHPHSHSDSKNQTVVGMSEKRNHKCNSERDAVVSSIKGDGKHIHDQSHHRHHHHPHPHHHLDHNGTHHSRNDSVIHDEHGEQNHGPSTETNTTQDQRERKQRKQKKKRKKISETSGDAAQDCPPNHHLGDQCEHNRVHKHDHVHDTSHFHVHHREHSGDRSTNHGHQDSSLGSEDGHHRTSKREAPCKHTGVRKHTISARSRKDRNEDERDRECLNVTQLLRRYGLETSSPISPEFFIYLCPALLYQIDRRLCIAHYDELEDFMKSKTASIENEDKTGASAWVCGIISITVISLLSLLGVILIPIINQWCFKFLLTFLVALAVGTMSGDALLHLLPHSHGGHNHSHHHGQENDGFLEENDPVLKGLVALGGIYVLFIIEHCIRMYKHYNKQKSKQKWCKNKQSEESPIGRKLSDQKLNNRPDTDWLQLKPLAGADDSVLSEDRLNETELTDLDGQLESPPKNFLSIEEENNMHHSHNDVLRAAQEHDLHDLEYDSHGEDKMIARKHSHHWHHKHSHHSHGHCHSGKDMKDTGIANIAWMVIMGDGIHNFSDGLAIGAAFSAGLTGGISTSIAVFCHELPHELGDFAVLLKAGMTVKQAIVYNLLSAMMAYIGMLIGTAVGQYANNITLWIFAVTAGMFLYVALVDMLPEMLHGDGDNEEHGYCPVGQFILQNLGLLLGFAIMLVIALYEDKIVLNIQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YAF1</accession>
    <name>A0A8C2YAF1_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Glycerol-3-phosphate acyltransferase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC107313488</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">Glycerolipid metabolism; triacylglycerol biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015717288.1">
        <property type="nucleotide sequence ID" value="XM_015861802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YAF1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005017335.1">
        <property type="protein sequence ID" value="ENSCJPP00005011905.1"/>
        <property type="gene ID" value="ENSCJPG00005010177.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107313488"/>
    <dbReference type="KEGG" id="cjo:107313488"/>
    <dbReference type="GeneTree" id="ENSGT01030000234574"/>
    <dbReference type="OrthoDB" id="10051137at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004366">
        <property type="term" value="F:glycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07991">
        <property type="entry name" value="LPLAT_LPCAT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045252">
        <property type="entry name" value="LPCAT1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23063:SF10">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23063">
        <property type="entry name" value="PHOSPHOLIPID ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="14" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="17">
        <location>
            <begin position="226"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005011905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="446" mass="50044" checksum="53D5EC735AA170D8" modified="2022-01-19" version="1">MEELGSLALSLGMAWLSLVITLIVLPSALGISLGISEAYMWVLVKTLEWATIRIEKGVKKPQPQILKIPAANGIIERDETPMEKEITGLHRMEFQFADMFYFCRKGFEAIVEDEVTQRFSSEELVSWNLLTRTNVNFHYVSLRLTVVWVIGVIVRYCFLLPLRFTLAAIGIISMIVGTTVVGQLPNGSLKNYLSEVVHLTCSRILVRALSGTIHYHNKENKPQKGGICVANHTSPIDAIILTNDGCYAMVGQVHGGLMGVIQRATVKACPHVWFERSEIKDRHLVTKRLREHVADKNKLPILIFPEGTCINNTSVMMFKKGSFEIGGTIYPVAIKYDPQFGDAFWNSSKYNIVSYLLRIMTSWAIVCHVWYMPPMVRNEGEDAVQFANRVRSAIARQGGLTELPWDGGLKRAKVKDSFKEEQQKNYSKMLVRNGSQGSLSAGTESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YAP9</accession>
    <name>A0A8C2YAP9_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Trans-2,3-enoyl-CoA reductase-like</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Steroid 5-alpha-reductase 2-like 2 protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">TECRL</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the steroid 5-alpha reductase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015717059.1">
        <property type="nucleotide sequence ID" value="XM_015861573.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YAP9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005018091.1">
        <property type="protein sequence ID" value="ENSCJPP00005012482.1"/>
        <property type="gene ID" value="ENSCJPG00005010619.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107313405"/>
    <dbReference type="KEGG" id="cjo:107313405"/>
    <dbReference type="CTD" id="253017"/>
    <dbReference type="GeneTree" id="ENSGT00950000182886"/>
    <dbReference type="OrthoDB" id="540503at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17125">
        <property type="entry name" value="Ubl_TECRL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000131">
        <property type="entry name" value="trans-2,3-enoyl-CoA reductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001104">
        <property type="entry name" value="3-oxo-5_a-steroid_4-DH_C"/>
    </dbReference>
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        <property type="entry name" value="SRD5A/TECR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049127">
        <property type="entry name" value="TECR-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047822">
        <property type="entry name" value="TECRL_Ubl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556:SF27">
        <property type="entry name" value="TRANS-2,3-ENOYL-COA REDUCTASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02544">
        <property type="entry name" value="Steroid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21696">
        <property type="entry name" value="TECR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="TECR-like N-terminal" evidence="13">
        <location>
            <begin position="59"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal" evidence="12">
        <location>
            <begin position="211"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007742"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00070012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00079977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF21696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005012482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="362" mass="41598" checksum="2628E79C1F2DE327" modified="2022-01-19" version="1">MLRRRKTSASELKRDLSAHGGALSMSQNTRSFFNFSQLVLSAGHLKPPPALKHSKITYFEVEILDVHSKKQICIVDKIPPSSTLLDVKHKFHKACPQWYPSRVGLQLERNGPYLKDSVNIQSLAASSIITLYFTDLGQQVGWTTFFLTEYTGPLLIYLLFYIRLSTIYDQVESTKNFRHPVVHLACFCHCLHYIRHLLETLFVHKFSGGHTPLKNMIKGCAFYWGFTSWIAYYINHPRYTPPSFGHRQVSLAALAFLMCEAGNHFINVALAHQNHSGNKACFPSPTYNPFTWLFLLVSCPNYTYEVGSWISFTVMTQTLPVGIFAFLMVIQMSLWAQKKHKLYLKKFYPEVRRKAAMIPIVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YB27</accession>
    <name>A0A8C2YB27_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Homer protein 3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YB27"/>
    <dbReference type="Ensembl" id="ENSCJPT00005019082.1">
        <property type="protein sequence ID" value="ENSCJPP00005013252.1"/>
        <property type="gene ID" value="ENSCJPG00005011190.1"/>
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        <property type="component" value="Chromosome 28"/>
    </dbReference>
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        <property type="term" value="F:G protein-coupled glutamate receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR045027">
        <property type="entry name" value="Homer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10918">
        <property type="entry name" value="HOMER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005013252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="171" mass="19544" checksum="3D93EB44024BA5F5" modified="2022-01-19" version="1">LHSSVSEVQWEAEFFSLQDNNSKLVAALHEANANVDQWKKQLAAYQEETETLRQRVTELESQGAHDSSSENNKEELSQTLEELELLIKAKDEHVSVPGQPPHCNCVLWQELEARNAELERRLHLAEQTLAETLSEREKIQNEVTKVAEIMDVKIFELSEIRQGLAKLVESN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YB38</accession>
    <name>A0A8C2YB38_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YB38"/>
    <dbReference type="Ensembl" id="ENSCJPT00005019170.1">
        <property type="protein sequence ID" value="ENSCJPP00005013324.1"/>
        <property type="gene ID" value="ENSCJPG00005011257.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00960000189620"/>
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        <property type="component" value="Chromosome 21"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:response to muscle activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Perm1"/>
    </dbReference>
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        <property type="entry name" value="PGC-1 AND ERR-INDUCED REGULATOR IN MUSCLE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47282:SF1">
        <property type="entry name" value="PGC-1 AND ERR-INDUCED REGULATOR IN MUSCLE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034648105" description="Secreted protein" evidence="1">
        <location>
            <begin position="16"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005013324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="84" mass="9181" checksum="38AEC274B42A882D" modified="2022-01-19" version="1">MCLVFCAFASWAVKTSDLQAPDAWKTGVCGVICCIERSSVPQFYPRTAFAELVGTKVALRQHQDGIKVAPGCWEQCSQRRSPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YBV1</accession>
    <name>A0A8C2YBV1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Probable G-protein coupled receptor 34</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">GPR34</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">G-protein-coupled receptor of lysophosphatidylserine (LysoPS) that plays different roles in immune response. Acts a damage-sensing receptor that triggers tissue repair upon recognition of dying neutrophils. Mechanistically, apoptotic neutrophils release lysophosphatydilserine that are recognized by type 3 innate lymphoid cells (ILC3s) via GPR34, which activates downstream PI3K-AKT and RAS-ERK signaling pathways leading to STAT3 activation and IL-22 production. Plays an important role in microglial function, controlling morphology and phagocytosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015740485.1">
        <property type="nucleotide sequence ID" value="XM_015884999.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YBV1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005021604.1">
        <property type="protein sequence ID" value="ENSCJPP00005015211.1"/>
        <property type="gene ID" value="ENSCJPG00005012633.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107324720"/>
    <dbReference type="KEGG" id="cjo:107324720"/>
    <dbReference type="CTD" id="2857"/>
    <dbReference type="GeneTree" id="ENSGT01110000267167"/>
    <dbReference type="OrthoDB" id="65789at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045028">
        <property type="term" value="F:G protein-coupled purinergic nucleotide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15148">
        <property type="entry name" value="7tmA_GPR34-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000150">
        <property type="entry name" value="probable G-protein coupled receptor 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048057">
        <property type="entry name" value="GPR34_7tmA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24233:SF1">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24233">
        <property type="entry name" value="P2Y PURINOCEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01157">
        <property type="entry name" value="P2YPURNOCPTR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 13" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 13" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="15">
        <location>
            <begin position="63"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
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    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00035691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="381" mass="43797" checksum="B727CE547821DEB2" modified="2022-01-19" version="1">MAASSVDLLTILSHKEGFWGNQTVLAMNAPEIRRNASCSLEDNALSYAFILFYSVIFVIGLVGNIIALFAFLCIHQKRNSIQVYLLNVAIADLLLIFCLPFRILYHIRNNTWMFGRILCKIVGTLFYMNMYISIVLLGLISLDRYVKINKSVKRPNMLTTTRSIHICCIVWAVALTGFSLVVVPSLFMSEVSNSTLCFHYRHKKNAMTEAILNYIIVIIFWTVFFLLILSYVKIAKNLLKISRKRANFPNAVKYTQTARNSFIVLIIFTVCFVPYHIFRFVYITSQLQNPSCYWKGVIHTCNEVMLIFSSFNSCLDPVMYFLMSRSVRKTVLQLICRRIHRDTSLTLESTSEIKLGQYTQERLSTTTPHSSSVKKKSDLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YD24</accession>
    <name>A0A8C2YD24_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Coagulation factor VII</fullName>
            <ecNumber evidence="3">3.4.21.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Serum prothrombin conversion accelerator</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="29" type="primary">F7</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="29" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="29" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="21">Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa also converts factor IX to factor IXa in the presence of tissue factor and calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Selective cleavage of Arg-|-Ile bond in factor X to form factor Xa.</text>
            <dbReference type="EC" id="3.4.21.21"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="23">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.21" evidence="3"/>
    <dbReference type="RefSeq" id="XP_032297887.1">
        <property type="nucleotide sequence ID" value="XM_032441996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YD24"/>
    <dbReference type="Ensembl" id="ENSCJPT00005024669.1">
        <property type="protein sequence ID" value="ENSCJPP00005017697.1"/>
        <property type="gene ID" value="ENSCJPG00005014430.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107307824"/>
    <dbReference type="KEGG" id="cjo:107307824"/>
    <dbReference type="CTD" id="2155"/>
    <dbReference type="GeneTree" id="ENSGT00940000154474"/>
    <dbReference type="OrthoDB" id="10004439at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905286">
        <property type="term" value="C:serine-type peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007596">
        <property type="term" value="P:blood coagulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002690">
        <property type="term" value="P:positive regulation of leukocyte chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010641">
        <property type="term" value="P:positive regulation of platelet-derived growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050927">
        <property type="term" value="P:positive regulation of positive chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032008">
        <property type="term" value="P:positive regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000259">
        <property type="entry name" value="Coagulation factor VII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000420">
        <property type="entry name" value="Coagulation factor VII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000013">
        <property type="entry name" value="Coagulation factor X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.740.10:FF:000001">
        <property type="entry name" value="vitamin K-dependent protein S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.740.10">
        <property type="entry name" value="Coagulation Factor IX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017857">
        <property type="entry name" value="Coagulation_fac-like_Gla_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035972">
        <property type="entry name" value="GLA-like_dom_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000294">
        <property type="entry name" value="GLA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012224">
        <property type="entry name" value="Pept_S1A_FX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050442">
        <property type="entry name" value="Peptidase_S1_coag_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24278">
        <property type="entry name" value="COAGULATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24278:SF26">
        <property type="entry name" value="COAGULATION FACTOR VII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14670">
        <property type="entry name" value="FXa_inhibition"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00594">
        <property type="entry name" value="Gla"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001143">
        <property type="entry name" value="Factor_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00010">
        <property type="entry name" value="EGFBLOOD"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00001">
        <property type="entry name" value="GLABLOOD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00069">
        <property type="entry name" value="GLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57630">
        <property type="entry name" value="GLA-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00011">
        <property type="entry name" value="GLA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50998">
        <property type="entry name" value="GLA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="16" id="KW-0094">Blood coagulation</keyword>
    <keyword evidence="15" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="18 23" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 23" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0301">Gamma-carboxyglutamic acid</keyword>
    <keyword evidence="19" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0356">Hemostasis</keyword>
    <keyword evidence="13 24" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 24" id="KW-0645">Protease</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="14 24" id="KW-0720">Serine protease</keyword>
    <keyword evidence="11 25" id="KW-0732">Signal</keyword>
    <keyword evidence="17" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="25">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034684245" description="Coagulation factor VII" evidence="25">
        <location>
            <begin position="24"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Gla" evidence="28">
        <location>
            <begin position="40"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="26">
        <location>
            <begin position="86"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="27">
        <location>
            <begin position="192"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="22">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="22">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="22">
        <location>
            <position position="377"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="23">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012069"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00015530"/>
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            <dbReference type="ARBA" id="ARBA00022525"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022536"/>
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            <dbReference type="ARBA" id="ARBA00022670"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022685"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022696"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022729"/>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023084"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00030307"/>
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    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
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    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
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    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50240"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005017697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="425" mass="47845" checksum="BF2657BD15FA2AD5" modified="2022-01-19" version="1">MVSRQCVVLLLCFPLLVPPSLEAVFLKQEEANSIFQRHRRANSFFEEIKLGSLERECMEEKCSFEEAREIYRDDERTQEFWHIYSDPNQCDSNPCQNGGSCDDQFQDYVCRCPPEYEGKSCEIAVAENLKCIYDNGGCEQYCADKQSEKRVCFCAEGYALASDGVSCIPQVKYPCGKIPVLAKKNVTARGRIVGGVTCPPGECPWQALIIQDKKGKCGGSLLSPEWVVTAAHCLDYTHTKQLRVRLGEYSIKVDEKTEQERAVSKIIRHEEYINGQVNHDIALLKLETPVNLTDFVVPICLPEKRFAVYELSSIKFSTVSGWGRLLDGGATSTFLMRVDLPRVKTQECEKQAKLNVTENMFCAGDLTGKKDSCKGDSGGPHATKYKNTWFLTGIVSWGKGCAVEGSYGVYTRVSRYIDWLKKHME</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YFW1</accession>
    <name>A0A8C2YFW1_COTJA</name>
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        <recommendedName>
            <fullName evidence="1">Myb/SANT-like DNA-binding domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">MSANTD1</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015718440.1">
        <property type="nucleotide sequence ID" value="XM_015862954.2"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_032444508.1"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A8C2YFW1"/>
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        <property type="protein sequence ID" value="ENSCJPP00005023487.1"/>
        <property type="gene ID" value="ENSCJPG00005018622.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107314076"/>
    <dbReference type="CTD" id="345222"/>
    <dbReference type="GeneTree" id="ENSGT00390000002245"/>
    <dbReference type="OrthoDB" id="6081971at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000135">
        <property type="entry name" value="Myb/SANT-like DNA-binding domain containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
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        <property type="entry name" value="Myb/SANT-like_DNA-bd_dom_prot"/>
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    <dbReference type="InterPro" id="IPR044822">
        <property type="entry name" value="Myb_DNA-bind_4"/>
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    <proteinExistence type="predicted"/>
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            <begin position="22"/>
            <end position="109"/>
        </location>
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            <begin position="120"/>
            <end position="147"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
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            <begin position="124"/>
            <end position="144"/>
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            <dbReference type="ARBA" id="ARBA00070622"/>
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    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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            <dbReference type="Pfam" id="PF13837"/>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="259" mass="30576" checksum="F421F07896DFD078" modified="2022-01-19" version="1">MAAAEIPSYIVSSQTEKHRRARNWTDAEMRGLMLVWEEFFDELKQTKRNAKVYEKMANKLFEMTGEIRHGEEIKIKITNMTFQYRKLKCMTDSETVAPDWPYYKTIDRILSKVTDHSDVKMHENQQPGPSTSQTEASQSPSAKSTPLYLPYNQFTYEGREECFEDEHSESSSSLLSYKLRTEERPVKKRKMQSCSFQKKKLKLMEAMLEEQKKLSRAMEETCREVRRILDQQNIIQVQSLQLQERMMNLLEKMISKSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YHY2</accession>
    <name>A0A8C2YHY2_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Otopetrin 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">OTOP2</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the otopetrin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2YHY2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005037589.1">
        <property type="protein sequence ID" value="ENSCJPP00005027868.1"/>
        <property type="gene ID" value="ENSCJPG00005021547.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156691"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015252">
        <property type="term" value="F:proton channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004878">
        <property type="entry name" value="Otopetrin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21522">
        <property type="entry name" value="PROTON CHANNEL OTOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21522:SF35">
        <property type="entry name" value="PROTON CHANNEL OTOP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03189">
        <property type="entry name" value="Otopetrin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="272"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="360"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="487"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="528"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="449"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="451"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005027868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="557" mass="62775" checksum="E2185976EEAC9C47" modified="2022-01-19" version="1">MSPDVAQGTLQPHQPSAPGSKEVWKKGGRMFSILLAVHLALLACTLVSSGAFERIAVHDYDVFFLLTVMMLVVIIWIIFYLVSTSRCPDAILCKDSHAGPIWLRGGLILFAIFSLVMDVFKIGYYSSFYSCLSAIKIMYPIVQAIFVVVQTYFLWISAKDCVHVHLNVTRCGLMLTLTTNLAVWMSAVTDESVHKAHSKLKKNTTEELFSSTEACNCNSQICQIFKNGYYWLYPFNIEYSLFASAMVYVMWKNVGRFIDHHSHHIQHLKFKLFRRTFFVGIVLGLIILVSGLGVLIVYEVQVNSSTEPSKKSQALTMYYIFNIVCLGLMSLVCIGGSVIYRFDKRDMDRHKNPTRTLDVALLMGAALGQYAISYYSIVAIVASTPRDAISALNLTYALLMIAQHTFQNIFIIEGLHRQPPKEDHKHSSHQKELYGLTFVNVNAVSLRMPDSSSASAPSTTPGSEGTHPSDLVRSLTAPKKINWRRKFLREISMFLLLCNIILWIMPAFGARPHFDNDTELNFYGDSMWPAIVDICLPFGIFYRMHAVASLLEVCIMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SL20</accession>
    <name>A0A8C2SL20_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SET binding factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">SBF1</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSCJPT00005000652.1">
        <property type="protein sequence ID" value="ENSCJPP00005000345.1"/>
        <property type="gene ID" value="ENSCJPG00005000380.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155263"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd13340">
        <property type="entry name" value="PH-GRAM_MTMR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01235">
        <property type="entry name" value="PH_Sbf1_hMTMR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14588">
        <property type="entry name" value="PTP-MTMR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000093">
        <property type="entry name" value="SET binding factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.200:FF:000004">
        <property type="entry name" value="SET binding factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11500:FF:000006">
        <property type="entry name" value="SET binding factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005112">
        <property type="entry name" value="dDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030564">
        <property type="entry name" value="Myotubularin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010569">
        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022096">
        <property type="entry name" value="SBF1/SBF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005113">
        <property type="entry name" value="uDENN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807">
        <property type="entry name" value="MYOTUBULARIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807:SF43">
        <property type="entry name" value="MYOTUBULARIN-RELATED PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03455">
        <property type="entry name" value="dDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06602">
        <property type="entry name" value="Myotub-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12335">
        <property type="entry name" value="SBF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03456">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00801">
        <property type="entry name" value="dDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00799">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00568">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00800">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51339">
        <property type="entry name" value="PPASE_MYOTUBULARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="7">
        <location>
            <begin position="25"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Myotubularin phosphatase" evidence="8">
        <location>
            <begin position="1151"/>
            <end position="1684"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="6">
        <location>
            <begin position="1851"/>
            <end position="1955"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1104"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1771"/>
            <end position="1790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1813"/>
            <end position="1845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1119"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1813"/>
            <end position="1828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1834"/>
            <end position="1845"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005000345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1957" mass="220214" checksum="6845DBAB9AEDA04B" modified="2022-01-19" version="1">MQLQPLMPFLFLQGFGVSPAVARHAAPASNALLVPAGSGDGQGQILQRFPEKDWEDNPFPQGIELFCQPSGWQLFTERNPPTFFVAVLTDINSERHYCACFTFWEPVESTQPQSHPRNGEEEEEESASPVQPAQLFAPKSLVLVSRLDHAEVFRNSLGLIYTIYVDGLNVSLENVIGNLLTCTIPITGGAQRTISLGAGDRQVIQTPINDSLPVSSCSVALLFRQLGITNVLYLFCAALTEHKILFLSSSYQRLTDACRALLALMFPLKYSFTYVPILPAQLLEVLSTPTPFIIGVHSIFQSETQELLDVVIADLDGGTVNVPECVHISLLPEPLLQQTREALSMVLDPELEVADLAFPPSTISASSLKMQDKEIRAVFLRLFAQLLQGYRWCLHIIRIHPEPVIRFHKAAFLGQRGLTEDDFLTKVLEGMAFAGFVTERGAPYRSIDLFDELVAYEVKRMRAEEGNKQKILRHIKELAEKLYKNENPYPAVTMHKVQKPTEGCHLRLHQKPFPRLDEGTVQWIIDQATAKLQTAPPAVKAEKKCMVPSGPPIAAILERNGNALANSARRLEVVRNCISYVFENKMLEAKKLFPAVLRAMKGRAARHCLTQELNLHVQQNRAVLDHQQFDFIVRMMNCCLQDCTAMDEHGIAAALLPLVTAFCRKLSSGITQFAYSCVQEHVVWTNIQFWEAMFYSDVQNHIRALYLDSSEENHADEESTEEPQEARSALEIASEQLRLWPTMSREKQQELIQKEESTVFSQAIHYANRMSYLLLPLDTSKNRLLRSSGLGDVESVSNSFVTNSIAGSVAESYDTESGFEDAESSDVANYVVRFINRFVDKVCTESGVTNEHLKGLHVMIPDIVQMHIETLDAVHRESKRLPPIQKPKLLRPNLLVGEECVMEGLRVYLMPDGREEAAGGNIGGPPLLPAEGAIFLTTYRIIFKGTPTDPLVGEQVVIRSFPISSLTKEKKINIQAQVDQFIQEGLQLRSCTFQLLKIAFDEEVASDSAEVFRKHLHKLRYPQHVHGTFAFTVGQSPKQAMQPKAKEKNPSLSSQQVTDMFQGLTVGVMSLGHLGHSTTTLSKNLVKNAKKTIGRQYVTRKKYTPPAWEQRSSQHFPEDNEDEISVSEEMDRSTLTPTTTIRPSEKMTINHLVERACCRDYQRLGLGTLSSSLTRSKNEPFRISTVNRMYAICRSYPGLLIVPQSIQDNTIQRISRCYRQNRFPVVCWRNSRTKAVLLRSGGLHGKGVVGLFKSQNAPTAGPSQTDSTSLEQEKYLQAVINSMPHYADAGGRNTLSGFTSAHMSSADFSDKRQPKLGSLMKQVMGGKDEGPGTISRGGLGHRARVITLSTPKCVSPKGRESPRGKWGSIRASGRMSSYALNVEIGSRLAGKDLLGAQHNGAPAEASFLRQHRASLYIIGDKSQLKGVKPDPLQHWEVVPIEVFDVRQVKASFKKLMKACVPGCPSTDPSVAYLRSLEESEWLSQIHKILQISVLVVELLDTGSSVLVSLEDGWDITTQVVSLVQLLSDPYYRTLEGFRLLVEKEWLSFGHRFSHRGAQTLAGQSSGFAPIFLQFLDCVHQIHLQFPMEFEFSLYYLKFLSYHYISNRFRTFLLDSDYERIELGLLYEEKGERKCQQVYKSIWDYIDRLNKKAPVFFNYMYAPEDGEVLRPYSNISNLKVWDYYTEETLSEGPSYDWELVQGQPEHMEEADRQDTGAPQTKRKIIWPCYDNRSRMEPDAISKLLEDLHNLEMELGQVPERWKDTWDKIKASQRTEARQEGSRTPSSLLMSSGLSHHRRSLGVYLQESGVGSTLNLSLDSDTSSTSTPSSGKQGGRRSTSTLYSQFQMSESENRSYEGSLYKKGAFMKPWKPRWFVLDKTKHQLRYYDSRMDTECKGVIDLAEVESITPGTPTMGAPKTVDEKAFFDLKTTKRVYNFCAQDVQLAQQWIDRIQSCLSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SLB6</accession>
    <name>A0A8C2SLB6_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Caspase 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">CASP9</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase C14A family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SLB6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005000959.1">
        <property type="protein sequence ID" value="ENSCJPP00005000526.1"/>
        <property type="gene ID" value="ENSCJPG00005000611.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159698"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043293">
        <property type="term" value="C:apoptosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008303">
        <property type="term" value="C:caspase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071549">
        <property type="term" value="P:cellular response to dexamethasone stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034644">
        <property type="term" value="P:cellular response to UV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904019">
        <property type="term" value="P:epithelial cell apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:fibroblast apoptotic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008630">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to DNA damage"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051402">
        <property type="term" value="P:neuron apoptotic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900119">
        <property type="term" value="P:positive regulation of execution phase of apoptosis"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043525">
        <property type="term" value="P:positive regulation of neuron apoptotic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042770">
        <property type="term" value="P:signal transduction in response to DNA damage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd08326">
        <property type="entry name" value="CARD_CASP9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00032">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1460:FF:000012">
        <property type="entry name" value="Caspase 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001315">
        <property type="entry name" value="CARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042147">
        <property type="entry name" value="CARD_CASP9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033139">
        <property type="entry name" value="Caspase_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016129">
        <property type="entry name" value="Caspase_his_AS"/>
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    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002398">
        <property type="entry name" value="Pept_C14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002138">
        <property type="entry name" value="Pept_C14_p10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001309">
        <property type="entry name" value="Pept_C14_p20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015917">
        <property type="entry name" value="Pept_C14A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10454">
        <property type="entry name" value="CASPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10454:SF157">
        <property type="entry name" value="CASPASE-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00619">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038001">
        <property type="entry name" value="Caspase_ICE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00376">
        <property type="entry name" value="IL1BCENZYME"/>
    </dbReference>
    <dbReference type="SMART" id="SM00114">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00115">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50209">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01122">
        <property type="entry name" value="CASPASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01121">
        <property type="entry name" value="CASPASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50207">
        <property type="entry name" value="CASPASE_P10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50208">
        <property type="entry name" value="CASPASE_P20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="CARD" evidence="10">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Caspase family p20" evidence="9">
        <location>
            <begin position="127"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Caspase family p10" evidence="8">
        <location>
            <begin position="299"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR038001-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005000526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="376" mass="41976" checksum="C0CE6FAD0B7293C2" modified="2022-01-19" version="1">MEEARRSALRRGRLRLVEGLRPDVLWGPLRERGVFTSAMVEDMQSAGTRREQARQLVIDLESRGKQAFPIFLSILRDTGHGDLADMLDEGCGSPMSPPVDLRPVQLELPGERPPLVACQVYQLRADPCGHCLIFNNVSFSPDSNLSPRAGSDIDCEKLEKRFRSLCFNVQTLRNLKAQEIDLELRKLARLDHSALDCCLVVILSHGCQTSHIQFPGGIYGTDGKTIPIEKIVNYFNGSQCPSLRGKPKLFFIQACGGEQKDQGFEVDFESPRDETCQGSIESDAIPFQAPSGSVDELDAVASLPTPGDILVSYSTFPGFVSWRDRVSGSWYVETLDSVLECYASSEDLLTMLVRVNVFFFLHKPYFFCSVRKQGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SN62</accession>
    <name>A0A8C2SN62_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cellular repressor of E1A stimulateds 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">CREG2</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CREG family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SN62"/>
    <dbReference type="Ensembl" id="ENSCJPT00005002149.1">
        <property type="protein sequence ID" value="ENSCJPP00005001255.1"/>
        <property type="gene ID" value="ENSCJPG00005001319.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000005914"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.110.10:FF:000004">
        <property type="entry name" value="Cellular repressor of E1A-stimulated genes 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055343">
        <property type="entry name" value="CREG_beta-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13343">
        <property type="entry name" value="CREG1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13343:SF15">
        <property type="entry name" value="PROTEIN CREG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13883">
        <property type="entry name" value="CREG_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="CREG-like beta-barrel" evidence="7">
        <location>
            <begin position="198"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005001255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="365" mass="39504" checksum="91F87DD61AFF51E7" modified="2022-01-19" version="1">MALGSISTHIQGGTTRALSPRRVGLSERSRDGGRPALSLPLSPSSQRLIPVSRCSFGSLRVTDRPGGRCGRPRGAALAAIGRGRVLRAAPQKMSALWCWWLPALLWGTTGGYVVLSSVSWPLPEEGGAADELHSSSTEEALPGLLEEAGGLWKQSFPASAYREDAALGSGAAARRSEQGAAPSRMFSYRRQPAAPPGRAAIARRIARHGAWGFVASRAAHGKIQGMPYGNLLPISDGPVNNSTGIPFFYVTLKDNAVADLLKDPVASLTLPESDGNFCRKNVVDPEDPRCARLTLTGQMVTVPPEETEFAKQAMFSRHPVIRKWPRSYEWFFMKMNIEHVWLQSWYGGVSTIAVEEYLKAVPSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SP72</accession>
    <name>A0A8C2SP72_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Spermatosis associated 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">SPATA13</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015707581.2">
        <property type="nucleotide sequence ID" value="XM_015852095.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005001946.1">
        <property type="protein sequence ID" value="ENSCJPP00005001133.1"/>
        <property type="gene ID" value="ENSCJPG00005001193.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107308300"/>
    <dbReference type="CTD" id="221178"/>
    <dbReference type="GeneTree" id="ENSGT00940000154103"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030175">
        <property type="term" value="C:filopodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032587">
        <property type="term" value="C:ruffle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
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        <location>
            <begin position="846"/>
            <end position="905"/>
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            <end position="1123"/>
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            <end position="442"/>
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    <sequence length="1353" mass="152158" checksum="6A0A651F26013C77" modified="2022-01-19" version="1">MEQTFCQSSAEALHCVHRAEDFVFLKVKIWAVQPEELNSAGERGSKRSLSATDVGQAARAAAGDGNVAVSCPSLQLHAIEGMTTFQNGYGNSNAIACIVMDNKEPPNLTTSVSHNGGYSTSGCCEEETQDEKISPSKIMRFFSTPRKRANSSSDRPRSLILMGNSSTWNALSSIRKMGSFKKLKSSVLQGIQAKECPDILNENGVGKHNSNGAVVRVQTNRFSYSGPMQDFQSAVDGLVSDCSDAEEGDESFLRNTHRSRSIRRAYGAGRINLLDTDKAQSHHNGTRATSPVLAEPKICEILVKDSENNRIIYRRSKSSDNLNFLKKSSFKRKSTSNLTDLKAANEKQMPARTVSVTSADSDKTNGNPERRSKRWKSPIRAKDFDRVLKLVSNVTDVAWKKDGSKSTAPSPSEPSQRTRSNSRLHDDYSRRVSSSTDHDRKRCTSSASSLDSSSPGTPCLQSPVAAQDKEAEMDVARAEDKNLSTSSGIAESDLLSPTLSDIGPFPNEVFDTDSDEPKASQQFACDAEHPHIPVRPTAPKPQSPSTEKMMCNMDFQCSNHHSTLSLSSTESEERGEVGPKLSRNPVCFQDTVQTVYYDDGNEDSGISSHSQLSLNLAPGAEEKKEEVVSDDHWKKSSSQDEEKTDTQRVTPRRWGSGKRSRPRPLSDYGQMSIRSISIPEDSVAVESQKTDCMDGENQPGLAPVGSVIQSNTVGYSRGRKRRPISVIGGVNFYGSGPAEEIEGLLTQPTTRPPVPAHQVPPYKAVSARFRPLTFSQSTPIGLDRVGRRRQMRTSNAAADGGTESSALVDDNGSEEDYSYEEICQATPRYLQPGGEQLAINELISDGSIVYAEALWDHVTMDDQELGFKAGDVIRVLEASNKDWWWGRNEDKEAWFPASFVRLRVNQEELPENCSSIQDEEQDADISKHRQKIAENKDQMRTNVIQEIMNTERVYIKHLKDICEGYIRQCRKHTGMFTTAQLSTIFGNIEDIYKFQRKFLKDLEKQYNKEEPHLSEIGSCFLQHQEGFAIYSEYCNNHPSACIELSKLMKQGKYRHFFEACRLLQQMIDIAIDGFLLTPVQKICKYPLQLAELLKYTTQEHSDYNNIKAAYEAMKNVACLINERKRRLESIDKIARWQVSIVDWEGPDVLARSSELIHSGELTKISKQGKSQQRTFFLFDHQLVFCKKDLLRRDILYYKDRIDMDEMELVDAEDGRDKDFNINVKNAFKIINRATEEVHLFCAKKQEDKKRWMEACESERRRVQEDKEMGMEISENQKKQAMQNARKSRHGKMKGVSYNGCPVPPLHQSLHPIHQRHITVPTSIPQQQVFALAEPKRKPSLFWHTFNKLTPFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SP73</accession>
    <name>A0A8C2SP73_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Delayed-rectifier potassium channel regulatory subunit KCNS2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Delayed-rectifier K(+) channel alpha subunit 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Delayed-rectifier potassium channel subunit Kv9.2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Potassium voltage-gated channel subfamily S member 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">KCNS2</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Potassium channel regulatory subunit that modulate the delayed rectifier voltage-gated potassium channel activity of KCNB1 and KCNB2 by altering their kinetics, expression levels, and shifting the half-inactivation potential to more polarized values. While it does not form functional channels on its own, it can form functional heterotetrameric channels with KCNB1 and KCNB2. Each regulatory subunit has unique regulatory properties that can lead to extensive inhibition, significant changes in kinetics, and/or substantial shifts in the voltage dependencies of the inactivation process.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Heterotetramer with KCNB1 and KCNB2. Does not form homomultimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the potassium channel family. S (TC 1.A.1.2) subfamily. Kv9.2/KCNS2 sub-subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SP73"/>
    <dbReference type="Ensembl" id="ENSCJPT00005001164.1">
        <property type="protein sequence ID" value="ENSCJPP00005000659.1"/>
        <property type="gene ID" value="ENSCJPG00005000740.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160344"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015459">
        <property type="term" value="F:potassium channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901379">
        <property type="term" value="P:regulation of potassium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd18427">
        <property type="entry name" value="BTB_POZ_KCNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000005">
        <property type="entry name" value="potassium voltage-gated channel subfamily G member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000029">
        <property type="entry name" value="Potassium voltage-gated channel subfamily S member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000029">
        <property type="entry name" value="potassium voltage-gated channel subfamily S member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
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        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003968">
        <property type="entry name" value="K_chnl_volt-dep_Kv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003971">
        <property type="entry name" value="K_chnl_volt-dep_Kv5/Kv9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF60">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY S MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01494">
        <property type="entry name" value="KV9CHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01491">
        <property type="entry name" value="KVCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="22">
        <location>
            <begin position="17"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="465"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="465"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="477"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00061446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00065612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00070342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00077017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00080555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00082876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005000659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="486" mass="55279" checksum="1E43543A73F8C5F4" modified="2022-01-19" version="1">MTGQSLKALSEANFEDNEISINVGGFKKKMRSNTLLRFPETRLGKLLSCHSKESILELCDDYDDTKNEFYFDRNPELFPYVLHFYNTGKLHVMGELCVFSFSQEIEYWGINEFFIDSCCSYSYHGRKMEPDQEKWEEQSDQESTTSSFDEILAFYNDASKFDKQPFGNIRRQLWLALDNPGYSVLSRIFSVLSIMVVLGSIVTMCLNSLSDFQIIDSSGTPEEDPRFEIVEHFGIAWFTFELVARFAVAPDFLKFFQHALNLIDLMSILPFYITLIVNLVVESSPTLANLGRVAQVLRLMRIFRILKLARHSTGLRSLGATLKYSYREVGLLLLYLSVGISIFSVVAYTIEKEENEGLATIPACWWWATVSMTTVGYGDVVPGSTAGKLTASACILAGILVVVLPITLIFNKFSHFYRRQKQLESAMRSCDFGDGMKEVPSVNLRDYYAYKVKSLMASLTNMSRSTQIGNQKQKPGSKKEQELHVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SQF2</accession>
    <name>A0A8C2SQF2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoribosylformylglycinamidine synthase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SQF2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005004091.1">
        <property type="protein sequence ID" value="ENSCJPP00005002261.1"/>
        <property type="gene ID" value="ENSCJPG00005002464.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000007600"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10099">
        <property type="entry name" value="PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10099:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13507">
        <property type="entry name" value="GATase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01211">
        <property type="entry name" value="GATase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005002261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="89" mass="10023" checksum="13DFF24591DC9E16" modified="2022-01-19" version="1">MEAGLTPLLYVDDGGRPTQRYPMNPNGSPGGVAAILSPCGRHLAVMPHPERGVLRWQWGYWPHKWGGRWGAAPWLKMFLNAREWCEGQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SR79</accession>
    <name>A0A8C2SR79_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycosyltransferase family 92 protein</fullName>
            <ecNumber evidence="8">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC107307914</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyltransferase 92 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2SR79"/>
    <dbReference type="Ensembl" id="ENSCJPT00005001481.1">
        <property type="protein sequence ID" value="ENSCJPP00005000843.1"/>
        <property type="gene ID" value="ENSCJPG00005000925.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000064359"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008166">
        <property type="entry name" value="Glyco_transf_92"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461:SF69">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01697">
        <property type="entry name" value="Glyco_transf_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005000843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="255" mass="29929" checksum="249CC545F6DDB124" modified="2022-01-19" version="1">MFGNYNNVLQFIQSMEMYRILGVQKVMIYKNNCSQMMEKVLKFYLEEGTVEVIPWPINSYLKVSSKWRFMQDETHIGYYGQITALNDCIYRNMWRSRFVVLNDADEIILPLKHSDWKTMMSSLQEQNPGSGVFLFENHIFPTTVSTPMFNISTWNTVPGINILQHVHREPDRKEVINPKKMIVDPRKVIQTSVHSVLQAYGTSVNVPMDVALVYHCRVPLQRNLPRESLIRDTTLWRYNSSLLMNVNRVLYQTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SSK3</accession>
    <name>A0A8C2SSK3_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">CDP-diacylglycerol--inositol 3-phosphatidyltransferase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SSK3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005003645.1">
        <property type="protein sequence ID" value="ENSCJPP00005002028.1"/>
        <property type="gene ID" value="ENSCJPG00005002190.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154169"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003881">
        <property type="term" value="F:CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006661">
        <property type="term" value="P:phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362:SF4">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--INOSITOL 3-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034433985" description="CDP-diacylglycerol--inositol 3-phosphatidyltransferase" evidence="12">
        <location>
            <begin position="30"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005002028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="231" mass="24683" checksum="2E2F8689F2F80555" modified="2022-01-19" version="1">MGLPHISGYIRVVLSAVSFLLMPHSPVPAAVCYGLSAALDAVDGLAARWLNQGSRLGAMLDMLTDRCSLLCLQLNLALLYPMAAPVLQLSLCLDVASHWLHMHTWAGLRGRLSLPGNPTARDLWVLLCALWFYGVSMGLYVSLGTLIGASYGVYGSLWAVYGALWGSMGLYGALWVSMVLNVSLWASMCLSGALSGTMGLYGVSMGHNGVLWGSMGSLWGSYGDLWVSMCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2STA7</accession>
    <name>A0A8C2STA7_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SRC kinase signaling inhibitor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">SRCIN1</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2STA7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005003832.1">
        <property type="protein sequence ID" value="ENSCJPP00005002145.1"/>
        <property type="gene ID" value="ENSCJPG00005002304.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157961"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098974">
        <property type="term" value="P:postsynaptic actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030334">
        <property type="term" value="P:regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061001">
        <property type="term" value="P:regulation of dendritic spine morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034446">
        <property type="term" value="P:substrate adhesion-dependent cell spreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1540">
        <property type="entry name" value="Actin interacting protein 3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022782">
        <property type="entry name" value="AIP3-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051825">
        <property type="entry name" value="SRCIN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22741">
        <property type="entry name" value="P140CAP/SNIP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22741:SF5">
        <property type="entry name" value="SRC KINASE SIGNALING INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03915">
        <property type="entry name" value="AIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Actin interacting protein 3-like C-terminal" evidence="4">
        <location>
            <begin position="206"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="306"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="477"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="592"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="828"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="973"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1164"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="653"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="307"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="498"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="605"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="846"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="887"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1028"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1057"/>
            <end position="1069"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005002145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1205" mass="133546" checksum="F2EE1CC27E199BAB" modified="2022-01-19" version="1">MLPRWAKHPMGASPRLREQDRASEPGDRRLSPLLLDPDRTSAHMISADDAEYPREYRTLGNGTRRFSNVGLVHTSERRHTVIAAQSLEALTGLQKSEMERKRDAFMDHLKNKYPQHALALRGQQERMRDQQPNYWSFKTRSSRHSQGSQPGLADQAKLSFASAESLETMSEAELPLGFNRMNRFRQSLPLSRSTSQTKLRSPGVLFLQFGDETRRVHITHEISSMDTLHALIVHMFPQKLTMGMLKSPNTAILIKDESRNVFYELEDVRDIQDRSIIKIYRKEPLYASFPASHITNGDLRREMVYTSRESSPTRRLNNMSPAPHLASGSPPPVLQSSSPSRSRMSYSGGRPPSYAGSPVHHGERLASLPPAPGVSPSPSAILERRDVKPDEDLAGKNMVLVKNEGLYADPYGMVHEGRLSITSTQSLAGMGDPFGYSGGLYKRGSVRSLSTYSAAALQTELEDSLYKPNTQIYSDTYGPGLGFRMPPSSPQKMVEGQSPHSPYSGPPSRSSPVRQSFRKDSCSSVFMESPVSKPRNPSAAGPPELFPGPGDRPLSGFSSPVPAKDTETRERMEAMEKQIASLTGLVQSALLRGSEAETPSEKTEATNGGTPPSASTSRSGTGTPVPAPPPPSTTSTPAGQPTAITRLHMQLHLHDLQQNASDLRNQLQQLKKLQLQNQETVKTMLRRTETEISVRVTDTMRKHEDPLQRQRSLVEEERLRYLNEEELITQQLNDLEKSVEKIQKDLAHNHRLIPVQELEEKAVVLKQLGETLTDLKAQFPSLQSKMRVVLRVEVEAVKFLKEEPNRLDGLLKRCKTVTDTLTQIRRQVDEGVWTPPNNLSQSPKKMAPETDFSKGLELEMPPSPPVSLHHLTAGTEPLGMPSFGHSPPQTQSHPSKSNNPSRAPEMVPAKTQTGPETPSKKSADKAVSVEAAERDWEEKRAALTQYSAKDINRLLEETQAELMKAIPDLEFAAKHKQTTGSSSAASTPEHKPSKPQHAQKSTGKVDPNGRRGSDELTVPRYRTEKPSKSPPPPPPRRSFPSSHGLTTTRSGEVIVTSKKEPGFMKKAESEELETQKPQVKLRRTVSEVVRPASTPPIIASAIKDDDDEDRIIAELEVFQRSSASPFLPTLRYDPLTAAISPGHADMWPNGASVAAEGWKSGGVSIPPMKMVNPASRLKQSQQGSPDKSKHIKQRMEYMRIQGQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SU51</accession>
    <name>A0A8C2SU51_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prostaglandin reductase 1</fullName>
            <ecNumber evidence="4">1.3.1.48</ecNumber>
            <ecNumber evidence="5">1.3.1.74</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">15-oxoprostaglandin 13-reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Dithiolethione-inducible gene 1 protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Leukotriene B4 12-hydroxydehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">NAD(P)H-dependent alkenal/one oxidoreductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="36" type="primary">PTGR1</name>
    </gene>
    <organism evidence="36 37">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="36" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="36" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="36" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>(5S,12S)-dihydroxy-(6E,10E,12E,14Z)-eicosatetraenoate + NADP(+) = 12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51212"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:133974"/>
            <dbReference type="ChEBI" id="CHEBI:133975"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="31">
            <dbReference type="Rhea" id="RHEA:51213"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>13,14-dihydro-15-oxo-PGF2alpha + NADP(+) = 15-oxoprostaglandin F2alpha + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50588"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:133374"/>
            <dbReference type="ChEBI" id="CHEBI:133409"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="27">
            <dbReference type="Rhea" id="RHEA:50590"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="32">
            <text>13,14-dihydro-15-oxo-prostaglandin E1 + NADP(+) = 15-oxoprostaglandin E1 + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57401"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:133408"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="32">
            <dbReference type="Rhea" id="RHEA:50586"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>13,14-dihydro-15-oxo-prostaglandin F1alpha + NADP(+) = 15-oxoprostaglandin F1alpha + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50592"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:79072"/>
            <dbReference type="ChEBI" id="CHEBI:133411"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="24">
            <dbReference type="Rhea" id="RHEA:50594"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>20-hydroxy-leukotriene B4 + NADP(+) = 12-oxo-20-hydroxy-leukotriene B4 + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51208"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57460"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:133346"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="29">
            <dbReference type="Rhea" id="RHEA:51209"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>4-hydroxynonanal + NADP(+) = (E)-4-hydroxynon-2-enal + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:64736"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58968"/>
            <dbReference type="ChEBI" id="CHEBI:156112"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="28">
            <dbReference type="Rhea" id="RHEA:64738"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>6-trans-leukotriene B4 + NADP(+) = 12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51204"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:90723"/>
            <dbReference type="ChEBI" id="CHEBI:133974"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="30">
            <dbReference type="Rhea" id="RHEA:51205"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="33">
            <text>an n-alkanal + NADP(+) = an alk-2-enal + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13737"/>
            <dbReference type="ChEBI" id="CHEBI:12834"/>
            <dbReference type="ChEBI" id="CHEBI:13757"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.74"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="33">
            <dbReference type="Rhea" id="RHEA:13739"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>decanal + NADP(+) = (2E)-decenal + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50612"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:31457"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:133455"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="21">
            <dbReference type="Rhea" id="RHEA:50614"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>dodecanal + NADP(+) = (2E)-dodecenal + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50784"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:27836"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:133741"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="25">
            <dbReference type="Rhea" id="RHEA:50786"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="34">
            <text>hexanal + NADP(+) = (E)-hex-2-enal + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50776"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28913"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:88528"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="34">
            <dbReference type="Rhea" id="RHEA:50778"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>leukotriene B4 + NADP(+) = 12-oxo-leukotriene B4 + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50608"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57461"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:133309"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:50609"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>nonan-2-one + NADP(+) = (3E)-nonen-2-one + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50616"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:77927"/>
            <dbReference type="ChEBI" id="CHEBI:133457"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="26">
            <dbReference type="Rhea" id="RHEA:50618"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>octanal + NADP(+) = (2E)-octenal + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50780"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17935"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61748"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="20">
            <dbReference type="Rhea" id="RHEA:50782"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>pentan-2-one + NADP(+) = (E)-pent-3-en-2-one + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50788"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16472"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:145276"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="22">
            <dbReference type="Rhea" id="RHEA:50790"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer or homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NADP-dependent oxidoreductase L4BD family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.48" evidence="4"/>
    <dbReference type="EC" id="1.3.1.74" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2SU51"/>
    <dbReference type="Ensembl" id="ENSCJPT00005005912.1">
        <property type="protein sequence ID" value="ENSCJPP00005003291.1"/>
        <property type="gene ID" value="ENSCJPG00005003524.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154810"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome Z"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047522">
        <property type="term" value="F:15-oxoprostaglandin 13-reductase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035798">
        <property type="term" value="F:2-alkenal reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006693">
        <property type="term" value="P:prostaglandin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08294">
        <property type="entry name" value="leukotriene_B4_DH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000121">
        <property type="entry name" value="Prostaglandin reductase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014190">
        <property type="entry name" value="PTGR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205:SF7">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="15" id="KW-0379">Hydroxylation</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0644">Prostaglandin metabolism</keyword>
    <keyword evidence="37" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="35">
        <location>
            <begin position="15"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00032255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00032297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00033119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00047871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00047878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00047903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00048066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00048290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00048387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00048591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00048953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00049068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00049070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="ARBA" id="ARBA00049179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="ARBA" id="ARBA00049368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="35">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="36">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005003291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="37">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="330" mass="36051" checksum="0F5EC24188598C05" modified="2022-01-19" version="1">MVTAKVWVLKKHFEGFPKTSDFEMKEVALANLKDGEMLLESVFLSVDPYMRPYSKRDMKEGDVMIGTQIASRIVESKNPAFAVGAFVVANSGWRTHFISDGRGLNLLPSSWPESLPKSLALGTIGMPGLTAYFGLFEVCKMKPGETVLVNAAAGAVGSVVGQLAKIGGCKVVGCAGSDSKVAYLKKIGFDEAFNYKTVSSLDEALRKASPDGYDCFFDNVGGEFASIAINQMKKYGRIAVCGAISQYNDSVPQKGPYVQFPMIFKELSMKGFIVSSWSNRREEGVKALLKWVLEGKLKYHEQVTERFENMPAAFIGMLKGENLGKAIVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SUE2</accession>
    <name>A0A8C2SUE2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">AT-rich interactive domain-containing protein 4B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">180 kDa Sin3-associated polypeptide</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Histone deacetylase complex subunit SAP180</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">ARID4B</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the Sin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes. Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4A. Involved in spermatogenesis, together with ARID4A, where it functions as a transcriptional coactivator for AR (androgen receptor) and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier. Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of a Sin3A corepressor complex consisting of SIN3A, SAP130, SUDS3/SAP45, SAP180, HDAC1 and HDAC2. Interacts with ARID4A. Interacts with AR.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSCJPT00005005521.1">
        <property type="protein sequence ID" value="ENSCJPP00005003055.1"/>
        <property type="gene ID" value="ENSCJPG00005001975.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158149"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SXP5</accession>
    <name>A0A8C2SXP5_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Butyrophilin subfamily 3 member A3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC107325881</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
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        <property type="nucleotide sequence ID" value="XM_015887121.2"/>
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        <property type="protein sequence ID" value="ENSCJPP00005004842.1"/>
        <property type="gene ID" value="ENSCJPG00005004700.1"/>
    </dbReference>
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        <property type="component" value="Chromosome LGE64"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
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        <property type="entry name" value="B30.2/SPRY_sf"/>
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        <property type="entry name" value="BTN3A2-like_Ig-C"/>
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    <dbReference type="InterPro" id="IPR003879">
        <property type="entry name" value="Butyrophylin_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
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        <property type="entry name" value="Ig-like_dom"/>
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        <property type="entry name" value="Ig-like_fold"/>
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        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
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        <property type="entry name" value="TRIM/RBCC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24103">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22705">
        <property type="entry name" value="C2-set_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01407">
        <property type="entry name" value="BUTYPHLNCDUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034514248" evidence="9">
        <location>
            <begin position="22"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="34"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="10">
        <location>
            <begin position="179"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="150"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005004842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="377" mass="42460" checksum="2C9D438D3BC594D9" modified="2022-01-19" version="1">MELTSAIFIFVLASIHQPIAGVGHDPLLVVDDYEGGGIRLKCLSERLFSEAQLLWMDSRGDNITGTPLPVDTSTVSISSSIILKAGSRNSVSCRIIDKQLKTSTESSVAIADAFFPSTSPWLAAFVLILLLSIFLVLAAMYKMRNNNKEVTRAQNTRKQIQEEEQKRRFEKENEDAKGKIENVRNELKFRKARRNAVNITLDQKCKHPNLCISDDKRRVKSSDKTETVLKAMVVATEGFPSKKHYWEVEVGNQSQWELGVVSEKIRNMIMNNTENSLPANNVFSLQYSQGTYTFSDGQDIRDCEQCSVVGVLLDMENTELSFYDAEEMRPLGTVFFECTGNIYPFFSPDSSGNWLGVRPVKPQTYEALPQSDKEINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SXR3</accession>
    <name>A0A8C2SXR3_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Interleukin-2 receptor subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC107315066</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015720652.1">
        <property type="nucleotide sequence ID" value="XM_015865166.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SXR3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005007013.1">
        <property type="protein sequence ID" value="ENSCJPP00005004116.1"/>
        <property type="gene ID" value="ENSCJPG00005004164.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107315066"/>
    <dbReference type="GeneTree" id="ENSGT00390000018872"/>
    <dbReference type="OrthoDB" id="9944172at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019976">
        <property type="term" value="F:interleukin-2 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004911">
        <property type="term" value="F:interleukin-2 receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002376">
        <property type="term" value="P:immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015486">
        <property type="entry name" value="IL-2_rcpt_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10573">
        <property type="entry name" value="INTERLEUKIN-2 RECEPTOR ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10573:SF0">
        <property type="entry name" value="INTERLEUKIN-2 RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0391">Immunity</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 15" id="KW-0732">Signal</keyword>
    <keyword evidence="14" id="KW-0768">Sushi</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034195804" description="Interleukin-2 receptor subunit alpha" evidence="15">
        <location>
            <begin position="21"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="16">
        <location>
            <begin position="21"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="16">
        <location>
            <begin position="119"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="121"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005004116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="211" mass="23703" checksum="1CFE2C1977395890" modified="2022-01-19" version="1">MELKRLLMWLLLGSIMGTRAEKCPRLSTTEFADLAAEAYPLKTKLRYECDSGYRRRSGNSLMIRCQNISGTASWVYDELVCIDEKLLFSRNHTDKLNSIQEPARETQSPAPPKQVNNSSFCGVPKTVPHTSLSAHQQYSVGQVLHFKCPTAYNKQLPFSGTITCKNVDGSIKWTPLDKPCTNDSCPTNKHLSHLIEAVIFFILPLHSAVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SZ13</accession>
    <name>A0A8C2SZ13_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SKI family transcriptional corepressor 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">SKOR2</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKI family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015703722.1">
        <property type="nucleotide sequence ID" value="XM_015848236.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032297324.1">
        <property type="nucleotide sequence ID" value="XM_032441433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SZ13"/>
    <dbReference type="Ensembl" id="ENSCJPT00005008358.1">
        <property type="protein sequence ID" value="ENSCJPP00005005099.1"/>
        <property type="gene ID" value="ENSCJPG00005004937.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005008360.1">
        <property type="protein sequence ID" value="ENSCJPP00005005101.1"/>
        <property type="gene ID" value="ENSCJPG00005004937.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107305722"/>
    <dbReference type="KEGG" id="cjo:107305722"/>
    <dbReference type="CTD" id="652991"/>
    <dbReference type="GeneTree" id="ENSGT00940000160474"/>
    <dbReference type="OrthoDB" id="3938623at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome Z"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042826">
        <property type="term" value="F:histone deacetylase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046332">
        <property type="term" value="F:SMAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021702">
        <property type="term" value="P:cerebellar Purkinje cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030514">
        <property type="term" value="P:negative regulation of BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030512">
        <property type="term" value="P:negative regulation of transforming growth factor beta receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045880">
        <property type="term" value="P:positive regulation of smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021936">
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        <property type="project" value="Ensembl"/>
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    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="145"/>
            <end position="237"/>
        </location>
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        <location>
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        <location>
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        <location>
            <begin position="453"/>
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        </location>
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        <location>
            <begin position="505"/>
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    </evidence>
    <sequence length="823" mass="88994" checksum="61222F6E4B6DB743" modified="2022-01-19" version="1">MATSPLPAPTDILLPSPSGTYPPDPMNQQQRAGHAAMKPNQVGQVILYGIPIVSLVIDGQERLCLAQISNTLLKNFSYNEIHNRRVALGITCVQCTPVQLEILRRAGAMPISSRRCGMITKREAERLCKSFLGENRPPKLPDNFAFDVSHECAWGCRGSFIPARYNSSRAKCIKCTYCSMYFSPNKFIFHSHRTPDAKYTQPDAANFNSWRRHLKLTDKSPQDELVFAWEDVKAMFNGGSRKRALPPTPTATTPGTTAVPQCHALGSVKAAAVVGGGLLAPHLLAAAPQELQQKRPRFEEDEELHEAVAVAGGKSPRSYPLIPVPSKGAFGGVLQKFPGCGGLFPHPYGFPAAFGLCHKKEEGSSAGDALGGTAAHKAGGGTAGGGGLSGLFWPGRKDAAFYPPFCMFWPPRTPGALPVPTYLQPPPQPPGATLGCALGDGALRQAFLDLSEPEAAASEPASPSASDGGNGASGARVPPHPMEAAGGHKAARGGYHHSSAFRPVGGKEDSESLAKLHGGGPHRPASPLQLLLPPPPPPPPPPPPPPEDGGCERPPYPPAGTFASEDSSEEEEEEEEEEEDEPEVDVEGHKPPDEEEEEDEEDEEEEGEEDTDPLTPTTRFPPSRALPEKAGQDRPTTTSHPFARPPAEEKLGEGQAPRAGSGGSSPVQHLALEEPPCYKDNQKSKEGNQVVLPTKEDNFSDKSKEHNFFITDSEPSGGDFWRDVAGEHTQETNSPHSLKKDVENMGKEELQKVLFEQIDLRRRLEQEFQVLKGNASFPVFNNFQDQMKRELAYREEMVQQLQIIPYAASLIRKEKLGAHLSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SZL2</accession>
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        <submittedName>
            <fullName evidence="4">C-X-C motif chemokine ligand 14</fullName>
        </submittedName>
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        <name evidence="4" type="primary">CXCL14</name>
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        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
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        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:inner ear development"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:negative regulation of myoblast differentiation"/>
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        <property type="term" value="P:positive regulation of natural killer cell chemotaxis"/>
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        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
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        <location>
            <begin position="23"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Chemokine interleukin-8-like" evidence="3">
        <location>
            <begin position="24"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005005390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="98" mass="11612" checksum="C1D99E451AADCEF1" modified="2022-01-19" version="1">MKLLTAALLLLFIAMCLASAEGVKCKCSRKGPKIRFSNVRKLEIKPRYPFCVEEMIIVTLWTKVRGEQQHCLNPKRQNTVRLLKWYRVWKEKGRVYEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SZP2</accession>
    <name>A0A8C2SZP2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Heterogeneous nuclear ribonucleoprotein A0</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">HNRNPA0</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
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            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">mRNA-binding component of ribonucleosomes. Specifically binds AU-rich element (ARE)-containing mRNAs. Involved in post-transcriptional regulation of cytokines mRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015731182.1">
        <property type="nucleotide sequence ID" value="XM_015875696.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SZP2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005008818.1">
        <property type="protein sequence ID" value="ENSCJPP00005005426.1"/>
        <property type="gene ID" value="ENSCJPG00005005201.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107320132"/>
    <dbReference type="KEGG" id="cjo:107320132"/>
    <dbReference type="CTD" id="10949"/>
    <dbReference type="GeneTree" id="ENSGT00940000154808"/>
    <dbReference type="OrthoDB" id="1875751at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12326">
        <property type="entry name" value="RRM1_hnRNPA0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12579">
        <property type="entry name" value="RRM2_hnRNPA0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000581">
        <property type="entry name" value="Heterogeneous nuclear ribonucleoprotein A0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000040">
        <property type="entry name" value="Heterogeneous nuclear ribonucleoprotein A2/B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034801">
        <property type="entry name" value="hnRNPA0_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48026:SF28">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN A0,-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48026">
        <property type="entry name" value="HOMOLOGOUS TO DROSOPHILA SQD (SQUID) PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="RRM" evidence="15">
        <location>
            <begin position="7"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="15">
        <location>
            <begin position="98"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="169"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="169"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00056839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00067976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005005426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="307" mass="30798" checksum="88D4A2064A1B086C" modified="2022-01-19" version="1">MENSQLCKLFIGGLNVQTTEAGLREHFAAYGTLTDCVVVLNPQTKRSRCFGFVTYSAVEEADAAMAASPHAVDGNSVELKRAVSREDSAKPGAHAKVKKLFVGGLKGDVGEGDLVQHFSQFGPVEKAEIIADKQSGKKRGFGFVYFQNHDAADKAAVVKFHPIQGHRVEVKKAVPKEDIQAGGGGSARPSRGGRGGGRGRGGGSGNRDHNGLSKGGGGGYNSYGGYGGGGGGGYGGYGGGSYGGGGGGGDYGNGYGGFGTYSQHQSAYGPMKSGGGGGGGGGNWGGRSNSGPYRGGYGGGGYGGGSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T015</accession>
    <name>A0A8C2T015_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">USP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T015"/>
    <dbReference type="Ensembl" id="ENSCJPT00005007608.1">
        <property type="protein sequence ID" value="ENSCJPP00005004567.1"/>
        <property type="gene ID" value="ENSCJPG00005004498.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160942"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF660">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="2">
        <location>
            <begin position="24"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005004567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="428" mass="48049" checksum="8C64AC768E27F831" modified="2022-01-19" version="1">MSGQTNRASWRSGLLPGCSLHWHCASHNANCPSCFASAVVFCSFQHSVLNLTEGSSQPLMTKLQSLFAFLEHSQQPAISPESFLSASQPFWFTPGSQQDCSEYLKYLLNRYVASMEEIGPQFIESPKKQPTGSAWIRRKPAVSGDPGAQPVLMEILGLQEPREPAHTTRDADWASGEQTRAPKESRSLGDLINNFLSPERLTAENQYHCKKCASLQDAEKVAELTEAPHYLILTLLRFSFDPKTMKRTKILDNVSIPEVLKLSDLGSTFVSTVYDLCSVVVHSGITSESGHYYCFCRECTDTVPNTQPRDGTPKLASNKQLDSEIPWYLFNDHRVCTCSFETISNLTSLFPSATAYMLFYRQRAERPTGPSLSKDLMEAISKDNILYLQEQEKGARNRAVYISTLPTSPLWWRDSIRRQFLIQHSAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T0H7</accession>
    <name>A0A8C2T0H7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T0H7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005008566.1">
        <property type="protein sequence ID" value="ENSCJPP00005005239.1"/>
        <property type="gene ID" value="ENSCJPG00005005058.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286972"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15225">
        <property type="entry name" value="7tmA_OR10A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000001">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26453">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0552">Olfaction</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="22"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="40"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005005239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="307" mass="34718" checksum="E1FADE45DFD1CCA6" modified="2022-01-19" version="1">MEYCNHTVGPGFLLDFSDPPGLPGLCFTIFLLIYVTVIIGNSLIVLVTVLDLSLRSPMYFFLRNLSFLEICYTSATLPKILMCFLTGDVRISFLGCAAQLYFLVLLGSTECLLLASMAYDRYVAICDPLHYSLLMNGGFCVRLVVGSWMVAVPIQVGQTYQVFTLPFCASHHLHHFFCDVPPLLELACADTFWSWVTLHTIILLFVVLPFFMIVVSYVRIIKTVLKMHSAPSRHKAFSTCSSHLIVLTLFFGSATVAYFKHHSKDSADTDKYLALFYTILTPMFNPVIYGMRNREVRIALRKLLWGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T0J8</accession>
    <name>A0A8C2T0J8_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Synapse</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complexin/synaphin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T0J8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005010369.1">
        <property type="protein sequence ID" value="ENSCJPP00005006595.1"/>
        <property type="gene ID" value="ENSCJPG00005006157.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000287510"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043195">
        <property type="term" value="C:terminal bouton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046928">
        <property type="term" value="P:regulation of neurotransmitter secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016079">
        <property type="term" value="P:synaptic vesicle exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22809">
        <property type="entry name" value="Complexin_NTD_CPLX_III_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008849">
        <property type="entry name" value="Synaphin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16705">
        <property type="entry name" value="COMPLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16705:SF12">
        <property type="entry name" value="COMPLEXIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05835">
        <property type="entry name" value="Synaphin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="4" id="KW-0532">Neurotransmitter transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0770">Synapse</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="13"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="109" mass="12097" checksum="348B482E6E07931B" modified="2022-01-19" version="1">MAAFFTAALRNLRGGEEEPKAAPKDGKAATLPNGMSREEFEEYQRQLLEEKIERDKAFAHRKAERATVRMHLRDKYHLPCSAPPCSVLCPPLVPAFSPHTCPSLSGPHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T389</accession>
    <name>A0A8C2T389_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">B-cell differentiation antigen CD72-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC107305761</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T389"/>
    <dbReference type="Ensembl" id="ENSCJPT00005010616.1">
        <property type="protein sequence ID" value="ENSCJPP00005006808.1"/>
        <property type="gene ID" value="ENSCJPG00005006293.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000003668"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome Z"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039689">
        <property type="entry name" value="CD72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15028:SF6">
        <property type="entry name" value="B-CELL DIFFERENTIATION ANTIGEN CD72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15028">
        <property type="entry name" value="CD72-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="220"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="340" mass="38585" checksum="8EDE1EBCCD807E88" modified="2022-01-19" version="1">MAQPTRCWRQPAWMTQTAPMRMLYRDRHLWGRQGKGLKAAQVSAQRGTGMGTGMGTGAPLPPRSVGDSWLLVCLAGHWSWRRCVPVGLLAAVLLLSVALVALGTCYWQVTHQLQNVTMEQATERDHFAKEEQVWEQSLKQTQQELAWVQEELQQAWQEARNRQQELASREAELVHVSGTLNATQKELQDVQGKLRASKEAASSLRVCLNADCCPSGWLLYRGKCLFISAMKKSWWDSYWDCKEKSSQLLVLGQWESLVLPNFLQTDGAKYWIGGIYKRSSEIQWLDKKPYSQEEWFNYCGATANGKIEKKWCADAHAWICEQAPDMSSVSESIFPLLAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T4D4</accession>
    <name>A0A8C2T4D4_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Upstream-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">UBP1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the grh/CP2 family. CP2 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T4D4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005009680.1">
        <property type="protein sequence ID" value="ENSCJPP00005006109.1"/>
        <property type="gene ID" value="ENSCJPG00005005738.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156148"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001525">
        <property type="term" value="P:angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032897">
        <property type="term" value="P:negative regulation of viral transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd09588">
        <property type="entry name" value="SAM_LBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000036">
        <property type="entry name" value="upstream-binding protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007604">
        <property type="entry name" value="CP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057520">
        <property type="entry name" value="GRHL1/CP2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041418">
        <property type="entry name" value="SAM_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040167">
        <property type="entry name" value="TF_CP2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037600">
        <property type="entry name" value="Ubp1_SAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11037">
        <property type="entry name" value="TRANSCRIPTION FACTOR CP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11037:SF13">
        <property type="entry name" value="UPSTREAM-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04516">
        <property type="entry name" value="CP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25416">
        <property type="entry name" value="GRHL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18016">
        <property type="entry name" value="SAM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51968">
        <property type="entry name" value="GRH_CP2_DB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Grh/CP2 DB" evidence="11">
        <location>
            <begin position="24"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="200"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="249"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="280"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="316"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00067531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="501" mass="56711" checksum="6F5A1D11EB9259CE" modified="2022-01-19" version="1">MSDVLALPIFKQEDSSLPPENEAQHPPFQYVMCAATSPAVKLYDETLTYLNQGQSYEIRMLDNRKAGDIPEINGKLVKSIIRVVFHDRRLQYTEHQQLEGWKWNRPGDRLLDLDIPMSVGVIDIKTNPSQLNAVEFLWDPTKCTSAFIQVHCISTEFTPRKHGGEKGVPFRIQVDTFKQTENGEYTDHLHSASCQIKVFKPKGADRKQKTDREKMEKKTTQEKEKYQPSYETTILTEMRLEPIIEDAVEHEQKKSSKRTLPADYGDSLAKRGSCSPWPDTPTTFVNNSPTPAPTFTSAQHNTYSVPDSNSSSPNHQGDGTSQGSGDQLHPSATIQETQQWLLKHRFSTYTRLFSNFSGADLLKLTREDLVQICGPADGIRLYNALKSRSVRPRLTIYVCQEPVRSIQLERQDAGNGDSSNGAIYVYHAIYLEEMAASEVTRKLALAFNIPLHQINQVYRQGPTGIHILVSDQMVQNFQDESCFLFTTIKAENGEGFHIILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T5J6</accession>
    <name>A0A8C2T5J6_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dihydrouridine synthase 4 like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">DUS4L</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T5J6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005011390.1">
        <property type="protein sequence ID" value="ENSCJPP00005007338.1"/>
        <property type="gene ID" value="ENSCJPG00005006778.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00550000074907"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082">
        <property type="entry name" value="TRNA-DIHYDROURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082:SF31">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20A_20B) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="6">
        <location>
            <begin position="1"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005007338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="262" mass="29204" checksum="329F1E39ED1550FE" modified="2022-01-19" version="1">MVVAADFVRSAKARDSEFTTNRGDNPLIVQFAAKEAQVLCDAALLVCPFADGIDLNCGCPQRWAMAEGYGACLINKPELVQDMVRHVRNQIDNPRFSVSIKIRIHEDIKKTVDLCKKAEATGVSWITVHGRNIEERHQPVHYDAIKVIKESIHIPVVANGDIKTLKDAENVHHLTGADGVMVARGLLANPAMFAGYEETPLKCIQDWVDIALEHGTPFTCFHHHLMYMMERITSKQEKKVFNVLSSTSAVLDYLGHHYGVCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T5K7</accession>
    <name>A0A8C2T5K7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">TTC3</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005013311.1">
        <property type="protein sequence ID" value="ENSCJPP00005008835.1"/>
        <property type="gene ID" value="ENSCJPG00005007838.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154465"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070936">
        <property type="term" value="P:protein K48-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd16481">
        <property type="entry name" value="RING-H2_TTC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056872">
        <property type="entry name" value="TTC3/DZIP3-like_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056870">
        <property type="entry name" value="TTC3/DZIP3/RBM44-like_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043866">
        <property type="entry name" value="TTC3/DZIP3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056871">
        <property type="entry name" value="WH_TTC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17550">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TTC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17550:SF4">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TTC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24525">
        <property type="entry name" value="TTC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24905">
        <property type="entry name" value="TTC3_9th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19179">
        <property type="entry name" value="TTC3_DZIP3_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24812">
        <property type="entry name" value="WHD_TTC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="TPR" evidence="11">
        <location>
            <begin position="204"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="11">
        <location>
            <begin position="542"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="1900"/>
            <end position="1940"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="327"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1730"/>
            <end position="1757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1815"/>
            <end position="1884"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="1388"/>
            <end position="1539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="348"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="358"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="416"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1826"/>
            <end position="1840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1859"/>
            <end position="1875"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005008835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1959" mass="224485" checksum="8A417CCD151F34AA" modified="2022-01-19" version="1">MGEPLSDSEFAALAVSAGYKSCCELGHGVFVQRSPHKPKTDVDPCEVWCRQPVDKLREYCNIIKIRIFWPLLFQSESNYLVADWGSIHILDWNWKKLCDLVLVEDLVDLTKKVVNVPHFIGGILRIGSRLENGFFDVRDALDWIRCTGNINILQKLEKLGDFGWLYLETFFGGCKYYITKVALEDCNLVEEFKAVTCENCRKKSESMKQKGNEEFSQGKIDHAIVSYTKAIEFCPANHLLYGNRALCLILTKQYKRALADGKRATILKPNWPKGHYHFCKALSLLGEHELALEANERAQELCKNILDGLKDLIQQNDKLKKTLEETKGTKEYKQKPKNLHLEKKGCGSSKSHLIISQEQKEIEKDRRQMQFDHKDDHYHQKHDTTVTSMPRTENKVWSSDFPPSQSHQHKGRSKNKPGEPEKKQDHLDSKIESKTIQDKLVCTMHQVDSTMLLEVIKSLVHDGYTALMDQRCHSAEQMFSQLLNIVDPSELKQLNLRVINYVVFIYGHATSLLGIGQPEALAKAEDQFKRIIVQYQEERFDCLAYYGIGKVYLRQNRFSDALNQFMKSQTMINHKIVPGVLTWPTTSQVIEETRTENLQLFLKNCIEECRFPPEPDAVCRYQQCHGHSKIQIFFTDPDFKGFIRITCCQQCRVEFHTSCWKKLKTANYSDKNDKDFLQELCFTPDCKGLISKIVIFSSSGLVKCEFEQKITKPKEPPRAVIKQKCSSFRKLKRKEEKKLRRKRAREDALHSSKQKIEENQLQNEPCQYHNRSGYAGYAGDQVLQRIIQNAEQIKTAVRDASKLLKELLSWSVISEEDYTSYCKTSSVSHAVVEQLISYLIREENRVKTRGFIRVLSELEEVDPKLQRWMKHLNDLGLTATVNFILQYGQSLTQLDFSILSSLWNEKYGSKFDYVSSSSEGREILDYFLKPPLEKVRCFIWLLEDNRENFPSLHQALDEFFDKTDNPTIILKKHGNEDIWTNGIKVKNKSRKKNYKDPRSVLVLSSGVSTAPQEENTFIEENTLDFTYYEPCIIPEYLRRQLEEFESAYGISNIDSYQRLDDNLNQTCESLYDYFSQILEEHGPMELNNELLVGEYEHFPEEAQKIVEDEGGLKSFLLKSHRFVMVDNFISLRHDVLTKESKNRDETENNEGGNYIVCDVRENSFQNKIQLNPAAKEFEPMSYPKQPHTSTSADISLGSCETPQYLTYSLPTPWQSVLSQDIDPVENMPYFSEVLLYQDFRDESRFLPQTPWDYQCERTSPVTSPLPLLSNGAKQPGYTYADHVTHQDNDELASSDRKYVSSNFIPADIETYRDPQCLVENSDNAFYEDSFSVPNGTDKADCDIQMIKKEKESRSIPVKKNNPHTRMVAVQVNNEVTDRETNTLPFHPFEKQQGDILRMEKEHQVLKEQLKEAQEKYEQLENRSSEEINVLEELIKKIVEERGIFKKEVEWLHQALEIKVKKWQQEKKENQENLKAMRNTAKKHMDTNDRYSKTIDEKEKEYNTCLNTYLETSNKFANEKVKLEELIKKSQDDFKEHEKRAVKAEISVLQNWKESELCKLNGVVAKAEANLKMLKSLNSSSASALPDLKSQINYWEVFISNIKKQMEKVKVGYEEKIEKVKNGARNCLTKIEAVDLSSLPSVLRKQSRPAVSDPALVLYSFASAQPNSLPAVSSSADQGPVTASFNTQAGVKPANANSKVCSASDGSVKTNSKARAGSYADKVLLTSMSKVSGSNTQNIRPNQTHQDNSDTQMKPSSNNTFENIIAHLQTIFPGYSSSEFTRFIKDVQRRSGNTLSLSSTEILSRVTDLILDQQNEASTSVGRPTKSASSASAGQTGTQSQEAAAEGNVSSAPKARPAHKSTSSKNTLPSQPNLQPWGNAGATPKSKWKKIDYIPSSDDPCIICHDELSRDSCELECGHHFHRECIRKWLKEHSSTCPICRIHVLLPEDFPELPARNKYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T7I3</accession>
    <name>A0A8C2T7I3_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T7I3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005014195.1">
        <property type="protein sequence ID" value="ENSCJPP00005009514.1"/>
        <property type="gene ID" value="ENSCJPG00005008346.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005009514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="87" mass="9881" checksum="711087012327EED8" modified="2022-01-19" version="1">MCNFRSVVSMSKILSGVRISTKRIDGHVSEMEVGAVRSGFFLMHGRSLTVNLQTYDKVIRWGEEKKKACRISNLNRSESQDMSKKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T981</accession>
    <name>A0A8C2T981_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T981"/>
    <dbReference type="Ensembl" id="ENSCJPT00005014255.1">
        <property type="protein sequence ID" value="ENSCJPP00005009554.1"/>
        <property type="gene ID" value="ENSCJPG00005008381.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01110000267556"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005009554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="76" mass="8857" checksum="682E2380A0CC197E" modified="2022-01-19" version="1">YFTCNFMGRKKSATESKLFWSEVKYTGSVRYTRLDSLLIEAAMTWELTAIVLFRPAKSLPSFMVAFSVLRKRPRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T9Y0</accession>
    <name>A0A8C2T9Y0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Collectin-12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">COLEC12</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T9Y0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005015752.1">
        <property type="protein sequence ID" value="ENSCJPP00005010672.1"/>
        <property type="gene ID" value="ENSCJPG00005009259.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183074"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030169">
        <property type="term" value="F:low-density lipoprotein particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038187">
        <property type="term" value="F:pattern recognition receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005044">
        <property type="term" value="F:scavenger receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006910">
        <property type="term" value="P:phagocytosis, recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044857">
        <property type="term" value="P:plasma membrane raft organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd03590">
        <property type="entry name" value="CLECT_DC-SIGN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.100.10:FF:000017">
        <property type="entry name" value="collectin-12 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033989">
        <property type="entry name" value="CD209-like_CTLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058762">
        <property type="entry name" value="COLEC12_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26004">
        <property type="entry name" value="COLEC12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="10 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0176">Collagen</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0430">Lectin</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="18">
        <location>
            <begin position="614"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="439"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="297"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="475"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="502"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="523"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="544"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="571"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005010672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="763" mass="84190" checksum="D9E59C52DBC2338B" modified="2022-01-19" version="1">MKDDFAEEEEVQSFGYKRFGIQEGTQCTKCKNNWALKFSIILLYILCALLTITVAILGYKVVEKMDNVTGGLETSHRRYTEKLTEVESDLKKLDDQAGQKALNTNTELSSFRSDILALRQQLHDIAEKTTRNKDTLEKLQESGNVLDDRQSQMRSALDSNSFMIISVNKTLQAYTGYINNLQQDTSNIQTNLQNQVHSHNVVIMNLNNLNLTQIQQRNLISVLQKSMEDTSLAILRIKNDFQNLQQVVLQARKDTDWLKEKVQNLQTLAANNSALAKANNDTLEDMNNQLSSFSGQMENITTIAQANEQNLKDLQEQHKEYENRTSVKFNQLEERFQVFETDIVNIISNISYTAHHLRTLTSNLNEVRTTCTDTLSKHSDELIFMNSTLANIRLDSASLKMQQDLMRSRLDVEVANLSVIMEEMKLVDSKHGQLIKNFTILQGPPGPRGPKGDRGPQGPLGPAGLKGQKGEKGEPGPPGPAGEKGPPGPIGPPGEKGGKGSRGSPGSKGQRGSPGKTGLPGPSGDPGPPGPQGKDGPPGPQGPPGFQGLQGTVGEPGVPGPRGLPGLPGVPGLPGPKGPPGPPGPPGPGMPMALQSEPTSVPEANGCSPHWKNYTEKCYYFSIEREIFEEAKLFCEEKASRLVIINNKEEQQWIKRQISGKGSFWIGLTDSEKENEWRWLDGSSPLYTNWKTGQPDNWSHGHGPGEDCAGLIYAGLWNDFYCEDVNNFICEKDMDKGKQGIRFDYFTLYVAGQIQVHFAQIHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TAA9</accession>
    <name>A0A8C2TAA9_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Protein SERAC1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Serine active site-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">SERAC1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the SERAC1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TAA9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005014511.1">
        <property type="protein sequence ID" value="ENSCJPP00005009750.1"/>
        <property type="gene ID" value="ENSCJPG00005008277.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000003560"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044233">
        <property type="term" value="C:mitochondria-associated endoplasmic reticulum membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032367">
        <property type="term" value="P:intracellular cholesterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036148">
        <property type="term" value="P:phosphatidylglycerol acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF2">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005009750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="653" mass="73940" checksum="2597070BE0257A3B" modified="2022-01-19" version="1">MSVAAYCIFCCRQIGTSGPATKHHPSWNNIRKIAKVTGSLILGGFVFITYEVWSLKKLLQIDTQAIHQEKLKSHVYICTSSLNRNEYQGITYQARKEIHRAVRKILEAEAKIFRRPFNERFSTFDGEDHECALWLLLKRTQSEDKEVRLQAVQELAKNTHWHDYQYGTVAQTCDQRTAIGLARSKDIDLRFFLPPPSLPKMKNDCLIEDELRLLLVSLPQSGLDPCVKYFTSLALRESSQTLAAQRGGLWCFGGNGLPYCETLSKVPSETVELFCLQALVQHSKVSSHCDKIEAHGGLQLLQKIYQLRKDSAKIQRNIIRIIGNMALDERLHSSIVRAGWVSVLAEVMKSPHVIQSSHASRALANLDRDTVQEKYPDGVYVLHPQYRSSQPIRADILFVHGLLGAAFKTWRQQDIDQPVDKKASEVQEEYSQCWPKTWLASDCPTLRIISVEYDTRLSDWKAKCPVETSIAYRSNELLEKLRAAGIGERPLVWVSHSMGGLLVKKMLVDASKNPEMDKIVNNTRGIIFYSVPHHGSQLAEYSISARYLLFPSVEVKELSKDSPALKVLNDEFLSFAKDKKFTVLSFAETLPTHIGSMLKLHVVPLESAKLGIGELIPVDVNHLNICKPKKKDAFLYQRTLKFIQDVLATDLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TAE1</accession>
    <name>A0A8C2TAE1_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transmembrane protein 241</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TMEM241</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TAE1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005015777.1">
        <property type="protein sequence ID" value="ENSCJPP00005010690.1"/>
        <property type="gene ID" value="ENSCJPG00005009277.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00510000048348"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005462">
        <property type="term" value="F:UDP-N-acetylglucosamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005010690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="310" mass="34117" checksum="7D7292CB5792A5D1" modified="2022-01-19" version="1">LPWESPASLSVLSSTKYATSASFSSVTCVLTVSWTSLLTHRKRALSNVCKIQAWWQALVGGLLLHVSWKLGWVEINLCSRSEILSWLPASVIFVGIIYAGSRALSRLPIPVFLTIQNAAEVITCGFQKFVQKEQISHLKVCSALFLLVAAVCLPLCDTQFDPNGYLWALIHLICVGAYRVFHKLWKPNSLSDLDQQYINYVFSVVLLASASHPAGDLFSALDFPFLYFYRFHSSCCASGLLGFFLMLHTVKLKSSTTSGQYAAWSFLAKVITAGLSPFFFAMTANVLTISCLVISGVGEALLVYTERTGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TAT3</accession>
    <name>A0A8C2TAT3_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">carbonic anhydrase</fullName>
            <ecNumber evidence="2">4.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC107321524</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alpha-carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="2"/>
    <dbReference type="RefSeq" id="XP_015734001.1">
        <property type="nucleotide sequence ID" value="XM_015878515.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TAT3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005014504.1">
        <property type="protein sequence ID" value="ENSCJPP00005009743.1"/>
        <property type="gene ID" value="ENSCJPG00005008534.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107321524"/>
    <dbReference type="KEGG" id="cjo:107321524"/>
    <dbReference type="GeneTree" id="ENSGT00940000162972"/>
    <dbReference type="OrthoDB" id="429145at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.200.10:FF:000003">
        <property type="entry name" value="Carbonic anhydrase 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="entry name" value="Alpha carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023561">
        <property type="entry name" value="Carbonic_anhydrase_a-class"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952:SF134">
        <property type="entry name" value="CARBONIC ANHYDRASE 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01057">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51069">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51144">
        <property type="entry name" value="ALPHA_CA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034581069" description="carbonic anhydrase" evidence="7">
        <location>
            <begin position="20"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="8">
        <location>
            <begin position="23"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005009743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="322" mass="35129" checksum="211F71C8C149A4DE" modified="2022-01-19" version="1">MGLLGLGVTFITLPLVIRAAEGGQWCYDSQDPKCGPNHWKELKATCGGDKQSPVNIERRWLQRDSSLGDIVFEGYDQAPPGKWRLLNDGHTVMLSLESEPGDEHIAISGGGLPGRYRALQLHFHWGSPTRNGSEHTVDGQQLPMELHIVHINTKYRTLGEAKGHPSGLAVLGCFFQVSEAPNSNYNTIIGGLRNISHAGQAVDLASTFRLGTLLPHVAQLSRYYRYQGSLTTPDCSEAVVWTLFEEPVGISREQLQAFVSSVHFPASGAAPLKMTNNFRPPQPLHSRKVFSSRDATTSSGCPRCPLALLLLLPLLGPFSSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TAV4</accession>
    <name>A0A8C2TAV4_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Transcription factor HES-5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Hairy and enhancer of split 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">HES5</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Transcriptional repressor of genes that require a bHLH protein for their transcription. Plays an important role as neurogenesis negative regulator.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TAV4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005016137.1">
        <property type="protein sequence ID" value="ENSCJPP00005010987.1"/>
        <property type="gene ID" value="ENSCJPG00005009500.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162836"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048708">
        <property type="term" value="P:astrocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030509">
        <property type="term" value="P:BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043010">
        <property type="term" value="P:camera-type eye development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051216">
        <property type="term" value="P:cartilage development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048469">
        <property type="term" value="P:cell maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022010">
        <property type="term" value="P:central nervous system myelination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021953">
        <property type="term" value="P:central nervous system neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072049">
        <property type="term" value="P:comma-shaped body morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090162">
        <property type="term" value="P:establishment of epithelial cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021781">
        <property type="term" value="P:glial cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042491">
        <property type="term" value="P:inner ear auditory receptor cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060122">
        <property type="term" value="P:inner ear receptor cell stereocilium organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072282">
        <property type="term" value="P:metanephric nephron tubule morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048712">
        <property type="term" value="P:negative regulation of astrocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045608">
        <property type="term" value="P:negative regulation of inner ear auditory receptor cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048715">
        <property type="term" value="P:negative regulation of oligodendrocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000737">
        <property type="term" value="P:negative regulation of stem cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021915">
        <property type="term" value="P:neural tube development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097150">
        <property type="term" value="P:neuronal stem cell population maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030513">
        <property type="term" value="P:positive regulation of BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045747">
        <property type="term" value="P:positive regulation of Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046427">
        <property type="term" value="P:positive regulation of receptor signaling pathway via JAK-STAT"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048661">
        <property type="term" value="P:positive regulation of smooth muscle cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065003">
        <property type="term" value="P:protein-containing complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050678">
        <property type="term" value="P:regulation of epithelial cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031641">
        <property type="term" value="P:regulation of myelination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072050">
        <property type="term" value="P:S-shaped body morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007224">
        <property type="term" value="P:smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072086">
        <property type="term" value="P:specification of loop of Henle identity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021537">
        <property type="term" value="P:telencephalon development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd11461">
        <property type="entry name" value="bHLH-O_HES5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000033">
        <property type="entry name" value="Transcription factor HES-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050370">
        <property type="entry name" value="HES_HEY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003650">
        <property type="entry name" value="Orange_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10985">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07527">
        <property type="entry name" value="Hairy_orange"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <name type="scientific">Coturnix japonica</name>
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                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TCX7</accession>
    <name>A0A8C2TCX7_COTJA</name>
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        <recommendedName>
            <fullName evidence="6 17">Alpha-synuclein</fullName>
        </recommendedName>
    </protein>
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    <organism evidence="18 19">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
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        <lineage>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
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            <taxon>Galliformes</taxon>
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        </lineage>
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                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
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        <scope>IDENTIFICATION</scope>
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            </authorList>
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        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
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        <subcellularLocation>
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        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Synapse</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 17">Belongs to the synuclein family.</text>
    </comment>
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    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="GOC"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031092">
        <property type="term" value="C:platelet alpha granule membrane"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098794">
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        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099512">
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    </dbReference>
    <dbReference type="GO" id="GO:0030672">
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043014">
        <property type="term" value="F:alpha-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903136">
        <property type="term" value="F:cuprous ion binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004869">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070840">
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:ferrous iron binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019894">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051219">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140311">
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048156">
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141108">
        <property type="term" value="F:transporter regulator activity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008344">
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071280">
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0034599">
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042416">
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060079">
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060291">
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001774">
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007006">
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        <property type="project" value="Ensembl"/>
    </dbReference>
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    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="10" id="KW-0677">Repeat</keyword>
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    <sequence length="170" mass="18130" checksum="62F861F72CE3D841" modified="2022-01-19" version="1">MDVFMKGLNKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSRTKEGVVHGVTTGLVTSRHCKMRMPGCDSQEYLAEKTKEQVSNVGGAVVTGVTAVAQKTVEGAGNIAAATGLVKKDQLAKQNEEGFLQEGMVNNTDIPADPENEAYEMPPEVNLLWYLLFVSTGERQR</sequence>
</entry>
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    <accession>A0A8C2TDE0</accession>
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        <submittedName>
            <fullName evidence="9">Hes related family bHLH transcription factor with YRPW motif 2</fullName>
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        <name evidence="9" type="primary">HEY2</name>
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        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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    <dbReference type="AlphaFoldDB" id="A0A8C2TDE0"/>
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        <property type="gene ID" value="ENSCJPG00005009151.1"/>
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        <property type="component" value="Chromosome 3"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:protein dimerization activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:regulation of DNA-templated transcription"/>
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        <property type="entry name" value="CLUMA_CG001539, isoform A"/>
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        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
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        <property type="entry name" value="bHLH_dom"/>
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        <property type="entry name" value="HLH_DNA-bd_sf"/>
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        <property type="entry name" value="Orange_dom"/>
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        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED"/>
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    <dbReference type="Pfam" id="PF07527">
        <property type="entry name" value="Hairy_orange"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ORANGE"/>
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    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
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        <property type="entry name" value="Orange domain-like"/>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
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        <location>
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            <end position="398"/>
        </location>
    </feature>
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        <location>
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            <end position="452"/>
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        <location>
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            <end position="34"/>
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    <feature type="region of interest" description="Disordered" evidence="6">
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    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="79"/>
            <end position="91"/>
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    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
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            <end position="207"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
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            <end position="265"/>
        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005010520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="630" mass="67252" checksum="2ED18FF4550417BC" modified="2022-01-19" version="1">WQRPPPAPSRERRTILCGSRGPRGGQGQCGRSPRAVPAAHRFLPRGSRPYLFWFGLVDIFAQIPSKGPLWGTRPESPGAASALPAAAPLRLRPNDRTTPADGTAGVGRATLQRQPREEPAPGVPPIPLPARRETGLPLPSPPAPRRPRRTEPPAPERCTSRPRPSGAPRGHRVKRSRPPAPRYRPPRRPFSPLPAPSRPPPLPPVLPGPAGRRRGTVRGSPPRPLPRPGASLPLLPDPGTFGRDFFPSPGWAAPALPPSLLSSRRGGPGRGRAGALEAVPRRGKEPQRGLAVLAVRCVLCRTGDPVRIYFSLPHAGCGLSHDEATLRGNYLRQRHGRDHRCGQREQLLRIIEKRRRDRINNSLSELRRLVPTAFEKQGSAKLEKAEILQMTVDHLKMLQATGGKGYFDAHSLAMDFMSIGFRECLTEVARYLTSVEGLDTSDPLRVRLVSHLSTCASQREAAAMTSSMAHHHHPLHPHHWAAAFHHLPAALLQPNGLHTPEAAPCRLSSEVPPHGSALLTATFAHTDAALRVPAAGSVAPCVPPLSTSLLSLSATVHAAAAAATAAAQSFPLSFTSTFPMLPPSAAAAAVAAATAITPPLAVSASSNPQQAGNGASGKPYRPWGTEVGAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TDK5</accession>
    <name>A0A8C2TDK5_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Leucine rich repeat containing 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LRRC2</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TDK5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005016262.1">
        <property type="protein sequence ID" value="ENSCJPP00005011081.1"/>
        <property type="gene ID" value="ENSCJPG00005009556.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005016263.1">
        <property type="protein sequence ID" value="ENSCJPP00005011082.1"/>
        <property type="gene ID" value="ENSCJPG00005009556.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154960"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome Z"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF16">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005011082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="377" mass="43881" checksum="8FDD7AB891CA5709" modified="2022-01-19" version="1">MGHQVIIFDFSLIRGLWEARVKKNRERQKKEKERLEKSSLEKIKLEWNFILECRKKGIPQSKYLKNGFVDIDEKILDTYGRTPQLQKRLTLSDETNKERNKFIFQLSGEQWMDFPESLKDHTYLREWHVSNTLIQTVPNYIALFQDLRVLELPKNQINHLPVEIGHLKNLKVLNVSFNNLKSVPSELGCCENLEKLDLSGNMEISDLPFELSNLKQVTVVDVSANKFHSIPICVLRMSNLQWLDISSNNLRDLPEDIDRLDQLQTLLLQKNKLTYLPRALVNMSKLSLLVVSGDDLVEIPTAICESTTGLKFISLKDSPVETIVCEDTEEIIESEREREQFEKEFMKAYIEDLKERGMLSLMVTYSCLGILFQNIIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TFK7</accession>
    <name>A0A8C2TFK7_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fas associated factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FAF1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TFK7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005017784.1">
        <property type="protein sequence ID" value="ENSCJPP00005012254.1"/>
        <property type="gene ID" value="ENSCJPG00005010278.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154831"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990917">
        <property type="term" value="C:ooplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034098">
        <property type="term" value="C:VCP-NPL4-UFD1 AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051059">
        <property type="term" value="F:NF-kappaB binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036337">
        <property type="term" value="P:Fas signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043124">
        <property type="term" value="P:negative regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045740">
        <property type="term" value="P:positive regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902043">
        <property type="term" value="P:positive regulation of extrinsic apoptotic signaling pathway via death domain receptors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045732">
        <property type="term" value="P:positive regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030155">
        <property type="term" value="P:regulation of cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd02990">
        <property type="entry name" value="UAS_FAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17129">
        <property type="entry name" value="Ubl1_FAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17130">
        <property type="entry name" value="Ubl2_FAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01771">
        <property type="entry name" value="UBX_UBXN3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000089">
        <property type="entry name" value="Fas associated factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000122">
        <property type="entry name" value="Fas associated factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000137">
        <property type="entry name" value="Fas associated factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000061">
        <property type="entry name" value="Fas associated factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033043">
        <property type="entry name" value="FAF1-like_UBX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049483">
        <property type="entry name" value="FAF1_2-like_UAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006577">
        <property type="entry name" value="UAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050730">
        <property type="entry name" value="UBX_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322:SF96">
        <property type="entry name" value="FAS-ASSOCIATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322">
        <property type="entry name" value="FAS-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21021">
        <property type="entry name" value="FAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00594">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBX" evidence="2">
        <location>
            <begin position="535"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="521"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005012254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="616" mass="70178" checksum="8062A59DF6ACBEAA" modified="2022-01-19" version="1">QNNWDLVAAINGVIPQENGILQSEYGGETLQGPAYGPTSHSTAASSSSSAFRHVVPSRQIVERQPRMLDFRVEYRDRNVDVVLEDSSTVGDIKHILENELQIPASKMLLKGWKTGDVDDSTVLKTLHLPKNNSLYVLTPDLPPPSSSHSGALQESLNQNFMLIITHREVQREYNLNFSGSSTIQEVKRNVYDLTSIPVRHQQWEGWPPSATDDSMTLAVSGVNFPCHRLTVGRRSSPVQTREQSEEQCTDVHMVSDSDGDDFEDATEFGVDDGEMFGVASSALRKSPMMPENAENEGDALLQFTAEFSSRYGDCHPVYFIGSLEAAFQEAFYGKARDRKLLAIYLHHDESVLTNVFCSQMLCAESIVSYLSQNFITWAWDMTKEANRARFLTMCTRHFGSVVAQTIRTQKTDQFPLFLIIMGKRSSNEVLNVIQGNTTVDELMMRLMAAMEIFSAQQQEDIKDEDEREARENVKREQDEAYRISLEADRAKREAQEREMAEQFRLEQIRKEQEEEREAIRLSLEQSLPPEPKEESTESVSKLRIRTPSGEFFERRFLASSKLQVVFDFVASKGYPWEEFKLLGTFPRRDVTQLDPNKSLQEVKLYPQETLFLEAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TFY2</accession>
    <name>A0A8C2TFY2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein Wnt</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">WNT9A</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Ligand for members of the frizzled family of seven transmembrane receptors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Secreted</location>
            <location evidence="1 11">Extracellular space</location>
            <location evidence="1 11">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the Wnt family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TFY2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005017963.1">
        <property type="protein sequence ID" value="ENSCJPP00005012399.1"/>
        <property type="gene ID" value="ENSCJPG00005010543.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159618"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005109">
        <property type="term" value="F:frizzled binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045165">
        <property type="term" value="P:cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19353">
        <property type="entry name" value="Wnt_Wnt9a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2460.20:FF:000002">
        <property type="entry name" value="Protein Wnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2460.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005817">
        <property type="entry name" value="Wnt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013303">
        <property type="entry name" value="Wnt9a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043158">
        <property type="entry name" value="Wnt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018161">
        <property type="entry name" value="Wnt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027:SF75">
        <property type="entry name" value="PROTEIN WNT-9A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027">
        <property type="entry name" value="WNT RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00110">
        <property type="entry name" value="wnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01894">
        <property type="entry name" value="WNT14PROTEIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01349">
        <property type="entry name" value="WNTPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00097">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00246">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6 11" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="294"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005012399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="402" mass="45250" checksum="524371DD1789C6EE" modified="2022-01-19" version="1">MNCPLAILSLTDVAIAKVFHPNKLRGENKSKYCFLLPSCAHTAESLAVQSLLSQRIPVGCSAHSYPLFLCRLTGNEPLTILPLTSEMEEAAVKAHYKVCDRLKLEKKQRRMCRRDPGVAETLMEAISMSALECQYQFRFERWNCTLEGRYRASLLKRGFKETAFLYAISSAGLTHAMAKACSAGRMERCTCDEAPDLENREAWQWGGCGDNLKYSNKFVKEFLGRKPNKDLRARVDFHNNLVGMKVIKAGVETTCKCHGVSGSCTVRTCWRQLSPFHEIGKQLKQKYETSLKVGSTTNEATGEGDISPPKKSIPGHSDQIPRTTDLVYIDDSPSFCLMSRYSPGTSGRKCYKDKNCDSICCGRGHNTQSRVVTRPCQCQVRWCCYVECKQCTQREEVYTCKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TGP3</accession>
    <name>A0A8C2TGP3_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein FAM110B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FAM110B</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAM110 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015711118.1">
        <property type="nucleotide sequence ID" value="XM_015855632.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015711120.1">
        <property type="nucleotide sequence ID" value="XM_015855634.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015711122.1">
        <property type="nucleotide sequence ID" value="XM_015855636.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015711123.1">
        <property type="nucleotide sequence ID" value="XM_015855637.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015711124.1">
        <property type="nucleotide sequence ID" value="XM_015855638.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015711125.1">
        <property type="nucleotide sequence ID" value="XM_015855639.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015711126.1">
        <property type="nucleotide sequence ID" value="XM_015855640.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032298623.1">
        <property type="nucleotide sequence ID" value="XM_032442732.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032298624.1">
        <property type="nucleotide sequence ID" value="XM_032442733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TGP3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005017755.1">
        <property type="protein sequence ID" value="ENSCJPP00005012227.1"/>
        <property type="gene ID" value="ENSCJPG00005010421.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107310196"/>
    <dbReference type="KEGG" id="cjo:107310196"/>
    <dbReference type="CTD" id="90362"/>
    <dbReference type="GeneTree" id="ENSGT00950000183056"/>
    <dbReference type="OrthoDB" id="10028183at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025740">
        <property type="entry name" value="FAM110"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025741">
        <property type="entry name" value="FAM110_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025739">
        <property type="entry name" value="FAM110_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14758">
        <property type="entry name" value="AGAP005440-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14758:SF2">
        <property type="entry name" value="PROTEIN FAM110B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14160">
        <property type="entry name" value="FAM110_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14161">
        <property type="entry name" value="FAM110_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centrosome-associated FAM110 N-terminal" evidence="8">
        <location>
            <begin position="14"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Centrosome-associated FAM110 C-terminal" evidence="7">
        <location>
            <begin position="254"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005012227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="370" mass="40675" checksum="7867A898E32E3CF1" modified="2022-01-19" version="1">MPTETLPTGSMVKPVSPAVTFTSAVPLRILNKGPDYFRRQAEPNPKRLSAVERLEADKAKYVKSQEVINAKQEPVKPAVLAKPPVCPAAKRALGSPTLKVFSNNAKTESGVQRENLKLEILKNIINSSEGSSSGSGHKHGPRNWPPHRADSTELNRHSFAESLKVYPTQGRSSPQESSSNVSRRLLDQSAETFLHVSHSSSDIRKVTSAKPLKAIPCSSSAPPLPPKPKIAAIATLKSPEIEAVESGCGVSRRPSLQRSKSDLSDRYFRVDADVERFFNYCGLDPEELENLGMENFARANSDIISLNFRSASMISSDCEQSQDSNSDLRNDDSANDRVPYGISAIERNARIIKWLYSIKQARESQKVSHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TH45</accession>
    <name>A0A8C2TH45_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="18">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">USP4</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Deubiquitinating enzyme that removes conjugated ubiquitin from target proteins. Deubiquitinates PDPK1. Deubiquitinates TRIM21. Deubiquitinates receptor ADORA2A which increases the amount of functional receptor at the cell surface. Deubiquitinates HAS2. Deubiquitinates RHEB in response to EGF signaling, promoting mTORC1 signaling. May regulate mRNA splicing through deubiquitination of the U4 spliceosomal protein PRPF3. This may prevent its recognition by the U5 component PRPF8 thereby destabilizing interactions within the U4/U6.U5 snRNP. May also play a role in the regulation of quality control in the ER.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="17">Interacts with RB1 (both dephosphorylated and hypophosphorylated forms). Interacts with RBL1 and RBL2. Interacts with ADORA2A (via cytoplasmic C-terminus); the interaction is direct. Interacts with SART3; recruits USP4 to its substrate PRPF3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the peptidase C19 family. USP4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="18"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2TH45"/>
    <dbReference type="Ensembl" id="ENSCJPT00005018272.1">
        <property type="protein sequence ID" value="ENSCJPP00005012642.1"/>
        <property type="gene ID" value="ENSCJPG00005010737.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156645"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031685">
        <property type="term" value="F:adenosine receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031397">
        <property type="term" value="P:negative regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045947">
        <property type="term" value="P:negative regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045948">
        <property type="term" value="P:positive regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034394">
        <property type="term" value="P:protein localization to cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031647">
        <property type="term" value="P:regulation of protein stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd02674">
        <property type="entry name" value="Peptidase_C19R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000013">
        <property type="entry name" value="ubiquitin carboxyl-terminal hydrolase 15 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2230.10">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035927">
        <property type="entry name" value="DUSP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006615">
        <property type="entry name" value="Pept_C19_DUSP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028135">
        <property type="entry name" value="Ub_USP-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF45">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06337">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14836">
        <property type="entry name" value="Ubiquitin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143791">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6 18" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="11 18" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="13" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="9 18" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="USP" evidence="19">
        <location>
            <begin position="234"/>
            <end position="850"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00037971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00045453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00046862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005012642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="870" mass="97535" checksum="2D25B8A298623004" modified="2022-01-19" version="1">MCVSIPDGETQSLKEHLIAQLDYVLVPSSAWQKLVSWYGCIEGQQPIVRKVMEFGLYAKHCEVEVYPLELKLCESSSPSNVISCCFSRRDSVATLVKEVRKLFKIPAEKDVRLWSSHFDGSYEQLSELGVTLEDANIYHGELVLIEVRNGDGTWPQHPFLAKSSTATGRNFTTSTKPSASSYSTASATSVITNGDSSNSYGLSSSSLGRGGSGFACNSYSSNRDSASLSQPGLCGLSNLGNTCFMNSALQCLSNTPPLTDYFLEDKYEAEINHSNPLGMRGEIAEAYAELIKQIWSGRQSHVAPRMFKTQVGRFAPQFSGYQQQDSQELLAFLLDGLHEDLNRVKKKPYLELKDANGRPDSVVAKEAWENHRLRNDSIIVDIFHGLFKSTLVCPKCSKVSVTFDPFCYLTLPLPLKRDRLLEVTLVYADPQRRPVQYRVVVPMMGAISDLCDSLSKLSGVPAEKMVVTDVYNHRFHKIFQADEGLNHIMPKDDIFVYEVCKPSEDGSEYITLSVYFREKAARQSSSTSGTVLFGQPLLVSVPKHKLTVDHLYGVVLERISRYVKLPVAEVYSAPCPDRGACNGSSSVAEGDIEEMEHQDDGQEGREKLAEVDSCPSEGCMQVEPTRGLQPCKKQYFTFSLVNLYGTSEINSIVEGKLLKLNAFSTLAIDWDSETRRLLFDEQEAQAFEKHASVLQPQKMKAVVALKDCIELFTTMETLGEHDPWYCPNCKKHQQATKKFDLWSLPKILVVHLKRFSYSRYWRDKLDTVVEFPIRGLNMSEFVCDPRGSSYVYDLIAVSNHYGAMGVGHYTAYAKNKVNGKWYYFDDSSVSLASEDQIVTKAAYVLFYQRRNEEHVAPSPPQEECDGMDTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2THS3</accession>
    <name>A0A8C2THS3_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Hedgehog acyltransferase like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">HHATL</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the membrane-bound acyltransferase family. HHAT subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015708504.1">
        <property type="nucleotide sequence ID" value="XM_015853018.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2THS3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005017942.1">
        <property type="protein sequence ID" value="ENSCJPP00005012381.1"/>
        <property type="gene ID" value="ENSCJPG00005010511.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107308844"/>
    <dbReference type="KEGG" id="cjo:107308844"/>
    <dbReference type="CTD" id="57467"/>
    <dbReference type="GeneTree" id="ENSGT00530000063629"/>
    <dbReference type="OrthoDB" id="420606at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051085">
        <property type="entry name" value="MB_O-acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13285">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13285:SF19">
        <property type="entry name" value="PROTEIN-CYSTEINE N-PALMITOYLTRANSFERASE HHAT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="291"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="427"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="465"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005012381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="503" mass="57713" checksum="AB96B997EB56DBD4" modified="2022-01-19" version="1">MGVKAMLPSHELGFYALVVTCAVLYSGSGIFEASRDSMNRKAFRDGIKPGWHYFGRKMDVADFEWVMWFTSFRNVIIFTLSGHVLFAKVCSMTVPQHRAVVYMLYGMLAVLGSMGLTYLMIILSHCLILYSVALAKQKWLCYVAGLCCLASIKLEPFSSWQSGFVTGAFDLQDVLFYGGSGFTIMRCMSFALESSERKEGVFSIFDLLKYNFYLPFFFFGPVMTFDQFHMQVSTRDLRRKDDEMKNIRVHALLHVGAIIAVDIFFHFFYILTLPSDLKFVNRLSDWALAGLAYSNLVYDWVKAAVMFGVINTIARLDHLDPPQPPKCITMLYVFAETHFDRGINDWLCKYVYDHIGENHDNIMKELVATIATFAVTTLWLGPCEIVYIWSVFNCFGLNFELWVQKFFQWKPLSKLEAKMSEATSRRIRALFGAANFWAIVLYNILALNSLEFALLVTKRLLVTGFPVSTLSIWFITYCGVQLIKERERILAMEEEKSEKPKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TI42</accession>
    <name>A0A8C2TI42_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Adhesion G protein-coupled receptor D2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ADGRD2</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TI42"/>
    <dbReference type="Ensembl" id="ENSCJPT00005018515.1">
        <property type="protein sequence ID" value="ENSCJPP00005012824.1"/>
        <property type="gene ID" value="ENSCJPG00005010881.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161534"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15255">
        <property type="entry name" value="7tmB2_GPR144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000252">
        <property type="entry name" value="Adhesion G protein-coupled receptor D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.220.50:FF:000046">
        <property type="entry name" value="Adhesion G protein-coupled receptor D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000171">
        <property type="entry name" value="Adhesion G-protein coupled receptor D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032471">
        <property type="entry name" value="AGRL2-4_GAIN_subdom_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001759">
        <property type="entry name" value="PTX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011">
        <property type="entry name" value="ADHESION G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011:SF58">
        <property type="entry name" value="ADHESION G-PROTEIN COUPLED RECEPTOR D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16489">
        <property type="entry name" value="GAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00354">
        <property type="entry name" value="Pentaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00159">
        <property type="entry name" value="PTX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50221">
        <property type="entry name" value="GAIN_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51828">
        <property type="entry name" value="PTX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034993060" evidence="11">
        <location>
            <begin position="20"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="716"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="752"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="781"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="818"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="856"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="914"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="937"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="domain" description="Pentraxin (PTX)" evidence="14">
        <location>
            <begin position="116"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="GAIN-B" evidence="12">
        <location>
            <begin position="527"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="13">
        <location>
            <begin position="713"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="993"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1200"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1210"/>
            <end position="1223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005012824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1265" mass="140658" checksum="6A9104EDD894899D" modified="2022-01-19" version="1">MRDLRPDSWFFSFLVGSLSRTLFTSAALAENQTSKDFVPVMIETLRHVYEYVPTALDWWHADRFCDQRFAQLLFEPPDSEQSSFSKLLQSHHIRGSVWLNERDGVLHKPKWRRNHIVPVLVFGDKTDTKYVKVLSDFPVLPAVTACAHLQWDTRTQEIATVFSYAVPAFINEFQLRGFVDEEGFVRFALIVHGHHSPYLPMFRADGQWHHFCVTWQQENGTWAIYADGKRRASASGLYAVGLAAPQAIYGQGTFIIGQDQDSLGGTFKAKESFSGNITDLHIWQKVLSVEQIENVRSCWMVEQELVFGWSLNALEIESTVEEVIAQFLCPGPVEECQVFEVGSSGFRHTSCLQSLPFICRYRKDAYWQLKKAQLESSHLLVSHVNTLAKRMMIPENIFTSNVRDMNLSVALGTLDVLATVLRKEETPVESSDLLMVLQLLKQVADVEVQEREELEMLEQLGQYYVEVTELILEEQNIESWSSISQAVRGPMAVVELCDRVVSLLAPLLNSGRTKITIQHQNVGMEVRKLELSSQQLSTETYLIQSPEEDRPDFIEIPVEEMQRLKAKGLRRVTVKNMWFGYGSLQRCLPGPGSSAAFQDEAASDGGQKYLSTAVGTAVISSTVLSDYQEISTSVRYRLQHHSQDLPDKLVGPICAFWNFSLSPEAGGMWSTAGCSVVTSLPDSTVCFCNHTTNFAVLLQMYEIERTTKEELTLQTLTFIGCGVSFCALVVTFILFLVVGVPKSERTTVHKNLIFALAAAEALLMFSEVAKTNQVLCFLVTAFLHLLFMAAFSWMLVEGLLLWSKVVAVNMSEDRRMKFYYATGWGLPSIIVGVTLATSFNNYVADNHCWLNVQTNVIWAFVGPVLFILAVNTFVLFRVVMVTVSSARRRAKMLTPNSSLENQIGIQIWATAKPILVLLPVLGLTWVCGILVHLSIVWAYVFIMLNSLQGLYIFLVYAIYNSEVRNAIQRMKDKKKALSFTNCSHPINYLSSPRNTTSWETGKPSPAVESAPSNPVQKDPPMKNITSRGNFGGKIPMGISSVMSPERPAVELTAFKSSGNISLFIFNLFYANTAFSDCIVEHRLEGGGQVMLAQTLGSVLFPSCLGGCSPGKAAGVCPGKGCSRYEEQGVPRSPTVLPLPAVPAAQLSHEPLQSSATGAHLPAPMWHFPASLQPFCCLHLSAICCTPAVKLQLTDMQQMQIGTRKQQAGPSAPGGLARSRGGSSSLMPQGIVKQQLLQESWVGVRSNLLLQKGSQERWGVQTGMDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TIQ4</accession>
    <name>A0A8C2TIQ4_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Membrane bound O-acyltransferase domain containing 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MBOAT2</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015714896.1">
        <property type="nucleotide sequence ID" value="XM_015859410.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TIQ4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005018746.1">
        <property type="protein sequence ID" value="ENSCJPP00005013017.1"/>
        <property type="gene ID" value="ENSCJPG00005011009.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107312206"/>
    <dbReference type="KEGG" id="cjo:107312206"/>
    <dbReference type="CTD" id="129642"/>
    <dbReference type="GeneTree" id="ENSGT01030000234564"/>
    <dbReference type="OrthoDB" id="286734at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047184">
        <property type="term" value="F:1-acylglycerophosphocholine O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106262">
        <property type="term" value="F:1-acylglycerophosphoethanolamine O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106263">
        <property type="term" value="F:1-acylglycerophosphoserine O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030258">
        <property type="term" value="P:lipid modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036151">
        <property type="term" value="P:phosphatidylcholine acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036152">
        <property type="term" value="P:phosphatidylethanolamine acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036150">
        <property type="term" value="P:phosphatidylserine acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032330">
        <property type="term" value="P:regulation of chondrocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049941">
        <property type="entry name" value="LPLAT_7/PORCN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906:SF7">
        <property type="entry name" value="LYSOPHOSPHOLIPID ACYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906">
        <property type="entry name" value="PORCUPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="377"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="415"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="443"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005013017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="518" mass="59599" checksum="03D8BB2666EDE7D8" modified="2022-01-19" version="1">MATSTTGSTLLQPLSNAVRLPVDQVNFVVCQLFALLAAIWFRTYLHSSKTSPFIRHVVATLLGLYLALFCFGWYALHFVIQSGISYYLMIIIGVENMHKYCFVFALGYLTVCQITRVYIFDYGQYSADFSGPMMIITQKITSLAFEIRDGMFRKNEDLTPSQRCLAVRRMPSLLEYLSYNCNFMGILAGPLCSYKDYITFIEGRSYQLQQSEANGKEDTKYEQTDPSPNIAVAQKLLVCGLSLLFHMTITKTLPVEYNIDENFRATASWPVRVFYLYLSLMAARPKYYFAWTLADAINNAAGFGFRGYDKNGVTRWDLISNLRIQQIESSTSFKMFLDNWNIQTALWLKRVCYERATFSPTIQTFILSAIWHGVYPGYYLTFLTGILMTLAARAIRNNIRHYFVESPAVKLCYDIITWMTTQVAISYTVVPFVLLSVKPSFTFYSSCYFCLHIASILVLLVFPLKRTQKGNKKHESIQPVWSKKLEEENLLQKNSYSTTNNSFSQREEITCRYQALKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TIY7</accession>
    <name>A0A8C2TIY7_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nuclear FMR1 interacting protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">NUFIP2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TIY7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005020779.1">
        <property type="protein sequence ID" value="ENSCJPP00005014615.1"/>
        <property type="gene ID" value="ENSCJPG00005012186.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00440000038328"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032747">
        <property type="entry name" value="NUFIP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28333:SF2">
        <property type="entry name" value="FMR1-INTERACTING PROTEIN NUFIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28333">
        <property type="entry name" value="NUCLEAR FRAGILE X MENTAL RETARDATION-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15293">
        <property type="entry name" value="NUFIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="563"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="178"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="365"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="590"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005014615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="680" mass="71931" checksum="7DB9BDBC0128A795" modified="2022-01-19" version="1">PLGPAATQRPARPRKASSPPSPPPMEEQPPHHPHHHHHGHHHHHHHHPHHRHFCYYPQSSFLPPPDGRAQPKATLRHPEGPKRRTGYGELNGNAGDREVSLKSLCSEETTSPTSRVPNGSQQPADPNVTPKPSVKGSSLGKAAIKPKNFVQKNSMDKKNEKPYDSKVREAQPADKQDGVSVPNGVVSGGATYITNGYVGKGGADNDGSGSESGYTTPKKRKGRRNSAKGCESLNLTQDKVMQQEVGTPALKQELESFKPDYSEQKGNRIENTKPVWKYEAGGGGAGRGKPGIGDVQRKNSDAKPGISGKKFDERPKGKHASSAASKEDSWTLFKPPPVFPVDNSSAKIVPKISYASKVKENLNKAAQPPSASSSSSSSSSAGEAQPAPSSRLSQVPMSAMKSVTSASFSNGPILAGTDGTVYPAGAQPLLASAAAAAAPVPPTPSDAVTPDVGAAPAAVEQKKSNLFIYPSNMQTVLLGTAQVDFPSQTNQQNLGDIFQNQWGLSFINEPSAGPDTAVGKSADSQSMEVTFQGEYPAALVSQCAEIVPSGAEQPVFPKAYELDKRTNPSPALSAAPKPGTAGEGGGAALESHHAGELQKAEAGSQGALVFLSKDYEVENPLASPTNNLLSSAKEQGYQRGLERKDSWGSFDLSAAVKYHTKGNDPKRIITYDEAMDHPDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TJ17</accession>
    <name>A0A8C2TJ17_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor EC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">TFEC</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MiT/TFE family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015709226.1">
        <property type="nucleotide sequence ID" value="XM_015853740.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TJ17"/>
    <dbReference type="Ensembl" id="ENSCJPT00005020766.1">
        <property type="protein sequence ID" value="ENSCJPP00005014609.1"/>
        <property type="gene ID" value="ENSCJPG00005012178.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005020767.1">
        <property type="protein sequence ID" value="ENSCJPP00005014610.1"/>
        <property type="gene ID" value="ENSCJPG00005012178.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107309175"/>
    <dbReference type="KEGG" id="cjo:107309175"/>
    <dbReference type="CTD" id="22797"/>
    <dbReference type="GeneTree" id="ENSGT00940000159404"/>
    <dbReference type="OrthoDB" id="6242697at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd18925">
        <property type="entry name" value="bHLHzip_TFEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000003">
        <property type="entry name" value="microphthalmia-associated transcription factor isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021802">
        <property type="entry name" value="MiT/TFE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031867">
        <property type="entry name" value="MiT/TFE_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45776">
        <property type="entry name" value="MIP04163P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45776:SF1">
        <property type="entry name" value="TRANSCRIPTION FACTOR EC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11851">
        <property type="entry name" value="DUF3371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15951">
        <property type="entry name" value="MITF_TFEB_C_3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="13">
        <location>
            <begin position="232"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="412"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="285"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="416"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005014609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="440" mass="49443" checksum="D475FFA89A3645F5" modified="2022-01-19" version="1">MLQALTGLQFQLRGKLRDQEWAEKYSQETRARYPQCRMPVSQNPGFNGFLPVGAHFSSDKAPAISEVQTHLENQSRYHIQQSQRHQVKQYLTLDTKLSSQTLSLSHSHTVQPTGVTSILRNGHMPPVSDIGTPESPVTKLLALGGEHENAMEEVIEDIINMESSFNDEGIGCSETPLLMQRTLSSSILDIYNSDQGMAPANMSLTNASCPANLPVKRELTEADTRAMAKERQKKDNHNLIERRRRYNINYRIKELGTLIPKSNDPDMRWNKGTILKASVEYIKWLQKEQQRARELEHRQKKLEHANRRLLLRIQELEIQARAHGLPIMSSLSAVDLAAQVIKQHSYPGENSVDYSQQMPLAHEPNSDVCDGSTAFSDPLSHFTDLSFSAALKEEQRLEEILLDDTVSPFGADPLLSSTSPAASKESSRRSSFSTDDGDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TK32</accession>
    <name>A0A8C2TK32_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">2-hydroxyacyl-CoA lyase 1</fullName>
            <ecNumber evidence="17">4.1.2.63</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">2-hydroxyphytanoyl-CoA lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">Phytanoyl-CoA 2-hydroxylase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="29" type="primary">HACL1</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="29" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="29" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>2-hydroxy-3-methylhexadecanoyl-CoA = 2-methylpentadecanal + formyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:25379"/>
            <dbReference type="ChEBI" id="CHEBI:49190"/>
            <dbReference type="ChEBI" id="CHEBI:57376"/>
            <dbReference type="ChEBI" id="CHEBI:58784"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:25380"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>2-hydroxyoctadecanoyl-CoA = heptadecanal + formyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:55196"/>
            <dbReference type="ChEBI" id="CHEBI:57376"/>
            <dbReference type="ChEBI" id="CHEBI:74116"/>
            <dbReference type="ChEBI" id="CHEBI:138631"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:55197"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>2-hydroxyphytanoyl-CoA = 2,6,10,14-tetramethylpentadecanal + formyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:25355"/>
            <dbReference type="ChEBI" id="CHEBI:49189"/>
            <dbReference type="ChEBI" id="CHEBI:57334"/>
            <dbReference type="ChEBI" id="CHEBI:57376"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:25356"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 2-hydroxy-3-methyl fatty acyl-CoA = a 2-methyl-branched fatty aldehyde + formyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:25375"/>
            <dbReference type="ChEBI" id="CHEBI:49188"/>
            <dbReference type="ChEBI" id="CHEBI:57376"/>
            <dbReference type="ChEBI" id="CHEBI:58783"/>
            <dbReference type="EC" id="4.1.2.63"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:25376"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>an (R)-2-hydroxy-long-chain-fatty acyl-CoA = a long-chain fatty aldehyde + formyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:67444"/>
            <dbReference type="ChEBI" id="CHEBI:17176"/>
            <dbReference type="ChEBI" id="CHEBI:57376"/>
            <dbReference type="ChEBI" id="CHEBI:170012"/>
            <dbReference type="EC" id="4.1.2.63"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:67445"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism; fatty acid metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 24">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.63" evidence="17"/>
    <dbReference type="RefSeq" id="XP_015709192.1">
        <property type="nucleotide sequence ID" value="XM_015853706.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TK32"/>
    <dbReference type="Ensembl" id="ENSCJPT00005021474.1">
        <property type="protein sequence ID" value="ENSCJPP00005015119.1"/>
        <property type="gene ID" value="ENSCJPG00005012565.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107309164"/>
    <dbReference type="KEGG" id="cjo:107309164"/>
    <dbReference type="CTD" id="26061"/>
    <dbReference type="GeneTree" id="ENSGT00940000156802"/>
    <dbReference type="OrthoDB" id="10006023at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106359">
        <property type="term" value="F:2-hydroxyacyl-CoA lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001561">
        <property type="term" value="P:fatty acid alpha-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903512">
        <property type="term" value="P:phytanic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006625">
        <property type="term" value="P:protein targeting to peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd02004">
        <property type="entry name" value="TPP_BZL_OCoD_HPCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07035">
        <property type="entry name" value="TPP_PYR_POX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000006">
        <property type="entry name" value="2-hydroxyacyl-CoA lyase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000027">
        <property type="entry name" value="2-hydroxyacyl-CoA lyase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000038">
        <property type="entry name" value="2-hydroxyacyl-CoA lyase 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045025">
        <property type="entry name" value="HACL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006721">
        <property type="entry name" value="PRK09259.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43710">
        <property type="entry name" value="2-HYDROXYACYL-COA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43710:SF2">
        <property type="entry name" value="2-HYDROXYACYL-COA LYASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="25" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 24" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="25" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="25" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="28">
        <location>
            <begin position="5"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="26">
        <location>
            <begin position="193"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="27">
        <location>
            <begin position="391"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00050321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00051426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00069582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00075677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00081652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="568" mass="61967" checksum="8EC76FA9E8416453" modified="2022-01-19" version="1">MEELSGAQLIAEALRAQNIEYMFGVVGIPITEVAVAAQAAGIKYIGMRNEQSACYAASAVGYLTGRPGVCLVVSGPGFLHTLGGMANATINCWPLIVIGGSSDRNQETMGAFQEFPQVEAARLYNKLSVRPSSLEAIPAVIEKAVRTSIYGRPGSCYIDIPGDFVNLQVNKSSVKYVECCPPPPVSTAEHSAVSEAAALIAHAKQPLLIIGKGAAYSRAENNIRKLVDLSGLPFLPTPMAKGVVPDNHPNCVAAARSTALLHADVIILLGARLNWILHFGLPPRFRQDVKVIQIDVCAEEMGNNVRPAAMLLGDINAITKQLLEEFSKRSLKYPSNSEWWKRLREKMLNNEERSKDLALQKSLPMNYYTVFHHIKELVPKDCILVSEGANTMDIGRTMLPNYHPRQRLDAGTFGTMGVGLGFAIAAALVAKDRTPEKRVICIEGDSAFGFSGMEVETICRYNLPILIIIVNNNGIYTGLDAGSWKEMLQYGDPVTSVPPVSLLPNAHYEKIMSAFGGKGYFVNTPEELQNAVKASLADKRTPSLINVMIDPQSERKKQEFPWLTRSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TKW0</accession>
    <name>A0A8C2TKW0_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Homeobox A6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">HOXA6</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the Antp homeobox family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TKW0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005021426.1">
        <property type="protein sequence ID" value="ENSCJPP00005015086.1"/>
        <property type="gene ID" value="ENSCJPG00005012530.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161585"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009952">
        <property type="term" value="P:anterior/posterior pattern specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048706">
        <property type="term" value="P:embryonic skeletal system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000879">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050296">
        <property type="entry name" value="Antp_homeobox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017995">
        <property type="entry name" value="Homeobox_antennapedia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001827">
        <property type="entry name" value="Homeobox_Antennapedia_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45659">
        <property type="entry name" value="HOMEOBOX PROTEIN HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45659:SF14">
        <property type="entry name" value="HOMEOBOX PROTEIN HOX-A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00025">
        <property type="entry name" value="ANTENNAPEDIA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00032">
        <property type="entry name" value="ANTENNAPEDIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6 10 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0371">Homeobox</keyword>
    <keyword evidence="9 10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="13">
        <location>
            <begin position="151"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="209" mass="24053" checksum="BAA5B80938ADBE8F" modified="2022-01-19" version="1">MSSYFVNPTFPGSLPAGQDSFLGQIPLYPAGYDALRHFPASYGASSLQDKTYTSPCFYQQSNTVIACNRASYEYGASCFYSDKEISSASPSGSGKQRGHGDYLHFSPEQQYKSNGVQSKIVNDEGTDRKYTSPVYPWMQRMNSCAGTVYGAHGRRGRQTYTRYQTLELEKEFHFNRYLTRRRRIEIANALCLTERQIKIWFQNRRMKWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TLN8</accession>
    <name>A0A8C2TLN8_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Substance-P receptor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">NK-1 receptor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Tachykinin receptor 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">TACR1</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TLN8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005020381.1">
        <property type="protein sequence ID" value="ENSCJPP00005014292.1"/>
        <property type="gene ID" value="ENSCJPG00005011936.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153745"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061827">
        <property type="term" value="C:sperm head"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097225">
        <property type="term" value="C:sperm midpiece"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016496">
        <property type="term" value="F:substance P receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007204">
        <property type="term" value="P:positive regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902093">
        <property type="term" value="P:positive regulation of flagellated sperm motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd16002">
        <property type="entry name" value="7tmA_NK1R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000078">
        <property type="entry name" value="Neuromedin-K receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001681">
        <property type="entry name" value="Neurokn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000046">
        <property type="entry name" value="NK1_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46925">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR TKR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46925:SF4">
        <property type="entry name" value="SUBSTANCE-P RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01024">
        <property type="entry name" value="NEUROKININ1R"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00244">
        <property type="entry name" value="NEUROKININR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 17" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0564">Palmitate</keyword>
    <keyword evidence="10 17" id="KW-0675">Receptor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 17" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 17 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="36"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="20">
        <location>
            <begin position="53"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="376"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="383"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="109"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR601681-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005014292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="412" mass="47294" checksum="4852793D259AFBE0" modified="2022-01-19" version="1">MNDTPPLEAELEQRRLLNASLNESYANQFIQPPWQVALWAIAYTLIVVVSVVGNVVVMWIILAHKRMRTVTNYFLVNLAFAEASMSAFNTVVNFTYAIHNEWYYGLLYCKFHNFFPIAAVFASIYSMTAIALDRYMAIIHPLQPRLSATATKVVIGVIWLLAFLLAFPQGYYSVTAELPNRTVCLVEWPENTIIFSRYHFSMTVLIYFLPLLVIGCAYTVVSITLWASEIPGDSSDRYHEQVSAKRKVVKMMIIVVCTFALCWLPYHIYFTLQYINPDWYLQKFIQQVYLAVMWLAMSSTMYNPIIYCCLNDRFRVGFKHAFRWCPFVSAAEYEGLEMRSARYLQTQSSMYKVSRIETTVSLAAGAAEEELEENKKSKRLSVDMTSNGSSRSDSKTVSESFSFYSNTTAQDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TNZ2</accession>
    <name>A0A8C2TNZ2_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ADP-ribosylation factor-like protein 8B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC107308931</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lysosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TNZ2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005020672.1">
        <property type="protein sequence ID" value="ENSCJPP00005014542.1"/>
        <property type="gene ID" value="ENSCJPG00005012118.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000165940"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904115">
        <property type="term" value="C:axon cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008089">
        <property type="term" value="P:anterograde axonal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04159">
        <property type="entry name" value="Arl10_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000247">
        <property type="entry name" value="ADP-ribosylation factor-like GTPase 8A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044154">
        <property type="entry name" value="Arl8a/8b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45732:SF20">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE 8B-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45732">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="6 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0458">Lysosome</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="65"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="79"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="144"/>
            <end position="151"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="247"/>
            <end position="250"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005014542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="311" mass="34204" checksum="EE508CEEA9E37D05" modified="2022-01-19" version="1">MVHPDPAATSRHSPAPAAGGTRHTTSQTPPRPPAQPRPPPPPRRAPLGRAKPLPRLQQVAAAEGRRRRHHVRPRRALRARAASSAADPGPSRPAAMPSSEAVPLGLGACRRSGALAGMLALVARVLEWLRSLFWKEEMELTLVGLQYSGKTTLLTVLASGQFTEDMIPTVGFNMRKITKGNVTIKVWDIGGQPRFRSMWERYCRGVNAVVYMVDAADLEKVEASKNELHSLIDKPQLHGIPVLVLGNKRDLPGALDEKQLIEKLNLSAIQDREICCYSISCKEKDNIGKLLFLTASSLYALDQMFRNINEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TPB0</accession>
    <name>A0A8C2TPB0_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">BMS1 ribosome biosis factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">BMS1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. BMS1 subfamily.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSCJPT00005021829.1">
        <property type="protein sequence ID" value="ENSCJPP00005015384.1"/>
        <property type="gene ID" value="ENSCJPG00005012672.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153195"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01882">
        <property type="entry name" value="BMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000105">
        <property type="entry name" value="BMS1 ribosome biogenesis factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012948">
        <property type="entry name" value="AARP2CN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039761">
        <property type="entry name" value="Bms1/Tsr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037875">
        <property type="entry name" value="Bms1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007034">
        <property type="entry name" value="BMS1_TSR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030387">
        <property type="entry name" value="G_Bms1/Tsr1_dom"/>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TQ12</accession>
    <name>A0A8C2TQ12_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Muscarinic acetylcholine receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">CHRM4</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cell membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Postsynaptic cell membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
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        <property type="gene ID" value="ENSCJPG00005013889.1"/>
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        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:G protein-coupled acetylcholine receptor activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:G protein-coupled serotonin receptor activity"/>
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        <property type="project" value="Ensembl"/>
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    </dbReference>
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        <property type="term" value="P:regulation of locomotion"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
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        <property type="entry name" value="Musac_Ach_M4_rcpt"/>
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        <property type="entry name" value="5-HYDROXYTRYPTAMINE RECEPTOR"/>
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    </dbReference>
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        <property type="entry name" value="GPCRRHODOPSN"/>
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        <property type="entry name" value="MUSCARINICR"/>
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        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 14" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 13" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12 14" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="9 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0770">Synapse</keyword>
    <keyword evidence="11 13" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="42"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
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            <begin position="79"/>
            <end position="105"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
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            <begin position="117"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
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            <end position="184"/>
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            <begin position="409"/>
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    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="16">
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            <begin position="59"/>
            <end position="464"/>
        </location>
    </feature>
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    </evidence>
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    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005016950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="490" mass="54953" checksum="2CDFDB4BF7DD7995" modified="2022-01-19" version="1">MHNLSAQPWQAKMANLTYDNVTLSNRSEVAIQPPTNYKTVELVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGVFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWILSFILWAPAILFWQFIVGKRTVHERECYIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVRRHKPESRKERKGKSLSFFKAPPVKQNNNNSPKRAVEVKEEVRNGKVDDQPSAQTEATGQQEEKETSNESSTVSMTQTTKDKPTTEILPAGQGQSPAHPRVNPTSKWSKIKIVTKQTGTECVTAIEIVPAKAGASDHNSLSNSRPANVARKFASIARSQVRKKRQMAAREKKVTRTIFAILLAFILTWTPYNVMVLINTFCETCVPETVWSIGYWLCYVNSTINPACYALCNATFKKTFKHLLMCQYRNIGTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TRH7</accession>
    <name>A0A8C2TRH7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Homeobox protein DBX2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Developing brain homeobox protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">DBX2</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the H2.0 homeobox family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TRH7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005022952.1">
        <property type="protein sequence ID" value="ENSCJPP00005016310.1"/>
        <property type="gene ID" value="ENSCJPG00005013417.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005022953.1">
        <property type="protein sequence ID" value="ENSCJPP00005016311.1"/>
        <property type="gene ID" value="ENSCJPG00005013417.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005022954.1">
        <property type="protein sequence ID" value="ENSCJPP00005016312.1"/>
        <property type="gene ID" value="ENSCJPG00005013417.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005022955.1">
        <property type="protein sequence ID" value="ENSCJPP00005016313.1"/>
        <property type="gene ID" value="ENSCJPG00005013417.1"/>
    </dbReference>
    <dbReference type="KEGG" id="cjo:107309811"/>
    <dbReference type="GeneTree" id="ENSGT00950000183093"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007173">
        <property type="term" value="P:epidermal growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061351">
        <property type="term" value="P:neural precursor cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000187">
        <property type="entry name" value="homeobox protein DBX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051662">
        <property type="entry name" value="H2.0_Homeobox_NeuralPatt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000047">
        <property type="entry name" value="HTH_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24331">
        <property type="entry name" value="DBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24331:SF4">
        <property type="entry name" value="HOMEOBOX PROTEIN DBX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00031">
        <property type="entry name" value="HTHREPRESSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 7 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="216"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="7">
        <location>
            <begin position="218"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="316"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="332"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00072002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00082385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005016310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="366" mass="39568" checksum="F83DAC688581075A" modified="2022-01-19" version="1">MRLDTPSSPAERRGVPPPSAPLPAALPAPLPGAPSQPSEGPRPGRGGPGRAALAMLPSALYWDLVGSSALLNLPAAPGFGSLGKSFLIENLLRAGAPQSPAQLRPLPASPVPLKLCPAAEQISPSGGPYPTRWAFQVLNPSAADGGRLAARAPAADRCGVFPTAATALSKHFFLRAPPFYSACCGGSCQHPASPTAFPREESVLPLLTQESNSKARRGILRRAVFSEDQRKALEKMFQKQKYISKTDRKKLAINLGLKESQVKIWFQNRRMKWRNSKEKEVLSNRCLQEGLQENYLSQSAMNFASPYPSVWEVSQEQTSPRWMEKSPGNAERLTSTQPPPRANSSQSPLYLYPDHDAANKAVTSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TRS6</accession>
    <name>A0A8C2TRS6_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 17">Alkaline phosphatase</fullName>
            <ecNumber evidence="4 17">3.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="15">Binds 1 Mg(2+) ion.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15">Binds 2 Zn(2+) ions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the alkaline phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.1" evidence="4 17"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2TRS6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005023442.1">
        <property type="protein sequence ID" value="ENSCJPP00005016724.1"/>
        <property type="gene ID" value="ENSCJPG00005013722.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183063"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004035">
        <property type="term" value="F:alkaline phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16012">
        <property type="entry name" value="ALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000008">
        <property type="entry name" value="Alkaline phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001952">
        <property type="entry name" value="Alkaline_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018299">
        <property type="entry name" value="Alkaline_phosphatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596:SF93">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00245">
        <property type="entry name" value="Alk_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00113">
        <property type="entry name" value="ALKPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00098">
        <property type="entry name" value="alkPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00123">
        <property type="entry name" value="ALKALINE_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10 15 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 15 17" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="14">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
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        <location>
            <position position="363"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
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        <location>
            <position position="400"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
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        <location>
            <position position="401"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
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        <location>
            <position position="471"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005984"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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        <source>
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        <source>
            <dbReference type="RuleBase" id="RU003947"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005016724.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="548" mass="59204" checksum="9E325FC59D10DD49" modified="2022-01-19" version="1">MDTTAVHSSWDLTEPGLPGSAPGIGPWDGSELSVLRAPQELGDVEDAEKTPHYWNEGARRKLEAALTLQPAAQRAKNIILFVGDGMGLPTVSAARIYKGQLAGSSGEESVLAMEMFPHVALAKTYTIDRQVPDSAGTGTAYLCGVKTNAKTLGLSGAAVYGKCRTAFGNEVDSVLHRARLAGKSVGIVTTTRVQHASPAAAYAHSASRSWYADANMPRESLRDGCKDIAHQLVHNTDINVILGGGRAYMSPRWTPDPEYPEDPTQNGTRRDGRDLVSEWLSSRKGAHYVWDKKGLDAIDDTSVSHLMGLFEPKDMKYELNRNATTDPSIVEMTEKAIRILRRNPNGFFLFVEDECGRIDHGHHSGRAKQALMEAVMLDRAVARAGELTEPSDTLTVVTADHSHVFTFGGNTLRGASIFGLAPKKAKDKRAYTSILYGNGPGYSIRDGGRPAASLPTDYRQQAAVPLDLETHSGEDVVVLAQGPMAHLFHGVQEQHYVAHAIAYAACLKPYDARPRCGSPRRASSSTQHSPRPLLALLALCMAAFMVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TT56</accession>
    <name>A0A8C2TT56_COTJA</name>
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        </submittedName>
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        <name evidence="4" type="primary">LOC107319345</name>
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        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
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        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
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                <consortium name="Ensembl"/>
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        <location>
            <begin position="33"/>
            <end position="56"/>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005018040.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
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    <sequence length="351" mass="38666" checksum="B3E698A9BB832DE9" modified="2022-01-19" version="1">MCNAALQSGARRHTVCLLRQLLPKQNLAVMKDFFFLSTVIFFHLPLISGSSIRIGIGSNSSLYEQSILPCKKEELQCGTGLCLSNWLRCRYRKDCGRDYMSIQLTCSKVHLNQSSPTSELPSYSENGSDASLLVSPLLVAGVVIGLVLFLSCVTIIVGSLRKDGRLRHPHQRRDTAYAPDGFSYGGSFGELRSTCMEEFPPAFDFGSYLDTLSQVNIMYPDSPPRYDECVGPGATQIYIPTDDPPPYSLTDPCQRNEVSINISLEEEEAAAGTAGQAAHHATRLQGWQQPIPSIPSISLSSLPTEAAPRQKQNAAHKTSLSAPHRSQIKKEESFDTRGFFLGYPRPFQSLI</sequence>
</entry>
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    <accession>A0A8C2TT73</accession>
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        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
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            <taxon>Theropoda</taxon>
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            <taxon>Aves</taxon>
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            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
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        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TT73"/>
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        <property type="protein sequence ID" value="ENSCJPP00005017300.1"/>
        <property type="gene ID" value="ENSCJPG00005014146.1"/>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005017300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="90" mass="9702" checksum="944657ABD7B692B2" modified="2022-01-19" version="1">AALAHPHLHCSMGKGLSLLMACWEAHFKLFLISVGTGGVLQRCSSKRGTQPLWYGNAELALCPSAAETLSTPQHSQGVRCWKWAAGRSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TTC1</accession>
    <name>A0A8C2TTC1_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acyl-coenzyme A thioesterase 5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC107314866</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the C/M/P thioester hydrolase family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_015864627.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TTC1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005025596.1">
        <property type="protein sequence ID" value="ENSCJPP00005018367.1"/>
        <property type="gene ID" value="ENSCJPG00005014961.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107314866"/>
    <dbReference type="KEGG" id="cjo:107314866"/>
    <dbReference type="GeneTree" id="ENSGT01010000222336"/>
    <dbReference type="OrthoDB" id="9102350at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2240:FF:000001">
        <property type="entry name" value="acyl-coenzyme A thioesterase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000024">
        <property type="entry name" value="acyl-coenzyme A thioesterase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2240">
        <property type="entry name" value="Acyl-CoA thioester hydrolase/BAAT N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016662">
        <property type="entry name" value="Acyl-CoA_thioEstase_long-chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014940">
        <property type="entry name" value="BAAT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006862">
        <property type="entry name" value="Thio_Ohase/aa_AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042490">
        <property type="entry name" value="Thio_Ohase/BAAT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10824:SF17">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10824">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08840">
        <property type="entry name" value="BAAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04775">
        <property type="entry name" value="Bile_Hydr_Trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016521">
        <property type="entry name" value="Acyl-CoA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase" evidence="5">
        <location>
            <begin position="103"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="BAAT/Acyl-CoA thioester hydrolase C-terminal" evidence="6">
        <location>
            <begin position="292"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="320"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="414"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR016521-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005018367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="501" mass="54453" checksum="0E92960C75910FFD" modified="2022-01-19" version="1">MSPRSPCPGFSSPCVGSGTCTKSSSPNTNTAKRPGATGQMTALTACRQSSRCWQRCLSWPGLAPQPLQHGSPPHIPAVPSARGLASTATATIRFSPSTRSLFDEPLGIAVQGLGPRQQVTLRASLRDEAGELFEAHARYQAADDGELDLARCPALPGGSFSGLEPTGLLWALQPRKAFWRLVKKDVTTPFRLQLDVLDGHGDGPGRLLAQAQHERAFLRDGVRRVPVRDGRIRATLFLPPGQGPFPGVINMEGLGGGLCEHKASLLANHGFATLALAYYHFEDLVQKPTKLHLEYFEEAVNYMLQHTQVKGPGIGLLGFSKGGDLSLAMAAFLKNITAVATINSPVGNSAFPLCYKDKMIPPLICEEKYAKVYNNNIIDYSDAMCDPFKAPGNQSLIPIEKAEAHLLFIAGQDDHIVKSKYHATETYKYLQAQGKQNVQTLICPGAGHCIDPPFSPFYPIGNHPVFRKRAVLGGELTAYSKAQVRAWLQIQAFFHKHLNDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TTX0</accession>
    <name>A0A8C2TTX0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Brain-derived neurotrophic factor</fullName>
            <shortName evidence="5">proBDNF</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BDNF</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the NGF-beta family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015718943.1">
        <property type="nucleotide sequence ID" value="XM_015863457.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015718944.1">
        <property type="nucleotide sequence ID" value="XM_015863458.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015718945.1">
        <property type="nucleotide sequence ID" value="XM_015863459.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015718947.1">
        <property type="nucleotide sequence ID" value="XM_015863461.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TTX0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005026148.1">
        <property type="protein sequence ID" value="ENSCJPP00005018865.1"/>
        <property type="gene ID" value="ENSCJPG00005015313.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107314325"/>
    <dbReference type="CTD" id="627"/>
    <dbReference type="GeneTree" id="ENSGT00390000007725"/>
    <dbReference type="OrthoDB" id="8959386at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008021">
        <property type="term" value="C:synaptic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005163">
        <property type="term" value="F:nerve growth factor receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048668">
        <property type="term" value="P:collateral sprouting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050804">
        <property type="term" value="P:modulation of chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043524">
        <property type="term" value="P:negative regulation of neuron apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021675">
        <property type="term" value="P:nerve development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038180">
        <property type="term" value="P:nerve growth factor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048672">
        <property type="term" value="P:positive regulation of collateral sprouting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051965">
        <property type="term" value="P:positive regulation of synapse assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007416">
        <property type="term" value="P:synapse assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.90.10:FF:000002">
        <property type="entry name" value="Brain-derived neurotrophic factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020430">
        <property type="entry name" value="Brain-der_neurotrophic_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020408">
        <property type="entry name" value="Nerve_growth_factor-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002072">
        <property type="entry name" value="Nerve_growth_factor-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019846">
        <property type="entry name" value="Nerve_growth_factor_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11589:SF3">
        <property type="entry name" value="BRAIN-DERIVED NEUROTROPHIC FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11589">
        <property type="entry name" value="NERVE GROWTH FACTOR NGF -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00243">
        <property type="entry name" value="NGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001789">
        <property type="entry name" value="NGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01912">
        <property type="entry name" value="BDNFACTOR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00268">
        <property type="entry name" value="NGF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00140">
        <property type="entry name" value="NGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00248">
        <property type="entry name" value="NGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50270">
        <property type="entry name" value="NGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 5" id="KW-0339">Growth factor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034463533" description="Brain-derived neurotrophic factor" evidence="5">
        <location>
            <begin position="19"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Nerve growth factor-related" evidence="6">
        <location>
            <begin position="132"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="140"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="185"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="195"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001789-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005018865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="246" mass="27689" checksum="8CE6D580AE3A300A" modified="2022-01-19" version="1">MTILFLTMVISYFSCMKAAPMKEAGVRGQGSLAYPGLRTHGTLESLNGPNAGSRGLTSLADTFEHVIEELLDEDQDIQPSEENKDADLYTSRVMLSSQVPLEPPLLFLLEEYKNYLDAANMSMRVRRHSDPARRGELSVCDSTSEWVTAAEKKTAVDMSGATVTVLEKVPVPKGQLKQYFYETKCNPKGYTKEGCRGIDKRHWNSQCRTTQSYVRALTMDNKKRVGWRFIRIDTSCVCTLTIKRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TUI4</accession>
    <name>A0A8C2TUI4_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sorting nexin 20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">SNX20</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Early endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TUI4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005024521.1">
        <property type="protein sequence ID" value="ENSCJPP00005017609.1"/>
        <property type="gene ID" value="ENSCJPG00005014349.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901981">
        <property type="term" value="F:phosphatidylinositol phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07300">
        <property type="entry name" value="PX_SNX20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039937">
        <property type="entry name" value="SNX20/SNX21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20939">
        <property type="entry name" value="SORTING NEXIN 20, 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20939:SF1">
        <property type="entry name" value="SORTING NEXIN-20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="5" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="8">
        <location>
            <begin position="119"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="59"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="90"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005017609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="361" mass="41598" checksum="414D7EAAC7256CD8" modified="2022-01-19" version="1">MNCPPLKLCSPVVPFTFHETTDALRHVHREHFAMEQDPESTADRELLEAASTIATFSIAAPPDEEQSQPKAEISCEPSTENPEKDDLQDSKASLSPNSSMTTKELQEYWRNEKSQCRQVKLLFEIPSTRIVEHHLSKYVMYKIIILQTGSFDSNKSVIERRYSDFEKLHKNLLEDFSEEMEDMTFPKKALTGNFTDEIINERKLAFKDYLRLLYSMKYIRRSKKFIDFLTKPELQEAYGCLRGGQYNKALEILLEVIGLQERLTRGNPAATVPTLCAIVVCHKDLGNAASAFEYGEKALSLLCMRNSHKYYIPLLEAMITLAYELGKDFLSLQEKLEEWKAKKDPVRVFSLKELAVREYVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TV09</accession>
    <name>A0A8C2TV09_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Oxysterol-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">OSBP2</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the OSBP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015733862.2">
        <property type="nucleotide sequence ID" value="XM_015878376.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TV09"/>
    <dbReference type="Ensembl" id="ENSCJPT00005025357.1">
        <property type="protein sequence ID" value="ENSCJPP00005018203.1"/>
        <property type="gene ID" value="ENSCJPG00005014834.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107321457"/>
    <dbReference type="KEGG" id="cjo:107321457"/>
    <dbReference type="CTD" id="23762"/>
    <dbReference type="GeneTree" id="ENSGT00940000157987"/>
    <dbReference type="OrthoDB" id="14833at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015485">
        <property type="term" value="F:cholesterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13284">
        <property type="entry name" value="PH_OSBP_ORP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000074">
        <property type="entry name" value="Oxysterol-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000003">
        <property type="entry name" value="Oxysterol-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF194">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="6" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PH" evidence="12">
        <location>
            <begin position="125"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="358"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="407"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="331"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="104"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="361"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005018203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="861" mass="95537" checksum="EB6F798CF5B515E3" modified="2022-01-19" version="1">MGVEGLRSIPAPPPGGALASLRLPPYPTPSPRDVCAAPPHPGAGTEQRSVSGPRGRAAGSMGKAAALCSGSTRGLVSLLSAVPCLACHELPGSGRRAMSADTAGAGGRGGGGSGAAGGAAAVPGSDTYKGWLFKWTNYLKGYQRRWFVLSNGLLSYYRTQAEMAHTCRGTINLSTAHIDTEDSCNIVLSNGGRTYHLKASSEVERQRWVTALELAKAKAIRMRNNQSDDSGDEEPASQSDKSELHSTLKTLSSKVEDLSTCNDLIAKHGTALQRSLSELENLKLPAESGEKIKAVNERATLFRITSNAMINACRDFLDLAETHSRKWQRALQYEREQRIRLEETLEQLAKQHNSLERACRGAPGSTGSTGTAKGSVQSAKGEASDEDEETEYFDAMEDAPAFITVTADPKHHRRSGSNLSGASEGHPEDWNLEDSVFESSNQSSYNESCKDLLPKKRRRSRIPDKPNYSLNLWSIMKNCIGKELSKIPMPVNFNEPLSMLQRLTEDLEYHELLDKAVKCESSTEQMCFVAAFSVSSYSTTVHRTAKPFNPLLGETYELDRLEELGFRSLCEQVSHHPPAAAHHVSSKRGWTLWQEITIASKFRGKYLSIMPLGAIHLEFHSSGNHYVWRKVTSTVHNIIVGKLWIDQSGEIEIVNHKSKDKCQLKFTPYSYFSRDVPRKVTGVVSDADGKAHYVMSGTWDEKMECSKIVQSSHGSAGSEGKQKTVYQTLSPKVLWKKYPLPENAENMYYFSSLALTLNEPEERVAPTDSRLRPDQRLMESGRWDEANVEKQRLEEKQRAVRRRREAEAVEALEEGKDYEGYIPLWFERKVDPITGELICAYKGGYWEAKDKQDWSSCPDIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TV10</accession>
    <name>A0A8C2TV10_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">EF-hand calcium-binding domain-containing protein 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">EFCAB7</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TV10"/>
    <dbReference type="Ensembl" id="ENSCJPT00005024803.1">
        <property type="protein sequence ID" value="ENSCJPP00005017825.1"/>
        <property type="gene ID" value="ENSCJPG00005014490.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000015466"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060170">
        <property type="term" value="C:ciliary membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098797">
        <property type="term" value="C:plasma membrane protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042307">
        <property type="term" value="P:positive regulation of protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903569">
        <property type="term" value="P:positive regulation of protein localization to ciliary membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120229">
        <property type="term" value="P:protein localization to motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008589">
        <property type="term" value="P:regulation of smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000193">
        <property type="entry name" value="EF-hand calcium-binding domain-containing protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052266">
        <property type="entry name" value="Miro-EF-hand_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46819">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46819:SF1">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="233"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="64"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="130"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="324"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="348"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="365"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00069151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005017825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="759" mass="84779" checksum="321EAC8851C67C76" modified="2022-01-19" version="1">MNTLGTPRAVPFSFLPFPAHDGAKSRSRPSPHSAAPRPPFSSGAVMAPASRPPRAATYIMTAIRTAPAASTSPPRSVQRPNGAGWKLRGRDGAAKELRPSGPAGRDPCEGRDRGCSALLCPAAEGRFRLSRMASSPGRNASLADQNGTRSESSQAKKSQRAEEAIFYKSCRAAYLTVLKSSLENIKSKEQLTLVLQQAGRNPSQKTVNKYWTSQTTTLNFDDFCAILKEETPATKTELLEAFGRIDTDNTGYILHDELYKLLTTEGEKMTLDEVSAITKLPDFNCNGKLDYKKFCDLYVTTSEQCCRAALERLEADNRLRHRQFGSEAETSPEGITLPVSKPALKTLRKTDHKPAPTKGDSRTPSRPAQSCKASSSSTISMCASSNRSTNLIEPSTMKEWQCAQSKGCFYLEEDGEIVSHKYRLHLPQRSTVCITIKPLRLRQIEGRSCHWLSVDTVLYVLKENETQENLQLMCFTDQQNKEMFGWKGELPSGVYWLLPFTTGCRLKKVKTEITGEAKLVYRDEDGELALTKEFRTALLDIFETIDLDGNGLLSLEEYNFFELRTSGETCDEEVWAVCKDNFDMKKNELTRQGFMDLNLMEANDREGDPSDLWVTLLSLGYNKALEMTEACPFVIDIYAEKCKPRIKAVYLEAGGWQLNRAICKSVVNNGDAKVMDGCENIIVYTQRTGMRITSVIENKSDNKVIVHVNNEQSRNCLSNRGLAVFAVEVAPKSMMVSQHVMPLNEQEEWLYNCVHSLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TV29</accession>
    <name>A0A8C2TV29_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Forkhead box D3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">FOXD3</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015726246.1">
        <property type="nucleotide sequence ID" value="XM_015870760.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TV29"/>
    <dbReference type="Ensembl" id="ENSCJPT00005024800.1">
        <property type="protein sequence ID" value="ENSCJPP00005017822.1"/>
        <property type="gene ID" value="ENSCJPG00005014487.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107317743"/>
    <dbReference type="KEGG" id="cjo:107317743"/>
    <dbReference type="CTD" id="27022"/>
    <dbReference type="GeneTree" id="ENSGT00940000161645"/>
    <dbReference type="OrthoDB" id="5402974at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd20046">
        <property type="entry name" value="FH_FOXD1_D2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000016">
        <property type="entry name" value="Forkhead box protein I1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050211">
        <property type="entry name" value="FOX_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829">
        <property type="entry name" value="FORKHEAD BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829:SF361">
        <property type="entry name" value="FORKHEAD BOX PROTEIN D4-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="9">
        <location>
            <begin position="120"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="7">
        <location>
            <begin position="120"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005017822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="397" mass="40903" checksum="899D0CB06D0FD8A0" modified="2022-01-19" version="1">MTLSGGGSDMSGQTALAAEDVDIDVVGEGDDAPGKDGDGEARSPAALPRLPLDEAAEPGEPGAGGESGSSGSGSPAPAGPEGGRGGGGGGGGEEGASGGGAAAAAAAAAGQSKPKSSLVKPPYSYIALITMAILQSPKKRLTLSEICEFISGRFPYYREKFPAWQNSIRHNLSLNDCFVKIPREPGNPGKGNYWTLDPESEDMFDNGSFLRRRKRFKRHQQEHLRDQTALMMQGFGAYGLAGPYGRPYGLPPGAYPHPAALQYPYIPPVGPMLPPAVPLLPSGELSRKAFNAQLGPSLQLQLSSLGAAGSIVKSEPSSRPSFSIENIIGGPAVSSAPSAQTFLRPPVTVQSGLVAHQPLALARTTAAIAPILSVPTNIIAGQFLQPPAAVQAKWPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TVD4</accession>
    <name>A0A8C2TVD4_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Heterochromatin-associated protein MENT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC107309562</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the serpin family. Ov-serpin subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015709959.1">
        <property type="nucleotide sequence ID" value="XM_015854473.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032298371.1">
        <property type="nucleotide sequence ID" value="XM_032442480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TVD4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005026646.1">
        <property type="protein sequence ID" value="ENSCJPP00005019207.1"/>
        <property type="gene ID" value="ENSCJPG00005015612.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107309562"/>
    <dbReference type="GeneTree" id="ENSGT00940000165915"/>
    <dbReference type="OrthoDB" id="671595at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02058">
        <property type="entry name" value="serpinB_MENT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.39.10:FF:000050">
        <property type="entry name" value="Heterochromatin-associated protein MENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.497.10:FF:000001">
        <property type="entry name" value="Serine protease inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461:SF175">
        <property type="entry name" value="SERPIN B10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00093">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serpin" evidence="6">
        <location>
            <begin position="13"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005019207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="410" mass="47036" checksum="BEC75A2504A6F5BB" modified="2022-01-19" version="1">MEQVSASIGSFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLGAKGNTAREMAEVLHFTEAAGAESSSVARPSRGRPKRRRMDPEHEQAENIHTGFKELLAAFNKPRNTYSLRSANRIYVEKTYPLLPTYIQLNKKYYKAEPHKVNFKTAPEQTRKEINTWVEKQTESKIKDLLSSDDVTNTTRLILVNAIYFKAEWEVQFQAGHTSMQPFRLSKNKSKPVKMMYMRNTFPVLIMEKMNFKMIELPYVKRELSMFILLPDDIRDGTTGLEQLERELTYEKLSEWADSKKMTETLVDLHLPKFSLEDKYDLHDTLRNMGMTSAFTSKADFRGMTAKKDLFISKVAHQSFVAVDEKGTEAAAATAVIVTVTATAINIALKFKADHPFHFFIRHNKSKTILFFGRFCCPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TVZ1</accession>
    <name>A0A8C2TVZ1_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc finger protein RFP-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC107321537</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015734022.1">
        <property type="nucleotide sequence ID" value="XM_015878536.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TVZ1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005026929.1">
        <property type="protein sequence ID" value="ENSCJPP00005019447.1"/>
        <property type="gene ID" value="ENSCJPG00005015753.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107321537"/>
    <dbReference type="KEGG" id="cjo:107321537"/>
    <dbReference type="GeneTree" id="ENSGT00940000158668"/>
    <dbReference type="OrthoDB" id="9049620at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12888">
        <property type="entry name" value="SPRY_PRY_TRIM7_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000004">
        <property type="entry name" value="Butyrophilin subfamily 1 member A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003879">
        <property type="entry name" value="Butyrophylin_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006574">
        <property type="entry name" value="PRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050143">
        <property type="entry name" value="TRIM/RBCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24103">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13765">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15227">
        <property type="entry name" value="zf-C3HC4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01407">
        <property type="entry name" value="BUTYPHLNCDUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00589">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="16"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="6">
        <location>
            <begin position="84"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="7">
        <location>
            <begin position="279"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005019447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="495" mass="56346" checksum="260198813AE05CC3" modified="2022-01-19" version="1">MSAPSPLHTLHIESSCSICLCYFHDPVSIPCGHNFCRGCITRCWAGLDSHFPCPQCRKITSQPSFRPSIELANIASIARQLRAQCNAWCNQHPEGSRLFCKEDGEPVCAQCDGFRDHGGHTVLPAQQAAREYKEEIQARLRASKEEREKYLESRKTGGRTGLYLDQTKKEGKRIVCEFDQLRQFLKEKERFLLLQLSDLDRTVTKVQEDAVTKVLEEISHLDTLIWEMEGKFQQPDSKFLLDIRRLLNSCEMMKFNPPAEISPILERRLEDFLQKNVAVRRTLRQCQDSLMFQLQEPANVTMDPTTAHPNLYLSEDRKQVRGQLIPQDLPDNPERFSFETCVLGCQGFTSGRHFWEVDVGQGGVWALGAARASIKRKGPMSFSPKEGVWALEAYHSLTSPRANLRLNALPRRIRVSLDYEGGRVAFFSSDDDTPILVYTRASFNGERVLPWFKIGMGARLQEITPNSPLEEQTASGQLMSHLDWVGFRSPLKICP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TW41</accession>
    <name>A0A8C2TW41_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine/arginine repetitive matrix 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">SRRM4</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TW41"/>
    <dbReference type="Ensembl" id="ENSCJPT00005024896.1">
        <property type="protein sequence ID" value="ENSCJPP00005017907.1"/>
        <property type="gene ID" value="ENSCJPG00005014550.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00730000111247"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042551">
        <property type="term" value="P:neuron maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007605">
        <property type="term" value="P:sensory perception of sound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029360">
        <property type="entry name" value="SRRM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052109">
        <property type="entry name" value="SRRM_Domain-Containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34755">
        <property type="entry name" value="SERINE/ARGININE REPETITIVE MATRIX PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34755:SF1">
        <property type="entry name" value="SERINE_ARGININE REPETITIVE MATRIX PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15230">
        <property type="entry name" value="SRRM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/arginine repetitive matrix protein C-terminal" evidence="2">
        <location>
            <begin position="247"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="167"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="305"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="375"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005017907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="386" mass="42235" checksum="887E968B7A4A0AEE" modified="2022-01-19" version="1">MTNRALQELEGKAFPKHESLSLLLFLPARGLNISQSGSSADLFTKTDSPPGHLASQNGECHEYDSGNDTSSPPSTQTSSSRSKDSQEKRSIAHDGFGPAFSSGKPKVANGDNSSDSGNSFTSCFSQTKATASENLSPDAQGQDQRGCLSSCPSCSEEKKRSVPPSPARSSPLRPCPRSESCSSTGRSSPGSSRSCSSPRRASPRYSRSRSCSSGKRSSSRSPSYSSKSCKKSPGSRSSKTRRSPSYSHYSPTRDREHKHSSSEKESHRQRDRQRRRSYSPLRKRRRDSPSHLEARRITSARKRPIPYYRPSPSSSSSASSYSSWYSSLSRSPSRSRSYSSHRTSRSRSWSSSSTEGRSRSRSSDPRSSRSRSRSCDSGGSSDSLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TWB0</accession>
    <name>A0A8C2TWB0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Mediator of RNA polymerase II transcription subunit 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Mediator complex subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">MED6</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8 10">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Mediator complex subunit 6 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015720128.1">
        <property type="nucleotide sequence ID" value="XM_015864642.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TWB0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005025619.1">
        <property type="protein sequence ID" value="ENSCJPP00005018389.1"/>
        <property type="gene ID" value="ENSCJPG00005014977.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107314881"/>
    <dbReference type="KEGG" id="cjo:107314881"/>
    <dbReference type="CTD" id="10001"/>
    <dbReference type="GeneTree" id="ENSGT00390000017666"/>
    <dbReference type="OrthoDB" id="344220at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001223">
        <property type="term" value="F:transcription coactivator binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035019">
        <property type="term" value="P:somatic stem cell population maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.580:FF:000001">
        <property type="entry name" value="Mediator of RNA polymerase II transcription subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.580">
        <property type="entry name" value="Mediator complex, subunit Med6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007018">
        <property type="entry name" value="Mediator_Med6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016820">
        <property type="entry name" value="Mediator_Med6_met/pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038566">
        <property type="entry name" value="Mediator_Med6_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13104">
        <property type="entry name" value="MED-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04934">
        <property type="entry name" value="Med6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF023869">
        <property type="entry name" value="Mediator_MED6_meta/pln"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0010">Activator</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="189"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR023869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005018389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="246" mass="28316" checksum="15BCD98FB3E3DA52" modified="2022-01-19" version="1">MAAVDVRDNLLGISWVDSAWIPILNNGSVLDYFSERSNPFYDRTCNNEVVKMQRMTLDHLNQMVGVEYILLHAQEPILFIIRKQQRQSPTQVIPLADYYIIAGVIYQAPDLGSVINSRVLTAVHGIQSAFEEAMSYCRYHPSKGYWWHFKDQEEREKAKPKAKKKEEPSSIFQRQRVDALLLDLRQKFPPKFVQQKPGEKPIPVDQIKKEPEPAPEAVKTEEKETVKNAQQSAAAKGPPEKRMRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TYZ0</accession>
    <name>A0A8C2TYZ0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NIF3-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">NIF3L1</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP cyclohydrolase I type 2/NIF3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TYZ0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005025985.1">
        <property type="protein sequence ID" value="ENSCJPP00005018720.1"/>
        <property type="gene ID" value="ENSCJPG00005015111.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000003590"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061629">
        <property type="term" value="F:RNA polymerase II-specific DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1390.30">
        <property type="entry name" value="NIF3 (NGG1p interacting factor 3)-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002678">
        <property type="entry name" value="DUF34/NIF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017222">
        <property type="entry name" value="DUF34/NIF3_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036069">
        <property type="entry name" value="DUF34/NIF3_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00486">
        <property type="entry name" value="YbgI_SA1388"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799">
        <property type="entry name" value="NGG1 INTERACTING FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799:SF13">
        <property type="entry name" value="NIF3-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01784">
        <property type="entry name" value="DUF34_NIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037490">
        <property type="entry name" value="UCP037490_NIF3_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102705">
        <property type="entry name" value="NIF3 (NGG1p interacting factor 3)-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="387"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="391"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR602678-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005018720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="425" mass="46673" checksum="A02BC126AE03105B" modified="2025-10-08" version="2">MPGTLLAPGELDKAIHRQWNTTCITGTASVSRPSPALLPSSSSFSPRRFRMLLCLLCRPLHCIRAAGRPPSRSLMDLRELVAALNDFASPSLAESWDNVGLLVEPSPPHAVRTLLLTNDLTEQVMEEAVQKNADLILSYHPPIFAPLKRVTWRTWKERLVVRALEHRIGIYSPHTAYDAVPHGVNTWLSKGLGACTSVPLHPSTAPSHPTEGTHQVEFCADSTEQLDTVLSKIKDIPEIFSPNTSFLRADREEQTRVSLNCSQKALLEVVALLSQNSLLYHKTEILLLQKPLLPHTGMGRLCTLSEPASLSDIIERIKSHLKLPHVRLAMGTGKTLDSPVKKAALCAGSGSSVLKGTEADLYLTGEMSHHDVLDAVANGISVILCEHSNTERGFLSELRDTLTAHLQNKVNIIMSEKDRDPLQVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TZ70</accession>
    <name>A0A8C2TZ70_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">PTPRR</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
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            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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</entry>
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            <taxon>Theropoda</taxon>
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            <taxon>Aves</taxon>
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            <taxon>Galloanserae</taxon>
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            <taxon>Coturnix</taxon>
        </lineage>
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                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027095">
        <property type="entry name" value="Golgin-45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013183">
        <property type="entry name" value="Hsk3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13066">
        <property type="entry name" value="BASIC LEUCINE ZIPPER NUCLEAR FACTOR 1 BLZF1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13066:SF2">
        <property type="entry name" value="GOLGIN-45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08227">
        <property type="entry name" value="DASH_Hsk3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="120"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="181"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005021886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="395" mass="44010" checksum="FBA76CA14471CF2A" modified="2022-01-19" version="1">MTSVEKVDYASSPIRGPGDGMETEQTDEPVEVSSGASTTNHHVHHSPQKKTASSLSPGVLQLGQIHADKSVEVEAVRILVPKAAITHVVATKNAKVAKSAGHKGDAFHQSDGTADPKKEQTELKNAIEKLKNSEKRLLQDKEGLSNQLRIQTEVNRELKKLLVASVGDDLQYHFERMAREKNQLILENEVLGRNLSQLSEQLERMSIQCDVWRSKFLASRVMADELTNTRAILQRQTRDAQSAIQDLLNERDQFRQEMIHTQKLLEELMVSLQWGRQQTYYPSAQPYTTTELAAVNCKLAKAVSSHLLGNVGSSSPKKTSTAVEFCNTPAEKMAERVLHVLDPAARTETSAEASFSETSSFLSTKKNIGRFHPYTRYEDITFNCCDHCQGELIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U3E9</accession>
    <name>A0A8C2U3E9_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Complex I-B15</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">NADH-ubiquinone oxidoreductase B15 subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">NDUFB4</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Complex I is composed of 45 different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFB4 subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2U3E9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005029798.1">
        <property type="protein sequence ID" value="ENSCJPP00005021731.1"/>
        <property type="gene ID" value="ENSCJPG00005017357.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000007133"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009866">
        <property type="entry name" value="NADH_UbQ_OxRdtase_NDUFB4_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15469:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15469">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B15 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07225">
        <property type="entry name" value="NDUF_B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="8 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005021731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="155" mass="18055" checksum="1442D6EB49FDD7A7" modified="2022-01-19" version="1">MASGPRRTAAEEYRPNRFVSLPPELDPATYDSSPEKRRAEAERLAIRARLKRQYLLQLNNPKPPAIIEDPALLRWDYARTHNVYPNFRPTPKTSFLGAVFAIGPILFWIAAFKTERDYKEKLIREELFSKGLLQTILQNTTVGHCKRRSINTWRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U3Z9</accession>
    <name>A0A8C2U3Z9_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Bromodomain adjacent to zinc finger domain protein 1A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">BAZ1A</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WAL family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSCJPT00005030391.1">
        <property type="protein sequence ID" value="ENSCJPP00005022130.1"/>
        <property type="gene ID" value="ENSCJPG00005017586.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158135"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016590">
        <property type="term" value="C:ACF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008623">
        <property type="term" value="C:CHRAC"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005721">
        <property type="term" value="C:pericentric heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045740">
        <property type="term" value="P:positive regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031445">
        <property type="term" value="P:regulation of heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05504">
        <property type="entry name" value="Bromo_Acf1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15627">
        <property type="entry name" value="PHD_BAZ1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000029">
        <property type="entry name" value="Bromodomain adjacent to zinc finger domain protein 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000300">
        <property type="entry name" value="Bromodomain adjacent to zinc finger domain protein 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037325">
        <property type="entry name" value="Acf1_Bromo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047171">
        <property type="entry name" value="BAZ1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018501">
        <property type="entry name" value="DDT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028942">
        <property type="entry name" value="WHIM1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028941">
        <property type="entry name" value="WHIM2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013136">
        <property type="entry name" value="WSTF_Acf1_Cbp146"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46510">
        <property type="entry name" value="BROMODOMAIN ADJACENT TO ZINC FINGER DOMAIN PROTEIN 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46510:SF1">
        <property type="entry name" value="BROMODOMAIN ADJACENT TO ZINC FINGER DOMAIN PROTEIN 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02791">
        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10537">
        <property type="entry name" value="WAC_Acf1_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15612">
        <property type="entry name" value="WHIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15613">
        <property type="entry name" value="WSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00571">
        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50827">
        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51136">
        <property type="entry name" value="WAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="10 18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="WAC" evidence="23">
        <location>
            <begin position="22"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="DDT" evidence="22">
        <location>
            <begin position="420"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="21">
        <location>
            <begin position="1150"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="20">
        <location>
            <begin position="1454"/>
            <end position="1524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="682"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="857"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1204"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1280"/>
            <end position="1351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1391"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="322"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="682"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="701"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="713"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="725"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="753"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="1215"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="1239"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="1290"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1302"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="1313"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="1332"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1421"/>
            <end position="1432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00068253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005022130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1562" mass="179618" checksum="34D5CCBE6C297845" modified="2022-01-19" version="1">MPLLHRKPFVREKPPADLRPDERVFYCRVTNEIFRDYDDFFERTILCNSLVWSCAVTGKPGLTYQEALESEKKARHNLQSFPEALIIPVLYLATLTHRSRLHEICDEIFAYVKDRYFVGETVEMIRNNGERLQCQVLEVIPPAHHNGMANGHVSSADGETIVISDSDDSETHNSSAQNGKKKAIIDPSLFKYKVQPVKKELYESVIVKASQLSRRKHLFSRDRLKLFLKQHCEPHDGVIKTKATSIAKYNLAEQNYSYFFPDDPPTFVFSPASRRRGRPPKRASISHVSHDNIFNSCEIPEQLEFKIDKKFLFFSSYVAFEKARLKREKANAIEARKREKEDKEKKKEELKKIVEEERMKRKEEKERLKIEKEKEREKLREEKRKYVEYLKQWSKPREDMECDDLKELPVPMPVKTRLPPEIFGDALMVLEFLYAFGELFDLQDEFPEGVTLEVLEEALVGNDTEGPLCELLFFFLTAIFQAMAEEEEEVAKDQIADAETKDLTEALDEDADPTKSALSAVATLAAAWPQLHQGCNLKNLDLDSCTLSEILRLHILASGADVTSANAKYRYQKRGGFDATDDACMELRLSNPGLLKKLSSTSVYDLLPGEKMKILHALCGKLLTLVSTRDFIEDSVDVLRQAKQEFRELKAEQHRKEREAAAARIRKRKEERLKEQELKMKEKQEKLKEEEQRNPAVEVSVGEEEREDLDTSTESKENERKEPEIDTVTEDEEELGPNKKGRRGRRGQNGYKEFTRQEDASEKSEPLTAEDEEALKQEQQKKEKELLEKIQNATACTNITPLGRDRLYRRYWIFPSVPGLFIEEDYSGLTEDMLLPRTSSFQNSVQSCTNEPQVFSKTGESLKSSESTSNVDQDSHTSVVVEVPRPVYKPNRWCFYSSREQLDQLLEALNSRGHRESALKETLLQEKNRIYEQLSSFPVEKFHIPDKPQSDVRPPPPVRGRMQNAHDASQISAEKQLEMRLRDFLLDIEDRIYQGTLGAIKVTDRQSWRAALEHGWYEFLNDENKENGVIKTVNEESEEMETDDQDKFMVKDRLVGLKTEAPSAASTSTSTPQPVNNVVHCLASALLQIEQGIERRFLKAPLDASDGGRSYKTVLDRWRESLLASTSLSQVFLHLSTLDRSVIWSKSILNARCKVCRKKGDAESMVLCDGCDRGYHTYCIRPKLKIIPEGDWFCPECRPKQRSRRLSSRQRPSVESDEEMAEQIEGEEEASYDEMRQSEEEDYEEEHEEEDESQEEDEMSPSKHGRPQVKFPLKMRAAKLNNPFSSRNIQRQARYASRSQQNTPKQAGSSSRVTRRGLRKVKSAPPSVTKPTLRLSSRTTRQSQSSLQADVFVELLSPRRRRRGKKNADDNTLENSSDSLGFRIVETSDSNERVRRYPVAAPKLSLPVSEPKRRGRKRQSTESSPQTSLNRRSSGRQGGVHELSAFEQLVVELVRHDDSWPFMKLVSKIQVPDYYDIIKKPIALNIIREKVNKCEYKLASEFIEDIELMFSNCFEYNPRNTSEAKAGTRLQAFFHIQAQKLGLPITSGNVDHAAPVAKKSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U4N5</accession>
    <name>A0A8C2U4N5_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LanC-like protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LANCL3</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LanC-like protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015739934.1">
        <property type="nucleotide sequence ID" value="XM_015884448.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U4N5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005029023.1">
        <property type="protein sequence ID" value="ENSCJPP00005021099.1"/>
        <property type="gene ID" value="ENSCJPG00005016902.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107324430"/>
    <dbReference type="KEGG" id="cjo:107324430"/>
    <dbReference type="CTD" id="347404"/>
    <dbReference type="GeneTree" id="ENSGT00530000063186"/>
    <dbReference type="OrthoDB" id="10257263at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031179">
        <property type="term" value="P:peptide modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04794">
        <property type="entry name" value="euk_LANCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000012">
        <property type="entry name" value="LanC-like protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007822">
        <property type="entry name" value="LANC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020464">
        <property type="entry name" value="LanC-like_prot_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12736">
        <property type="entry name" value="LANC-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12736:SF7">
        <property type="entry name" value="LANC-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05147">
        <property type="entry name" value="LANC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01951">
        <property type="entry name" value="LANCEUKARYTE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01950">
        <property type="entry name" value="LANCSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM01260">
        <property type="entry name" value="LANC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158745">
        <property type="entry name" value="LanC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00074153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR607822-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005021099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="416" mass="45680" checksum="1C90927399D062CA" modified="2022-01-19" version="1">MASQRCFANRFDDYAGSLAAAPDKEAAVPLVTATIERILKELPPLGGGAAGGPRCCQGGLYGGVAGVAYMLYHVAQCPLFAPSREAYLRAARRVVDACLRYQEAGGEADADTRAAFLLGGAGVYAVAALVYRALGLPDFARPLGKFRELSEVCAPLSFLECGSDELFVGRAGYLCAALVLKQRLGMEVLTPAQIKSICLAILESGKQYAVKKRKPFPLMYSYYGTEYLGAAHGLSSILQMLLSYFEYLQPADQELVWQSVDFLMDQEQNSNWPPELGETIERENELVHWCHGAPGIAYLFAKAYLVSKKPQYLDTCIRCGELTWQKGLLKKGPGICHGVAGSAYVFLLLYRLTGNSKYIYRAQRFAEFLFTEEFKAGSRALESVYSLYEGFSGTVCFLTDLLQPNQAEFPLFSVFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U5Z2</accession>
    <name>A0A8C2U5Z2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="40">ATP-dependent DNA/RNA helicase DHX36</fullName>
            <ecNumber evidence="10">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="42">DEAD/H box polypeptide 36</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="41">MLE-like protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="46" type="primary">DHX36</name>
    </gene>
    <organism evidence="46 47">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="46" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="46" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="46" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="39">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell projection</location>
            <location evidence="7">Axon</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cell projection</location>
            <location evidence="4">Dendrite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Chromosome</location>
            <location evidence="9">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Stress granule</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
            <location evidence="8">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus speckle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Perikaryon</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="10"/>
    <dbReference type="RefSeq" id="XP_015727668.1">
        <property type="nucleotide sequence ID" value="XM_015872182.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U5Z2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005031283.1">
        <property type="protein sequence ID" value="ENSCJPP00005022823.1"/>
        <property type="gene ID" value="ENSCJPG00005018141.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107318411"/>
    <dbReference type="KEGG" id="cjo:107318411"/>
    <dbReference type="CTD" id="170506"/>
    <dbReference type="GeneTree" id="ENSGT00940000156903"/>
    <dbReference type="OrthoDB" id="5600252at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043204">
        <property type="term" value="C:perikaryon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051880">
        <property type="term" value="F:G-quadruplex DNA binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002151">
        <property type="term" value="F:G-quadruplex RNA binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042826">
        <property type="term" value="F:histone deacetylase binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048027">
        <property type="term" value="F:mRNA 5'-UTR binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061158">
        <property type="term" value="P:3'-UTR-mediated mRNA destabilization"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903843">
        <property type="term" value="P:cellular response to arsenite ion"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034644">
        <property type="term" value="P:cellular response to UV"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001503">
        <property type="term" value="P:ossification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043123">
        <property type="term" value="P:positive regulation of canonical NF-kappaB signal transduction"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051891">
        <property type="term" value="P:positive regulation of cardioblast differentiation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000767">
        <property type="term" value="P:positive regulation of cytoplasmic translation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901534">
        <property type="term" value="P:positive regulation of hematopoietic progenitor cell differentiation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032727">
        <property type="term" value="P:positive regulation of interferon-alpha production"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031442">
        <property type="term" value="P:positive regulation of mRNA 3'-end processing"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002735">
        <property type="term" value="P:positive regulation of myeloid dendritic cell cytokine production"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900153">
        <property type="term" value="P:positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:1904358">
        <property type="term" value="P:positive regulation of telomere maintenance via telomere lengthening"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060261">
        <property type="term" value="P:positive regulation of transcription initiation by RNA polymerase II"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045995">
        <property type="term" value="P:regulation of embryonic development"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006359">
        <property type="term" value="P:regulation of transcription by RNA polymerase III"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043330">
        <property type="term" value="P:response to exogenous dsRNA"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090669">
        <property type="term" value="P:telomerase RNA stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd17981">
        <property type="entry name" value="DEXHc_DHX36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000002">
        <property type="entry name" value="Putative ATP-dependent RNA helicase DHX36"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.40.50.300:FF:000670">
        <property type="entry name" value="Putative ATP-dependent RNA helicase DHX36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000739">
        <property type="entry name" value="Putative ATP-dependent RNA helicase DHX36"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
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    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
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        <property type="entry name" value="HA2_WH"/>
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    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
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    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059023">
        <property type="entry name" value="RNA_hel_CTD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF237">
        <property type="entry name" value="ATP-DEPENDENT DNA_RNA HELICASE DHX36"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26026">
        <property type="entry name" value="RNA_hel_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="30" id="KW-0007">Acetylation</keyword>
    <keyword evidence="35" id="KW-0010">Activator</keyword>
    <keyword evidence="32" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="24" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="38" id="KW-0966">Cell projection</keyword>
    <keyword evidence="12" id="KW-0158">Chromosome</keyword>
    <keyword evidence="14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="21" id="KW-0221">Differentiation</keyword>
    <keyword evidence="33" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="23" id="KW-0347">Helicase</keyword>
    <keyword evidence="22" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="27" id="KW-0391">Immunity</keyword>
    <keyword evidence="17" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="25" id="KW-0460">Magnesium</keyword>
    <keyword evidence="18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="34" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="37" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="47" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="19" id="KW-0677">Repeat</keyword>
    <keyword evidence="15" id="KW-0678">Repressor</keyword>
    <keyword evidence="28" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="29" id="KW-0779">Telomere</keyword>
    <keyword evidence="36" id="KW-0804">Transcription</keyword>
    <keyword evidence="31" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="26" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="11" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="202"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="45">
        <location>
            <begin position="462"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="43">
        <location>
            <begin position="1"/>
            <end position="83"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="43">
        <location>
            <begin position="96"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="43">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="43">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="43">
        <location>
            <begin position="67"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="43">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00004489"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="35">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="36">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="37">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="38">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="39">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="40">
        <source>
            <dbReference type="ARBA" id="ARBA00069921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="41">
        <source>
            <dbReference type="ARBA" id="ARBA00076143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="42">
        <source>
            <dbReference type="ARBA" id="ARBA00083335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="43">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="44">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="45">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="46">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005022823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="47">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="993" mass="113089" checksum="FFE2A4C9C49859BF" modified="2022-01-19" version="1">MSYEQRRDWGRGRGRGGDGGSSAASSGGGGHGGHGGHGGRGGGRGRHPSHLKGREIGLWYARKQGQKSKETDRQQRAVVRMDERREEQIVQLLNAVQPRAEKEQEAMSWWSGDEEGHTPEQPPKVKPGAEKGEKAPVKRQPGLEKTFLDQDVEYLFERNDQDADLDEQLKEDLRKKKSDPRYIEMQRFREKLPSYGMRQELVNLINNNRVTVISGETGCGKTTQVTQFILDDYIERGKGSTCRIVCTQPRRISAISVAERVAAERAEACGNGKSTGYQIRLQSRLPRKQGSILYCTTGIVLQWLQSDKHLSSISHVVLDEIHERNLQSDVLMSIIKDLLNVRLDLKVILMSATLNAEKFSEYFDNCPMIHIPGFTFPVVEYLLEDVIEKLRYTPENTDRRPRWKKGFMQGHVSRPEKEEKEEIYRERWPEYLRQLRGRYSAGTIDALEMMDDDKVDLDLIAALIRHIVLEEEDGAILVFLPGWDNISTLHDLLMSQVMFKSDRFIIIPLHSLMPTVNQTQVFKKTPPGVRKIVIATNIAETSITIDDVVFVIDGGKIKETHFDTQNNISTMAAEWVSKANAKQRKGRAGRVQPGHCYHLYNGLRASLLDDYQLPEILRTPLEELCLQIKILKLGGIAYFLSKLMDPPSRDAVMLAINHLMELNALDRQEELTPLGVHLARLPVEPHIGKMILFGALFCCLDPVLTIAASLSFKDPFVIPLGKEKVADARRKELSKNTKSDHLTVVNAFTGWEETRRRGFRTEKDYCWEYFLSPNTLQMLHNMKGQFAEHLLAAGFVNSRDPKDPKSNTNSDNEKLLKAVICAGLYPKVAKIRPSFSKKRKMVKVCTKTDGTVNIHPKSVNVEETEFHYNWLVYHLKMRTSSIYLYDCTEVSPYCLLFFGGDISIQKDKDQDTIAVDEWIVFQSPARIAHLVKNLRRELDDLLQEKIENPHPVDWNDTKCRDTAVLTAIIDLITTQENESARNYAPRFQGERCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U7W9</accession>
    <name>A0A8C2U7W9_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TM100 protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2U7W9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005031870.1">
        <property type="protein sequence ID" value="ENSCJPP00005023227.1"/>
        <property type="gene ID" value="ENSCJPG00005018458.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00960000188184"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071773">
        <property type="term" value="P:cellular response to BMP stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032536">
        <property type="entry name" value="TMEM100"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16100">
        <property type="entry name" value="PHOSPHOINOSITIDE-INTERACTING PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16100:SF5">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16311">
        <property type="entry name" value="TMEM100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005023227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="142" mass="15088" checksum="BBB322F283CBFC3C" modified="2022-01-19" version="1">VAEGAADASRGACSPPTPRRLHQNGMLGEFIVNKKTGLPLNAATDSTATLNKLALATGGTEKSWYRCIFPFGIVSVVVGVAATCITFTINGPQMDIAKVVSVATLIFGLGLLVAAYVCWRAKRERQQRRQRQEPGSAEQGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U9L7</accession>
    <name>A0A8C2U9L7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Neurogenic differentiation factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">NEUROD4</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_032297001.1">
        <property type="nucleotide sequence ID" value="XM_032441110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U9L7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005034797.1">
        <property type="protein sequence ID" value="ENSCJPP00005025595.1"/>
        <property type="gene ID" value="ENSCJPG00005020082.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107325700"/>
    <dbReference type="KEGG" id="cjo:107325700"/>
    <dbReference type="CTD" id="58158"/>
    <dbReference type="GeneTree" id="ENSGT00940000160217"/>
    <dbReference type="OrthoDB" id="10039134at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome LGE22C19W28_E50C23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070888">
        <property type="term" value="F:E-box binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061564">
        <property type="term" value="P:axon development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043010">
        <property type="term" value="P:camera-type eye development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19721">
        <property type="entry name" value="bHLH_TS_NeuroD4_ATOH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000006">
        <property type="entry name" value="Neurogenic differentiation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050359">
        <property type="entry name" value="bHLH_transcription_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022575">
        <property type="entry name" value="NeuroD_DUF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016637">
        <property type="entry name" value="TF_bHLH_NeuroD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19290">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19290:SF86">
        <property type="entry name" value="NEUROGENIC DIFFERENTIATION FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12533">
        <property type="entry name" value="Neuro_bHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015618">
        <property type="entry name" value="bHLH_NeuroD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="1 9" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="2 9" id="KW-0221">Differentiation</keyword>
    <keyword evidence="5 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 9" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="11">
        <location>
            <begin position="87"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="26"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR015618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005025595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="330" mass="36825" checksum="4CD94D8DD7DEEC69" modified="2022-01-19" version="1">MTKTYTKPKEMAELVGTQSWMDEALSSKDELKAENGRQGTFGLVPGLNEEHDSIEEEEEEEDDGEKPKRRGPKKKKMTKARLERFRARRVKANARERTRMHGLNDALDNLRRVMPCYSKTQKLSKIETLRLARNYIWALSEVLETGQTPEGKSFVEMLCKGLSQPTSNLVAGCLQLGPQTLFLDKHEEKTPGCESAISSHSFTYQSPGLPSPPYGSMETHLLHLKPPAFKSLVDASFGNPPDCTTPPYEGPLTPPLSISGNFSLKQDGSPDLDKPYAFMAHYPSVSLAGAHGHPTHFQNAVPRYEIPIDMSYESYPHHVAGPQLNAIFNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UB85</accession>
    <name>A0A8C2UB85_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Integral membrane protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">ITM2B</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endosome membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Membrane</location>
            <topology evidence="14">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the ITM2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015707279.1">
        <property type="nucleotide sequence ID" value="XM_015851793.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UB85"/>
    <dbReference type="Ensembl" id="ENSCJPT00005034263.1">
        <property type="protein sequence ID" value="ENSCJPP00005025165.1"/>
        <property type="gene ID" value="ENSCJPG00005019774.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107308150"/>
    <dbReference type="KEGG" id="cjo:107308150"/>
    <dbReference type="CTD" id="9445"/>
    <dbReference type="GeneTree" id="ENSGT00950000183115"/>
    <dbReference type="OrthoDB" id="9982095at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070062">
        <property type="term" value="C:extracellular exosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030660">
        <property type="term" value="C:Golgi-associated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001540">
        <property type="term" value="F:amyloid-beta binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042985">
        <property type="term" value="P:negative regulation of amyloid precursor protein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007084">
        <property type="entry name" value="BRICHOS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040145">
        <property type="entry name" value="ITM2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10962:SF4">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10962">
        <property type="entry name" value="INTEGRAL TRANSMEMBRANE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04089">
        <property type="entry name" value="BRICHOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01039">
        <property type="entry name" value="BRICHOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50869">
        <property type="entry name" value="BRICHOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 14" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0967">Endosome</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="BRICHOS" evidence="15">
        <location>
            <begin position="132"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005025165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="262" mass="30024" checksum="DAF168DF9A78F160" modified="2022-01-19" version="1">MVKVSFNSALAQKEAAKKEEENSQVLILPPDAKEQEDVVVPAGQRRAWCWCMCFGLAFMLAGVILGGAYLYKYFAFQQGGVYFCGIKYIEDGLSLPESGAEAQSARYHTIEQNIQILEEEDVEFISVPVPEFADSDPADIVHDFHRRLTAYLDLSLDKCYVIPLNTSVVMPPKNFLELLINIKAGTYLPQSYLIHEQMIVTDRIENVDQLGFFIYRLCRGKETYKLQRKEAMKGIQKREAVNCRKIRHFENRFAMETLICEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UBY9</accession>
    <name>A0A8C2UBY9_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Tumor protein p53 inducible nuclear protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">TP53INP2</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Autophagosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
            <location evidence="10">Nuclear body</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2UBY9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005033970.1">
        <property type="protein sequence ID" value="ENSCJPP00005024943.1"/>
        <property type="gene ID" value="ENSCJPG00005019629.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063829"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903828">
        <property type="term" value="P:negative regulation of protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001649">
        <property type="term" value="P:osteoblast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001894">
        <property type="term" value="P:tissue homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029431">
        <property type="entry name" value="TP53INP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31671">
        <property type="entry name" value="DIABETES AND OBESITY REGULATED, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31671:SF2">
        <property type="entry name" value="TUMOR PROTEIN P53-INDUCIBLE NUCLEAR PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14839">
        <property type="entry name" value="DOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0072">Autophagy</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="175"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005024943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="219" mass="24612" checksum="62B7743C0C8604DB" modified="2022-01-19" version="1">MFQRLTSLFFSDSSAPEGLEEPKPFVSEEEEEDGWLIIELGGERSKVSHSCGAACPGAQRPMPTLPSPCLMDESWFVTPPPCFTAEEPGPDGVGSSPMEDLLIEHPSMSVYVTSTLEAWDESPGHRRALTVPCSHREVPEPRLERHVPHRSASLSVKAAVLEKVSQARRVQRAKQLAEKPWLSQKALQRQDRARQRPPRRARQRAGSFLHQPCQRHCNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UC15</accession>
    <name>A0A8C2UC15_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Coiled-coil domain containing 92B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">CCDC92B</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UC15"/>
    <dbReference type="Ensembl" id="ENSCJPT00005033125.1">
        <property type="protein sequence ID" value="ENSCJPP00005024284.1"/>
        <property type="gene ID" value="ENSCJPG00005019172.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00430000031027"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040370">
        <property type="entry name" value="CCDC74A/CCDC74B/CCDC92"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039496">
        <property type="entry name" value="CCDC92/74_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14882:SF3">
        <property type="entry name" value="COILED-COIL DOMAIN CONTAINING 92B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14882">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING 74A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14916">
        <property type="entry name" value="CCDC92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCDC92/74 N-terminal" evidence="4">
        <location>
            <begin position="7"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="150"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="63"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="172"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="189"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005024284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="274" mass="31294" checksum="7D256DC7496E6CA0" modified="2022-01-19" version="1">METVSLEHQIQSVQRHIAFLKKEQMELLHGLHLEILRLQKHCSELTHDLEMKELEARQQDALDRELEEKCRAMEAQLQEKEKDNLELRKELRHKETLVAALRSSLRSKERHFLEELKRRSHRVTILDTELQKQTEAAAYLSLQLHATAQRLPGPRSSGRPPPEQPPAEGRSQRRGHRVHQRRTPGVGTRHRDPVREEHDAMPDPALFLYTAQPSAPQRPSPLESPAEPRGTGTAPRAQRLPQPRPQEPTARARPAKGEPGKQPGPGPHGARARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UE74</accession>
    <name>A0A8C2UE74_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Tektin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">TEKT3</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Microtubule inner protein component of sperm flagellar doublet microtubules. Interacts with TEKT1, TEKT2, TEKT4 and TEKT5. Interacts with CCDC38.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cytoplasm</location>
            <location evidence="14">Cytoskeleton</location>
            <location evidence="14">Cilium axoneme</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Flagellum axoneme</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasmic vesicle</location>
            <location evidence="11">Secretory vesicle</location>
            <location evidence="11">Acrosome outer membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the tektin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015735220.1">
        <property type="nucleotide sequence ID" value="XM_015879734.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UE74"/>
    <dbReference type="Ensembl" id="ENSCJPT00005035814.1">
        <property type="protein sequence ID" value="ENSCJPP00005026463.1"/>
        <property type="gene ID" value="ENSCJPG00005020568.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107322097"/>
    <dbReference type="KEGG" id="cjo:107322097"/>
    <dbReference type="CTD" id="64518"/>
    <dbReference type="GeneTree" id="ENSGT00950000182894"/>
    <dbReference type="OrthoDB" id="9886517at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160111">
        <property type="term" value="C:axonemal A tubule inner sheath"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002081">
        <property type="term" value="C:outer acrosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036126">
        <property type="term" value="C:sperm flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030317">
        <property type="term" value="P:flagellated sperm motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060378">
        <property type="term" value="P:regulation of brood size"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048256">
        <property type="entry name" value="Tektin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000435">
        <property type="entry name" value="Tektins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19960">
        <property type="entry name" value="TEKTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19960:SF24">
        <property type="entry name" value="TEKTIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03148">
        <property type="entry name" value="Tektin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00511">
        <property type="entry name" value="TEKTIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6 14" id="KW-0969">Cilium</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 14" id="KW-0282">Flagellum</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0832">Ubl conjugation</keyword>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="417"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005026463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="490" mass="56437" checksum="4093167E75C05ACE" modified="2022-01-19" version="1">MELVGSPLSAVHSHVRPAPTNLLPAISTMASSYKNRFPYYPLSQPLSLPWLPNSYYRTATNHPMLAPFSSGSHGLPPSKMLPFVSNRTSLFTRYTPDDWYRSNLTNYRESETSRNNSENLRVDTSRLIHDKYQQTKKTQMESTKNLGERVNDIEFWKSELCHELDEMIGETNALTDMKKRLERALAETEAPLQVAQECLLHREKRMGIDLVHDNVEKQLFKEVDVIRSCQERMQRYLDRARAQLASNRAAQHEVEKDLADKQTARRIDGKCHHLRNTSDGISYFRGVERVDATISVPESWAKFTDDNILRSQSERAASAKLREDIENLLVVSANEMWNQFNAVNVAFTNRIAETTDAKNKIQTHLAKTLQEIFQTEMSIENIRKAIRDKVPPLKVAQTRLDERTRRPNVELCRDSTQLRLVNEVHELDETIQSLQQRLRDAEETLQILARAKAVLEHDLAVKANSLFIDQEKCMGMRKTFPCTARLVGYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UFV2</accession>
    <name>A0A8C2UFV2_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Cell division cycle 14A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">CDC14A</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cell projection</location>
            <location evidence="14">Kinocilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Spindle pole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2UFV2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005037528.1">
        <property type="protein sequence ID" value="ENSCJPP00005027812.1"/>
        <property type="gene ID" value="ENSCJPG00005021515.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155899"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060091">
        <property type="term" value="C:kinocilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007605">
        <property type="term" value="P:sensory perception of sound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd14499">
        <property type="entry name" value="CDC14_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17657">
        <property type="entry name" value="CDC14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000032">
        <property type="entry name" value="dual specificity protein phosphatase CDC14A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000006">
        <property type="entry name" value="Dual specificity protein phosphatase CDC14B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044506">
        <property type="entry name" value="CDC14_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029260">
        <property type="entry name" value="DSPn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050561">
        <property type="entry name" value="PTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23339">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14671">
        <property type="entry name" value="DSPn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22785">
        <property type="entry name" value="Tc-R-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="18">
        <location>
            <begin position="198"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="19">
        <location>
            <begin position="280"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="540"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="552"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005027812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="613" mass="68937" checksum="773199D75767ADCB" modified="2022-01-19" version="1">MSSEPPRASLLRALFKMEPAAAASEVLGGASEFVKDRLYFATLRNKPKSTVNTHYFCTDDELVYENFYADFGPLNLAMLYRYCCKLNKKLKYFSLSRKKIVYYTSFDQRKRANAAFLIGAYAVIYLRKTPEEAYRTLMSGSNPPYIPFRDASFGNCTYNLTILDCLQGINKALQHGFFDFKTFDVDEYEHYERVENGDFNWIVPGKFLAFSGPHPKSKFENGYPLHAPEAYFPYFRKHNVTSIIRLNKKIYEAKRFTDAGFEHYDLFFIDGSTPSDSIVQRFLNICENANGAIAVHCKAGLGRTGTLIACYIMKHYKFTHAEAIAWIRICRPGSIIGPQQHFLEEKQAMLWLEGDLIQSKQKQRVVDGNINRVLCGLNDMSINDSLNKMQDLDQYGEYDLEDKEGVETKDGLTQGDKLHALKSRRRPCSTSGALRLQDMKLHTRSISQPFRLNTSGSTEGSVSPLKATKIMAVNSSSTERISRITSSSGSNLKSVSINSRLASSLGNLYAASDDDESKMTSLSSRTGFSVSQISRHLNGSLQLPHRNNHELNNNFYNRSSNNGNNLSNQTSFHSTVTDEYASSLLYGPYSSSSTVPESINSCKLSITTTLSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UHH4</accession>
    <name>A0A8C2UHH4_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Discoidin domain-containing receptor 2</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="24">CD167 antigen-like family member B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="25">Neurotrophic tyrosine kinase, receptor-related 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">Receptor protein-tyrosine kinase TKT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">Tyrosine-protein kinase TYRO10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="31" type="primary">DDR2</name>
    </gene>
    <organism evidence="31 32">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="31" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="31" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="31" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="20">Binds hydroxyproline-rich sequence motifs in fibrillar, glycosylated collagen, such as the GQOGVMGFO motif, where O stands for hydroxyproline. Interacts with SRC. Interacts (tyrosine phosphorylated) with SHC1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2UHH4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005036998.1">
        <property type="protein sequence ID" value="ENSCJPP00005027357.1"/>
        <property type="gene ID" value="ENSCJPG00005021220.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154842"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005518">
        <property type="term" value="F:collagen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038062">
        <property type="term" value="F:protein tyrosine kinase collagen receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031214">
        <property type="term" value="P:biomineral tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035988">
        <property type="term" value="P:chondrocyte proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030199">
        <property type="term" value="P:collagen fibril organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003416">
        <property type="term" value="P:endochondral bone growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001503">
        <property type="term" value="P:ossification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090091">
        <property type="term" value="P:positive regulation of extracellular matrix disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010763">
        <property type="term" value="P:positive regulation of fibroblast migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048146">
        <property type="term" value="P:positive regulation of fibroblast proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010976">
        <property type="term" value="P:positive regulation of neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045669">
        <property type="term" value="P:positive regulation of osteoblast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051897">
        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030500">
        <property type="term" value="P:regulation of bone mineralization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034103">
        <property type="term" value="P:regulation of tissue remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000007">
        <property type="entry name" value="Discoidin domain receptor tyrosine kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1190:FF:000001">
        <property type="entry name" value="Discoidin domain receptor tyrosine kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000053">
        <property type="entry name" value="Epithelial discoidin domain-containing receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000082">
        <property type="entry name" value="Epithelial discoidin domain-containing receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048525">
        <property type="entry name" value="DDR1-2_DS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002011">
        <property type="entry name" value="Tyr_kinase_rcpt_2_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF295">
        <property type="entry name" value="DISCOIDIN DOMAIN-CONTAINING RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21114">
        <property type="entry name" value="DDR1-2_DS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01285">
        <property type="entry name" value="FA58C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00239">
        <property type="entry name" value="RECEPTOR_TYR_KIN_II"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 27" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0892">Osteogenesis</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-0675">Receptor</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 28" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 27" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 27" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="14" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="signal peptide" evidence="28">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034458950" description="Discoidin domain-containing receptor 2" evidence="28">
        <location>
            <begin position="27"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="30">
        <location>
            <begin position="33"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="29">
        <location>
            <begin position="560"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="449"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="493"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="26">
        <location>
            <begin position="449"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022692"/>
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            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022777"/>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022855"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00051243"/>
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    </evidence>
    <evidence type="ECO:0000256" key="19">
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            <dbReference type="ARBA" id="ARBA00061639"/>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00076913"/>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="PROSITE" id="PS50011"/>
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    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="856" mass="95808" checksum="8984ED835D7EFE25" modified="2022-01-19" version="1">MPALPRAALLLLLLLLLLCILLAARAQVNPAVCRYPLGMSGGHIPDEDISASSQWSESTAAKYGRLDSEEGDGAWCPEIPVEPDDLKEFLQIDLRALHFITLVGTQGRHAGGHGNEFAPMYKINYSRDGTRWISWRNRHGKQVRRLQGTAFPHASAPCCAHWVLCMAAHGLVGACLSVSHCPFPTDGLVSYSAPAGQQLVLPSGTIIYLNDSVYDGAFGYSMTEGLGQLTDGVSGLDDFTQTHEYHVWPGYDYVGWRNESTAGGYVEITFEFDRIRNFTTMKVHCNNMFSKGVKIFKEVQCYFRSDAGEWEPNAISSVLVLDDVNPSARFVTVPLLHRMASAIKCQYYFADTWMMFSEITFQSDAAMYNNSAVPPEMPMAPTTSDPTLKMDDSNTRILIGCLVAIIFILVAIIVIILWRQFWQKMLEKASRRMLDDEMTVSLSLPSESSMFNHNRSSSSSEHESNSTYDRIFPLGPDYQEPSRLIRKLPEFTAGEEDTGCSGPVKPSPASGPEGVPHYAEAEIVNLQGVTGGNTYSVPALTMDLLSGKDVAVEEFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFADKEFTLEGLDASPNCPVLVAVKMLRADANKNARNDFLKEIKIMSRLKDPNIIRLLGVCVTDDPLCMITEYMENGDLNQFLSRHEAQSPPDAQVPTISYSNLRFMATQIASGMKYLASLNFVHRDLATRNCLVGNNYTIKIADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTLCREQPYSQLSDEQVIENTGEFFRDQGRQTYLPKPALCPDSIYKLMLSCWRRDTKDRPSFQDLHRQLQEAAAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y4Z1</accession>
    <name>A0A8C2Y4Z1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y4Z1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005000623.1">
        <property type="protein sequence ID" value="ENSCJPP00005000325.1"/>
        <property type="gene ID" value="ENSCJPG00005000409.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000013075"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16475">
        <property type="entry name" value="RING-H2_RNF121-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040176">
        <property type="entry name" value="RNF121/RNF175"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13407:SF2">
        <property type="entry name" value="RING FINGER PROTEIN 175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13407">
        <property type="entry name" value="RNF121 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="62"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005000325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="149" mass="17072" checksum="66EE0BA5581C23A1" modified="2022-01-19" version="1">KGCEGQKEHKTSPKRKEYLSACSKITMTTKIAATTYWMQEKQRWPLYNIIGITTRNLSNDICSVCGQKIFVDTNEEGITENTHQLSCNHMFHELCMCGWCTVGKKETCPHCGKKLDLKMALSGNAGYMVVGIVLYINYFLYLEQKSDYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y5U0</accession>
    <name>A0A8C2Y5U0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">ATP-dependent RNA helicase TDRD9</fullName>
            <ecNumber evidence="4">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Tudor domain-containing protein 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">TDRD9</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="4"/>
    <dbReference type="RefSeq" id="XP_015721014.1">
        <property type="nucleotide sequence ID" value="XM_015865528.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005004947.1">
        <property type="protein sequence ID" value="ENSCJPP00005002653.1"/>
        <property type="gene ID" value="ENSCJPG00005002971.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107315311"/>
    <dbReference type="KEGG" id="cjo:107315311"/>
    <dbReference type="CTD" id="122402"/>
    <dbReference type="GeneTree" id="ENSGT00940000157035"/>
    <dbReference type="OrthoDB" id="66977at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071547">
        <property type="term" value="C:piP-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009566">
        <property type="term" value="P:fertilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007141">
        <property type="term" value="P:male meiosis I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034587">
        <property type="term" value="P:piRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141196">
        <property type="term" value="P:transposable element silencing by piRNA-mediated DNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141006">
        <property type="term" value="P:transposable element silencing by piRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20431">
        <property type="entry name" value="Tudor_TDRD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000073">
        <property type="entry name" value="ATP-dependent RNA helicase TDRD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001113">
        <property type="entry name" value="ATP-dependent RNA helicase TDRD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000946">
        <property type="entry name" value="putative ATP-dependent RNA helicase TDRD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000081">
        <property type="entry name" value="Tudor domain containing 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.90:FF:000016">
        <property type="entry name" value="Tudor domain containing 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047384">
        <property type="entry name" value="Tudor_TDRD9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF113">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE TDRD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00567">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-0221">Differentiation</keyword>
    <keyword evidence="10" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0469">Meiosis</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="12" id="KW-0744">Spermatogenesis</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="21">
        <location>
            <begin position="127"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="22">
        <location>
            <begin position="343"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="20">
        <location>
            <begin position="925"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00074173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00081664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005002653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1353" mass="153462" checksum="7C2C68B9721D3D66" modified="2022-01-19" version="1">MAAFQSLFVHHRDRPQLGVTKRLSREVVERTSGAGSTNAATRQTGSCGLGGNVFKRLPTSERSETECAEEYRQAEAQKRDASGSDQFVCEQDTSVPNCEPHVGNSIPITTNHKYAGMPVARHREELLSLIESNSVVIIQGATGSGKSTQLPQYVLDHYTEKSICCNIGVTQPRKIGASSIARWICKERSWTLGRFVGYQVGLENVSSTETRLLYMTTGVLLQKVVTAKSLTEFTHIFIDEVHERTEDMDFLLLVVRKLLRTNSQSVKIILMSATINCKEIADYFAMPTQNGLNPACIFKVEGKPYAVEEYYLDDLKHIVHFRLPSQRIDKPMIGSELYEVAVSLIQSFDELEMQSNGGSFTPDRGSVLVFLPGFCEISHMHSRLTRMFNKKWQVYPLHSRVSLEEQNNVFLNPVPGYRKIILSTNIAESSVTVPDVKYVIDFCLTRIVFCDEETNYQSLRLCWASKTNCYQRRGRAGRVSNGYCYRLVYKEFWTDYIPEKSLPEMLTRPLGATVLKIKKLDMGEPKALLATALSPPNISDIERTILHLKELGALTACVKGEENPCDGELTFLGNILVHLPVDLHLGKLIVLGHVFGCLEECLIIAAALSLQNFFVEPFKQTIDGYRSKLFFCGNSKSDCIAIVNAFKAWQICRQNGDLRHPKDELEWGRSNYIHIKKVREVAELVQLLKERVKPFNMHVNTELSAMDQDYVCKQHFILQVVMAGAFYPNYFSFQRCNEQGAVRDLGGKDPKTTVMLRNVPPYGYLYHNQLQSQFRQCGQVKSVMFDGTRALVEFSHNPVEGLNVLPAVYMSIKMSQLKIPLELDVHYPGDIKKALQHVGHATVTDMDSLRVNVDYQKQTVEPVEVSFGISHLLKKIPNRLLSISVTEIVEVGHFWGYRIDEKNRSVLQTLTAELSYQNLTELSVSPHPELVCLAPFTRLNNTGYYRARILFVTGDFAEVFFVDYGDRSKVPLSKLKEIPSSLRELPFQALEFKICKMRPSAKSLVCGERWSFSASRRFASLVNGYTLLVEVYSLVHSVLHVDAFHYTSHRDLVNIRDVLIEEHYAELAEESYESQQSHDLLKGFFNGKVEKENVSVSSREEKKDLIEILLKWFSDKKSDAPTHKVTVSGPFSPYEVKCHGVTRVSRFRNAVIRKGSINSVVVQDAPEHSSEQFLVAASLSLSENGATMFLEETSLMPPIPGLLALLSMLFAPAIELRNDKDGKYFTGALCGLGWSQTCRAPLLPENDVELTFDVRFDVDDILQINILREVINKLLYECAVCSQKEKMPQLQENVRQLLLCLICKRRPAVVPKWYENPYAWNQVDPQYIIDQSEKKHKREDGLYQLHQLVRLNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y5V9</accession>
    <name>A0A8C2Y5V9_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Zinc finger protein AEBP2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">AEBP2</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the AEBP2/jing C2H2-type zinc-finger family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015723696.1">
        <property type="nucleotide sequence ID" value="XM_015868210.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y5V9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005005094.1">
        <property type="protein sequence ID" value="ENSCJPP00005002761.1"/>
        <property type="gene ID" value="ENSCJPG00005003055.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107316563"/>
    <dbReference type="KEGG" id="cjo:107316563"/>
    <dbReference type="CTD" id="121536"/>
    <dbReference type="GeneTree" id="ENSGT00510000048519"/>
    <dbReference type="OrthoDB" id="9984614at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035098">
        <property type="term" value="C:ESC/E(Z) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000323">
        <property type="entry name" value="zinc finger protein AEBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000471">
        <property type="entry name" value="Zinc finger protein AEBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052130">
        <property type="entry name" value="AEBP2/jing_C2H2-ZnF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059034">
        <property type="entry name" value="SH3_AEBP2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46541">
        <property type="entry name" value="ZINC FINGER PROTEIN AEBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46541:SF1">
        <property type="entry name" value="ZINC FINGER PROTEIN AEBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26014">
        <property type="entry name" value="SH3_AEBP2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="247"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="314"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="337"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="31"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="102"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="164"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="338"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="363"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00073372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005002761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="497" mass="51996" checksum="DA57EDE870BE8F2D" modified="2022-01-19" version="1">MAAARSDMAEPEGLLPGEAAAAAAEEEEEAAAVAAVVAGVGSSSSPPSSAAETESLLLLNGEAESMSEPSPESASQAGDGEDEDEEEEEEEEEEGGEEEESSLVGSSSTSSGCCSDETRSLSPGGSSEADAKEEPKGPRGGQEGGLGRGGGGGGSSSSSVSSGGDEGYGTGGGGGSSGSSSCSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPVMMNGQGVPASSAKSIAYNCCWDHCHACFSSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVASQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWTPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRNSSKGGTYSGILKDHFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y6W1</accession>
    <name>A0A8C2Y6W1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tubby-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">TUB</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the TUB family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015719583.1">
        <property type="nucleotide sequence ID" value="XM_015864097.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y6W1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005007994.1">
        <property type="protein sequence ID" value="ENSCJPP00005004864.1"/>
        <property type="gene ID" value="ENSCJPG00005004714.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107314641"/>
    <dbReference type="CTD" id="7275"/>
    <dbReference type="GeneTree" id="ENSGT00940000158372"/>
    <dbReference type="OrthoDB" id="8775810at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120160">
        <property type="term" value="F:intraciliary transport particle A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042073">
        <property type="term" value="P:intraciliary transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006910">
        <property type="term" value="P:phagocytosis, recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045494">
        <property type="term" value="P:photoreceptor cell maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050766">
        <property type="term" value="P:positive regulation of phagocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903546">
        <property type="term" value="P:protein localization to photoreceptor outer segment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097500">
        <property type="term" value="P:receptor localization to non-motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008277">
        <property type="term" value="P:regulation of G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060041">
        <property type="term" value="P:retina development in camera-type eye"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007605">
        <property type="term" value="P:sensory perception of sound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.90.10:FF:000001">
        <property type="entry name" value="Tubby-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.90.10">
        <property type="entry name" value="Tubby Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025659">
        <property type="entry name" value="Tubby-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000007">
        <property type="entry name" value="Tubby_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018066">
        <property type="entry name" value="Tubby_C_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005398">
        <property type="entry name" value="Tubby_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16517:SF20">
        <property type="entry name" value="TUBBY PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16517">
        <property type="entry name" value="TUBBY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01167">
        <property type="entry name" value="Tub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16322">
        <property type="entry name" value="Tub_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01573">
        <property type="entry name" value="SUPERTUBBY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01574">
        <property type="entry name" value="TUBBYPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54518">
        <property type="entry name" value="Tubby C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01200">
        <property type="entry name" value="TUB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01201">
        <property type="entry name" value="TUB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Tubby N-terminal" evidence="9">
        <location>
            <begin position="35"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Tubby N-terminal" evidence="9">
        <location>
            <begin position="198"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Tubby C-terminal" evidence="8">
        <location>
            <begin position="282"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="40"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="107"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="150"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="197"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="223"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="239"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005004864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="530" mass="59036" checksum="0BC3E19442F1224D" modified="2022-01-19" version="1">MDGVGSSRTMSYSRWSYNSVLDDEGSNLRQQKLDRQRALLEQKQKKKRQEPLMVQSNVDSRTRARRTKHSEEQAPLVESYLNSNSSTIYHVQEAEQEDVKVVVDAQAPKSTKKAKAASASCQTGSARKEKKGKHKGIDGPAAFQDDVQKAGSQVQILTVGQSSHDEDDGEKMATGQQQQSKQDLKTAMQKKDPHANTSWSSSTSQSSLVALDHAPGISSSMNFDEEEDEEDADSSSSSQLNSNTRPGSATSKKSSKEVASAPSPSTNEPLIDVDDLEEFAVRPAPQGATVKCRITRDKKGMDRGMYPTYYLHLEREHGKKVFLLAGRKRKKSKTSNYLISIDPTDLSRGGESFIGKLRSNLMGTKFTVYDNGVNPMKTTSSLEASVLRQELAAICYETNVLGFKGPRKMSVIIPGMNMDHERVSIRPRNEHETLLARWQNKNTESVIELHNKTPVWNDDTQSYVLNFHGRVTQASVKNFQIIHDNDPDYIVMQFGRVAEDVFTMDYNYPLCALQAFAIALSSFDSKLACE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y6Z8</accession>
    <name>A0A8C2Y6Z8_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein BTG1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">B-cell translocation gene 1 protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BTG1</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Anti-proliferative protein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BTG family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015713542.1">
        <property type="nucleotide sequence ID" value="XM_015858056.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y6Z8"/>
    <dbReference type="SMR" id="A0A8C2Y6Z8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005008317.1">
        <property type="protein sequence ID" value="ENSCJPP00005005072.1"/>
        <property type="gene ID" value="ENSCJPG00005004908.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107311516"/>
    <dbReference type="KEGG" id="cjo:107311516"/>
    <dbReference type="CTD" id="694"/>
    <dbReference type="GeneTree" id="ENSGT00950000182952"/>
    <dbReference type="OrthoDB" id="19928at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008283">
        <property type="term" value="P:cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045766">
        <property type="term" value="P:positive regulation of angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045603">
        <property type="term" value="P:positive regulation of endothelial cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000271">
        <property type="term" value="P:positive regulation of fibroblast apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045663">
        <property type="term" value="P:positive regulation of myoblast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.90:FF:000003">
        <property type="entry name" value="BTG1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.90">
        <property type="entry name" value="Anti-proliferative protein, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002087">
        <property type="entry name" value="Anti_prolifrtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033332">
        <property type="entry name" value="BTG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036054">
        <property type="entry name" value="BTG-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22978">
        <property type="entry name" value="B-CELL TRANSLOCATION GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22978:SF30">
        <property type="entry name" value="PROTEIN BTG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07742">
        <property type="entry name" value="BTG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00310">
        <property type="entry name" value="ANTIPRLFBTG1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00099">
        <property type="entry name" value="btg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160696">
        <property type="entry name" value="BTG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00960">
        <property type="entry name" value="BTG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01203">
        <property type="entry name" value="BTG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anti-proliferative protein" evidence="5">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="Anti-proliferative protein" evidence="6">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS01203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005005072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="170" mass="19188" checksum="BA4BA1BFCBCEA2B4" modified="2022-01-19" version="1">MHPALYTRASMIREIAAAVAFISKFLRTKGLMNERQLQTFSQSLQELLAEHYKHHWFPEKPCKGSGYRCIRINHKMDPLIGQAAQRIGLSSQELFQLLPSELTLWVDPYEVSYRIGEDGSICVLYEAAPAGGSQNNTNMQMVDSRISCKEELLLGRTSPSKSYNMMTVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y7G0</accession>
    <name>A0A8C2Y7G0_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Dishevelled binding antagonist of beta catenin 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">DACT1</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dapper family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015721255.1">
        <property type="nucleotide sequence ID" value="XM_015865769.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y7G0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005009585.1">
        <property type="protein sequence ID" value="ENSCJPP00005006034.1"/>
        <property type="gene ID" value="ENSCJPG00005005685.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107315414"/>
    <dbReference type="KEGG" id="cjo:107315414"/>
    <dbReference type="CTD" id="51339"/>
    <dbReference type="GeneTree" id="ENSGT00950000183181"/>
    <dbReference type="OrthoDB" id="9448112at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030877">
        <property type="term" value="C:beta-catenin destruction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042826">
        <property type="term" value="F:histone deacetylase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051018">
        <property type="term" value="F:protein kinase A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061629">
        <property type="term" value="F:RNA polymerase II-specific DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140416">
        <property type="term" value="F:transcription regulator inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904864">
        <property type="term" value="P:negative regulation of beta-catenin-TCF complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000134">
        <property type="term" value="P:negative regulation of G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046329">
        <property type="term" value="P:negative regulation of JNK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021915">
        <property type="term" value="P:neural tube development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090263">
        <property type="term" value="P:positive regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045732">
        <property type="term" value="P:positive regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031647">
        <property type="term" value="P:regulation of protein stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000095">
        <property type="term" value="P:regulation of Wnt signaling pathway, planar cell polarity pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024843">
        <property type="entry name" value="Dapper"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15919:SF12">
        <property type="entry name" value="DAPPER HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15919">
        <property type="entry name" value="DAPPER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15268">
        <property type="entry name" value="Dapper"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="392"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="466"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="588"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="95"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="392"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="414"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="505"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="517"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="599"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="609"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="821" mass="89288" checksum="D16DF49F7A1434EA" modified="2022-01-19" version="1">MKPSPTAAAAAAGPGLGQTAGGADARWREKGEAEAERQRTRERLEATLAGLGELEYLRQRQELLVKSLLLRRAPGAQGGRGEQQGEGPPPRSLEEKFLEENILLLRRQLNCLRRRDAGLLNQLQELDKQISDLRLDVEKTTDEHLETDSRPSSGFYELSDGASGSLSNSSNSVFSECLSSCHSSTCFCSPLEATLNISDGRPKSADLIGWMDYNKESQREDQAAGSVCRSLSTPHSNSLDVVADVHPKYQCDLVSKNGSDVYRYPSPLHAVAVQSPMFLLPVTENPQREEERLDCDITDVCAGSETDSGKATDAFLPPGSWPASCPSASKRIDGYILSLVQRKTHSVRTNKPRTSLNADPTKGILRHGSMCVRQAAGVVSHSNVVNLKSAKQVSLPSSGATAPDNTAPSPLKQRPREAGGEQVESRKVLLPSTFPPSEVQSKHQPRGAKAVPPEINRHAVAATGDVPKEGSQHFAASPKESPGKPVVLQPETRVSQPPKKVLLKSSSQVAHSSSPPVEERPALDFKSEGSSSQSLDDGLLVNAQYIPAQQQSVKLHKGTRNVKILKSSALKHRPHLANGLENGAQALREKGKPMGKKCRFPDELDTNKKLKKPSSRGKRGGGLQPESGLQGRPTGLHKSVVRSHGHGREVVVAKPKHKRADYRRWKSSAEISYEEALRRARRNRRDGVGVYAQVPLPYVSPYAYVASDSEYSAECESLFHSTVVDTSEDEQSNYTTNCFGDSESSLSEVEFVGESTTTSDSDESGGLIWSQFVQTLPIQTVTAPELHENAAKAFVKIKASHNLKKKILRFRSGSLKLMTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y8R0</accession>
    <name>A0A8C2Y8R0_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">F-box protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">FBXO5</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015713717.1">
        <property type="nucleotide sequence ID" value="XM_015858231.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032299502.1">
        <property type="nucleotide sequence ID" value="XM_032443611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y8R0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005013110.1">
        <property type="protein sequence ID" value="ENSCJPP00005008675.1"/>
        <property type="gene ID" value="ENSCJPG00005007733.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107311593"/>
    <dbReference type="KEGG" id="cjo:107311593"/>
    <dbReference type="CTD" id="26271"/>
    <dbReference type="GeneTree" id="ENSGT00530000063692"/>
    <dbReference type="OrthoDB" id="9984940at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072687">
        <property type="term" value="C:meiotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990948">
        <property type="term" value="F:ubiquitin ligase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046785">
        <property type="term" value="P:microtubule polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000773">
        <property type="term" value="P:negative regulation of cellular senescence"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032876">
        <property type="term" value="P:negative regulation of DNA endoreduplication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045835">
        <property type="term" value="P:negative regulation of meiotic nuclear division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045841">
        <property type="term" value="P:negative regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001556">
        <property type="term" value="P:oocyte maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070169">
        <property type="term" value="P:positive regulation of biomineral tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905322">
        <property type="term" value="P:positive regulation of mesenchymal stem cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045669">
        <property type="term" value="P:positive regulation of osteoblast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007057">
        <property type="term" value="P:spindle assembly involved in female meiosis I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016050">
        <property type="term" value="P:vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd20364">
        <property type="entry name" value="BRcat_RBR_FBXO5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.20:FF:000006">
        <property type="entry name" value="F-box only protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047147">
        <property type="entry name" value="FBX5_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044064">
        <property type="entry name" value="ZF_ZBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15493:SF8">
        <property type="entry name" value="F-BOX ONLY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15493">
        <property type="entry name" value="F-BOX ONLY PROTEIN 5 AND 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51872">
        <property type="entry name" value="ZF_ZBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZBR-type" evidence="15">
        <location>
            <begin position="330"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="299"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005008675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="403" mass="45567" checksum="2360D2C7B093AE7A" modified="2022-01-19" version="1">MKSNLNRSFKMKCDFDRTALHGGFTPVKSAAEKTKLEEPFEEKLCRSCAEEHQKILSEPYHAAPRILDPEDEGKPVHNKENKHVTQRFDEGVYEMEALENSKLIEDSGYSSMLSSQYSDATEQEDSLPLAGNFCSTPEHCLEKNEIQVHLSKKTLLPVSHYEEVMCSTLKKSGKRNLKSWTAFDRIAFRESFELRNLIGKKMGLDRVDILAELFQKNLKHILASILRHLGEMDLINFAKVSATWKKVLQEDKRGFEMYSKALKNLSNGTKTSEHAATREYVLYRAALAPVQKATPPKSLSKKGSRSKASKNHSRLVEFSEAAKTLKNTESFKVCSRCGSPAKYDSYLQRATCNREGCGFDFCTKCMCSYHSSNDCMSGKPVKSSFKLGALPGTKKSKQNLRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y8R3</accession>
    <name>A0A8C2Y8R3_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Solute carrier family 30 member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">SLC30A1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y8R3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005012695.1">
        <property type="protein sequence ID" value="ENSCJPP00005008352.1"/>
        <property type="gene ID" value="ENSCJPG00005007490.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156484"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019855">
        <property type="term" value="F:calcium channel inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010312">
        <property type="term" value="P:detoxification of zinc ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090281">
        <property type="term" value="P:negative regulation of calcium ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071584">
        <property type="term" value="P:negative regulation of zinc ion transmembrane import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062111">
        <property type="term" value="P:zinc ion import into organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820">
        <property type="entry name" value="FI23527P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820:SF1">
        <property type="entry name" value="PROTON-COUPLED ZINC ANTIPORTER SLC30A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="331"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="10">
        <location>
            <begin position="105"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="11">
        <location>
            <begin position="438"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="34"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="236"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="570"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="275"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="586"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005008352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="597" mass="64317" checksum="C7B675B247DDE22D" modified="2022-01-19" version="1">MGRGLGGVSVPARVPCGKSEGARVQSLLARRQRWERRPSGRVGRRRDGAALSVGAPPRAARRLSSHPGRVGPAAAVARPGATCGGMAAEGPGGPRWWQNRRARLLCMLALTFLFFVVEVAVSRVTASLAMLSDSFHMLSDVMALVVALVAVRFAQRTRATKKNTFGWVRAEVMGALVNAVFLTALCFTILLEAIERFTEPHEIQQPLVVIAVGVAGLVINLLGLCLFNHHGVGGHGHSHGHGHAHGGGSRLPRGSGKAEQSPADGEAALHRDETSTLVENCSGSNGLSQDKLGDMKDDTTDLQVNGNASHYPLDVEEVEEDSSAQLNMRGVFLHVFGDALGSVIVVVNALLFYGLWNPCPKDGPCFNPCVNSHCVENATLSQPLGSANKSEQESITVAGPCWLLYLDPVLCLIMVCILLYTTYPLLRESALILLQTVPKQIDVHSLNSKLRTLEGVEAVHELHIWQLAGSRIIGTAHIKCPDPSTYMMVAKRIKEIFHDEGIHATTIQPEFASVGSESGRGKCEFPCRTQCALKQCCGTIEDNAGKKTEKSSSLSISCSEVVIEFPHNKTRRTKSESVPAVKLEANTDQNEQFESSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y8W3</accession>
    <name>A0A8C2Y8W3_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Orthopedia homeobox</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">OTP</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015704009.1">
        <property type="nucleotide sequence ID" value="XM_015848523.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y8W3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005013512.1">
        <property type="protein sequence ID" value="ENSCJPP00005009000.1"/>
        <property type="gene ID" value="ENSCJPG00005007969.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107305878"/>
    <dbReference type="KEGG" id="cjo:107305878"/>
    <dbReference type="CTD" id="23440"/>
    <dbReference type="GeneTree" id="ENSGT00940000159952"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome Z"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001650">
        <property type="term" value="C:fibrillar center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071542">
        <property type="term" value="P:dopaminergic neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021879">
        <property type="term" value="P:forebrain neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021979">
        <property type="term" value="P:hypothalamus cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007405">
        <property type="term" value="P:neuroblast proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061101">
        <property type="term" value="P:neuroendocrine cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021985">
        <property type="term" value="P:neurohypophysis development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002052">
        <property type="term" value="P:positive regulation of neuroblast proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000679">
        <property type="entry name" value="Homeobox protein aristaless"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003654">
        <property type="entry name" value="OAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051895">
        <property type="entry name" value="OTP_Homeobox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46770">
        <property type="entry name" value="HOMEOBOX PROTEIN ORTHOPEDIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46770:SF1">
        <property type="entry name" value="HOMEOBOX PROTEIN ORTHOPEDIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03826">
        <property type="entry name" value="OAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50803">
        <property type="entry name" value="OAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="102"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="OAR" evidence="10">
        <location>
            <begin position="306"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="104"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="32"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="283"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005009000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="325" mass="34327" checksum="3F8492B4E6190F8D" modified="2022-01-19" version="1">MLSHADLLDARLGMKDAAELLGHREAVKCRLGVGGSDPGGHPGDMAPNSDTVEGTTLLPGEDITTVGSNPSSLAVSAKDADKQQGQQGGQNPSQAGQQQGQQKQKRHRTRFTRAQLDVLEALFAKTRYPDIFMREEVALKIDLTESRVQVWFQNRRAKWKKRKKTTNVFRAPGTLLPTPGLPQFPSAAAAAAAAMGDSLCSFHANDTRWAAAAMPGVSQLPLPPALGRQQAMAQSLSQCSLAAGPPPNSMGLSNSLAGSNGAGLQSHLYQPAFPGMVPASLPGPSNVTGSPQLCSSPDSSDVWRGTSIASLRRKALEHTVSMSFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YAG7</accession>
    <name>A0A8C2YAG7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">argininosuccinate lyase</fullName>
            <ecNumber evidence="3">4.3.2.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.1" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2YAG7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005017820.1">
        <property type="protein sequence ID" value="ENSCJPP00005012288.1"/>
        <property type="gene ID" value="ENSCJPG00005010444.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183122"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004056">
        <property type="term" value="F:argininosuccinate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005212">
        <property type="term" value="F:structural constituent of eye lens"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:L-arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01359">
        <property type="entry name" value="Argininosuccinate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.200.10:FF:000015">
        <property type="entry name" value="argininosuccinate lyase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.10:FF:000014">
        <property type="entry name" value="Os03g0824900 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00006">
        <property type="entry name" value="Arg_succ_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029419">
        <property type="entry name" value="Arg_succ_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009049">
        <property type="entry name" value="Argininosuccinate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00838">
        <property type="entry name" value="argH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814">
        <property type="entry name" value="ARGININOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814:SF1">
        <property type="entry name" value="ARGININOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14698">
        <property type="entry name" value="ASL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00145">
        <property type="entry name" value="ARGSUCLYASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0273">Eye lens protein</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarate lyase N-terminal" evidence="8">
        <location>
            <begin position="13"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Argininosuccinate lyase C-terminal" evidence="9">
        <location>
            <begin position="360"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005012288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="433" mass="47618" checksum="4E6361E09BD3C202" modified="2022-01-19" version="1">MASEVRGDKLWGGRFSGSTDPIMEMLNSSIAYDQRLSQVDIQGSMAYAKALEKAGILTKTELEKILSGLEKISEEWSKGVFVVKQSDEDIHTANERRLKELIGDIAGKLHTGRSRNDQVVTDLKLLLKSSISVISTSPAAKFDVIMPGYTHLQKALPIRWSQFLLSHAVALTRDSERLGDVKKRMDVLPLGSGALAGNPLEIDRELLCSELDFASISLNSMDAISERDFVVELLSVATLLMIHLSKLAEDLIIFSTTEFALAAACCLRRKNPDSLELIRSKAGRVFGRLAAILMVLKGLPSTYNKDLQEDKEAVFDVVDTLTAVLQVATGVISTLQINKENMEKALTPELLDHHLSFSLQMPFRQAHAASGKAVHLAETKGIAINKLTLEDLKSISPLFASMSPVFNTVSSVEQYTAMVVLPRELLKKQKEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YB17</accession>
    <name>A0A8C2YB17_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Polyadenylate-binding protein-interacting protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">PAIP2</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. Its inhibitory activity on translation is mediated via its action on PABPC1. Displaces the interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for binding to PABPC1. Its association with PABPC1 results in disruption of the cytoplasmic poly(A) RNP structure organization.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PAIP2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015731513.1">
        <property type="nucleotide sequence ID" value="XM_015876027.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015731515.1">
        <property type="nucleotide sequence ID" value="XM_015876029.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YB17"/>
    <dbReference type="Ensembl" id="ENSCJPT00005019392.1">
        <property type="protein sequence ID" value="ENSCJPP00005013507.1"/>
        <property type="gene ID" value="ENSCJPG00005011388.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107320312"/>
    <dbReference type="KEGG" id="cjo:107320312"/>
    <dbReference type="CTD" id="51247"/>
    <dbReference type="GeneTree" id="ENSGT00390000017284"/>
    <dbReference type="OrthoDB" id="5985142at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000900">
        <property type="term" value="F:mRNA regulatory element binding translation repressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007613">
        <property type="term" value="P:memory"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045947">
        <property type="term" value="P:negative regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900271">
        <property type="term" value="P:regulation of long-term synaptic potentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040396">
        <property type="entry name" value="PAIP2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009818">
        <property type="entry name" value="PAM2_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13154">
        <property type="entry name" value="POLYADENYLATE-BINDING PROTEIN-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13154:SF2">
        <property type="entry name" value="POLYADENYLATE-BINDING PROTEIN-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07145">
        <property type="entry name" value="PAM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="4" id="KW-0832">Ubl conjugation</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005013507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="127" mass="15043" checksum="F3502EB5B070986B" modified="2022-01-19" version="1">MKDPSRSSTSPSIISEDVIINGHSHEDDNPFAEYMWMENEEEFNRQIEEELWEEEFIERCFQEMLEEEEEHEWFIPARDLPQTMDQIQDQFNDLVISDSSSLEDLVVKSNLNPNAKEFVPGVKYLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YBC2</accession>
    <name>A0A8C2YBC2_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transmembrane p24 trafficking protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">TMED4</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Membrane</location>
            <topology evidence="8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015738524.1">
        <property type="nucleotide sequence ID" value="XM_015883038.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YBC2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005020211.1">
        <property type="protein sequence ID" value="ENSCJPP00005014143.1"/>
        <property type="gene ID" value="ENSCJPG00005011839.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107323699"/>
    <dbReference type="KEGG" id="cjo:107323699"/>
    <dbReference type="CTD" id="222068"/>
    <dbReference type="GeneTree" id="ENSGT00940000159012"/>
    <dbReference type="OrthoDB" id="9097319at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034214461" evidence="9">
        <location>
            <begin position="24"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="10">
        <location>
            <begin position="33"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005014143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="198" mass="22125" checksum="13725D070A3596BA" modified="2022-01-19" version="1">MAGGSALSAALSVLVLMAAGARGLYFHIGETEKRCFIEEIPDETMVIGNYRTQLWDKQSESFLPSTPGLGMHVEVKDPDGKVVLSRQYGSEGRFTFTSHTPGEHQICLHSNSTRMALFAGGKLRVHLDIQVGEHTNNYPEIAAKDKLTELQLRARQLLDQVEQIQKEQNYQRVGTTYTVCHIDPPRPHNPFLTHITTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YBI8</accession>
    <name>A0A8C2YBI8_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C-X-C chemokine receptor type 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">CXCR5</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015739545.1">
        <property type="nucleotide sequence ID" value="XM_015884059.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YBI8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005020338.1">
        <property type="protein sequence ID" value="ENSCJPP00005014252.1"/>
        <property type="gene ID" value="ENSCJPG00005011914.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107324228"/>
    <dbReference type="KEGG" id="cjo:107324228"/>
    <dbReference type="CTD" id="643"/>
    <dbReference type="GeneTree" id="ENSGT01050000244848"/>
    <dbReference type="OrthoDB" id="9818824at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019957">
        <property type="term" value="F:C-C chemokine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016493">
        <property type="term" value="F:C-C chemokine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016494">
        <property type="term" value="F:C-X-C chemokine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042113">
        <property type="term" value="P:B cell activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030595">
        <property type="term" value="P:leukocyte chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032467">
        <property type="term" value="P:positive regulation of cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007204">
        <property type="term" value="P:positive regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15181">
        <property type="entry name" value="7tmA_CXCR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000143">
        <property type="entry name" value="C-X-C chemokine receptor type 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050119">
        <property type="entry name" value="CCR1-9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001053">
        <property type="entry name" value="Chemokine_CXCR5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000355">
        <property type="entry name" value="Chemokine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10489:SF618">
        <property type="entry name" value="C-X-C CHEMOKINE RECEPTOR TYPE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10489">
        <property type="entry name" value="CELL ADHESION MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00657">
        <property type="entry name" value="CCCHEMOKINER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00564">
        <property type="entry name" value="CXCCHMKINER5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0075">B-cell activation</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 13" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 13" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="220"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="257"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="301"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="15">
        <location>
            <begin position="70"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00069929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005014252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="371" mass="42165" checksum="1334499121B3C188" modified="2022-01-19" version="1">MGPVSYSSETYDLSQVELSGYYEAENSTPSLEGYFCFNPASSVVGNQRDPFRKVFIPLAYLLMFLLGTVGNALVLVILERFKRSRTTTENFLFHLTLANLALLLTFPFSVVESLAGWVFGTFLCKILSAVHKINFYCSSMLLGCIAVDRYLAIVYAIHTYRKRRARSIHLTCTAIWLSSLLLTLPDLIFMEVWTDESNRSICYFPEAGIHGNNVWLATRFLYHSVGFFMPLLVMCYCYTAIVRALCQSQRLQRQKAVRVAILVTGVFLLCWSPYHIVIFLNTLTKLEAFTKNCLLEDQLDTAIMVTEAIGFTHCCLNPIIYAFIGVKFRNDFFRILHELGCINQETLQEILEVTRKGCGIESDNTTSISTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YC33</accession>
    <name>A0A8C2YC33_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Twist family bHLH transcription factor 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">TWIST2</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015723315.1">
        <property type="nucleotide sequence ID" value="XM_015867829.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015723316.1">
        <property type="nucleotide sequence ID" value="XM_015867830.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YC33"/>
    <dbReference type="SMR" id="A0A8C2YC33"/>
    <dbReference type="Ensembl" id="ENSCJPT00005021881.1">
        <property type="protein sequence ID" value="ENSCJPP00005015428.1"/>
        <property type="gene ID" value="ENSCJPG00005012791.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107316410"/>
    <dbReference type="KEGG" id="cjo:107316410"/>
    <dbReference type="CTD" id="117581"/>
    <dbReference type="GeneTree" id="ENSGT00940000161996"/>
    <dbReference type="OrthoDB" id="8583783at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045668">
        <property type="term" value="P:negative regulation of osteoblast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000030">
        <property type="entry name" value="Twist transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050283">
        <property type="entry name" value="E-box_TF_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349:SF70">
        <property type="entry name" value="TWIST-RELATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="2" id="KW-0221">Differentiation</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="8">
        <location>
            <begin position="66"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="160" mass="18202" checksum="FE5BF41CCD16B337" modified="2022-01-19" version="1">MEESSSSPVSPVDSLGTSEEELERQPKRFGRKRRYSKKSSEDGSPNPGKRGKKSSPSSQSYEELQSQRILANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFLYQVLQSDEMDSKMTSCSYVAHERLSYAFSVWRMEGAWSMSASH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YC69</accession>
    <name>A0A8C2YC69_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cilia and flagella associated protein 65</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">CFAP65</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
            <location evidence="1">Flagellum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015724707.1">
        <property type="nucleotide sequence ID" value="XM_015869221.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005022436.1">
        <property type="protein sequence ID" value="ENSCJPP00005015883.1"/>
        <property type="gene ID" value="ENSCJPG00005013114.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107317029"/>
    <dbReference type="KEGG" id="cjo:107317029"/>
    <dbReference type="CTD" id="255101"/>
    <dbReference type="GeneTree" id="ENSGT00430000031142"/>
    <dbReference type="OrthoDB" id="415597at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001669">
        <property type="term" value="C:acrosomal vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097225">
        <property type="term" value="C:sperm midpiece"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007288">
        <property type="term" value="P:sperm axoneme assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031549">
        <property type="entry name" value="ASH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052614">
        <property type="entry name" value="CFAP65"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053879">
        <property type="entry name" value="HYDIN_VesB_CFA65-like_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056344">
        <property type="entry name" value="Ig_CFAP65-like_9th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056305">
        <property type="entry name" value="Ig_CFAP65_10th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058536">
        <property type="entry name" value="Ig_CFAP65_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057470">
        <property type="entry name" value="Ig_CFAP65_7th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057467">
        <property type="entry name" value="Ig_CFAP65_8th"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46127">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46127:SF1">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15780">
        <property type="entry name" value="ASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22544">
        <property type="entry name" value="HYDIN_VesB_CFA65-like_Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24291">
        <property type="entry name" value="Ig_CFAP65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24507">
        <property type="entry name" value="Ig_CFAP65_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25249">
        <property type="entry name" value="Ig_CFAP65_7th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25248">
        <property type="entry name" value="Ig_CFAP65_8th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24816">
        <property type="entry name" value="Ig_CFAP65__9th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0282">Flagellum</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HYDIN/VesB/CFA65-like Ig-like" evidence="9">
        <location>
            <begin position="154"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Abnormal spindle-like microcephaly-associated protein ASH" evidence="8">
        <location>
            <begin position="275"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="CFAP65 fourth Ig-like" evidence="11">
        <location>
            <begin position="382"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="CFAP65 seventh Ig-like" evidence="14">
        <location>
            <begin position="791"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="domain" description="CFAP65 eight Ig-like" evidence="13">
        <location>
            <begin position="899"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="domain" description="CFAP65-like ninth Ig-like" evidence="12">
        <location>
            <begin position="1025"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="domain" description="CFAP65 tenth Ig-like" evidence="10">
        <location>
            <begin position="1209"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1474"/>
            <end position="1498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1474"/>
            <end position="1483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF15780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF24291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF24507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF24816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF25248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF25249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1780" mass="198554" checksum="0772A9037F8DFFDB" modified="2022-01-19" version="1">MTTGVMLRGAEPGPGGEMLAQLQGEPPNPAPLQRRCSSCIRKPPSRKTKKKSTFWGIEVAETLHWRGWELGKEVIKHLVLKNVHGKTQRLSYRCPSTQFFITVFPQPIALSPGMSLTLPIIFRPTEKRDYEDSICFQKAEGEFSVALRAVLPRPCLSFPAAVQLPLCAVHSAAETTFTVRNVGDLITVFAWETASPFCMIPEHGVLKAGAECTIRVLFQPKAAAVYNVTATCWFGVEEKQKRTMRLRAQAKYPHLQVNVPGEQHIGGQPGKLRDVLCFGSVPVGTTVEKRVEILNMSVVDAPCMIERAKDPLFQDHVFSCDLSHAIVPAKGKLALCVRFQPQAVGEHSTDYFTVTPTGCLQRTVLKMVGSCKGPLVSLNQSSVDFDWINLGERSMQILKISNVSDVPAYYQFDIDNRGSVFSLDRPCGVLEGATTLVLKVTFRPAHPISYHRRVVCLVHHQEPLYVDFFGTCHSDTAKPAILRARHLSWYRTNTVRGLTFYPPDILCAMLKDGKLQMDEKRALMLLPEIPLDEPPKEYTEASPMSEYFYDGISSDLALFPPHVSVSPREHDFGCCVPLCKAEPLPLCITNHTKGKITVAWTPSCGSAFQVTPKSCDIPPLKSSAFRVLFQPTQLNSLYAAELEGFAFYKVLRQYSNIEEDATICPPWCLTIRLRAHTFEAKREHFIPRYRLDVPKTFPPVPSDTDTYCSALLSNTGTSMITFSVNQAACPSVLVKPHSGHIMPGGHQIFFLSTRPVNTVSQQHILPLQLNSYPGYTKEIVLRSCAESLLLLLEDNGNLYFKPVCIGTSSTQRYTIKNCTRLPMAFTWKIHHSDSKILSVRPAAGLLQPYEAMAQAWTFTPDNVTKYLLRAAVFVGWESPAPVSPQSIHYNLRIVGEGALSTIRAQQEHLDLGSVLVGNQKDCSVVLLNDGICSLQYILSVEQLITGLCDSEEVFSGPMALELEHSSGTIPARSKASVKVTVRPAQQLHYTWFISYTICTPAVPDLASTKAKQQPLCCIEVTGAYPTLCVADACSAGSASGISRLLLWRLLSLDTLNEYLQRDPTPSELTYSVPTRHSTCLTPPIYTPLLLDFNFGAAPIGSEPALVMLLLVNNGVVPVEWAFLFPSDQKMDMERWAEDVDLSPQELHQMRIKDNQLFSISPKSGKLLPGQEEAVQLSHRHDFIGTDRLPVLLKVSYGHEILLNFRGVTVEREQRYVHFVSSKHLFTPIAIGTSHPPKQSYELYNGGSTTVMFEVQLDNIVMVQEDNNQHPVFTCLTPRGEIAPGTTGHIEWIFSPLEAKTYLVDVPIHILGGDSALITFQGEGYDPKATGVSATSRELLPPSVLLGSTKLTVPGQAASLSHHRICIGNIPDYARASRLVFLNNISEDKAVTFTWRTSNVKDSEVLQIAPEQGVVQSGESTPCFITLQPSKNVSFYSIELVCEVYIQESLLQYERDLQEWEREKERQAVEFTITEKDLRAEKKPRPPTGRSSNSAETESLCEPSAVVRKFKTLPPIKNNPAAHLPAGKRQRRLLSDKEGSRVWVKPEPPRPILLHLAVTARSHSTEDFFSNFTLEFPKYFLPRPGVHQLLFVDGSVDRDRMEMDPKWLSLATASKEELQIVTDVLTGVIRGLLENTQFHDAARRSLKEPIPYFFQFQHEETAKTQHRGQCSTVPSRLFASPDLFTKENGERKEMRQESSPSNDFLGSWQGLSEVFRHEYLREQKMMMKGQPAFGSLVQMVLENTLQNILVEASRGEVVLTARPRVVALPLSPFRRITSPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YC81</accession>
    <name>A0A8C2YC81_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Otoferlin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Fer-1-like protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="primary">OTOF</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="18">Basolateral cell membrane</location>
            <topology evidence="18">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="19">Cytoplasmic vesicle</location>
            <location evidence="19">Secretory vesicle</location>
            <location evidence="19">Synaptic vesicle membrane</location>
            <topology evidence="19">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Presynaptic cell membrane</location>
            <topology evidence="20">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ferlin family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSCJPT00005022233.1">
        <property type="protein sequence ID" value="ENSCJPP00005015728.1"/>
        <property type="gene ID" value="ENSCJPG00005012987.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155086"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
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        <property type="term" value="C:basolateral plasma membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="entry name" value="C2A_Ferlin"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="C2B_Ferlin"/>
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        <property type="entry name" value="otoferlin isoform X1"/>
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        <property type="entry name" value="C2_domain_sf"/>
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    <dbReference type="InterPro" id="IPR055072">
        <property type="entry name" value="Ferlin_DSRM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12546">
        <property type="entry name" value="FER-1-LIKE"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="OTOFERLIN"/>
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        <property type="match status" value="6"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FerB"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16165">
        <property type="entry name" value="Ferlin_C"/>
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    </dbReference>
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        <property type="entry name" value="C2DOMAIN"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="7"/>
    </dbReference>
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        <property type="match status" value="7"/>
    </dbReference>
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    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-0966">Cell projection</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="17" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="15 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="12" id="KW-0770">Synapse</keyword>
    <keyword evidence="5 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 24" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="1977"/>
            <end position="1997"/>
        </location>
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    <feature type="domain" description="C2" evidence="25">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
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        <location>
            <begin position="248"/>
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        <location>
            <begin position="1477"/>
            <end position="1606"/>
        </location>
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        <location>
            <begin position="1727"/>
            <end position="1878"/>
        </location>
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        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
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        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
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        <location>
            <begin position="661"/>
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        </location>
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        <location>
            <begin position="1313"/>
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        </location>
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        <location>
            <begin position="1370"/>
            <end position="1414"/>
        </location>
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        <location>
            <begin position="198"/>
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        </location>
    </feature>
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    </evidence>
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        </source>
    </evidence>
    <sequence length="2010" mass="227979" checksum="E2332753F59800DD" modified="2022-01-19" version="1">MLHGEASVSISKDSTDVGQLPPFTLPQPTCSSSPPAGLSFYTRVMENCEDEARFDETFRWPVASNIDGNEILEIQVFNYSKVFTNRLIGTFRMVLQKVVEEGHVEVTDTLIDDNNSAIQTSISIEIRYQALDGTVGTWNDKEFLETPSVHSEGDGRYSLETDSLLSGHRQGTDGSVSKSNQQAGKGVFSAMKLGKARPTKDDHRKQDEPAVLEAEDLDRKVMRLGGGLDPDTISLASVTAVTTNVSNKRSKPDIKMEPSAGRPMDYQVSITVIEARQLVGLNMDPVVCVEVGEEKKYTSMKESTNCPYYNEYFVFDFHVPPDVMFDKIIKLSVIHSKNLLRSGTLVGSFKMDVGTVYTQPEHQFYHKWAILSDPEDLTAGLKGYLKCDIAVVGKGDNIKTPHKANETEEDDIEGNLLLPDGVPPERQWARFYIKIYRAEGLPRMNTSIMANVKKALIGENKDLVDPYVQVAFAGQKGKTSVQKSSYEPLWNEQIIFTEMFPPLCKRIKIQIRDSDKVNDVAIGTHFIDLRKISNEGDKGYLPTFGPAWVNMYGSTRNYTLMDEHQELNEGLGEGVSFRARLLMSLAVEILDTTNPEINSSTEVQVEQATPVADNCTGKMEEFFLFGAFLEATMIDRKIGDKPINFEVTIGNYGNQIDGMTKPVLRRKKEGGDGDEEESELLHNSSEDEADEDGEMVSVSSSQPMKPLVTDRNYFHLPYLEKKPCIYIKSWWQDQRRRLYNGNIMDKIADKLEEGLNDVQEMIKTEKPHPERRLRGVLEELSSGCLRFVTLADKDQHHSSRTRLDRERLKSCMRELENMGQQATTLRSQVKKNTMKDKLKQVQNFLQKLRFLADEPQHTIPDIFIWMMSNNKRIAYARVPSKDILYSIVDEEMGKDCAKVKTVFLKLPGKRGFGPAGWTVQAKMEIYLWLGLNKQRKDFLSGLPCGFEEKKTTRGQNLPSFPPISLLYTKKQVFQLRAHMYQARSLFAADSSGLSDPFARVFFTSQSQCTEVLNETLCPTWDQLLVFDNVELYGEAHEMRDDPPIIVIEIYDQDTVGKADFMGRTFAKPVVKMSDEQYCPPRFPPQLEYYQIYRGNSTAGDLLAAFELLQIGSGGKSDLPPIDGPTDIDRGPILPVPLGIRPVLSKYRVEILFWGLRDLKRVNLAQVDRPRVDIECAGKGVQSALIQNYKKNPNFSTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHTVSSLRKFIYRPPDKKAQHWNMTAKQLRGYLAVANGAPCSRPTGEIVVNMEPEVPIKKMETMVKLEANSDAVVKVDVVSDEKEKKKKKKKGGGGGGGGEEIEEEEPDESMLDWWSKYFASIETMKEVGVEQRSRGIEIKLDDSPMKGFKGQAKNKEKSKAPKDDKKKKQQSAPELPEKKNKQKIDELKVFNKELEAEFDNFEDWLHTFNLLRGKIGDNDDNATEEERIVGRFKGSMCVYKVPLPDDITKEAGYDPTFGMFQGIPSNDPINVLVRVYIVRATDLHPADINGKADPYIAIKLGKTDIKDKENYISKQLNPVFGKSFDIEATFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRYYSKHRATCGVSQTYSIHGYNIWRDPMKPSQILSKLCKEGKVDGPHFGPGGRVKVANRVYTGPTEIEDENGQKKQTDEHLALTVLRHWEDVPRAGCKLVPEHVETRPLLNPDKPGIEQGRLEMWVDMFPMDMPAPGPAIDISPRKPKKYELRVIVWNTDEVVLEDDDYFTGEKSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRYIFPFDYLMAEEKIVISKKESMFSWDETEYKIPARLTLQVWDADHFSADDFLGAIELDLNRFPRGAKTSKQCSLEMVTNEAELPMVSIFKQKRVKGWWPFVARDENDELEVTGKVEAELHLLTAEEAEKSPAGLARNEPDPLEKPNRPDTSFIWFLNPLKSIKYLICTRYKWLIIKIVLALLLLIMVALFLYSMPGYMVKKLLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YCL2</accession>
    <name>A0A8C2YCL2_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YCL2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005023467.1">
        <property type="protein sequence ID" value="ENSCJPP00005016749.1"/>
        <property type="gene ID" value="ENSCJPG00005013740.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005016749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="114" mass="12805" checksum="67BE69012500E6BC" modified="2022-01-19" version="1">FFNNPRGLHLMAKCKFPISQLAPVAAHPVARWLWWGCLRCSGTSDRSCSLEFSGWLANAKSKDSQEASTIYCSHSHRNSFIPNVLQMSFSLFPSTTVGTLFLFIKISTFEASQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YDF9</accession>
    <name>A0A8C2YDF9_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxymethylenebutenolidase homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC107309513</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dienelactone hydrolase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2YDF9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005025553.1">
        <property type="protein sequence ID" value="ENSCJPP00005018334.1"/>
        <property type="gene ID" value="ENSCJPG00005014923.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000000183"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042946">
        <property type="entry name" value="CMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46812">
        <property type="entry name" value="CARBOXYMETHYLENEBUTENOLIDASE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46812:SF2">
        <property type="entry name" value="CARBOXYMETHYLENEBUTENOLIDASE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="4">
        <location>
            <begin position="60"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005018334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="207" mass="24015" checksum="DA7BA1A6494C9274" modified="2022-01-19" version="1">MADPFLYNTGERSGYGCLGHEVQIEHIKAYVSPIFPLFLLINGKDPWKTTDHWHDFADWMKEHDPMKVDREADVVLKYLKEQCGAKKIGIVGFSWGGMAVHHLMLKNPQLSAGVSLYGIIRDSEERYDLLNPTFFIFGEKDHTISHDQITLLDEKLKQYCKVPYKIKVYPGQVHGFAQLKPEDMKPVDKPYIEEARKDMIDWIKTFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YEG8</accession>
    <name>A0A8C2YEG8_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Spermidine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">SRM</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the spermidine/spermine synthase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2YEG8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005028312.1">
        <property type="protein sequence ID" value="ENSCJPP00005020532.1"/>
        <property type="gene ID" value="ENSCJPG00005016519.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00870000136521"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004766">
        <property type="term" value="F:spermidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990830">
        <property type="term" value="P:cellular response to leukemia inhibitory factor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000013">
        <property type="entry name" value="Spermidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00198">
        <property type="entry name" value="Spermidine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030374">
        <property type="entry name" value="PABS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030373">
        <property type="entry name" value="PABS_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001045">
        <property type="entry name" value="Spermi_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00417">
        <property type="entry name" value="speE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11558:SF11">
        <property type="entry name" value="SPERMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11558">
        <property type="entry name" value="SPERMIDINE/SPERMINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01564">
        <property type="entry name" value="Spermine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01330">
        <property type="entry name" value="PABS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51006">
        <property type="entry name" value="PABS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PABS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005020532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="266" mass="29266" checksum="2AFA6A485E4DA1CE" modified="2022-01-19" version="1">MHRAGRVLLPGDDRQPAALQPPGPSQGEAAPVGSFTPAPLPVPLLGVSSYPSGSFPPLPPQVLIIGGGDGGVLREVVKHPTVESVVQCEIDEDVIQVSKKYLPGMAVGYSSAKLTLHVGDGFEFMKQNQEAFDVIITDSSDPMGPAESLFKESYYQLMKTALREDGILCCQGECQWLHLDLIKEMRQFCKSLFPVVEYAYCTIPTYPSGQIGFMLCSKNPNTNFREPVQQLSQQQVEERSLKYYNSDIHRAAFILPEFARKALSDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YGU8</accession>
    <name>A0A8C2YGU8_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Coiled-coil domain containing 186</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CCDC186</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YGU8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005034774.1">
        <property type="protein sequence ID" value="ENSCJPP00005025574.1"/>
        <property type="gene ID" value="ENSCJPG00005020064.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00720000108851"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035773">
        <property type="term" value="P:insulin secretion involved in cellular response to glucose stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009617">
        <property type="term" value="P:response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099518">
        <property type="term" value="P:vesicle cytoskeletal trafficking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038830">
        <property type="entry name" value="CCDC186"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18911:SF5">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18911">
        <property type="entry name" value="CTCL TUMOR ANTIGEN HD-CL-01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="739"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="230"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="509"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="746"/>
            <end position="757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005025574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="926" mass="106270" checksum="B527180155E172B0" modified="2022-01-19" version="1">LKISQRNTMEEYSPGMQSTLEPVGLSEEASYQSSDSKKPSETSGMKDCSSINCTGGDAGVLEAEPRLSSLDQDSTAADMSGGGGLTERQEQQCAILDRSEGQDCGANTCSERRIEGSTETGCLSSEEFGGDPKTNQTEQSLIELLQELREESDFVRKSSDKIYSESPYDTDCTKKLISTIQQTSSQEDLLKEIESELLSTDFSKECKCPNGVRKGERALAVFDKCVQDKYLQQEQTIKKLIKENKKHQELILEICSEKDNLKDELKKRTETEKQHLNIIKQLEARIEELNKEVKTNKDKLVAQDAAAKNAIQQLHKEMAFRMEQANKKCEEARHEKETMVMKYVRGEKESLDLRKEKEILERRVRDANKEIEKHTNKIKQLSQEKGRLHQLYENKESEATRLNKEIEKLKEEINSHVIKVKWAQNKLKTEMDSHKESKERLKDATTKLTQAKEEADQIRKNCQEMIKTYQESEEIKSNELDVKFKVTKGELEKQMQEKSDHLEVPHAKIKELEDLKRTFKEGMDELRTLRTKVKCLEDERLRTEDELSKYKEIINRQKTEIQSLLDRVKTVDRLQDQHQRDEQDIGALKEEVDGLNSLIADLQKDIEGSRKRESELLIFTEKLTSKNAQLQSENNSLQSQLDKLSYSERELQNQLECVQQAKDDLVSVLQKEEDQRKLEVETLQAQLASEQKELTALKTHVDELKDELTTQKRKQAANLKDLTKQLQLARRKLDQIENGNYDKEVSSMGSRSSSSGSLNARSGNEDRSPENTGSSVAVDSFPEVDKSVLVERILRLQKAHARKNEKMEFMEDHIKHLVEEIRKKTKIIQSYILREEAGALSSEASDFNKVHLSRRGGIMASLYTSHPADSGLTLELSLEINRKLQAVLEDTLLKNITLKENLQTLGTEIERLIKHKHELEQKIKQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-01-11" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>E3UKE1</accession>
    <name>E3UKE1_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G0/G1 switch 2</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">G0/G1 switch protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">GOS2</name>
        <name evidence="3" type="synonym">G0S2</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="J. Anim. Sci." volume="89" first="367" last="375">
            <title>Cloning of avian G(0)/G(1) switch gene 2 genes and developmental and nutritional regulation of G(0)/G(1) switch gene 2 in chicken adipose tissue.</title>
            <authorList>
                <person name="Oh S.A."/>
                <person name="Suh Y."/>
                <person name="Pang M.G."/>
                <person name="Lee K."/>
            </authorList>
            <dbReference type="PubMed" id="20952523"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="HM448837">
        <property type="protein sequence ID" value="ADO85306.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015740881.1">
        <property type="nucleotide sequence ID" value="XM_015885395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E3UKE1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005028583.1">
        <property type="protein sequence ID" value="ENSCJPP00005020735.1"/>
        <property type="gene ID" value="ENSCJPG00005016651.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107324933"/>
    <dbReference type="KEGG" id="cjo:107324933"/>
    <dbReference type="CTD" id="50486"/>
    <dbReference type="GeneTree" id="ENSGT00390000005294"/>
    <dbReference type="OrthoDB" id="9373743at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097191">
        <property type="term" value="P:extrinsic apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120162">
        <property type="term" value="P:positive regulation of cold-induced thermogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001238">
        <property type="term" value="P:positive regulation of extrinsic apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016821">
        <property type="entry name" value="G0S2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15570">
        <property type="entry name" value="G0/G1 SWITCH PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15570:SF2">
        <property type="entry name" value="G0_G1 SWITCH PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15103">
        <property type="entry name" value="G0-G1_switch_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADO85306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005020735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="101" mass="11472" checksum="CDB1B5FDD8419E47" modified="2011-01-11" version="1">METMHELIPFAKEMLSQKPNRKMVKLYMLGSVLAFFGVVIGLVEAVCSPFTSEGRIEEEEEKRPNPSREPALPQKREDLVLEQSKKSSVVQRGMVTRQHAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SLG2</accession>
    <name>A0A8C2SLG2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">High mobility group protein B3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">HMGB3</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HMGB family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015716294.1">
        <property type="nucleotide sequence ID" value="XM_015860808.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SLG2"/>
    <dbReference type="SMR" id="A0A8C2SLG2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005000094.1">
        <property type="protein sequence ID" value="ENSCJPP00005000041.1"/>
        <property type="gene ID" value="ENSCJPG00005000075.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107312948"/>
    <dbReference type="KEGG" id="cjo:107312948"/>
    <dbReference type="CTD" id="3149"/>
    <dbReference type="GeneTree" id="ENSGT00940000153299"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045578">
        <property type="term" value="P:negative regulation of B cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045638">
        <property type="term" value="P:negative regulation of myeloid cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd21978">
        <property type="entry name" value="HMG-box_HMGB_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21979">
        <property type="entry name" value="HMG-box_HMGB_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000013">
        <property type="entry name" value="High mobility group protein B3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000017">
        <property type="entry name" value="high mobility group protein B3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017967">
        <property type="entry name" value="HMG_boxA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF32">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN B3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09011">
        <property type="entry name" value="HMG_box_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00886">
        <property type="entry name" value="HIGHMOBLTY12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00353">
        <property type="entry name" value="HMG_BOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12 17" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0391">Immunity</keyword>
    <keyword evidence="7" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="15 17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-0558">Oxidation</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="14" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HMG box" evidence="19">
        <location>
            <begin position="9"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="HMG box" evidence="19">
        <location>
            <begin position="93"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="17">
        <location>
            <begin position="9"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="17">
        <location>
            <begin position="93"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="71"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="161"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00073418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005000041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="202" mass="23057" checksum="24222C692BC5C903" modified="2022-01-19" version="1">MAKGDPKKPKGKMSAYAFFVQTCREEHKKKNPEVPVNFAEFSKKCSERWKTMSSKEKAKFDEMAKADKVRYDREMKDYGPAKGGKKKKDPNAPKRPPSGFFLFCSEFRPKIKSTNPGISIGDVAKKLGEMWNNLSDGEKQPYNNKAAKLKEKYEKDVADYKSKGKFDGAKGAATKAARKKVEEEDEEEEEDEEEEDEDDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SLK1</accession>
    <name>A0A8C2SLK1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">N-terminal EF-hand calcium-binding protein 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Neuronal calcium-binding protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">NECAB2</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">May act as a signaling scaffold protein that senses intracellular calcium. Can modulate ligand-induced internalization of ADORA2A and coupling efficiency of mGluR5/GRM5; for both receptors may regulate signaling activity such as promoting MAPK1/3 (ERK1/2) activation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Interacts (calcium-dependent) with ADORA2A and GRM5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Axon</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Dendrite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SLK1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005001119.1">
        <property type="protein sequence ID" value="ENSCJPP00005000622.1"/>
        <property type="gene ID" value="ENSCJPG00005000709.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183131"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031687">
        <property type="term" value="F:A2A adenosine receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031802">
        <property type="term" value="F:type 5 metabotropic glutamate receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904021">
        <property type="term" value="P:negative regulation of G protein-coupled receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060168">
        <property type="term" value="P:positive regulation of adenosine receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070374">
        <property type="term" value="P:positive regulation of ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900451">
        <property type="term" value="P:positive regulation of glutamate receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905477">
        <property type="term" value="P:positive regulation of protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042984">
        <property type="term" value="P:regulation of amyloid precursor protein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000334">
        <property type="entry name" value="N-terminal EF-hand calcium binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000028">
        <property type="entry name" value="N-terminal EF-hand calcium-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039862">
        <property type="entry name" value="NECAB1/2/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12178">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12178:SF2">
        <property type="entry name" value="N-TERMINAL EF-HAND CALCIUM-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0488">Methylation</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="19">
        <location>
            <begin position="138"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="19">
        <location>
            <begin position="174"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="ABM" evidence="20">
        <location>
            <begin position="365"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="33"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="18">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00055498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00064445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00070335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00081394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005000622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="492" mass="53481" checksum="B2E56CC8EC8559BC" modified="2022-01-19" version="1">MTSLAFWAVGSEPILGFLARILKSCSGRELRGVLGPPPQNLRAGQSEEAGTRPWPRCGGGGREGGGGGGSPGSGTRPGGAMCEQAARYCRAGVHRLLRKPAPALRGLDGLLRWVGARMSDKGVADRELLSSGASAQRKGTSVILDIFRRADKNDDGKLSLEEFQAFFSDGTLNEEELEKLFHTIDSDNTNNVDTKELCDYFADHMGDYEDVLASLETLNLSILKAMDYTKRVYESGSNVDQFVTRFLLKETANQTQSLLSSVESAVDAIDEQTNPSRQCPGPAGLALTEPWYNSPVPSYAPPARIVPQGHGKSSQSGAPEPRQDGLEGQIGRLAALISRLEDKTLWFDLHQRLSDSESTACMYLLLVRDEMTVSHKHLGEFCSSLKQYLKSVAGMRECFHVTAVKLPDGVTFIVYEFWETEDDWKRHLQSATCKDFQHVKVDALSQPEAISSVAVPGRTRGRGTKQPLGSGEQSGWCSWGGMCAAVTLGDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SMR1</accession>
    <name>A0A8C2SMR1_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Methyl-CpG binding domain protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">MBD2</name>
        <name evidence="10" type="synonym">LOC107307002</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SMR1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005001868.1">
        <property type="protein sequence ID" value="ENSCJPP00005001087.1"/>
        <property type="gene ID" value="ENSCJPG00005001157.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183005"/>
    <dbReference type="OrthoDB" id="10072024at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000792">
        <property type="term" value="C:heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016581">
        <property type="term" value="C:NuRD complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070742">
        <property type="term" value="F:C2H2 zinc finger domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008327">
        <property type="term" value="F:methyl-CpG binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035197">
        <property type="term" value="F:siRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006346">
        <property type="term" value="P:DNA methylation-dependent constitutive heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042711">
        <property type="term" value="P:maternal behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030177">
        <property type="term" value="P:positive regulation of Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065003">
        <property type="term" value="P:protein-containing complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042127">
        <property type="term" value="P:regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01396">
        <property type="entry name" value="MeCP2_MBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.890.10:FF:000003">
        <property type="entry name" value="methyl-CpG-binding domain protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.890.10">
        <property type="entry name" value="Methyl-cpg-binding Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016177">
        <property type="entry name" value="DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032343">
        <property type="entry name" value="MBD2/MBD3_p55-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025884">
        <property type="entry name" value="MeCpG-bd_2/3_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001739">
        <property type="entry name" value="Methyl_CpG_DNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12396">
        <property type="entry name" value="METHYL-CPG BINDING PROTEIN, MBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12396:SF5">
        <property type="entry name" value="METHYL-CPG-BINDING DOMAIN PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01429">
        <property type="entry name" value="MBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14048">
        <property type="entry name" value="MBD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16564">
        <property type="entry name" value="MBDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00391">
        <property type="entry name" value="MBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54171">
        <property type="entry name" value="DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50982">
        <property type="entry name" value="MBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MBD" evidence="9">
        <location>
            <begin position="2"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005001087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="259" mass="28679" checksum="30C9D2CC5A1D65E3" modified="2022-01-19" version="1">MEKQGRVDCPALPPGWKKEEVIRKSGLSAGKSDVYYFSPTGKKFRSKPQLARYLGNAVDLSCFDFRTGKMMPSKLQKNKQRLRGDAMQANKGKPDLNTALPIRQTASIFKQPVTKVTNHPDNKVRADPQRLAEQPRQLFWEKRLRGLSASDVGQEILKAMELPKGLQALGPVPDDVTLLSAVASALHVGSVPVTGQISSAAEKNPSVWLNSSQPLCKAFLVTDDDIRKQEERVRRVRKKLEEALLANEPATGSKGHEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SMR5</accession>
    <name>A0A8C2SMR5_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="22">Potassium voltage-gated channel subfamily C member 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">KCNC3</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Presynaptic cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SMR5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005001871.1">
        <property type="protein sequence ID" value="ENSCJPP00005001090.1"/>
        <property type="gene ID" value="ENSCJPG00005001156.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163131"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043679">
        <property type="term" value="C:axon terminus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032590">
        <property type="term" value="C:dendrite membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032809">
        <property type="term" value="C:neuronal cell body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005251">
        <property type="term" value="F:delayed rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030866">
        <property type="term" value="P:cortical actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051262">
        <property type="term" value="P:protein tetramerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd18414">
        <property type="entry name" value="BTB_KCNC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000011">
        <property type="entry name" value="Potassium channel, voltage-gated Shaw-related subfamily C, member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000014">
        <property type="entry name" value="Potassium channel, voltage-gated Shaw-related subfamily C, member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000002">
        <property type="entry name" value="Potassium voltage-gated channel subfamily C member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003968">
        <property type="entry name" value="K_chnl_volt-dep_Kv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003974">
        <property type="entry name" value="K_chnl_volt-dep_Kv3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF252">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01491">
        <property type="entry name" value="KVCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01498">
        <property type="entry name" value="SHAWCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0966">Cell projection</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16" id="KW-0407">Ion channel</keyword>
    <keyword evidence="12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-0630">Potassium</keyword>
    <keyword evidence="7" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0770">Synapse</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="392"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="21">
        <location>
            <begin position="8"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="430"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="19">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="450"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00034111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005001090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="547" mass="60377" checksum="EECBC2122D9FEC3C" modified="2022-01-19" version="1">MGWQAERDKVVINVGGVRHETYRSTLQTLPGTRLACLAEPGAASRFDYDSVAGEFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDSFESPETNDGGDGGNGDGNGTELKRLCLDEGRPGGWWRRWRPRVWALFEDPYSSRMARYVAFASLFFILISITTFCLETHEAFNRVINKTESIPVGNGTASPVAVVEVETEPFLTYVEGTCVVWFTFEFLMRVSFCPDKRDFIKSSLNIIDFVAILPFYLEVGLRGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLVIFLALGVLIFATMIYYADDPTHFKNIPIGFWWAVVTMTTLGYGDMYPMTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKNKHIPRPPQPGSPGYGPPTTTGSPAGSHPHNRGPIPHNRVGVPSPIIGVPSPYRGPIPIIGVPSPIIGVPIPIIGLPSPIIGVPIPIIGVPIPHNRGPIPIIGVPIPIIGVPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SQ33</accession>
    <name>A0A8C2SQ33_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ALF transcription elongation factor 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">AFF3</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AF4 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SQ33"/>
    <dbReference type="Ensembl" id="ENSCJPT00005002012.1">
        <property type="protein sequence ID" value="ENSCJPP00005001170.1"/>
        <property type="gene ID" value="ENSCJPG00005001212.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182974"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032783">
        <property type="term" value="C:super elongation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035116">
        <property type="term" value="P:embryonic hindlimb morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034612">
        <property type="term" value="P:response to tumor necrosis factor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007797">
        <property type="entry name" value="AF4/FMR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043640">
        <property type="entry name" value="AF4/FMR2_CHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10528">
        <property type="entry name" value="AF4/FMR2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10528:SF16">
        <property type="entry name" value="AF4_FMR2 FAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05110">
        <property type="entry name" value="AF-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18876">
        <property type="entry name" value="AFF4_CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AF4/FMR2 C-terminal homology" evidence="6">
        <location>
            <begin position="972"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="166"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="421"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="799"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="886"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1109"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="189"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="208"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="438"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="461"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="522"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="597"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="679"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="800"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="838"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="902"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1109"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1135"/>
            <end position="1154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005001170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1232" mass="134270" checksum="83BCBA55717FB7C8" modified="2022-01-19" version="1">MTLIYVSTLQIYSARRKALAELGKIGNSSECPEITSKADGIHWLSFDENKAYRRKCVNLCCFEEIWGKDSLVYEPDRNVLRRKEWERRNQEAQQEDGTFNTSYSLFSEPYKTNKGDELSNRIQNTLGNYDEMKDLLTDRSNQSHLVGVPKPGVPQTALSKPDELLIAESRPPPPPSISNATSAPAALPAQQSKSTTMGWQKAGHNAASEGQQRQSSLRATLGDSVSRVQQPAKLNCGSEGGAQVQERPSKHSGGHCVQNFPPSLASKPSLVQQKPTAYVRPMDGQDQAPDESPKLKLLTETTKLYRGVPSNKTDSARTKSKITKFNIPKQEEDSGTGDNSCIEEILREMTHSWPPPLTAIHTPGKAEQSKFPFPNKVRDVRAYTFKYDFMSKLTNRYAPNTVWFLSVSLCLFSLLPSHSHGPSSLVGPQSSTRAPGLSSKGSSSSSSSESESSSESDSESESSSSESDGSKPSHYSSPEPEPPSSNKWQLDKWLNKVTPHKAPILTHHDASALEAHPYYGHVKAERQEDEKTPTPGPAEHRAGDSRTAAPSTAATVGDGPRPRTANKAPGSKGGRQKSPPAADCGPPRRAAGKKAPRRAERTSVGDGSHCRGAEEPAGSHGFLEGAGSEAPRARPAASVGGAGCRAGHRREPRSAAAGEKRRARGPSKTAPKSKEFIETESSSSSSSSESGSESEREERPLPKAQAAAGAEPHAKDLGTGAASKAHGGCSAFGSINARTNSEIAKELEEQFYTLVPFGRNELLSPLKDSDEVKSLWVNIDLALLSRIPERLPEEPLAMSAGTNQAASIPQGSSADLPAEKGLPKSRRKRKCENEEEYRDTKKTHLERESSSRLAASAHSITTANHCNMNENSLALPINKNEKVLRSPVSPLSDASKHKYSSDDLTSSSRPNGSSLLPSISSSKKHKGEIQSQPHLGDFNKAVHTNSENVLLCNKPQTQTEPWSPLSSAPRDCRRTKLIFDDMPRNADYFMQEAKRKKHKADAMVEKFGKALNYAEAALSFIECGNALEKNAQESKSPFTMYSETVELIKYAVRLKTHSGPNATPEDKQLAALCYRCLALLYWRMFRLKRDHAVKYSKALIEYFKNSSKAAQNPSSWGNSGKSTGTPSPMSPSPSPVSSVGSQGSTGPPSSSPIISIPQRIHQMAANHVSITNSILHSYDYWEMADNLAKENREFFNDLDALMGPITLHSSMEHLVQYTQQGLHWVRNSTHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SR02</accession>
    <name>A0A8C2SR02_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SR02"/>
    <dbReference type="Ensembl" id="ENSCJPT00005004507.1">
        <property type="protein sequence ID" value="ENSCJPP00005002447.1"/>
        <property type="gene ID" value="ENSCJPG00005002702.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183066"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051023">
        <property type="entry name" value="PP2A_Regulatory_Subunit_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A 65 KDA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648:SF2">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A 65 KDA REGULATORY SUBUNIT A ALPHA ISOFORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="328"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="475"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="510"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="574"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="614"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005002447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="643" mass="70036" checksum="183ECE9F17E83F7F" modified="2022-01-19" version="1">MAAADGDDSLYPIAVLIDELRNEDVQVPTWRLRAVTKPLPVGLYRRLLPMGSDTIYDEDEVLLALAEQLGTFTALVGGPEFVHCLLPPLEIRGVTTFAVSHEHSPADLEGHFVPLVKRLAGGDWFHVPHSACGLFQGGLLPQGLQPRSRPSSGSEWPIWGQYVAIGGHIGVYGVIGGHIGPFIGSFKGPILGPWWPYCVLYWVFGAILGSFGGHGGQYEDSVRLLAVEACVNIAQLLPQDDLESLVMPTLRQAEPHRTHMRYMVADKFTELQKAVGPEITKTDLVGAFQNLMKDCEATRSGRPRPIKSKVNPWLPSGIGRLTNNVKSALASVIMGLSPILGGLWGAHLLPLFLAQLKDEGTGMDWAILWGRCGRHSMFLVHTGPYWSILVHTGPYWSILVHTGFSQGVEFFDEKLNSLCMAWLVDHVYAIREAATSNLRKLVERFGQDWAQGTIVPKVLAMATDPNYLHRMTTLFCINVSSVPMGLYGSLCVPMYPYVSLCVPMGPYVSLWVPMCLYVSLWVPMGSLCVPICPYGVSMWVPPHSTLQNEVKPVLEKLTQDQDVDVKYFAQEMGAMGVLGLSWGIFGAYLGLWVNGEYWGQMGALGGNGPMVGNWANGVWVSGGIGVNGGIVVSGGYLGSGGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SR08</accession>
    <name>A0A8C2SR08_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methylated-DNA--protein-cysteine methyltransferase</fullName>
            <ecNumber evidence="6">2.1.1.63</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">6-O-methylguanine-DNA methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">O-6-methylguanine-DNA-alkyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">MGMT</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:53428"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13555"/>
            <dbReference type="Rhea" id="RHEA-COMP:13556"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:137386"/>
            <dbReference type="ChEBI" id="CHEBI:137387"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = S-methyl-L-cysteinyl-[protein] + a 2'-deoxyguanosine in DNA</text>
            <dbReference type="Rhea" id="RHEA:24000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:11367"/>
            <dbReference type="Rhea" id="RHEA-COMP:11368"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:85445"/>
            <dbReference type="ChEBI" id="CHEBI:85448"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MGMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.63" evidence="6"/>
    <dbReference type="RefSeq" id="XP_015723104.1">
        <property type="nucleotide sequence ID" value="XM_015867618.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SR08"/>
    <dbReference type="Ensembl" id="ENSCJPT00005002150.1">
        <property type="protein sequence ID" value="ENSCJPP00005001256.1"/>
        <property type="gene ID" value="ENSCJPG00005001320.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107316303"/>
    <dbReference type="KEGG" id="cjo:107316303"/>
    <dbReference type="CTD" id="4255"/>
    <dbReference type="GeneTree" id="ENSGT00390000015799"/>
    <dbReference type="OrthoDB" id="1907495at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000781">
        <property type="term" value="P:positive regulation of double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000214">
        <property type="entry name" value="Methylated-DNA--protein-cysteine methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.70:FF:000001">
        <property type="entry name" value="Methylated-DNA--protein-cysteine methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.70">
        <property type="entry name" value="Methylated DNA-protein cysteine methyltransferase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001497">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008332">
        <property type="entry name" value="MethylG_MeTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036631">
        <property type="entry name" value="MGMT_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00589">
        <property type="entry name" value="ogt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46460">
        <property type="entry name" value="METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46460:SF1">
        <property type="entry name" value="METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02870">
        <property type="entry name" value="Methyltransf_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53155">
        <property type="entry name" value="Methylated DNA-protein cysteine methyltransferase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="Methylated DNA-protein cysteine methyltransferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00374">
        <property type="entry name" value="MGMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Methylguanine DNA methyltransferase ribonuclease-like" evidence="21">
        <location>
            <begin position="21"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding" evidence="20">
        <location>
            <begin position="112"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00015377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00030795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00031621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF02870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005001256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="197" mass="21668" checksum="C553303409ABC1FC" modified="2022-01-19" version="1">MASRHVPKMTSKEGSSQCQVKHAVLLSPVGKLEISGCEKGIHEVKLPKLSVLPNGTEAPVCCELRGNVTSMPEPLQQCAAWLSAYFCEPSRTKQLPLPPFHHPMLLQDSFTKEVLWTLLREVKFGEAISYQQLAERAGNSRAARAVGGAMRNNPIAIIIPCHRVICSSGQIGNYGGGILMKEWLLSHEKLQKEKLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SR51</accession>
    <name>A0A8C2SR51_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">GABA(C) receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">GABRR3</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>chloride(in) = chloride(out)</text>
            <dbReference type="Rhea" id="RHEA:29823"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Postsynaptic cell membrane</location>
            <topology evidence="17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SR51"/>
    <dbReference type="Ensembl" id="ENSCJPT00005001413.1">
        <property type="protein sequence ID" value="ENSCJPP00005000807.1"/>
        <property type="gene ID" value="ENSCJPG00005000869.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159906"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098982">
        <property type="term" value="C:GABA-ergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19005">
        <property type="entry name" value="LGIC_ECD_GABAAR_rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19059">
        <property type="entry name" value="LGIC_TM_GABAAR_rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000007">
        <property type="entry name" value="Gamma-aminobutyric acid type A receptor rho2 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000005">
        <property type="entry name" value="Putative gamma-aminobutyric acid receptor subunit rho-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0868">Chloride</keyword>
    <keyword evidence="10" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14 18" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 18" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 18" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="435"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="19">
        <location>
            <begin position="52"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="20">
        <location>
            <begin position="260"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00024167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005000807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="453" mass="52712" checksum="22A74B2669990699" modified="2022-01-19" version="1">LPRSHWLWNYTTGSMWLNASARYDLIYKRDIKMRKLDSTKVRPLKSEQLLRIEDHDFALRPGFGGSPIPVGIDVQVESIDSISEVDMDFTMTLYLRHYWKDERLSFPSTNNKSMTFDGRLIKKIWVPDVFFVHSKRSFIHDTTVENVMLRVYPDGNVLFSLRITVSAMCFMDFSRFPLDTQNCSLELESYAYNEDDLMLYWKHGNESLSTDEHISLSQFFIEEFSASSGLAFYSSTGWYNRLFINFALRRHIFFFVLQSYFPAMLMVMLSWVSFWIDRRAVPARVSLGITTVLTMSTIITGVSASMPQVSYIKAVDVYLWISFLFVFLSVIEYAAVNYLTTIEERKQLKKRGKASGMYNIDAVQAMAFDGCYHDPDVEMDLPAFTDRCEENETRARAVSVSNVGTARIKRKRSFKGNVGRIILQNNHVIDTYSRIIFPSVYIVFNFFYWGLYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SSA4</accession>
    <name>A0A8C2SSA4_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SSA4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005004588.1">
        <property type="protein sequence ID" value="ENSCJPP00005002499.1"/>
        <property type="gene ID" value="ENSCJPG00005002757.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159880"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030020">
        <property type="term" value="F:extracellular matrix structural constituent conferring tensile strength"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050149">
        <property type="entry name" value="Collagen_superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023:SF1095">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005002499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="152" mass="14765" checksum="5D79C58FE50AB8A9" modified="2022-01-19" version="1">RGYPGSHHTHNPPTLLALRFRSSSTTGRYREESDRGGSQGLVGPVGPAGLVGPTGFIGPTGLVGRIGLVGPVGFVGFVGPAGLVGLIGLVGPAGLIGLVGFVGLVGPAGLVGLIGLTGLVGLTGLVGLIGLVGPVGLVGPVGPVPHTHYRPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SSF5</accession>
    <name>A0A8C2SSF5_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DEAH-box helicase 16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">DHX16</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SSF5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005003001.1">
        <property type="protein sequence ID" value="ENSCJPP00005001785.1"/>
        <property type="gene ID" value="ENSCJPG00005001685.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158480"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071005">
        <property type="term" value="C:U2-type precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038187">
        <property type="term" value="F:pattern recognition receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140374">
        <property type="term" value="P:antiviral innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:004188">
        <property type="entry name" value="Adenosinetriphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF83">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE DHX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="394"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="488"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="69"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="269"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="208"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="160"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005001785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="784" mass="89132" checksum="B1081573363C2B05" modified="2022-01-19" version="1">MATKPMAAALERWVAEELQELLGMSGRHVPAFLVALAKRSRNVEDLLDRLRETEALKVEEPRVREFARELWGKIPRDPPKEPPGRAAERAALELQRRSRGYRPIESDEEGDGGSSEPTPTPQRRRHLRRRQRSESPENDTETAPEPAEDPSEEPEAEWEASERERLRDLEERDAFAERLRRRDRHRTRNVLTRPDAKVLGGVPELRKKSRREYLAKREKDKLEELEAEIADEEYLFGEETLTSSERRELEYKRRVRDLAKEYKRAGEKEKLEKSNRYYMPEESRDKREDPSTEEERLAPRDEQRRWEEERMGAASLRFGARDAAQRRPPPNYDFILEEDEMIQFVSAVQMQGTEPEKVNRGGMGVCGGEMGVLGGGYGWERKVGSGSGVGIWAYFEGWLMVGYSIRFEDCTSERTLLKYMTDGMLLREFLTEPDLASYSVIMVDEAHERTLHTDVLFGLVKDIARFRPELKVLVASATLDTQRFSTFFDDAPVFRIPGRRFPVDIYYTKEEIEACVELLQERCRRLGSKMAELLVLPIYANLPSDMQARIFEPTPPGARKVVVATNIAETSLTIDGIVYVLDPGFCKQKSYSARTGMESLIVTPCSRASANQRAGRAGRVAPGKCFRLYTAWAFQHELEETAVPEIQRADLGCLVLLLKSLGVSTCYFLDPPHEACCCAAERALRTGALNHLGSSPTYLGRRMAELPVEPMLAKMILASEQYGCTEEVLTVAAMLSVNNAVFYRPKDRVLHADSARLGFHIPGGDHLVLLNVYNQVGVWGGYGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SSN6</accession>
    <name>A0A8C2SSN6_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RNA polymerase-associated protein CTR9 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">SH2 domain-binding protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">CTR9</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015719464.1">
        <property type="nucleotide sequence ID" value="XM_015863978.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SSN6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005005781.1">
        <property type="protein sequence ID" value="ENSCJPP00005003212.1"/>
        <property type="gene ID" value="ENSCJPG00005002727.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107314593"/>
    <dbReference type="KEGG" id="cjo:107314593"/>
    <dbReference type="CTD" id="9646"/>
    <dbReference type="GeneTree" id="ENSGT00390000005097"/>
    <dbReference type="OrthoDB" id="343875at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000791">
        <property type="term" value="C:euchromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042169">
        <property type="term" value="F:SH2 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007259">
        <property type="term" value="P:cell surface receptor signaling pathway via JAK-STAT"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071222">
        <property type="term" value="P:cellular response to lipopolysaccharide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001711">
        <property type="term" value="P:endodermal cell fate commitment"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070102">
        <property type="term" value="P:interleukin-6-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045814">
        <property type="term" value="P:negative regulation of gene expression, epigenetic"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045638">
        <property type="term" value="P:negative regulation of myeloid cell differentiation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:stem cell population maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000089">
        <property type="entry name" value="CTR9 homolog, Paf1/RNA polymerase II complex component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000162">
        <property type="entry name" value="CTR9 homolog, Paf1/RNA polymerase II complex component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001026">
        <property type="entry name" value="CTR9 homolog, Paf1/RNA polymerase II complex component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031101">
        <property type="entry name" value="Ctr9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14027">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN CTR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14027:SF2">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN CTR9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="198"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="341"/>
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        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="497"/>
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        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="531"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="893"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="828"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="900"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="917"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="980"/>
            <end position="994"/>
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        <location>
            <begin position="1023"/>
            <end position="1034"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
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            <begin position="1045"/>
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            <begin position="1065"/>
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            <begin position="1107"/>
            <end position="1116"/>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SSR0</accession>
    <name>A0A8C2SSR0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ribonuclease III</fullName>
            <ecNumber evidence="5">3.1.26.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="29" type="primary">DICER1</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="29" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="29" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="20 21">Belongs to the helicase family. Dicer subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.3" evidence="5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005004149.1">
        <property type="protein sequence ID" value="ENSCJPP00005002299.1"/>
        <property type="gene ID" value="ENSCJPG00005002499.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156287"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070062">
        <property type="term" value="C:extracellular exosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016442">
        <property type="term" value="C:RISC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070578">
        <property type="term" value="C:RISC-loading complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004530">
        <property type="term" value="F:deoxyribonuclease I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070883">
        <property type="term" value="F:pre-miRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035197">
        <property type="term" value="F:siRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006309">
        <property type="term" value="P:apoptotic DNA fragmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098795">
        <property type="term" value="P:global gene silencing by mRNA cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032720">
        <property type="term" value="P:negative regulation of tumor necrosis factor production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010804">
        <property type="term" value="P:negative regulation of tumor necrosis factor-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031054">
        <property type="term" value="P:pre-miRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070922">
        <property type="term" value="P:RISC complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="DEXHc_dicer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15903">
        <property type="entry name" value="Dicer_PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10843">
        <property type="entry name" value="DSRM_DICER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02843">
        <property type="entry name" value="PAZ_dicer_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd18802">
        <property type="entry name" value="SF2_C_dicer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1520.10:FF:000023">
        <property type="entry name" value="Endoribonuclease dcr-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000015">
        <property type="entry name" value="endoribonuclease Dicer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000628">
        <property type="entry name" value="Endoribonuclease Dicer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.380:FF:000002">
        <property type="entry name" value="Endoribonuclease Dicer isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000588">
        <property type="entry name" value="Endoribonuclease Dicer isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1520.10:FF:000005">
        <property type="entry name" value="Putative endoribonuclease dicer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.260.10:FF:000002">
        <property type="entry name" value="Putative Endoribonuclease Dicer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.380">
        <property type="entry name" value="Dicer dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038248">
        <property type="entry name" value="Dicer_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005034">
        <property type="entry name" value="Dicer_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044441">
        <property type="entry name" value="DICER_DSRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048513">
        <property type="entry name" value="Dicer_PBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048512">
        <property type="entry name" value="Dicer_platform"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950">
        <property type="entry name" value="DICER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950:SF37">
        <property type="entry name" value="ENDORIBONUCLEASE DICER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03368">
        <property type="entry name" value="Dicer_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20932">
        <property type="entry name" value="Dicer_dsRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20930">
        <property type="entry name" value="Dicer_PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20931">
        <property type="entry name" value="Dicer_platform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00949">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51327">
        <property type="entry name" value="DICER_DSRBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="14" id="KW-0347">Helicase</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="19" id="KW-0464">Manganese</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="17 21" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="18" id="KW-0943">RNA-mediated gene silencing</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="26">
        <location>
            <begin position="51"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="27">
        <location>
            <begin position="433"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="Dicer dsRNA-binding fold" evidence="28">
        <location>
            <begin position="630"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="domain" description="PAZ" evidence="25">
        <location>
            <begin position="895"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="24">
        <location>
            <begin position="1285"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="24">
        <location>
            <begin position="1675"/>
            <end position="1833"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="23">
        <location>
            <begin position="1858"/>
            <end position="1923"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="409"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="727"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1792"/>
            <end position="1811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="22">
        <location>
            <begin position="414"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012177"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
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            <dbReference type="ARBA" id="ARBA00022759"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00035116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
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            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
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    </evidence>
    <evidence type="ECO:0000259" key="26">
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS51327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005002299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1931" mass="219660" checksum="0C48531923508C43" modified="2022-01-19" version="1">MKSPALQSLSMAGLQLMTPASSPMGPFFGLPWQQEAIHDNIYTPRKYQVELLEAALDHNTIVCLNTGSGKTFIAVLLTKELSYQIRGDFNKNGKRTVFLVNSANQVAQQVSAVRTHSDLKVGEYSSLEVTESWTKEKWSQEFSKHQVLVMTCHVALTVLRNEYLSLSNINLLVFDECHLAIQDHPYREIMKICEDYPSCPRILGLTASILNGKCDPAELEEKIKKLEKILKSNAETATDLVVLDRYTSQPCEIVVDCGPYTDKSGLYGRLLRELDEALHFLNDCNISVHSKERDSTLISKQILSDCRAVLVVLGPWCADKVAGMMVRELQKYIKHEQEELHRKFLLFTDTFLRKIHALCEEHFSPASLDLKFVTPKVIKLLEILRKYKPYERQQFESVEWYNNRNQDNYVSWSDSEDDDEDEEIEEKEKPETNFPSPFTNILCGIIFVERRYTAVVLNRLIKEAGKQDPELSYISSNFITGHGIGKNQPRNKQMEVEFRKQEEVLRKFRAHETNLLIATSIVEEGVDIPKCNLVVRFDLPTEYRSYVQSKGRARAPISNYIMLADTDKIKSFEEDLKTYKAIEKILRNKCSKSVDTSETETEPIVDDDDVFPPYVLRTDENSPRVTINTAIGHINRYCARLPSDPFTHLAPKCKTRELPDHTFYSTLYLPINSPLRASIVGPPMSCARLAERVVALICCEKLHKIGELDDHLMPVGKETVKYEEELDLHDEEETSVPGRPGSTKRRQCYPKAIPECLRDSYPKPDQPCYLYVIGMVLTTPLPDELNFRRRKLYPPEDTTRCFGILTAKPIPQIPHFPVYTRSGEVTISIELKKSGFTLSLQMLELITRLHQYIFSHILRLEKPALEFKPTEADSAYCVLPLNVVDDSSTLDIDFKFMEDIEKSEARTGIPSTQYTKEMPFIFKLEDYQDAVIIPRYRNFDQPHRFYVADVYTDLTPLSKFPSPEYETFAEYYKTKYNLDLTNLNQPLLDVDHTSSRLNLLTPRHLNQKGKALPLSSAEKRKAKWESLQNKQILVPELCAIHPIPASLWRKAVCLPSILYRLHCLLTAEELRAQTATDAGVGVKSLPADFRYPNLDFGWKKSIDSKSFISIPSSSLVENENYCKHSTIVVPENAAHQGANRTSSAEKHDQMSVSYRTLLDESPSKLQIDVSAELAAINGVSYNKNLANGNCDLVNRDFCQGNQLNYCRQEIPVQPTTSYPIQNLYSSENQPKPSNECTLLSNKYLDGNANRSTSDGCPKMTVTTSTSTAINVSKDKVDSEKNTSSGYSSKTLGPNPGLILQALTLSNASDGFNLERLEMLGDSFLKHAITTYLFCTYPDAHEGRLSYMRSKKVSNCNLYRLGKKKGLPSRMVVSIFDPPVNWLPPGYIVNQDKSNTDKWEKDETCERQCAGGVRTKENLLANGKLDYDDDDEEDEDLMWRLPKEETDFEDDFLEYDQEHIKFIDSMLMGSGAFVKKISLSHFSTTDSNYEWKAPKKSSLGNVPFSSDFDDFDYSSWDAMCYLDPSKAVEEDDFVVGFWNPSEENCGVDAGKQSISYDLHTEQCIADKSIADCVEALLGCYLTSCGERAAQLFLCSLGLKVLPVIKKTDWESTLCATGENCNSELKNLSPNSVSTCIVNSEPSLYKDLEYGCLKIPPRCMFDHPDAEKTLNHLISGFENFEKKINYSFKNKAYLLQAFTHASYHYNTITDCYQRLEFLGDAILDYLITKHLYEDPRQHSPGVLTDLRSALVNNTIFASLAVKYDYHKYFKAVSPELFHVIDDFVQFQMEKNEMQGMDSELRRSEEDEEKEEDIEVPKAMGDIFESLAGAIYMDSGMSLEMVWQVYYPMMRPLIEKFSANVPRSPVRELLEMEPETAKFSPAERTYDGKVRVTVEVVGKGKFKGVGRSYRIAKSAAARRALRSLKANQPQVPNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SSS7</accession>
    <name>A0A8C2SSS7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Inverted formin-2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SSS7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005005023.1">
        <property type="protein sequence ID" value="ENSCJPP00005002703.1"/>
        <property type="gene ID" value="ENSCJPG00005003016.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155691"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46345">
        <property type="entry name" value="INVERTED FORMIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46345:SF5">
        <property type="entry name" value="INVERTED FORMIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02205">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51082">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FH2" evidence="4">
        <location>
            <begin position="1"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="WH2" evidence="3">
        <location>
            <begin position="248"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="265"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="347"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="201"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="282"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="347"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="365"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="421"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005002703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="446" mass="50128" checksum="0370FED71D8F5A42" modified="2022-01-19" version="1">MLICEETTVVLDMIQPKAEAIRKACEDLLTSHRLPLFCKLILKVGNFLNYGSHTGDADGFKISTLLKLTETKANQTRITLLHHILEEVENSHTDLLELPEDLEYVSKAAGINLDIIRSESSANLKKLLELQRKVSSANDDVKQQYEKPIQDSIDASRKLEEDFETIDRKREELANYLCEDPSKLSLEDVFSTMKTFRDLFIRALKENKDRKEQAAKAEKRKKQLEEEEGRKWKIKKGLVKQEDVCVIDALLADIRKGFTLRKTKNRHESDALPKTLPAEIPEESRSGKDTDPTVPAAISSHLSLSLSQVHRPSSFWEQLNGSISEEQDNKRSGDGLESCRLAQDIQLSQNGGNSSTPSTPCDGAHQAELKEMAKENEDPGTDSLLDTSQEKSFSEEPATDSSCSATLPPGETHTDREKQRTSGKRRKKKRNSKSHSGILYSPWALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SU96</accession>
    <name>A0A8C2SU96_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Adhesion G protein-coupled receptor F2</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SU96"/>
    <dbReference type="Ensembl" id="ENSCJPT00005004685.1">
        <property type="protein sequence ID" value="ENSCJPP00005002541.1"/>
        <property type="gene ID" value="ENSCJPG00005002798.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162401"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000058">
        <property type="entry name" value="Adhesion G protein-coupled receptor F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051587">
        <property type="entry name" value="Adhesion_GPCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008078">
        <property type="entry name" value="GPCR_2_Ig-hepta-like_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45813:SF1">
        <property type="entry name" value="ADHESION G PROTEIN-COUPLED RECEPTOR F4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45813">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01695">
        <property type="entry name" value="IGHEPTARCPTR"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50221">
        <property type="entry name" value="GAIN_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="405"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="448"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="488"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="518"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="565"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="613"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="638"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="domain" description="GAIN-B" evidence="10">
        <location>
            <begin position="258"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="11">
        <location>
            <begin position="406"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005002541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="673" mass="73729" checksum="E747645153BE6C84" modified="2022-01-19" version="1">CWHSAFCAATPLLSVSPVGPVRKQADAPGYFPVGRGHEVGHTGSPANVCLICFPDGCRDLIPCEDSGTLCIQACSPSFHGEKSFVCKDRTWRMFTDACTNLDVQSLFQVVSEGHVAGGRFPFVGPGKPAHGKPGDGAKYFGADDSGRSNCQADFSCIVPEILSSPAIPGNIADIVELLQKISLMLLEDVNRGKMQSFSKIANHILNSSVISNWAFVKDKNASSTLLDSVNLFAGKLLLRNGSENIQERFISTKGFSIHQNASGKSFDFSMELNQTNTVSGHVVIPEEELQKLPKTSKAISIAFPTLGAIMEASHLDPVSVNGMVLSVSLPEELQHILLTFEKVNKLENVGAQCVGWHSTERRWDHKACKMKSNNISSVVCMCKHRRRTFRSFSILMSPTLLRNAVLDYITCVGLGLSIFSLILCLVIETTVWHHVTRTEITYMRHFCLVNIAMSLLIADILFIVAAVVHNAALNYRLCVAATFFLHLFYLALFFWMFTLGLLILYGLLLVFFKITRSVFIVTAFLIGYGCPLVIAVLTVIITEPKNGYLRSGACWLNWYETKALLAFAVPALSIVAVNLAVVVVVVVKTPRPSIGESCKSHDLSNMIRISKNVALLTPLLGLTWGFGLATVVDSHSLAFHVTFALLNAFQGFFILLFGTLLDRKVLGAFPGMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SZ07</accession>
    <name>A0A8C2SZ07_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dynactin subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">DCTN2</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynactin subunit 2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SZ07"/>
    <dbReference type="Ensembl" id="ENSCJPT00005007690.1">
        <property type="protein sequence ID" value="ENSCJPP00005004623.1"/>
        <property type="gene ID" value="ENSCJPG00005004546.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000003427"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome LGE22C19W28_E50C23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030426">
        <property type="term" value="C:growth cone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031982">
        <property type="term" value="C:vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030507">
        <property type="term" value="F:spectrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032402">
        <property type="term" value="P:melanosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007080">
        <property type="term" value="P:mitotic metaphase chromosome alignment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071539">
        <property type="term" value="P:protein localization to centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028133">
        <property type="entry name" value="Dynamitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15346">
        <property type="entry name" value="DYNACTIN SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04912">
        <property type="entry name" value="Dynamitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0243">Dynein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005004623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="437" mass="48418" checksum="33A02457B23282AF" modified="2022-01-19" version="1">MGNYCGALGAVGRSGGGSWGRWPWRRPGTSSTLPQARNEPDVYETSDLPEDDQAEFEAEELTSTSVEHLIINPNAAFEKFKDKRLGTDGVDFSDRISKSRTTGYESGEYEILGEGLGAKETPQQRYQRLQHEVQELMRDVEQIQSAMKESAAEEELTPMALARQLEGLKQQLVSCHLQKLLGPSATIDFADPEGALAKRLQQQLEVAKCKKAAPAKSPPKAPAPPTDTLTFELFWRPEQDQFSQAAKVAELEKRLAQLEAMVRCEPDSQETVQILQAKVNILDAAVLDQVEARLQSVLGKVNEIAKHKAIVQDADTQSKIHQVYEMMQRWDHMASSLPDVVQRLLTLRDLHEQASRFVQVLVHLDTTQQEVAATLKDNTVLLAEVGPGGVGVGAVPVLPPLLTPPPHTQVQKTMKENLAVVEDNFAEVEARIKRLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SZC4</accession>
    <name>A0A8C2SZC4_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">PAN2-PAN3 deadenylation complex catalytic subunit PAN2</fullName>
            <ecNumber evidence="13">3.1.13.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Inactive ubiquitin carboxyl-terminal hydrolase 52</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">PAB1P-dependent poly(A)-specific ribonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Poly(A)-nuclease deadenylation complex subunit 2</fullName>
            <shortName evidence="13">PAN deadenylation complex subunit 2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">PAN2</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenylation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. Also acts as an important regulator of the HIF1A-mediated hypoxic response. Required for HIF1A mRNA stability independent of poly(A) tail length regulation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="13">Binds 2 metal cations per subunit in the catalytic exonuclease domain.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="13">Positively regulated by the regulatory subunit PAN3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Forms a heterotrimer with an asymmetric homodimer of the regulatory subunit PAN3 to form the poly(A)-nuclease (PAN) deadenylation complex. Interacts with PAN3 isoform 1/Pan3L and isoform 3/Pan3S. Interacts with ZFP36.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
            <location evidence="13">P-body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Nucleus</location>
        </subcellularLocation>
        <text evidence="13">Shuttles between nucleus and cytoplasm.</text>
    </comment>
    <comment type="domain">
        <text evidence="13">Contains a pseudo-UCH domain. This ubiquitin C-terminal hydrolase (UCH)-like or ubiquitin specific protease (USP)-like domain is predicted to be catalytically inactive because it lacks the active site catalytic triad characteristic of thiol proteases, with residues at the equivalent structural positions that are incompatible with catalysis, and it cannot bind ubiquitin. It functions as a structural scaffold for intra- and intermolecular interactions in the complex.</text>
    </comment>
    <comment type="domain">
        <text evidence="13">The linker, or PAN3 interaction domain (PID), between the WD40 repeats and the pseudo-UCH domain mediates interaction with PAN3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the peptidase C19 family. PAN2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="13"/>
    <dbReference type="Ensembl" id="ENSCJPT00005007863.1">
        <property type="protein sequence ID" value="ENSCJPP00005004767.1"/>
        <property type="gene ID" value="ENSCJPG00005004634.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000013978"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome LGE22C19W28_E50C23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031251">
        <property type="term" value="C:PAN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010606">
        <property type="term" value="P:positive regulation of cytoplasmic mRNA processing body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06143">
        <property type="entry name" value="PAN2_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02672">
        <property type="entry name" value="Peptidase_C19P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000059">
        <property type="entry name" value="PAN2-PAN3 deadenylation complex catalytic subunit PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000011">
        <property type="entry name" value="PAN2-PAN3 deadenylation complex catalytic subunit PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000017">
        <property type="entry name" value="PAN2-PAN3 deadenylation complex catalytic subunit PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03182">
        <property type="entry name" value="PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021852">
        <property type="entry name" value="DUF3456"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030843">
        <property type="entry name" value="PAN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050785">
        <property type="entry name" value="PAN2-PAN3_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048841">
        <property type="entry name" value="PAN2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028881">
        <property type="entry name" value="PAN2_UCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15728">
        <property type="entry name" value="DEADENYLATION COMPLEX CATALYTIC SUBUNIT PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15728:SF0">
        <property type="entry name" value="PAN2-PAN3 DEADENYLATION COMPLEX CATALYTIC SUBUNIT PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11938">
        <property type="entry name" value="DUF3456"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20770">
        <property type="entry name" value="PAN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13423">
        <property type="entry name" value="UCH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="8 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 13" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 13" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="USP" evidence="14">
        <location>
            <begin position="517"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="973"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="975"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="1082"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="1134"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00056862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00062332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005004767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1301" mass="146868" checksum="7000B545FA26F13F" modified="2022-01-19" version="1">MNFEGLDPSLAEYAPTLHPALDPVLDPHLNPNLLQNVELDPDGVPLEGIAVPESVHIVEGMYSELHTAVSEVGVPVSVSHFDLHEEMLWVGNHGGHATSFFGPTLERYSSFQVNSSDDIRQIQSLENGVLFLTKTNLKCMSRGGLIIFDYLMDEAEDMHSLLLTDSSTLLVGGLQNHVIEIDLNTVQETQKFTVEVPGITIMRQSNRFFFCGHTSGKVSLRDLRTFVVEHEFDAYSGSLSDFDVHGNLLVTCGFSSRMNGLACDRFLKVYDLRMMRATTPLQVHIDPFFLRFIPTYTSRLAIISQTGQCQFCEPTGLANPADIFHVNTVGPLIMTFDVSASKQALAFGDSEGCVHLWADSPEVTFNTYSRETDFALPCIVDTLPHLDWNQDLVPLSLIPVPLTSETLLSDWPAANSAPAPRRAPPVDPEILRTMKKVGFIGYAPNPRTKLRNQIPYRLKEADNEFDSFSQVPESPIGREEEPHLYMVAKKYRKVTIKYSKLGLEDFDFKHYNKTLFAGLEPHIPNAYCNCMIQVLYFLEPVRCLVQNHLCQKEFCLGCELGLLFHMLDLSRGDPCQGSNFLRAFRTIPEASALGLILADSDEATGKVNLGRLIQSWNRFILTQLHQETQEQEGPQAYRGAGSSTFGSSGDSVIGQLFSCEVENCSMCRCGKETVRVSSTLLFTLSYPESTEKPVKDYEFAQILKRSICLEQNTQAWCENCEKYQPTVQTRNIRCLPDVLVINCEVNSSKEADFWKTQAEYAFQRALMKRGGFEITKGKEMSLGDWKELGNPEVGHSYPSVEELKNIWIPHAIKMRLTKNKELDVCNWSESDELSPNDDPESVYVYDLMATVVHILDSRTGGSLVGHIKVGETYHQRKEGVTHQQWYLFNDFLIEPVDKCEAVQFDMSWKVPAILYYARRNLNSKYNLIIKNPIEASVLLAEASLARKQRKCHATFIPLMLSEMPQAGDLVGLDAEFVTLNEEEAELRSDGTKSTIKPSQMSVARITCVRGQGPNEGVPFIDDYISTQEQVVDYLTQYSGIKPGDLDAKISSKHLTTLKSTYLKLRFLIDVGVKFVGHGLQKDFRVINLMVPKDQVIDTVYLFHIPRKRMISLRFLAWYFLDLKIQGETHDSIEDARTALQLYRKYLELSNDPDNFRKVLKALYEKGRKLDWKVPEPDSQSSPKPCRALVDELEWEIAQVDPRKTIQMGSFRINPDGSQSVVEVPYARSEAHLTELLERVCEKMKEYGEKVDPATHRKSYERIVSHDGTKMDLNGLKNRPGDVAASLNLRCVGGGGSWWDWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T066</accession>
    <name>A0A8C2T066_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Vacuolar protein sorting 13 homolog D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">VPS13D</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS13 family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSCJPT00005008392.1">
        <property type="protein sequence ID" value="ENSCJPP00005005119.1"/>
        <property type="gene ID" value="ENSCJPG00005001653.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183083"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901526">
        <property type="term" value="P:positive regulation of mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23453">
        <property type="entry name" value="beta-trefoil_Ricin_VPS13D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14306">
        <property type="entry name" value="UBA_VP13D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000107">
        <property type="entry name" value="Vacuolar protein sorting 13 homolog D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041969">
        <property type="entry name" value="VP13D_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026847">
        <property type="entry name" value="VPS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056747">
        <property type="entry name" value="VPS13-like_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026854">
        <property type="entry name" value="VPS13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009543">
        <property type="entry name" value="VPS13_VAB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166:SF141">
        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25033">
        <property type="entry name" value="VPS13_M"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12624">
        <property type="entry name" value="VPS13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25036">
        <property type="entry name" value="VPS13_VAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="UBA" evidence="5">
        <location>
            <begin position="2630"/>
            <end position="2673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="762"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1442"/>
            <end position="1463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1745"/>
            <end position="1771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2104"/>
            <end position="2130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2594"/>
            <end position="2627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="766"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1444"/>
            <end position="1463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="2594"/>
            <end position="2608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="2609"/>
            <end position="2621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005005119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="4366" mass="488486" checksum="DF8A579B86D7E993" modified="2022-01-19" version="1">[encoded data, 4366 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T2N0</accession>
    <name>A0A8C2T2N0_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">F-box protein 44</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FBXO44</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T2N0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005011392.1">
        <property type="protein sequence ID" value="ENSCJPP00005007340.1"/>
        <property type="gene ID" value="ENSCJPG00005006764.1"/>
    </dbReference>
    <dbReference type="KEGG" id="cjo:107323527"/>
    <dbReference type="GeneTree" id="ENSGT00940000159408"/>
    <dbReference type="OrthoDB" id="1107553at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22168">
        <property type="entry name" value="F-box_FBXO6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000012">
        <property type="entry name" value="F-box only protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.50:FF:000002">
        <property type="entry name" value="F-box only protein 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007397">
        <property type="entry name" value="F-box-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039752">
        <property type="entry name" value="F-box_only"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12125:SF12">
        <property type="entry name" value="F-BOX ONLY PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12125">
        <property type="entry name" value="F-BOX ONLY PROTEIN 6-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04300">
        <property type="entry name" value="FBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01198">
        <property type="entry name" value="FBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51114">
        <property type="entry name" value="FBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="FBA" evidence="3">
        <location>
            <begin position="69"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005007340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="260" mass="30586" checksum="17795EDB30064A72" modified="2022-01-19" version="1">MATISDLPEDVLVELLSLLPAQDLLRACRLVCSQWRDVVDLTTLWKRKCQREGFYVQSLDRSIADWKVFYLLCKLKRNLIKNPRAEESFNHWQLDQNEGDRWKIEDLPGPLGKELPDSEVRKYFVTSFGPCFKSQLITLKKEGYWNELMDEKRPEIVVKDWYAARFDCGCRYELRVKLLSENYIVLQEFCPEPVVIEQWSDATWREMSHTFSNYPPGVRYIWFQHGGQDTQFWAGWYGIRVTNSSITIGPQTLKANEDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T5A0</accession>
    <name>A0A8C2T5A0_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="22">FAT atypical cadherin 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">FAT1</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
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        <source>
            <dbReference type="PROSITE" id="PS50025"/>
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        <source>
            <dbReference type="PROSITE" id="PS50026"/>
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        <source>
            <dbReference type="PROSITE" id="PS50268"/>
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        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005007849.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
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    <sequence length="4645" mass="514391" checksum="A65F64E0735F5019" modified="2022-01-19" version="1">[encoded data, 4645 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T5N6</accession>
    <name>A0A8C2T5N6_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Riboflavin kinase</fullName>
            <ecNumber evidence="3">2.7.1.26</ecNumber>
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        <alternativeName>
            <fullName evidence="16">ATP:riboflavin 5'-phosphotransferase</fullName>
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        <alternativeName>
            <fullName evidence="13">Flavokinase</fullName>
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        <name evidence="18" type="primary">RFK</name>
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    <organism evidence="18 19">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
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        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
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    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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    <comment type="function">
        <text evidence="15">Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin-mononucleotide (FMN), hence rate-limiting enzyme in the synthesis of FAD. Essential for TNF-induced reactive oxygen species (ROS) production. Through its interaction with both TNFRSF1A and CYBA, physically and functionally couples TNFRSF1A to NADPH oxidase. TNF-activation of RFK may enhance the incorporation of FAD in NADPH oxidase, a critical step for the assembly and activation of NADPH oxidase.</text>
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        <reaction evidence="14">
            <text>riboflavin + ATP = FMN + ADP + H(+)</text>
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            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
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        <cofactor evidence="1">
            <name>Zn(2+)</name>
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        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (ATP route): step 1/1.</text>
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        <property type="nucleotide sequence ID" value="XM_015849172.2"/>
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        <property type="protein sequence ID" value="ENSCJPP00005008886.1"/>
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        <property type="reaction ID" value="UER00406"/>
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        <property type="component" value="Chromosome Z"/>
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        <property type="term" value="C:mitochondrion"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0008531">
        <property type="term" value="F:riboflavin kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0009398">
        <property type="term" value="P:FMN biosynthetic process"/>
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        <property type="project" value="UniProtKB-UniPathway"/>
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        <property type="term" value="P:riboflavin biosynthetic process"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Riboflavin kinase, putative"/>
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        <property type="entry name" value="Riboflavin kinase-like"/>
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        <property type="entry name" value="Riboflavin_kinase"/>
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        <property type="entry name" value="Riboflavin_kinase_bac/euk"/>
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    <dbReference type="InterPro" id="IPR023465">
        <property type="entry name" value="Riboflavin_kinase_dom_sf"/>
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    <dbReference type="PANTHER" id="PTHR22749:SF6">
        <property type="entry name" value="RIBOFLAVIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RIBOFLAVIN KINASE/FMN ADENYLYLTRANSFERASE"/>
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        <property type="entry name" value="Flavokinase"/>
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    </dbReference>
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        <property type="entry name" value="Flavokinase"/>
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        <property type="entry name" value="Riboflavin kinase-like"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Riboflavin kinase" evidence="17">
        <location>
            <begin position="9"/>
            <end position="139"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00054097"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00077632"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005008886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="161" mass="18169" checksum="76F527406DA60168" modified="2022-01-19" version="1">MRGRCAAAMRHLPYFCRGEVVKGFGRGSSQLGVPTANFSEQVVESFPSDIPTGIYYGWASVGNGDVHKMVLSIGWNPFYKNIKKSVETHIINTFKEDFYGEILSIAIVGYIRSEKNFNSLETLISAIQEDIEEAKRQLDLPEHLKLKDNFFHLPEGKIVNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T5U5</accession>
    <name>A0A8C2T5U5_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transmembrane protein 106C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">TMEM106C</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM106 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015705861.1">
        <property type="nucleotide sequence ID" value="XM_015850375.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T5U5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005013451.1">
        <property type="protein sequence ID" value="ENSCJPP00005008944.1"/>
        <property type="gene ID" value="ENSCJPG00005007927.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005013453.1">
        <property type="protein sequence ID" value="ENSCJPP00005008946.1"/>
        <property type="gene ID" value="ENSCJPG00005007927.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107306960"/>
    <dbReference type="KEGG" id="cjo:107306960"/>
    <dbReference type="CTD" id="79022"/>
    <dbReference type="GeneTree" id="ENSGT00940000161281"/>
    <dbReference type="OrthoDB" id="508875at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009790">
        <property type="entry name" value="TMEM106"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048509">
        <property type="entry name" value="TMEM106_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048511">
        <property type="entry name" value="TMEM106_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28556">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 106B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28556:SF5">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 106C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07092">
        <property type="entry name" value="TMEM106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21002">
        <property type="entry name" value="TMEM106_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Transmembrane protein 106 N-terminal" evidence="9">
        <location>
            <begin position="28"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Transmembrane protein 106 C-terminal" evidence="8">
        <location>
            <begin position="113"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005008944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="272" mass="30056" checksum="3B81241FD7A253CA" modified="2022-01-19" version="1">MGSALSLSATNPASRQRRKADGAADGDDDLLDSQDRNEDIAKFPYVEFTGQDSITCPTCQGTGCIPTEQVNELVALIPYSDQRLRPQRTKLYVLLSVLLCLLISGLVVFFLFPHSVLVDDGGIKVVQVWFDRKNSVVLLAITATLRIRNSNFYSVTVDSLTSQVQYMNTVVGSQQITNISNIQPLSDKLVNFTVKAEMGGPFSYVYFFCTFPKVNVHNIVIFMRTSVKLSYMGRRTQSSVETYHYIDCSTNNTADPPPLPAPSLHGVALSKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T6T2</accession>
    <name>A0A8C2T6T2_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box protein 28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FBXO28</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015712651.1">
        <property type="nucleotide sequence ID" value="XM_015857165.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T6T2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005011994.1">
        <property type="protein sequence ID" value="ENSCJPP00005007831.1"/>
        <property type="gene ID" value="ENSCJPG00005007111.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107311008"/>
    <dbReference type="KEGG" id="cjo:107311008"/>
    <dbReference type="CTD" id="23219"/>
    <dbReference type="GeneTree" id="ENSGT00390000002970"/>
    <dbReference type="OrthoDB" id="5860767at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22100">
        <property type="entry name" value="F-box_FBXO28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039719">
        <property type="entry name" value="FBXO28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13252">
        <property type="entry name" value="F-BOX ONLY PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13252:SF9">
        <property type="entry name" value="F-BOX ONLY PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="43"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005007831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="350" mass="39307" checksum="86761CE32E29AA59" modified="2022-01-19" version="1">MAAAEERLLSEGEGGAPGSARLSPPPLSQSPEAPAPLEQPPQSNTLMGLPIVAIESILSFLSYDETSQLRLVCKRMDLVCQRMLNQGFLKVERYHNLCQKQVKAQLPRRESERRNHSLARHADILAAVETRLSLLNMTFMKYVDSNLCCFIPGKVIDEIYRVLRYVNSTRAPQRAHEVLQELRDISSMAMEYFDEKIVPILKRKLPGSDVSGRLIGAAPVPGPSAALTTMQLFSKQNPSRQEVTKLQQQVKANGAGVTVLKREISELRTKVQEQQKQLQDQDQKLLEQTQIIGEQNARLAELERKLREVMESAVGSSSGTGSNEQSPRKRRKAVESTDCPRKSKRLRNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T6V9</accession>
    <name>A0A8C2T6V9_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Potassium voltage-gated channel subfamily E member 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">KCNE1</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="19">Ancillary protein that functions as a regulatory subunit of the voltage-gated potassium (Kv) channel complex composed of pore-forming and potassium-conducting alpha subunits and of regulatory beta subunits. KCNE1 beta subunit modulates the gating kinetics and enhances stability of the channel complex. Alters the gating of the delayed rectifier Kv channel containing KCNB1 alpha subunit. Associates with KCNQ1/KVLQT1 alpha subunit to form the slowly activating delayed rectifier cardiac potassium (IKs) channel responsible for ventricular muscle action potential repolarization. The outward current reaches its steady state only after 50 seconds. Assembly with KCNH2/HERG alpha subunit Kv channel may regulate the rapidly activating component of the delayed rectifying potassium current (IKr) in heart.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane raft</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the potassium channel KCNE family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015737535.1">
        <property type="nucleotide sequence ID" value="XM_015882049.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T6V9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005012712.1">
        <property type="protein sequence ID" value="ENSCJPP00005008369.1"/>
        <property type="gene ID" value="ENSCJPG00005007499.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107323195"/>
    <dbReference type="KEGG" id="cjo:107323195"/>
    <dbReference type="CTD" id="3753"/>
    <dbReference type="GeneTree" id="ENSGT00940000154497"/>
    <dbReference type="OrthoDB" id="8772344at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005251">
        <property type="term" value="F:delayed rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015459">
        <property type="term" value="F:potassium channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031433">
        <property type="term" value="F:telethonin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044325">
        <property type="term" value="F:transmembrane transporter binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902282">
        <property type="term" value="F:voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071320">
        <property type="term" value="P:cellular response to cAMP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002070">
        <property type="term" value="P:epithelial cell maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901381">
        <property type="term" value="P:positive regulation of potassium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097623">
        <property type="term" value="P:potassium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0086091">
        <property type="term" value="P:regulation of heart rate by cardiac conduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060307">
        <property type="term" value="P:regulation of ventricular cardiac muscle cell membrane repolarization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033363">
        <property type="term" value="P:secretory granule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021750">
        <property type="term" value="P:vestibular nucleus development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000369">
        <property type="entry name" value="K_chnl_KCNE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005424">
        <property type="entry name" value="KCNE1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15282:SF10">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY E MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15282">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY E MEMBER 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02060">
        <property type="entry name" value="ISK_Channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01604">
        <property type="entry name" value="KCNE1CHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00168">
        <property type="entry name" value="KCNECHANNEL"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="17" id="KW-0407">Ion channel</keyword>
    <keyword evidence="14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="15 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-0630">Potassium</keyword>
    <keyword evidence="10" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="7" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="11" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00035196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00045479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005008369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="126" mass="14183" checksum="70108EBD23DD0324" modified="2022-01-19" version="1">MLVLSNDTALSILLSKLLQDHLEQTNSTAPSTAGSTGGSLEIIYLLMMVGLFGFFTVGVMVTNIRARRLDDSHNPYNTYIATDIWHKKDQEYFQAKLIENYKLCCVFENQLAVEQPSIHIPEEKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T6Z1</accession>
    <name>A0A8C2T6Z1_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">SH3 domain containing GRB2 like 2, endophilin A1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">SH3GL2</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Early endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the endophilin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T6Z1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005012955.1">
        <property type="protein sequence ID" value="ENSCJPP00005008557.1"/>
        <property type="gene ID" value="ENSCJPG00005007638.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160529"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome Z"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098684">
        <property type="term" value="C:photoreceptor ribbon synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098794">
        <property type="term" value="C:postsynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099523">
        <property type="term" value="C:presynaptic cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990416">
        <property type="term" value="P:cellular response to brain-derived neurotrophic factor stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097484">
        <property type="term" value="P:dendrite extension"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905604">
        <property type="term" value="P:negative regulation of blood-brain barrier permeability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042059">
        <property type="term" value="P:negative regulation of epidermal growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098974">
        <property type="term" value="P:postsynaptic actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002090">
        <property type="term" value="P:regulation of receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016191">
        <property type="term" value="P:synaptic vesicle uncoating"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07613">
        <property type="entry name" value="BAR_Endophilin_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11803">
        <property type="entry name" value="SH3_Endophilin_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000053">
        <property type="entry name" value="endophilin-A1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000021">
        <property type="entry name" value="Endophilin-A2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035824">
        <property type="entry name" value="Endophilin_A_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050384">
        <property type="entry name" value="Endophilin_SH3RF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167:SF50">
        <property type="entry name" value="ENDOPHILIN-A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="10" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="BAR" evidence="15">
        <location>
            <begin position="28"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="14">
        <location>
            <begin position="301"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="253"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="253"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005008557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="363" mass="41097" checksum="90DEAD49FA80EA12" modified="2022-01-19" version="1">MCLDNTTERLLCPQSALSHAGNKYRKVSEKVGGAEGTKLDDDFKEMERKVDVTSRAVMEIMAKTIEYLQPNPASRAKLSMINTMSKIRGQEKGPGYPQAEALLADAMLKFGRELGEECNFGPALADVGEAMKELSEVKDSLDMEVKQNFIDPLQNLHDKDLREIQHHLKKMEGRRLDFDYKKKRQGKLPDEELRQALEKFDESKEIAESSMFNLLEMDIEQVSQLSALVQAQLEYHKQATQILQRVTSKLEDRIKEASSQPKREYQPKPRMSLDFTTGGDNTQHNGGISHATTPKPAGAHMDQPCCRALYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHGQSGFFPINYVDILVPLPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T755</accession>
    <name>A0A8C2T755_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">NYAP2</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015726912.1">
        <property type="nucleotide sequence ID" value="XM_015871426.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015726913.1">
        <property type="nucleotide sequence ID" value="XM_015871427.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015726915.1">
        <property type="nucleotide sequence ID" value="XM_015871429.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T755"/>
    <dbReference type="Ensembl" id="ENSCJPT00005013708.1">
        <property type="protein sequence ID" value="ENSCJPP00005009153.1"/>
        <property type="gene ID" value="ENSCJPG00005008087.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107318061"/>
    <dbReference type="KEGG" id="cjo:107318061"/>
    <dbReference type="CTD" id="57624"/>
    <dbReference type="GeneTree" id="ENSGT00890000139453"/>
    <dbReference type="OrthoDB" id="9832999at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048812">
        <property type="term" value="P:neuron projection morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043491">
        <property type="term" value="P:phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026722">
        <property type="entry name" value="NYAP1/NYAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029353">
        <property type="entry name" value="NYAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039482">
        <property type="entry name" value="NYAP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22633:SF1">
        <property type="entry name" value="NEURONAL TYROSINE-PHOSPHORYLATED PHOSPHOINOSITIDE-3-KINASE ADAPTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22633">
        <property type="entry name" value="NEURONAL TYROSINE-PHOSPHORYLATED PHOSPHOINOSITIDE-3-KINASE ADAPTER 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15452">
        <property type="entry name" value="NYAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15439">
        <property type="entry name" value="NYAP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter N-terminal" evidence="3">
        <location>
            <begin position="51"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter C-terminal" evidence="4">
        <location>
            <begin position="461"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="114"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="371"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="675"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="192"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="396"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="453"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="484"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="528"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="589"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005009153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="715" mass="78358" checksum="6A1CE00FD6BE225F" modified="2022-01-19" version="1">MMSSNKEEVTLGAFLQYIEDMGMKAYDGLVIQNASDIARENDRMRNETNLAYLKEKSEKRRKQEEAIKRIGGEVVRGNEGSYVGKHFRMGFMTMPAPQDRLPHPCSSGFAVRSQSLHSVGGTDDESSSSRKQPPPKPKRDPNTKLSTSSETVNTGTTSKSGKLPDRTEVSAKPRPHSDEYTKKIPPPKPKRNPNTQLSTSFDETYIKKHGPMKTPLTRDASLSQVSSPAPDTEEEEPVYIEMVGNILRDFKKDEDDQSEAVYEEMKYPIFDDVGQDSKCQCEYDHHTCSSQCATPTVPDLDFTKTSVPSTPKGLLCDIPPPFPNLLSHRPPLLVFPPAPVQCSPNSDESPLTPLEVTKLPVLENVSYIKQQAGASPSSLPPHTPGHQKLEKEQMVSHGTSTSGHTSSPPHPSTLYRTQSPHGYPKSHSASPSPVSMGRSLTPLSLKRPPPYDSVHSGSLSRSSPSVPHSTARNTLQEGGKMVNVSVSTYGSSSQSSSRSRTPTSPLEELTSLFTSGRSLLRKSSSGRRSKEPAEKPLDELKIRSHSTEPLPKLENKERGGHHGTASSREPGKAQEWDGTPGPPMVSSRLGRSSVSPTMLAGSNSSEPKASCRLGRSASTSGVPPPSVTPLRQASDLQPSQVTCMQWLQGDHTMLDMIEKKRCLCKEIKARQKSEKGLCKQDSMPILPSWKKNTGTKKYSPPPYSKQQTVFWDTAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T7T3</accession>
    <name>A0A8C2T7T3_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T7T3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005012559.1">
        <property type="protein sequence ID" value="ENSCJPP00005008251.1"/>
        <property type="gene ID" value="ENSCJPG00005007415.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01040000244513"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005008251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="108" mass="11200" checksum="4C718B051A860647" modified="2022-01-19" version="1">SALPRGSGDPRCPSSLLEKRRRVRIDESLNQLKTLILPLVCKAVSAAARPCVPSLPSLSPPRPSPLPGARCPPPPLIELPLLQAGEGGHPGDDRAVPDGGSSCSLGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T878</accession>
    <name>A0A8C2T878_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">PSMA4</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T878"/>
    <dbReference type="Ensembl" id="ENSCJPT00005013641.1">
        <property type="protein sequence ID" value="ENSCJPP00005009098.1"/>
        <property type="gene ID" value="ENSCJPG00005008051.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00550000074827"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03752">
        <property type="entry name" value="proteasome_alpha_type_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000022">
        <property type="entry name" value="Proteasome subunit alpha type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4 6 7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="9">
        <location>
            <begin position="5"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005009098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="261" mass="29495" checksum="2D0CDFF019AD7863" modified="2022-01-19" version="1">QSRRYDSRTTIFSPEGRLYQVEYAMEAIGHAGTCLGILANDGVLLAAERRNIHKLLDEVFFSEKIYKLNEDMACSVAGITSDANVLTNELRLIAQRYLLQYQEPIPCEQLVTALCDIKQAYTQFGGKRPFGVSLLYIGWDKHYGFQLYQSDPSGNYGGWKATCIGNNSAAAVSMLKQDYKEGEMTLKTALALAIKVLNKTMDVSKLSAEKVEIATLTRENGKTVIRVLKQKEVEQLIKQHEEEEAKAEREKKEKEQKEKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T8C5</accession>
    <name>A0A8C2T8C5_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Claudin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC107323391</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell junction</location>
            <location evidence="8">Tight junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the claudin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T8C5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005011949.1">
        <property type="protein sequence ID" value="ENSCJPP00005007790.1"/>
        <property type="gene ID" value="ENSCJPG00005007084.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000165186"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006187">
        <property type="entry name" value="Claudin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003927">
        <property type="entry name" value="Claudin16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017974">
        <property type="entry name" value="Claudin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004031">
        <property type="entry name" value="PMP22/EMP/MP20/Claudin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12002">
        <property type="entry name" value="CLAUDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00822">
        <property type="entry name" value="PMP22_Claudin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01077">
        <property type="entry name" value="CLAUDIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01447">
        <property type="entry name" value="CLAUDIN16"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01346">
        <property type="entry name" value="CLAUDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0965">Cell junction</keyword>
    <keyword evidence="3 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="2 8" id="KW-0796">Tight junction</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034194299" description="Claudin" evidence="9">
        <location>
            <begin position="29"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU060637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005007790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="246" mass="26954" checksum="860D00E2EDC2DF57" modified="2022-01-19" version="1">MSAILQMTAFGLTLLSALFLLLATCTDCWMVNADDSLEVSHKCRGLWRECVTNMQDGVRTCDQYDSILADHPVKIVVARTLLITADLLVGLAWATLLLGLDCIKFLKEEPRVKLKLCYGAGVILGIGSILGLVGSVWYAVDVYVERAMLVSHNLFLGVHYDFGWSCWLGMAGSTGCFMASVLLTCCLRAHTGQSVLSCRDIPGWTTRRVQIQGRSHLIKAPSPTWDSSAMCHAVREDAEALRNGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T8R3</accession>
    <name>A0A8C2T8R3_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zinc finger protein 644</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ZNF644</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_032301969.1">
        <property type="nucleotide sequence ID" value="XM_032446078.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032301970.1">
        <property type="nucleotide sequence ID" value="XM_032446079.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032301971.1">
        <property type="nucleotide sequence ID" value="XM_032446080.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032301972.1">
        <property type="nucleotide sequence ID" value="XM_032446081.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032301973.1">
        <property type="nucleotide sequence ID" value="XM_032446082.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032301975.1">
        <property type="nucleotide sequence ID" value="XM_032446084.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032301976.1">
        <property type="nucleotide sequence ID" value="XM_032446085.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032301977.1">
        <property type="nucleotide sequence ID" value="XM_032446086.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032301978.1">
        <property type="nucleotide sequence ID" value="XM_032446087.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032301979.1">
        <property type="nucleotide sequence ID" value="XM_032446088.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032301980.1">
        <property type="nucleotide sequence ID" value="XM_032446089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T8R3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005013954.1">
        <property type="protein sequence ID" value="ENSCJPP00005009338.1"/>
        <property type="gene ID" value="ENSCJPG00005008211.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107317501"/>
    <dbReference type="CTD" id="84146"/>
    <dbReference type="GeneTree" id="ENSGT00940000158258"/>
    <dbReference type="OrthoDB" id="8669871at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001222">
        <property type="term" value="F:transcription corepressor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000409">
        <property type="entry name" value="zinc finger protein 644 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051643">
        <property type="entry name" value="Transcr_Reg_ZincFinger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055125">
        <property type="entry name" value="Wiz_C_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24396">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24396:SF25">
        <property type="entry name" value="ZINC FINGER PROTEIN 644"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23015">
        <property type="entry name" value="zf-WIZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="387"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="425"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="868"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="1066"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="662"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="444"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005009338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1198" mass="134646" checksum="CB76F81D63905934" modified="2022-01-19" version="1">MDDLVINTEVTGAKEEEEEILCDFVSEEEGGIPESQESDALFQKNNTLTLPEELSRDRSEKALSGGQTSLFIHTGAPTVSSENFILSRGTAVNGPVSHSTSTKTSIMNKGSVSLTTGQPVGHHTDSCSTLTVVHDLQLPAKSTTENSNQHQVLFLLPDVAHAKNMTHSIKNVPTSASVGCDSQKSVGNSVDSTLVGQVEVCEDDKNLLVKDDCVDALTGISSGTGGFRSGCEPSWDPQKEFIQFLMTNEETIEKSPIHCKVGLEKKRKRKMDVSKITRYTEDCFGDTTYIPSKSKLLTVDFLEQNEELQIVEPQKYSLSKVKPESTDEELEAVDAIQQLIYSPTGSCAEDASPVHTSTFLSNTLKNKCEQNDSESPSTFSTDEPSFYPCTKCNVNFREKKHLHRHMMYHLDGNSHFRHLNVPRPYACRECGRTFRDRNSLLKHMIIHQERRQKLMEEIRELKELQDEGRSARLQCPQCVFGTNCPKTFVQHAKTHEKDKRYYCCEECNFMAVTENELECHRGIAHGAVVKCSVIGSDMSQRKSQKKASMKDPYLGSSKKSSTYMCKMCPFTTSARSILKKHMEYLHPASCIDPFGSHLRLEKRKGSIIEESLDFGSRTKQLIKQSSTFPKNSVLKQDVKRSFGSTSQSGNFGKLHKRPYRIQKARKSVSQSSRLNSAEKKDSYETEDESSWDNAELCDYTTRSVEDESYSDINQEHVSLFPIFKGKMEDHEAGDKSSLSYEQNDGFYFEYYEDAESSNFLHDLHDAQNLENVGSALPKHNSVFHWTDLSLEKKSCPYCPATFETGVGLSNHVRGHLHRAGLSYEARHVVSPEQIATSDKMQHFKRTGTGTPVKRVRKAIEKSETSSEHTCQLCGGWFDTKIGLSNHVRGHLKRLGKTKWDAHKSPICVLNEMMQNEEKYEKILKALNSRRVIPRPFVAQKFASNDDFLSQNVLPLEAYHNGLKTEDISVSASEEEGLSFLNECDETKAVLHNEKKNQSLTLIELLKNKRLGEERSPGISSQKIHNQTARKRFVQKCVLPLNEDSPLMYQPQKMDLTMQSGMPVKLRTCVHCNTTFTSAVSLSNHLRAYARKKSAGLLTGTALDCKQKKSRSRSGSKKKMMPLPHSADEVYILRCRFCGLVFRGPLSVQEDWIKHLQRHIVNANLPRTGAGMVEVTSLLKKPASITETSFSLLMAEAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T9W4</accession>
    <name>A0A8C2T9W4_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">UMP-CMP kinase 2, mitochondrial</fullName>
            <ecNumber evidence="16">2.7.4.14</ecNumber>
            <ecNumber evidence="3">2.7.4.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Nucleoside-diphosphate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">CMPK2</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>CMP + ATP = CDP + ADP</text>
            <dbReference type="Rhea" id="RHEA:11600"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.14"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>dCMP + ATP = dCDP + ADP</text>
            <dbReference type="Rhea" id="RHEA:25094"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57566"/>
            <dbReference type="ChEBI" id="CHEBI:58593"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.14"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>dTMP + ATP = dTDP + ADP</text>
            <dbReference type="Rhea" id="RHEA:13517"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58369"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thymidylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.14" evidence="16"/>
    <dbReference type="EC" id="2.7.4.9" evidence="3"/>
    <dbReference type="RefSeq" id="XP_015714875.1">
        <property type="nucleotide sequence ID" value="XM_015859389.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T9W4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005014646.1">
        <property type="protein sequence ID" value="ENSCJPP00005009842.1"/>
        <property type="gene ID" value="ENSCJPG00005008614.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107312186"/>
    <dbReference type="KEGG" id="cjo:107312186"/>
    <dbReference type="CTD" id="129607"/>
    <dbReference type="GeneTree" id="ENSGT00940000154030"/>
    <dbReference type="OrthoDB" id="425602at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:dTMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033862">
        <property type="term" value="F:UMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071222">
        <property type="term" value="P:cellular response to lipopolysaccharide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006227">
        <property type="term" value="P:dUDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001133">
        <property type="entry name" value="UMP-CMP kinase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00165">
        <property type="entry name" value="Thymidylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018094">
        <property type="entry name" value="Thymidylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014505">
        <property type="entry name" value="UMP-CMP_kinase_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10344">
        <property type="entry name" value="THYMIDYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10344:SF4">
        <property type="entry name" value="UMP-CMP KINASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019736">
        <property type="entry name" value="dTMP_TKRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Thymidylate kinase-like" evidence="19">
        <location>
            <begin position="62"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00051396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00066590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00070686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00076149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005009842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="253" mass="28126" checksum="09CEEA03780BF204" modified="2022-01-19" version="1">MLRSCTAGPPGSLRLALPAAAPAVRRRLRECAARIPEAGAVLDILEKCPERQKKGEFPVVVFEGLDATGKTTVTQSVKDALGAVLLRSPPACISQWRTIFDEEPTPIRRAFYAAGNYILASEIAKASTQAPVIVDRYWHSTAAYTIATETDGNIQNLPPDDDAVYKWPEDLLKPDLVLLLTVSPEERTRRLEGRGLERTKEEAELEANSLFRRRIEESYRRMVNPACQEVDASPSKEEVFKTVLQLIKNHCAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TAC8</accession>
    <name>A0A8C2TAC8_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endoplasmic reticulum protein 27</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ERP27</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TAC8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005014265.1">
        <property type="protein sequence ID" value="ENSCJPP00005009563.1"/>
        <property type="gene ID" value="ENSCJPG00005008388.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00930000151058"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02982">
        <property type="entry name" value="PDI_b'_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929:SF193">
        <property type="entry name" value="ENDOPLASMIC RETICULUM RESIDENT PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929">
        <property type="entry name" value="PROTEIN DISULFIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005009563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="179" mass="21139" checksum="AFDB8EC9D324DC84" modified="2022-01-19" version="1">CDRGIFACLQADKDRRDMDMDREEMDADKMSRFIRMNELRLVTEYNPMVITVGVMHSSLQLNLLLFTDKKSPEHLEQMRRYRAAAELFEGKILFILVDVNLKSNEQVMAYFRLKKSQLPALAIFHTPDEKNDVLPLDEVSIERVTDFCNAFLQKIWLLTEEEEAQGKHYCPLQQFEQRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TAF7</accession>
    <name>A0A8C2TAF7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Prostaglandin F2-alpha receptor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Prostanoid FP receptor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">PTGFR</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015725925.1">
        <property type="nucleotide sequence ID" value="XM_015870439.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015725926.1">
        <property type="nucleotide sequence ID" value="XM_015870440.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015725928.1">
        <property type="nucleotide sequence ID" value="XM_015870442.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TAF7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005014315.1">
        <property type="protein sequence ID" value="ENSCJPP00005009599.1"/>
        <property type="gene ID" value="ENSCJPG00005008414.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107317568"/>
    <dbReference type="KEGG" id="cjo:107317568"/>
    <dbReference type="CTD" id="5737"/>
    <dbReference type="GeneTree" id="ENSGT01030000234559"/>
    <dbReference type="OrthoDB" id="5959154at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 8"/>
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        <property type="entry name" value="7tm_1"/>
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        <property type="entry name" value="PROSTANOIDR"/>
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        <property type="entry name" value="PRSTNOIDFPR"/>
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        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
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    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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            <end position="50"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="13">
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            <begin position="62"/>
            <end position="90"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="102"/>
            <end position="129"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="198"/>
            <end position="226"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="246"/>
            <end position="271"/>
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    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="41"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00013486"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00030154"/>
        </source>
    </evidence>
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            <dbReference type="SAM" id="Phobius"/>
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        <source>
            <dbReference type="PROSITE" id="PS50262"/>
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    </evidence>
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            <dbReference type="Ensembl" id="ENSCJPP00005009599.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="364" mass="40985" checksum="A37F229FE647ED00" modified="2022-01-19" version="1">MNNSKSPGLAGFGILKNTTCHTEKKISVFFSIIFMTVGILSNSLAIAILMKAYQRFRQKSKASFLLLASGLVITDLFGHLINGAIAVFVYASDKDWIRFNQSNILCSVFGICMVFFGLCPLFLGSVMAVERCIGVTKPIFHSTKMTSKHVKMMLTMVCLFAVLIALLPILRFRAYQIQASRTWCFYKTEHVEDWEDRFYLLLFSCLGLLALAISFLCNAVTGITLLRVKFKSQQRQGRSHHFEMIIQLLAIMCVSCICWSPFLVSMARIGINASHSKENCETILFALRMATWNQILDPWVYILLRKAVLKNLYKITRGCCGMPIINLHMWELSSIKNSLKVAAISESPVSSKQINLQPLSSTAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TAW1</accession>
    <name>A0A8C2TAW1_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ubinuclein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">UBN2</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ubinuclein family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSCJPT00005015278.1">
        <property type="protein sequence ID" value="ENSCJPP00005010286.1"/>
        <property type="gene ID" value="ENSCJPG00005008989.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155858"/>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014840">
        <property type="entry name" value="HRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026947">
        <property type="entry name" value="UBN_middle_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21669">
        <property type="entry name" value="CAPZ-INTERACTING PROTEIN AND RELATED PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21669:SF10">
        <property type="entry name" value="UBINUCLEIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08729">
        <property type="entry name" value="HUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14075">
        <property type="entry name" value="UBN_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hpc2-related" evidence="4">
        <location>
            <begin position="172"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Ubinuclein middle" evidence="5">
        <location>
            <begin position="427"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="227"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
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            <begin position="310"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="551"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="745"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="778"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="852"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="959"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1003"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1291"/>
            <end position="1310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="49"/>
            <end position="65"/>
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        <location>
            <begin position="66"/>
            <end position="96"/>
        </location>
    </feature>
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        <location>
            <begin position="310"/>
            <end position="321"/>
        </location>
    </feature>
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        <location>
            <begin position="328"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="553"/>
            <end position="563"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <end position="1065"/>
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    </feature>
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            <begin position="1066"/>
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        </location>
    </feature>
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        <location>
            <begin position="1133"/>
            <end position="1148"/>
        </location>
    </feature>
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        <location>
            <begin position="1156"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1301"/>
            <end position="1310"/>
        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00009911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF14075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005010286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1310" mass="141132" checksum="22BC2401D8DB4988" modified="2022-01-19" version="1">MAEPRRVPFISLSPVRRREAESPALEREPGGREPEPPPAGREVPLPEPPPRESAARLEPPREPGRPEPPPQREPPRPEPPPPPRQGSRQEPPPPQEALPLRQTVRLEVVLKDPTEEGCVEFSYPELLLCREARKKSVHSEDPFNDEQRERHEVEALAKKFEAKYSGKPHKHRKDRLQDLIDIGYGYDETDPFIDNSEAYDELVPASLTTKYGGFYINTGTLQFRQASDSEDDDFAEDKKHRPPKVKSEDHGMKKRKRKDEGMEKEKKPRKMKVPKQLGVMALNSHKSEKKKKKFYKDSLSLAAMIRKFQKEKEAMRKKESSPKPPVTIATSTPSKIPSSSLSAGNDISDLNLKISDPVLSIFGSTNERDILQETESALEMLGDIDFDKLLDGTSDGSPVSELSGENGNVTHATYTSQVMTPKQVPALPEGLPVLLEKRIGDLRTAAKMFDEEGRKKFFTQDMNNILLDIELQLQEINPAIRNGVYSHLEAFVPCNKDTLIKRLKKLHLNVQDDRLREPLQKLKLAVSNVMPEQLCKYQEDCQARNLAKNAKLQTEDEREKNGSEEDDDEKPGKRVVGPRKKFHWDDTVRSLLCNLVKIKLGCYELEPNRSQSAEDYLKTFMETEVKPLWPKGWMQARMLFKESRSVHNHLTSAPAKKKVILAPKPKVKVNDSSPKKEQKTCISSVNSGCATTLSTGAPVCTPSSSSCTPAPETICLDDSLDEDLSFHPPSLDSISDALAVINNGAKGSPLGSAIETPTSRPRPGLREEKLASIMSKLPLATSKKVEPAQTPHSSSLIAGHTGPVPKKPQDLVHTGISSGLIAGSSIQNPKVSLEPLPAKLLQQGLQRSSQIQAAAASSQTHVSSSKTQAAISTTSQRPKDTNILVSSSEVQGGSSTSQMTKVHQHSAVQQKYVSPLQATISKSQTNPVVKLSSNPKLSCSSPVIKAQEKSVVYRLPLSNPSSGSGSQVSHPLVSRTTSSASTSSNYLAKAMVSQVSSQGFKPPFSMAASPKPAASPKPTASKPSVTPKPNASPKFSSKSTSSPRPAATPSSSSSSALVSQSSHSSNTPLHKQTGGVNISRQSPTMNLLPSNRTSGLQPAKNPQASSKLPNSSPSGTAGKNNLGGVGMNVPASRGSNLNSSGASRTSLSVGAGSGTQGATKQLSTPHRPSSASGSPVVAASVQSTAGASLLANASPLTLMASPLSVTSQNVTSAPLTPFGMLGGLVPVTVPFQFPLELLGFGTDTAGVTTTSGSTSAAFHHSLTQNLLKGLQPGAQHAAALSHSTLPAHLQQAYTDGGQSKGDTKLQRKNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TB48</accession>
    <name>A0A8C2TB48_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DIRAS family GTPase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">DIRAS2</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Displays low GTPase activity and exists predominantly in the GTP-bound form.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the small GTPase superfamily. Di-Ras family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015704877.1">
        <property type="nucleotide sequence ID" value="XM_015849391.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TB48"/>
    <dbReference type="Ensembl" id="ENSCJPT00005016286.1">
        <property type="protein sequence ID" value="ENSCJPP00005011095.1"/>
        <property type="gene ID" value="ENSCJPG00005009570.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107306312"/>
    <dbReference type="KEGG" id="cjo:107306312"/>
    <dbReference type="CTD" id="54769"/>
    <dbReference type="GeneTree" id="ENSGT00940000158196"/>
    <dbReference type="OrthoDB" id="265044at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome Z"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04140">
        <property type="entry name" value="ARHI_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000303">
        <property type="entry name" value="GTP-binding protein Di-Ras2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005011095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="199" mass="22585" checksum="ED7F9CB424377335" modified="2022-01-19" version="1">MPEQSNDYRVVVFGAGGVGKSSLVLRFVKGTFRESYIPTIEDTYRQVISCDKSICTLQITDTTGSHQFPAMQRLSISKGHAFILVYSITSRQSLEELKPIYEQICQIKGDVESIPIMLVGNKNDESQNREVESSEGEAMAKKWKCAFMETSAKLNHNVKELFQELLNLEKRRTVSLQIDGKKSKQQKRKEKLKGKCVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TB94</accession>
    <name>A0A8C2TB94_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">RING finger and CHY zinc finger domain-containing protein 1</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Androgen receptor N-terminal-interacting protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">CH-rich-interacting match with PLAG1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">E3 ubiquitin-protein ligase Pirh2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">RING-type E3 ubiquitin transferase RCHY1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Zinc finger protein 363</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="primary">RCHY1</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">E3 ubiquitin-protein ligase that mediates ubiquitination of target proteins, including p53/TP53, TP73, HDAC1 and CDKN1B. Mediates ubiquitination and degradation of p53/TP53; preferentially acts on tetrameric p53/TP53. Catalyzes monoubiquitinates the translesion DNA polymerase POLH. Involved in the ribosome-associated quality control (RQC) pathway, which mediates the extraction of incompletely synthesized nascent chains from stalled ribosomes: RCHY1 acts downstream of NEMF and recognizes CAT tails associated with stalled nascent chains, leading to their ubiquitination and degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Monomer and homodimer. Interacts with AR, MDM2, KAT5, PLAG1, PLAGL2, COPE, UBE2D2 and GORAB/NTKLBP1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2TB94"/>
    <dbReference type="Ensembl" id="ENSCJPT00005014777.1">
        <property type="protein sequence ID" value="ENSCJPP00005009923.1"/>
        <property type="gene ID" value="ENSCJPG00005008682.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000008853"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002039">
        <property type="term" value="F:p53 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032436">
        <property type="term" value="P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031398">
        <property type="term" value="P:positive regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd16464">
        <property type="entry name" value="RING-H2_Pirh2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000009">
        <property type="entry name" value="RING finger and CHY zinc finger domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000188">
        <property type="entry name" value="RING finger and CHY zinc finger domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039512">
        <property type="entry name" value="RCHY1_zinc-ribbon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008913">
        <property type="entry name" value="Znf_CHY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037274">
        <property type="entry name" value="Znf_CHY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017921">
        <property type="entry name" value="Znf_CTCHY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037275">
        <property type="entry name" value="Znf_CTCHY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21319">
        <property type="entry name" value="RING FINGER AND CHY ZINC FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21319:SF53">
        <property type="entry name" value="RING FINGER AND CHY ZINC FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05495">
        <property type="entry name" value="zf-CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14599">
        <property type="entry name" value="zinc_ribbon_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161219">
        <property type="entry name" value="CHY zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161245">
        <property type="entry name" value="Zinc hairpin stack"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51266">
        <property type="entry name" value="ZF_CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51270">
        <property type="entry name" value="ZF_CTCHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 22" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CHY-type" evidence="24">
        <location>
            <begin position="17"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="CTCHY-type" evidence="25">
        <location>
            <begin position="86"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="23">
        <location>
            <begin position="149"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00053558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00064787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00068960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00079502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00080185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00083916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00084070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00084086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005009923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="263" mass="30304" checksum="50438DED254EAA2C" modified="2022-01-19" version="1">SCGAVRGMAAVGEERRDPERAGGCEHYRRGCLLRAPCCGKLYPCRLCHDGAEEHRLDRFRVAEVQCTRCRLLQKVQQRCQGCGSLFGEYYCDVCHLFDRDRQQYHCQHCGICRIGPKEDFFHCAKCNLCLSLSLQGKHKCIENVSRQDCPICLEDIHTSRVEARVLPCGHLLHKTCYEEMLKEGYRCPLCMHSALDMRRYWRQLDDEVAQTPMPTEYQNMMVEILCNDCNSRSTVQFHLLGMKCTNCESYNTAQDGKSKQPVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TBT7</accession>
    <name>A0A8C2TBT7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fork-head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TBT7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005016634.1">
        <property type="protein sequence ID" value="ENSCJPP00005011383.1"/>
        <property type="gene ID" value="ENSCJPG00005009778.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000166634"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050211">
        <property type="entry name" value="FOX_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829:SF343">
        <property type="entry name" value="FORK-HEAD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829">
        <property type="entry name" value="FORKHEAD BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fork-head" evidence="5">
        <location>
            <begin position="123"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="4">
        <location>
            <begin position="123"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005011383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="178" mass="18889" checksum="120365CA317A4BC7" modified="2022-01-19" version="1">MWDHWALLGQAVMGVGGSLGTAWAVASPHVALVGSGASVGWGAPRGDGVGWAHRVSAGCTQKDVGSNSGLCSAPRWWVPSIPTGGSICSHPTGGSAAPGPAWCHSVLVMGLCWVWCWLWGCAGWRNSVRHNLSLNECFVKAGRSDNGKGHFWAIHPANMEDFAKGDYHRPHAAPRQWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TBZ5</accession>
    <name>A0A8C2TBZ5_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TBZ5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005016856.1">
        <property type="protein sequence ID" value="ENSCJPP00005011524.1"/>
        <property type="gene ID" value="ENSCJPG00005009910.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00990000208671"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005011524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="138" mass="16392" checksum="4E27F2B8989982D7" modified="2022-01-19" version="1">ESSRGENAIIHLPHTRSKKEGRKEGRKEGRKEEGRKEGRKEGGREGRNERKEGRKEGRKGRKEGRKEGRKEGRKEGRKEGRRNRWASVTWYFSLLTVKIRFVVFFSISRYLAFWEVRQVLWSFSFGIHSVPWVRAPHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TCF4</accession>
    <name>A0A8C2TCF4_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Tubulin epsilon 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">TUBE1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TCF4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005015710.1">
        <property type="protein sequence ID" value="ENSCJPP00005010638.1"/>
        <property type="gene ID" value="ENSCJPG00005009234.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155723"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02190">
        <property type="entry name" value="epsilon_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000007">
        <property type="entry name" value="tubulin epsilon chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000017">
        <property type="entry name" value="Tubulin epsilon chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004057">
        <property type="entry name" value="Epsilon_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01519">
        <property type="entry name" value="EPSLNTUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6 10" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="11">
        <location>
            <begin position="61"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005010638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="453" mass="50541" checksum="2BE3A42915009ED6" modified="2022-01-19" version="1">MTQSVVVQVGQCGNQVGCRFWDLALREHAAVNKKGIYDEALSSFFRNVDTRSAGDGPDIYKGKICSLKARALLIDMEEGVVNEILQGPLRDVFDSKQLITDVSGSGNNWAVGYKVYGCQYRENIVEKLRKTAEHCDCLQCFFIIHSMGGGTGSGLGTFVLNLLEDEFPEVYRFVTSVYPSGEDDVITFPYNSVLAMKELNEHADCVLPIENESLFDIVNKIHQMVNSGKLGSTVKPNSLVTSSAGTAKTVQEKPFDAMNNIVANLLLNLTSSARFEGSLNMDLNEITDNWFFSSPRLDQMFSDAFSRDHQLIRSDPKHSLYLACALLVRGNVQVSDLRRNIERLKPSLHFVSWNQEGWKTSLCSVPPVGHSHSLLALANNTCVKPTFMELKDRFMKLYKKKAHLHHYLQVDGMEQGCFSEAISSLSDLIEEYNELDATKGGLRTDPSRLKIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TCK9</accession>
    <name>A0A8C2TCK9_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tetratricopeptide repeat domain 34</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">TTC34</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_032304632.1">
        <property type="nucleotide sequence ID" value="XM_032448741.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032304633.1">
        <property type="nucleotide sequence ID" value="XM_032448742.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032304634.1">
        <property type="nucleotide sequence ID" value="XM_032448743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TCK9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005016131.1">
        <property type="protein sequence ID" value="ENSCJPP00005010982.1"/>
        <property type="gene ID" value="ENSCJPG00005009495.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107323255"/>
    <dbReference type="CTD" id="100287898"/>
    <dbReference type="GeneTree" id="ENSGT00390000003047"/>
    <dbReference type="OrthoDB" id="5971337at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056836">
        <property type="entry name" value="ARM_TT21_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042161">
        <property type="entry name" value="TTC34"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44874">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44874:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25068">
        <property type="entry name" value="ARM_TT21_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13174">
        <property type="entry name" value="TPR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Tetratricopeptide repeat protein 21A/21B fourth ARM" evidence="3">
        <location>
            <begin position="870"/>
            <end position="968"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005010982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1041" mass="116705" checksum="A867FE79FB0A1617" modified="2022-01-19" version="1">MSPQGLAVLLCREGDQHLAQQELPTATAFYVAAFSCSAPTALQKVNSLENGLWERVIATLEMWCRGKSQIPKIQSRNVAIASLRVEIAAVFLSTLSPDNVLSSIYKLEALLRRGCSEEVVSKCNVLLKAHPEYSVELLLLRALAWVLSGTQIRKGVADYIQVFVRHQAEAVAYVCTRQKEHLPQIIQAFSNFLSTYQKESPDGSSLDHWLGNCYAFLSAVAPGDVWVCRAQAAYLFKKSKFEECVAVCSKALKGLSVDNSLRDEKMLGLLLERAAAYFFLGGRMQEMMQDLAEAFAATPDLAMKHFEELFSPPDTERIEEQARTVLEVKFAAYREAVRARTELRSNRCSELLPSVIQTVLFLLRISPGSKRELSVRLADCHLLHGHIGAALEICDQLLAAEQKTYHNTLLALRGFCALHSHDHQQALQDFQKVIEHDSPHPNSCIKALCGRGLIRISGGSHYLTALDYITACQLKLEETIFTIKAYVPWNQRGLLLKVLQEEGQKMLQKKRDALGVYQLASLLMELDPSDEASRILCADALYQMGWVEEAHKLLSLALSRNPQRSPILARLALLQLKKGFMYDGNQLLKKVIRIGDTSCLLPIMDIFKDEDRKLMQTHCRSKALSILKNKQEDADIKEAIAYLSFAIIASGGYAEDCLLIRAQCYGHLGQKKTAIFDFNAVLKEDPGNVHALSGRGLIYLALKQQKEAVQDLTLALKAEAGMVIPAILSLKHEAQELVAQWLLQHSRTVLAELIATKDFSKEERTLRDLLVIAGALIKIRKEGQYHIFYTDVLIANGRYEEALVHLQEVFGHSLADELASARLAVLQLKKRNVPAAAQSFSILAKKDERELEFLLNFVDAKQQQHLSQVAAQEGNVLIKGHHYKKAVGFFTLAILTSKDNPRYLRQRAACFMHLKKYDKALKDMEKVIEKHGCNSLRTRVQDHCSKGHLLLSVSEEEAAVKQYIEALQLDESTALCSIMNGSGSESVAKTFHKIAQCNFEMQHYEEAWKITDYGLKIDQNNPDLKKLKTRLKREASGCSIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TCS9</accession>
    <name>A0A8C2TCS9_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">4-hydroxybenzoate polyprenyltransferase, mitochondrial</fullName>
            <shortName evidence="14">4-HB polyprenyltransferase</shortName>
            <ecNumber evidence="14">2.5.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Para-hydroxybenzoate--polyprenyltransferase</fullName>
            <shortName evidence="14">PHB:PPT</shortName>
            <shortName evidence="14">PHB:polyprenyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14 15" type="primary">COQ2</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>all-trans-decaprenyl diphosphate + 4-hydroxybenzoate = 4-hydroxy-3-(all-trans-decaprenyl)benzoate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:44564"/>
            <dbReference type="ChEBI" id="CHEBI:17879"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60721"/>
            <dbReference type="ChEBI" id="CHEBI:84503"/>
            <dbReference type="EC" id="2.5.1.39"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:44565"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>all-trans-nonaprenyl diphosphate + 4-hydroxybenzoate = 4-hydroxy-3-(all-trans-nonaprenyl)benzoate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:17709"/>
            <dbReference type="ChEBI" id="CHEBI:17879"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58391"/>
            <dbReference type="ChEBI" id="CHEBI:84502"/>
            <dbReference type="EC" id="2.5.1.39"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:17710"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>an all-trans-polyprenyl diphosphate + 4-hydroxybenzoate = a 4-hydroxy-3-(all-trans-polyprenyl)benzoate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:44504"/>
            <dbReference type="Rhea" id="RHEA-COMP:9514"/>
            <dbReference type="Rhea" id="RHEA-COMP:9564"/>
            <dbReference type="ChEBI" id="CHEBI:17879"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58914"/>
            <dbReference type="ChEBI" id="CHEBI:78396"/>
            <dbReference type="EC" id="2.5.1.39"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:44505"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 14">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Mitochondrion inner membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
            <orientation evidence="14">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.39" evidence="14"/>
    <dbReference type="RefSeq" id="XP_015717111.1">
        <property type="nucleotide sequence ID" value="XM_015861625.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TCS9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005017108.1">
        <property type="protein sequence ID" value="ENSCJPP00005011734.1"/>
        <property type="gene ID" value="ENSCJPG00005010052.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107313429"/>
    <dbReference type="KEGG" id="cjo:107313429"/>
    <dbReference type="CTD" id="27235"/>
    <dbReference type="GeneTree" id="ENSGT00940000153771"/>
    <dbReference type="OrthoDB" id="18170at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008412">
        <property type="term" value="F:4-hydroxybenzoate polyprenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13959">
        <property type="entry name" value="PT_UbiA_COQ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1780:FF:000001">
        <property type="entry name" value="4-hydroxybenzoate octaprenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.140:FF:000003">
        <property type="entry name" value="4-hydroxybenzoate polyprenyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1780">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01635">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006370">
        <property type="entry name" value="HB_polyprenyltransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039653">
        <property type="entry name" value="Prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01474">
        <property type="entry name" value="ubiA_proteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048:SF28">
        <property type="entry name" value="4-HYDROXYBENZOATE POLYPRENYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048">
        <property type="entry name" value="PRENYLTRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6 14" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="282"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00050454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00051182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005011734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="372" mass="40896" checksum="99E182E9F2A32F3F" modified="2022-01-19" version="1">MRYGAPHRPAGRASGYDKMAALLLGLSRASCRLHAARPALPAAIVAPRRPAAPLGSRRPLSFSAAELVRAAPGPLRPYLHLMRLHQPAGTWLLYLPCTWSIGLAAEPGCLPDWHMLTLFGAGAVLMRGAGCTINDLWDRDYDKQVARTAGRPLAAGEISTFQSFIFLGGQLSLALCVLLCLNYYSIMLGAASLSLVITYPLMKRITYWPQLVLGLTFNWGALLGWSAVQGSCNWSVCLPLYFAGVMWTLVYDTIYAHQDKRDDIIIGVKSTALKFKEDTKQWLSGFSTAMVLGLCVAGMNCDQTFPYYSAVAAVGAHLAHQIYTLDIDKPEDCWKKFASNRTVGVLLFVGIVLGNLWKRKNSETVEEPLERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TDT5</accession>
    <name>A0A8C2TDT5_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Anaphase-promoting complex subunit 16</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Cyclosome subunit 16</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">ANAPC16</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the APC16 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015721925.1">
        <property type="nucleotide sequence ID" value="XM_015866439.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TDT5"/>
    <dbReference type="SMR" id="A0A8C2TDT5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005016488.1">
        <property type="protein sequence ID" value="ENSCJPP00005011249.1"/>
        <property type="gene ID" value="ENSCJPG00005009688.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107315752"/>
    <dbReference type="KEGG" id="cjo:107315752"/>
    <dbReference type="CTD" id="119504"/>
    <dbReference type="GeneTree" id="ENSGT00390000018109"/>
    <dbReference type="OrthoDB" id="6374621at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141198">
        <property type="term" value="P:protein branched polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070936">
        <property type="term" value="P:protein K48-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029641">
        <property type="entry name" value="APC16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31564">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31564:SF0">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17256">
        <property type="entry name" value="ANAPC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9" id="KW-0132">Cell division</keyword>
    <keyword evidence="15" id="KW-0137">Centromere</keyword>
    <keyword evidence="7" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00045696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005011249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="134" mass="14589" checksum="B01156353234B6D3" modified="2022-01-19" version="1">MHRERDHARRLRQAVRAPRLGRGEMAASSSSSSAGGVSGSSVTGSGFSVSDLAPPRKALFTYPKGAGEMLEDGSERFLCESVFSYQVASTLKQVKHDQQVARMEKLAGLVEELEADEWRYKPIEQLLGFTPSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TEI3</accession>
    <name>A0A8C2TEI3_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1</fullName>
            <ecNumber evidence="15">2.4.3.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Gal-NAc6S</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">ST3Gal I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">ST3GalA.1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">ST3O</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Sialyltransferase 4A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="primary">ST3GAL1</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">Golgi stack membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 29 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.3.4" evidence="15"/>
    <dbReference type="RefSeq" id="XP_015711836.1">
        <property type="nucleotide sequence ID" value="XM_015856350.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015711837.1">
        <property type="nucleotide sequence ID" value="XM_015856351.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015711838.1">
        <property type="nucleotide sequence ID" value="XM_015856352.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015711839.1">
        <property type="nucleotide sequence ID" value="XM_015856353.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032298801.1">
        <property type="nucleotide sequence ID" value="XM_032442910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TEI3"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="TreeGrafter"/>
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</entry>
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                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="153" mass="17195" checksum="C8023CF106AC3FEB" modified="2022-01-19" version="1">MGMCSRQERIQKDIDVVIQKCKAEKDCLFADFRYSDSTFTFTYIGGSKSLFRGAVPPSQGMSGYSALELLFAREPWVPPQPPFCYMQTSSTGFRMGTQIVSRLVGCSENAFPATVPCLLQLEEEQHMSFSVEQRSRSLTRESDVLSGCLKYTL</sequence>
</entry>
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    <accession>A0A8C2TGT1</accession>
    <name>A0A8C2TGT1_COTJA</name>
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        <submittedName>
            <fullName evidence="9">RELT like 2</fullName>
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        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
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            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
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                <person name="Warren W."/>
                <person name="Burt D.W."/>
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                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
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                <consortium name="Ensembl"/>
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                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <subcellularLocation>
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        <text evidence="2">Belongs to the RELT family.</text>
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    <dbReference type="KEGG" id="cjo:107320291"/>
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    <dbReference type="GeneTree" id="ENSGT00940000160541"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:collagen binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010811">
        <property type="term" value="P:positive regulation of cell-substrate adhesion"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="RELL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022248">
        <property type="entry name" value="TNF_rcpt_RELT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31481:SF0">
        <property type="entry name" value="RELT-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31481">
        <property type="entry name" value="RELT-LIKE PROTEIN 2 RELL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12606">
        <property type="entry name" value="RELT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="144"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="144"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="238"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="314"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="327"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005013547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="350" mass="38255" checksum="B6184081C63D7DA5" modified="2022-01-19" version="1">MSDQSSSEDGESDSQHSLYMVFLLVLVFFIMGLVGFLICHVLKKKGYRCRTFRDELDPDNKDVLAELQANEEEEINEDTVEKIVRCIIQNEANAEALKEMLGDNDGDIAVPMPSLCPHRNSQDGGPPHHHTVHLGSTQAPCIHCSKRRRHPLHRQGRSKDGKGRMHPGETTVFSVGRFRVTHIGKKPAFHEQQDGAQPDGSKEPSTEELEHSSERFQREQAHNGTVPMRSLENGAVQEGTQGSKGMEQSRTGTPVPGTAVGSSPGSTSRQRRLLSRRVLGGSSPSIPGQLGQEEAGLGSADEVSDIHGSLSLHEVPDEMVREDSSRRQPGTENVGQQEPSAVVQDRGATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TH68</accession>
    <name>A0A8C2TH68_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Myotubularin related protein 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">MTMR7</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015717745.1">
        <property type="nucleotide sequence ID" value="XM_015862259.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TH68"/>
    <dbReference type="Ensembl" id="ENSCJPT00005018009.1">
        <property type="protein sequence ID" value="ENSCJPP00005012432.1"/>
        <property type="gene ID" value="ENSCJPG00005010576.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107313730"/>
    <dbReference type="KEGG" id="cjo:107313730"/>
    <dbReference type="CTD" id="9108"/>
    <dbReference type="GeneTree" id="ENSGT00940000155777"/>
    <dbReference type="OrthoDB" id="271628at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106018">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004438">
        <property type="term" value="F:phosphatidylinositol-3-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd13344">
        <property type="entry name" value="PH-GRAM_MTMR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14583">
        <property type="entry name" value="PTP-MTMR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000135">
        <property type="entry name" value="Myotubularin related protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036003">
        <property type="entry name" value="MTMR7_PH-GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030572">
        <property type="entry name" value="MTMR7_PTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030564">
        <property type="entry name" value="Myotubularin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010569">
        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048994">
        <property type="entry name" value="PH-GRAM_MTMR6-9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807">
        <property type="entry name" value="MYOTUBULARIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807:SF35">
        <property type="entry name" value="MYOTUBULARIN-RELATED PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06602">
        <property type="entry name" value="Myotub-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21098">
        <property type="entry name" value="PH-GRAM_MTMR6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51339">
        <property type="entry name" value="PPASE_MYOTUBULARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myotubularin phosphatase" evidence="12">
        <location>
            <begin position="126"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="11">
        <location>
            <begin position="307"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="553"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="521"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="558"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="569"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="7">
        <location>
            <position position="338"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="275"/>
            <end position="276"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="338"/>
            <end position="344"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005012432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="659" mass="75509" checksum="8AC987959E11141A" modified="2022-01-19" version="1">MEHIRMPKVENVRLLDRLSSRKATVGTLYLTATHVIFVENGSETRKETWVLHSQISSIEKQATTATGCPLLIRCKNFQVIQLVIPQERDCHDVYISLIRLTRPVKYEELYCFSFNPKLDKEEREKGWKLVDLKEEYNRMGIPNSYWQISDVNRDYGVCDSYPTEVYVPKSATAHIIVGSSKFRSRRRFPALSYYCKDNNASICRSSQPLSGFSARCLEDEQMLQAIRKANPGSDFIYVVDTRPKLNAMANRAAGKGYENEDNYSNIKFQFIGIENIHVMRNSLQKMLEVCEMKSPSMSDFLWGLENSGWLKHIKAIMDAGIFIAKAVAEQGVSVLVHCSDGWDRTAQVCSVASLLLDPHYRTMKGFMVLIEKDWVSFGHKFNHRYGNLDGDPKEISPVIDQFIECVWQLMEQFPCAFEFNERFLIHLQHHIYSCQFGNFLCNSQKERRELKIQERTYSLWAHLWKNRADYLNPLYRPDHSQTWGTLHPQMAPCNFLYKFWSGMYNRFEKGLHPRQSVTDYLMAVKEETQQLEEELAVLGERLANLQKLQLNGNKVKSKQQDRSKELKLSASNNSIANTPQEYSNDLKSFPSRSPSQGDEEDSALILTQDNLKSSDPDLSANSDQESGVEDLSCRSPSAGGCLPSEDSGKDSDEAVCLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2THK8</accession>
    <name>A0A8C2THK8_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">t-SNARE domain containing 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TSNARE1</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015711900.2">
        <property type="nucleotide sequence ID" value="XM_015856414.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032298817.1">
        <property type="nucleotide sequence ID" value="XM_032442926.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032298818.1">
        <property type="nucleotide sequence ID" value="XM_032442927.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032298819.1">
        <property type="nucleotide sequence ID" value="XM_032442928.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032298820.1">
        <property type="nucleotide sequence ID" value="XM_032442929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2THK8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005017841.1">
        <property type="protein sequence ID" value="ENSCJPP00005012296.1"/>
        <property type="gene ID" value="ENSCJPG00005010465.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005017842.1">
        <property type="protein sequence ID" value="ENSCJPP00005012297.1"/>
        <property type="gene ID" value="ENSCJPG00005010465.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005017843.1">
        <property type="protein sequence ID" value="ENSCJPP00005012298.1"/>
        <property type="gene ID" value="ENSCJPG00005010465.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005017844.1">
        <property type="protein sequence ID" value="ENSCJPP00005012299.1"/>
        <property type="gene ID" value="ENSCJPG00005010465.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005017845.1">
        <property type="protein sequence ID" value="ENSCJPP00005012300.1"/>
        <property type="gene ID" value="ENSCJPG00005010465.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107310603"/>
    <dbReference type="KEGG" id="cjo:107310603"/>
    <dbReference type="CTD" id="203062"/>
    <dbReference type="GeneTree" id="ENSGT01000000214440"/>
    <dbReference type="OrthoDB" id="75754at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008021">
        <property type="term" value="C:synaptic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15847">
        <property type="entry name" value="SNARE_syntaxin7_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.70:FF:000014">
        <property type="entry name" value="t-SNARE domain containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000121">
        <property type="entry name" value="t-SNARE domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF212">
        <property type="entry name" value="T-SNARE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14523">
        <property type="entry name" value="Syntaxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00503">
        <property type="entry name" value="SynN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="6">
        <location>
            <begin position="192"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="106"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="230"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005012296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="289" mass="31791" checksum="676439B1F135F839" modified="2022-01-19" version="1">MSYGSIDGSGFGRNPFGGPSRQGYQPLATQIDPSELQELFQETSANVFRINSSVTSLERSLRSLGTPNDTQELQDGLHATQQETNKTITTSTKAIKQLSEVVRGSSRQERLQLDRLKNQLSDAIQRYGAVQKKIAEKSKALLPTGPRSSKQSPRTPFSDLADDEKIFNGGDGTWQKQSQDQALLSEITEEDLEAIRQREEAIQQIESDMLDVNQIIKDLASMVHEQGDTIDSIEANIETASSNVESANEQLAKASQHQLRARKMKCCLLSAAVAVLLFIVIIIAVSVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2THU1</accession>
    <name>A0A8C2THU1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytotoxic granule associated RNA binding protein TIA1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">RNA-binding protein TIA-1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">T-cell-restricted intracellular antigen-1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">TIA1</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="11">Homooligomer; homooligomerization is induced by Zn(2+). Interacts with FASTK; the interactions leads to its phosphorylation. Interacts (via RRM1 and the C-terminal glutamine-rich (Q) sequence) with SNRPC/U1-C (via N-terminus); thereby facilitating spliceosomal U1 snRNP recruitment to 5' splice sites.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Stress granule</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2THU1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005020005.1">
        <property type="protein sequence ID" value="ENSCJPP00005013985.1"/>
        <property type="gene ID" value="ENSCJPG00005011733.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154962"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097165">
        <property type="term" value="C:nuclear stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001818">
        <property type="term" value="P:negative regulation of cytokine production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903608">
        <property type="term" value="P:protein localization to cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd12615">
        <property type="entry name" value="RRM1_TIA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12618">
        <property type="entry name" value="RRM2_TIA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12620">
        <property type="entry name" value="RRM3_TIAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000951">
        <property type="entry name" value="nucleolysin TIA-1 isoform X7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000038">
        <property type="entry name" value="Nucleolysin tiar isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000045">
        <property type="entry name" value="Nucleolysin tiar isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034827">
        <property type="entry name" value="TIA-1_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034830">
        <property type="entry name" value="TIA1_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034496">
        <property type="entry name" value="TIAR_RRM3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10352">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 15" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="7"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="106"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="214"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00065184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00077097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00083589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005013985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="383" mass="42466" checksum="40FAF327B41D8D7D" modified="2022-01-19" version="1">MEDEMPKTLYVGNLSRDVTEALILQLFSQIGPCKNCKMIMDTAGNDPYCFVEFYEHRHAASALAAMNGRKIMGKEVKVNWATTPSSQKKDTSSSTVVSTQRSQDHFHVFVGDLSPEITTEDIKAAFAPFGRISDARVVKDMATGKSKGYGFVSFFNKWDAENAIQQMGGQWLGGRQIRTNWATRKPPAPKSTYESNTKQLSYDDVVNQSSPSNCTVYCGGVTSGLTEQLMRQTFSPFGQIMEIRVFPDKGYSFVRFNSHESAAHAIVSVNGTTIEGHVVKCYWGKETPDMVSPVQQNQIGYPQAYGQWGQWYGNAQLGQYVPNGWQVPAYGMYGQPWNQQGFNQTQSSAAWMGANYSVQPPQGQNGSVLTNQAGYRVAGFETQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TIP1</accession>
    <name>A0A8C2TIP1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rab9 effector protein with kelch motifs</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">RABEPK</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Rab9 effector required for endosome to trans-Golgi network (TGN) transport.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015734937.1">
        <property type="nucleotide sequence ID" value="XM_015879451.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TIP1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005018862.1">
        <property type="protein sequence ID" value="ENSCJPP00005013088.1"/>
        <property type="gene ID" value="ENSCJPG00005011067.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107321943"/>
    <dbReference type="KEGG" id="cjo:107321943"/>
    <dbReference type="CTD" id="10244"/>
    <dbReference type="GeneTree" id="ENSGT00940000158763"/>
    <dbReference type="OrthoDB" id="10251809at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052124">
        <property type="entry name" value="Rab9_kelch_effector"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46647">
        <property type="entry name" value="RAB9 EFFECTOR PROTEIN WITH KELCH MOTIFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46647:SF1">
        <property type="entry name" value="RAB9 EFFECTOR PROTEIN WITH KELCH MOTIFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005013088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="371" mass="40047" checksum="233D669308F448E0" modified="2022-01-19" version="1">MGPLLPPLLEPGSRPRAGKWYRLAPRGEWPRGRVGHGCVLVPGGSGRVLLLGGADPAGAFADAHFVELDTHRWAPAAWSGLRPRYEHATFLPARLPTRLWVFGGAHPAGNRSCVQVLDPEIGTWESPEVTGVPPLPRTFHTSSAALGTCLYVFGGGDKGAEPVKDQQLHVFDTDALTWTQPGTHGDPPSPRHGHVIVAVGTKLFIHGGLAGDIFYDDLFCIDTTDMKWVKIAATGDVPGGRASHSSTVFKDHLYIFGGIGPDGTLDTTYKYHIEEQKWTLLQFDSPLPAGRLDHAMCVIPWRVGKNGDTGAVTRDDKAEPTASAGDRAEHLCGGQDEKACTEDTMVHLLLIFGGMDTQAEIYRDCIVSLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TJF9</accession>
    <name>A0A8C2TJF9_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">YWHAH</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 14-3-3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015733835.1">
        <property type="nucleotide sequence ID" value="XM_015878349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TJF9"/>
    <dbReference type="SMR" id="A0A8C2TJF9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005019039.1">
        <property type="protein sequence ID" value="ENSCJPP00005013211.1"/>
        <property type="gene ID" value="ENSCJPG00005011165.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107321448"/>
    <dbReference type="KEGG" id="cjo:107321448"/>
    <dbReference type="CTD" id="7533"/>
    <dbReference type="GeneTree" id="ENSGT01140000282547"/>
    <dbReference type="OrthoDB" id="10260625at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0150048">
        <property type="term" value="C:cerebellar granule cell to Purkinje cell synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035259">
        <property type="term" value="F:nuclear glucocorticoid receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017080">
        <property type="term" value="F:sodium channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044325">
        <property type="term" value="F:transmembrane transporter binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006713">
        <property type="term" value="P:glucocorticoid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0086010">
        <property type="term" value="P:membrane depolarization during action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050774">
        <property type="term" value="P:negative regulation of dendrite morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042921">
        <property type="term" value="P:nuclear receptor-mediated glucocorticoid signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099171">
        <property type="term" value="P:presynaptic modulation of chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002028">
        <property type="term" value="P:regulation of sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.190.20:FF:000001">
        <property type="entry name" value="14-3-3 gamma 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.20">
        <property type="entry name" value="14-3-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000308">
        <property type="entry name" value="14-3-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023409">
        <property type="entry name" value="14-3-3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036815">
        <property type="entry name" value="14-3-3_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023410">
        <property type="entry name" value="14-3-3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18860">
        <property type="entry name" value="14-3-3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00244">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000868">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00305">
        <property type="entry name" value="1433ZETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00101">
        <property type="entry name" value="14_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48445">
        <property type="entry name" value="14-3-3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00796">
        <property type="entry name" value="1433_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00797">
        <property type="entry name" value="1433_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="14-3-3" evidence="4">
        <location>
            <begin position="4"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000868-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005013211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="247" mass="28342" checksum="A0ACABBA7A484353" modified="2022-01-19" version="1">MGDREQLLQRARLAEQAERYDDMASAMKSVTELNEPLSNEDRNLLSVAYKNVVGARRSSWRVISSIEQKTMADGNEKKLEKVKAYREKIEKELETVCNDVLALLDKYLIKNCNDFQYESKVFYLKMKGDYYRYLAEVAAGEKKNSVVEASEAAYKEAFEISKEHMQPTHPIRLGLALNFSVFYYEIQNAPEQACLLAKQAFDDAIAELDTLNEDSYKDSTLIMQLLRDNLTLWTSDQQDEEAGEGNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TJQ4</accession>
    <name>A0A8C2TJQ4_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein Wnt</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">WNT2</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Ligand for members of the frizzled family of seven transmembrane receptors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Secreted</location>
            <location evidence="1 9">Extracellular space</location>
            <location evidence="1 9">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Wnt family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TJQ4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005020744.1">
        <property type="protein sequence ID" value="ENSCJPP00005014594.1"/>
        <property type="gene ID" value="ENSCJPG00005012164.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159231"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005109">
        <property type="term" value="F:frizzled binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055009">
        <property type="term" value="P:atrial cardiac muscle tissue morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060317">
        <property type="term" value="P:cardiac epithelial to mesenchymal transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060038">
        <property type="term" value="P:cardiac muscle cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045165">
        <property type="term" value="P:cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033278">
        <property type="term" value="P:cell proliferation in midbrain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007267">
        <property type="term" value="P:cell-cell signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071560">
        <property type="term" value="P:cellular response to transforming growth factor beta stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060502">
        <property type="term" value="P:epithelial cell proliferation involved in lung morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060492">
        <property type="term" value="P:lung induction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010463">
        <property type="term" value="P:mesenchymal cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904948">
        <property type="term" value="P:midbrain dopaminergic neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060045">
        <property type="term" value="P:positive regulation of cardiac muscle cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060501">
        <property type="term" value="P:positive regulation of epithelial cell proliferation involved in lung morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048146">
        <property type="term" value="P:positive regulation of fibroblast proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002053">
        <property type="term" value="P:positive regulation of mesenchymal cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050769">
        <property type="term" value="P:positive regulation of neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2460.20:FF:000001">
        <property type="entry name" value="Wnt homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2460.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005817">
        <property type="entry name" value="Wnt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043158">
        <property type="entry name" value="Wnt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018161">
        <property type="entry name" value="Wnt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027:SF86">
        <property type="entry name" value="PROTEIN WNT-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027">
        <property type="entry name" value="WNT RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00110">
        <property type="entry name" value="wnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01349">
        <property type="entry name" value="WNTPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00097">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00246">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 9" id="KW-0879">Wnt signaling pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005014594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="321" mass="36022" checksum="83FDB5752728991C" modified="2022-01-19" version="1">MCDNVPGLVSRQRQLCRRHPEAMMSIGRGVAAWTAECQHQFRRHRWDCSALERGQRLLGRVLQRSSRESAFVHAISSAGVVFAITRACSQGELKSCSCDPEKKGSAKDSKGRFDWGGCSDNIDYGVKFARAFVDAKERKGKDARALMNLHNNRAGRKAVKRFLKQECKCHGVSGSCTLRTCWLAMADFRKTGDYLWKKYNGAIQVVMNQDGTGFTVANKRFKKPTKNDLVYFESSPDYCIRDRDVGSPGTAGRVCNQTSRGMDSCEVMCCGRGYDTLRVSRMTKCECKFHWCCAVRCQDCLEEVDIHTCKAPKAAGWASRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TLH6</accession>
    <name>A0A8C2TLH6_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytoplasmic FMR1 interacting protein 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TLH6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005019314.1">
        <property type="protein sequence ID" value="ENSCJPP00005013450.1"/>
        <property type="gene ID" value="ENSCJPG00005011342.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00500000044831"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008081">
        <property type="entry name" value="Cytoplasmic_FMR1-int"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12195">
        <property type="entry name" value="CYTOPLASMIC FMR1-INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005013450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="115" mass="13003" checksum="E6957101B7F668C0" modified="2022-01-19" version="1">MTTHVTLEDALSNVDLLEELPLPDQQPCIEPPPSSIMYQANFDTNFEDRNAFVTGIARYIEQATVHSSMNEMLEEGHEYAVMLYTWRSCSRAIPQVCVVLSSMDQFGSVWGGDRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TP17</accession>
    <name>A0A8C2TP17_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phospholipase A and acyltransferase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">PLAAT1</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the H-rev107 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015727235.1">
        <property type="nucleotide sequence ID" value="XM_015871749.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015727237.1">
        <property type="nucleotide sequence ID" value="XM_015871751.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TP17"/>
    <dbReference type="Ensembl" id="ENSCJPT00005023186.1">
        <property type="protein sequence ID" value="ENSCJPP00005016506.1"/>
        <property type="gene ID" value="ENSCJPG00005013552.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107318202"/>
    <dbReference type="KEGG" id="cjo:107318202"/>
    <dbReference type="CTD" id="57110"/>
    <dbReference type="GeneTree" id="ENSGT00940000156634"/>
    <dbReference type="OrthoDB" id="421951at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016410">
        <property type="term" value="F:N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008970">
        <property type="term" value="F:phospholipase A1 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070292">
        <property type="term" value="P:N-acylphosphatidylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.10">
        <property type="entry name" value="endopeptidase domain like (from Nostoc punctiforme)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051496">
        <property type="entry name" value="H-rev107_PLA/AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007053">
        <property type="entry name" value="LRAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13943">
        <property type="entry name" value="HRAS-LIKE SUPPRESSOR - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13943:SF37">
        <property type="entry name" value="PHOSPHOLIPASE A AND ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04970">
        <property type="entry name" value="LRAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51934">
        <property type="entry name" value="LRAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="LRAT" evidence="6">
        <location>
            <begin position="20"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005016506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="169" mass="18702" checksum="E4F72D959D336783" modified="2022-01-19" version="1">MAAIGSFSAAHPGDPQPGDLIEIFRPAYQHWALYLGDGYIINVTPVEEGPPATFGSAKSVFSRKAMVRMQLLKEVVGNDTYRINNKYDGTYAPLPVEDIIRRAEYLINQEVSYDLLGNNCEHFVTLLRYGEGVSEQANRAISAIGFVTAAAGAFSLLGLLRSRNRERQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TPA0</accession>
    <name>A0A8C2TPA0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Rieske domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">RFESD</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TPA0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005021817.1">
        <property type="protein sequence ID" value="ENSCJPP00005015372.1"/>
        <property type="gene ID" value="ENSCJPG00005012760.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000018225"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome Z"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03467">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.102.10.10:FF:000009">
        <property type="entry name" value="Rieske Fe-S domain containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054716">
        <property type="entry name" value="Sol_Rieske_ferrdox_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21496">
        <property type="entry name" value="FERREDOXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21496:SF0">
        <property type="entry name" value="RIESKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22543">
        <property type="entry name" value="Rieske_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Rieske" evidence="10">
        <location>
            <begin position="11"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="152" mass="17221" checksum="5ACB2AF240E311CD" modified="2022-01-19" version="1">VQIETEPDGLVLVGKEDDIIKSQRITAKVNGREVVVFYREGRFYALDSRCYHEGGPLHLGEIEDINGQPCIICPWHKYTIALETGEGLYQGVNPLEPSPTPQWQSKGVKQRIYKVTVQNKNVYVSPPDLSVSFDSDYFAEKYKNEGDLAMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TPK9</accession>
    <name>A0A8C2TPK9_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="24">Hedgehog protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="28" type="primary">IHH</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="28" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="28" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <molecule>Protein hedgehog N-product</molecule>
        <text evidence="24">The dually lipidated hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development.</text>
    </comment>
    <comment type="function">
        <molecule>Protein hedgehog</molecule>
        <text evidence="24">The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product). In addition, the C-terminal part displays a cholesterol transferase activity that results by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product.</text>
    </comment>
    <comment type="subunit">
        <text evidence="21">Interacts with BOC and CDON. Interacts with PTCH1. Interacts with glypican GPC3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="20">Multimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="subcellular location">
        <molecule>Sonic hedgehog protein</molecule>
        <subcellularLocation>
            <location evidence="24">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="24">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="subcellular location">
        <molecule>Protein hedgehog N-product</molecule>
        <subcellularLocation>
            <location evidence="24">Cell membrane</location>
            <topology evidence="24">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 24">Belongs to the hedgehog family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015724713.1">
        <property type="nucleotide sequence ID" value="XM_015869227.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TPK9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005022438.1">
        <property type="protein sequence ID" value="ENSCJPP00005015885.1"/>
        <property type="gene ID" value="ENSCJPG00005013116.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107317031"/>
    <dbReference type="KEGG" id="cjo:107317031"/>
    <dbReference type="CTD" id="3549"/>
    <dbReference type="GeneTree" id="ENSGT00940000159207"/>
    <dbReference type="OrthoDB" id="5212at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005113">
        <property type="term" value="F:patched binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045453">
        <property type="term" value="P:bone resorption"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001569">
        <property type="term" value="P:branching involved in blood vessel morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060220">
        <property type="term" value="P:camera-type eye photoreceptor cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001708">
        <property type="term" value="P:cell fate specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048469">
        <property type="term" value="P:cell maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007267">
        <property type="term" value="P:cell-cell signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060591">
        <property type="term" value="P:chondroblast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003413">
        <property type="term" value="P:chondrocyte differentiation involved in endochondral bone morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035988">
        <property type="term" value="P:chondrocyte proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048596">
        <property type="term" value="P:embryonic camera-type eye morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048557">
        <property type="term" value="P:embryonic digestive tract morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042733">
        <property type="term" value="P:embryonic digit morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009880">
        <property type="term" value="P:embryonic pattern specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072498">
        <property type="term" value="P:embryonic skeletal joint development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003382">
        <property type="term" value="P:epithelial cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090136">
        <property type="term" value="P:epithelial cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060323">
        <property type="term" value="P:head morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001947">
        <property type="term" value="P:heart looping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035264">
        <property type="term" value="P:multicellular organism growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046639">
        <property type="term" value="P:negative regulation of alpha-beta T cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032331">
        <property type="term" value="P:negative regulation of chondrocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048074">
        <property type="term" value="P:negative regulation of eye pigmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033088">
        <property type="term" value="P:negative regulation of immature T cell proliferation in thymus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048666">
        <property type="term" value="P:neuron development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001649">
        <property type="term" value="P:osteoblast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031016">
        <property type="term" value="P:pancreas development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046638">
        <property type="term" value="P:positive regulation of alpha-beta T cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032967">
        <property type="term" value="P:positive regulation of collagen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002053">
        <property type="term" value="P:positive regulation of mesenchymal cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045880">
        <property type="term" value="P:positive regulation of smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033089">
        <property type="term" value="P:positive regulation of T cell differentiation in thymus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016540">
        <property type="term" value="P:protein autoprocessing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006029">
        <property type="term" value="P:proteoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040008">
        <property type="term" value="P:regulation of growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003406">
        <property type="term" value="P:retinal pigment epithelium development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048745">
        <property type="term" value="P:smooth muscle tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007224">
        <property type="term" value="P:smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061053">
        <property type="term" value="P:somite development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030704">
        <property type="term" value="P:vitelline membrane formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00081">
        <property type="entry name" value="Hint"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.16.10:FF:000001">
        <property type="entry name" value="Indian hedgehog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1380.10:FF:000001">
        <property type="entry name" value="Indian hedgehog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.16.10">
        <property type="entry name" value="Hedgehog/Intein (Hint) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001657">
        <property type="entry name" value="Hedgehog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001767">
        <property type="entry name" value="Hedgehog_Hint"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050387">
        <property type="entry name" value="Hedgehog_Signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000320">
        <property type="entry name" value="Hedgehog_signalling_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003586">
        <property type="entry name" value="Hint_dom_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003587">
        <property type="entry name" value="Hint_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009045">
        <property type="entry name" value="Zn_M74/Hedgehog-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11889">
        <property type="entry name" value="HEDGEHOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11889:SF39">
        <property type="entry name" value="INDIAN HEDGEHOG PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01085">
        <property type="entry name" value="HH_signal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01079">
        <property type="entry name" value="Hint"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009400">
        <property type="entry name" value="Peptidase_C46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00632">
        <property type="entry name" value="SONICHHOG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00305">
        <property type="entry name" value="HintC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00306">
        <property type="entry name" value="HintN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55166">
        <property type="entry name" value="Hedgehog/DD-peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="Hedgehog/intein (Hint) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="13 24" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="16 24" id="KW-0333">Golgi apparatus</keyword>
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        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
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        <location>
            <begin position="24"/>
            <end position="408"/>
        </location>
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        </location>
    </feature>
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        <location>
            <position position="90"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
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        <location>
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        <location>
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            <dbReference type="ChEBI" id="CHEBI:29108"/>
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        <location>
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            <label>2</label>
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            <position position="132"/>
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        </ligand>
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        </ligand>
    </feature>
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            <end position="199"/>
        </location>
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        </location>
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        </location>
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        </location>
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        </source>
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    <sequence length="408" mass="44901" checksum="A05F104F272D2389" modified="2022-01-19" version="1">MKPARLLLLLSGCALLLAPAVRGCGPGRVVGSRRRPPRKLIPLAYKQFSPNVPEKTLGASGRYEGKIARNSERFKELTPNYNPDIIFKDEENTGADRLMTQRCKDRLNSLAISVMNQWPGVKLRVTEGWDEDGHHSEESLHYEGRAVDITTSDRDRHKYGMLARLAVEAGFDWVYYESKAHIHCSVKSEHSAAAKTGGCFPGRALATLENGARTPLWALRPGQRVLAMDGAGRPTYSDFLAFLDKEPRALTAFHVIETQQPPRRLALTPTHLLFVADNASAPAAQFRPTFASHVQPGHFVLVAVGSGELQPAKVVGVRGRMDVGAYAPLTRHGTLVVDDMVASCFALVQEQQLAQMAFWPLRLYHSLLGATGVQGDGVHWYSGLLYRLGRMLLPPDSFHPLGVPQAES</sequence>
</entry>
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        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
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                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="157" mass="18049" checksum="96469798DC0DFFE7" modified="2022-01-19" version="1">MVAAIEKKIREAFQMFDREGNETMDVREIGALVRSLGCFPTEAELRKLLAEVEEEEPTGYINLGKFLPVMTKVLLNRSFRPIPEDVLLHAFEALDENKNGYITKEELVKHMTEEGEPFTEEEMEEMLSSAIDPKTDAVHYRDYILKLLVEDADDLPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TQC3</accession>
    <name>A0A8C2TQC3_COTJA</name>
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        <submittedName>
            <fullName evidence="5">Collagen like tail subunit of asymmetric acetylcholinesterase</fullName>
        </submittedName>
    </protein>
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        <name evidence="5" type="primary">COLQ</name>
    </gene>
    <organism evidence="5 6">
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        <name type="common">Japanese quail</name>
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        <lineage>
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            <taxon>Archosauria</taxon>
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            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
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            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TQC3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005021473.1">
        <property type="protein sequence ID" value="ENSCJPP00005015118.1"/>
        <property type="gene ID" value="ENSCJPG00005012564.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157248"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031594">
        <property type="term" value="C:neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030020">
        <property type="term" value="F:extracellular matrix structural constituent conferring tensile strength"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:establishment of protein localization to membrane"/>
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        <property type="term" value="P:extracellular matrix organization"/>
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        <property type="term" value="P:regulation of synaptic assembly at neuromuscular junction"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:skeletal muscle acetylcholine-gated channel clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
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    <dbReference type="InterPro" id="IPR050149">
        <property type="entry name" value="Collagen_superfamily"/>
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        <property type="entry name" value="Myxo_disulph_rpt"/>
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    <dbReference type="NCBIfam" id="TIGR02232">
        <property type="entry name" value="myxo_disulf_rpt"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR24023:SF861">
        <property type="entry name" value="ACETYLCHOLINESTERASE COLLAGENIC TAIL PEPTIDE"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="COLLAGEN ALPHA"/>
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        <property type="entry name" value="Collagen"/>
        <property type="match status" value="2"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="37"/>
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        <location>
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        <location>
            <begin position="97"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015118.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="298" mass="32004" checksum="FDD01BEAED104F4C" modified="2022-01-19" version="1">MPGPIGWPGPVGLKGEKGDLGVMGLPGTRGPMGSKGSRGDRGDKGVKGDQVLFQMGEMGPKGQSGAPGHRGPIGRPGKRGKQGQKGDIGPVGIMGPPGRPGPSGQPGPPGPSGLGQFAIGPKGERGLPGPPGRCHCRPPQHVNNPPYEESVFGHRYPKVPAIFVVNNQEELDRLHTENALAFRRDQRSLYFKDTFGWLPVQLTPFYPVDYRIEVGSTCGDGIVQDGEECDDGNTVVTDDCIRCRRAYCGDGYKHEGVEDCDGKDFGYLTCKTYLPGSYGKLRCTSYCYIDSTQCRYFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TQF3</accession>
    <name>A0A8C2TQF3_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Inositol 1,4,5-trisphosphate receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">ITPR2</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="19">Inositol 1,4,5-trisphosphate-gated calcium channel that upon inositol 1,4,5-trisphosphate binding transports calcium from the endoplasmic reticulum lumen to cytoplasm. Exists in two states; a long-lived closed state where the channel is essentially 'parked' with only very rare visits to an open state and that ligands facilitate the transition from the 'parked' state into a 'drive' mode represented by periods of bursting activity.</text>
    </comment>
    <comment type="function">
        <text evidence="21">Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="20">Homotetramer. Interacts with CABP1. Interacts with BOK; regulates ITPR2 expression. Interacts with BCL2L10. Interacts with TRPC4. Interacts with CHGA and CHGB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Secretory vesicle membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 21">Endoplasmic reticulum membrane</location>
            <topology evidence="1 21">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="21">The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 21">Belongs to the InsP3 receptor family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSCJPT00005022309.1">
        <property type="protein sequence ID" value="ENSCJPP00005015795.1"/>
        <property type="gene ID" value="ENSCJPG00005003455.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156039"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033017">
        <property type="term" value="C:sarcoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030658">
        <property type="term" value="C:transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070679">
        <property type="term" value="F:inositol 1,4,5 trisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005220">
        <property type="term" value="F:inositol 1,4,5-trisphosphate-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097110">
        <property type="term" value="F:scaffold protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044325">
        <property type="term" value="F:transmembrane transporter binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071320">
        <property type="term" value="P:cellular response to cAMP"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071361">
        <property type="term" value="P:cellular response to ethanol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001666">
        <property type="term" value="P:response to hypoxia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd23288">
        <property type="entry name" value="beta-trefoil_MIR_ITPR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000002">
        <property type="entry name" value="Inositol 1,4,5-trisphosphate receptor type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000005">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.30:FF:000001">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.30">
        <property type="entry name" value="IP3 receptor type 1 binding core, RIH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014821">
        <property type="entry name" value="Ins145_P3_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000493">
        <property type="entry name" value="InsP3_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
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        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013662">
        <property type="entry name" value="RIH_assoc-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000699">
        <property type="entry name" value="RIH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015925">
        <property type="entry name" value="Ryanodine_IP3_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035910">
        <property type="entry name" value="RyR/IP3R_RIH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45816:SF3">
        <property type="entry name" value="INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45816">
        <property type="entry name" value="MIR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ins145_P3_rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08454">
        <property type="entry name" value="RIH_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01365">
        <property type="entry name" value="RYDR_ITPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00779">
        <property type="entry name" value="INSP3RECEPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100909">
        <property type="entry name" value="IP3 receptor type 1 binding core, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 21" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 21" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="5 21" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="22" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="17" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="9 21" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="16 21" id="KW-0407">Ion channel</keyword>
    <keyword evidence="12 21" id="KW-0406">Ion transport</keyword>
    <keyword evidence="15 21" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="13 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="14 21" id="KW-0675">Receptor</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 21" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="2227"/>
            <end position="2249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="2261"/>
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        </location>
    </feature>
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        <location>
            <begin position="2301"/>
            <end position="2325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="2345"/>
            <end position="2373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="2394"/>
            <end position="2416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="2520"/>
            <end position="2543"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="24">
        <location>
            <begin position="112"/>
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        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="24">
        <location>
            <begin position="231"/>
            <end position="287"/>
        </location>
    </feature>
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        <location>
            <begin position="1133"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="2680"/>
            <end position="2699"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="22">
        <location>
            <begin position="2630"/>
            <end position="2678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="1133"/>
            <end position="1147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004638"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00059076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00061937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU368044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="2699" mass="307233" checksum="148042604C32F0B6" modified="2022-01-19" version="1">MSEKMSSFLYIGDIVSLYAEGSVNGFISTLGLVDDRCVVQPDAGDLANPPKKFRDCLFKVCPMNRYSAQKQYWKAKQAKQGNHTEAALLKKLQHAAELEQKQNESENRKLLGEIVKYSNVIQLLHIKSNKYLTVNKRLPALLEKNAMRVTLDAAGNEGSWFYIQPFWKLRSEGDNVVVGDKVVLMPVNAGQPLHASNIELLDNPGCKEVNAVNCNTSWKITLFMKFSSYRDDVLKGGDVVRLFHAEQEKFLTCDEYEKKQHIFLRTTLRQSATSATSSKALWEIEVVHHDPCRGGAGQWNSLFRFKHLATGNYLAAELNPHYPEGNNEGKALRDGDLPASKKKRQAGEKIMYTLVSVPHGNDIASLFELDATTLQRADCLVPRNSYVRLRHLCTNTWVTSTSIPIDTNEERPVMLKIGTCQTKEDKEAFAIVSVPLSEVRDLDFANDANKVLASTVKKLENGTITQNERRFVTKLLEDLIFFVSDVPNNGQEVLDVVITKPNRERQKLMREQNILAQIFGILKAPFKDKGEGSMLRLEDLGDQRYAPYKYMLRLCYRVLRHSQQDYRKNQEYIAKNFCVMQSQIGYDILAEDTITALLHNNRKLLEKHITAKEIETFVNLLRRNREPRFLDYLSDLCVSNTTAIPVTQELICKFMLSPGNADILIQTKLISTQMDNPLECPVISDDIDEEEVWLYWIDSNKEPHGKAIRHLAQEAKEGTKVDLEVLTYYRYQLNLFARMCLDRQYLAINQISAQLSVDLILRCMSDESLPYDLRASFCRLMLHMHVDRDPQESVVPVRYARLWTEIPTKITIHEYDSFTDSSRNEMKRKFALTMEFVEEYLKEVVNQPFPFGDKEKNKLTFEVVHLARNLIYFGFYSFSELLRLTRTLLAILDIVQVPMSSYFERLSKFQDGGNNVMRTIHGVGEMMTQMVLSRGSIFPISVPDVQPSIHPSKQAATSENEDVIVMDTKLKIIEILQFILSVRLDYRISYMLSIYKREFGENNENVDSSTTSPPDTSGIPSAIVPDIDEIAAQAETMFAGRKEKNAVQLDDEGGRTFLRVLIHLIMHDYPPLLSGALHLLFKHFSQRAEVLQAFKQVQLLVSNQDVDNYKQIKADLDQLRLTVEKSELWVEKNSNYESGEGGDNQNKGGEEPLEEPNILSPIQDGTKKPQIDSNKSNNYNIVKEILVRLSKLCVQNKKCRNQQQRLLKNMGAHLVVLDLLQIPYEKSDEKMNEVMNLAHTFLQNFCRGNPQNQVLLHKNLNLFLTPGLLEAETMRHIFMNNYLLCNEISERVVQHFVHCIETHGRHVEYLRFLQTIVKADGKYVKKCQDMVMTELINGGEDVLIFYNDRASFPVLLQMMCSERDRADESGPLAYHVTLVELLAACTEGKNVYTEIKCNSLLPLDDIVRVVTHEDCIPEVKIAYVNFVNHCYVDTEVEMKEIYASNHMWKLFENFLVDMARVCNTTTDRKHADTSLEKYVTEPVMSIVSGFFNSPFSDNSTSLQTHQPVFIQLLQSAFRIYNCTWPNPTQKASVESCIKTLAEVAKNRGIAIPVDLDSQVNTLFMKSHSNMVQRAAMGWRMSARSGPRFKEALGGPAWDYRNIIEKLQDVVSSLEQQFTPMMQAEFSVLVDVLHSPELLFPEGSDARIRCGAFMSKLINHTKKLMEKEEKLCIKILQTLREMLDKKTNFAEEGNTLRKILLYRYFKGEYGSGMNGPLSTSYSKTAQVGGGFVGQDSDKSGVSMFDIQCLLDKEGASELVIDVIVSTKNDRIFSEGILLGIALLEGGNAQTQFSTYQQLKEQKKSEKFFKVLYDRMKAAQQEIRSTVTVNTIDLGSKKKDDDSDLTISVPKKRVKDSTLHLKEGMKVQLTEASSATSKAYSVYRREMDPEIDLMGAGTDATNAEEKSTEEAVMSPAIAIMQPILRFLQLLCENHNRELQNFLRHQNNKTNYNLVCETLQFLDCICGSTTGGLGLLGLYINERNVALVNQTLESLTEYCQGPCHENQTCIATHESNGIDIIIALILNDINPLGKYCMDLVLQLKNNASKLLLAIMESRQDSENAERILFNMRPKELVDVMKNAYNQGLECDHEEENGDDGISPKDVGHNIYILAHQLARHNKTLQQMLKPGSDPDEGDEALSYYANHTAQIEIVRHDRTMEQIVFPVPNICEFLTRESKSRVFNTTERDEQGSKVNDFFQQTEDLYNEMKWQKKIRNNPLLFWFSRHISLWGSISFNLAVFINLAVALFYPFGDDGDEGTLPPLISVLLWIAVALCTAMLFFISKPVGIRPFLVSVILRSIYTIGLGPTLILLGAANLCNKIVFLVSFVGNRGTFTRGYRAVVMDMAFLYHVAYVLVCMLGLCVHEFFYSFLLFDLVYREETLLNVIKSVTRNGRSIILTAVLALILVYLFSIIGFLFLKDDFIMEVDRLKIRTPVAGIGEVPTTTLTSMMGACAKENCSESIPIINSGEEEEDGIERTCDTLLMCIVTVLNQGLRNGGGVGDVLRKPSKDEPLFAARVVYDLLFYFIVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVSFEEHIKAEHNMWHYLYFIVLVKVKDSTEYTGPESYVAQMIVEKNLDWFPRMRAMSLVSNEGDSEQNEIRNLQERLESTMSLVKQLSSQLAELKEQMTEQRKNKQRLGFLGSNTPHVNHHMPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TQM2</accession>
    <name>A0A8C2TQM2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cyclin-dependent kinase 5 activator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">CDK5R2</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="8">Heterodimer of a catalytic subunit and a regulatory subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Lipid-anchor</topology>
            <orientation evidence="7">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cyclin-dependent kinase 5 activator family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015724722.1">
        <property type="nucleotide sequence ID" value="XM_015869236.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TQM2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005022431.1">
        <property type="protein sequence ID" value="ENSCJPP00005015879.1"/>
        <property type="gene ID" value="ENSCJPG00005013110.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107317035"/>
    <dbReference type="KEGG" id="cjo:107317035"/>
    <dbReference type="CTD" id="8941"/>
    <dbReference type="GeneTree" id="ENSGT00390000008812"/>
    <dbReference type="OrthoDB" id="7676799at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030426">
        <property type="term" value="C:growth cone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016533">
        <property type="term" value="C:protein kinase 5 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061575">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021549">
        <property type="term" value="P:cerebellum development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021819">
        <property type="term" value="P:layer formation in cerebral cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001764">
        <property type="term" value="P:neuron migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045956">
        <property type="term" value="P:positive regulation of calcium ion-dependent exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051493">
        <property type="term" value="P:regulation of cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021722">
        <property type="term" value="P:superior olivary nucleus maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000025">
        <property type="entry name" value="Cyclin-dependent kinase 5 activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004944">
        <property type="entry name" value="CDK5_activator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23401">
        <property type="entry name" value="CYCLIN DEPENDANT KINASE-5 ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23401:SF3">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 5 ACTIVATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03261">
        <property type="entry name" value="CDK5_activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009324">
        <property type="entry name" value="Cdk5_activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="58"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR009324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="316" mass="33872" checksum="431B8AD2C13F55B6" modified="2022-01-19" version="1">MGTVLSLSPAASSGKGGGGGGGLLADKAPGRLPGKGESRLKRPGVLISALTWKRLVAASAKKKKSTKKVTPKPGGVPPPGAQPDPLVVQRNRENLRKSLGGPSDGAKQGPLAVPVPTVPSAPQELHPGSGGGKPPPPPGSRAPGSPRRVVVQASTGELLRCLGDFVCRRCYRLKELSPGELISWFRSVDRSLLLQGWQDQGFITPANLVFVYLLCREALRGEDIGSQAELQAAFLTCLYLAYSYMGNEISYPLKPFLVEGDKGRFWERCLGIIQRLSSKMLRINADPHYFTQLFQDLKSEGEGGDGSKHWTISLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TRL9</accession>
    <name>A0A8C2TRL9_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">NGFI-A binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">NAB1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">Homomultimers may associate with EGR1 bound to DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAB family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015723365.1">
        <property type="nucleotide sequence ID" value="XM_015867879.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TRL9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005023509.1">
        <property type="protein sequence ID" value="ENSCJPP00005016787.1"/>
        <property type="gene ID" value="ENSCJPG00005013769.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107316432"/>
    <dbReference type="CTD" id="4664"/>
    <dbReference type="GeneTree" id="ENSGT00390000006330"/>
    <dbReference type="OrthoDB" id="10028556at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001958">
        <property type="term" value="P:endochondral ossification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042552">
        <property type="term" value="P:myelination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045682">
        <property type="term" value="P:regulation of epidermis development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014037">
        <property type="term" value="P:Schwann cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.2010:FF:000001">
        <property type="entry name" value="NGFI-A-binding protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.2010">
        <property type="entry name" value="NAB conserved domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006986">
        <property type="entry name" value="Nab1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006989">
        <property type="entry name" value="NAB_co-repressor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039040">
        <property type="entry name" value="NAB_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006988">
        <property type="entry name" value="Nab_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038398">
        <property type="entry name" value="NCD2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12623">
        <property type="entry name" value="NGFI-A BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12623:SF9">
        <property type="entry name" value="NGFI-A-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04902">
        <property type="entry name" value="Nab1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04905">
        <property type="entry name" value="NCD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04904">
        <property type="entry name" value="SAM_NCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Nab N-terminal" evidence="10">
        <location>
            <begin position="6"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="NAB co-repressor" evidence="11">
        <location>
            <begin position="191"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Nab1 C-terminal" evidence="9">
        <location>
            <begin position="322"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="157"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005016787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="499" mass="55608" checksum="C4FB5D44798EE892" modified="2022-01-19" version="1">MASALPRTLGELQLYRILQKANLLFYFDAFIQQGGDDVQQLCEAGEEEFLEIMALVGMASKPLHVRRLQKALRDWVTNPGLFNQPLTSLPVSSIPIYKLPEGSPAWLGISCNSYERNSATREPHLKIPKCAATTCVQSVGASKSDVVGSLSLQSSSEPRLWQGHHTTESEHSLSPADLGSPASPKENSETLDAAAALSVAECVERMVPSLPKSDLNEVKELLKTNKKLAKMIGHIFEMSDEDPHKEEEIRKYSAIYGRFDSKRKDGKHLTLHELTVNEAAAQLCVKDNALLTRRDELFALARQISREVTYKYTYRTTKSKCGERDELSPKRIKIEDGYPDFQDAVQSLYQPDKMPLALAKGKSEDLAALNSQSEKVMAKQMEFLCNQAGLERRLSTGCYRQNSEEHSPNGMSLDNVDGQGERPLNLRMSNLPSRQLQHIALDGEQHVGKPLCSELIRLYPGGEAKSQSSEGLGILKDFPHSAFNNIERKVIKTEPEDTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TRU3</accession>
    <name>A0A8C2TRU3_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acyl-coenzyme A thioesterase 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC107314827</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the C/M/P thioester hydrolase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TRU3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005024739.1">
        <property type="protein sequence ID" value="ENSCJPP00005017767.1"/>
        <property type="gene ID" value="ENSCJPG00005014457.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01010000222336"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2240:FF:000001">
        <property type="entry name" value="acyl-coenzyme A thioesterase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000024">
        <property type="entry name" value="acyl-coenzyme A thioesterase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2240">
        <property type="entry name" value="Acyl-CoA thioester hydrolase/BAAT N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016662">
        <property type="entry name" value="Acyl-CoA_thioEstase_long-chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014940">
        <property type="entry name" value="BAAT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006862">
        <property type="entry name" value="Thio_Ohase/aa_AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042490">
        <property type="entry name" value="Thio_Ohase/BAAT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10824:SF38">
        <property type="entry name" value="ACOT1 THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10824">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08840">
        <property type="entry name" value="BAAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04775">
        <property type="entry name" value="Bile_Hydr_Trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016521">
        <property type="entry name" value="Acyl-CoA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase" evidence="4">
        <location>
            <begin position="44"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="BAAT/Acyl-CoA thioester hydrolase C-terminal" evidence="5">
        <location>
            <begin position="231"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="354"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR016521-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005017767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="447" mass="49145" checksum="32A0238AB060D84C" modified="2022-01-19" version="1">VLQSVCALKISLESLQKAAGSSPLPRSPMAVQVTVLPSRRCLFDDPVQIRVTGLVPQQAVTLRACLLDEGGELFQAHAHYRAGDSGELDLTSCPALGGSYSGVEPMGLLWSLRSKTPHKRLAKRNVMTPFCVDLEVYEGHGDMSQLLGKCTHERYFLGEGVKRISVREGRLKATLFLPPGPGPFPGLIDLYGSGGGLVEYRASLLASRGFVTLALAYMAFEDLPAMPEILELDYFQEAIDFLQKQQQVKDSGIGVLGLSKGADLALSMATFLPGIKAAVSISGSGFNSFIPLRGDGFTIPAHPYDLGRVKTSEESGLIDFSDILDDHRDPATWDSRIPVEKSLAKFLFLTGLDDKNWKSDLYCRDAVQRLHQSGRKVEFCSYSGAGHLLEPPYLPLCQSSIHKVLGAFVQWGGQWREHARAQEDAWHRIQAFFWKHLMNSDIPKSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TSR9</accession>
    <name>A0A8C2TSR9_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">BRCA1 associated RING domain 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BARD1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015723478.1">
        <property type="nucleotide sequence ID" value="XM_015867992.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TSR9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005023934.1">
        <property type="protein sequence ID" value="ENSCJPP00005017132.1"/>
        <property type="gene ID" value="ENSCJPG00005014019.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107316478"/>
    <dbReference type="KEGG" id="cjo:107316478"/>
    <dbReference type="CTD" id="580"/>
    <dbReference type="GeneTree" id="ENSGT00940000156532"/>
    <dbReference type="OrthoDB" id="2384350at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070531">
        <property type="term" value="C:BRCA1-A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070532">
        <property type="term" value="C:BRCA1-B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031436">
        <property type="term" value="C:BRCA1-BARD1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070533">
        <property type="term" value="C:BRCA1-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036464">
        <property type="term" value="C:cytoplasmic ribonucleoprotein granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071479">
        <property type="term" value="P:cellular response to ionizing radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046826">
        <property type="term" value="P:negative regulation of protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085020">
        <property type="term" value="P:protein K6-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd17734">
        <property type="entry name" value="BRCT_Bard1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17720">
        <property type="entry name" value="BRCT_Bard1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16496">
        <property type="entry name" value="RING-HC_BARD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000019">
        <property type="entry name" value="BRCA1 associated RING domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039503">
        <property type="entry name" value="BARD1_Znf-RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF8">
        <property type="entry name" value="BRCA1-ASSOCIATED RING DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14835">
        <property type="entry name" value="zf-RING_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="45"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="426"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="459"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="492"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="10">
        <location>
            <begin position="570"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="10">
        <location>
            <begin position="665"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="176"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="246"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="186"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="339"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="404"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005017132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="774" mass="85301" checksum="109C3AA4A2369458" modified="2022-01-19" version="1">MREVLRGRSGNRPEPGGHSGSTAPMARCWAHTRAALEGLERALSCSRCAGVLREPVSLGGCEHVFCLSCVDDYIGKGCPVCHVPAWVQDVQVNRQLDDMVQLCSKLRHLLGSGTSDSMESTATPMCSDIGGNSNKEHIKMWFSPRSRKIRCIMNKNQIKTSSNDLCQDPSSVYHFFPSPVDEKPSKPTKKPTQRQSKKMKKKRLADINRVWCLEKPEQKGGVQEKTSKEKSVTICSEPVVLCTPEASNPKEALPQESTQEADSTKNLEEVEVSPEVKPSEEEDNDEAVCPVQVSKDKNCAAEKLPSIESEAMPLKRGREQSELPGTSQFKRQRGEGRLNGSSDSQTCSEDLSQDRPIPQVTEPKTPVQVCGSVMKTRSSAARSSPSLPETPSTPSTFKACNQAGIPQSPSVFRSPGSNPIARRNYKGETLLHLASIKGDLAAVEELLKNGADPNIKDNAGWTPLHEACNHGHQEVVELLLQHKALVNSTGYQNDSPLHDAAKNGHVSIVELLLLHGASRDAVNIFGLRPVDYAESEKMKSVLMLPVKNESFSFSQLSESPSQPRDGPIGILGSSLSSKQQKLLSRLATVLKARRCTEFNSTVTHVVIPDIPMPSTVKCMMAVLTGCWVLKFEWVQACLQSTVREQEEKYEIQGGPQRGRLNKEQLLPKLFDGCYFYFLGSFASHQKSDLVELVKAGGGQILVRQPKPDSDVTQTINTVAYHAESTSDQRFCTQYVVYDASSKFKPKKIRQGKVWFAPSSWIVDCIMSFQLLPVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TV99</accession>
    <name>A0A8C2TV99_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Proline dehydrogenase</fullName>
            <ecNumber evidence="14">1.5.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC107321433</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13 14">Converts proline to delta-1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23784"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.5.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the proline oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.2" evidence="14"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2TV99"/>
    <dbReference type="Ensembl" id="ENSCJPT00005025337.1">
        <property type="protein sequence ID" value="ENSCJPP00005018200.1"/>
        <property type="gene ID" value="ENSCJPG00005014602.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000006265"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.220:FF:000006">
        <property type="entry name" value="Proline dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002872">
        <property type="entry name" value="Proline_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015659">
        <property type="entry name" value="Proline_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914:SF0">
        <property type="entry name" value="PROLINE DEHYDROGENASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914">
        <property type="entry name" value="PROLINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01619">
        <property type="entry name" value="Pro_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6 14" id="KW-0274">FAD</keyword>
    <keyword evidence="5 14" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10 14" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Proline dehydrogenase" evidence="16">
        <location>
            <begin position="291"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="14"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="155"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU364054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005018200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="602" mass="68131" checksum="1DB06ACC59E9302E" modified="2022-01-19" version="1">MALPSAVRALHATAARVGAPRSVPRGAAPPLPASGKGGTRPVPSSVPPRDATPTVNFGDPEEAFRSKSSAELLRGLLVLGMCAVGPLVEHNRELLQLGKRVLGQALFERLMKMTFYGQFVAGEDQEAIKPLIRRNRAFGVGAVLDYSVEEDLSPATAERHELDSCTSAAEKEPGGAERREKQFRAHRGFGDRRDGVISARTYFYADEAKCDQHMETFLRCIDASSGSSEDGFSAIKLTALGRPQFLLQFSEVLVKWRRFFHQMAAEQGQGGRAALEMRLEVEKLQESLAKLGIATKAESQHWFTGENVGESGTVDLLDWNSLIDSRTKLSKLLLVPNIKTRQLEPLLSHFTEEEELQMKRMLQRMDVLAKVATETGVRLMVDAEQSYFQPAISRLSLEMQRRFNRERAIIFNTHQCYLKEAYDNVSVDVELSRREGWHFGTKLVRGAYMEQERERAAKIGYEDPINPTYEKTNEMYHRCLDYVLEEIKHSRKANVMVATHNENTVKFTLRRMMELGIHPSEKKVCFGQLLGMCDQITFPLGQAGFPVYKYVPYGPVDEVLPYLSRRAQENRGFMQRANQERDLLWREFKRRLFAGTIFSSNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TVB3</accession>
    <name>A0A8C2TVB3_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Complex III subunit 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">UQCR10</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The complex plays an important role in the uptake of multiple carbon sources present in different host niches.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)). Interacts with STMP1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the UQCR10/QCR9 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TVB3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005026687.1">
        <property type="protein sequence ID" value="ENSCJPP00005019232.1"/>
        <property type="gene ID" value="ENSCJPG00005015635.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000014052"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.260:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.260">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008027">
        <property type="entry name" value="QCR9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036656">
        <property type="entry name" value="QCR9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12980:SF0">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12980">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX, SUBUNIT X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05365">
        <property type="entry name" value="UCR_UQCRX_QCR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81514">
        <property type="entry name" value="Subunit X (non-heme 7 kDa protein) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00064262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005019232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="64" mass="7341" checksum="AC9BED49A7E1B780" modified="2022-01-19" version="1">MVMALLRQAYSALFRRTSTFALTVVLGAVLFERAFDQGADAIFEHLNEGKLWKHIKHKYEASQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TWC1</accession>
    <name>A0A8C2TWC1_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">SPARC related modular calcium binding 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">SMOC1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
            <location evidence="1">Basement membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015720202.1">
        <property type="nucleotide sequence ID" value="XM_015864716.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TWC1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005025631.1">
        <property type="protein sequence ID" value="ENSCJPP00005018401.1"/>
        <property type="gene ID" value="ENSCJPG00005014985.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107314904"/>
    <dbReference type="CTD" id="64093"/>
    <dbReference type="GeneTree" id="ENSGT00390000018436"/>
    <dbReference type="OrthoDB" id="5986054at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050840">
        <property type="term" value="F:extracellular matrix binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001654">
        <property type="term" value="P:eye development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060173">
        <property type="term" value="P:limb development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045667">
        <property type="term" value="P:regulation of osteoblast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd16240">
        <property type="entry name" value="EFh_SPARC_SMOC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00104">
        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00191">
        <property type="entry name" value="TY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000076">
        <property type="entry name" value="SPARC-related modular calcium binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.30:FF:000012">
        <property type="entry name" value="SPARC-related modular calcium binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.800.10:FF:000004">
        <property type="entry name" value="SPARC-related modular calcium-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.800.10:FF:000003">
        <property type="entry name" value="SPARC-related modular calcium-binding protein 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.10">
        <property type="entry name" value="Thyroglobulin type-1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051950">
        <property type="entry name" value="Dev_reg/Prot_inhib"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037639">
        <property type="entry name" value="SMOC1_EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019577">
        <property type="entry name" value="SPARC/Testican_Ca-bd-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000716">
        <property type="entry name" value="Thyroglobulin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036857">
        <property type="entry name" value="Thyroglobulin_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12352">
        <property type="entry name" value="SECRETED MODULAR CALCIUM-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12352:SF13">
        <property type="entry name" value="SPARC-RELATED MODULAR CALCIUM-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10591">
        <property type="entry name" value="SPARC_Ca_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16597">
        <property type="entry name" value="Thyroglob_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00086">
        <property type="entry name" value="Thyroglobulin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00211">
        <property type="entry name" value="TY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57610">
        <property type="entry name" value="Thyroglobulin type-1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00484">
        <property type="entry name" value="THYROGLOBULIN_1_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51162">
        <property type="entry name" value="THYROGLOBULIN_1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0084">Basement membrane</keyword>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034640404" evidence="13">
        <location>
            <begin position="29"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="15">
        <location>
            <begin position="41"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="14">
        <location>
            <begin position="96"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="14">
        <location>
            <begin position="228"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="154"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="133"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="266"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005018401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="457" mass="50443" checksum="F7DE058764A47B1D" modified="2022-01-19" version="1">MPPRAWRGAGARPFLLALLLAHLPQGGGHRAAGPRFLISDRDRDPQCNLHCSRSQSKPLCASDGRTYESMCDYQRAKCREPSLSVTHRGRCKDAGQSKCRLERAQALEQAKKPQEAVFIPECNEDGSFTQVQCHTYTGYCWCVTPDGKPISGSSVQNKTPVCSGSVTDKPSSQGNSGRKDDGSKPTPTMETQPIFDGEEITAPTLWIKHLVIKDSKLNSSSIRNSEKVHSCDQERQSALEEARQNPREGIVIPECAPGGLYKPVQCHQSTGYCWCVLVDTGRPLPGTSTRYETPVCESDARSKSTEIDDPFKDRELPGCPDGKKVEFITSLLDALTTDMVQAINSAAPTGGGRFSEPDPSHTLEERVVHWYFSQLDNNSSNDINKRELKPFKRYVKKKAKPKKCARRFTDYCDLNKDKSISLQELKGCLGVSKEGGSLSSFPSGKRQGLNPFIGRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TXT7</accession>
    <name>A0A8C2TXT7_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Extracellular matrix protein 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TXT7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005025769.1">
        <property type="protein sequence ID" value="ENSCJPP00005018531.1"/>
        <property type="gene ID" value="ENSCJPG00005015090.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000006215"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030500">
        <property type="term" value="P:regulation of bone mineralization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008605">
        <property type="entry name" value="ECM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020858">
        <property type="entry name" value="Serum_albumin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16776">
        <property type="entry name" value="EXTRACELLULAR MATRIX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16776:SF3">
        <property type="entry name" value="EXTRACELLULAR MATRIX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05782">
        <property type="entry name" value="ECM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48552">
        <property type="entry name" value="Serum albumin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005018531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="603" mass="65661" checksum="87778EB8B8F2F12F" modified="2022-01-19" version="1">MRPRTAPALHKAAEPPAAPQRPTPWPPSASSSSSSAPPVSSPLLSSPLNPLQPLGHNSAPLGPSCMPGPLPVHLGHHPTIFPPRCGSLPWLLVSLLWPLVSLPWPLMSLPCFLGHLGPLPTHLGPLPTFCIPIPAETTQSLLSPLWVLSVPVGSLGSLLDTSCPPPHVPELFPGCFTTTCVPSQPPLSCPCHSLPCTPNIWGFWVPICPPSSALGQGEGRVFVGSEPGVNIVLSVPCVTVANLNPQHEQLIQQSHEIQQLQQEEDFHLSPNIIASAGADDIPYPRAPSPTSTWGSILEGFPPAWPLPDALSRYCRSPSLVPRAPRPSLPPASFAHLRRQVAALDSFWPRLDRCCQHHAPLPCARRAWTDVLDTFCEDEFGVKTRQFHCCHRHGAARRRCFVDATVSTTEITEITEITVFEPVLVPSFPPGEPNVANMENICLLRGLRPSPKGLPAPRARFHSRLERDFGRCCHNSSLECAHTAWLRGLERFCREEGAVKTRQHRCCRRGVGYARSRCFATSAPHPDYDQELHNISLARPGPAMLRTLCGPIRLLSKRRPVPELLEAVTSTCCALPHDERSPCAEEQGQWGVEGVGMEGGVQHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TYJ0</accession>
    <name>A0A8C2TYJ0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Calcineurin B homologous protein 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Tescalcin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">TESC</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Lamellipodium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cell projection</location>
            <location evidence="4">Ruffle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Membrane</location>
            <topology evidence="5">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the calcineurin regulatory subunit family. CHP subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TYJ0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005026758.1">
        <property type="protein sequence ID" value="ENSCJPP00005019299.1"/>
        <property type="gene ID" value="ENSCJPG00005015668.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155845"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032587">
        <property type="term" value="C:ruffle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004860">
        <property type="term" value="F:protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071300">
        <property type="term" value="P:cellular response to retinoic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030854">
        <property type="term" value="P:positive regulation of granulocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045654">
        <property type="term" value="P:positive regulation of megakaryocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033628">
        <property type="term" value="P:regulation of cell adhesion mediated by integrin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052490">
        <property type="entry name" value="CHP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46823">
        <property type="entry name" value="CALCINEURIN B HOMOLOGOUS PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0966">Cell projection</keyword>
    <keyword evidence="20" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0221">Differentiation</keyword>
    <keyword evidence="16" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0519">Myristate</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-0649">Protein kinase inhibitor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="21">
        <location>
            <begin position="106"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="14"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00038164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00041032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00042981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005019299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="203" mass="23705" checksum="C0762422EDED61DB" modified="2022-01-19" version="1">MGSAQSVPPEMRALAERTEQIEKLHRRFKQLSHNRKTIRKEDFDTIPDLEFNPIRARIVHAFFDKRNLRKAPAGLAEEINFEDFLTIMSYFRPIEMDMDEERLENFRKEKLKFLFHMYDADYDGIITLQEYKNVLDELMSGNPHLEKESLRAIAEGAMLEAASVCMARTVRGWGGGGTMWKGIDIETKMHVRFLTMEAIAHCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TYT7</accession>
    <name>A0A8C2TYT7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Anaphase-promoting complex subunit CDC26</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Cell division cycle protein 26 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">CDC26</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CDC26 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015734144.1">
        <property type="nucleotide sequence ID" value="XM_015878658.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TYT7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005027444.1">
        <property type="protein sequence ID" value="ENSCJPP00005019848.1"/>
        <property type="gene ID" value="ENSCJPG00005016059.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107321604"/>
    <dbReference type="KEGG" id="cjo:107321604"/>
    <dbReference type="CTD" id="246184"/>
    <dbReference type="GeneTree" id="ENSGT00390000008457"/>
    <dbReference type="OrthoDB" id="2422341at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141198">
        <property type="term" value="P:protein branched polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070936">
        <property type="term" value="P:protein K48-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018860">
        <property type="entry name" value="APC_suCDC26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28579">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT CDC26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28579:SF1">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT CDC26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10471">
        <property type="entry name" value="ANAPC_CDC26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005019848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="84" mass="9562" checksum="34B170E792BAA37F" modified="2022-01-19" version="1">MLRRKPTRLELKLDDIEEFEGVRKDLESRKKQRDEADVAGGEEAAGIALGAEHKSREQLINDRIGYKPQHKAGVRAAHFGTFEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TZ34</accession>
    <name>A0A8C2TZ34_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD and tetratricopeptide repeats 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">WDTC1</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015739102.1">
        <property type="nucleotide sequence ID" value="XM_015883616.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TZ34"/>
    <dbReference type="Ensembl" id="ENSCJPT00005027389.1">
        <property type="protein sequence ID" value="ENSCJPP00005019809.1"/>
        <property type="gene ID" value="ENSCJPG00005016030.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107323989"/>
    <dbReference type="KEGG" id="cjo:107323989"/>
    <dbReference type="CTD" id="23038"/>
    <dbReference type="GeneTree" id="ENSGT00950000182900"/>
    <dbReference type="OrthoDB" id="4869960at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004857">
        <property type="term" value="F:enzyme inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042826">
        <property type="term" value="F:histone deacetylase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032869">
        <property type="term" value="P:cellular response to insulin stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055082">
        <property type="term" value="P:intracellular chemical homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035264">
        <property type="term" value="P:multicellular organism growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045717">
        <property type="term" value="P:negative regulation of fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008361">
        <property type="term" value="P:regulation of cell size"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000201">
        <property type="entry name" value="WD and tetratricopeptide repeats protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045151">
        <property type="entry name" value="DCAF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574:SF40">
        <property type="entry name" value="WD AND TETRATRICOPEPTIDE REPEATS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574">
        <property type="entry name" value="WD REPEAT DOMAIN-CONTAINING FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="63"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="106"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="560"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="590"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="670"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005019809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="691" mass="77425" checksum="45DDFA31CD68A222" modified="2022-01-19" version="1">MLGCTAALPVTSPHPPHCKRMAKANITRDIIHRQIKERGALGFERHYHVTDPFIRRLGLEAELQGHSGCVNCLEWNEKGDLLASGSDDQHTIVWDPLHHKKLLSMHTGHTANIFSVKFLPHSGDRILITGAADSKVHVHDLTVKETIHMFGDHTNRVKRIATAPMWPNTFWSAAEDGLIRQYDLRENSKRSEVLIDLTEYCGQLVEAKCLTVNPQDNNYLAVGASGPFVRLYDIRMIHNHRKSMKQCPSAGVHTFCDRQKPLPDGAAQYYVAGHLPVKLPDYNNRLRVLVATYVTFSPDGTELLVNMGGEQVYLFDLTYKQRPYTFLLPKKCHTSGEVQNGKTSTNGVSNGIHLHSNGFRLSEGRAHVSPQVELPPYLERIKQQANEAFACQLWTQAIQLYSKAVQKAPNNAMLYGNRAAAYMKRKWDGDHYDALRDCLKAISLNPCHLKAHFRLARCLFELKYVAEALECLDDFKGKFPEQAHSSACDALDRDINAALFSKSDNAEDKKGGGPIRLRATGRKDSISEDEMVLRERSYDYKFRYCGHCNTTTDIKEANFFGSNAQYIVSGSDDGSFFIWEKETTNLVRVLQGDESIVNCLQPHPSYCFLATSGIDPVVRLWNPRPESETLNGRVVVDMEGASQANQRRMNADPLEVMLLNMGYRITGLTSGGAGGSDDEDSSEGQVQCRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TZ37</accession>
    <name>A0A8C2TZ37_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Condensin complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">NCAPD2</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the CND1 (condensin subunit 1) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015728781.1">
        <property type="nucleotide sequence ID" value="XM_015873295.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005028685.1">
        <property type="protein sequence ID" value="ENSCJPP00005020829.1"/>
        <property type="gene ID" value="ENSCJPG00005016716.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107318911"/>
    <dbReference type="KEGG" id="cjo:107318911"/>
    <dbReference type="CTD" id="9918"/>
    <dbReference type="GeneTree" id="ENSGT00940000153566"/>
    <dbReference type="OrthoDB" id="436262at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000779">
        <property type="term" value="C:condensed chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010032">
        <property type="term" value="P:meiotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905821">
        <property type="term" value="P:positive regulation of chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000695">
        <property type="entry name" value="Condensin complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026971">
        <property type="entry name" value="CND1/NCAPD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032682">
        <property type="entry name" value="Cnd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007673">
        <property type="entry name" value="Condensin_cplx_su1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024324">
        <property type="entry name" value="Condensin_cplx_su1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222">
        <property type="entry name" value="CONDENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222:SF2">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12717">
        <property type="entry name" value="Cnd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12922">
        <property type="entry name" value="Cnd1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017127">
        <property type="entry name" value="Condensin_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9 14" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 14" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="10 14" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensin complex subunit 1 N-terminal" evidence="17">
        <location>
            <begin position="78"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Condensin complex subunit 1 C-terminal" evidence="16">
        <location>
            <begin position="1077"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="957"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1308"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="957"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="968"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="1353"/>
            <end position="1371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR017127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF12717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF12922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005020829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1412" mass="158166" checksum="01490242F82F26BF" modified="2022-01-19" version="1">MAAVLPAEFQLPLTADDLLRGDSSRHYVVQEVLPARELPAAITDFQAAFRERGALAVLQHFDTVYSLLRHFRALDTAAKEDALELMMQVVTHHSNELSTILSDSGLSHTDRNAHLNALKMNCYLLSGLLEAFEMEAFKSGLAEVDPAGKNKKSHAKSSGFSWEDEREPVLQLFTQLLQLDLRQLWSGLVVEEEFVSLLTGCCYRILENSNIGLQRYRATREAATHLLATALTHYDHMFSATLKITQMLQHFEHVAPLFAQAVTLWAKEYGLKSIVGELLREIGQKCPQELARDTSGIKGYAVFITELAEQIPSLVLSNMSVLLRHLDGENYMMRNAILSAMAEVLLQVLNGDQLEEAVRGTRDHFLNTLQAHICDVHGFVRSRVLQLFTRIVQGKVLPLTQFLAVVSLAVGRLKDKSVVVVKNAIQLLAAFLSNNPYSCKLSCNDLAEPLKKEVQKLQEMKDRCREPAPTISPEEEWEAMLPEVRAAARQILQPSQEEEDEEVLEVEETAERASEQIIGMLKKLNYKGAVRLTQKAVCSFQAQEPFSSFKEENEEARILGILERLYTGFCPGENSGDSPCESGSLTTEEAALEERPQEQPQTELVKQEMLVQYLQDAYNFSVKITEALSQISKLMYENSVSVVQEAIEFFVTVSQFGVPQALLGVRKMLPLVWSKEPGIREAVLNAYRQLYLSPSGNSERARAQNLVSSLYLIMVDASLGTIQCLEEIISEFVQKDEIKPAVIQLLWEQFTEKTQCSPLERRAAVMLLGMMARGKPEIIGSNLDVLVTVGLSERVCEDYRLAEEVCNAISKLASNSKPAKGKNNVPFRLPQEQELFECLSKAVSNGFTQQSSHWIPFMEAAVTLIYQLAEGPEKICAHILQVCSQKALENLQEADGQKEVESGASPNRVSDGAVSLPTFLLLHLVSLVGQVALQQVAHLEVSVNAELRRRRILREEEKTKKHKERSDSSTIKQRAQSTGNDITMEEELGLIGASADDTEAELIRSICETELLDEKHLLSAFVPLVLKICNNPGLYSDPALRAAAALALGKVCMISSEFCDSHLRLLFTMMEKSPLPVVRSNLIIAAGDLAIRFPNQVEPWTPHLYARLRDPCQSVRQTAGVVMTHLILKDMVKVKGQVSEMAALLIDPEEAIMAVAQNFFNELSHKDNAIYNLLPDMISRLSDPACGVDEESFHTIMRHLFSYITKDKQTESLVEKLCQRFRTARNERQYRDLSYCLSLLPISERGLHKLQDNFDCFADKLQDPAVYSCFQAVLVRFRRAVGKPEAKALAEELEQKLSACHNQGLDSAETCQEGGKTPMPEPAKRKTTAGSCRRPLSTANRGDDDDDFVTPRPRAHQKNKRVQKSQRRKKTVIIFSSDEENSSENELLAELREEETPTKTTPITRSSTRRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U1H5</accession>
    <name>A0A8C2U1H5_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Lysine-specific histone demethylase</fullName>
            <ecNumber evidence="21">1.14.99.66</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="primary">KDM1A</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="21">Histone demethylase that can demethylate both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20 21">
            <text>N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + 2 A + 2 H2O = L-lysyl(4)-[histone H3] + 2 formaldehyde + 2 AH2</text>
            <dbReference type="Rhea" id="RHEA:60244"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="Rhea" id="RHEA-COMP:15547"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
            <dbReference type="EC" id="1.14.99.66"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 21 22">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 21">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="21">The SWIRM domain may act as an anchor site for a histone tail.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 21">Belongs to the flavin monoamine oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.66" evidence="21"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2U1H5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005027323.1">
        <property type="protein sequence ID" value="ENSCJPP00005019753.1"/>
        <property type="gene ID" value="ENSCJPG00005015581.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157193"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990391">
        <property type="term" value="C:DNA repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035097">
        <property type="term" value="C:histone methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140682">
        <property type="term" value="F:FAD-dependent H3K4me/H3K4me3 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032454">
        <property type="term" value="F:histone H3K9 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043426">
        <property type="term" value="F:MRF binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050681">
        <property type="term" value="F:nuclear androgen receptor binding"/>
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    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
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    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
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    <keyword evidence="16 21" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="12" id="KW-0832">Ubl conjugation</keyword>
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        <location>
            <begin position="153"/>
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        </location>
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            <begin position="1"/>
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    <sequence length="831" mass="91137" checksum="9F75F2E017B5C266" modified="2022-01-19" version="1">MLAGGKKAAEAAGGEGGPEAPVPPSAAVGALGSSSESGAAAERTPRKKEPPRASPPGGASEPPAAPASGGETTGIAETPEGRRTSRRKRAKVEYREMDESLANLSEDEYYSEEERNAKAEKEKKLPPPPPPAPAEEENESEPEDRLLPEISGVEGAAFQSRLPHDRMTSQEAACFPDIISGPQQTQKVFLYIRNRTLQLWLDNPKIQLTFEATIQQLEAPYNSDTVLVHRVHSYLERHGLINFGIYKRVKPLPTKKTGKVIIIGSGVSGLAAARQLQSFGMDVTVLEARDRVGGRVATFRKGNYVADLGAMVVTGLGGNPMAVVSKQVNMELAKIKQKCPLYEANGQAVPKEKDEMVEQEFNRLLEATSYLSHQLDFNVLNNKPVSLGQALEVVIQLQEKHVKDEQIEHWKKIVKTQEELKDLLNKMVNLKEKIKELHQQYKEASEVKPPRDITAEFLVKSKHRDLTALCKEYDELAETQGKLEEKLQELEANPPSDVYLSSRDRQILDWHFANLEFANATPLSTLSLKHWDQDDDFEFTGSHLTVRNGYSCVPVALAEGLDIKLNTAVRQVRYTASGCEVIAVNTRSTSQTFIYKCDAVLCTLPLGVLKQQPPAVQFVPPLPEWKTSAVQRMGFGNLNKVVLCFDRVFWDPSVNLFGHVGSTTASRGELFLFWNLYKAPILLALVAGEAAGIMENISDDVIVGRCLAILKGIFGSSAVPQPKETVVSRWRADPWARGSYSYVAAGSSGNDYDLMAQPITPGPAIPGAPQPIPRLFFAGEHTIRNYPATVHGALLSGLREAGRIADQFLGAMYTLPRQPTPGVPTQQATSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U2R1</accession>
    <name>A0A8C2U2R1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoinositide 5-phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.36</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">INPP5B</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Phagosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Early endosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.36" evidence="4"/>
    <dbReference type="RefSeq" id="XP_015739137.1">
        <property type="nucleotide sequence ID" value="XM_015883651.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U2R1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005027986.1">
        <property type="protein sequence ID" value="ENSCJPP00005020294.1"/>
        <property type="gene ID" value="ENSCJPG00005016364.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107324005"/>
    <dbReference type="CTD" id="3633"/>
    <dbReference type="GeneTree" id="ENSGT00940000156762"/>
    <dbReference type="OrthoDB" id="7862313at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030670">
        <property type="term" value="C:phagocytic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052658">
        <property type="term" value="F:inositol-1,4,5-trisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030317">
        <property type="term" value="P:flagellated sperm motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070613">
        <property type="term" value="P:regulation of protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd09093">
        <property type="entry name" value="INPP5c_INPP5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04380">
        <property type="entry name" value="RhoGAP_OCRL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000132">
        <property type="entry name" value="Inositol polyphosphate 5-phosphatase OCRL-1 isoform b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000012">
        <property type="entry name" value="Putative inositol polyphosphate 5-phosphatase OCRL-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000004">
        <property type="entry name" value="Type II inositol 1,4,5-trisphosphate 5-phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031896">
        <property type="entry name" value="INPP5B_PH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048869">
        <property type="entry name" value="OCRL-1_2_ASH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037793">
        <property type="entry name" value="OCRL1/INPP5B_INPP5c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047078">
        <property type="entry name" value="RhoGAP_OCRL1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF300">
        <property type="entry name" value="TYPE II INOSITOL 1,4,5-TRISPHOSPHATE 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16776">
        <property type="entry name" value="INPP5B_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21310">
        <property type="entry name" value="OCRL-like_ASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="11">
        <location>
            <begin position="678"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="143"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005020294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="862" mass="98008" checksum="6AF94CE2374CA419" modified="2022-01-19" version="1">MDQSVAIQETLLDGATCRIAVQGAVAAGQSVESRLLGLVERDGQHAIYVYTHRRMAITAEDVWLEKVIPITQGFAVEEVIPDGDLHVIGSDVTIRIRSEDDGLTVQLPFGSHTRTFLQEVSKCSTEGSEGIKQNGKKLVVSPGWSQDSTDSNASRQSKLKPEVTTEMVRSSSVMVSNVASILLEPKFELRDTIVKSELVQREDSYTYIQNFRFFVGTYNVNGQSPRESLQPWLRCDSAPPDIYCVGFQELDLSKEAFFFNDTPKEEEWFKAVTDSLHPDAKYAKVKLVRLVGIMLLLYVKADLALNISEVEIETVGTGIMGRMGNKGGVAIRFKFHNTSVCVVNSHLAAHTEEYERRNQDFKDICSRMQFCQSDPNLPPLTISKHDVILWLGDLNYRLEELDVMKVKQLVDEKAFPELCKYDQLKRQMNAKAVFEGFTEGEISFQPTYKYDAGCDEWDTSEKCRVPAWCDRILWKGQNITQLSYRSHMALKISDHKPVSSVFDIGVKVVNEELYRKVFEEIVRSLDKMENANIPSVTLSQREFHFEDVKYMQLQVEKFTIRNGQVPCQFEFISKPDEDTYCKEWLIANPSKGFLLPGSEITIELELFVNKSTATRLNSGEEKLEDILVLHLTRGKDYFLSVTGNYLPSCFGSPIHTLCYMREPIQDMSAESIRNLTLMPLEASNNATQAEKPLEIPKELWMMVDHLYRNASQQEDLFQQPGLRSEFEQIRDCLDKGMHDTLLGSNHSVAEALLLFLESLPEPVICYKFYSSCLECANNYLLSSQIISNLPECHRNVFEYLMAFLRELLKNSGKNNLDVNILASIFGGLLLRPPPGHPMPDITEKRKAQQFIHQFLLRDSSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U2U0</accession>
    <name>A0A8C2U2U0_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">G protein-coupled receptor 161</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">GPR161</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015731981.1">
        <property type="nucleotide sequence ID" value="XM_015876495.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015731987.1">
        <property type="nucleotide sequence ID" value="XM_015876501.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015731997.1">
        <property type="nucleotide sequence ID" value="XM_015876511.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015732006.1">
        <property type="nucleotide sequence ID" value="XM_015876520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U2U0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005029993.1">
        <property type="protein sequence ID" value="ENSCJPP00005021894.1"/>
        <property type="gene ID" value="ENSCJPG00005017481.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005029994.1">
        <property type="protein sequence ID" value="ENSCJPP00005021895.1"/>
        <property type="gene ID" value="ENSCJPG00005017481.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107320549"/>
    <dbReference type="KEGG" id="cjo:107320549"/>
    <dbReference type="CTD" id="23432"/>
    <dbReference type="GeneTree" id="ENSGT00940000157829"/>
    <dbReference type="OrthoDB" id="5980076at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060170">
        <property type="term" value="C:ciliary membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15214">
        <property type="entry name" value="7tmA_GPR161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000091">
        <property type="entry name" value="G-protein coupled receptor 161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22752">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22752:SF10">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 14" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 14" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="184"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="16">
        <location>
            <begin position="42"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005021895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="525" mass="58027" checksum="D1F008B4A3196F55" modified="2022-01-19" version="1">MSSNSSLGNGNGLRNLTTQEDGVVRVTEAIAIIVIAVFICLGNLIIVVTLYRKSYLLTLSNKFVFSLTLSNFLLSVLVLPFVVTSSIRREWIFGVVWCNFSALLYMLISSASMLTLGLIAIDRYYAVLYPMVYPMKITGNRAVVALVYVWLHSLIGCLPPLFGWSSLEFDQFKWMCVAAWHKEAAYTAFWQVWCALLPFVVMMICYGFIFRVARIKARKIHCGSVVIVEEDSQRNGRKNSSTSTSSSGSRRNAFQGVVYSANQCKAFITILVVIGAFVITWGPYMVVITSEALWGKNSISPALETLATWLSFSSAICHPLIYGLWNKTVRKELLGMCFGDRYYRESFVQRHRTSRLFSISNRITDLGLSPHLTALMAGGRPLGNSSSTGDTGFSCSQDSGTDTMLLEDYSSDGPSLPHCVCPPRRRSSVTFEDEVEQIKGGLRETAKNSVLHVKADVHKSLDSYASSLARAIEADVKISLFGEGALPGALFPVRTLPGSGMNTRRGVRPHASQRLQLQSIDEGNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U3Z4</accession>
    <name>A0A8C2U3Z4_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Ephrin type-A receptor 3</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">EPH-like kinase 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="30" type="primary">EPHA3</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="30" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="30" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="30" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="RefSeq" id="XP_015734133.1">
        <property type="nucleotide sequence ID" value="XM_015878647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U3Z4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005030368.1">
        <property type="protein sequence ID" value="ENSCJPP00005022118.1"/>
        <property type="gene ID" value="ENSCJPG00005017690.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107321597"/>
    <dbReference type="KEGG" id="cjo:107321597"/>
    <dbReference type="CTD" id="2042"/>
    <dbReference type="GeneTree" id="ENSGT00940000157088"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005004">
        <property type="term" value="F:GPI-linked ephrin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005005">
        <property type="term" value="F:transmembrane-ephrin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071300">
        <property type="term" value="P:cellular response to retinoic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045806">
        <property type="term" value="P:negative regulation of endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010976">
        <property type="term" value="P:positive regulation of neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903078">
        <property type="term" value="P:positive regulation of protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032956">
        <property type="term" value="P:regulation of actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051893">
        <property type="term" value="P:regulation of focal adhesion assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070507">
        <property type="term" value="P:regulation of microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd10481">
        <property type="entry name" value="EphR_LBD_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd05066">
        <property type="entry name" value="PTKc_EphR_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09544">
        <property type="entry name" value="SAM_EPH-A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000046">
        <property type="entry name" value="ephrin type-A receptor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000041">
        <property type="entry name" value="ephrin type-A receptor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000019">
        <property type="entry name" value="Ephrin type-A receptor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.10:FF:000001">
        <property type="entry name" value="Ephrin type-A receptor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000045">
        <property type="entry name" value="Ephrin type-A receptor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1770:FF:000001">
        <property type="entry name" value="Ephrin type-A receptor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000001">
        <property type="entry name" value="Ephrin type-A receptor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000001">
        <property type="entry name" value="Ephrin type-A receptor 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1770">
        <property type="entry name" value="ephrin a2 ectodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027936">
        <property type="entry name" value="Eph_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034266">
        <property type="entry name" value="EphA3_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001090">
        <property type="entry name" value="Ephrin_rcpt_lig-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050449">
        <property type="entry name" value="Ephrin_rcpt_TKs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011641">
        <property type="entry name" value="Tyr-kin_ephrin_A/B_rcpt-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016257">
        <property type="entry name" value="Tyr_kinase_ephrin_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001426">
        <property type="entry name" value="Tyr_kinase_rcpt_V_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46877">
        <property type="entry name" value="EPH RECEPTOR A5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46877:SF12">
        <property type="entry name" value="EPHRIN TYPE-A RECEPTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14575">
        <property type="entry name" value="EphA2_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25599">
        <property type="entry name" value="Ephrin_CRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01404">
        <property type="entry name" value="Ephrin_lbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07699">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000666">
        <property type="entry name" value="TyrPK_ephrin_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00014">
        <property type="entry name" value="FNTYPEIII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00615">
        <property type="entry name" value="EPH_lbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01411">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51550">
        <property type="entry name" value="EPH_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00790">
        <property type="entry name" value="RECEPTOR_TYR_KIN_V_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00791">
        <property type="entry name" value="RECEPTOR_TYR_KIN_V_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 21 23" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="22" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 21 23" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-0675">Receptor</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 25" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 24" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="14" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="signal peptide" evidence="25">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034264584" description="Ephrin type-A receptor 3" evidence="25">
        <location>
            <begin position="24"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="541"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="Eph LBD" evidence="29">
        <location>
            <begin position="28"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="28">
        <location>
            <begin position="324"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="28">
        <location>
            <begin position="435"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="26">
        <location>
            <begin position="621"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="27">
        <location>
            <begin position="911"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="20">
        <location>
            <position position="746"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <begin position="627"/>
            <end position="635"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21 23">
        <location>
            <position position="653"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="22">
        <location>
            <begin position="70"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="22">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00072205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00076437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR000666-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR000666-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR000666-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS51550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005022118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="983" mass="109765" checksum="075B3E4115AA2D17" modified="2022-01-19" version="1">MDRRRLPLLLLCAALGSAGRLSARPGNEVNLLDSKTIQGELGWISYPSHGWEEISGVDEHYTPIRTYQVCNVMDHSQNNWLRTNWIPRNSAQKIYVELKFTLRDCNSIPLVLGTCKETFNLYYMESDDDHLAKFREHQFTKIDTIAADESFTQMDLGDRILKLNTEVREVGPVSKKGFYLAFQDVGACVALVSVRVYFKKCPFTVKNLAVFPDTVPMDSQSLVEVRGSCVNHSKEEEPPKMYCSTEGEWLVPIGKCLCNAGYEERGFACQACRPGFYKASAGNVKCAKCPPHSSTYEDASLNCRCEKNYFRSEKDPPSMACTRPPSAPRNVISNINETSVILDWSWPLDTGGRKDVTFNIICKKCGGSSKICEPCSDNVRFLPRQTGLTNTTVTVVDLLAHTNYTFEIDAVNGVSDLSTLSRQFAAVSITTNQAAPSPITVIRKDRTSRNSVSLSWQEPEHPNGIILDYEVKYYEKQEQETSYTILRAKSTNVTISGLKPDTTYVFQIRARTAAGYGTSSRKFEFETSPDSFSISSENSQVVMIAISAAVAIILLTVVVYVLIGRFCGYKKSKHGNDEKRLHFGNGHLKLPGLRTYVDPHTYEDPNQAVHEFAKELDASNISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKAGYTEKQRRDFLGEASIMGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWEMSNQDVIKAVDEGYRLPPPMDCPAALYQLMLDCWQKDRNSRPKFDEIVSILDKLIRNPSSLKIITNAAARPSNLLLDQSNIDISAFRTAGDWLNGFRTGQCKGIFTGVEYSSCDTIAKISTDDMKKIGVTVVGPQKKIVSSIKTLETHTKNSPVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U4L1</accession>
    <name>A0A8C2U4L1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Claudin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">CLDN2</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell junction</location>
            <location evidence="8">Tight junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the claudin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015716045.1">
        <property type="nucleotide sequence ID" value="XM_015860559.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U4L1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005028991.1">
        <property type="protein sequence ID" value="ENSCJPP00005021075.1"/>
        <property type="gene ID" value="ENSCJPG00005016886.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107312820"/>
    <dbReference type="KEGG" id="cjo:107312820"/>
    <dbReference type="CTD" id="9075"/>
    <dbReference type="GeneTree" id="ENSGT00940000160785"/>
    <dbReference type="OrthoDB" id="9446875at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160187">
        <property type="term" value="F:paracellular tight junction channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160184">
        <property type="term" value="P:paracellular transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.150:FF:000001">
        <property type="entry name" value="Claudin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006187">
        <property type="entry name" value="Claudin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005411">
        <property type="entry name" value="Claudin2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017974">
        <property type="entry name" value="Claudin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004031">
        <property type="entry name" value="PMP22/EMP/MP20/Claudin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12002">
        <property type="entry name" value="CLAUDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00822">
        <property type="entry name" value="PMP22_Claudin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01077">
        <property type="entry name" value="CLAUDIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01589">
        <property type="entry name" value="CLAUDIN2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01346">
        <property type="entry name" value="CLAUDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0965">Cell junction</keyword>
    <keyword evidence="3 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0796">Tight junction</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="193"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="217"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU060637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005021075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="227" mass="24378" checksum="6ABE432FFEE11545" modified="2022-01-19" version="1">MVSMGLQLVGYAVAFLGYIGTLTTTLLPNWKISSYIGSSIVTAVSFTKGLWMECATYSTGITQCDIYSSLLNLPPDIQAAQALMVSSCVVSSLACLMTVMGMRCTVFNQGSPAKDRVAVAGGVVFILGGLLCFIPLVWNIHVVLRDFHNPLLPDSTKFELGEALYLGIISSLLSLIGGFILCASCPPRDPSSPYSPRLLASRSPQPSIKQMQKPKSEFSSYNLTGYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U8F1</accession>
    <name>A0A8C2U8F1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Leucine-rich glioma-inactivated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LGI1</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Synapse</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015722633.1">
        <property type="nucleotide sequence ID" value="XM_015867147.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015722635.1">
        <property type="nucleotide sequence ID" value="XM_015867149.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015722636.1">
        <property type="nucleotide sequence ID" value="XM_015867150.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032301168.1">
        <property type="nucleotide sequence ID" value="XM_032445277.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032301169.1">
        <property type="nucleotide sequence ID" value="XM_032445278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U8F1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005032903.1">
        <property type="protein sequence ID" value="ENSCJPP00005024105.1"/>
        <property type="gene ID" value="ENSCJPG00005019042.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107316060"/>
    <dbReference type="KEGG" id="cjo:107316060"/>
    <dbReference type="CTD" id="9211"/>
    <dbReference type="GeneTree" id="ENSGT00940000159793"/>
    <dbReference type="OrthoDB" id="6066926at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043083">
        <property type="term" value="C:synaptic cleft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048018">
        <property type="term" value="F:receptor ligand activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099645">
        <property type="term" value="P:neurotransmitter receptor localization to postsynaptic specialization membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030307">
        <property type="term" value="P:positive regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050806">
        <property type="term" value="P:positive regulation of synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000017">
        <property type="entry name" value="leucine-rich repeat LGI family member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
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        <property type="entry name" value="EAR"/>
    </dbReference>
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        <property type="entry name" value="EPTP"/>
    </dbReference>
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        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
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        <property type="entry name" value="LGI_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24367:SF17">
        <property type="entry name" value="LEUCINE-RICH GLIOMA-INACTIVATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24367">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03736">
        <property type="entry name" value="EPTP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
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    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="LRRCT"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0770">Synapse</keyword>
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        <location>
            <begin position="1"/>
            <end position="26"/>
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    <feature type="chain" id="PRO_5034161901" description="Leucine-rich glioma-inactivated protein 1" evidence="12">
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            <begin position="27"/>
            <end position="543"/>
        </location>
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            <begin position="165"/>
            <end position="214"/>
        </location>
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            <dbReference type="ARBA" id="ARBA00004496"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
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            <dbReference type="ARBA" id="ARBA00022490"/>
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            <dbReference type="ARBA" id="ARBA00022614"/>
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            <dbReference type="ARBA" id="ARBA00023180"/>
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            <dbReference type="SMART" id="SM00082"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="543" mass="62501" checksum="0F03AB260F625E86" modified="2022-01-19" version="1">MGNASRPFRRIAYFLCLLSVLLLTEGKKPVKPKCPAWCTCTKDNALCENARSIPRSVPPDVISLSFVRSAFTKIPEGSFLLTPSLQLLLFTSNTFDVISDDAFMGLPHLEYLFIENNSIKSISRNTFRGLKSLIHLSLANNNLQSLPKDIFKGLDSLTNVDLRGNAFNCDCKLKWLVEWLGSTNATVEDIYCESPPEYKKRKINSLSSKEFDCIITEFEVFQSLPYQSLSVDTFSYMNDEHVVIAQPFTGKCIFLEWDHVEVMFRNYDNITGTSTVVCKPIVIESQLYVIVAQLFGGSHIYKRDIFANKFIKIQDIEILKIRKPNDIETFRIAEDWYFVVADSSKAGFTTVYKWNGNGFYSHQSLHAWYRDTDVEFLEIAGKPHLILSSSSQRPVIYQWNKGTNEFVKRFDIQDMEDAYAVKHFRVKEDVYICLTRFIGDSKVMKWGGSAFLDLQRMPSRGSMVFQPLQIRNYQYAILGSDYSFTQVYYWDAEKAKFVKFQELNIQAPRSFIHVSIDKRDFLFASSFKGTTLIYKHVRVDLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U8M1</accession>
    <name>A0A8C2U8M1_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cortexin 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">CTXN2</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2U8M1"/>
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        <property type="protein sequence ID" value="ENSCJPP00005025008.1"/>
        <property type="gene ID" value="ENSCJPG00005019662.1"/>
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        <property type="component" value="Chromosome 10"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005025008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="81" mass="8888" checksum="4E810AB8A24CB227" modified="2022-01-19" version="1">MSSNYCGNTSASMSVNEMSAFPLTLEQKTGFAFVGILCVFLGLLIIRCFKILLDPYSSMPSSTWEDEVEGLDKGTFEYALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U9R0</accession>
    <name>A0A8C2U9R0_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">HtrA serine peptidase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">HTRA3</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1C family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015718386.1">
        <property type="nucleotide sequence ID" value="XM_015862900.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U9R0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005032042.1">
        <property type="protein sequence ID" value="ENSCJPP00005023384.1"/>
        <property type="gene ID" value="ENSCJPG00005018553.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107314035"/>
    <dbReference type="KEGG" id="cjo:107314035"/>
    <dbReference type="CTD" id="94031"/>
    <dbReference type="GeneTree" id="ENSGT00940000159570"/>
    <dbReference type="OrthoDB" id="4217619at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030514">
        <property type="term" value="P:negative regulation of BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030512">
        <property type="term" value="P:negative regulation of transforming growth factor beta receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06785">
        <property type="entry name" value="cpPDZ_HtrA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00104">
        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.120:FF:000002">
        <property type="entry name" value="HtrA serine peptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000867">
        <property type="entry name" value="IGFBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22939">
        <property type="entry name" value="SERINE PROTEASE FAMILY S1C HTRA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22939:SF14">
        <property type="entry name" value="SERINE PROTEASE HTRA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00219">
        <property type="entry name" value="IGFBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13365">
        <property type="entry name" value="Trypsin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00121">
        <property type="entry name" value="IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51323">
        <property type="entry name" value="IGFBP_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034475094" evidence="9">
        <location>
            <begin position="20"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="IGFBP N-terminal" evidence="11">
        <location>
            <begin position="24"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="12">
        <location>
            <begin position="74"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="10">
        <location>
            <begin position="353"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005023384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="464" mass="50097" checksum="995739D17381F084" modified="2022-01-19" version="1">MRLSLLSSLLVLCISRGFAELPAARAKCPTRCDVSKCPSPSCPSGYVPDRCNCCLICAAGEGDSCGRKEDPPCGDSLDCRYPMGKRFAKGVCQCKLSAQVCGSDGLTYDNICQLKAVSRKALQHGLPAVAQVQKGACESGHLQSSSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIMSDSGLIVTNAHVVSSTNAISGRQQLKVQLQNGDTYEATIRDIDKKSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQRDGKELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITQFLTESLDKQNKDSKKRFIGIRMLTITPALVEELKHNNADFPDVRSGIYVHEVVPNSPSHRGGIQDGDIIVKVNGRPLLTSSDLQEAVMNESPLLLEVRRGNDDLLFNIEPEIVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UB22</accession>
    <name>A0A8C2UB22_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA damage regulated autophagy modulator 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">DRAM1</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DRAM/TMEM150 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015722973.1">
        <property type="nucleotide sequence ID" value="XM_015867487.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UB22"/>
    <dbReference type="Ensembl" id="ENSCJPT00005035347.1">
        <property type="protein sequence ID" value="ENSCJPP00005026066.1"/>
        <property type="gene ID" value="ENSCJPG00005020344.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107316233"/>
    <dbReference type="KEGG" id="cjo:107316233"/>
    <dbReference type="CTD" id="55332"/>
    <dbReference type="GeneTree" id="ENSGT01030000234578"/>
    <dbReference type="OrthoDB" id="191706at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019402">
        <property type="entry name" value="CWH43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050911">
        <property type="entry name" value="DRAM/TMEM150_Autophagy_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21324:SF11">
        <property type="entry name" value="DNA DAMAGE-REGULATED AUTOPHAGY MODULATOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21324">
        <property type="entry name" value="FASTING-INDUCIBLE INTEGRAL MEMBRANE PROTEIN TM6P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10277">
        <property type="entry name" value="Frag1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="CWH43-like N-terminal" evidence="7">
        <location>
            <begin position="22"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005026066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="251" mass="27998" checksum="8B8B1041E5A9FE47" modified="2022-01-19" version="1">MWAPMPGAGRQREMLCFMPGVAAVPALLVCWSSAAFIISYVIAVLAGHVEPLVPYISDTGTKPPESGVFGFMINISALLGAITMYIRYLIIEKQNESLRFVRSSCNMFSLCIGLMGCTGMGIVATFQELSVPSVHDIGALVAFGCGVVYITLQSIISYKSCPQWNTYFVCHIRMLISVISCISFIPMIVFASRISMTKIDWTPSEKDYTYHFMSAICEWTVAFGFVFFFLTFIKDFQRVTLRISTEIHEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UBY4</accession>
    <name>A0A8C2UBY4_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">C-type mannose receptor 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Macrophage mannose receptor 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">MRC2</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015741343.1">
        <property type="nucleotide sequence ID" value="XM_015885857.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005033085.1">
        <property type="protein sequence ID" value="ENSCJPP00005024248.1"/>
        <property type="gene ID" value="ENSCJPG00005019147.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107325210"/>
    <dbReference type="KEGG" id="cjo:107325210"/>
    <dbReference type="CTD" id="9902"/>
    <dbReference type="GeneTree" id="ENSGT01050000244842"/>
    <dbReference type="OrthoDB" id="5858677at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005518">
        <property type="term" value="F:collagen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030574">
        <property type="term" value="P:collagen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23408">
        <property type="entry name" value="beta-trefoil_Ricin_MRC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="CDD" id="cd03590">
        <property type="entry name" value="CLECT_DC-SIGN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00062">
        <property type="entry name" value="FN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.100.10:FF:000026">
        <property type="entry name" value="C-type mannose receptor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.100.10:FF:000035">
        <property type="entry name" value="C-type mannose receptor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.10.10:FF:000001">
        <property type="entry name" value="Fibronectin 1a isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000035">
        <property type="entry name" value="Mannose receptor C type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.100.10:FF:000019">
        <property type="entry name" value="Mannose receptor C type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.100.10:FF:000020">
        <property type="entry name" value="Mannose receptor C type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.100.10:FF:000021">
        <property type="entry name" value="Mannose receptor C type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.100.10:FF:000029">
        <property type="entry name" value="Mannose receptor C type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.100.10:FF:000033">
        <property type="entry name" value="Mannose receptor C type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.100.10:FF:000018">
        <property type="entry name" value="Mannose receptor, C type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.10.10">
        <property type="entry name" value="Fibronectin, type II, collagen-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033989">
        <property type="entry name" value="CD209-like_CTLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000562">
        <property type="entry name" value="FN_type2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036943">
        <property type="entry name" value="FN_type2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013806">
        <property type="entry name" value="Kringle-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24562">
        <property type="entry name" value="CysR_MRC2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00040">
        <property type="entry name" value="fn2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00013">
        <property type="entry name" value="FNTYPEII"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00059">
        <property type="entry name" value="FN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57440">
        <property type="entry name" value="Kringle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00023">
        <property type="entry name" value="FN2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51092">
        <property type="entry name" value="FN2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="13 18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="7" id="KW-0430">Lectin</keyword>
    <keyword evidence="12 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-0675">Receptor</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 21" id="KW-0732">Signal</keyword>
    <keyword evidence="5 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034811562" description="C-type mannose receptor 2" evidence="21">
        <location>
            <begin position="33"/>
            <end position="1476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1411"/>
            <end position="1433"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-II" evidence="23">
        <location>
            <begin position="178"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="22">
        <location>
            <begin position="240"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="22">
        <location>
            <begin position="385"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="22">
        <location>
            <begin position="524"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="22">
        <location>
            <begin position="674"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="22">
        <location>
            <begin position="828"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="22">
        <location>
            <begin position="976"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="22">
        <location>
            <begin position="1129"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="22">
        <location>
            <begin position="1270"/>
            <end position="1381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1443"/>
            <end position="1476"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="183"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="197"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00070538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00082299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005024248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1476" mass="167401" checksum="3FFB1975B02D0F3C" modified="2022-01-19" version="1">MGSPAGLRPLLCPLYPLCPRLLLLLALHPMLSAPHPDSKVFLIYNVGAQGCLETKDSLVRLAKGCNASSPAHQWKWVSRNRLFNVGAMQCLGVSWHGGNATSGLHPLATYECDRESINMRWSCRGLGEQLSQHLGARPNNTSLDRGDQARSSQWRTYGTEEDLCSVPYSEIYTIQGNSHGKPCTIPFKYDNQWFHECTSTGREDGHLWCATTQDYGKDERWGFCPIKSNDCETFWDKDHLTNSCYQFNFQSTLSWREAWNSCEQQGANLLSITEIHEQTYINGLLTGYSSTLWIGLNDLDINGGWQWSDNSPLKYLNWESDQPDNPSEENCGVIRTESSGGWQNRDCGIALPYVCKKKPNATTDPFLTDSWSEVKVDCEPSWLSFQSNCYRLVGEKKSWQDAKKTCLRSGGDLVSIHTLSELEFVTKQVKQDVEELWIGLNDLKLQMNFEWSDGTPVRFTYWHPFEPNNFRDSLEDCVTIWGPEGRWNDSPCNQSLPSICKKPGQVSQEKEEDDHGCRKGWKWHSPSCFWLGEDRVTYSDARKMCSDYGSTLVTITNRFEQAYVSSLIYGWDGEYFWTALQDINETGAFRWLSGDEVMYTHWNRDQPGYNKGGCVALATGSSMGLWEVKNCSTFKAKYICRQNLGTPVNPELPSAYPTPSLTGTCPLGWSADPKLRHCYKVFNFDKLQEKKTWIAAQEFCRELGAQLLSLGSYEEEHFVANTLNKIFGESEPEIHEQHWFWIGLNRRDPSGDRSWRWSDGLGFFYHNFDRSNYDDDDIRNCAVLDLASLQWMPMQCEAQLDWICKLPKGTDVKEPEITTQGSKEWVKYQEAEYKFFEHHSTWMQAQRICSWFQAELVSVHSESELRFLGQNLKKFSRGQEQHWWIGLHTYENDGRFKWSDGSLLNFVSWAPGKPRPISKDKKCVYMTASREDWGDQKCPTALPYICKRSNATAVKPSIPPPPAPTSGGCPRGWVPFLSKCFSFNGHDKADIVKWPEAKQACESQGAVLATISSPLEQAFITSMLLNISFDLWIGLHDAKKEFQWVEDEPLRHVSWAPGEPSECSSSSPGDKPTNCVVVWHGSPPHFTGRWDDRSCVEEKHGYICQRSIDPSLSPARTPYPPSPTGTLFYHNSTYRILQKPLRWHEALLLCETLNATLVTIPDPYSQAFLTQAISSLRAPLWIGLANNEGGRSYSWLSEENLFYANWQDGEPQQAAGCAYMDVDGSWRTAGCDTKLQGGICQLQSGPPRTHKWSYSGSCPKSLEDSSWIPFRDHCYTFHMEITLGQKDAMRRCQKVGGSVLSIQDEMENVFVWEHLQAYEGSSKGAWLGMTFNPKGGTLVWHDNTAVNYSNWGQHDTGPSMLSQNSCYWIQSSNGVWRLGSCTNVTMGVICKIPRVEESSFSRAALPENTTAIAVVVLSALALSALLGIAIFLYKKRRSSERGAFESARYSRTTSNPSEAAEKNILVSDMEMNEQQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UE28</accession>
    <name>A0A8C2UE28_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">ARF like GTPase 8B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">ARL8B</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Early endosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Late endosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Lysosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015730827.1">
        <property type="nucleotide sequence ID" value="XM_015875341.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UE28"/>
    <dbReference type="Ensembl" id="ENSCJPT00005035758.1">
        <property type="protein sequence ID" value="ENSCJPP00005026415.1"/>
        <property type="gene ID" value="ENSCJPG00005020535.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107319947"/>
    <dbReference type="KEGG" id="cjo:107319947"/>
    <dbReference type="CTD" id="55207"/>
    <dbReference type="GeneTree" id="ENSGT00940000154861"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904115">
        <property type="term" value="C:axon cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101004">
        <property type="term" value="C:cytolytic granule membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051233">
        <property type="term" value="C:spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043014">
        <property type="term" value="F:alpha-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019003">
        <property type="term" value="F:GDP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008089">
        <property type="term" value="P:anterograde axonal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002747">
        <property type="term" value="P:antigen processing and presentation following phagocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002505">
        <property type="term" value="P:antigen processing and presentation of polysaccharide antigen via MHC class II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061909">
        <property type="term" value="P:autophagosome-lysosome fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990927">
        <property type="term" value="P:calcium ion regulated lysosome exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034498">
        <property type="term" value="P:early endosome to Golgi transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090117">
        <property type="term" value="P:endosome to lysosome transport of low-density lipoprotein particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902774">
        <property type="term" value="P:late endosome to lysosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032418">
        <property type="term" value="P:lysosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042267">
        <property type="term" value="P:natural killer cell mediated cytotoxicity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090385">
        <property type="term" value="P:phagosome-lysosome fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001778">
        <property type="term" value="P:plasma membrane repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902946">
        <property type="term" value="P:protein localization to early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046754">
        <property type="term" value="P:viral exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd04159">
        <property type="entry name" value="Arl10_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000247">
        <property type="entry name" value="ADP-ribosylation factor-like GTPase 8A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044154">
        <property type="entry name" value="Arl8a/8b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45732">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45732:SF13">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 8B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51422">
        <property type="entry name" value="SAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
    <keyword evidence="10 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="13" id="KW-0458">Lysosome</keyword>
    <keyword evidence="16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="16">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="130"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005026415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="186" mass="21495" checksum="F7F1AA42EEB93C9C" modified="2022-01-19" version="1">MLALLSRLLDSFQVLFWKEEMMLTLVRLQYSGKTTFVNVIASGQFSEDMIPTVGFNMRKVTKGNVTIKIWDIGGQPRFRSMWERYCRGVNAIVYMVDAADREKIEASRNELHNLLDKPQLQGIPVLVLGNKRDLPNALDEKQLIEKMNLAAIQDREICCYSISCKEKDNIDITLQWLIQHSKSRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UE65</accession>
    <name>A0A8C2UE65_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Retroelement silencing factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">RESF1</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015721695.2">
        <property type="nucleotide sequence ID" value="XM_015866209.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032301415.1">
        <property type="nucleotide sequence ID" value="XM_032445524.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005035146.1">
        <property type="protein sequence ID" value="ENSCJPP00005025891.1"/>
        <property type="gene ID" value="ENSCJPG00005020232.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107315636"/>
    <dbReference type="CTD" id="55196"/>
    <dbReference type="GeneTree" id="ENSGT00390000018491"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990226">
        <property type="term" value="F:histone methyltransferase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027866">
        <property type="entry name" value="RESF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21604">
        <property type="entry name" value="RETROELEMENT SILENCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21604:SF0">
        <property type="entry name" value="RETROELEMENT SILENCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15395">
        <property type="entry name" value="DUF4617"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="495"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="569"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="720"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1044"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1166"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1218"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1280"/>
            <end position="1336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1356"/>
            <end position="1444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1490"/>
            <end position="1523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1559"/>
            <end position="1608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="724"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1171"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1219"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1257"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1377"/>
            <end position="1392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1393"/>
            <end position="1403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1411"/>
            <end position="1420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1590"/>
            <end position="1602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005025891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1867" mass="206285" checksum="D251AF47E1AAF6F0" modified="2022-01-19" version="1">MDWNVRPLQNADAQNNLQSQESCYTQMLSNAQAFPQTNALSSVNACNYVGNNQVYLPTVNTASPGTSVAIKSFLTSEYSVNQPPPPYVPPAPTLPNQTSRAQGEMTQNSWQNPGRLISSHRKFPHLSSQMNGGSSVPNVLRGPHYATSNSYAVCSQTSQQRSLRTMLHQSNRECINSSKLGCIPQYNTNTSASSQSISVPISQSSSQYLHSQNNCLSFGMSGQHVQNQIHNSSTQIQFSQSLSQNTATNVHLPQYVPSQMGSGAPSGCSAPSLLPANYDSKTVAQPLLGAQQAVHNVFNKYPLQNCPSDKKNASGFNSVQQYSLKHQVGEVSQGVGNGYNSSGNVTVNHLFSEKSVPPTDISSELYDIVHGTVPFSSADASQPLCDPVSVQERQATSSVNVPANSQTSLAREDKRKMTGDTAAWETQRMQVIKRKCALLHRMHQYRRKLLTSKCDKSTSTLLSSFENALSNCLPQVPKQNVVPSLSQAVRIDSQQHSILGSSPEGRNDKNITGGDNRGLEVTQGNHQVEQGNLSSGPLPIPSHSELTALLNNTENSPVLEQKNALASSQKTLTPLNDASCYSQSNSSSRDASTSMESYPENSAFLQFVLSSTNMLKEKKAGTIADNILTNLLSNEKQQVDLTGLGGNLLKDTNEKVDLVPMVHTHTPVSEMMESNANKSHGDVGQKKMQFTENPCFKQNNGNYSLEELTACLGLWKKQGPEPVSVQNSQSNERTAANQISPLPHSQNTTNKREQGNLLVSTDVTVLPLTSTSVGQKHDTLSCNLIKGLELQIAVVSPLVLSNQKAQSEQVGKCPTAADKAYPVIEAGSICSMQEEGKNVSTVANTDKDMIESVSSSSDDCILIQTEDPCLQQTKSADGKSIVENSVNGNDSCGENERKLSQAMRDAEENLQNKVLPESGQEYIKDHDGKQAVLEIQNNTPSAVIEEQMFHIASVCSLVEGDKSYNPQIASIFSSVPQTHAFNSGTSSEENASDSRQKEQLMKLGKNDLRENTPQQETLLQKALRESSCCISEVDKTFCSTLTSHSKKESSGKLPRTVTTSEQKKPVNTPFKYPESDLGILASINQELARNSLDSLVSLTAETNAFTFTTCSSKENVTSTKKSIEEELHFFGAEPVMCLDNQLTELMKEFPFGIEGVDILTKEPARNSSMAEQRENQVQKETHVSAKKTDSKNPIDQLQIVQLNSGLVQESFPEKKLCSSAENSGALSQQPKKTSAQEDSLESSIQPSQSLCREKENPQSPSSSGNNEVCSLAGCLSASGEMSQSSCKRRTSVSDKNAEQPSEAENTYPAGRQDNNSKSDAVMKNDGVVENPPIRENVQNSIQKNIKDGCKDISVTSEKSQMNNEHKPLSPQPEKNGPLNSSEKQDVNSLKSSNWKEEMQESRRTLLLKKGFHSDKKDHQTVSEGELSEKAGCTDTDNVMKSSGKKEGILKVKSLSKDKTRTDLAMKSQRDLHKFTKSENVAIKHTEVYQEQKRKTCGKNPGKEQNCKKRNVGTNTEGKAKLSSEIKHEKLSSYRAEAMKFPNFGIRDLKSNNYTFSQHKAMKAHPPQEESYKRKRKDNMIGKTSSKKPKVKDERLKQSETKNSKRHSYDHKINTDKTKKLNGENVWKPKNSLADRSKLKLQRIRGLSTISKNHFSNKERHLDGQNKDKCSEKVFSDKNMLYLNRRTNRLKLHLQKEPKKHYLNRVAFKRTAQECIFLTKLETSPVRPVLHVKSQVSQHSLDSKRDASLSENEKPRKHQVLEFKLCPEILFRNSASDDESLAAKNSLEKEKSTVAGVKSKKEDWLKYDSVKQTKLKEIFTAEDCIPLDTAIQMLEGDDKALQIPIKDSKQMFQTYRKMYLEKKMDKPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UG04</accession>
    <name>A0A8C2UG04_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nuclear receptor subfamily 4 group A member 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">NR4A2</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_032301784.1">
        <property type="nucleotide sequence ID" value="XM_032445893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UG04"/>
    <dbReference type="SMR" id="A0A8C2UG04"/>
    <dbReference type="Ensembl" id="ENSCJPT00005035689.1">
        <property type="protein sequence ID" value="ENSCJPP00005026352.1"/>
        <property type="gene ID" value="ENSCJPG00005020500.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005035690.1">
        <property type="protein sequence ID" value="ENSCJPP00005026353.1"/>
        <property type="gene ID" value="ENSCJPG00005020500.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107317024"/>
    <dbReference type="KEGG" id="cjo:107317024"/>
    <dbReference type="CTD" id="4929"/>
    <dbReference type="GeneTree" id="ENSGT00950000183038"/>
    <dbReference type="OrthoDB" id="5952118at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035259">
        <property type="term" value="F:nuclear glucocorticoid receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004879">
        <property type="term" value="F:nuclear receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008344">
        <property type="term" value="P:adult locomotory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071376">
        <property type="term" value="P:cellular response to corticotropin-releasing hormone stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021952">
        <property type="term" value="P:central nervous system projection neuron axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042416">
        <property type="term" value="P:dopamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071542">
        <property type="term" value="P:dopaminergic neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045444">
        <property type="term" value="P:fat cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051866">
        <property type="term" value="P:general adaptation syndrome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021986">
        <property type="term" value="P:habenula development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001234">
        <property type="term" value="P:negative regulation of apoptotic signaling pathway"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043524">
        <property type="term" value="P:negative regulation of neuron apoptotic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051402">
        <property type="term" value="P:neuron apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042551">
        <property type="term" value="P:neuron maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001764">
        <property type="term" value="P:neuron migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042053">
        <property type="term" value="P:regulation of dopamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043576">
        <property type="term" value="P:regulation of respiratory gaseous exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001975">
        <property type="term" value="P:response to amphetamine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001666">
        <property type="term" value="P:response to hypoxia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd06969">
        <property type="entry name" value="NR_DBD_NGFI-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07071">
        <property type="entry name" value="NR_LBD_Nurr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.565.10:FF:000008">
        <property type="entry name" value="Nuclear receptor subfamily 4 group A member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000009">
        <property type="entry name" value="nuclear receptor subfamily 4 group A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003070">
        <property type="entry name" value="NR4A1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003073">
        <property type="entry name" value="NR4A2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24085">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24085:SF0">
        <property type="entry name" value="NUCLEAR RECEPTOR SUBFAMILY 4 GROUP A MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01284">
        <property type="entry name" value="NUCLEARECPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01287">
        <property type="entry name" value="NURRNUCRCPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="8 13" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="15">
        <location>
            <begin position="260"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="16">
        <location>
            <begin position="360"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="337"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="352"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
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            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005026352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="598" mass="66299" checksum="62D4A93104C2FE33" modified="2022-01-19" version="1">MPCVQAQYGSSPQGASPASQSYSYHSSGEYSSDFLTPEFVKFSMDLTNTEITATTSLPSFSTFMDNYNSSYDVKPPCLYQMPLSGQQSSIKVEDIQMHGYQQHGHLPPQPDDVMAHSGSVYYKPSSPPTPSTPGFQVQHGPVWDDAGSLHNFHPNYVATTHMIEQRKAPVSRLSLFSFKQSPPGTPVSSCQMRFDGPLHVPMNAEPAGPHHGVDGQPFAVPSPIRKQPAMAFPGLPLGHAPQLLDSQVPSPPSRGSPSNEGLCAVCGDNAACQHYGVRTCEGCKGFFKRTVQKNAKYVCLANKNCPVDKRRRNRCQYCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKSPQEPSPPSPPVSLISALVRAHVDSNPAMTSLDYSRFQANPDYQMSGDDTQHIQQFYDLLTGSMEIIRGWAEKIPGFTDLPKTDQDLLFESAFLELFVLRLAYRSNPVEGKLIFCNGVVLHRLQCVRGFGEWIDSIVEFSSNLQNMNIDISAFSCIAALAMVTERHGLKEPKRVEELQNKIVNCLKDHVTFNNGGLNRPNYLSKLLGKLPELRTLCTQGLQRIFYLKLEDLVPPPAIIDKLFLDTLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UG80</accession>
    <name>A0A8C2UG80_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="27">Volume-regulated anion channel subunit LRRC8A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="28">Leucine-rich repeat-containing protein 8A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="32" type="primary">LRRC8A</name>
    </gene>
    <organism evidence="32 33">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="32" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="32" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="32" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>2',3'-cGAMP(out) = 2',3'-cGAMP(in)</text>
            <dbReference type="Rhea" id="RHEA:66320"/>
            <dbReference type="ChEBI" id="CHEBI:143093"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:66321"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="25">
            <dbReference type="Rhea" id="RHEA:66322"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>L-aspartate(out) = L-aspartate(in)</text>
            <dbReference type="Rhea" id="RHEA:66332"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>L-glutamate(out) = L-glutamate(in)</text>
            <dbReference type="Rhea" id="RHEA:66336"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>chloride(in) = chloride(out)</text>
            <dbReference type="Rhea" id="RHEA:29823"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>iodide(out) = iodide(in)</text>
            <dbReference type="Rhea" id="RHEA:66324"/>
            <dbReference type="ChEBI" id="CHEBI:16382"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>myo-inositol(out) = myo-inositol(in)</text>
            <dbReference type="Rhea" id="RHEA:32867"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>taurine(out) = taurine(in)</text>
            <dbReference type="Rhea" id="RHEA:66328"/>
            <dbReference type="ChEBI" id="CHEBI:507393"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the LRRC8 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015734401.1">
        <property type="nucleotide sequence ID" value="XM_015878915.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015734402.1">
        <property type="nucleotide sequence ID" value="XM_015878916.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032303986.1">
        <property type="nucleotide sequence ID" value="XM_032448095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UG80"/>
    <dbReference type="Ensembl" id="ENSCJPT00005035279.1">
        <property type="protein sequence ID" value="ENSCJPP00005026002.1"/>
        <property type="gene ID" value="ENSCJPG00005020308.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107321726"/>
    <dbReference type="KEGG" id="cjo:107321726"/>
    <dbReference type="CTD" id="56262"/>
    <dbReference type="GeneTree" id="ENSGT00940000154043"/>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140360">
        <property type="term" value="F:cyclic-GMP-AMP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
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        <property type="term" value="P:cell volume homeostasis"/>
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        <property type="term" value="P:chloride transmembrane transport"/>
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        <property type="term" value="P:cyclic-GMP-AMP transmembrane import across plasma membrane"/>
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        <property type="term" value="P:intracellular glucose homeostasis"/>
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        <property type="term" value="P:positive regulation of insulin secretion"/>
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    <dbReference type="GO" id="GO:0045663">
        <property type="term" value="P:positive regulation of myoblast differentiation"/>
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        <property type="term" value="P:protein hexamerization"/>
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        <property type="term" value="P:response to osmotic stress"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Leucine-rich repeat-containing 8 VRAC subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="volume-regulated anion channel subunit LRRC8A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
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        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
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        <property type="entry name" value="LRR_domain-containing"/>
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        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
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        <property type="entry name" value="LRRC8_Pannexin-like"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF58">
        <property type="entry name" value="VOLUME-REGULATED ANION CHANNEL SUBUNIT LRRC8E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Pannexin_like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="5"/>
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    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0221">Differentiation</keyword>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="19" id="KW-0407">Ion channel</keyword>
    <keyword evidence="14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="18" id="KW-0458">Lysosome</keyword>
    <keyword evidence="15 29" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="33" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0744">Spermatogenesis</keyword>
    <keyword evidence="8 29" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 29" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="29">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="29">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="29">
        <location>
            <begin position="268"/>
            <end position="286"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="29">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="LRRC8 pannexin-like TM region" evidence="30">
        <location>
            <begin position="1"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="31">
        <location>
            <begin position="685"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00010471"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022475"/>
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            <dbReference type="ARBA" id="ARBA00022553"/>
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            <dbReference type="ARBA" id="ARBA00022614"/>
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            <dbReference type="ARBA" id="ARBA00022692"/>
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            <dbReference type="ARBA" id="ARBA00022737"/>
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            <dbReference type="ARBA" id="ARBA00022782"/>
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            <dbReference type="ARBA" id="ARBA00022989"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
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            <dbReference type="ARBA" id="ARBA00023065"/>
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            <dbReference type="ARBA" id="ARBA00023157"/>
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            <dbReference type="ARBA" id="ARBA00023180"/>
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            <dbReference type="ARBA" id="ARBA00023228"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00024145"/>
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            <dbReference type="ARBA" id="ARBA00024158"/>
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            <dbReference type="ARBA" id="ARBA00024167"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00035830"/>
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        <source>
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            <dbReference type="ARBA" id="ARBA00072524"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00075102"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF12534"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="810" mass="94339" checksum="91BFD6FEDA558326" modified="2022-01-19" version="1">MIPVTELRYFADTQPAYRILKPWWDVFTDYISIVMLMIAVFGGTLQVTQDKMICLPCKWITKDSCNDTVRGWTAVTPERIYYNSSLVPSADTGPTGIQYDLDRHQYNYVDAVCYENRLHWFAKYFPYLVLLHTLIFLACSNFWFKFPRTSSKLEHFVSILLKCFDSPWTTRALSETVVEESDTKPAFGKMNGSMDKKSSTVSEDVEATVPMLQRTKSRIEQGIVDRSETGVLDKKEGEQAKALFEKVKKFRTHVEEGDIVYRLYMRQTIIKVIKFILIICYTVYYVNNITFDVDCKVDIESLTGYRMYRCAHPLATLFKILASFYISLVVVYGLICMYTLWWMLRRSLKKYSFESIREESSYSDIPDVKNDFAFMLHLIDQYDPLYSKRFAVFLSEVSENKLRQLNLNNEWTLEKLRQRITKNSQDKLELHLFMLSGIPDTVFDLIELEVLKLELIPDVTIPPSIAQLTSLKELWLYHTAAKIEAPALAFLRENLKSLHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLTKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMVNLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPMQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTSIPPDIGLLQNLQNLAVTANRIENLPPELFQCRKLRTLNLGNNVLQSLPSRVGELTNLSQIELRGNRLECLPVELGECPLLKRSGLVVEEDLFNTLPLEVKERLWRADKEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UJX8</accession>
    <name>A0A8C2UJX8_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytoplasmic phosphatidylinositol transfer protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Retinal degeneration B homolog beta</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the transfer of phosphatidylinositol (PI) and phosphatidic acid (PA) between membranes. Binds PA derived from the phospholipase D signaling pathway and among the cellular PA species, preferably binds to the C16:0/16:1 and C16:1/18:1 PA species.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 1,2-diacyl-sn-glycero-3-phosphate(in) = a 1,2-diacyl-sn-glycero-3-phosphate(out)</text>
            <dbReference type="Rhea" id="RHEA:36435"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:36436"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(out)</text>
            <dbReference type="Rhea" id="RHEA:38691"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:38692"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PtdIns transfer protein family. PI transfer class IIB subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2UJX8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005037161.1">
        <property type="protein sequence ID" value="ENSCJPP00005027502.1"/>
        <property type="gene ID" value="ENSCJPG00005021315.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163128"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008526">
        <property type="term" value="F:phosphatidylinositol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08890">
        <property type="entry name" value="SRPBCC_PITPNC1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.530.20:FF:000011">
        <property type="entry name" value="cytoplasmic phosphatidylinositol transfer protein 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001666">
        <property type="entry name" value="PI_transfer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055261">
        <property type="entry name" value="PI_transfer_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10658:SF55">
        <property type="entry name" value="CYTOPLASMIC PHOSPHATIDYLINOSITOL TRANSFER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10658">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02121">
        <property type="entry name" value="IP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00391">
        <property type="entry name" value="PITRANSFER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="3" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034918006" description="Cytoplasmic phosphatidylinositol transfer protein 1" evidence="10">
        <location>
            <begin position="24"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidylinositol transfer protein N-terminal" evidence="11">
        <location>
            <begin position="17"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00051611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00055461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00061154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00068698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00082927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005027502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="287" mass="33787" checksum="0868B2D9CF32EDF1" modified="2022-01-19" version="1">MLILHKVNTLFLIFALQYRIGQLYMISKHSHEQSDRGEGVEVVQNEPYEDPNHGNGQLTEKRVYLNSKLPSWARAVVPKIFYVTEKAWNYYPYTITARFLYHVKHISLLLQCSFLPKFSIHIETKYEDNKGSNDSIFDNEAKDLEREVCFIDIASDEIPERYYKESEDPKYFKSQKTGRGQLKEGWRETHQPIMCSYKLVTVKFEVWGLQTRVEQFVHKVVRDILLIGHRQAFAWVDEWYDMTMDDVREYEKNMHEKTNIKVCNQHSSTVDEIESHGGFGLVSTSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UK63</accession>
    <name>A0A8C2UK63_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA polymerase subunit gamma-2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Mitochondrial DNA polymerase accessory subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">MtPolB</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">PolG-beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">POLG2</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Accessory subunit of DNA polymerase gamma solely responsible for replication of mitochondrial DNA (mtDNA). Acts as an allosteric regulator of the holoenzyme activities. Enhances the polymerase activity and the processivity of POLG by increasing its interactions with the DNA template. Suppresses POLG exonucleolytic proofreading especially toward homopolymeric templates bearing mismatched termini. Binds to single-stranded DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterotrimer composed of a catalytic subunit and a homodimer of accessory subunits (POLG:POLG2).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
            <location evidence="1">Mitochondrion nucleoid</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2UK63"/>
    <dbReference type="Ensembl" id="ENSCJPT00005037276.1">
        <property type="protein sequence ID" value="ENSCJPP00005027598.1"/>
        <property type="gene ID" value="ENSCJPG00005021381.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005760">
        <property type="term" value="C:gamma DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070182">
        <property type="term" value="F:DNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030337">
        <property type="term" value="F:DNA polymerase processivity factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006264">
        <property type="term" value="P:mitochondrial DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd02426">
        <property type="entry name" value="Pol_gamma_b_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000014">
        <property type="entry name" value="Putative dna polymerase subunit gamma-2 mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027031">
        <property type="entry name" value="Gly-tRNA_synthase/POLG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042064">
        <property type="entry name" value="POLG2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745:SF8">
        <property type="entry name" value="DNA POLYMERASE SUBUNIT GAMMA-2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745">
        <property type="entry name" value="GLYCYL-TRNA SYNTHETASE/DNA POLYMERASE SUBUNIT GAMMA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1135">Mitochondrion nucleoid</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Anticodon-binding" evidence="13">
        <location>
            <begin position="371"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00058907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00065608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00077312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00080083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00083605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005027598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="466" mass="52075" checksum="F864B6EF014A1F2A" modified="2022-01-19" version="1">CNVSAAVRPCELACRLTMRHRLCSPSLLRPLTAHGLDVVPPVRPYAESGGDAASGREEQLVALCRRRHFLRAEPFPWARDAPLRFGPLGVELRGNLCALWWDAVRGRREQVLPVDSPLHGHPADTSTAPRLLHSETLHQVLHSGGCSTERGGADLREALGSAGVLRDSLLHGALAQYVSCLELVNKRLPCGLAEVGVCFHSIPGGEQHNDKIGERTTSLLTWFSSPRTAGQWLDYWLRQRLQWWRKFAVGPSNFSSSDFQDEEGRRGFNLHYDFPWGTETIETLKNLGDTELLQMYPGDRSKLLGRDGRRSVLPHVLSVSGNLDLGALAYLFDSLQLAENSLTTKKSSQRKVLKLHPCLTPIKVALDVGKGPTTELRQVCQGLFNELSENRIAVWPGYLDTTQASLEQLYTKYDEMSVLFMVLISDSTLENGVVQLRSRDTTMKEMMHISRLKDFLIKYIESAKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y4X0</accession>
    <name>A0A8C2Y4X0_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Histone PARylation factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">HPF1</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HPF1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y4X0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005001217.1">
        <property type="protein sequence ID" value="ENSCJPP00005000696.1"/>
        <property type="gene ID" value="ENSCJPG00005000770.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000014876"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090734">
        <property type="term" value="C:site of DNA damage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072572">
        <property type="term" value="F:poly-ADP-D-ribose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140768">
        <property type="term" value="F:protein ADP-ribosyltransferase-substrate adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140861">
        <property type="term" value="P:DNA repair-dependent chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071168">
        <property type="term" value="P:protein localization to chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070212">
        <property type="term" value="P:protein poly-ADP-ribosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019361">
        <property type="entry name" value="HPF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13386">
        <property type="entry name" value="HISTONE PARYLATION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13386:SF1">
        <property type="entry name" value="HISTONE PARYLATION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10228">
        <property type="entry name" value="HPF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005000696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="326" mass="37163" checksum="9F51AF3680D27B77" modified="2022-01-19" version="1">MSAVRQKRSGQAEASNALQQEAETCYQLRLPEDFYQFWKFCEELDPEKPADALVSSVGLTLVGPYDILAGKHKKAKSTNVNFSLHWRFFYDPPEFQTILVGDSKTQYHMGYFRDVPDELPVWVGANEARKSCLISQVGDNVFAAVKLFLTKKLKEVTDKKKNAVLKDLDEKLTRRAKELGYSLEQKTTKMKQRDKKVVTKAFHGAGLVVPVDKNDVGYRELPETNTNLKKICKAIVDAPTDDERLKAFAPIQEMLTYVQFANDECDYGMGYELGMDLFCYGSHYFHKTVAQLLPLAYSLLRRNLFAEVIEAHLADRRQEGLDRLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y560</accession>
    <name>A0A8C2Y560_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">DEAD box protein 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">DDX4</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DDX4/VASA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y560"/>
    <dbReference type="Ensembl" id="ENSCJPT00005002180.1">
        <property type="protein sequence ID" value="ENSCJPP00005001284.1"/>
        <property type="gene ID" value="ENSCJPG00005001336.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157507"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome Z"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030317">
        <property type="term" value="P:flagellated sperm motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18052">
        <property type="entry name" value="DEADc_DDX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000397">
        <property type="entry name" value="Probable ATP-dependent RNA helicase DDX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0469">Meiosis</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="15">
        <location>
            <begin position="261"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="292"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="500"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="36"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="663"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="10">
        <location>
            <begin position="261"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="51"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="677"/>
            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00081176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005001284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="688" mass="75700" checksum="FD2DA839D87D9612" modified="2022-01-19" version="1">MAVSGRGVLLSPAPGFAGELLSFAMEEDWDTELLEQEAAAAPLRRNEEQVWATNSGRPNSPSHRFSNRPTSPLSGFPGTPNSPFFGLSQNKGSLGANEGFNRSLHAQRDTGGSFGSRDSAVHQNREDRPVTRLGRGRSFGSRDSQERNSTNEPGMREQGFRGVSGIFGQNKCFNSEEKNSPLRGSPFASGGRGAVGGLAGAHKGRSEEIDAGRGPKVTYVPPPPPDDEQSIFASYQTGINFDKYDECTADMTGIDPPAPLLTFEEANFSQTLRKNISKTGYSKLTPVQKYSIPVIQAGRDLMACAQTGSGKTAAFLLPIVDRMMKDGVTASVFKKQQEPQCIIVAPTRELINQIFLEARKFVYGTCIRPVVIYGGTQTGHSIRQIMQGCNILCATPGRLLDIIEKEKISLVEVKYLVLDEADRMLDMGFGLDMKKLISYPDMPSKDRRQTLMFSATFPQEVQRLAGEFLKTDYIFLVIGNTCGACSDVQQNILQVPRLSKRDKLIEVLQSTGGERTMVFVETKKKADYIAAFLCQENLPSTSIHGDREQREREIALHDFRSGKCQILVATSVAARGLDIENVQHVINFDLPNTIEDYVHRIGRTGRCGNPGKAVSFFDDQSDSHLVQSLLKVLSEAQQEVPAWLEEMALERPNTVSSLGAQRINTGSSRVNPGGKTMSYTERTFQSWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y683</accession>
    <name>A0A8C2Y683_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Tyrosine-protein kinase</fullName>
            <ecNumber evidence="13">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">SRMS</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 13">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the protein kinase superfamily. Tyr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="13"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y683"/>
    <dbReference type="Ensembl" id="ENSCJPT00005005381.1">
        <property type="protein sequence ID" value="ENSCJPP00005002954.1"/>
        <property type="gene ID" value="ENSCJPG00005003222.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161518"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031669">
        <property type="term" value="P:cellular response to nutrient levels"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd05148">
        <property type="entry name" value="PTKc_Srm_Brk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11846">
        <property type="entry name" value="SH3_Srms"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000399">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000234">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000053">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000078">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="1 11" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="3 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 13" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="SH3" evidence="15">
        <location>
            <begin position="51"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="14">
        <location>
            <begin position="120"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="230"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005002954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="516" mass="58927" checksum="877B638D2BBD4538" modified="2022-01-19" version="1">MEQFVRKRLTFLTSFWNKLWPRSSPDSCSLGYFGSDSVSLHSEPSCVSFIPKSSLFIALYAFTARSADELSVNAGDKLRVLREEGDYVLARRLLGEPATGYVPAAYVANLSQGTSAHRPWYFSKISRNEAEQLLLSPPNQHGSFLVRDSESSRGEYSLSVRNHTKVSHFRICKSPAGSLYIQRGHPFPNMEELLAFYTENWKVIQSPLLQPCSPTTPPERDGWERPRWEFTLRRKLGEGYFGEVWEGLWRNTVPVAIKIIKADMKAEDFTKEIQNLKRLRHEKLIQLHAVCSLDEPVYIITELMRKGNLHSYLNSASLLLQTSGLGLWQQLVPEEKELAGPEGKSLGTSHLLNIACQVADGMRYLEEKHIVHRDLAARNILVGEELTCKIADFGLARLLKDDIYSTSSSTKIPVKWTAPEAANYRTYSLKSDVWSYGILLYEVFTYGQIPYEGMTNQETIRQITRGYRLPRPSPCPPEIYSIMLECWSGNTEERPTFMALREKLGFIYRRLFNTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y6E4</accession>
    <name>A0A8C2Y6E4_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PDZ domain-containing protein 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">PDZD11</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015715560.1">
        <property type="nucleotide sequence ID" value="XM_015860074.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y6E4"/>
    <dbReference type="SMR" id="A0A8C2Y6E4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005005959.1">
        <property type="protein sequence ID" value="ENSCJPP00005003338.1"/>
        <property type="gene ID" value="ENSCJPG00005003542.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107312549"/>
    <dbReference type="KEGG" id="cjo:107312549"/>
    <dbReference type="CTD" id="51248"/>
    <dbReference type="GeneTree" id="ENSGT00940000153222"/>
    <dbReference type="OrthoDB" id="6021951at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046931">
        <property type="term" value="P:pore complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd06752">
        <property type="entry name" value="PDZ_PDZD11-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000096">
        <property type="entry name" value="PDZ domain-containing protein 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051109">
        <property type="entry name" value="MAM_complex_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14063">
        <property type="entry name" value="PROTEIN LIN-7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="47"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00039345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005003338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="140" mass="16131" checksum="52BD038BE55F56FE" modified="2022-01-19" version="1">MEGRLPYDDFPVVFLPPYESPPAWVPPHERVYHPDYNNELTQFLPRTVVLKKPPGAQLGFNIRGGKASQLGIFISKVIPDSDAHRAGLQEGDQVLSVNDVDFQDIEHSKAVEILKTAREITMRVRYFPYNYQRQKERTVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y6W4</accession>
    <name>A0A8C2Y6W4_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Heat shock factor protein 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Heat shock transcription factor 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">HSF5</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">DNA-binding transcription factor that is essential for male fertility, spermatogenesis and meiotic prophase progression in spermatocytes under non-stress conditions. Positvely and negatively regulates gene expression to ensure progression of meiotic prophase beyond pachytene stage in spermatocytes. Plays a role in male germline meiotic sex chromosome remodeling and silencing through regulation of SMARCA4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the HSF family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y6W4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005007300.1">
        <property type="protein sequence ID" value="ENSCJPP00005004361.1"/>
        <property type="gene ID" value="ENSCJPG00005004318.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00510000048674"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001216">
        <property type="term" value="F:DNA-binding transcription activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001217">
        <property type="term" value="F:DNA-binding transcription repressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007140">
        <property type="term" value="P:male meiotic nuclear division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000531">
        <property type="entry name" value="Heat shock transcription factor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF278">
        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0221">Differentiation</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="15" id="KW-0469">Meiosis</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0678">Repressor</keyword>
    <keyword evidence="9" id="KW-0744">Spermatogenesis</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="21">
        <location>
            <begin position="11"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="93"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="143"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="389"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="535"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="20">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="400"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="562"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00054015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00070265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00079386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005004361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="598" mass="65181" checksum="4753A750E8A88B24" modified="2022-01-19" version="1">MEEPLLPAAINPNNFPAKLWRLVNSPRFRSIRWDARGEGLLIDQPLFEAELLGRAGPRSAGDGAAGELFKTTNFTSFIRQLNLYGFRKVVAGPPGPRAGSGPDNDGGSGGHLHHFHSPHFRRDRPDLLVHLKRMTSANKAKLAAGLEVSSRPPNRFQRPPGDTPPSPPTPAALTRPLGLPRAEAHGLLAVGQFHRPYQRDSLFPYSYMSASPQNHGSLPSKSLDRTPIPPRTWQSSLGLIAGHKASAAFPDKGIAFPIFQRFPTEVTYTLQSSASPVPLQQVSQAIATSPAKYSSYTSPLHYSQAYYPTAALPCCSPATHISPLTCCASPTALTYTHCSLFQSPPMQSPYAVEFLPSNWPYHTSDESKKTEVNLEAVFQIVDEMRSSPKVGTVKVEPVENQWSSPQTSRGQPQLAGTENDDPPSDEEGRLEPLTPVVSDVTPFVVGDQEAPCSLPQPLDYFYALHTTASVECAAAQMVREPAATQEARGKLREEPDHLPAQFSAMIVREVQSFSPQKVDTGVKCPFLRSETEEVGCPTSGAGPVKKTVENTVSSAKTRNRERRSNSKECKSPGKKGFYFVFGGQQGSCSETSHYRQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y7I9</accession>
    <name>A0A8C2Y7I9_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Uridine-cytidine kinase</fullName>
            <ecNumber evidence="10">2.7.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">UCK1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>cytidine + ATP = CMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>uridine + ATP = UMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16825"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.48"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the uridine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.48" evidence="10"/>
    <dbReference type="RefSeq" id="XP_015734500.1">
        <property type="nucleotide sequence ID" value="XM_015879014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y7I9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005009268.1">
        <property type="protein sequence ID" value="ENSCJPP00005005771.1"/>
        <property type="gene ID" value="ENSCJPG00005005442.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107321762"/>
    <dbReference type="KEGG" id="cjo:107321762"/>
    <dbReference type="CTD" id="83549"/>
    <dbReference type="GeneTree" id="ENSGT01020000230412"/>
    <dbReference type="OrthoDB" id="10257085at2759"/>
    <dbReference type="UniPathway" id="UPA00574">
        <property type="reaction ID" value="UER00637"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00579">
        <property type="reaction ID" value="UER00640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043771">
        <property type="term" value="F:cytidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004849">
        <property type="term" value="F:uridine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044211">
        <property type="term" value="P:CTP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044206">
        <property type="term" value="P:UMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02023">
        <property type="entry name" value="UMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000297">
        <property type="entry name" value="Uridine-cytidine kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000764">
        <property type="entry name" value="Uridine_kinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004018">
        <property type="entry name" value="PRK05480.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00235">
        <property type="entry name" value="udk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00988">
        <property type="entry name" value="URIDINKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribulokinase/uridine kinase" evidence="12">
        <location>
            <begin position="18"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="263"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005005771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="272" mass="30790" checksum="25B8354F38677BB4" modified="2022-01-19" version="1">MASAGGTEPDRPHPKPFLIGVSGGTASGKSTVCEKIMELLGQNEVERRQRKVLILSQDSFYKVLTAEQQGKALKGQYNFDHPDAFDNDLMRTTLKNIVEGKTVEVPTYDFVTHSRMPDTTVVYPADVVLFEGILVFYNQDIRDMFHLRLFVDTDSDVRLSRRVLRDMKRGRDLEQILTQYTTFVKPAFEEFCLPTKKYADVIIPRGVDNMVAINLIVQHIQDILNGDICKWQRGAVNGHGRTYKRPFSEQAESSSVLAAGKRSHLESSSRPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y805</accession>
    <name>A0A8C2Y805_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Golgi resident protein GCP60</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Acyl-CoA-binding domain-containing protein 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Golgi complex-associated protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Golgi phosphoprotein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">ACBD3</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Involved in the maintenance of Golgi structure by interacting with giantin, affecting protein transport between the endoplasmic reticulum and Golgi. Involved in hormone-induced steroid biosynthesis in testicular Leydig cells. Recruits PI4KB to the Golgi apparatus membrane; enhances the enzyme activity of PI4KB activity via its membrane recruitment thereby increasing the local concentration of the substrate in the vicinity of the kinase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015712589.1">
        <property type="nucleotide sequence ID" value="XM_015857103.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y805"/>
    <dbReference type="Ensembl" id="ENSCJPT00005010599.1">
        <property type="protein sequence ID" value="ENSCJPP00005006791.1"/>
        <property type="gene ID" value="ENSCJPG00005006282.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107310962"/>
    <dbReference type="KEGG" id="cjo:107310962"/>
    <dbReference type="CTD" id="64746"/>
    <dbReference type="GeneTree" id="ENSGT00530000063651"/>
    <dbReference type="OrthoDB" id="5839451at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034237">
        <property type="term" value="F:protein kinase A regulatory subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000017">
        <property type="entry name" value="Golgi resident protein GCP60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.680:FF:000002">
        <property type="entry name" value="Putative Golgi resident protein GCP60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.680">
        <property type="entry name" value="GOLD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022408">
        <property type="entry name" value="Acyl-CoA-binding_prot_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052269">
        <property type="entry name" value="Golgi-PI4KB_interaction"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22973:SF11">
        <property type="entry name" value="GOLGI RESIDENT PROTEIN GCP60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22973">
        <property type="entry name" value="LD35087P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13897">
        <property type="entry name" value="GOLD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00880">
        <property type="entry name" value="ACB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0752">Steroid biosynthesis</keyword>
    <feature type="domain" description="ACB" evidence="19">
        <location>
            <begin position="71"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="18">
        <location>
            <begin position="374"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="21"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="170"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="434"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="440"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00057952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00067322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00076235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00078007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00080905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="518" mass="59615" checksum="327D9C2C8C284444" modified="2022-01-19" version="1">MAVALSAERLEVSVDGLTLSPNAEAPPCEARPGHGDSAAGRNRAGPGCQSQVEAGGEEAALSPERSWGFALEELYGLALRFFKEKDGKAFHPTYEEKLRLVALHKQVLLGPYNPDTCPEVGFFDVLGNDRRKEWAALGNMSKQEAMTEFVKLLNRCCHLFSTYVTSHKIEKEEQEKKRREEEERRRREEEELERLQREEEKRRQEEEERLRREEEERRRIEEERLRMEQQKQQIMAALNSQTAMQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQVQLAQQQAALQKQQEAVVAAAGTPLTTASKVNVPAQGEMPSINGQTSAHTDNPEKELDPEALEEALENGPKDSVPVIAAPSMWTRPQIKDFKEKIRQDADSVITVGRGEVVTVRVPTHEEGSYLFWEFATDNYDIGFGVYFEWTDSPNTAVSVHVSESSDDEDEEEENASSEEKAKKNANKPQLDEIVPVYRRDCHEEVYAGSHQYPGRGVYLLKFDNSYSLWRSKTVYYRVYYTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y845</accession>
    <name>A0A8C2Y845_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lactamase beta like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LACTBL1</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta-lactamase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015738321.1">
        <property type="nucleotide sequence ID" value="XM_015882835.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y845"/>
    <dbReference type="Ensembl" id="ENSCJPT00005011473.1">
        <property type="protein sequence ID" value="ENSCJPP00005007390.1"/>
        <property type="gene ID" value="ENSCJPG00005006822.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107323575"/>
    <dbReference type="KEGG" id="cjo:107323575"/>
    <dbReference type="CTD" id="646262"/>
    <dbReference type="GeneTree" id="ENSGT00450000040404"/>
    <dbReference type="OrthoDB" id="5946976at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051478">
        <property type="entry name" value="Beta-lactamase-like_AB/R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22935:SF95">
        <property type="entry name" value="BETA-LACTAMASE-LIKE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22935">
        <property type="entry name" value="PENICILLIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase-related" evidence="3">
        <location>
            <begin position="90"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005007390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="582" mass="65768" checksum="378D02A9AA7D2A6C" modified="2022-01-19" version="1">MQASSSRGLLKLSVMEVKWIHVLVIFFFLLSVAMTGCFLWQYSLPRVEPNPSVMEVRSESVQMCPRYPEPVPLDHPIPILKDALEKVDLMLRQKIHSSGLPAMSAIVIYNDTVLWTGNFGKKNASDPFSVVPNEYTIYRIASVSKIFPTLMLYKMWEEGKVTSLDDPLERYAQNFAIKNPLGRFKESEQRYTADGLIFVEKGSIPLKPSPVTLRRMASQLSGLPRRLRSTSLLWKGSTQEALALLKDDVLVADPGTRCHYSNLAFSLMAHVLADHAADGQYQRWISENILDRLGMEDTGFDITPPIRSQMAVGFYSSQQPAPLYDLGWYRPSGQMYSTAADLAKLAMVFLGTYHRRLLEPDTVKTMLTPLFKCSTEYFANKTGTPWEINEQLGYDVIRKDGDLDGYSATFSLIPKLRLSFIVLMAGPRPQGGDLVTQTYGYLITAMETAFREAEKTLTPPPSPVPFVGYYTYSNLTFYEIKVGRGGVLVMQQFGPHAEELIPEKYRTIKLHHLEDRVFQVVFDKEFPCVLHLGSASISLETQNGQLFNFYPFDRKGLSPGFDAPGLNTYNVVRVLRKPVFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y8T7</accession>
    <name>A0A8C2Y8T7_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Holocarboxylase synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">HLCS</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the biotin--protein ligase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015737782.1">
        <property type="nucleotide sequence ID" value="XM_015882296.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y8T7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005013307.1">
        <property type="protein sequence ID" value="ENSCJPP00005008831.1"/>
        <property type="gene ID" value="ENSCJPG00005007836.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107323321"/>
    <dbReference type="CTD" id="3141"/>
    <dbReference type="GeneTree" id="ENSGT00390000002960"/>
    <dbReference type="OrthoDB" id="10250105at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005652">
        <property type="term" value="C:nuclear lamina"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009374">
        <property type="term" value="F:biotin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004077">
        <property type="term" value="F:biotin--[biotin carboxyl-carrier protein] ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043687">
        <property type="term" value="P:post-translational protein modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070781">
        <property type="term" value="P:response to biotin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd16442">
        <property type="entry name" value="BPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
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        <property type="entry name" value="Biotin-prot_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004408">
        <property type="entry name" value="Biotin_CoA_COase_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003142">
        <property type="entry name" value="BPL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00121">
        <property type="entry name" value="birA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12835">
        <property type="entry name" value="BIOTIN PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12835:SF5">
        <property type="entry name" value="BIOTIN--PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02237">
        <property type="entry name" value="BPL_C"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09825">
        <property type="entry name" value="BPL_N"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034474811" evidence="4">
        <location>
            <begin position="20"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="domain" description="BPL/LPL catalytic" evidence="5">
        <location>
            <begin position="618"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="194"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="194"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005008831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="889" mass="99388" checksum="19CC1FD8262CDE7D" modified="2022-01-19" version="1">MLITLCYLYLWARWGPCSAALIRRTVRRLHRSRCSFTFCCSAGPAAPPAHPPPPEERVCLRIGNKVFFTGETQLLDDLNRWSLLLISPFIYPDKLLAAEHIAFVTESVSAQTDNLPKLPVSSKEIVKWSDYCSPLAYKPGEPYKLIAEASVDNFSNLGIAFMEDRLQMDNGMVPCKIVSVHLQETTLEELKQVTPSMKQKSVSITQMDETTPDTFGTTVKTQLRGVAESAGQDDSDTKEEQPKLGKKNEDESSSLSDKETGFGEHHHLHLSSCHECLQLENSTIESVRFASVEDIPELPDDCSSKLEENGDCLTAGIKRVNLAGKPPNILIYVGSGSAKVDFEQVKSIIQECVDTDSYTIYQLHEEQVLKAPWIDNSLLLIIATGRPISEKNQKQFMKFLSKGGKILGLSSSFTFGGVQIKTKDKLKRTVHELVVSKMDRTEMKLNLLISGCMFEVAMEEGSSKAKPLSYLNNADKDIVIVHLPYGDNGGEAILSQVHLELDTNSMDIQTEEDFNLLKMSNPKRYEVLKEILISLGLSCELNEIPMLTPIYLLSSDEEIHLTFLKWLEENVNVEGLIESSKVSLKFVSSCESKMEITPSLMSVVTKMGNFSSEHFSLETYQRNLQTKKLGKILFFTEVTTSTMNLLDGLMFKLPEEMGLIAIAVRQTQGKGRGRNAWLSPIGCALSTVHITIPLHSNLGQRIPFIQHLVSLAVVESVRSIPGYEDIDLRVKWPNDIYYSDLMKLGGVLVTSTLIETTFHILIGFGFNVNNSNPTICINDLITKFNKEEGTNLKALTADCLIARTVTVLERLIDIFQEKGPNGVLPRYYKYWVHSGKQVRLHNEEGPLAWIVGIDDYGFLQVHEEGKGVESVHPDGNSFDMLKNLIIPKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y9I2</accession>
    <name>A0A8C2Y9I2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Alpha-tectorin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">TECTA</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">One of the major non-collagenous components of the tectorial membrane. The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
            <orientation evidence="1">Extracellular side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Extracellular space</location>
            <location evidence="2">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <dbReference type="Ensembl" id="ENSCJPT00005014791.1">
        <property type="protein sequence ID" value="ENSCJPP00005009937.1"/>
        <property type="gene ID" value="ENSCJPG00005008677.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183155"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005201">
        <property type="term" value="F:extracellular matrix structural constituent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060088">
        <property type="term" value="P:auditory receptor cell stereocilium organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007605">
        <property type="term" value="P:sensory perception of sound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="3"/>
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        <property type="entry name" value="alpha-tectorin isoform X1"/>
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        <property type="entry name" value="alpha-tectorin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tectorin alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4100">
        <property type="entry name" value="Zona pellucida, ZP-C domain"/>
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    </dbReference>
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        <property type="entry name" value="Zona pellucida, ZP-N domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052749">
        <property type="entry name" value="Alpha-tectorin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003886">
        <property type="entry name" value="NIDO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002919">
        <property type="entry name" value="TIL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025615">
        <property type="entry name" value="TILa_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014853">
        <property type="entry name" value="VWF/SSPO/ZAN-like_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001007">
        <property type="entry name" value="VWF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055355">
        <property type="entry name" value="ZP-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042235">
        <property type="entry name" value="ZP-C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017977">
        <property type="entry name" value="ZP_dom_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46160:SF3">
        <property type="entry name" value="ALPHA-TECTORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46160">
        <property type="entry name" value="ALPHA-TECTORIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08742">
        <property type="entry name" value="C8"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06119">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01826">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12714">
        <property type="entry name" value="TILa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00100">
        <property type="entry name" value="Zona_pellucida"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00832">
        <property type="entry name" value="C8"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00539">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00215">
        <property type="entry name" value="VWC_out"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00216">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51220">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00682">
        <property type="entry name" value="ZP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="9" id="KW-1009">Hearing</keyword>
    <keyword evidence="13" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034121207" description="Alpha-tectorin" evidence="16">
        <location>
            <begin position="25"/>
            <end position="2213"/>
        </location>
    </feature>
    <feature type="domain" description="NIDO" evidence="18">
        <location>
            <begin position="98"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="19">
        <location>
            <begin position="320"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="19">
        <location>
            <begin position="709"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="19">
        <location>
            <begin position="1096"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="19">
        <location>
            <begin position="1486"/>
            <end position="1662"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="17">
        <location>
            <begin position="1801"/>
            <end position="2055"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022740"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00058814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00070182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005009937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="2213" mass="244349" checksum="A362D8E9E71E153E" modified="2022-01-19" version="1">MNTRSLLSTWAALLVVTVRHQAQAMASLYPFWPNDTKTPKVDDGSSPEIKLSIPFIFFGAPYRTVYVNNNGVISFNSLVSQFTPEAFPLADGRAFVAPFWADVHNGIRGEIYYRESTDPELLGRASKDIRKYFKDMASFSARWVFVVTWEEVTFYGGSSTTPVNTFQAVLITDGVSSFAIFNYQEISWTTGTASGGDPLTGLGGVMAQAGFNGGNISNFFSIPGSRTPDIVNIEQTTNVNIPGRWAFKIDGREIDPANGCSLRGQFLHQGEIFWENSNCSTKCRCLDFNNEIFCQEMACGPFEACEPKIKFFQCVPVESSTCVVFGDPHYHTFDGFLFHFQGSCSYLLARQCWPGSQLPYFNVEAKNENRGGSSVSWLRDIFVEVYSHKIVLPKGSFGKAKVDDLVVSLPISLELGAIKVYQSGLSTALETDFGLMVTYDGQHYASVSVPGTYINGTCGLCGNYNKDPEDDALRSDGRLASSVPELGESWRVPHPERKCSPGCVENCSICDASTESLYFSPEYCGFLNKTGGPLWECGSVVDPTAFVHSCVYDLCSGRENSTGLCQAIQAYAAVCQGLGIPVGEWRAQTGCVVQCPDHSHYSVCASGCPATCSDLTAPLRCAAPCAEGCECDDGHVLSADLCIPVQKCGCDVDGRYYAVGEVFWATADCTSECQCEDGGEAKCFNTSCPEGEVCAIEDGYRGCYPKREGLCSVGQNQVLRTFDGVTFPYPLEHSYTLIKTCMEKPDFIEVDISQKKPGYAPNGLRVVRIQVVGQEVKVGGASLSEVKVNGYDVDLPYFHPSGHLEIYRTDNGTVMESEGLLNIGYYDSGLLEIRLSTTFFNCTGGLCGFFNGNASDEFCTPKGKCTDNLELFLESWTTFDEICNGECGDLLKACNNDSELLKTYRSRSNCGIINDPTNSSFLECHSVVNVSAYYRTCLFRLCQSGGNQSELCDAVARYASACKNAEVDVGQWRSHSFCPLACPENSHFEECMSCVETCETLATGPVCTDTCTEGCQCDEGFALRGSRCVPRGECGCNFEGRQLATNQTFWMDISCHFLCYCNGSDNSVYCENVSCKDDEYCLEENGLYYCHVRTDASCIVSGYGHYLTFDGFSFDFQSSCALVLCTTISRPRAERSDTFPTFTVTAKNEDRDTSLALWVKQVEVEVFNYNIVIHRAYKYTVMINNERLYLPLKLGQGKVNIFAFGFHIVVETDFGLKVVYDWKTFLSVTIPRSFQNLTYGLCGRYNGNPDDDLVAAGGMPAFSVTDFVQSWAKRDTFCRVGCGDRCPACGKVEGFWKPQQLCSLIPSQSGVFAKCHSKINPSYFYKNCLFDTCVDGGAMQTACGWLQNYASTCQTQGIAIIGWRNFTSCSVSCPPNSHYESCVSLCQPRCAAIRLKSDCGHYCVEGCQCDPGYVLNGKSCILPQNCGCYSDGKYYEPKQLFWNGDCTRRCRCFRRNLIQCDPRHCKSDEECASRNGVRGCFSTRSSFCLAAGGGVFRTFDGAFLRFPANCAFVLSTICQKLPDFSFQLIINFDKWSSPNLTVISPVYFYINEEQILISDRNTVKVNGSLVSIPFVTGLSTKIYSHEGFLVIDSGPDIQIRYNGFNVIKITIGDRLQNKVCGLCGNFNGDPADDYATLRGKPVVSSVVLAQSWKTNGMQKSCNELQYSQYAASCDNVQIQKLQSDSYCLKLTDMKGFFQPCYGLLDPLPFYESCFLDGCYNRKQVQLCGSLAAYGEACRTFGILGTEWIEKENCSGVVEDPCAGADCPNRTCELDDGGELCGCIEPPPYGNTTHDIIDAEVTCKAAQMEVSISKCKLFQLGFEREGVRVNDRHCPGIEGEDFISFQINNTKGNCGNLVQSNSTHIVYKNTVWIESANNTGNIITRDRTINVEFSCAYELDIKISLDSVVRPMLSVINLTVPTQEGSFTTKMALYKNSSYKHPYRQGEVVLTTRDVLYVGVFVVGADSNHLILMLNKCYATPSRDSNDKLRYFIIEGGCQNLKDNTIGIEENGVSLTCRFHVTVFKFIGDYDEVHLHCAVSLCDSEKYSCKINCPQHRRSASAFGHEAHEQILSVGPIRRKRSDWCEDNGGCEQICTSQADGPLCSCVTGTLQGDGKSCRGKHWGLAQSSYRVGRGFSYAKKLGKEWTSKHPLHPYTESFFISQPPAHQQTAEPKRAFWCWHSCGCGQLCRTRPHRGGSAARPCTVLVSARVSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YA02</accession>
    <name>A0A8C2YA02_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sphingomyelin phosphodiesterase 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">SMPD4</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015733555.1">
        <property type="nucleotide sequence ID" value="XM_015878069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YA02"/>
    <dbReference type="Ensembl" id="ENSCJPT00005016157.1">
        <property type="protein sequence ID" value="ENSCJPP00005011005.1"/>
        <property type="gene ID" value="ENSCJPG00005008967.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107321304"/>
    <dbReference type="KEGG" id="cjo:107321304"/>
    <dbReference type="CTD" id="55627"/>
    <dbReference type="GeneTree" id="ENSGT00390000006044"/>
    <dbReference type="OrthoDB" id="10251508at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004767">
        <property type="term" value="F:sphingomyelin phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050290">
        <property type="term" value="F:sphingomyelin phosphodiesterase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071356">
        <property type="term" value="P:cellular response to tumor necrosis factor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006685">
        <property type="term" value="P:sphingomyelin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024129">
        <property type="entry name" value="Sphingomy_SMPD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12988">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12988:SF6">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14724">
        <property type="entry name" value="mit_SMPDase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="785"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="809"/>
            <end position="830"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005011005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="835" mass="95957" checksum="83D3DD4AAE2960E0" modified="2022-01-19" version="1">MAEMRREDMAGVYLQQPSYLLATLKADCINKPFAQRCHDLETVIEEFPAKELHGIFPWLVESIFGSLDGTIVGWNLRCLQGRTNPTEYSVALDFLDPSGPMMKLVYKLQAEEYRYDFPVSYLPGPVKASIQEQVLPECSLYHNKVQFPSSGGLGLNLALNPFEYYMFYFAISLITQKNSPITQHISPSNSAYFILVDTYLKCFLPTEGSVLPPPSSNPGGAIPSPTPRTPAVPFTSYGMHHTSLLKRHIAHQPSVNADPASQEIWRSETLLQIFVEMWLHHYSLEMYQKMQSPHVKLEVLHYRLSISSKHHGSPAQSSYQALHAYQESFKPTEEHVLVVRLLVKHLHAFSNSLKPEPLSPSAHSHTASPLEEFKRVVIPRFVQQKLYIFLQHCFGHWPLDASFRAVLEMWLSYLQPWRYAPEKPPQTAEVLPRSVPEKWAAFIQENLLMYTKLFVGFLNRTLRTDLVSPKNALMVFRVAKVFAQPNLAEMILKGEQLFLEPELVIPHRQHRLFMSPTLGGSFLSSWPPTITDASFKVKSHVYSLEGQDFQYKQMFGTEVRNLVLKLAQLICQAQQTAKSISDHSAETASSYSFFSWFKFTPSEMNGSYTGNDLDEIGQDSIKKTDEYLEKALEYLCQIFKLSEAQLNQMMMKCGTAQDENGKKQLPDCIESENGLILTPLGRYQMINGLRRFDVRYQGDTELQPIRSYENATLVRLLYRLSSALNERFAERMDMLCSREDFVGRFCRYHLTNPHLAHRIRYSPAVKDGTNQNWGPRISLRFLASYRTLVSLLMLYFIASWFYIGPVGCTFIILFSYFLYAVIMTFFFEAWKPHEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YAL1</accession>
    <name>A0A8C2YAL1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Prolyl 4-hydroxylase subunit alpha-1</fullName>
            <ecNumber evidence="5">1.14.11.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">P4HA1</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the P4HA family.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.2" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2YAL1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005018168.1">
        <property type="protein sequence ID" value="ENSCJPP00005012553.1"/>
        <property type="gene ID" value="ENSCJPG00005009698.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156635"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016222">
        <property type="term" value="C:procollagen-proline 4-dioxygenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030199">
        <property type="term" value="P:collagen fibril organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000006">
        <property type="entry name" value="Prolyl 4-hydroxylase subunit alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.620:FF:000001">
        <property type="entry name" value="Prolyl 4-hydroxylase subunit alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013547">
        <property type="entry name" value="P4H_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059068">
        <property type="entry name" value="TPR_P4H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF101">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08336">
        <property type="entry name" value="P4Ha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23558">
        <property type="entry name" value="TPR_P4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0732">Signal</keyword>
    <keyword evidence="7 16" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="9" id="KW-0847">Vitamin C</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034028331" description="Prolyl 4-hydroxylase subunit alpha-1" evidence="17">
        <location>
            <begin position="22"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="16">
        <location>
            <begin position="209"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="18">
        <location>
            <begin position="413"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005012553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="565" mass="64904" checksum="74A82BD74E236EEF" modified="2022-01-19" version="1">MASNKMWYTLALGFLLPFSYAHTDFFTSIGHMTDLINTEKDLVISLKDYIKAEESKLEQIKKWAEKLDKLTDTATKDPEGFLGHPVNAFKLMKRLNTEWGELESLVLKDMSDGFISNMTIQRQFFPNDEDQTGAAKALLRLQDTYNLDTDTLSRGNLPGVKHKSFLTAEDCFELGKIAYTEADYYHTELWMEQALKQLDEGEVSSADKVYILDYLSYAVYQQGDLSKAMMLTKRLLELDPEHQRANGNMKYFEYIMAKEKEANKSSTDAEDQTEKETEVKKKDYLPERRKYEMLCRGEGLKMTPRRQKRLFCRYYDGNRNPRYILGPVKQEDEWDKPRIVRFLDIISDEEIETVKELAKPRLRRATISNPITGALETAHYRISKSAWLSGYESPVVSRINTRIQDLTGLDVSTAEELQVANYGVGGQYEPHFDFARKDEPDAFKELGTGNRIATWLFYMSDVSAGGATVFPEVGASVWPKKGTAVFWYNLFPSGEGDYSTRHAACPVLVGNKWVSNKWLHERGQEFRRPCTLSELEFPFLSHPSSTVGFLAKWLSIPLGWEQELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YCH2</accession>
    <name>A0A8C2YCH2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial inner membrane protease subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">IMP2-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">IMMP2L</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterodimer of 2 subunits, IMMPL1 and IMMPL2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S26 family. IMP2 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2YCH2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005022881.1">
        <property type="protein sequence ID" value="ENSCJPP00005016258.1"/>
        <property type="gene ID" value="ENSCJPG00005013381.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00550000075044"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042720">
        <property type="term" value="C:mitochondrial inner membrane peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008015">
        <property type="term" value="P:blood circulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061300">
        <property type="term" value="P:cerebellum vasculature development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033108">
        <property type="term" value="P:mitochondrial respiratory chain complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001541">
        <property type="term" value="P:ovarian follicle development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030728">
        <property type="term" value="P:ovulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006801">
        <property type="term" value="P:superoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.109.10:FF:000045">
        <property type="entry name" value="Inner mitochondrial membrane peptidase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037730">
        <property type="entry name" value="IMP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019758">
        <property type="entry name" value="Pept_S26A_signal_pept_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46041">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46041:SF2">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00761">
        <property type="entry name" value="SPASE_I_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Peptidase S26" evidence="13">
        <location>
            <begin position="42"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005016258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="110" mass="12942" checksum="61EA7BDC0C633FC6" modified="2022-01-19" version="1">MLVQIYTYVYMYAYMSPRNPEQKIIKRVIALEGDIIKTIGYKKKYVKVPHGHIWVEGDHHGHSFDSNAFGPVSLGLLHARATHILWPPKRWQKLQPMLPPERKPLQREQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YCP2</accession>
    <name>A0A8C2YCP2_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Growth hormone regulated TBC protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">GRTP1</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">May act as a GTPase-activating protein for Rab family protein(s).</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2YCP2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005023391.1">
        <property type="protein sequence ID" value="ENSCJPP00005016678.1"/>
        <property type="gene ID" value="ENSCJPG00005013681.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154927"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000027">
        <property type="entry name" value="Growth hormone regulated TBC protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.750:FF:000014">
        <property type="entry name" value="Growth hormone-regulated TBC protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF10">
        <property type="entry name" value="GROWTH HORMONE-REGULATED TBC PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="71"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00043879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005016678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="356" mass="41357" checksum="8041B5A3E126D8E0" modified="2022-01-19" version="1">MAGLEDGREWAYRVDPYGFERPDDFDYASYEAFFSRYLVVLTRRAIKWSKLLKGKNSIQKSLKVKRYIRKGIPNEHRALIWMIVSGAQTNMEQNPGYYQRLLEGEKNDKLVEAIKTDMNRTFPDNVKFRRTADPCLQHTLYNVLVAYGHHNKAVGYCQGMNFIAGYLILITKNEEESFWLLDALIGRILPDYYSPAMLGLKTDQEVLGELVKMKVPAVAELMERHGVMWTLVVSRWFICLFIDILPVEVMTDIPFFSMYIRAYRFLCSTLAVVSYELSSEFSPFLQTVLRIWDCLFYEGSKIIFRVALTLIKQHQAFILEATNFPDICDKFKQITKGTFVTECHTFMQVNAPQPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YFJ6</accession>
    <name>A0A8C2YFJ6_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Glutamate decarboxylase 1</fullName>
            <ecNumber evidence="4">4.1.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">GAD1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the synthesis of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) with pyridoxal 5'-phosphate as cofactor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-glutamate + H(+) = 4-aminobutanoate + CO2</text>
            <dbReference type="Rhea" id="RHEA:17785"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
            <dbReference type="EC" id="4.1.1.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:17786"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.15" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2YFJ6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005031260.1">
        <property type="protein sequence ID" value="ENSCJPP00005022801.1"/>
        <property type="gene ID" value="ENSCJPG00005018089.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155526"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043679">
        <property type="term" value="C:axon terminus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098982">
        <property type="term" value="C:GABA-ergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060077">
        <property type="term" value="C:inhibitory synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048786">
        <property type="term" value="C:presynaptic active zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004351">
        <property type="term" value="F:glutamate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009449">
        <property type="term" value="P:gamma-aminobutyric acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006538">
        <property type="term" value="P:L-glutamate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035641">
        <property type="term" value="P:locomotory exploration behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035176">
        <property type="term" value="P:social behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd06450">
        <property type="entry name" value="DOPA_deC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.170:FF:000003">
        <property type="entry name" value="Glutamate decarboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000016">
        <property type="entry name" value="Glutamate decarboxylase like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021115">
        <property type="entry name" value="Pyridoxal-P_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45677:SF5">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45677">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00392">
        <property type="entry name" value="DDC_GAD_HDC_YDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0530">Neurotransmitter biosynthesis</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7 13" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="13">
        <location>
            <position position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005022801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="613" mass="68926" checksum="4E3E96AE7B237EC0" modified="2022-01-19" version="1">MLRPQVPFSLLPTLSPRGRGDLAARRNGDVGEGTRWGKAGPGRGPTGVPPRQGTPLLSLSAYDSWCGVAHGCTRKIGLKICGFLQRTNSLEDKGRIVGSLKERQSSKNLLACENSEREARFRRTETDFSNLYARDLLPAKNGEEQTMQFLLEVVDILLNYVRKTFDRSTKVLDFHHPHQLLEGMEGFNLELSDNPESLEQILVDCRDTLKYGVRTGHPRFFNQLSTGLDMIGLAGEWLTSTANTNMFTYEIAPVFVLMEQITLRKMREIIGWSNKDGDGIFSPGGAISNMYSIMAARYKYFPEVKTKGMAAVPKLVLFTQNIHYSIKKAGAALGFGTDNVILIKCNERGKIIPADLEAKILEAKQKGYVPLFVNATAGTTVYGAFDPIQEIADICEKYNLWLHVDAAWGGGLLIANSVTWNPHKMMGVLLQCSAILVREKGILQGCNQMCAGYLFQQDKQYDVSYDTGDKAIQCGRHVDIFKFWLMWKAKGTVGFENQVNKCLELAEYLYTKIKNREEFEMVFEGEPEHTNVCFWYIPPSLRGMPDCDERREKLHRVAPKIKALMMESGTTMVGYQPQGDKVNFFRMVISNPAATKSDIDFLIEEIERLGQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SLN2</accession>
    <name>A0A8C2SLN2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">H/ACA ribonucleoprotein complex non-core subunit NAF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">NAF1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">RNA-binding protein required for the maturation of box H/ACA snoRNPs complex and ribosome biogenesis. During assembly of the H/ACA snoRNPs complex, it associates with the complex and disappears during maturation of the complex and is replaced by NOLA1/GAR1 to yield mature H/ACA snoRNPs complex. Probably competes with NOLA1/GAR1 for binding with DKC1/NOLA4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">During assembly of the complex, component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs) which contains NOLA2/NHP2, NOLA3/NOP10, NAF1 and DKC1/NOLA4. Interacts directly with DKC1/NOLA4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAF1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015716457.1">
        <property type="nucleotide sequence ID" value="XM_015860971.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015716458.1">
        <property type="nucleotide sequence ID" value="XM_015860972.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SLN2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005001088.1">
        <property type="protein sequence ID" value="ENSCJPP00005000597.1"/>
        <property type="gene ID" value="ENSCJPG00005000691.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107313052"/>
    <dbReference type="KEGG" id="cjo:107313052"/>
    <dbReference type="CTD" id="92345"/>
    <dbReference type="GeneTree" id="ENSGT00390000004697"/>
    <dbReference type="OrthoDB" id="21550at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000493">
        <property type="term" value="P:box H/ACA snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032212">
        <property type="term" value="P:positive regulation of telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905323">
        <property type="term" value="P:telomerase holoenzyme complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090669">
        <property type="term" value="P:telomerase RNA stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.230:FF:000002">
        <property type="entry name" value="H/ACA ribonucleoprotein complex non-core subunit NAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.230">
        <property type="entry name" value="Probable tRNA pseudouridine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038664">
        <property type="entry name" value="Gar1/Naf1_Cbf5-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007504">
        <property type="entry name" value="H/ACA_rnp_Gar1/Naf1"/>
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    <dbReference type="InterPro" id="IPR040309">
        <property type="entry name" value="Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31633">
        <property type="entry name" value="H/ACA RIBONUCLEOPROTEIN COMPLEX NON-CORE SUBUNIT NAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31633:SF1">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX NON-CORE SUBUNIT NAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04410">
        <property type="entry name" value="Gar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="37"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="258"/>
            <end position="388"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="421"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="100"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="123"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="258"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="286"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="315"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="338"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="423"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00057529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00063185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005000597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="444" mass="49275" checksum="6F7A9CD0C3C84655" modified="2022-01-19" version="1">MPPARYAVGWPETTWGAVMAAQQEVLERLLTLTVEPSSVAEAPGVEEGEQRSANSPGPPDSEKGGPDQPPIAEGTCPSTPPTEAPGEHAASDSESDTDSDSSSTTSSSSSSPSVVSDDDDDHPNEKDNRTHCVRTKDELPLDELPPVEDLNVILPDNVELKLFGTVSSIIEQLVIIESLRGLPPINEESIIFKEDRQAAGKVFEVFGPVQHPFYVLRFNSSEHIKARGINVKDNMYFAPSVEDFTQYIFAEKLQQEKGSDASWKNDQEPPPEALDFSDDEKEREAKQKKKKPQNQGRKKVKTDTNASSEYKGLNQPVQQPASSYSRGYHGRRFSGDPFPSPSGPPGFPRPPIRPPHLYSSDSRIHQESPVFPQPHRKEHPMMQQYPFPPPVFGSVNEMHQFHLPPSNPNMIWTGPNMYNSYPFLPPPQPPPPPPPDSHPQFRPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SMD4</accession>
    <name>A0A8C2SMD4_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Adenylate cyclase type 1</fullName>
            <ecNumber evidence="15">4.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">ADCY1</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>ATP = 3',5'-cyclic AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15389"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <dbReference type="EC" id="4.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="17">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="17">Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15 18">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.1" evidence="15"/>
    <dbReference type="RefSeq" id="XP_032298432.1">
        <property type="nucleotide sequence ID" value="XM_032442541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SMD4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005000046.1">
        <property type="protein sequence ID" value="ENSCJPP00005000018.1"/>
        <property type="gene ID" value="ENSCJPG00005000050.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107309766"/>
    <dbReference type="KEGG" id="cjo:107309766"/>
    <dbReference type="CTD" id="107"/>
    <dbReference type="GeneTree" id="ENSGT00940000154872"/>
    <dbReference type="OrthoDB" id="6147412at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098839">
        <property type="term" value="C:postsynaptic density membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098685">
        <property type="term" value="C:Schaffer collateral - CA1 synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007409">
        <property type="term" value="P:axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007616">
        <property type="term" value="P:long-term memory"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0150076">
        <property type="term" value="P:neuroinflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900273">
        <property type="term" value="P:positive regulation of long-term synaptic potentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099171">
        <property type="term" value="P:presynaptic modulation of chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042752">
        <property type="term" value="P:regulation of circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000001">
        <property type="entry name" value="Adenylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000002">
        <property type="entry name" value="Adenylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032628">
        <property type="entry name" value="AC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030672">
        <property type="entry name" value="Adcy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45627">
        <property type="entry name" value="ADENYLATE CYCLASE TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45627:SF26">
        <property type="entry name" value="ADENYLATE CYCLASE TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16214">
        <property type="entry name" value="AC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039050">
        <property type="entry name" value="Ade_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 15" id="KW-0115">cAMP biosynthesis</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14 15 18" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 15 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="17" id="KW-0464">Manganese</keyword>
    <keyword evidence="12 15 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 15 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 15 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="172"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="618"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="646"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="685"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="737"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="764"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="20">
        <location>
            <begin position="313"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="20">
        <location>
            <begin position="879"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="318"/>
            <end position="323"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="360"/>
            <end position="362"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="362"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="362"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="931"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="1008"/>
            <end position="1010"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="1015"/>
            <end position="1019"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="1055"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR039050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR039050-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR039050-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005000018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1142" mass="128315" checksum="9A92FA4D8F3FB9B7" modified="2022-01-19" version="1">MNGNDMEEIPFHKVKTKRKKCFHCCCSSPAAAVAGAGARLGEPPPLLLLDAIACEDEFDCKELESLFQSYNLKLEQKSTLKALAVLIVLTASLALVELLSGPSLTISKGSHPVHCIIFLSLFIVTNVKYLQVTQLQQIVKLTLLFSFTFSFLCCPFSLGAYGMEPPSAPEQGMWQLMLVTFVSYSLLPVRTLLAIVFGLVVSVSHLIVTATSVSAKRQRLWRTLVANAILFVSVNLYGVFVRILTERAQRKAFLQARNCIEDRLRLEDENEKQERLLMSLLPRNVAMEMKEDFLKPPERIFHKIYIQRHDNVSILFADIVGFTSLASQCTAQELVKLLNELFGKFDELATENHCRRIKILGDCYYCVSGLTQPKTDHAHCCVEMGLDMIDTITSVAEATEVDLNMRVGLHTGRVLCGVLGLRKWQYDVWSNDVTLANVMEAGGLPGKVHITKTTLECLNGDYEVEPGYGHERNSFLKKHNIETYFIVPSHRRKIFPGLILSDIKPAKRMKFKTVCYLLVQLMHCRKMFKAEIPFSNVMTCEDDDKRRALRTASEKLRNRSSFSTNVVYNTPGTRVNRYISRLIEARQTESEMADLNFFTLKYKQIEREKKYHQLQDEYFTSAVVLSLILAALFGLVYLLIIPQSTVVLVLLVFCICFLVACIMYLHVTRVQCFPGCLTIQIRTILCIFIVILIYSVAQGCVVGCMPWVWNTNSSSSIVIISPGGTNKTMNELPCDTAHYAFLSCVVGTLTLAIFLRVSSLPKIILLLFVTILYIVILELSGYRKAVGGGSFYMRGYEPTLAILLFSCALALHSRQVDLKLRLDYLWAVQAEEERDDMERVKLDNKRILFNLLPAHVAQHFLMSNPRNMDLYYQSYSQVGVMFASIPNFNDFYIELDGNNMGVECLRLLNEIIADFDELMEKECYKDIEKIKTIGSTYMAAVGLVPTSGTKAKKSIYSHLSTLADFAIEMFDVLDEINYQSYNDFVLRVGINVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVQGKIQVTEEVQRILKRCSYEFVCRGKVSVKGKGEMLTYLLEGKANGNNSQTQSLNVERKMYPYGRANVQTKLGTSCPSVSSVASFTPKAGPGADQVSTTHANQTLHYLPSVPAVKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SNL5</accession>
    <name>A0A8C2SNL5_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADH dehydrogenase [ubiquinone] iron-sulfur protein 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Complex I-15 kDa</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">NADH-ubiquinone oxidoreductase 15 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">NDUFS5</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I NDUFS5 subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SNL5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005002396.1">
        <property type="protein sequence ID" value="ENSCJPP00005001444.1"/>
        <property type="gene ID" value="ENSCJPG00005001463.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000002919"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd24141">
        <property type="entry name" value="NDUFS5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019342">
        <property type="entry name" value="NADH_UbQ_OxRdtase_FeS-su5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15224">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15224:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10200">
        <property type="entry name" value="Ndufs5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="78"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="89"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="33"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="43"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR619342-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005001444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="112" mass="12925" checksum="E845D057146E7765" modified="2022-01-19" version="1">MPFWDLQRQLGIDVDRWLLRQSTTQPYGMAGACHAFEREWVECGHGLGQTRAQRECQPEYQDFMECMHRTKTWLRRMRAVSAAAPTPPAHNNDSPSPCSKTTRGLNPDLQHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SRG4</accession>
    <name>A0A8C2SRG4_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Plexin domain containing 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PLXDC1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the plexin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015741438.1">
        <property type="nucleotide sequence ID" value="XM_015885952.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SRG4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005003876.1">
        <property type="protein sequence ID" value="ENSCJPP00005002175.1"/>
        <property type="gene ID" value="ENSCJPG00005002330.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107325265"/>
    <dbReference type="KEGG" id="cjo:107325265"/>
    <dbReference type="CTD" id="57125"/>
    <dbReference type="GeneTree" id="ENSGT00440000033408"/>
    <dbReference type="OrthoDB" id="6285106at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002165">
        <property type="entry name" value="Plexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031152">
        <property type="entry name" value="PLXDC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13055:SF10">
        <property type="entry name" value="PLEXIN DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13055">
        <property type="entry name" value="TUMOR ENDOTHELIAL MARKER 7 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01437">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034488549" evidence="10">
        <location>
            <begin position="18"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="327"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005002175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="469" mass="51611" checksum="A8DD88C9A25C9CE1" modified="2022-01-19" version="1">MLGGFLILLGFIALCGARGAGPPEGQPQGTHISQDLVGRSLVIDTLLDNETRIVEDNHSYYVSRTYGPGAARRMGLWVDMAAADSSHVKVHGILSNTHRQASRIVLSFDFPFYGHLLRQVTIATGGFIFMGDVIHRMLTATQYIAPLMANFNPSYSRNSTVQYLDNGTVFVVQWDKVYLQGKEDVGSFTFQAALHSSGRIVFGYKEIPVPVLQISAAQHPVKAGLSDAFMVLNPSPEVPESRRRTIYEYHRVELDTSKITNMSAVEFTPLPTCLQHRSCEVCVSSTLTFNCSWCHVLQRCSSGFDRHREEWLSYGCAQQADAKSCEDLAEDDQYSPPPDGSSSPLDEDITTPTASLFIDSLTTEDDTKLNQHAGSEGVGSDLPSNEVGAPIHTGTIVGIVLAVLLIAAIILAGIYINSHPTSNAALFFIERRPHRWPAMKFRNHSNHTTYSEVEAASHEKESFVEAEQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SRK9</accession>
    <name>A0A8C2SRK9_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SERTA domain-containing protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC107315323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="Ensembl" id="ENSCJPT00005005091.1">
        <property type="protein sequence ID" value="ENSCJPP00005002758.1"/>
        <property type="gene ID" value="ENSCJPG00005003052.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063867"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052262">
        <property type="entry name" value="E2F-SERTA_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009263">
        <property type="entry name" value="SERTA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16277">
        <property type="entry name" value="CELL DIVISION CYCLE ASSOCIATED PROTEIN 4/SERTA DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16277:SF16">
        <property type="entry name" value="SERTA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06031">
        <property type="entry name" value="SERTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51053">
        <property type="entry name" value="SERTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SERTA" evidence="1">
        <location>
            <begin position="19"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005002758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="221" mass="24573" checksum="1B25E7C4DF002D37" modified="2022-01-19" version="1">MLGRGLKRKLSDYEENMAGLSSRQLVLNMCLTKLQTYKMLVEPNLHRSVLIANTVQQESNCCDLRSAEDPIENSLLIVSDDDMSSAISSILKDLDFVEDISPPTCLVPTGDDQPKFPENPSLKLEDDXXXXECVFGSFEISNSTSYLKDLAIDDIFEDIDTSMYDSDFCCPPLMSPRPTPLATEEPLKTFPTCNSSSANNIQICRTDLSELDHIMEILVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SSK6</accession>
    <name>A0A8C2SSK6_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transmembrane protein 184C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TMEM184C</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SSK6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005005723.1">
        <property type="protein sequence ID" value="ENSCJPP00005003176.1"/>
        <property type="gene ID" value="ENSCJPG00005003414.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155201"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="350"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="383"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="406"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005003176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="424" mass="48777" checksum="7AE054D38EA184DC" modified="2022-01-19" version="1">MKEGFFWIRSRVTYWAIYLLVTRICITENSILESFLFYFLTVPQLEPSYPFETGRFKLQKPIIRILWMEPIYSLDSWIALKYPNIAIYVDTCRECYEAYVIYNFMVFLSNYLTNRYPNLVLIIEAKDQQRHLTPLCCCPSWAMGEVLLFRCKLGVLQYTVVRPFTTIIALICELVGVYDEGNFSFDNAWTYLVILNKMSQLFAMYCLVLFYKVLREELNPIQPVGKFLCVKMVVFVSFWQAVLIALLVKVGVISEKHTWEWQSVEAVATGLQDFIICVEMFLAAIAHHYSFSYKPYVQEAEEGSCFDSFLAMWDISDIRADISEQVRNVGRTVLGQPRKMFFAEDHEQNEHTSLLSSSTQDPISDASSMPSSPMGHYQGFGHTVTPLTTPTTVPAVDGIYNSSATRDTEESPEHSSSEKALDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2ST96</accession>
    <name>A0A8C2ST96_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transcription factor TFIIB cyclin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIB family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2ST96"/>
    <dbReference type="Ensembl" id="ENSCJPT00005005154.1">
        <property type="protein sequence ID" value="ENSCJPP00005002790.1"/>
        <property type="gene ID" value="ENSCJPG00005003091.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000010349"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000126">
        <property type="term" value="C:transcription factor TFIIIB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000995">
        <property type="term" value="F:RNA polymerase III general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20554">
        <property type="entry name" value="CYCLIN_TFIIIB90_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000002">
        <property type="entry name" value="Transcription factor IIIB 90 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618:SF4">
        <property type="entry name" value="TRANSCRIPTION FACTOR IIIB 90 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Transcription factor TFIIB cyclin-like" evidence="10">
        <location>
            <begin position="2"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="103"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005002790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="166" mass="19241" checksum="3B8843A2211FD0A4" modified="2022-01-19" version="1">MTALRLLQRMKRDWMHTGRRPSGLCGAALLVAARMHDFRRTVKEVIRVVKVCESTLRKRLTEFEYTPTSQLTIDEFMRIDLEEECDPPSFTAGQKKLKIQQLEKALSKKLEDFEGEISSYQDEIEIELENSRPKAKGVFANLSKSGKSIKSCDYLNNNRFVSCRQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2STK4</accession>
    <name>A0A8C2STK4_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Interleukin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC107313531</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the IL-15/IL-21 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2STK4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005005488.1">
        <property type="protein sequence ID" value="ENSCJPP00005003039.1"/>
        <property type="gene ID" value="ENSCJPG00005003281.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000235552"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005126">
        <property type="term" value="F:cytokine receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042119">
        <property type="term" value="P:neutrophil activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001819">
        <property type="term" value="P:positive regulation of cytokine production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050778">
        <property type="term" value="P:positive regulation of immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042102">
        <property type="term" value="P:positive regulation of T cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.70">
        <property type="entry name" value="Interleukin-15/Interleukin-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009079">
        <property type="entry name" value="4_helix_cytokine-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003443">
        <property type="entry name" value="IL-15/IL-21_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14356:SF3">
        <property type="entry name" value="INTERLEUKIN-15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14356">
        <property type="entry name" value="INTERLEUKIN-15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02372">
        <property type="entry name" value="IL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47266">
        <property type="entry name" value="4-helical cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0202">Cytokine</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034403021" description="Interleukin" evidence="8">
        <location>
            <begin position="22"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005003039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="142" mass="16364" checksum="015D5C7364C3FAFE" modified="2022-01-19" version="1">MCKVLIFACISVAMLMTTAYGATLPPKEQDILPTLISDLELLEKSKNKIHLELYTPSETQECIHQTLQCYQKEIITLRKEIEDEPEIENKVRTALQHIENNLDTLMEQTPIGGECKICEANDKKSFPDFHQKLTDFLRSMHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SU64</accession>
    <name>A0A8C2SU64_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Fucosyltransferase</fullName>
            <ecNumber evidence="18">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">FUT4</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Catalyzes alpha(1-&gt;3) linkage of fucosyl moiety transferred from GDP-beta-L-fucose to N-acetyl glucosamine (GlcNAc) within type 2 lactosamine (LacNAc, Gal-beta(1-&gt;4)GlcNAc) glycan attached to N- or O-linked glycoproteins. Robustly fucosylates nonsialylated distal LacNAc unit of the polylactosamine chain to form Lewis X antigen (CD15), a glycan determinant known to mediate important cellular functions in development and immunity. Fucosylates with lower efficiency sialylated LacNAc acceptors to form sialyl Lewis X and 6-sulfo sialyl Lewis X determinants that serve as recognition epitopes for C-type lectins. Together with FUT7 contributes to SELE, SELL and SELP selectin ligand biosynthesis and selectin-dependent lymphocyte homing, leukocyte migration and blood leukocyte homeostasis. In a cell type specific manner, may also fucosylate the internal LacNAc unit of the polylactosamine chain to form VIM-2 antigen that serves as recognition epitope for SELE.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a beta-D-galactosyl-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose = a beta-D-galactosyl-(1-&gt;4)-[alpha-L-fucosyl-(1-&gt;3)]-N-acetyl-beta-D-glucosaminyl derivative + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14257"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:133507"/>
            <dbReference type="ChEBI" id="CHEBI:137941"/>
            <dbReference type="EC" id="2.4.1.152"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:14258"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>an N-acetyl-alpha-neuraminyl-(2-&gt;3)-beta-D-galactosyl-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose = an alpha-Neu5Ac-(2-&gt;3)-beta-D-Gal-(1-&gt;4)-[alpha-L-Fuc-(1-&gt;3)]-beta-D-GlcNAc derivative + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:56076"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:136545"/>
            <dbReference type="ChEBI" id="CHEBI:139509"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:56077"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>an alpha-Neu5Ac-(2-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-GlcNAc derivative + GDP-beta-L-fucose = an alpha-Neu5Ac-(2-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-[alpha-L-Fuc-(1-&gt;3)]-beta-D-GlcNAc derivative + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:68044"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:145343"/>
            <dbReference type="ChEBI" id="CHEBI:176900"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:68045"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>an alpha-Neu5Ac-(2-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-GlcNAc6S derivative + GDP-beta-L-fucose = an alpha-Neu5Ac-(2-&gt;3)-beta-D-Gal-(1-&gt;4)-[alpha-L-Fuc-(1-&gt;3)]-beta-D-GlcNAc6S derivative + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:62004"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:145344"/>
            <dbReference type="ChEBI" id="CHEBI:145345"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:62005"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Golgi apparatus</location>
            <location evidence="18">Golgi stack membrane</location>
            <topology evidence="18">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the glycosyltransferase 10 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="18"/>
    <dbReference type="RefSeq" id="XP_015707787.2">
        <property type="nucleotide sequence ID" value="XM_015852301.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SU64"/>
    <dbReference type="Ensembl" id="ENSCJPT00005006689.1">
        <property type="protein sequence ID" value="ENSCJPP00005003857.1"/>
        <property type="gene ID" value="ENSCJPG00005003953.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107308429"/>
    <dbReference type="KEGG" id="cjo:107308429"/>
    <dbReference type="CTD" id="2526"/>
    <dbReference type="GeneTree" id="ENSGT00940000162506"/>
    <dbReference type="OrthoDB" id="427096at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017083">
        <property type="term" value="F:4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097022">
        <property type="term" value="P:lymphocyte migration into lymph node"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903238">
        <property type="term" value="P:positive regulation of leukocyte tethering or rolling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902624">
        <property type="term" value="P:positive regulation of neutrophil migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11660:FF:000001">
        <property type="entry name" value="alpha-(1,3)-fucosyltransferase 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11660">
        <property type="entry name" value="Glycosyl transferase family 10, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055270">
        <property type="entry name" value="Glyco_tran_10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031481">
        <property type="entry name" value="Glyco_tran_10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001503">
        <property type="entry name" value="Glyco_trans_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038577">
        <property type="entry name" value="GT10-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11929">
        <property type="entry name" value="ALPHA- 1,3 -FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11929:SF132">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17039">
        <property type="entry name" value="Glyco_tran_10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00852">
        <property type="entry name" value="Glyco_transf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 18" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 18" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12" id="KW-0395">Inflammatory response</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fucosyltransferase N-terminal" evidence="21">
        <location>
            <begin position="215"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosyltransferase C-terminal" evidence="20">
        <location>
            <begin position="338"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="47"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="19">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
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            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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            <dbReference type="ARBA" id="ARBA00023180"/>
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            <dbReference type="ARBA" id="ARBA00023198"/>
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            <dbReference type="ARBA" id="ARBA00029329"/>
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            <dbReference type="ARBA" id="ARBA00046186"/>
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    <evidence type="ECO:0000256" key="18">
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            <dbReference type="RuleBase" id="RU003832"/>
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    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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    <evidence type="ECO:0000259" key="20">
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            <dbReference type="Pfam" id="PF00852"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF17039"/>
        </source>
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        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005003857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="515" mass="57694" checksum="86883FC37F4BC6D9" modified="2022-01-19" version="1">MGHQKPHGKECPSATAEPLRLPGAGCEGRGEQRCRHIAAVIWAVPGSLPLPEAAPRAPSGGVEGRAGAGAGRRDGRPRGVSGRSGMAGRGCSSISPPLPGGSAPPCAVPGQGVGAERRRRQQQQQQQQQQQQQQQQQQQQHAPGGPGPASPPGWQRAAWMESGPRRIPASRPGCPRRWRRRWALLGALLGSALALYGCLRELRRGGSAPGRPEGDVTVLLWWEPFGRPRRPPDCRRRYNITGCRLSADRGRYGEARAVLFHHRDLALHGAQGLPRGTPPRPPRQLWVWMNFESPSHSPGLRGLAGLFNWTMSYRRDSDVFVPYGYLYASPSPRPFVVPRKSRLVAWVISNWNEEHARVRYYRQLKEHLPIDVYGARGMALLEGSVVKTVSAYKFYLAFENSQHTDYITEKLWRNAFAASAVPVVLGPRRANYERFIPADSFIHVDDFPSPRLLATYLKFLDKNKPSYRRYFAWRNKYEVHVTSFWDEHYCKVCEAVRTAGNQLKTVQNLASWFES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SUL4</accession>
    <name>A0A8C2SUL4_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Androgen receptor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Dihydrotestosterone receptor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Nuclear receptor subfamily 3 group C member 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">AR</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 18">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the nuclear hormone receptor family. NR3 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015715505.1">
        <property type="nucleotide sequence ID" value="XM_015860019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SUL4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005004985.1">
        <property type="protein sequence ID" value="ENSCJPP00005002685.1"/>
        <property type="gene ID" value="ENSCJPG00005002994.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107312515"/>
    <dbReference type="KEGG" id="cjo:107312515"/>
    <dbReference type="CTD" id="367"/>
    <dbReference type="GeneTree" id="ENSGT00940000155516"/>
    <dbReference type="OrthoDB" id="10032732at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005497">
        <property type="term" value="F:androgen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140693">
        <property type="term" value="F:molecular condensate scaffold activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003707">
        <property type="term" value="F:nuclear steroid receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070974">
        <property type="term" value="F:POU domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000979">
        <property type="term" value="F:RNA polymerase II core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001091">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061629">
        <property type="term" value="F:RNA polymerase II-specific DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005496">
        <property type="term" value="F:steroid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001223">
        <property type="term" value="F:transcription coactivator binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030521">
        <property type="term" value="P:androgen receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048645">
        <property type="term" value="P:animal organ formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071391">
        <property type="term" value="P:cellular response to estrogen stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071394">
        <property type="term" value="P:cellular response to testosterone stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003382">
        <property type="term" value="P:epithelial cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050673">
        <property type="term" value="P:epithelial cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030520">
        <property type="term" value="P:estrogen receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048009">
        <property type="term" value="P:insulin-like growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033327">
        <property type="term" value="P:Leydig cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048808">
        <property type="term" value="P:male genitalia morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019102">
        <property type="term" value="P:male somatic sex determination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000165">
        <property type="term" value="P:MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140694">
        <property type="term" value="P:membraneless organelle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060571">
        <property type="term" value="P:morphogenesis of an epithelial fold"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035264">
        <property type="term" value="P:multicellular organism growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050680">
        <property type="term" value="P:negative regulation of epithelial cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001237">
        <property type="term" value="P:negative regulation of extrinsic apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045597">
        <property type="term" value="P:positive regulation of cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043568">
        <property type="term" value="P:positive regulation of insulin-like growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045726">
        <property type="term" value="P:positive regulation of integrin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033148">
        <property type="term" value="P:positive regulation of intracellular estrogen receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902895">
        <property type="term" value="P:positive regulation of miRNA transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045945">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048638">
        <property type="term" value="P:regulation of developmental growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903076">
        <property type="term" value="P:regulation of protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003073">
        <property type="term" value="P:regulation of systemic arterial blood pressure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072520">
        <property type="term" value="P:seminiferous tubule development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007338">
        <property type="term" value="P:single fertilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd07173">
        <property type="entry name" value="NR_DBD_AR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07073">
        <property type="entry name" value="NR_LBD_AR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000024">
        <property type="entry name" value="Androgen receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.565.10:FF:000004">
        <property type="entry name" value="Androgen receptor variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001103">
        <property type="entry name" value="Andrgn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050200">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48092">
        <property type="entry name" value="KNIRPS-RELATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02166">
        <property type="entry name" value="Androgen_recep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00521">
        <property type="entry name" value="ANDROGENR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12 18" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="7 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15 18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14 18" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0754">Steroid-binding</keyword>
    <keyword evidence="13 18" id="KW-0804">Transcription</keyword>
    <keyword evidence="10 18" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9 18" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 18" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="20">
        <location>
            <begin position="340"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="21">
        <location>
            <begin position="452"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="37"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="161"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="19">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005002685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="703" mass="77053" checksum="DA3F45EA31BCFAB3" modified="2022-01-19" version="1">MEVQLGIGRMYPRPPGRTFRGAFQTFFQSVCEAFQAPRDEPGPGLPAPGAPCPQSPRPPPVSSPSFLPLPEPCAAARPAMGSPFPCTGDLKELLGEPGALPLLPPEAEPGAGRAEPAPKEDFLGDSAKELCKAVSVSMGLAVEGLEAPREPPPREDCMFALPGGPPRAPRPDAAEPPEQPAPAAFKSSGAEAALAVEVPAGLPLYRVSPPPEEPPGRDCFVLPPPARIKLESPPEPAAIGSWGSPVPAPPWPSFFADEGQLYGPCAEPPPGAFGCVRAENADFAADAWYPMARAPYSAPGSCIKSELGPWAEGYAGAYGDVRLEAGREHILPIDYYFPPQKTCLICGDEASGCHYGALTCGSCKVFFKRAAEGKQKYLCASRNDCTIDKFRRKNCPSCRLRKCYEAGMTLGARKVKKLGSLKTQDEAEAASSSSPTEEQAPKMAMTHIGGFECQPIFLNVLEAIEPAVVCAGHDNSQPDSFSNLLSSLNELGERQLVYVVKWAKALPGFRNLHVDDQMSIIQYSWMGLMIFAMGWRSFTNVNSRMLYFAPDLVFNEYRMHKSRMYSQCIRMRQLSQEFGWLQITPQEFLCMKALLFFSIIPVDGLKNQKLFDELRMNYIKELDRIIACKRKNPTSCSRRFYQLTKVLDSVHPIAKDLHQFTFDLLIKAHMVSVDYPEMMAEIISVQVPKILSGKVKPIYFHAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SUV4</accession>
    <name>A0A8C2SUV4_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Solute carrier family 22 member 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">SLC22A7</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SUV4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005007064.1">
        <property type="protein sequence ID" value="ENSCJPP00005004157.1"/>
        <property type="gene ID" value="ENSCJPG00005004194.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154922"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015139">
        <property type="term" value="F:alpha-ketoglutarate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015132">
        <property type="term" value="F:prostaglandin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd17447">
        <property type="entry name" value="MFS_SLC22A7_OAT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="335"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005004157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="510" mass="57041" checksum="297AE28BEAA7F0E1" modified="2022-01-19" version="1">MKFEDLLLETGGFGRFQILILLILCLPRINLPMHFLLHNFLAATPSHHCAIPHQEGFVNLSTEEILLISIPREPDGTFSSCEMFSQPQFHLLLNSSLQPDNDSVTQDCQHGWVYDHSQFTSTISTEWDLVCEQRGLNQATATFFFIGVTMGAVVFGYLSDRFDPPRLQGLASQVLFGMLSACSVSYTMLAVTRTLTGVALSGVSLIILPLGMEWVDIEHRTFSGVLTSIFWSVGNMLLALTAYLVREWHWLLVAVTGPCLLSIICLWWVPESARWLIANGKVKQAHKHLLRCARMNGRKDFTVSPEVLRGMTTEKKPSESFSYISLFRTPVLRKISLCSGTVWFGVAFSYYGMSMNLTGFGLNMYFSQFVFGIIEIPAKILMYVLVNRIGRRHSQAWSLILTGLSFTSLRSVIAIMAKGSSEAAFTTVYLYTSELYPTVLRQNGMGYTSFMARLGGSLAPLVFLLDDVWRSLPEVTYCGVAVFCGSVAFLLPETLNVRLPEGIEDIEKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SVK5</accession>
    <name>A0A8C2SVK5_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">POU domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">POU2F1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the POU transcription factor family. Class-2 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SVK5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005005585.1">
        <property type="protein sequence ID" value="ENSCJPP00005003081.1"/>
        <property type="gene ID" value="ENSCJPG00005001172.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157831"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
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        <property type="entry name" value="HD"/>
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        <property type="entry name" value="POU DOMAIN, CLASS 2, TRANSCRIPTION FACTOR 1"/>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="OCTAMER"/>
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        <property type="entry name" value="POUDOMAIN"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="4 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 9 10" id="KW-0371">Homeobox</keyword>
    <keyword evidence="8 9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="POU-specific" evidence="14">
        <location>
            <begin position="301"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="13">
        <location>
            <begin position="400"/>
            <end position="460"/>
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    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="9">
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            <begin position="402"/>
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            <begin position="25"/>
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    <sequence length="786" mass="81583" checksum="5514C0ADE5D5BD36" modified="2022-01-19" version="1">NRSSHLLLYDKSSAFVLNRCAYSRMNNPSETSKPSMESGDGNTGTQTNGLDFQKQPVPVGGPISTAQAQAFLGHLHQVQLAGTSLQAAAQSLNVQSKSNEESGDSQQPSQPSQQPSVQAAIPQTQLMLAGGQITGLTLTPAQQQLLLQQAQAQLLAAAVQHSASQQHSAAGATISASAATPMTQIPLSQPIQIAQDLQHLQQLQQQNLNLQQFVLVHPTTNLQPAQFIISQTPQGQQGLLQAQNLLTQLPQQSQANLLQSQPSITLASQPATPTRTIAATPIQPLPQSQSTPKRIDTPSLEEPSDLEELEQFAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWLNDAENLSSDSTLSSPSALNSPGQGIEGVNRRRKKRTSIETNIRVALEKSFLENQKPTSEEITMIADQLNMEKEVIRVWFCNRRQKEKRINPPSSGGTSSSPIKAIFPCPTSLVATTPSLVTSSAATTLTVNPVLPLTSPAVTSLSVTGKGFIWEKFRTLWDLLLNLLGTTETTSNNTATVISTAPPASSAVTSPSLSPSPSASASISEASSASETSTTQTTSTPLSSPLGTSQVMVTASGLQTAAAAALQGAAQLPANASLAAMAAAAGLNPGLMASSQFAAGGALLSLNPGTLGGALSPALMSNSTLATIQALASSGSLPITSLDASGNLVFANAGGTPNIVTAPLFLNPQNLSLLTSNPVSLVSAAAASAGASGPVASLHATSTSAESIQNSLLTVASASGATSTTTTASKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SW73</accession>
    <name>A0A8C2SW73_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Opsin-VA-like</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SW73"/>
    <dbReference type="Ensembl" id="ENSCJPT00005007087.1">
        <property type="protein sequence ID" value="ENSCJPP00005004179.1"/>
        <property type="gene ID" value="ENSCJPG00005004208.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234549"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016037">
        <property type="term" value="P:light absorption"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007602">
        <property type="term" value="P:phototransduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15082">
        <property type="entry name" value="7tmA_VA_opsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000238">
        <property type="entry name" value="Opsin-VA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050125">
        <property type="entry name" value="GPCR_opsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001760">
        <property type="entry name" value="Opsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002206">
        <property type="entry name" value="Opsin_pineal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027430">
        <property type="entry name" value="Retinal_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24240">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00238">
        <property type="entry name" value="OPSIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00666">
        <property type="entry name" value="PINOPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00238">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0157">Chromophore</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 13" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 13" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="11 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0681">Retinal protein</keyword>
    <keyword evidence="3 13" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="12 13" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="35"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="105"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="153"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="54"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005004179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="384" mass="42722" checksum="C6F147354F2D40BF" modified="2022-01-19" version="1">MDVVRALGNESLLSNSSGPAAWDPFRRPLDSIQPWHFRLVAAVMFVVTSVSLAENLAVILVTAKFKQLRQPVNYVIVNLSVADFLVSLTGGTISFLANLKGYFYMGHWACVLEGFAVTFFGIVSLWSLALLAFERYVVICRPLGNTRLRGKHAAQGIAFVWTFSFIWTIPPTMGWSSYTTSKIGTTCEPNWYSGAHNDRSYIIAFFTTCFIVPLLVILVSYGKLLHKLTKVSDTQGRLRTARKPERQVTRMVVVMIIAFLICWMPYATFSILATAYPSVELDPHLAAVPAFFSKTATVYNPVIYVFMNKQFRKCLMQMSRCGAIATVGSNVKPASVRAVLTQDKRGSQLSIMAEGDMIINAVWQRVSSLPIMLKVSLGLLRSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SWM6</accession>
    <name>A0A8C2SWM6_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ras association domain-containing protein 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">PAM COOH-terminal interactor protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Peptidylglycine alpha-amidating monooxygenase COOH-terminal interactor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">RASSF9</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">May play a role in regulating vesicuar trafficking in cells.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Interacts with PAM.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015713033.1">
        <property type="nucleotide sequence ID" value="XM_015857547.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SWM6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005008096.1">
        <property type="protein sequence ID" value="ENSCJPP00005004933.1"/>
        <property type="gene ID" value="ENSCJPG00005004777.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107311208"/>
    <dbReference type="KEGG" id="cjo:107311208"/>
    <dbReference type="CTD" id="9182"/>
    <dbReference type="GeneTree" id="ENSGT00950000182839"/>
    <dbReference type="OrthoDB" id="10034447at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012510">
        <property type="term" value="C:trans-Golgi network transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16133">
        <property type="entry name" value="RA_RASSF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000113">
        <property type="entry name" value="ras association domain-containing protein 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033593">
        <property type="entry name" value="N-RASSF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033633">
        <property type="entry name" value="RASSF9_RA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15286:SF10">
        <property type="entry name" value="RAS ASSOCIATION DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15286">
        <property type="entry name" value="RAS-ASSOCIATING DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0967">Endosome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-associating" evidence="10">
        <location>
            <begin position="25"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00053167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00065441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00073476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00078989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00081630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005004933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="440" mass="50684" checksum="E5449B950ECBA6FA" modified="2022-01-19" version="1">MAPFGRNLLKTRHKNRSPSKDMASNEREIVVWVCQEEKIVCGLTKRTTCAEVIQALLEEHQATFGEKKVLFGKPSDYCIVEKWRGSERVLPPLTKILRLWKAWGEEQPNLHFVLVKSDAFLSFPLWKTAEAKVVQNIEKQWELSPANYMKMLPIDKQKKIVRKTFRKLAKLKQDSVQQDRDNMETLIHLIISQDHTIHQQVLRMKELDMEIEKCEAKFHLDRVANDGENYVQDSYLMINPSEAEQQGSRSDDQKEMNEYFSKSEGILQVEERLKHHKQLIEKLCAEIEKEVHGICSEKNSDVVHTEGATNAQVENSDLDNVKYELEKSMKDGLRINSYLSCIQKELTYRDSLLQKKEKEYELLTEEFNLLHVKDNIEVRLPSNEELPKGSGISSNSIAVPDFVHRVTNLDINDTDSDTGISSTHSQDSEITSGDVVLLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SX91</accession>
    <name>A0A8C2SX91_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Neurotransmitter-gated ion-channel transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SX91"/>
    <dbReference type="Ensembl" id="ENSCJPT00005006594.1">
        <property type="protein sequence ID" value="ENSCJPP00005003777.1"/>
        <property type="gene ID" value="ENSCJPG00005003899.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158661"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="2">
        <location>
            <begin position="287"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005003777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="384" mass="40842" checksum="E22C3B631164AEC4" modified="2022-01-19" version="1">MHVAQGQPFACCLAPTCVAPVQPIAHHLAPIQVAQAQPLAPKHVAPVQPIAQHLAPSHVAPVQPIAHHLTPTRVAPVQPFAHCLTPTRVAPVQSIAHRLTPTCVAPLQPFAQRLAPMHVAQALAPTHVAPVQPFAQCLAPMHIAQAQPLAPKHVAQARCLAPTPFLCRQRPMADRAPCSVAPSQLVAPSRLVARGLPRRRDIRPADPPPAAVLHHQRPRALGAAHAAGRQHLLPAARRRSDLHTRGVCTRVFCTRVFCTRGSCTRGEVAHERNLHTRVFARVSLHEGGEKMTLSLFALLTLTVFLLLLADKVPATSLAVPLIGRYLTGALVLLTLSVTLSVGVLNVHHRAPATHTMPQGMRAVSGGIWGGMGAMGVLNGVARGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SX94</accession>
    <name>A0A8C2SX94_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="8">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PPP5C</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2SX94"/>
    <dbReference type="Ensembl" id="ENSCJPT00005008494.1">
        <property type="protein sequence ID" value="ENSCJPP00005005184.1"/>
        <property type="gene ID" value="ENSCJPG00005005016.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158785"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101031">
        <property type="term" value="C:protein folding chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013235">
        <property type="entry name" value="PPP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051134">
        <property type="entry name" value="PPP_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668:SF5">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08321">
        <property type="entry name" value="PPP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="30"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="10">
        <location>
            <begin position="302"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005005184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="487" mass="54041" checksum="43AA8AA373F9E9BE" modified="2022-01-19" version="1">MAERQRAESGDGPGRHRSPGGNNGLRTRPSRGTKDTANEYFKGKQYEEAVELYSRAIELNPTNAIYYGNRSLAYLRTECYGYALADATRAIELDSKYIKGCYRRAASNMALGKVKAALRDYETVVKVRPNDKDAKLKYQECNKIVKQKAFERAIASDEHKRSVVDSLDIESMTIEDEYSGPKLEGGKVTLSFMQELMQWYKDQKKLHRKCAYQILVQVKEVLSKLPTLVETTLKETEMVTVCGDTHGQFYDLLNIFELNGLPSESNPYIFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLLRGNHETDNMNQIYGFEGEVKAKYTAQMFALFSEVFEWLPLAQCINGKVLVSPFLCPLPLPVPPSSSCAPFLFLCPLPLPVPPSSYGCPFLFRVSLPVLGVPSCSRCPLYVPGVPSCSGCPFLFQVSLPVLGVPSCSGCPFPFWVSHPLPPPYSGCPLPVPGVSSYSGCPLPVPGVPSCSGCPFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SXZ2</accession>
    <name>A0A8C2SXZ2_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nascent polypeptide associated complex subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">NACA</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SXZ2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005007750.1">
        <property type="protein sequence ID" value="ENSCJPP00005004677.1"/>
        <property type="gene ID" value="ENSCJPG00005004582.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000166484"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome LGE22C19W28_E50C23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005854">
        <property type="term" value="C:nascent polypeptide-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22054">
        <property type="entry name" value="NAC_NACA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.30:FF:000002">
        <property type="entry name" value="Nascent polypeptide-associated complex (NAC), alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.30">
        <property type="entry name" value="Nascent polypeptide-associated complex domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016641">
        <property type="entry name" value="EGD2/NACA0like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038187">
        <property type="entry name" value="NAC_A/B_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002715">
        <property type="entry name" value="Nas_poly-pep-assoc_cplx_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21713">
        <property type="entry name" value="NASCENT POLYPEPTIDE ASSOCIATED COMPLEX ALPHA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01849">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01407">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51151">
        <property type="entry name" value="NAC_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAC-A/B" evidence="2">
        <location>
            <begin position="1093"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1177"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="199"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
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        <location>
            <begin position="303"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="420"/>
            <end position="443"/>
        </location>
    </feature>
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        <location>
            <begin position="457"/>
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        </location>
    </feature>
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        <location>
            <begin position="548"/>
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        </location>
    </feature>
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        <location>
            <begin position="665"/>
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        </location>
    </feature>
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        <location>
            <begin position="779"/>
            <end position="794"/>
        </location>
    </feature>
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        <location>
            <begin position="802"/>
            <end position="818"/>
        </location>
    </feature>
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        <location>
            <begin position="826"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="874"/>
            <end position="933"/>
        </location>
    </feature>
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        <location>
            <begin position="949"/>
            <end position="962"/>
        </location>
    </feature>
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        <location>
            <begin position="982"/>
            <end position="994"/>
        </location>
    </feature>
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        <location>
            <begin position="1003"/>
            <end position="1017"/>
        </location>
    </feature>
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        <location>
            <begin position="1025"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1052"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1067"/>
            <end position="1080"/>
        </location>
    </feature>
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        <location>
            <begin position="1195"/>
            <end position="1207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005004677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1257" mass="119231" checksum="F1FBA21FD85E94B8" modified="2022-01-19" version="1">MGVPGGAPPSRTPERPNVTRNFRTRPGTFVRSRRGERTEVCCSLPPEVIVFPEVAPSAAWSLSAAILGSASPSEMPGEATETVPATEQELPQPQAETVPAVLPPAAPAASSPATAPAVLPAAHSLPLTPALGPDAQAVPTEPPSSAPAVPPAPLSPVVVPAAAIPVFSAPPQPSAPALPLPVTSSPPPAPVPPSPTGFAAQGPAAAPVSPVSPGLPAPASPVLAALPAAGQAAPPAASPSLVSPGCLPAALMPPVKVSAPPSPTGAAASAPHPAPPKSPGAAPAALPQAPPQAAAPAGTTAPPQSPPAMPVHPAAPLPPPAAPLGSPLAATISPPIFLSAPMALAPLLPGGTVPCSAAAPVRGSMSGTPTCPLAPAASGTMTCPVGPALAAPGSPAVARTPPGSPVPVTAPVLPSPPPAAALSSSGPPAAPAPAKAAPATPVSLPAAVTPASPLPVTPAMAAPATPPAAKGAPQSPVTTPSAPAAVVPAAVPAPAALSSTKAAPQSPVAATPAPIAAPSATKAAPQSPVAAPSSPAAVIPAGPPSPAAPSATKAAPQSPVVATPAPTAAPAATKAAPQSPVAAPSAPAAVVPAAPQSPGTAPSVPAAAVPAAPQAAAAPAANKVAPQSPVTAAPAPAAPPAAAKAAPGSPAAAPSAPASPPPVTPTLAAPSAPPAGKKSPKSSAAATSSPSAAAAPAGPAAPVAPTAAKKPPKGSAAAPSAAPAQAAPTVAKKPPKSPTAAQSAPSAPATAPPAQAAPPAAKKSPKSPTAAPSAPPATPAAAAKAPPKSPTAAPSSPPAAPAPSAAAKASPKSPTAAPSSPPAAPAPSAAAKASPKSPTAAPSAAPAAPAPSAAAKAPPKSPTAAPSAPPAAPAPAAAAKASPKSPTAALAAPSAPSAPPAAKAAPASPAAPGTLPAVPGAAASAPGTPGALPKPAADRGTPTPQKAEATPPASAVPNAAPAKKQPPTTKGSKQAPRPSPAKPAGKGPVPASTAVDDDDDLPPLIPPEVPAAEPPLQPILVDLSPRAAVAPAEAPAPKQPVVKNDKGSGTESDSDESVPELEEHDSTQATTQQAQLAAAAEIDEEPVSKAKQSRSEKKARKAMSKLGLRQVTGVTRVTIRKSKNILFVITKPDVYKSPASDTYIVFGEAKIEDLSQQAQLAAAEKFKVQGEAVSNIQENTQTPTVQEESEEEEVSPSPDGPVGLPHPLLPLMGGQAGCVCRHAALHLPQWQKGADPWGLQGANCAELQSELDAASLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SZJ6</accession>
    <name>A0A8C2SZJ6_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ascorbate ferrireductase (transmembrane)</fullName>
            <ecNumber evidence="11">7.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">CYB561D2</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="7.2.1.3" evidence="11"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2SZJ6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005009760.1">
        <property type="protein sequence ID" value="ENSCJPP00005006161.1"/>
        <property type="gene ID" value="ENSCJPG00005005773.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00440000038072"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031982">
        <property type="term" value="C:vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140571">
        <property type="term" value="F:transmembrane ascorbate ferrireductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140575">
        <property type="term" value="F:transmembrane monodehydroascorbate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140576">
        <property type="term" value="P:ascorbate homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd08761">
        <property type="entry name" value="Cyt_b561_CYB561D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045150">
        <property type="entry name" value="CYB561D1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15422">
        <property type="entry name" value="OS05G0565100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15422:SF21">
        <property type="entry name" value="TRANSMEMBRANE REDUCTASE CYB561D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03188">
        <property type="entry name" value="Cytochrom_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="13">
        <location>
            <begin position="18"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="229" mass="24196" checksum="5D95074D4E2027FC" modified="2022-01-19" version="1">PPRPGANMALPAEAESRLFRSLRAAAGAAAHAAALGLPAGVAVLARPGSSLFSWHPLLMALAVSLLMTEALLVFSPEASPLRALSRKAKARAHWALQVLAVLCAALGLGLVAYNKHVHGTGHLRTWHGRVGLLTALYFAAQSLGGLLLLYPKLAGGWTPGKLRLYHATAGLVGYLLGCASLMLGMCSLWFTTAARGAAWYLAVLCPVLTSLVVMNQVSNAYLYRKRSQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T082</accession>
    <name>A0A8C2T082_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">TRMT6</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Substrate-binding subunit of tRNA (adenine-N1-)-methyltransferase, which catalyzes the formation of N1-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TRM6/GCD10 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T082"/>
    <dbReference type="SMR" id="A0A8C2T082"/>
    <dbReference type="Ensembl" id="ENSCJPT00005010175.1">
        <property type="protein sequence ID" value="ENSCJPP00005006449.1"/>
        <property type="gene ID" value="ENSCJPG00005005974.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000008327"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017423">
        <property type="entry name" value="TRM6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12945">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12945:SF0">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT TRM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04189">
        <property type="entry name" value="Gcd10p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038170">
        <property type="entry name" value="tRNA_m1A_mtfrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="69"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="286"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="313"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR038170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="489" mass="55142" checksum="4A0B9D25F94C45AA" modified="2022-01-19" version="1">CMDRNKYPMPITCPRICEGDCAVLKRGDVFKAVPVLRRRKIIFEKQWFYLDKAIGHAYGTTFEVTSDGNLQPKRKVEEAPTETKEAGTDNRNIVDDGKSQKLTHDDIKALKDKGIKGQEIVQQLIENSTTFRDKTEFAQDKYIKKKRKKYEALITIVKPSTRILSTMYYAREPGKISHLRYDTLAQMLTLGNVRAGNKMVVMETCAGLVLGAVMERMGGYGTIIQMYPGGGPVRAATSCFGFPKHFFNNLHEFPLSKVDSLLCGTLSVETLPSEPEDTTLTEEEMNGLADEKQTSVQGTEEESSAETAMEINQTEEQETMDVNAEDAECKESKERENKENVREKQRKQWERRKKLTETAALLRERNADGLLVASKFHPTPLLLSLLEFVAPSRPFVVYCQYKEPLLECYTKLRERGGVVNLKLSETWLRSYQVLPDRSHPKLTMSGGGGYLLSGITVVLDKGKSDSSNSEALKMEEPSAKRCKVQDLCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T158</accession>
    <name>A0A8C2T158_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Tight junction protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">TJP3</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Tight junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MAGUK family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015741892.1">
        <property type="nucleotide sequence ID" value="XM_015886406.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T158"/>
    <dbReference type="Ensembl" id="ENSCJPT00005010382.1">
        <property type="protein sequence ID" value="ENSCJPP00005006608.1"/>
        <property type="gene ID" value="ENSCJPG00005006163.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107325496"/>
    <dbReference type="KEGG" id="cjo:107325496"/>
    <dbReference type="CTD" id="27134"/>
    <dbReference type="GeneTree" id="ENSGT00940000160036"/>
    <dbReference type="OrthoDB" id="418634at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045216">
        <property type="term" value="P:cell-cell junction organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090557">
        <property type="term" value="P:establishment of endothelial intestinal barrier"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905605">
        <property type="term" value="P:positive regulation of blood-brain barrier permeability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0150105">
        <property type="term" value="P:protein localization to cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06727">
        <property type="entry name" value="PDZ1_ZO1-like"/>
        <property type="match status" value="1"/>
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    <dbReference type="CDD" id="cd06728">
        <property type="entry name" value="PDZ2_ZO1-like_ds"/>
        <property type="match status" value="1"/>
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    <dbReference type="CDD" id="cd06729">
        <property type="entry name" value="PDZ3_ZO1-like_domain"/>
        <property type="match status" value="1"/>
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    <dbReference type="CDD" id="cd12028">
        <property type="entry name" value="SH3_ZO-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000013">
        <property type="entry name" value="Putative tight junction protein ZO-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000110">
        <property type="entry name" value="tight junction protein ZO-1 isoform X1"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
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    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
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    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
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    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005417">
        <property type="entry name" value="ZO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13865">
        <property type="entry name" value="TIGHT JUNCTION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13865:SF11">
        <property type="entry name" value="TIGHT JUNCTION PROTEIN ZO-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01597">
        <property type="entry name" value="ZONOCCLUDNS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0965">Cell junction</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="4" id="KW-0796">Tight junction</keyword>
    <feature type="domain" description="PDZ" evidence="15">
        <location>
            <begin position="178"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="15">
        <location>
            <begin position="403"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="15">
        <location>
            <begin position="601"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="13">
        <location>
            <begin position="684"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate kinase-like" evidence="14">
        <location>
            <begin position="859"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="78"/>
            <end position="111"/>
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    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="267"/>
            <end position="380"/>
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        <location>
            <begin position="492"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="995"/>
            <end position="1095"/>
        </location>
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    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="270"/>
            <end position="281"/>
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        <location>
            <begin position="321"/>
            <end position="330"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="331"/>
            <end position="343"/>
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        <location>
            <begin position="344"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1030"/>
            <end position="1057"/>
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    </feature>
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        <location>
            <begin position="1060"/>
            <end position="1079"/>
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            <dbReference type="ARBA" id="ARBA00004413"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004435"/>
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            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
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    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50106"/>
        </source>
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        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006608.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1095" mass="121272" checksum="1DEAB986B0FD11BF" modified="2022-01-19" version="1">MPRPTPALMMPPCPRGAASLRGREPGGAARSCPVLRDERRHRDTSSAVMSPSPGWPLLRRIRRFRRFRRSWAPRGAVTRSIVPPRPRGNRRAAGAGSRRVEPGAAAGIAPGGTRNELGAVVRRRVAHKGLHRAAPSSVTAATSPGAQLLPGQIQPRGTSHNHNAVAAMEEMLIWEQHTVTLSKDPHRGFGFAVSGGRDRPNKVTGDTAVIVSDVVSRGPAFGQLQRKDQIVMVNGLSMENVSSSFAIQTLKTCGKIANITLKRQKKIHLPMSKSSPASPAATRRYDSDEDYDPRGVDPALRSTSQHRSRDDLDQDYDGDSSSERSSGHHRDDRRHHKSSRSRRRSQDSSHWRHSPDSGSEHRGYSRHRSTNSLGHEGDTNGLELVSGFKRLPRRDVPTKPITSVLVKRKEDEEYGLKLGSQLFIKHIVESGLAARRSSLQEGDLILKINGVASEDMSLADTQRLIERTEGILTLHVLRDHRQFLINIPNMEDYQSDSSRMDDISDIDSDLSNPPSPKTSPRLPAAARVNSPGERRRSSRNAATDTNMDGALSHDTLEAMEQDGHHSPRSRTTARAAPNDGPPPGRYSPDSRVVQFVKARSVGLRLAGGNDVGIFVSGVQEGSPADSQGIEEGDQILQVNGTSFQNLTREEAVQFLMKLPPGEDVTLRIQSKQDIYRKMISSNVGDSFYIRTHFDYEKDTPSGLSFVRGDVFHVLDTMYRGKLGSWLAVRMGRDLQEQEKGIIPNQSRAEQFASLESVLKATPGANPSGARAEFWKLRGLRGAKKTLRKSREDLSALTKQGHYPPYERVVLKEASFKRPVVILGPITDIAMQKLSTEQPELFEIAPSVPRDGASSKVIKLDSVRQIAERDKHALLDITPSAVERLNYVQYYPVVVFCEPESRQGIKAMRQWLAPDSRKSSRRLYAQASKMKKYCSHLFTATISLSGSGNSWYEEIKGIVRTQQSQPIWTAVEHVDAALGDSLDLLNPPSRAASGYLTCDSQANSDYDDTDGEGGAYTDGEAEDTYNHPALSRSSEPAQTYPSHSVSQQVTEQQPQGQWAQEHLRDYEHEAVRRRFTRARDDSDEDEGYEWGPATDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T1P0</accession>
    <name>A0A8C2T1P0_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ETS variant transcription factor 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ETV5</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ETS family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015726780.1">
        <property type="nucleotide sequence ID" value="XM_015871294.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015726781.1">
        <property type="nucleotide sequence ID" value="XM_015871295.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T1P0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005009250.1">
        <property type="protein sequence ID" value="ENSCJPP00005005754.1"/>
        <property type="gene ID" value="ENSCJPG00005005451.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005009254.1">
        <property type="protein sequence ID" value="ENSCJPP00005005757.1"/>
        <property type="gene ID" value="ENSCJPG00005005451.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107317992"/>
    <dbReference type="KEGG" id="cjo:107317992"/>
    <dbReference type="CTD" id="2119"/>
    <dbReference type="GeneTree" id="ENSGT00940000160680"/>
    <dbReference type="OrthoDB" id="10067219at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000121">
        <property type="entry name" value="ETS translocation variant 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000418">
        <property type="entry name" value="Ets_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046328">
        <property type="entry name" value="ETS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006715">
        <property type="entry name" value="ETS_PEA3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849:SF160">
        <property type="entry name" value="ETS TRANSLOCATION VARIANT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00178">
        <property type="entry name" value="Ets"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04621">
        <property type="entry name" value="ETS_PEA3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00454">
        <property type="entry name" value="ETSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00413">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00345">
        <property type="entry name" value="ETS_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00346">
        <property type="entry name" value="ETS_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50061">
        <property type="entry name" value="ETS_DOMAIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETS" evidence="8">
        <location>
            <begin position="365"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="132"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="157"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005005757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="507" mass="57014" checksum="424B1A47F5146B24" modified="2022-01-19" version="1">MDGFYDQQVPFMGPGKSCAEEGRGRLGSERKRKFLETDLAHDSEELFQDLSQLQEAWLAEAQVPDDEQFVPDFQSDNLVLHAPPPAKIKRELHSPSSELSACSHEQALCASYGDKCLYNCCAYDRKPPTGFKPLTPPATPVSPVQPGSSLPPPPAPGVQAAAHGGPAAPLRSTAPAPHLLQEQRQQTFAVPRPPHPPMHMPKMMSENQYPTEHRFQRQMSEPCHPFPPQPGVPGDSRPVYHRQLSEPVGPAAPHPAQGFKQEYHDPLYEHAGPSLPGPPGHGFQSPMGIKQEPRDYCIDSEVPNCQSSYMRGGLFPGSHDGFSYEKDTRLYFDDTCVVPERLEGKVKQEPTLYREGPPYQRRGSLQLWQFLVTLLDDPANAHFIAWTGRGMEFKLIEPEEVARRWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPDALFSMAYPDNQRPFLKAEPDCHVSEEDTLPLTHFEDSPAYLLEVEHCGSLPYAEGFAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T2B6</accession>
    <name>A0A8C2T2B6_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">PTPN7</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="3.1.3.48" evidence="1"/>
    <dbReference type="RefSeq" id="XP_015740298.1">
        <property type="nucleotide sequence ID" value="XM_015884812.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015740299.1">
        <property type="nucleotide sequence ID" value="XM_015884813.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015740300.1">
        <property type="nucleotide sequence ID" value="XM_015884814.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032305194.1">
        <property type="nucleotide sequence ID" value="XM_032449303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T2B6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005011495.1">
        <property type="protein sequence ID" value="ENSCJPP00005007406.1"/>
        <property type="gene ID" value="ENSCJPG00005006834.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107324634"/>
    <dbReference type="KEGG" id="cjo:107324634"/>
    <dbReference type="CTD" id="5778"/>
    <dbReference type="GeneTree" id="ENSGT00940000160979"/>
    <dbReference type="OrthoDB" id="9993594at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030054">
        <property type="term" value="C:cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14612">
        <property type="entry name" value="PTPc-N7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000020">
        <property type="entry name" value="Tyrosine-protein phosphatase non-receptor type 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008356">
        <property type="entry name" value="Tyr_Pase_KIM-con"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46198">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46198:SF3">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01778">
        <property type="entry name" value="KIMPTPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="7">
        <location>
            <begin position="100"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="8">
        <location>
            <begin position="271"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="5">
        <location>
            <position position="294"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="294"/>
            <end position="300"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR608356-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR608356-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005007406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="363" mass="40778" checksum="CB7EC5A1244AE55D" modified="2022-01-19" version="1">MVQACTVCHRAHNSSLTARVATKTMDKADKPSPSVKKHVRLQERRGSNVSLVLDMSSLGSVEPIQPVCTPRDITLQFLRTSSHVLRTEELQQRAQSLAQLQEEFSKIPPNFISPEELEIPGHASKDRYKTILPNPESRVCLRRAGSQEENGYINANYITGYAGRPREYIATQGPMLNTVSDFWRMVWQEQSPIIVMITELQERKEKCVHYWPEKEGTYGPFTIRVQGINECAEYVVRNLSIQLEGECRHIKHILFPSWPDQQTPESAKPLLHLVSKVEETLQAAASLGPIVVHCSAGIGRTGCFIATRIGCQQLKDKGDVDILGIVCRLRIDRGGMIQTSEQYQFLHHTLALYASQLPDAGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T3G3</accession>
    <name>A0A8C2T3G3_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T3G3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005010154.1">
        <property type="protein sequence ID" value="ENSCJPP00005006438.1"/>
        <property type="gene ID" value="ENSCJPG00005006024.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182865"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome Z"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051188">
        <property type="entry name" value="PHD-type_Zinc_Finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059102">
        <property type="entry name" value="PHD_PHF7/G2E3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12420">
        <property type="entry name" value="PHD FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12420:SF47">
        <property type="entry name" value="PHD FINGER PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26054">
        <property type="entry name" value="PHD_G2E3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13771">
        <property type="entry name" value="zf-HC5HC2H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="138"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="316" mass="34437" checksum="5E60E87D93005043" modified="2022-01-19" version="1">SAVCMLCRRTQVNPDICGQISVNGGLCAHQFCVVSSLKAQSSCQGCSHPFWPHEITLFSLLQFFADGLLKWRSRHCFVCGERGATISCAETGCERSFHLPCAEDGECVTQYFGQYRSFCSEHRPQQAQEAAPSPNTPCIICVEPVGDSTSYHTMMCPVCKEAWFHRGCIWKYAMHAATMCFYCPVCRSKGPFRSNMTALGIQIPVRLNCAGCSLPWFTSSSQPQPLSFCRLWELYLCTSCGAQGMHRYCSFWGPMITSWECSSCAGQETGKRQRAMCRGTGARHGLAVGVQGGLATVSLPHGAGSLSCPGAACSSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T4D9</accession>
    <name>A0A8C2T4D9_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T4D9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005010677.1">
        <property type="protein sequence ID" value="ENSCJPP00005006858.1"/>
        <property type="gene ID" value="ENSCJPG00005006330.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000287833"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF3">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="317" mass="33505" checksum="0BE8328455A259F0" modified="2022-01-19" version="1">MGDMGAINGAKRTRVINRTINRATYRAMAINRAINRAINRAVNRTINRAINGAINGTINRATYRATNGAMHRTINRAINRATNRVIYKNINRATYRAINRAINGAMYRTINGATYRATYRAINGAINRAINIPSIGPSIGPPIGPCIGPCIGPSMGPCIGPYIGPCIGPCIGPYIGPYIWPCIGPYIGPYIGPCIGPCIGPYIGPCIGPYIGPCIEQCIGQCIGPPIGPCIGPYIGPYIWPYIWPSIGPCIGPSIGPPIEPCIGPYIGPYIWPCIGPSIGPCIGPYIWPCIGPSIGPRIGPYIGPSIGLCIGPSIGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T4K9</accession>
    <name>A0A8C2T4K9_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">IRF tryptophan pentad repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T4K9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005009808.1">
        <property type="protein sequence ID" value="ENSCJPP00005006193.1"/>
        <property type="gene ID" value="ENSCJPG00005005811.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163813"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002376">
        <property type="term" value="P:immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00103">
        <property type="entry name" value="IRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000041">
        <property type="entry name" value="Interferon regulatory factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.10:FF:000013">
        <property type="entry name" value="Interferon regulatory factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019817">
        <property type="entry name" value="Interferon_reg_fac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001346">
        <property type="entry name" value="Interferon_reg_fact_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019471">
        <property type="entry name" value="Interferon_reg_factor-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017855">
        <property type="entry name" value="SMAD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11949">
        <property type="entry name" value="INTERFERON REGULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11949:SF24">
        <property type="entry name" value="INTERFERON REGULATORY FACTOR 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00605">
        <property type="entry name" value="IRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10401">
        <property type="entry name" value="IRF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00267">
        <property type="entry name" value="INTFRNREGFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00348">
        <property type="entry name" value="IRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01243">
        <property type="entry name" value="IRF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00601">
        <property type="entry name" value="IRF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51507">
        <property type="entry name" value="IRF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="IRF tryptophan pentad repeat" evidence="8">
        <location>
            <begin position="7"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="121"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="138"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="449" mass="51382" checksum="AAC4F03B0BF8B477" modified="2022-01-19" version="1">MAEPGSPMRLKEWLIAQIDSGRYPGLRWENRERTLFRIPWKHAAKQDYRQQQDAALFRAWAVYKGKYHEGTDKAEPATWKTRLRCALNKSPDFEEVTDRSQLDISEPYKVYQIVCDGTRDAEKDEKESRMQPTTSKDPQGHVAEESHRGTAGTCHTLPLLSAHPAERGYHVRGIFYGWSPTHSHLLPRAPSFLPAEDVNHSDCWLHIRLYYCDVLVKELTTRTAEGCRIATRTEGPYGPSRMELIEFPSPRALGSSGWTVAVTEVLERLLPHLERGVLLWVAPEGVFMKRQCQGRVYWNGPLAPHRDWPNKLEREKTYKLLDTQQFLEELRRYLSHGQPAPRYQIHLCFGEEYPTSTGHHLQKLIMAHVSTHRAADPCAHQWGDGDPQCQARTPSSQQLRALQVEPVFARELFHHAQRLGPALLRGCPQPCAPTAPGRIAHVLQQLCQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T4S2</accession>
    <name>A0A8C2T4S2_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GRAM domain containing 2A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">GRAMD2A</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T4S2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005012382.1">
        <property type="protein sequence ID" value="ENSCJPP00005008108.1"/>
        <property type="gene ID" value="ENSCJPG00005007314.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159572"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044232">
        <property type="term" value="C:organelle membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061817">
        <property type="term" value="P:endoplasmic reticulum-plasma membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001256">
        <property type="term" value="P:regulation of store-operated calcium entry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd13220">
        <property type="entry name" value="PH-GRAM_GRAMDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042624">
        <property type="entry name" value="RAMD2A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46973">
        <property type="entry name" value="GRAM DOMAIN-CONTAINING PROTEIN 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46973:SF1">
        <property type="entry name" value="GRAM DOMAIN-CONTAINING PROTEIN 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00568">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="GRAM" evidence="2">
        <location>
            <begin position="87"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005008108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="338" mass="37567" checksum="CE62F1557012B25D" modified="2022-01-19" version="1">MESEPPSFLWQLFRQLVAIAGNVCGTVLSRVELGLVSSPQCSYLLLLLTVLLSSVADCQQVQLPVPQAVQGHPDGGERAERWAAQRGVGQELWGCRALTPLCSTVCSCALQRDILIQGRLYISPNWLCFYANLFGKDIKVVIPVVSVQLIKKHKTARLLPNGLAITTTASRKYIFVSLISRDSVYDVLRRVCTHLQVSSKKSLSLKELTEEPDAVSLEVIVPEGKWRKVSPASLSLSLPDADYQCIHRTSVSSLSAKESFTSEEPLASESAINTEEELEAEQGCVAELRPSDYQLLKIFIVLICLLVVSSSYLAFRIFRLEQQLCSLNRDYLSRGHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T4V0</accession>
    <name>A0A8C2T4V0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F237A protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116652594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_032297498.1">
        <property type="nucleotide sequence ID" value="XM_032441607.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032297499.1">
        <property type="nucleotide sequence ID" value="XM_032441608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T4V0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005012957.1">
        <property type="protein sequence ID" value="ENSCJPP00005008559.1"/>
        <property type="gene ID" value="ENSCJPG00005007639.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116652594"/>
    <dbReference type="KEGG" id="cjo:116652594"/>
    <dbReference type="GeneTree" id="ENSGT00390000015769"/>
    <dbReference type="OrthoDB" id="9931800at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040439">
        <property type="entry name" value="FAM237A/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36690">
        <property type="entry name" value="PROTEIN FAM237A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36690:SF2">
        <property type="entry name" value="PROTEIN FAM237A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034617502" description="F237A protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005008559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="173" mass="19926" checksum="F01BDB4C715286E0" modified="2022-01-19" version="1">MRLTYSLLVMGMFCLTPSLCHSQIDPLALGRADPQCWESSSAVLLEMRKPHISDSVSGFWDFMIFLKSSENLKHGALFWDLAQLFWDIYVDCVLSRTHGLGRRQLAEAQQRITTLASQFTGRNQGMFTHIQRSPVLRKRDLFEDLIKKHKHKSRSTLLGRIIGELGEKKKQHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T555</accession>
    <name>A0A8C2T555_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">TNFAIP3-interacting protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">A20-binding inhibitor of NF-kappa-B activation 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Nef-associated factor 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Virion-associated nuclear shuttling protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">TNIP1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015731321.1">
        <property type="nucleotide sequence ID" value="XM_015875835.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015731322.1">
        <property type="nucleotide sequence ID" value="XM_015875836.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T555"/>
    <dbReference type="Ensembl" id="ENSCJPT00005011733.1">
        <property type="protein sequence ID" value="ENSCJPP00005007600.1"/>
        <property type="gene ID" value="ENSCJPG00005006963.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107320194"/>
    <dbReference type="KEGG" id="cjo:107320194"/>
    <dbReference type="CTD" id="10318"/>
    <dbReference type="GeneTree" id="ENSGT00510000046908"/>
    <dbReference type="OrthoDB" id="10059994at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051019">
        <property type="term" value="F:mitogen-activated protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071222">
        <property type="term" value="P:cellular response to lipopolysaccharide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009101">
        <property type="term" value="P:glycoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007159">
        <property type="term" value="P:leukocyte cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043124">
        <property type="term" value="P:negative regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070373">
        <property type="term" value="P:negative regulation of ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903003">
        <property type="term" value="P:positive regulation of protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.990:FF:000001">
        <property type="entry name" value="TNFAIP3 interacting protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.990">
        <property type="entry name" value="Nemo cc2-lz domain - 1d5 darpin complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31882:SF3">
        <property type="entry name" value="TNFAIP3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31882">
        <property type="entry name" value="TNFAIP3-INTERACTING PROTEIN COILED COIL FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0395">Inflammatory response</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="483"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="582"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="27"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="205"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="276"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="487"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00073021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00075165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00079468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00081786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005007600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="614" mass="70200" checksum="9B83D54B3D2F3406" modified="2022-01-19" version="1">MAAMEGRGPYHIYDPGGGTEENGSTAYERLMEENARLKERMQGIKSIGELLEESQVEASKLRQKAEDLVKDNKMLIASSALEELVETGAACPEHSSALATPGSAQPDTGTRKSPSGSSSEFEVVAAEAQGCPQDSGRAELEPLPHEDANLLPQLQQLENTLSGCAREASKDQVFVRMGYMASELKRLASKVHKNEQRTSFLQTLCETLHTENKELRTKLERDLEQRNQALEKLRCENQELRRMVTLSNQESAKREAAEQQQQSGVVVEKAAGRGELEAKEKKVKILEHQRRELLEVNKQWDQHFRAMKQKYEQKMTDLHQELAEARRALTELESEREQKQRDFDRKLLLAKSRIETEEAEKDRLGMEVRDLQQRMRFLQEQLAPVTRQREYQEKEIQRLNKALEEALNVQASPPPIFAGTLEPAGKVPPQELLTQNELLKQQVKIFEEDFQRERSDRERMNEEKEELKQQLEKLQKQLAVSNNQLRASKDDCQREKEEKEKLKKMLKQHKQASGERLHPDPVPGPLGPTCPMYQYQYSPPVPHPVYHGYDEWQQIRYPPALQGEQAPGQNFHHYPPPEYPWRPPCAMARSQSATAVPGVKPVPKDLDQAGPVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T5L9</accession>
    <name>A0A8C2T5L9_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Leucine rich repeat transmembrane neuronal 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LRRTM1</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Postsynaptic cell membrane</location>
            <topology evidence="10">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the LRRTM family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015718139.1">
        <property type="nucleotide sequence ID" value="XM_015862653.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T5L9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005011416.1">
        <property type="protein sequence ID" value="ENSCJPP00005007362.1"/>
        <property type="gene ID" value="ENSCJPG00005006792.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107313931"/>
    <dbReference type="KEGG" id="cjo:107313931"/>
    <dbReference type="CTD" id="347730"/>
    <dbReference type="GeneTree" id="ENSGT00940000161705"/>
    <dbReference type="OrthoDB" id="5984255at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098982">
        <property type="term" value="C:GABA-ergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030426">
        <property type="term" value="C:growth cone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099634">
        <property type="term" value="C:postsynaptic specialization membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000005">
        <property type="entry name" value="leucine-rich repeat transmembrane neuronal protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050467">
        <property type="entry name" value="LRFN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000372">
        <property type="entry name" value="LRRNT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45842:SF12">
        <property type="entry name" value="KEKKON 5, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45842">
        <property type="entry name" value="SYNAPTIC ADHESION-LIKE MOLECULE SALM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00013">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="453"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="LRRNT" evidence="13">
        <location>
            <begin position="64"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00035006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005007362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="547" mass="62172" checksum="E73B669CE8CC1989" modified="2022-01-19" version="1">MASVFLTENLKRFNGHSRAYLEIFLLMDFLLIGLCLNWLLRKPPGLILCMLGIFSKMLPAVNSGCPQLCRCEGRLLYCESLNLTEMPRNLSGMMGLSLRYNSLSELHDGQFTGLMQLTWLYLDHNHICSVEGNAFQKLRRVKELTLSSNKITQLPNNTFRPMPNLRSVDLSYNNLQSLEPDLFHGLRKLTTLHMRSNAIKFVPVRIFQDCRSLKFLDIGYNQLKSLARNSFAGLFKLTELHLEHNDLVKVNLAHFPRLISLHSLCLRRNKVTIVVNTLDWIWQLEKLDLSGNEIEYIEPHVFESVPHLKSLQLDSNRLTYIDSRILDSWKSLTSISLSANTWDCGRNVCALASWLSSFKGRYDSNLLCATPEYAQGEDVLDAVYAFHLCEDTVDPTSINTLSPVTNNSDQMFGYGSAAATAYVPEADEEPTTYAITVTLPGEGAENAVQIHKVVTGTMALIFSFLIVVLVLYVSWKCFPASIRQLRQCFVTQRRKQKQKQTMHQMAAMSAQEYYVDYKPNHIEGALVIINEYGSCSCHQQPARECEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T630</accession>
    <name>A0A8C2T630_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Solute carrier family 2, facilitated glucose transporter member 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">SLC2A1</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Facilitative glucose transporter, which is responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses. Most important energy carrier of the brain: present at the blood-brain barrier and assures the energy-independent, facilitative transport of glucose into the brain. In association with BSG and NXNL1, promotes retinal cone survival by increasing glucose uptake into photoreceptors. Required for mesendoderm differentiation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glucose(out) = D-glucose(in)</text>
            <dbReference type="Rhea" id="RHEA:60376"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Photoreceptor inner segment</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T630"/>
    <dbReference type="Ensembl" id="ENSCJPT00005011957.1">
        <property type="protein sequence ID" value="ENSCJPP00005007798.1"/>
        <property type="gene ID" value="ENSCJPG00005007089.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156792"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990350">
        <property type="term" value="C:glucose transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001917">
        <property type="term" value="C:photoreceptor inner segment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055056">
        <property type="term" value="F:D-glucose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007417">
        <property type="term" value="P:central nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046323">
        <property type="term" value="P:D-glucose import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098708">
        <property type="term" value="P:D-glucose import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070837">
        <property type="term" value="P:dehydroascorbic acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015911">
        <property type="term" value="P:long-chain fatty acid import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045494">
        <property type="term" value="P:photoreceptor cell maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065003">
        <property type="term" value="P:protein-containing complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032868">
        <property type="term" value="P:response to insulin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0150104">
        <property type="term" value="P:transport across blood-brain barrier"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd17431">
        <property type="entry name" value="MFS_GLUT_Class1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000040">
        <property type="entry name" value="Solute carrier family 2, facilitated glucose transporter member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002439">
        <property type="entry name" value="Glu_transpt_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045263">
        <property type="entry name" value="GLUT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503:SF51">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2, FACILITATED GLUCOSE TRANSPORTER MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01190">
        <property type="entry name" value="GLUCTRSPORT1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="9 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6 14" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034681619" description="Solute carrier family 2, facilitated glucose transporter member 1" evidence="17">
        <location>
            <begin position="16"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="352"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="380"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="419"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="449"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="18">
        <location>
            <begin position="8"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="485"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005007798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="508" mass="55326" checksum="571EFEF7838C4B6A" modified="2022-01-19" version="1">MTARLMLAVGGAVLGSLQFGYNTGVINAPQKVRAEHRENKHTSVPPRASALSLAEIVHPASNNSLGLGDCWPISPATLTTLWSLSVAIFSVGGMIGSFSVGLFVNRFGRRNSMLMSNILAFLAAVLMGFSKMALSFEMLILGRFIIGLYSGLTTGFVPMYVGEVSPTALRGALGTFHQLGIVLGILIAQVFGLDLIMGNDSLWPLLLGFIFVPALLQCIILPFAPESPRFLLINRNEENKAKSVLKKLRGTTDVSSDLQEMKEESRQMMREKKVTIMELFRSPMYRQPILIAIVLQLSQQLSGINAVFYYSTSIFEKSGVEQPVYATIGSGVVNTAFTVVSLFVVERAGRRTLHLVGLAGMAGCAVLMTIALTLLDQMAWMSYLSIVAIFGFVAFFEIGPGPIPWFIVAELFSQGPRPAAFAVAGLSNWTSNFIVGMGFQYIAQLCGSYVFIIFMVLLVLFFIFTYFKVPETKGRTFDEIASGFRQGGASQSDKTPDEFHSLGADSQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T6P7</accession>
    <name>A0A8C2T6P7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Guided entry of tail-anchored proteins factor 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Tail-anchored protein insertion receptor WRB</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Tryptophan-rich basic protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">GET1</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WRB/GET1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015738192.2">
        <property type="nucleotide sequence ID" value="XM_015882706.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T6P7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005013911.1">
        <property type="protein sequence ID" value="ENSCJPP00005009307.1"/>
        <property type="gene ID" value="ENSCJPG00005008185.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107323518"/>
    <dbReference type="KEGG" id="cjo:107323518"/>
    <dbReference type="CTD" id="7485"/>
    <dbReference type="GeneTree" id="ENSGT00390000008610"/>
    <dbReference type="OrthoDB" id="69461at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043529">
        <property type="term" value="C:GET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071816">
        <property type="term" value="P:tail-anchored membrane protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.660:FF:000004">
        <property type="entry name" value="tail-anchored protein insertion receptor WRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028945">
        <property type="entry name" value="Get1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42650:SF1">
        <property type="entry name" value="GUIDED ENTRY OF TAIL-ANCHORED PROTEINS FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42650">
        <property type="entry name" value="TAIL-ANCHORED PROTEIN INSERTION RECEPTOR WRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04420">
        <property type="entry name" value="CHD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="363"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="26"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="113"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="258"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005009307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="393" mass="43194" checksum="38EE5ED790D9544C" modified="2022-01-19" version="1">MRGAQRRAQAAHDAGLCRPLLSAAAFGSRGSAGRPPRAAEPSRRGRSRQRCAAQHRPFSALCPPPSSAECRQPLPSSPFVFSLLVPPPTLSVPRLGRSPLSSPFSLAWRSARRRPARLAAATRRVSPRQALRPRYAAQGNSPPPSQQRQRRRNRIQPDWRPGGGAGGDGGTRQRAGTEPGLPSRRGGASHLTTARMEVRAAGWPDGVTWRYLCPIPLRAPAPSMADSGAWLLVLSAVFLCNALKILLPSCSSIISKLLQKDAEQESQMRAEIQNMKQELSTISMMDEFARYARLERKINKMTDKLKTHVKARTAQLAKIKWVINIVFYILQAALMISLIWKYYSEPVTILPSKWLAPLERLVAFPTGLAGGVGITCWLVVCNKVVAIMLHPFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T6X2</accession>
    <name>A0A8C2T6X2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcription initiation factor IIB</fullName>
            <ecNumber evidence="4">2.3.1.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">General transcription factor TFIIB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">GTF2B</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="19">General transcription factor that plays a role in transcription initiation by RNA polymerase II (Pol II). Involved in the pre-initiation complex (PIC) formation and Pol II recruitment at promoter DNA. Together with the TATA box-bound TBP forms the core initiation complex and provides a bridge between TBP and the Pol II-TFIIF complex. Released from the PIC early following the onset of transcription during the initiation and elongation transition and reassociates with TBP during the next transcription cycle. Associates with chromatin to core promoter-specific regions. Binds to two distinct DNA core promoter consensus sequence elements in a TBP-independent manner; these IIB-recognition elements (BREs) are localized immediately upstream (BREu), 5'-[GC][GC][GA]CGCC-3', and downstream (BREd), 5'-[GA]T[TGA][TG][GT][TG][TG]-3', of the TATA box element. Modulates transcription start site selection. Also exhibits autoacetyltransferase activity that contributes to the activated transcription.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TFIIB family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="4"/>
    <dbReference type="RefSeq" id="XP_015725571.1">
        <property type="nucleotide sequence ID" value="XM_015870085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T6X2"/>
    <dbReference type="SMR" id="A0A8C2T6X2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005014036.1">
        <property type="protein sequence ID" value="ENSCJPP00005009391.1"/>
        <property type="gene ID" value="ENSCJPG00005008246.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107317421"/>
    <dbReference type="KEGG" id="cjo:107317421"/>
    <dbReference type="CTD" id="2959"/>
    <dbReference type="GeneTree" id="ENSGT00390000006671"/>
    <dbReference type="OrthoDB" id="25790at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042585">
        <property type="term" value="C:germinal vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046966">
        <property type="term" value="F:nuclear thyroid hormone receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990841">
        <property type="term" value="F:promoter-specific chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061733">
        <property type="term" value="F:protein-lysine-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000979">
        <property type="term" value="F:RNA polymerase II core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051177">
        <property type="term" value="P:meiotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990114">
        <property type="term" value="P:RNA polymerase II core complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001174">
        <property type="term" value="P:transcriptional start site selection at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019083">
        <property type="term" value="P:viral transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd20551">
        <property type="entry name" value="CYCLIN_TFIIB_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20552">
        <property type="entry name" value="CYCLIN_TFIIB_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000008">
        <property type="entry name" value="Transcription initiation factor IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000019">
        <property type="entry name" value="transcription initiation factor IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000007">
        <property type="entry name" value="Transcription initiation factor IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023486">
        <property type="entry name" value="TFIIB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618:SF77">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="Zn_Ribbon_TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00782">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="14" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 20" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIB-type" evidence="21">
        <location>
            <begin position="11"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00056112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005009391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="316" mass="34806" checksum="B158A3EB08D7BD61" modified="2022-01-19" version="1">MASTSRLDALPRVTCPNHPDSILVEDYRAGDMICSECGLVVGDRVIDVGSEWRTFSNDKATKDPSRVGDTQNPLLSDGDLSTMIGKGTGAASFDEFGNSKYQNRRTMSSSDRAMMNAFKEITNMADRINLPRNIVDRTNNLFKQVYEQKSLKGRSNDAIASACLYIACRQEGVPRTFKEICAVSRISKKEIGRCFKLILKALETSVDLITTGDFMSRFCSNLGLPKQVQMAATHIARKAVELDLVPGRSPISVAAAAIYMASQASAEKRTQKEIGDIAGVADVTIRQSYRLIYPRAPDLFPADFKFDTPVDKLPQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T7W2</accession>
    <name>A0A8C2T7W2_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">COMM domain containing 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">COMMD4</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T7W2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005013259.1">
        <property type="protein sequence ID" value="ENSCJPP00005008788.1"/>
        <property type="gene ID" value="ENSCJPG00005007798.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000015516"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd04752">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017920">
        <property type="entry name" value="COMM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037356">
        <property type="entry name" value="COMMD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047155">
        <property type="entry name" value="COMMD4/6/7/8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16231:SF4">
        <property type="entry name" value="COMM DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16231">
        <property type="entry name" value="COMM DOMAIN-CONTAINING PROTEIN 4-8 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07258">
        <property type="entry name" value="COMM_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21672">
        <property type="entry name" value="COMM_HN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51269">
        <property type="entry name" value="COMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="COMM" evidence="1">
        <location>
            <begin position="130"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005008788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="219" mass="23697" checksum="C788C422A919EC94" modified="2022-01-19" version="1">MRFRFCGDLDCPDWVLAEISVLARISSVKLKLICAQVLRELLGDNIDYEKILKLTSDAKLESGDVKAAIAVLDFILSNAAKHNVDGESLSSELQQLGLPKEHATGLCRSYEEKQSSLQDSLRAGSLRLSRLDGVSWRVDYTLSSSELQDVGEPLVHLLLRVKHREHGEPEAVPVAVSADKFRVLLAGEGVQLGAEGGPALCLGPSEGRSVSHSPSTPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T8W5</accession>
    <name>A0A8C2T8W5_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T8W5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005014935.1">
        <property type="protein sequence ID" value="ENSCJPP00005010042.1"/>
        <property type="gene ID" value="ENSCJPG00005008785.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286942"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004946">
        <property type="term" value="F:bombesin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001556">
        <property type="entry name" value="Bombsn_rcpt-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001642">
        <property type="entry name" value="NeuroB_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF8">
        <property type="entry name" value="NEUROMEDIN-B RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00358">
        <property type="entry name" value="BOMBESINR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00639">
        <property type="entry name" value="NEUROMEDINBR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="228"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="69"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005010042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="318" mass="36655" checksum="6637B30A198444FE" modified="2022-01-19" version="1">MPSCIQLKDNAEVFWAEPSFYFFLFLWKRALCLKDFKFRVSHSSAICAMSPKLLHEYLLICNCVFIPFRYKAIVKPMDIQTSSAVLRTCAKAIAIWIISILLSVPEAVFSELAHINDTDNATFTACIPYPMTDDMHPKIHSVLIFLVYFLIPLAIISIYYYHIAKSLIRSAHNIPGENNEHSKRLMETRKRLAKIVLVFVGFFAICWFPNHVLYMYRSFNYNEIDSSIGHMVVTLVARVLSFCNSCVNPFALYLLSESFRRHFNNQLCCRKKSQRERSASYLRNSSAIQTTSLKSNTRNTVTSVTQLNGHNLKQEMSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T983</accession>
    <name>A0A8C2T983_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">BarH like homeobox 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BARHL2</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the BAR homeobox family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015725401.1">
        <property type="nucleotide sequence ID" value="XM_015869915.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T983"/>
    <dbReference type="Ensembl" id="ENSCJPT00005013960.1">
        <property type="protein sequence ID" value="ENSCJPP00005009342.1"/>
        <property type="gene ID" value="ENSCJPG00005008213.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107317349"/>
    <dbReference type="KEGG" id="cjo:107317349"/>
    <dbReference type="CTD" id="343472"/>
    <dbReference type="GeneTree" id="ENSGT00940000158611"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035881">
        <property type="term" value="P:amacrine cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001709">
        <property type="term" value="P:cell fate determination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001764">
        <property type="term" value="P:neuron migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030516">
        <property type="term" value="P:regulation of axon extension"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000097">
        <property type="entry name" value="barH-like 2 homeobox protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052145">
        <property type="entry name" value="Mediator/Homeobox_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24330:SF4">
        <property type="entry name" value="BARH-LIKE 2 HOMEOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24330">
        <property type="entry name" value="HOMEOBOX PROTEIN BARH-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 8 9" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="11">
        <location>
            <begin position="212"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="8">
        <location>
            <begin position="214"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="165"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005009342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="369" mass="39432" checksum="312FA012CA338985" modified="2022-01-19" version="1">MEGPSGSSFGIDTILAGGGSGSPGVMNGDFRPHGDGRPADFRSQATPSPCSEIDTVGTAPSSPVSVSMEHSEPRLAAAESLPPPPHRLHLGPHPPPPGLQPSPPQPQPPQLGSAGAGPRTATSSFLIKDILGDGKPLAACAPYSTSVPSPHHTPKQEGGAAPESFRPKLEQEDKAKLDKREDPQGDIKCHGTKEEGDREISSSRDSPPVRAKKPRKARTAFSDHQLNQLERSFERQKYLSVQDRMDLAAALNLTDTQVKTWYQNRRTKWKRQTAVGLELLAEAGNYSALQRMFPSPYFYHPSLLGSMDSTTAAAAAAAMYSSMYRTPPAPHPQLQRPLVPRVLIHGLGPGGQPALNPLGSPMPGTPHPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TBQ3</accession>
    <name>A0A8C2TBQ3_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Family with sequence similarity 133 member B</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM133 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TBQ3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005016542.1">
        <property type="protein sequence ID" value="ENSCJPP00005011301.1"/>
        <property type="gene ID" value="ENSCJPG00005009714.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00730000111097"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026766">
        <property type="entry name" value="Fam133"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31911:SF1">
        <property type="entry name" value="FAMILY WITH SEQUENCE SIMILARITY 133 MEMBER B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31911">
        <property type="entry name" value="PROTEIN FAM133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="19"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="77"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="90"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005011301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="132" mass="15327" checksum="595CE8667546F484" modified="2022-01-19" version="1">MGKRDNRVAYMNPIAMARARGPAQNSGPTIQDYLNRPRPTWEEVKEQLEKKKKGSRALAEFEEKMNENWKKELEKHREKLLGGNESSSKKKEKKKKEKKKSSRVSKIFSFLSLFLLWDCACLPFGFSCKEGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TBV7</accession>
    <name>A0A8C2TBV7_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zinc finger ZZ-type and EF-hand domain containing 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ZZEF1</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="Ensembl" id="ENSCJPT00005015807.1">
        <property type="protein sequence ID" value="ENSCJPP00005010718.1"/>
        <property type="gene ID" value="ENSCJPG00005008969.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155045"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08667">
        <property type="entry name" value="APC10-ZZEF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02249">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02343">
        <property type="entry name" value="ZZ_EF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004939">
        <property type="entry name" value="APC_su10/DOC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040099">
        <property type="entry name" value="ZZEF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047052">
        <property type="entry name" value="ZZEF1_APC10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041986">
        <property type="entry name" value="ZZEF1_ZZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22772">
        <property type="entry name" value="NOVEL ZZ TYPE ZINC FINGER DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22772:SF4">
        <property type="entry name" value="ZINC FINGER ZZ-TYPE AND EF-HAND DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03256">
        <property type="entry name" value="ANAPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01337">
        <property type="entry name" value="APC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51284">
        <property type="entry name" value="DOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01357">
        <property type="entry name" value="ZF_ZZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="104"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="DOC" evidence="8">
        <location>
            <begin position="219"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="6">
        <location>
            <begin position="1790"/>
            <end position="1845"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="6">
        <location>
            <begin position="1839"/>
            <end position="1894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1257"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1453"/>
            <end position="1540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1983"/>
            <end position="2020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1265"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1454"/>
            <end position="1464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1473"/>
            <end position="1483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2002"/>
            <end position="2015"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005010718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="2902" mass="327151" checksum="98803B1F27391DC3" modified="2022-01-19" version="1">MGTAVSHSSEEEEEEAAEEGMEPAQHGDPFPAAPLPPVEVLLEQARLREATARLRETALPESLVSRHHGALVRWLEERMSRGDEAVSLEQFCEVLESVSRMNAGSRGESEEAFAQFDAEGDGTVDVENMLEALKNSSGANLQGELSHVIRQLQACSLVPGFIDIFSESKERLGLHASMILRFLHRNRISSTAIPYPVLEYFNNICMMRSSVLKDSLDRLLLKEKEYPSDLNGNEESDKLKSVTKCYTHIETSSNSADIDKMTNGETTSFWQSDGSARSHWIRLKMKPDVVLRHLSIAVAANDQSYMPQQVTVAVGRNASSLQEVRDVHIPSNITGYVTLLENANISQMYVQINIKRCLSDGCDTRIHGLRAIGYQRVKKVGVSVCDASAIWYWSLLTSLVTASMETNPAFVHTILQNTQRALQHMPPLSLTPSSTDFSNFLSPNVLQEVDSFLIRITSCCTTPDVELTLLAFALARGSVAKVISSLCTITDHLDTPYKASSLIASMATVRQNLLYKYGKPLRLTLQACDVKGKEDKSGPENLLVEPWTGDGFLTETGKTRASIILSTGTESSFQVTQIRIKVRRGAIGAQCGLVFAYNSASEKFHAEEHFKRFESYDKWKLKEFKQFLKSRSSSSSDELGDDDPIGWFEVEEEWDEVDVKMQQCRVAQYLMIKFLCTRQDTAERLGVQGLNVLGYLRPVREEPSRSMHCLQCRKADDETVCGTTLLLKTLHFIQQLAQDLVQQKESGLKSKSYLDFTDLDLQLFWNFYNKLQQNPREECIFAQTLLLQLLQSCFSVLTEDNKTSKPQETFQSKTPGHAKAAEDLYRHLCEVVDMEDTNFMPVKMLKQEVKNTLLSGAAIFFPDRQTRRNQLFAMMKNITEQERKQSVHLAFRSLCTHFSDQDPGGLLLLPEKGVSANFDISEVLSVMDTLLLVAARECEMMMLDVAQQESGTVLSSLFWSVQGSLLSWCYLQLKGSDSTAKDLAVEILKNYVGQFLTNIRMILQSLLSQYSGKTIVEKISNSVFAMATRQLVIFLLDFCTLDIPHCTLLQEFSTLVEPLKKLCCEPHKVTKDTVPTCDWQQEQPVVLRTWTVESPHNYENNCHEVSVFLCHGASYFEVEFDEKCETERRYDYLEFTDARGAKTRYDTKVGTEKWPKKVTFKAGPRLQFLFHSDSSNNEWGYKFTVTAFGLPDVAVSWGLDLQLLVCRLMGRLASRSMALKSLRELGSEADLPPLKVTSVLNSPLWKPVFRHQMCPEAEPGASETSRGHHDKKEVLRSSHQDDCRNFLIDFAKSDPTQDFSGQKSELFKGLVQTCRKQAPKTDAVAGSIVDRAVNSTFAALVYLTPALYEKLQKYVNSGGKVPLSDEFAQVYSLADSIRIWMLEMKQKSLMGRGNDTEEKQSTEASEVNPETLAKLCMQKSLLLLNFLPVRAKTKSSALDSLEAQDSDHVHQYVTGKNQRKSSVVETDFQAAHSSSSNGVTRSVSVEREQTTQSDTKIKQIPGPLQTEEASAFHSKPSENTALQQEDVPSPPSTPTRKSQFSRGRLRLLSFRSMEEPRAVPTLKEKYPILKNILDFIKDQSLSHESVLKVLALRKSQGQNILEVLKTIRRCLGSLGQPHCFHPSCVLFLLELLACQKDFTNYFGNLEGCGVALHKEIRESYYQLVLFLVNSVKGFSAINDRSLLPALSCVQTTLLHLLDMSWEPSDLSFFVEIQLPQLLMATSQENISIHDSVICQWSEEDEIADYKQNCEWMDECQDIMFESWYEKIAQADPEKQRKMHMFVARYCDLLNVDISCDGCDEIAPWHRYRCLQCNDMDLCKTCFLGGVKPEGHEDDHEMVNMEYACDHCQGVIIGRRMNCNVCDDFDLCYGCYSAKKYSDSHLPTHSITVYPMVTIRISDRQRLIQPYVHNYSWLLFAALTLYSADLANGEEVEGEKLDSQVLSHARVLQHQCIQLIGDCLMKAQQGKGLKNLALLCMLPEGESLPENDTVSVSPPTDGAPKSHTGDKAGKAKDEKPSTGSFMHSNVTDDCVSEDSAQKQAEKVLIPSQEQVFAECSQKRILGLLAAMLPPFKSGSTMSLINLEQILPLMFQVVISNAGHLNETYHLTLGLLGQLILRLKPAEVDAAVAKVLSTKHSLFAPGDPSTVPEGWKTTHLLFSLGAVCLDSRVGLDWASSMADILRSLNSSAQWHSVIAAFTDHCIKQLPFQLKHTNIFTLLVLVGFPEVLCMGTRSVYMDNANEPHNVIILKHFTEKNRAVVVDIKTRKRKTVKDYQLIQKCEQEGSDSQAQLRQYLQHFVLICTHLLQTTIDSSYAEAVEATWVLSLALKGLYRTLKIHGFQEVQAAFLQSGLLKLLVKKCSKGTGFSKTWLLRDLEILSIMLYSSKKEISSLAEREDTELEEREQDQDVEQSIVGPADVEQNKLDPLEGLDEATKICFLMTHDALNAPLHILRAMYELQMKRTESFFLEVQKRFDGDVITTDERIRTLAQKWQPSKRLKLEEQSSKAVDTDMIILPCLSKPVLCDKATEETNPVAQKLITNTESDLQLSYAKQRRTKSSILLHKELDSRSKKAVRDYLYRVNEATAVLYARHVLASLLAEWPDDVAINEEVLDLSGPAHMTYILDMLMQLEEKQLWEKILQKVLLGCNESMLGTMALTACQFMEEPGMAVQVRESKHPYNNNTNFEDKVQIPGAIYLSIKFDSQCNTEEGCDELLMSSSSDFQQDRHSFSGSPQKWNDFELPGDTLYYRFTSDMSNTEWGYKFTVTAGHLGRFQTVIVPNLPLSGFGFWLFFDLESAFFGVLEICDLDCDLTLLKPLWQLFTHMENNICHDVTKPGILLPLHRALAELFFVTENRVTELGSLQEYLLALNSEDHLHRCTAQALRNIAAISLAINYPNKSTSFWNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TD50</accession>
    <name>A0A8C2TD50_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transmembrane protein 136-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC107324290</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TD50"/>
    <dbReference type="Ensembl" id="ENSCJPT00005015816.1">
        <property type="protein sequence ID" value="ENSCJPP00005010727.1"/>
        <property type="gene ID" value="ENSCJPG00005009294.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000008162"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042512">
        <property type="entry name" value="TLCD5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31898:SF1">
        <property type="entry name" value="TLC DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31898">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="7">
        <location>
            <begin position="28"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005010727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="244" mass="27335" checksum="D96BF9D9562E6A28" modified="2025-10-08" version="2">MALNLCKVLGSLVVWLCLYAAFCLWNKQRSPEWNCRLVTLLHGAIATCLSGYIALWDGPWPLSHAGSPNTALQIHVLSLTLGYFIFDLLWCLYFQTEGDLMLLHHTLSICGMVLVLGLGKSATEVNAVVFVSEITNPLLQTRWFLREMGLYHSFLGEVVDFCFVLLFLVLRIGGGALIMYAMVTAPDPNWILKGGGLAMYIVSLGFMVEICRFVRRKMLKKYHSWMHLKSADAPVKTNGHLAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TDG4</accession>
    <name>A0A8C2TDG4_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Adenylate kinase 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">AK9</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="Ensembl" id="ENSCJPT00005015983.1">
        <property type="protein sequence ID" value="ENSCJPP00005010871.1"/>
        <property type="gene ID" value="ENSCJPG00005009402.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00740000115564"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050145">
        <property type="term" value="F:nucleoside monophosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="185"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="542"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="835"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="542"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="841"/>
            <end position="858"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005010871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1536" mass="177047" checksum="2759C66FF4CDBCC2" modified="2022-01-19" version="1">MASQEEKQSQPFTDIFNEDEAEKSFLLSKPACIIVLGKPCSGKKTLAGKLAQIWKCILIEGKQTLCLEHCIKFIIPFVLEGDTCNLITKLHSHISEELVTEMILKKIESPEVAHFGYVLSGFPSLSEEYMTVSQQMEKIRNLKLKPDFLINIKCSDYDLCQRVSGQRQRPDSGEIYQRNQWDPSLIEKQKKNRDQPEEENEEDEAEAEEMEEETEQDSLKMSEMIDQLVQRPEDMLENIKERVGLYKDTMLRSLENKTHVTSYKNCICIYFRFNKQDELLRVLSSFKLIAPRYRWRRSRWGPVCPVALKNGDIVMGNPELAVSFLGKMYVLSSPEALKMFMLNPRPYLLPPMPMPPCKVLVFGPPLSGRTTVCKLIANKYKGKVGFALKKTVLLEMSELTDLHPEGEEVVEEAVEGSSESEDTLSPETYAEVLERAIAEVKLQNKDRFPGAPEKGGWVVDNFPLSEGHWSALSERGLLPDTVVCLKDTETGVLLYSEGPVTSLLQSKSKSISNLFFGGINILITFSEPFKYRGWELSNEDLDEEAEDLAAEAEAVEDNEAEEEENEEDEEKAKEKKRRMGDTKHFCPVSLKEDYVLYPGLPEHAVKYQEKIYYFSNPEYIDQFLKNPEEYVAHNEPLQAPPLRVCLLGVHGAGKTACARWLADKFGIFHIQFKEYLQELLLPKTKEKIGLDFVEEPEEDDYEIQLQELQGLPQTTTETEDEESKQEVEFTDEEEAIKASLMDAQPLPPEILDNIVPDWWKKEPFRSTGFILDGFPRTPDEAQYLSEQGLCPDIAIYIRIEESDVLDRLLPPRLKKWKERQEKKAENKKKLKDLKAKIRDLEDGENDEGSEEEDETANEDIEAILEEEFFEEEEEEPEEEQEADAIERMQNEILERFESERGGIEGVQEELEKISIPLAEINGSRKLRIVRYQVYCKLNPLVENRRSIFEKCYPISLPLAQKMLVFSYKFPSSFGQWDPVKLKEGEIIKPAQNYENTLFPVIHRQYVYFFSSKKNREIFMNDPIKYICQPKPKPPLPVKIAIVGPPKSGKTTVAKKFESAYGLRRLSMGDAIRFVLNNQPESELGLQLNWHLHRGLTVPDELAIQALDVALLDQVCSTTGVVIDGYPVTKKQVNLLESARIIPVKIIELEMDAKEVFRRALLDKESTDRPSYPVHDSPQILAIKNSYYRQHIDAIRTYYNKERQNWCVIDASQSKWWIWDKVLQEVQGIVKEIQIYLERVREGKAASIADLCITPEELQYRLGEFEQYCPVSLADKGELVDCSVTSSLQFAAEFRAHYYKMASQEELDKFLNRPEIYVPPLAPRPLPPQNKLPQKLTAAEVKALFPKSAEMQGYCPVTYLDGKQRYESLVPGNNEYAAKYQDKLYVFESEEKLLKFMRLPEKYWNLKLPNKLPPVREPILLTALPMAGYLEQGVATSLIKALNEVGCLKPKFPFLSVRRTALLFVACHLKAYNARSPAHRRQMYRRRLERLTEHCELIPYLGREMPREYMEPQHRPLGFDLKLQTFLSLKDYTHSFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TDM9</accession>
    <name>A0A8C2TDM9_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Solute carrier family 25 member 46</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">SLC25A46</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015704947.1">
        <property type="nucleotide sequence ID" value="XM_015849461.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TDM9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005016390.1">
        <property type="protein sequence ID" value="ENSCJPP00005011189.1"/>
        <property type="gene ID" value="ENSCJPG00005009637.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107306360"/>
    <dbReference type="KEGG" id="cjo:107306360"/>
    <dbReference type="CTD" id="91137"/>
    <dbReference type="GeneTree" id="ENSGT00390000015874"/>
    <dbReference type="OrthoDB" id="2403262at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome Z"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061564">
        <property type="term" value="P:axon development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090149">
        <property type="term" value="P:mitochondrial membrane fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055091">
        <property type="term" value="P:phospholipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008535">
        <property type="term" value="P:respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000057">
        <property type="entry name" value="Solute carrier family 25 member 46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039158">
        <property type="entry name" value="SLC25A46"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21252:SF2">
        <property type="entry name" value="MITOCHONDRIAL OUTER MEMBRANE PROTEIN SLC25A46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21252">
        <property type="entry name" value="TB1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="301"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005011189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="408" mass="44714" checksum="18974C899CFCCF82" modified="2022-01-19" version="1">MHPRRPEGFDGLGYRGGGREEPGPGVRPFGGASEMGHWVTTPPDIPGSRNLHWGEKTPPYGAGTPLGAAGLNEEPSLGAGGPGAEQLNRFAGFGIGLASLFTENVLAHPCIVLRRQCQVNYHARNYHLTPFTIVNLMYNINKTQGPRALWKGMGSTFIVQGIALGTEGIVSEFTPLPRELSHKWNLRQIGGHLLLKGLTHVIAMPFYSASLIETVQSEIIRDNPGILDCVKEGIGRVVGMGVPHSKRLLPLMVLIFPTALHGVLHYVISSIVQKLVLLFLKRENSHSLQTESSTSVQSMLDAYFPELIASFAASLCADVMLYPLETVLHRLHIQGTRTIIDNTDLGYEVLPINTQYEGMRDCINTIKREEGMLGFYKGFGSVVVQYTLHVAVLQLTKIIYSTLLQNVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TFF2</accession>
    <name>A0A8C2TFF2_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TFF2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005018676.1">
        <property type="protein sequence ID" value="ENSCJPP00005012957.1"/>
        <property type="gene ID" value="ENSCJPG00005010967.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00960000189567"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47162">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034783646" evidence="1">
        <location>
            <begin position="23"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005012957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="132" mass="14699" checksum="16F8CA0F1ACE27CC" modified="2022-01-19" version="1">MKPNIITTALLLAVSPAELARSGFWEYLSQLTSDKDSLEQAQGSKLGRENLKESLQDRGSNVGNFLEKLAPLNRGIQPRLYHDSDSLRKLIRKELDSLRVRLLPANSWLCTASVCVFVPQLALLENKSSCAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TH83</accession>
    <name>A0A8C2TH83_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CACN subunit beta associated regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CBARP</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TH83"/>
    <dbReference type="Ensembl" id="ENSCJPT00005018150.1">
        <property type="protein sequence ID" value="ENSCJPP00005012535.1"/>
        <property type="gene ID" value="ENSCJPG00005010663.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000009230"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030426">
        <property type="term" value="C:growth cone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030141">
        <property type="term" value="C:secretory granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044325">
        <property type="term" value="F:transmembrane transporter binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903170">
        <property type="term" value="P:negative regulation of calcium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045955">
        <property type="term" value="P:negative regulation of calcium ion-dependent exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037658">
        <property type="entry name" value="CBARP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28597">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL BETA SUBUNIT-ASSOCIATED REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28597:SF1">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL BETA SUBUNIT-ASSOCIATED REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="481"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005012535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="537" mass="57446" checksum="EB6740B7B5B67BAE" modified="2022-01-19" version="1">MNDDSTPWDNATESSTALPGEVSPQDGYVLLLALLSIFIGGTLVLLSGILIICRRCCEADRRHSRASDDPEKTTTTYLDDSQPAQDITIKVEDPECMSASSYRDAESERFLSSSSSSARRVSFNEAALYEQGKKTQEKGRRYTLTEGDFHHLKNARLTHLHLPPPALKIVTIHECESSENSLAMTPRRPPPKPGLAIFQPPGGAVPQPGHAVCPSSALPGDTYNSTAGGSPASSSDSGEGPSFSAAPRSGKGPIAGSGSPGDAPPAPTQGPVLQFFTRLRRHASLDGASPYFRIKKWKLESTQRASSLDTRGSPKRRQFQRQRAASESMDQEDRDPHQTDIIQYIAHTDDVAFHPAGGPFLPSPSSPPPSLGRYFSVDRGDGDGGGGPVHGEGPIFRGRRVRVGSARWGLHSSDGDRPRRDPAAPFPQVRAGRGQSRRGGGPGASQRRSRHLEPPRLAGAVRGVRAKQRPGLGAQRRSGQRLVGRRGPLPLLIPGRGRRPRREALGPAQSGGVGARYPQAAADGQRLRLHRGSGPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TI68</accession>
    <name>A0A8C2TI68_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">E3 ubiquitin-protein ligase LNX</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Numb-binding protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">RING-type E3 ubiquitin transferase LNX</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LNX1</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65.</text>
    </comment>
    <comment type="function">
        <text evidence="14">Isoform 2 provides an endocytic scaffold for IGSF5/JAM4.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 23">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="RefSeq" id="XP_015717757.1">
        <property type="nucleotide sequence ID" value="XM_015862271.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TI68"/>
    <dbReference type="Ensembl" id="ENSCJPT00005018209.1">
        <property type="protein sequence ID" value="ENSCJPP00005012585.1"/>
        <property type="gene ID" value="ENSCJPG00005010702.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107313733"/>
    <dbReference type="CTD" id="84708"/>
    <dbReference type="GeneTree" id="ENSGT00940000158757"/>
    <dbReference type="OrthoDB" id="438726at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098794">
        <property type="term" value="C:postsynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030165">
        <property type="term" value="F:PDZ domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060074">
        <property type="term" value="P:synapse maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd06677">
        <property type="entry name" value="PDZ1_LNX1_2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06678">
        <property type="entry name" value="PDZ2_LNX1_2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06679">
        <property type="entry name" value="PDZ3_LNX1_2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06680">
        <property type="entry name" value="PDZ4_LNX1_2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000198">
        <property type="entry name" value="E3 ubiquitin-protein ligase LNX isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000081">
        <property type="entry name" value="Ligand of Numb protein X 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000120">
        <property type="entry name" value="Ligand of numb-protein X 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000164">
        <property type="entry name" value="Ligand of numb-protein X 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051342">
        <property type="entry name" value="PDZ_scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19964:SF14">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE LNX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19964">
        <property type="entry name" value="MULTIPLE PDZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="19" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034092660" description="E3 ubiquitin-protein ligase LNX" evidence="19">
        <location>
            <begin position="16"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="20">
        <location>
            <begin position="230"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="20">
        <location>
            <begin position="337"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="20">
        <location>
            <begin position="464"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="20">
        <location>
            <begin position="585"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="84"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="139"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00055799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00056865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00073110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00079000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00080597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005012585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="675" mass="74539" checksum="B1A0F3A80C42C90C" modified="2022-01-19" version="1">MKALLLLVLPWLSPANYIDNVGNLHLLYSELCKGASHYGLTKERKRRSQDCSPDRSSSLAVAALSPELSAAAAIALMTDEPGLVNPAFSPTSEDSQSGSGPRDLHSSNHSRTRHFERSTIRSRSFKKINKAFSVLRRTKSGSAVSNQADQEREAVGNSAAGEDSECSIPIPATKTQHSVERPARVTKNKTENLLLSRFSSASLFKDWKNKMVKKGFPRLYHLIPDGEITCIKINRTDPHENLAIRIVGGSETPLVHIIIQHIYRDGVIARDGRLLPGDMILKVNGMDIKNVPHHYALSILKQPCHVLRLTVLREQRYRCRSSGLSLDTHCSRDDSFHVILNKSSPDEQLGIKLVRRADEPGVFIFNLLDGGVAARDGQLQENDRVLAINGHDHRYGSPESAAQLIQASERHVHFVVSRQTRQQPPDILQETGWSYNSSSPQPCPAERINASKSTLHTVTCHEKVVAVRKDHTESLGMTVAGGATNREWDLPIYVISVEPGGVISRDSRIKTGDILLNVNGIDLTGVSRNEAVALLKNTSSSVVLKALEMRTCDGRERSEATEHSEWLPSWVTWLGLPRYLYSCKEIVLRRNTSGSLGFSIVGGYEEHTGNKPFFIKSIVGGTPAYNDGRIRCGDILLAVNGRNTSGMMHACLARMLKELKGKITLTIVSWPGTFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TIV5</accession>
    <name>A0A8C2TIV5_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Hyaluronidase</fullName>
            <ecNumber evidence="13">3.2.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC107308927</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>Random hydrolysis of (1-&gt;4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.</text>
            <dbReference type="EC" id="3.2.1.35"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9 13">Belongs to the glycosyl hydrolase 56 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.35" evidence="13"/>
    <dbReference type="RefSeq" id="XP_015708649.1">
        <property type="nucleotide sequence ID" value="XM_015853163.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TIV5"/>
    <dbReference type="GlyCosmos" id="A0A8C2TIV5">
        <property type="glycosylation" value="1 site, No reported glycans"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005020664.1">
        <property type="protein sequence ID" value="ENSCJPP00005014537.1"/>
        <property type="gene ID" value="ENSCJPG00005012113.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107308927"/>
    <dbReference type="KEGG" id="cjo:107308927"/>
    <dbReference type="GeneTree" id="ENSGT01020000230364"/>
    <dbReference type="OrthoDB" id="5796153at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004415">
        <property type="term" value="F:hyalurononglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030214">
        <property type="term" value="P:hyaluronan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000065">
        <property type="entry name" value="Hyaluronidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018155">
        <property type="entry name" value="Hyaluronidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11769">
        <property type="entry name" value="HYALURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11769:SF9">
        <property type="entry name" value="HYALURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01630">
        <property type="entry name" value="Glyco_hydro_56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038193">
        <property type="entry name" value="Hyaluronidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00846">
        <property type="entry name" value="GLHYDRLASE56"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034466633" description="Hyaluronidase" evidence="14">
        <location>
            <begin position="20"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="11">
        <location>
            <position position="356"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="46"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="210"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="364"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="369"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="428"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR038193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR038193-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038193-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR038193-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU610713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005014537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="478" mass="55367" checksum="348D39608F10DF61" modified="2022-01-19" version="1">MDLWIRWLAVTVLFMMGDAQLPKQAQAPLLLHKPFVVVWNAPTEQCRLRYKVDLDLSIFDIASNTNETLSGSNVTIFYHTHLGYYPYYSDDGDPVNGGVPQNESLIRHLNKAKSDIDYCIPMKKFHGLAVIDWENWRPQWDRNWGNKSIYRNKSLEMVRQRHPQWSEDKIRKVAKEEFENAGKSFMNNTILLAEHMRPNGLWGYYLYPDCYNYDYKEHWQTYTGKCPAIESSRNDLLLWLWKESTALYPSIYLDYILKSSPNAQKFVHYRVKEAIRVASIARKDYVLPVFVYSRPFYAYTFHVLTEIDLVNTIGESAALGAAGVVLWGSMQYASSKESCSTVKRYIDGPLGHYVINVTSAAKLCSKVLCKKNGRCIRKNSDSSAYLHLPPSDFKIQARHSGRGPRLQVTGELSPENKEAMRQMFMCQCYQGWTGIFCELPDQSIMEHSVHIVFSRSRKQKLYVFFLGTMQLLLLYNAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TJN0</accession>
    <name>A0A8C2TJN0_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Dynein cytoplasmic 1 intermediate chain 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">DYNC1I1</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein intermediate chain family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TJN0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005019581.1">
        <property type="protein sequence ID" value="ENSCJPP00005013662.1"/>
        <property type="gene ID" value="ENSCJPG00005011488.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156032"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036464">
        <property type="term" value="C:cytoplasmic ribonucleoprotein granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045503">
        <property type="term" value="F:dynein light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030507">
        <property type="term" value="F:spectrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047496">
        <property type="term" value="P:vesicle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000026">
        <property type="entry name" value="cytoplasmic dynein 1 intermediate chain 2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025956">
        <property type="entry name" value="DYNC1I1/DYNC1I2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050687">
        <property type="entry name" value="Dynein_IC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442:SF34">
        <property type="entry name" value="CYTOPLASMIC DYNEIN 1 INTERMEDIATE CHAIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442">
        <property type="entry name" value="DYNEIN INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11540">
        <property type="entry name" value="Dynein_IC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="152"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="571"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="20"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="598"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="636"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="648"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005013662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="810" mass="89566" checksum="C6FF6BFB44EF5B27" modified="2022-01-19" version="1">MSDKSDLKAELERKKQRLAQIREEKKRKEEERKKKEADLQQKKEPAQEDSDLDRKRRETEALLQSIGISPEPPLVPTPMSPSSKSVSTPSDAGSQDSGDLGPIGRTLQWDTDPSVLQLQSDSELGRRLHKLGVSKITQVDFLPREVVSYSKETQTPLATHQSEEDEDDEEMVEPKAQDDLETENQDQKQETKEGNGQTGTRRKWKQLCKIIAPPRELTEEEKQQVLHSEEFLIFFDRTIRVIERALAEDSDIFFDYSGRDLEEKDGDVQAGANLSFNRQFYDEHWSKHRVVTCMDWSLQYPELMVASYNNNEDAPHEPDGVALVWNMKFKKTTPEYVFHCQSSVMSVCFARFHPNLVVGGTYSGQIVLWDNRSHRRTPVQRTPLSAAAHTHPVYCVNVVGTQNAHNLITVSTDGKMCSWSLDMLSTPQESMELVYNKSKPVAVTGMAFPTGDVNNFVVGSEEGTVYTACRHGSKAGIGEIFEGHQGPVTGINCHMAVGSIDFSHLFVTSSFDWTVKLWTTKHNKPLYSFEDNADYVYDVMWSPVHPALFACVDGMGRLDLWNLNNDTEVRAGGGGAGSHPRGATAPPSSRGHPGPRGGRQDRAGQSKAKRGEAGPPAPPAAGLPRYLRAGGGPAAAGGARLGRAVPRSPSPRAPPAPRSAPPRPHRSAERGGTRLARGFLPSPAFLCKVCSVRRDSEARRRKAKLRFSCIAADCGARGENVTPSPFVSQLLAEAQRPVPCGSLQRPSSKSRIFTSKSRIFPAVPNTHPHVLVISPRPLVISDQNQPNETLQVCTENTETGSPCPLMMVMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TJV7</accession>
    <name>A0A8C2TJV7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cadherin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TJV7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005019470.1">
        <property type="protein sequence ID" value="ENSCJPP00005013572.1"/>
        <property type="gene ID" value="ENSCJPG00005011436.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00960000189372"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013164">
        <property type="entry name" value="Cadherin_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08266">
        <property type="entry name" value="Cadherin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cadherin N-terminal" evidence="2">
        <location>
            <begin position="31"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005013572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="69" mass="7704" checksum="449C88836D1D71CD" modified="2022-01-19" version="1">SLKTWKIPQNCWQRALLCCVLVAAWEAAWGQLRYSVPEELPKGSFVGDVAKDLALELRMCRSAKPTAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TK78</accession>
    <name>A0A8C2TK78_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">TAOK1</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="RefSeq" id="XP_015736047.1">
        <property type="nucleotide sequence ID" value="XM_015880561.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032304313.1">
        <property type="nucleotide sequence ID" value="XM_032448422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TK78"/>
    <dbReference type="Ensembl" id="ENSCJPT00005021562.1">
        <property type="protein sequence ID" value="ENSCJPP00005015179.1"/>
        <property type="gene ID" value="ENSCJPG00005012187.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107322490"/>
    <dbReference type="KEGG" id="cjo:107322490"/>
    <dbReference type="CTD" id="57551"/>
    <dbReference type="GeneTree" id="ENSGT00940000155796"/>
    <dbReference type="OrthoDB" id="10016527at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043014">
        <property type="term" value="F:alpha-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021954">
        <property type="term" value="P:central nervous system neuron development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097194">
        <property type="term" value="P:execution phase of apoptosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007026">
        <property type="term" value="P:negative regulation of microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070050">
        <property type="term" value="P:neuron cellular homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046330">
        <property type="term" value="P:positive regulation of JNK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032874">
        <property type="term" value="P:positive regulation of stress-activated MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000030">
        <property type="entry name" value="Serine/threonine-protein kinase TAO2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000029">
        <property type="entry name" value="Serine/threonine-protein kinase TAO2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051234">
        <property type="entry name" value="TAO_STE20_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47167">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TAO1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47167:SF8">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE TAO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="28"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="323"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="567"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="911"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="375"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="399"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="577"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="975"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1001" mass="115968" checksum="102A5611397AB135" modified="2022-01-19" version="1">MPSTSRAGSLKDPEIAELFFKEDPEKLFTDLREIGHGSFGAVYFARDVRTNEVVAIKKMSYSGKQSNEKWQDIIKEVKFLQRIKHPNSIEYKGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAITHGALQGLAYLHSHNMIHRDIKAGNILLTEPGQVKLADFGSASIASPANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPTLQSNEWSDYFRNFVDSCLQKIPQDRPTSEELLKHMFVLRERPETVLIDLIQRTKDAVRELDNLQYRKMKKLLFQEAHNGPAVETQEEEEEQDHGVGRTGTVNSVGSNQSIPSMSISASSQSSSVNSLPDASDDKSELDMMEGDHTVMSNSSVIHLKPEEENYREESDPRTRASEPQSPPQVSRHKSHYRNREHFATIRTASLVTRQMQEHEQDSELREQMSGYKRMRRQHQKQLMALENKLKAEMDEHRLRLDKDLETQRNNFAAEMEKLIKKHQAAMEKEAKVMANEEKKFQQHIQAQQKKELNSFLESQKREYKLRKEQLKEELNENQSTPKKEKQEWLSKQKENIQHFQAEEEANLLRRQRQYLELECRRFKRRMLLGRHNLEQDLVREELNKRQTQKDLEHAMLLRQHESMQELEFRHLSTIQKMRCELIRLQHQTELTNQLEYNKRRERELRRKHVMEVRQQPKSLKSKELQIKKQFQDTCKIQTRQYKALRNHLLETTPKSEHKAVLKRLKEEQTRKLAILAEQYDHSINEMLSTQALRLDEAQEAECQVLKMQLQQELELLNAYQSKIKMQAEAQHDRELRDLEQRVSLRRALLEQKIEEEMLALQNERTERIRSLLERQAREIEAFDSESMRLGFSNMVLSNLSPEAFSHSYPGASGWSHNPTGGAGPHWGHPMGGPPQAWGHPMQGGPQPWGHPSGPMQGVPRGSAIGVRNSPQALRRTASGGRTEQGMSRSTSVTSQISNGSHMSYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TKI6</accession>
    <name>A0A8C2TKI6_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TKI6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005019544.1">
        <property type="protein sequence ID" value="ENSCJPP00005013635.1"/>
        <property type="gene ID" value="ENSCJPG00005011438.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156683"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000004">
        <property type="entry name" value="Protocadherin 1 gamma 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000001">
        <property type="entry name" value="Protocadherin alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000002">
        <property type="entry name" value="Protocadherin alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000006">
        <property type="entry name" value="Protocadherin alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000129">
        <property type="entry name" value="protocadherin alpha-C2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000018">
        <property type="entry name" value="Protocadherin gamma c3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032455">
        <property type="entry name" value="Cadherin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013164">
        <property type="entry name" value="Cadherin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050174">
        <property type="entry name" value="Protocadherin/Cadherin-CA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028">
        <property type="entry name" value="CADHERIN-87A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028:SF73">
        <property type="entry name" value="PROTOCADHERIN GAMMA-B3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08266">
        <property type="entry name" value="Cadherin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16492">
        <property type="entry name" value="Cadherin_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 12" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="688"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="38"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="140"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="249"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="362"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="459"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="583"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="779"/>
            <end position="803"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005013635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="883" mass="94415" checksum="30860A296E1F568E" modified="2022-01-19" version="1">EGGNCSLLFWRWGRRQRALLCCVLVAAWEAAWGQLRYSVPEELPKGSGSLVGPLARDLGLSPAELPARQLRIVSGDEKRYFVLEEESGNLRVNERIDREGICGDVTPCVFGLETVMENPFNIYHVSITIQDINDNAPRFDKEVVAIELIESTPPGTRLPLGTGRDPDIGVNSLQSYQLTPNPLFSLVVKEDSDGRKHAELLLEKNLDREKQKSHNLILTAVDGGDPVRSGTTQIKIDVTDANDNAPVFTKEIYKVGVPENLPEGSLAFQVKATDGDEGTNAEITYSFNDIASSARQLFSLDPKTGDVRITGPLDYEDVKYYKVTVEGKDGGGLSAHAKVHIDIIDVNDNAPSLTLLPILNPIPEDSVPSTVVAVINVRDRDSGVNGEVTCNLDGDLPFKLEASSESTYKLVIENSLDREEVSTYNITIIATDRGSPALSSRADLVLEVSDVNDNAPVFEEAAYSAYVPENNAAGEPVLRVSARDADAGANGRVSYALAGGGADAAFVSVRAETGELYAQRSFDYERCREFAVEVRARDGGTPARSATATVRVFVLDRNDNAPRVLWPAAGGAEGAGAAAGEAGYLVAKVVAVDADAGRNAWLSYELLQAPEPALFRVGLHSGEVRTTRAVSERDAAKQRLVAVVKDHGQPALSATATLHVVLAESVQDALPELNEDPEAADPQAELRFSLVLALALLSAAFLLSAALTLLTRLRRAGPPAVLRCLGTRRFSASGPAVPADFCEGTLPYSYNLCVAPGRAVPEGAWLLPPALLPSVPVEEPLSGEPCGNRSPSDSAGPGDQPDHLRASQVSNSALFSHCLSFFSSSAQNAESFFLRVSLGSVCRTRCSETLQENKAELHCSCASQRTVNSFSPCLISGHAAGFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TKJ0</accession>
    <name>A0A8C2TKJ0_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">La ribonucleoprotein 6, translational regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LARP6</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015728071.1">
        <property type="nucleotide sequence ID" value="XM_015872585.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TKJ0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005021731.1">
        <property type="protein sequence ID" value="ENSCJPP00005015311.1"/>
        <property type="gene ID" value="ENSCJPG00005012705.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107318583"/>
    <dbReference type="KEGG" id="cjo:107318583"/>
    <dbReference type="CTD" id="55323"/>
    <dbReference type="GeneTree" id="ENSGT00940000159103"/>
    <dbReference type="OrthoDB" id="435402at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048027">
        <property type="term" value="F:mRNA 5'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017022">
        <property type="term" value="F:myosin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035613">
        <property type="term" value="F:RNA stem-loop binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990825">
        <property type="term" value="F:sequence-specific mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032967">
        <property type="term" value="P:positive regulation of collagen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08033">
        <property type="entry name" value="LARP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12289">
        <property type="entry name" value="RRM_LARP6"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="La ribonucleoprotein domain family member 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034880">
        <property type="entry name" value="LARP6_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002344">
        <property type="entry name" value="Lupus_La"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024642">
        <property type="entry name" value="SUZ-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792:SF71">
        <property type="entry name" value="LA-RELATED PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12901">
        <property type="entry name" value="SUZ-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00302">
        <property type="entry name" value="LUPUSLA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51938">
        <property type="entry name" value="SUZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="6">
        <location>
            <begin position="77"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="SUZ-C" evidence="7">
        <location>
            <begin position="418"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="278"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="455"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="291"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="322"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="342"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="364"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="411"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="430"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="474"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="484" mass="53971" checksum="92F9F97D397D1064" modified="2022-01-19" version="1">MAQRQHGAEELGAARPELAASGGPVQIRVAAEEEEEEEEGARCPAARGGGSCSEEESGRCGRSSGGENDDDSDQNWKPPENDLIQKLIAQIEYYFSDENLEKDAFLLKHVRRNKMGYVSVKLLTSFKKVKHLTRDWRTTAHALKYSDMLELNDDNRKVRRNTPVPVFPSENLPTRMLLVYDIHMISELQVLNKQENGCVQEKVMEYLLKAFVNFGVISSVRILKPGRDLPPDIRRFSSRYTQMGTQECAIVEFEEVDAAVQAHEFMCAEKKETGMKVVLIGTKPPKKKVPKDKNRDEDNNKSLKKVRSLNKRVEELQFTGDESSANSSSEPESNPTSPLSGRRNTVTSTTSKLSPVVHPNNHLSPNVSPRSSPWNSPSSLRKVTKKSPLAEDSKLNLSTSPEIPRKCTDYSSDSSITPSGSPWVQRRKAQTTTQEKSPVSSPMLARKIQNADGLPVGVLRLPRGPDGTKGFHSGCERRKAMKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TKZ9</accession>
    <name>A0A8C2TKZ9_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Collagen alpha-2(VI) chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">COL6A2</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Collagen VI acts as a cell-binding protein.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Trimers composed of three different chains: alpha 1(VI), alpha 2(VI), and alpha 3(VI).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the type VI collagen family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015723178.1">
        <property type="nucleotide sequence ID" value="XM_015867692.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TKZ9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005021861.1">
        <property type="protein sequence ID" value="ENSCJPP00005015413.1"/>
        <property type="gene ID" value="ENSCJPG00005012779.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107316360"/>
    <dbReference type="KEGG" id="cjo:107316360"/>
    <dbReference type="CTD" id="1292"/>
    <dbReference type="GeneTree" id="ENSGT00940000155682"/>
    <dbReference type="OrthoDB" id="9944853at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005518">
        <property type="term" value="F:collagen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051402">
        <property type="term" value="P:neuron apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043491">
        <property type="term" value="P:phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009411">
        <property type="term" value="P:response to UV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00198">
        <property type="entry name" value="vWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000027">
        <property type="entry name" value="collagen alpha-2(VI) chain isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000052">
        <property type="entry name" value="collagen alpha-2(VI) chain isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000026">
        <property type="entry name" value="Collagen, type VI, alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.320">
        <property type="entry name" value="6-Phosphogluconate Dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052229">
        <property type="entry name" value="Collagen-VI/PIF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22588">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22588:SF15">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00453">
        <property type="entry name" value="VWFADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="7" id="KW-0176">Collagen</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0379">Hydroxylation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034129319" description="Collagen alpha-2(VI) chain" evidence="15">
        <location>
            <begin position="28"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="16">
        <location>
            <begin position="46"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="16">
        <location>
            <begin position="615"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="16">
        <location>
            <begin position="833"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="263"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="287"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="306"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="363"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="534"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="551"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00043858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00065069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00070549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1022" mass="109100" checksum="9AFDBF292136BAD4" modified="2022-01-19" version="1">MSRRTAEMFQQAFLSALLCVALVPLHAQFDDEPVTSCTEKTDCPISVYFVIDTSESIALQTVPIQSLVDQIKQFIPLFIERLENEVYQNQVSITWMFGGLHYSDVVEIYSPLTRSKDTYLTKLRAIKYLGRGTFTDCAISNMTQQFQSQTARDVKFAVVITDGHVTGSPCGGMKMQAERARDMGIKLFAVAPSEDVYEQGLREIASPPHDLYRSNYTITPKDALHIDENTIERIIKAMKHEAYAECYKMSCLEIAGPAGPKGYRGQKGAKGNMGEPGSPGLKGRQGDPGIEGPIGYPGPKGVPGLKGEKGEIGSDGRRGAAGLAGRNGTDGQKGKLGRIGPPGCKGDRGDKGPDGYPGDAGDQGERGDEGMKGDPGRPGRSGPPGPPGEKGSPGIPGNPGAQGPGGSKGRKGETGPPGPKGEPGRRGDPGTKGSKGGPGTKGERGDPGPEGPRGLPGEIGNKGARGDQGLPGPRGPTGAVGEPGNTGSRGDPGDLGPRGDAGPPGPKGDRGRPGFSYPGPRGPQGDKGEKGQPGPKGGRGELGPKGTQGTKGEKGEEGDPGPRGEPGSRGPPGEAGPEGTPGPPGDPGLTDCDVMTYVRETCGCCDCEKRCGALDIMFVIDSSESIGYTNFTLEKNFVVNVVSRLGSIAKDPKSETGARVGVVQYSHEGTFEAIKLDDERINSLSSFKEAVKRLEWIAGGTWTPSALQFAYNKLIKESRREKAQVFAVVITDGRYDPRDDDKNLGALCGRDVLVNTIGIGDIFDQPEQSETLVSIACNEPQRVQKMRLFSDLVAEEFIDKMEDMLCPDPQIVCPELPCQTELAVAQCTQRPVDIVFLLDGSERIGEQNFHRAHHFVEQVAQQLTLARRNDDNMNARIALLQYGSEREQDVVFPLTYNLTEISNALAQIKYLDSSSNIGSAIIHAINNIVLSPGSGQRVARRNAELSFVFITDGITGSKNLEEAINSMKKQDVMPTVVALGSDVDMDVLLKLGLGDRAAIFREKDYESLSQPSFFDRFIRWIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TM09</accession>
    <name>A0A8C2TM09_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Calcium voltage-gated channel subunit alpha1 I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">CACNA1I</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="Ensembl" id="ENSCJPT00005022452.1">
        <property type="protein sequence ID" value="ENSCJPP00005015899.1"/>
        <property type="gene ID" value="ENSCJPG00005010236.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158594"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008331">
        <property type="term" value="F:high voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019228">
        <property type="term" value="P:neuronal action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030431">
        <property type="term" value="P:sleep"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000018">
        <property type="entry name" value="Voltage-dependent T-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000053">
        <property type="entry name" value="Voltage-dependent T-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000054">
        <property type="entry name" value="Voltage-dependent T-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000007">
        <property type="entry name" value="Voltage-dependent T-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000008">
        <property type="entry name" value="Voltage-dependent T-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000009">
        <property type="entry name" value="Voltage-dependent T-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000012">
        <property type="entry name" value="Voltage-dependent T-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050599">
        <property type="entry name" value="VDCC_alpha-1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005445">
        <property type="entry name" value="VDCC_T_a1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628:SF39">
        <property type="entry name" value="VOLTAGE-DEPENDENT T-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01629">
        <property type="entry name" value="TVDCCALPHA1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="3" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="216"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="380"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="623"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="661"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="744"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="822"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1134"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1172"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1209"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1272"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1371"/>
            <end position="1394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1450"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1487"/>
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    <feature type="transmembrane region" description="Helical" evidence="17">
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            <begin position="1585"/>
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    <feature type="transmembrane region" description="Helical" evidence="17">
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            <begin position="1671"/>
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            <begin position="91"/>
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        </source>
    </evidence>
    <sequence length="2193" mass="245507" checksum="F99823A33AAA8077" modified="2022-01-19" version="1">MAECIPQPPPTWSAGPQPHNTSAACPLEPVNMEVSEQQMPLEQPLSSPELGEDEEVTSPPDPDVPYPDLAPVVFFCLKQTTSPRSWCIKMCVSMMVILLNCVTLGMYQPCEDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFMEENFTIQGDIVLPPYYQPEEDDEMPFICSLSGDNGIMGCHEIPPLKERGHECCLDKDDYYYYNSVRQEFNVSGMCVNWNQYYNVCRTGNANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRENQLMQEQRARYLSSSTVASYMEPGDCYEEIFQYVCHIMRKAKRRTLGLYNSIQSRRQGHIEPSEAKQGISRQKQRHYSKDESGNVSSGNGSVTGSRMCQQHNPLDRPPQGLVQPIAVTATSDLTNCPQCHRGEHDTSRRLSVLDSADSDQEDGGDSEAEGEGCRGDQSASALEKEEEEVEEGGRMKLCSDMWREVRVKLRGIVDSKYFNRGIMIAILVNTISMGIEHHEQPEELTNILEISNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIIGQSDGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLKTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSYSEEDQSSSNMEELDQFQEIQEGSDPKLFAISVTPNGHLDPSLPSSNAPVAAGRVSNSSRNSLQPDQICVAVGSRKSSVMSLGRMTYDQRSLSSSRSSHYGAWGRSGAWGSRRSSWNSLARGHSLKHKPPSAEHESLLSRERHRAGDRELDGAERVFHHRRTLSLDNKGSCDLLELASIPSGHRGTCRPGTTSGGSDHQDCNGKMPSIAKEIFPRMNNHKERGEDDEEIDYSLCFRIRKMMEVYKPDWCELREDWSIYLFSPQNRFRLLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEHRSMERIFLTVSNYIFTAIFVAEMTLKVVSLGLYFGDQAYLRSSWNVLDGFLVFVSLIDIVVSVASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLGVDIRNITNRSDCVAANYKWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNNNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLEKKRRKAQRLPYYATYCPIRLLIHSVCTSHYLDIFITFIICLNVVTMSLEHYNQPVSLETALKYCNYLFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFRVSTGDNWNGIMKDTLRDCSHDDRSCLSNLQFISPLYFVTFVLTAQFVLVNVVVAVLMKHLEESNKEAKEDAEMDAEIELEFAHGLCSRKSASSKSRQGKGAGTGGGGGRTEPEGRLCTRCYSPAQENLWLDSVSLIIKDSFDGELMIIDNLSGSVFHHYSSPAMCEKCNHDKQEVQLAEMEALSLNSDKSSSILLGDESDNRSTSQLSPKETKAGDLGECLLPISSTDGSTNPDSYLCEIEKTPFNSVQSWLKHEGTKAPSSPFSPGTSCPLLPVPAEFFHPAISAAQTGPEKVSCTHNLPKISLQGSWASLRSPSVNCSLLRQAHESDTSLDSRSSSSVGSLQTTLEDSLNLSDSPQCALDLPVALCPMPATSDPRPLAAPLSPTSCRRSLRGRGLFTLRSIRQHQRSHSSGGSTSPGCTHHDSMDPSDEEGAGSSLRGGGNNSEPSETLSSLSLTSLFSPPPPGLTLGKKCSSTSSLHASPSPCRPTAHHTKPFYTVDPKGFLSMPSWVTDFCKDTPPPVQGAEPDGPSRLGTRECSSPLPSELELGDGVSKKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TMX5</accession>
    <name>A0A8C2TMX5_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AB hydrolase superfamily. ABHD14 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TMX5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005020805.1">
        <property type="protein sequence ID" value="ENSCJPP00005014641.1"/>
        <property type="gene ID" value="ENSCJPG00005012196.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161296"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46197:SF1">
        <property type="entry name" value="PROTEIN ABHD14A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46197">
        <property type="entry name" value="PROTEIN ABHD14B-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="35"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005014641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="100" mass="11052" checksum="50402897F41076F1" modified="2022-01-19" version="1">MSGRFALPFLLAHSEQLAGFVPIAPVGTREYSTVQYQQVQTPTLILYGDRDTGLGHQALQSLQHLPKHRVVVLPGAGHACYMDKPEDFHRALLGFLGQLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TN33</accession>
    <name>A0A8C2TN33_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TN33"/>
    <dbReference type="Ensembl" id="ENSCJPT00005021557.1">
        <property type="protein sequence ID" value="ENSCJPP00005015174.1"/>
        <property type="gene ID" value="ENSCJPG00005012612.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155136"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd06673">
        <property type="entry name" value="PDZ10_MUPP1-PDZ8_PATJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06674">
        <property type="entry name" value="PDZ11_MUPP1-PDZ9_PATJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06675">
        <property type="entry name" value="PDZ12_MUPP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06676">
        <property type="entry name" value="PDZ13_MUPP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06672">
        <property type="entry name" value="PDZ8_MUPP1-PDZ7_PATJ-PDZ2_INAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000038">
        <property type="entry name" value="Multiple PDZ domain protein isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000058">
        <property type="entry name" value="multiple PDZ domain protein isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000110">
        <property type="entry name" value="multiple PDZ domain protein isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051342">
        <property type="entry name" value="PDZ_scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19964:SF11">
        <property type="entry name" value="INAD-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19964">
        <property type="entry name" value="MULTIPLE PDZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="1">
        <location>
            <begin position="47"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="1">
        <location>
            <begin position="217"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="1">
        <location>
            <begin position="313"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="1">
        <location>
            <begin position="434"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="1">
        <location>
            <begin position="560"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="643" mass="68694" checksum="0B88AD96FE494341" modified="2022-01-19" version="1">MGFFAKADANWLPSARQRAGKQYQLEGGVQLKKIRQRYADLPGELHIIELEKDKNGLGLSLAGNKDRSRMSIFVVGINPDGPAGRDGRMHIGDELLEINNQILYGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQMAVTPFPLPTSTHPSIEVRFVLKQMKQSKSSAKAPVNLQEIPLVSAPSYLSPDTEITNRNVLPPPLPVDPATCPIVPGQEMTIEISKGRSGLGLSIVGGKDTPLDAIVIHEVYEEGAAARDGRLWAGDQILEVNGIDLRNASHEEAITALRQTPQKVQLVVYRDEAHYKDEENLEIFHVDIQKKTGRGLGLSIAGKRNGSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATTLKCAQGLVHLELGRLRAGSWLASRKTSQNSQVNQQSTHSHFHPALAPVLSTLQNFVSTRRSSADGPNDALGISIAGGKGSPLGDIPIFIAMIQASGVAARTQRLRVGDRIVSLNGQPLDGLSHADAVNLLKNAYGSIILQVVADTNISAIATQLESMSAGCNVNSSSERASEDPEAPQPKIITLEKGSDGLGFSIVGGYGSPHGDLPIYVKTIFAKGAAADDGRLKRGDQILAVNGEALEGVTHEQAVAILKRQKGTVTLSVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TNG4</accession>
    <name>A0A8C2TNG4_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Insulin like growth factor 2 mRNA binding protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">IGF2BP3</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RRM IMP/VICKZ family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TNG4"/>
    <dbReference type="SMR" id="A0A8C2TNG4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005021350.1">
        <property type="protein sequence ID" value="ENSCJPP00005015024.1"/>
        <property type="gene ID" value="ENSCJPG00005012087.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154957"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048027">
        <property type="term" value="F:mRNA 5'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990247">
        <property type="term" value="F:N6-methyladenosine-containing RNA reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070934">
        <property type="term" value="P:CRD-mediated mRNA stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22490">
        <property type="entry name" value="KH-I_IGF2BP1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22498">
        <property type="entry name" value="KH-I_IGF2BP3_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12627">
        <property type="entry name" value="RRM1_IGF2BP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12630">
        <property type="entry name" value="RRM2_IGF2BP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000203">
        <property type="entry name" value="insulin-like growth factor 2 mRNA-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.210:FF:000001">
        <property type="entry name" value="insulin-like growth factor 2 mRNA-binding protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000026">
        <property type="entry name" value="Insulin-like growth factor 2 mRNA-binding protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000027">
        <property type="entry name" value="insulin-like growth factor 2 mRNA-binding protein 3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000099">
        <property type="entry name" value="insulin-like growth factor 2 mRNA-binding protein 3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="2"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="81"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="160"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="184"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="587" mass="64797" checksum="0B086E8F8FF21D3C" modified="2022-01-19" version="1">MNKLYIGNLGENVSPLDLESLFKDSKIPFSGQFLVKSGYAFVDCPDENWAMKAIETLSGKVELHGKLIEVEHSVPKRQRSRKLQIRNIPPHLQWEVLDSLLAQYGTVENCEQVNTDTETAVVNVTYGNKDQARQAIEKLNGFQLENYSLKVAYIPDEMAAQQPPQQHPQGRRGFGQRGPPRQGSPSAATRQKPQSDVPLRMLVPTQFVGAIIGKEGATIRNITKQTQSKIDIHRKENAGAAEKPITIHSTPEGCSTACKIIMEIMQKEAQDTKFTEEIPLKILAHNNFVGRLIGKEGRNLKKIEQDTDTKITISPLQDLTLYNPERTITVKGSIETCAKAEEEIMKKIRESYENDIAAMNLQAHLIPGLNLNALGLFPPSSSGIPPPAVSVASAAAAASYPPFGVRRQQPESETVHLFIPALAVGAIIGKQGQHIKQLSRFAGASIKIAPAEGPDAKLRMVIITGPPEAQFKAQGRIYGKLKEENFFGPKEEVKLEAHIKVPSYAAGRVIGKGGKTVNELQNLTSAEVVVPRDQTPDENDQVVVKITGHFYACQLAQRKIQEILAQVRRQQQQQKTLQSGQPQPRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TNZ1</accession>
    <name>A0A8C2TNZ1_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat and kinase domain containing 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ANKK1</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TNZ1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005022128.1">
        <property type="protein sequence ID" value="ENSCJPP00005015633.1"/>
        <property type="gene ID" value="ENSCJPG00005012929.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162060"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010564">
        <property type="term" value="P:regulation of cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF175">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="21"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="339"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="372"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="405"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="438"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="471"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="504"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="537"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="570"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="603"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="636"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="669"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="760" mass="85136" checksum="5A9DC3462295BB9B" modified="2022-01-19" version="1">MASGTEQQCGSLTVFSKEDFEEDWVKVASGGFGCVYQVKHKKWRTVYAVKCSPYLLQDPGMESVNCLMEEATKMEKIKFQHIVTIYGVCNSPLGIVMEYMSRGSLEKILPTHKMSWQLKFRVIHEMGLAMNFLHSMTPPLLHLDLKPGNILLDGNMHVKISDFGLSRWMEQSSRMQYIESSALRGTLSYIPPEMFLQNTKPPGIKYDVYSFGIVIWEVLMQKKPYAGANMMAIIVRVAAGKRPCLEPISDDWPGECQQMVDLMKRCWNQDPKQRPSFTDIPVETDMLLSLIQSLVVDPENERLVRKMSHKPEVHVPPSHSEMESPEDILCEEIWRVHENGLTLLHFMVIQGNVEKVKFLLSCKANVNSQAVCGYTPLIVAVQKRSPEICSVLIEHGADTNMPDEDGWTPLHFAAQNGDDRIVRLLLDHQAHVNAQEHDGWTPLHLASQNNFENVARVLLSRQADSNTQEVDGKTALHVAACFGHVGLVKLLASQGADLEKKQKNHRTPLHVAVERGKFRVVHYLLKNGASVNSLDQNHYSALHLAVVRGKYLICEKLIKYGANVELRTDKGWTPLHLASFKGHIEIIHLLKDSCAKLNARGSMGWTPLHLATRYSEEPVVCELLRCGADPNITEKSEWAPLHFAVQRGSFLTVINLLECRADVNVKNKVGWTPLHLAVLKGNMAIIKTLIKAGALLNVEDITGCTALQLAIRHQKENIITLLQGKDSAGGGLLPGREKLGNLLLWEQSSVCCWCVGIACN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TPT2</accession>
    <name>A0A8C2TPT2_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transformation/transcription domain associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TRRAP</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family. TRA1 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015732288.1">
        <property type="nucleotide sequence ID" value="XM_015876802.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005023879.1">
        <property type="protein sequence ID" value="ENSCJPP00005017089.1"/>
        <property type="gene ID" value="ENSCJPG00005013616.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107320679"/>
    <dbReference type="CTD" id="8295"/>
    <dbReference type="GeneTree" id="ENSGT00390000017961"/>
    <dbReference type="OrthoDB" id="5570127at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05163">
        <property type="entry name" value="PIKK_TRRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046807">
        <property type="entry name" value="Tra1_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046805">
        <property type="entry name" value="Tra1_ring"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF1">
        <property type="entry name" value="TRANSFORMATION_TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20175">
        <property type="entry name" value="Tra1_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20206">
        <property type="entry name" value="Tra1_ring"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAT" evidence="4">
        <location>
            <begin position="2663"/>
            <end position="3235"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="3">
        <location>
            <begin position="3478"/>
            <end position="3801"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="5">
        <location>
            <begin position="3805"/>
            <end position="3837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1994"/>
            <end position="2021"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2513"/>
            <end position="2549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="3245"/>
            <end position="3267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2003"/>
            <end position="2015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2513"/>
            <end position="2525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="3247"/>
            <end position="3263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005017089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="3837" mass="435237" checksum="2B889C71246113C4" modified="2022-01-19" version="1">MAFVSAQGPTVVDQTTLMKKYLQFVAALTDVNTPDETKLKMMQEVSENFENVTSSPQYSTFLEHIIPRFLTFLQDGEVQFLQEKPAQQLRKLVLEIIHRIPTNEHLRLHTKNILSVMFRFLETENEENVLICLRIIIELHKQFRPAITQEIHHFLDFVKQIYKELPKVVGRYFENPQVIPENTVPPPEMVGMITTIVVKVNPEREDSETRTHSIIPRGSLSLKVLAELPIIVVLMYQLYKLNIHNVVAEFVPLIMNTIIIQVSAQARQHKLYNKELYADFIAAQIKTLSFLAYIIRIYQELVAKYSQQMVKGMLQLLSNCPAETAHLRKELLIAAKHILTTDLRSQFIPCMDKLFDESILIGSGYTARETLRPLAYSTLADLVHHVRQHLPLNDLSLAVQLFAKNIDDESLPSSIQTMSCKLLLNLVDCIRSKSEQENGNGRDILMRMLEVFVLKFHTIARYQLSGIFKKCKPQSELGAAEAALPGVPTAANAAPVPVPSPAPATPVAPAPVPVFEKQGEKEKEDKQTFQVTDCRSLVKTLVCGVKTITWGITSCKAPGEAQFIPNKQLQPKETQIYIKLVKYAMQALDIYQVQIAGNGQTYVRVANCQTVRMKEEKEVLEHFAGVFTMMNPLTFKEIFQTTVPYMVERISKNYALQIVANSFLANPTTSALFATILVEYLLDRLPEMGSNVELSNLYLKLFKLVFGSVSLFAAENEQMLKPHLHKIVNSSMELAQTAKEPYNYFLLLRALFRSIGGGSHDLLYQEFLPLLPNLLQGLNMLQSGLHKQHMKDLFVELCLTVPVRLSSLLPYLPMLMDPLVSALNGSQTLVSQGLRTLELCVDNLQPDFLYDHIQPVRAELMQALWRTLRNPADSISHVAYRVLGKFGGSNRKMLKESQKLQYVVTEIQGPSITIEFSDCKASIQLPMEKAIETALDCLKSANTEPYYRRQAWEVIKCFLVAMMSLDDNKHALYQLLAHPNFTEKSIPSVIISHRYKAQDTPARKTFEQALTGAFMSAVIKDLRPSALPFVASLIRHYTMVAVAQQCGPFLLQCYQVGSQPSTAMFHSEENGSKGMDPLVLIDAIAICMAYEEKELCKIGEVALAVIFDVASIILGSKERACQLPLFSYIVERLCACCYEQAWYAKLGGVVSIKFLMERLPLIWVLQNQQTFLKALLFVMMDLTGEVSNGAVAMAKTTLEQLLIRCATPLKDEEKTEEIIAAQEKSFHHVTHDLVREVTSPNSTVRKQAMHSLQVLAQVTGKSVTVIMEPHKEVLQDMVPPKKHLLRHQPANAQIGLMEGNTFCTTLQPRLFTMDLNVVEHKVFYTELLNLCEAEDSALMKLPCYKSLPSLVPLRIAALNALAACNYLPQSREKIIAALFKALNSTNNELQEAGEACMRKFLEGATIEVDQIHTHMRPLLMMLGDYRSLTLNVVNRLTSVTRLFPNSFNDKFCDQMMQHLRKWMEVVVITHKGGQRSDGNEMKICSAIINLFHLIPAAPQTLVKPLLEVVMKTERAMLIEAGSPFREPLIKFLTRHPSQTVELFMMEATLNDPQWSRMFMSFLKHKDAKPLRDVLAANPNRFITLLLPAGTQATVRPGSPSTTTMRLDLQFQAIKIISIIVKNDECWLANQHSLVSQLKRVWVSEAFQERHRKENMAATNWKEPKLLAYCLLNYCKRNYGDIELLFQLLRAFTGRFLCNMTFLKEYMEEEIPKNYSIPQKRALFFRFVDFNDPNFGDELKAKVLQHILNPAFLYSFEKGEGEQLLGPPNPEGDNPESITSVFITKVLDPEKQADMLDSLRIYLLQFATLLVEHAPHHIHDNNKNRNSKLRRLMTFAWPCLLSKACVDPACKYSGHLLLAHIIAKFAIHKKIVLQVFHSLLKAHAMEARAIVRQAMAILTPAVPARMEDGHQMLTHWTRKIIVEEGHTVPQLVHILHLIVQHFKVYYPVRHHLVQHMVSAMQRLGFTPSVTIEQRKLAVDLAEVVIKWELQRIKDQQPDSDMDPSASGEGASSTSSAVKRGLSVDSGQEVKRFRTATGAISAVFGRSQSLPGADALLSKPIDKQHTDTVVNFLIRIACQVNDNSNTAGSPGELLSRRCVNLLKTALRPDMWPKSELKLQWFDKLLMTVEQPNQANFANICTGLEVLSFLLTVLQPPAILSSFKPLQRGVAACMTCGNTKVLRAVHSLLSRLMGIFPTEPSTSSVASKYEELECLYAAVGKVIYEGLTNYEKATNANPSQLFGTLMILKSACSNNPSYIDRLISVFMRSLQKMVREHLNPQATAGAAETNTAGTSELVMLSLDLVKTRLAVMSMEMRKNFIQAILTSLIEKSTDAKILRAVVKIVEEWVKNNSPMAANQTPTLREKSILLVKMMTYIEKRFPEDLELNAQFLDLVNYVYRDENLSGSELTAKLEPAFLSGLRCAQPLIRAKFFEVFDNSMKRRVYERLLYVTCSQNWEAMGNHFWIKQCIELLLAVCERNTTIGTSCQGAMLPSITNVINLADSHDRAAFAMVTHVKQEPRERENSESKEEDVEIDIELAPGDQTSTPKTKELSEKDIGNQLHMLTNRHDKFLDSLREVKTGALLSAFVQLCHISTPLAEKTWIQLFSRLWKILSDRQQHALAGEISPFLCSGSHQVQRDCQPSALNCFVEAMSQCVPPIPIRPCVLKYLGKTHNLWFRSTLMLEHQAFEKGLSLQIKPKQTTEFYEQESITPPQQEILDSLAELYSLLQEEDMWAGLWQKRCKFPETATAIAYEQHGFFEQAQESYEKAMEKAKKEHERNNASPSIFPEYQLWEDHWIRCSKELNQWEPLTEYGQSKGHINPYLVLECAWRVSNWTAMKEALVQVELSCPKEMAWKVNMYRGYLAICHPEEQQLNFIERLVEMASSLAIREWRRLPHVVSHVHTPLLQAAQQIIELQEAAQINAGLQPTNLGRNNSLHDMKTVVKTWRNRLPIVSDDLSHWSSIFMWRQHHYQAIVTAYENSSQHDPSSNNAMLGVHASASAIIQYGKIARKQGLVNVALDILSRIHTIPTVPIVDCFQKIRQQVKCYLQLAGVMGKNECMQGLEVIESTNLKYFTKEMTAEFYALKGMFLAQINKSEEANKAFSAAVQMHDVLVKAWAMWGDYLENIFVKERQLHLGVSAITCYLHACRHQNESKSRKYLAKVLWLLSFDDDKNTLADAVDKYCIGVPPIQWLAWIPQLLTCLVGSEGKLLLNLISQVGRVYPQAVYFPIRTLYLTLKIEQRERYKSDSGQQQPSSVGNQSHSASDPGPIRATAPMWRCSRIMHMQRELHPTLLSSLEGIVDQMVWFRENWHEEVLRQLQQGLAKCYSVAFEKSGAVSDAKITPHTLNFVKKLVSTFGVGLENVSNVSTMFSSAASESLARRAQATAQDPVFQKLKGQFTTDFDFSVPGSMKLHNLISKLKKWIKILEAKTKQLPKFFLIEEKCRFLSNFSAQTAEVEIPGEFLMPKPTHYYIKIARFMPRVEIVQKHNTAARRLYIRGHNGKIYPYLVMNDACLTESRREERVLQLLRLLNPCLEKRKETTKRHLFFTVPRVVAVSPQMRLVEDNPSSLSLVEIYKQRCAKKGIEHDNPISRYYDRLATVQARGTQASHQVLRDILKEVQSNMVPRSMLKEWALHTFPNATDYWTFRKMFTIQLALIGFAEFIFHLNRLNPEMLQIAQDTGKLNVAYFRFDINDATGDLDANRPVPFRLTPNISEFLTTIGVSGPLTASMIAVARCFAQPNFKVDGILKTVLRDEIIAWHKKTQEDTSSPLSAAGQPENMDSQQLVSLVQKAVTAIMTRLHNLAQFEGGESKVNTLVAAANSLDNLCRMDPAWHPWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TSA5</accession>
    <name>A0A8C2TSA5_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Coronin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Regulates leading edge dynamics and cell motility in fibroblasts. May be involved in cytokinesis and signal transduction.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Forms homooligomers, but does not form complexes with the other coronins. Interacts with Arp2/3 complex components, including ACTR2, ARPC1B and ARPC2. Binds actin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Stress fiber</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the WD repeat coronin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TSA5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005022478.1">
        <property type="protein sequence ID" value="ENSCJPP00005015922.1"/>
        <property type="gene ID" value="ENSCJPG00005013136.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159031"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:003604">
        <property type="entry name" value="Coronin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015505">
        <property type="entry name" value="Coronin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015048">
        <property type="entry name" value="DUF1899"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856:SF24">
        <property type="entry name" value="CORONIN-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08953">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01166">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 12 13" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="DUF1899" evidence="15">
        <location>
            <begin position="5"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="78"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="251"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="255"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU280818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="286" mass="31164" checksum="0EC729594BD9649B" modified="2022-01-19" version="1">MSFRKVVRQSKFRHVFGQPVKTDQCYDDIRVSRVTWDSTFCAVNPSFVAIIVEASGGGAFLVLPLHKTGRIDKSYPTVCGHTGPVLDIEWCPHNDHVIASGSEDCTVMVWQVPEGGLVQPLTEPVVVLEGHSKRVGIISWHPTARNVLLSAGMGMVLGHGVCCWRLEDMHTDLIYNVGWNRNGSLLCTTCKDKKVRVIDPRRGTVLLVSGRVPMSPACFPSHPLSPGAPLDAHNPLSPCCAPPVSHLCPHPVPPPRRRRSGRTRVRAPCAPSSWLMARSSPPASAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TTI1</accession>
    <name>A0A8C2TTI1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nucleoporin NUP53</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">NUP35</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Functions as a component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Nup35 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015723423.1">
        <property type="nucleotide sequence ID" value="XM_015867937.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TTI1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005023606.1">
        <property type="protein sequence ID" value="ENSCJPP00005016875.1"/>
        <property type="gene ID" value="ENSCJPG00005013831.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107316450"/>
    <dbReference type="CTD" id="129401"/>
    <dbReference type="GeneTree" id="ENSGT00390000005923"/>
    <dbReference type="OrthoDB" id="3365060at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044613">
        <property type="term" value="C:nuclear pore central transport channel"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044615">
        <property type="term" value="C:nuclear pore nuclear basket"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990830">
        <property type="term" value="P:cellular response to leukemia inhibitory factor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006607">
        <property type="term" value="P:NLS-bearing protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12722">
        <property type="entry name" value="RRM_Nup53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000095">
        <property type="entry name" value="Putative Nucleoporin NUP53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017389">
        <property type="entry name" value="Nucleoporin_NUP53"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007846">
        <property type="entry name" value="RRM_NUP35_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21527">
        <property type="entry name" value="NUCLEOPORIN NUP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21527:SF6">
        <property type="entry name" value="NUCLEOPORIN NUP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05172">
        <property type="entry name" value="RRM_Nup35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038119">
        <property type="entry name" value="Nucleoporin_NUP53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51472">
        <property type="entry name" value="RRM_NUP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7 9 10" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="8 9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 9 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RRM Nup35-type" evidence="12">
        <location>
            <begin position="168"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR038119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005016875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="324" mass="34440" checksum="7E88B2B70EC0148D" modified="2022-01-19" version="1">MAGFAMDPPPAVEPMTLGSPTSPKPGTSAQFLPGFLMGDLPAPVTPQPRALSGPAVGAMDVRSPLLAGGSPPQPVVPTHKDKSGAPPVRSIYDELSSPGLGSSPLTSRRAGSFSLTQSPLVGNISSTPGTASSMFSPASIGQPRKTTLSPAQLDPFYTQGDSLTSEDQLDDTWVTVFGFPQASASYILLQFAQYGNILKHVMSNTGNWMHIRYQSKLQARKALSKDGRIFGESIMIGVKPCIDKSVMENFERSSASSMSSVFTPPSKTIGTPVQLANTTKISTMRPLATAYKASTSDYQVVSDRQTPKKDESIVSKAMEYVFGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TUK7</accession>
    <name>A0A8C2TUK7_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">cAMP responsive element binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">CREB1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015723683.1">
        <property type="nucleotide sequence ID" value="XM_015868197.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015723684.1">
        <property type="nucleotide sequence ID" value="XM_015868198.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TUK7"/>
    <dbReference type="SMR" id="A0A8C2TUK7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005026203.1">
        <property type="protein sequence ID" value="ENSCJPP00005018907.1"/>
        <property type="gene ID" value="ENSCJPG00005015351.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107316551"/>
    <dbReference type="KEGG" id="cjo:107316551"/>
    <dbReference type="CTD" id="1385"/>
    <dbReference type="GeneTree" id="ENSGT00940000155408"/>
    <dbReference type="OrthoDB" id="5970722at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990589">
        <property type="term" value="C:ATF4-CREB1 transcription factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000791">
        <property type="term" value="C:euchromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035497">
        <property type="term" value="F:cAMP response element binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:RNA polymerase II-specific DNA-binding transcription factor binding"/>
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        <property type="term" value="P:axonogenesis"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0141156">
        <property type="term" value="P:cAMP/PKA signal transduction"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:cellular response to forskolin"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:cellular response to hepatocyte growth factor stimulus"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:cellular response to leukemia inhibitory factor"/>
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        <property type="term" value="P:cellular response to retinoic acid"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:cellular response to zinc ion"/>
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        <property type="entry name" value="Leuzip_CREB"/>
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        <property type="entry name" value="CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN B"/>
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        <property type="entry name" value="Leucine zipper domain"/>
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    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
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    <sequence length="327" mass="35093" checksum="D03FDFB3B049146A" modified="2022-01-19" version="1">MTMESGAENQQSGDAAVTEAETQQMTVQAQPQIATLAQVSMPAAHATSSAPTVTLVQLPNGQTVQVHGVIQAAQPSVIQSPQVQTVQISTIAESEDSQESVDSVTDSQKRREILSRRPSYRKILNDLSSDAPGVPRIEEEKSEEETAAPAIATVTVPTPIYQTSSGQYIAITQGGAIQLSNNGTDGVQGLQTLTMTNAAATQPGTTILQYAQTTDGQQILVPSNQVVVQAASGDVQTYQIRTAPTSTIAPGVVMASSPALPTQPAEEAARKREVRLMKNREAARECRRKKKEYVKCLENRVAVLENQNKTLIEELKALKDLYCHKSD</sequence>
</entry>
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    <accession>A0A8C2TV02</accession>
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        <submittedName>
            <fullName evidence="2">Ring finger protein 115</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="primary">RNF115</name>
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        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
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            <taxon>Theropoda</taxon>
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            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
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        </lineage>
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        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
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                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="Ensembl" id="ENSCJPT00005023865.1">
        <property type="protein sequence ID" value="ENSCJPP00005017076.1"/>
        <property type="gene ID" value="ENSCJPG00005013977.1"/>
    </dbReference>
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        <property type="component" value="Chromosome 25"/>
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        <property type="term" value="C:endoplasmic reticulum"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
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    </dbReference>
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        <property type="term" value="P:negative regulation of toll-like receptor signaling pathway"/>
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        <property type="project" value="Ensembl"/>
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        </source>
    </evidence>
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    <sequence length="368" mass="39098" checksum="F356F778EF39F282" modified="2022-01-19" version="1">MGPCGSMGPCGSMGPCGSMGPCGSMGPCGSMGPCGSLGLCGSIGAEWLYGAVWLYGAVWLYGAVWLYGAAAAPPSQLTLPPQEYTCPRCESGFIEEVTDNSXFLDGGGAEDGPSARFAELWNQLDHTMLFPDFRPFLSSSWDQDGRDTERGHQPHTELWGPGRPPRLPMARRFRSRGSSRPDRSPAIEGIIQQIFAGFFANSAIPGSQHPFSWSGMLHSNPGDYAWGQSGLDAIVTQLLGQLENTGPPPADREKISSLPTVAVTQDQVARHVPGVQEEPERRRLVPSVPRCRWGPSEPGALDVLTPRPIPGPEQPGAASSEPRNLRAPRAAPKPGTVQAEPEPRGVGVCVCVRTGTHSGTTRLGGNEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TV45</accession>
    <name>A0A8C2TV45_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Sidekick cell adhesion molecule 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">SDK1</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Adhesion molecule that promotes lamina-specific synaptic connections in the retina. Expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promotes synaptic connectivity via homophilic interactions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Homodimer; mediates homophilic interactions to promote cell adhesion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Synapse</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the sidekick family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015732346.1">
        <property type="nucleotide sequence ID" value="XM_015876860.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005024393.1">
        <property type="protein sequence ID" value="ENSCJPP00005017511.1"/>
        <property type="gene ID" value="ENSCJPG00005014282.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107320708"/>
    <dbReference type="KEGG" id="cjo:107320708"/>
    <dbReference type="CTD" id="221935"/>
    <dbReference type="GeneTree" id="ENSGT00940000157747"/>
    <dbReference type="OrthoDB" id="8923679at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031430">
        <property type="term" value="C:M band"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048148">
        <property type="term" value="P:behavioral response to cocaine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060998">
        <property type="term" value="P:regulation of dendritic spine development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010842">
        <property type="term" value="P:retina layer formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045214">
        <property type="term" value="P:sarcomere organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007416">
        <property type="term" value="P:synapse assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000202">
        <property type="entry name" value="Sidekick cell adhesion molecule 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000253">
        <property type="entry name" value="Sidekick cell adhesion molecule 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000158">
        <property type="entry name" value="Sidekick cell adhesion molecule 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000177">
        <property type="entry name" value="Sidekick cell adhesion molecule 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000206">
        <property type="entry name" value="Sidekick cell adhesion molecule 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000209">
        <property type="entry name" value="Sidekick cell adhesion molecule 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000231">
        <property type="entry name" value="Sidekick cell adhesion molecule 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000236">
        <property type="entry name" value="Sidekick cell adhesion molecule 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000237">
        <property type="entry name" value="Sidekick cell adhesion molecule 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000261">
        <property type="entry name" value="Sidekick cell adhesion molecule 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000266">
        <property type="entry name" value="Sidekick cell adhesion molecule 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000267">
        <property type="entry name" value="Sidekick cell adhesion molecule 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000271">
        <property type="entry name" value="Sidekick cell adhesion molecule 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000301">
        <property type="entry name" value="Sidekick cell adhesion molecule 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000359">
        <property type="entry name" value="Sidekick cell adhesion molecule 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000360">
        <property type="entry name" value="Sidekick cell adhesion molecule 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000420">
        <property type="entry name" value="Sidekick cell adhesion molecule 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000434">
        <property type="entry name" value="Sidekick cell adhesion molecule 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000485">
        <property type="entry name" value="Sidekick cell adhesion molecule 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050964">
        <property type="entry name" value="Striated_Muscle_Regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817:SF55">
        <property type="entry name" value="PROTEIN SIDEKICK-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817">
        <property type="entry name" value="TITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00014">
        <property type="entry name" value="FNTYPEIII"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="9 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="2066"/>
            <end position="2089"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="19">
        <location>
            <begin position="162"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="19">
        <location>
            <begin position="351"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="19">
        <location>
            <begin position="444"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="19">
        <location>
            <begin position="538"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="19">
        <location>
            <begin position="631"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="20">
        <location>
            <begin position="728"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="20">
        <location>
            <begin position="829"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="20">
        <location>
            <begin position="930"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="20">
        <location>
            <begin position="1032"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="20">
        <location>
            <begin position="1130"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="20">
        <location>
            <begin position="1234"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="20">
        <location>
            <begin position="1337"/>
            <end position="1434"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="20">
        <location>
            <begin position="1438"/>
            <end position="1532"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="20">
        <location>
            <begin position="1537"/>
            <end position="1634"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="20">
        <location>
            <begin position="1639"/>
            <end position="1757"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="20">
        <location>
            <begin position="1762"/>
            <end position="1858"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="20">
        <location>
            <begin position="1859"/>
            <end position="1957"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="20">
        <location>
            <begin position="1960"/>
            <end position="2061"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1529"/>
            <end position="1549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="2134"/>
            <end position="2156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="2251"/>
            <end position="2275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1539"/>
            <end position="1549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="2266"/>
            <end position="2275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00060218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00061621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00065695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005017511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="2275" mass="250939" checksum="00E92721D2FB76AA" modified="2022-01-19" version="1">MCFTFLTGCFGAINTSTRNIDFDGNSNTVRHTECCFRAACKVSTNQRVLGSCEVGLSVPPKLRGKGSWRCSQPTKESLASGCGVSDDQSAARSGRQSDRMGISEAAMVGRKVDREIIARRNSRRDGMMMKLNFCFFFWRRWWAFLLLQLHMLQALAQDDVAPYFKTEPGLPQIHLEGNRLVLTCLAEGSWPLEFKWLHNDSEITTYSSEYKYIIPALQRSDAGFYQCIVRNRMGALLQRRSEVQVAYMGNFMDTNQKKTVPEGEAAVLNFMHIFSYPRPQVTWFRDGHKIIPSSRIAITLENQLVILATSAADAGGYYVQAVNEKNGENKTSPLIHLSIASATNPSDTTAPIIIIPPQNTSVVAGSSEVTLECVANARPVERLSITWKRNGIKITSGISSFGRRLTITNPTSADVGMYFCEAKLRDSTEEPARAKAFISLMEPPYFTAEPESVMLAEVEKDVDILCQAMGVPIPSLVWYKDSVPLSKLQNPRYKVLLSGGLRIHALRPQDAGIFQCFASNKAGEIQTYTYLDVTNIKPAFIQPPEDTTVTEGMTAMLTCEVSGAPKPAISWKKGNQILASGSVQIPRFILLESGGLQITPVFLQDAGNYTCHAVNSEGALNAFVMLTVWNRTFIVHPPENSTVIKGTTATLRCEATHDPRISIRYVWKKDSVVINPSSSSRITVEKDGTLLISQTWSGDIGDYTCEVISFGGNDSRMARLEVIELPHSPQNLLATLNSSYSRSVVLSWVRPFDGNSPVLYYMVELSENNSPWKVHLSNLDPKMTTVTVSGLTPARTYQFRVCAVNQVGRGQYSSETSRLMLPEEPPSAPPKNIVASGRTNQSIMVQWQPPPESEHNGVLHGYILRYRLAGLPGEYQYKNITSAEINYCLVTDLIIWTQYEIQVASYNGAGLGAFSRPVTEYTLQGVPTAPPQNVQVEAVNSTTIQFFWSPPPQQFINGINQGYKLLAWPVDAPGTVTVVTIAPDFHGVHSGCITNLKKYTTYYTSVLCFTTPGDGPRSAPQLLSTLEDKPGAVGHLSFTEILDTSLKVSWQEPVEKNGIITGYQLSWEVYGRNESRLTRTLTNTTLEYKITGLSSLTTYTIEVAAVTAKGTGWVTSSTISSGVPPELPGAPSNLVISNISPRSATLQFRPGYDGKTSICKWIVEGQVGVLGDEEEWVSLHEVDNEPDAQMLEVPNLTPYTHYRFRMRQVNVVGASPLSQPSRVIQTLQAPPDVAPGSVSVRTASESSLRMRWVPLPDTQYNGNPESVGYRIKFWRVDLQPSALLKVINDRLERECTIEDLEEWTEYELQIQAFNAIGAGPWSEVVRGRTRESVPSAPPENVSAEAVSSTQILLTWSAVPESEQNGLILGYKILYKAKDVDSEPRSQTVRGNHTQSCLLSGLRKYVLYEIRVLAFTRIGDGVPSSPAVIERTKDDAPGPPIRLVFPEVRLTSVRIVWQPPEEPNGIILGYQIAYRLASSSPNKFTTVEVGSTVRQFTATDLTPESAYIFRTSAKTRQGWGEPLEATVITTEKRERPAPPQQLTTPQSDVSSRSLQLHWVPGSDGSSPIRYFTVQVRELPNGDWQTYSSSISHEATSCIIESLNPFTSYKLRVKATNDIGDSDFSAETEAVTTLQDVPDEPPGSVLVTPHTTSSVLVQWQPPKAESLNGLLLGYRIYYRELDYDAGSATESKAVKNPSALRAELTPQSSFKTVNSSSALTTYELTQLKKYKRYEVLMTAYNVIGESPTSTPVEVFVGEAAPAMAPQNIQVNSLSASQLELTWDPPPADSQNGNIQGYKIYYWESDVQNDTEKVKVLFLPETTVRLKNLTSHTRYLVCISAFNAAGDGPRSRPSAGRTHQAAPSAPSFLAFSEITSTTLNVSWGEPTAANGVLQGYRVVYEPLAPVQGVSKVVTVDIKGNWQRWLKVRDLTKGMTYLFRVQARTIAYGPELQANVTAGPVEGSPGSPQEILVTKSASGLTVQWTEGDSGEKPTTGYIIEARPSDEGLWDMFVKDIPRSATSYTVSLDKLKQGVTYEFRVVAVNEFGYGEPSVPSVAVSAQTEAPFYEEWWFLLVMALSSVILILLVVFALVLHGQSKKYKNCSAGKTISNVEESVTLDNGGFTALELNSRHLNIKSTFSKKNGTRSPPRPSPGGLHYSDEDICNKYNGAVLTEGLGLNEKPLEMSESEATDSDYEDELPKHSFVNHYMSDPTYYNSWKRQQKGVKHPTSYRYEECSASETEPYFQTVITTQSSGGVYTPTGQPAPGSRTPVTGFSSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U1S6</accession>
    <name>A0A8C2U1S6_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Upstream transcription factor family member 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">USF3</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015729798.1">
        <property type="nucleotide sequence ID" value="XM_015874312.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005029524.1">
        <property type="protein sequence ID" value="ENSCJPP00005021499.1"/>
        <property type="gene ID" value="ENSCJPG00005017202.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107319468"/>
    <dbReference type="KEGG" id="cjo:107319468"/>
    <dbReference type="CTD" id="205717"/>
    <dbReference type="GeneTree" id="ENSGT00390000015759"/>
    <dbReference type="OrthoDB" id="690068at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010719">
        <property type="term" value="P:negative regulation of epithelial to mesenchymal transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd18910">
        <property type="entry name" value="bHLHzip_USF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000051">
        <property type="entry name" value="Basic helix-loop-helix domain-containing protein KIAA2018"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053252">
        <property type="entry name" value="EMT_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048064">
        <property type="entry name" value="USF3_bHLH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46970">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX DOMAIN-CONTAINING PROTEIN USF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46970:SF1">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX DOMAIN-CONTAINING PROTEIN USF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="3">
        <location>
            <begin position="40"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="261"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="785"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="930"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1325"/>
            <end position="1351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1394"/>
            <end position="1422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1537"/>
            <end position="1629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1834"/>
            <end position="1860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1896"/>
            <end position="2025"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="265"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="806"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="958"/>
            <end position="993"/>
        </location>
    </feature>
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        <location>
            <begin position="994"/>
            <end position="1003"/>
        </location>
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            <begin position="1325"/>
            <end position="1340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1341"/>
            <end position="1351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1394"/>
            <end position="1411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1563"/>
            <end position="1572"/>
        </location>
    </feature>
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        <location>
            <begin position="1596"/>
            <end position="1605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1606"/>
            <end position="1618"/>
        </location>
    </feature>
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        <location>
            <begin position="1849"/>
            <end position="1859"/>
        </location>
    </feature>
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        <location>
            <begin position="1896"/>
            <end position="1907"/>
        </location>
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        <location>
            <begin position="1908"/>
            <end position="1927"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1937"/>
            <end position="1947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1967"/>
            <end position="1981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2014"/>
            <end position="2025"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005021499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="2252" mass="240862" checksum="82C2105C09FBEE2C" modified="2022-01-19" version="1">MVPAVGAPPPSPPSPNVLFSETMPEMTENDTPTKKQHRKKNRETHNAVERHRKKKINAGINRIGELIPCSPALKQSKNMILDQAFKYITEMKRQNDELLLNGGNNEQAEEIKKLRKQLDELQKENGRYIELLKANDICLYDDPTIHWKGNLKNAKVSVVIPSDQVQKNIIVYSNGSQPNGNNQGASVQGITFNVGHNLQKQTANVVPVQRTCNLVTPVTISGIYPAENKPRSQSTVSPLAPTQVVPAGNTLELSIPENEQGVHATATSQNTSQSGTEQGLQCSSDNALQNGQSLPKSKNDEGGSKSTKKTVMQGISLPSSACVEAEKVQHMNATSSKTPNSRNEFQESSVISTAGTAVVPSVRLSAADSFSSVNVLKSTNLISSADTPVTSSAEGMKAVTVISTVPASPLENCWSFSGSTGVVPSDLKNMSSLTRMPSAGNTQTTWTTLQLAGNTVQPLSQTPSSIMTALLSEPVNGASTVSAAHSRPLTTSISLNTSLPIDGQAAEQIVVTLPSCPSLPMQPLISQPQVKTQAAGSILPLNSTMQVIQMAQPVASAVTGAPANQNVIILQPPNTAPCPPIVRAEVPSQNVSQQIVIIQAASQNPLPLLSAQPSASVRVPVNGPVAVANSSNSVQNAHLPQTFGGKHLVHILPRPSSLPSSSSTQTFSVTMSNQQHPQTISLNGQLFALQPVMSSSGASNQAPMQIIQPTTSEDPNTNVALNTFGALANLNQSISQMAGQSCLHLSLSHPTNPTTVHNQITTVNCVSLPASVLPSVPLEGSVLTSASNSTNVSPKKAAAGFLSNSKSKRTNKKQSTKKHLAANTEASCPAIPCKDAGKADSVPVEAVAKHSKGEGLPENIPATSQALATLQVSGASISPSKEAECSEQAVGSCPAPETTLAELPAPSPLQPAVSEQLALVPPTARDAAPLLPVRQPQSNPLTSSASSESSSRCEPPGTLTSSQNEAHGTSSQVSGASAVESSTAGQTSTARTTSESCSVPQSSSVVMQDVDLLEGQGLTKMLSDLTKERTVVEKSSSFAVQGEHSNFPMENSKSVESNVDLPEKQELLLMNTEGDALSQHHSCVSDQEVVSAALIASRQADSPMSTSSGSSRGFSVASMLPDTTREDVTSNTSTSTCNNCTFSEQPDIVALAARAIFDQESLEKSGGGMQVNMRDAISKSTDVTLEREQQTFKPLPVKESNAGPLETASNKFSAQDTVQTNVDRQVEKPSCSVGGVETSNSSLQIAASQSPSITSLSVNNLIHQSRIVHPLVSCSSLPQPSEPASIPATVGLSLPSSSYVNPSPRSAMMSEYAQEQLNAIRANSMQAPQLQESRLKQQNQEGRKDSAKRAVQDDLLLSTAKRQKQCQTAPLRLEGMALMNRTPESIADQTQMLVSQMPSNSSNSVASLSSQGHTDGLSRLFPSNSNFITPALRQTEVQCNSQPSISEQQGTAGQHLQPIQHVPAQGISHLHNNHPYLKQQQAGQLRERHHLYQLQHHVTHGENSVHSQPHGVHQQRTIQQEVQMQKKRNLIQGTQAPQLSLQQKHHGSDQTRQKGGQPHPHHQQMQQQMQQHFGASQPEKNCENPTASRNHHNHPQSHINQDMMHQQQQDVSSRQQGSTSEHVSGHNPMQRLMTSRGLEPQMVSQASIVTRPSDMTCTPHRQERNRVSSYSAEALIGKTPSNSEQRIGISLQGPRVSDQLEMRSYIDAARNKGLVIHNMQGRISIDHTVGSDVQRLSDCQTFKPAGPNQQPAGNFDVQASRNSEIGNSVSSLRGMQSQAFRIGQNTGPPIERQKRLPYQPVQGIPTGNSLPSRENENTCHQSFMQSLLAPNLGDQVSGSQRSIPEHPRNTQCGASSTIEYSCPPARESVHIRRDGDGQNRESCDMSISTINTRNSSLTIPFSTSSSSGDIQGRNTSPNISVQKSNPMRMTDSHGTKSHMNTPVSSNMHGVVRPTHPHPAVSHGNGEQGQPSVRQPNSSVTQRSRHPLQDNNSSKIRQPERNRSGNQRHGNVFDPSLPHLPLSTSSSMILGRQQSAIEKRGSIVRFMSDGPQVSNDNAASDQHTLSQNFGFPFIPEGGMNPPINANTSFIPPVTQPSATRTPALIPVDPQNTLPSFYPPYSPAHPTLSNDISIPYFPNQMFPNPTTEKPSSGGLNNRFGSILSPPRPVGFAQPSFPLLPDMPPMHMTNTSHLSNFNLTSLFPEIATALPPDGSAMSPLLSIANTSASDSSKQPSNRPAHNISHILGHDCSSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U1T1</accession>
    <name>A0A8C2U1T1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein jagunal homolog 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">JAGN1</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the jagunal family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2U1T1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005028447.1">
        <property type="protein sequence ID" value="ENSCJPP00005020623.1"/>
        <property type="gene ID" value="ENSCJPG00005016581.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000005596"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050832">
        <property type="term" value="P:defense response to fungus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007029">
        <property type="term" value="P:endoplasmic reticulum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038158">
        <property type="term" value="P:granulocyte colony-stimulating factor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901142">
        <property type="term" value="P:insulin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030073">
        <property type="term" value="P:insulin secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030223">
        <property type="term" value="P:neutrophil differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002446">
        <property type="term" value="P:neutrophil mediated immunity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990266">
        <property type="term" value="P:neutrophil migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009749">
        <property type="term" value="P:response to glucose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009787">
        <property type="entry name" value="Jagunal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20955">
        <property type="entry name" value="PROTEIN JAGUNAL HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20955:SF1">
        <property type="entry name" value="PROTEIN JAGUNAL HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07086">
        <property type="entry name" value="Jagunal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005020623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="175" mass="20119" checksum="7FFC3D8D0F3B774D" modified="2022-01-19" version="1">MASRAGPRAAGTDGSDYRHRERVAPHYQMRWLTYVHVGLWLLLLAQMCVGHLKLLPHDRVAMPYQWQYPYLLSILPSLLGLLSFPRNNISYLVLAMISAGLFSVAPLIYGAMEMFPMAQQLYRHGKAYRFIFGFSAVSVMYLVVVVAAQVHGWQLYYSKKLLDSWFTSTQEKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U230</accession>
    <name>A0A8C2U230_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Calcium/calmodulin-dependent protein kinase type 1G</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">CaM kinase I gamma</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">CaMK-like CREB kinase III</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="primary">CAMK1G</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. In vitro phosphorylates transcription factor CREB1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="22">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015740611.1">
        <property type="nucleotide sequence ID" value="XM_015885125.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U230"/>
    <dbReference type="Ensembl" id="ENSCJPT00005028579.1">
        <property type="protein sequence ID" value="ENSCJPP00005020731.1"/>
        <property type="gene ID" value="ENSCJPG00005016648.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107324780"/>
    <dbReference type="KEGG" id="cjo:107324780"/>
    <dbReference type="CTD" id="57172"/>
    <dbReference type="GeneTree" id="ENSGT00940000156872"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005954">
        <property type="term" value="C:calcium- and calmodulin-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004683">
        <property type="term" value="F:calcium/calmodulin-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14166">
        <property type="entry name" value="STKc_CaMKI_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000026">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000331">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase type 1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="11 21 22" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="15" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 21 22" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0636">Prenylation</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 22" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="24">
        <location>
            <begin position="23"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="328"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="338"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00060242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00071781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00075155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00083144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005020731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="465" mass="51907" checksum="A422EBD46E5CBF68" modified="2022-01-19" version="1">MGRKEEDDSSSWKKQTSNIRKTFIFMEALGSGAFSEVFLVKQRSTGKLFALKCIKKSPLTRDSSLENEIAVLKKIKHENIVTLEDIYESTTHFYLVMQLVSGGELFDRILERGVYTEKDASVVIHQVLTAVKYLHENGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQNGIMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFESPFWDDISDSAKDFIRHLLEKNPDTRFSCEEALRHPWINGNTALHRDIYPSVSAQIQKNFAKSKWRQAFNAAAVVHHMRKLHMNGHAAAGSTHPVIQGSEASRPSTPNAMQPAMPSKDEDISLPQVPCPTPPALLEQSTGMREDKLQNPTVNNGLPDNQSPPARSCGCSPVCTGHERAKASFCSETVLLKKPAKSHHFKSEVLVPMKTGKHSSHCGTGQTGVCLIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U359</accession>
    <name>A0A8C2U359_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Trichohyalin-plectin-homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">CFAP210</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U359"/>
    <dbReference type="Ensembl" id="ENSCJPT00005031023.1">
        <property type="protein sequence ID" value="ENSCJPP00005022636.1"/>
        <property type="gene ID" value="ENSCJPG00005018013.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000167377"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005879">
        <property type="term" value="C:axonemal microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039986">
        <property type="entry name" value="CFAP210"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043597">
        <property type="entry name" value="TPH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28663:SF1">
        <property type="entry name" value="CILIA- AND FLAGELLA- ASSOCIATED PROTEIN 210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28663">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13868">
        <property type="entry name" value="TPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trichohyalin-plectin-homology" evidence="3">
        <location>
            <begin position="145"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="190"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="301"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005022636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="519" mass="61316" checksum="A8CCDDFE11733882" modified="2022-01-19" version="1">HISQSKCRYFHLRSYGQNQKPTETSWLFEENNIPEGCFLPSNVDLRQVVVLPRAEWERMQDSLASVSKEVACILAERKEQQELHLRSKAAVKDWTNTIMAQRKLKARKLREEKQEEERKLIDLEEAKFQAAKWKEAIEKAKTYLYHQNERVKGLHSALLLAEVLKERDAQIEFKKLKSDGSKKIEEEMERRRKEAILREEEKVKQRLMNRLALSRDQLQQIEEHKRQAELAKLEDKREGEEVQRQIQLYQLELLRKMEKEQEKRAENQRLYNVNDQKIIKAVEEQKQMEEDDRIRAHYKGKQTIAKLMKEKEAEMRRIKQERQDKIVSQLAAQMNVALKMEDERLARDIARKEAAYEKEQKEKEAKKKAAIESIAEYRATVVRKLTCSHPCLWRTFLPQAEKKAKIQQEKQADLDYDIETELIALHREQEFQKYAKQVIESESKTTHHLYPLLKASKEIIGFGGSPFSIESEGTNPGFQAQDAAETQLPCCRASCTKWKFREEKKRNGRRNLNTRGSIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U3I5</accession>
    <name>A0A8C2U3I5_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="19 21">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="5 21">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">UCHL1</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Ubiquitin-protein hydrolase is involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 20 21">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 20 21">Belongs to the peptidase C12 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="5 21"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2U3I5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005029388.1">
        <property type="protein sequence ID" value="ENSCJPP00005021401.1"/>
        <property type="gene ID" value="ENSCJPG00005017116.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157306"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904115">
        <property type="term" value="C:axon cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044306">
        <property type="term" value="C:neuron projection terminus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031694">
        <property type="term" value="F:alpha-2A adrenergic receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008242">
        <property type="term" value="F:omega peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030547">
        <property type="term" value="F:signaling receptor inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007628">
        <property type="term" value="P:adult walking behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007412">
        <property type="term" value="P:axon target recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019896">
        <property type="term" value="P:axonal transport of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042755">
        <property type="term" value="P:eating behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002176">
        <property type="term" value="P:male germ cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055001">
        <property type="term" value="P:muscle cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050905">
        <property type="term" value="P:neuromuscular process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045821">
        <property type="term" value="P:positive regulation of glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002931">
        <property type="term" value="P:response to ischemia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09616">
        <property type="entry name" value="Peptidase_C12_UCH_L1_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.532.10:FF:000006">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057254">
        <property type="entry name" value="UCH_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF19">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE ISOZYME L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00707">
        <property type="entry name" value="UBCTHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00140">
        <property type="entry name" value="UCH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 20 21" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-0636">Prenylation</keyword>
    <keyword evidence="8 20 21" id="KW-0645">Protease</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 20 21" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="9 20 21" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="23">
        <location>
            <begin position="44"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="11"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="20">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="20">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="20">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="20">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00055560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00073226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU361215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005021401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="270" mass="29086" checksum="5995701AC02B24CC" modified="2022-01-19" version="1">VPVSARPFLLSPPSKLPDGGSRTCGAARGRAGGDGGSALCCVTGARPGGVGSGPDTRCAPQVLSRLGVSPGWRFVDVLGFEEEALGAVPSPACALLLLFPLTEQHENFRKQQTEKIKDQEISSKVYFLKQTVSNSCGTIGLIHAVANNKDKVKLDEGSALKKFLDETADLSPEERAKRFANNKAIQEVHNSVAQEGQCRVEDNSVNFHFILFANVDGHLYELDGRLPFPVNHGTSSDDLLLKDSAKICRQFTEREKGEVRFSAVAFCKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U514</accession>
    <name>A0A8C2U514_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NEDD4 binding protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">N4BP2</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="Ensembl" id="ENSCJPT00005029446.1">
        <property type="protein sequence ID" value="ENSCJPP00005021450.1"/>
        <property type="gene ID" value="ENSCJPG00005017131.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160604"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046404">
        <property type="term" value="F:ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004520">
        <property type="term" value="F:DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14365">
        <property type="entry name" value="CUE_N4BP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013899">
        <property type="entry name" value="DUF1771"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056718">
        <property type="entry name" value="DUF7816"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056719">
        <property type="entry name" value="DUF7817"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056720">
        <property type="entry name" value="DUF7818"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052772">
        <property type="entry name" value="Endo/PolyKinase_Domain-Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041801">
        <property type="entry name" value="N4BP2_CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46535">
        <property type="entry name" value="NEDD4-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46535:SF1">
        <property type="entry name" value="NEDD4-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13671">
        <property type="entry name" value="AAA_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08590">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25124">
        <property type="entry name" value="DUF7816"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25125">
        <property type="entry name" value="DUF7817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25126">
        <property type="entry name" value="DUF7818"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01713">
        <property type="entry name" value="Smr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01162">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SMR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUE" evidence="3">
        <location>
            <begin position="38"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Smr" evidence="2">
        <location>
            <begin position="1640"/>
            <end position="1719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="619"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="684"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="737"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="782"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="856"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1144"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1185"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1254"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1297"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="629"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="653"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="684"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="792"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="879"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1155"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1185"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1265"/>
            <end position="1276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005021450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1719" mass="192702" checksum="A95A2A79592CAEE6" modified="2022-01-19" version="1">MPRRRKIGGSPSRKTIAAAVVPLGNPSLSVSQATYRVNKEELFNSMSEMFSDLDPSVVYMVLSECDFKVENAMDYLLELSTHAEGAASSKVSDFESVASSLALVNQRRSVPDQRMWESIVKRCNSEEEKEKVLSPDAPLTEELDSLIESAFQRCSLSDELPNSANDQIVCEHDGFKEFPEWEESDLGRDVLLFPQQIETDNEVLENCYSQLPVGQLNIQTPAEHPTSPAASDPFAQALGDSDLSKIHVHHDIASAAFKQSSGETSCGNSDQAQHTVSDNKSLTTTSEPNSQCLQQHGELMNACYSHNASLPEAYASLEKSSLETPKLKDFQQSEQDYSLNISTLSRRTQQHWNPMAPVFYPSSESHSFVTPVAASPGQWRPVSDCRTLEKGLAFSSPVVPNAWDSSPSLKVWENQDRNSKLNLSQAQQPPVCHMMRKKMHLIGQVLVLLRGVPGSGKSYLARMILEDNPGGVILSTDDYFYRGGKYHYDAYCLGEAHDWNRKRAKEAFEMKISPIIIDNTNIQAWEMKPYVTLAQQFKYKVIFREPDTWWKFKPKELERRNIHGVPKEKIKRMLEQYERCLTVNSILASSVPEKSEVTAWNEDPCQEGSHRLDSFTRFADNLPEDDKPLSSSSLTSESNCAPESYRKEETEMENNSVEHSTEKNTVQGDLDVDLPSCVEEELPLEEKGEKGERMEEMTETEMDETDMIKTEETVCLHRGVEKHSNNNILTVQTGTEQNSEIGMESDSAERSKVVEPSSSAMEASGKPELLNFLGDWPVQQTMGQRVKRNRRLEKSSLKSDKEDKTPGQHPELGKEHAGLPDTCTVVKGQEEENTTSSCFSVSSDKVAPDLQMAGQWPVSLEQRQQRSRRMRKTSLSQTDEGRNTEGDVNRSALDTVDVLRGTPVDTVEQDVNELHFHQPEMVGSETIAKKKTQQNKRTKKHHKLALTFTNNNLPHSKEEEQLSVPNSVEEKQDACSCKQISSHSQTESHDFALLWRLENKMLFPETVKVLHGRLDGFKPKDINNASGSQEKIPYRVTYDKSTFVEESELIDIDETEKLNMLCKLFDSFSFEAVKDLYERCNKDINWATGLLLDSDEKLHEDVSTEWFEVKEAEPVVADFDFKENINYDENLENCTHTEQITGATNVFDPSEDKNSSLSTEESTATKTVVTDAGVSDSFTAVLSNDSVELKSSSDTAPEGYAGSSATGVHEQCISGMQKMESVSPVEEVMNKLSVSQADVDLSVPVTLSHALKTTSNSKLSDESDSNSSESNAENAKGMPLLLEMDNVPLIDSRNDKELESDRENLGSSGEISGKEGSGILSRNEDKAKIQSPSPVSSAAFDINSLELTLPPELALQLKEIFGPVGIDAGSLTAEDCVVHIDMNLAKVIHEKWKESILVDSKTQKKGTIWVSSSSNEMQTKKAATSEVFPFMDHWNARTQKVSLRQIISEEIAMQEREDLKRVPSMARKDCAAKLKEKQLFEMFPTINQNFLMDIFKDNNYSLEQTEQFLNCVLEADPVKTVIAQESVQRNEIASSYSAAKNREKVARKAKEEDDVLSEIFQDYEYPQYDDFRAEAFHHQQKRKECLKKAGEAYHMGMKPVAAFYAHQGRLHEQKMKEANHAAAARIFESVNTSLLPLNVLDLHGLHVDEAVNQLSRVLQEKSNEYQQSGGKPYLCVITGRGSHSQGGVARIKPAAIRYLNSHNFRFAEIKPGCLKVMLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U607</accession>
    <name>A0A8C2U607_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="2">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">UBE2L3</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="2"/>
    <dbReference type="RefSeq" id="XP_015733040.1">
        <property type="nucleotide sequence ID" value="XM_015877554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U607"/>
    <dbReference type="SMR" id="A0A8C2U607"/>
    <dbReference type="Ensembl" id="ENSCJPT00005032852.1">
        <property type="protein sequence ID" value="ENSCJPP00005024059.1"/>
        <property type="gene ID" value="ENSCJPG00005019011.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107321050"/>
    <dbReference type="KEGG" id="cjo:107321050"/>
    <dbReference type="CTD" id="7332"/>
    <dbReference type="GeneTree" id="ENSGT00940000153654"/>
    <dbReference type="OrthoDB" id="9973183at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd23801">
        <property type="entry name" value="UBCc_UBE2L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000011">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="7">
        <location>
            <begin position="2"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="5">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005024059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="154" mass="17862" checksum="F5A30243BE3C9985" modified="2022-01-19" version="1">MAASRRLMKELEEIRKCGMKNFRNIQVDEANLLTWQGLIVPDNPPYDKGAFRIEINFPAEYPFKPPKITFKTKIYHPNIDEKGQVCLPVISAENWKPATKTDQVIQSLIALVNDPQPEHPLRADLAEEYSKDRKKFCKNAEEFTKKYGEKRPVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U7N1</accession>
    <name>A0A8C2U7N1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Superoxide dismutase [Cu-Zn]</fullName>
            <ecNumber evidence="15">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">SOD3</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="function">
        <text evidence="14">Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="15">Binds 1 copper ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the Cu-Zn superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="15"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2U7N1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005031705.1">
        <property type="protein sequence ID" value="ENSCJPP00005023129.1"/>
        <property type="gene ID" value="ENSCJPG00005018375.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162224"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001666">
        <property type="term" value="P:response to hypoxia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00305">
        <property type="entry name" value="Cu-Zn_Superoxide_Dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.200:FF:000008">
        <property type="entry name" value="Superoxide dismutase [Cu-Zn]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024134">
        <property type="entry name" value="SOD_Cu/Zn_/chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018152">
        <property type="entry name" value="SOD_Cu/Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10003">
        <property type="entry name" value="SUPEROXIDE DISMUTASE CU-ZN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00068">
        <property type="entry name" value="CUZNDISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00087">
        <property type="entry name" value="SOD_CU_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00332">
        <property type="entry name" value="SOD_CU_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="10 15" id="KW-0186">Copper</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 16" id="KW-0732">Signal</keyword>
    <keyword evidence="7 15" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034548273" description="Superoxide dismutase [Cu-Zn]" evidence="16">
        <location>
            <begin position="19"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Superoxide dismutase copper/zinc binding" evidence="17">
        <location>
            <begin position="76"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00060347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005023129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="236" mass="26026" checksum="41DF1FA5BE42644B" modified="2022-01-19" version="1">MLLLLSLLTGLALSGVVTETGTDPSHASLHDIQRKVNDLWQSLLYPVMADNESDGLTYATCEMKPSSKIDADKPQVTGQVLFRQHYSQGRLEAIFHLDGFPLDNNQSGRAIHIHELGDLSNGCDSTGGHYNPFRVNHPRHPGDFGNFSPKEGKIQKYKPNLFATMFGPYSILGRSIVVHEQEDDMGKGNNKASLENGNAGKRLACCVIGICNKNLWEEKQSEAIDKRSQAVASEYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U7U9</accession>
    <name>A0A8C2U7U9_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NIPA magnesium transporter 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">NIPA2</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NIPA family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015706657.1">
        <property type="nucleotide sequence ID" value="XM_015851171.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U7U9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005033579.1">
        <property type="protein sequence ID" value="ENSCJPP00005024672.1"/>
        <property type="gene ID" value="ENSCJPG00005019415.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107307643"/>
    <dbReference type="KEGG" id="cjo:107307643"/>
    <dbReference type="CTD" id="81614"/>
    <dbReference type="GeneTree" id="ENSGT00940000155651"/>
    <dbReference type="OrthoDB" id="6428174at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF1">
        <property type="entry name" value="MAGNESIUM TRANSPORTER NIPA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005024672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="361" mass="39063" checksum="4331825BB38544CC" modified="2022-01-19" version="1">MSQARGRYDFCIGLVLAMSSSIFIGGSFILKKKGLLRLARKGSMRAGQGGHAYLKEWLWWAGLLSMGVGEAANFAAYAFAPATLVTPLGALSVLVSAILSSFFLNEKLNLHGKIGCLLSILGSTVMVIHAPQEEEVETLDEMSNKLRDPGFVVFATLVVIVSLILIVVVGPRHGQTNILVYITICSVIGALSVSCVKGLGIAIKELFAGKPVLKSPLSWILLLSLIVCVSTQINYLNRALDIFNTSIVTPIYYVIFTTSVLTCSAILFKEWQHMAADDIIGTFSGFLTIIVGIFLLHAFKDVNFTLANLPVSLRKDDRAANGSLLSTYDCFNHDEESTPCLSEIQSTESLSARRNGSLSAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U809</accession>
    <name>A0A8C2U809_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rho GTPase-activating protein 19</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Rho-type GTPase-activating protein 19</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ARHGAP19</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2U809"/>
    <dbReference type="Ensembl" id="ENSCJPT00005033950.1">
        <property type="protein sequence ID" value="ENSCJPP00005024923.1"/>
        <property type="gene ID" value="ENSCJPG00005019619.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157331"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04392">
        <property type="entry name" value="RhoGAP_ARHGAP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000022">
        <property type="entry name" value="rho GTPase-activating protein 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047941">
        <property type="entry name" value="ARHGAP19_RhoGAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14963">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN 18,19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14963:SF7">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="6">
        <location>
            <begin position="67"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="296"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="319"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00055252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00070235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00083391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005024923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="509" mass="57462" checksum="468ED7E4DC018DDE" modified="2022-01-19" version="1">QPIIFNPDFFVEKLRHEKPEVFTELVVSNITRLIDLPGAELAQLMGEEDPKLPGANSTASGFFRSLMSLKRKEKGVVFGSPLTEEGIAQVSQLIEYLHKNLRAEGLFRVPGNSIRQQILKDALNSGTDIDLDSGEFHSNDVATLLKMFLGELPEPLLTHKHFHAHLKIADLMLFDEKGNKTSTPDKERQIEALQLLFLILPAPNRSLLKLLLDLLYQTAKKQDKNKMSAHNLALMFAPHILWPRNVTANDLQENITKLNNGVTFMIKHSQKLFKAPVYIRECARLHYLGSRAHTSKDDLDLLTSPGSKELQPLKSQKRSRLDSCHQEETQQRTEEALRELFRHVHNMPDSAKKKKLIRQFNKHPSALTPSSDVATPPATRRTRSRSFSGLIKRKVLGTPVIQERKSRDTTPEPKRVSKENVHLLQKCGSPAHTSQGKLKSLEGQKEVRNTNVHVLTVRTWPTELSPEGQRDLQRCCHTHEALPLAVAAMVLWLHQSAPCQADGMLGTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U849</accession>
    <name>A0A8C2U849_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ketimine reductase mu-crystallin</fullName>
            <ecNumber evidence="16">1.5.1.1</ecNumber>
            <ecNumber evidence="2">1.5.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">NADP-regulated thyroid-hormone-binding protein</fullName>
        </alternativeName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(3R)-1,4-thiomorpholine-3-carboxylate + NAD(+) = 3,4-dehydrothiomorpholine-3-carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12504"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58517"/>
            <dbReference type="ChEBI" id="CHEBI:176873"/>
            <dbReference type="EC" id="1.5.1.25"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="8">
            <dbReference type="Rhea" id="RHEA:12506"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(3R)-1,4-thiomorpholine-3-carboxylate + NADP(+) = 3,4-dehydrothiomorpholine-3-carboxylate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12500"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58517"/>
            <dbReference type="ChEBI" id="CHEBI:176873"/>
            <dbReference type="EC" id="1.5.1.25"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:12502"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(R)-lanthionine ketimine + NADPH + 2 H(+) = (3R,5R)-1,4-thiomorpholine-3,5-dicarboxylate + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:68040"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:176891"/>
            <dbReference type="ChEBI" id="CHEBI:176892"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:68041"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(S)-cystathionine ketimine + NADH + 2 H(+) = (3R,5S)-2,3,5,6,7-pentahydro-1,4-thiazepine-3,5-dicarboxylate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:68032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:176808"/>
            <dbReference type="ChEBI" id="CHEBI:176810"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:68033"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(S)-cystathionine ketimine + NADPH + 2 H(+) = (3R,5S)-2,3,5,6,7-pentahydro-1,4-thiazepine-3,5-dicarboxylate + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:68036"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:176808"/>
            <dbReference type="ChEBI" id="CHEBI:176810"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:68037"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Delta(2)-thiazoline-2-carboxylate + NADPH + 2 H(+) = L-thiazolidine-2-carboxylate + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:68072"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:176895"/>
            <dbReference type="ChEBI" id="CHEBI:176896"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:68073"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-pipecolate + NAD(+) = Delta(1)-piperideine-2-carboxylate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:30807"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:61185"/>
            <dbReference type="ChEBI" id="CHEBI:77631"/>
            <dbReference type="EC" id="1.5.1.1"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="5">
            <dbReference type="Rhea" id="RHEA:30809"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-pipecolate + NADP(+) = Delta(1)-piperideine-2-carboxylate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12524"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61185"/>
            <dbReference type="ChEBI" id="CHEBI:77631"/>
            <dbReference type="EC" id="1.5.1.1"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="14">
            <dbReference type="Rhea" id="RHEA:12526"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-proline + NAD(+) = 1-pyrroline-2-carboxylate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20321"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:39785"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.1"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="13">
            <dbReference type="Rhea" id="RHEA:20323"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-proline + NADP(+) = 1-pyrroline-2-carboxylate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20317"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:39785"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.1"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="7">
            <dbReference type="Rhea" id="RHEA:20319"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homodimer. Binds the thyroid hormone triiodothyronine (T3); T3 binding inhibits enzymatic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ornithine cyclodeaminase/mu-crystallin family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.1" evidence="16"/>
    <dbReference type="EC" id="1.5.1.25" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2U849"/>
    <dbReference type="Ensembl" id="ENSCJPT00005032518.1">
        <property type="protein sequence ID" value="ENSCJPP00005023785.1"/>
        <property type="gene ID" value="ENSCJPG00005018801.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050241">
        <property type="term" value="F:pyrroline-2-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047127">
        <property type="term" value="F:thiomorpholine-carboxylate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070324">
        <property type="term" value="F:thyroid hormone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042403">
        <property type="term" value="P:thyroid hormone metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1780.10">
        <property type="entry name" value="ornithine cyclodeaminase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003462">
        <property type="entry name" value="ODC_Mu_crystall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023401">
        <property type="entry name" value="ODC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812">
        <property type="entry name" value="KETIMINE REDUCTASE MU-CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812:SF19">
        <property type="entry name" value="KETIMINE REDUCTASE MU-CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02423">
        <property type="entry name" value="OCD_Mu_crystall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00093190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00093197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00093203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00093226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00093227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00093248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00093250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00093263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00093273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00093567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00093598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00093650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005023785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="142" mass="14612" checksum="C2AF29FF3D8FA369" modified="2022-01-19" version="1">SSRVPLRAPRVHQRCRRGAACCPAPAVTAGTRGPLQNFSAGPERGNGGGSARPFCAIHPVLVPSFLGVMPAYSAADDALSTKLVTFYEPRGDSAAPSHQATVLLFDPRLRGAVLDGAVITAKRTAAVSAIATKVSAPPSPQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U867</accession>
    <name>A0A8C2U867_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Sp5 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">SP5</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the Sp1 C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015724030.1">
        <property type="nucleotide sequence ID" value="XM_015868544.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U867"/>
    <dbReference type="Ensembl" id="ENSCJPT00005031192.1">
        <property type="protein sequence ID" value="ENSCJPP00005022746.1"/>
        <property type="gene ID" value="ENSCJPG00005018086.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107316726"/>
    <dbReference type="KEGG" id="cjo:107316726"/>
    <dbReference type="CTD" id="389058"/>
    <dbReference type="GeneTree" id="ENSGT00940000160673"/>
    <dbReference type="OrthoDB" id="6365676at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060349">
        <property type="term" value="P:bone morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036342">
        <property type="term" value="P:post-anal tail morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd22541">
        <property type="entry name" value="SP5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000014">
        <property type="entry name" value="Transcription factor Sp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000026">
        <property type="entry name" value="Transcription factor Sp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000061">
        <property type="entry name" value="Transcription factor Sp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF29">
        <property type="entry name" value="TRANSCRIPTION FACTOR SP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="266"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="296"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="326"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="77"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005022746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="368" mass="39653" checksum="AA749F66AF3D0144" modified="2022-01-19" version="1">MAAVAVLRNDSLQAFLQDRTPSASPDVAKHSPLALLAATCSRIGQPGAAPADFLPVPYEPTLGSPSRIFHPWGGEMPAHSPGGLPPPHPSLGLTPQKSHLQPSFGGGHELPLTPPADPSYPYEFSPVKMLPSSMAALPSACPPAYVPYAAQAALPPGYSNLLPPAQPCRQLSPNPPPEDLPWWSIPQAAAPPGCAHRFPAAAAALPRGLVLGHSDFAQYQTQIAALLQTKSPLAATARRCRRCRCPNCQAAAGSAPEAEPGKKKQHICHIPGCGKVYGKTSHLRAHLRWHTGERPFVCNWLFCGKSFTRSDELQRHLRTHTGEKRFVCPECGKRFMRSDHLAKHVKTHQNKKLKAAADAVKREDGRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U8S8</accession>
    <name>A0A8C2U8S8_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Proteasome 26S subunit, non-ATPase 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">PSMD11</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S9 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2U8S8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005033033.1">
        <property type="protein sequence ID" value="ENSCJPP00005024208.1"/>
        <property type="gene ID" value="ENSCJPG00005019081.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063301"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005838">
        <property type="term" value="C:proteasome regulatory particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048863">
        <property type="term" value="P:stem cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000003">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050871">
        <property type="entry name" value="26S_Proteasome/COP9_Components"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040780">
        <property type="entry name" value="Rpn6_C_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040773">
        <property type="entry name" value="Rpn6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10678">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18503">
        <property type="entry name" value="RPN6_C_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18055">
        <property type="entry name" value="RPN6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="267"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005024208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="465" mass="52020" checksum="0C9B68C6EDBA9718" modified="2022-01-19" version="1">MWDMGEGTEDVWCGMEGLGFTLWVRGLGGTSAAGRAQQRSAVKMAAAAVLEFQRAQSLLSTDREASIGILHSIVKRDVQENDEEAVQVKEQSILELGSLLAKTGQAEELGGLLKYVRPFLNSISKAKAARLVRSLLDLFLDMEAATGQEVDLCLECIEWAKSEKRTFLRQALEARLVSLYFDTRRYQEALQLGSQLLRELKKMDDKALLVEVQLLESKTYHALSNLPKARAALTSARTTANAIYCPPKLQAALDMQSGIIHAAEEKDWKTAYSYFYEAFEGYDSIDNPKAITALKYMLLCKIMLNAPEDVQALVSGKLALRYAGRQTEALKCVAQASKNRSLADFEKALTDYKVELRDDPIINTHLAKLYDNLLEQNLIRVIEPFSRVQMEHISGLIKLSKADVERKLSQMILDKKFHGILDQGEGVLIIFDEPPVDKTYEAALETIQNMSKVVDSLYNKAKKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UAR4</accession>
    <name>A0A8C2UAR4_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Acid-sensing ion channel 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2UAR4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005033073.1">
        <property type="protein sequence ID" value="ENSCJPP00005024238.1"/>
        <property type="gene ID" value="ENSCJPG00005019138.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154991"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3590.10:FF:000001">
        <property type="entry name" value="acid-sensing ion channel 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.770:FF:000006">
        <property type="entry name" value="acid-sensing ion channel 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3590.10">
        <property type="entry name" value="acid-sensing ion channel 1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF128">
        <property type="entry name" value="ACID-SENSING ION CHANNEL 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="3 11" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="9 11" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="224"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005024238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="258" mass="28396" checksum="BA3FD5A5A223EF22" modified="2022-01-19" version="1">MDLKDSTSEGSMGSLQPSSIQIFANTSTLHGIRHVFVYGPVTIRRLLWTLAFVGSLGLLLVESSDRVAFYFSYPHVTKLDEVAATRLTFPAVTFCNLNEFRFSRLTTNDLYHAGELLALLDVNLQIPNPHLADPAVLAILQEKANFKQYKPKVFNMQEFLARVGHDLKDMMLYCKFKGQECNHEDFKTVSMSRCSAFFHSGHVDGGGAGPGQPWMSLAVLRGHSRAGQPEDHAGTDAAQLTAPGCHPIGSSAGRQRQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UAW0</accession>
    <name>A0A8C2UAW0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Endonuclease</fullName>
            <ecNumber evidence="14">3.1.30.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">ENDOG</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the DNA/RNA non-specific endonuclease family.</text>
    </comment>
    <dbReference type="EC" id="3.1.30.-" evidence="14"/>
    <dbReference type="RefSeq" id="XP_015734413.1">
        <property type="nucleotide sequence ID" value="XM_015878927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UAW0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005035271.1">
        <property type="protein sequence ID" value="ENSCJPP00005025994.1"/>
        <property type="gene ID" value="ENSCJPG00005020305.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107321732"/>
    <dbReference type="KEGG" id="cjo:107321732"/>
    <dbReference type="CTD" id="2021"/>
    <dbReference type="GeneTree" id="ENSGT00940000160987"/>
    <dbReference type="OrthoDB" id="5418055at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006309">
        <property type="term" value="P:apoptotic DNA fragmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032043">
        <property type="term" value="P:mitochondrial DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032007">
        <property type="term" value="P:negative regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090297">
        <property type="term" value="P:positive regulation of mitochondrial DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034612">
        <property type="term" value="P:response to tumor necrosis factor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00091">
        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.570.10:FF:000002">
        <property type="entry name" value="Endonuclease G, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.570.10">
        <property type="entry name" value="Extracellular Endonuclease, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018524">
        <property type="entry name" value="DNA/RNA_endonuclease_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044929">
        <property type="entry name" value="DNA/RNA_non-sp_Endonuclease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001604">
        <property type="entry name" value="Endo_G_ENPP1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020821">
        <property type="entry name" value="ENPP1-3/EXOG-like_nuc-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040255">
        <property type="entry name" value="Non-specific_endonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966:SF5">
        <property type="entry name" value="ENDONUCLEASE G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966">
        <property type="entry name" value="ENDONUCLEASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01223">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00892">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00477">
        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01070">
        <property type="entry name" value="NUCLEASE_NON_SPEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 14" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 14" id="KW-0540">Nuclease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034084612" description="Endonuclease" evidence="15">
        <location>
            <begin position="23"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="DNA/RNA non-specific endonuclease/pyrophosphatase/phosphodiesterase" evidence="17">
        <location>
            <begin position="79"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="ENPP1-3/EXOG-like endonuclease/phosphodiesterase" evidence="16">
        <location>
            <begin position="80"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR640255-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR640255-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU366055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005025994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="300" mass="33343" checksum="507EB490BB5388DC" modified="2022-01-19" version="1">MLWGRWLLPGASLAVGAGLGAALSARWQRGAADTEVPGLLCRLPVVPVVSADSSAPAPIEPARTELTKYGLPGLAQLRSRESYVLCYDPRSRSALWVIEQLNKETLSGTSDRSSCDFQEDDSVHEYHRATNADYRGSGFDRGHLAAAANHKWSQKAMRDTFYLSNVAPQVPHLNQNAWNNLEKYSRSLARNNKNVYVCTGPLYLPRMEADGKMYVKYQVIGKNNVAVPTHFFKVLILEKESGEIELRSYVMPNSPVDEKIPLERFLVPIESIERASGLLFVPNILKRTSSLKAITAGNKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UAX8</accession>
    <name>A0A8C2UAX8_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ZDHHC22</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="RefSeq" id="XP_015720687.1">
        <property type="nucleotide sequence ID" value="XM_015865201.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UAX8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005033352.1">
        <property type="protein sequence ID" value="ENSCJPP00005024475.1"/>
        <property type="gene ID" value="ENSCJPG00005019279.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107315145"/>
    <dbReference type="KEGG" id="cjo:107315145"/>
    <dbReference type="CTD" id="283576"/>
    <dbReference type="GeneTree" id="ENSGT00730000111268"/>
    <dbReference type="OrthoDB" id="302728at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="8">
        <location>
            <begin position="104"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005024475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="275" mass="30658" checksum="8F169347D5BDC787" modified="2022-01-19" version="1">MLVLRLLNVVAPAYFLCISLVTFVLQIFLFIPSMFRDPSTTSLFSPALLHGALFLFLSANALGNYILVIQSSPEELGKGLNLGEGAEMVADWLDGSRSPGSALPSTHYCRLCARVTQRHDHHCFFTGNCIGSRNMRNFIMFCLYTSLACLDSLVAGMAYISASLSMSFANPLAFLTLLPHSISQFFSGALLSSEMFVILMLYLWLGIGLACAGFCCHQMLLILRGQTRYQVRKGIVVRARPWRENLREVFGKRWLLGLLIPMLNVGSDCRRQKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UDX1</accession>
    <name>A0A8C2UDX1_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Protein inhibitor of activated STAT 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">PIAS1</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIAS family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2UDX1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005036608.1">
        <property type="protein sequence ID" value="ENSCJPP00005027032.1"/>
        <property type="gene ID" value="ENSCJPG00005020993.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234539"/>
    <dbReference type="UniPathway" id="UPA00886"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016605">
        <property type="term" value="C:PML body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099524">
        <property type="term" value="C:postsynaptic cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099523">
        <property type="term" value="C:presynaptic cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140297">
        <property type="term" value="F:DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061665">
        <property type="term" value="F:SUMO ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000729">
        <property type="term" value="P:DNA double-strand break processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045444">
        <property type="term" value="P:fat cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032436">
        <property type="term" value="P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904377">
        <property type="term" value="P:positive regulation of protein localization to cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033235">
        <property type="term" value="P:positive regulation of protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042127">
        <property type="term" value="P:regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd16818">
        <property type="entry name" value="SP-RING_PIAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.720.30:FF:000001">
        <property type="entry name" value="E3 SUMO-protein ligase PIAS2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.780:FF:000001">
        <property type="entry name" value="E3 SUMO-protein ligase PIAS2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000003">
        <property type="entry name" value="E3 SUMO-protein ligase PIAS2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.780">
        <property type="entry name" value="PINIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023321">
        <property type="entry name" value="PINIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038654">
        <property type="entry name" value="PINIT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782:SF11">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE PIAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782">
        <property type="entry name" value="ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14324">
        <property type="entry name" value="PINIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02891">
        <property type="entry name" value="zf-MIZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51466">
        <property type="entry name" value="PINIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51044">
        <property type="entry name" value="ZF_SP_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SAP" evidence="16">
        <location>
            <begin position="7"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="PINIT" evidence="18">
        <location>
            <begin position="120"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="SP-RING-type" evidence="17">
        <location>
            <begin position="316"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="460"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="587"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="477"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="593"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005027032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="639" mass="70284" checksum="66B8440B20A1E06B" modified="2022-01-19" version="1">RADTQMVMSLRVSELQVLLGYAGRNKHGRKHELLTKALHLLKAGCSPAVQMKIKELYRRRFPQKIMTPADLSLSSVHSSSMPATLSPSTIPQLSYDGHPATSPLLPVSLLGPKHELELPHLTSALHPVHPDIKLQKLPFYDLLDELIKPTSLASDNSQRFRETCFAFALTPQQVQQISSSMDISGTKCDFTVQVQLRFCLSETSCPQEDHFPPNLCVKVNGKPCSLPGYLPPTKNGVEPKRPSRPINITSLVRLSTTVPNTIVVSWTAEIGRNYSMAVYLVKQLSSTVLLQRLRAKGIRNPDHSRALIKEKLTADPDSEIATTSLRVSLLCPLGKMRLTIPCRALTCSHLQCFDATLYIQMNEKKPTWVCPVCDKKAPYEHLIIDGLFMEILKYCTDCDEIQFKEDGSWAPMRSKKEVQEVTTSYNGVDGCISSSLEHQVSSHQQSNKNKKVEVIDLTIDSSSDEEEEEPSAKRSCPSISPASPMNNKGILNLPHQASPVSRTPSLPAVDTSYINTSLIQDYRHPFHMTPMPYDLQGKLLAHYNTSLLAAAAAAVSASDDQELLHSRFFPYTSSQMFLDQLNAGGSSSLPATNGSNSGSNSSLVSSNSLRENHGHPVASRSGADTASIFGIISDIISLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UGJ9</accession>
    <name>A0A8C2UGJ9_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Rab GTPase-activating protein 1-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">RABGAP1L</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">GTP-hydrolysis activating protein (GAP) for small GTPase RAB22A, converting active RAB22A-GTP to the inactive form RAB22A-GDP. Plays a role in endocytosis and intracellular protein transport. Recruited by ANK2 to phosphatidylinositol 3-phosphate (PI3P)-positive early endosomes, where it inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Early endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2UGJ9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005037189.1">
        <property type="protein sequence ID" value="ENSCJPP00005027519.1"/>
        <property type="gene ID" value="ENSCJPG00005021336.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154611"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01211">
        <property type="entry name" value="PTB_Rab6GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.750:FF:000004">
        <property type="entry name" value="Putative rab gtpase-activating protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000007">
        <property type="entry name" value="Rab GTPase-activating protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000202">
        <property type="entry name" value="rab GTPase-activating protein 1-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000001">
        <property type="entry name" value="TBC1 domain family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022164">
        <property type="entry name" value="Kinesin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF7">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12473">
        <property type="entry name" value="DUF3694"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PID" evidence="13">
        <location>
            <begin position="72"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Rab-GAP TBC" evidence="14">
        <location>
            <begin position="517"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="440"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="758"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="941"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="461"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00059592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005027519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1018" mass="116950" checksum="4E5C9ED141534FED" modified="2022-01-19" version="1">MEVRTSYSEASRIPETVSTLINEEFVVVHQQTEDLSGKDAKPQLKVYLSARRSSSPSEPLEEDSVLFNKLTYMGCMKVSAPRNEPEALRAMANLKSSSQAPLSVTLYVPNVPEGSVRIIDQSSNVEIASFPIYKVLFCVRGQNGTAESDCFAFTESSCGTEEFQIHVFSCEIKEAVSRILYSFSTAFKRSSKQVSDHVKDFVLPTPDSDVYTFSVSLEVKEDDGKGNFSPVPKDRDKLYFKLKQGIEKKVVITVQQLSNKELAIERCFGMLLSPGRNVKNSDMHLLDMESMGKSSDGKAYVITGIWNPNAPMFLVLNEETPKDKDLKCSFELVFHLYNSSLFYCIKEFVLCQLFLHMTYFCVSDKRVYMTVAVDMVVTEVVEPVRFLLETVVRVYPANERFWYFSRKTFTETFYMKLKRSEGKSRTNAGDPIYEVASLRRESTREEQLLSPTSGGGPVSSQEDEAEEESDNELSSGTGDVSKDCPEKILYSWGELLGRWHNNLVVRPNGLATLVKRGVPEALRAEVWQLLAGCHDNEAMLDKYRILITMDSAQENVITRDIHRTFPAHDYFKDTEGDGQESLYKICKAYSVYDEDIGYCQGQSFLAAVLLLHMPEEQAFCVFVKIMYDYGLRDLYRNNFEDLHCKFFQLEKLMQEQLPDLHSHFSDLNLEAHMYASQWFLTLFTAKFPLCMVFHIIDLLLCEGMNVIFHVALALLKTSKEDLLQADFEGALKFFRVQLPKRYRAEENARRLMEQACNIKVRQSKLKKYEREYQTMRESQLQQEDPMDRYKRENRRLQEASMRLEQENDDLAHELVTSKIALRNDLDQAEDKADVLNKELLLTKQRLVETEEEKRKQEEETAQLKEVFRKQLEKAESEIKKTTAIIADYKQICSQLSTRLEKQQTASKDELEGKVMACKHCSEIFSKEGTLKLPALSLDNKGLEIDDEKDALKKQLREMELELAQTKLQLVEAKCKIQELEHQRGALMNEIQAAKNSWFSKTLNSIKTATGKKTQKRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UGT8</accession>
    <name>A0A8C2UGT8_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Inosine triphosphate pyrophosphatase</fullName>
            <shortName evidence="13">ITPase</shortName>
            <shortName evidence="13">Inosine triphosphatase</shortName>
            <ecNumber evidence="13">3.6.1.66</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Non-canonical purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Non-standard purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Nucleoside-triphosphate diphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Nucleoside-triphosphate pyrophosphatase</fullName>
            <shortName evidence="13">NTPase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">XTP/dITP diphosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 14" type="primary">ITPA</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Pyrophosphatase that hydrolyzes the non-canonical purine (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ITP + H2O = IMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:29400"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(6)-hydroxy-dATP + H2O = N(6)-hydroxy-dAMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:83971"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:233529"/>
            <dbReference type="ChEBI" id="CHEBI:233530"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:83972"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>XTP + H2O = XMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28610"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:61314"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>dITP + H2O = dIMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28342"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61194"/>
            <dbReference type="ChEBI" id="CHEBI:61382"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:28343"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="13">Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.66" evidence="13"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2UGT8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005037438.1">
        <property type="protein sequence ID" value="ENSCJPP00005027750.1"/>
        <property type="gene ID" value="ENSCJPG00005021462.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000015399"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035870">
        <property type="term" value="F:dITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036220">
        <property type="term" value="F:ITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036222">
        <property type="term" value="F:XTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009204">
        <property type="term" value="P:deoxyribonucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00515">
        <property type="entry name" value="HAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.950.10:FF:000003">
        <property type="entry name" value="Inosine triphosphate pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03148">
        <property type="entry name" value="HAM1_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027502">
        <property type="entry name" value="ITPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="RdgB/HAM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067:SF9">
        <property type="entry name" value="INOSINE TRIPHOSPHATE PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
        <property type="entry name" value="INOSINE TRIPHOSPHATE PYROPHOSPHATASE/HAM1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="ITPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 13" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="13"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="71"/>
            <end position="72"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="148"/>
            <end position="151"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="176"/>
            <end position="177"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00093218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00093255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00093271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005027750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="201" mass="21846" checksum="E080C1C719D8D07D" modified="2022-01-19" version="1">MAAPGRRSVVFVTGNAKKLEEVTQILGDSSPYTLVAKKIDLPEYQGEPDEISVQKCREAARQIRGPVIVEDTCLCFNVGVLCSAGITLTPASSLCCSGLYKLLAGFEDKSAYALCTFAFSTGNPEEPVKLFKGQTHGVIVEPRGPRDFGWDPCFQPDGYDQTYAELPKAVKNSISHRYRALSELSAFFLQSNPTESPSVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UHQ8</accession>
    <name>A0A8C2UHQ8_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CLN6 transmembrane ER protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">CLN6</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UHQ8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005036612.1">
        <property type="protein sequence ID" value="ENSCJPP00005027036.1"/>
        <property type="gene ID" value="ENSCJPG00005020996.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00400000022240"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035727">
        <property type="term" value="F:lysophosphatidic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120146">
        <property type="term" value="F:sulfatide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001573">
        <property type="term" value="P:ganglioside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030203">
        <property type="term" value="P:glycosaminoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031987">
        <property type="term" value="P:locomotion involved in locomotory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007042">
        <property type="term" value="P:lysosomal lumen acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045862">
        <property type="term" value="P:positive regulation of proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029255">
        <property type="entry name" value="CLN6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16244">
        <property type="entry name" value="CEROID-LIPOFUSCINOSIS NEURONAL PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16244:SF2">
        <property type="entry name" value="CEROID-LIPOFUSCINOSIS NEURONAL PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15156">
        <property type="entry name" value="CLN6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005027036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="348" mass="40048" checksum="DFC395AF4FD33C53" modified="2022-01-19" version="1">MLYLSVLPPPLLRAQLCPYTTDPNPPSSKAHSLAGHVALETSPALPIPTGLISPSIPTRHGAAKSEDTSKTSPFHLDLWFYFTLQNWVLDFGRPIAMIILPLEWFPLNKPSAGDYFHMAYNVITPFLLLKLIERSPKTLPRSMVYVSIITFVMGASIHLVGDSVNHRLIFSGYQHHLSVRENPIIRNLKPETLIDSFELLYYYDEYLGHSMWYIPFFLILFIYFTGCFTPNVDESRMPVSALLLTGPSSLYYWYLVTEGQIFILYIFTFFAMMALVMHQKRKGLVLDSNGLFLFYSFIITLVLIAVWVAWLWNDKTLRKKYPGVIYIPEPWAFYTLHMSNMHTAKESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UKB9</accession>
    <name>A0A8C2UKB9_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cytochrome c oxidase assembly protein COX11, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">COX11</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with CNNM4/ACDP4. Interacts with RANBP2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2UKB9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005037338.1">
        <property type="protein sequence ID" value="ENSCJPP00005027658.1"/>
        <property type="gene ID" value="ENSCJPG00005021411.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000007512"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006754">
        <property type="term" value="P:ATP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.370.10:FF:000001">
        <property type="entry name" value="COX11 cytochrome c oxidase assembly homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.370.10">
        <property type="entry name" value="Ctag/Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00155">
        <property type="entry name" value="CtaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023471">
        <property type="entry name" value="CtaG/Cox11_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007533">
        <property type="entry name" value="Cyt_c_oxidase_assmbl_CtaG"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003465">
        <property type="entry name" value="PRK05089.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21320:SF3">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX11, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21320">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04442">
        <property type="entry name" value="CtaG_Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110111">
        <property type="entry name" value="Ctag/Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00063165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00068998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005027658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="232" mass="26281" checksum="7C377F16499D21D1" modified="2022-01-19" version="1">MALRAVSLCRAVTRPCYGGWTALSPPVRWVRSSNPFTRQQEEEWRRRNRTVLAYIAAAAVGMVGMSYAAVPLYRLYCQATGLGGTTGAGRGAERLQEMRPVKERVLKVTFNADVHAGLQWNFRPQQSEIYVVPGETALAFYKAKNPTDKPIIGISTYNVVPFEAGQYFNKIQCFCFEEQWLNPQEEVDMPVFFYIDPEFAEDPKMAKVDSITLSYTFFEAKEGQHLPLPGFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y4M1</accession>
    <name>A0A8C2Y4M1_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">E2F transcription factor 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">E2F5</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the E2F/DP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y4M1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005000249.1">
        <property type="protein sequence ID" value="ENSCJPP00005000108.1"/>
        <property type="gene ID" value="ENSCJPG00005000182.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157353"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001650">
        <property type="term" value="C:fibrillar center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001216">
        <property type="term" value="F:DNA-binding transcription activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd14660">
        <property type="entry name" value="E2F_DD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000430">
        <property type="entry name" value="Transcription factor E2F4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015633">
        <property type="entry name" value="E2F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037241">
        <property type="entry name" value="E2F-DP_heterodim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032198">
        <property type="entry name" value="E2F_CC-MB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003316">
        <property type="entry name" value="E2F_WHTH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12081">
        <property type="entry name" value="TRANSCRIPTION FACTOR E2F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12081:SF35">
        <property type="entry name" value="TRANSCRIPTION FACTOR E2F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16421">
        <property type="entry name" value="E2F_CC-MB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02319">
        <property type="entry name" value="WHD_E2F_TDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01372">
        <property type="entry name" value="E2F_TDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144074">
        <property type="entry name" value="E2F-DP heterodimerization region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="E2F/DP family winged-helix DNA-binding" evidence="8">
        <location>
            <begin position="6"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="187"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="75"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="230"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005000108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="378" mass="41124" checksum="1F86B73C5DC38BB2" modified="2022-01-19" version="1">LLSGADTNGSAGSSCEHSSLVRVGLLALPQAADALAVRQKRRIYDITNVLEGIDLIEKKSKNSIQWKGVGAGCNTKEVVDRLRYLEAEIEDLELKEKELDQQKLWLQQSIKNVMDDSTNHQYPFQEMVYICNCFNGDTLLAIQAPCGTQLEVPIPEMGQNGQKKYQINLKSSSGPIHVLLINKESNSSKPMVFPVPPPDDLAQTPSQPAAPVTPLKPTPATENPPEHGLNQGQQLPETTADTPSESSLQQNSTTPATPYSSLSDSVLYPSLSGDVAQATASSNDYQALLPLDVNCILKPNSFDIAKMEESTGNIGGDIIDELMSSDVAWSLYEQHLWQLSVKSLTNSQYNTTSFPCTNSSVFVILIFAPLSVPCNAFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y4Y4</accession>
    <name>A0A8C2Y4Y4_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2,4-dienoyl-CoA reductase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">DECR1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y4Y4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005000550.1">
        <property type="protein sequence ID" value="ENSCJPP00005000289.1"/>
        <property type="gene ID" value="ENSCJPG00005000371.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153801"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902494">
        <property type="term" value="C:catalytic complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008670">
        <property type="term" value="F:2,4-dienoyl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120162">
        <property type="term" value="P:positive regulation of cold-induced thermogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd05369">
        <property type="entry name" value="TER_DECR_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43658:SF14">
        <property type="entry name" value="2,4-DIENOYL-COA REDUCTASE [(3E)-ENOYL-COA-PRODUCING], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43658">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005000289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="379" mass="40791" checksum="8C7F97FE5BB16623" modified="2022-01-19" version="1">MAVVMIGRSALRGNASVRFLGTGRFFSHGPNVLLQESNAPQAAFFSPLQKVMLPPNSFQGKVAFITGGGTGIGKGMTTALSSLGATCVIASRKLDVLKGTAEEISSKTGNKVHAIQCDVRDPASVKNAVAELIQVAGHPNVVVNNAAGNFISPSERLSANAWKTITDIVLNGTAFVTLEIGKELIKAQKDHRNSLAVCCMPSFYGILYVSIFVQRFFFVFRCIFASKSGAAFLCITTIYAESGSGFVVPSASAKAGVEALSKSLAAEWGKYGMRFNVIQPGPIKTKGAFSRLDPTGMFEKRMIERIPCGRLGTLEEIANLAAYLCSDYASWVNGAVIRLDGGEYVSMAGEFNNLREVLNFLPAIFCSSIWMHNYYVKFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y6E5</accession>
    <name>A0A8C2Y6E5_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Double-strand break repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">MRE11</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Core component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases. The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage. Within the MRN complex, MRE11 possesses both single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. MRE11 first endonucleolytically cleaves the 5' strand at DNA DSB ends to prevent non-homologous end joining (NHEJ) and licence HR. It then generates a single-stranded DNA gap via 3' to 5' exonucleolytic degradation, which is required for single-strand invasion and recombination.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 17">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17 19">Belongs to the MRE11/RAD32 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015707790.1">
        <property type="nucleotide sequence ID" value="XM_015852304.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015707791.1">
        <property type="nucleotide sequence ID" value="XM_015852305.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y6E5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005006698.1">
        <property type="protein sequence ID" value="ENSCJPP00005003865.1"/>
        <property type="gene ID" value="ENSCJPG00005003960.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107308433"/>
    <dbReference type="KEGG" id="cjo:107308433"/>
    <dbReference type="CTD" id="4361"/>
    <dbReference type="GeneTree" id="ENSGT00390000017288"/>
    <dbReference type="OrthoDB" id="30417at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070533">
        <property type="term" value="C:BRCA1-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016605">
        <property type="term" value="C:PML body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008283">
        <property type="term" value="P:cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000729">
        <property type="term" value="P:DNA double-strand break processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110025">
        <property type="term" value="P:DNA strand resection involved in replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007129">
        <property type="term" value="P:homologous chromosome pairing at meiosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042138">
        <property type="term" value="P:meiotic DNA double-strand break formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097552">
        <property type="term" value="P:mitochondrial double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001033">
        <property type="term" value="P:negative regulation of double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000781">
        <property type="term" value="P:positive regulation of double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032206">
        <property type="term" value="P:positive regulation of telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062176">
        <property type="term" value="P:R-loop processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031860">
        <property type="term" value="P:telomeric 3' overhang formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00840">
        <property type="entry name" value="MPP_Mre11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.110.110:FF:000001">
        <property type="entry name" value="Double-strand break repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000011">
        <property type="entry name" value="Double-strand break repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.110">
        <property type="entry name" value="Mre11, capping domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003701">
        <property type="entry name" value="Mre11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038487">
        <property type="entry name" value="Mre11_capping_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007281">
        <property type="entry name" value="Mre11_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041796">
        <property type="entry name" value="Mre11_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00583">
        <property type="entry name" value="mre11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10139">
        <property type="entry name" value="DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10139:SF1">
        <property type="entry name" value="DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04152">
        <property type="entry name" value="Mre11_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000882">
        <property type="entry name" value="DSB_repair_MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01347">
        <property type="entry name" value="Mre11_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 17 19" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13 17 19" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 17 19" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11 17 19" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10 17 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14 17 19" id="KW-0464">Manganese</keyword>
    <keyword evidence="16 17 19" id="KW-0469">Meiosis</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 17 19" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15 17 19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="Mre11 DNA-binding" evidence="21">
        <location>
            <begin position="294"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="507"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="654"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="577"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="593"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="660"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="18">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR000882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000882-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM01347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005003865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="700" mass="80262" checksum="5774A95C3E30BB1F" modified="2022-01-19" version="1">MSAVTLQDDEDTFKILIATDIHLGYLEKDPVRGNDTFVTFNEILEHAQKNEVDFVLLGGDLFHENKPSRKTIHTCLESLRKYCMGDRPVRFEVLSDQAVNFQFSKFPWVNYQDENLNISMPIFSIHGNHDDPTGVDALCALDILSCAGLLNHFGRSTSVEKIDISPILLRKGRTNIALYGLGAIPDERLYRMFVNKQVTMLRPKEDEDSWFNLFVIHQNRSKHGATNYIPEQFLDDFINLVVWGHEHECKITPAQNEQQHFYVTQPGSSVVTSLSPGEAVKKHIGLLRVKGKKMKMQKIALETVRTFYMDDVVLADHPELFNPDNPGVTHTIQTFCREKIEMMLDNAERERLGNPRQPEKPLIRLRVDYTGGFEPFIVHRFSQKYMDRVANPKDIIHFFRHREQKEKNDSDLNFGKLFSRPASEGVTLRVEDLVKQYFQTAEKKVQLSLLTERGMGEAVQEFVDKEEKDAIEELVKFQLEKTQRFLKERHIDAEEEKIDEEVRKFRESRRKNMEEEDEEVREAMTRARAHRPKDVVPDSASSDEEPMDIEMKASGDSDDDIPTTLSRGRGRGRARGARGQNSTARGSSRRGRGSTSQGSSASSRAYKSVPDKNLSIMDAFRSLKPEPSQSTSKFFSEEIIDDELDLEESHISLSSKRNQRFSAMSSFSKRGSQSQTSRGVDFESDEDDPFKTTATSRRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y7E6</accession>
    <name>A0A8C2Y7E6_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Synaptogyrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">SYNGR3</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the synaptogyrin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015732329.1">
        <property type="nucleotide sequence ID" value="XM_015876843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y7E6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005009476.1">
        <property type="protein sequence ID" value="ENSCJPP00005005950.1"/>
        <property type="gene ID" value="ENSCJPG00005005622.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107320699"/>
    <dbReference type="KEGG" id="cjo:107320699"/>
    <dbReference type="CTD" id="9143"/>
    <dbReference type="GeneTree" id="ENSGT00950000182935"/>
    <dbReference type="OrthoDB" id="10041611at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031594">
        <property type="term" value="C:neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042169">
        <property type="term" value="F:SH2 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045055">
        <property type="term" value="P:regulated exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010807">
        <property type="term" value="P:regulation of synaptic vesicle priming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016579">
        <property type="entry name" value="Synaptogyrin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10838">
        <property type="entry name" value="SYNAPTOGYRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10838:SF8">
        <property type="entry name" value="SYNAPTOGYRIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011282">
        <property type="entry name" value="Synaptogyrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51225">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="9">
        <location>
            <begin position="20"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="195"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="208"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR011282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005005950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="230" mass="25130" checksum="A458E5A9831FD799" modified="2022-01-19" version="1">MEGSSFGAGRAGGAVDPVDFLKQPQTILRATAWIFSIVVFGSIVNECYVNKDGTDPELHCIFNENESACSYAIAIGIIAFFGCIFFLVVDLQFQQISSVKDRKRAVLLDLGFSGFLSFLWFVAFCFLANQWQRTTMSKGASQGADAARAAIAFSFFSIIVWVALALKALQRYRLGTDMSLFATDQFATDPNAAYPGYPTGSGIESKETYQSPPFTETSDANPKGYQVPAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y7Z4</accession>
    <name>A0A8C2Y7Z4_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TATA-box binding protein like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TBPL2</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015721338.1">
        <property type="nucleotide sequence ID" value="XM_015865852.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y7Z4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005010511.1">
        <property type="protein sequence ID" value="ENSCJPP00005006719.1"/>
        <property type="gene ID" value="ENSCJPG00005006225.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107315449"/>
    <dbReference type="KEGG" id="cjo:107315449"/>
    <dbReference type="CTD" id="387332"/>
    <dbReference type="GeneTree" id="ENSGT00940000159561"/>
    <dbReference type="OrthoDB" id="2127950at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04516">
        <property type="entry name" value="TBP_eukaryotes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000001">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000002">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00408">
        <property type="entry name" value="TATA_bind_prot_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000814">
        <property type="entry name" value="TBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030491">
        <property type="entry name" value="TBP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033710">
        <property type="entry name" value="TBP_eukaryotic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10126">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00352">
        <property type="entry name" value="TBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00686">
        <property type="entry name" value="TIFACTORIID"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00351">
        <property type="entry name" value="TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="326" mass="36082" checksum="F8132606827EAF24" modified="2022-01-19" version="1">MEDVSPLELYLERCDTQDDPSASPQLFNPMSPYDVDLPIQVAEDASFGSQFNQPKELPEDFSSVDLSFLPDITQDNREQNPAEDGCEMQGGLNGPVQSNEDSGIFMEESGSSYPDSIQPSPGGPGACPPLTPMTPMTPMTPESESSGIVPQLQNIVSTVNLACKLDLKNIALHARNAEYNPKRFAAVIMRIREPRTTALIFSSGKMVCTGAKSEEQSRLAARKYARVVQKLGFPAKFLDFKIQNMVGSCDVRFPIRLEGLVLTHQQFSSYEPELFPGLIYRMVKPRIVLLIFVSGKVVLTGAKERSEIYEAFENIYPILRGFKKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y849</accession>
    <name>A0A8C2Y849_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Homeobox protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">PITX2</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 9 10 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the paired homeobox family. Bicoid subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y849"/>
    <dbReference type="Ensembl" id="ENSCJPT00005011505.1">
        <property type="protein sequence ID" value="ENSCJPP00005007414.1"/>
        <property type="gene ID" value="ENSCJPG00005006843.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154518"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000031">
        <property type="entry name" value="Homeobox protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016233">
        <property type="entry name" value="Homeobox_Pitx/unc30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003654">
        <property type="entry name" value="OAR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45882:SF4">
        <property type="entry name" value="PITUITARY HOMEOBOX 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45882">
        <property type="entry name" value="PITUITARY HOMEOBOX HOMOLOG PTX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03826">
        <property type="entry name" value="OAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000563">
        <property type="entry name" value="Homeobox_protein_Pitx/Unc30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50803">
        <property type="entry name" value="OAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0371">Homeobox</keyword>
    <keyword evidence="8 9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="13">
        <location>
            <begin position="99"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="OAR" evidence="14">
        <location>
            <begin position="282"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="10">
        <location>
            <begin position="101"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005007414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="320" mass="35327" checksum="43F74C22D40BAB76" modified="2022-01-19" version="1">MSCMKDPLSLERLGAGNNKLCSSSPSSSSSSSSCHHQQPSLAMATALAPGQARSSLEAAKHRLEVHTISDTSSPEAAEKEKSQQGKSEDAGPEDPSKKKKQRRQRTHFTSQQLQELEATFQRNRYPDMSTREEIAVWTNLTEARVRVWFKNRRAKWRKRERNQQAELCKNGFGPQFNGLMQPYDDMYPGYSYNNWSFPFFNSMNVNPLSSQTMFSPPSSISSMSMPSGMGHSAVPGMANSGLNSLNNLNNLSNPSLNSAVPTPACPYAPPTPPYVYRDTCNSSLASLRLKAKQHSSFGYASVQNPASNLSACQYAVDRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y962</accession>
    <name>A0A8C2Y962_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein uS2m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">28S ribosomal protein S2, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">MRPS2</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Required for mitoribosome formation and stability, and mitochondrial translation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y962"/>
    <dbReference type="Ensembl" id="ENSCJPT00005013802.1">
        <property type="protein sequence ID" value="ENSCJPP00005009217.1"/>
        <property type="gene ID" value="ENSCJPG00005008132.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000017382"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061668">
        <property type="term" value="P:mitochondrial ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000026">
        <property type="entry name" value="28S ribosomal protein S2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00291_B">
        <property type="entry name" value="Ribosomal_uS2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_uS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005706">
        <property type="entry name" value="Ribosomal_uS2_bac/mit/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_uS2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_uS2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S2 PROKARYOTIC AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="Ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00962">
        <property type="entry name" value="RIBOSOMAL_S2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00059792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00071390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00083109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005009217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="345" mass="38080" checksum="BAB2990460CD99D5" modified="2022-01-19" version="1">MGSPVSAEAGELQEALGQRAAHPRAAAGRGALGGLRLCHGGTRDRVARQQLRGSGRFGSSSSSSGTAMAVMRFLRAGERLYSGLPAPAALTAAARPRGECGTAPALPLYPDLEDKLLTEPLRHPDFFNVKELFSLKDLFDARVHLGHKKGCRHQFMEPYIFGCRLDQDIIDLDQTMQHLQLALNFTAHIAYRKGIILFVSRNRQFCHLIESTARECGEYAHTRYWQGGLLTNAHIQFGPGIRLPDLLIFLSSLNNVFEPHVAIRDAAKMNIPTVGVVDTNCNPCLITYPIPGNDDSPTAMELYCKLFKMTIIRAKNKRKQLEVFQELQSQEKSDTNRPVLSGGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y9I8</accession>
    <name>A0A8C2Y9I8_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transmembrane protein 125</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">TMEM125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015725547.1">
        <property type="nucleotide sequence ID" value="XM_015870061.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032302085.1">
        <property type="nucleotide sequence ID" value="XM_032446194.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032302086.1">
        <property type="nucleotide sequence ID" value="XM_032446195.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032302087.1">
        <property type="nucleotide sequence ID" value="XM_032446196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y9I8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005015390.1">
        <property type="protein sequence ID" value="ENSCJPP00005010380.1"/>
        <property type="gene ID" value="ENSCJPG00005009048.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107317410"/>
    <dbReference type="KEGG" id="cjo:107317410"/>
    <dbReference type="CTD" id="128218"/>
    <dbReference type="GeneTree" id="ENSGT00390000003015"/>
    <dbReference type="OrthoDB" id="8950495at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028165">
        <property type="entry name" value="TMEM125"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31416">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 125"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31416:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 125"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15109">
        <property type="entry name" value="TMEM125"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005010380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="220" mass="23723" checksum="F1E5387AB9D490D0" modified="2022-01-19" version="1">MPELADLSSPRTPADADHIQRNILEEHVELWWFQDPKKSILCYGMAVVLILACGIGGIILLYSTSSRSGEWRLAVGTTLCLLALLVLLKQLLSSAIQDMNCIRSRHQIELLKSGGFSDCLVLLLSALVLLVCGVVLTILSTTNMQLSPARPLASMFTSGVVLLAAGSTLLLCLLLYLLCTSCCQAAPRGLETGEIRVFTISGRLAANRRLPPTSSMANLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YAZ1</accession>
    <name>A0A8C2YAZ1_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Transmembrane protein 63B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">TMEM63B</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015713171.1">
        <property type="nucleotide sequence ID" value="XM_015857685.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YAZ1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005019197.1">
        <property type="protein sequence ID" value="ENSCJPP00005013347.1"/>
        <property type="gene ID" value="ENSCJPG00005010350.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107311284"/>
    <dbReference type="KEGG" id="cjo:107311284"/>
    <dbReference type="CTD" id="55362"/>
    <dbReference type="GeneTree" id="ENSGT00940000157084"/>
    <dbReference type="OrthoDB" id="1689567at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140135">
        <property type="term" value="F:mechanosensitive monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990760">
        <property type="term" value="F:osmolarity-sensing monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120019">
        <property type="term" value="F:phosphatidylcholine transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017128">
        <property type="term" value="F:phospholipid scramblase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140338">
        <property type="term" value="F:sphingomyelin transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042756">
        <property type="term" value="P:drinking behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036335">
        <property type="term" value="P:intestinal stem cell homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007605">
        <property type="term" value="P:sensory perception of sound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160069">
        <property type="term" value="P:surfactant secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF38">
        <property type="entry name" value="CSC1-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="42"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="436"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="480"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="524"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="578"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="627"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="686"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="717"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="11">
        <location>
            <begin position="124"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="12">
        <location>
            <begin position="246"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="10">
        <location>
            <begin position="439"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="783"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="790"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="808"/>
            <end position="819"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005013347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="829" mass="94766" checksum="1D9AC4F3E7E90C2C" modified="2022-01-19" version="1">MLPYVIATLGSGGASCKASTCSNSTKDYCYSARIRSTVLQGLPFGGVPTVLALDFMCFLALLFVFSILRKVAWDYGRLALVTDADRRRRWQTEREEREYVASALHSDNHDRYERLTSVSSSVDFDQRDNGFCSWLTAIFRIKDDEIRDKCGGDAVHYLSFQRHIIGLLVAVGVLSVAVILPVNFSGDLLENNAYSFGRTTIANLNSGNNLLWLHTSFAFLYLLLTVYSMRRHTSKMRYKEDDLVKRTLFINGISKYAEPEKIKKHFEEAYANCTVLEARPCYDVARLMFLDAERKKAERGRIYFTNLQSKENTPSMINPKPCGHLCCCVIRGCEEVEAIEYYTKLEEKLKDDYKREKEKVNEKPLGMAFVTFHNETITAIILKDFNACKCQGCACRGEPRASSCSESLHVSNWTVSYAPDPQNIYWEHLSIRGFIWWIRCLVINVVLFILLFFLTTPAIIITTMDKFNVTKPVEYLNNPIITQFFPTLLLWCFSALLPTIVYYSAFFEAHWTRSGENRTTMHKCYTFLIFMVLLLPSLGLSSLDVFFRWLFDKKFLAEAAVRFECVFLPDNGAFFVNYVIASAFIGNAMDLLRIPGLLMYMIRLCLARSAAERRNVKRHQAYEFQFGAAYAWMMCVFTVVMTYSITCPIIVPFGLMYMLLKHLVDRYNLYYAYLPAKLDKKIHSGAVNQVVAAPILCLFWLLFFSTMRAGFLAPTSMFTFVVLVITIVICLCHVCFGHFKYLSAHNYKIEHTEVDATESRQNGRPATNLPAPKSAKYIAQVLQDSSPEGEATESEEQGSQDEELITTDGMNDTDFQSCEDSLIENEIRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YDK7</accession>
    <name>A0A8C2YDK7_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">CDC42 small effector 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">CDC42SE1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CDC42SE/SPEC family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015740154.1">
        <property type="nucleotide sequence ID" value="XM_015884668.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015740155.1">
        <property type="nucleotide sequence ID" value="XM_015884669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YDK7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005026058.1">
        <property type="protein sequence ID" value="ENSCJPP00005018789.1"/>
        <property type="gene ID" value="ENSCJPG00005015260.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107324559"/>
    <dbReference type="KEGG" id="cjo:107324559"/>
    <dbReference type="CTD" id="56882"/>
    <dbReference type="GeneTree" id="ENSGT00940000160112"/>
    <dbReference type="OrthoDB" id="5559822at2759"/>
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        <property type="component" value="Chromosome 25"/>
    </dbReference>
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        <property type="term" value="C:cell junction"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:small GTPase binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:regulation of cell shape"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035023">
        <property type="term" value="P:regulation of Rho protein signal transduction"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="CDC42 small effector protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
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    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039056">
        <property type="entry name" value="SPEC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13502:SF3">
        <property type="entry name" value="CDC42 SMALL EFFECTOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13502">
        <property type="entry name" value="CDC42 SMALL EFFECTOR PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0564">Palmitate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005720"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005018789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="78" mass="8858" checksum="3FF5EDEF8B83B1A8" modified="2022-01-19" version="1">MSDFWHKLGCCVVEKPQPKKRRRRIDRSMIGEPMNFVHLTHIGSGDMAAGEGMPMTGAVQEMRSKGGRERQWSSSRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YE53</accession>
    <name>A0A8C2YE53_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transmembrane protein 222</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">TMEM222</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YE53"/>
    <dbReference type="Ensembl" id="ENSCJPT00005027391.1">
        <property type="protein sequence ID" value="ENSCJPP00005019811.1"/>
        <property type="gene ID" value="ENSCJPG00005016031.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000007371"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008496">
        <property type="entry name" value="TMEM222/RTE1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20921">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 222"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20921:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 222"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05608">
        <property type="entry name" value="RTE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005019811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="151" mass="17146" checksum="E1A502B1937F8BFF" modified="2022-01-19" version="1">MKQFNGGGGAGLDAERGRFPYCVVWTPIPVLTWLFPIIGHMGICTSTGVIRDFAGPYFVSEQQQQRGPICPCISRYWKLDPGKVYSSSPNAWDTAVHDASEEYKHRMHNLCCDNCHSHVALALNLMRYDNSTSWNMVKLCFFSLLYGKYVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YF17</accession>
    <name>A0A8C2YF17_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rho GTPase activating protein 31</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ARHGAP31</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="Ensembl" id="ENSCJPT00005029876.1">
        <property type="protein sequence ID" value="ENSCJPP00005021804.1"/>
        <property type="gene ID" value="ENSCJPG00005017407.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159458"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051576">
        <property type="entry name" value="PX-Rho_GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15729">
        <property type="entry name" value="CDC42 GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15729:SF3">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="343"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="486"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="550"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="656"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="857"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="960"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1101"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="379"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="432"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="493"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="675"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="872"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1101"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1112"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1141"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1158"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1256"/>
            <end position="1278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005021804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1323" mass="144891" checksum="514F7EEB882F4F7D" modified="2022-01-19" version="1">MTNMHTRNLALVWAPNLLRSKEIEAVGCNGDAAFLEVRVQQLVIEFILNHVDQIFSNNRKASSAESIENAPVVKNLTHPSTSLPMKLVSLEEAQARSLSASHPARKERRENSLPEIVPVTGSFFHTVVDLPDSKRKLSTKSKKWKSIFNLGRSGSESKSKLSRNGSVFVRAQKLSEKATIRPAKSMDSLCSLPVEGEDDKSRFKRTVTTGGFFVPVMKTRTGGTGSSYDLSKENEWEREGCVMAAKGNSELSGVKAPCRTSQAKCPPEQLKVFRAAEDAENEQTSPKGGRMFYTSETAAKSGFPSSLFPLEASPRHQRKALNISEPFAVSVPLRVSAVISTNSTPCRVPTRDKPSLSSLEELSSLVPESPSPSTLEGGGHMKMEQAPERKEKPPGPLLPTAASRGSLPEELVVARKSETLETAEPAAENQETLHGQSSSTSSLQQSSEHSPTAEQAPASEVHMGPLAAVKTEQEKVEMKTIFPEGSCSQQEIQKAKPEEGSCIKDVTEKDPANTLLEPLWPEIQHELKIIEPEEELLLFPAAVPKTVPVSESSSSVQTNIFSSGPEQCTTLSEQKSAGRTPQTTTQVPLFDATNTEQPDSHQNYQSDVAAQQSCASALPKLGTPLTSVAAPKNHHSVVEDSMRECVTSPLELNFHSQPEVNELPPGDEFSLSKGAHSESEKGKDSTCQLQKESDDHTKVQTRSEMPEIVTADRRDTLSSKALNGAGIQELKEGNAVSRTHDAGDQDDEDNWVDNVQSLELVEPWEDHQWVTSPLHSPTFKDIQEKTIPEFQPQDQRSEAGLSLRPRFSRSLSLDSKDTVMSLWTIPFSFIDAPEQQQPCSDILPLEMPKKSISPISLGKAKQDENNTCLPEEPLKTDELRYPISREETPAKQEPSRILPEPEGIKMDVSKENPWRSKLEQFLPYQNAPNSSLQAKITKEESSRSQDIALAEDTVTKVCSATESLQSNKDEETPRKVKTRPSSLNLDSLLPTPDFLTFESLAMPSAAGNFLYGQKEVKSSDSVPSLSTTCPAGAKGVSWRSPFSAHVDLDLDYLAVAHATTGRRNSAPVSVSAVRTSFMIKMCQARAVPVIPPKIQYTQIPQPLQAQNSAPQVEKKEAEAKQAGRQTQRVAWGHLEPPKSPVTEKKAKAEKENSDPAQKDSTCPWNNSIGSPLESSQSSHNPSLDAPVLRRKRTSEGETGGDNPQSSKMERPSGFSKPSYRSRPGRPQSLILFSPPFPIMDHPSSSADSRVLLSPIRSPTQTSSSSPICGDLSETSRTTPEGVMLRNKMTIPKNGQRLETSTSCFYQPQRRSVILDGRSGRQIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YFZ2</accession>
    <name>A0A8C2YFZ2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">medium-chain acyl-CoA ligase</fullName>
            <ecNumber evidence="13">6.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">ACSM3</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a medium-chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:48340"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:59558"/>
            <dbReference type="ChEBI" id="CHEBI:90546"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:48341"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.2" evidence="13"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2YFZ2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005032466.1">
        <property type="protein sequence ID" value="ENSCJPP00005023738.1"/>
        <property type="gene ID" value="ENSCJPG00005018771.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157930"/>
    <dbReference type="OrthoDB" id="6614653at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004321">
        <property type="term" value="F:fatty-acyl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018729">
        <property type="term" value="F:propionate CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000007">
        <property type="entry name" value="Acyl-coenzyme A synthetase ACSM2A, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000005">
        <property type="entry name" value="Acyl-coenzyme A synthetase ACSM5, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051087">
        <property type="entry name" value="Mitochondrial_ACSM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43605">
        <property type="entry name" value="ACYL-COENZYME A SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43605:SF7">
        <property type="entry name" value="ACYL-COENZYME A SYNTHETASE ACSM3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="15">
        <location>
            <begin position="69"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="16">
        <location>
            <begin position="484"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005023738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="578" mass="64805" checksum="7E9E2D7B9581C2FB" modified="2022-01-19" version="1">MRCLLKALNVVSLHASLRRSRQLCSQSSPAQTSFSYELMKQQYRPEVPEYFNFASNVLDRWTEVEKEGKKPKTPALWWVDGDGEEVKWSFEELGVLSRKAANVLSGACSLQCGDRVLLLLPRIPEWWLLNVACMRTGTIPIPGTQQLTAKDILYRLQKSKAKGVITDDSVASTVESVEAECQSLKFKLLVSEGHREGWLSFKDLLKNASSDHRCVTTKSQHPMAIYFTSGTTGAPKMTEHSHCSYGIGLTVSGRYWLNLTSSDIYWNTSDTGWAKAAWSIFSAWIQGACVFVHKMPQFSPPAVFETLSRYPITVFCSAPTAYRMLVQHQPASCTLSSLRHCVSAGEPINPEVMAAWKAQTGLNIHECYGQTETVLVCGNFKGMEIKPGSMGKPSPGYDVQIIDENGNILPPGKEGEIAIKVKPTRPLFLFTCYADDPEKTKATVRGDFYVTGDRGLRDEDGYFWFVGRADDVINSAGYRIGPFEVESALLEHPAVVESAVVSSPDPIRGEVVKAFVVLTPNYASHDPEKMMKELQDHVKKATAPYKYPRKMEFVRELPKTVSGKIRRNELRQKEWRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YG07</accession>
    <name>A0A8C2YG07_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Family with sequence similarity 199, X-linked</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FAM199X</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM199 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015716278.1">
        <property type="nucleotide sequence ID" value="XM_015860792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YG07"/>
    <dbReference type="Ensembl" id="ENSCJPT00005032557.1">
        <property type="protein sequence ID" value="ENSCJPP00005023822.1"/>
        <property type="gene ID" value="ENSCJPG00005018831.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107312936"/>
    <dbReference type="KEGG" id="cjo:107312936"/>
    <dbReference type="CTD" id="139231"/>
    <dbReference type="GeneTree" id="ENSGT00440000033895"/>
    <dbReference type="OrthoDB" id="6365484at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029672">
        <property type="entry name" value="FAM199X_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32003">
        <property type="entry name" value="PROTEIN FAM199X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32003:SF1">
        <property type="entry name" value="PROTEIN FAM199X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15814">
        <property type="entry name" value="FAM199X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="268"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="268"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="343"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005023822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="381" mass="42393" checksum="3B636BDF6BEBD45F" modified="2022-01-19" version="1">MTEELYEKFLAPDEPCPLLSHQHPPRGGSLSEEGCLDVSDFGCQLSSCHRTDPLHRFHSNRWNLTSCGTSVASSECSEELFSSVSVGDQDDCYSLLDDQEFTSFDLFPEGSVCSDVSSSISTYWDWSDSEFEWQLPGSDITSGSDVLSDVIPSIPSSPCLLPKKKNKHRNLDELPWSAMTNDEQVEYIEYLSRKVSTEMGLREQLDIIKIIDPTAQISPTDSEFIIELNCLTDEKLKQVRNYIKEHGPRQRSARENWKRSSYSCASTSGVSGASVSSSSASMVSSASSSGSSVANSASNSSANMSRAHSDSNLSTSAAERIRDSKKRSKQRKLQQKALRKRQLKEQRQARKERLSGLFLNEEVLSLKVTEEDHEGDVDVLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YGU3</accession>
    <name>A0A8C2YGU3_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Polycomb group RING finger protein 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">RING finger protein 134</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">PCGF6</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Transcriptional repressor. May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of a PRC1-like complex. Interacts with BMI1/PCGF4, RING1 and RNF2. Interacts with KDM5D. Interacts with CBX4, CBX6, CBX7 and CBX8.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2YGU3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005034652.1">
        <property type="protein sequence ID" value="ENSCJPP00005025491.1"/>
        <property type="gene ID" value="ENSCJPG00005019996.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158034"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035102">
        <property type="term" value="C:PRC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd17085">
        <property type="entry name" value="RAWUL_PCGF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16738">
        <property type="entry name" value="RING-HC_PCGF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000033">
        <property type="entry name" value="Polycomb group RING finger protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000193">
        <property type="entry name" value="Polycomb group RING finger protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051507">
        <property type="entry name" value="PcG_RING_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046979">
        <property type="entry name" value="PCGF6_RAWUL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038037">
        <property type="entry name" value="PCGF6_RING-HC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032443">
        <property type="entry name" value="RAWUL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45893">
        <property type="entry name" value="POLYCOMB GROUP RING FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16207">
        <property type="entry name" value="RAWUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 17" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="19">
        <location>
            <begin position="166"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="55"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00054318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00062275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00072770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00080454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005025491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="423" mass="46668" checksum="92DB5C625241472E" modified="2022-01-19" version="1">MLFCDSRGEGKAPPPVSGRALGASFCDAAGRALREPGLSACWCAVPQAAAQPSARAMDADGDAGSVVSGLSGGDGAGAGPADEEQEMEGAPGCSGSRSLPFEFERSRSESSGDEDDEDDDEEEEMEEEELEGDAGGRFGTDDGELDSDDDRERMINLAELTPYILCSICKGYFIDATTITECLHTFCKSCIVRHFYYSNRCPKCNIVVHQTQPLYNIRLDRQLQDIVYKLVVNLEEREKKQMHDFYKERGLEVPKPAVPQPVPASRGRPRKVLGSVFRIPPELDISILLEFIGLPLLLTCLSAQCSENSHTANEGTGNFKPLEKKFVRVSGEATIGHVEKFLRRKMDLDPACQVDIICGDHLLEHYQTLREIRQVIGESAVQVQNFSILKRAPVLLMINYTSHRNEEDKTTGNKLASNIMSLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YH30</accession>
    <name>A0A8C2YH30_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YH30"/>
    <dbReference type="Ensembl" id="ENSCJPT00005035322.1">
        <property type="protein sequence ID" value="ENSCJPP00005026044.1"/>
        <property type="gene ID" value="ENSCJPG00005020329.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00960000188661"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005026044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="136" mass="14915" checksum="BA42DC916351C255" modified="2022-01-19" version="1">MWLPFLRGSPKALMTLPKASSPLLIWMLSFSLSPVFPVLTIRSEPARSTKWNLETRTCPEAGMVGWLDSARRVTRPAPRRCSIVTVKMVCERLDCALMCVAPVCLAVLPISSRLSTSSSPSTSDSFTPQSTAMANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2026-01-28" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q6PRV1</accession>
    <name>Q6PRV1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Ferritin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">FTH1</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2004-03" db="EMBL/GenBank/DDBJ databases">
            <title>Coturnix japonica ferritin gene.</title>
            <authorList>
                <person name="Hartl M."/>
                <person name="Bister K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>4 Fe(2+) + O2 + 4 H(+) = 4 Fe(3+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.16.3.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Autophagosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Lysosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the ferritin family.</text>
    </comment>
    <dbReference type="EMBL" id="AY583753">
        <property type="protein sequence ID" value="AAT01287.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015719168.1">
        <property type="nucleotide sequence ID" value="XM_015863682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6PRV1"/>
    <dbReference type="SMR" id="Q6PRV1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005030612.1">
        <property type="protein sequence ID" value="ENSCJPP00005022324.1"/>
        <property type="gene ID" value="ENSCJPG00005017811.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107314460"/>
    <dbReference type="KEGG" id="cjo:107314460"/>
    <dbReference type="CTD" id="2495"/>
    <dbReference type="GeneTree" id="ENSGT00950000182841"/>
    <dbReference type="OrthoDB" id="186462at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01056">
        <property type="entry name" value="Euk_Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1260.10:FF:000024">
        <property type="entry name" value="Ferritin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001519">
        <property type="entry name" value="Ferritin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014034">
        <property type="entry name" value="Ferritin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11431">
        <property type="entry name" value="FERRITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11431:SF37">
        <property type="entry name" value="FERRITIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00540">
        <property type="entry name" value="FERRITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00204">
        <property type="entry name" value="FERRITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="8 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="4 14" id="KW-0409">Iron storage</keyword>
    <keyword evidence="9" id="KW-0458">Lysosome</keyword>
    <keyword evidence="6 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin-like diiron" evidence="15">
        <location>
            <begin position="10"/>
            <end position="159"/>
        </location>
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        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
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        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
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        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004419"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022434"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        </source>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00047990"/>
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        <source>
            <dbReference type="PIRSR" id="PIRSR601519-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AAT01287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005022324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="181" mass="21222" checksum="0AEB8787213E5EF3" modified="2004-07-05" version="1">MATPPSQVRQNYHQDCEAAINRQINLELYASYVYLSMSYYFDRDDVALKNFAKYFLHQSHEEREHAEKLMKLQNQRGGRIFLQDIKKPDRDDWENGLTAMECALHLEKNVNQSLLELHKLATEKNDPHLCDFIETHYLDEQVKAIKQLGDHVTNLRKMGAPKYGMAEYLFDKHTLGECDNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2026-01-28" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q8SEW7</accession>
    <name>Q8SEW7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 16">NADH-ubiquinone oxidoreductase chain 3</fullName>
            <ecNumber evidence="3 16">7.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">ND3</name>
        <name evidence="20" type="synonym">MT-ND3</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <geneLocation type="mitochondrion" evidence="18 20"/>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2001" name="Anim. Genet." volume="32" first="380" last="385">
            <title>Complete sequence of the Japanese quail (Coturnix japonica) mitochondrial genome and its genetic relationship with related species.</title>
            <authorList>
                <person name="Nishibori M."/>
                <person name="Hayashi T."/>
                <person name="Tsudzuki M."/>
                <person name="Yamamoto Y."/>
                <person name="Yasue H."/>
            </authorList>
            <dbReference type="PubMed" id="11736810"/>
            <dbReference type="DOI" id="10.1046/j.1365-2052.2001.00795.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <tissue evidence="18">Whole blood</tissue>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2021" name="Gene" volume="145841" first="0" last="0">
            <title>When good mitochondria go bad: Cyto-nuclear discordance in landfowl (Aves: Galliformes).</title>
            <authorList>
                <person name="Kimball R.T."/>
                <person name="Guido M."/>
                <person name="Hosner P.A."/>
                <person name="Braun E.L."/>
            </authorList>
            <dbReference type="PubMed" id="34274481"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Mitochondrion membrane</location>
            <topology evidence="1 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the complex I subunit 3 family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.2" evidence="3 16"/>
    <dbReference type="EMBL" id="AP003195">
        <property type="protein sequence ID" value="BAB62922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW574361">
        <property type="protein sequence ID" value="QXU59989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_572021.1">
        <property type="nucleotide sequence ID" value="NC_003408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SEW7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005000026.1">
        <property type="protein sequence ID" value="ENSCJPP00005000009.1"/>
        <property type="gene ID" value="ENSCJPG00005000026.1"/>
    </dbReference>
    <dbReference type="GeneID" id="804659"/>
    <dbReference type="KEGG" id="cjo:804659"/>
    <dbReference type="CTD" id="4537"/>
    <dbReference type="GeneTree" id="ENSGT00390000011605"/>
    <dbReference type="OrthoDB" id="154075at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1610:FF:000004">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1610">
        <property type="entry name" value="NADH:ubiquinone/plastoquinone oxidoreductase, chain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000440">
        <property type="entry name" value="NADH_UbQ/plastoQ_OxRdtase_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038430">
        <property type="entry name" value="NDAH_ubi_oxred_su3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11058">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11058:SF9">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00507">
        <property type="entry name" value="Oxidored_q4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0249">Electron transport</keyword>
    <keyword evidence="14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="13 16 18" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11 16" id="KW-0520">NAD</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="17" id="KW-0732">Signal</keyword>
    <keyword evidence="8 16" id="KW-1278">Translocase</keyword>
    <keyword evidence="7 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 16" id="KW-0813">Transport</keyword>
    <keyword evidence="12 16" id="KW-0830">Ubiquinone</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044738132" description="NADH-ubiquinone oxidoreductase chain 3" evidence="17">
        <location>
            <begin position="27"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="BAB62922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="QXU59989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005000009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="116" mass="13088" checksum="E08E137051898CDA" modified="2002-06-01" version="1">MNTLTFMLSASLILSTLLTTVNFWLAQMTPDTEKLSPYECGFDPLGSARLPFSIRFFLVAILFLLFDLEIALLLPLPWAIQLQSPMTTLTWATTILTLLTLGLIYEWTQGGLEWAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SJX3</accession>
    <name>A0A8C2SJX3_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">G protein-coupled receptor 107</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">GPR107</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SJX3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005000075.1">
        <property type="protein sequence ID" value="ENSCJPP00005000031.1"/>
        <property type="gene ID" value="ENSCJPG00005000055.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160451"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032050">
        <property type="term" value="F:clathrin heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054103">
        <property type="entry name" value="CAND6-7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053937">
        <property type="entry name" value="GOST_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009637">
        <property type="entry name" value="GPR107/GPR108-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229">
        <property type="entry name" value="LUNG SEVEN TRANSMEMBRANE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229:SF12">
        <property type="entry name" value="PROTEIN GPR107"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
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    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034762892" evidence="8">
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            <begin position="26"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <begin position="327"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <begin position="365"/>
            <end position="383"/>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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            <begin position="395"/>
            <end position="417"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <begin position="447"/>
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        </location>
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            <begin position="475"/>
            <end position="494"/>
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            <begin position="29"/>
            <end position="104"/>
        </location>
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            <begin position="257"/>
            <end position="503"/>
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            <begin position="150"/>
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            <dbReference type="Pfam" id="PF06814"/>
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            <dbReference type="Pfam" id="PF21904"/>
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            <dbReference type="Ensembl" id="ENSCJPP00005000031.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="551" mass="62169" checksum="1B48C9522D9A261D" modified="2022-01-19" version="1">MAALGLPAALTVAVLALFCVGPAGARVHHLTLKDDVRQKVHLNTFGFFKNGFMTVNVSNLSLKPPVNTDDKGSSSVGFSLDRTRNDGFSTYLDEEVDYCILNKKPEQGVSVVILLLDFKNDVVKVRFSAEASHLLPKISFVSEENATALITKPPKSEDKSPTETNKNTDGTVTRSKRSTTSSQSIVEQQHPVHNDRGTISFQFFFNISSDNQEGLYSLYFHKCIGGDGKTRDQQLFSLDIEITEKNPESYLSAGEIPLPKLYISMALFFFLSGTVWIHILRKRRNEVFKIHWLMAALPFTKSLSLVFHAIDYHYISSQGFPIEGWAVVYYITHLFKGALLFITIALIGTGWAFIKHILSDKDKKIFMIVIPLQVLANVAYIIIESTEEGTTEYGLWKEILFLVDLLCCGAILFPVVWKILSINFLMDFCVLLTAAINLAKLKLFRHYYVMIVCYIYFTQIIAILIKIAVPFQWKWLYQLLNEMATLVFFVLTGYKFRPASDNPYLQLSQDDEDDLEMEAVVTTSGVMEGMKKVKKVVNGSAEPRGEWESTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SNM0</accession>
    <name>A0A8C2SNM0_COTJA</name>
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        <submittedName>
            <fullName evidence="2">Sperm microtubule inner protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">SPMIP2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SNM0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005000994.1">
        <property type="protein sequence ID" value="ENSCJPP00005000546.1"/>
        <property type="gene ID" value="ENSCJPG00005000640.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000012736"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027814">
        <property type="entry name" value="DUF4562"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34833">
        <property type="entry name" value="GENE, 17359-RELATED"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR34833:SF1">
        <property type="entry name" value="GENE, 17359-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="DUF4562"/>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
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        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005000546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="195" mass="22026" checksum="EBC5C3E324B1BF0C" modified="2022-01-19" version="1">MVQQSHGATQAGRAPLPHGTSGCQTLFESRMVFSGPDAIRDHRTRRPEDTHYIGATSPAIEGSSDAAYLWRPAPFFPPPMYRRCQYAREIGWGVRELSCFTWRNLQSGAQIKRGQIWQAAEDQATHRYQNPWQPAPWVLDYQGPGARARLAWDLARHKGRLQPPSVWAVMIHTPPSHQDKGKRLCKLKSSNQASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SPG6</accession>
    <name>A0A8C2SPG6_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 17">Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase</fullName>
            <shortName evidence="17">GNT-I</shortName>
            <shortName evidence="17">GlcNAc-T I</shortName>
            <ecNumber evidence="14 17">2.4.1.101</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15 17">N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">MGAT1</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13 17">Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + UDP-N-acetyl-alpha-D-glucosamine = N(4)-{beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11456"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="Rhea" id="RHEA-COMP:14368"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:60625"/>
            <dbReference type="EC" id="2.4.1.101"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="17">The cofactor is mostly bound to the substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 17">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Golgi apparatus membrane</location>
            <topology evidence="1 17">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the glycosyltransferase 13 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.101" evidence="14 17"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2SPG6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005003149.1">
        <property type="protein sequence ID" value="ENSCJPP00005001841.1"/>
        <property type="gene ID" value="ENSCJPG00005001888.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063632"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003827">
        <property type="term" value="F:alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.180.20:FF:000001">
        <property type="entry name" value="alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.20">
        <property type="entry name" value="N-Acetylglucosaminyltransferase I, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004139">
        <property type="entry name" value="Glyco_trans_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052261">
        <property type="entry name" value="Glycosyltransferase_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10468:SF0">
        <property type="entry name" value="ALPHA-1,3-MANNOSYL-GLYCOPROTEIN 2-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10468">
        <property type="entry name" value="PROTEIN O-LINKED-MANNOSE BETA-1,2-N-ACETYLGLUCOSAMINYLTRANSFERASE 1/ALPHA-1,3-MANNOSYL-GLYCOPROTEIN 2-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03071">
        <property type="entry name" value="GNT-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 17" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 17" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12 17" id="KW-0464">Manganese</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 17" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="18">
        <location>
            <begin position="13"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU368119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005001841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="385" mass="43720" checksum="38B94C8C3134B695" modified="2022-01-19" version="1">MDPNKAPMAAPRDPAPTPPHPLHPPPTPALLPALPLPEQPLSVTSLPVPDESQLPLPVLVLACDRSSVRRCLDSLLRYRPSATRFPILVSQDCQHPETAAAISSYGDAITRLHPPPHPDPLPVPPEHRKFAGYYKIARHYRWALGHVFNTLHFRAALPLLRSDPSLWCASAWHDNGKERLVDPSRPELLYRTDFFPGLGWLLTSELWAELEPKWPPAFWDDWMRQPEQRRDRACVRPEVSRTVTFGRKGVSHGQFYEQHLRYMLLNRRFVPFTNIDMAYLHRERYDTEWERQLREAQPGELRDLTEINGKTGLNGDSTGSKAAIRIHYHNRESFRAAAKALGIMDDMKAGVPRAAYKGVVTVVFNGRRVYLAPGNGWGGYDPAWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SPI5</accession>
    <name>A0A8C2SPI5_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NIPA like domain containing 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">NIPAL2</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NIPA family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015711622.1">
        <property type="nucleotide sequence ID" value="XM_015856136.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SPI5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005001160.1">
        <property type="protein sequence ID" value="ENSCJPP00005000656.1"/>
        <property type="gene ID" value="ENSCJPG00005000735.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107310449"/>
    <dbReference type="KEGG" id="cjo:107310449"/>
    <dbReference type="CTD" id="79815"/>
    <dbReference type="GeneTree" id="ENSGT00940000159321"/>
    <dbReference type="OrthoDB" id="165382at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF16">
        <property type="entry name" value="NIPA-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005000656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="361" mass="39935" checksum="B28FDCDF3CE4150D" modified="2022-01-19" version="1">MGVLPKSEWASWSMFFEGTFSSPWYNKHKTELLGVLLAAASNLLMSVSLSIQKCAHLRLARQAELKPFYRSELWWCGAALLGLGELCNFTAYGFAPIALIAPLGCVSIIGSAFISVLFLKKTVRAADIVGGSLAVVGMYLLVTFAPNVPQELTARRIQKDLVSWTFLVYVILEIIIFCILLYFYKIKAVKHVVVLLMMVALLASLTVITVKAVASMIMLSAKGKMQLTYPVFYIMLILMAISCVFQVKFLNQAVHLYEARTVVPINFVFCTTSAIISGVIFYQEFQSAAFLSVFMFLFGCLLSFLSVFVIAVNKKEEHLQVPYIDCGCIPGQKLTGKIQPDSYGSCYGTLNNKDDSGKSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SPL7</accession>
    <name>A0A8C2SPL7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Regulator of microtubule dynamics protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Protein FAM82B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">RMDN1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts with microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the RMDN family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015711304.1">
        <property type="nucleotide sequence ID" value="XM_015855818.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SPL7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005000356.1">
        <property type="protein sequence ID" value="ENSCJPP00005000171.1"/>
        <property type="gene ID" value="ENSCJPG00005000253.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107310305"/>
    <dbReference type="KEGG" id="cjo:107310305"/>
    <dbReference type="CTD" id="51115"/>
    <dbReference type="GeneTree" id="ENSGT00950000182992"/>
    <dbReference type="OrthoDB" id="69711at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097431">
        <property type="term" value="C:mitotic spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049039">
        <property type="entry name" value="RMD1-3_a_helical_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056">
        <property type="entry name" value="REGULATOR OF MICROTUBULE DYNAMICS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056:SF16">
        <property type="entry name" value="REGULATOR OF MICROTUBULE DYNAMICS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21033">
        <property type="entry name" value="RMD1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0802">TPR repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005000171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="306" mass="34578" checksum="FDB76B1577CED2DE" modified="2022-01-19" version="1">MAAVVAALALPLRLRPARLGPLLGPLLKEAERGWRGLGWSQVLRKSLRRGVALSTGSFVVYEAFRLVSGHAVVHASSKVAEVIEQADYLYGSGETEKLYRLLVQHKNSEDAELLWRLARASRDLAQLSTTSAEEKKQLAYDSLEYAKRALEKNEANSAAHKWYAICLSDVGDYEGIKVKIGNAFIIKEHFERAIELNPKDATSVHLIGVWCYSFAELPWYQRKIAAMLFATPPTSTYEEALRYFHMAEEADPNFYSKNLLFLGKTYLKLNNKKMALLWLSKAKDYPAHTEEDKQVQKEALELLNSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SPM4</accession>
    <name>A0A8C2SPM4_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Calpain 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">CAPN7</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SPM4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005001243.1">
        <property type="protein sequence ID" value="ENSCJPP00005000704.1"/>
        <property type="gene ID" value="ENSCJPG00005000783.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155892"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090541">
        <property type="term" value="F:MIT domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010634">
        <property type="term" value="P:positive regulation of epithelial cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097264">
        <property type="term" value="P:self proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00044">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02681">
        <property type="entry name" value="MIT_calpain7_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.380">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022682">
        <property type="entry name" value="Calpain_domain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022683">
        <property type="entry name" value="Calpain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036213">
        <property type="entry name" value="Calpain_III_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007330">
        <property type="entry name" value="MIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051297">
        <property type="entry name" value="PalB/RIM13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46143">
        <property type="entry name" value="CALPAIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46143:SF1">
        <property type="entry name" value="CALPAIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01067">
        <property type="entry name" value="Calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04212">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00704">
        <property type="entry name" value="CALPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00720">
        <property type="entry name" value="calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00745">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49758">
        <property type="entry name" value="Calpain large subunit, middle domain (domain III)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="8">
        <location>
            <begin position="258"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="458"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR622684-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005000704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="807" mass="91915" checksum="43A7D667744E79B1" modified="2022-01-19" version="1">MDANALELDAVKFAQLAVQRDQSGRYQEAVFYYKEAAQALIYAGMAGSSLENIQEKINEYLERVQALHSAVQSQNTDPLKSKQQLDLERAHFLVTQAFDEDDKGNVEEAIELYTEAVELCLKTAAETSEAGLQSKLKQLARQALDRAEALKVSMSKSSQKEKSTAARPNQPVRTFFPLGPDFSLNDKPQTIRAVQASESQGQRYTAEEIEVLRKTSKINGIEYVPFMSVDLRERFAFPMPFSDKCGKLPLSPKQKAMFAKWVRPDDITNNPTMIYTVSSFSIKQTIVSDCSFVASLAISAAYERRYNKKLITSIIYPQNKKGEPEYNPCGKYMVKLHINGVPRKVIIDDQLPVDHNGELLCSYSNNKNELWVSLIEKAYMKVMGGYDFPGSNSNIDLHALTGWIPERIAMHSDNQAFDRDSTFRMLYQRFHKGDVLITTATGVMSEEEGEKWGLVPTHAYAVLDIREHKGLRFLQLKNPWSHLRWKGRYSENDTRSWTPDLQKYLNFDPRTAQKIDNGIFWIAWEDLCQYYDVIYLSWNPGLFKESTCIHSTWDAKQGPVKDAYSLANNPQYKLEVQCPQGGAVVWVLLSRHITDKDDFAHNREFITMVVYKTDGKKVYYPADPLPYIDGIRINSPHYLTKIKLTSPGTHTFTLVVSQYEKQNTIHYTIRVYSLCKFTFSKIPTPYTISKRVNGQWKGHSAGGCGNFRDSYKNNPIYQFQLDKSGPLLIELRGPRQYSVGFEIVTVSTVGDPGSYGFQKKSSGDYRCGFCYLEVENILAGVYNIIPTTFLPQQEAGFRIQSEIEVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SPV4</accession>
    <name>A0A8C2SPV4_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">E3 ubiquitin-protein ligase AMFR</fullName>
            <ecNumber evidence="12">2.3.2.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Autocrine motility factor receptor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">AMFR</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-cysteine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-S-ubiquitinyl-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.36"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.36" evidence="12"/>
    <dbReference type="RefSeq" id="XP_015729314.1">
        <property type="nucleotide sequence ID" value="XM_015873828.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SPV4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005003404.1">
        <property type="protein sequence ID" value="ENSCJPP00005001955.1"/>
        <property type="gene ID" value="ENSCJPG00005001559.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107319168"/>
    <dbReference type="CTD" id="267"/>
    <dbReference type="GeneTree" id="ENSGT00940000156482"/>
    <dbReference type="OrthoDB" id="3824970at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036513">
        <property type="term" value="C:Derlin-1 retrotranslocation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904288">
        <property type="term" value="F:BAT3 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990381">
        <property type="term" value="F:ubiquitin-specific protease binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034450">
        <property type="term" value="F:ubiquitin-ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007249">
        <property type="term" value="P:canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038061">
        <property type="term" value="P:non-canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051865">
        <property type="term" value="P:protein autoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044314">
        <property type="term" value="P:protein K27-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070936">
        <property type="term" value="P:protein K48-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000638">
        <property type="term" value="P:regulation of SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd14421">
        <property type="entry name" value="CUE_AMFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16455">
        <property type="entry name" value="RING-H2_AMFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000026">
        <property type="entry name" value="E3 ubiquitin-protein ligase AMFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000149">
        <property type="entry name" value="E3 ubiquitin-protein ligase AMFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040675">
        <property type="entry name" value="AMFR_Ube2g2-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057992">
        <property type="entry name" value="TPR_SYVN1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15067:SF5">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE AMFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15067">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18442">
        <property type="entry name" value="G2BR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25563">
        <property type="entry name" value="TPR_SYVN1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00546">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="18">
        <location>
            <begin position="320"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="CUE" evidence="19">
        <location>
            <begin position="435"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="484"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="572"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="497"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="527"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="543"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00069722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00076914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005001955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="622" mass="71055" checksum="6873AEC1E3C491EA" modified="2022-01-19" version="1">MPLLFLERFPWPSLRTYAALSGLALLAAAFSAQRALSAAGEQRAGGPRALDVAYYLLSDSLCVWVLVNTACCVLMLVAKLIQRAVFGPLRVSERQHLKDKFWNFIFYKFIFIFGVLNVQTVEEVVMWCLWFSGLVFLHLMVQLCKDRFEYLSFSPTTPMSSHIRVLTLLVAMLLSCCGLAVVCGVIGYTHGMHTLAFMAAESLLVTVRTAHVILRYVIHLWDLNHEGTWEGKGTYVYYTDFVMELTLLSLDLMHHIHMLLFGNIWLSMASLVIFMQLRYLFHEVQRRIRRHKNYLRVVGNMEARFAVATPEELAVNNDDCAICWDSMQSARKLPCGHLFHNSCLRSWLEQDTSCPTCRMSLNITDSHHVREDHQRENLDENLVPVAVAEGRPRLNQHNHFFHFDGSRIASWLPSFSVEVMHTTNILGITQASNSQLNAMAHQIQEMFPQVPYHVVLQDLQLTRSVEITTDNILEGRIQVPFPTQRAEAVRPASNSSVERHSADQDDTRTVTQTKRVPLELNSRLEEMGELSEVEAEPSEAEDFEARGSRFSKSADERQRMLVQRKEDLLQQARKRYLNKTSDEDLSTEKPSVPEGTSADPVTLRRRTLAAAAERRLQMQQNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SPW4</accession>
    <name>A0A8C2SPW4_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DNA mismatch repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">MSH2</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15 16">Component of the post-replicative DNA mismatch repair system (MMR).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15 16">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015712430.1">
        <property type="nucleotide sequence ID" value="XM_015856944.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SPW4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005002443.1">
        <property type="protein sequence ID" value="ENSCJPP00005001478.1"/>
        <property type="gene ID" value="ENSCJPG00005001491.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107310883"/>
    <dbReference type="KEGG" id="cjo:107310883"/>
    <dbReference type="CTD" id="4436"/>
    <dbReference type="GeneTree" id="ENSGT00550000074867"/>
    <dbReference type="OrthoDB" id="295033at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032301">
        <property type="term" value="C:MutSalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032302">
        <property type="term" value="C:MutSbeta complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019237">
        <property type="term" value="F:centromeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032181">
        <property type="term" value="F:dinucleotide repeat insertion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032137">
        <property type="term" value="F:guanine/thymine mispair binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032405">
        <property type="term" value="F:MutLalpha complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032357">
        <property type="term" value="F:oxidized purine DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032142">
        <property type="term" value="F:single guanine insertion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032143">
        <property type="term" value="F:single thymine insertion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030183">
        <property type="term" value="P:B cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008340">
        <property type="term" value="P:determination of adult lifespan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006301">
        <property type="term" value="P:DNA damage tolerance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007281">
        <property type="term" value="P:germ cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042771">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045190">
        <property type="term" value="P:isotype switching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043570">
        <property type="term" value="P:maintenance of DNA repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008584">
        <property type="term" value="P:male gonad development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045910">
        <property type="term" value="P:negative regulation of DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043524">
        <property type="term" value="P:negative regulation of neuron apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006119">
        <property type="term" value="P:oxidative phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048298">
        <property type="term" value="P:positive regulation of isotype switching to IgA isotypes"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048304">
        <property type="term" value="P:positive regulation of isotype switching to IgG isotypes"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010224">
        <property type="term" value="P:response to UV-B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010165">
        <property type="term" value="P:response to X-ray"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016446">
        <property type="term" value="P:somatic hypermutation of immunoglobulin genes"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd03285">
        <property type="entry name" value="ABC_MSH2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000003">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000009">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.110:FF:000002">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.10:FF:000003">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000523">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011184">
        <property type="entry name" value="DNA_mismatch_repair_Msh2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032642">
        <property type="entry name" value="Msh2_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003810">
        <property type="entry name" value="PRK05399.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF35">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005813">
        <property type="entry name" value="MSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 15 16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13 15 16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="12 15 16" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="7 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="18">
        <location>
            <begin position="752"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="487"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR005813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005001478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="942" mass="104754" checksum="440466BD6F000C2A" modified="2022-01-19" version="1">MAGGGSMAAEGPREAAWPEGAGAEAGFVRAVLSLPEKPDTTVRFFERGEYYSVHGADARLAARELFRTRAVIRQLAGGTGNQKLESVVLSKMNFESFVRDLLLVRHYRVEVYKNKAGSKSVKENDWYLAYKGSPGNLAQFEEVLFASNDLSMAIGVVGVKLSSADGQRVIGVGYVDTTLRKLSVCEFPDNDQFSNLEALLVQLGPKECVLPGGDTAGEMGKLRQVIQRGGILITDRKKADFTTKDIVQDLSRLLKSRKGEQMNTAALPEMEKQVAVSSLSAVIKFLELLSDDSNFGQFELTTFDLSQYMVLDNAAVQALNLFQSSVENANNTQSLAGLLNKCRTPQGQRLVNQWIKQPLMDKNRIEERLNLVEAFVGDTELRQCLQEDLLRRFPDLNRLAKKFQRQAATLQDCYRMYQAINQLPNVVRALEKHEGAHQMLLLAVFITPLNDIHSDFSKFLEMIETTLDMDKVENHEFLVKASFDPNLTELREKMNELEENMQALLKSAAKELGLEAGKSIKLESNSQLGHHFRITCKEEKVLRNNSKYKITDTQKNGVKFTNSKLSAINEDYIKSREEYEEAQDAIVKEIINIASGYAEPIQTMNDVIAQLDAIVSFAHVSNGAPVPYVRPVILEKGQGRIVLKGARHPCIEVQDEVAFIPNDVTFEKGKQMFHIITGPNMGGKSTYIRQTGVIVLMAQIGCFVPCDSAEITIVDCILARVGAGDSQLKGVSTFMAEMLETASILRTASENSLVIIDELGRGTSTYDGFGLAWAISEYIASKIGAFCMFATHFHELTALADQVPTVNNLHVTALTSDDTLTMLYRVKAGVCDQSFGIHVAELAAFPKHVIESAREKALELEEFQDIGRPKESEGEPAAKKRCREREEGEKIIQDFLCQVKALPLTDMSEEDIKTKLKQLRADVWAKNNSFVNEIISRTKVMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SR19</accession>
    <name>A0A8C2SR19_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">RNF19B</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the RBR family. RNF19 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="4"/>
    <dbReference type="RefSeq" id="XP_015739039.1">
        <property type="nucleotide sequence ID" value="XM_015883553.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SR19"/>
    <dbReference type="Ensembl" id="ENSCJPT00005002312.1">
        <property type="protein sequence ID" value="ENSCJPP00005001379.1"/>
        <property type="gene ID" value="ENSCJPG00005001411.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107323959"/>
    <dbReference type="KEGG" id="cjo:107323959"/>
    <dbReference type="CTD" id="127544"/>
    <dbReference type="GeneTree" id="ENSGT00940000158451"/>
    <dbReference type="OrthoDB" id="1431934at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044194">
        <property type="term" value="C:cytolytic granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042267">
        <property type="term" value="P:natural killer cell mediated cytotoxicity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051865">
        <property type="term" value="P:protein autoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd20355">
        <property type="entry name" value="Rcat_RBR_RNF19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1750:FF:000001">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.20:FF:000004">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000052">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="333"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="386"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="19">
        <location>
            <begin position="100"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="18">
        <location>
            <begin position="104"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="586"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="653"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="54"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="606"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="629"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="667"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00061087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005001379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="730" mass="78331" checksum="3059F776F0ABDF27" modified="2022-01-19" version="1">MGSERDSESPRSSSIHSAAAKCPKPGRRRRLSFQSVFSAAAASAAGGRRRAKADPPPADPPPPPAAPPAPPPPPPPPPPPPPPEEAPVPVPVSAEGSGEEELECPLCLVRQPAENAPRLLSCPHRSCGACLRQYLRIEITESRVNICCPECSERLNPADIRRLLRDSPHLVAKYEEFMLRRCLAADPDCRWCPAPDCGYAVIAYGCASCPKLTCERDGCQTEFCYHCKQIWHPNQTCDMARQQRAQTLRVRTKHTSGLSYGQESGPADDIKPCPRCSAYIIKMNDGSCNHMTCAVCGCEFCWLCMKEISDLHYLSPSGCTFWGKKPWSRKKKILWQLGTLIGAPVGISLIAGIAIPAMVIGIPVYVGRKIHSRYEGKKTSKHKRNLAITGGVTLSVIASPVIAAVSVGIGVPIMLAYVYGVVPISLCRGGGCGVSTANGKGVKIEFDEDDGPITVADAWRALKNPSIGESSIEGLTSVLSTSGSPTDGLSVMQSNYSETASFAALSGGTLSGGVLSGGKGKYSRLEVQADVQKEIFPKDSVSLGAISDNASTRAMAGSIISSYNPQDRECNNMEIQVDIEAKPSHYQLASGSSTEDSLHVHTQMAENEEEEEEEDGEEDEEEEDGEQEQTCKHQSCEQKDCVASKTWDITLAQPESIRSDLESSDSQSDDVPDLTSDECGSPRSHSAAPCPQTPSARGAESPSAHLSHCAHAEGCRLDEMVTLECIEARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SR27</accession>
    <name>A0A8C2SR27_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SR27"/>
    <dbReference type="Ensembl" id="ENSCJPT00005003587.1">
        <property type="protein sequence ID" value="ENSCJPP00005002007.1"/>
        <property type="gene ID" value="ENSCJPG00005002160.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000167808"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03078">
        <property type="entry name" value="GST_N_Metaxin1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005002007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="122" mass="13668" checksum="9CFB61E276254DC5" modified="2022-01-19" version="1">MAAPMELFCWAGGWGLPSVDPDCLAVLTYARFTGAPLKVHRVCNPWKTPLSPIEPHGALLSPITSVPCSSQPCTALTRWRLWRLGYGTYRGWIWDGWSTYRGWIGHSIGHLYGMDKGWIGHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SR77</accession>
    <name>A0A8C2SR77_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Zinc finger CCCH-type containing 12B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ZC3H12B</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZC3H12 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015715568.1">
        <property type="nucleotide sequence ID" value="XM_015860082.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015715570.1">
        <property type="nucleotide sequence ID" value="XM_015860084.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015715571.1">
        <property type="nucleotide sequence ID" value="XM_015860085.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015715572.1">
        <property type="nucleotide sequence ID" value="XM_015860086.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032300494.1">
        <property type="nucleotide sequence ID" value="XM_032444603.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032300495.1">
        <property type="nucleotide sequence ID" value="XM_032444604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SR77"/>
    <dbReference type="Ensembl" id="ENSCJPT00005004848.1">
        <property type="protein sequence ID" value="ENSCJPP00005002597.1"/>
        <property type="gene ID" value="ENSCJPG00005002914.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005004851.1">
        <property type="protein sequence ID" value="ENSCJPP00005002599.1"/>
        <property type="gene ID" value="ENSCJPG00005002914.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107312554"/>
    <dbReference type="KEGG" id="cjo:107312554"/>
    <dbReference type="CTD" id="340554"/>
    <dbReference type="GeneTree" id="ENSGT00940000159316"/>
    <dbReference type="OrthoDB" id="392925at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036464">
        <property type="term" value="C:cytoplasmic ribonucleoprotein granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18729">
        <property type="entry name" value="PIN_Zc3h12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11980:FF:000001">
        <property type="entry name" value="ZC3H12A isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040546">
        <property type="entry name" value="Rege-1_UBA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040757">
        <property type="entry name" value="Regnase_1/ZC3H12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021869">
        <property type="entry name" value="RNase_Zc3h12_NYN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051101">
        <property type="entry name" value="ZC3H12/N4BP1_RNase_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12876">
        <property type="entry name" value="N4BP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12876:SF27">
        <property type="entry name" value="RIBONUCLEASE ZC3H12B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18561">
        <property type="entry name" value="Regnase_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11977">
        <property type="entry name" value="RNase_Zc3h12a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18039">
        <property type="entry name" value="UBA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="12">
        <location>
            <begin position="356"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="10">
        <location>
            <begin position="356"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="148"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="410"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="470"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="487"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005002597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="836" mass="93966" checksum="D1752C2BE7D5ED97" modified="2022-01-19" version="1">MTAWSMVGKLKMEKRHPREERNVEQNAGECSAESEEWTSSESEPEQPYFRSSCSNIPWREKEVSTKPHRPLCRSPCLDRPSFSQSSITQDLKLEECKTNVDKEYQAKMDFALKLGYAGDQIQAVLNKLGADALINDVLAELVRLGNKSESEGQSSASSTTNTLVPRNPCPKEIASPELSLEDEVVDNSDNLRPIVIDGSNVAMSHGNKEGFSCRGIQLAVDWFLEKGHKDITVFVPAWRKEQSRPDAPITDQEILRKLEKEKILVFTPSRRVQGRRVVCYDDRFIVKLAFDSDGIIVSNDNYRDLANEKPEWKKFIEERLLMYSFVNDKFMPPDDPLGRHGPSLENFLRKRPVIPEHKKQPCPYGKKCTYGHKCKYYHPERANQPQRSVADELRISAKLSAVKTMSEGALAKCGTGPSSSKGEISSEVKRIAPKRQSDPSIRSVAVEPEEKLTVARKSEANSVPSLVSALSVPTLPPPKSHAAGALNTRSASSPVPGSSQFTHQKSSLEHMSSVQYPPILVTNSHGTSVSYTDQYPKYESLGDHGYYSLLSDFSNLSISSMHNTDYYGADMDQGMYSRNSSPCPDNCLSHTSNDSYSSYNDLYLGVADASPEDNVKIHRLTSQNRLQPFPHGYHEALNRVQSFGTEEPKSLRKQSVSHLGLHAQHPVIGARSSCPGEYPVPQNIHPSTAQPSRALVMTRMDSISDSRLYESNPTRQRRPPLCREQHASWDPLPCASDPYTYHSYPLSNNLMQPCYEPVMVRSMPEKMEQLWRNPWIGICGEPREQHIIPEHQYQTYKNLCNIFPPSIVLSVMEKNPHMTDAQQLAAMIVAKLRTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SRG3</accession>
    <name>A0A8C2SRG3_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Galactose-3-O-sulfotransferase 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">GAL3ST4</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the galactose-3-O-sulfotransferase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SRG3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005003708.1">
        <property type="protein sequence ID" value="ENSCJPP00005002058.1"/>
        <property type="gene ID" value="ENSCJPG00005002234.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182923"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001733">
        <property type="term" value="F:galactosylceramide sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009101">
        <property type="term" value="P:glycoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009729">
        <property type="entry name" value="Gal-3-0_sulfotransfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14647">
        <property type="entry name" value="GALACTOSE-3-O-SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14647:SF57">
        <property type="entry name" value="GALACTOSE-3-O-SULFOTRANSFERASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06990">
        <property type="entry name" value="Gal-3-0_sulfotr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005002058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="366" mass="40790" checksum="06E9673E51560B12" modified="2022-01-19" version="1">MVPPSPSSLPPINPRVPPSPPAAPPPLPPSDPRGVLKTHKTGAGSVGFNVLHRFGEGRGLRFALPHHYQFRKIPRNLQGRKGEGLQRGGGPIRHHLPPHEVRRVMPPDSFYFSIARDPAAAAESALSYYRSSVPAFRRAPSRSAFLLTPWLYYQPGLKGNHYARNLLWFDFGLPSISPSNMAAVAAAVRGLDAIFALVLLAEYFDESLVLLADALCWPLGAVVTFPHNGRPKGSVLRLGRGDMERLRQWNALDWALYVHFNRSFWARVRRFGLARMEREVTRLRGLREQWAQRCLQGGGPLPAAAILDRNLKPFQPGQGAAAVMGYELRADLGARDRETCERMATPELQYKDRLHRRQFGPNATNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2ST03</accession>
    <name>A0A8C2ST03_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Retinol dehydrogenase 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">RDH5</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015742496.1">
        <property type="nucleotide sequence ID" value="XM_015887010.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2ST03"/>
    <dbReference type="Ensembl" id="ENSCJPT00005005991.1">
        <property type="protein sequence ID" value="ENSCJPP00005003365.1"/>
        <property type="gene ID" value="ENSCJPG00005003563.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107325819"/>
    <dbReference type="KEGG" id="cjo:107325819"/>
    <dbReference type="CTD" id="5959"/>
    <dbReference type="GeneTree" id="ENSGT00940000161168"/>
    <dbReference type="OrthoDB" id="5296at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome LGE22C19W28_E50C23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004745">
        <property type="term" value="F:all-trans-retinol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047044">
        <property type="term" value="F:androstan-3-alpha,17-beta-diol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047023">
        <property type="term" value="F:androsterone dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001523">
        <property type="term" value="P:retinoid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd09805">
        <property type="entry name" value="type2_17beta_HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000074">
        <property type="entry name" value="Retinol dehydrogenase type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313:SF12">
        <property type="entry name" value="RETINOL DEHYDROGENASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005003365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="319" mass="35658" checksum="01D074F19CF9DDF7" modified="2022-01-19" version="1">MWLYLLLAALVWALGWLVRDRRTLPSVKDKHVFITGCDSGFGNLLARRLAQRGFRVLAACLTPQGADGLQRGCAGNLRTTLLDVTRSESIRRAAEWVREEVGEKGLFGLVNNAGVANPIGPTEWMRIEDYKQVMAVNTFGAIEVTLQLLPLLKRARGRVVNTSSVLGRLSANGGGYCVSKYCIEAFSDSLRRDMYHFGVKVSIIEPGYFKTAITNLESIEGSLRQLWDRLAPETQLSYGEEFFHKYLKVQRLIMNIICDADLGKVTRCMEHALGACHPRTRYSAGWDAKLLWLPASYLPACIVDFVLATVLPKPAHRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SUJ4</accession>
    <name>A0A8C2SUJ4_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Prostaglandin F2 receptor inhibitor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">PTGFRN</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015735013.1">
        <property type="nucleotide sequence ID" value="XM_015879527.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SUJ4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005005648.1">
        <property type="protein sequence ID" value="ENSCJPP00005003127.1"/>
        <property type="gene ID" value="ENSCJPG00005003368.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107321987"/>
    <dbReference type="KEGG" id="cjo:107321987"/>
    <dbReference type="CTD" id="5738"/>
    <dbReference type="GeneTree" id="ENSGT00940000158367"/>
    <dbReference type="OrthoDB" id="9873136at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00099">
        <property type="entry name" value="IgV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000191">
        <property type="entry name" value="Immunoglobulin superfamily member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001070">
        <property type="entry name" value="Prostaglandin F2 receptor inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:002026">
        <property type="entry name" value="Prostaglandin F2 receptor inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000854">
        <property type="entry name" value="Prostaglandin F2 receptor negative regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051102">
        <property type="entry name" value="IgSF_V-set/TM_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12207:SF3">
        <property type="entry name" value="PROSTAGLANDIN F2 RECEPTOR NEGATIVE REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12207">
        <property type="entry name" value="V-SET AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034113718" evidence="10">
        <location>
            <begin position="27"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="838"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="13"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="166"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="285"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="413"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="695"/>
            <end position="803"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005003127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="886" mass="99897" checksum="E0C04B845ADCC474" modified="2022-01-19" version="1">MGQRGERAPCTLPLLLLLLLLAFCRGRIVRVPKGPLIRVIGTEVVIPCSVSDYDGPSEQNFDWEFSRGTDFLRIVSTWDSTFTSEEYQKRVGRGDIKLRRSSNDAVELVIRNMQPADQGIYKCSTPSTDATVQGNYDAEVQVKVISDGLSVSGSKARSSTSLKLSEGDSFKLRCSAITTSPEHTHLHVTWQIRSGLSWRDILSLTHEGKFQPGPGYEERYRNGDIRLDTGANDTYQLSVSQASSADGGVYRCLVSEWVRGADSLWQKIQEKSVEIASVEIQRTALDVLISTSNLSVTERDSLDLTCNVTTDRSGIFQAEVTWYFSESPDDSLSDAQVLLSMDHNSVVSDSTLISLSHVDRNSYRLLVRDVDVEDSGYYFCQASVWVPLHNGSWHKVVERISAPVSVVVTALEPDYEVFLNASRTPKFSDDPTELECRITNVQDTEADIRFSVSWYYRQHLLGDDVVSDELLATMDADWTLMLGDRSRERTQNGEIIFFKKAVDTFSLRIQWTSENDRGDYFCVVSAWSRHRNNSWVKSKDVTSASVPILWATQDYTLTVEAVKLKPFFVAGHTFEMTCKVSSKNIKTPRYSVLITAEKPLTDQSNPNGTTRIISLNQDSVVRLEDWTDQTRVDGVVLEKVQENEFRYRMYQTQISDAGLYRCVVTAWSPGGGGMWREAVNGLSNPIQIDFQTSGPVFNVSAYSDNLTIYQGELADLLCIITTDGMTLEPDDMSFDVSWFAVRSFALDREPVLLASMDRRGIVTQSRRNGSSDLSLERISPLEFRLRIHGCEDHDFGNHYCVVTPWVRSATGVWQREPDIRAKPIFLSVKMDVLNAFKYPLLIGIGLATVIGLLSCLIGYCSSRWCCKKEVQETRRERRRLMSMEMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SUM5</accession>
    <name>A0A8C2SUM5_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">U3 small nucleolar RNA-interacting protein 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">RRP9 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">U3 small nucleolar ribonucleoprotein-associated 55 kDa protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">RRP9</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Component of a nucleolar small nuclear ribonucleoprotein particle (snoRNP) thought to participate in the processing and modification of pre-ribosomal RNA (pre-rRNA). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Interacts specifically with the U3 small nucleolar RNA (U3 snoRNA). Binds a sub-fragment of the U3 snoRNA surrounding the B/C motif (3UBC). This association with the U3BC RNA is dependent on the binding of a protein called 15.5K to the box B/C motif. The association of the protein with the U3BC RNA was found to be also dependent on a conserved RNA structure that flanks the box B/C motif. Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat RRP9 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SUM5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005006927.1">
        <property type="protein sequence ID" value="ENSCJPP00005004049.1"/>
        <property type="gene ID" value="ENSCJPG00005004106.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158328"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000143">
        <property type="entry name" value="U3 small nucleolar RNA-interacting protein 2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039241">
        <property type="entry name" value="Rrp9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19865">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19865:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="7 19" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="19">
        <location>
            <begin position="166"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="19">
        <location>
            <begin position="219"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="19">
        <location>
            <begin position="261"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="19">
        <location>
            <begin position="303"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="19">
        <location>
            <begin position="344"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="20">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00055322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00065513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00074377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00076054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00077445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005004049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="504" mass="55106" checksum="5ED4D9BBF744407E" modified="2022-01-19" version="1">MAAAGRRARAARRRRRPQVSVSAGSGRAGRFRERFGADGAVASPQGPGAEGKSRPPPPRSRDEEVSSEEEAESAAARRRRDEAAAEEELEETPQEKKLRLAKLYLEELRRLEEERADEEEDEGAAGFPGDLVGERLKEDVLEQQGRLRRPAAQDVCPPAPAAIRVLRGHQHSVTCLVVSPDDKFIFSAAKDGSVIKWEVESGKRLCVVPGGKKGVEGQPMGHTAHVLCIAISSDGKYLATGDRDKLILIWEAATCKRLYTFTGHRDAVSGLSFRKGTYQLYSASHDRSVKVWNVEENAYVETLFGHQDIITGMDSLSRECCVTSGGRDGTVRFWKIPEESQLIFYGHQGSIDCIQLINEEHMVSGADDGSVALWGLAKKKPLALVRQSHGTQGSAQDLQQPYWVSAVAALLNSDLVATGSHSGCVKLWKCGEGFQKLEPICDIPLAGFVNSLKFSSAGDFLVAGIGQEHRLGRWWRIKEAKNSICIIPLKCRAVVPGPMADENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SWH6</accession>
    <name>A0A8C2SWH6_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">RIC3 acetylcholine receptor chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">RIC3</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ric-3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015719600.1">
        <property type="nucleotide sequence ID" value="XM_015864114.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SWH6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005007985.1">
        <property type="protein sequence ID" value="ENSCJPP00005004856.1"/>
        <property type="gene ID" value="ENSCJPG00005004706.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107314649"/>
    <dbReference type="KEGG" id="cjo:107314649"/>
    <dbReference type="CTD" id="79608"/>
    <dbReference type="GeneTree" id="ENSGT00440000034107"/>
    <dbReference type="OrthoDB" id="9938788at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000010">
        <property type="term" value="P:positive regulation of protein localization to cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034394">
        <property type="term" value="P:protein localization to cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065003">
        <property type="term" value="P:protein-containing complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007271">
        <property type="term" value="P:synaptic transmission, cholinergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026160">
        <property type="entry name" value="Ric3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032763">
        <property type="entry name" value="RIC3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21723:SF3">
        <property type="entry name" value="PROTEIN RIC-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21723">
        <property type="entry name" value="RESISTANCE TO INHIBITORS OF CHOLINESTERASE PROTEIN 3 RIC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15361">
        <property type="entry name" value="RIC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034055290" evidence="10">
        <location>
            <begin position="30"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Resistance to inhibitors of cholinesterase protein 3 N-terminal" evidence="11">
        <location>
            <begin position="15"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="31"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="343"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="142"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="344"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="379"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF15361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005004856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="388" mass="42819" checksum="31DA6EC3EABCC70A" modified="2022-01-19" version="1">MAPSTCRRVAVVSCLVLCVSFLLPRTFLSRGGGGSQEPGAAAPEGKLSRFPPRMHYQGTPDSRAAPPFPRSHLAEAVAKAKAGGGGGSAGGTGRGLVGQIIPIYGFGIFLYILYILFKLASKGKTTPGERKCPPAAPGNLKRKITDYELTQLQEKLRETEEAMEKLINRVGPHCDRAQNVTSDQEKRLLQQLREITRVMKEGKFIDGISPEKEAEEAPYMEDWEGYPEETYPIYDNSDCFKRKQDTILVDYPDLSQPSAEELAERMEGMEDEEYLCNEALLSDLTVGRDSHDSVQKKDEVAGISEGERDLQHSQSTEGCCYCYEEEDDPAIIAENAVFHSESCSEAEEATPEDLSMEFDNENAALKKQKASDSDNTGTLRKRNTKGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SWM1</accession>
    <name>A0A8C2SWM1_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SWM1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005005641.1">
        <property type="protein sequence ID" value="ENSCJPP00005003124.1"/>
        <property type="gene ID" value="ENSCJPG00005003361.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000290220"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005003124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="344" mass="37850" checksum="099941A816D97F76" modified="2022-01-19" version="1">MGRPYGVPLWGATAESRSRRPTPAGGGGQRGGVPEPTMDPKVEPQTVGPQREGPQSGTPKRGTPRMGPQRVEPLKWDPKEGPQEWDPKEWDPKEGPQHRTLIVGTSKVGPQEWDPKKRDPKSGTPKWDPKRRTPKRGTQRVGPQKWDPKRETSKSGTPKVGHQEWDPKRGTPKVGPQSGTPIVGPQRVGPQREGPKGWDPKKRDPRSGTPKEGPQRAGPQREGPKGWDPKVGPQSGTPNEGPPKWDTKSGTPKEGPQKRGIQRVEPQYGTPKWNPKRETSKSGTSKERDPKSGTPKWDPKRETSKSGTSKEKDPKSGTPKWDPNSGTPKSGTPKRDPKRGTPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SXP7</accession>
    <name>A0A8C2SXP7_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Thyroid hormone-inducible hepatic protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC107308554</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SPOT14 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015708008.1">
        <property type="nucleotide sequence ID" value="XM_015852522.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SXP7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005007610.1">
        <property type="protein sequence ID" value="ENSCJPP00005004569.1"/>
        <property type="gene ID" value="ENSCJPG00005004501.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107308554"/>
    <dbReference type="KEGG" id="cjo:107308554"/>
    <dbReference type="GeneTree" id="ENSGT00500000044890"/>
    <dbReference type="OrthoDB" id="9450804at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046890">
        <property type="term" value="P:regulation of lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053719">
        <property type="entry name" value="Lipogen_MT_Stabilize_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009786">
        <property type="entry name" value="Spot_14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14315">
        <property type="entry name" value="SPOT14 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14315:SF18">
        <property type="entry name" value="THYROID HORMONE-INDUCIBLE HEPATIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07084">
        <property type="entry name" value="Spot_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="58"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005004569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="129" mass="14222" checksum="8A8FC34626CBFFE2" modified="2022-01-19" version="1">MEQYFSATQKMEQEVMFPSLLRGVFPQDGADPATSGSADLYERYQLLKAIKPMVERGLASVTDQSPTSNDDANAAPDDGIDGNLEERLSHHMNGLQQVLTDLTKNTKALTRRYSQILEEINLGEGQSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SZ60</accession>
    <name>A0A8C2SZ60_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Hemoglobin subunit beta-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC107308586</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the globin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015708054.1">
        <property type="nucleotide sequence ID" value="XM_015852568.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SZ60"/>
    <dbReference type="Ensembl" id="ENSCJPT00005009537.1">
        <property type="protein sequence ID" value="ENSCJPP00005005990.1"/>
        <property type="gene ID" value="ENSCJPG00005005649.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107308586"/>
    <dbReference type="KEGG" id="cjo:107308586"/>
    <dbReference type="GeneTree" id="ENSGT00940000157809"/>
    <dbReference type="OrthoDB" id="9886081at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072562">
        <property type="term" value="C:blood microparticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031838">
        <property type="term" value="C:haptoglobin-hemoglobin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005833">
        <property type="term" value="C:hemoglobin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031720">
        <property type="term" value="F:haptoglobin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043177">
        <property type="term" value="F:organic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08925">
        <property type="entry name" value="Hb-beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.490.10:FF:000001">
        <property type="entry name" value="Hemoglobin subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002337">
        <property type="entry name" value="Hemoglobin_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050056">
        <property type="entry name" value="Hemoglobin_oxygen_transport"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11442">
        <property type="entry name" value="HEMOGLOBIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11442:SF7">
        <property type="entry name" value="HEMOGLOBIN SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00814">
        <property type="entry name" value="BETAHAEM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Globin" evidence="8">
        <location>
            <begin position="3"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005005990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="147" mass="16351" checksum="AF635BD1076C4241" modified="2022-01-19" version="1">MVHWSAEEKQLITGLWGKVNVAECGAEALARLLIVYPWTQRFFASFGNLSSPTAITGNPMVRAHGKKVLTSFGEAVKNLDNIKKSFAQLSKLHCDKLHVDPENFRLLGDILIVVLASHFGKDFTPACQAAWQKMVRVVAHALAHEYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SZQ3</accession>
    <name>A0A8C2SZQ3_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cilia and flagella associated protein 298</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">CFAP298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CFAP298 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015736851.1">
        <property type="nucleotide sequence ID" value="XM_015881365.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SZQ3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005008830.1">
        <property type="protein sequence ID" value="ENSCJPP00005005438.1"/>
        <property type="gene ID" value="ENSCJPG00005005211.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107322851"/>
    <dbReference type="KEGG" id="cjo:107322851"/>
    <dbReference type="CTD" id="56683"/>
    <dbReference type="GeneTree" id="ENSGT00390000006278"/>
    <dbReference type="OrthoDB" id="276065at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003352">
        <property type="term" value="P:regulation of cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021298">
        <property type="entry name" value="CFAP298"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13238:SF0">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13238">
        <property type="entry name" value="PROTEIN C21ORF59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11069">
        <property type="entry name" value="CFAP298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005005438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="290" mass="33130" checksum="77A3DEFCC9FC074A" modified="2022-01-19" version="1">MVRLHVKRGDESQFLLEAACSARIAELAPLVARIYNGRLKVQRLCSEMQELAEHGVYLPLNMQGLTDEQIEELKLKDEWAEKCVPSGGSVFKKDEIGRRNGHAPNEKMQQVIRKTIEEAKALISKKQVQANVCLNLDMVKDALDQLRGAVMIVYPMGLPPHDPVRMELEDKEDLSGTHAGLEVIEESEAQLWWAGKELKETKLLSDYVGRNEKTTIIVKIQKKGQGAPGREPLISHEEQKQMMLYYHKKQEELKKLEEDDDDSFLNAEWADSHALKRQFHGVKDIKWGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T077</accession>
    <name>A0A8C2T077_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Vesicle-associated membrane protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC107317966</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the synaptobrevin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T077"/>
    <dbReference type="Ensembl" id="ENSCJPT00005009502.1">
        <property type="protein sequence ID" value="ENSCJPP00005005976.1"/>
        <property type="gene ID" value="ENSCJPG00005005627.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158370"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15870">
        <property type="entry name" value="R-SNARE_VAMP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016444">
        <property type="entry name" value="Synaptobrevin/VAMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45701">
        <property type="entry name" value="SYNAPTOBREVIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00417">
        <property type="entry name" value="SYNAPTOBREVIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="5">
        <location>
            <begin position="29"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005005976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="120" mass="13228" checksum="3507D2BE0213EFDE" modified="2022-01-19" version="1">MSAPAPTQGPTGAGAAGPPPATNVSSNKRLQQTQAQVDEVVDIMRMNVDKVLERDQKLSELDNRADALQAGASQFETSAAKLKRKYWWKNCKFISPLEKMKKEDLAQLCSYQPTISVFLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T1W3</accession>
    <name>A0A8C2T1W3_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">R-spondin-2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Roof plate-specific spondin-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">RSPO4</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the R-spondin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T1W3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005009837.1">
        <property type="protein sequence ID" value="ENSCJPP00005006219.1"/>
        <property type="gene ID" value="ENSCJPG00005005835.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160937"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000028">
        <property type="entry name" value="R-spondin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.220.10:FF:000012">
        <property type="entry name" value="R-spondin 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.220.10">
        <property type="entry name" value="Hormone Receptor, Insulin-like Growth Factor Receptor 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051514">
        <property type="entry name" value="R-spondin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043601">
        <property type="entry name" value="Rspo_Fu-CRD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46987">
        <property type="entry name" value="NEUROHYPOPHYSIAL HORMONES, N-TERMINAL DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46987:SF6">
        <property type="entry name" value="R-SPONDIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15913">
        <property type="entry name" value="Furin-like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00261">
        <property type="entry name" value="FU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0358">Heparin-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="8 14" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034108119" description="R-spondin-2" evidence="14">
        <location>
            <begin position="21"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="R-spondin Fu-CRD" evidence="15">
        <location>
            <begin position="203"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="21"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="363"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="372"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00074432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00075541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF15913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="391" mass="42694" checksum="1B30B33609EECBB3" modified="2022-01-19" version="1">MHGMARLGIVWLIPARLGTARHTRSSCRTPRPSPPTGAGAGPSRGGATRLSPPRRAGGFSVPPPGRDGSGTDGGRRDSRTAGRSDPGRGSAARPSPLLPVPRGDIFPSLYFSGGEKRGAASGPKGRAHRRCPALTAPCPHSAVPCPGRCCELRSDGLSSSLPFTPPAQMQWIIFMLLLFISSMEMLSQNRWKKQVSAGLLENCTGCVLCSEENGCITCHHRLFLLIWRDGIRQYGVCVHTCPPGYFGVRGLEVNRCTKCRSPSCESCFSKDFCMKCKDKFYLHKGQCFRQCPPSTAARPDTRECQETCEPGPWSEWSACTHEGRTCGCKWGLETRVREVPGTPREEGAACPALLESRKCRLRKHCPGEKTKPKTKGKKRQKKQRTEQDAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T235</accession>
    <name>A0A8C2T235_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized family 31 glucosidase KIAA1161-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC107305735</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015703732.1">
        <property type="nucleotide sequence ID" value="XM_015848246.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T235"/>
    <dbReference type="Ensembl" id="ENSCJPT00005009446.1">
        <property type="protein sequence ID" value="ENSCJPP00005005925.1"/>
        <property type="gene ID" value="ENSCJPG00005005601.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107305735"/>
    <dbReference type="KEGG" id="cjo:107305735"/>
    <dbReference type="GeneTree" id="ENSGT00940000161008"/>
    <dbReference type="OrthoDB" id="10070917at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome Z"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048741">
        <property type="term" value="P:skeletal muscle fiber development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06592">
        <property type="entry name" value="GH31_NET37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000037">
        <property type="entry name" value="Putative family 31 glucosidase KIAA1161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050985">
        <property type="entry name" value="Alpha-glycosidase_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43053">
        <property type="entry name" value="GLYCOSIDASE FAMILY 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43053:SF4">
        <property type="entry name" value="MYOGENESIS-REGULATING GLYCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="7">
        <location>
            <begin position="302"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="7">
        <location>
            <begin position="514"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="8">
        <location>
            <begin position="614"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005005925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="698" mass="81072" checksum="1CF8BE27E2E4DB06" modified="2022-01-19" version="1">MESQITHRKEKHGNTHKREEKEIHWTRGLTLVKQKPSKELRPMLGAVTLGLILFITAVVAWCYYTVSLRKAEQLKTELMDLRADGFVIRNQHGEVVFRLAFRSGSLDLESCSKEGEILSCTRSHRGPLNFFIQTVKPKDTVMCYRVRWEELAAGPAVEHTMFWEDAHWYGGSEMSTQHWPIRLAGYQEPVPYVTSDVYSFRDSFGGILERYWLSSKAAAIKINDSVPFHLGFNATERSLFFQARYKDSPYKPPPGQQPFPELSYRVCVGSDVTSIHKYMVRRYFNKPSKIPAENVFCYPIWSTWALYKKDINQDKVLHFARNLKKYHFNCSHIEIDDMYTQAYGDFDFDTVKFPNVTEMFAKLREDGFKVTLWIHPFIHVDSSNFGVGIERQLFIKEPSGRLPAMVEWWNGIGAILDFTNPAARDWFQSHLRQLRHKYGISSFKFDAGETSYLPKQFSTFRPLSDPSIWSRRYTEMAIPFYELAEVRVGYQSQNISCFFRIIDRDSVWGYELGLKSLIPTVLTISMLGYPFVLPDMIGGNFLPNKTDGAVEIPDRELYIRWLELSAFMPSMQFSIPPWLYDKEVVEIAQKFTELHESLVAPLLLELAREVTDTGDPIIRPIWWISPHDEATHRIDSQFLIGDTLMVAPVLEMGKQERDIYLPVGKWHSYKGELFEKTPVLLTDYPVDLDEVAYFLWVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T276</accession>
    <name>A0A8C2T276_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Heteroous nuclear ribonucleoprotein M</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">HNRNPM</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T276"/>
    <dbReference type="Ensembl" id="ENSCJPT00005010217.1">
        <property type="protein sequence ID" value="ENSCJPP00005006472.1"/>
        <property type="gene ID" value="ENSCJPG00005006060.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154595"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042382">
        <property type="term" value="C:paraspeckles"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000380">
        <property type="term" value="P:alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd12659">
        <property type="entry name" value="RRM2_hnRNPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12661">
        <property type="entry name" value="RRM3_hnRNPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000033">
        <property type="entry name" value="heterogeneous nuclear ribonucleoprotein M isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000034">
        <property type="entry name" value="heterogeneous nuclear ribonucleoprotein M isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024666">
        <property type="entry name" value="HnRNP_M_PY-NLS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034990">
        <property type="entry name" value="hnRNPM_RRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF6">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11532">
        <property type="entry name" value="HnRNP_M_NLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="77"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="206"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="628"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="42"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="705" mass="75621" checksum="B8FFA9DB383DF0DD" modified="2022-01-19" version="1">MAAAAAVAAATESAGGKMEEPPAAAAAPPPPNGAGGAGDAPVKSEGERPSQNEKRKEKSVKRGGNRFEPYANPAKRYRAFITNIPFDVKWQSLKDLVKEKVGEVTYVELLMDAEGNVVEFKMEESMKKAAEVLNKHSLGGRPLKVKEDPDGEHARRAMQKVMAAGGMGIGPGPGGPGMINIPPSILNNPNIPNEIIHALQAGRLGSTVFVANLDYKVGWKKLKEVFSMAGAVVRADILEDKDGKSRGIGTVTFEQAIEAVQAISMFNGQLLFDRPMHVKMDERAFPKGDFFPPERPQQLPRMGMEGMGFGMNKMGGMEGPFGGMENIGRFPAGMNMGRMSEMDRAMGGGFEREFGRNEMGMSRSFGETLERGIGGGNASIPGIERMAPGIDRMGSGIERIPSGMGHGMERVGSEIDRMGLVLDRMSSNVDRIGTGIDRMAPLGIDHIAPNIERMGPAIERMGSGIERMGSGIGFGIERMGAAIDRVGTTMDRMGSGVERMGSGMDRMGIGMERMVPAGMGTGMGQVIERMPAGLDRIGATPMERIGIDRMGAASMERMGLERIGATNMERMGPAMGQGMGAGIDRMGLAMGSNFERTMEMERGNFAGNFAGSLGGTGGPAAGVARKACQIFVRNLPFDFTWKMLKDKFNECGHVLYADIKMENGKSKGCGVVRFESPEVAERACRMMNGIQLRGREIDVRIDRNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T2Q2</accession>
    <name>A0A8C2T2Q2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ADP-ribosylation factor-like protein 14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">ADP-ribosylation factor 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ARF6</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">GTPase that recruits MYO1E to MHC class II-containing vesicles via the effector protein ARL14EP and hence controls the movement of these vesicles along the actin cytoskeleton in dendritic cells.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Interacts with ARL14EP.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T2Q2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005011731.1">
        <property type="protein sequence ID" value="ENSCJPP00005007598.1"/>
        <property type="gene ID" value="ENSCJPG00005006959.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156593"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032154">
        <property type="term" value="C:cleavage furrow"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031527">
        <property type="term" value="C:filopodium membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090543">
        <property type="term" value="C:Flemming body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001726">
        <property type="term" value="C:ruffle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019003">
        <property type="term" value="F:GDP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031996">
        <property type="term" value="F:thioesterase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030866">
        <property type="term" value="P:cortical actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902217">
        <property type="term" value="P:erythrocyte apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090162">
        <property type="term" value="P:establishment of epithelial cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097284">
        <property type="term" value="P:hepatocyte apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001889">
        <property type="term" value="P:liver development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000009">
        <property type="term" value="P:negative regulation of protein localization to cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030838">
        <property type="term" value="P:positive regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120183">
        <property type="term" value="P:positive regulation of focal adhesion disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051549">
        <property type="term" value="P:positive regulation of keratinocyte migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903438">
        <property type="term" value="P:positive regulation of mitotic cytokinetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010976">
        <property type="term" value="P:positive regulation of neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903078">
        <property type="term" value="P:positive regulation of protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050714">
        <property type="term" value="P:positive regulation of protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034394">
        <property type="term" value="P:protein localization to cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905345">
        <property type="term" value="P:protein localization to cleavage furrow"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036010">
        <property type="term" value="P:protein localization to endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060998">
        <property type="term" value="P:regulation of dendritic spine development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051489">
        <property type="term" value="P:regulation of filopodium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035020">
        <property type="term" value="P:regulation of Rac protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097178">
        <property type="term" value="P:ruffle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000412">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 8 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="20"/>
            <end position="27"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="122"/>
            <end position="125"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00054077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00072405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00077764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005007598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="154" mass="17620" checksum="FB75188F5E601767" modified="2022-01-19" version="1">MGKVLSKIFGNKEMRILMLGLDAAGKTTILYKLKLGQSVTTIPTVGFNVETVTYKNVKFNVWDVGGQDKIRPLWRHYYTGTQGLIFVVDCADRDRIDEARQELHRIINDREMRDAIILIFANKQDLPDAMKPHEIQEKLEGRKNQRCESSAEPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T3P8</accession>
    <name>A0A8C2T3P8_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein Abitram</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Actin-binding transcription modulator</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Protein Simiate</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ABITRAM</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Dendrite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cell projection</location>
            <location evidence="4">Growth cone</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Lamellipodium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ABITRAM family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015710643.1">
        <property type="nucleotide sequence ID" value="XM_015855157.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T3P8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005011773.1">
        <property type="protein sequence ID" value="ENSCJPP00005007639.1"/>
        <property type="gene ID" value="ENSCJPG00005006981.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107309955"/>
    <dbReference type="KEGG" id="cjo:107309955"/>
    <dbReference type="CTD" id="54942"/>
    <dbReference type="GeneTree" id="ENSGT00450000040303"/>
    <dbReference type="OrthoDB" id="48130at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032433">
        <property type="term" value="C:filopodium tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030426">
        <property type="term" value="C:growth cone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003785">
        <property type="term" value="F:actin monomer binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048813">
        <property type="term" value="P:dendrite morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051489">
        <property type="term" value="P:regulation of filopodium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000048">
        <property type="entry name" value="Protein Abitram"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039169">
        <property type="entry name" value="Abitram"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13651">
        <property type="entry name" value="PROTEIN ABITRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13651:SF0">
        <property type="entry name" value="PROTEIN ABITRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005007639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="173" mass="19201" checksum="5B49258E39B1B219" modified="2022-01-19" version="1">MAACEALGAARYFTRWYKADVKGRPCEDFCVLQHSNRICVITLAEAHPLLQHGKTITSINYQISPNCSRLQNKVSGKSKRGAQFLTELAPLCRIASSDGEEYTIYSCIRGRLIEVNENILSNPALLQEKPSTEGYIAVVLPKFEESKSVTQGLLTPEEYKEVLSKRQNSSSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T3Z1</accession>
    <name>A0A8C2T3Z1_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Glucosaminyl (N-acetyl) transferase family member 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">GCNT7</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the glycosyltransferase 14 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T3Z1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005012269.1">
        <property type="protein sequence ID" value="ENSCJPP00005008013.1"/>
        <property type="gene ID" value="ENSCJPG00005007252.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160402"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008375">
        <property type="term" value="F:acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003406">
        <property type="entry name" value="Glyco_trans_14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19297:SF178">
        <property type="entry name" value="BETA-1,3-GALACTOSYL-O-GLYCOSYL-GLYCOPROTEIN BETA-1,6-N-ACETYLGLUCOSAMINYLTRANSFERASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19297">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 14 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02485">
        <property type="entry name" value="Branch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="406"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="429"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005008013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="441" mass="50147" checksum="CE5C7D02AA06A7E9" modified="2022-01-19" version="1">MNPLDATKSGFLLCIAVCTFICTFIYLKDSLSTEPDEQKFSTNRAECGFYPDELCSALFMGKTAALKIGSICQNTYRPAALSCVQTSCNCSTVLKALHFITRPLSDEEGSFSLAYIITIHKELEMFVKLLRAIYMPQNIYCIHVDEKSPSDYKAAVQNIVNCFENIFISSKRENVVYGGFSRLQADINCMRDLVHSKIQWNYVINLCGQDYPIKTNKDIIKYIKSKWNGKNMTPGVVQPLHMKHRTQVSYREYVRSGMSYVYPTKNAKTKPPYNLTIYFGSAYYILTKEFVEFTLTDARAKGLLEWSRDTYSPDEHYWVTLNRLHDAPGATPNADWEGNIRAIKWKDQEGTAHKGCKGNVSFYQELQLHSLLIMYYALIAINECASLVTHSILKLSYKTATQPTLLYPTQKPSDTLLQRPPQYPHNDHPSPSCNTSINSTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T4P4</accession>
    <name>A0A8C2T4P4_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Neurophysin 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC107314092</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the vasopressin/oxytocin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015718465.1">
        <property type="nucleotide sequence ID" value="XM_015862979.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T4P4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005012853.1">
        <property type="protein sequence ID" value="ENSCJPP00005008490.1"/>
        <property type="gene ID" value="ENSCJPG00005007570.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107314092"/>
    <dbReference type="KEGG" id="cjo:107314092"/>
    <dbReference type="GeneTree" id="ENSGT00390000004511"/>
    <dbReference type="OrthoDB" id="10056056at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030141">
        <property type="term" value="C:secretory granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005185">
        <property type="term" value="F:neurohypophyseal hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031894">
        <property type="term" value="F:V1A vasopressin receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.9.10:FF:000001">
        <property type="entry name" value="oxytocin-neurophysin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.9.10">
        <property type="entry name" value="Neurohypophysial hormone domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000981">
        <property type="entry name" value="Neurhyp_horm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036387">
        <property type="entry name" value="Neurhyp_horm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022423">
        <property type="entry name" value="Neurohypophysial_hormone_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11681">
        <property type="entry name" value="NEUROPHYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11681:SF9">
        <property type="entry name" value="VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00220">
        <property type="entry name" value="Hormone_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00184">
        <property type="entry name" value="Hormone_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001815">
        <property type="entry name" value="Nonapeptide_hormone_precursor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00831">
        <property type="entry name" value="NEUROPHYSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00003">
        <property type="entry name" value="NH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49606">
        <property type="entry name" value="Neurophysin II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00264">
        <property type="entry name" value="NEUROHYPOPHYS_HORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0027">Amidation</keyword>
    <keyword evidence="4" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="6 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034344071" evidence="8">
        <location>
            <begin position="20"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="20"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="41"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="59"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="92"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="106"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001815-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005008490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="124" mass="13105" checksum="3675461C2C3C491A" modified="2022-01-19" version="1">MSYKALTVCLLGLLALSSACYIQNCPIGGKRALPDMDIRKCLPCGPRNKGHCFGPNICCGEELGCYLGTSETLRCQEENFLPTPCESGRKACGEDGASCAAPGICCSSEGCVFDSSCNQEMLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T773</accession>
    <name>A0A8C2T773_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dynein axonemal intermediate chain 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">DNAI3</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T773"/>
    <dbReference type="Ensembl" id="ENSCJPT00005014161.1">
        <property type="protein sequence ID" value="ENSCJPP00005009484.1"/>
        <property type="gene ID" value="ENSCJPG00005008321.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156924"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036156">
        <property type="term" value="C:inner dynein arm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071933">
        <property type="term" value="F:Arp2/3 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045503">
        <property type="term" value="F:dynein light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060294">
        <property type="term" value="P:cilium movement involved in cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036159">
        <property type="term" value="P:inner dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034316">
        <property type="term" value="P:negative regulation of Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030336">
        <property type="term" value="P:negative regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045669">
        <property type="term" value="P:positive regulation of osteoblast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050687">
        <property type="entry name" value="Dynein_IC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442:SF5">
        <property type="entry name" value="DYNEIN AXONEMAL INTERMEDIATE CHAIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442">
        <property type="entry name" value="DYNEIN INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="600"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="143"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="601"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005009484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="836" mass="95143" checksum="015DFAFE4B12546A" modified="2022-01-19" version="1">MPKSPKSGKTTPKSPKASAKKQKGGKDKQPEKKDEAELSMAAIGHPEIFPLVFTTKTQEIFNCRVDEDVTEENCFKLIKKDDIIQDLKTRAAISDFHPIKNTILEYPGEELLIVFDANFQYGQSFYLVASEEAKENLLKPPETAEEMGSEEEEETPEAYKHPVSKPWVSLGSEKEVEEESVKDRVKKIKYMFSRGHGMFGAPITFTDRNASDVKDSYIECTSYQDKTFTIKLLEKDMGVQMVPILKEASTQTEWTYPKNATTQYFPRELSNEEKEEILSSEKLKEFFTSVCLRMEIALQQNEIMNAFSDDWKDLDDDLSKSDICFKEYQTFTDLHHLKDKSISCVCWHPTIYGIIAESAAKQPSKKEKTKTQQDSVIIFWSLFDPIQPQIILECLEGVYCFQFSPSDPNIIAGGCYSGQVVLWDISRYEEKLQNAKNVTVGMERTIVNMSSVSLLNLLEDNDMSELLSMEGKESDKGQNLVRCFASSSVHHSHEKKITDIHWLPDNFEINRMGETFENRAGICVQLVTCSPDSLILFWDVRDTKLPTYPSPEDEENDFSMLTEASNDPGLVWKPLMKISLCDKDEENNVKCSPTKISLNEQHYRTKTTDKEQSPHKPQALKERPYAQMSVSLNKTLNAIESVSNNFLVGTEDGDIIYSDWEMKTKNDMEKTGEKCTVHKEAVNTVQRSPFFKDIILSVGGGNFAIWKEGVTNGPILQSNCTSQRYTAGHWSLTRPGVFYTATDDGSICIWDLLKETQKPSHIQNISKLAITCISLRIASPKQQFVAVSDDSGVLHILEIHRKLMYPSSNEQANILSYFERRVQNLKNHKKDQEAEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T7A9</accession>
    <name>A0A8C2T7A9_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Poly [ADP-ribose] polymerase</fullName>
            <shortName evidence="10">PARP</shortName>
            <ecNumber evidence="10">2.4.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">PARP6</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-aspartyl-[protein] + NAD(+) = 4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:54424"/>
            <dbReference type="Rhea" id="RHEA-COMP:9867"/>
            <dbReference type="Rhea" id="RHEA-COMP:13832"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29961"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:138102"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-cysteinyl-[protein] + NAD(+) = S-(ADP-D-ribosyl)-L-cysteinyl-[protein] + nicotinamide + H(+)</text>
            <dbReference type="Rhea" id="RHEA:56612"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:14624"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:140607"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the ARTD/PARP family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.-" evidence="10"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2T7A9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005012666.1">
        <property type="protein sequence ID" value="ENSCJPP00005008326.1"/>
        <property type="gene ID" value="ENSCJPG00005007424.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183129"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140806">
        <property type="term" value="F:NAD+-protein-aspartate ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140803">
        <property type="term" value="F:NAD+-protein-cysteine ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070213">
        <property type="term" value="P:protein auto-ADP-ribosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01341">
        <property type="entry name" value="ADP_ribosyl"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.228.10:FF:000032">
        <property type="entry name" value="Poly [ADP-ribose] polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051838">
        <property type="entry name" value="ARTD_PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21328">
        <property type="entry name" value="POLY ADP-RIBOSE POLYMERASE FAMILY, MEMBER PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51059">
        <property type="entry name" value="PARP_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0013">ADP-ribosylation</keyword>
    <keyword evidence="2 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 10" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PARP catalytic" evidence="11">
        <location>
            <begin position="335"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00052566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005008326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="566" mass="63732" checksum="5421BACA1CF53D82" modified="2022-01-19" version="1">MPCKPGQYWTDDDSDGDNESEEFLYGVQGTCAADLYRHPQLDADIEAVKEIYSENAVSVREYGTIDDVDIDLHVNISFLDEEVATAWKVLRTEPIVLRLRFSLSQYLDGPEPSIEVFQPSNKEGFGLGLQLKKILGMFTSQQWKHLSNDFLKTQQEKRHSWFKTSGTIKKFRAGLSIFSPIPKSPSFPVIPDSVLKGKLGAPEVRVNRLMNRSISCTVKNPKGEVFGYTPSTQAGVAPFNILVGGHCKNVPTLEYGFLVQIMKYAEQRIPTLNEYCVVCDEQHVFQNGSMLKPAVCTRELCVFSFYTLGVMSGAAEEVATGAEVHGDLIPPWWTPMTPKHLPSTPSVMSIREMTQGSYLEIKKQMDKLDPLQLKFMHTSHQFLLLSSPPAKEARFRTAKKLYGSTFAFHGSHIENWHSILRNGLVNASYTKLQLHGAAYGKGIYLSPISSISFGYSGMGKGQHRMPSKDELVQRYNRMNTIPQTRSIQSRFLQSRNLNCIALCEVITSKDLQKHGNIWVCPVSDHVCTRFFFVYEDGQVGDANINTQDPKIQKEIMRVIGTQVYTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T7M0</accession>
    <name>A0A8C2T7M0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">T-complex protein 1 subunit eta</fullName>
            <shortName evidence="15">TCP-1-eta</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 15">CCT-eta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">CCT7</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis.</text>
    </comment>
    <comment type="function">
        <text evidence="15">Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the chaperonin-containing T-complex (TRiC), a hexadecamer composed of two identical back-to-back stacked rings enclosing a protein folding chamber. Each ring is made up of eight different subunits: TCP1/CCT1, CCT2, CCT3, CCT4, CCT5, CCT6A/CCT6, CCT7, CCT8.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Heterooligomeric complex that forms two stacked rings.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015718489.1">
        <property type="nucleotide sequence ID" value="XM_015863003.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T7M0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005013297.1">
        <property type="protein sequence ID" value="ENSCJPP00005008821.1"/>
        <property type="gene ID" value="ENSCJPG00005007831.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107314105"/>
    <dbReference type="CTD" id="10574"/>
    <dbReference type="GeneTree" id="ENSGT00550000074832"/>
    <dbReference type="OrthoDB" id="1935484at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044297">
        <property type="term" value="C:cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007339">
        <property type="term" value="P:binding of sperm to zona pellucida"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032212">
        <property type="term" value="P:positive regulation of telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd03340">
        <property type="entry name" value="TCP1_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000045">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000022">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000049">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000006">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012720">
        <property type="entry name" value="Chap_CCT_eta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02345">
        <property type="entry name" value="chap_CCT_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 14" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="523"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="535"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00093428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU365042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005008821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="544" mass="59446" checksum="E0C879CADF61E567" modified="2022-01-19" version="1">MMPTPVILLKEGTDTSQGIPQLVSNINACQVIAEAVRTTLGPRGMDKLIVDDRGKATISNDGATILKLLDVVHPAAKTLVDIAKSQDAEVGDGTTSVTLLAAEFLKQVKPYVEEGLHPQIIIRAFRTATQLAVNKIKDIAVSVKKEDKDEQRSLLEKCAATALSSKLISQSKEFFSKMVVDAVMMLDDLLQLKMIGIKKVQGGALEDSQLVAGVAFKKTFSYAGFEMQPKKYQSPKIALLNVELELKAEKDNAEVRVNTVEDYQAIVDAEWNILYDKLDKIHKSGAKVVLSKLPIGDVATQYFADRDMFCAGRVPEEDLKRTMMACGGSIQTSVNALSDDVLGRCELFEETQIGGDRYNFFTGCPKAKTCTIILRGGAEQFMEETERSLHDAIMIVRRAIKNDSVVAGGGAIEMELSKYLRDYSRTIPGKQQLLIGAYAKALEIIPRQLCDNAGFDATNILNKLRAKHAQGGMWYGVDVNNEDIADNFEACVWEPAIVRINALTAASEAACLIVSVDETIKNPRSTVDAPPGGRGRGRGRPHNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T887</accession>
    <name>A0A8C2T887_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Superkiller complex protein 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">WD repeat-containing protein 61</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">SKIC8</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the SKI8 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T887"/>
    <dbReference type="Ensembl" id="ENSCJPT00005013653.1">
        <property type="protein sequence ID" value="ENSCJPP00005009110.1"/>
        <property type="gene ID" value="ENSCJPG00005008060.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107318607"/>
    <dbReference type="KEGG" id="cjo:107318607"/>
    <dbReference type="CTD" id="80349"/>
    <dbReference type="GeneTree" id="ENSGT00940000153533"/>
    <dbReference type="OrthoDB" id="17410at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000791">
        <property type="term" value="C:euchromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055087">
        <property type="term" value="C:Ski complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045638">
        <property type="term" value="P:negative regulation of myeloid cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070478">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000094">
        <property type="entry name" value="WD repeat-containing protein 61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051510">
        <property type="entry name" value="SKI8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44090:SF1">
        <property type="entry name" value="SUPERKILLER COMPLEX PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44090">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="12"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="60"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="144"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="186"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="228"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="270"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005009110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="305" mass="33227" checksum="A75B015FA81275CB" modified="2022-01-19" version="1">MTTQYGILFKQEQAHDDAIWSVAWGKNKNDGSETVISGSLDDLVKVWKWNDEKLDLQWTLEGHQLGVVSVDISHTGSIAASSSLDAHIRLWDLETGKQIKSIDAGPVDAWSLAFSPDSQFLATGSHVGKVNIFGVETGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHGSWVLNVAFCPDDTHFVSSSSDKSVKVWDAGTRTCVHTFLDHQDQVWGVKYNGSGSKIVSVGDDQEIHIYDCPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T9J9</accession>
    <name>A0A8C2T9J9_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dimethylarginine dimethylaminohydrolase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">DDAH1</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DDAH family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T9J9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005014151.1">
        <property type="protein sequence ID" value="ENSCJPP00005009474.1"/>
        <property type="gene ID" value="ENSCJPG00005008314.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157892"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016403">
        <property type="term" value="F:dimethylargininase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000052">
        <property type="term" value="P:citrulline metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006527">
        <property type="term" value="P:L-arginine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900038">
        <property type="term" value="P:negative regulation of cellular response to hypoxia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043116">
        <property type="term" value="P:negative regulation of vascular permeability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045429">
        <property type="term" value="P:positive regulation of nitric oxide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003073">
        <property type="term" value="P:regulation of systemic arterial blood pressure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.75.10.10:FF:000004">
        <property type="entry name" value="N(G),N(G)-dimethylarginine dimethylaminohydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.75.10.10">
        <property type="entry name" value="L-arginine/glycine Amidinotransferase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033199">
        <property type="entry name" value="DDAH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12737">
        <property type="entry name" value="DIMETHYLARGININE DIMETHYLAMINOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12737:SF17">
        <property type="entry name" value="N(G),N(G)-DIMETHYLARGININE DIMETHYLAMINOHYDROLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02274">
        <property type="entry name" value="ADI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55909">
        <property type="entry name" value="Pentein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="304"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="405"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="209"/>
            <end position="210"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="399"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR633199-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR633199-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005009474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="416" mass="44136" checksum="ADD62C3BB11CC642" modified="2022-01-19" version="1">MPGTWHPKPQRCGTGAAPAAQPGTELRVGPNPRDPLAEPWLSPLDAARVPAPPPTAQVSGAPRGAANGAARPPPPANGSALGCGPMEICLVGSQWGAAGPRAALYQLPGPAVAAAARSRVARILPRPRTVMAGLGGGPAAFGRCTHAVVRALPESLCRQALRSTAGPEVDFARAEREHQLYVGVLRGKLGLQVLELPADESLPDCVFVEDAAVVCEETALLTRPGAPSRRKEVEAMKRVLESLNLNMVEMVDENATLDGGDVLFTGREFFVGLSKRTNQRGAEILADTFKDYAVSTVPVHDSLHLKSFCSMAGPNLIAIGSSEAAQKALKTMQQMSDHRYDKLTVPDDAAANCIYLNIPSKGHVLLHRAPEEYPESAKVFEKLKDHMLIPIANTELEKVDGALTCCSVLINKTSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TA39</accession>
    <name>A0A8C2TA39_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein broad-minded</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">TBC1 domain family member 32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">TBC1D32</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Required for high-level Shh responses in the developing neural tube. Together with CDK20, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to Shh signaling.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015714236.1">
        <property type="nucleotide sequence ID" value="XM_015858750.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015714237.1">
        <property type="nucleotide sequence ID" value="XM_015858751.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005015597.1">
        <property type="protein sequence ID" value="ENSCJPP00005010557.1"/>
        <property type="gene ID" value="ENSCJPG00005009170.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107311873"/>
    <dbReference type="KEGG" id="cjo:107311873"/>
    <dbReference type="CTD" id="221322"/>
    <dbReference type="GeneTree" id="ENSGT00940000153528"/>
    <dbReference type="OrthoDB" id="1668230at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007368">
        <property type="term" value="P:determination of left/right symmetry"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042733">
        <property type="term" value="P:embryonic digit morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007507">
        <property type="term" value="P:heart development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001822">
        <property type="term" value="P:kidney development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002088">
        <property type="term" value="P:lens development in camera-type eye"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061512">
        <property type="term" value="P:protein localization to cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003406">
        <property type="term" value="P:retinal pigment epithelium development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060021">
        <property type="term" value="P:roof of mouth development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060831">
        <property type="term" value="P:smoothened signaling pathway involved in dorsal/ventral neural tube patterning"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="TBC1 domain family, member 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BROMI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032735">
        <property type="entry name" value="BROMI_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055391">
        <property type="entry name" value="BROMI_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039156">
        <property type="entry name" value="PHAF1/BROMI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13465:SF3">
        <property type="entry name" value="PROTEIN BROAD-MINDED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13465">
        <property type="entry name" value="UPF0183 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14961">
        <property type="entry name" value="BROMI"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BROMI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23431">
        <property type="entry name" value="BROMI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BROMI N-terminal" evidence="11">
        <location>
            <begin position="12"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="BROMI middle region" evidence="10">
        <location>
            <begin position="173"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="domain" description="BROMI C-terminal Rab TBC-like" evidence="12">
        <location>
            <begin position="862"/>
            <end position="1293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00054310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00067690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00075916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14961"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF23431"/>
        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF23440"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005010557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1298" mass="148509" checksum="2C807C2D9D630885" modified="2022-01-19" version="1">MSQFTNEDEALLQSMLRQLLQSVKEKITGAPSVECAEEILLHLEETDENFHNYEFVKYLRQYINNTLGSVIEEESEKCTSIQNQTEVSGYDTLVQHVTKKTRESKQYREMMHALKNVMMVVVESLINKFEEDRMCNKELDSKTKKKCQSDYYTDNYSDSDSSFNQSYTFMSQEQLQLLVEKLDPIQPKEVRQEALQMLCLAPPSDVLNSECWPNLRKHLMMSLSDPDAIFSEKVLRFYAKTFSSSPFNMTREVYTSLAQHLELYFLSGEYSLRISSGLDVSNADVNHILKKVRLLNEYQKEAPSSWIRYPEKYMEEVVESTLSLLSVKHDPNHPASPDFLSPICFLALLDIKAVWFKKWTHAHYSRTVILRLLEKKYKSLINAAVQQCFDYFEFCKAAVGKTSRVNDFSQQHSCNEQKFFYTGSDLQYICFVHSLCLLGRLLIYKQGRNLFPVQLKNKKDCVSLTDLLVLFTQLIYYSPSYSKEALTAHTDSYSPASLVMEILQVFCDQTGCAADCLYTDEVMDALLDPLQSLLNGTEVYINCPETTLIDLADILARIAAAEDGLSVLLYGGNKNCAKENSPTAVHVIVQFTKKLLHDDISLLSGSELLQVVKGAFIFVCRQMYRTCEGLQMLIPYGLHESIGEAWKKASLLSERATGADSTSSISLDSKNILLWEETLLDALLNFSATPKGLFLLHSTGAMSDCVSFMFNSLSKKHQQTNEREEFGNGVIVAQMATTPAAAVALQSSGFIKAFVAELWALLECGKDDVRITQPKSTPVDAIDQSCQKSFLYLINLLTYPAVFELLSKQDIPNKPMYSHREVPTDIINIIDRIIILNSEAKIHSLFNYEQSHVFGLRLLNVLCCELDTLLLLETQYKVSEVLLTAQKENVTEASEGPGEFIIDSLSVERNHILVRINLIGGPRERILPLRALDKGNDPYPWPMFSSFPLPKCYLAEAPRKDDFGQDKDLDKLLSILQNPEEQTEWAEICRRQFCKIMKTRPDIISGAILAELIEKFVLRLSESRSNCYFSKGRYEATDADMKKESLSSVQQLGIEMTVRYGKYLNLLKEHAENELCFVLLNCEQFLKQQQRTVVSSLRCLQGRYAGYDWFASSVFLIMSGDGEKTLTFLQQFSHLLVSAFLWIPRLHMSMHLPITTVESGIHPVYFCSAHYIEMLLKAELPLVFAAFHMSAFTPSQICLQWITQCFWNYMDWSEICHYIATCIFLGPDYQVYMCISVFRHLQQDILKHTEAQDLQVFLKEEALHGFRVSDYLEYMESLELIYRPALMKDMRNIKVQNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TBW3</accession>
    <name>A0A8C2TBW3_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Scaffold attachment factor B1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC107325413</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TBW3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005016622.1">
        <property type="protein sequence ID" value="ENSCJPP00005011373.1"/>
        <property type="gene ID" value="ENSCJPG00005009767.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155916"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12679">
        <property type="entry name" value="RRM_SAFB1_SAFB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000897">
        <property type="entry name" value="Scaffold attachment factor B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.720.30:FF:000005">
        <property type="entry name" value="scaffold attachment factor B2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051738">
        <property type="entry name" value="SAF_Modulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034781">
        <property type="entry name" value="SAFB1_2_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15683">
        <property type="entry name" value="SCAFFOLD ATTACHMENT FACTOR B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15683:SF6">
        <property type="entry name" value="SCAFFOLD ATTACHMENT FACTOR B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="7 13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="SAP" evidence="16">
        <location>
            <begin position="166"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="15">
        <location>
            <begin position="564"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="202"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="298"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="392"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="635"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="846"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="931"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="298"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="392"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="416"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="504"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="534"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="635"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="723"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="745"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="931"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="992"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="1031"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1079"/>
            <end position="1093"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005011373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1093" mass="122633" checksum="8B9C1914BBB2912A" modified="2022-01-19" version="1">MAPNALLRVRGEAYTTHCACVSSEGVMSLLRMRGEAYTSQCACVARTTHRTAHACRARGWCLCCACAARPTHRAAHPCLACLCCVCCACAVLLSLRRGLRACALRSLVSLSATATILCCDRHRLHPVVLNRNNGPMADGHSAAGQGEYVSLSGCGTPGSEPETRRLSELRVIDLRAELKRRSLDSAGNKSVLSERLRRAIEEEGGNPDEIPVISENTIKRTPKRSSKGRRPDEEGAEDNGLEEDSGDGQEDIEASLDTLQDIDMMDISVLDEAEIDNGNAVDCGEDYSADHILDSLSDSKENTDADMKEHPGQPADYNVGNLEASPQYSDVKEESREIPVMMVEAEDVGNSFDAASSELIEIKEIEELPLEPENEKILDILGETCKSELLNEEACEAEQPDAQEASNVVPGKRLAEEEDALAAAQSEEDALDLDSKSAQAMARKEAKRLVVAKGETSEQTIEEEKLDSASVGVESVSDESSKRCQGLEASSGETAERGAGAEGKASKEDAKKAEDKANSEESPATKESSASEGGDQKKSPVEEDRDTKQASKDEKGRAGSGSGRNLWVSGLSSSTRATDLKNLFSKYGKVVGAKVVTNARSPGARCYGFVTMSTSEEATKCINHLHRTELHGKMISVEKAKNEPAGKKPSDRKEGEARKEKDRHHSADSKSEKSVGVKKEEKADKKDDAKKSEKDSKDEKEGKEKEEQKASDRSRASKSASRGTERTVVMDKSKGEPVISVKTSASKERSTKSQDRKSESKEKQDILSFDKIKEQRERERQRQREREIRETERRRERERREREQRLQAMHERDERQRLQRERERLEFQRQRLDRERLERERLERERMHIEQERRREQERIQREREELRRQQEQLRYEQERRSAMRRPYDDGRRDDPYWPEAKRMALDDRYHSEFVRQDRFHDFDHRDRGRYQDHSLDRREGSRGIPDRDGQHYPDERHGGPERHARESREGWGGYGSERRMTEGRGIPPQTRDGRDWGDHGRKLEGHQDRSWQGSVAGGMMGRDHERWQGGDRGAPGQLGPGHAMHRGGMAGRGGFTQGPNQSQVAPSAAVQGGFAGQERTHRATEPRFARRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TBX9</accession>
    <name>A0A8C2TBX9_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sesquipedalian</fullName>
            <shortName evidence="9">Ses</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">PH domain-containing endocytic trafficking adaptor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">PHETA2</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7 9">Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Early endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 9">Recycling endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 9">Golgi apparatus</location>
            <location evidence="2 9">trans-Golgi network</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Cytoplasmic vesicle</location>
            <location evidence="9">Clathrin-coated vesicle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the sesquipedalian family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015716829.1">
        <property type="nucleotide sequence ID" value="XM_015861343.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TBX9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005015447.1">
        <property type="protein sequence ID" value="ENSCJPP00005010434.1"/>
        <property type="gene ID" value="ENSCJPG00005009086.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107313246"/>
    <dbReference type="KEGG" id="cjo:107313246"/>
    <dbReference type="CTD" id="150368"/>
    <dbReference type="GeneTree" id="ENSGT00940000162686"/>
    <dbReference type="OrthoDB" id="10261837at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001881">
        <property type="term" value="P:receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13288">
        <property type="entry name" value="PH_Ses"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000250">
        <property type="entry name" value="Sesquipedalian-1 isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045188">
        <property type="entry name" value="Boi1/Boi2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22902">
        <property type="entry name" value="SESQUIPEDALIAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22902:SF15">
        <property type="entry name" value="SESQUIPEDALIAN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="4 9" id="KW-0967">Endosome</keyword>
    <keyword evidence="5 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="3 9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="11">
        <location>
            <begin position="17"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="147"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="147"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00055391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU369082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005010434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="251" mass="28458" checksum="132DE5675D2ABFE7" modified="2022-01-19" version="1">MKLNERSVAHYATCDSPTDHAGFLRKRVERHHHHGHHGTSYQRRWFVLKGNLLFYFEERDSREPVGLVVLEGCTVELCEAAEEFAFAIRFDDAGAKAYVLVADGQAAMEAWVKALSRASFDYMRLVVRELEKQLEEACSSLAACRKSPRKSSSGRRRHLSNPALPPVQEKQHVLENGYSTWGSSPDRDGGHAKPPPLPPRRRSAVGSSVPALQESPVSPETTCFAKLHHWYGQEIAVLRQEWQERQKRVHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TEC7</accession>
    <name>A0A8C2TEC7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Beta-alanine-activating enzyme</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Acyl-CoA synthetase family member 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">AASDH</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015717712.1">
        <property type="nucleotide sequence ID" value="XM_015862226.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TEC7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005018118.1">
        <property type="protein sequence ID" value="ENSCJPP00005012509.1"/>
        <property type="gene ID" value="ENSCJPG00005010637.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107313716"/>
    <dbReference type="CTD" id="132949"/>
    <dbReference type="GeneTree" id="ENSGT00440000033811"/>
    <dbReference type="OrthoDB" id="408177at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019482">
        <property type="term" value="P:beta-alanine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17654">
        <property type="entry name" value="A_NRPS_acs4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000027">
        <property type="entry name" value="AASDH isoform 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048005">
        <property type="entry name" value="AASDH_AMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052091">
        <property type="entry name" value="Beta-ala_Activ/Resist"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_b-propeller_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_rpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44394">
        <property type="entry name" value="BETA-ALANINE-ACTIVATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44394:SF1">
        <property type="entry name" value="BETA-ALANINE-ACTIVATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13570">
        <property type="entry name" value="Beta-prop_ACSF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="11">
        <location>
            <begin position="562"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00078906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005012509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1076" mass="119626" checksum="91B7B92E0A4842E1" modified="2022-01-19" version="1">MTLHDMVAQAASLHSGRKAVWFDGCNDEPPTFYTYATVIKHATELTAFLQKYCDPQGRCEIGLYCCPGINLPSWILGILQVPAAYCPIDPDAPPLLSTHFMRKSNLQYILVENDKIKQFQTSHAGWLSCSSSTIEHIGLTLFQVSRSSTDVNLKADNVKSKLEAFKVMGNSQLGNAVCSEHLELKASEEGYKDVGQRCSLAYVLHTSGTTGTPKIVRVPHTCIVLNIQHLKSIFEITQDDVLFLASPLTFDPSVVELFIALTSGASILIVPNAVKMMPVELSTALFNHHHVTVLQATPTLFRRFGAHIIKSTVLSADTSLRVLALGGEAFPVLNLWKSWKHKDNKTSIFNLYGITEVSSWATCYRIPEEVFSADFRTDFPVPLGSPLLGTLVEIRDANGSAVLEGEGQIFIGGAERICFLDDEIMVPQDTMRETGDFVRVQNAEIFFLGRKDNQIKRHGKRFNIECLQQAAEDLCQVEACAVTWYQQEKLILFVVPRGDLQERETLCELQKRLPTHGIPDELVQIRTLPLTSHGKVDISELNKIYHYHLNSRRRDSKLSGAEELWERLQYLWKSVLGLLDDSSGISKDAVFLYSGGDSFKALQFYDEIEMLVGRGVPGLLEVILSRPIEEVYKHILKTLFPDEDQLTNDDNVLKRKLSKNNGEEIHGKYAKLKSEGYLRAAPGLISFVALSRGNHFLTMHFTKSVMEQYSTEKVGGDAESSHLTTAELALRTRWKSDTRKCVDASPLIVISSKEEETASVFVGSHSHTMQSIDLETGEVKWEKNLGDRIESSACVSKCGHFIVVGCYDGLVYVLQSSDGETYWTFATEDTVKSSAVVDPSSGLVYVGSHDQHMYALDIYEKLCVWKLHCEGGAVFSSPCLSSFPHHVYVATLGGLLLAVDPVTGDKIWKSFLGKPLFSSPHCNEKCVCIGCVDGNLYCYNHSGEKVWQFSTNGPVFSSPCISSLTKQEVFFGSHDHFIYCCNMEGNLLWKFKATSSVYGTPFVFQSDDSKNKVLLAAVSTDGKVWILNARTGTAEGIDTLPGEVFSSPVVWGTKLVVGCRNDYVYCLDLYITGKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TF17</accession>
    <name>A0A8C2TF17_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Golgi associated, gamma adaptin ear containing, ARF binding protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">GGA2</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Early endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GGA protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TF17"/>
    <dbReference type="Ensembl" id="ENSCJPT00005017458.1">
        <property type="protein sequence ID" value="ENSCJPP00005012002.1"/>
        <property type="gene ID" value="ENSCJPG00005010241.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159613"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034394">
        <property type="term" value="P:protein localization to cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd14239">
        <property type="entry name" value="GAT_GGA1_GGA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000023">
        <property type="entry name" value="ADP-ribosylation factor-binding protein GGA3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008153">
        <property type="entry name" value="GAE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038425">
        <property type="entry name" value="GAT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027422">
        <property type="entry name" value="GGA1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041198">
        <property type="entry name" value="GGA_N-GAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45905:SF2">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-BINDING PROTEIN GGA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45905">
        <property type="entry name" value="GOLGI-LOCALIZED, GAMMA-ADAPTIN EAR CONTAINING, ARF BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18308">
        <property type="entry name" value="GGA_N-GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50180">
        <property type="entry name" value="GAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50909">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="VHS" evidence="12">
        <location>
            <begin position="5"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="GAT" evidence="14">
        <location>
            <begin position="160"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="GAE" evidence="13">
        <location>
            <begin position="371"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="286"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="176"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005012002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="499" mass="55881" checksum="989457073DBD58EC" modified="2022-01-19" version="1">MLPEMTPASLQIEKWECIQQFCSQLNADTEGPPLAARLLAHKIQSPQEVEALHALTVLETCVNNCGEKFHNEIAKFRFLNELIKVLSPKYYGTWSSEKVKSRVTEIIFSWTVWFPQEVKIRDAYQMLKKQGIVKEDPKLPEDKILPPPSPRPQNSIFDTDEEKSKLLARLLKSNHAEDLQAANRLIKSMIKEEQEKSAKVSRRENTISEVSENVKRMDELLEGYKRQELPKSDHETLQSLFQRCEKLRPLLFRLASETVDDDEALAELLKANDRLTQVLGRYRQTVGSHEDGGGECSASSTSDTPGKEPHSVKYKSQATVVLCLAYEFAKASNSLYEFFLSADLSLPSLFCPQKRGEIHALSLIFLLSLAGSICPLTVYDKDGFKAMLHFSRDPAPGRPDVLVMVLSMLSTSAQPIQDIVFQAAVPKTMKIKLQPASGSELPAFSPLLPPAVVSQVLLLANPHKDPIRLKYKLAFRHGVQPVSEEGEVTGFPGAELWGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TGH3</accession>
    <name>A0A8C2TGH3_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Small glutamine-rich tetratricopeptide repeat-containing protein beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Beta-SGT</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">SGTB</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homooligomerize.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SGT family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TGH3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005018256.1">
        <property type="protein sequence ID" value="ENSCJPP00005012627.1"/>
        <property type="gene ID" value="ENSCJPG00005010731.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158321"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome Z"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072380">
        <property type="term" value="C:TRC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.420:FF:000002">
        <property type="entry name" value="Small glutamine-rich tetratricopeptide repeat-containing protein alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000103">
        <property type="entry name" value="small glutamine-rich tetratricopeptide repeat-containing protein beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.420">
        <property type="entry name" value="Immunoglobulin FC, subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047150">
        <property type="entry name" value="SGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032374">
        <property type="entry name" value="SGTA_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45831">
        <property type="entry name" value="LD24721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45831:SF1">
        <property type="entry name" value="SMALL GLUTAMINE-RICH TETRATRICOPEPTIDE REPEAT-CONTAINING PROTEIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16546">
        <property type="entry name" value="SGTA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="SGTA homodimerisation" evidence="13">
        <location>
            <begin position="89"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="11">
        <location>
            <begin position="170"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="11">
        <location>
            <begin position="204"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="11">
        <location>
            <begin position="238"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00058932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00063423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00070478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00079605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005012627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="334" mass="37367" checksum="9D36891EFE2744BD" modified="2022-01-19" version="1">MGREGEEGAREAGPRGEAEKGEGPAEKEEGPASLRCHRRPAAGRGHSRRDRAAAAAWRIRFRRLVRPVSGSSRRPARQEKFISLKMSSVKRLVYAFIHFLREQSQMETFTPDEQESLEVAIQCLETVFKVNLEDTHLAPPQHLIEIFANSFHKNDKLPLSDSLPEDIEKADHLKDEGNNHMKEENYGAAVDCYTRAIELDPNNAVYYCNRAAAQSKLSKYSEAIKDCERAIAIDPKYSKAYGRMGLALTSVNKYEEAITSYQKALDLDPENDSYKSNLKVAEQKLRDMSSPTGTGLSFDMASLINNPAFISMVSALQALHCIAFNAEILRTSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TGN6</accession>
    <name>A0A8C2TGN6_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Chromodomain-helicase-DNA-binding protein 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">ATP-dependent helicase CHD7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">CHD7</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSCJPT00005019267.1">
        <property type="protein sequence ID" value="ENSCJPP00005013405.1"/>
        <property type="gene ID" value="ENSCJPG00005010431.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153649"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990841">
        <property type="term" value="F:promoter-specific chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007512">
        <property type="term" value="P:adult heart development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007628">
        <property type="term" value="P:adult walking behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035909">
        <property type="term" value="P:aorta morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036302">
        <property type="term" value="P:atrioventricular canal development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008015">
        <property type="term" value="P:blood circulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001974">
        <property type="term" value="P:blood vessel remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060411">
        <property type="term" value="P:cardiac septum morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050890">
        <property type="term" value="P:cognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035116">
        <property type="term" value="P:embryonic hindlimb morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060429">
        <property type="term" value="P:epithelium development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060324">
        <property type="term" value="P:face development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030540">
        <property type="term" value="P:female genitalia development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060384">
        <property type="term" value="P:innervation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043584">
        <property type="term" value="P:nose development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042048">
        <property type="term" value="P:olfactory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021772">
        <property type="term" value="P:olfactory bulb development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021553">
        <property type="term" value="P:olfactory nerve development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040018">
        <property type="term" value="P:positive regulation of multicellular organism growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060123">
        <property type="term" value="P:regulation of growth hormone secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050767">
        <property type="term" value="P:regulation of neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010880">
        <property type="term" value="P:regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009617">
        <property type="term" value="P:response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060041">
        <property type="term" value="P:retina development in camera-type eye"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003226">
        <property type="term" value="P:right ventricular compact myocardium morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062009">
        <property type="term" value="P:secondary palate development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048752">
        <property type="term" value="P:semicircular canal morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007605">
        <property type="term" value="P:sensory perception of sound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001501">
        <property type="term" value="P:skeletal system development"/>
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        </source>
    </evidence>
    <sequence length="2996" mass="336289" checksum="BF113EF8B1D526D3" modified="2022-01-19" version="1">MADPGMMSLFGEDGNIFSEGLEGLGECGYPENTVNPMGQQMPMDQGFPSLQSSLHHPPANQNQAKLTHFDHYNQYEQQKMHLMDQPNRMISSAPGNGIASPHSQYHNPPVPQVPHGSGASGQMGVYPSMQNERHGQPFVDSGSMWGPRAVQVPDQIRAPYQQQQQQPQPTQPPQAPSGPPGQGHPQHMQQMGNYMARGDFSMQQHGQPQQQRMNQFSQGQEGLNQGNPFIATSGPGHLSHVPQQNPSMAPSLRHSVQQFHHHPPTALHGESVAHSPRFSPNPPQQGAVRPQTLNFSSRSQTVPSPTINNSGQYSRYPYSNLNQGLVNNTGMNQNLGLTNNTPMNQSVPRYPNAVGFPSNSGQGLMHQQPIHPSGSLNQMNTQTMHPSQPQGTYASPPPMSPMKAMSNPAGTPPPQVRPGSAGIPMEVGSYPNIPHPQPSHQPPGAMGIGQRNMGPRNMQQNRPFMGMSSTTREMGGHMRPNGCPGVGLADPQAIQERLISGQQLPSQQQSFQQQMPTCPPMQPHPGIHHQSSPPPHPHHQPWAQLHQSPQNTPQKVPVLQHSPSEPFLEKPVPDMTQVSGPNTQLVKSDDYLPSVEPQPQQKKKKKKNNHIAAEGPSKSFGKEDFPGGLDSQNLSRNSVDCSQEDKKKKKKPKAKKEPKDPKEPKEKKEPKTPKVPKTPKEPKEKKAKNTTPKPKTSKKTSNKKTDSETSAAKKKVNKGKEGSENSDLDKTPPPSPHPEDEDDAGVQKRRSSRQVKRKRYTEDLEFKISDEEADDADAAGRDSPSNTSQSEQQVRFEWNGKVDHAIKCSCELRFSVLSSSSYLHCQWASVEELDKDKRIQQKIKRFKAKQGQNKFLSEIDDELFNPDYVEIDRILDFSRSTDDNGEPVTHYLVKWCSLPYEDSTWELKQDIDQAKIEEFEKLMSREPEMERVERPPADDWKKSESSREYKNNNKLREYQLEGVNWLLFNWYNTRNCILADEMGLGKTIQSITFLYEIYLKGIHGPFLVIAPLSTIPNWEREFRTWTELNVVVYHGSQASRRTIQLYEMYFKDPQGRVIKGSYKFHAIITTFEMILTDCPELRNIPWRCVVIDEAHRLKNRNCKLLEGLKMMDLEHKVLLTGTPLQNTVEELFSLLHFLEPVRFPSETTFMQEFGDLKTEEQVQKLQAILKPMMLRRLKEDVEKNLAPKEETIIEVELTNIQKKYYRAILEKNFAFLSKGGGQANVPNLLNTMMELRKCCNHPYLINGAEEKILEEFKETHNADSPDFQLQAMIQAAGKLVLIDKLLPKLKAGGHKVLVFSQMVRCLDILEDYLIQRRYPYERIDGRVRGNLRQAAIDRFSRPDSDRFVFLLCTRAGGLGINLTAADTCIIFDSDWNPQNDLQAQARCHRIGQSKSVKIYRLITRNSYEREMFDKASLKLGLDKAVLQSMSGRENATNGVQQLSKKEIEDLLRKGAYGALMDEEDEGSKFCEEDIDQILLRRTHTITIESEGKGSTFAKASFVASGNRTDISLDDPNFWQKWAKKAELDIDALNGRNNLVIDTPRVRKQTRLYSAVKEDELMEFSDLESDSEEKPSTKPRRPQDKSQGYARSECFRVEKNLLVYGWGRWTDILSHGRYKRQLTEQDVETICRTILVYCLNHYKGDENIKSFIWDLITPTADGQTRALVNHSGLSAPVPRGRKGKKVKAQSSQPMLQDADWLTTCNPDVLFQEDSYRKHLKHHCNKVLLRVRMLYYLRQEVIGDQADRILEGADSSEVDVWIPEPFHAEVPADWWDKEADKSLLIGVFKHGYEKYNSMRADSTLCFLERVGMPDAKAIAAEQRGTDMLADGGDGGEFDREDEDPEYKPTRIPFKDEIDEFANSPPEDKEESIEIHPNKHSESNSELGQLYWPNTSTLTTRLRRLITAYQRSYKRQQMRQEALMKTDRRRRRPREEVRALEAEREAIITEKRQNINWEEADFYRVVSTFGIIFDPIKHQFDWNQFRAFARLDKKSDESLEKYFNGFVNMCRRVCRMPVKPDDEPPDLSTMIEPITEERASRTLYRIELLRKIREQVLHHPQLGERLKLCQPSLDLPEWWECGKHDKDLLIGAAKHGVSRTDYHILNDPELSFLEAHKNFAQNRGAGNANTVSSLHPVGAGCSQTPPIVPSTPVQEEKSTEQTESKVEGSENPAAKEKSDVKEETDIADKDTKQDCDAEAETGSVKCELKDIEMSTDVDPKSISEKGSEEDEEEKLDDDDKSEESSQPEAGAVSQGKNFDEESNASMSTARDETRDGFYMEDGDPSVVQLLHERTFAFSFWPKDRVMINRLDNICEAVLKGKWPVNRRQMFDFQGLIPGYTPTAVDSPLQKRSFAELSMIGQASISGSEDITASPQLSKEDALNLSVPRQRRRRRRKIEIEAERAAKRRNLMEMVAQLRESQVVSENGQEKVVDLSKASREATSSTSNFSSVTSKFILPNVSTPVSDAFKTQMELLQAGLSRTPTRHLLNGSLIDGEPPMKRRRGRRKNVEGLDLLFMSNKRTSLTVEDAEVTKAFEEDMEALPARNIPSPGQLDPDTRIPVINLEDGTRLVGEDAPKNKDLVEWLKLHPTYTVDMPSYVPKSADVLFSSFQKPKQKRHRCRNPNKLDINTLTGEERVPVVNKRNGKKMGGAMAPPMKDLPRWLEENPEFAVAPDWTDIVKQSGFVPESMFDRLLTGPVVREEGASRRGRRPKSEIAKAAAAAAAVASTSGINPLLMNSLFAGMDLTSLQNLQNLQSLQLAGLMGFPPGLATAAAAGGDAKNPAAMLPLMLPGMAGLPNMFGLSGLLNNPITATTGNATTASGQGETEDGASKGEEKKKENEEENKDSEKSTDTVSATDSANGSVSAATAATTATATTTTTTNTGLPTNPLAFNPFLLSTMAPGLFYPSMFLPPGLGGLTLPGFPALAGLQNAVGSNEEKATEKTEGTAFKDEENLEGSDAEESLDKTADSSVLEDEIAQGEELDSLDGGEEIENNENDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2THR7</accession>
    <name>A0A8C2THR7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphatidate phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LPIN1</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:27429"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="3.1.3.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:27430"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the lipin family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.4" evidence="4"/>
    <dbReference type="RefSeq" id="XP_015714923.1">
        <property type="nucleotide sequence ID" value="XM_015859437.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2THR7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005018830.1">
        <property type="protein sequence ID" value="ENSCJPP00005013073.1"/>
        <property type="gene ID" value="ENSCJPG00005011058.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107312217"/>
    <dbReference type="KEGG" id="cjo:107312217"/>
    <dbReference type="CTD" id="23175"/>
    <dbReference type="GeneTree" id="ENSGT00940000157219"/>
    <dbReference type="OrthoDB" id="4567at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032869">
        <property type="term" value="P:cellular response to insulin stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046337">
        <property type="term" value="P:phosphatidylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026058">
        <property type="entry name" value="LIPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031703">
        <property type="entry name" value="Lipin_mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007651">
        <property type="entry name" value="Lipin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013209">
        <property type="entry name" value="LNS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031315">
        <property type="entry name" value="LNS2/PITP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12181">
        <property type="entry name" value="LIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12181:SF10">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE LPIN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16876">
        <property type="entry name" value="Lipin_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04571">
        <property type="entry name" value="Lipin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08235">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00775">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LNS2/PITP" evidence="7">
        <location>
            <begin position="787"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="182"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="275"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="424"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="507"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="208"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="220"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="275"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="322"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="512"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005013073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1003" mass="111011" checksum="2605E7ECB970613A" modified="2022-01-19" version="1">MGENDHFKMSSEDEEQPESPPGSPWSWILLMKDPAWIRNVWTRNLNVQTMNYVGQLAGQVFVTVKELYKGLNPATLSGCIDIIVVRQPDGNLQCSPFHVRFGKMGVLRSREKVVDIEINGEAVDLHMKLGDNGEAFFVQEMDNDQEVIPYHLSTSPILSEGTALMEAQLKRNSIDRIRNLDNSVSSQVPPQAHGSQPGTETSAVCSSVKKRRKKRRKSTHKIDSLKREDVGDTSEDEDMFPIEISSEEEKEPLDSPRILVPDVFVDEVSDIKAPTVSTYSQSSSYPRSDGEWSPIQSKPIDCTGQSSLLTVPADGGLSNSCPHQSSHFSPPDSSSGSRPPTPQSDSELVSKPTDRSGLKNPHMHWAWGELPQAKKASSLIKAKEPNTIDVNPSESTHFRVIQSDPIEEFNGASPLPALGHADAAAADETEPLPAETNKPETESAGAAVPSLPANEEIKQAASCSAQAVGKTDSPSRKKDKRSRHLGADGVYLDDLTDMDPEVAALYFPKNGDNIQNRNTNDTGPRSATHSPQSFGSSGADSGVESTSDGTRDLPSIAISLCGGLTDNKEITKEEFLEHAVTYQQFVDNPAIIDDPNLVVKIGNKYYNWTTAGPLLLAMQAFQKPLPKATVESIMRDKMPKKGGRWWFSWRGRNSTIKEETKAEQGMSGSRLKGEDSSEMSIANRKFRRVTVSRLLVACDRIKDESSSSDEDPRAAKQNLGSLQANSSHLSLLSGISYKKTLRLTSDQLKSLKLKNGPNDVTFSVTTQYQGTCRCEGTIYLWDWDDKVIISDIDGTITRSDTLGHILPTLGKDWTHQGIAKLYHKVSQNGYKFLYCSARAIGMADMTRGYLHWVNERGTVLPQGPVLLSPSSLFSALHREVIEKKPEKFKVQCLTDIKNLFYPNTEPFYAAFGNRPADVYSYKQVGVSLNRIFTVNPKGELIQEHAKTNISSYVRLCEVVDHIFPLLKRSHSSDFPCSDTYSQFTYWREPLPPFETQDVHPDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TI62</accession>
    <name>A0A8C2TI62_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Catechol-O-methyltransferase domain containing 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">COMTD1</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TI62"/>
    <dbReference type="Ensembl" id="ENSCJPT00005018551.1">
        <property type="protein sequence ID" value="ENSCJPP00005012848.1"/>
        <property type="gene ID" value="ENSCJPG00005010902.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000004409"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050362">
        <property type="entry name" value="Cation-dep_OMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10509:SF93">
        <property type="entry name" value="CATECHOL O-METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10509">
        <property type="entry name" value="O-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005012848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="342" mass="37805" checksum="D3D1E2EEEA1E83CA" modified="2022-01-19" version="1">MLAESRAQPFLHRYSIRPRGKTQHPSTSLSLAARGTNVMQEPPSGREEAVPGRPAPRGEQLRPTRLRRDRAAPLAAASPRPEMPLFSVPKEVAVGTAMLGVAFATGMLAGKRYPSLLFGTSKPHKSIIGKSSPLWQYILDHSLREHPILKKLRLLTAEYPWGKMMVSCDQAQLMANLIKLIKAKKVIEVGVLTGYNALSMALALPDNGRVIACDINEDYAKIGKPLWKEAGVDHKIDLRIKPATQTLDELLAGGEAETFDFAFIDADKESYNEYYEKCLRLIKKGGIIAIDNVLRGGMVLKPRKDDLATQSIHHLNEKLVRDARVNISMIPMGDGVTLVFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TIX3</accession>
    <name>A0A8C2TIX3_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane protein 259</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">TMEM259</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015741782.1">
        <property type="nucleotide sequence ID" value="XM_015886296.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TIX3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005017897.1">
        <property type="protein sequence ID" value="ENSCJPP00005012339.1"/>
        <property type="gene ID" value="ENSCJPG00005010494.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107325435"/>
    <dbReference type="KEGG" id="cjo:107325435"/>
    <dbReference type="CTD" id="91304"/>
    <dbReference type="GeneTree" id="ENSGT00390000013329"/>
    <dbReference type="OrthoDB" id="6779347at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904294">
        <property type="term" value="P:positive regulation of ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019144">
        <property type="entry name" value="Membralin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21650:SF4">
        <property type="entry name" value="MEMBRALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21650">
        <property type="entry name" value="MEMBRALIN/KINETOCHORE PROTEIN NUF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09746">
        <property type="entry name" value="Membralin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="362"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="392"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="421"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="633"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="493"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="517"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="662"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005012339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="735" mass="81190" checksum="BCC4332C28732878" modified="2022-01-19" version="1">MSEAQPHGQHPQPNHTGAAGGTNRAGRNAALNQNPLINVRDRLFHALFFKMAVTYARLFPPSFRRVFEFFVLLKALFVLFILAYIHIAFSRSPINCLEHVRDKWPRDGILRVEIQRNSSRAPIFLQFCGAEKFPGMVVEPTAEEEEEEEEEMTVDMFENSSIKFELDIEPKVFLKPSRMSSTEALAHNESQEFSFSEAATKGMQPLRETVSEFEMLARAVWPQEEYIVEYSLEYGFLRLSQSTRQRLSIPVMVVTLDPTRDQCFGDRFSRLLLDEFLGYDDILMSSVKALAENEENKGFLRNVVSGEHYRFVSMWMARTSYLAAFVIMVIFTLSVSMLLRYSHHQIFVFIVDLLQMLEMNMTIAFPAAPLLTVILALVGMEAIMSEFFNDTTTAFYIILIVWLADQYDAICCHTNTSKRHWLRFFYLYHFAFYAYHYRFNGQYSSLALVTSWLFIQHSMIYFFHHYELPAILRQIRIQEMLLQNQQVGQGTQTTLQDNLNNNTTPAGAEVGSHRPHLAAGPSEESSSPAALAPGEASSVISTAAASSVGSDLNWVAETAAIVTEASFLSDLSSSLLEPNVVHEAVAAGSPQDAAAASSLVARIRVSSDHPDTAVGSITIEVTSASVVAAADGPTAAASPPISVQEDGASIPSPSPADEQTEAVESSDSQAKPSGKNCIANGSVAESPPAFVDNTDQDKLLGCTLGDRGESGPCPAPADSTASSRPCSEPDLRSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TIY1</accession>
    <name>A0A8C2TIY1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nuclear receptor-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">NRBP1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="9">Homodimer. Binds to MLF1, recruiting a serine kinase which phosphorylates both itself and MLF1. Phosphorylated MLF1 binds to YWHAZ and is retained in the cytoplasm. Interacts with ELOC/TCEB1, ELOB/TCEB2, TSC22D2 and TSC22D4. Interacts with the Elongin BC E3 ubiquitin ligase complex via its interaction with ELOB/TCEB2 and ELOC/TCEB1. Interacts with SALL4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Lamellipodium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015714992.1">
        <property type="nucleotide sequence ID" value="XM_015859506.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TIY1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005020332.1">
        <property type="protein sequence ID" value="ENSCJPP00005014246.1"/>
        <property type="gene ID" value="ENSCJPG00005011910.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107312258"/>
    <dbReference type="CTD" id="29959"/>
    <dbReference type="GeneTree" id="ENSGT00940000155605"/>
    <dbReference type="OrthoDB" id="1034557at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd14034">
        <property type="entry name" value="PK_NRBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000181">
        <property type="entry name" value="Nuclear receptor-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000098">
        <property type="entry name" value="Nuclear receptor-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050588">
        <property type="entry name" value="WNK_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13902">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE WNK WITH NO LYSINE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="68"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00063706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005014246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="532" mass="59726" checksum="BAE1291715F97DDE" modified="2022-01-19" version="1">MSEGEAKQAPSGGSDPKPESASSGPGMTSVSAPVTSSAPPEEEEEEEESEDESEILEESPCGRWQKRREEVNQRNVPGIDSAYLAMDTEEGVEVVWNEVQFSERKNFKLQEEKVKAVFDNLIQLEHLNIVKFHKYWADVKENKARVIFITEYMSSGSLKQFLKKTKKNHKTMNEKAWKRWCTQILSALSYLHSCDPPIIHGNLTCDTIFIQHNGLIKIGSVAPDTINNHVKTCREEQKNLHFFAPEYGEVANVTTAVDIYSFGMCALEMAVLEIQGNGESSYVPQEAINSAIQLLEDPLQREFIQKCLEQDPGKRPTARELLFHQALFEVPSLKLLAAHCIVGHQHMIPENALEEMTKNLDMSAVLAEINHADREGVKMIFSQSPALELDKFLEDVRNGIYPLTAFGMPRPQQPQQVVVKSPIAPPSVKTPTPEPAEVETRKVVLMQCNIESVEEGVKHHLTLLLKLEDKLNRHLSCDLQPNDNIQELAAELVQLGFISEADQSRLTCLLEEAFSKFYYTRNGALTAVTVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TJP0</accession>
    <name>A0A8C2TJP0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleotide exchange factor SIL1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">SIL1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Required for protein translocation and folding in the endoplasmic reticulum (ER). Functions as a nucleotide exchange factor for the ER lumenal chaperone HSPA5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SIL1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015731507.1">
        <property type="nucleotide sequence ID" value="XM_015876021.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015731508.1">
        <property type="nucleotide sequence ID" value="XM_015876022.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015731509.1">
        <property type="nucleotide sequence ID" value="XM_015876023.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015731510.1">
        <property type="nucleotide sequence ID" value="XM_015876024.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TJP0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005019384.1">
        <property type="protein sequence ID" value="ENSCJPP00005013500.1"/>
        <property type="gene ID" value="ENSCJPG00005011384.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107320309"/>
    <dbReference type="KEGG" id="cjo:107320309"/>
    <dbReference type="CTD" id="64374"/>
    <dbReference type="GeneTree" id="ENSGT00940000153909"/>
    <dbReference type="OrthoDB" id="448649at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000148">
        <property type="entry name" value="SIL1 nucleotide exchange factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050693">
        <property type="entry name" value="Hsp70_NEF-Inhibitors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013918">
        <property type="entry name" value="Nucleotide_exch_fac_Fes1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19316:SF35">
        <property type="entry name" value="NUCLEOTIDE EXCHANGE FACTOR SIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19316">
        <property type="entry name" value="PROTEIN FOLDING REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08609">
        <property type="entry name" value="Fes1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034734546" description="Nucleotide exchange factor SIL1" evidence="13">
        <location>
            <begin position="38"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleotide exchange factor Fes1" evidence="14">
        <location>
            <begin position="153"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="101"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="144"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005013500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="466" mass="52300" checksum="ED0C9579A3345068" modified="2022-01-19" version="1">MRGWVAMSHWAGLLCTAAKVSLLLLLVSAVFFQSSLSDRVPEFALTKIEESDIKDDSGKEPITDDDADPEDLEVFYPTHQWQAVRPGQAVPAGSHVRLNLQTGEREARLPDSESGKSDAKEEKRRRRLNKMDIDTNSFTSQELKKALAKMKENEKAERTAHEEEVRKKFRPIEQLKEEFEKLNVKMETDYEIMDKLISKFNSSASTLDEKVAALYDLEYYVHQVDNAKDFLSMGGLRLVIEGLNSTEAVLKEHAAFVLGAALSSNPKVQVEAIEGGALQKLLVIVATEQPQAVKKKALFALSSLLRHFPYAQQQFLKLGGLQVLRGLFRQPGTSALCVRAVTLLYDLIVEKMLLEDSQHSDHMEKVQQYRRVQLVPAVLEQDWCVAVPGLLALPEHDAREKVLKAVSVLMELCRERFRGDTALSATLGMLRSEYEELAAAERRDGDGDGYFQELLGAVNSIVRELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TK69</accession>
    <name>A0A8C2TK69_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Annexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ANXA4</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="domain">
        <text evidence="6">A pair of annexin repeats may form one binding site for calcium and phospholipid.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the annexin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TK69"/>
    <dbReference type="Ensembl" id="ENSCJPT00005019996.1">
        <property type="protein sequence ID" value="ENSCJPP00005013977.1"/>
        <property type="gene ID" value="ENSCJPG00005011724.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156575"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048306">
        <property type="term" value="F:calcium-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051059">
        <property type="term" value="F:NF-kappaB binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140416">
        <property type="term" value="F:transcription regulator inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030855">
        <property type="term" value="P:epithelial cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043124">
        <property type="term" value="P:negative regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032717">
        <property type="term" value="P:negative regulation of interleukin-8 production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010804">
        <property type="term" value="P:negative regulation of tumor necrosis factor-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000002">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000022">
        <property type="entry name" value="Annexin A5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.10">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001464">
        <property type="entry name" value="Annexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018502">
        <property type="entry name" value="Annexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018252">
        <property type="entry name" value="Annexin_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037104">
        <property type="entry name" value="Annexin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502">
        <property type="entry name" value="ANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502:SF28">
        <property type="entry name" value="ANNEXIN A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00191">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00196">
        <property type="entry name" value="ANNEXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00335">
        <property type="entry name" value="ANX"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47874">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00223">
        <property type="entry name" value="ANNEXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51897">
        <property type="entry name" value="ANNEXIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0041">Annexin</keyword>
    <keyword evidence="3 6" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 6" id="KW-0111">Calcium/phospholipid-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005013977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="296" mass="33012" checksum="92512076667F22C3" modified="2022-01-19" version="1">HSGSLTGFHLFLAGTDEEIIIDILTKLNASQRQVGGLQRCDLIGDLTLLSGNFERVMVGMMTPTAMSDVHKVRRAVKVSGTEEGCLMEILASCNSEEIHRINEISKLQYGCSVEDDVVSSTSSMFPRVLVSLATGNRDEGMYVDDALAQQDAVCLYEAGERKWGIDEVQFMSVLCTWNRHHLLRVLDVYRGISIKDITDSIKSGRSGDLEDALLVTVKCMRNKPAYFAERLYKSMKGLGTDDNTLIRVMVSRSEIDMLDIRREFLTMYGKSLHSFIKGDCSGDYRKVLLKLCGGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TLJ7</accession>
    <name>A0A8C2TLJ7_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Keratinocyte associated protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">KRTCAP3</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM54 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TLJ7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005020330.1">
        <property type="protein sequence ID" value="ENSCJPP00005014244.1"/>
        <property type="gene ID" value="ENSCJPG00005011908.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000004700"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020977">
        <property type="entry name" value="Beta-casein-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31258">
        <property type="entry name" value="KERATINOCYTE-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31258:SF1">
        <property type="entry name" value="KERATINOCYTE-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12304">
        <property type="entry name" value="BCLP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005014244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="236" mass="24962" checksum="1EF5964A3D089301" modified="2022-01-19" version="1">EGLSPACGFGAERGRLMRAGLALIVLGHSNLVLGAIVHGSVLRHVARAKGAVTPEYAVVNIVSVVSGLLSIAVGIVAILVSRNLARAALHWALLSVSLLNCLLSTACSVGLALAIALTIHSRGMRLVTGCNSPALPADARAAIATNDCPFNTTRIYDTALALWFPSMLLAATEAVLSGRCSLAALVLQGIGPWARSYSKRMGQPQPLPQQKIRTSEKSRKWLRKMKAMFSQLTAWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TLL7</accession>
    <name>A0A8C2TLL7_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mitochondrial ribosomal protein S24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MRPS24</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TLL7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005020205.1">
        <property type="protein sequence ID" value="ENSCJPP00005014137.1"/>
        <property type="gene ID" value="ENSCJPG00005011836.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000011179"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026146">
        <property type="entry name" value="Ribosomal_uS3m"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21244">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21244:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US3M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14955">
        <property type="entry name" value="MRP-S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005014137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="174" mass="19697" checksum="1FE8B029022BEB95" modified="2022-01-19" version="1">MAPCPHRALCPHTRCCPHLPPCPHRAPCPHSPPCPYRALCPHTWCSARVRVGKGDKPVTYEQAHPPHYIAHRKGWLSLHTGNLSGEPGAAQRTVEDAFLRRFFHGTFPGCLWEQLVVKRRCNVLLLCPVLLRQLPPAKLCFLLGYAETLLSHLYKCPVSIQVQTVPDRVIYKYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TLQ9</accession>
    <name>A0A8C2TLQ9_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Potassium channel subfamily K member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">KCNK3</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015715332.1">
        <property type="nucleotide sequence ID" value="XM_015859846.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TLQ9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005022230.1">
        <property type="protein sequence ID" value="ENSCJPP00005015725.1"/>
        <property type="gene ID" value="ENSCJPG00005012986.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107312422"/>
    <dbReference type="KEGG" id="cjo:107312422"/>
    <dbReference type="CTD" id="3777"/>
    <dbReference type="GeneTree" id="ENSGT00940000158248"/>
    <dbReference type="OrthoDB" id="297496at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005252">
        <property type="term" value="F:open rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044548">
        <property type="term" value="F:S100 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005272">
        <property type="term" value="F:sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071468">
        <property type="term" value="P:cellular response to acidic pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000057">
        <property type="entry name" value="Potassium channel subfamily K member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003092">
        <property type="entry name" value="2pore_dom_K_chnl_TASK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005406">
        <property type="entry name" value="KCNK3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF138">
        <property type="entry name" value="POTASSIUM CHANNEL SUBFAMILY K MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038061">
        <property type="entry name" value="K_channel_subfamily_K_type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01584">
        <property type="entry name" value="TASK1CHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01095">
        <property type="entry name" value="TASKCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11 13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 12 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0630">Potassium</keyword>
    <keyword evidence="6 12" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4 12" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="220"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="16">
        <location>
            <begin position="66"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="16">
        <location>
            <begin position="167"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="26"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR038061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="389" mass="43376" checksum="466151A213C700E5" modified="2022-01-19" version="1">MKRQNVRTLALILCTFTYLLVGAAVFDALESEEETAERRRLEAKSQELKNKYNLSAESYRELEWVVLKLKPHKAGVQWKFAGSFYFAITVITTIGYGHAAPSTDGGKVFCMVYALLGIPLTLVMFQSLGERINTFVRYLLHRIKKCLGMRRAEVSMANMVTIGFFSCISTLCIGAAAFSYYEHWSFFHAYYYCFITLTTIGFGDYVALQKDEALQNNPQYVAFSFVYILTGLTVIGAFLNLVVLRFMTMNAEDEKRDAEHRALLTRNGQASSVHTTDTASSAPTAVAAGGGGGGLRNVYAEVLHFQSMCSCLWYKSREKLQYSIPMIIPRDLSTSDTCVEQSHSSPGRCPETPSNRCFCNARRSAISSVSTGLHSLSAFQGLMKRRSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TMH0</accession>
    <name>A0A8C2TMH0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">S-adenosylmethionine synthase</fullName>
            <ecNumber evidence="12">2.5.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC107306415</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the formation of S-adenosylmethionine from methionine and ATP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>L-methionine + ATP + H2O = S-adenosyl-L-methionine + phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="12">Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the AdoMet synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="12"/>
    <dbReference type="RefSeq" id="XP_015705045.1">
        <property type="nucleotide sequence ID" value="XM_015849559.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TMH0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005020612.1">
        <property type="protein sequence ID" value="ENSCJPP00005014487.1"/>
        <property type="gene ID" value="ENSCJPG00005012082.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107306415"/>
    <dbReference type="KEGG" id="cjo:107306415"/>
    <dbReference type="GeneTree" id="ENSGT00950000183185"/>
    <dbReference type="OrthoDB" id="5852090at2759"/>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome Z"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18079">
        <property type="entry name" value="S-AdoMet_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000003">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000004">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000011">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00086">
        <property type="entry name" value="S_AdoMet_synth1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022631">
        <property type="entry name" value="ADOMET_SYNTHASE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01034">
        <property type="entry name" value="metK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="S-ADENOSYLMETHIONINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
        <property type="entry name" value="S-AdoMet_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000497">
        <property type="entry name" value="MAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="S-adenosylmethionine synthetase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00376">
        <property type="entry name" value="ADOMET_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00377">
        <property type="entry name" value="ADOMET_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 12" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="10 12" id="KW-0630">Potassium</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S-adenosylmethionine synthetase N-terminal" evidence="14">
        <location>
            <begin position="12"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase central" evidence="15">
        <location>
            <begin position="123"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase C-terminal" evidence="16">
        <location>
            <begin position="247"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005014487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="389" mass="43237" checksum="FEC3CA9DD4AEF43A" modified="2022-01-19" version="1">MSSHTSKKEKRFLFTSESVAEGHSDKMCDQISDAVLDAHLSIDPDAKVACECVAKTGMILLCGEITSRAIVDYQQIVRETLKRIGYDDSSKGLDHKTCTVLVALEQQCKEIKHAVSHGKSDDDIGAGDQGLMFGYATDETEECMPLTILLAHKLTARIKDLERNGTWPWVRPDGKTQVTMEYKESDGAVEPIRVHTVVISVHHAPDVPLQHIQKELMEKVVKEVIPEKYLDEGTIYHLLPSEKFVEGGPKSDAGLTGRKIIVDTYGGWGAHGGGAFSGKDPSKVDRSAAYAARWVAKSLVKAGLCKRVLIQLSYAIGLSHPLAISVFHYGTSDRSEEELLEIVQKNFDLRLGAIIRELDLKRPIYQKTACYGHFGREEFTWEIPKKLVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TN35</accession>
    <name>A0A8C2TN35_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Neural EGFL like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">NELL2</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015710374.1">
        <property type="nucleotide sequence ID" value="XM_015854888.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TN35"/>
    <dbReference type="Ensembl" id="ENSCJPT00005022943.1">
        <property type="protein sequence ID" value="ENSCJPP00005016303.1"/>
        <property type="gene ID" value="ENSCJPG00005013414.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107309796"/>
    <dbReference type="KEGG" id="cjo:107309796"/>
    <dbReference type="CTD" id="4753"/>
    <dbReference type="GeneTree" id="ENSGT00810000125439"/>
    <dbReference type="OrthoDB" id="6516201at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
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        <property type="term" value="P:commissural neuron axon guidance"/>
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        <property type="entry name" value="Neural EGFL like 2"/>
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        <property type="entry name" value="Protein kinase C-binding protein NELL1"/>
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        <property type="entry name" value="Protein kinase C-binding protein NELL1"/>
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        <property type="entry name" value="protein kinase C-binding protein NELL1"/>
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        <property type="entry name" value="Protein kinase C-binding protein NELL2"/>
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        <property type="entry name" value="Protein kinase C-binding protein NELL2"/>
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        <property type="entry name" value="protein kinase C-binding protein NELL2"/>
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        <property type="entry name" value="Complement Module, domain 1"/>
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        <property type="entry name" value="Laminin"/>
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        <property type="entry name" value="ConA-like_dom_sf"/>
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        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
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        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
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        <property type="entry name" value="EGF_Ca-bd_CS"/>
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        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
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        <property type="entry name" value="Laminin_G"/>
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        <property type="entry name" value="NELL2-like_EGF"/>
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        <property type="entry name" value="NOTCH1_EGF-like"/>
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        <property type="entry name" value="PKC-binding_NELL"/>
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        <property type="entry name" value="TSPN-like_N"/>
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        <property type="entry name" value="VWF_dom"/>
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        <property type="entry name" value="NEL HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24042:SF0">
        <property type="entry name" value="PROTEIN KINASE C-BINDING PROTEIN NELL2"/>
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        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
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        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="VWC"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="EGF"/>
        <property type="match status" value="6"/>
    </dbReference>
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        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="5"/>
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        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00210">
        <property type="entry name" value="TSPN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="VWC"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="VWC_out"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="FnI-like domain"/>
        <property type="match status" value="3"/>
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        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="EGF_2"/>
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        <property type="match status" value="6"/>
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        <property type="entry name" value="VWFC_1"/>
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        <property type="entry name" value="VWFC_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 7" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034479323" evidence="9">
        <location>
            <begin position="22"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="11">
        <location>
            <begin position="272"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="397"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="440"/>
            <end position="481"/>
        </location>
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    <feature type="domain" description="EGF-like" evidence="10">
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            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="523"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="555"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="602"/>
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        </location>
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        <location>
            <begin position="638"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="11">
        <location>
            <begin position="698"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="241"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="525"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="543"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
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        </source>
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    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50184"/>
        </source>
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    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005016303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="816" mass="90930" checksum="C867F9F9AE0A17F5" modified="2022-01-19" version="1">MESGCGLGTLCLLLCLGPVVGFGVDPSLQIDVLSELGLPGSAAGVRQVPGLHNGSKAFLFPDISRSVKASPETAEIFFQKLRNKYEFTILVTLKQAHLNSGVIFSVHHLDHRYLELESSGHRNEIRLHYRTGSHRSHTEVFPYILADDKWHRLSLAISASHLILHVDCNKIYERVVEKPFMDLPLGTTFWLGQRNNAHGYFKGIMQDVQLLVMPQGFISQCPDLNRTCPTCNDFHGLVQKIMELQDILAKTSAKLSQAEQRMNKLDQCYCERTCTMKGMTYREFESWTDGCKNCTCMNGTVQCEALICPLSDCPHNSALAYVDGKCCKECQSVCIFEGRTYFEGQRETVYSSSGDCVLFECKDHKMQRIPKDSCPPLNCPESQQIPLSHSCCKICKGHDFCTEGHNCMEHSVCRNLDDRAVCSCRDGFRALREDNAYCEDINECAEGQHYCRENTMCVNTPGSFMCICKTGFIRIDDYSCTEHDECVTNQHNCDENALCFNTVGGHNCVCKLGYTGNGTVCKAFCKDGCRNGGACIASNVCACPQGFTGPSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECATGRHSCANDTVCFNLDGGYDCRCPHGKNCTGDCIHEDKIKHNGQIWVLENDRCSVCSCQSGYVMCRRMVCDCENPTVDLFCCPECDPRLSSQCLHQSGEISYNSGDSWIQNCQQCRCLQGEVDCWPLPCPDVDCEFSVLPENECCPRCVSDPCQADTIRNDITKTCLDETNVVRFTGSSWIKHGTECTLCQCKNGHVCCSVDPQCLQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TNP8</accession>
    <name>A0A8C2TNP8_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Zic family member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ZIC1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GLI C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015727421.1">
        <property type="nucleotide sequence ID" value="XM_015871935.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TNP8"/>
    <dbReference type="SMR" id="A0A8C2TNP8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005021275.1">
        <property type="protein sequence ID" value="ENSCJPP00005014979.1"/>
        <property type="gene ID" value="ENSCJPG00005012452.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107318288"/>
    <dbReference type="KEGG" id="cjo:107318288"/>
    <dbReference type="CTD" id="7545"/>
    <dbReference type="GeneTree" id="ENSGT00940000160269"/>
    <dbReference type="OrthoDB" id="3214149at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007628">
        <property type="term" value="P:adult walking behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098727">
        <property type="term" value="P:maintenance of cell number"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021772">
        <property type="term" value="P:olfactory bulb development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007389">
        <property type="term" value="P:pattern specification process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042307">
        <property type="term" value="P:positive regulation of protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008589">
        <property type="term" value="P:regulation of smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021510">
        <property type="term" value="P:spinal cord development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000035">
        <property type="entry name" value="Zinc finger protein ZIC 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000039">
        <property type="entry name" value="Zinc finger protein ZIC 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000041">
        <property type="entry name" value="Zinc finger protein ZIC 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001330">
        <property type="entry name" value="Zinc finger protein ZIC 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043359">
        <property type="entry name" value="GLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056436">
        <property type="entry name" value="Znf-C2H2_ZIC1-5/GLI1-3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041643">
        <property type="entry name" value="Znf_ZIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718:SF4">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23561">
        <property type="entry name" value="zf-C2H2_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18366">
        <property type="entry name" value="zf_ZIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="271"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="299"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="329"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="359"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="372"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="383"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005014979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="444" mass="48223" checksum="D5090199096D6981" modified="2022-01-19" version="1">MLLDAGPQYPAIGVTTFGSSRHHSAADVTDREVGLGINPFADGMGAFKLNPGGHELASAGQTAFTSQAPGYAAALGHHHHPPHVGSYSSAAFNSTRDFLFRNRGFGEAAAASAQHSLFASAAGGFGGPHGHGDAAGHILFPGLHEQAAGHASPNVVNGQMRLGFSGDMYGRAEQYGQVTSPRSEHYASSQLHGYGHMNMNMAAHHGAGAFFRYMRQPIKQELICKWIEPEQLANPKKSCNKTFSTMHELVTHVTVEHVGGPEQSNHICFWEECPREGKPFKAKYKLVNHIRVHTGEKPFPCPFPGCGKVFARSENLKIHKRTHTGEKPFKCEFEGCDRRFANSSDRKKHMHVHTSDKPYLCKMCDKSYTHPSSLRKHMKVHESSSQGSQPSPAASSGYESSTPPTIVSPSTENQTASSLSPSSSAVHHTSSHSTLTSNFNEWYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TP13</accession>
    <name>A0A8C2TP13_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">2-oxoglutarate dehydrogenase-like, mitochondrial</fullName>
            <ecNumber evidence="5">1.2.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">2-oxoglutarate dehydrogenase complex component E1-like</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Alpha-ketoglutarate dehydrogenase-like</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">OGDHL</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">2-oxoglutarate dehydrogenase (E1-like) component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDHC) which mediates the decarboxylation of alpha-ketoglutarate in the tricarboxylic acid cycle. The OGDHC complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) while reducing NAD(+) to NADH. The OGDHC complex is mainly active in the mitochondrion. Involved in the inhibition of cell proliferation and in apoptosis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 2-oxoglutarate + H(+) = N(6)-[(R)-S(8)-succinyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:12188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:20092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83120"/>
            <dbReference type="EC" id="1.2.4.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:12189"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the alpha-ketoglutarate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.2" evidence="5"/>
    <dbReference type="RefSeq" id="XP_015721549.1">
        <property type="nucleotide sequence ID" value="XM_015866063.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015721550.1">
        <property type="nucleotide sequence ID" value="XM_015866064.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015721551.1">
        <property type="nucleotide sequence ID" value="XM_015866065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TP13"/>
    <dbReference type="Ensembl" id="ENSCJPT00005021493.1">
        <property type="protein sequence ID" value="ENSCJPP00005015135.1"/>
        <property type="gene ID" value="ENSCJPG00005012575.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107315569"/>
    <dbReference type="KEGG" id="cjo:107315569"/>
    <dbReference type="CTD" id="55753"/>
    <dbReference type="GeneTree" id="ENSGT00950000183125"/>
    <dbReference type="OrthoDB" id="413077at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004591">
        <property type="term" value="F:oxoglutarate dehydrogenase (succinyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02016">
        <property type="entry name" value="TPP_E1_OGDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000002">
        <property type="entry name" value="2-oxoglutarate dehydrogenase, E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1150:FF:000001">
        <property type="entry name" value="2-oxoglutarate dehydrogenase, mitochondrial isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12470:FF:000001">
        <property type="entry name" value="2-oxoglutarate dehydrogenase, mitochondrial isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11610">
        <property type="entry name" value="Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1150">
        <property type="entry name" value="TPP helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032106">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011603">
        <property type="entry name" value="2oxoglutarate_DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042179">
        <property type="entry name" value="KGD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031717">
        <property type="entry name" value="ODO-1/KGD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00239">
        <property type="entry name" value="2oxo_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006914">
        <property type="entry name" value="PRK09404.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008907">
        <property type="entry name" value="PRK12270.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152">
        <property type="entry name" value="2-OXOGLUTARATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152:SF5">
        <property type="entry name" value="2-OXOGLUTARATE DEHYDROGENASE-LIKE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16078">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16870">
        <property type="entry name" value="OxoGdeHyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000157">
        <property type="entry name" value="Oxoglu_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="13" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="19">
        <location>
            <begin position="642"/>
            <end position="855"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00051042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00059442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00068875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00077399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00079737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1014" mass="115544" checksum="A39DED70AE84DBE5" modified="2022-01-19" version="1">MSHLKLFAAMVKWHGIKTLRKPDVTGRVFSHGRRYVSSGSSEPFLSGSNSSYVEEMYYAWLENPQSVHKSWDLFFRNANAGQTCDPHLPDQLERKASFLQSQGLAQTPGKAEKVVEDHLAVQSLIRAYQIRGHHVAQLDPLGILDADLDSFVPSDLITTIDKLGFYGLHESDLDKVFQLPTTTFIGGNENSLSLREIIRRLENTYCQHIGLEFMFINDVEQCQWIRQKFETPGVMKFTNEEKRTLLARLVRSMRFEDFLARKWSSEKRFGLEGCEVMIPALKTIIDKSSEMGIEYVIMGMPHRGRLNVLANVIRKELEQIFCQFDPKLEAADEGSGDVKYHLGMYHERINRTTNKKITLSLMANPSHLEAVDPVVQGKTKAEQFYRGDTAGKKVMSILLHGDAAFAGQGVVYETFHLSDLPSYTTNGTIHVVVNNQIGFTTDPRMARSSPYPTDVARVVNAPIFHVNADDPEAVMYVCSVAAEWRNTFNKDVVVDLVCYRRRGHNEMDEPMFTQPLMYKQIHKQVPVLKKYADKLIADGTVTLQEFEEEIAKYDRICEEAYTRSKDNKILHIKHWLDSPWPGFFNVDGEPKSMSCPPTGISEDLLTHIGNVASSVPVKDFKIHAGLSRILKARSEMTKNRVVDWALAEYMAFGSFLKEGIHVRLSGQDVERGTFSHRHHVLHDQEVDKRTCVPMNHLWEQQAPYTVCNSSLSEYGVLGFELGFAMASPNALVCWEAQFGDFHNTAQCIIDQFISSGQAKWVRHNGIVLLLPHGMEGMGPEHSSARPERFLQMSNDDPDAYPELTEQFEVSQLYECNWIVVNCSTPANYFHVLRRQILLPFRKPLIVLTPKSLLRHPEAKSSFDEMVSGTTFQRVIPENGLAAQAPHEVKRVIFCTGKVYYDLVKERKNQDLEKQVAITRLEQISPFPFDLLKEELEKYPGADLVWCQEEHKNSGYYDYVKPRFRTIVNHTRPIWYVGREPAAAAATGNKNTHLVSLRRFLDTAFNLEAFEGKTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TP18</accession>
    <name>A0A8C2TP18_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATP-binding cassette sub-family F member 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ABCF3</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015727204.1">
        <property type="nucleotide sequence ID" value="XM_015871718.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TP18"/>
    <dbReference type="Ensembl" id="ENSCJPT00005023471.1">
        <property type="protein sequence ID" value="ENSCJPP00005016753.1"/>
        <property type="gene ID" value="ENSCJPG00005013744.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107318191"/>
    <dbReference type="KEGG" id="cjo:107318191"/>
    <dbReference type="CTD" id="55324"/>
    <dbReference type="GeneTree" id="ENSGT00940000155604"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000104">
        <property type="entry name" value="ATP-binding cassette sub-family F member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000688">
        <property type="entry name" value="ATP-binding cassette sub-family F member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058770">
        <property type="entry name" value="PWI_ABCF3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF117">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26051">
        <property type="entry name" value="PWI_ABCF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="180"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="494"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="132"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="132"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="163"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00073919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005016753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="711" mass="80198" checksum="699BE1AEDA999164" modified="2022-01-19" version="1">MASCSDILRTEFPELDGEVFAYVTGILHSSGADFESVDELVEAVGELLQEVARDGKDESAIRDVCQRLFNCLQLDEARAQRCSQVLLDAPIQLSQITDGYDANTDLLPGLLLKRGQTSMVNAKKLEKAEAKLKAKQDKRMERDSVKSSSPLVLEEATASQAASKKETRMESSGKNKSYDVRIENFDVSFGERVLLAGADLNLAFGRRYGLVGRNGLGKTTLLKMIASRSLRIPSHISILHVEQEVAGDETPALQSVLECDTTRESLLREEKELTAKVNAGRGEGTEGTRLSEIYAKLEEIEADKAPARASVILAGLGFNTKMQQQTTKEFSGGWRMRLALARALFARPDLLLLDEPTNMLDVRAILWLENYLQTWQSTILVVSHDRNFLNTVATDIIHLHSQRLDTYRGDFENFMKTKEERLKNQQREYEAQQQYREHIQVFIDRFRYNANRASQVQSKLKLLEKLPELKPVDKESEVMMKFPDGFEKFSPPILQLDEVDFCYDPSHYIFRSLSVSADLESRICVVGENGAGKSTMLKILMGELAPVRGIRHAHRNLKIGYFSQHHVDQLDLNISAVELLARKFPGKTEEEYRHQLGSYGVSGELAVRPVASLSGGQKSRVAFAQMTMSCPNFYILDEPTNHLDMETIEALAKALNKFRGGIILVSHDECFIRLVCHELWVCENATVTRIEGGFDQYRDILKEQFRKEGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TP93</accession>
    <name>A0A8C2TP93_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Calpastatin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Calpain inhibitor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">CAST</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protease inhibitor I27 (calpastatin) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TP93"/>
    <dbReference type="Ensembl" id="ENSCJPT00005021804.1">
        <property type="protein sequence ID" value="ENSCJPP00005015360.1"/>
        <property type="gene ID" value="ENSCJPG00005012754.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000002993"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome Z"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010859">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000675">
        <property type="term" value="P:negative regulation of type B pancreatic cell apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990709">
        <property type="term" value="P:presynaptic active zone organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026998">
        <property type="entry name" value="Calpastatin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001259">
        <property type="entry name" value="Prot_inh_calpain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10077">
        <property type="entry name" value="CALPASTATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10077:SF0">
        <property type="entry name" value="CALPASTATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00748">
        <property type="entry name" value="Calpain_inhib"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0789">Thiol protease inhibitor</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="239"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="76"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="121"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="278"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="348"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="421"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="451"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="479"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="519"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="581"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="620"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="757" mass="80229" checksum="CBBC0E29FA822542" modified="2022-01-19" version="1">MSQPGSGPPGPAAQSDKKANGTSSKSGEKKEATEKSASANVSQPPKMQTSGASSAAKKQSPSADASKTPIMKPSEAKSTPTIQTEPEKTAQSTKPSVSQSNQPTAEKQKESSDAKIAPSLVTASKPNNTGKETTGQAERPSQATSADTAQPKTEKTSTAGVAVASVVAAADKPNTEPAMDESALDSLIDTLGGSEEDVATRPVYTGREITENITSEYLEELGKREGSLPPDYLALLKSKVDGKDGGLPKADEPSEKPMTDDELADALSSDFTCSTAATEEKKTTEKQNKEGEIIQAQVASSMKTSVPPKEKKTKSKEEIKEDAMEALMATIGGPEPEPEPKGPIVEVSEAKAKEKKEKKAGEHDDTIPPDYRLKPELDKDGKPVIPKLEEKPKPLSESDLVDEFSKDFASPAQPAVESKPSKPSSTSKKPSAPASGKTAKDEVVPRATACSVQSSAPTSASSVGHEADEALEALSSSLGKKEPDPAEKKPAVDKVKEKNKQKEHKKLGEDEETIPPDYRLTDAKDKDGRPLLKKPEEESQPMSENDLLEGLTKGFSPAQSAPVPTQTVKKKSKTGKKTADSSDVISASTVSSVHSAAPLASTSGGKEMDDALDLLSDSLGQREPDPDENKPVVDKVKEKAKSEHRDKLGERDDTIPPDYKKLLESSDKGKPVKPAPKDASKNKEQKKPTDDSAAIDALSDDFDSSPKTSATPQHSKEKSGKETVTTKATSKDERKPKDHKKARGQSSSSKSEKQKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TQI9</accession>
    <name>A0A8C2TQI9_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Lipase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC107315628</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TQI9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005022187.1">
        <property type="protein sequence ID" value="ENSCJPP00005015685.1"/>
        <property type="gene ID" value="ENSCJPG00005012956.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156860"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000012">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006693">
        <property type="entry name" value="AB_hydrolase_lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025483">
        <property type="entry name" value="Lipase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04083">
        <property type="entry name" value="Abhydro_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000862">
        <property type="entry name" value="Steryl_ester_lip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034055720" description="Lipase" evidence="4">
        <location>
            <begin position="36"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Partial AB-hydrolase lipase" evidence="5">
        <location>
            <begin position="44"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="341"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR000862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000862-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="395" mass="45163" checksum="5B712176480366F2" modified="2022-01-19" version="1">NVSSVRHVGDILQRTMMWLFITVTYLICTTDSSSASPEVSMDVGEIVRYHGYPYEEHEVVTEDGYYLTLQRIPHGRDNSESTTPKPAVLLQHGLVLEGSNWVTNLPNRSLGFILADAGYDVWIGNSRGNSWSRKHKEFEFYSEKYSSYSFHEMAMYDLPATINYILQKTGQEQLYYVAYSQGTTTGFIAFSSIPELDHKIKMFFALAPITTSSNMKSPLVRVFDLPEGLIKVGSPLTLLWFHRQNLFLKQVTSRLCGYTFFKSFCSLVLYLPGGFTNSLNVVRILQITQCGCAVGKRTVSWSHQLLDMGQTAMLFIFQSTPPFYELENMKAPLAAWFGGRDWISAPEDVNITLPRITNVAYKKYIPEFVHFDFLWGVQAYEQIYKEMLELMKKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TRE0</accession>
    <name>A0A8C2TRE0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sulfotransferase</fullName>
            <ecNumber evidence="11">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">CHST1</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="11"/>
    <dbReference type="RefSeq" id="XP_015719941.1">
        <property type="nucleotide sequence ID" value="XM_015864455.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015719942.1">
        <property type="nucleotide sequence ID" value="XM_015864456.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TRE0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005024475.1">
        <property type="protein sequence ID" value="ENSCJPP00005017587.1"/>
        <property type="gene ID" value="ENSCJPG00005014319.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107314790"/>
    <dbReference type="KEGG" id="cjo:107314790"/>
    <dbReference type="CTD" id="8534"/>
    <dbReference type="GeneTree" id="ENSGT00940000161262"/>
    <dbReference type="OrthoDB" id="6138663at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045130">
        <property type="term" value="F:keratan sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001517">
        <property type="term" value="F:N-acetylglucosamine 6-O-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018146">
        <property type="term" value="P:keratan sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016469">
        <property type="entry name" value="Carbohydrate_sulfotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051135">
        <property type="entry name" value="Gal/GlcNAc/GalNAc_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10704">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10704:SF36">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005883">
        <property type="entry name" value="Carbohydrate_sulfotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034697905" description="Sulfotransferase" evidence="12">
        <location>
            <begin position="24"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfotransferase" evidence="13">
        <location>
            <begin position="68"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005017587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="418" mass="47817" checksum="8EBEF27CBA292ACE" modified="2022-01-19" version="1">MQCSWKAVLLLALASIAIQYTAIRTFTAKSFHSCPIPVNCSLSQDADAAERLCDESPTFTYNLSTRKTHVLILATTRSGSSFVGQLFNQHFDVFYLFEPLYHVQYTLIPKLTQSKSTTDRRVMLGASRDLLRSLYDCDLYFLENYIKPQPINHTTDRLFRRGASKALCSPPVCEALGAVDLHLEEGDCVKKCGTLNLTLATESCREHGHVAIKTVRVPEVNDLRALVEDPRLNLKVIQLVRDPRGILASRSETFRDTYRLWRIWDGTGRKPYNLDVTQLTTVCEDFWNSVSTGLNRPPWLKGKYMLVRYEDLAKNPMKKTEEIYDFLGIPMDGNVERWIQNNTRGDRSSSKHKYGTVRNSAATAEKWRFRLSYEIVAFTQRACQQVLAQLGYRAARSEEELKNLSISLVEERDFLPFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TSP5</accession>
    <name>A0A8C2TSP5_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Spastin</fullName>
            <ecNumber evidence="16">5.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16 22" type="primary">SPAST</name>
        <name evidence="16" type="synonym">SPG4</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Required for membrane traffic from the endoplasmic reticulum (ER) to the Golgi and for completion of the abscission stage of cytokinesis. Also plays a role in axon growth and the formation of axonal branches.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers.</text>
            <dbReference type="EC" id="5.6.1.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="16">Homohexamer. The homohexamer is stabilized by ATP-binding. The homohexamer may adopt a ring conformation through which microtubules pass prior to being severed. Interacts with microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Axon</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Membrane</location>
            <topology evidence="16">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Cytoplasm</location>
            <location evidence="16">Cytoskeleton</location>
            <location evidence="16">Microtubule organizing center</location>
            <location evidence="16">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Cytoplasm</location>
            <location evidence="16">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Cytoplasm</location>
            <location evidence="16">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Nucleus</location>
        </subcellularLocation>
        <text evidence="16">Forms an intramembrane hairpin-like structure in the membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the AAA ATPase family. Spastin subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.1" evidence="16"/>
    <dbReference type="RefSeq" id="XP_015713089.1">
        <property type="nucleotide sequence ID" value="XM_015857603.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TSP5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005023544.1">
        <property type="protein sequence ID" value="ENSCJPP00005016817.1"/>
        <property type="gene ID" value="ENSCJPG00005013634.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107311250"/>
    <dbReference type="KEGG" id="cjo:107311250"/>
    <dbReference type="CTD" id="6683"/>
    <dbReference type="GeneTree" id="ENSGT00940000156258"/>
    <dbReference type="OrthoDB" id="10251136at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904115">
        <property type="term" value="C:axon cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043014">
        <property type="term" value="F:alpha-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008568">
        <property type="term" value="F:microtubule severing ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008089">
        <property type="term" value="P:anterograde axonal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019896">
        <property type="term" value="P:axonal transport of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007409">
        <property type="term" value="P:axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032506">
        <property type="term" value="P:cytokinetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010458">
        <property type="term" value="P:exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090148">
        <property type="term" value="P:membrane fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001578">
        <property type="term" value="P:microtubule bundle formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051013">
        <property type="term" value="P:microtubule severing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051228">
        <property type="term" value="P:mitotic spindle disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031468">
        <property type="term" value="P:nuclear membrane reassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032467">
        <property type="term" value="P:positive regulation of cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031117">
        <property type="term" value="P:positive regulation of microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034214">
        <property type="term" value="P:protein hexamerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd02679">
        <property type="entry name" value="MIT_spastin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19524">
        <property type="entry name" value="RecA-like_spastin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000093">
        <property type="entry name" value="Fidgetin-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000036">
        <property type="entry name" value="Spastin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.80:FF:000006">
        <property type="entry name" value="Spastin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03021">
        <property type="entry name" value="Spastin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007330">
        <property type="entry name" value="MIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017179">
        <property type="entry name" value="Spastin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035106">
        <property type="entry name" value="Spastin_chordate"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF86">
        <property type="entry name" value="SPASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037338">
        <property type="entry name" value="Spastin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00745">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14 16" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 16" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 16" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 16" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="2 16" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7 16" id="KW-0221">Differentiation</keyword>
    <keyword evidence="12 16" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10 16 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 16" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9 16" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="6 16 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="topological domain" description="Cytoplasmic" evidence="16">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="intramembrane region" description="Helical" evidence="16">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="16">
        <location>
            <begin position="83"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="MIT" evidence="21">
        <location>
            <begin position="113"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="20">
        <location>
            <begin position="371"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="224"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="18">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="264"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="379"/>
            <end position="386"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00036378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005016817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="613" mass="66263" checksum="16BF932068C8E6BE" modified="2022-01-19" version="1">MNSPGGKGKKKGSAGSSSAPPAAGASPSAPSGPAPPAPPAGAAAAAAASPHKRNLYYFSYPLFAAFALLRFVAFQLGLLVAWLCERLSRGALMASKSSRAGDAPEPGGAAERVRACHKRAFECISMALRIDEDERAGQKEQAVEWYKKGIEELERGIAVLVVGQGDQCDRARRLQSKMKTNLAMAKDRLQLLEKLQADLQISKPQMEVYNDSTNLACRNGHLQSESGAVPKKKDPLTHTSNSLPRSKTVAKTGSTGLSGHHRTPSYSGISTASVSRPAANPATSTHKAPPKNSRTNKPSTPTPAARKKKDMKVFRNVDSNLANLILNEIVDSGPAVKFDDIAGQELAKQALQEIVILPSLRPELFTGLRAPARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSIIFIDEVDSLLCERREGEHDASRRLKTEFLIEFDGVQSSGEDRILVMGATNRPQELDDAVLRRFIKRVYVSLPNEETRLILLKNLLSKQGSPLTQKELAQLARMTDGYSGSDLTALAKDAALGPIRELKPEQVKNMSASEMRNIKLSDFTESLKKIKRSLSPQTLEAYVRWNKDFGDTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TSU7</accession>
    <name>A0A8C2TSU7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ribulose-phosphate 3-epimerase</fullName>
            <ecNumber evidence="8">5.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">RPE</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-ribulose 5-phosphate = D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13677"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="EC" id="5.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ribulose-phosphate 3-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.1" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2TSU7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005023618.1">
        <property type="protein sequence ID" value="ENSCJPP00005016886.1"/>
        <property type="gene ID" value="ENSCJPG00005013838.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000001447"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004750">
        <property type="term" value="F:D-ribulose-phosphate 3-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00429">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000191">
        <property type="entry name" value="ribulose-phosphate 3-epimerase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02227">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026019">
        <property type="entry name" value="Ribul_P_3_epim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000056">
        <property type="entry name" value="Ribul_P_3_epim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004076">
        <property type="entry name" value="PRK05581.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11749">
        <property type="entry name" value="RIBULOSE-5-PHOSPHATE-3-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00834">
        <property type="entry name" value="Ribul_P_3_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01085">
        <property type="entry name" value="RIBUL_P_3_EPIMER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01086">
        <property type="entry name" value="RIBUL_P_3_EPIMER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="15" id="KW-0170">Cobalt</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00057323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005016886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="243" mass="26729" checksum="20071130FDE71AED" modified="2022-01-19" version="1">MASGCRIGPSILNSDLAALGAECSRMLDCGADYLHLDVMDGHFVPNITFGHPVVESLRKRLGQEPFFDMHMMVARPEQWVQPMAVAGANQYTFHLEATDGPGALIKDIRENGMKVGLAIKPGTSVEQLAPWANQIDMALVMTVEPGFGGQKFMEDMMPKVQWLRTQFPSLDIEVDGGVGPDTIHKCAEVRGCGLRSGASLPRETGRTRSRLLMLCGQRGWQRRHRVGLSSCLVSQWLLKPLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TTR7</accession>
    <name>A0A8C2TTR7_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Keratin-associated protein 6-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">LOC107324400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015739866.1">
        <property type="nucleotide sequence ID" value="XM_015884380.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TTR7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005024061.1">
        <property type="protein sequence ID" value="ENSCJPP00005017234.1"/>
        <property type="gene ID" value="ENSCJPG00005014095.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107324400"/>
    <dbReference type="KEGG" id="cjo:107324400"/>
    <dbReference type="GeneTree" id="ENSGT01030000235366"/>
    <dbReference type="OrthoDB" id="9118337at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005017234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="90" mass="10622" checksum="326E30A25740B385" modified="2022-01-19" version="1">MTFYYQNQWDDSCYSPCSYGSVYSYRTYDCGSPCGYRSYDCGIPCGYRGSWGLSGYRDCYPSYSSRCYSPCYTRYTRRYSLGSCYPCYNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TU26</accession>
    <name>A0A8C2TU26_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SH2 domain-containing adapter protein E</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">SHE</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TU26"/>
    <dbReference type="Ensembl" id="ENSCJPT00005024230.1">
        <property type="protein sequence ID" value="ENSCJPP00005017378.1"/>
        <property type="gene ID" value="ENSCJPG00005014195.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159107"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001784">
        <property type="term" value="F:phosphotyrosine residue binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000067">
        <property type="entry name" value="Src homology 2 domain-containing E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051846">
        <property type="entry name" value="SH2_domain_adapters"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15127">
        <property type="entry name" value="HEAVYWEIGHT, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15127:SF29">
        <property type="entry name" value="SH2 DOMAIN-CONTAINING ADAPTER PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="SH2" evidence="6">
        <location>
            <begin position="332"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="287"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="175"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="287"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00074793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005017378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="432" mass="47061" checksum="D95885E543A0223B" modified="2022-01-19" version="1">LTRPPPDGDPSCRPPLLRAEPPRREFPSNLRTGSEKARPNKPGGTARKSLGGTEPPGGAPPGKSRKNSAAEVGGCRAVHPPGAGKDGGGRLSRDNLQGLLQAAAGRMRKNSKVEGVASEGPPRSCGTYINRLIKVEAHEKNPKGYPSAGPVPEEKGKSPKTETVIILEDYADPYDAKRTKGQRDAERLGENDGYMEPYDAQQMITEVRRRGSKDPLVKALLMLDEAGGKAEVAKKVVGGSEAVGRGPQLYDTPYEPGADERPAAEYEQPWEWKKEQIVKALSVQFEGSERPREEAARQHLRQKSWTPRMVKPSEQSEGERVDPAVSLEKQPWYHGAITRAEAESRLQACKEAGYLVRTSESGSGKYSIALKTSQGCVHILVAETKDHKYTLSQSSGGFASVPEVVHYYSTEKLPFKGAEHMALLHPVHCKTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TV21</accession>
    <name>A0A8C2TV21_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cellular retinoic acid binding protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">CRABP2</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015739989.1">
        <property type="nucleotide sequence ID" value="XM_015884503.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TV21"/>
    <dbReference type="Ensembl" id="ENSCJPT00005023893.1">
        <property type="protein sequence ID" value="ENSCJPP00005017100.1"/>
        <property type="gene ID" value="ENSCJPG00005013995.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107324468"/>
    <dbReference type="KEGG" id="cjo:107324468"/>
    <dbReference type="CTD" id="1382"/>
    <dbReference type="GeneTree" id="ENSGT00940000157619"/>
    <dbReference type="OrthoDB" id="195110at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001972">
        <property type="term" value="F:retinoic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035115">
        <property type="term" value="P:embryonic forelimb morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048672">
        <property type="term" value="P:positive regulation of collateral sprouting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042573">
        <property type="term" value="P:retinoic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd19461">
        <property type="entry name" value="CRABP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.128.20:FF:000001">
        <property type="entry name" value="Fatty acid-binding protein, adipocyte"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000463">
        <property type="entry name" value="Fatty_acid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031259">
        <property type="entry name" value="ILBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000566">
        <property type="entry name" value="Lipocln_cytosolic_FA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11955">
        <property type="entry name" value="FATTY ACID BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00061">
        <property type="entry name" value="Lipocalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00178">
        <property type="entry name" value="FATTYACIDBP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00214">
        <property type="entry name" value="FABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytosolic fatty-acid binding proteins" evidence="4">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005017100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="178" mass="19691" checksum="0E1B1B06361357BB" modified="2022-01-19" version="1">MPNFSGNWKMKSSENFEELLKALGVNMMLRKIAVAAASKPAVEIKQDGESFYIKTSTTVRTTEISFRIGEEFEEQTVDGRPCKSLAKWESENKMVCEQRLLKGEGPRTGWSRELTNDGELILTMTADDVVCTRVYIRSDTTNHHPTTAPFPPPPTPHFSHGPVSPCPPVAASCPPPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TVQ9</accession>
    <name>A0A8C2TVQ9_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TVQ9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005025207.1">
        <property type="protein sequence ID" value="ENSCJPP00005018110.1"/>
        <property type="gene ID" value="ENSCJPG00005014746.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000239461"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005018110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="56" mass="5873" checksum="6516674D85138F6E" modified="2022-01-19" version="1">MGNGMSKVLRAGLSVLLADSEDRDSLRRHGVTHILSVHNGAKPVLEVSAGHGTVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TXM3</accession>
    <name>A0A8C2TXM3_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Coagulation factor IX-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC107317866</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TXM3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005027885.1">
        <property type="protein sequence ID" value="ENSCJPP00005020216.1"/>
        <property type="gene ID" value="ENSCJPG00005016291.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000165072"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007596">
        <property type="term" value="P:blood coagulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000012">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000068">
        <property type="entry name" value="transmembrane protease serine 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.740.10:FF:000001">
        <property type="entry name" value="vitamin K-dependent protein S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.740.10">
        <property type="entry name" value="Coagulation Factor IX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017857">
        <property type="entry name" value="Coagulation_fac-like_Gla_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035972">
        <property type="entry name" value="GLA-like_dom_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000294">
        <property type="entry name" value="GLA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012224">
        <property type="entry name" value="Pept_S1A_FX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050442">
        <property type="entry name" value="Peptidase_S1_coag_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24278">
        <property type="entry name" value="COAGULATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24278:SF25">
        <property type="entry name" value="COAGULATION FACTOR IX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14670">
        <property type="entry name" value="FXa_inhibition"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00594">
        <property type="entry name" value="Gla"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001143">
        <property type="entry name" value="Factor_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00001">
        <property type="entry name" value="GLABLOOD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00069">
        <property type="entry name" value="GLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57630">
        <property type="entry name" value="GLA-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50998">
        <property type="entry name" value="GLA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 9" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Gla" evidence="13">
        <location>
            <begin position="33"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="78"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="12">
        <location>
            <begin position="226"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="177"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="177"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="411"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001143-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005020216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="472" mass="52184" checksum="2F6AEC60B2B48D12" modified="2022-01-19" version="1">SSSVDLLRVFCSLQAQLFMRKDAAHEVLRVHKRANYFLEEILPGNLERECNEEKCSFEEAKEIFHSQEKTTPFCCSLGLNPCTTNPCKNGGVCKIRRYSYFCICPPKFGGENCEKEKLECWYKNGGCGQYCWDSGSLQVQCSCAKGYTLHEDGKKCVQAAPFPCGLIRARRALEEVRHESTGRNRTGAELHAPGGVHESDRADGSGTAQHPLRNSGDPTELSQTRITGGTLCHRGQCPWQVLIRDSRDIGFCGGSLINSRWVITAAHFLSPAIQNTVPDNIDGEIPTEESTEQKIGVERSWIHPHYDSNNYNGDIALLYLSSEVVYNEFAIPICLPSPNLAALLAEEGQVGMVSGWGATHSRGSTLRFLMRVRLPVVSMETCQQSTSRLVTDNMFCAGYGTEAADACKGDSGGPFAVPYQNTWFLLGIVSWGDGCAERGKYGVYTRVSNYIPWIKETVESVADSEKFSINFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TXQ1</accession>
    <name>A0A8C2TXQ1_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tetraspanin 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TSPAN8</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TXQ1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005027490.1">
        <property type="protein sequence ID" value="ENSCJPP00005019889.1"/>
        <property type="gene ID" value="ENSCJPG00005016081.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158153"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF380">
        <property type="entry name" value="TETRASPANIN-8"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tetraspanin"/>
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    </dbReference>
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        <property type="entry name" value="Tetraspanin"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034918250" evidence="6">
        <location>
            <begin position="20"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005019889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="160" mass="18153" checksum="FABD14A8188E5694" modified="2022-01-19" version="1">MLLLFFIGLLLILILQVTGGILGAVYKPQLEEGLNLTLKEAADLLKGNSENAKQVQESWQKFQLQGQCCGLDNGINDWGTNSNSVFDGKKVCECEKKYQEENLCYLYQDRYIFKQSCKTLLLDFLKKNMDIIMGIAFGMAVIEVLGLVFSMCLYCQIQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TXS5</accession>
    <name>A0A8C2TXS5_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TXS5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005025370.1">
        <property type="protein sequence ID" value="ENSCJPP00005018216.1"/>
        <property type="gene ID" value="ENSCJPG00005014843.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160650"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051064">
        <property type="entry name" value="SEC14/CRAL-TRIO_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23324">
        <property type="entry name" value="SEC14 RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23324:SF83">
        <property type="entry name" value="SEC14-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="17"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005018216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="258" mass="28854" checksum="048552B0D9122F95" modified="2022-01-19" version="1">VDVRKRMDADNIVAWEAPEVIRKYMAGGMCGYDREGSPVWYDIIGPLDPKGLLFSASKQDLLKNKFRDCELLRLECEKQSQKLGKKVETVLMVYDCEGLGLKHLWKPAVEAYGELLAMFEENYPESLKRLLIVKALLSPVAYNLVKHFLSEDTRTEGHANVKESSISTSSPRRSGGVRGHADDPDGNPKSTNGGTYPRPGCVLRADVASGLYLKTKVGERQRAGDMTEVFPSQRYNAHMVRGRLPHALHARPLDVLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TY58</accession>
    <name>A0A8C2TY58_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="28">Aldehyde dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="35" type="primary">ALDH3A2</name>
    </gene>
    <organism evidence="35 36">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="35" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="35" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="35" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>(2E)-hexadecenal + NAD(+) + H2O = (E)-hexadec-2-enoate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:36135"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17585"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:72745"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(2E,6E)-farnesal + NAD(+) + H2O = (2E,6E)-farnesoate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:24216"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15894"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83276"/>
            <dbReference type="EC" id="1.2.1.94"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2,6,10,14-tetramethylpentadecanal + NAD(+) + H2O = 2,6,10,14-tetramethylpentadecanoate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:44016"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49189"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:77268"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>22-oxodocosanoate + NAD(+) + H2O = docosanedioate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:39015"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:76298"/>
            <dbReference type="ChEBI" id="CHEBI:76299"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>a fatty aldehyde + NAD(+) + H2O = a fatty acid + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:49832"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:35746"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>decanal + NAD(+) + H2O = decanoate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:44104"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:27689"/>
            <dbReference type="ChEBI" id="CHEBI:31457"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>dodecanoate + NADH + 2 H(+) = dodecanal + NAD(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:44168"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18262"/>
            <dbReference type="ChEBI" id="CHEBI:27836"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>heptanal + NAD(+) + H2O = heptanoate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:44108"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32362"/>
            <dbReference type="ChEBI" id="CHEBI:34787"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>hexadecanoate + NADH + 2 H(+) = hexadecanal + NAD(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:33739"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17600"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>octadecanal + NAD(+) + H2O = octadecanoate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:44020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17034"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>octanal + NAD(+) + H2O = octanoate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:44100"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17935"/>
            <dbReference type="ChEBI" id="CHEBI:25646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>tetradecanal + NAD(+) + H2O = tetradecanoate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:44172"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30807"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:84067"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 28 31">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TY58"/>
    <dbReference type="Ensembl" id="ENSCJPT00005028245.1">
        <property type="protein sequence ID" value="ENSCJPP00005020468.1"/>
        <property type="gene ID" value="ENSCJPG00005016453.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157944"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004028">
        <property type="term" value="F:3-chloroallyl aldehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120553">
        <property type="term" value="F:farnesal dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050061">
        <property type="term" value="F:long-chain fatty aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046577">
        <property type="term" value="F:long-chain-alcohol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052814">
        <property type="term" value="F:medium-chain fatty aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007417">
        <property type="term" value="P:central nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008544">
        <property type="term" value="P:epidermis development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046458">
        <property type="term" value="P:hexadecanal metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007422">
        <property type="term" value="P:peripheral nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033306">
        <property type="term" value="P:phytol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd07132">
        <property type="entry name" value="ALDH_F3AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000003">
        <property type="entry name" value="Aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000004">
        <property type="entry name" value="Aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012394">
        <property type="entry name" value="Aldehyde_DH_NAD(P)"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570:SF9">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE FAMILY 3 MEMBER A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036492">
        <property type="entry name" value="ALDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="32" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14 33" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12" id="KW-0520">NAD</keyword>
    <keyword evidence="11 28 31" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="36" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 33" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 33" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="33">
        <location>
            <begin position="482"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="34">
        <location>
            <begin position="22"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="32">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="active site" evidence="29 30">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <feature type="active site" evidence="29">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00048826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00048895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00048972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00049148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="PIRNR" id="PIRNR036492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="PIRSR" id="PIRSR036492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="34">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="35">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005020468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="36">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="527" mass="58496" checksum="A49DC5C9B03D623B" modified="2022-01-19" version="1">MQLCALMPAVPRSRSAVMGRMAEVVGRARAAFRSGRSRPLEFRLQQLRNLQRMVREKEREILAAIGADLHKCGHNAYSHEIMGVLGELALTMEKLPSWAAPRPVKKNLLTLRDEAYINPEPLGVVLVIGAWNYPFVLVMQPLIGAIAAGNAVVVKPSEVSENTSQLIADILPQYLDPELYPVVTGGVPETTELLEQRFDHILYTGNSTVGKIVMAAAAKHLTPVTLELGGKSPCYIDTNCDLAVACRRITWGKYMNCGQTCIAPDYILCHPSIQSKVVENIKATLQEFYGEDVKKCPDYERIINKRHFKRIMSLLEGQKIAHGGETDEASCFIAPTILTDVTAESKVMEEEIFGPVLPIVSVKNVDEAIEFINRREKPLALYVFSNDKKLIKRVISETSSGGVTGNDVIMHFFLSTLPFGGVGNSGMGAYHGKHSFDTFSHHRSCLIKDLKMEGTNAVRYPPSSQKKLDWAKFFILKRFNKGHVGLIMMALLGLVAAVVIKNHHSVLKRKALLVLLAVERRGWLSVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U0W6</accession>
    <name>A0A8C2U0W6_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ras-related GTP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">RRAGC</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lysosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the GTR/RAG GTP-binding protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015739021.1">
        <property type="nucleotide sequence ID" value="XM_015883535.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U0W6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005027974.1">
        <property type="protein sequence ID" value="ENSCJPP00005020287.1"/>
        <property type="gene ID" value="ENSCJPG00005016357.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107323946"/>
    <dbReference type="KEGG" id="cjo:107323946"/>
    <dbReference type="CTD" id="64121"/>
    <dbReference type="GeneTree" id="ENSGT00950000183031"/>
    <dbReference type="OrthoDB" id="26136at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990877">
        <property type="term" value="C:FNIP-folliculin RagC/D GAP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990131">
        <property type="term" value="C:Gtr1-Gtr2 GTPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140767">
        <property type="term" value="F:enzyme-substrate adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019003">
        <property type="term" value="F:GDP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051020">
        <property type="term" value="F:GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071230">
        <property type="term" value="P:cellular response to amino acid stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007040">
        <property type="term" value="P:lysosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900181">
        <property type="term" value="P:negative regulation of protein localization to nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045947">
        <property type="term" value="P:negative regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045948">
        <property type="term" value="P:positive regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031648">
        <property type="term" value="P:protein destabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061462">
        <property type="term" value="P:protein localization to lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd11385">
        <property type="entry name" value="RagC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.190:FF:000001">
        <property type="entry name" value="Ras-related GTP-binding protein C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000226">
        <property type="entry name" value="Ras-related GTP-binding protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006762">
        <property type="entry name" value="Gtr1_RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039400">
        <property type="entry name" value="RagC/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259">
        <property type="entry name" value="RAS-RELATED GTP BINDING RAG/GTR YEAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259:SF6">
        <property type="entry name" value="RAS-RELATED GTP-BINDING PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04670">
        <property type="entry name" value="Gtr1_RagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 12" id="KW-0458">Lysosome</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005020287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="406" mass="44735" checksum="66AEC4CB9599A8C9" modified="2022-01-19" version="1">MALQFGGAGAAEEPALVGGSFGTADSFPKDFGYGEEEEEAELEGGPGPGGTGGGAGGPGGGAGGADSKPRILLMGLRRSGKSSIQKVVFHKMSPNETLFLESTNKIYKDDISNSSFVNFQIWDFPGQMDFFDPTFDYEMIFRGTGALIYVIDAQDDYMEALTRLHITVSKAYKVNPEMNFEVFIHKVDGLSDDHKIETQRDIHQRANDDLTDAGLEKLHLSFYLTSIYDHSIFEAFSKVVQKLIPQLPTLENLLNIFISNSGIEKAFLFDVVSKIYIATDSSPVDMQSYELCCDMIDVVIDVSCIYGLKEDGTGSAYDKESMAIIKLNNTTVLYLKEVTKFLALVCILREESFERKGLIDYNFHCFRKAIHEVFEVGVASHRICNHQASASSLKAVTHNGTPRNAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U162</accession>
    <name>A0A8C2U162_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">KIND domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the spire family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2U162"/>
    <dbReference type="Ensembl" id="ENSCJPT00005029960.1">
        <property type="protein sequence ID" value="ENSCJPP00005021861.1"/>
        <property type="gene ID" value="ENSCJPG00005017459.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00960000189323"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051639">
        <property type="term" value="P:actin filament network formation"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="term" value="P:establishment of meiotic spindle localization"/>
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        <property type="term" value="P:polar body extrusion after meiotic divisions"/>
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        <property type="term" value="P:protein transport"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
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        <property type="entry name" value="KIND_dom"/>
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        <property type="entry name" value="Spire"/>
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        <property type="entry name" value="KIND DOMAIN-CONTAINING PROTEIN"/>
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        <property type="entry name" value="SPIRE"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF16474">
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        <property type="entry name" value="KIND"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="KIND" evidence="14">
        <location>
            <begin position="15"/>
            <end position="96"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
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    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
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    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51377"/>
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    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005021861.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="96" mass="11213" checksum="F482A7E2CCA48464" modified="2022-01-19" version="1">MNTESPCCEQNAAKISLAEILRCFEHPISEEQAWAICFWCCFRMKELAQGRLRKMDEEDLLETHMQKKEKQWVRDLIPSLEEVGLVCLPLLSEVSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U2P4</accession>
    <name>A0A8C2U2P4_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase C and casein kinase substrate in neurons protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">PACSIN1</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cell projection</location>
            <location evidence="4">Ruffle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Synapse</location>
            <location evidence="17">Synaptosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015740758.1">
        <property type="nucleotide sequence ID" value="XM_015885272.2"/>
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    <dbReference type="RefSeq" id="XP_015740759.1">
        <property type="nucleotide sequence ID" value="XM_015885273.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015740760.1">
        <property type="nucleotide sequence ID" value="XM_015885274.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U2P4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005030889.1">
        <property type="protein sequence ID" value="ENSCJPP00005022545.1"/>
        <property type="gene ID" value="ENSCJPG00005017903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107324874"/>
    <dbReference type="KEGG" id="cjo:107324874"/>
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    <dbReference type="GeneTree" id="ENSGT00950000182973"/>
    <dbReference type="OrthoDB" id="10255128at2759"/>
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        <property type="component" value="Chromosome 26"/>
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        <property type="term" value="C:COPI-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005829">
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0098684">
        <property type="term" value="C:photoreceptor ribbon synapse"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0098833">
        <property type="term" value="C:presynaptic endocytic zone"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0032587">
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008092">
        <property type="term" value="F:cytoskeletal protein binding"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0045806">
        <property type="term" value="P:negative regulation of endocytosis"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048812">
        <property type="term" value="P:neuron projection morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900006">
        <property type="term" value="P:positive regulation of dendrite development"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048488">
        <property type="term" value="P:synaptic vesicle endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd07680">
        <property type="entry name" value="F-BAR_PACSIN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11998">
        <property type="entry name" value="SH3_PACSIN1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000014">
        <property type="entry name" value="Kinase C and casein kinase substrate in neurons protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000205">
        <property type="entry name" value="Protein kinase C and casein kinase substrate in neurons protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035743">
        <property type="entry name" value="PACSIN1/PACSIN2_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037454">
        <property type="entry name" value="PACSIN1_F-BAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065:SF16">
        <property type="entry name" value="PROTEIN KINASE C AND CASEIN KINASE SUBSTRATE IN NEURONS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0966">Cell projection</keyword>
    <keyword evidence="12 19 20" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="16" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="9" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="13" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 18" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="11" id="KW-0770">Synapse</keyword>
    <keyword evidence="10" id="KW-0771">Synaptosome</keyword>
    <feature type="domain" description="F-BAR" evidence="23">
        <location>
            <begin position="13"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="22">
        <location>
            <begin position="386"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="315"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="188"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="330"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="365"/>
            <end position="377"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004284"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022599"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00034102"/>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
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    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005022545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="445" mass="50953" checksum="984236C04AEB356D" modified="2022-01-19" version="1">MSGSYDESAAATEETTDSFWEVGNYKRTVKRIDDGHRLCNDLMNCVHERAKIEKSYAQQLTDWSKRWRQLIEKGPQYGSLERAWGAIMTEADKVSELHQEVKNSLLNDDFEKVKNWQKDAYHKQIMGGFKEAKEAEDGFRKAQKPWAKKLKELETAKKAYHLACKEEKLAMTREANSKADQSNTPEQQKKLQDKVEKCKQDVQKTQEKYEKVLDELNKCTPQYMESMEQVFEQCQQFEEKRLNFLKEVLLDIKRHLNLAESSSYANVYRELEQTIRLSDAQEDLRWFRSTSGPGMPMNWPQFEEWNPDLTHTITRKEKVKKGEGVTLTNASSTGESGASAGERGSVSSHDRGQTYSAEWSDDEGSNSFNANEANGGTNPFDEDSAGKGVRVRALYDYDGQEQDELSFKAGDELTKLGEEDEQGWCKGRLDNGQLGLYPANYVEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U529</accession>
    <name>A0A8C2U529_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">H6 family homeobox 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">HMX1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the HMX homeobox family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2U529"/>
    <dbReference type="Ensembl" id="ENSCJPT00005032054.1">
        <property type="protein sequence ID" value="ENSCJPP00005023394.1"/>
        <property type="gene ID" value="ENSCJPG00005018561.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158286"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000053">
        <property type="entry name" value="H6 family homeobox 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051300">
        <property type="entry name" value="HMX_Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46110">
        <property type="entry name" value="HOMEOBOX PROTEIN HMX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46110:SF1">
        <property type="entry name" value="HOMEOBOX PROTEIN HMX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 9 10" id="KW-0371">Homeobox</keyword>
    <keyword evidence="7 9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="12">
        <location>
            <begin position="184"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="9">
        <location>
            <begin position="186"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="124"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="166"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005023394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="318" mass="33794" checksum="1118C1928D25C279" modified="2022-01-19" version="1">GGYKTCWQSNSGFQRGRIGASLTQRQEAAAGQRGAEEPSSAVLPTMPDEATENAGSTSARVSSFFIEDLLGTEGGGGARRAAVGGGGGRGAPRCGPHSPLRLGASGCPLRDAAVGWYRRAFLGCTSPDTSDRDSPELPEDTERAGGGERAAARGPVGGRQSSGGREEEEERGEEAGEAEQRAAGRKKKTRTVFSRSQVFQLESTFDMKRYLSSSERACLAASLHLTETQVKIWFQNRRNKWKRQLAAELEAANLSHAAQRIVRVPILYHENSPASALGFGLPHMSPPLVGFSGGVSYPLGTFPAASLPFLRSQMTGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U664</accession>
    <name>A0A8C2U664_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FERM and PDZ domain-containing protein 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">PDZ domain-containing protein 10</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">PSD-95-interacting regulator of spine morphogenesis</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">FRMPD4</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Positive regulator of dendritic spine morphogenesis and density. Required for the maintenance of excitatory synaptic transmission. Binds phosphatidylinositol 4,5-bisphosphate.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts (via C-terminus) with DLG1, DLG2, DLG3 and DLG4/PSD95. Interacts (via N-terminus) with ARHGEF7; the interaction is mediated by the PDZ domain. Interacts with GPSM2 (via TPR repeat region).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Dendritic spine</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015742649.1">
        <property type="nucleotide sequence ID" value="XM_015887163.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005031405.1">
        <property type="protein sequence ID" value="ENSCJPP00005022919.1"/>
        <property type="gene ID" value="ENSCJPG00005018208.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107325883"/>
    <dbReference type="CTD" id="9758"/>
    <dbReference type="GeneTree" id="ENSGT00950000183035"/>
    <dbReference type="OrthoDB" id="5859304at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043197">
        <property type="term" value="C:dendritic spine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13183">
        <property type="entry name" value="FERM_C_FRMPD1_FRMPD3_FRMPD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17170">
        <property type="entry name" value="FERM_F1_FRMPD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21943">
        <property type="entry name" value="LGNbd_FRMPD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06769">
        <property type="entry name" value="PDZ_FRMPD1_3_4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000009">
        <property type="entry name" value="FERM and PDZ domain containing 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000057">
        <property type="entry name" value="FERM and PDZ domain-containing protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000066">
        <property type="entry name" value="FERM and PDZ domain-containing protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000053">
        <property type="entry name" value="FERM and PDZ domain-containing protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049385">
        <property type="entry name" value="FAK1-like_FERM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041779">
        <property type="entry name" value="FRMPD1/3/4_FERM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46221:SF4">
        <property type="entry name" value="FERM AND PDZ DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46221">
        <property type="entry name" value="FERM AND PDZ DOMAIN-CONTAINING PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21477">
        <property type="entry name" value="FERM_C_FAK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0770">Synapse</keyword>
    <feature type="domain" description="WW" evidence="11">
        <location>
            <begin position="33"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="13">
        <location>
            <begin position="78"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="FERM" evidence="12">
        <location>
            <begin position="204"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="806"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="897"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1027"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1089"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="899"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1037"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1115"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1166"/>
            <end position="1175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00056589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00062551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00070890"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00076419"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00076507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
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    <evidence type="ECO:0000259" key="12">
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        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
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    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005022919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1313" mass="144799" checksum="36FFB0930D75283F" modified="2022-01-19" version="1">MDVFSFVKLGKLSGHRNKSSGWPHPSGTWSLNQGTPYGWEMTANRDGRDYFINHMTQSATFEDPRIESCQITPPAPRKVEMRRDPVLGFGFVAGSEKPVVVRSVTPGGPSEGKLIPGDQIIMINDEPVSTAPRERVIDLVRSCKESILLTVVQPYPSPKSAFISAAKKARLKSNPVKVRFSEEVIINGQVSETVKDNSLLFMPNVLKVYLENGQTKSFRFDCSTSIKDVILTLQEKLSIKCIEHFSLMLEQRVEGSGTKLLLLHEQETLTQVTQRPSSHKMRCLFRISFVPKDPIDLLRRDPVAFEYLYVQSCNDVVQERFGPELKYDIALRLAALQMYIATVTTKQTQKISLKYIEKEWGLETFLPSAVLQSMKEKNIKKALSHLVKANQNLVPPGKKLSALQAKVHYLKFLSDLRLYGGRVFKATLVQGEKRSEVTLLVGPRYGISHVINTKTNLVALLADFSHVNRIEMFTEDESSVRVELHVLDVKPITLLMESSDAMNLACLTAGYYRLLVDSRRSIFNMANKKNAGNRETGIENRGKHNLLASEWNCVPKTTTFLAEDQETQMSFGDPKQKAIDVSESLLCQKEHRHLYIENTYNSGGFDQHLTKQDPTDTEESRNFNQPSLLSLSGLESSKKAQDSPRGAKVSFIFGDHNLDGINPQTLGYERLLDESPEVLEKQRAIYINNANDIKGLELSPDAESIQFATNAVYATISDGKIFGAAEGIEEPLLHDICYAENTDDAEDEDEVSCEEDIMVGEINRPALLSLSGSNDDIIDLTSLPPPEGDDNEDDFLLHTLNMAIAAPPPGFRDSSDEEDSQNQATQPRDDKEQASNLGSDDIPVSLIDAVPTNTEGKCEKGLDDAVVSTLQALEALAASEEQQTSDNSGVAILRAYSPESSSDSGNETNSSEMTESSELAAAQKHSENTARMFLTTSEGYQPLVEEQTEFPIAKSQAGGPGMKSSQPLVGRQAADLQSKVVPSKQILHSDNMEMEPETMETKSVTDYFSKLHMGSLVYSCTSKRKSKMTESEVKASSDGNATVKKQQGTKKAETDEELKAKFGTISARDSQRLSTFNVERTAFRQRWYGADDGAADKPSPEAANGKTFPRVPVRGKAETDCKDEVDPEVDQDDTSGLSQGENFLSDMTPVSSAKDLNDAEDTDLSADDHPSKLPEAEQSVARLCEYHLAKRMSSLQSEGHFSLQSSQCSSVDAGCSTGSSTCATPVESPLCSSDVKHVISDPSMKGIAYIPADERAAILPNHGTTYKDLHQQPEAVCHRMTVPVVHSAINAEPLFGTLREGCHRIPKIKETTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U6B3</accession>
    <name>A0A8C2U6B3_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">mRNA decay activator protein ZFP36</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Zinc finger protein 36</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ZFP36L1</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes. Binds to 3'-UTR ARE of numerous mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Associates with the cytoplasmic CCR4-NOT deadenylase complex to trigger ARE-containing mRNA deadenylation and decay processes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015720368.1">
        <property type="nucleotide sequence ID" value="XM_015864882.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U6B3"/>
    <dbReference type="SMR" id="A0A8C2U6B3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005030070.1">
        <property type="protein sequence ID" value="ENSCJPP00005021954.1"/>
        <property type="gene ID" value="ENSCJPG00005017519.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107314974"/>
    <dbReference type="KEGG" id="cjo:107314974"/>
    <dbReference type="CTD" id="677"/>
    <dbReference type="GeneTree" id="ENSGT00940000155076"/>
    <dbReference type="OrthoDB" id="410307at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071889">
        <property type="term" value="F:14-3-3 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061158">
        <property type="term" value="P:3'-UTR-mediated mRNA destabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071320">
        <property type="term" value="P:cellular response to cAMP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071364">
        <property type="term" value="P:cellular response to epidermal growth factor stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071385">
        <property type="term" value="P:cellular response to glucocorticoid stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071456">
        <property type="term" value="P:cellular response to hypoxia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032869">
        <property type="term" value="P:cellular response to insulin stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071560">
        <property type="term" value="P:cellular response to transforming growth factor beta stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071356">
        <property type="term" value="P:cellular response to tumor necrosis factor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070371">
        <property type="term" value="P:ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045647">
        <property type="term" value="P:negative regulation of erythrocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043491">
        <property type="term" value="P:phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904582">
        <property type="term" value="P:positive regulation of intracellular mRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045657">
        <property type="term" value="P:positive regulation of monocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900153">
        <property type="term" value="P:positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902172">
        <property type="term" value="P:regulation of keratinocyte apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045616">
        <property type="term" value="P:regulation of keratinocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010837">
        <property type="term" value="P:regulation of keratinocyte proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031440">
        <property type="term" value="P:regulation of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009611">
        <property type="term" value="P:response to wounding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000001">
        <property type="entry name" value="zinc finger CCCH domain-containing protein 15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000002">
        <property type="entry name" value="Zinc finger protein 36, C3H1 type-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007635">
        <property type="entry name" value="Tis11B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045877">
        <property type="entry name" value="ZFP36-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547">
        <property type="entry name" value="CCCH ZINC FINGER/TIS11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547:SF53">
        <property type="entry name" value="MRNA DECAY ACTIVATOR PROTEIN ZFP36L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04553">
        <property type="entry name" value="Tis11B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="13">
        <location>
            <begin position="112"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="13">
        <location>
            <begin position="150"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="10">
        <location>
            <begin position="112"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="10">
        <location>
            <begin position="150"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="274"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU369014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005021954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="335" mass="36020" checksum="12FD7D4BA00C899C" modified="2022-01-19" version="1">MSTALVSPTIFDLSEVLCKSSKMLNYSPAGVGGCLLDRKAVGTPAGGGFPRRHSVTLPNAKFHQSQLLGGLKGEPAPALGPRESRFRDRSFSEGGERLLQQKQPGGQVNSSRYKTELCRPFEENGACKYGDKCQFAHGIHELRSLTRHPKYKTELCRTFHTIGFCPYGPRCHFIHNAEERRAVAGGREPPAADRPRLQHSFSFAGFPSAAAPGLLDSPTSVTPPPMLSADDLLGSPTLPDCASNPFTFSSQELVSLFAPSVGVPVPGGSSPTAFLFRPMSESPHMFDSPPSPQDSLSDQEGYLSSSSSSHSGSDSPILDTSRRLPIFSRLSISDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U7M1</accession>
    <name>A0A8C2U7M1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Anaphase-promoting complex subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14 15">Cyclosome subunit 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">ANAPC4</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 15">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13 15">Belongs to the APC4 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015718140.1">
        <property type="nucleotide sequence ID" value="XM_015862654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U7M1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005031693.1">
        <property type="protein sequence ID" value="ENSCJPP00005023117.1"/>
        <property type="gene ID" value="ENSCJPG00005018368.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107313933"/>
    <dbReference type="KEGG" id="cjo:107313933"/>
    <dbReference type="CTD" id="29945"/>
    <dbReference type="GeneTree" id="ENSGT00390000004612"/>
    <dbReference type="OrthoDB" id="2110451at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019903">
        <property type="term" value="F:protein phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141198">
        <property type="term" value="P:protein branched polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070936">
        <property type="term" value="P:protein K48-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030071">
        <property type="term" value="P:regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001243">
        <property type="entry name" value="Anaphase-promoting complex subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024789">
        <property type="entry name" value="APC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056358">
        <property type="entry name" value="APC4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024790">
        <property type="entry name" value="APC4_long_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017169">
        <property type="entry name" value="APC4_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13260">
        <property type="entry name" value="ANAPHASE PROMOTING COMPLEX SUBUNIT 4 APC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13260:SF0">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12896">
        <property type="entry name" value="ANAPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23405">
        <property type="entry name" value="WD40_APC4_C-half"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037303">
        <property type="entry name" value="APC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6 15" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="7 15" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="8 15" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="17">
        <location>
            <begin position="19"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 4 long" evidence="18">
        <location>
            <begin position="228"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 4 C-terminal half WD40" evidence="19">
        <location>
            <begin position="570"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="744"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="744"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="785"/>
            <end position="797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00061648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00082690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR037303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF12896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF23405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005023117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="797" mass="90453" checksum="C12506D468C3482A" modified="2022-01-19" version="1">MPAFRQVGEKQLPQEVVVMAWSPKRDLIALANRAGEVLLHRLANFQRVWSLPPNENTGKEVTALAWRPDGKILAFGLADTKRIILCDVEKPESLHSFSVNLSVTYMHWMEVTAESSILTSFYNAEDEANLVLPKLPALPKNYSTTAKIFSEEKSDEIMKLLGDVRLNALVLGGSSGFIEIYAYGMFKIATVTEVAGSCRGLCLSSDLKSLSVIAEIQDSPDSEAEITYFQLDTSLLSNYLPEVTRMARKFTHISTLLQYIKLSLTCMCEAWEEILMQMDSRLTKFVQEKNTTTSVQDEFMQLLLWGKASLELQALLMNQLTVKGLKKLGQSIESSYSSIQKLVISHLQSGSEALLYYLSELKGMALWKQKYESLGLDASGIEEATTAVGSFILKANELLQVIDSSMKNFKAFFRWLYVAMLRMSEDHVLPELNKMTQKDITFVADFLTEHFNEAPELYNRKGKYFNVERVGQYLKDEDEDLVSPPNTEGNQWFHFLKNSTHLKESPLLFPYYPEKSLHFVKRQMEEVIDQCLQKPADVIGKSVRQAFCASLYKTSRSEDSSPQLFKLPFLWNDKTSNLHYVLFTILEGSISKIHILRRHTDTSRSVGNGIVAVEFGNFLNNSINESSDSRCYSCLDAHFYDDETVTVVLKESVEQEGKERILAQLPLSSVYTDEDQEVEFIWDSTKRLDEQSDEIATRTVFLDSQWRVLENMKAQYVAVNGIRKVSCVLSSNLRHVRVFEMDVEDDGEVEEEEEEETTQIAAGEPEEPNRSVDNQENVCGASAEELPDEAEENESNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UAT5</accession>
    <name>A0A8C2UAT5_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Semaphorin-6D</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">SEMA6D</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Shows growth cone collapsing activity on dorsal root ganglion (DRG) neurons in vitro. May be a stop signal for the DRG neurons in their target areas, and possibly also for other neurons. May also be involved in the maintenance and remodeling of neuronal connections. Ligand of TREM2 with PLXNA1 as coreceptor in dendritic cells, plays a role in the generation of immune responses and skeletal homeostasis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2UAT5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005034021.1">
        <property type="protein sequence ID" value="ENSCJPP00005024985.1"/>
        <property type="gene ID" value="ENSCJPG00005019571.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159303"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045499">
        <property type="term" value="F:chemorepellent activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030215">
        <property type="term" value="F:semaphorin receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014912">
        <property type="term" value="P:negative regulation of smooth muscle cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001755">
        <property type="term" value="P:neural crest cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014911">
        <property type="term" value="P:positive regulation of smooth muscle cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071526">
        <property type="term" value="P:semaphorin-plexin signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014909">
        <property type="term" value="P:smooth muscle cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002291">
        <property type="term" value="P:T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021591">
        <property type="term" value="P:ventricular system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1680.10:FF:000004">
        <property type="entry name" value="semaphorin-6D isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000013">
        <property type="entry name" value="semaphorin-6D isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1680.10">
        <property type="entry name" value="ligand-binding face of the semaphorins, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002165">
        <property type="entry name" value="Plexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001627">
        <property type="entry name" value="Semap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036352">
        <property type="entry name" value="Semap_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027231">
        <property type="entry name" value="Semaphorin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036">
        <property type="entry name" value="SEMAPHORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036:SF65">
        <property type="entry name" value="SEMAPHORIN-6D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01437">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01403">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00630">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103575">
        <property type="entry name" value="Plexin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101912">
        <property type="entry name" value="Sema domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51004">
        <property type="entry name" value="SEMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-0221">Differentiation</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 18" id="KW-0732">Signal</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034467544" description="Semaphorin-6D" evidence="18">
        <location>
            <begin position="21"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="668"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="domain" description="Sema" evidence="19">
        <location>
            <begin position="27"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="750"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="852"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="927"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1032"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="779"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="796"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="857"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="941"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="990"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1032"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1069"/>
            <end position="1083"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022902"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022989"/>
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            <dbReference type="ARBA" id="ARBA00023136"/>
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            <dbReference type="ARBA" id="ARBA00023157"/>
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            <dbReference type="ARBA" id="ARBA00060308"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00074110"/>
        </source>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00352"/>
        </source>
    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS51004"/>
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    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005024985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
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    </evidence>
    <sequence length="1083" mass="120836" checksum="0CF9F6B257FC2516" modified="2022-01-19" version="1">MRLTLLCASVMLMSLSQCRAVSFPEDEDPINVVDYHYSRQYPVFRGRPSGNESQHRLDFQLMLKIRDTLYIAGRDQVYTVNLNEVPKSEVTPSRKLTWRSRQKVSLCPRIDECHNFIKVFVPRNDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEISGLARCPFDARQTNVALFADGKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFLHAIEYGNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSFFYFDVLQSITDIIEINGIPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPEDKVPKPRPGCCAKHGLAEAYKTSIDFPDETLSFIKSHPLMDSAVPSIIEEPWFTKTRVRYRLTAIAVDHAAGPHQNYTVIFVGSEAGVVLKILAKTRPFSLNDSVLLEEIEAYNHAKCNAESEEDRRVISLQLDRDHHALFVAFSSCVIRIPLSRCERHGSCKKACIASRDPYCGWLDHEACGRVTPGMPFSLFVSYNHSTGGYVQDVEYGNTAQLGDCHEILPTTATPDYKIFGDPTSDMKFSSASITTMASIPVISPRVIGSWKPKVTGSRKFVVQDDPNTSDYSDPLSGVPKGVRWEVQSGESNQMVHMNVLITCVFAAFVLGAFIAGVAVYCYRDVFVRKSRKIHKDAESAQSCTDSSGSFAKLNGLFDSPVKEYQQNIDSPKLYTNLLTSRKELPPNGDMKSMMMDHRGQPPELAALPTPESTPVLQQKTLQAMKSQSDKAHGNLNASRKETPLKSPQFFPSSPPPHSPLSHGHIPSAIVLPNATHDYNTSFSNSNAHKADKKMQHIDHPLTKPSSKRDHRRSVDSRNTLNDFLKHLNETTSNPKAIMGDIQVAHQTLMLDPMGNMSEIPPKVPNREASLYSPPSTLPRNSPTKRVDVPTTPAVPMTSLERQRGYHKNSSQRHSISALPKNLNSPNGVLLSRQPSINRGGYVTPTAGTKMDYMQGTPVSVHLQPSLSRQSSYTSNGTLPRTGIKRTPSLKPDVPPKPSFVPQTTSVRPLNKYSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UBJ4</accession>
    <name>A0A8C2UBJ4_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Small ribosomal subunit protein uS17 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UBJ4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005034424.1">
        <property type="protein sequence ID" value="ENSCJPP00005025293.1"/>
        <property type="gene ID" value="ENSCJPG00005019871.1"/>
    </dbReference>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032440">
        <property type="entry name" value="Ribosomal_uS17_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16205">
        <property type="entry name" value="Ribosomal_S17_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS17 N-terminal" evidence="2">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005025293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="81" mass="8936" checksum="4A000EEABF6D8B59" modified="2022-01-19" version="1">VLEQKVYIGILEEASASGKIYFKILHLHSIYIDKKCPLTGNVSIRGQILSDVVTKMNAKCILFRGLPLQGQHSVLIPSKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UD05</accession>
    <name>A0A8C2UD05_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Zinc finger protein 652</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ZNF652</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015741064.1">
        <property type="nucleotide sequence ID" value="XM_015885578.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UD05"/>
    <dbReference type="Ensembl" id="ENSCJPT00005033461.1">
        <property type="protein sequence ID" value="ENSCJPP00005024569.1"/>
        <property type="gene ID" value="ENSCJPG00005019351.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107325082"/>
    <dbReference type="KEGG" id="cjo:107325082"/>
    <dbReference type="CTD" id="22834"/>
    <dbReference type="GeneTree" id="ENSGT00940000157416"/>
    <dbReference type="OrthoDB" id="427030at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000900">
        <property type="entry name" value="Zinc finger and BTB domain containing 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000312">
        <property type="entry name" value="Zinc finger and BTB domain-containing 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000550">
        <property type="entry name" value="Zinc finger and BTB domain-containing 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000166">
        <property type="entry name" value="Zinc finger and BTB domain-containing 49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001300">
        <property type="entry name" value="Zinc finger and BTB domain-containing protein 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001378">
        <property type="entry name" value="Zinc finger protein 652"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000284">
        <property type="entry name" value="Zinc finger protein 652 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393:SF15">
        <property type="entry name" value="IP01243P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="248"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="275"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="302"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="332"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="360"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="388"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="416"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="444"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="472"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="61"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="544"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="71"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="98"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="175"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="198"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="230"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="551"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="565"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005024569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="609" mass="69966" checksum="35FEEB545D2C2340" modified="2022-01-19" version="1">MSQTANSCQQLVENCAVHVAGMAQEDSRRGQVPPTFYHGASQELDLSTKVYKRESGSPYPVLVDSKMSKPHLHEREEQPYFRENRSVGEVRAVKEDRENSDDSEEEEEEEDEVTYKREQIIVEVNLNNQTLNVSKGEKGVPSQSKETAVLKTSSEEEEGDSGEEATEDSNDYEENERQKKKEKRVEKVSVAQRRTRRAASAAAATTSPSPRTTRGRRKSVEPPKRKKKAAKEPKAPVQKSKCEEKETLTCEKCPRVFNTRWYLEKHMNVTHRRMQICDKCGKKFVLESELSLHQQTDCEKNIQCVSCNKSFKKLWSLHEHIKIVHGYAEKKFSCEICEKKFYTMAHVRKHMVAHTKDMPFTCETCGKSFKRSMSLKVHSLQHSGEKPFKCENCDERFQYKYQLRSHMSIHIGHKQFMCQWCGKDFNMKQYFDEHMKTHTGEKPFICEICGKSFTSRPNMKRHRRTHTGEKPYPCDVCGQRFRFSNMLKAHKEKCFRVTSPVNVSSAVQIPLSTTSATTVPAVVNTPTAPTPPINLNPVSTLPPRPIPHPYSHLHLHPHPHHPHHLPVPPVPHLPPPPALFKSEPLNHRGQSEDSFLRHLAEKNSSAQHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UEB9</accession>
    <name>A0A8C2UEB9_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Eukaryotic translation initiation factor 3 subunit J</fullName>
            <shortName evidence="6">eIF3j</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Eukaryotic translation initiation factor 3 subunit 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">eIF-3-alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">eIF3 p35</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">EIF3J</name>
        <name evidence="6" type="synonym">EIF3S1</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the eIF-3 subunit J family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2UEB9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005036835.1">
        <property type="protein sequence ID" value="ENSCJPP00005027212.1"/>
        <property type="gene ID" value="ENSCJPG00005021111.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000018400"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.60:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.60">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03009">
        <property type="entry name" value="eIF3j"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023194">
        <property type="entry name" value="eIF3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013906">
        <property type="entry name" value="eIF3j"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21681">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21681:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08597">
        <property type="entry name" value="eIF3_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="42"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="178"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="207"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00065260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005027212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="401" mass="44312" checksum="2D61F555F2DE8ECD" modified="2022-01-19" version="1">MVCSSEPCQLHCAAQGLPGPTPALPAASAAFLPRVPEVIPVLPSTEPPTRAQRAGTAPARPVQPRHGPSSPGTARCTARRPARPRPAGGSGLSALPRWRRCRHLTPPKMAARPHLIPPKMAAAGAGRAPMVPRAPCAELRLSQLAPRSRGKMAAEADSWDADTFEVVEPVAKRLVPGVAGDRWAGEDEDDDVKDNWDDEEEEEEVKETEVKQEPKVSEKKKIAEKIKEKEKQQKKKQEELKKRLEAPEEHKELTPEEQLADKLRLKKLQEESDLELAKETFGVNNTCGIDAMNPSSKDDFTEFGKLLKEKITQYEKSLHYASFLEALVRDVCISLEIDDLKKITNSLTVLCSEKQKQEKSKAKKKKKGVVPGGGLKATMKDDLADYGGYDGEYVQEFEDFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UEC4</accession>
    <name>A0A8C2UEC4_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Carboxypeptidase</fullName>
            <ecNumber evidence="10">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">SCPEP1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">May be involved in vascular wall and kidney homeostasis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="10"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2UEC4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005037317.1">
        <property type="protein sequence ID" value="ENSCJPP00005027637.1"/>
        <property type="gene ID" value="ENSCJPG00005021399.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156193"/>
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        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097746">
        <property type="term" value="P:blood vessel diameter maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045776">
        <property type="term" value="P:negative regulation of blood pressure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF3">
        <property type="entry name" value="RETINOID-INDUCIBLE SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 10" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005027637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="469" mass="53140" checksum="91DE9990776144AB" modified="2022-01-19" version="1">MGRTILSNLNIRKSTPRNSCFRELRREAETRCSEPGSVGLLVFPPLTVFLPTGAALEPPRELWGYVQVRSKAHLFWWLYYSAGYNELPLVLWLQGGPGSSGCGFGNFEEIGPLDKELKPRNTTWLQAASILFVDNPVGTGFSYVDDCSLFAQNLTMVVSDMMVFLKEFFTHRTEFQSIPFYIFSESYGGKMAAGIALELHNAVQQGSIKCSFAGVALGDSWISPLDSVLSWGPYLYSTSLLDDHGLAEVTAVAKEIMDAINNNEYGLATELWSKAEGIIEENTDNVNFYNIMTKEVPEMKMNEQENFHLVRLYQRHVKIMHKNNLNELMNGPIREKLKIIPDCVKWGGQSTKVFENMAEDFMRPVIDIVDQLLAANVNVTVYNGQLDLIVDTMGQEAWIRKLKWPGLKEFSQQRWKALYVSPESTDTAAFHKAYENFAFFWILKAGHMVPSDQGEMALKMVRMVTQQKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UER2</accession>
    <name>A0A8C2UER2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LRRK1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005036029.1">
        <property type="protein sequence ID" value="ENSCJPP00005026579.1"/>
        <property type="gene ID" value="ENSCJPG00005020655.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160363"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045453">
        <property type="term" value="P:bone resorption"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036035">
        <property type="term" value="P:osteoclast development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090263">
        <property type="term" value="P:positive regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902533">
        <property type="term" value="P:positive regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd14067">
        <property type="entry name" value="STKc_LRRK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000753">
        <property type="entry name" value="Leucine rich repeat kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000361">
        <property type="entry name" value="Leucine-rich repeat serine/threonine-protein kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1390:FF:000002">
        <property type="entry name" value="Leucine-rich repeat serine/threonine-protein kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000698">
        <property type="entry name" value="Leucine-rich repeat serine/threonine-protein kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000091">
        <property type="entry name" value="leucine-rich repeat serine/threonine-protein kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1390">
        <property type="entry name" value="ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032171">
        <property type="entry name" value="COR-A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057263">
        <property type="entry name" value="COR-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050647">
        <property type="entry name" value="Plant_LRR-RLKs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020859">
        <property type="entry name" value="ROC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48056">
        <property type="entry name" value="LRR RECEPTOR-LIKE SERINE/THREONINE-PROTEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48056:SF81">
        <property type="entry name" value="RECEPTOR PROTEIN-TYROSINE KINASE CEPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16095">
        <property type="entry name" value="COR-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25497">
        <property type="entry name" value="COR-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08477">
        <property type="entry name" value="Roc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51424">
        <property type="entry name" value="ROC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Roc" evidence="15">
        <location>
            <begin position="624"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="1233"/>
            <end position="1516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1835"/>
            <end position="1879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1846"/>
            <end position="1863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1867"/>
            <end position="1879"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005026579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="2000" mass="223559" checksum="7322D47D1F48BEE9" modified="2022-01-19" version="1">MKQSLGKTEAILVLGLAQRVPSSLRTVGMGGKQSTVGEVSINQTPVTESIQAAYKAGDAAKAQELIKLSCEEAALQVEKCQLLGIAAAYGDLQAVRYLLKEALVVLPTEPNDDNAAVVATYFGHRDVVKELLDSLRGPNTCQQLLNWMLAIACQQGHLDIVKLLIRAYSADPESCAVRRNEFPVLIRLPLYAAIKAGNEDVAVFLLRNGAFFCSYILMDSPESSKHLLRKYFIETSPLPGSAPAKTALCVNWSNLKLPWVDLDWLIDISCQITELDLSANCLVSLPSVIPWGLMNLRKLSLADNQLAELPSVQSSDEIICTRLLEVDVSSNKLSTLPSGFLHLKNLKKLNAAKNYMEKLFDEENTTNWIGLRKLQEFDVSDNRLVEVPTAFLYCFKSLNILNVSRNQLKVFPDPWACPLKCCKASRNSLESLPDTFTVFWKNHLREVDFSENSLKEVPPGLFQLEALVSLKLLGNHLTVLPSQDKWNCKQLKSLDLSKNQLGKNDEGYRTKRIPFFTTRSRVRGGPEAGPFVEFPAFLSDSLEVLYLNDNQLESVPQSVCLLKGLTELYLGNNPGIRELPPELGQLANLWQLDIEELSISNVPAEIRKEGPKTVLAYLRAQLRKAEKCKLMKMIVIGPPRQGKSTLVEILQTGKVPQMMHSDATIRTTKWELPKPVGHKAKVDSVEFNVWDIGGPASMSTVNQCFFTDKALYIVVWNLALGEEAVANLQFWLLNIEAKAPNSAVLVVGTHLDLIETKFRVERIATLRAYVLALCRSPSGSRATGFPDITFKHLHELSCKTLEGLDGLRQLIFHVTCNMKDVGSSICSQKLAGRLIPRSYLSLQEAVLAEQHKRNQNDDVQYLTDRQIELIIEQTPGNDIKDYEDLQTAINFLIETGTLLHFPDTSHGLRNLYFLDPVWLSECLQRIFNIKSSKSVAKNGVIRAEDLRMLLVGTGFTEQTEEQYFQFLAKFEIALPVANNSYLLPHLLPTKPALDIHGFCHQTTNTIQRVFKMSFVPVGFWQRFIARMLISLAEMDLQLFENKKNTKTRNKKVTIYSFTGTQRNRCSTFRVKRTHTVYWQEGLFVTFDGGYLSVESSDVNWKKKKSGGIKIICQSEARDFSAMAFITDHVNSLIDQWFPALTATESDGTLLMEQYVPCHICAASRLEDECGEKAEDAQYFNMEDCVLTAIELDYITCPNHPDIPVSLQELVPELFMTDFPARLFLENSKLECSENENNVLGQGGSGTVIYRARYQGKPVAVKRFQIKKCSGSPTSAADTMLKHLRAMDAMKNFSEFRQEASMLHSLQHPCIVSLIGISIHPLCFALELAPLGSLTTVLSENSKGSSFVPLGHMLTHKIAYQIVTGLAYLHKKNIIFCDLKSDNILVWSLDVKEHVNIKLSDYGISRQSFHEGALGVEGTPGYQAPEIRPRIVYDEKVDMFSYGMVLYELLSGQRPVLGQHQLQIAKKLSKGIRPVLGQPEEVQLYRMQALMMECWDTKPEKRPLAMSVVGQMKDPTFATFMYLLPCGKQSSFFCSQGQEYTVVFWDGKEDTRNYTVVNPEKGVIEVERMSCPGMKLCCQLKFQNTLWAATEDQKISVYRLQGMCPLKAPQKGLDSPAAVSCFLVIPVIKKNSYMVLAGLSDGLVAVFSVAQGIPADSCSYLCSHTANRSKFNIPDDDPRQNPYPVRAMEITNSGTEVWYSNGPGILVIDCTTMEISRRLEPFSPPSAISSIACNSECHGEEVVWCLDEKSNFLVMYHAATYQLCARYFCGDCSPLRDMFAIQQPATAIPATAPINPRTLEGNSLMDMSIIYSPEVGTQILNHQDSLTDYCSVSSYSSSPPNRLTRCPSSLPSSPTSSSSAPLSTDFEESGKFHELKPSPDHDAVPMGDNSQHLQAVKILPVKDLIWIPRRGGDIIVIGLEKESGMQRGRVIAVLKAGELAPYGTLVDAALVAKDTVVCCFQNENTEWCLAVWRGWSARDFDVFYQAYEELGRLETCMRKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UF12</accession>
    <name>A0A8C2UF12_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Voltage-dependent calcium channel gamma-4 subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">CACNG4</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2UF12"/>
    <dbReference type="Ensembl" id="ENSCJPT00005037147.1">
        <property type="protein sequence ID" value="ENSCJPP00005027488.1"/>
        <property type="gene ID" value="ENSCJPG00005021309.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01050000244893"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032281">
        <property type="term" value="C:AMPA glutamate receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990454">
        <property type="term" value="C:L-type voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098839">
        <property type="term" value="C:postsynaptic density membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036477">
        <property type="term" value="C:somatodendritic compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005246">
        <property type="term" value="F:calcium channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005245">
        <property type="term" value="F:voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099590">
        <property type="term" value="P:neurotransmitter receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098943">
        <property type="term" value="P:neurotransmitter receptor transport, postsynaptic endosome to lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051968">
        <property type="term" value="P:positive regulation of synaptic transmission, glutamatergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098970">
        <property type="term" value="P:postsynaptic neurotransmitter receptor diffusion trapping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019226">
        <property type="term" value="P:transmission of nerve impulse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.150:FF:000036">
        <property type="entry name" value="Voltage-dependent calcium channel gamma-4 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051072">
        <property type="entry name" value="CACNG_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004031">
        <property type="entry name" value="PMP22/EMP/MP20/Claudin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005423">
        <property type="entry name" value="VDCC_g4su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008368">
        <property type="entry name" value="VDCC_gsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12107">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12107:SF7">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-4 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00822">
        <property type="entry name" value="PMP22_Claudin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01792">
        <property type="entry name" value="VDCCGAMMA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01603">
        <property type="entry name" value="VDCCGAMMA4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="6" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="6" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="212"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="212"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="232"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005027488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="313" mass="34708" checksum="C1D2363E6B66E0F4" modified="2022-01-19" version="1">MVWCDRGVQMLLTTVGAFAAFSLMAIAIGTDYWLYSSAHICNGTNITADEAQGPPKKARGDLTHSGLWRICCLEAKCGVWKLCCLHSSIVRASSVFPILSTILLLLGGLCVGAGRIYNSKNNIILSAGILFVAAGLSNIIGIIVYISSNAGDPSDKRDEDKKNHYNYGWSFYFGALSFIVAETIGVLAVNIYIEKNKELRFKTKREFLKTSSSSPYARMPSYRYRRRRSRSSSRSTEPSPSRDISPVGMKIASTIPMNEISMYTLSREPLKVTTAASYNADQEASFLQVHNFLQKEFKEGLHVNMVNRRTTPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UF80</accession>
    <name>A0A8C2UF80_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">E3 ubiquitin-protein ligase RNF34</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">RING finger protein 34</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">RING-type E3 ubiquitin transferase RNF34</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="primary">RNF34</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2UF80"/>
    <dbReference type="Ensembl" id="ENSCJPT00005035701.1">
        <property type="protein sequence ID" value="ENSCJPP00005026361.1"/>
        <property type="gene ID" value="ENSCJPG00005020509.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000012719"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002039">
        <property type="term" value="F:p53 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901981">
        <property type="term" value="F:phosphatidylinositol phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <sequence length="344" mass="37968" checksum="68962BF06365E76B" modified="2022-01-19" version="1">MWASCCGLLNEVMGTGAVRGQQSGFAAGAGPFRFAPNAAFSSCPSPAAAAANVVCKACGLPFSVFRKKHVCCDCKKDFCSVCSVLQENLRRCSTCHLLQETAFQRPQLMRLKVKDLRQYLVLRNIPTDTCREKEDLVDLVLCHHGLGPEEDMDAGSLRSSRSQTSGFFTHPFSMSMSVSSQGELANRSTGNGTPLRGQTETSSINNDEEESAEEQTPGLSRKRARASLSDISSLEDIEGLSVRQLKEILACNFVNYSGCCEKWELVEKVSRLYKESEENHKTQGEKVQLNDNDDNLCRICMDAVIDCVLLECGHMVTCTKCGKRMSECPICRQYVVRAVHVFKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y4X8</accession>
    <name>A0A8C2Y4X8_COTJA</name>
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        <submittedName>
            <fullName evidence="11">Shroom family member 3</fullName>
        </submittedName>
    </protein>
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        <name evidence="11" type="primary">SHROOM3</name>
    </gene>
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        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
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        <text evidence="2">Belongs to the shroom family.</text>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        <property type="term" value="P:actin filament organization"/>
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        <property type="entry name" value="Shroom_fam"/>
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    <dbReference type="PANTHER" id="PTHR15012">
        <property type="entry name" value="APICAL PROTEIN/SHROOM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN SHROOM3"/>
        <property type="match status" value="1"/>
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    </dbReference>
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    <keyword evidence="5 7" id="KW-0009">Actin-binding</keyword>
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    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="695"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="713"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="922"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1025"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1128"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1242"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1287"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1325"/>
            <end position="1335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1399"/>
            <end position="1413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1456"/>
            <end position="1465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1498"/>
            <end position="1508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1525"/>
            <end position="1548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1556"/>
            <end position="1576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1577"/>
            <end position="1589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005000744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1941" mass="214133" checksum="F51656E054E68111" modified="2022-01-19" version="1">MSSTSFSCAAVYTALASFGRDTYAAKGCTDPCPCLLGPDRVTTDFQPSKPTWPGGVKLRLKNRRSEAPGRPHSWHSTKLSENQPEPSMMQISQGMLGTPWLQSYHSSSSTSDLSGYEHGYLRRSPDQYSSQGSMESLDHSSPGYHPCHLSPAKSTNSIDQLSHLHSKRDSAYSSFSTNSSIPEYAASPFSKEHSCSTDSMHSRSSLPEGMKQADIRYVKTVYDSQRRISEEYEVKSSALLPSSEARASLDGRSHGRLHNFSRNSTAPSWVQPGQGCSDSESKPHKGPPLPPTRSDSYAAIRHHERPSSCSGLDLNKPSRSQMKGSWSPLVSPLSQGPLLKTHFGEGQLHTVVEKSPESSPTMKPKQSYSQPGQPLLPTGVYPVPSPEPHYAQVPQPSASNNGTLFPALAKESGYSPSLPVSYDKGAASSTLDFDENGNQSTTNRSAVFYEPSVVERKHDAAAKLVQQKPHNTAGPEIYLSMSRKEEVLPSHKAAHSNRDTASPAQASKHSFQAPQIQPRDASERKNPYQSREDWEDESQADKNGNVQINERGAATHFQWGHNKSRQYSFSSLQNIPESSRRQSSSEPLENYSSAKLSYLKNSSKEERDHGGQRSNADPQAFVNQDEGKSMAPFHAVEPKYEEIPLQHPKTSDLGRSRLSSSSTQGVLYGKPDPSKSRCSVLEKVSKFEKREQNTHRPQSAGTPSFGQHYGLSRVSQPSNTKSSPNSPEDTRSKLSTLLPSEMNRVSSPSVRNGKLEEADWRCVELQMAASAKQARCNEYYGPCPESEAQIRVAQLPRSKSTFQLGGEPEKEVLWKDNIQDTHGSQLDTPFNRAYRNSIKDAQSRVLRATSFRRISPPFANMPKRAIQRPASAHVGMRSMAASPHTPKERHSVTPTEGSLSALDYSRTPHILRIGGRKRLTAEQKKRSYSEPEKMNEVGISDGEPSPFSFQKKGLHFVFPENTVADRRKIFERDGKASSTVNLSKPELKQLQQNALADYIERKMGKRPSSQDIGLLRERSHSSYLQAGGQDSQSLSSASSMNSLQDQNLFRRRESIERVARTGRVSSTLPPGLTGCFDASVEEQKKGHRDSTIMSRLKTDRCRDYRAKMELTKGTQTDPLCPQGQPCYGKKERSSEAPRKSGKSVSVEDLLDRYDNQQRNACVPVHTRSRSSPTADKKHQDLLRKESSEFGAMVRDPFYVISAGARSFSKQERRHSEKMTFTSYYPHPRHISEIGTGSSTPTENHKVSELSRQESRSSAFVPSPTEARSHYPEQKQGFKSTFLIPPAFSQSSPSTAAQTPSDLQAAGDGQALRQHHAKQDAFAPGGSSTTQAQSVDAVQDRSLEAPAEEVACRRKAGLLQRSLPPRVMWAHSVKDNSLPHSMVPPPAEGPKFSQRWQSLPTQSSTSSDPETPSPQVTTHLRISESCLQLTPPPLLQDDEDDEVFIMPSQPAVTAPAFSPPLPPHPLPEQGSCTSVNGTEEFPPPPPPTALEEYGAAGDKSTRLTEDKVSSFKSFSKALAKREITGLGTNISENNWSFSPSLSKRTNSSPAVDKQHRSATSSERPQSSNGEPVTQSEGNNREPADITRDSENGSADPGTLNTCPPVKTKKKSPEDIKSEALAKEIVHKDKSLADILDPDSKMKTTMDLMEGLFPSGTSFLKENNMKRKMTQKKASRPVAEDNMKEEKEAPVTLVTCPAYYNVSAPKAELLNKIKDLPEEVGEEEDLLDINEKKAELIGSLTHKLEVLKEAKEGLLADIKMNNALGEEVELLISELCKPNEFDKYKMFIGDLDKVVNLLLSLSGRLARVENVLSSLGENANSEERSSLNEKRKLLAGQHEDARELKENLDRRERVVLEILGNYFSEEQLQDYQHFVKMKSALLIEQRELDDKIKLGQEQLKCLMESLPTDFTPRDATAAAALAAALATSAGVNGKTLPAVSSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y519</accession>
    <name>A0A8C2Y519_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MARCKS like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">MARCKSL1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MARCKS family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015739241.1">
        <property type="nucleotide sequence ID" value="XM_015883755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y519"/>
    <dbReference type="Ensembl" id="ENSCJPT00005000912.1">
        <property type="protein sequence ID" value="ENSCJPP00005000493.1"/>
        <property type="gene ID" value="ENSCJPG00005000589.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107324068"/>
    <dbReference type="KEGG" id="cjo:107324068"/>
    <dbReference type="CTD" id="65108"/>
    <dbReference type="GeneTree" id="ENSGT00730000111349"/>
    <dbReference type="OrthoDB" id="9948538at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008283">
        <property type="term" value="P:cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007417">
        <property type="term" value="P:central nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002101">
        <property type="entry name" value="MARCKS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14353:SF8">
        <property type="entry name" value="MARCKS-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14353">
        <property type="entry name" value="MYRISTOYLATED ALANINE-RICH C-KINASE SUBSTRATE MARCKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02063">
        <property type="entry name" value="MARCKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00963">
        <property type="entry name" value="MARCKS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00826">
        <property type="entry name" value="MARCKS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0519">Myristate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="100"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="137"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005000493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="214" mass="21382" checksum="C41D2313D4936C3E" modified="2022-01-19" version="1">MGSQGSKAAKAEGSDPPGENAAVAEPSKANGQENGHVRLNGDMTPKAGGDPTPLNGAGSAEPPREDGTGGAGGEDTIEPAPPADGGEAKPEGAAAPKETPKKKKKFSFKKSFKLSGISFRKNKKDDGDSAASSPTEEQSKAEPKAEEDPASGTAPQEERSGEGQSGAEPKGADGGQGEEEEKPPAETGGDAAAAQQPPEPTAAEPTAAAEQNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y642</accession>
    <name>A0A8C2Y642_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Vitelline membrane outer layer protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC107308353</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the VMO1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015707695.1">
        <property type="nucleotide sequence ID" value="XM_015852209.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y642"/>
    <dbReference type="Ensembl" id="ENSCJPT00005005853.1">
        <property type="protein sequence ID" value="ENSCJPP00005003265.1"/>
        <property type="gene ID" value="ENSCJPG00005003492.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107308353"/>
    <dbReference type="KEGG" id="cjo:107308353"/>
    <dbReference type="GeneTree" id="ENSGT00390000009313"/>
    <dbReference type="OrthoDB" id="6344411at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00220">
        <property type="entry name" value="VMO-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.100.10.20:FF:000001">
        <property type="entry name" value="Vitelline membrane outer layer 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.100.10.20">
        <property type="entry name" value="Vitelline membrane outer layer protein I (VOMI)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005515">
        <property type="entry name" value="VOMI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036706">
        <property type="entry name" value="VOMI_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18841:SF2">
        <property type="entry name" value="VITELLINE MEMBRANE OUTER LAYER PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18841">
        <property type="entry name" value="VITELLINE MEMBRANE OUTER LAYER PROTEIN I-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03762">
        <property type="entry name" value="VOMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51092">
        <property type="entry name" value="Vitelline membrane outer protein-I (VMO-I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034934741" evidence="6">
        <location>
            <begin position="21"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005003265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="183" mass="20043" checksum="C581A56465D12353" modified="2022-01-19" version="1">MKVLTAAALILLFFFYTVDAGTREYTSVITVPNGGHWGKWGIRQFCRSGYANGFALKVEPSQFGRDDTALNGIRLSCPDGSVIESLVGKWGTWTSFLVCPTGYLISFSLRMEKSQGGGDDTAANNIQFRCSGEAVLVGDGLSWGRFGPWSKRCKICGLQTKVESPQGLRDDTALNNVRFFCCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y6Q1</accession>
    <name>A0A8C2Y6Q1_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cholecystokinin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">CCK</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the gastrin/cholecystokinin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y6Q1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005007552.1">
        <property type="protein sequence ID" value="ENSCJPP00005004516.1"/>
        <property type="gene ID" value="ENSCJPG00005004461.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000003571"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005184">
        <property type="term" value="F:neuropeptide hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007586">
        <property type="term" value="P:digestion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015499">
        <property type="entry name" value="CCK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001651">
        <property type="entry name" value="Gastrin/CCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013152">
        <property type="entry name" value="Gastrin/cholecystokinin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10786">
        <property type="entry name" value="CHOLECYSTOKININ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10786:SF0">
        <property type="entry name" value="CHOLECYSTOKININ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00918">
        <property type="entry name" value="Gastrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00029">
        <property type="entry name" value="GASTRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00259">
        <property type="entry name" value="GASTRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0027">Amidation</keyword>
    <keyword evidence="5" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0765">Sulfation</keyword>
    <feature type="domain" description="Gastrin/cholecystokinin peptide hormone" evidence="9">
        <location>
            <begin position="53"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="86"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005004516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="179" mass="19402" checksum="614CA1B68FE9C350" modified="2022-01-19" version="1">MRTDPTALNCIKRTKFPQNAAPPKKTGLGDDAQCAPSFRPPDVPFLSPAMYGGICICVLLAALSVSSFGQQPAGSHDGSPLAAELQQSLTEPHRHNRSPSSAGPLKPAPRLDGSFEQRAAIGALLAKYLQQARKGSTGRFSVLGNRVQSIDPTHRINDRDYMGWMDFGRRSAEEYEYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y6T0</accession>
    <name>A0A8C2Y6T0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">ATP synthase subunit beta</fullName>
            <ecNumber evidence="18">7.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">ATP5F1B</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Catalytic subunit beta, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. With the subunit alpha (ATP5F1A), forms the catalytic core in the F(1) domain.</text>
    </comment>
    <comment type="function">
        <text evidence="18">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="16">
            <dbReference type="Rhea" id="RHEA:57722"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="18">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="18"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y6T0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005007757.1">
        <property type="protein sequence ID" value="ENSCJPP00005004684.1"/>
        <property type="gene ID" value="ENSCJPG00005004585.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00550000074800"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome LGE22C19W28_E50C23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043532">
        <property type="term" value="F:angiostatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042288">
        <property type="term" value="F:MHC class I protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001525">
        <property type="term" value="P:angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098761">
        <property type="term" value="P:cellular response to interleukin-7"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006933">
        <property type="term" value="P:negative regulation of cell adhesion involved in substrate-bound cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043536">
        <property type="term" value="P:positive regulation of blood vessel endothelial cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042776">
        <property type="term" value="P:proton motive force-driven mitochondrial ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd18110">
        <property type="entry name" value="ATP-synt_F1_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18115">
        <property type="entry name" value="ATP-synt_F1_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01133">
        <property type="entry name" value="F1-ATPase_beta_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1140.10:FF:000005">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.170:FF:000004">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12240:FF:000006">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000026">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="entry name" value="Bovine Mitochondrial F1-atpase, Atp Synthase Beta Chain, Chain D, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01347">
        <property type="entry name" value="ATP_synth_beta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005722">
        <property type="entry name" value="ATP_synth_F1_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050053">
        <property type="entry name" value="ATPase_alpha/beta_chains"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01039">
        <property type="entry name" value="atpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15184">
        <property type="entry name" value="ATP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15184:SF71">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039072">
        <property type="entry name" value="ATPase_subunit_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 18" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="8 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14 18" id="KW-0139">CF(1)</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="19">
        <location>
            <begin position="203"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00058650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU003553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005004684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="570" mass="60514" checksum="9267170C24F9D76E" modified="2022-01-19" version="1">MLGLAGRCSAAAASAALPALRRAAGPAHGFIPLLLSRGAGPAAAVGARRDHAAQAAPAAKAGSATGRIVAVIGAVVDVQFDEGLPPILNALEVQGRETRLVLEVAQHLGENTVRTIAMDGTEGLVRGQKVLDSGAPIRIPVGPETLGRIMNVIGEPIDERGPITTKQFAAIHAEAPEFVEMSVEQEILVTGIKVVDLLAPYAKGGKIGLFGGAGVGKTVLIMELINNVAKAHGGYSVFAGVGERTREGNDLYHEMIESGVINLKDATSKVALVYGQMNEPPGARARVALTGLTVAEYFRDQEGQDVLLFIDNIFRFTQAGSEVSALLGRIPSAVGYQPTLATDMGTMQERITTTRKGSITSVQAIYVPADDLTDPAPATTFAHLDATTVLSRAIAELGIYPAVDPLDSTSRIMDPNIVGPEHYDVARGVQKILQDYKSLQDIIAILGMDELSEEDKLTVARARKIQRFLSQPFQVAEVFTGHMGKLVPLKETIKGFKQILAGEEGGNEELGGFIPALVPAPPYYYSPPYYYGCIIPPAGEYDHLPEQAFYMVGPIEEAVAKAEKLAEEHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y775</accession>
    <name>A0A8C2Y775_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Claudin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">CLDN8</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell junction</location>
            <location evidence="8">Tight junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the claudin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y775"/>
    <dbReference type="Ensembl" id="ENSCJPT00005008300.1">
        <property type="protein sequence ID" value="ENSCJPP00005005057.1"/>
        <property type="gene ID" value="ENSCJPG00005004895.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159077"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016327">
        <property type="term" value="C:apicolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006187">
        <property type="entry name" value="Claudin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017974">
        <property type="entry name" value="Claudin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004031">
        <property type="entry name" value="PMP22/EMP/MP20/Claudin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12002">
        <property type="entry name" value="CLAUDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00822">
        <property type="entry name" value="PMP22_Claudin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01077">
        <property type="entry name" value="CLAUDIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01346">
        <property type="entry name" value="CLAUDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0965">Cell junction</keyword>
    <keyword evidence="3 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0796">Tight junction</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU060637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005005057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="145" mass="15630" checksum="EE166C6D3824E4D6" modified="2022-01-19" version="1">MINGALQIAGLLLGGLGMIGTFAVTGMPQWRVSAFIENNIIVFETIWEGLWMHCIRQANIRMQCKVYDSVLALSPDLQASRGLMCAGSVLSFLAFLVATVGMKCTRCRQSGWPTKGYILLAAGLLFILSVAMTAQLAGQRGVTLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y7H2</accession>
    <name>A0A8C2Y7H2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Acyltransferase</fullName>
            <ecNumber evidence="11">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">MOGAT2</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the diacylglycerol acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="11"/>
    <dbReference type="RefSeq" id="XP_015708080.1">
        <property type="nucleotide sequence ID" value="XM_015852594.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y7H2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005009664.1">
        <property type="protein sequence ID" value="ENSCJPP00005006094.1"/>
        <property type="gene ID" value="ENSCJPG00005005728.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107308595"/>
    <dbReference type="KEGG" id="cjo:107308595"/>
    <dbReference type="CTD" id="80168"/>
    <dbReference type="GeneTree" id="ENSGT01030000234582"/>
    <dbReference type="OrthoDB" id="264532at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990578">
        <property type="term" value="C:perinuclear endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003846">
        <property type="term" value="F:2-acylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006651">
        <property type="term" value="P:diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006640">
        <property type="term" value="P:monoacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07987">
        <property type="entry name" value="LPLAT_MGAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007130">
        <property type="entry name" value="DAGAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317:SF74">
        <property type="entry name" value="2-ACYLGLYCEROL O-ACYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317">
        <property type="entry name" value="DIACYLGLYCEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03982">
        <property type="entry name" value="DAGAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="335" mass="38269" checksum="EDE84802A310E6AC" modified="2022-01-19" version="1">MKIEFAPLSLPLQRRLQTAAVVQWVFSFLCLAQCCTAAFIALLFTRFWLLSVLYAAWWFTDREAPLRGGRRIHMVRNSAVWRHMKDFFPVSLVKTAELDPRQNYLVGFHPHGVLAVGAFINFGTEATGFSTIFPGITPHLMMLSLWFRVPFLRDYLMSGGLVSSDKESAYHVLQKPEGGNLLAIIVGGAQEALEARPGSCTLLLKNRKGFIRVAIERGTPLVPAFSFGENELFDQVSNPKGSWLRWIQHRLQQIMGISLPLFHARGIFQYSFGLVPYRRPVYTVIGKPIPVLKKHKPTEEEVDRVHQKYLEELSKLFEEHKAKYNVPEDSHLEFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y7L3</accession>
    <name>A0A8C2Y7L3_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Aminopeptidase</fullName>
            <ecNumber evidence="16">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LVRN</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="14 16">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14 16">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="16"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y7L3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005009993.1">
        <property type="protein sequence ID" value="ENSCJPP00005006322.1"/>
        <property type="gene ID" value="ENSCJPG00005005926.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160535"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome Z"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.50.20:FF:000006">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000001">
        <property type="entry name" value="Leucyl-cystinyl aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF31">
        <property type="entry name" value="AMINOPEPTIDASE Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 14 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 16" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 16" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 14 16" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="19">
        <location>
            <begin position="77"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="17">
        <location>
            <begin position="305"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="18">
        <location>
            <begin position="576"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="378"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="381"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="400"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="15">
        <location>
            <position position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU364040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="923" mass="105316" checksum="2975488315098D4A" modified="2022-01-19" version="1">MGARGGSGLYVGRGTAALVVAVLLSLLAVLFALAALYGRCRHPPLPSRPAAAPGPDPGVPGAPTAVSLRRLPRHLLPLHYELELWPRVRPGQEGPFGFSGQVNITVRCRRDTRSVVLHSAGLHNHRAAVLGPGAALEVEGLRLEEEGELAVLELREPLLAGRQYVLQLSFHGRLREDREGLFLTRYTDLGCSRYMLVASQLEPAYARTVYPCFDEPDMKATFNIRIVHDPSYMALSNMPPIDVSEMKDENGSLWSVTTFNTSLKMSTYLTAFVVCDFDYVNRTERGIEIRIWARKEAVKNGYVDYALNITGPIFSFLEDLFNISYPLPKIDLVALPEFGAGAMENWGLMTFEESALLYLPNDKFTGRKTIIALIVSHELAHQWFGNLVTMTWWNDLWLKEGLASYLENLGVTFVEPKLSLVKREDKVNGSFSLASLFDSITYNKGASITWMLSGFLTEKLFTRALNSYLKEFAFSNANQDDLWTHIQLVIDTQDEVQLPASVKKIMDSWTCQNGFPVLTVNITTGTISQEKFHNKNNTWIVPISWMRNGSSQPLMWLDNSSKVFPEMQVSESEYDWILLNVNLSGYYRVHYDQLNLKRLVHLLENDPKAIPAVSRFQLLDDMFALTQSGYTEIEAALELTKYLAGEDELFIWNVVLANLVPDNVESTLKSYEVYPLLKKYLLKRMLPIYRYYAGFIRQNVDALEDDYFAQVYLEKFLATACWLGLQDCLDLSSELYTKWMDNPEYKIPFLIRRTVCCYGVAVGSEQEWDFAWEMYKHNDSTTEDKDILLSAMSCAKESWLLHRSLRYGLSDARFSSNCTTNILEYVVSKDTGHRIAWEFVTENWSLLSERYGKEILHVVLKIMGRFVNTDVQIQELQVFYNNTLEEDERETATLLLETAKTENMERKELLTRVADWLDKNIDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y891</accession>
    <name>A0A8C2Y891_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Prosaposin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Saposin-B stimulates the hydrolysis of galacto-cerebroside sulfate by arylsulfatase A (EC 3.1.6.8), GM1 gangliosides by beta-galactosidase (EC 3.2.1.23) and globotriaosylceramide by alpha-galactosidase A (EC 3.2.1.22). Saposin-B forms a solubilizing complex with the substrates of the sphingolipid hydrolases.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Saposin-D is a specific sphingomyelin phosphodiesterase activator (EC 3.1.4.12).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y891"/>
    <dbReference type="Ensembl" id="ENSCJPT00005011320.1">
        <property type="protein sequence ID" value="ENSCJPP00005007307.1"/>
        <property type="gene ID" value="ENSCJPG00005006740.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156695"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007193">
        <property type="term" value="P:adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019216">
        <property type="term" value="P:regulation of lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.225.10">
        <property type="entry name" value="Saposin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003119">
        <property type="entry name" value="SAP_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007856">
        <property type="entry name" value="SapB_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008373">
        <property type="entry name" value="Saposin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011001">
        <property type="entry name" value="Saposin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008139">
        <property type="entry name" value="SaposinB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051428">
        <property type="entry name" value="Sphingo_Act-Surfact_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11480:SF36">
        <property type="entry name" value="PROSAPOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11480">
        <property type="entry name" value="SAPOSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02199">
        <property type="entry name" value="SapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05184">
        <property type="entry name" value="SapB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01797">
        <property type="entry name" value="SAPOSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00741">
        <property type="entry name" value="SapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47862">
        <property type="entry name" value="Saposin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51110">
        <property type="entry name" value="SAP_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50015">
        <property type="entry name" value="SAP_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0458">Lysosome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034435399" description="Prosaposin" evidence="11">
        <location>
            <begin position="25"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin A-type" evidence="13">
        <location>
            <begin position="23"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="12">
        <location>
            <begin position="61"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005007307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="289" mass="31429" checksum="720CB1B6526A8E22" modified="2022-01-19" version="1">MAATLGIHMCAWVLMFSSPPPAGASPLPECGEQPEEWCRDVGTAAKCGVLELCRLTVWDQKGVPCHLCQVVVSMMGKILQDNSTEEKLRVFLDKRCQYLPFQDWSVKCKKMVDTGVLILAQLDPKVVCGTIKLCQRQGGREGALKFQEQPPAPADPAQDLAQLAVPFINGIPLLLQPQDLPHTQDTGDLCEDCARLVAAVQLELSNGATTARSLVARAKEECEDTALTLLLCEDGHSLQKDANPALQGWDVGFPTFRAAWAGIPSPGHGMQHGVTFNLLVGEPCWNIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y9Y5</accession>
    <name>A0A8C2Y9Y5_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sorting nexin 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">SNX3</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y9Y5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005016015.1">
        <property type="protein sequence ID" value="ENSCJPP00005010897.1"/>
        <property type="gene ID" value="ENSCJPG00005009424.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153609"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032009">
        <property type="term" value="C:early phagosome"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019903">
        <property type="term" value="F:protein phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905394">
        <property type="term" value="F:retromer complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046597">
        <property type="term" value="P:host-mediated suppression of symbiont invasion"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070676">
        <property type="term" value="P:intralumenal vesicle formation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034499">
        <property type="term" value="P:late endosome to Golgi transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010324">
        <property type="term" value="P:membrane invagination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000642">
        <property type="term" value="P:negative regulation of early endosome to late endosome transport"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050765">
        <property type="term" value="P:negative regulation of phagocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042177">
        <property type="term" value="P:negative regulation of protein catabolic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051224">
        <property type="term" value="P:negative regulation of protein transport"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022615">
        <property type="term" value="P:protein to membrane docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030111">
        <property type="term" value="P:regulation of Wnt signaling pathway"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009617">
        <property type="term" value="P:response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051074">
        <property type="entry name" value="Sorting_Nexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45963">
        <property type="entry name" value="RE52028P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45963:SF1">
        <property type="entry name" value="SORTING NEXIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="5">
        <location>
            <begin position="27"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005010897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="197" mass="22314" checksum="ED3BAAF9635FC52F" modified="2022-01-19" version="1">MAETIADTRRLISKPQNLNDAYGPPSNFLEIDVGNPQTVGVGRGRFTTYEIRVKTNLPIFKLKESTVRRRYSDFEWLRNELERESKVVVPPLPGKALLRQLPFRGDDGIFDDSFIEERKQALEQFINNFPPTGRIHSHKGDHSASMQRGKEHPCNLWKCCCCSPQHSGTFLVTVCVNRRESPGDEVFSGDVGGTYVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YC92</accession>
    <name>A0A8C2YC92_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Meleagrin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC107312344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015715141.1">
        <property type="nucleotide sequence ID" value="XM_015859655.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YC92"/>
    <dbReference type="Ensembl" id="ENSCJPT00005022302.1">
        <property type="protein sequence ID" value="ENSCJPP00005015788.1"/>
        <property type="gene ID" value="ENSCJPG00005013036.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107312344"/>
    <dbReference type="KEGG" id="cjo:107312344"/>
    <dbReference type="GeneTree" id="ENSGT01150000287208"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.360.10">
        <property type="entry name" value="Antimicrobial Peptide, Beta-defensin 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012573">
        <property type="entry name" value="Meleagrin/Cygnin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08189">
        <property type="entry name" value="Meleagrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034698776" evidence="1">
        <location>
            <begin position="23"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="65" mass="7054" checksum="6573248378F69D18" modified="2022-01-19" version="1">MRFICLVFAVLLLVSLAAPGYGLFLKHCPEKIGRCSAKCSKAEVSATSPNCKGHCCLPAGWKKWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YCB4</accession>
    <name>A0A8C2YCB4_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ankyrin repeat and SOCS box containing 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ASB14</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015730372.1">
        <property type="nucleotide sequence ID" value="XM_015874886.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032303107.1">
        <property type="nucleotide sequence ID" value="XM_032447216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YCB4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005022771.1">
        <property type="protein sequence ID" value="ENSCJPP00005016161.1"/>
        <property type="gene ID" value="ENSCJPG00005013304.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107319771"/>
    <dbReference type="KEGG" id="cjo:107319771"/>
    <dbReference type="CTD" id="142686"/>
    <dbReference type="GeneTree" id="ENSGT00940000156550"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03730">
        <property type="entry name" value="SOCS_ASB14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.750.20:FF:000001">
        <property type="entry name" value="Ankyrin repeat and SOCS box containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.750.20">
        <property type="entry name" value="SOCS box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036036">
        <property type="entry name" value="SOCS_box-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF176">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX CONTAINING 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00253">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158235">
        <property type="entry name" value="SOCS box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="118"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="151"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="184"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="217"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="250"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="315"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="387"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="5">
        <location>
            <begin position="531"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005016161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="594" mass="66415" checksum="6DC8513B99D11B67" modified="2022-01-19" version="1">MYNSIYIFDDHSDDEIPTQQAIQESLQDIHKMERSASATEDESFLCVASKEREEIIAAIRAGQEEALKKLVRHSSAFEEADQQGWLPVHEAAAQLNKNILEITLKASPAATWEQTTLRGETPLMVAVRNCLLENVHFLLLNGCNPNIKNEDGDSPLVVAIKHNSYEVASLLINFGAKVNLQCMHKRTALHEAARLGRKDLVMLLLHSGADPDPRSGYGLTPLALAAQAGHTEIMELLLKKGADVLSQAMDYSSVLFEAAGGGNPDSLNLLLEYGADANVPKHSGHLPIHRAAYRGHFLALKNLVPVTDFDAIKESGISPVHSAAAGAHPQCLEFLLKSGFDANFMLDQRIRKGYDDRRKSALYFAVSNGDINSAQLLLNAGALPNQDPINCLQIALRMGNYELMNLLLRHGANVNYFCRVNTTHFPSALQYALKDEVMLRMLMNYGYDVQRCFDCPRGDVSHSQYVTDGWTSTVIKDTKFCEVITLSWLKHLSGKVVRVMLDYVDHVNICWKLEAALKEQELWPDINSILTNPRSLKHLCRLKIRECMGRLRLRCPVFMTFLPLPKCLKDYILYKEYDLYGPESFLGTSSVNCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YCI8</accession>
    <name>A0A8C2YCI8_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ankyrin repeat domain-containing protein 54</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ANKRD54</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Plays an important role in regulating intracellular signaling events associated with erythroid terminal differentiation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Midbody</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2YCI8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005023315.1">
        <property type="protein sequence ID" value="ENSCJPP00005016605.1"/>
        <property type="gene ID" value="ENSCJPG00005013629.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157805"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045648">
        <property type="term" value="P:positive regulation of erythrocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000108">
        <property type="entry name" value="Ankyrin repeat domain-containing protein 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000162">
        <property type="entry name" value="Ankyrin repeat domain-containing protein 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24197:SF44">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24197">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="213"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="246"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005016605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="370" mass="40003" checksum="2943E176967E9006" modified="2022-01-19" version="1">MLPRRARTGPTNPPPSPQPAPRSHIVVVVLPRVGHGAARGLGRQEEEVGPSGTLRKAGRICLVSLLVKITACLQRLFSLIAESACPSALCQRRPFPPLPSHPVPPGPAREGMEAESAAGTESESALGAGMALGGAAGEASLGYLHVLWQREEPAGKIPARRLRRAARIHRRLGPTGKESHALKRLREAANGNDLDTVQQLLEDGTDPCAADDKGRTALHFASCNGNDHIVQLLLDHGADPNQRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNILQEGISHSLEAVRLEVKQIIQMLREYLDRLGRHEQKEQLDDLCSKLQMTSTKEQVDEVTDLLASFTSLSLQMQMEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YGQ5</accession>
    <name>A0A8C2YGQ5_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine rich and transmembrane domain containing 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">SERTM1</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015707443.1">
        <property type="nucleotide sequence ID" value="XM_015851957.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015707444.1">
        <property type="nucleotide sequence ID" value="XM_015851958.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YGQ5"/>
    <dbReference type="SMR" id="A0A8C2YGQ5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005034474.1">
        <property type="protein sequence ID" value="ENSCJPP00005025334.1"/>
        <property type="gene ID" value="ENSCJPG00005019893.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107308219"/>
    <dbReference type="CTD" id="400120"/>
    <dbReference type="GeneTree" id="ENSGT00390000016881"/>
    <dbReference type="OrthoDB" id="9397689at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031741">
        <property type="entry name" value="SERTM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35660">
        <property type="entry name" value="SERINE-RICH AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35660:SF1">
        <property type="entry name" value="SERINE-RICH AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15872">
        <property type="entry name" value="SRTM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005025334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="107" mass="11499" checksum="6BC4B32F781391EC" modified="2022-01-19" version="1">MSEPDPSSGFVGNMENGTFLELYPTSLSTSVDSSPGRLSNVYVYVSIFLSLLAFLLLLLIIALQRLKNIISSSSSYPEYNSDAGSSFTNLEVCSISSQRSALSNLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YGX2</accession>
    <name>A0A8C2YGX2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Triacylglycerol lipase</fullName>
            <ecNumber evidence="8">3.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Pancreatic lipase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC107316166</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17855"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.3" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2YGX2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005034869.1">
        <property type="protein sequence ID" value="ENSCJPP00005025659.1"/>
        <property type="gene ID" value="ENSCJPG00005020109.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155139"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004465">
        <property type="term" value="F:lipoprotein lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00707">
        <property type="entry name" value="Pancreat_lipase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000033">
        <property type="entry name" value="Pancreatic triacylglycerol lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.60.20">
        <property type="entry name" value="PLAT/LH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013818">
        <property type="entry name" value="Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016272">
        <property type="entry name" value="Lipase_LIPH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033906">
        <property type="entry name" value="Lipase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002331">
        <property type="entry name" value="Lipase_panc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036392">
        <property type="entry name" value="PLAT/LH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000734">
        <property type="entry name" value="TAG_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610:SF100">
        <property type="entry name" value="PANCREATIC LIPASE-RELATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00151">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000865">
        <property type="entry name" value="Lipoprotein_lipase_LIPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00823">
        <property type="entry name" value="PANCLIPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00821">
        <property type="entry name" value="TAGLIPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49723">
        <property type="entry name" value="Lipase/lipooxygenase domain (PLAT/LH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Lipase" evidence="9">
        <location>
            <begin position="17"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="279"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000865-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000865-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005025659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="450" mass="50113" checksum="653EDC7FF7918834" modified="2022-01-19" version="1">DCPPWVLDYSSSAIGDEVCYPRLGCFSNDPPWSGIPGRLLTGLPESPEEMNISFSLYTRETGNNSQVISAINSSTIQNSHFSSHRRTSFIIHGFSSTGKKGWVVEMCLLLLEVENMNCIAVDWKEGAKGTYVSAVNNIRVIGAEVAYFIKTLQKLFRYSPREIHLIGHSLGAHTAGEAGRRVRGIRRISGLDPAGPYFEGTPPEVRLDPTDADFVDVIHSNAAHFPATGLGMYNTTGHLDFYPNGGTQMPGCNDLLLKMKRSDFEDRLADTTIFGSCHHSRSHDFYFKSILYPTGFVGYPCETYEDFKSGKCFPCPKQGCPMMGYYADRFPYKLKRVNQKYFLNTAADPPFASKSMTFVIGPISLHHCCLRSISSGVLSDDKVYTKYLDVEIDPKKTKKVEFLWNKTMFTLLWARMGAEAVNIIHGEDGRSTFCGHGTVTYGVPQLLTPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YHV4</accession>
    <name>A0A8C2YHV4_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Regulator of G-protein signaling 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">RGS8</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Dendrite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Perikaryon</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2YHV4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005037376.1">
        <property type="protein sequence ID" value="ENSCJPP00005027688.1"/>
        <property type="gene ID" value="ENSCJPG00005021428.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154304"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043204">
        <property type="term" value="C:perikaryon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009968">
        <property type="term" value="P:negative regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08711">
        <property type="entry name" value="RGS_RGS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.167.10:FF:000001">
        <property type="entry name" value="Putative regulator of g-protein signaling 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.196.10:FF:000001">
        <property type="entry name" value="Regulator of G-protein signaling 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.196.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034949">
        <property type="entry name" value="RGS_RGS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024066">
        <property type="entry name" value="RGS_subdom1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845:SF147">
        <property type="entry name" value="REGULATOR OF G-PROTEIN SIGNALING 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01301">
        <property type="entry name" value="RGSPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0734">Signal transduction inhibitor</keyword>
    <feature type="domain" description="RGS" evidence="12">
        <location>
            <begin position="72"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005027688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="196" mass="22744" checksum="6AFE53F52DC5FB12" modified="2022-01-19" version="1">KHVARGDCKRGHHVGTHPSCQREKGNRGMRTRLGCLSHKSDSYNDFTAILPDKPNRALKRLSTEEATRWADSFDVLLSHKYGLAAFRAFLKTEFSEENLEFWLACEDFKKTRSAAKLAAKAQRIFEEFIDVQAPREVNIDFQTRELTRRNMQEPSLSCFDQAQGKVHSLMEKDSYPRFLRSKIYTDLLSQTQRRLS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1999-07-15" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>O57571</accession>
    <name>IFNG_COTJA</name>
    <protein>
        <recommendedName>
            <fullName>Interferon gamma</fullName>
            <shortName>IFN-gamma</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">IFNG</name>
    </gene>
    <organism>
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="1997-10" db="EMBL/GenBank/DDBJ databases">
            <title>Avian interferon-gamma: cloning, sequencing and comparison of interferon-gamma genes from several different avian species.</title>
            <authorList>
                <person name="Kaiser P."/>
                <person name="Sonnemans D."/>
                <person name="Smith L.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the type II (or gamma) interferon family.</text>
    </comment>
    <dbReference type="EMBL" id="AJ001678">
        <property type="protein sequence ID" value="CAA04918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O57571"/>
    <dbReference type="SMR" id="O57571"/>
    <dbReference type="GlyCosmos" id="O57571">
        <property type="glycosylation" value="2 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="AgBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005133">
        <property type="term" value="F:type II interferon receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006959">
        <property type="term" value="P:humoral immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042116">
        <property type="term" value="P:macrophage activation"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="AgBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070673">
        <property type="term" value="P:response to interleukin-18"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="AgBase"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.10:FF:000007">
        <property type="entry name" value="Interferon gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009079">
        <property type="entry name" value="4_helix_cytokine-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002069">
        <property type="entry name" value="Interferon_gamma"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11419">
        <property type="entry name" value="INTERFERON GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11419:SF0">
        <property type="entry name" value="INTERFERON GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00714">
        <property type="entry name" value="IFN-gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001936">
        <property type="entry name" value="IFN-gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47266">
        <property type="entry name" value="4-helical cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52076">
        <property type="entry name" value="IFN_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0051">Antiviral defense</keyword>
    <keyword id="KW-0202">Cytokine</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0341">Growth regulation</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000016464" description="Interferon gamma">
        <location>
            <begin position="20"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="42"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="164" mass="18898" checksum="F47C47D29A06D1A0" modified="1998-06-01" version="1" precursor="true">MTCQTYNLFVLSVIMIYYGHTASSLNLVQLQDDIDKLKADFNSSHSDVADGGPIIVEKLKNWTERNEKRIILSQIVSMYLEMLENTDKSKPHIKHISEELYTLKNNLNDGTKKVKDIMDLAKLQMNDLRIHRKAANDLFSVLQKLVDPPSSKRKRSQCLRRCSC</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-02-11" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q9DDF1</accession>
    <accession>A0A8C2TNH0</accession>
    <name>PCNA_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA sliding clamp PCNA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Proliferating cell nuclear antigen</fullName>
            <shortName>PCNA</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">PCNA</name>
    </gene>
    <organism>
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2000-11" db="EMBL/GenBank/DDBJ databases">
            <title>BMP-2 induces cDermo-1 expression and ectopic feather development.</title>
            <authorList>
                <person name="Scaal M."/>
                <person name="Prols F."/>
                <person name="Fuechtbauer E.M."/>
                <person name="Christ B."/>
                <person name="Brand-Saberi B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Confers DNA tethering and processivity to DNA polymerases and other proteins. Auxiliary protein of DNA polymerase delta and epsilon, is involved in the control of DNA replication by increasing the polymerases' processivity during elongation of the leading strand.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotrimer. Forms a complex with the replication factor C complex in the presence of ATP (By similarity). Component of the replisome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">Monoubiquitinated by the UBE2B-RAD18 complex on Lys-164. Monoubiquitination at Lys-164 also takes place in undamaged proliferating cells, and is mediated by the DCX(DTL) complex, leading to enhance PCNA-dependent translesion DNA synthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PCNA family.</text>
    </comment>
    <dbReference type="EMBL" id="AJ301669">
        <property type="protein sequence ID" value="CAC17700.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001310154.1">
        <property type="nucleotide sequence ID" value="NM_001323225.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005020430.1">
        <property type="protein sequence ID" value="ENSCJPP00005014338.1"/>
        <property type="gene ID" value="ENSCJPG00005011978.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107323623"/>
    <dbReference type="KEGG" id="cjo:107323623"/>
    <dbReference type="CTD" id="5111"/>
    <dbReference type="GeneTree" id="ENSGT00390000004965"/>
    <dbReference type="OrthoDB" id="534348at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043626">
        <property type="term" value="C:PCNA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070557">
        <property type="term" value="C:PCNA-p21 complex"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030337">
        <property type="term" value="F:DNA polymerase processivity factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019985">
        <property type="term" value="P:translesion synthesis"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="CDD" id="cd00577">
        <property type="entry name" value="PCNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.70.10.10:FF:000001">
        <property type="entry name" value="Proliferating cell nuclear antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00317">
        <property type="entry name" value="DNApol_clamp_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000730">
        <property type="entry name" value="Pr_cel_nuc_antig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022649">
        <property type="entry name" value="Pr_cel_nuc_antig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022659">
        <property type="entry name" value="Pr_cel_nuc_antig_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022648">
        <property type="entry name" value="Pr_cel_nuc_antig_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00590">
        <property type="entry name" value="pcna"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352">
        <property type="entry name" value="PROLIFERATING CELL NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352:SF0">
        <property type="entry name" value="PROLIFERATING CELL NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02747">
        <property type="entry name" value="PCNA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00705">
        <property type="entry name" value="PCNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00339">
        <property type="entry name" value="PCNACYCLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01251">
        <property type="entry name" value="PCNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00293">
        <property type="entry name" value="PCNA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0235">DNA replication</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1017">Isopeptide bond</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0832">Ubl conjugation</keyword>
    <feature type="chain" id="PRO_0000149162" description="DNA sliding clamp PCNA">
        <location>
            <begin position="1"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="DNA-binding region" evidence="3">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)" evidence="1">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P12004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3"/>
    <evidence type="ECO:0000305" key="4"/>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005014338.1"/>
        </source>
    </evidence>
    <sequence length="262" mass="28918" checksum="8A8064CA65D0473B" modified="2026-01-28" version="2">MFEARLVQGSVLKRVLEALKDLITEACWDLGSGGISLQSMDSSHVSLVQLTLRSEGFDTYRCDRNIAMGVNLNSMSKILKCAGNEDIITLRAEDNADTLALVFETPNQEKVSDYEMKLMDLDVEQLGIPEQEYSCVVKMPSAEFARICRDLSHIGDAVVISCAKDGVKFSANGELGNGNIKLSQTSNVDKEEEAVTIEMNEPVQLTFALRYLNFFTKATPLSPTVTLSMSADVPLVVEYKIADMGHLKYYLAPKIEDQQEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SK72</accession>
    <name>A0A8C2SK72_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Filamin-B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC107307409</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the filamin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SK72"/>
    <dbReference type="Ensembl" id="ENSCJPT00005000289.1">
        <property type="protein sequence ID" value="ENSCJPP00005000127.1"/>
        <property type="gene ID" value="ENSCJPG00005000213.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153588"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044801">
        <property type="entry name" value="Filamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001298">
        <property type="entry name" value="Filamin/ABP280_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38537:SF12">
        <property type="entry name" value="FILAMIN-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38537">
        <property type="entry name" value="JITTERBUG, ISOFORM N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00630">
        <property type="entry name" value="Filamin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00557">
        <property type="entry name" value="IG_FLMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50194">
        <property type="entry name" value="FILAMIN_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="10"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="80"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005000127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="175" mass="18700" checksum="189420F1354223F8" modified="2025-10-08" version="2">MGSSGFQWGHRVTYTPMAPGNYLISIKYGGPHHIVGSPFKAKVTGPRLSGGHSLHETSSVLVETVTRGSRGPPSFGGLPKFSSDASKVVARGPGLSTAFVGQKNHFTVDCSKAGSNMLMVGVHGPKTPCEEVYVKHVGNRLYNVTYTVKEKGDYVLILRWGDDSVPGSPFRVTVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SM96</accession>
    <name>A0A8C2SM96_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Fibrinogen gamma chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">FGG</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="11">Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SM96"/>
    <dbReference type="Ensembl" id="ENSCJPT00005000665.1">
        <property type="protein sequence ID" value="ENSCJPP00005000353.1"/>
        <property type="gene ID" value="ENSCJPG00005000435.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158467"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005577">
        <property type="term" value="C:fibrinogen complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031091">
        <property type="term" value="C:platelet alpha granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005201">
        <property type="term" value="F:extracellular matrix structural constituent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072377">
        <property type="term" value="P:blood coagulation, common pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042730">
        <property type="term" value="P:fibrinolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000352">
        <property type="term" value="P:negative regulation of endothelial cell apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902042">
        <property type="term" value="P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031639">
        <property type="term" value="P:plasminogen activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070527">
        <property type="term" value="P:platelet aggregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070374">
        <property type="term" value="P:positive regulation of ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045921">
        <property type="term" value="P:positive regulation of exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034116">
        <property type="term" value="P:positive regulation of heterotypic cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090277">
        <property type="term" value="P:positive regulation of peptide hormone secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050714">
        <property type="term" value="P:positive regulation of protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045907">
        <property type="term" value="P:positive regulation of vasoconstriction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051258">
        <property type="term" value="P:protein polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051592">
        <property type="term" value="P:response to calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.50:FF:000003">
        <property type="entry name" value="Fibrinogen gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.215.10:FF:000002">
        <property type="entry name" value="Fibrinogen gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.530.10:FF:000002">
        <property type="entry name" value="Fibrinogen gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.530.10">
        <property type="entry name" value="Gamma-fibrinogen Carboxyl Terminal Fragment, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037579">
        <property type="entry name" value="FIB_ANG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012290">
        <property type="entry name" value="Fibrinogen_a/b/g_coil_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020837">
        <property type="entry name" value="Fibrinogen_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47221">
        <property type="entry name" value="FIBRINOGEN ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47221:SF9">
        <property type="entry name" value="FIBRINOGEN GAMMA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08702">
        <property type="entry name" value="Fib_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01212">
        <property type="entry name" value="Fib_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58010">
        <property type="entry name" value="Fibrinogen coiled-coil and central regions"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00514">
        <property type="entry name" value="FIBRINOGEN_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0094">Blood coagulation</keyword>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0356">Hemostasis</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034555510" evidence="13">
        <location>
            <begin position="26"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="14">
        <location>
            <begin position="169"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="104"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005000353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="435" mass="49776" checksum="860982663679166B" modified="2022-01-19" version="1">HMGLKLGRWVPLGYLLSILFSTSMAYIATRENCCILDERFGSYCPTTCGIADFFNKYRLTTDGELLEIERLLQQAVNSTGSIEYLIQHIKTIYPSDKQTLPQSIESLTQKSKKIIEEIIRYENTILAHENTIQQLTDMHIMNSNKITQLKQKIAQLESHCQEPCKDTAEILETTGRDCQDIANKGARKSGLYFIKPQKAKQSFLVYCEIDTYGNGWTVLQRRLDGSEDFRRNWVQYKEGFGHLSPDDTTEFWLGNEKIHLITTQSTLPYTLRIELEDWSGNKGTADYAVFKVGSEEDKYRLTYAYFIGGDAGDAFDGFNFGDDPSDKSFTYHNGMRFSTYDNDNDKFEGNCAEQDGSGWWMNRCHAGHLNGKYYIGGVYSARDGDPDSYDNGIIWATWRDRWYSMKKTTMKIIPFNRLSIDGQQHSGGLKQVGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SPJ3</accession>
    <name>A0A8C2SPJ3_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Polyadenylate-binding protein</fullName>
            <shortName evidence="7">PABP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">PABPC1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Binds the poly(A) tail of mRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the polyadenylate-binding protein type-1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SPJ3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005001385.1">
        <property type="protein sequence ID" value="ENSCJPP00005000791.1"/>
        <property type="gene ID" value="ENSCJPG00005000858.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153773"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12378">
        <property type="entry name" value="RRM1_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12379">
        <property type="entry name" value="RRM2_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12380">
        <property type="entry name" value="RRM3_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12381">
        <property type="entry name" value="RRM4_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1900.10:FF:000001">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000003">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000091">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000154">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.10">
        <property type="entry name" value="c-terminal domain of poly(a) binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036053">
        <property type="entry name" value="PABP-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006515">
        <property type="entry name" value="PABP_1234"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002004">
        <property type="entry name" value="PABP_HYD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034364">
        <property type="entry name" value="PABP_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045305">
        <property type="entry name" value="RRM2_I_PABPs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01628">
        <property type="entry name" value="PABP-1234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00658">
        <property type="entry name" value="MLLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00517">
        <property type="entry name" value="PolyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63570">
        <property type="entry name" value="PABC (PABP) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51309">
        <property type="entry name" value="PABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 6 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="11"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="85"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="177"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="280"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="PABC" evidence="9">
        <location>
            <begin position="495"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005000791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="589" mass="65282" checksum="082FB23C83631FBF" modified="2022-01-19" version="1">MNPSAPSYPMASLYVGDLHPDVTEAMLYEKFSPAGPILSIRVCRDMITRRSLGYAYVNFQQPADGKPVRIMWSQRDPSLRKSGVGNIFIKNLDKSIDNKALYDTFSAFGNILSCKVVCDENGSKGYGFVHFETQEAAERAIEKMNGMLLNDRKVFVGRFKSRKEREAELGARAKEFTNVYIKNFGEDMDDERLKELFGKFGPALSVKVMTDESGKSKGFGFVSFERHEDAQKAVDEMNGKELNGKQIYVGRAQKKVERQTELKRKFEQMKQDRITRYQGVNLYVKNLDDGIDDERLRKEFSPFGTITSAKVMMEGGRSKGFGFVCFSSPEEATKAVTEMNGRIVATKPINPYQPAPPSGYFMAAIPQTQNRAAYYPTNQLAQLARPSPRWTAQGARPHPFQNMPGAIRPAAPRPPFSTMRPAPTQVPRGMSTQRVANTATQTMGPRPAAAATAATPAVRTVPQYKYAAGVRNPQQHLNTQPQVAMQQPAVHVQGQEPLTASMLASAPPQEQKQMLGERLFPLIQSMHPTLAGKITGMLLEIDNSELLHMLESPESLRSKVDEAVAVLQAHQAKEAAQKAVNNPTGVPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SPW3</accession>
    <name>A0A8C2SPW3_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">26S proteasome regulatory subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">26S proteasome AAA-ATPase subunit RPT2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Proteasome 26S subunit ATPase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">PSMC1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015720837.1">
        <property type="nucleotide sequence ID" value="XM_015865351.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SPW3"/>
    <dbReference type="SMR" id="A0A8C2SPW3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005000540.1">
        <property type="protein sequence ID" value="ENSCJPP00005000279.1"/>
        <property type="gene ID" value="ENSCJPG00005000367.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107315228"/>
    <dbReference type="CTD" id="5700"/>
    <dbReference type="GeneTree" id="ENSGT01020000230346"/>
    <dbReference type="OrthoDB" id="10255768at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005838">
        <property type="term" value="C:proteasome regulatory particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000067">
        <property type="entry name" value="26S protease regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000007">
        <property type="entry name" value="26S proteasome regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000039">
        <property type="entry name" value="26S proteasome regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="218"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00070503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00079970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005000279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="440" mass="49199" checksum="ACA80683F4F86E49" modified="2022-01-19" version="1">MGQSQSGGHGPGGGKKDDKDKKKKYEPPVPTRVGKKKKKTKGPDAASKLPLVTPHTQCRLKLLKLERIKDYLLMEEEFIRNQEQMKPLEEKQEEERSKVDDLRGTPMSVGTLEEIIDDNHAIVSTSVGSEHYVSILSFVDKDLLEPGCSVLLNHKVHAVIGVLMDDTDPLVTVMKVEKAPQETYADIGGLDNQIQEIKESVELPLTHPEYYEEMGIKPPKGVILYGPPGTGKTLLAKAVANQTSATFLRVVGSELIQKYLGDGPKLVRELFRVAEEHAPSIVFIDEIDAIGTKRYDSNSGGEREIQRTMLELLNQLDGFDSRGDVKVIMATNRIETLDPALIRPGRIDRKIEFPLPDEKTKKRIFQIHTSRMTLADDVTLDELIMAKDDLSGADIKAICTEAGLMALRERRMKVTNEDFKKSKENVLYKKQEGTPEGLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SST7</accession>
    <name>A0A8C2SST7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Serine/threonine-protein kinase PLK</fullName>
            <ecNumber evidence="16">2.7.11.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Polo-like kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">PLK2</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.21"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Dendrite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.21" evidence="16"/>
    <dbReference type="RefSeq" id="XP_015704270.1">
        <property type="nucleotide sequence ID" value="XM_015848784.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SST7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005002482.1">
        <property type="protein sequence ID" value="ENSCJPP00005001503.1"/>
        <property type="gene ID" value="ENSCJPG00005001516.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107306024"/>
    <dbReference type="KEGG" id="cjo:107306024"/>
    <dbReference type="CTD" id="10769"/>
    <dbReference type="GeneTree" id="ENSGT00940000158739"/>
    <dbReference type="OrthoDB" id="408964at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome Z"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043008">
        <property type="term" value="F:ATP-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007613">
        <property type="term" value="P:memory"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016525">
        <property type="term" value="P:negative regulation of angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071866">
        <property type="term" value="P:negative regulation of apoptotic process in bone marrow cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000773">
        <property type="term" value="P:negative regulation of cellular senescence"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090050">
        <property type="term" value="P:positive regulation of cell migration involved in sprouting angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045732">
        <property type="term" value="P:positive regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046599">
        <property type="term" value="P:regulation of centriole replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048167">
        <property type="term" value="P:regulation of synaptic plasticity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd13118">
        <property type="entry name" value="POLO_box_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13117">
        <property type="entry name" value="POLO_box_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14188">
        <property type="entry name" value="STKc_PLK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001498">
        <property type="entry name" value="Serine/threonine-protein kinase PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1120.30:FF:000001">
        <property type="entry name" value="Serine/threonine-protein kinase PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000091">
        <property type="entry name" value="Serine/threonine-protein kinase PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.30">
        <property type="entry name" value="POLO box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042825">
        <property type="entry name" value="PLK2_STKc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033701">
        <property type="entry name" value="POLO_box_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033695">
        <property type="entry name" value="POLO_box_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000959">
        <property type="entry name" value="POLO_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036947">
        <property type="entry name" value="POLO_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF44">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PLK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00659">
        <property type="entry name" value="POLO_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82615">
        <property type="entry name" value="Polo-box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50078">
        <property type="entry name" value="POLO_BOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 15 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 16" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="70"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="POLO box" evidence="19">
        <location>
            <begin position="489"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="POLO box" evidence="19">
        <location>
            <begin position="587"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="27"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005001503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="671" mass="76629" checksum="0C1141D74F4C81CA" modified="2022-01-19" version="1">MELLRTIAYPPGGSGASSNTAAARGCEAAVGRASSAEPRRKKAEEQPHQHAHPAAEVSRIITDPATGKRYCRGKVLGKGGFAKCYEMTDLTTNKVYAAKIIPHSRVAKPHQREKIDKEIELHRMLNHRHVVQFYHYFEDRENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLGNFFINENMELKLGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGHGCESDIWALGCVMYTMLLGRPPFETTNLKETYRCIREARYSLPSSLLAPAKHLIASMLSKNPEDRPSLDEIMRHDFFVQGFTPDRLSASCCHTVPDFHLSSPAKNFFKKAAAALFGGKKDKARYFDNHNRLAKEDEEIYKLRHDLKKTSITQQPHKHRTDEEIQPLITTVAKPQALPETKQIGDSIRMIVRGTLGSCSSSSECLEDSTMGSVADTVARVLRGCLENMPEADSIPKEQLTTSFQWVTKWVDYSNKYGFGYQLSDHTVGVLFNNGAHMSLLPDKKTVHYYAELGQCSVFTAAEAPEQFISQVTILKYFSHYMEENLMDGGDLPSLTDVRRPRLYLLQWLKSDKALMMLFNDGTFQVNFYHDHTKIIICNQSEEYLLTYINEDRISTTFRLSTLLVSGCSLELKHRMEYALNMLLQRCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SSX1</accession>
    <name>A0A8C2SSX1_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">SWI/SNF related BAF chromatin remodeling complex subunit C2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">SMARCC2</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the SMARCC family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SSX1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005005950.1">
        <property type="protein sequence ID" value="ENSCJPP00005003329.1"/>
        <property type="gene ID" value="ENSCJPG00005003537.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155746"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome LGE22C19W28_E50C23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071565">
        <property type="term" value="C:nBAF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071564">
        <property type="term" value="C:npBAF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016514">
        <property type="term" value="C:SWI/SNF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048858">
        <property type="term" value="P:cell projection morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021877">
        <property type="term" value="P:forebrain neuron fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000020">
        <property type="entry name" value="SWI/SNF complex subunit SMARCC2 isoform c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000014">
        <property type="entry name" value="SWI/SNF complex subunit SMARCC2 isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049898">
        <property type="entry name" value="MARR_BRCT_CHROMO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032451">
        <property type="entry name" value="SMARCC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032450">
        <property type="entry name" value="SMARCC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032448">
        <property type="entry name" value="SWIRM-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15381:SF1">
        <property type="entry name" value="CHONDROITIN SULFATE PROTEOGLYCAN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15381">
        <property type="entry name" value="CHONDROITIN SULFATE PROTEOGLYCAN 5 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04433">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16495">
        <property type="entry name" value="SWIRM-assoc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16496">
        <property type="entry name" value="SWIRM-assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16498">
        <property type="entry name" value="SWIRM-assoc_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52032">
        <property type="entry name" value="MARR_BRCT_CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Chromo" evidence="11">
        <location>
            <begin position="1"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="SWIRM" evidence="9">
        <location>
            <begin position="477"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="10">
        <location>
            <begin position="650"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="8">
        <location>
            <begin position="655"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="310"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="784"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="997"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="328"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="384"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="801"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1011"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1021"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1043"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1057"/>
            <end position="1087"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005003329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1207" mass="132015" checksum="DD85C9A7DB61BD42" modified="2022-01-19" version="1">MPWWGGDTWDPPPSHPPPPLEGSLREPPRPHTAQLGGMDTWGPSSSPLPSLWGALWGWGWAGGLLGWSPPWHGAGTAMGTIGRRDESQCCPLWGIACYVWGIACCGALPAVGYCPLWGSPPPESSHPLFQIKCFLDFKAGGALCHILAAAYKFKSDQGWRRFDFQNPSRMDRNVEMFMTIEKSLVQNNCLSRPNIFLHQEIEPKLLSKLKDIIKRHQGTVTEDKSNASHVVCPVPGNLEEEEWVRPVMKRDKQVLLHWGYYPDSYDTWIPASEIEASVEDAPTPEKPRKVHAKWILDTDTFNEWMNEEDYEVSDEKSPVARRKKISAKTLTDEVNSPDSDRRDKKGGNYKKRKRSPSPSPTPEAKKKNAKKGPATPYNKSKRGHREEEQEDLTKDMDEPSPVPNVEEVTLPKTVNTKKDSESAPVKGGTMTDLDEQEDESMETAGKDEEENGTGSKGEQAKNPDLHEDNVTEQTHHIIIPSYAAWFDYNSVHAIERRALPEFFNGKNKSKTPEIYLAYRNFMIDTYRLNPQEYLTSTACRRNLAGDVCAIMRVHAFLEQWGLINYQVDAESRPTPMGPPPTSHFHVLADTPSGLVPLQPKTPQQQTSASQQMLNFPDKSKEKPADMQNFGLRTDMYTKKNIPSKSKAAASATREWTEQETLLLLEALEMYKDDWNKVSEHVGSRTQDECILHFLRLPIEDPYLEDSEASLGPLAYQPIPFSQSGNPVMSTVAFLASVVDPRVASAAAKSALEEFSKMKEEVPTALVEAHVRKVEEAAKVTGKADPAFGLESSGIAGTASEEPERIEEGGAEETRTETTPVEEKKEEPRDGAAEEEVKEKVGDVAKKEEEKSKEPEGEKEAEKGDSDSTGELEKEKEAKETQEETPKEPAEPEAERKAKVERDIGEGNLSTAAAAALAAAAVKAKHLAAVEERKIKSLVALLVETQMKKLEIKLRHFEELETIMDREREALEYQRQQLLADRQAFHMEQLKYAEMRARQQHFQHLQQQQQQQPPPLPPGAQPLPAAGTPLAPAAHPLAAPPTPAMVAPAEPGGQLMPGVPPPQPPPPPGAPQPGPAIPHAPVPFPGQQPPSQNLGGNLGGSGHPSMPGNAPTALPFAPPPSAIPLSMANPLADSIATTFPANPPALPLHGALASSMPPGGLPPPPPHPPGLALPLLGGGGSPAAHSPAIVAAVQGSLLPTPGLLAGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SUK3</accession>
    <name>A0A8C2SUK3_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RD3 like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">RD3L</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015721029.1">
        <property type="nucleotide sequence ID" value="XM_015865543.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015721030.1">
        <property type="nucleotide sequence ID" value="XM_015865544.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032301074.1">
        <property type="nucleotide sequence ID" value="XM_032445183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SUK3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005004968.1">
        <property type="protein sequence ID" value="ENSCJPP00005002673.1"/>
        <property type="gene ID" value="ENSCJPG00005002982.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107315314"/>
    <dbReference type="KEGG" id="cjo:107315314"/>
    <dbReference type="CTD" id="647286"/>
    <dbReference type="GeneTree" id="ENSGT00390000002089"/>
    <dbReference type="OrthoDB" id="9944259at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028092">
        <property type="entry name" value="RD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28489:SF3">
        <property type="entry name" value="PROTEIN RD3-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28489">
        <property type="entry name" value="RENTINAL DEGENERATION 3-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14473">
        <property type="entry name" value="RD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005002673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="195" mass="23178" checksum="821758CA0F175BB2" modified="2022-01-19" version="1">MPLFGWMKWPKNDPYKSSRYPGSELVTKTLLRELKWHLKERERLVQEIENEQKVQKTGMDYNWLKNYQNPQATIPATEQRQLEVLCSQIQPCQTGTVLSRFREVLAENDVLPWEIVYIFKQVLKDFLTTIERENQQEQLVNVWNTNCSKHCGDSSNRSEKEEIPTVSSYVDKNTQSMFPTFSDRIWNLPYYYPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SUQ1</accession>
    <name>A0A8C2SUQ1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glycosyltransferase 8 domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">GLT8D1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 8 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015729931.1">
        <property type="nucleotide sequence ID" value="XM_015874445.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SUQ1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005006977.1">
        <property type="protein sequence ID" value="ENSCJPP00005004090.1"/>
        <property type="gene ID" value="ENSCJPG00005004143.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107319542"/>
    <dbReference type="KEGG" id="cjo:107319542"/>
    <dbReference type="CTD" id="55830"/>
    <dbReference type="GeneTree" id="ENSGT00940000159273"/>
    <dbReference type="OrthoDB" id="411524at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06429">
        <property type="entry name" value="GT8_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000069">
        <property type="entry name" value="Glycosyltransferase 8 domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050748">
        <property type="entry name" value="Glycosyltrans_8_dom-fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13778">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 8 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13778:SF3">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 8 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005004090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="372" mass="42284" checksum="D2975BFBED8821A6" modified="2022-01-19" version="1">MTMRRVNIAILVLAVIIFLLVLHHNLLGLSDILRSEITDSNPLGLQPIDFIPAAPQRLEDERNDQEISVVIAASDERLGGAIAAMNSIYRNTKSNVVFYIVTLNDTVDHLRLWLRNTALKNLRYQIVHFDPRVLEGKVEVDAQKAGSIKPLTFARFYLPNLVPHAEKAIYVDDDVIVQDDILELYNTPLKPGHAAAFSDDCDSTTNKVAVRGAGNQYNYIGFLDYKKETIRKLAMKANTCSFNPGVFVANLTEWKLQNITKQLEKWMTLNVVEELYSRTLAGSITTPPLLIVFYKQHSSIDPLWNVRHLGSNAGRRYSPQFVKAAKLLHWNGHFKPWGRTASYAEVWEKWFVPDPTGKFSLIRRHPEAYEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SVG0</accession>
    <name>A0A8C2SVG0_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Protein phosphatase 1 regulatory subunit 13B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">PPP1R13B</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ASPP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015721023.1">
        <property type="nucleotide sequence ID" value="XM_015865537.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SVG0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005004934.1">
        <property type="protein sequence ID" value="ENSCJPP00005002644.1"/>
        <property type="gene ID" value="ENSCJPG00005002964.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107315312"/>
    <dbReference type="CTD" id="23368"/>
    <dbReference type="GeneTree" id="ENSGT00940000153463"/>
    <dbReference type="OrthoDB" id="10038642at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002039">
        <property type="term" value="F:p53 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072332">
        <property type="term" value="P:intrinsic apoptotic signaling pathway by p53 class mediator"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045786">
        <property type="term" value="P:negative regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17224">
        <property type="entry name" value="RA_ASPP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11954">
        <property type="entry name" value="SH3_ASPP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000008">
        <property type="entry name" value="Apoptosis-stimulating of p53 protein 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000030">
        <property type="entry name" value="Apoptosis-stimulating of p53 protein 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047163">
        <property type="entry name" value="ASPP1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028319">
        <property type="entry name" value="ASPP1_RA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048942">
        <property type="entry name" value="ASPP2-like_RA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24131">
        <property type="entry name" value="APOPTOSIS-STIMULATING OF P53 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24131:SF5">
        <property type="entry name" value="APOPTOSIS-STIMULATING OF P53 PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21801">
        <property type="entry name" value="ASPP2-like_RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0728">SH3 domain</keyword>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="977"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="1010"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="15">
        <location>
            <begin position="1076"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="84"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="449"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="509"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="673"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="759"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="815"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="125"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="218"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="269"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="569"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="583"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="692"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="840"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="868"/>
            <end position="904"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005002644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1147" mass="127011" checksum="E8BDB3B453825801" modified="2022-01-19" version="1">MMPMILTVFLSNNEQILTEVPITPETTCRDVVEFCKEPGEGSCHLAEVWRGNERPIPFDHMMYDHLQKWGPRREEVKFFLRHEESPAESNEQGGRQTQNQRNGISIPVEKRAENGVGNPRVELTLSELQDMAARQQQQIENQQQMLVAKEQRLRYLKQQERRQQQSVSESEKLQKLKERVETQETKLKKIRAMRGQVDYSKIMNGNLSTEIEHISAMFQEKQQELQAAVLKVDQLTQQLEDLRKGKLNGFQSYNGQVTGPAAVELKKLYQELQIRNRLNQEQNSKLQQQKELLNKRNMEVAMMDKRINELRERLYKKKVEARQKENIPLNRINGTSSPQSSLSASGRVAAVGPYIQVPSAGTYAVPVDPVKPQSLTIASSSTHGRSKSVETDWGCVKKSPDTWKVSDLDTIADPILSPPTSLQSAVHNVIRLAPTVYDTQHSNDGNWPLLKQSSAPVVKPPQISNTDWKESSMDTALKQGTISSQPLPTSALGSTDKLGLDLGKVPPAIPGVSKQLPQNYGTYPSPVPLGTGSTNSLERRKDGSLPRPGTSIANRQRPVPLPPPSNVHQPSSSQQIQQRISVPPSPTYQPSGPPLFPGGDGRPELPLTVAIRPFLADKGSRPQSPRKGPQTVNSSSIYSMYLQQATPPKNYQQAVYNTLNKSVKAVYGKPVLQSGSTSPSPLPFLHGSLPAQTSPQPQSQPQTDVPEKDQELENAPPPSENSNVENIPRPLSPTKLTPIVHSPLRYQSDADLEALRRKLANAPRPLKKRSSITEPEGPSGPNIQKLLYQRFNTLAGGIESAPFYQPSNPQDFIGILADVDNGNTSTNGNIEEPISVQPTVPLPDEPPPSSDANDNELPSPATEELISTETTNQTSETTEDNNNNLAIVPSTEESSSPTPEVSSPAEEEAPVQPALPPPLPPTKRTNLKKPNSERTGHGLRVKFNPLALLLDASLEGEFDLVQRIIYEVDDPSKPNDEGITPLHNAVCAGHHHIVKFLLDFGVNVNAADSDGWTPLHCAASCNSVHLCKLLVESGAAIFASTISDMQTAADKCEEMEDGYIQCSQFLYGVQEKLGVMNKGVVYALWDYEAQNNDELSFHEGDAITILRRKDDNETEWWWARLNDKEGYVPKNLLGLYPRIKPRQRTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SVG8</accession>
    <name>A0A8C2SVG8_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Embryonic ectoderm development</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">EED</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat ESC family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015707885.1">
        <property type="nucleotide sequence ID" value="XM_015852399.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SVG8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005007406.1">
        <property type="protein sequence ID" value="ENSCJPP00005004424.1"/>
        <property type="gene ID" value="ENSCJPG00005004385.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107308484"/>
    <dbReference type="KEGG" id="cjo:107308484"/>
    <dbReference type="CTD" id="8726"/>
    <dbReference type="GeneTree" id="ENSGT00510000047334"/>
    <dbReference type="OrthoDB" id="7318948at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005677">
        <property type="term" value="C:chromatin silencing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035098">
        <property type="term" value="C:ESC/E(Z) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045120">
        <property type="term" value="C:pronucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001739">
        <property type="term" value="C:sex chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001222">
        <property type="term" value="F:transcription corepressor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990830">
        <property type="term" value="P:cellular response to leukemia inhibitory factor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140718">
        <property type="term" value="P:facultative heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071514">
        <property type="term" value="P:genomic imprinting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048709">
        <property type="term" value="P:oligodendrocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000011">
        <property type="term" value="P:regulation of adaxial/abaxial pattern formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000056">
        <property type="entry name" value="Polycomb protein eed"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051243">
        <property type="entry name" value="PcG_WD-repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10253">
        <property type="entry name" value="POLYCOMB PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="189"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="235"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="48"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005004424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="444" mass="50324" checksum="1F944A16830998F9" modified="2022-01-19" version="1">MSERGETPAAAAASTGEMPAKKQKLSSDENSNPGDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHGQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMINAIKESYEYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEIEDPHKAKCTTLTHPKCVAAIRQTSFSRDSSILIAVCDDASIWRWDRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SW27</accession>
    <name>A0A8C2SW27_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Fibroblast growth factor receptor</fullName>
            <ecNumber evidence="20">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="29" type="primary">FGFR3</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="29" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="29" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="20">Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="20"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2SW27"/>
    <dbReference type="Ensembl" id="ENSCJPT00005007752.1">
        <property type="protein sequence ID" value="ENSCJPP00005004679.1"/>
        <property type="gene ID" value="ENSCJPG00005001291.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159880"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="match status" value="3"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="11 20 22" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15 23" id="KW-1015">Disulfide bond</keyword>
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    <keyword evidence="18" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="10 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 20 26" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 20 24" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
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    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4 20" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="360"/>
            <end position="384"/>
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            <begin position="23"/>
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            <begin position="240"/>
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            <begin position="460"/>
            <end position="748"/>
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    <feature type="region of interest" description="Disordered" evidence="25">
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            <begin position="114"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="25">
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            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="21">
        <location>
            <position position="605"/>
        </location>
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        <location>
            <begin position="466"/>
            <end position="472"/>
        </location>
        <ligand>
            <name>ATP</name>
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            <position position="496"/>
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            <begin position="262"/>
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        </location>
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        </source>
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    <evidence type="ECO:0000256" key="25">
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="799" mass="89526" checksum="1CC50DFE7DE1434A" modified="2022-01-19" version="1">SNQSFVFLGFCIPMFVGCSRETPLIRSLFHSLGSETAFLEELVFGSGDTIELSCDTQSSSVSVFWFKDGIGIAPSNRTHIGQKLLKIINVSYDDSGLYSCKPRHSNEVLGNFTVRVTDSPSSGDDEDDDDESEDTGVPFWTRPDKMEKKLLAVPAANTVRFRCPAGGNPTPTIYWLKNGKEFKGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKYGNIRHTYQLDVLERSPHRPILQAGLPANQTVVVGSNVEFVCKVYSDAQPHIQWLKHMEVNGSKYGPDGTPYVTVLKSWISKNAEADANLNLFNVTEQDEGEYLCRANNFVGIAEKPFWLHIRKPKPAEELMEMDDSGSVYAGILSYGTGLVLFILVLVIVIICRMKMPNKKAMNTTTVQKVSKFPLKRQVSLESNSSMNSNTPLVRITRLSSSDGPMLANVSELELPPDPKWELARSRLTLGKPLGEGCFGQVVMAEAIGIDKDKPNKAITVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVLVEYASKGNLREYLRARRPPGMDYSFDTCKLPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLERRVPFNSCDCMSCRYMIMRECWHAIPSQRPTFTQLVEDLDRVLIMTSTDEYLDLSVPFEQYSPAGQDTHSTCSSGDDSVFAHDLLPDEPCLPKHAPCNGVIRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SY97</accession>
    <name>A0A8C2SY97_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">DOP1 leucine zipper like protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">DOP1A</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DOP1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015714466.1">
        <property type="nucleotide sequence ID" value="XM_015858980.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005007273.1">
        <property type="protein sequence ID" value="ENSCJPP00005004335.1"/>
        <property type="gene ID" value="ENSCJPG00005004309.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107311993"/>
    <dbReference type="CTD" id="23033"/>
    <dbReference type="GeneTree" id="ENSGT00390000016421"/>
    <dbReference type="OrthoDB" id="297643at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040314">
        <property type="entry name" value="DOP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056457">
        <property type="entry name" value="DOP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007249">
        <property type="entry name" value="DOP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056459">
        <property type="entry name" value="TPR_DOP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056458">
        <property type="entry name" value="TPR_DOP1_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14042">
        <property type="entry name" value="DOPEY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14042:SF22">
        <property type="entry name" value="PROTEIN DOPEY-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24598">
        <property type="entry name" value="DOP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04118">
        <property type="entry name" value="Dopey_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24601">
        <property type="entry name" value="TPR_DOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24597">
        <property type="entry name" value="TPR_DOP1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DOP1 N-terminal" evidence="8">
        <location>
            <begin position="11"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="DOP1-like middle TPR" evidence="9">
        <location>
            <begin position="319"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="DOP1-like TPR" evidence="11">
        <location>
            <begin position="1359"/>
            <end position="1733"/>
        </location>
    </feature>
    <feature type="domain" description="DOP1-like C-terminal" evidence="10">
        <location>
            <begin position="1900"/>
            <end position="2420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="549"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="695"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1183"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1248"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="711"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1197"/>
            <end position="1216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00046326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF24598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF24601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005004335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="2481" mass="279231" checksum="B7D1788A4F82A0F2" modified="2022-01-19" version="1">MNTEELELLTDSKYRNYVAAVDKALKNFEYSSEWADLISALGKLNKVLQNNAKYQVVPKKLTIGKRLAQCLHPALPGGVHRKALETYEIIFKIIGPKRLAKDLFLYSSGLFPLLANAAMSVKPTLLSLYEIYYLPLGKTLKPGLQGLLTGILPGLEEGSEYYERTNTLLEKVASAVDQSAFYSALWGSLLTSPAVRLPGITYVLSHLNRKLSMEDQLYIIGSDIELMVEAVSTSVQDTSVLVQRSTLDLILFCFPFHMSQATRPDMIRILSAALHVVLRRDMSLNRRLYAWLLGFDNNGALVGPRSTRHSNPEEHATYYFNTFSKEMLVQAMTGILQVNGNGEESTLMQDLKPFRILISLLDKPELGPAILEDVLIEVFRTLYTQCKTELELQAEPSFNKDHTQLSSKLRENKKTAELIKTANLLFNSFEPYYMWDYIARWFEECCRRTLHARLQTGPAGGNEQSELPLTNFCLLVDFLLDIVSLETYIEIQTEHLPQLLLRMISALTSHLHTLHLSELTDSLRLCSKILSKVQPPLLSAGVDGTLQLPSGHSSSIKEWENKKVPSVSLENPNDVFEDGENPPSSRSSESGFTEFVQYQADTTDDIDRALNEGHGAPGIPIIGSTSSETETASTVGSEETVVQPPSIVTQGTATRSGKTIQKTAMQCCLEYVQQFLTRFINLYIIQSNSLSQPLGTELPADPAREQGQTTKWDREQGDAKVKKMNKKNSPKEYLPAFIAACQLYLECSSFPVYIAEGNRTSELHPGKPEVDCEQVQPPLWLQTLMNACKQARDFSIQGVTISLVMDLVGLTQSVALVTGENLNNVETAQPLSPNQGRVAVVIRPPLTQGNLRYMAEKTDFFKHIALTLWDQLGDGTPQHHQKSVELFYQLHNLVPSSSICEDVISQQLTHRDKKVRMEAHAKFAVLWHLTRDLHINKSSSFGRTFDRSLFIMLDSLNSLDGSTWSVGQAWLNQVLQRHDIARVLEPLLLLLLHPKTQRVSVQRVQAECYWTKSPCHPEEENEKHFMQKFSCADAFTHVPVSQGQLIIPKEGNEKQLAMDEMENFSLTVNPLSDRLSLLSTSSETIPMVVSDFDLPDNQVEILQSSDSGCSQSSTGDNISYEVETESLSAQDSSQTLREDSPDEIVQQVVTDLICKVVSSLGEENEPIKYSLCSEDTSCKFNPLDNPEEVTKSEEQNIESSQSSLLSNDSSQLLSASTETGLESLRDEISRNNSSPCITASQQSLSDLTLTSTESKSRKRSHSSIQFTFKGKLPEKMSEKETIVKEAGKQPGAKPKVKIAKKKDEEKKKAQTEKLKQTNVFFSDGLDLENWYSCGEGEISEIESDVGSPGMRKSPNFNIHPLYQHVLLYLQLYDSSRTLYAFSAIKAILKTNPSAFVSAISTTSVNNAYTPQLSLLQNLLARHRISVMGKDFYSHIPVDSNHNFRSSMYIEILISLCLYYMRSHYPTHVKVTSQDLIGNRNMQMMSIEILTLLFAELAKVIESSAKGFPSFISDMLSKCKVQKVILHCLLSSIFSAQKWHSEKMAGKNIVAVEEGFSEDSLINFSEDEFDNGSTLQSQLLKVLQRLIVLEHKVMTVPEENETGFDFVITDLEHIGPQQPMTSLQYLHSQPITCQGMFLCAVIRALHQHCACKMHPQWIGLITSTLPYMGKVLQRVVVSVTLQLCRNLDNLIQQYKYETGLSDNRPIWMASVTPPDMVLTLLEGITTIIHYCLLDPSTQYHQLLVNVDQKHLIEARNGILSILHMIMSSVTLLWNILHLADSSEKTAAAAAASVTTINLGSTKNLRQQILELLGPISMNHGVYFMAAIAFVWNERRQNKNASRTKVIPTAGEEQLLLVELVRSISVMRTETVIQTVKEVLKQPPAIAKDKKHLSLEVCMLQFFYAYTQRIPVTSLVDSWAALLLLLKDSIQVGLPAPGQFLILGVLNEFIMKNPSLENKKDQRDLQDVTHKIVDAIGAIAGSSLEQTTWLRRNLEVKPSPKIMVDGNNLESDVEDMLSPAMETSSITPSVYSVHALTLLSEVLAHLLDMVFYSDEKERVIPLLVNIMHYVVPYLRNHSAHNASSYRACVQLLSSLSGYQYTRRAWKKEAFDLFMDSNFFQMDASCVNYWRAIMDNLMTHDKTTFRDLMTRVAVAQSSSLNLFANREAELEQRAMLLKRLAFAIFSSEIDQYQKYLPDIQERLVESLRLPQVPTLHSQVFLFFRVLLLRMSPQHLTSLWPTMITELVQVFLLMEQELTADEDISRTSGPSVAGLETTYTGGNGFSTSYNSQRWLNLYLSACKFLDLALALPSENLPQFQMYRWAFIPEASDDSGLEVRRQGTHQREFKPYVVRLAKLLRKKAKDKQEDFKTMVLEGLEMAKHQKNPEENSSGKTLSWEPGHLLLTIYTVRSIEQLLPFFNVLSQVFNSKVTSRCAGHSGSPVLYPNCFPSKDIKMENLKTFSSKARQKIEEMVEKDFLEGVIKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SYS3</accession>
    <name>A0A8C2SYS3_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BLOC-1 related complex subunit 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BORCS6</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SYS3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005006887.1">
        <property type="protein sequence ID" value="ENSCJPP00005004012.1"/>
        <property type="gene ID" value="ENSCJPG00005004081.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00490000043453"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099078">
        <property type="term" value="C:BORC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032418">
        <property type="term" value="P:lysosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019314">
        <property type="entry name" value="BORCS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046465">
        <property type="entry name" value="BORCS6_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13440">
        <property type="entry name" value="BLOC-1 RELATED COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13440:SF7">
        <property type="entry name" value="BLOC-1 RELATED COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10157">
        <property type="entry name" value="BORCS6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BLOC-1-related complex subunit 6 C-terminal helix" evidence="2">
        <location>
            <begin position="243"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005004012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="346" mass="36076" checksum="0D61B6B8EFCBE195" modified="2022-01-19" version="1">RLPRVFTTGPSLSAPSDPSQSGAGWKGPQRSSSPTPGVRALCSRAALLPLAPQGASPPAPPAMWRCAPRTSRLRAQGQLARCQQAKSGCCWAQRRPPIGGGKQPIAGRDSTRPPPPFSPHTTNVTETQFPRAYPAGPVMAARPSAAAGPPGDDGASRDQRSLEALSLAAAGGAVSGRSLPDGRQLPEGRRATLASALELEGTVLREGRLTQFVANNLERRIRLSGVPRAEQHSAAAGGAGSIPAIDPGALQDVVALAGQVAAQVDELLRNVHCGLQALTALSVGCIQTYRDGVESLGEAADLSIRAMYALVARCEELDRAMQPVPALAKRIRDMKGTLERLEGLCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SZJ0</accession>
    <name>A0A8C2SZJ0_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the potassium channel KCNE family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SZJ0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005009757.1">
        <property type="protein sequence ID" value="ENSCJPP00005006158.1"/>
        <property type="gene ID" value="ENSCJPG00005005774.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000235098"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005251">
        <property type="term" value="F:delayed rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015459">
        <property type="term" value="F:potassium channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044325">
        <property type="term" value="F:transmembrane transporter binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902282">
        <property type="term" value="F:voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097623">
        <property type="term" value="P:potassium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0086091">
        <property type="term" value="P:regulation of heart rate by cardiac conduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060307">
        <property type="term" value="P:regulation of ventricular cardiac muscle cell membrane repolarization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000369">
        <property type="entry name" value="K_chnl_KCNE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15282:SF10">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY E MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15282">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY E MEMBER 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02060">
        <property type="entry name" value="ISK_Channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="108" mass="12822" checksum="0186008EBC7C9B93" modified="2022-01-19" version="1">TLMPSIKRTWKEAVPPPSLASLISQCVLRLLERNLDTKKNATEQKEPQYKPYDNAYFFILFVMLFYSFLALTVFFGYVRSKKAISKKDPYQEFIEDRNQKKWNDSMIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SZL3</accession>
    <name>A0A8C2SZL3_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Tyrosine-protein kinase</fullName>
            <ecNumber evidence="19">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">HCK</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15 19">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the protein kinase superfamily. Tyr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="19"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2SZL3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005009782.1">
        <property type="protein sequence ID" value="ENSCJPP00005006175.1"/>
        <property type="gene ID" value="ENSCJPG00005005344.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158738"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005901">
        <property type="term" value="C:caveola"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001784">
        <property type="term" value="F:phosphotyrosine residue binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050830">
        <property type="term" value="P:defense response to Gram-positive bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006909">
        <property type="term" value="P:phagocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032956">
        <property type="term" value="P:regulation of actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050764">
        <property type="term" value="P:regulation of phagocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071801">
        <property type="term" value="P:regulation of podosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd05073">
        <property type="entry name" value="PTKc_Hck"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000553">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000036">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000010">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0519">Myristate</keyword>
    <keyword evidence="8 18 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="3 17" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="6 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="13 19" id="KW-0829">Tyrosine-protein kinase</keyword>
    <keyword evidence="11" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="SH3" evidence="22">
        <location>
            <begin position="63"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="21">
        <location>
            <begin position="129"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="23">
        <location>
            <begin position="247"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="27"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU362096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="512" mass="57952" checksum="CEC6CB51A8E2D3F0" modified="2022-01-19" version="1">WGFWCCCNGPTSPPLTHTHRMGCVKSKEDSVQEKMQLGHEKKDPTSGSKDPGKHPGANLTAGSGDTVVLALYDYEAMHSGDLSFQKGERLQVLEQSGEWWRARSLVTGLKGFIPSNFVARANSLEAEEWFFKDISRKDAERQLLGPGNTLGSFMIRDSETTKGCYSLSVRDGDSLQGGSIKHYRIRTLDSGGFYISSRSSFDTLQELVEHYKGQSDGLCQRLTYPCSVPKPQKPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVSAFLEEANLMKGLQHDKLVRLHAVVTREEPIYIITEFMEKGSLLDFLKSEEGNKQTLPKLIDFSAQVAEGMAFIEKRNYIHRDLRAANILVSEILVCKIADFGLARIIEDNEYVAREGAKFPIKWTAPEAINYGSFTIKSDVWSFGILLTEIVTYGRIPYPGMSSAEVIRALEHGYRMPRTENCPEELYDVMMRCWKTRPEDRPTFEYMQSILEDFFTATEGQYQKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SZY5</accession>
    <name>A0A8C2SZY5_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Transmembrane emp24 domain-containing protein 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">p24 family protein gamma-3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">p27</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="primary">TMED7</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Appears to play a role in the biosynthesis of secreted cargo including processing and post-translational modifications.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Cytoplasmic vesicle</location>
            <location evidence="16">COPI-coated vesicle membrane</location>
            <topology evidence="16">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Cytoplasmic vesicle</location>
            <location evidence="17">COPII-coated vesicle membrane</location>
            <topology evidence="17">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
            <location evidence="3">cis-Golgi network membrane</location>
            <topology evidence="3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="21">Membrane</location>
            <topology evidence="21">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 21">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015705475.1">
        <property type="nucleotide sequence ID" value="XM_015849989.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SZY5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005010016.1">
        <property type="protein sequence ID" value="ENSCJPP00005006338.1"/>
        <property type="gene ID" value="ENSCJPG00005005955.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107306668"/>
    <dbReference type="KEGG" id="cjo:107306668"/>
    <dbReference type="CTD" id="51014"/>
    <dbReference type="GeneTree" id="ENSGT00940000158463"/>
    <dbReference type="OrthoDB" id="62956at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome Z"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030663">
        <property type="term" value="C:COPI-coated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033116">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.680:FF:000013">
        <property type="entry name" value="Transmembrane emp24 domain containing 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.680">
        <property type="entry name" value="GOLD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 23" id="KW-0732">Signal</keyword>
    <keyword evidence="6 21 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034182978" description="Transmembrane emp24 domain-containing protein 7" evidence="23">
        <location>
            <begin position="29"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="24">
        <location>
            <begin position="40"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00059266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00060424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00060446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00068790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00075157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00080822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="218" mass="24620" checksum="2E7F54547A95FCF0" modified="2022-01-19" version="1">MLPRVCGADLPLGRLLVVVLALACATRASEITFELPDNAKQCFYEEIAQGTKCTLEFQVITGGHYDVDCRLEDPDGIVLYKEMKKQYDSFTFTASRNGTYKFCFSNEFSTFTHKTVYFDFQVGEDPPLFPSENRVTALTQMESACVSIHEALKSVIDYQTHFRLREAQGRSRAEDLNTRVAYWSIGEAIILLVVSIGQVFLLKSFFSDKRTTTTRVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T0E5</accession>
    <name>A0A8C2T0E5_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Fli-1 proto-onco, ETS transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">FLI1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ETS family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015739598.1">
        <property type="nucleotide sequence ID" value="XM_015884112.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T0E5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005010276.1">
        <property type="protein sequence ID" value="ENSCJPP00005006518.1"/>
        <property type="gene ID" value="ENSCJPG00005006095.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107324254"/>
    <dbReference type="CTD" id="2313"/>
    <dbReference type="GeneTree" id="ENSGT00940000158261"/>
    <dbReference type="OrthoDB" id="10067219at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008015">
        <property type="term" value="P:blood circulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035855">
        <property type="term" value="P:megakaryocyte development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd08541">
        <property type="entry name" value="SAM_PNT-FLI-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000010">
        <property type="entry name" value="Fli-1 proto-oncogene, ETS transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000039">
        <property type="entry name" value="Friend leukemia integration 1 transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000418">
        <property type="entry name" value="Ets_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046328">
        <property type="entry name" value="ETS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003118">
        <property type="entry name" value="Pointed_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035573">
        <property type="entry name" value="SAM_PNT-FLI-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849:SF161">
        <property type="entry name" value="FRIEND LEUKEMIA INTEGRATION 1 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00178">
        <property type="entry name" value="Ets"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02198">
        <property type="entry name" value="SAM_PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00454">
        <property type="entry name" value="ETSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00413">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00251">
        <property type="entry name" value="SAM_PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00345">
        <property type="entry name" value="ETS_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00346">
        <property type="entry name" value="ETS_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50061">
        <property type="entry name" value="ETS_DOMAIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51433">
        <property type="entry name" value="PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="PNT" evidence="10">
        <location>
            <begin position="112"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="ETS" evidence="9">
        <location>
            <begin position="261"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="211"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="225"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="432" mass="48761" checksum="B32596A68CB104EB" modified="2022-01-19" version="1">MDGTIKEALSVVSDDQSLFDSTYGAATHLPKADMTASGNPDYGQPHKINPLPPQQEWINQPVRVNVKREYDHMNGSRESPVDCSVNKCSKLVGAGTESNPMSYSTYMDEKNGPPPNMTTNERRVIVPADPTLWTQEHVRQWLEWAIKEYGLMEIDTTFFQNMDGKELCKMNKDDFLRTTSLYNTEVLLSHLSYLRESSSLLAYNTPSHTEASSRLATKEGPPVAGTQNVNKTTEQQRPQPDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNASCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPTESSMYKYPSDLSYMPSYHAHQQKVNFVPPHPSSMPVTSSSFFGAASPYWTSPAGSIYPNPNVPRHPNAHVSPHLGSYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T1L4</accession>
    <name>A0A8C2T1L4_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <ecNumber evidence="5">4.2.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">40S ribosomal protein S3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">RPS3</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2T1L4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005009858.1">
        <property type="protein sequence ID" value="ENSCJPP00005006232.1"/>
        <property type="gene ID" value="ENSCJPG00005005857.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000008610"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071159">
        <property type="term" value="C:NF-kappaB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032587">
        <property type="term" value="C:ruffle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140297">
        <property type="term" value="F:DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032357">
        <property type="term" value="F:oxidized purine DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032358">
        <property type="term" value="F:oxidized pyrimidine DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051018">
        <property type="term" value="F:protein kinase A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097100">
        <property type="term" value="F:supercoiled DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044390">
        <property type="term" value="F:ubiquitin-like protein conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070301">
        <property type="term" value="P:cellular response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071356">
        <property type="term" value="P:cellular response to tumor necrosis factor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045738">
        <property type="term" value="P:negative regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031397">
        <property type="term" value="P:negative regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042104">
        <property type="term" value="P:positive regulation of activated T cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905053">
        <property type="term" value="P:positive regulation of base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032743">
        <property type="term" value="P:positive regulation of interleukin-2 production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902231">
        <property type="term" value="P:positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031116">
        <property type="term" value="P:positive regulation of microtubule polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901224">
        <property type="term" value="P:positive regulation of non-canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050862">
        <property type="term" value="P:positive regulation of T cell receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061481">
        <property type="term" value="P:response to TNF agonist"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02413">
        <property type="entry name" value="KH-II_40S_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1140.32:FF:000005">
        <property type="entry name" value="40S ribosomal protein S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.20:FF:000006">
        <property type="entry name" value="40S ribosomal protein S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="entry name" value="Ribosomal protein S3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057258">
        <property type="entry name" value="Ribosomal_uS3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_uS3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018280">
        <property type="entry name" value="Ribosomal_uS3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005703">
        <property type="entry name" value="Ribosomal_uS3_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003219">
        <property type="entry name" value="PRK04191.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01008">
        <property type="entry name" value="uS3_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760:SF32">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="Prokaryotic type KH domain (KH-domain type II)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="Ribosomal protein S3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00548">
        <property type="entry name" value="RIBOSOMAL_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 17" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="10 17" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="9 16" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="KH type-2" evidence="19">
        <location>
            <begin position="20"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="213"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="18">
        <location>
            <begin position="233"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00035408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="242" mass="26448" checksum="E8542CC0A48DE5CF" modified="2022-01-19" version="1">GAVQTAQRSFVADGIFKAELNEFLTRELAEDGYSGVEVRVTPTRTEIIILATRTQNVLGEKGRRIRELTAVVQKRFGFPEGSVELYAEKVATRGLCAIAQAESLRYKLLGGLAVRRACYGVLRFIMESGAKGCEVVVSGKLRGQRAKSMKFVDGLMIHSGDPVNYYVDTAVRHVLLRQGVLGIKVKIMLPWDPSGKIGPKKPLPDHVSIVEPKEEILPTTPISEQKGGKPEQPAMPQPVPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T327</accession>
    <name>A0A8C2T327_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Y-box binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">YBX1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015737879.1">
        <property type="nucleotide sequence ID" value="XM_015882393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T327"/>
    <dbReference type="SMR" id="A0A8C2T327"/>
    <dbReference type="Ensembl" id="ENSCJPT00005011953.1">
        <property type="protein sequence ID" value="ENSCJPP00005007794.1"/>
        <property type="gene ID" value="ENSCJPG00005007085.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107323390"/>
    <dbReference type="KEGG" id="cjo:107323390"/>
    <dbReference type="CTD" id="4904"/>
    <dbReference type="GeneTree" id="ENSGT00940000153341"/>
    <dbReference type="OrthoDB" id="203339at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070937">
        <property type="term" value="C:CRD-mediated mRNA stability complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070062">
        <property type="term" value="C:extracellular exosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071204">
        <property type="term" value="C:histone pre-mRNA 3'end processing complex"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005689">
        <property type="term" value="C:U12-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062153">
        <property type="term" value="F:C5-methylcytidine-containing RNA reader activity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051020">
        <property type="term" value="F:GTPase binding"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0035198">
        <property type="term" value="F:miRNA binding"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098761">
        <property type="term" value="P:cellular response to interleukin-7"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008544">
        <property type="term" value="P:epidermis development"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:miRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000773">
        <property type="term" value="P:negative regulation of cellular senescence"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900152">
        <property type="term" value="P:negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051154">
        <property type="term" value="P:negative regulation of striated muscle cell differentiation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000767">
        <property type="term" value="P:positive regulation of cytoplasmic translation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903608">
        <property type="term" value="P:protein localization to cytoplasmic stress granule"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051031">
        <property type="term" value="P:tRNA transport"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000054">
        <property type="entry name" value="Nuclease-sensitive element-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050181">
        <property type="entry name" value="Cold_shock_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11544">
        <property type="entry name" value="COLD SHOCK DOMAIN CONTAINING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="2">
        <location>
            <begin position="56"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="192"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005007794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="326" mass="36349" checksum="3BA8F4D26BF5C1D0" modified="2022-01-19" version="1">MSSEAETQPPAAPVPAAAPAANNAESKPNGGSGNGSGGLGSAAPPAGGDKKVIATKVLGTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKKNNPRKYLRSVGDGETVEFDVVEGEKGAEAANVTGPGGVPVQGSKYAADRNHYRRYPRRRGPPRNYQQNYQNSESGEKNEGAENIPEGQAQQRRPYRRRRYPPYYMRRPYGRRPQYSNPPVQGEIVEGADNQGAGEQGRPVRQNMYRGYRPRFRSLTFRGPPRQRQPREDGNEEDKENQGDETQGQQPPQRRYRRNFNYRRRRPENPKPQDGKETKTAEPPAENTSAPEAEQGGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T387</accession>
    <name>A0A8C2T387_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mab-21-like HhH/H2TH-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ITPRIP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T387"/>
    <dbReference type="Ensembl" id="ENSCJPT00005010687.1">
        <property type="protein sequence ID" value="ENSCJPP00005006867.1"/>
        <property type="gene ID" value="ENSCJPG00005006335.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000235253"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026250">
        <property type="entry name" value="ITPRIP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046906">
        <property type="entry name" value="Mab-21_HhH/H2TH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024810">
        <property type="entry name" value="MAB21L/cGLR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10656">
        <property type="entry name" value="CELL FATE DETERMINING PROTEIN MAB21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10656:SF40">
        <property type="entry name" value="INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR-INTERACTING PROTEIN-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20266">
        <property type="entry name" value="Mab-21_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02107">
        <property type="entry name" value="INOS145TPRIP"/>
    </dbReference>
    <dbReference type="SMART" id="SM01265">
        <property type="entry name" value="Mab-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="428"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Mab-21-like HhH/H2TH-like" evidence="9">
        <location>
            <begin position="438"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="56"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="140"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="108"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="554" mass="64309" checksum="A6286372B6035A37" modified="2022-01-19" version="1">MIPPQHEIEQRNEQQSWVDMSSLLFALLQYWKIWFSMGLILLLFWNMVQSLKMKKRDESSSENDSSSGKEEASGVKEEEEEEVEKEEQEEHQEEQVEQVEQVGQQEQVEQEEQVEQEVQVEQEDQQEHVELVEQQVQVEQGEQQEQVEQVEMEEQEEEEDDEEEDFKDSALTKFLKQRALAKVEGRATRCPIVEELMNELLQTFRLLWSNSFFPVLQPAIGVGSAFEGWSPREWDTVYCLLVPIEAPPGHSFFLELGDEGHGLARNSRVRVELQCMCQREKLLGNVLCFLHHEEEELSQNQDPSLLQTLCTDSYLDVERTVTWFTVQVAAIWKTTHHAHAYSLKVLPSRRSCKLQLTEAYSGEKVLVELLFGVQQEYSDIYLTSQNTDAGFTPSTTWPQSCAVAEKKFFQHTARSTGQDSSHLHCLTLLASILVGMGFSTYVIKTLVLHSLAIIPLKKWRRKYFLNRMENLLRYLRFCLDEKCLNHFFLGSKSVHSTIVLPQSFRSAKPLNLFQHLEEDPDAHSIALREFRELKDQQLPSYPHQPLYPSSNHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T7E1</accession>
    <name>A0A8C2T7E1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 16">Dolichol-phosphate mannosyltransferase subunit 1</fullName>
            <ecNumber evidence="8 16">2.4.1.83</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">DPM1</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins; catalytic subunit of the dolichol-phosphate mannose (DPM) synthase complex.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a di-trans,poly-cis-dolichyl phosphate + GDP-alpha-D-mannose = a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + GDP</text>
            <dbReference type="Rhea" id="RHEA:21184"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6 16">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of the dolichol-phosphate mannose (DPM) synthase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 16">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 16">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.83" evidence="8 16"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2T7E1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005012353.1">
        <property type="protein sequence ID" value="ENSCJPP00005008083.1"/>
        <property type="gene ID" value="ENSCJPG00005007297.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153481"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033185">
        <property type="term" value="C:dolichol-phosphate-mannose synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004582">
        <property type="term" value="F:dolichyl-phosphate beta-D-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180047">
        <property type="term" value="P:dolichol phosphate mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070482">
        <property type="term" value="P:response to oxygen levels"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd06442">
        <property type="entry name" value="DPM1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000036">
        <property type="entry name" value="Dolichol-phosphate mannosyltransferase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039528">
        <property type="entry name" value="DPM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398:SF1">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 16" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 16" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0464">Manganese</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="17">
        <location>
            <begin position="10"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00002636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00014858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU365083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005008083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="242" mass="27170" checksum="F3DE6E157D3F4FEA" modified="2022-01-19" version="1">MAARRGDKVSVLLPTYNERDNLPLVVWLLERTLRSSGTDFEIIVIDDGSPDGTQQVAEQLQRLYGADTILLRPRPKKLGLGTAYIHGMKHATGNFIVIMDADLSHHPKFIPEFIRKQKEGNFDIVSGTRYKGNGGVYGWDLKRKLISRGANFLTQVLLRPGASDLTGSFRLYRKEVLQKLMEKCVSKGYVFQMEMIVRARQLGYTIGEVPISFVDRVYGESKLGGNEIVSFLKGLLTLFATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T808</accession>
    <name>A0A8C2T808_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dynein light chain Tctex-type 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">DYNLT1</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein light chain Tctex-type family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015713828.1">
        <property type="nucleotide sequence ID" value="XM_015858342.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T808"/>
    <dbReference type="Ensembl" id="ENSCJPT00005014651.1">
        <property type="protein sequence ID" value="ENSCJPP00005009847.1"/>
        <property type="gene ID" value="ENSCJPG00005008617.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107311643"/>
    <dbReference type="KEGG" id="cjo:107311643"/>
    <dbReference type="CTD" id="6993"/>
    <dbReference type="GeneTree" id="ENSGT00940000154531"/>
    <dbReference type="OrthoDB" id="10059120at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043657">
        <property type="term" value="C:host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099503">
        <property type="term" value="C:secretory vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019060">
        <property type="term" value="P:intracellular transport of viral protein in host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21462">
        <property type="entry name" value="DLC-like_DYNLT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1140.40:FF:000001">
        <property type="entry name" value="Dynein light chain Tctex-type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.40">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005334">
        <property type="entry name" value="Tctex-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038586">
        <property type="entry name" value="Tctex-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255:SF19">
        <property type="entry name" value="DYNEIN LIGHT CHAIN TCTEX-TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255">
        <property type="entry name" value="T-COMPLEX-ASSOCIATED-TESTIS-EXPRESSED 1/ DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03645">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00072460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005009847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="113" mass="12422" checksum="33515272D5B92F3D" modified="2022-01-19" version="1">MDEFQAGEETSFVVDEVSNIIKEAIESAIGGNAYQHSKVNQWTTSVVEQSLSQLTKLGKPFKYIVTCVIMQKNGAGLHTASSCFWDNSSDGTCTVRWENKTMYCIVSAFGLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T8A5</accession>
    <name>A0A8C2T8A5_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">C10H15orf39</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T8A5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005012781.1">
        <property type="protein sequence ID" value="ENSCJPP00005008431.1"/>
        <property type="gene ID" value="ENSCJPG00005007524.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000002672"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037656">
        <property type="entry name" value="DUF5525"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000082">
        <property type="entry name" value="SEA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28422">
        <property type="entry name" value="SIMILAR TO HUMAN CHROMOSOME 15 OPEN READING FRAME 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28422:SF1">
        <property type="entry name" value="SIMILAR TO HUMAN CHROMOSOME 15 OPEN READING FRAME 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17663">
        <property type="entry name" value="DUF5525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50024">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="531"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="SEA" evidence="2">
        <location>
            <begin position="868"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="490"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="748"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="810"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="748"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="819"/>
            <end position="828"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005008431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="909" mass="98470" checksum="96175895770CBF61" modified="2022-01-19" version="1">MASKRHSEPLDAVPFHKLPRLEAEPDPGVPSMLCKPNPAPTASPETHLGYNGSYFSCPQTERQLLHCLLLQPHSPMGRPSAEQGKNHPMWDPLVAQDRWSSQQGHPFPLRKPPAIPKPVYAAPLCFSPLSSQGGDTLQRGLGAMSAVPPPSPVTLPHYYTAFEKYHGPPAVHDQGKAPGIPTFIPDPWMKVHWEHPSACYPQPPYPQPAGSFYKAFSFTVNGKSPPFPRTYLKPPDLLRHHPSPSDGFVSRLAAPATLPPLKAMGPPRDPEPPPLHPARYLHPNPGLAFSPVDAALFTEHHSDGRTAPLDAHGRRVVTGHSSAFHPIHTPQKTPVGLLGPFPKGEDGYSLDKAMMANPVPCQQQEVKGGVGEATKGHFTPCGAIFPQERPRDRWSSDVSPPSPPMPVIKMVFSLAPYREYLEGMEGSTDVPNEHPRGVTPPQNTSSCWEPAGIKVTSISLPQVPPSQVESSAAFMFKKYKILKSWGSACAPQPSSPPHTWQGSPSTSVPQEPFHNPKHVDMSPVLPQAPLPTPCHIPAQPCVANQGFSALHMSLCSIISCSVSASSPELLRDWLRRTEPGETLIWLAFRNAATLLSKLLAQLETFTFTCKCPFPYVLRAGAIFIPIHVVKEKLFPELPGASVDQVLQKHKVELRPTTLSEEKLLRELELKSCTSRMLKLLALKQLPDIYPDLLNLLWHHSIQQQLASTEAGESLTSTATTPQPGATKALCQHGAAAGVSWYPKAEDVTQGSPVGLTTQMPSPAAPPEYTLGSVHPPSFKPPAVGPSTSSPSSTYLPASIAISHAPTKPTLLTSAAHPKSSPSLATSQHPFADGDDVPKATSWVVGEAFTTEQLVRTVGNAGSMVTKIPVHTLPLSFRLLGIAFTRDLSKKSSRSYKELEKEVRMMVSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T8B8</accession>
    <name>A0A8C2T8B8_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Zinc finger protein 740</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">ZNF740</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T8B8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005013492.1">
        <property type="protein sequence ID" value="ENSCJPP00005008981.1"/>
        <property type="gene ID" value="ENSCJPG00005007956.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159609"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000460">
        <property type="entry name" value="Putative zinc finger protein 740"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000042">
        <property type="entry name" value="Zinc finger protein 148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000230">
        <property type="entry name" value="Zinc finger protein 148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF57">
        <property type="entry name" value="ZINC FINGER PROTEIN 740"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="122"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="24"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00069113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005008981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="186" mass="21231" checksum="6D8EE426CD345BF3" modified="2022-01-19" version="1">MAQASLLACEGLSGVCLVPTVASKKMMPKQSSKQAEGRERGSSPDVLALRQDGEKSRSRKEEETAEASQPKKSIKKVVVIKQNCSFQLRIHKNFICEQCCGAFRSSYHLKRHILIHTGEKPFGCDQCSMKFIQKYHMERHKRTHSGEKPYQCERCMQSFSRTDRLLRHKRMCQGCQTKGPEAQLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T8N8</accession>
    <name>A0A8C2T8N8_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peroxin-7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">PEX7</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the WD repeat peroxin-7 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015713897.1">
        <property type="nucleotide sequence ID" value="XM_015858411.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T8N8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005015060.1">
        <property type="protein sequence ID" value="ENSCJPP00005010123.1"/>
        <property type="gene ID" value="ENSCJPG00005008865.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107311674"/>
    <dbReference type="KEGG" id="cjo:107311674"/>
    <dbReference type="CTD" id="5191"/>
    <dbReference type="GeneTree" id="ENSGT00940000157264"/>
    <dbReference type="OrthoDB" id="273771at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005053">
        <property type="term" value="F:peroxisome matrix targeting signal-2 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001958">
        <property type="term" value="P:endochondral ossification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008611">
        <property type="term" value="P:ether lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001764">
        <property type="term" value="P:neuron migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006625">
        <property type="term" value="P:protein targeting to peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044536">
        <property type="entry name" value="PEX7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46027">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46027:SF1">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="104"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="148"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="191"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="235"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005010123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="320" mass="35313" checksum="47BACD3CE64ADA15" modified="2022-01-19" version="1">MGTAGGGVLRLPGLHGYAAEFSPYWPGRVACAAAQYYGIAGCGTLAVLEQNETGIVLLRSFDWNDGLFDVTWSENNEHVLITSSGDGSLQIWDIAKPKGPLQVYKEHTQEAYSVDWSQTRGEQLVVSGSWDQTAKLWDPAVGKSLRTFKGHEGVIYSTIWSPHIPGCFASASGDQTLRIWDVKAPGVRLVIPAHQAEILSCDWCKYDENLLVTGAVDCSLKGWDLRNVRQPVFVLLGHTYAVRRVKFSPFHATLLASCSYDFTVRFWDFSKPNPLLETVEHHTEFTCGLDLSLHKCGQVVDCAWDELVKIYTPSCLAAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TA83</accession>
    <name>A0A8C2TA83_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HscB family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TA83"/>
    <dbReference type="Ensembl" id="ENSCJPT00005014481.1">
        <property type="protein sequence ID" value="ENSCJPP00005009726.1"/>
        <property type="gene ID" value="ENSCJPG00005008517.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00960000192087"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051259">
        <property type="term" value="P:protein complex oligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.20">
        <property type="entry name" value="HscB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004640">
        <property type="entry name" value="HscB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040682">
        <property type="entry name" value="HscB_4_cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036386">
        <property type="entry name" value="HscB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009073">
        <property type="entry name" value="HscB_oligo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14021">
        <property type="entry name" value="IRON-SULFUR CLUSTER CO-CHAPERONE PROTEIN HSCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14021:SF15">
        <property type="entry name" value="IRON-SULFUR CLUSTER CO-CHAPERONE PROTEIN HSCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18256">
        <property type="entry name" value="HscB_4_cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07743">
        <property type="entry name" value="HSCB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47144">
        <property type="entry name" value="HSC20 (HSCB), C-terminal oligomerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HscB tetracysteine metal binding motif" evidence="4">
        <location>
            <begin position="36"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="Co-chaperone HscB C-terminal oligomerisation" evidence="3">
        <location>
            <begin position="274"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005009726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="371" mass="41169" checksum="4D63687DF4498C73" modified="2022-01-19" version="1">MQAALRVQLGRARRALRVSELAPRPRCVGPGSVPSPRCWSCGVALSGLDAVPHFCPRCRALQPPEPRPDLFRLMECDRSFRIDTQRLQRRFRSLQRALHPDRFGQSPAVSDRPRVTDRCPMGDALCRLRAPGPLSSGESYGTPEGICSHCLQCSGTPTAPSALTAPSPDHGCVQGHRSVRCLLTHYSLAEGAALLGAALFPHQQGLPDIAAPPEPRPLPGECWDGQIHTPILGPRSRSVLTLREPIFTFPNSCFVFLQLELRGVEPAQETDCDEDKEFLMEIMEINEKLAEPQNDEILGEIETLIKGGPRSAGFVPSEFYIPVLSTETCGVYIEEEPWVQCWRSKQVELLGSEQPLVCVCVCVYIYRYCWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TBK3</accession>
    <name>A0A8C2TBK3_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Cytospin-A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">SPECC1L</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12 13">Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 13">May interact with both microtubules and actin cytoskeleton.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasm</location>
            <location evidence="1 13">Cytoskeleton</location>
            <location evidence="1 13">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
            <location evidence="13">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Cell junction</location>
            <location evidence="13">Gap junction</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the cytospin-A family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TBK3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005016368.1">
        <property type="protein sequence ID" value="ENSCJPP00005011170.1"/>
        <property type="gene ID" value="ENSCJPG00005009519.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153592"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031941">
        <property type="term" value="C:filamentous actin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005921">
        <property type="term" value="C:gap junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034332">
        <property type="term" value="P:adherens junction organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061713">
        <property type="term" value="P:anterior neural tube closure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030835">
        <property type="term" value="P:negative regulation of actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007026">
        <property type="term" value="P:negative regulation of microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036032">
        <property type="term" value="P:neural crest cell delamination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051897">
        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd21199">
        <property type="entry name" value="CH_CYTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000020">
        <property type="entry name" value="Cytospin-A isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050540">
        <property type="entry name" value="F-actin_Monoox_Mical"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23167">
        <property type="entry name" value="CALPONIN HOMOLOGY DOMAIN-CONTAINING PROTEIN DDB_G0272472-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23167:SF18">
        <property type="entry name" value="CYTOSPIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6 13" id="KW-0132">Cell division</keyword>
    <keyword evidence="8 13" id="KW-0965">Cell junction</keyword>
    <keyword evidence="9 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7 13" id="KW-0303">Gap junction</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="16">
        <location>
            <begin position="1031"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="23"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="96"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="318"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="378"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="875"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="940"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="263"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="431"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="508"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="177"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="378"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="956"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="966"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="991"/>
            <end position="1010"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
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            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU367063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005011170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1137" mass="127163" checksum="8E1B2957E6144FB7" modified="2022-01-19" version="1">LPLSVCRFVCKCIINRQPRMKKASRSVGSVPKVPGVNKIQTTEKTKPESGSSLSAVTKLSKPGTSASLLKTKSNDDLLAGMASGGGVTMTNGVKAKKSTCASTVSSATGTTMNTLENKPKTVAGSTAKRSTSSGTKESSSSRERIRDRSRLSQSKKLPLTGQGSNDTVLAKRSRSRTNPELDIRMSKSKSDNQISDKAALEAKVNDLLTLAKTKDVEILHLRNELRDMRAQLGLNEDQVEGDEKSEEKEAIVVHQPTDVESTLLQLQEQNTAIREELNQLKNENRMLKDRLNALGFSLEQRLDNSEKLFGYQSLSPEITVGSHSDGGGTLTSSVEGSAPGSMEDLLSQDEHTLMDNQHSNSMDNLDSECSEVYQPLTSSDDALDAPSSSESEGVPSIERSRKGSSGNTSEVSVACLTERIHQMEENQHSTAEELQATLQELADLQQITQELNSENERLGEEKVILMESLCQQSDKLEHFSRQIEYFRSLLDEHHISYVIDEDMKSGRYMELEQRYMDLAENARFEREQLLGVQQHLSNTLKMAEQDNKEAQEMIGALKERNHHMERIIESEQKSKTAIASTLEEYKATVASDQIEMNRLKAQLEHEKQKVAELYSIHNSGDKSDIQDLLESVRLDKEKAETLASSLQEELAHTRNDANRLQDAIAKVEDDYRVFQEEAKKQIEDLNVTLEKLRAELDEKETERSDMKETIFELEDEVEQHRAVKLHDNLIISDLENTVKKLQDQKHDMEREIKNLHRRLREESAEWRQFQADLQTAVVIANDIKSEAQEEIGDLKRRLHEAQEKNEKLTKELEEIKSRKQEEERGRVYNYMNAVERDLAALRQGMGLSRRSSTSSEPTPTVKTLIKSFDSASQVPSPAAATIPRTPLSPSPMKTPPAAAVSPMQRHSISGPISASKPLATLTDKRPSYAEIPVQEHLLRTSSTSRPASLPRVPAMESAKSISVSRRSSEEIKRDISAPDGASPASLMAMGTTSPQLSLSSSPTASVTPTTRSRIREERKDPLSALAREYGGSKRNALLKWCQKKTEGYQNIDITNFSSSWNDGLAFCAVLHTYLPAHIPYQELNSQDKRRNFTLAFQAAESVGIKSTLDINEMVRTERPDWQNVMLYVTAIYKYFET</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TBW4</accession>
    <name>A0A8C2TBW4_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Retinol dehydrogenase</fullName>
            <ecNumber evidence="4">1.1.1.300</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC107317369</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinal to all-trans-retinol. May play a role in the regeneration of visual pigment at high light intensity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>all-trans-retinol + NADP(+) = all-trans-retinal + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25033"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17336"/>
            <dbReference type="ChEBI" id="CHEBI:17898"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.300"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 7">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.300" evidence="4"/>
    <dbReference type="RefSeq" id="XP_015725446.1">
        <property type="nucleotide sequence ID" value="XM_015869960.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TBW4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005013834.1">
        <property type="protein sequence ID" value="ENSCJPP00005009243.1"/>
        <property type="gene ID" value="ENSCJPG00005008151.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107317369"/>
    <dbReference type="KEGG" id="cjo:107317369"/>
    <dbReference type="GeneTree" id="ENSGT00940000155412"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052650">
        <property type="term" value="F:all-trans-retinol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004303">
        <property type="term" value="F:estradiol 17-beta-dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006703">
        <property type="term" value="P:estrogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09806">
        <property type="entry name" value="type1_17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000323">
        <property type="entry name" value="Estradiol 17-beta-dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011348">
        <property type="entry name" value="17beta_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43391:SF9">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43391">
        <property type="entry name" value="RETINOL DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000095">
        <property type="entry name" value="17beta-HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0716">Sensory transduction</keyword>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000095-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000095-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005009243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="317" mass="35591" checksum="475639E2EBE40723" modified="2022-01-19" version="1">MARKTVLITGCSSGIGLALAVKMAKDEQERFKVYATMRNLAKKDALEEAVGHNLGKTLEIKQLDVCDEQSIKTCVNSIPDRRIDVLVSNAGMGLIGPIECQTIDEMKTVMDTNFFGLVRLLKEILPDMKKRKSGHIVIISSVMGIQGILFNDVYAASKFAVEGFCESLAIQALKFKLQLSLIEPGPVVTEFERKVFEDGMKMDLSAADEETAEMFTNIYLKNYKQIFQSLGQSAEEVAEHTVKIILAENPPFRHQTNTLYTPMTTLKYADPNGDLPIDTFYKMVFHHDKIFSASLNFIKLLRWRSRKSFDLGKSSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TC47</accession>
    <name>A0A8C2TC47_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chemokine interleukin-8-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TC47"/>
    <dbReference type="Ensembl" id="ENSCJPT00005015275.1">
        <property type="protein sequence ID" value="ENSCJPP00005010283.1"/>
        <property type="gene ID" value="ENSCJPG00005008988.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008009">
        <property type="term" value="F:chemokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036048">
        <property type="entry name" value="Interleukin_8-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54117">
        <property type="entry name" value="Interleukin 8-like chemokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034064906" description="Chemokine interleukin-8-like domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005010283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="105" mass="11175" checksum="3C620903AB0E1DF3" modified="2022-01-19" version="1">MAMRAALLLGLLLVVLCPGNAGEAIEGAGSPLSTTWFCASLPYGLGEMKGLGPSASPLEGKGLKPCMFSRIKLKTLERICVDPSTPWVRKLLQDLPKLRKKAAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TCI0</accession>
    <name>A0A8C2TCI0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Lanosterol 14-alpha demethylase</fullName>
            <ecNumber evidence="22">1.14.14.154</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="38" type="primary">CYP51A1</name>
    </gene>
    <organism evidence="38 39">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="38" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="38" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="38" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="32">
            <text>24,25-dihydrolanosterol + 3 reduced [NADPH--hemoprotein reductase] + 3 O2 = 4,4-dimethyl-8,14-cholestadien-3beta-ol + formate + 3 oxidized [NADPH--hemoprotein reductase] + 4 H2O + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:45960"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:28113"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:78904"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="32">
            <dbReference type="Rhea" id="RHEA:45961"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>24,25-dihydrolanosterol + reduced [NADPH--hemoprotein reductase] + O2 = 32-hydroxy-24,25-dihydrolanosterol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:75079"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:28113"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:87057"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:75080"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>32-hydroxy-24,25-dihydrolanosterol + reduced [NADPH--hemoprotein reductase] + O2 = 32-oxo-24,25-dihydrolanosterol + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:75087"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:87057"/>
            <dbReference type="ChEBI" id="CHEBI:87060"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="31">
            <dbReference type="Rhea" id="RHEA:75088"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>32-hydroxylanosterol + reduced [NADPH--hemoprotein reductase] + O2 = 32-oxolanosterol + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:75107"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:166681"/>
            <dbReference type="ChEBI" id="CHEBI:166806"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:75108"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>32-oxo-24,25-dihydrolanosterol + reduced [NADPH--hemoprotein reductase] + O2 = 4,4-dimethyl-8,14-cholestadien-3beta-ol + formate + oxidized [NADPH--hemoprotein reductase] + H2O + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:75083"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:78904"/>
            <dbReference type="ChEBI" id="CHEBI:87060"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="29">
            <dbReference type="Rhea" id="RHEA:75084"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>32-oxolanosterol + reduced [NADPH--hemoprotein reductase] + O2 = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + oxidized [NADPH--hemoprotein reductase] + H2O + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:75111"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:17813"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:166681"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="30">
            <dbReference type="Rhea" id="RHEA:75112"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="35">
            <text>a 14alpha-formyl steroid + reduced [NADPH--hemoprotein reductase] + O2 = a Delta(14) steroid + formate + oxidized [NADPH--hemoprotein reductase] + H2O + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:68068"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:138031"/>
            <dbReference type="ChEBI" id="CHEBI:176902"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="35">
            <dbReference type="Rhea" id="RHEA:68069"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>a 14alpha-hydroxymethyl steroid + reduced [NADPH--hemoprotein reductase] + O2 = a 14alpha-formyl steroid + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:68064"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:176901"/>
            <dbReference type="ChEBI" id="CHEBI:176902"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:68065"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>a 14alpha-methyl steroid + 3 reduced [NADPH--hemoprotein reductase] + 3 O2 = a Delta(14) steroid + formate + 3 oxidized [NADPH--hemoprotein reductase] + 4 H2O + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54028"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:138029"/>
            <dbReference type="ChEBI" id="CHEBI:138031"/>
            <dbReference type="EC" id="1.14.14.154"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:54029"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="33">
            <text>a 14alpha-methyl steroid + reduced [NADPH--hemoprotein reductase] + O2 = a 14alpha-hydroxymethyl steroid + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:68060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:138029"/>
            <dbReference type="ChEBI" id="CHEBI:176901"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="33">
            <dbReference type="Rhea" id="RHEA:68061"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>lanosterol + 3 reduced [NADPH--hemoprotein reductase] + 3 O2 = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + 3 oxidized [NADPH--hemoprotein reductase] + 4 H2O + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:25286"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16521"/>
            <dbReference type="ChEBI" id="CHEBI:17813"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="1.14.14.154"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:25287"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="34">
            <text>lanosterol + reduced [NADPH--hemoprotein reductase] + O2 = 32-hydroxylanosterol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:75103"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16521"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:166806"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="34">
            <dbReference type="Rhea" id="RHEA:75104"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 36">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="21">Steroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 1/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 37">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.154" evidence="22"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2TCI0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005015834.1">
        <property type="protein sequence ID" value="ENSCJPP00005010745.1"/>
        <property type="gene ID" value="ENSCJPG00005009307.1"/>
    </dbReference>
    <dbReference type="KEGG" id="cjo:107309008"/>
    <dbReference type="GeneTree" id="ENSGT00930000151026"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008398">
        <property type="term" value="F:sterol 14-demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006695">
        <property type="term" value="P:cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11042">
        <property type="entry name" value="CYP51-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000027">
        <property type="entry name" value="lanosterol 14-alpha demethylase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050529">
        <property type="entry name" value="CYP450_sterol_14alpha_dmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304:SF2">
        <property type="entry name" value="24-HYDROXYCHOLESTEROL 7-ALPHA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0152">Cholesterol biosynthesis</keyword>
    <keyword evidence="5" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 36 37" id="KW-0349">Heme</keyword>
    <keyword evidence="14 36 37" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="17" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="18" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 36 37" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16 37" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="13 37" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="39" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="20" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="15" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="19" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="36">
        <location>
            <position position="442"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00037887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00038974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00041158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00047379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00047587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00047670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00047702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00047983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00048245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00048479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00048736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00048839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="ARBA" id="ARBA00048866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="ARBA" id="ARBA00049163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="35">
        <source>
            <dbReference type="ARBA" id="ARBA00049450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="36">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="37">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="38">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005010745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="39">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="496" mass="56079" checksum="8BCD91343C0EFDAD" modified="2022-01-19" version="1">MLSLLEVGGSLLERAAVGNPLSLLLAASAFALSLGYLFQLGYRRHVGADRTNHPPYIPSSIPFLGHAIAFGKSPIEFLENAYDKYGPVFSFTMVGKTFTYLLGSDAAALLFNSKNEDLNAEDVYSRLTTPVFGKGVAYDVPNPVFLEQKKMLKTGLNIAQFKQHVTLIEEETKEYFKAWGDSGERNLFEAFSELIILTASHCLHGKEIRSLLNEKVAQLYADLDGGFTHAAWLLPTWLPLPSFRRRDRAHREIKNIFYKVIQKRRSAEEKEDDMLQTLLDASYKDGRPLTDDEIAGMLIGLLLAGQHTSSTTSAWLGFFIARDKAIQEQCYAEQKAVCGDDLPPLTYDQLKDLSLLDRCLKETLRLRPPIMTIMRLAKTPQTVAGYNIPPGHQVCVSPTVNQRLKDSWKDALDFKPDRYLQDNPAAGEKFTYIPFGAGRHRCIGENFAYVQIKTIWSTLLRLYDFDLVNDYFPSINYTTMIHTPNNPVIRYKRRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TDQ7</accession>
    <name>A0A8C2TDQ7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Neurturin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">NRTN</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Growth factor that supports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Involved in the development of the neural crest. Might control the size of non-neuronal cell population such as haemopoietic cells. Acts by binding to its coreceptor, GFRA2, leading to autophosphorylation and activation of the RET receptor. Heparan sulfate-binding is required for signaling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer; disulfide-linked. Interacts with GFRA2 coreceptor and RET: forms a 2:2:2 ternary complex composed of NRTN ligand, GFRA2 and RET receptor. Also forms a 4:4:4 tetrameric complex composed of 4 copies of NRTN ligand, GFRA2 and RET receptor, which prevents endocytosis of RET.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TGF-beta family. GDNF subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015742233.1">
        <property type="nucleotide sequence ID" value="XM_015886747.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TDQ7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005016696.1">
        <property type="protein sequence ID" value="ENSCJPP00005011438.1"/>
        <property type="gene ID" value="ENSCJPG00005009820.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107325645"/>
    <dbReference type="CTD" id="4902"/>
    <dbReference type="GeneTree" id="ENSGT00950000182993"/>
    <dbReference type="OrthoDB" id="9936891at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030116">
        <property type="term" value="F:glial cell-derived neurotrophic factor receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904399">
        <property type="term" value="F:heparan sulfate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030971">
        <property type="term" value="F:receptor tyrosine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097696">
        <property type="term" value="P:cell surface receptor signaling pathway via STAT"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035860">
        <property type="term" value="P:glial cell-derived neurotrophic factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021675">
        <property type="term" value="P:nerve development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001755">
        <property type="term" value="P:neural crest cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd19383">
        <property type="entry name" value="TGF_beta_Neurturin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.90.10:FF:000037">
        <property type="entry name" value="neurturin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043401">
        <property type="entry name" value="GDNF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001839">
        <property type="entry name" value="TGF-b_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12173">
        <property type="entry name" value="GDNF SUBFAMILY OF TGF-BETA FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12173:SF3">
        <property type="entry name" value="NEURTURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00019">
        <property type="entry name" value="TGF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00204">
        <property type="entry name" value="TGFB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51362">
        <property type="entry name" value="TGF_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0339">Growth factor</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="TGF-beta family profile" evidence="13">
        <location>
            <begin position="135"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="51"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00055869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00062854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00069369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005011438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="240" mass="26832" checksum="AF6D768FF290BC3D" modified="2022-01-19" version="1">MDRSQHCQSFNVLTCSKMKVWKFAAIASMLLSSMLSILVCRDMFNGSRTYSPLPSSPASRASSSSSSSSSLPVAPRRPPRALPRHSSLLAQYSSLLESYTEGEIRQLISALVERYSQAMNSGGHELPLFPKAGNRMKRARARHKPCALKELEVSVSELGLGYESDETVLFRYCSGTCDTAVRNYDLSLKSVRSRKKIRKEKVRARPCCRPLAYDDDVSFLDAYNRYYTVNELSAKECGCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TEG9</accession>
    <name>A0A8C2TEG9_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">USP28</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2TEG9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005018172.1">
        <property type="protein sequence ID" value="ENSCJPP00005012557.1"/>
        <property type="gene ID" value="ENSCJPG00005009822.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157670"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061136">
        <property type="term" value="P:regulation of proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02665">
        <property type="entry name" value="Peptidase_C19I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14355">
        <property type="entry name" value="UBA_UBP28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20487">
        <property type="entry name" value="USP28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000004">
        <property type="entry name" value="Putative ubiquitin carboxyl-terminal hydrolase 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044635">
        <property type="entry name" value="UBP14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054108">
        <property type="entry name" value="USP25/28_UIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982:SF6">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21909">
        <property type="entry name" value="USP_UIM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="11">
        <location>
            <begin position="140"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="40"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="438"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="478"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="662"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="751"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="377"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="438"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="478"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="673"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="762"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005012557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1103" mass="124848" checksum="90D35ACF254F0CBB" modified="2022-01-19" version="1">QVLNKMKEITGIQDADFLHAALKAAKGNLMEALIVLTEERDQEPVQNTTAAEPSSWEGSAVGKEPPQGGAAFDPEKKGDHSAVAYRQLESPKARAAERLVMLPQEVHSPESKNRSKRKRCEVWGENSKQSDWKRVGDWPVGMKNIGNTCWFSAVIQSLFQLPQFRRLVLSYSFPPSALESCRTNIAFMQELQCLFALMLGTRRKFVDPSAALELLRDAFKSTEEQQQDVSEFTHKLLDWLEDAFQLAVNVNPGDKSENPMVQLFYGTFLTEGVHEGNTFSKIETFGQYPLQVNGYRNLNECLEGAMVEGEMDEETASQSVKYVQERWFTKLPPVLTFELSRFEFNQSLGQPEKIHTKLEFPQTIYMDRYLYCSKELIQTKREEMKKLKEKMLILQQKLERYMKYGSGPARFPLPDMLQYVLEFVTTKPAGAVSSACVSSTEDSQMMDRQSQGESLILGTPSQPDRLVNGSKTALLANSSPQQQLNTPLQPSGPPAEISDCPAPHVASEEEMNLVTTCLQRWRKEIEQDVRDLKESIARISLSIDEMYSDPHLQQVPYHLHAVLVHEGQANAGHYWAFVYDQSRKSWLKYNDISVTESSWEELERDSFGGLRNASAYCLMYISDKVSHVAAGSELMQLQEEVEALPPELRRYIQEDNWRLEQEAEEWEEEQSCKIPSTSSESQELSPESGLGDSLRSLSSEHAMIAKEQTAKAIANAADVYEKKGVEAALCEPKEVEPMKAQPGETAFTVQAEQPQDVKETESAAQSSSQISEVEIPSVGKVPVRSDADGYNEEVMLSPAMQGVILAIAKARQTFDRDGSEAGLVKAFHEEYSRLYLLSKETPTPQNDARLQHVLIYFLQNDAPQQIVERTLLEQFADKNLSYDERSISIMKVARDKLKEIGPDEVNMEEYKKWHEDYSLFRKVSVYLLTGLELYQNRKYKESLTYLIYAYQSNTALLKKGANRGVNESLITLYRRKCLLKLNEVASSLFVSCEEADVAEGISILNELIIPCVHLINNFDISREDMDAIEVMRNCWCSYLGREDMDASLQIRLGELLPRLLDGSTEVVILKEPPKIRPNSPYDLCSRFAAVMESIHDASTVTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TG37</accession>
    <name>A0A8C2TG37_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">SIM bHLH transcription factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">SIM1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Transcriptional factor that may have pleiotropic effects during embryogenesis and in the adult.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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    <dbReference type="RefSeq" id="XP_015714353.1">
        <property type="nucleotide sequence ID" value="XM_015858867.2"/>
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        <property type="protein sequence ID" value="ENSCJPP00005010959.1"/>
        <property type="gene ID" value="ENSCJPG00005009469.1"/>
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    <dbReference type="GeneTree" id="ENSGT00940000156143"/>
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        <property type="component" value="Chromosome 3"/>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:protein heterodimerization activity"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:nervous system development"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0001657">
        <property type="term" value="P:ureteric bud development"/>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="SIM bHLH transcription factor 2"/>
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        <property type="entry name" value="SIM bHLH transcription factor 2"/>
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        <property type="entry name" value="single-minded homolog 1 isoform X1"/>
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        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
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        <property type="entry name" value="PAS domain"/>
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        <property type="entry name" value="bHLH_dom"/>
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        <property type="entry name" value="HLH_DNA-bd_sf"/>
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        <property type="entry name" value="PAS_fold"/>
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        <property type="entry name" value="PAS_fold_3"/>
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        <property type="entry name" value="SIM_C"/>
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        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR23043:SF22">
        <property type="entry name" value="SINGLE-MINDED HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="bHLH_HIF1A"/>
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        <property type="entry name" value="SIM_C"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
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        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
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    </dbReference>
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        <property type="entry name" value="BHLH"/>
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    </dbReference>
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        <property type="entry name" value="SIM_C"/>
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    </dbReference>
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    <keyword evidence="5" id="KW-0524">Neurogenesis</keyword>
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    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
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    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
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            <begin position="1"/>
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        </location>
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            <begin position="372"/>
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        </location>
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        <location>
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            <dbReference type="ARBA" id="ARBA00004123"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
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            <dbReference type="ARBA" id="ARBA00022737"/>
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            <dbReference type="ARBA" id="ARBA00022902"/>
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            <dbReference type="ARBA" id="ARBA00023015"/>
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            <dbReference type="PROSITE" id="PS50112"/>
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            <dbReference type="PROSITE" id="PS51302"/>
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            <dbReference type="Ensembl" id="ENSCJPP00005010959.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="766" mass="86075" checksum="36BB56DD55706476" modified="2022-01-19" version="1">MKEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRVVFPEGLGEAWGHSSRTSPLDNVGRELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELTGNSIYEYIHPADHDEMTAVLTAHQPYHSHFVQEYEIERSFFLRMKCVLAKRNAGLTCGGYKVIHCSGYLKIRQYSLDMSPFDGCYQNVGLVAVGHSLPPSAVTEIKLHSNMFMFRASLDMKLIFLDSRVAELTGYEPQDLIEKTLYHHVHGCDTFHLRCAHHLLLVKGQVTTKYYRFLAKHGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLTDTEYKGLQLSLDQVTATKPAFSYANSTPTITDNRKGSKSRLSSTKSKSRTSPYPQYSGFHTERSESDHESQWGGSPLTDTASPQLLEPADRPSSQHHDVSCAYRQYSDRSALCYGFALDHSRLGDDRHFHTQACEGGRCEAGRYFLGTPQPGREGWWGSRSALPLTKSSPESREAYENSMPHITSVHRIHGRGHWDEDSVVSSPDPGSASESGDRYRAEQYQSSPHEPSKIETLIRATQQMIKEEENRLQLRKTTPDPLLSINGTGKKHTICFANYPQQQLAGDICRVPTVANTPPCEHVQQRDGKIMSPHENDYDHSPTTLSRISSPNSDRISKSSLVLAKDYLNTDMSPHQTPGDHPATSPNYYNSHRQYFDKHAYTLTGYALEHLYDTETIRNYSLGCNGSHFDVTSHLRMQQDPTQGHKGTSVIITNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TG86</accession>
    <name>A0A8C2TG86_COTJA</name>
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        <submittedName>
            <fullName evidence="2">Chromosome 1 open reading frame 159</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="primary">C1orf159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="component" value="Chromosome 21"/>
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        <property type="entry name" value="DUF4501"/>
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        <property type="entry name" value="RIKEN CDNA 9430015G10 GENE"/>
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        <property type="entry name" value="DUF4501"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005013303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="215" mass="23717" checksum="56D2A5DE5E03B9A1" modified="2022-01-19" version="1">VDMLESNSSCPVANQCSPGCYRRWNEDGSSSCIKCKNETLPVASVYNLTDCRNSESFIILGMNFQMNISTVTPFIQNIGGPEVAASLILGTFFISLFLILSVASFFYLKRANKLPNVFYRRNKGKILLSNCLKTRLKRFVPPRQGKITTSPCCVLSASFFFAAEQRMHASAAGANDVSLPTVSVRKPRYVRRERSLVTSASAAMISSSETRVSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TGM0</accession>
    <name>A0A8C2TGM0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I and III subunit RPAC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">POLR1C</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TGM0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005019331.1">
        <property type="protein sequence ID" value="ENSCJPP00005013466.1"/>
        <property type="gene ID" value="ENSCJPG00005011351.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183100"/>
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        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001650">
        <property type="term" value="C:fibrillar center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07032">
        <property type="entry name" value="RNAP_I_II_AC40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.120.12:FF:000003">
        <property type="entry name" value="Dna-directed rna polymerases i and iii subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.10:FF:000005">
        <property type="entry name" value="Dna-directed rna polymerases i and iii subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="entry name" value="DNA-directed RNA polymerase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00320">
        <property type="entry name" value="RNApol_arch_Rpo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001514">
        <property type="entry name" value="DNA-dir_RNA_pol_30-40kDasu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022842">
        <property type="entry name" value="RNAP_Rpo3/Rpb3/RPAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033901">
        <property type="entry name" value="RNAPI/III_AC40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050518">
        <property type="entry name" value="Rpo3/RPB3_RNA_Pol_subunit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001988">
        <property type="entry name" value="PRK00783.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800:SF13">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="Insert subdomain of RNA polymerase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00446">
        <property type="entry name" value="RNA_POL_D_30KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RpoA/D/Rpb3-type" evidence="8">
        <location>
            <begin position="145"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005013466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="439" mass="48766" checksum="9C2EE8238EC9E125" modified="2022-01-19" version="1">MHGSSAPARAPLSPPPRAGPTCTLSSKPPHSAVPLLPPAAAIAPVTGDGNADVTVRPLRVSREPSVPHGRLTCGGAGRRRVLPSAMAARRGTDEMRERVVLGEFGVRNVHTTDFPGNYPGYDDAWDQRRFEEGFRVDVVREEDGVLEFDMVGIDAAIANAFRRILLAEVPTMAVEKVFVYNNTSIVQDEILAHRLGLIPIRADPRLFEYRNQGDEEGTEIDTLQFQLKIKCSRNPQAAKESSDPNELYFNHKVYSKHMTWVPLGNQTDLFPDADFRPVHDDILIALLRPGQEIDVLMHCVKGVGKDHAKFSPVATASYRLLPDITLLQPIEDEAAETLQKCFSPGVIEIQNVKGKKVARVANARLDTFSREVFRHEGLKNLVRLARVRNHYIFSVESTGILPPDVLVTEAIKILMGKCQRFLNELDAVPMEHEFGDGFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2THE3</accession>
    <name>A0A8C2THE3_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Tigger transposable element derived 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">TIGD5</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tigger transposable element derived protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015711903.1">
        <property type="nucleotide sequence ID" value="XM_015856417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2THE3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005018222.1">
        <property type="protein sequence ID" value="ENSCJPP00005012595.1"/>
        <property type="gene ID" value="ENSCJPG00005010714.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107310608"/>
    <dbReference type="KEGG" id="cjo:107310608"/>
    <dbReference type="CTD" id="84948"/>
    <dbReference type="GeneTree" id="ENSGT00940000154420"/>
    <dbReference type="OrthoDB" id="5919228at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021556">
        <property type="term" value="P:central nervous system formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007379">
        <property type="term" value="P:segment specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000293">
        <property type="entry name" value="Tigger transposable element-derived protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF56">
        <property type="entry name" value="TIGGER TRANSPOSABLE ELEMENT-DERIVED PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04218">
        <property type="entry name" value="CENP-B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50960">
        <property type="entry name" value="HTH_PSQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH psq-type" evidence="7">
        <location>
            <begin position="132"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="HTH CENPB-type" evidence="8">
        <location>
            <begin position="197"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="5">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="581"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="10"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="587"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="610"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005012595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="676" mass="71105" checksum="6ACFEB6C18237CD3" modified="2022-01-19" version="1">MAGEEEEVGGGKAGIAGGRKGGGGGGGGSSNGGGSSNGRGTSNGGGGVGSSNGRGISNGDGGVGSSNGRGTSNGRGTSNGDGGGGTSNGGGISNGGGTSNSCVGGGTSDGKGVGGSSSNGSGISNGGGVGVSMKMAFRRAYSIKDKLHAIERVKKGERQASVCRAFGVPGGTLRGWLKDEAKLRWFLEQLGGEVGTQRKKMRLANEEEIDRAVYAWFLALRQHGVPLSGPLIQAQAEAFARQIYGPECTFKASHGWFWRWQKRHGISSQRIYGEGALHAEPERTSIAHPNLPTTPGSDTGGYGDEQIYNANITGLYWKLLPGRTAPRQRVTVLLVANLTGTHKLKPLVVGGLRDPPSLCHHNQEKFPAGYRYSPEARLGPALLRVWFYEDFVPCVKRYLRRSCLQQKAVLLLTSPPSSGGRHHEDLPQLQTPDGSIRALFLSKSPTGNSSTGGGSRIPTPLEQGVVSAFKQFYKRELLRLAISAGGPVDFARSFLLKDMLYLAGLSWDLIPPNAIEKCWLLGLRAAFEPQPGEEERGGGDCTSGEEGNGDGKIFNDLTQLAALAYKRLAPEEVANWLHLDDMAPGMGEDDEDEDAMEEDPGGCKEEEEGAGGGDNGAGEGGSPLMPTAHEAIRGLETALRWLEGQDPRRVGPLKLVQLRSLISMAQRLHRGSSPDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2THH9</accession>
    <name>A0A8C2THH9_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphatidylcholine-sterol acyltransferase</fullName>
            <ecNumber evidence="11">2.3.1.43</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Lecithin-cholesterol acyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Phospholipid-cholesterol acyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LCAT</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a sterol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sterol ester + a 1-acyl-sn-glycero-3-phosphocholine</text>
            <dbReference type="Rhea" id="RHEA:21204"/>
            <dbReference type="ChEBI" id="CHEBI:15889"/>
            <dbReference type="ChEBI" id="CHEBI:35915"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="2.3.1.43"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.43" evidence="11"/>
    <dbReference type="RefSeq" id="XP_015729220.1">
        <property type="nucleotide sequence ID" value="XM_015873734.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2THH9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005019784.1">
        <property type="protein sequence ID" value="ENSCJPP00005013804.1"/>
        <property type="gene ID" value="ENSCJPG00005011612.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107319111"/>
    <dbReference type="KEGG" id="cjo:107319111"/>
    <dbReference type="CTD" id="3931"/>
    <dbReference type="GeneTree" id="ENSGT00940000160052"/>
    <dbReference type="OrthoDB" id="190846at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034364">
        <property type="term" value="C:high-density lipoprotein particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003847">
        <property type="term" value="F:1-alkyl-2-acetylglycerophosphocholine esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034186">
        <property type="term" value="F:apolipoprotein A-I binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004607">
        <property type="term" value="F:phosphatidylcholine-sterol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047179">
        <property type="term" value="F:platelet-activating factor acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004771">
        <property type="term" value="F:sterol ester esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042632">
        <property type="term" value="P:cholesterol homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034375">
        <property type="term" value="P:high-density lipoprotein particle remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043691">
        <property type="term" value="P:reverse cholesterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034372">
        <property type="term" value="P:very-low-density lipoprotein particle remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000445">
        <property type="entry name" value="Lecithin-cholesterol acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000090">
        <property type="entry name" value="Phosphatidylcholine-sterol acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003386">
        <property type="entry name" value="LACT/PDAT_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11440">
        <property type="entry name" value="LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02450">
        <property type="entry name" value="LCAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="17" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="7" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034911850" description="Phosphatidylcholine-sterol acyltransferase" evidence="17">
        <location>
            <begin position="25"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="424"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00040526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00041412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00042279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00050812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005013804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="460" mass="52632" checksum="FA6FCD57F36ECBAE" modified="2022-01-19" version="1">MGRTGAGLTLLTLLLVLLLQPTSQFWLFNVLFPPTTTPEAPPTNSTPPVVLVPGCLGNQLEAKLDKPDVVNWMCYRKTEDYFTIWLNLNTFLPVGVDCWIDNTRVVYNRTARKMTNAPGVHIRVPGFGKTYSVEYLDQSKLAGYLHTLVQNLVNNGYVRDQTVRAAPYDWRVGPQEQPEYFQNLKALIEEMHDEYQQRVFLIGHSMGNLNVLYFLLQQKQAWKDQYIGGFISLGAPWGGSVKPLRVLASGDNQGIPLMSNIKLREEQRMTTTSPWMFPTSLAWPEDHVFISTPSYNYTYRDYQRFFTDVNLEDGWYMWEDMKDLLKGLPPPGVDTYCLYGTGYPTVETYIYDEHFPYEDPVDMIYGDGDDTVNKRSSELCKRWRNQQKQKVHVQELRGIDHLNMVFSNLTLTSINEILLGSTKVGAGTKEKGEPEQTGALRSSPEVGRKGHKVFKEPRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TIS9</accession>
    <name>A0A8C2TIS9_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tetratricopeptide repeat domain 39A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">TTC39A</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TTC39 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TIS9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005017811.1">
        <property type="protein sequence ID" value="ENSCJPP00005012279.1"/>
        <property type="gene ID" value="ENSCJPG00005010447.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182917"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019412">
        <property type="entry name" value="IML2/TPR_39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859:SF3">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10300">
        <property type="entry name" value="Iml2-TPR_39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034390655" evidence="3">
        <location>
            <begin position="20"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005012279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="529" mass="59938" checksum="135771A5B98095DB" modified="2022-01-19" version="1">MLALSLAVLGLQAAPGSPASDLNVALHECMAALDLFLSNKFSDALASLQAKTKDSMYHALTYATILEISVTKEIHAEICYAECLLQRAALTFLQDENMVSFIKGGIKVRNSYQTYRELDSLIQSPHYVKGENHLHFEGGVKLGVGAFNLTLSMFPARILRLLEFVGFSGNKERGLLQLQEGASSYSFRSVLCTMLLLCYHTFMTFVLGTGKGNVEEAERLLKPYLARYPKGAIFLFFAGRIETLKGNIDAAVNRYEECCEAQQYWKQFHHMCYWELMWCFTYKRQWKMAFFYADLLSKENTWSKATYIYMKAAYLSMFGPDDCSPFGDNEVELFRIVPSLKLKIAGKSLPTEKFAIRKARRYLSSNPIPLPVPPLEMMYIWNGYAVIGQCPNLTEGMLETLIEAEEALARSSATELLADDQCVIKLLKGLCLKHLGKISEAEGHFNYIYLNEKKIKYDHYLIPNALLELALLYLDQDRREEAIKLLERAKQNYKNYSMETRTHFRIQAALHQAKSAPENGTHSGASAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TLK9</accession>
    <name>A0A8C2TLK9_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dynein regulatory complex protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Coiled-coil domain-containing protein 164</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">DRC1</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with CCDC65/DRC2 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Flagellum axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DRC1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TLK9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005022236.1">
        <property type="protein sequence ID" value="ENSCJPP00005015731.1"/>
        <property type="gene ID" value="ENSCJPG00005012988.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153804"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070286">
        <property type="term" value="P:axonemal dynein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060285">
        <property type="term" value="P:cilium-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003352">
        <property type="term" value="P:regulation of cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039505">
        <property type="entry name" value="DRC1/2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039750">
        <property type="entry name" value="DRC1/DRC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029440">
        <property type="entry name" value="DRC1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21625:SF1">
        <property type="entry name" value="DYNEIN REGULATORY COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21625">
        <property type="entry name" value="NYD-SP28 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14772">
        <property type="entry name" value="NYD-SP28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14775">
        <property type="entry name" value="NYD-SP28_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="5 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0282">Flagellum</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein regulatory complex protein 1/2 N-terminal" evidence="12">
        <location>
            <begin position="115"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein regulatory complex protein 1 C-terminal" evidence="13">
        <location>
            <begin position="686"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="480"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="591"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="658"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="173"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="250"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="350"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="70"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="487"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="615"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="660"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="670"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF14775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="772" mass="89583" checksum="4769F05EF5522212" modified="2022-01-19" version="1">MGMANGAGIHHSWMSSSSFLHFSGHIEAAESFSLCWDGVTSFARLSRNFREIEVQMILSFFPLLPRQELGEDEEPKEEDEDVEEERNSHKEVEEIRQKLAKLLFEGIRMVTEIQVATDLRETQRRAEQAELKKQRVEKLENVAKYSAEKFEEITSKWALAKDMTIPQDLWQLLNQQQQLCTQLLDEKNKLIGELQQELKNKDEQYVQTIKKQSDDIHLLLERMEEQTRMMLRTYRHNIHQIEKTFEHERRELLDNNRKKWEEAIQDLNTKELEYLHSRVSKIEEFEKELNQLRLRDEEEYNSMKIHLENDVQNLERQIQHMKAVYLINQEKLEYNLQVLRKQDEENTIIRAQQKRKLNRLNSLLSNLRKKLVKQEKQFREENQSLVAECERINGRCKDVQRKMRHFAACDADKFVKVWLMNEEEAKGLMRKALDADRIIHTQQLGLPWEEPHYWFLNNVGPCGQYKAKKTASKLAAEVLTESTSGAQEKKEKEEVGSGEGRKENIAKAGDTINPLQNISKRTAKRILELVSDESGFLIERKLLGPLRALGKHDCTLLRLDSIFSALEIDSEDDLYQLMDFFLKYKAREGALSQSQGSPGGEDITDLSKDRAGGASSAQSDELQSSQGPLGSLPSVYLHADDVLKILKAFVQDFHKLREEEEKEEEEEEDSSPKEVLQVRDSSKDGEYWEALTHVIPEPTLKLWDALAAALEEYHNILTRRANLIAEADVLQQQNSELNLMLEQFISSGVNSMLLSPPVQQMDLNLPHPGEPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TM03</accession>
    <name>A0A8C2TM03_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Leucine-rich repeat and fibronectin type-III domain-containing protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LRFN5</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Cell adhesion molecule that mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Promotes neurite outgrowth in hippocampal neurons.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the LRFN family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015721466.1">
        <property type="nucleotide sequence ID" value="XM_015865980.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TM03"/>
    <dbReference type="Ensembl" id="ENSCJPT00005020963.1">
        <property type="protein sequence ID" value="ENSCJPP00005014769.1"/>
        <property type="gene ID" value="ENSCJPG00005012299.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107315531"/>
    <dbReference type="CTD" id="145581"/>
    <dbReference type="GeneTree" id="ENSGT00940000158296"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098982">
        <property type="term" value="C:GABA-ergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098839">
        <property type="term" value="C:postsynaptic density membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050728">
        <property type="term" value="P:negative regulation of inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043031">
        <property type="term" value="P:negative regulation of macrophage activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905606">
        <property type="term" value="P:regulation of presynapse assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099560">
        <property type="term" value="P:synaptic membrane adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05764">
        <property type="entry name" value="IgI_SALM5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000025">
        <property type="entry name" value="Leucine rich repeat and fibronectin type III domain containing 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000235">
        <property type="entry name" value="Leucine-rich repeat and fibronectin type III domain-containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000091">
        <property type="entry name" value="Leucine-rich repeat and fibronectin type III domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000016">
        <property type="entry name" value="Leucine-rich repeat and fibronectin type III domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050467">
        <property type="entry name" value="LRFN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45842:SF10">
        <property type="entry name" value="LEUCINE-RICH REPEAT AND FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45842">
        <property type="entry name" value="SYNAPTIC ADHESION-LIKE MOLECULE SALM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 16" id="KW-0732">Signal</keyword>
    <keyword evidence="3 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034974217" description="Leucine-rich repeat and fibronectin type-III domain-containing protein 5" evidence="16">
        <location>
            <begin position="18"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="525"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="17">
        <location>
            <begin position="287"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="385"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="606"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="619"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="655"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="727"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00067171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005014769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="737" mass="80506" checksum="89344FE450EC834B" modified="2022-01-19" version="1">MEKLLLFLLFIGIAVRAQICPKRCVCQILSPNLATLCAKKGLLFVPPNIDRRTVELRLADNFVTNIKRKDFANMTSLVDLTLSRNTISFITPHAFADLRNLRALHLNSNRLTKITNDMFSGLSNLHHLILNNNQLTLISSTAFDDVLALEELDLSYNNLETIPWDAVEKMVSLHTLSLDHNMIDHIPKGTFSHLHKMTRLDVTSNKLQKLPPDPLFQRAQVLATSGIISPSTFALSFGGNPLHCNCELLWLRRLSREDDLETCASPQLLSGRYFWSIPEEEFLCEPPLITRHTHELRVLEGQRAALRCKARGDPEPAIHWISPEGKLISNATRSVVYDNGTLDILITTVKDTGSFTCIASNPAGEATQTVDLHIIKLPHLLNSTNHIHEPDPGSSDISTSTKSGSNASSSNGDTKVSQDKKVVVAEATSSTALLKFNFQRNIPGIRMFQIQYNGTYDDSLVYRMIPPTSKTFLVNNLAAGTMYDLCVLAIYDDGITSLTATRVVGCTQFTTEQDYVRCHFMQSQFLGGTMIIIIGGIIVASVLVFIIILMIRYKVCNNNGQHKATKVSNVYSQTNGAQVQGCGGVLSQSASKQAVGHDEAAQCCRAASDGAGPSPELSPGPEATATTTSPSPHAWAAGTSAAQKPKRKPGPKPSSEPQSEAATSIESQNTNRNNSTALQLASRPPDSDKGVPTYKRAQSKPKAGADLKDTHTAPLPESNCPSVVTRQKTKRSQCTKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TMM7</accession>
    <name>A0A8C2TMM7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">procollagen-lysine 5-dioxygenase</fullName>
            <ecNumber evidence="5">1.14.11.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">PLOD2</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-lysyl-[collagen] + 2-oxoglutarate + O2 = (5R)-5-hydroxy-L-lysyl-[collagen] + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:16569"/>
            <dbReference type="Rhea" id="RHEA-COMP:12751"/>
            <dbReference type="Rhea" id="RHEA-COMP:12752"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:133442"/>
            <dbReference type="EC" id="1.14.11.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Lumenal side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Rough endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.14.11.4" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2TMM7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005021252.1">
        <property type="protein sequence ID" value="ENSCJPP00005014970.1"/>
        <property type="gene ID" value="ENSCJPG00005012444.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234558"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005791">
        <property type="term" value="C:rough endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008475">
        <property type="term" value="F:procollagen-lysine 5-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046947">
        <property type="term" value="P:hydroxylysine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001666">
        <property type="term" value="P:response to hypoxia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00761">
        <property type="entry name" value="Glyco_tranf_GTA_type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.620:FF:000004">
        <property type="entry name" value="Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000249">
        <property type="entry name" value="Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050757">
        <property type="entry name" value="Collagen_mod_GT25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057589">
        <property type="entry name" value="GT_PLOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001006">
        <property type="entry name" value="Procol_lys_dOase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10730:SF6">
        <property type="entry name" value="PROCOLLAGEN-LYSINE,2-OXOGLUTARATE 5-DIOXYGENASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10730">
        <property type="entry name" value="PROCOLLAGEN-LYSINE,2-OXOGLUTARATE 5-DIOXYGENASE/GLYCOSYLTRANSFERASE 25 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25342">
        <property type="entry name" value="GT_PLOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01325">
        <property type="entry name" value="LYS_HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0847">Vitamin C</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="16">
        <location>
            <begin position="745"/>
            <end position="838"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005014970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="838" mass="95457" checksum="D98F2DE5B147F906" modified="2022-01-19" version="1">MVLFRSAAPVAPPGALAARVLPPPYKAWGGRQRPTLCPPRRRSGNPARHRLLLAAFFPFLPSPPSGLAARGAAAAAAVRRGKMAWNGARPPRLLLPLLLALALPAAAERSPGPGPADNLLVFTVATKETDGFHRFMQTAKHFNYTVKVLGKGEEWKGGELANSIGGGQKVRLLKEGIQSYADQEDLIVMFVECYDVIFAGGPEELLKKFQETSHKVVFAADGLIWPDKRLADKYPVVRSGKRFLNSGGFIGYAPYINRIVQQWNLQDNDDDQLFYTKIYVDPLARERLNITLDHKCAIFQTLNGAVDEVHLNFEEGKVRARNSMYETLPITVLGNGPTKIYLNYLGNYIPNAWTRETGCSICDLDMLDLSTVTEYPRVKIGVFIEQPTPFLPKFLDRLLTLDYPKEALSVFIHNNEVYHEKHIKKFWEKAKNMIRNIKIVGPEENLSQAEARNMGMDLCRQDDACEYYFSIDADVVLTNPKTLKILIEQNRKIIAPLVTRHGKLWSNFWGALSPDGYYARSEDYIDIVQGNRVGVWNIPYMANIYLIKGQTLRSEMKEKNYFMRDKLDPDMALCRNAREMTLQREKDSPSSETFHMLRPPKGVFMYITNRHEFGRLISTANYNTSHYNNDLWQIFENPVDWKETYINPNYSKIFTDNIVEQPCPDVFWFPIFSDTACDELVEEMEHFGQWSGGKHQDSRISGGYENVPTDDIHMKQIGLDNEWLHFIREFIAPVTLKVFAGYYTKGFALLNFVVKYSPDRQRSLRPHHDSSTFTINIALNKVGEDFQGGGCKFLRYNCSIESPRKGWSFMHPGRLTHLHEGLPILNGTRYIAVSFIDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TP46</accession>
    <name>A0A8C2TP46_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Synaptotagmin-12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Synaptotagmin XII</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">SYT12</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Synaptic vesicle phosphoprotein that enhances spontaneous neurotransmitter release but does not effect induced neurotransmitter release. Unlike other synaptotagmins, it does not bind Ca(2+) or phospholipids. Essential for mossy-fiber long-term potentiation in the hippocampus.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer. Can also form heterodimers. Interacts with SYT1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Secretory vesicle</location>
            <location evidence="1">Synaptic vesicle membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synaptotagmin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TP46"/>
    <dbReference type="Ensembl" id="ENSCJPT00005023413.1">
        <property type="protein sequence ID" value="ENSCJPP00005016699.1"/>
        <property type="gene ID" value="ENSCJPG00005013700.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158627"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048791">
        <property type="term" value="P:calcium ion-regulated exocytosis of neurotransmitter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048488">
        <property type="term" value="P:synaptic vesicle endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08406">
        <property type="entry name" value="C2B_Synaptotagmin-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000080">
        <property type="entry name" value="Putative synaptotagmin-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000129">
        <property type="entry name" value="Synaptotagmin 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030537">
        <property type="entry name" value="Syt12_C2B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024">
        <property type="entry name" value="SYNAPTOTAGMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024:SF252">
        <property type="entry name" value="SYNAPTOTAGMIN-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="15">
        <location>
            <begin position="131"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="15">
        <location>
            <begin position="262"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00056186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00064535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00067732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00081192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005016699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="395" mass="43462" checksum="AFAF66B9C0B57005" modified="2022-01-19" version="1">RWEIGIYAAGALALLGIAAVNLWKLWRSGSYPAPSPFPNYDYRYLEQKYGTAYSDIKHKRGAAACSLKPLPSRKASLRGADTCESINELGSLELMSRDLGLAPYGPLKKSVSADSLNSVSSIGNNFGQDFTVGQVEVSMEYDGKAAALHVTLLQGKDLLEKEDARFESCFMRISLLPAEQIVGISRIQRSAYAVAFDERFSIPLDPAALEEDSLRFSVFGIDEDERNVSTGVAELKLSDLDLTVRPFNAWLYLQDMNKTVDTVGEILLSLSYLPTAERLTVVVVKAKNLIWSNGKGTADPFVKVYLLQDGRKISKKKDDTNPVFNEAMIFSVPAIVLQDLSLRVTVAESGEDGRADNVGHVLIGPAASGMGITHWNQMLATLRKPVSMWHPLRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TPF2</accession>
    <name>A0A8C2TPF2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DPY30 domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">DYDC1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Functions as part of axonemal radial spoke complexes that play an important part in the motility of sperm and cilia. Plays a crucial role during acrosome biogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the axonemal radial spoke complex 1 (RS1), at least composed of spoke head proteins RSPH1, RSPH3, RSPH9 and the cilia-specific component RSPH4A or sperm-specific component RSPH6A, spoke stalk proteins RSPH14, DNAJB13, DYDC1, ROPN1L and NME5, and the anchor protein IQUB. Interacts with SH3GL3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Flagellum axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dpy-30 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015721573.1">
        <property type="nucleotide sequence ID" value="XM_015866087.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015721579.1">
        <property type="nucleotide sequence ID" value="XM_015866093.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032301413.1">
        <property type="nucleotide sequence ID" value="XM_032445522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TPF2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005021647.1">
        <property type="protein sequence ID" value="ENSCJPP00005015241.1"/>
        <property type="gene ID" value="ENSCJPG00005012658.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107315590"/>
    <dbReference type="KEGG" id="cjo:107315590"/>
    <dbReference type="CTD" id="143241"/>
    <dbReference type="GeneTree" id="ENSGT00940000167117"/>
    <dbReference type="OrthoDB" id="432281at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22966">
        <property type="entry name" value="DD_DYDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.890.10:FF:000009">
        <property type="entry name" value="DPY30 domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.890.10">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007858">
        <property type="entry name" value="Dpy-30_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049630">
        <property type="entry name" value="DYDC-like_DD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037856">
        <property type="entry name" value="Sdc1/DPY30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23356:SF16">
        <property type="entry name" value="DPY30 DOMAIN CONTAINING 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23356">
        <property type="entry name" value="DPY30-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05186">
        <property type="entry name" value="Dpy-30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0282">Flagellum</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="88"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00058296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00062391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="210" mass="24833" checksum="69959B66F3C486B9" modified="2022-01-19" version="1">MESQYLRRCLGSCLKKGLAEVVERRPADPIEYLAHWIYNYKKTLEEEKKRTLERAKLEKERQAALEELEMLRKMKEEELLIQQKLEEQRQEQEREKMEQQNKEENMQEQQKDPEEDEKTIAELTDRAGAPNLPTVEEVDESGVSEVSVWKEKGYMELMLKHFLADKWKTKTVLVNPIPVLYYNLKGYYLGHSLHAVLRLYILKGCLCGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TPY4</accession>
    <name>A0A8C2TPY4_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">EEF1A lysine methyltransferase 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">EEF1AKMT4</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Protein-lysine methyltransferase that efficiently catalyzes three successive methylations on 'Lys-36' in eukaryotic translation elongation factor 1 alpha (EEF1A1 or EEF1A2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-lysyl-[protein] + S-adenosyl-L-methionine = N(6)-methyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51736"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:13053"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(6),N(6)-dimethyl-L-lysyl-[protein] + S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54200"/>
            <dbReference type="Rhea" id="RHEA-COMP:13826"/>
            <dbReference type="Rhea" id="RHEA-COMP:13827"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(6)-methyl-L-lysyl-[protein] + S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54196"/>
            <dbReference type="Rhea" id="RHEA-COMP:13053"/>
            <dbReference type="Rhea" id="RHEA-COMP:13827"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TPY4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005023475.1">
        <property type="protein sequence ID" value="ENSCJPP00005016756.1"/>
        <property type="gene ID" value="ENSCJPG00005013748.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000164140"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000111">
        <property type="entry name" value="EEF1A lysine methyltransferase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051419">
        <property type="entry name" value="Lys/N-term_MeTrsfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176:SF80">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="11">
        <location>
            <begin position="65"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00052410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00059299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005016756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="258" mass="29413" checksum="EC9AD3E57B05D5E9" modified="2022-01-19" version="1">IGQPLQPRAPPRCPPPAAARCYARRRFWEQRYRRDGAEHHEWLGGLQRFRAVLEPELRRHDRILVLGCGTSALSYELHELGYPDVTSIDFSPACVEAMSSRYAHCPDLRWAVMDMRSLTFPDASFDVVLEKGTLDVLLVEETDPWHVSPRGAAAMHRVLAEVSRVLRPGGRFLSITFAQPHFRIPHYAQEAFGWSLRHTACGDTFHYFVYIMCKGQPLDPHHLALGRQLGRPPPAPPPLFTMAEDEDEDEDFLHAIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TQ87</accession>
    <name>A0A8C2TQ87_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">GPX2</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TQ87"/>
    <dbReference type="Ensembl" id="ENSCJPT00005022785.1">
        <property type="protein sequence ID" value="ENSCJPP00005016175.1"/>
        <property type="gene ID" value="ENSCJPG00005013310.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160477"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045171">
        <property type="term" value="C:intercellular bridge"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047066">
        <property type="term" value="F:phospholipid-hydroperoxide glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592:SF36">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000303">
        <property type="entry name" value="Glutathion_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01011">
        <property type="entry name" value="GLUTPROXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 7" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000303-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005016175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="172" mass="19454" checksum="FD16414C1BA76D2F" modified="2022-01-19" version="1">MSVPIAKSFYDLSATSLQGEKVDFNVFRGRVVLIENVASGCCGVEEDTAQPCYPYQENGTNEEILNCLKHVRPGGGFEPNFTLFQKCQVNGKDTHPVFAYLKAHLPAPVDEADHLMADPRFLVWSPVRRSDISWNFEKFLVGPEGEPFRRYSPRLPTIQIEPDIQRLLKLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TQC4</accession>
    <name>A0A8C2TQC4_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13 14">X-ray repair cross-complementing protein 5</fullName>
            <ecNumber evidence="14">3.6.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">XRCC5</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Single-stranded DNA-dependent ATP-dependent helicase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the ku80 family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="14"/>
    <dbReference type="RefSeq" id="XP_015724172.1">
        <property type="nucleotide sequence ID" value="XM_015868686.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TQC4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005022363.1">
        <property type="protein sequence ID" value="ENSCJPP00005015828.1"/>
        <property type="gene ID" value="ENSCJPG00005013067.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107316799"/>
    <dbReference type="KEGG" id="cjo:107316799"/>
    <dbReference type="CTD" id="7520"/>
    <dbReference type="GeneTree" id="ENSGT00940000153239"/>
    <dbReference type="OrthoDB" id="30826at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070418">
        <property type="term" value="C:DNA-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005958">
        <property type="term" value="C:DNA-dependent protein kinase-DNA ligase 4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043564">
        <property type="term" value="C:Ku70:Ku80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032993">
        <property type="term" value="C:protein-DNA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090734">
        <property type="term" value="C:site of DNA damage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051575">
        <property type="term" value="F:5'-deoxyribose-5-phosphate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045027">
        <property type="term" value="F:DNA end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003691">
        <property type="term" value="F:double-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002218">
        <property type="term" value="P:activation of innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071480">
        <property type="term" value="P:cellular response to gamma radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990830">
        <property type="term" value="P:cellular response to leukemia inhibitory factor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060218">
        <property type="term" value="P:hematopoietic stem cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071425">
        <property type="term" value="P:hematopoietic stem cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904430">
        <property type="term" value="P:negative regulation of t-circle formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022008">
        <property type="term" value="P:neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050769">
        <property type="term" value="P:positive regulation of neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070198">
        <property type="term" value="P:protein localization to chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048660">
        <property type="term" value="P:regulation of smooth muscle cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034462">
        <property type="term" value="P:small-subunit processome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00873">
        <property type="entry name" value="KU80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1600.10:FF:000002">
        <property type="entry name" value="X-ray repair cross-complementing protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.240:FF:000001">
        <property type="entry name" value="X-ray repair cross-complementing protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.290.10:FF:000005">
        <property type="entry name" value="X-ray repair cross-complementing protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000055">
        <property type="entry name" value="X-ray repair cross-complementing protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.240">
        <property type="entry name" value="Ku, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006164">
        <property type="entry name" value="DNA_bd_Ku70/Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024193">
        <property type="entry name" value="Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005160">
        <property type="entry name" value="Ku_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036494">
        <property type="entry name" value="Ku_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005161">
        <property type="entry name" value="Ku_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014893">
        <property type="entry name" value="Ku_PK_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604">
        <property type="entry name" value="KU AUTOANTIGEN DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604:SF4">
        <property type="entry name" value="X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
        <property type="entry name" value="Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03730">
        <property type="entry name" value="Ku_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03731">
        <property type="entry name" value="Ku_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08785">
        <property type="entry name" value="Ku_PK_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016570">
        <property type="entry name" value="Ku80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00559">
        <property type="entry name" value="Ku78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101420">
        <property type="entry name" value="C-terminal domain of Ku80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SPOC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9 14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034611724" description="X-ray repair cross-complementing protein 5" evidence="16">
        <location>
            <begin position="21"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="domain" description="Ku" evidence="17">
        <location>
            <begin position="300"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="546"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="691"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="698"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="714"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00071961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR016570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="729" mass="82464" checksum="C63DFA630446FA69" modified="2022-01-19" version="1">MARGGKSAIVLCLDVGITMGSSAPGEESSLEQAKKVITKFLQRQVFAESKDEVAVVLFGTGGTKNDLASGDQYQNITVHRSLMLPDFDLLEDIQSTIRLDSQQADFLDAIIVCMDLLQKETLGKKFEKIHIELFTDLSSPVSEDQLEIIVANLKKTGISLQFFLPFPVDGADGRGDASASIYSQLHQSSLPRKGLTAQQKEGLDVVKKLMHTLDEKGGLEEIYTFRESMERLAMFKKIERRPIPWPCNLTIGSDLSIKIVAYKAITEEKVKKIWTVVDAKTLRKEDVQRETVYCLNDDDETEVQKDDTIQGFRYGSDIVPFSKEDEEQMKYKTEAKCFSVLGFSRSSQIQRHCYMGNQVLKVFAAKGDENAAVAFSALVQALDELNVVAIVRYAYDRRCNPQIGVAFPCIKDTYECLFYVQLPYMEDVRQYMFSSLKNNKKCTPTADQLSAIDSLIDSMNLVYEDDDGETFGDLFKPSKIPNPHFQRLYQCLQHKAFHPNEPLPPIEQHLLEMLEVPHVVKERCKGPLEKVKALFPLKDAGKKKEEKTAQDIFKDDEEGPNAKRRKIEDEEDSFSIMKLAEGNVTSVGSVNPAEDFKILVRQKNADFRDVSQQLINRIDQFLENRSSQYYMKGINCIRVFRAEAVKLSKVQCFNDFLQALKSKVEDKALADFWEIVVQDRISLITKDEAEGSSVTSEEAQKFLAPKEKNNETLPDTDEGGDVDDLLDMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TQZ7</accession>
    <name>A0A8C2TQZ7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="30">Histone-lysine N-methyltransferase ASH1L</fullName>
            <ecNumber evidence="4">2.1.1.359</ecNumber>
            <ecNumber evidence="29">2.1.1.367</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="31">ASH1-like protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="32">Absent small and homeotic disks protein 1 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="40" type="primary">ASH1L</name>
    </gene>
    <organism evidence="40 41">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="40" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="40" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="40" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="28">Histone methyltransferase specifically trimethylating 'Lys-36' of histone H3 forming H3K36me3. Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. The physiological significance of the H3K9me1 activity is unclear.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60324"/>
            <dbReference type="Rhea" id="RHEA-COMP:9785"/>
            <dbReference type="Rhea" id="RHEA-COMP:15536"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.359"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine = N(6)-methyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60280"/>
            <dbReference type="Rhea" id="RHEA-COMP:15542"/>
            <dbReference type="Rhea" id="RHEA-COMP:15546"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="EC" id="2.1.1.367"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell junction</location>
            <location evidence="3">Tight junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.359" evidence="4"/>
    <dbReference type="EC" id="2.1.1.367" evidence="29"/>
    <dbReference type="RefSeq" id="XP_015740056.1">
        <property type="nucleotide sequence ID" value="XM_015884570.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015740057.1">
        <property type="nucleotide sequence ID" value="XM_015884571.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015740058.1">
        <property type="nucleotide sequence ID" value="XM_015884572.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005024306.1">
        <property type="protein sequence ID" value="ENSCJPP00005017443.1"/>
        <property type="gene ID" value="ENSCJPG00005014237.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107324503"/>
    <dbReference type="KEGG" id="cjo:107324503"/>
    <dbReference type="CTD" id="55870"/>
    <dbReference type="GeneTree" id="ENSGT00940000156698"/>
    <dbReference type="OrthoDB" id="79252at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140955">
        <property type="term" value="F:histone H3K36 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042800">
        <property type="term" value="F:histone H3K4 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140948">
        <property type="term" value="F:histone H3K9 monomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030317">
        <property type="term" value="P:flagellated sperm motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000165">
        <property type="term" value="P:MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002674">
        <property type="term" value="P:negative regulation of acute inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007338">
        <property type="term" value="P:single fertilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001501">
        <property type="term" value="P:skeletal system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd04717">
        <property type="entry name" value="BAH_polybromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05525">
        <property type="entry name" value="Bromo_ASH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15548">
        <property type="entry name" value="PHD_ASH1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19174">
        <property type="entry name" value="SET_ASH1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000025">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.270.10:FF:000011">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.490:FF:000008">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000113">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        </source>
    </evidence>
    <sequence length="3032" mass="338536" checksum="49A2FC20CA24B8A5" modified="2022-01-19" version="1">MDPRNTAMLGLGSDSEGFSGKSPSLVNIGTLVGKGDVELESCTKEEEEGEKNREGNGVENGKKEALVDAQQQFSVKETNFSEGNLKLKIGLQAKRTKKPPKNLENYVCRPAIKTSIKQPRRPPKSGKMTDEKNEHCPSKQDPSKSYKKAGEVTTVELHVEEGIQVETNPLPKKVSPLHTEMTDYIKSSPPTLISSHNSDLKDRTQINGATTVTEKLAQLIATCPPSKSSKTKQKKPGSGTASGLVKDSGKKLPGTIPTSGIVNKDLVKKLPGSGIAVGLVSKDSGKKPLGIGSAAILVSKDSGKKPQGVGPLIGLVNKDSGKRLAGISTPPGLVSKDSGKKQPMTSSAVGLINKDVGRKFPGISTPTGLTNKESAKKPAGISTPAGLINKDAGKKLLGISSPAGLVSKDTGRKMPGTGNATALTNKDSGRKTPGIGSPVGPVNKDSGRKIVGISSPVGLVSKDSGKKPTGISTPVGLVNKDSGTLKADSLMPASEPFKLPCNSNLESHDATDLLKENTSSKTFEKHIVRQSKESILDKFSIRKEIADVGKEMFNEGICVPQDGYSASEKGVYETSKHEKQPPVYCTSPDFRTGGASDVSTAKSPFSAVGEGNLPSPSPTVSVTTLNRSLSAASSQLASNTLHLSSTADLLEGISDQIGKTQFSPDSTHLNINRTLNHALSTDFKGADKDLSESKATYVEPSRTSPSLGKKPILAAETSIHATVTPSVVSFTSLFSSKQFLKIGAIAASDKSCQGAKNLSTSQQSKPLKKRKGRKPRWTKVVSRSTCRPPKGLELERSELFKNISYSALSNSNLEQAKFLKNIGSSSFVEHEFVKHQLPKLNEGSGQSLALLTESDKQTPKFYSAHKQPSSLCMSDDFLPDMYKPKRGRPKSKEMPELEGPPKRTLKIPASKVFSVQSKEEQEPPILQPEVEIPSLKQSLSGQAFPKKRGRPKRQMRSSIKMKPPILSVAPFVGTESSNKIESESDQHRSGEFFERKDQLRGPEDVQKPNICSMSDLEGDSDRKVAKRNNGQLMKTIIRKINKMKTLKRKKLLNQILSSTVEPNKGKVQSKLHNTVSTLAATFGSKLGQQINVSKKGTIYIGKRRGRKPKAVLNGILTSNSASLTVLEKSSQQTPGTSFGQVLPHLLPSAANSSEILPSPVCSQSSAVSGGQSPVSSDAGFIEPSSVPYLHIHSRQGSVVQTLAMKKAAKGRRRLSPPTLLPNSPSHLSELTSLKEATPSPVSESHSDETIPSDSGIGTDNNSTSDRAEKFCGQKKKRHSFDHVSLIAPEASTVLSNLKEKHKHKCKRRSHDYLSYDKMKRQKRKRKKKYPQLRGRQDPDFLAELEELISRLSEIRITHRSHHFIPRDLLPTIFRINFNSFYTHPTFPLDPLHYIRKPDLKKKRGRPPKMREAMAEMPFMHSLSFPLSSTGFYPSYGMPYSPSPLAAAPIGLGYYGRYPPTLYPPPPSPSFTTPLPPPSYMHTGHLLLNPTKYHKKKHKLLRQEAFLTTSRTPLLSMSTYPSVPPEMAYGWMLEHKHRHRHKHREHRTSEQQQVSMDTITANSSSRTVLESLKRYRFGKEAVGERYKHKEKHRCHMSCPHLSPSKGLLSRDEQWVRREPSESNSLALGLQTPLQIDCSDSSPGLSLGGFTPSSEPASSDEHTNLFTSAIGSCRVTNSTSTNGRKKLTDSPGLFSAQDSSLNRPLRKEPLPSIEKALQPLSGALPTQDKPSQRQSESTNCSPSRKRSTSESTSSTVIGVPTRGTRLTAADDPVDSLLQRMAQHEGQAALDKSIEAVIANVSVPPSSSPARNHNRERSLGKQDSLVAPAIPSSSCSDSISLLSDRLPNSYSPHHLKRSVVEAMQRQARKMCNYNKILATKKNLDHVNKILKAKKLQRQSRTGNNFVKRRPGRPRKYPMQAVVSMQAFQAARLVSQELDKREESSSPLHLGPDTITDVIEAVVQSVNLNPDHQKGWKRKRWLSEEQARKRQKPLPEDEQESSKSFSEAPPEPPSPQDALGKPPEPENPQQQQQQQQQQQQPLPSLPQREKKAPRPPKKKYQKAGLYSDVYKTADPKSRLIQLKKEKLEYTPGEHEHGLFPAPIHVGKYLRQKRIDFQLPYDILWQWKHNQLYKKPDVPLYKKIRSNVYVDVKPLSGYEATTCNCKKPDDENGKGCMEDCLNRMIFAECSPNTCPCGEQCCNQRIQRHEWVQCLERFRAEEKGWGIRTKEPLKAGQFIIEYLGEVVSEQEFRNRMIEQYHNHSDHYCLNLDSGMVIDSYRMGNEARFINHSCNPNCEMQKWSVNGVYRIGLYALKDMPAGTELTYDYNFHSFNVEKQQLCKCGFEKCRGIIGGKSQRVNGLPNKNNQPVSSHRRTGRSKEKRKSKHKLKKRRGHMPEEPSESVNTPTRLTPQLQMKPMSNRERNFVLKHHVFLVRNWEKIRQKQEEVKQVSDNIHTASLYSRWNGICRDDGNIKSDVFMTQFSALQTARSVRTRRLAAAEENIEVARAARLAQIFKEICDSIIAYKGEDSSRQALAAPLLNLPPKKKNADYYEKISDPLDLATIEKQILTGYYKTVEAFDGDMLKVFRNAEKYYGRKSPTGRDVCRLRKAYYNARHEASAQIDEIVGETASEADSSETSVCEKENGHEKDEDVIRCICGLYKDEGLMIQCEKCMVWQHCDCMGVNSDVEHYLCEQCEPRSVNREVPMIPRPHYTQPGCVYYICLLRDELLLRQGDCVYLMRDSRRTPDGHPVRQSYRLLSHINREKLDIFRIEKLWKNEKEERFAFGHHYFRPHETHHSPSRKFYHNELFRVPLYEIIPLEAVVGTCCVLDLYTYCKGRPKGVKEQDVYICDYRLDKSAHLFYKIHRNRYPVCTKPYAFDHFPKKLTPKRDFSPHYVPDNYKRNGGRSSWKSDRAKQQIKDLNQEEESLPLMEDVLGNQEQAGSEAPSLEEPEKEAVPTETSETEKKAEEGTGDTQQLCSPEERRHIQRERLNQILLNLLEKIPGKNAIDVTYLLEEGSGRKLRRRTLTIPDSSFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TR66</accession>
    <name>A0A8C2TR66_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Noggin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the noggin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TR66"/>
    <dbReference type="Ensembl" id="ENSCJPT00005023317.1">
        <property type="protein sequence ID" value="ENSCJPP00005016607.1"/>
        <property type="gene ID" value="ENSCJPG00005013631.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000006009"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051216">
        <property type="term" value="P:cartilage development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009953">
        <property type="term" value="P:dorsal/ventral pattern formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030514">
        <property type="term" value="P:negative regulation of BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045596">
        <property type="term" value="P:negative regulation of cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001649">
        <property type="term" value="P:osteoblast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.520">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008717">
        <property type="entry name" value="Noggin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10494">
        <property type="entry name" value="BONE MORPHOGENETIC PROTEIN INHIBITOR, NOGGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10494:SF6">
        <property type="entry name" value="NOGGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05806">
        <property type="entry name" value="Noggin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008129">
        <property type="entry name" value="Noggin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0891">Chondrogenesis</keyword>
    <keyword evidence="3 7" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-0221">Differentiation</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034924598" description="Noggin" evidence="9">
        <location>
            <begin position="22"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="155"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="178"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="185"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="208"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR008129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR008129-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005016607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="237" mass="27036" checksum="BEDCB4709CB15E82" modified="2022-01-19" version="1">MQGPYCCLLLLLCLLPLLATGLEDPREPLPLPFSTSDPTAHLLRGRPSAPVRPYSLSLSPEDYRYAPKPRHLRPGRLRRLLGPAFDPFWMSSEEPLGRNLSAKEDLETMSRELAEGSGRYRRKLWREVEGMELPPELPVDMVRSLRRWLVERALCRLTSTWVDLGPVFWPRWVRHTACGTDPPSCSWPPGMACRPAQLTHLKLLAWHCWAARPPGPPQCAWRQIPYPVVVACKCSCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TRJ2</accession>
    <name>A0A8C2TRJ2_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Dishevelled segment polarity protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">DVL3</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DSH family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TRJ2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005023469.1">
        <property type="protein sequence ID" value="ENSCJPP00005016751.1"/>
        <property type="gene ID" value="ENSCJPG00005013742.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182903"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005109">
        <property type="term" value="F:frizzled binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002020">
        <property type="term" value="F:protease binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046330">
        <property type="term" value="P:positive regulation of JNK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032880">
        <property type="term" value="P:regulation of protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060071">
        <property type="term" value="P:Wnt signaling pathway, planar cell polarity pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd04438">
        <property type="entry name" value="DEP_dishevelled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06717">
        <property type="entry name" value="PDZ_Dishevelled-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.240.130:FF:000001">
        <property type="entry name" value="Segment polarity protein dishevelled homolog DVL-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000040">
        <property type="entry name" value="segment polarity protein dishevelled homolog DVL-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000014">
        <property type="entry name" value="Segment polarity protein dishevelled homolog DVL-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024580">
        <property type="entry name" value="Dishevelled_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008339">
        <property type="entry name" value="Dishevelled_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003351">
        <property type="entry name" value="Dishevelled_protein_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001158">
        <property type="entry name" value="DIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038207">
        <property type="entry name" value="DIX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015506">
        <property type="entry name" value="Dsh/Dvl-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
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        <property type="entry name" value="Ubiquitin-like_domsf"/>
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        <property type="entry name" value="SEGMENT POLARITY PROTEIN DISHEVELLED"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR10878:SF6">
        <property type="entry name" value="SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-3"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DEP"/>
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        <property type="entry name" value="Dishevelled"/>
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        <property type="entry name" value="DIX"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Dsh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DISHEVELLED"/>
    </dbReference>
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        <property type="entry name" value="DISHEVELLED1"/>
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        <property type="entry name" value="DAX"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Winged helix' DNA-binding domain"/>
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        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PDZ"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0879">Wnt signaling pathway</keyword>
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        <location>
            <begin position="227"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="8">
        <location>
            <begin position="472"/>
            <end position="544"/>
        </location>
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            <begin position="662"/>
            <end position="736"/>
        </location>
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            <end position="235"/>
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    <feature type="region of interest" description="Disordered" evidence="7">
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    <feature type="region of interest" description="Disordered" evidence="7">
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            <begin position="749"/>
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    <feature type="region of interest" description="Disordered" evidence="7">
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            <begin position="785"/>
            <end position="925"/>
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    <feature type="compositionally biased region" description="Gly residues" evidence="7">
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            <begin position="163"/>
            <end position="173"/>
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    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="195"/>
            <end position="207"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
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            <begin position="365"/>
            <end position="379"/>
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            <begin position="397"/>
            <end position="413"/>
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        <location>
            <begin position="422"/>
            <end position="435"/>
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            <begin position="436"/>
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        <location>
            <begin position="805"/>
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        <location>
            <begin position="821"/>
            <end position="833"/>
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        <location>
            <begin position="842"/>
            <end position="858"/>
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        <location>
            <begin position="863"/>
            <end position="875"/>
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    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="891"/>
            <end position="917"/>
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            <dbReference type="ARBA" id="ARBA00004496"/>
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            <dbReference type="ARBA" id="ARBA00008735"/>
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            <dbReference type="Proteomes" id="UP000694412"/>
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    <sequence length="951" mass="102250" checksum="FB2ABBBF2408D682" modified="2022-01-19" version="1">MRTLCCGMGSRCMGVTVYGGSRCMGVTVYGVTVYGGSRCMGSWCMGGHGVWGVRWGSVWGSRCMGGHGVMGHALYGGHGVWGVTVYGGVHPCMGITVYGVTVYGVMVYAARCGDPVRAVPRAAQQRGPVGRRFRFRWGRGGGGAAGRSVRGASGRRWDPQNKGRGGSGAGGPEPGRARTAREPGPGRAERDRGGRAAGGGAGGLGPGRGRRSGGPAAGQGRHGGGRDGRSSTTWTSRKDAVLVKLPIPAERVTLGDFKGLLNRPNYKFYFKSMDDDFGVVKEEISDDNAKLPCFNGRVVSWLVSAEGSHSDAGSVCADNQTELPPSMERTGGIGDSRPPSFHPNTGGSRENLDNETETDSVVSSQRERPRRKDGPEHAPRVNGTVKGERRRDLGGYESSSTLMSSELETTSFFDSDEDDSTSRFSSSTEQSSASRLMRRHKRRRRKQKAPRIERSSSFSSITDSTMSLNIITVTLNMEKYNFLGISIVGQSNERGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDINFENMSNDDAVRVLREIVHKPGPITLTVAKCWDPSPRGCFSLPRIAPQRIWAGPDSPCSDPGEPIRPIDPAAWVSHTAAMTGTYPAYGMSPSMSTITSTSSSITSSIPETERLDDFHLSIHSDMATIVKAMASPESGLEVRDRMWLKITIPNAFIGSDVVDWLYHHVEGFTDRRESRKYASNLLKAGYIRHTVNKITFSEQCYYIFGDLCGNMANLSLHDHDGSSGASDQDTLAPLPHPGAAPWPMAFPYQYPPPHPYNPHPGFPDPSYSYGGGSAGSQHSEGSRSSGSNRSGSERRKEREKTGESKSGGSGSESDHTTRSSMRRERAASERSVPASQHSQRSQHSLAHSIRSHHSQQSYGPPGLPPLFSPPMLLMPPPPSAMGPPGAPPGRDLASVPPELTASRQSFRMAMGNPSEFFVDVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TRK6</accession>
    <name>A0A8C2TRK6_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Neuronal growth regulator 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">NEGR1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the immunoglobulin superfamily. IgLON family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TRK6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005024863.1">
        <property type="protein sequence ID" value="ENSCJPP00005017881.1"/>
        <property type="gene ID" value="ENSCJPG00005014529.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159289"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042632">
        <property type="term" value="P:cholesterol homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045444">
        <property type="term" value="P:fat cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007631">
        <property type="term" value="P:feeding behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140042">
        <property type="term" value="P:lipid droplet formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007626">
        <property type="term" value="P:locomotory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048812">
        <property type="term" value="P:neuron projection morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050850">
        <property type="term" value="P:positive regulation of calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010976">
        <property type="term" value="P:positive regulation of neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046878">
        <property type="term" value="P:positive regulation of saliva secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060538">
        <property type="term" value="P:skeletal muscle organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035176">
        <property type="term" value="P:social behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="cell adhesion molecule 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000305">
        <property type="entry name" value="neurotrimin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000113">
        <property type="entry name" value="Opioid-binding protein/cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
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        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050876">
        <property type="entry name" value="IgLON_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42757">
        <property type="entry name" value="IGLON FAMILY OF IMMUNOGLOBULIN SUPERFAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42757:SF6">
        <property type="entry name" value="NEURONAL GROWTH REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="11" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="86"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="196"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="282"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00041100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005017881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="425" mass="45331" checksum="AADCA408F7352CEB" modified="2022-01-19" version="1">MATGCQPGGRPPPRRAELRAQSGRRCPPGRCCGGRPGAATRRARPPTAGSPGAARSGAEMVPLVRGAGGSHQWLAAVLLGLCCLLPAGRLAAPGGDFHGAAADSLVVRKGDTAVLRCYLEDGASKGAWLNRSSIIFAGSDKWSVDPRVSIATANRREYSLQIQDVDVTDDGPYTCSVQTQHTPRTMQVHLTVQVSPKIFRISSDIVVNEGSNVTLVCLATGKPEPSISWRHISPSAKPFESGQYLDIYGITRDQAGEYECSAENDVSVPDVKKVKVTVNFAPTIQELKSSGVMLGGNGLIRCEGAGVPAPVFEWYRGERKLISGQQGITIKNYSTRSLLTVTNVTEEHFGNYTCVAVNKLGMTNASLPLNQIIEPTTSSPVSSPAPSTAQYGITGDAEVLFSCWYLVLTLSSLTSIFYLKNIILH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TRL8</accession>
    <name>A0A8C2TRL8_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Transmembrane and coiled-coil domains 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">TMCO3</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TRL8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005023364.1">
        <property type="protein sequence ID" value="ENSCJPP00005016652.1"/>
        <property type="gene ID" value="ENSCJPG00005013645.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000001394"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045158">
        <property type="entry name" value="KEA4/5/6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16254">
        <property type="entry name" value="POTASSIUM/PROTON ANTIPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16254:SF14">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0050">Antiport</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034088989" evidence="12">
        <location>
            <begin position="24"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="437"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="482"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="538"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="563"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="625"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="13">
        <location>
            <begin position="264"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="126"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005016652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="661" mass="73886" checksum="4A6F90479398DBF9" modified="2022-01-19" version="1">MKVPGFISLWTLTSLLCGQLGNTAEHEDVVKHAIKLHRGKGAVITQRKQWVMESCRKLSGLLRQKNVVLNKLKSAIRAVEKDAGLSDEEKLFQVHTFEIFQKELNESENSVFQAIHGLQRALQGDYKDVVNMKESSRQRLEALREAAIKEEMEYVELLAAEKHQVEALKNMQHQNKSLSMLDEILEDVRKAADRLEEEIEEHAFDDNKSVRGVNFEAVFKGEEDEANSKRNASKREVEDDLAQDSTIPRADHHFIKDIVTIGMLSLPCGWLCTMIGLPTMFGYIICGVLLGPSGLNSIKSIVQVETLGEFGVFFTLFLVGLEFSPERLRKVWKISLQGPCYMTVLMIAFGLLWGHLLQIRPTQSVFISTCLSLSSTPLVSRFLAGTVRGDKEGDIDYSSVLLGMLVMQDVQLGLFIAVMPTLIQAGVSTHSSIFKEILRILILIGQILFSLAAVFLICLVIKTYLIGPYYRKLHAESKGNKEILILGISAFIFLMLTITELLDVSMELGCFLAGALISSQGHMITEEIMACIEPIRDFLAIIFFASIGLHVFPTFVIYELTVLLFLTLSVVIMKFVLAVLVLSLILPKTSQYIKWIVSAGLAQVSEFSFVLGSRARRAGIISREVYLLILSVTTLSLLLAPALWRAAIMKCVPRPERRSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TS12</accession>
    <name>A0A8C2TS12_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Osteocrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">OSTN</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015727417.1">
        <property type="nucleotide sequence ID" value="XM_015871931.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TS12"/>
    <dbReference type="Ensembl" id="ENSCJPT00005023210.1">
        <property type="protein sequence ID" value="ENSCJPP00005016526.1"/>
        <property type="gene ID" value="ENSCJPG00005013565.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107318282"/>
    <dbReference type="CTD" id="344901"/>
    <dbReference type="GeneTree" id="ENSGT00390000001750"/>
    <dbReference type="OrthoDB" id="9900165at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006182">
        <property type="term" value="P:cGMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003416">
        <property type="term" value="P:endochondral bone growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046325">
        <property type="term" value="P:negative regulation of D-glucose import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903860">
        <property type="term" value="P:negative regulation of dendrite extension"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045668">
        <property type="term" value="P:negative regulation of osteoblast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008217">
        <property type="term" value="P:regulation of blood pressure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021088">
        <property type="entry name" value="Osteocrin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35353">
        <property type="entry name" value="OSTEOCRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35353:SF1">
        <property type="entry name" value="OSTEOCRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11037">
        <property type="entry name" value="Musclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034297226" evidence="1">
        <location>
            <begin position="31"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005016526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="133" mass="14322" checksum="7B0BCEECDD754882" modified="2022-01-19" version="1">MLQFQLVVVHLALVITLLQWHSSSVLLAEAAPEPLEPSAALGMAVHPTASEEKSASSLAAKLLLLDELVSLENEVTETKKKRSFPGFGSPIDRISATSVDAKGKQRKVVELPKRRFGVPLDRIGVSRLGNTKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TS19</accession>
    <name>A0A8C2TS19_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">cAMP responsive element binding protein 3 like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">CREB3L1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the bZIP family. ATF subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TS19"/>
    <dbReference type="Ensembl" id="ENSCJPT00005023734.1">
        <property type="protein sequence ID" value="ENSCJPP00005016955.1"/>
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        <property type="entry name" value="LEUZIPPRCREB"/>
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        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0834">Unfolded protein response</keyword>
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        <location>
            <begin position="284"/>
            <end position="347"/>
        </location>
    </feature>
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            <end position="100"/>
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    <feature type="region of interest" description="Disordered" evidence="10">
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            <end position="494"/>
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            <end position="99"/>
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            <end position="243"/>
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            <end position="474"/>
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    <sequence length="494" mass="54649" checksum="4882CDF2DA391E33" modified="2022-01-19" version="1">MDSILEPFAAERLFPAAGPGFLDLGDFSEADFLSNVHFSENLDHFSDNMEDFSNDLFSSFFDDPVLAEKNPLLDMDLDPPTPGIQAEHSYSLSGDSAPQSPLMPVKTEDNANELENGVWALGPKLCSIMVKQEQNLALDPPESQLAASSRPVLNLNPLQRLPVPEETPIEMTPAPVIKAEPKEVNQFLNVPADDLVQMPPTPPSSHGSDSDGSQSPRSLPPSSPARPAARSSTAISSSPLLTAPHKLQGTSGPLLLTEEEKRTLVAEGYPIPTKLPLTKAEEKALKRVRRKIKNKISAQESRRKKKEYVECLEKKVETYTTENNELWKKVETLESANRTLLQQLQKLQALVAGKVSRPYKMASTQTGTCLMVLVLCFVLILGSLMPCLPEFSTSSQTVKATPAPDIYTTSKIQSRSLLFYDEGAGSLEESYSSFLTMDHPEGWEAEKGQSDEPRPHLARTHETAKYMSKSHLENPDQNQTDPTLTHFKEQFHER</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TSI7</accession>
    <name>A0A8C2TSI7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Epidermal growth factor receptor kinase substrate 8-like protein 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Epidermal growth factor receptor pathway substrate 8-related protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">EPS8L2</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. In the cochlea, is required for stereocilia maintenance in adult hair cells.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with ABI1. Part of a complex that contains SOS1, ABI1 and EPS8L2. Associates with F-actin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EPS8 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_032300584.1">
        <property type="nucleotide sequence ID" value="XM_032444693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TSI7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005023134.1">
        <property type="protein sequence ID" value="ENSCJPP00005016455.1"/>
        <property type="gene ID" value="ENSCJPG00005013525.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107314161"/>
    <dbReference type="KEGG" id="cjo:107314161"/>
    <dbReference type="CTD" id="64787"/>
    <dbReference type="GeneTree" id="ENSGT00940000160990"/>
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        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032587">
        <property type="term" value="C:ruffle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032426">
        <property type="term" value="C:stereocilium tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031982">
        <property type="term" value="C:vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900029">
        <property type="term" value="P:positive regulation of ruffle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035023">
        <property type="term" value="P:regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007605">
        <property type="term" value="P:sensory perception of sound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="PTB_EPS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09540">
        <property type="entry name" value="SAM_EPS8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11764">
        <property type="entry name" value="SH3_Eps8"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Epidermal growth factor receptor kinase substrate 8"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="epidermal growth factor receptor kinase substrate 8-like protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039801">
        <property type="entry name" value="EPS8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055093">
        <property type="entry name" value="EPS8_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033928">
        <property type="entry name" value="EPS8_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035462">
        <property type="entry name" value="Eps8_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013625">
        <property type="entry name" value="PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041418">
        <property type="entry name" value="SAM_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12287:SF20">
        <property type="entry name" value="EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE 8-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12287">
        <property type="entry name" value="EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE EPS8-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22975">
        <property type="entry name" value="EPS8_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08416">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18016">
        <property type="entry name" value="SAM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="14">
        <location>
            <begin position="496"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="188"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="564"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="233"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00057110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00065375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00077702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005016455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="736" mass="83855" checksum="300D6AC1B2F1395A" modified="2022-01-19" version="1">MSLKGSLSSSPGSTNGSMGKADGASKLSAKDLYEQRKKYSNSNIIMHETSQYHVQHLATFIMDKSESIVTVDDAIRKLLLLNSKEKIWTQEMLLQVNDKSIRLLDCESQEELEDFPLPTVQHCQTVLNQMRYSSILLLVCQDSEQHKPDIHFFNCDEVEAEMVHEDIESALADHKHGKKIRPQTLKANQEKIKQRQSILPPPQGPAPIPFQHDMRGQGMNRNRVAPPAQYEPDYERRGSASQDHEESRAILAQKIEKETQILNCTLDDIEVFVARLQKAAEAFKQLNQRKKGKKNKKKGPAEGMLTLRARPPSEAEFIDCFQKTKLAFNLLAKLRKHIQNPSASELVHFLFGPLELIVNSCGGPELARSVISPLLSKDATDFLRGHLTPKEISLWDSLGEAWTRSRAEWPREANIPTYIPKFRNGWEPPIEIFRGAPWEIDIGHLQEELSSANGYPYRNSSLKRGQTADQTQAVDAFKQNVTQHVNRNFEAQGMAQPKRYAKIRYDFTARNANELSVLKDEILEVLEDNKQWWKLLNRSGQAGYVPYNILDVVKLEELEQANQRYKGDPSPRGYGPSSPTHKLPASYAGDKWGSEMLSRNSPQDAKEQLLHQMDEVNDELLKKITNSKIQPPQRNFRVEKPQEVYVPLTFESSAEEVKAWLEAKSFSKGTVDHLGILTGAQLFSLNREELKKVCGDEGNRVYSKITVEKNQLEKNRGETELQEIMKRRQERIDSAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TTR8</accession>
    <name>A0A8C2TTR8_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TTR8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005026077.1">
        <property type="protein sequence ID" value="ENSCJPP00005018805.1"/>
        <property type="gene ID" value="ENSCJPG00005015273.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00960000189065"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005018805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="181" mass="19412" checksum="96E4727860BD2292" modified="2022-01-19" version="1">VTSCPPPSCPCPPWRPVRPTTPWRSGWPRCWGPPRAGSPTRSAGTRGPASRRSHPPPPSPWWARRCPWPCCCPHRPHPPAICSSSVMLLRSGSPARPNSCWVMVIFSRASSESMGTTATLTAWPGANSAALAQTAHTASRTQPPSLDTPPLPNPDGEFQCEPREAPAWSCSHPAPTSCSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TUM3</accession>
    <name>A0A8C2TUM3_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="15">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">SIAH1</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 15">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">The RING-type zinc finger domain is essential for ubiquitin ligase activity.</text>
    </comment>
    <comment type="domain">
        <text evidence="15">The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 15">Belongs to the SINA (Seven in absentia) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="15"/>
    <dbReference type="RefSeq" id="XP_015729402.1">
        <property type="nucleotide sequence ID" value="XM_015873916.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015729403.1">
        <property type="nucleotide sequence ID" value="XM_015873917.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032302887.1">
        <property type="nucleotide sequence ID" value="XM_032446996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TUM3"/>
    <dbReference type="SMR" id="A0A8C2TUM3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005024565.1">
        <property type="protein sequence ID" value="ENSCJPP00005017630.1"/>
        <property type="gene ID" value="ENSCJPG00005014369.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107319235"/>
    <dbReference type="KEGG" id="cjo:107319235"/>
    <dbReference type="CTD" id="6477"/>
    <dbReference type="GeneTree" id="ENSGT00940000154837"/>
    <dbReference type="OrthoDB" id="941555at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030877">
        <property type="term" value="C:beta-catenin destruction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001244">
        <property type="term" value="P:positive regulation of intrinsic apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03829">
        <property type="entry name" value="Sina"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.210.10:FF:000002">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000665">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000050">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000063">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018121">
        <property type="entry name" value="7-in-absentia-prot_TRAF-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004162">
        <property type="entry name" value="SINA-like_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049548">
        <property type="entry name" value="Sina-like_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013010">
        <property type="entry name" value="Znf_SIAH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45877:SF7">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SIAH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45877">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SIAH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21362">
        <property type="entry name" value="Sina_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03145">
        <property type="entry name" value="Sina_TRAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21361">
        <property type="entry name" value="Sina_ZnF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51081">
        <property type="entry name" value="ZF_SIAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="11 15" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="12 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 14 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="17">
        <location>
            <begin position="41"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="SIAH-type" evidence="18">
        <location>
            <begin position="93"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU201113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005017630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="282" mass="31127" checksum="FA07CC94DC1973D5" modified="2022-01-19" version="1">MSRQTATALPTGTSKCTPSQRVPALTGTTASNNDLASLFECPVCFDYVLPPILQCQSGHLVCSNCRPKLTCCPTCRGPLGSIRNLAMEKVANSVLFPCKYASSGCEITLPHTEKADHEELCEFRPYSCPCPGASCKWQGSLDAVMPHLMHQHKSITTLQGEDIVFLATDINLPGAVDWVMMQSCFGFHFMLVLEKQEKYDGHQQFFAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATPRSIHEGIATAIMNSDCLVFDTSIAQLFAENGNLGINVTISMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TV17</accession>
    <name>A0A8C2TV17_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Zinc finger protein 687</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ZNF687</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015740158.1">
        <property type="nucleotide sequence ID" value="XM_015884672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TV17"/>
    <dbReference type="Ensembl" id="ENSCJPT00005026080.1">
        <property type="protein sequence ID" value="ENSCJPP00005018808.1"/>
        <property type="gene ID" value="ENSCJPG00005015276.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107324562"/>
    <dbReference type="KEGG" id="cjo:107324562"/>
    <dbReference type="CTD" id="57592"/>
    <dbReference type="GeneTree" id="ENSGT00940000156524"/>
    <dbReference type="OrthoDB" id="7312725at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001571">
        <property type="entry name" value="Zinc finger protein 687"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002443">
        <property type="entry name" value="Zinc finger protein 687"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002453">
        <property type="entry name" value="Zinc finger protein 687"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002678">
        <property type="entry name" value="Zinc finger protein 687"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045914">
        <property type="entry name" value="Zn532-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041697">
        <property type="entry name" value="Znf-C2H2_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057356">
        <property type="entry name" value="Znf-C2H2_ZNF592"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47222">
        <property type="entry name" value="ZINC FINGER PROTEIN 532-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47222:SF2">
        <property type="entry name" value="ZINC FINGER PROTEIN 687"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16622">
        <property type="entry name" value="zf-C2H2_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25412">
        <property type="entry name" value="zf-C2H2_ZNF592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="586"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="746"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="805"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="868"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="899"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="1023"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="1141"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="1170"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="1222"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="156"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="254"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="375"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="939"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1104"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1196"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="213"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="257"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="308"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="334"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="375"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="974"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1114"/>
            <end position="1124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005018808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1259" mass="136909" checksum="0A5FC228BE771BC0" modified="2022-01-19" version="1">MGDMKTPDFDDLLAAFDIPDIDTNEAIHSGHDEAEAHIKPVPGEPGPPDHVLPHTDITAVSVIVKNTVCPEQLDTLDGRSKDGHGLGSRLLQNGFGAAELPRSPAARSVEAVASSNGECWVKEKGPKPLDIFSHFSPDPNEDNAANLIDRARECKPKDKSLAVPSLSPSPTPSLDCKEPRGESMEGLPPTFPQPFEGSQAGAVSGQPPAVPCIKKEESDSEEVARESNPKALSAALGESPLEHLKSVTVRYSAGDSPITSWPVSDPSLGSSASNLPEVKRSPSSPREPFFKPSSPVVQSPRIPPSPKQMDDVTLKEEREALEKSMGSPQSMSSAEEEEEEEEEEGNNNDSPSSNSSRPLKVRIKTIKTSCGSITRTVTRVSSDSEPGSAKGSAEQSCEDAALEAEKEDSIALEVPQEKMDLSSPLKAIEGPKIVSVQLGNGTKIKGTVLPVSTIQSASSAMLIAASVAQQKSVVLPAKTGKAVTKNIINLVPQALPKADTRTNASPVTQTSAVTTTANQKLNGTTVVMVQPQKPSPTVAGTVISRSQSSLVEAFNKILNSKNLLPTYKPNLSPPADASLALPPFGYRCLECGDSFALEKSLARHYDRRSMRIEVTCNHCTKRLVFFNKCSLLLHAREHKDKGLVMQCSHLVMRPIALDQMIGQPDITPLVSVASFPAGKVAGVTQDALSAANGAPELPILPLSSSGSEQSNYSCFRCLECKEQCKDKAGLAAHFQQVVASGTTSSTVCTTCPMIMSNRCSFSAHQRMHKNHPPHVCPECGGNFLLANFETHLKESCLHFSRRVGYRCPSCSVVFGGVNSIKSHIQTSHCEVFHKCPICPMAFKSAPSAHAHVYTQHPGFGNQQSKMIYKCAMCDTVFTHKPLLSSHFDQHLLNQRVSVFKCPDCPLLFAQKRTMLEHLKNTHQPPKPREEPAKKAALLLTPKQEPMETPVPKISDESSSSTEEDDPPSSPELRKAKRSRFQRKATSKSKGSGWTCGVCHSWFPERDEYVSHMKKDHGKSVKKFPCHLCERSFCSAPSLRRHVRVNHEGIKRVYPCRFCTEGKRTFSSRLILEKHIQVRHGIKVTDQTKSQEVIIARIGAGAMQVPGRKRKLSSDDGDSCSEEPDSTTPPSKTPKGDRKVPFRCRKCGYVASSAADFQEHIPQHRTDESSHQCRECGLCFTSQVSLNRHRFITHKKKKGAAEVEEPGPRSPMEGAPHAADGALSCTVCGRSFDSQLNLKTHFRTHGMAFIRARQNASPEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TVE3</accession>
    <name>A0A8C2TVE3_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Forkhead box C1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">FOXC1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TVE3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005026667.1">
        <property type="protein sequence ID" value="ENSCJPP00005019219.1"/>
        <property type="gene ID" value="ENSCJPG00005015623.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162303"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000792">
        <property type="term" value="C:heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008301">
        <property type="term" value="F:DNA binding, bending"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990841">
        <property type="term" value="F:promoter-specific chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061629">
        <property type="term" value="F:RNA polymerase II-specific DNA-binding transcription factor binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003275">
        <property type="term" value="P:apoptotic process involved in outflow tract morphogenesis"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:artery morphogenesis"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097746">
        <property type="term" value="P:blood vessel diameter maintenance"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0001974">
        <property type="term" value="P:blood vessel remodeling"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043010">
        <property type="term" value="P:camera-type eye development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060038">
        <property type="term" value="P:cardiac muscle cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071364">
        <property type="term" value="P:cellular response to epidermal growth factor stimulus"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021549">
        <property type="term" value="P:cerebellum development"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0070098">
        <property type="term" value="P:chemokine-mediated signaling pathway"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0030199">
        <property type="term" value="P:collagen fibril organization"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035050">
        <property type="term" value="P:embryonic heart tube development"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0001958">
        <property type="term" value="P:endochondral ossification"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008354">
        <property type="term" value="P:germ cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0072010">
        <property type="term" value="P:glomerular epithelium development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030203">
        <property type="term" value="P:glycosaminoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032808">
        <property type="term" value="P:lacrimal gland development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001945">
        <property type="term" value="P:lymph vessel development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036438">
        <property type="term" value="P:maintenance of lens transparency"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014031">
        <property type="term" value="P:mesenchymal cell development"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016525">
        <property type="term" value="P:negative regulation of angiogenesis"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902257">
        <property type="term" value="P:negative regulation of apoptotic process involved in outflow tract morphogenesis"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:1901491">
        <property type="term" value="P:negative regulation of lymphangiogenesis"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0045930">
        <property type="term" value="P:negative regulation of mitotic cell cycle"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014032">
        <property type="term" value="P:neural crest cell development"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0001541">
        <property type="term" value="P:ovarian follicle development"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048341">
        <property type="term" value="P:paraxial mesoderm formation"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:positive regulation of epithelial to mesenchymal transition"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:1902038">
        <property type="term" value="P:positive regulation of hematopoietic stem cell differentiation"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0045618">
        <property type="term" value="P:positive regulation of keratinocyte differentiation"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0046620">
        <property type="term" value="P:regulation of organ growth"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0001756">
        <property type="term" value="P:somitogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0001657">
        <property type="term" value="P:ureteric bud development"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048010">
        <property type="term" value="P:vascular endothelial growth factor receptor signaling pathway"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0038084">
        <property type="term" value="P:vascular endothelial growth factor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0055010">
        <property type="term" value="P:ventricular cardiac muscle tissue morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd20044">
        <property type="entry name" value="FH_FOXC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000016">
        <property type="entry name" value="Forkhead box protein I1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050211">
        <property type="entry name" value="FOX_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047391">
        <property type="entry name" value="FOXC1/C2-like_FH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829">
        <property type="entry name" value="FORKHEAD BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829:SF68">
        <property type="entry name" value="FORKHEAD BOX PROTEIN C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="9">
        <location>
            <begin position="38"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="7">
        <location>
            <begin position="38"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="133"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="357"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="470"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="194"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="250"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="379"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="472"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023015"/>
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            <dbReference type="ARBA" id="ARBA00023125"/>
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            <dbReference type="ARBA" id="ARBA00023163"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
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    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005019219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="519" mass="52423" checksum="5E74C87C55674A27" modified="2022-01-19" version="1">MPAPMSVYSHPAHEQYPGGMARAYGPYTPPPQPKDMVKPPYSYIALITMAIQNAPEKKITLSGIYQFIMDRFPFYRENKQGWQNSIRHNLSLNECFVKVPRDDKKPGKGSYWTLDPDSYNMFENGSFLRRRRRFKKKDAVKDKEEKDRLHLKDHAPPPPRPPPTAATGAEPEGGGPPAAGAAPPPVRIQDIKTENGTASPPQAVSPQGAAPPLGAVPKIESPDSSSSLSSGGSPRGGALPAARSLGMEGPEPPPPPPPPPPPPPPPHHHGPGFSVDNIMTSLRGSPQAAELGAGLLPPAAAAPRSSLPPALSLGAYSPGHSSAVYGSPCGQPAAAAAGSYHCNMQAMSLYAAAGGNERPGGHLPAASPAEEPLPDYAMPGGGGGGAANGGAGSGGGPGGGGGAGGGHQEGHHPHPHPHQGRLASWYLNQAAAAAAAAAAAAGELGYAGPQQSFAAGPRDVFEAPRMGLSASPGGGGGGGNAGSGGGGGAGGGGSCQMAFPGSQPLYRASGAFVYDCGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TVR7</accession>
    <name>A0A8C2TVR7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="28">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="28">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="33" type="primary">ATP11A</name>
    </gene>
    <organism evidence="33 34">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="33" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="33" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="33" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21 28">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38567"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:38568"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 27">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="24">Component of a P4-ATPase flippase complex which consists of a catalytic alpha subunit ATP11A and an accessory beta subunit TMEM30A.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Early endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="28">Membrane</location>
            <topology evidence="28">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Recycling endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 28">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="28"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2TVR7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005026835.1">
        <property type="protein sequence ID" value="ENSCJPP00005019363.1"/>
        <property type="gene ID" value="ENSCJPG00005015706.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157849"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
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    <sequence length="1164" mass="133435" checksum="D57832309F2EE5D9" modified="2022-01-19" version="1">VNCICCAGEENWVDSRTIYVGHREPPPGTEAYIPQRFPDNRIVSSKYTFWNFIPKNLFEQFRRIANFYFLIIFLVQLIIDTPTSPVTSGLPLLFVITVTAIKQGYEDWLRHKADNAMNQCPVHFIQHGKLVRKQSRKLRVGDIVMVKEDETFPCDLIFLSSSRGDGTCFVTTASLDGESSHKTHYAVQDTKAFHSEQEIDALHATIECEQPQPDLYKFVGRINVYHDRNEPTARPLGSENLLLRGATLKNTEKIFGVAIYTGMETKMALNYQSKSQKRSAVEKSMNVFLIVYLCILISKALINTVLKYVWQSEPFRDEPWYNQKTEPERKRNQFLQAFTDFLAFMVLFNYIIPVSMYVTVEMQKFLGSYFLTWDEEMFDEDTGEGPLVNTSDLNEELGQIEYVFTDKTGTLTENNMEFVECCIEGHVYIPHVICNGQILHDCTGIDMIDSSPGGSGKEREELFFRALCLCHTVQVKDDDSVDGLKKSQLSRRSRIYISSSPDEVALVEGIQRLGYTYLCLKDNYMEILNRENNREKFELLEVLSFDSVRRRMSVIVKSSTGDIFLFCKGADSSIFPRVKEGKIDQIRSRVERNAVEGLRTLCVAYKKLTAEEYSNAQKMLQNAKMALQDREKKLAEVYEKIETDFILLGATAVEDRLQEKAADTIEALQKAGIKVWVLTGDKMETAAATCYACKLFRRNTQILELTTKKIEEQSLHDVLFDLSKTVLRHSGSLTRDSFSGLSADMQDYGLIIDGAALSLIMKPRQDGSSGNYRELFLEICRNCSAVLCCRMAPLQKAQIVKLIKLSKEHPITLAIGDGANDVSMILEAHVGIGIIGKEGRQAARNSDYAIPKFKHLKKMLLVHGHFYYVRISELVQYFFYKNVCFIFPQFLYQFFCGFSQQPLYDTAYLTLYNISFTSLPILLYSLMEQHVSADTLKREPSLYRDVAKNALLRWRAFIYWTFLGVFDAVVFFFGAYFLFDNTIVTSNGQMFGNWTFGTLVFTVLVFTVTLKLALDTHYWTWINHFMIWGSLLFYIVFSLLWGGIIWPFLNYQRMYYVFMQMLSSGPAWLGIILLITVSLLPDVLKKVLCRQLWPTATERIQVTIFFRVIRNTGPAVLPGALQSTAPCADTWHHIKGRSCIQNMLSSAGSPWYLVVVQFKNFKWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TVS0</accession>
    <name>A0A8C2TVS0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Protein tweety homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">TTYH3</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Probable chloride channel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the tweety family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TVS0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005024256.1">
        <property type="protein sequence ID" value="ENSCJPP00005017400.1"/>
        <property type="gene ID" value="ENSCJPG00005014176.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183060"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005229">
        <property type="term" value="F:intracellularly calcium-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072320">
        <property type="term" value="F:volume-sensitive chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015813">
        <property type="term" value="P:L-glutamate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd07912">
        <property type="entry name" value="Tweety_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006990">
        <property type="entry name" value="Tweety"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12424:SF4">
        <property type="entry name" value="PROTEIN TWEETY HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12424">
        <property type="entry name" value="TWEETY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04906">
        <property type="entry name" value="Tweety"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11 13" id="KW-0868">Chloride</keyword>
    <keyword evidence="9 13" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="42"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005017400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="551" mass="61279" checksum="516A0DFDC601AFF6" modified="2022-01-19" version="1">MAGVSYSPPWWVSLLHRLPHLSLRWELTAADFRPDDAEYQQALLLLGGIALSCLALDLLFLLFYSFWLCCRHRKSEEHLNADCCCTAWCVIIATLVCSAGIAVGFYGNGETSDGIHRLTYSLRHANRTVAGVQDRVLDTTVALNQTAEPNLLILEEMFAKQTDHLHVIQKLQSLLDDLVRQTTEIPFWKNEELSLEELAIQIDLYDWYRWLGYLGLLLFHVLICLLVLFGLIRNSRAILMGVCLLGVFALIVSWGSLGLELAVAVGSSDFCINPDAYISKVVEENAVLSADTLRYYMTCSAGYPNPFQQKLSGSHKALVEMQDDVMELMRSASREHPTSKEYLARVQEVLNSTEINLQQLTALVDCRSLHLVSTHTDYSGVSNLWVLGGTSFPSCRSSDDDGEEESAAQGSRQTHDNLYRVHMPSLYSCGSSYGSETSIPAAAHTVSNAPVTEYMSQNANFQNPRCENTPLIGRESPPPSVSLSLLLLSASATLGNTHLPPLYILKGADCAVRHRIWPINQSSSRRATSHLPRRAKLNYATFDVAHKNIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TWE5</accession>
    <name>A0A8C2TWE5_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Adhesion G protein-coupled receptor A2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">ADGRA2</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSCJPT00005025932.1">
        <property type="protein sequence ID" value="ENSCJPP00005018668.1"/>
        <property type="gene ID" value="ENSCJPG00005015189.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158941"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990909">
        <property type="term" value="C:Wnt signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007417">
        <property type="term" value="P:central nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043542">
        <property type="term" value="P:endothelial cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900747">
        <property type="term" value="P:negative regulation of vascular endothelial growth factor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090263">
        <property type="term" value="P:positive regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010595">
        <property type="term" value="P:positive regulation of endothelial cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045765">
        <property type="term" value="P:regulation of angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050920">
        <property type="term" value="P:regulation of chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090210">
        <property type="term" value="P:regulation of establishment of blood-brain barrier"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002040">
        <property type="term" value="P:sprouting angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.220.50:FF:000012">
        <property type="entry name" value="Adhesion G protein-coupled receptor A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000496">
        <property type="entry name" value="Adhesion G protein-coupled receptor A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000287">
        <property type="entry name" value="adhesion G protein-coupled receptor A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.10">
        <property type="entry name" value="GPCR, family 2, extracellular hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051963">
        <property type="entry name" value="Adhesion_GPCR_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058808">
        <property type="entry name" value="GAIN_ADGRA2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036445">
        <property type="entry name" value="GPCR_2_extracell_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001879">
        <property type="entry name" value="GPCR_2_extracellular_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017983">
        <property type="entry name" value="GPCR_2_secretin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013151">
        <property type="entry name" value="Immunoglobulin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45930:SF1">
        <property type="entry name" value="ADHESION G PROTEIN-COUPLED RECEPTOR A2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 124-LIKE PROTEIN"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF26588">
        <property type="entry name" value="GAIN_ADGRA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
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    </dbReference>
    <dbReference type="Pfam" id="PF00047">
        <property type="entry name" value="ig"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
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    </dbReference>
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        <property type="match status" value="4"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00650">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G_PROTEIN_RECEP_F2_3"/>
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        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="9 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="13" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="941"/>
            <end position="962"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="974"/>
            <end position="994"/>
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    <feature type="transmembrane region" description="Helical" evidence="16">
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            <begin position="1000"/>
            <end position="1024"/>
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            <begin position="1056"/>
            <end position="1076"/>
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    <feature type="transmembrane region" description="Helical" evidence="16">
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            <begin position="1096"/>
            <end position="1119"/>
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    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1175"/>
            <end position="1196"/>
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    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1202"/>
            <end position="1223"/>
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        <location>
            <begin position="421"/>
            <end position="516"/>
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    <feature type="domain" description="G-protein coupled receptors family 2 profile 1" evidence="18">
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            <begin position="505"/>
            <end position="600"/>
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            <begin position="768"/>
            <end position="928"/>
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            <begin position="938"/>
            <end position="1229"/>
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            <begin position="183"/>
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            <begin position="1323"/>
            <end position="1347"/>
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        <location>
            <begin position="1405"/>
            <end position="1424"/>
        </location>
    </feature>
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    <sequence length="1467" mass="158792" checksum="6BD4AEF87F55EEA6" modified="2022-01-19" version="1">MVCMDHVSCVGAGLHLSSWTHGAASLSMDARGSVSISPWMPRVPSVSCTLDAQHSTSLSGCSALHLSMNAQHSISPWMLSTPSRSLDAQHSISPPGRALLQLCALVPAPCRLTEPFIPQPRAGTGAALPSRGPRSEPAGWWPGRGEEEEKEEVAATVGGGPGEAPGLAAERCKRGRRRRSRPGARGAEAPGAGAMRGAAAALLLAVATVLSEAAVRSCAVQSVGCKCAAERHKASGPAVPRRRVLCSGAALPEPPEPRLLPDGTATLLLSNNKITVLQNGSFFGLRALEKLDLKNNLISTVQPGAFLGLPELKRLDLSNNRIGCLSASVFQGLTNLLRLNMSGNIFSSLPPGVFDELPSLKVVDFATEYLTCDCNLRWVLPWARNLSAQISERTLCVYPRHLHTTPLRSAQESQLQCAGTPELHTHHLIPSLRQVVFQGDRLPFQCTATYLDNSTQIHWYHNQQRVQEDERAGVIVEESLIHDCTFITSELILSNIHVSANGEWECTVSTSQGNVSKKVEIVVLETSASYCPAERVTNNRGDFRWPRTLAGITAFQSCLQYPFASGPASGGPAAEKQASRRCDRAGRWEEGDYSHCLYTNDITRVLYTFVLMPINASNALTLAHQLRVYTAEAANFSDMVDVLYVAQMIEKFIGYVDQIKQLTDVIVEMASNIMLVDDHILWMSQKEEKACTSIIRSLEKIAAHTLSSNSQHMAVNSRNIAFEAYVVKPESYVGLSCVAFQRRDGGPAGRTALAEQAAEPQPDQQLQLRCTTGRPNISLSSFHIKNSIALASIQLPPSLFASPVPPTPLADCKLQLLVFRNGKLFCSTGNSSRLADDGKRRSVATPVIYAGTYGCSVGNLTEPVAVSLRHPGEGADPVAAYWNFEVLGGMGGWSAEGCQLAAREPNVTSLHCRHLSNVAVLMELSGFPSEARGPVEVLHPAMYTCTAVLLLCLFTTIITYIVHHGTIHITRKCWHMLLNLCFHMAMTSAVFAGGITLTGYLVVCQAVGIILHYSSLSTLLWMVVKARVLYKEATWKAPRQPDGDSAPPAPRPMLRFYLIAGGIPLIICGITAAVNIHNYHDNNPYCWLVWRPSLGAFYVPVAFILLVTWLYLLCAGLSLQCHTPHGKEAPELPGTPPRLGANGELLTDSGSISVTLHSGTHCPEVDGVYSLQAQLWALLAVHAMYVALWTFGAMAVSQRGDLNVVFSCLYGVTAVALGLFIFIHHCVRRRDVLGSWFSCCPSYRSALPMQPYSHPGTAAVEDGSQMFIGCDPEAARSATSSSSPSSTGSAAGRCKLTNLRAAQSQAEGPEHGDGRSAGPGRHTNNHRRNHKSRTKQHREGKHHRLKVLRGPSSEQSESGSVHNSHSESYHSSRNSPMNNCAAPRAVGPQDGEMAPSQSEGSDGFLEARRRSRDNVRQVEREAKRRSYPLNVGNHNGGLKGSKYDVNLTGADSAAGMRSGLWKSETTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TWL1</accession>
    <name>A0A8C2TWL1_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Spire type actin nucleation factor 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">SPIRE2</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the spire family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TWL1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005025733.1">
        <property type="protein sequence ID" value="ENSCJPP00005018497.1"/>
        <property type="gene ID" value="ENSCJPG00005015065.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000003058"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032154">
        <property type="term" value="C:cleavage furrow"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051639">
        <property type="term" value="P:actin filament network formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045010">
        <property type="term" value="P:actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036089">
        <property type="term" value="P:cleavage furrow formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051295">
        <property type="term" value="P:establishment of meiotic spindle localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070649">
        <property type="term" value="P:formin-nucleated actin cable assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040038">
        <property type="term" value="P:polar body extrusion after meiotic divisions"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000781">
        <property type="term" value="P:positive regulation of double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22068">
        <property type="entry name" value="WH2_DmSpire_r3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22079">
        <property type="entry name" value="WH2_Spire2_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22081">
        <property type="entry name" value="WH2_Spire2_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22065">
        <property type="entry name" value="WH2_Spire_1-2_r1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011019">
        <property type="entry name" value="KIND_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029901">
        <property type="entry name" value="Spire"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21345:SF5">
        <property type="entry name" value="PROTEIN SPIRE HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21345">
        <property type="entry name" value="SPIRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16474">
        <property type="entry name" value="KIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00750">
        <property type="entry name" value="KIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51377">
        <property type="entry name" value="KIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="KIND" evidence="15">
        <location>
            <begin position="12"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="123"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="407"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="451"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="407"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005018497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="702" mass="76998" checksum="AF67A8A094B504C2" modified="2022-01-19" version="1">MARAGGGGPRELSLEEVLKCYEQPLNEEQAWALCFQGCRAAAAAAAPSAAPLRTADIRLRGDGSVALPPPPPELPLLLTPAAEAQMVQSLGFAIYRALDWGLDENEERELSPQLEQLIDLMTNSDSEDSGCGTADEGYGGQEEEEESGEGPLRAVRTFGQAMRCCAARLADPNEAQAHYQAVCRALFAETVELKAFLAKIRDAKEMLQKLKEDEEAEERPAAELGSLRNTDWARLWVQLMRELRHGVKLKKVQEKQFNPLPTEYQLTPFEMLMQDIRARNYKLRKVMVDGDIPPRVKKDAHELILEFIRSRPPLKQASERRLRPLPQKQRTLHEEILEEIKQERKLRPVETSYRGQKGYSSLPCIPHACSSHLTSSSCIDLSMPEASTVPARPRPRILLKAPTLAEMEEMSISEEEDSPSTESVSGLPMKRDRSFSEQDLAQFQSELAGGHAAPKVLESLDPEPRPRSGSVPASYHPVPYGSTPRAALGAVEEKPEDGSSTAPSSSKHLWLEFSHPVESLALTVEEMINVRRVLVKAEMEKFLQSKELYNSLKKGKVGTGTGGAELPLYHLHLTLTLPVPTGLLLLPRQIPPLLLACSLPLLQAVSTVPCHAVLCCAALCCTPWCQSWWEGALVVALLTCFSPCSQVCLLLLQPEGKGPALLTVTNPSPSPCLTSWAVLIPHGPGVKGTPPGAAPDAHHPDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TWQ1</accession>
    <name>A0A8C2TWQ1_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein phosphatase, Mg2+/Mn2+ dependent 1H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">PPM1H</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TWQ1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005026337.1">
        <property type="protein sequence ID" value="ENSCJPP00005018984.1"/>
        <property type="gene ID" value="ENSCJPG00005015435.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160095"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004741">
        <property type="term" value="F:[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF287">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="74"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005018984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="491" mass="54083" checksum="CB4BE4DDE8B648FF" modified="2022-01-19" version="1">MLTRVKSAVANFMGGIMAGSAGAEHGGGADLPLRFPYGRPEFLGLSPDEVECSADHIARPILILSKETRRLPWTTGYAEVINAGKSTHNEDQASCEVLFVKKKTGGANSTPNKNSKRRSSLPNGEGLQLKDSSDGDGINLYYWSLFDGHAGSGAAVVASKLLQHHILEQLQEIVDILRNTAVLPPTCLGEEPDNTSSNSRTLTRAASLRGGVGAPGSPSTPPTRFFTEKKIPHECLVIGAIESAFKEMDLQIERERTVYNISGGCTALVVVYLLGKLYVANAGDSSSITRRFWFLAYMQPHLLGNEFTHLEFPRRVQRKEVGKRMLYRDFNMTGWAYKTIEEDDLKFPLIYGEGKKARVMATIGVTRGLGDHDLKVFSSNIHIKPFLSSSPEVRVYDLLQYEHGPDDVLILATDGLWDVLLNEEVAEAVTNFLPNCDPDDPHRYTLAAQDLVMRARGVLKDRGWRISNDRLGSGDDISVYVIPLIHGNKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TWW6</accession>
    <name>A0A8C2TWW6_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ring finger protein 224</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">RNF224</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TWW6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005027063.1">
        <property type="protein sequence ID" value="ENSCJPP00005019553.1"/>
        <property type="gene ID" value="ENSCJPG00005015840.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00510000050587"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16565">
        <property type="entry name" value="RING-HC_RNF224"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053122">
        <property type="entry name" value="RING_finger_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47454">
        <property type="entry name" value="RING FINGER PROTEIN 224"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47454:SF1">
        <property type="entry name" value="RING FINGER PROTEIN 224"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="33"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005019553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="223" mass="24326" checksum="BD50A9C2C88CEBBF" modified="2022-01-19" version="1">MSQAGGSPCAEDRGPSAEAHTRTLSRGSQKLECIICYSSYDPCVRLPRRLYCGHTFCQTCLKRLDTVANEQRWIPCPQCRQNTPTPRGGVTMLDLDLATFLLVKADKEHPRAATRSLQDVATKGLCKEPPVTQQPLGLCQDTVPRLPPEKSCQPCLPQLLGWGKEEVVLAMGAGTILQVGFLPSLLMHTLQALIPNLDSVSWVLESPWPLDAPTCRSLGHGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TYU7</accession>
    <name>A0A8C2TYU7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TYU7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005026907.1">
        <property type="protein sequence ID" value="ENSCJPP00005019431.1"/>
        <property type="gene ID" value="ENSCJPG00005015739.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153527"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001817">
        <property type="term" value="P:regulation of cytokine production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903037">
        <property type="term" value="P:regulation of leukocyte cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050863">
        <property type="term" value="P:regulation of T cell activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050852">
        <property type="term" value="P:T cell receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000142">
        <property type="entry name" value="V-set domain-containing T-cell activation inhibitor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050504">
        <property type="entry name" value="IgSF_BTN/MOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24100:SF149">
        <property type="entry name" value="BG-LIKE ANTIGEN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24100">
        <property type="entry name" value="BUTYROPHILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="22"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005019431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="151" mass="16617" checksum="5AC50CA811B8FE31" modified="2022-01-19" version="1">KADLAALHPTSPFHHLTISLCPSHCTAQLTVVAPNPHVTAIVGQDVVLRCHLSPCKDAWSSDIRWIQHGSAELLHHYQNGEDLEQMEEYKGRIELLRDGLSDGNLDLRITAVTSADSGTYSCVVQDGDHFAEGVMNLEVSGQWLGCLWMES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TYV2</accession>
    <name>A0A8C2TYV2_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat domain 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ANKRD10</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015706915.1">
        <property type="nucleotide sequence ID" value="XM_015851429.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TYV2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005027237.1">
        <property type="protein sequence ID" value="ENSCJPP00005019701.1"/>
        <property type="gene ID" value="ENSCJPG00005015939.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107307940"/>
    <dbReference type="CTD" id="55608"/>
    <dbReference type="GeneTree" id="ENSGT00940000156564"/>
    <dbReference type="OrthoDB" id="5402602at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050776">
        <property type="entry name" value="Ank_Repeat/CDKN_Inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201:SF12">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="54"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="88"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="121"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="305"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005019701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="414" mass="44352" checksum="51A3204F57FFEFC9" modified="2022-01-19" version="1">MSLGAGPEAGFSSEELLTLRFPLHRACRDGDLPALCALLQSAPRSDLAAEDSFYGWTPIHWAAHFGKLECLMQLVRAGASVNASTTRFAQTPAHVAAFGGHPQCLNWLIQVGANINKQDYVGETPIHKAARSGSVDSISALVAHGAQIDLRNASGLTAADLAHTQGFQECAQFLLNLQNCHLNRYYSNGTLNGGHQNPGPNPFSGGTSRKRSFEDVESAGVKKARTEAYSFDGLIPMMNGGVEDDADNMHVDREFAVVSDMNSSSSILNALTNGCAINGHLDFAAAQQLSGMDTRQEECLTLTPNGIIPGVTSPGRHRVHTSNGTEEPEKAMNNPTDMCGSLHLNGSPSSCVSNRPSWVEDPGDTLHYGHYHGFGDTAESIPELSSVVEHSNSVKVEQRYDSTVLGTMYLYHGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TZ51</accession>
    <name>A0A8C2TZ51_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Potassium calcium-activated channel subfamily M regulatory beta subunit 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">KCNMB4</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015711475.1">
        <property type="nucleotide sequence ID" value="XM_015855989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TZ51"/>
    <dbReference type="Ensembl" id="ENSCJPT00005027418.1">
        <property type="protein sequence ID" value="ENSCJPP00005019833.1"/>
        <property type="gene ID" value="ENSCJPG00005016047.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107310398"/>
    <dbReference type="KEGG" id="cjo:107310398"/>
    <dbReference type="CTD" id="27345"/>
    <dbReference type="GeneTree" id="ENSGT00950000183039"/>
    <dbReference type="OrthoDB" id="9932001at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015269">
        <property type="term" value="F:calcium-activated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015459">
        <property type="term" value="F:potassium channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005513">
        <property type="term" value="P:detection of calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019228">
        <property type="term" value="P:neuronal action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003930">
        <property type="entry name" value="K_chnl_Ca-activ_BK_bsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10258">
        <property type="entry name" value="CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10258:SF3">
        <property type="entry name" value="CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT BETA-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03185">
        <property type="entry name" value="CaKB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005019833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="211" mass="23497" checksum="6356708BF74AB6DB" modified="2022-01-19" version="1">MARGRAAYEYTEAEDKSMRLGFLLIAAGLLSLLGLGCCWLRPALQERGGGGAANCTVLAVRQLGERFACTFSCGAACRGTARYPCLQVLVRTSRSAAPALLHEDERQLRTNPKCSYIPPCARDDQENSENVTYKQKYWKEKVGSQPFTCYFNQHLRPDDVMLKRTHDETVLLHCFLWPLVTFLVGVLIVALTACARSLAARAEAIQRKKHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U020</accession>
    <name>A0A8C2U020_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tryptophan 5-hydroxylase 2</fullName>
            <ecNumber evidence="4">1.14.16.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Tryptophan 5-monooxygenase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">TPH2</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin</text>
            <dbReference type="Rhea" id="RHEA:16709"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15642"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58266"/>
            <dbReference type="ChEBI" id="CHEBI:59560"/>
            <dbReference type="EC" id="1.14.16.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Aromatic compound metabolism; serotonin biosynthesis; serotonin from L-tryptophan: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Interacts with DNAJC12.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.16.4" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2U020"/>
    <dbReference type="Ensembl" id="ENSCJPT00005027515.1">
        <property type="protein sequence ID" value="ENSCJPP00005019911.1"/>
        <property type="gene ID" value="ENSCJPG00005016097.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182885"/>
    <dbReference type="UniPathway" id="UPA00846">
        <property type="reaction ID" value="UER00799"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004510">
        <property type="term" value="F:tryptophan 5-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009072">
        <property type="term" value="P:aromatic amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042427">
        <property type="term" value="P:serotonin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04929">
        <property type="entry name" value="ACT_TPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03346">
        <property type="entry name" value="eu_TrpOH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.800.10:FF:000001">
        <property type="entry name" value="tryptophan 5-hydroxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.800.10">
        <property type="entry name" value="Aromatic amino acid hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001273">
        <property type="entry name" value="ArAA_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018301">
        <property type="entry name" value="ArAA_hydroxylase_Fe/CU_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036951">
        <property type="entry name" value="ArAA_hydroxylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036329">
        <property type="entry name" value="Aro-AA_hydroxylase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019774">
        <property type="entry name" value="Aromatic-AA_hydroxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005963">
        <property type="entry name" value="Trp_5_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041904">
        <property type="entry name" value="TrpOH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019773">
        <property type="entry name" value="Tyrosine_3-monooxygenase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01270">
        <property type="entry name" value="Trp_5_monoox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11473">
        <property type="entry name" value="AROMATIC AMINO ACID HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11473:SF16">
        <property type="entry name" value="TRYPTOPHAN 5-HYDROXYLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00351">
        <property type="entry name" value="Biopterin_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000336">
        <property type="entry name" value="TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00372">
        <property type="entry name" value="FYWHYDRXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56534">
        <property type="entry name" value="Aromatic aminoacid monoxygenases, catalytic and oligomerization domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00367">
        <property type="entry name" value="BH4_AAA_HYDROXYL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51410">
        <property type="entry name" value="BH4_AAA_HYDROXYL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0408">Iron</keyword>
    <keyword evidence="6 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0724">Serotonin biosynthesis</keyword>
    <feature type="domain" description="ACT" evidence="20">
        <location>
            <begin position="64"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Biopterin-dependent aromatic amino acid hydroxylase family profile" evidence="19">
        <location>
            <begin position="138"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="24"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>L-tryptophan</name>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>L-tryptophan</name>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>L-tryptophan</name>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="362"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="381"/>
        </location>
        <ligand>
            <name>L-tryptophan</name>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>L-tryptophan</name>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00062416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000336-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR601273-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR601273-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005019911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="487" mass="55757" checksum="159EAFFC2BAA8112" modified="2022-01-19" version="1">MQPAMMMFSSKYWARRGFSLDSALPEERPGGLTINRSNSGKNEEKKGNKGNGKGESVSEGGKTAVVFSLKNEVGGLVKALRLFQEKHVSMVHIESRKSKRRNSEVEIFVDCDCSKKEFNELIQLLKFQTNIVSLNPPENIWTDEEDLDCVPWFPRKISELDKCSQRVLMYGSELDADHPGFKDNVYRQRRKYFVDVAMSYKYGQPIPRVEYTAEEIKTWGVVFRELSKLYPTHACREYLKNFPLLTKYCGYREDNVPQLEDVSVFLKERSGFTVRPVAGYLSPRDFLAGLAYRVFHCTQYVRHGSDPLYTPEPDTCHELLGHVPLLADPKFAQFSQEIGLASLGASDEDVQKLATCYFFTIEFGLCKQEGQLRAYGAGLLSSIGELKHALSDKAKVKTFDPKTTCLQECLITTFQEAYFVSESFEEAKEKMRDFAKSINRPFSVYFNPYTQSIEILKDTRSIENVVQDLRSDLNTGLPFVFWRTTNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U080</accession>
    <name>A0A8C2U080_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Calcium binding protein 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">CABP7</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="13">Interacts with PI4KB. This binding competes with FREQ/NCS1 binding in a calcium-dependent manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Golgi apparatus</location>
            <location evidence="12">trans-Golgi network membrane</location>
            <topology evidence="12">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2U080"/>
    <dbReference type="Ensembl" id="ENSCJPT00005026692.1">
        <property type="protein sequence ID" value="ENSCJPP00005019237.1"/>
        <property type="gene ID" value="ENSCJPG00005015638.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159368"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032588">
        <property type="term" value="C:trans-Golgi network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000115">
        <property type="entry name" value="Calcium-binding protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051111">
        <property type="entry name" value="Ca-binding_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001751">
        <property type="entry name" value="S100/CaBP7/8-like_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46311:SF1">
        <property type="entry name" value="CALCIUM-BINDING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46311">
        <property type="entry name" value="CALCIUM-BINDING PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00303">
        <property type="entry name" value="S100_CABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="15">
        <location>
            <begin position="87"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="15">
        <location>
            <begin position="123"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005019237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="267" mass="29406" checksum="95E20B29260395EE" modified="2022-01-19" version="1">MCYPQHHPYTTISPSPSAAPEVGSPTVALIEAFGFGVNLISALGQEPTDLRTPPRSALYLGTLWAPSPLCLSLPITVGSGLAGLSPIPPTEIREAFKVFDRDGNGFISKQELGTAMRSLGYMPNEVELEVIIQRLDMDGDGQVDFEEFVTLLGPKLSTSGIPEKFHGTDFDTVFWKCDMQKLTVDELKRLLYDTFCEHLSMKDIENIIMTEEESHMGTAEECPVEVESDQQIRQTCVRKSLICAFAIAFIISVMLIAANQVLRSGMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U1T9</accession>
    <name>A0A8C2U1T9_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Sorbin and SH3 domain containing 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">SORBS1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Focal adhesion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2U1T9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005029537.1">
        <property type="protein sequence ID" value="ENSCJPP00005021511.1"/>
        <property type="gene ID" value="ENSCJPG00005016587.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00900000142007"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031589">
        <property type="term" value="P:cell-substrate adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11919">
        <property type="entry name" value="SH3_Sorbs1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11922">
        <property type="entry name" value="SH3_Sorbs1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000001">
        <property type="entry name" value="Sorbin and SH3 domain-containing protein 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000003">
        <property type="entry name" value="Sorbin and SH3 domain-containing protein 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000004">
        <property type="entry name" value="Sorbin and SH3 domain-containing protein 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050384">
        <property type="entry name" value="Endophilin_SH3RF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003127">
        <property type="entry name" value="SoHo_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035610">
        <property type="entry name" value="SORBS1_SH3_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035611">
        <property type="entry name" value="SORBS1_SH3_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167:SF64">
        <property type="entry name" value="SORBIN AND SH3 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02208">
        <property type="entry name" value="Sorb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00459">
        <property type="entry name" value="Sorb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50831">
        <property type="entry name" value="SOHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0965">Cell junction</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034901412" evidence="13">
        <location>
            <begin position="21"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="domain" description="SoHo" evidence="15">
        <location>
            <begin position="144"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="14">
        <location>
            <begin position="1005"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="14">
        <location>
            <begin position="1079"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="14">
        <location>
            <begin position="1167"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="87"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="191"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="403"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="723"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="758"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="802"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="874"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="87"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="126"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="216"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="247"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="723"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="839"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="874"/>
            <end position="886"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005021511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1228" mass="137946" checksum="6D26CA1C2D8A1CD1" modified="2022-01-19" version="1">MLKLLHRALMVPNSFVSSLSLCLFCACTFPLETDPTKICSGKGAVTLWASSASEENQKIFSPYPPQDAEKPESNFFLSFLDDWRSSPNTDANGDAQPSSLAAKGYRSVRPNLSSDSKPQVTPVLNEVTQPSSGTDYPTSFTSINKSSSAYPSTTIVNPTIVLLQHNRGKETSRSKDWYKTMFKQIHKLNRDEDSDSYSPRYSYCEDTRSQPSVPRSKSEMDHIDSEKVFKRSATLPLPNRTSSLKSSPERTDWEPPDKKVDTRKYRAEPRSIYDYQPGKSSVLNSEKMTRDISPEEIDLKNEPWYKFFSELEFGKPSDLEKDLYLYQTELEADLEKMEKLYKAPHKKPQKVFPILFISTYSPNYHSAKRDSEPALGDFAGLENERQIYKSVLEGGDIPFQGLSGLKRPSSSASTKVDRKGGNAHMTAPSSVNSRTFNASHTGMLGQACKHKKPLSAAKACITEILPSKFKPKLAAPAALEQDKKGILLSHEKAQSCENLRSSIALFDNKKSFMVDVGESIENMLMKSKQEYAIKSGSTMSLQEYGTNSRKGYLFPASRKSGMEFTMLYKDMHQINRSRIQLGTVSSCSVRDIASQFENEAKDRMEHSLSREDSEQIPKDTVSSRISAFEQLIQRSRSMPALDFTTGQSKFTTSLQSKACLGSAYSAEILLDLPKINQEGKDAASLADKSSRSCSNVEDTASDVSDAIPMDTLSGCTDEIDLLSNASNDSGGSSSNINGPQKHKINRCKGTCPASYTRFTTIRRHEQQQSSRSTDSKGIYGDKHTLPRNVYLMSPLPFRVKKPFQHKSSRTPPPDCPGALAVPSPENPDDPIQLQGSVGDKSHHSQHELCSRSRPLAPRRLSSFDILERLSYFPSMGSSRDSSMGRSDTPDSLHNGNPVPYALYHSLDTNNNPQSELGTYLGDSESPRHFAPVDYMETPEEIIRRRYDDKEKLLEDQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDLLNVDDTAKRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRSYIELLPPAEKAQPKKPLPLQVLEYGDAIAKFNFNGDTQVEMSFRKGERITLIRRVDENWYEGRISGTSRQGIFPVTYVEVLKRPVVKNAIDYPDPPVSLSPNRSVTASPQVFGLDATLYSYTPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTRQFGTFPGNYVKLLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U207</accession>
    <name>A0A8C2U207_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Nucleoside diphosphate kinase</fullName>
            <ecNumber evidence="16">2.7.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">NME4</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:18113"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Mitochondrion intermembrane space</location>
            <topology evidence="13">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 14 15">Belongs to the NDK family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="16"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2U207"/>
    <dbReference type="Ensembl" id="ENSCJPT00005029051.1">
        <property type="protein sequence ID" value="ENSCJPP00005021119.1"/>
        <property type="gene ID" value="ENSCJPG00005016910.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160286"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901612">
        <property type="term" value="F:cardiolipin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160204">
        <property type="term" value="F:mitochondrion-mitochondrion outer membrane tether activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140339">
        <property type="term" value="F:phosphatidylglycerol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120010">
        <property type="term" value="P:intermembrane phospholipid transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034214">
        <property type="term" value="P:protein hexamerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04413">
        <property type="entry name" value="NDPk_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.141:FF:000017">
        <property type="entry name" value="Nucleoside diphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00451">
        <property type="entry name" value="NDP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023005">
        <property type="entry name" value="Nucleoside_diP_kinase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001908">
        <property type="entry name" value="PRK00668.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11349">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00469">
        <property type="entry name" value="NDPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51374">
        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="8 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside diphosphate kinase-like" evidence="18">
        <location>
            <begin position="47"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="13"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="14">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00060410"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005021119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="196" mass="21657" checksum="AE503255FC9A11B8" modified="2022-01-19" version="1">MFPWPGLPAAAAALRGGPSRSRRALKASPRGGRAPLRTSRPAPPELREQTLVLVKPDAVQRRLVGDVIGRFERRGFKLVAMKLLQADRGLLDQHYQHLQQKPFYPALLAYMTSGPLVAMVWEGYNVVRSTRAMVGDTDSAKAAAGTIRGDLSMHVSRNVVHASDSVETALKEIGFWFQRDELVAWECGDSQYTYGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U2C5</accession>
    <name>A0A8C2U2C5_COTJA</name>
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        <recommendedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
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        <lineage>
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                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U2C5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005029220.1">
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        <property type="gene ID" value="ENSCJPG00005017017.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234920"/>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="entry name" value="IgC1_TCR_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Immunoglobulin kappa constant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003597">
        <property type="entry name" value="Ig_C1-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050160">
        <property type="entry name" value="MHC/Immunoglobulin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19944:SF98">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19944">
        <property type="entry name" value="MHC CLASS II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07654">
        <property type="entry name" value="C1-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00407">
        <property type="entry name" value="IGc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="10"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005021263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="115" mass="12814" checksum="EB071CDB6BB6D375" modified="2022-01-19" version="1">GQPNDEIIPPAVAIFSPSKQEIQQKNKATLVCLASGFYPDNLNLVWKVNGVKRTEGVGTDETSTSNGSTYALTSRLRISAQEWFNPLNRFECIANFFKNKTLESIHKFIYGDTGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U2K0</accession>
    <name>A0A8C2U2K0_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Klotho beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">KLB</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the glycosyl hydrolase 1 family. Klotho subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2U2K0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005030672.1">
        <property type="protein sequence ID" value="ENSCJPP00005022384.1"/>
        <property type="gene ID" value="ENSCJPG00005017841.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157489"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017134">
        <property type="term" value="F:fibroblast growth factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005104">
        <property type="term" value="F:fibroblast growth factor receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090080">
        <property type="term" value="P:positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000042">
        <property type="entry name" value="Klotho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000062">
        <property type="entry name" value="Klotho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="GH_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353:SF68">
        <property type="entry name" value="BETA-KLOTHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="985"/>
            <end position="1005"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005022384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1033" mass="119388" checksum="283DAE2AC73B3754" modified="2022-01-19" version="1">VKTACTTGTPGNEWISFGTGEGNQTFNLKRFVAFWTLVFVRIAAGLAGEGRSVWKKDPNSSPVSETQMFLYDTFPTEFLWGVGTGAFQVEGSWRKDKRGPSVWDRFIHTELRDTERANVSSDSYTLLDKDLSALGFLGVTFYQFSISWSRLFPTGVVAAPNEKGLQYYNTLIDSLLYRNIDPVVTLYHWDLPLALQEQYGGWKNESVIDIFNDYATFCFQTFGDRVKYWITIHNPYLVAWHGYGTGIHAPGEKGKITTVYAVGHNLIKAHAKVWHNYKKHFHPYQKGLMSIVLGSHWIEPNRSEDTLDISKCQQSVERVLGWFAKPIHGDGDYPEELKNESFLPRFTEDEKKYIKGTADFFAFSFGPDNFKPPNTLPKLGQNLSLNLREVLNWIKLEYDSPRIFIAENGWFTDSHVKTDDTTAIYMMKNFINKVLQAIKYDNIDVFGYTAWSLLDGFEWQHAYKIRRGLFYVDFRSEQKERIPKSSALYYKQIIQENGFFPRESTPSVQAQFSCDFSWGITESVLKAESVASSPQFCDPNLYLWNITGDGLLHKVEGVKLKTRPAQCTDFVSIKKQLDLLEKMKVTHYRFALDWSLILPNGDLSVVNRQVLRYYRCVISEVLKLNIQAMVTLYYPTHAYLGLPGPLLQTGGWLNQSTAFAFQDYAALCFQELGDLVKLWITINEPNRLSDVYNRSSSDTYRAAHNLLIAHAMAWRTYDVQYRPFQYGKVSLTLHSDWAEPANPYFESHAKAANRFLQFEIGWFADPIFKTGDYPATMREYIHFKNKKGLSHSSLPSFTSEERKLIKGAADFYALNHFTTRFVIHEPQNGSQYEFDRDIQFLQDITCLSSPSRLAVVPWGVRKVLKWIKRTYGDIDIYITANGIDDQSLDNDELRTYYLEKYVQEVLKAYYIDKVKIRGYYAFKLTEEKSKPRFGFFTSDSKGKPSIRFYNNLISNNGFPADYSVCDLSNEKQCSFCLFVSQKKPLIFFACCLFSTLILLLTIIVFHKRKRRKRFKPKRIQRICVKKRGKPAYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U2W2</accession>
    <name>A0A8C2U2W2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Threonylcarbamoyl-AMP synthase</fullName>
            <ecNumber evidence="5">2.7.7.87</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC107312864</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonine + hydrogencarbonate + ATP = L-threonylcarbamoyladenylate + diphosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:36407"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="EC" id="2.7.7.87"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SUA5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.87" evidence="5"/>
    <dbReference type="RefSeq" id="XP_015716159.1">
        <property type="nucleotide sequence ID" value="XM_015860673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U2W2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005029057.1">
        <property type="protein sequence ID" value="ENSCJPP00005021125.1"/>
        <property type="gene ID" value="ENSCJPG00005016919.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107312864"/>
    <dbReference type="KEGG" id="cjo:107312864"/>
    <dbReference type="GeneTree" id="ENSGT00390000015364"/>
    <dbReference type="OrthoDB" id="3648309at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061710">
        <property type="term" value="F:L-threonylcarbamoyladenylate synthase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.870.10:FF:000010">
        <property type="entry name" value="Si:ch211-153b23.4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.10">
        <property type="entry name" value="DHBP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="Sua5-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050156">
        <property type="entry name" value="TC-AMP_synthase_SUA5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17490">
        <property type="entry name" value="SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17490:SF14">
        <property type="entry name" value="THREONYLCARBAMOYL-AMP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="YrdC/RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="21"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="364"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="539"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="571"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="596"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="622"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="domain" description="YrdC-like" evidence="14">
        <location>
            <begin position="683"/>
            <end position="878"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005021125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="895" mass="96715" checksum="D67A056C53CF1881" modified="2022-01-19" version="1">MWRDGEIVGMTTDTLVLSERAMVSTVGFAAVFYSEPAVLGLLANVVSAFLLCLQNFATVHTGLRPQGAEDVLTGVHLILIGGFVQLLAGFLAFRKYDHLGGAAFLTFSALWSSYGATRIISAAYPPLQNITLSSGNTSQLLSTTMTHLSTSQSAVAGLVAYISISFILSFCSATVNYIMPFIFGAIALALVFEAVALFGQWALIVSGVIELVIVLCGLYGAMALLLKGITQRYILPGFGHPLFNVLLLGSAQKSSSKAIGEEKKKNTKYAEPMALGNICDTVSPFIFAFYFFGYMKTFCVGAAWISIISSCQLLSSFYSYLRGDVYYTTKFGAHSLFWLVMSWEEFVLTTFLEPGKAQESRLGMFGGWFFLVVACMLFLISTHKDTLEMLQNASFIILTSAFIHQIPVSGAYPFLGAACSLCTALSMYATFASLINSIGEKALIPVGKQALSSSALQTTLMAAKMCFTRSKNLPSGTKAEVPDALFYICNGLAAVSAIQGTLSDPSRQQLSIPSVLIPGAIVQLYVCRIQVQGGRRFGCVLPFCYSAFWGAWTWLRFAGHLLNIGAGNSEGFTAGAIAFLVINAFLMILASSFNVVLLFMTLAVELLTICFLLFTLENLPLPFEIVMLCIFSIICFYGATASLANSMFGKDLMMMGPSLFTAQSSKKNTEDSPPCICPKSHCTSGLRTIADLLNTGAVCGVPTDTVYALAASCRHPQAIEKVYRIKDRPQEKPICIFISNLDQLRAAAPPISPLLWEFMENVYPGGVGCIIKKGEWLKKLGVGEGYSRVGTQDSIMIRVPDLTVLVHLIDMTGPLAITSANPSGEVDSTHHDMVISRLGHKLEGVLCDGESDEVVASTVVNCTRIDESGITILREGCIPAGKVMQIFERIKNRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U3Q8</accession>
    <name>A0A8C2U3Q8_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transmembrane protein 35B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">TMEM35B</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DoxX family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2U3Q8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005029359.1">
        <property type="protein sequence ID" value="ENSCJPP00005021380.1"/>
        <property type="gene ID" value="ENSCJPG00005017100.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154325"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040399">
        <property type="entry name" value="TMEM35A/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13163">
        <property type="entry name" value="SPINAL CORD EXPRESSION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13163:SF2">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 35B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034295451" evidence="7">
        <location>
            <begin position="19"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005021380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="141" mass="14831" checksum="6391D8F94573EA27" modified="2022-01-19" version="1">RIGLLPLLSLLGVPGGSAPHGAPAGRRYRSRAPLCALQQEQFVRFAEVFPLKDFGFAPSPGSYLAAVGAVEALAGLLLAFGPQLLQEISNFVLSVVMIGAIYTLLVLREPLAMCAPATLSLGLLLLLNVRGHAAPTKTKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U537</accession>
    <name>A0A8C2U537_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Glutamine synthetase</fullName>
            <ecNumber evidence="3 11">6.3.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC107321620</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-glutamate + NH4(+) + ATP = L-glutamine + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16169"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="3 11"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2U537"/>
    <dbReference type="Ensembl" id="ENSCJPT00005030749.1">
        <property type="protein sequence ID" value="ENSCJPP00005022439.1"/>
        <property type="gene ID" value="ENSCJPG00005017874.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000164772"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamine synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.70:FF:000004">
        <property type="entry name" value="Glutamine synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.10:FF:000011">
        <property type="entry name" value="Glutamine synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027302">
        <property type="entry name" value="Gln_synth_N_conserv_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050292">
        <property type="entry name" value="Glutamine_Synthetase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20852">
        <property type="entry name" value="GLUTAMINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20852:SF43">
        <property type="entry name" value="GLUTAMINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00180">
        <property type="entry name" value="GLNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51986">
        <property type="entry name" value="GS_BETA_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51987">
        <property type="entry name" value="GS_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GS beta-grasp" evidence="12">
        <location>
            <begin position="26"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="GS catalytic" evidence="13">
        <location>
            <begin position="113"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005022439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="374" mass="42079" checksum="0D7C0615C99D49F8" modified="2022-01-19" version="1">MSVSHSSRLNKLVREQYMRLPQGGLVQVTYVWIDGSGEGVRCKSRTLDKEPKSIEDVPEWNFDGSSTAQAEGSNSDMFLVPVCMFRDPFCLDPNKLVLCEVLKYNRKPAETNLRHTCKKVMDLVKDSHPWFGMEQEYTLLGVNGHPYGWPDNGFPGPQGPYYCGVGADKVYGRDIVESHYKACLYAGVKICGTNAEVMPSQWEFQVGPCEGIEMGDHLWMARFILHRVCEDFGVVATLDPKPMTGNWNGAGCHTNYSTEEMRKEGGLKHIEAAIEKLSKRHDYHICVYDPRGGRDNSRRLTGHHETSNIFEFSAGVANRGASIRIPRQVGQDGFGYFEDRRPAANCDPYAVTEAIMRTTVLNETGVETKEYNWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U5B9</accession>
    <name>A0A8C2U5B9_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Karyopherin subunit alpha 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">KPNA4</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the importin alpha family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2U5B9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005031173.1">
        <property type="protein sequence ID" value="ENSCJPP00005022730.1"/>
        <property type="gene ID" value="ENSCJPG00005018078.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01050000244891"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001673">
        <property type="term" value="C:male germ cell nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042564">
        <property type="term" value="C:NLS-dependent protein nuclear import complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014046">
        <property type="term" value="P:dopamine secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006607">
        <property type="term" value="P:NLS-bearing protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035332">
        <property type="term" value="P:positive regulation of hippo signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042542">
        <property type="term" value="P:response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="Importin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000009">
        <property type="entry name" value="Importin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.690">
        <property type="entry name" value="Importin-alpha, importin-beta-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032413">
        <property type="entry name" value="Arm_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002652">
        <property type="entry name" value="Importin-a_IBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036975">
        <property type="entry name" value="Importin-a_IBB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23316">
        <property type="entry name" value="IMPORTIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16186">
        <property type="entry name" value="Arm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01749">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="IBB" evidence="14">
        <location>
            <begin position="143"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="11">
        <location>
            <begin position="262"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="11">
        <location>
            <begin position="305"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="11">
        <location>
            <begin position="432"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="69"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="71"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="124"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005022730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="669" mass="72343" checksum="3954CD800AB0B97C" modified="2022-01-19" version="1">MAAPKLLEGLRPLPPLPVTSHVTAPLSSRPLPPRSHWPPAAGCSSNGRAVPCGPERGCVSPLPPLCPSPAPARSAPGSGSAARSPHSAHSPHGPGSAHGPHGSYGPFGRCRERPAVGRSYRATGPGGEKGGGGGGGGAAALPPTFPPAMADNEKLDNQRLKNFKNKGRDLETMRRQRNEVVVELRKNKRDEHLLKRRNVPHEDICEDSDIDGDFRVQNTSLEAIVQNASSDNQGIQLSAVQAARKLLSSDRNPPIDDLIKSGILPILVHCLERDDNPSLQFEAAWALTNIASGTSEQTQAVVQSNAVPLFLRLLHSPHQNVCEQAVWALGNIIGDGPQCRDYVISLGVVKPLLSFISPSIPITFLRNVTWVMVNLCRHKDPPPPMETIQEILPALCVLIHHTDVNILVDTVWALSYLTDAGNEQIQMVIDSGIVPHLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCEALSHFPALLTHPKEKINKEAVWFLSNITAGNQQQVQAVIDANLVPMIIHLLDKGDFGTQKEAAWAISNLTISGRKDQVAYLIQQNVIPPFCNLLTVKDAQVVQVVLDGLSNILKMAEDEAETIANLIEECGGLEKIEQLQNHENEDIYKLAYEIIDQFFSSDDIDEDPSLVPEAIQGGTFGFNSSANVPAEGFQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U5F9</accession>
    <name>A0A8C2U5F9_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NFKB activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">NKAP</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NKAP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2U5F9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005032529.1">
        <property type="protein sequence ID" value="ENSCJPP00005023795.1"/>
        <property type="gene ID" value="ENSCJPG00005018808.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160787"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030851">
        <property type="term" value="P:granulocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071425">
        <property type="term" value="P:hematopoietic stem cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046638">
        <property type="term" value="P:positive regulation of alpha-beta T cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035019">
        <property type="term" value="P:somatic stem cell population maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033077">
        <property type="term" value="P:T cell differentiation in thymus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040466">
        <property type="entry name" value="NKAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009269">
        <property type="entry name" value="NKAP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13087">
        <property type="entry name" value="NF-KAPPA B ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13087:SF0">
        <property type="entry name" value="NFKB ACTIVATING PROTEIN LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06047">
        <property type="entry name" value="Nkap_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NF-kappa-B-activating protein C-terminal" evidence="3">
        <location>
            <begin position="323"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="76"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="268"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="114"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="148"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="189"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005023795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="430" mass="48860" checksum="8B3854A524DB1E25" modified="2022-01-19" version="1">MCRPAPGIGHRGSRPGERSPSLGAHPAPHRRPPAAPGCRPLPVRRPPAPPYLAAAVPAPPWCRAVTKERPRRRVAVFPHGRWGTAPRGRGCPASAPRPVAAASRPRPSSAARPGGRRKCRQAARKCRRAIMAPVSRSRSPAAASPERRGRRSRSRSRSRSRNGSRRGCHRRSRSWSRSRERSPGGTRASAHHGHHHGKAWPEYYEKEKEEILRQRRLNERERIGELGAPEVWGLSPKALLLWDAPDVYTELSLHLFLMLSFINIPEEKRKKKKKRKKRKRKASKRKHRKHSEDSDSESESDQSSSGKGEQMMSKLCIEMFWWSYGHALLPGEGAAMAEYVKAGKRIPRRGEIGLTSEEIASFESSGYVMSGSRHRRMEAVRLRKENQIYSADEKRALASFNQEERRKRENKILASFREMVYRKTKGKEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U5U4</accession>
    <name>A0A8C2U5U4_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA N(3)-cytidine methyltransferase</fullName>
            <ecNumber evidence="6">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">METTL8</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">S-adenosyl-L-methionine-dependent methyltransferase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the methyltransferase superfamily. METL family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2U5U4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005030649.1">
        <property type="protein sequence ID" value="ENSCJPP00005022361.1"/>
        <property type="gene ID" value="ENSCJPG00005017829.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159683"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008174">
        <property type="term" value="F:mRNA methyltransferase activity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="F:tRNA (cytidine-3-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045444">
        <property type="term" value="P:fat cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:skeletal muscle tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000151">
        <property type="entry name" value="Methyltransferase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026113">
        <property type="entry name" value="METTL2/6/8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809:SF3">
        <property type="entry name" value="TRNA N(3)-METHYLCYTIDINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Mettl2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
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    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Methyltransferase type 12" evidence="7">
        <location>
            <begin position="209"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR037755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005022361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="415" mass="48288" checksum="DCBE8F079A4CF594" modified="2022-01-19" version="1">MNFITRLSALCLSKKNNMQQRHQSSRRPAVPLGSRILTDPSKVFEHNMWDHMQWSQEEEERAKEKAAENSLVKVQLEDQDKYEREASKYWNEFYKTHKNNFFKDRNWLFLEFPEILPEKLREQLKIEERPSEHTKINITSSFSQKKEMFEEGEKYWKKNIGDDSTSGKGYISNKKQSISIADSPRGKNNEEEVNVRESFPGSHATYRILEVGCGAGNSVFPILKVLCNTPGTFLYCCDFASGAVELVKSHSSYNSAWCSAFVHDVCDDALPYPFPDEILDVILLVFVLSTIHPDRMQQVVNRLVKLLKPGGMLLFRDYGRYDTAQLRFKKGHCLSENFYVRGDGTRVYFFTKEEVRNVFNLAGLTEVQNLLDRRLQVNRKKKVKMLRVWVQGKFQKPLLLSINSPEETTKRHPYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U615</accession>
    <name>A0A8C2U615_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U615"/>
    <dbReference type="Ensembl" id="ENSCJPT00005031546.1">
        <property type="protein sequence ID" value="ENSCJPP00005023018.1"/>
        <property type="gene ID" value="ENSCJPG00005018292.1"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029133">
        <property type="entry name" value="OCC1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15506">
        <property type="entry name" value="OCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005023018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="74" mass="7491" checksum="297BE9EA15861716" modified="2022-01-19" version="1">ICFPLSSLSSAGTGWSDKAASHSPQGKGALNYGGVYVGLPSDAAAVVSSQTKAASKGIERSCIAFLLLSWLSCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U7F9</accession>
    <name>A0A8C2U7F9_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gem nuclear organelle associated protein 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">GEMIN8</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015703940.1">
        <property type="nucleotide sequence ID" value="XM_015848454.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015703945.1">
        <property type="nucleotide sequence ID" value="XM_015848459.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U7F9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005031375.1">
        <property type="protein sequence ID" value="ENSCJPP00005022892.1"/>
        <property type="gene ID" value="ENSCJPG00005018193.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107305836"/>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="C:SMN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034754">
        <property type="entry name" value="GEMIN8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16238">
        <property type="entry name" value="GEM-ASSOCIATED PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16238:SF7">
        <property type="entry name" value="GEM-ASSOCIATED PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15348">
        <property type="entry name" value="GEMIN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="78"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005022892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="234" mass="28477" checksum="B6E824F61B8E7E7F" modified="2022-01-19" version="1">MEQTPQEMEETEPWYFQKMYARYWKHYDLAMRWMRRHQEAYRKAMESLCHVPWPPYAASPSSRYSDWDGDDPSCTHNHFFNYGPHGRAQRRMDAQPRKEHDDREEEEEDSEVEEDSESEGEFEYDLSNMEITEELRQFFAQTERHREELRRQQQLEAEQQEMYVEADQDLYRNTKRSVEPPAERPGERRMAEMEKLYGDEAAKILAMETAMQLIFDRNCDKKQPKYWPIIPLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U7V8</accession>
    <name>A0A8C2U7V8_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pancreatic polypeptide</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the NPY family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2U7V8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005033406.1">
        <property type="protein sequence ID" value="ENSCJPP00005024522.1"/>
        <property type="gene ID" value="ENSCJPG00005019316.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000185319"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005184">
        <property type="term" value="F:neuropeptide hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031841">
        <property type="term" value="F:neuropeptide Y receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007631">
        <property type="term" value="P:feeding behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007218">
        <property type="term" value="P:neuropeptide signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00126">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001955">
        <property type="entry name" value="Pancreatic_hormone-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020392">
        <property type="entry name" value="Pancreatic_hormone-like_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10533">
        <property type="entry name" value="NEUROPEPTIDE Y/PANCREATIC HORMONE/PEPTIDE YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10533:SF5">
        <property type="entry name" value="PRO-NEUROPEPTIDE Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00159">
        <property type="entry name" value="Hormone_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00278">
        <property type="entry name" value="PANCHORMONE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00309">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00265">
        <property type="entry name" value="PANCREATIC_HORMONE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50276">
        <property type="entry name" value="PANCREATIC_HORMONE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0027">Amidation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034901194" description="Pancreatic polypeptide" evidence="6">
        <location>
            <begin position="34"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005024522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="88" mass="9803" checksum="E3F06FED44872F99" modified="2022-01-19" version="1">MLHCCIAAMQPRWASMLLLLCSLLLLHAPPCSAGPSQPIYPGDDAPVEELIRFYNDLQQYLNVVTRHRYGRRSSSRVLCEEPMGAAGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U833</accession>
    <name>A0A8C2U833_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Opticin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">OPTC</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015740848.1">
        <property type="nucleotide sequence ID" value="XM_015885362.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U833"/>
    <dbReference type="Ensembl" id="ENSCJPT00005032771.1">
        <property type="protein sequence ID" value="ENSCJPP00005023985.1"/>
        <property type="gene ID" value="ENSCJPG00005018959.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005032772.1">
        <property type="protein sequence ID" value="ENSCJPP00005023986.1"/>
        <property type="gene ID" value="ENSCJPG00005018959.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107324915"/>
    <dbReference type="KEGG" id="cjo:107324915"/>
    <dbReference type="CTD" id="26254"/>
    <dbReference type="GeneTree" id="ENSGT00940000154248"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001525">
        <property type="term" value="P:angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061975">
        <property type="term" value="P:articular cartilage development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060348">
        <property type="term" value="P:bone development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030199">
        <property type="term" value="P:collagen fibril organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016525">
        <property type="term" value="P:negative regulation of angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000372">
        <property type="entry name" value="LRRNT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043547">
        <property type="entry name" value="Mimecan/Epiphycan/Opticin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46269">
        <property type="entry name" value="EPIPHYCAN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46269:SF4">
        <property type="entry name" value="OPTICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00013">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044679406" evidence="10">
        <location>
            <begin position="26"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="LRRNT" evidence="11">
        <location>
            <begin position="133"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005023985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="338" mass="37953" checksum="3078E32040349C81" modified="2022-01-19" version="1">MALGHRMQTLAWVGIASLCLGATWAVPAKKERKKVEKPKADLVLYENLDLDNYDVTLDSYGDIMDLNNYEELYDYGDLVPKIEVGTLAPRPKDRKALPELGTAAPAPKLQPLATTNPIHPAPPGPGTVQGLPSCLRCLCIRTSVYCDDTDLEHIPPLPPDTTYLYARFNRISAIRAGDFMGLKKLKRIDLTSNSISWADADAFRHLSSLQELILPENRLTALPELPRSIIRLDARLNRISSAGLRPEAFQDLKQLQFLHLSDNQLDYIPAPLPESLRSLHLQNNNIQTMHEDTFCNSQDQSHIRRALEDIRLDGNPINLSLFPNAYFCLPRLPTGRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U9I4</accession>
    <name>A0A8C2U9I4_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein disulfide isomerase like, testis expressed</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">PDILT</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2U9I4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005031937.1">
        <property type="protein sequence ID" value="ENSCJPP00005023288.1"/>
        <property type="gene ID" value="ENSCJPG00005018501.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160939"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008354">
        <property type="term" value="P:germ cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007286">
        <property type="term" value="P:spermatid development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02995">
        <property type="entry name" value="PDI_a_PDI_a'_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02982">
        <property type="entry name" value="PDI_b'_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02981">
        <property type="entry name" value="PDI_b_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000167">
        <property type="entry name" value="Protein disulfide isomerase like, testis expressed"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929">
        <property type="entry name" value="PROTEIN DISULFIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929:SF58">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE-LIKE PROTEIN OF THE TESTIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="278"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005023288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="419" mass="48171" checksum="250C0316CEBA1636" modified="2022-01-19" version="1">QNASKEFAEAARLLKKEAPRIQFGKIDVTDQHDLRKEFNIQEFPTVKFFVDGIREAPIDCKGKLSYALLMAGRADLFSFITWIKRQTGPSTVLINSTHQVEAIINADDLAVIGFFKELHGDSVEVFRETAKDVPEMPFGMTSSEDIRAHYGIQLNALVVFKKVGVQMEQMLSVVFQTSVKIFDVPVENHILLFIPTSSKTFNTTYENYKSAAAEFRGKIMFVLVNTNETRNGRIFEYFRIREVDVPAVRILNLTSQEKYKMPADEVTVENIRQFCQSYLDGKAKLHLSSEEVAEDWDKMPVKVLVGKNFNRIVFNRTTTVFVMFYAPWSYECRKLLPIWDELGEKYQSHEDVIIAKIDITANDVLSVEMDRYPFFRLFPAGPNIQVPYAGEHNLEAFSEFLEEQMKMKAETREKVGDND</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U9X5</accession>
    <name>A0A8C2U9X5_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U9X5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005033451.1">
        <property type="protein sequence ID" value="ENSCJPP00005024565.1"/>
        <property type="gene ID" value="ENSCJPG00005019346.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000172611"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005024565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="39" mass="4275" checksum="5DC7BA595D6AF15E" modified="2022-01-19" version="1">MADLAALEELAKLEYLSLVSKVCTELDNHLGINDKDLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UBW5</accession>
    <name>A0A8C2UBW5_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NHL repeat-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">NHLRC2</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Required for normal embryonic development.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015722779.1">
        <property type="nucleotide sequence ID" value="XM_015867293.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UBW5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005034764.1">
        <property type="protein sequence ID" value="ENSCJPP00005025564.1"/>
        <property type="gene ID" value="ENSCJPG00005020062.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107316120"/>
    <dbReference type="KEGG" id="cjo:107316120"/>
    <dbReference type="CTD" id="374354"/>
    <dbReference type="GeneTree" id="ENSGT00390000015483"/>
    <dbReference type="OrthoDB" id="273823at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd14951">
        <property type="entry name" value="NHL-2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03012">
        <property type="entry name" value="TlpA_like_DipZ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000063">
        <property type="entry name" value="NHL repeat containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000068">
        <property type="entry name" value="NHL repeat-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000108">
        <property type="entry name" value="NHL repeat-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045302">
        <property type="entry name" value="NHL2_NHL_rpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46388">
        <property type="entry name" value="NHL REPEAT-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46388:SF2">
        <property type="entry name" value="NHL REPEAT-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01436">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13905">
        <property type="entry name" value="Thioredoxin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Thioredoxin" evidence="7">
        <location>
            <begin position="38"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00057428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00071348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005025564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="727" mass="79478" checksum="24A9278CD4205EE3" modified="2022-01-19" version="1">MAAEGLAGLLPSQTQLEYALLDADSPQEKENLVYQYLKKMDSRERDLTAPELGGDLQWLNTEGPISLHKDLCGKVVVLDFFTYCCINCLHLLPDLHELEHQYSDKDGLVIIGVHSAKFPNEKVLDNIKSAVLRYDIGHPVVNDADATLWHELEVSCWPTLVILGPRGNMLFSLVGEGHKEKLFLFTSITLKFYKERGQIKDNSIGIKLYKDSLPPSPLLFPGKVTVDKSGERLVIADTGHHRILVTLKNGQILHTIGGPNSGRKDGRFSEAAFNSPQGVAIKNNVIYVADTENHLIRKIDLELEIVTTVAGIGIQGVDKEGGAKGEEQPISSPWDVVFGSSVSGTQEDDVLWIAMAGIHQVWALMLEGGKLPKGSDLKKGVCLRFAGSGNEENRNNAYPHKAGFAQPSGLSLAPEEPWNCLFVADSESSTVRMISLKDGAVKHLVGGERDPLNLFAFGDVDGAGINAKLQHPLGVTWDKKRKLLYVADSYNHKIKVIDPKMKNCATLAGTGEATNVLGSSFTQSTFNEPGGLCIEENGRLMYVADTNNHQIKVLDLETKVLSMLPILNPESRDVTDHPSVQKDQIANLPKLPKSAPNIQLPSLSAAPGQTIQFLLKLTLPPDSKLNEEAPNAWFITAEDNNTWLLQGQHLSGEIKDVSCQTVIPFQLPRVCLSAEAVLAIKACLYYCSKDSSACMMKGISFNQPLQIGSTNQGSLTQVELTHSFITN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UH19</accession>
    <name>A0A8C2UH19_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Solute carrier family 35 member F5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">SLC35F5</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Putative solute transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC35F solute transporter family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015724469.1">
        <property type="nucleotide sequence ID" value="XM_015868983.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015724470.1">
        <property type="nucleotide sequence ID" value="XM_015868984.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015724471.1">
        <property type="nucleotide sequence ID" value="XM_015868985.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015724472.1">
        <property type="nucleotide sequence ID" value="XM_015868986.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015724473.1">
        <property type="nucleotide sequence ID" value="XM_015868987.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UH19"/>
    <dbReference type="Ensembl" id="ENSCJPT00005035580.1">
        <property type="protein sequence ID" value="ENSCJPP00005026263.1"/>
        <property type="gene ID" value="ENSCJPG00005020446.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107316927"/>
    <dbReference type="KEGG" id="cjo:107316927"/>
    <dbReference type="CTD" id="80255"/>
    <dbReference type="GeneTree" id="ENSGT00390000005949"/>
    <dbReference type="OrthoDB" id="10041630at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23051:SF0">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23051">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35, MEMBER F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="280"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="309"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="338"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="374"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="403"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005026263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="504" mass="56949" checksum="69746765EB298546" modified="2022-01-19" version="1">MVWVFIMNRMSSQSSSSSQRRRMALGIVILLLVDVIWVASSELTSYVFTKYNKPFFSTFAKTSMFVLYLLGFIVWKPWRQQCTRGFRGRHAAFFADAEGYFAACTTDNAVNSSLLERNGLPSFQWMKCCSSLNQMPVLSEPLYVPVKFHDLPTEKSGSNNNDTEKTPKKPRVRFSNIMEIRQLPSSHALEAKLSRMSYPAVKEQESILKTVGKLTATQVAKISFFFCFVWFLANFSYQEALSDTQVAIVNILSSTSGLFTLILAAVFPSNSGDRFTLSKLLAVFLSIGGVVLVNLSGSEKSPGRDTIGSLWSLVGAMLYAVYIVMIKRKVDREDKLDIPMFFGFVGLFNLLLLWPGFFLLHYTGFEAFEFPSKLIWMCIVINGLIGTVLSEFLWLWGCFLTSSLIGTLALSLTIPLSIIADMCMQKVQFSWLFFAGAVPVFFSFFIVTLLCHYNNWDPVMVGIRRVFAFICRKHRIQRMPEESEQCESLIPMHSVSQDGDSCCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y7C7</accession>
    <name>A0A8C2Y7C7_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Interferon lambda receptor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">IFNLR1</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015738823.1">
        <property type="nucleotide sequence ID" value="XM_015883337.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y7C7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005008729.1">
        <property type="protein sequence ID" value="ENSCJPP00005005361.1"/>
        <property type="gene ID" value="ENSCJPG00005005151.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107323880"/>
    <dbReference type="KEGG" id="cjo:107323880"/>
    <dbReference type="CTD" id="163702"/>
    <dbReference type="GeneTree" id="ENSGT00510000048978"/>
    <dbReference type="OrthoDB" id="7680836at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004896">
        <property type="term" value="F:cytokine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015373">
        <property type="entry name" value="Interferon/interleukin_rcp_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050650">
        <property type="entry name" value="Type-II_Cytokine-TF_Rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20859:SF55">
        <property type="entry name" value="INTERFERON LAMBDA RECEPTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20859">
        <property type="entry name" value="INTERFERON/INTERLEUKIN RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09294">
        <property type="entry name" value="Interfer-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01108">
        <property type="entry name" value="Tissue_fac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034215663" evidence="3">
        <location>
            <begin position="23"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="226"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="26"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005005361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="566" mass="64330" checksum="CA6EF62AA1F2E0E7" modified="2022-01-19" version="1">MSAWRISALAVLCLLWQPRGHGQLPPPQNVTLQSKDFDMILTWTPGEGSPPDVLYTVRYESKARMDKWIKVPHCRNIHSNSCNLTCVIPNFFIKFRAQVKATSGRLHSPWVTSQFKEYHLDVELAPPLLNVNVKENVIHVNATFPMALCVESLSWMYDFNFWEAGSENKKQYKSIFRKKAVTIDTTALRGNYCLNARSSIQSIDFKHSKFSQPVCVVLNQQGEWRFPFSAVIPVCVLLVLLTSVSTIWLLKQDVKHKQMPQALDISNCKTAGPTFCCELRENEFLTDCLICTEKPMSQGKKNKTLARNNRLWMASFLPSSSEEDEEEEEEDSSSFIPYTEMLQFPGRHFNFQTYRTADAETILDFTSGGLSVDGGSTLDLSAVGFSFFPMKKNEVDTSGSQGNEKASHSHSSSLGRISLTDVRFPGPREHGQHDTDSDDCLEVSLLHTPVNRSCTRLPADEHCLYTKDHEFTIHCLKPTLDQPVQVSENSLLNEDLSMEKLIYFQTLQVAEDEGIASDCDSDNFTDRTPPASMVLSEALRTSDMEKRYDKMFKFKGYQHSHYMRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y8K0</accession>
    <name>A0A8C2Y8K0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17 18">Receptor-type tyrosine-protein phosphatase alpha</fullName>
            <ecNumber evidence="4 18">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">PTPRA</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Tyrosine protein phosphatase which is involved in integrin-mediated focal adhesion formation. Following integrin engagement, specifically recruits BCAR3, BCAR1 and CRK to focal adhesions thereby promoting SRC-mediated phosphorylation of BRAC1 and the subsequent activation of PAK and small GTPase RAC1 and CDC42.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Focal adhesion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the protein-tyrosine phosphatase family. Receptor class 4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="4 18"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y8K0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005012667.1">
        <property type="protein sequence ID" value="ENSCJPP00005008327.1"/>
        <property type="gene ID" value="ENSCJPG00005006905.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159585"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd14621">
        <property type="entry name" value="R-PTPc-A-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000007">
        <property type="entry name" value="Receptor-type tyrosine-protein phosphatase alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000021">
        <property type="entry name" value="Receptor-type tyrosine-protein phosphatase alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016336">
        <property type="entry name" value="Tyr_Pase_rcpt_a/e-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027262">
        <property type="entry name" value="Tyr_Pase_rcpt_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF433">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500808">
        <property type="entry name" value="PTPR_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002006">
        <property type="entry name" value="PTPR_alpha_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0965">Cell junction</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 21" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11 18" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="7 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="23">
        <location>
            <begin position="261"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="24">
        <location>
            <begin position="441"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="23">
        <location>
            <begin position="553"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="24">
        <location>
            <begin position="722"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="205"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="19">
        <location>
            <position position="462"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="19">
        <location>
            <position position="747"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="430"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="462"/>
            <end position="468"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="506"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="Phosphotyrosine" evidence="21">
        <location>
            <position position="813"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00054255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00074216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR002006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR002006-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR002006-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR002006-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005008327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="817" mass="93392" checksum="061373CAD0DD33E8" modified="2022-01-19" version="1">MCEHTDKSFHPCAYSDSIHVFTRPFQLYTAKLVWDNTSNKWCFLFCSFSQVNMDLCFFVLLLGSGLISIGANNVTTGKPCLLSPILPLNHLEGGRKKCSCSCDSPLLLAVLQGWQTVGHPVQPDNATLWNKWVILKAGSVEEWPSDGTGWFWIDVGSSYPHPSFFVADETPIIAVMVALSSLLVIVFIIIVLYMLRFKKYKQAGSHSNSFRLPNGRTDDAEPQSMPLLARSPSTNRKYPPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDVTNKKPQRLVTQFHFTSWPDFGVPFTPIGMLKFLKKVKTCNPQYAGAIVVHCSAGVGRTGTFIVIDAMLDMMHAERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLEIHLQKIYNKVPGTSSNGLEEEFKKLTSIKIQNDKMRTGNLPANMKKNRVLQIIPCKLCLSVQLKEEWRKTDYVNASFIDGYRQKDSYIASQGPLQHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGSVSYGDINVELKKEEECESYTVRDLLVTNTRVRIRQFHFHGWPEVEIPSDGKGMINIITAVQKQQQQSGNHPITVHCSAGAGRTGTFCALSTVLEIVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDAFSDYANFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y8T5</accession>
    <name>A0A8C2Y8T5_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">RAR related orphan receptor B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">RORB</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015704638.1">
        <property type="nucleotide sequence ID" value="XM_015849152.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y8T5"/>
    <dbReference type="SMR" id="A0A8C2Y8T5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005013295.1">
        <property type="protein sequence ID" value="ENSCJPP00005008819.1"/>
        <property type="gene ID" value="ENSCJPG00005007829.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107306211"/>
    <dbReference type="KEGG" id="cjo:107306211"/>
    <dbReference type="CTD" id="6096"/>
    <dbReference type="GeneTree" id="ENSGT00940000157708"/>
    <dbReference type="OrthoDB" id="8832025at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome Z"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008502">
        <property type="term" value="F:melatonin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004879">
        <property type="term" value="F:nuclear receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045668">
        <property type="term" value="P:negative regulation of osteoblast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042752">
        <property type="term" value="P:regulation of circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046549">
        <property type="term" value="P:retinal cone cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046548">
        <property type="term" value="P:retinal rod cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd06968">
        <property type="entry name" value="NR_DBD_ROR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06939">
        <property type="entry name" value="NR_LBD_ROR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.565.10:FF:000005">
        <property type="entry name" value="Nuclear orphan receptor ROR-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000003">
        <property type="entry name" value="Nuclear orphan receptor ROR-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044101">
        <property type="entry name" value="NR_DBD_ROR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003079">
        <property type="entry name" value="ROR_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45805">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR HR3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45805:SF6">
        <property type="entry name" value="NUCLEAR RECEPTOR ROR-BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01293">
        <property type="entry name" value="RORNUCRECPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="13">
        <location>
            <begin position="7"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="14">
        <location>
            <begin position="211"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="93"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005008819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="459" mass="52172" checksum="B4A6E2A760E36A79" modified="2022-01-19" version="1">MRAQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQNNASYSCPRQRNCLIDRTNRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLYAEVQKHQQRLQEQRQQQSGEAEALARVYSNSISNGLGNLNNETGSTYSNGHVIDLPKSEGYYNVDSAQPSPDQSGLDMTGIKQIKQEPIYDLTSVPNLFTYSSFNNGQLAPGISMTEIDRIAQNIIKSHLETCQYTMEELHQLAWQTHTYEEIKVYQSKTREALWQQCAIQITHAIQYVVEFAKRITGFMELCQNDQILLLKSGCLEVVLVRMCRAFNPLNNTVLFEGKYGGMQMFKALGSDDLVNEAFDFAKNLCSLQLTEEEIALFSSAVLISPDRAWLIEPRKVQKLQEKIYFALQHVIQKNHLDDETLTKLIAKIPTITALCNLHGEKLQVFKQSHPDIVNTLFPPLYKELFNPDSTTGCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y8X0</accession>
    <name>A0A8C2Y8X0_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ALMS1 centrosome and basal body associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ALMS1</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="Ensembl" id="ENSCJPT00005013124.1">
        <property type="protein sequence ID" value="ENSCJPP00005008688.1"/>
        <property type="gene ID" value="ENSCJPG00005007741.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153123"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046599">
        <property type="term" value="P:regulation of centriole replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029299">
        <property type="entry name" value="ALMS_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21553">
        <property type="entry name" value="ALMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21553:SF22">
        <property type="entry name" value="CENTROSOME-ASSOCIATED PROTEIN ALMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15309">
        <property type="entry name" value="ALMS_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ALMS motif" evidence="5">
        <location>
            <begin position="2459"/>
            <end position="2591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="42"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
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            <begin position="99"/>
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    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="689"/>
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    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="793"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="865"/>
            <end position="924"/>
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    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="950"/>
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    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="982"/>
            <end position="1014"/>
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    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1109"/>
            <end position="1149"/>
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        <location>
            <begin position="1416"/>
            <end position="1441"/>
        </location>
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        <location>
            <begin position="1526"/>
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        <location>
            <begin position="1737"/>
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            <begin position="2435"/>
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            <begin position="42"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="4">
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            <begin position="2297"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF15309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005008688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="2595" mass="285452" checksum="32239A4CAA29BCEB" modified="2022-01-19" version="1">MGDKAMNQMEAALAKQTYGTSVEDERFTCDNNVLTPVFELSEKEKELSGHDEFSSSENSSCKTALTKNSGKSEREMQMERVKMAGSESAGCLRHPERMEKEGAPELGSSKTLSDDLKKSSCKNSGARDVFSAKTSEITGESKECQVDLNGFGSMKFVAVTNELRGAFLEKQGLREQELSPIVPSTGDSAPKQLVMTDMESPPSCSGNARVEVEPGVHKAELTISDVSIERGHKVTGISPSLNFIVDDGSFFRHFSHPNYQSTPGVLLNKNVKAELGAHVVKSGGQASPLCLNEDNCGNSTTSTPTSVEKQRSLQCAQKENSKRFDSLKLKYPHTGRIQSLPSLNFMEKVDTWNMSQPENTSDALASCYQNVISHRKKAYSAVAISANNIFSMQNSSRNPKDYVAVPSGEKHSLENIHFHNKSSERFHPLTRSQSDNSVNVVRKDNSQADVVQPVNEAMQPLESNVSGVPENSSGGSLMHKLTTEVASGSVDKGAEGNSMGQSSYPNAFVSSERVSHLIKEDGSSSTDTQKKCDGLENQRLSHNLDVGHVRKDNFADTSPDNPNLPACSGALGSPGCSSVVTRHFFTGAEGDNIISVRATTVLETPEKEELNIEERIPIYLRNLGIDQSPGTILTPFVPRGPIREVEFSPSDLRTLKDSTDTLTRTIQQPQGELLAAVDVVQTSFNSDTSTASISIPMNSETDSDTFSPGELSSRFSLPFGAKPVSQCTMSCHKVEVTSPLSTQRETECSAVSKLAEPSQHLQTVPPDCHSNRESPVLVAKSVQGLLAKKESKDASGSSWGWTASSLAGVTDEKERGSQTSSAESEKNKGQESDCLLGSGALQEIRKLLAEAESIAGRWRDPVFSNASSRETQSSPVQIEKEDDTRDSKLVKDSIPQFQKVVSRAESMSQRSIQEGSITKPMDSCKDDLKWERSFDVGLCSREGMEMTREFRTGKSVGRSEPEGCSSITTDRNLPAVVAVAQSNANSELSTRRPSELEEPSPSEPRESVIDVPGSFQNKLSKADVAVNTAGGIRESSGSNSGDSLAAHVKNLLGNPLISLGNTADISGGFQSMMSKTSAAGSKAGGVQDSDGSSSGDSLAARVKNLLRGPSETLGSTTDAPGGFQSVLSKPSVAGSKAGGVQESDGSSSADSLAARVKSLLRNGSPLMPAVPVLKSANEEEWKARAWVKLKLASRSQEAVLDLNEEDRQRIEEIKAELLLSAKKSGQAKGTRSYSSEAASVYSYNQEADKVHSKASSDKRFRSDSQTQAFKTKELLMPSLQRVVPLYRAELSDSCLLKNTQLKSLSTAEPPACSQHQAIASSHSDCVGLQLPLQKQQDTRVMSSAAASGALTGKVPSPAQKKLSFPKCSEEMSKQITSITFSSRKRFQSPLSSVVHDGFSSGDDLDGIMPLEIDSATAEEQSRDKHHWERSETCPLSSPALAGSRSNEIAFTADKDRFCDVSDGNRAGADQETDFLSDRESVTVYADERQTLSAKNLDASSQNVTELGRHSARLLGLDCERRFSQSMKGLHEPRSISPYQKEKSSPTSHVQLRESLEGSDPAIQTDLPKDHGKLLEEEKCPSDAVPLIQKEDSGEQIGASQHSSPDEILCTVSPSSPIKKALSCVHITLSPKCNNSELHRDLNTENRMSLGDKLEVNSQPVPLKTPETLLEALPKLPTADLIPEDQRCSSFPVPSADPCSVFYSVPSTAGQELPLHGSEKPQAVSSEGHSLKNICNCTDPAKSRKSTSDATTQITTESPGKTTFSAEIYVNSQDIESSAHQSSTQKAKEFPQNTTSCLNRTSSFPRQGGQPLLLPYKPSGSTEMYYVPYLKAGTKISLLGTENSGPHDALPSGLPANVLGMQDNAPDSTAIKHKEGVYCKRAKPKLAWAEEQTIAQEGAPEGSHHLKSVNTTHSGFKSAQFYLHHPVSMREKYLLSHSEPSEDSSGVGHTGISSSTAVRNWKKAHRHRWVFSAHHRKDDKREFFPLTAEADYSKNEDLNVDTSLNNEAPREELLQPGGREAEQMAAYSQTSHLRENVVKDLPPRHRTHSAGSLDELWVKFLERQKRYQQHEFRHKGELTLVERLDRLARVLQNPVRYTLISAKAERNASEETDEVKEQEKRRLLEKSVAESTLEPHAARVKERPRINCHERSFVELRKNRSEEKVTIHMHEISEHQQYLDTSSDTCSERRLSKDLCTTVSSVISESDAVTQTDIETTTQTEVSSSVSTIDTARLVRAFGHRRVQLSPRLSQLYCTIRQQKSRSEKWDEEDSRVRGVKHPNVTSERHRKQKETQALDPALTSSGSWGPSSALSNKRRSRMLNKGIQAGDLEIVNGATKRNTRDFGVTFPTPRPIQPNQRPRDPWHRVHGIFGESDGTVTDHQAAGRKGISWFVQAEDLKFESRKENCSNSIPGPGSSWFEPFTTTKPWREPLREKNFQEQQCSKVTQPAERDAETRPTRPFVKLTLQEALALHRPDFIFRSGERVKHLKLVMEERRIQSELQSEQEELFNPLEKRKGYRNANHLLDDRGYLMKEKRRAIPKSEMVQRSKRIYEQLPEVQKKREEEKRKAEYNSNRLKAQLYKMKITNRVLGRKVPWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YAJ7</accession>
    <name>A0A8C2YAJ7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">KIF9</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Essential for normal male fertility and for progressive motility of spermatozoa.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Interacts with HYDIN.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Flagellum axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15 16">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2YAJ7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005018053.1">
        <property type="protein sequence ID" value="ENSCJPP00005012469.1"/>
        <property type="gene ID" value="ENSCJPG00005010569.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158533"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002102">
        <property type="term" value="C:podosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036126">
        <property type="term" value="C:sperm flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031982">
        <property type="term" value="C:vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022617">
        <property type="term" value="P:extracellular matrix disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903008">
        <property type="term" value="P:organelle disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901317">
        <property type="term" value="P:regulation of flagellated sperm motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071801">
        <property type="term" value="P:regulation of podosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000040">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056524">
        <property type="entry name" value="KIF6/9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF62">
        <property type="entry name" value="KINESIN FAMILY MEMBER 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23735">
        <property type="entry name" value="KIF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="8 17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0282">Flagellum</keyword>
    <keyword evidence="4 16" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10 15 16" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 15 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="18">
        <location>
            <begin position="6"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="590"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="93"/>
            <end position="100"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00063408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005012469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="762" mass="87113" checksum="E7CE25B7C24F7CD9" modified="2022-01-19" version="1">MGTVRKVRAFVRVKPTAQFAQDVIKFGPDNKSIGIYIQKDAKKGTVNNSQTDWSFKLDGVLHNSSQELTYETVAKKLVSEALTGYNGTIMCYGQTGAGKTYTMTGIASEYKHRGIIPRAVQQVFRAIARSVDSFVTVRVSYLEIYNETLCDLLSTMRSSEDSDMEMAIVDCPQGVYVKGLSIHSVSDEEDALNLLFEGESNRVIAEHTLNKKSSRSHCIFTIYIESRFRVLSDDRCIHSKINLIDLAGSERLNKTGSGWRVLKEAAYINRSLSFLEQMIIALADPRREHIPFRQSKLTHFLKDSLGGKCNTVLVANVCGEALHVEETLSSLRFATRMKWITSEPVINVTYDSEGTVKALEKEISLLKQELALHDILVNHSLVTYEPLTDVQIAEIKSQIHKYLRGAIDEIDVSSFLRAVDVFCFSQRQQEGEVETRLRSKYVLIDRNDFATIAAAQKVMVGAWALPTTQFRIIFFKEIKLVYLFLSFRKEGTKHLFSGKDLTANLPPKNKVIIPTKDLDVKEKERSEDITDLPSTPCLLFEFCCSSPPSREAAFEQFKEECGSEINRIFKENKSILLARRKRSSTVARRINIIKQEIEDIKKALEAQKQERLQQGEYVDEEGHLIIDEKEFLLIMKLKDLKEEYRCSYAERQDLKAEIQYCQQMVDRCRNKLVSEFEIWYSESFLIPTYVQNALKQHGNIRPGMIPINRVMCLEEDEQDRFEQMQEVMLPYGPDSVAFYRAKMKTDQQVMSSGPNVEDFVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YBT8</accession>
    <name>A0A8C2YBT8_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prefoldin subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">PFDN1</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2YBT8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005021053.1">
        <property type="protein sequence ID" value="ENSCJPP00005014828.1"/>
        <property type="gene ID" value="ENSCJPG00005012345.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000009786"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23164">
        <property type="entry name" value="Prefoldin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000006">
        <property type="entry name" value="prefoldin subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20903:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20903">
        <property type="entry name" value="PREFOLDIN SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="165"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005014828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="210" mass="23703" checksum="913E582CA4CDE929" modified="2022-01-19" version="1">MLGEVLHIERGGAGTGCTEGLWMPHPWLCSRPGWMEPCAMYQIWRSVGWNLLLLGPLPPHPALTSIRPQPAPPRPPTAPTAQAPSVGKMAAPVDLELKKAFTELQAKVIDTQQKVKLADIQIEQLSKSKKHAHLTDTEIMTLVDETRMYEGVGRMFILQSKGVIHNQLLEKQRIAEEKIKELEQKKSYLERSVKEAEDNIREMLMARRAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YCM4</accession>
    <name>A0A8C2YCM4_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 15">Transferrin receptor protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">TFRC</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homodimer; disulfide-linked.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Cell membrane</location>
            <topology evidence="15">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Melanosome</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="15">Stearoylated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 15">Belongs to the peptidase M28 family. M28B subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015727308.1">
        <property type="nucleotide sequence ID" value="XM_015871822.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YCM4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005023277.1">
        <property type="protein sequence ID" value="ENSCJPP00005016570.1"/>
        <property type="gene ID" value="ENSCJPG00005013608.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107318226"/>
    <dbReference type="KEGG" id="cjo:107318226"/>
    <dbReference type="CTD" id="7037"/>
    <dbReference type="GeneTree" id="ENSGT01030000234598"/>
    <dbReference type="OrthoDB" id="5841748at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070062">
        <property type="term" value="C:extracellular exosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990712">
        <property type="term" value="C:HFE-transferrin receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042470">
        <property type="term" value="C:melanosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098794">
        <property type="term" value="C:postsynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004998">
        <property type="term" value="F:transferrin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990830">
        <property type="term" value="P:cellular response to leukemia inhibitory factor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060586">
        <property type="term" value="P:multicellular organismal-level iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010637">
        <property type="term" value="P:negative regulation of mitochondrial fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030316">
        <property type="term" value="P:osteoclast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030890">
        <property type="term" value="P:positive regulation of B cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043123">
        <property type="term" value="P:positive regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045830">
        <property type="term" value="P:positive regulation of isotype switching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900182">
        <property type="term" value="P:positive regulation of protein localization to nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031334">
        <property type="term" value="P:positive regulation of protein-containing complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042102">
        <property type="term" value="P:positive regulation of T cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031623">
        <property type="term" value="P:receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099072">
        <property type="term" value="P:regulation of postsynaptic membrane neurotransmitter receptor levels"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033572">
        <property type="term" value="P:transferrin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09848">
        <property type="entry name" value="M28_TfR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02128">
        <property type="entry name" value="PA_TfR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000065">
        <property type="entry name" value="Transferrin receptor 1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.40:FF:000002">
        <property type="entry name" value="Transferrin receptor protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.30:FF:000010">
        <property type="entry name" value="Transferrin receptor protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.40">
        <property type="entry name" value="Transferrin receptor-like, dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039373">
        <property type="entry name" value="Peptidase_M28B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007365">
        <property type="entry name" value="TFR-like_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036757">
        <property type="entry name" value="TFR-like_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037324">
        <property type="entry name" value="TfR1/2_PA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404">
        <property type="entry name" value="N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404:SF26">
        <property type="entry name" value="TRANSFERRIN RECEPTOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04253">
        <property type="entry name" value="TFR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47672">
        <property type="entry name" value="Transferrin receptor-like dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 15" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 15" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="13 15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14 15" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 15" id="KW-0564">Palmitate</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12 15" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="16">
        <location>
            <begin position="237"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="18">
        <location>
            <begin position="401"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="Transferrin receptor-like dimerisation" evidence="17">
        <location>
            <begin position="654"/>
            <end position="765"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005016570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="776" mass="85875" checksum="EF1DE5235D08B3B0" modified="2022-01-19" version="1">MDHARAALSNLFSVEPMSYTRFSIARQTDGDNSHVEMKLSADDEEGGDVERPEHMHASMAQPQRSGKRLCFLVIAALLLLLIGFLIGYLSYRGRMQLAARCQDGSGSCEMTPTASYLVDGEAAEEEIQGPPVIYWPQLKTMLSDRLSATRLVDSLRQRTDVSSFEAGEAEDTTMATYIHDQFNSFFLDKVWNDEHYIKLQVRGSTRNKVSVLVGESEETLETPDAYVAYSESGSVSGKPVYVNYGLKKDFETIQKSVASLNGSIVIVRAGKITLAEKVANAKEAGAAGVLMYVDSHKYGITDTLIPFGHAHLGTGDPYTPGFPSFNHTQFPPIESSGLPHIAVQTISSSAAAKLFSKMDGDSCSEDWKGGIYSCKVTTKQESKIMVKIDVNNSMKDRKILNIFGAIQGSEEPDRYVVIGAQRDSWGPGVAKAGTGTAILLELARVISDIVKNEGYKPRRSIIFASWSAGDYGAVGATEWLEGYSAMLHAKAFTYINLDAAVLGANDIKISASPLLYVLLERIMKGVKDPASNSGNLYNRVGSDWVKAVVPLGLDNAAFPFLAYSGIPVVSFGFYNKDEEYRFLGTKDDTLENLRKFNNLDALLRAAAEVAGQVALRLTHDHELFLDFGRYSEELLAYQEKFLPYIKDVQELGLTLDWLFFARGDFQRAADALRRDIENSDRENKVIRRALNDRIMKVEYDFLSPYLSPKDVPFRHVFFGKGSHTLQSLVEHLQLLKTNKNSVDLNLLKEQLALTTWTIKGAANALGGDIWDTDNEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YCR3</accession>
    <name>A0A8C2YCR3_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Coiled-coil-helix-coiled-coil-helix domain containing 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">CHCHD6</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion inner membrane</location>
            <topology evidence="9">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the MICOS complex subunit Mic19 family. Metazoan Mic25 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2YCR3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005023845.1">
        <property type="protein sequence ID" value="ENSCJPP00005017061.1"/>
        <property type="gene ID" value="ENSCJPG00005013964.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000000903"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007964">
        <property type="entry name" value="MIC19/MIC25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042860">
        <property type="entry name" value="MIC25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47609">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47609:SF1">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05300">
        <property type="entry name" value="MIC19_MIC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="42"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="99"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="198"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="112"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="131"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005017061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="308" mass="33942" checksum="A16D05062E009A12" modified="2022-01-19" version="1">MSLAGINGACFRSSIHTIGRLGAVRQWDPVMLAGAGRGEELLGAAGRGGGVEASPRAAPPAMGGSESSQGGRKVSFGLDERDQVRVLQGIRLTEDVVNRMKESQSKRGSQRSPYSSSGTAPSSTAAEGKPKSSTGIQPPGNSDQKATVAEQELYRRYEQEQALVQEELLRLAKREREAAGEMLSTALQREWNSTNEERNRAAQLAMELQGREAELKRQEAFYKEQLARIERKNAEIYKLTSEQYQEAATKAEEMIKRRNTDPVCASLQSEILKCYQENQREVLKCSELAKEYQRCVSAAQKELLVNSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YDL6</accession>
    <name>A0A8C2YDL6_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cathepsin S</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">CTSS</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2YDL6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005025922.1">
        <property type="protein sequence ID" value="ENSCJPP00005018658.1"/>
        <property type="gene ID" value="ENSCJPG00005015187.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155176"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045335">
        <property type="term" value="C:phagocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005518">
        <property type="term" value="F:collagen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001968">
        <property type="term" value="F:fibronectin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043236">
        <property type="term" value="F:laminin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043394">
        <property type="term" value="F:proteoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019886">
        <property type="term" value="P:antigen processing and presentation of exogenous peptide antigen via MHC class II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034769">
        <property type="term" value="P:basement membrane disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097067">
        <property type="term" value="P:cellular response to thyroid hormone stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030574">
        <property type="term" value="P:collagen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002577">
        <property type="term" value="P:regulation of antigen processing and presentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010447">
        <property type="term" value="P:response to acidic pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034464371" evidence="3">
        <location>
            <begin position="23"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="5">
        <location>
            <begin position="32"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="4">
        <location>
            <begin position="117"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005018658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="293" mass="32785" checksum="B3EBF9269E3DE0CF" modified="2022-01-19" version="1">GWGLRCLLCCVAVLLSLLAVMGHPDPTLDWHWQLWKKTHGKQYRHQAEEGQRRVTWEKNLRLVMLHNLEHSMGLHSYQLGMNHMADMSSEDVAALLTGLRVPYGHRQTSRYRQRGAAPDAMDWREKGCVTEVKNQVGQIKANNGVVKVKGLKHLKVSSSPGGFHPFLLFPQNGTCQYNVSTRAATCSKYVELPYADEAALKDAVANVGPISVAIDAAQPTFFLYRSGVYDDPLCTQEVNHGVLVVGYGTLNEKDFWLVKNSWGERFGDGGYIRMARNHSNHCGIASYASYPQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YE60</accession>
    <name>A0A8C2YE60_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Calcyphosine 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">CAPS2</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YE60"/>
    <dbReference type="Ensembl" id="ENSCJPT00005027601.1">
        <property type="protein sequence ID" value="ENSCJPP00005019978.1"/>
        <property type="gene ID" value="ENSCJPG00005016140.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159670"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051581">
        <property type="entry name" value="Ca-bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34524">
        <property type="entry name" value="CALCYPHOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34524:SF3">
        <property type="entry name" value="CALCYPHOSIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="148"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="184"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005019978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="317" mass="36326" checksum="B0FED2F537D350BC" modified="2022-01-19" version="1">MLFNFPSRNGRDACRDLIGFFFACDRSLTVYEFRQFGKNRTNALPFIQKGVYKHQRGKKKGKAYDLSDFYIGANLTFQSVDHSLPKSVKQNPILTLRVIGIDEVAMDFLKDSSLQFNQESSEQLTDDSRVFRKIQGMLRKTLSKRGVRVVTGLGKYFRHIDKNGIGFLSQADFKEALKLFHLEVPEQDFESLWLILDDNKSGKVNYGEFVHAIAGEMNEYRKAFVRKAYMKLDFNKTGSIPMVDIRKCYCAKKHPLVLAGKATEEEIKSSFLETLEESCSNPGEVSYSEFEDYYEGLSIGIADDDDFVNILRNPWGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YEN9</accession>
    <name>A0A8C2YEN9_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">TSPAN7</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">May be involved in cell proliferation and cell motility.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the tetraspanin (TM4SF) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015740094.1">
        <property type="nucleotide sequence ID" value="XM_015884608.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YEN9"/>
    <dbReference type="SMR" id="A0A8C2YEN9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005028931.1">
        <property type="protein sequence ID" value="ENSCJPP00005021024.1"/>
        <property type="gene ID" value="ENSCJPG00005016849.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107324517"/>
    <dbReference type="KEGG" id="cjo:107324517"/>
    <dbReference type="CTD" id="7102"/>
    <dbReference type="GeneTree" id="ENSGT00940000156153"/>
    <dbReference type="OrthoDB" id="9972904at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03161">
        <property type="entry name" value="TM4SF2_6_like_LEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1450.10:FF:000003">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000301">
        <property type="entry name" value="Tetraspanin_animals"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018503">
        <property type="entry name" value="Tetraspanin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048232">
        <property type="entry name" value="TSN6/7_LEL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF257">
        <property type="entry name" value="TETRASPANIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002419">
        <property type="entry name" value="Tetraspanin"/>
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    </dbReference>
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        <property type="entry name" value="TMFOUR"/>
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    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TM4_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="90"/>
            <end position="112"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="215"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
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            <begin position="151"/>
            <end position="174"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00056010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR002419-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005021024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="249" mass="27608" checksum="F4E96FA399FE6EAD" modified="2022-01-19" version="1">MASRRMETKPVITCLKTLLIIYSFVFWITGVILLAVGVWGKLTLGTYISLIAENSTNAPYVLIGTGTTIIVFGLFGCFATCRGSPWMLKLYAMFLSLVFLAELVAGISGFVFRHEIKDTFLRTYTEAIQNYNKNDERSHAVDNVQESLSCCGIQSYTNWSTSPYFFKHGIPTSCCMNSSDCNTQDLRNMTVAATKVNQKGCYDLVTSFMETNMGIIAGVAFGIAFSQLIGMLLACCLSRFITANQYEMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YF66</accession>
    <name>A0A8C2YF66_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bone marrow proteoglycan-like</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YF66"/>
    <dbReference type="Ensembl" id="ENSCJPT00005030187.1">
        <property type="protein sequence ID" value="ENSCJPP00005022009.1"/>
        <property type="gene ID" value="ENSCJPG00005017585.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
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        <property type="entry name" value="C-type_lectin-like/link_sf"/>
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        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="C-type lectin-like"/>
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    </dbReference>
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        <property type="entry name" value="C_TYPE_LECTIN_1"/>
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        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="199"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005022009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="247" mass="27123" checksum="F563E78B74C4E136" modified="2022-01-19" version="1">MGWPVGVGEPRTVWPLAQGHFPSLQSWCPQQPIAVVGPRCHHPLGQPCDSVSVSCHALSPQGDAPNILQALLYLGMHSGTLLSPVSGYWCWRGCRGDTLQPVPSLSPVAHHEGTCRQRGGQREALCSGEDMAHLQQCPGERGGEVSGMPGSHGHCQCQALTCAPQSYCRNTYRGQLASVHSTSTNEVLRKLNGSWKTCWEDQSPWNYANWATGQPQRLFKTCTVLSPKDGLWRSKACFKIRPFICEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YH92</accession>
    <name>A0A8C2YH92_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="13">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">EDEM1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. It is directly involved in endoplasmic reticulum-associated degradation (ERAD) and targets misfolded glycoproteins for degradation in an N-glycan-independent manner, probably by forming a complex with SEL1L. It has low mannosidase activity, catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="13"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2YH92"/>
    <dbReference type="Ensembl" id="ENSCJPT00005035759.1">
        <property type="protein sequence ID" value="ENSCJPP00005026416.1"/>
        <property type="gene ID" value="ENSCJPG00005020536.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157717"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016235">
        <property type="term" value="C:aggresome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044322">
        <property type="term" value="C:endoplasmic reticulum quality control compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904380">
        <property type="term" value="P:endoplasmic reticulum mannose trimming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904154">
        <property type="term" value="P:positive regulation of retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006986">
        <property type="term" value="P:response to unfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000016">
        <property type="entry name" value="alpha-1,2-Mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044674">
        <property type="entry name" value="EDEM1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45679:SF5">
        <property type="entry name" value="ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45679">
        <property type="entry name" value="ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0834">Unfolded protein response</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="92"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="380"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="484"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="503"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="589"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00060207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005026416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="661" mass="74021" checksum="CFE8CEA505CDAE96" modified="2022-01-19" version="1">MSAARPRPPRASSNAEFSVSLPPSQQPRLGRAARRNYARGARATMQWRSVVLGLLLLRLALHALLALLPALGPGFCLRLRLPFPFPPRSAALGPPGSSRPPPGGVSSHWGSLRGGAGAAGRDEYESRYSAAFPPQLRARLRDAARGMFAFGYDSYMRHAFPSDELDPLHCCGRGPDRDDPSNLNINDVLGNYSLTLIDALDTLAVMGNSSEFQRAVKLVIDTVSFDKDSTVQVFEATIRVLGSLLSAHIIITDAKQPFGDMTIKDYDNELLHMAHDLAVRLLPAFENTKTGIPYPRVNLKKGVPPNSNNETCTAGAGSLLVEFGILSRLLGDSTFEWVARRAVKALWSLRSNNTGLLGNVVNIQTGHWVGKQSGLGAGSDSFYEYLLKSYILFGEKEDLEMFIDAYQNIQNHLRRGREACNEGEGDPPLYVNVNMFTGQLMNTWIDSLQAFFPGLQVLIGDVEDAICLHAFYYAIWKRYGALPERYNWQLQAPDVPFYPLRPELVESTYLLYQATKNPFYLHVGMDILQSLEKYTKAKCGYATLHHVVEKTKEDRMESFFLSETCKYLYLLFDEDNPVHKSGNKYMFTTEGHIVSVDERFRNSLWQDILPGEEGSTEKVKPNELKAVNFSSNCNRVPDERRYLLPLKSNYMRQIDQMVGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SLS6</accession>
    <name>A0A8C2SLS6_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Heat shock transcription factor 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">HSF4</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the HSF family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SLS6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005001161.1">
        <property type="protein sequence ID" value="ENSCJPP00005000657.1"/>
        <property type="gene ID" value="ENSCJPG00005000736.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158063"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001046">
        <property type="term" value="F:core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22121">
        <property type="entry name" value="F-box_FBXL8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.50:FF:000005">
        <property type="entry name" value="F-box/LRR-repeat protein 3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000027">
        <property type="entry name" value="Heat shock transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010542">
        <property type="entry name" value="Vert_HSTF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF213">
        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06546">
        <property type="entry name" value="Vert_HS_TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00434">
        <property type="entry name" value="HSF_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="F-box" evidence="12">
        <location>
            <begin position="6"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005000657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="609" mass="68345" checksum="218813FF87B60D25" modified="2022-01-19" version="1">MLASAPDLWSCVPEEILIQIFYYLSLRDRYTAFQVCKQWAGAVSSSSVWHFTEISCDSEDEEGMLQSLCQFLSQIKHLKIRFDQSKEVNRRNVTRILDMLAKQNHKLQQLCIACHGENPYFYSGQDILRSIRNMCNMNNQNGTSFHVFDQGRFAKEVLPKYFKHNNMASFVRQLNMYGFRKVVNIEQGGLVKPERDDTEFQHLCFLQGHEHLLEHIKRKVSVVKSEETKMRQEDLSRLLYEVQILRSQQENMECQMQDMKQQNEVLWREVVSLRQNHSQQQKVINKLIQFLFGQLQSSPGSAGIKRKLPLMLDSGLSAPQVSKFSRHLSVDALHDAYFIQSPSTEPSSCLHSPVVAAGPIISDVTEASPSSVINMQSPPDNDREKCLMLIKEEPASPGVKAAAEPDIPLSGCRACPEPPVLPVAMVQSVLEGKGSCGVTPPGTSQHPERRGRRALLDRTDISDSLEGPDWSLEGLQLLLRSQQYGLEPTSLLDVFNPNLPMSECNLAEVEAGLSPMQRLTVDLEKNATELNSKVFNPSISGACPGKDVLLESSQQFLTDRQSVFGNDIISLPESSSLYVPSENIASYLSSVGVQRDIPLNLSSSTDNNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SN37</accession>
    <name>A0A8C2SN37_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2 5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 5"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2SN37"/>
    <dbReference type="Ensembl" id="ENSCJPT00005000423.1">
        <property type="protein sequence ID" value="ENSCJPP00005000215.1"/>
        <property type="gene ID" value="ENSCJPG00005000288.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157074"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044609">
        <property type="entry name" value="FKBP2/11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45779">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45779:SF7">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0697">Rotamase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="7">
        <location>
            <begin position="131"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005000215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="168" mass="18789" checksum="BC8B1FD0C2925206" modified="2022-01-19" version="1">MGSMGSLWGLWGLMGSLWGLWGPYGVYGVLWGLWGLMGSLWGLWGLWGPYGVYGVPMGSYGVLMGSMWSMVSLWGLMGSLWGPYVVYRVPMWRWALLALALAVDPVPEWRQRVQIGVRRRPENCGVRTRRGDLLHMHYTGRLEDGSQFDSSVGRGQPFVFSLGTGQVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SPG0</accession>
    <name>A0A8C2SPG0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">U6 snRNA-associated Sm-like protein LSm6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LSM6</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates. Component of the cytoplasmic LSM1-LSM7 complex, which is thought to be involved in mRNA degradation by activating the decapping step in the 5'-to-3' mRNA decay pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the precatalytic spliceosome (spliceosome B complex). Component of the U4/U6-U5 tri-snRNP complex, a building block of the precatalytic spliceosome (spliceosome B complex). The U4/U6-U5 tri-snRNP complex is composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8 form a heptameric, ring-shaped subcomplex (the LSM2-8 complex) that is part of the U4/U6-U5 tri-snRNP complex and the precatalytic spliceosome. Component of the heptameric LSM1-LSM7 complex, which consists of LSM1, LSM2, LSM3, LSM4, LSM5, LSM6 and LSM7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SPG0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005002985.1">
        <property type="protein sequence ID" value="ENSCJPP00005001775.1"/>
        <property type="gene ID" value="ENSCJPG00005001811.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154978"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120115">
        <property type="term" value="C:Lsm2-8 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071005">
        <property type="term" value="C:U2-type precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01726">
        <property type="entry name" value="LSm6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000010">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016487">
        <property type="entry name" value="Lsm6/sSmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F SNRNP-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021:SF1">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="9" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="8" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Sm" evidence="16">
        <location>
            <begin position="33"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00054795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00065816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005001775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="121" mass="13567" checksum="AD4FA4B555F06609" modified="2022-01-19" version="1">MPAGWDVLLIHISAFTSIPSVPTQIKMSLRKQTPSDFLKQIIGRPVVVKLNSGVDYRGVLACLDGYMNIALEQTEEYVNGQLKNKYGDAFIRGNNGNSSFLCCMYFLQRFFSVPVLFLRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SRB5</accession>
    <name>A0A8C2SRB5_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Colipase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SRB5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005003783.1">
        <property type="protein sequence ID" value="ENSCJPP00005002115.1"/>
        <property type="gene ID" value="ENSCJPG00005002278.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007586">
        <property type="term" value="P:digestion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.80.10">
        <property type="entry name" value="Lipase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001981">
        <property type="entry name" value="Colipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017914">
        <property type="entry name" value="Colipase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017915">
        <property type="entry name" value="Colipase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02740">
        <property type="entry name" value="Colipase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00023">
        <property type="entry name" value="COLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57190">
        <property type="entry name" value="Colipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00121">
        <property type="entry name" value="COLIPASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51342">
        <property type="entry name" value="COLIPASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034356507" description="Colipase C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Colipase C-terminal" evidence="2">
        <location>
            <begin position="57"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005002115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="105" mass="11347" checksum="6044845BB9F015D6" modified="2022-01-19" version="1">MMLPLRLLLVALLVTLALGAPNERGLIFNLVMGEHTSPPCDICFGVSGPKGRCLTEPLSPQSLYGVYYKCPCESGLSCDADWSIVGSITNTDYGICYDKRDSASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SRS1</accession>
    <name>A0A8C2SRS1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-rRNA-processing protein TSR2 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in 20S pre-rRNA processing.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TSR2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SRS1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005003238.1">
        <property type="protein sequence ID" value="ENSCJPP00005001867.1"/>
        <property type="gene ID" value="ENSCJPG00005001934.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000185947"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019398">
        <property type="entry name" value="Pre-rRNA_process_TSR2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21250">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN TSR2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10273">
        <property type="entry name" value="WGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005001867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="159" mass="17396" checksum="64A656D6668693A1" modified="2022-01-19" version="1">MMGAVTWGVFWGSTGPVGSVMGRVMGCAPHAVPAGLQQDEVEQFLAEVMDNEFDTAVEDGSLQEVSRQLLWLWGASCRGDVPAVGRALSSLSLRAPGIRAAVAATQRGGDEKNKKKKKQNRGKRRGFFFFFLGGSKKTVSRLDFFGSFKKYCRNFVVPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SSH4</accession>
    <name>A0A8C2SSH4_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Insulin-induced gene 1 protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the INSIG family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SSH4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005004816.1">
        <property type="protein sequence ID" value="ENSCJPP00005002583.1"/>
        <property type="gene ID" value="ENSCJPG00005002894.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000007463"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032937">
        <property type="term" value="C:SREBP-SCAP-Insig complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032869">
        <property type="term" value="P:cellular response to insulin stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006695">
        <property type="term" value="P:cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032933">
        <property type="term" value="P:SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036316">
        <property type="term" value="P:SREBP-SCAP complex retention in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025929">
        <property type="entry name" value="INSIG_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15301">
        <property type="entry name" value="INSULIN-INDUCED GENE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15301:SF11">
        <property type="entry name" value="INSULIN-INDUCED GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="11" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005002583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="134" mass="14209" checksum="EF7338F5F44C9D1E" modified="2022-01-19" version="1">MPRLESGSWSCSCAARARHAARPGEAALKAGAMRSPSPSAGRAVRDAAGCSATTWRQHLVQRSLVLFVVGAFMALVLNLLQIQRNVTLFPDEVIATLFSSAWWVPPCCGTAAGEHLYRLGGVVLESSSAEKDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2STS0</accession>
    <name>A0A8C2STS0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Translin-associated protein X</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Translin-associated factor X</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">TSNAX</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Acts in combination with TSN as an endonuclease involved in the activation of the RNA-induced silencing complex (RISC). Possible role in spermatogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="17">Ring-shaped heterooctamer of six TSN and two TSNAX subunits. Interacts with GOLGA3, TSNAXIP1, SUN1 and AKAP9. Interacts with the homodimeric form of C1D following gamma-radiation. Interacts with TSN and C1D in a mutually exclusive manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the translin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2STS0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005006461.1">
        <property type="protein sequence ID" value="ENSCJPP00005003682.1"/>
        <property type="gene ID" value="ENSCJPG00005003823.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153568"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902555">
        <property type="term" value="C:endoribonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.190:FF:000002">
        <property type="entry name" value="Translin-associated factor X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.200:FF:000001">
        <property type="entry name" value="Translin-associated factor X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.190">
        <property type="entry name" value="Translin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.200">
        <property type="entry name" value="Translin, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016069">
        <property type="entry name" value="Translin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002848">
        <property type="entry name" value="Translin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016068">
        <property type="entry name" value="Translin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036081">
        <property type="entry name" value="Translin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10741">
        <property type="entry name" value="TRANSLIN AND TRANSLIN ASSOCIATED PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01997">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74784">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="9" id="KW-0221">Differentiation</keyword>
    <keyword evidence="14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="10 20" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0744">Spermatogenesis</keyword>
    <keyword evidence="11" id="KW-0832">Ubl conjugation</keyword>
    <feature type="binding site" evidence="20">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="21">
        <location>
            <position position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00037653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00038594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00041076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00042076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR602848-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR602848-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005003682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="383" mass="43062" checksum="16FCC9FD48A6CC4D" modified="2022-01-19" version="1">FQNRVRGAFHPDFSGLHCLYSTSVYKPQSYEVFLYSLFSGLVSPCLVHTCAVRPSVFCSEIILCLCSVVSGRVALLWQAEGNGGLHSYALFRSTAHTGIRLTGAEAHSCNCSTGSQLLAYTVFCDNHAVKIDSAAFQLELDTRHDKYERLVKLSRDITIESKRTIFLLHRYISAPNGEEVLNESEVKLDAVRRKIKQVAQELIGEDMYQFHRAISPGLQEYIEAVSFQYFIKTRSLISVEEINKQLIFTTEDREETTNTPSSSQDKQPHTWSLKVTPVDYLLGVADLTGELMRLCISSVGNGDIDTPFELSQFLRQIYDGFTFIGNTGPYEVSKKLYTLKQSLAKVENACYTLKVRGSEIPKHMLADVFSTKTELIDQEEGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SUP5</accession>
    <name>A0A8C2SUP5_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Inhibin beta C chain-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">INHBC</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B. Activin A is a homodimer of beta-A. Activin B is a homodimer of beta-B. Activin AB is a dimer of beta-A and beta-B.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimeric or heterodimeric through association with alpha and beta subunits, linked by one or more disulfide bonds. Inhibins are heterodimers of one alpha and one beta subunit. Activins are homo- or heterodimers of beta subunits only.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the TGF-beta family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015742426.1">
        <property type="nucleotide sequence ID" value="XM_015886940.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SUP5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005005980.1">
        <property type="protein sequence ID" value="ENSCJPP00005003354.1"/>
        <property type="gene ID" value="ENSCJPG00005003554.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107325784"/>
    <dbReference type="KEGG" id="cjo:107325784"/>
    <dbReference type="CTD" id="3626"/>
    <dbReference type="GeneTree" id="ENSGT00940000160065"/>
    <dbReference type="OrthoDB" id="6516235at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome LGE22C19W28_E50C23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19406">
        <property type="entry name" value="TGF_beta_INHBC_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.90.10:FF:000005">
        <property type="entry name" value="Inhibin beta A chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001318">
        <property type="entry name" value="Inhibin_betaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001839">
        <property type="entry name" value="TGF-b_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015615">
        <property type="entry name" value="TGF-beta-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017948">
        <property type="entry name" value="TGFb_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848:SF130">
        <property type="entry name" value="INHIBIN BETA C CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848">
        <property type="entry name" value="TGF-BETA FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00019">
        <property type="entry name" value="TGF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00672">
        <property type="entry name" value="INHIBINBC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00204">
        <property type="entry name" value="TGFB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00250">
        <property type="entry name" value="TGF_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51362">
        <property type="entry name" value="TGF_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 12" id="KW-0339">Growth factor</keyword>
    <keyword evidence="5" id="KW-0372">Hormone</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034795012" evidence="13">
        <location>
            <begin position="18"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="TGF-beta family profile" evidence="14">
        <location>
            <begin position="225"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00026046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00065862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005003354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="343" mass="37630" checksum="C03CBCED635B9AEA" modified="2022-01-19" version="1">MAALLTFLLLILLWTHAAPRCPGCGLTALPPPAQRRLLLAMAQRSILARLHLHEPPRPLQPPNRAALLSALYRVRPQLVAPQRPPGAAEQNYEVLSFAEAGPSTPLSSLLLFRFSPELRVNSKVLQAHLHLFHPPPPGPGSSQPVSIRLLNGDSKQNISVDTLDVNGDGWAMLDVSDELRSALNRGKEQLIIELSTTRPPGPPPLISDPYRPFVAIKARRGASNRRRRRGIDCGGSTRMCCRKDFYVDFKEIGWDGWIIQPEGYHMNYCAGLCPPHVAAVPGVAASFHTAVLNLIKANDAEAEADSCCVPTQRRPLSLLYYDRDSNIVKTDIPDMIVDACGCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SUY1</accession>
    <name>A0A8C2SUY1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Rho GTPase-activating protein 29</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Rho-type GTPase-activating protein 29</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ARHGAP29</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SUY1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005007102.1">
        <property type="protein sequence ID" value="ENSCJPP00005004193.1"/>
        <property type="gene ID" value="ENSCJPG00005004217.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183110"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030165">
        <property type="term" value="F:PDZ domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20816">
        <property type="entry name" value="C1_GMIP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04409">
        <property type="entry name" value="RhoGAP_PARG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000016">
        <property type="entry name" value="Rho GTPase activating protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054713">
        <property type="entry name" value="GMIP/FCHO2-like_FCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057028">
        <property type="entry name" value="RHG29_45_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051025">
        <property type="entry name" value="RhoGAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15228:SF7">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15228">
        <property type="entry name" value="SPERMATHECAL PHYSIOLOGY VARIANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22699">
        <property type="entry name" value="GMIP-like_FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24235">
        <property type="entry name" value="RHG29_45_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="F-BAR" evidence="13">
        <location>
            <begin position="194"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="11">
        <location>
            <begin position="584"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="12">
        <location>
            <begin position="642"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="508"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="363"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="516"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00042921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005004193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="926" mass="104442" checksum="25F2ABA183C469C6" modified="2022-01-19" version="1">YIYIYEKNTKQSRTLIMHQLSGVTTKSSSLSSISSNSDCYDNPVVDPEYIMQLVNDVRKFADVLLYLKEAICSEVVHERLGELLRVLKAVINKHQTLNSVDILSAAGTVIAKVKAVNFKEVNEENKRELFSEVFSSIETLAFTFGNVISDFLMGDVDNGSSLGLPVSRRSRCVVMSKIHSFAFDALFSGHLRAEEVDSMLLRNGSGIESALLYAKAWSKYTKDVVAWVEKKLSLEVECAKNLAKMAETAKAVVGPQDYMPFQSIFLNAFQNDIENNQLWQQTAAALQSNKFVQPLLGRKNELDKQRKEIKELWQREQKKMVELEASLRKAKLLYMQRQDEYEKAKSSTARAEEEHLSSSGSFVKDISKQLEKKRRLEEEALQKAEEANEYYKASMAEVEEKRSDLESFKSDVLTQLRELIYQCDLTLKAVTVNLFQLQHAQVVSLPVNCQSLCESAKLYDPGQQYSEFVKSLPKEGILKKIVVLHICNWILFLKVMRGPPPFRSWSVGNQSGGMCSDSESAGGSSESRSMDSPSASPGDFKRRLPRTPSTGTMSSADDLDEREPPSPSDCGPFRNTNMSKAAQTHKLRKLRALSKCRECDSLVVFGAECEECSLACHKKCLETLAIQCGHKKLHGRLHLFGVEFAQAAKNIPDGIPFIIKKCTSEIESRALNVKGIYRVNGAKSRVEKLCQAFENGSDLVELSELYAHDISNVLKLYLRQLPEPLILFRLYNEFIGLAKESQSISEELDAKQASPKSKKRQSICIELNRIIIKIKDLLKQLPVPNYNTLQYLIGHLHRVTEQSDENKMSASNLGIIFGPTLIRPRQTDATVSLSSLADYPYQARVVELLITYYEKIFDVSSQPFLSTSQTEENAVTVRIAFSAEEREPQQQRKSFVAVKEVSHFSCTFLGRNVFSLVLIYFCSDFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SV30</accession>
    <name>A0A8C2SV30_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MLX interacting protein like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">MLXIPL</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SV30"/>
    <dbReference type="Ensembl" id="ENSCJPT00005007117.1">
        <property type="protein sequence ID" value="ENSCJPP00005004208.1"/>
        <property type="gene ID" value="ENSCJPG00005004057.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159210"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061629">
        <property type="term" value="F:RNA polymerase II-specific DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010255">
        <property type="term" value="P:glucose mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090324">
        <property type="term" value="P:negative regulation of oxidative phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901797">
        <property type="term" value="P:negative regulation of signal transduction by p53 class mediator"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045723">
        <property type="term" value="P:positive regulation of fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045821">
        <property type="term" value="P:positive regulation of glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035774">
        <property type="term" value="P:positive regulation of insulin secretion involved in cellular response to glucose stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000432">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by glucose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd19689">
        <property type="entry name" value="bHLHzip_MLXIPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21771">
        <property type="entry name" value="NES2-NLS_ChREBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000028">
        <property type="entry name" value="MLX interacting protein like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052207">
        <property type="entry name" value="Max-like/E-box_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741:SF14">
        <property type="entry name" value="CARBOHYDRATE-RESPONSIVE ELEMENT-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="9">
        <location>
            <begin position="691"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="436"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="524"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="649"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="826"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="742"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="682"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005004208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="852" mass="92811" checksum="ADF5EAE6D9B4FEBC" modified="2022-01-19" version="1">MAQAQLGLAAPFTQPPAGPGPDSDFDSDSEDAAVGGAGPGTARQSPSQVIHSGHFMVSSPHHDAPPHRRHRRAEPSAADPRSIDPTLTWLFECMSLEYSGKLVSPKWKNFKGQRLLCRDKIRLNNAIWRAWYIQYVEQRKNPVCGFITPLEGSEADEHRKPEAVVLEGNYWKRRIEVVMREYHKWRTYYKKRLRKSSREGELCSPKQDEDAWRPTEKWCNQLFCNVVPMLLGDEEEEPGGRQHFDLDTFLSDISDTLFTMTQIPSAHQELPEDAYIGNADMIQPDLAPLQPSLDDTMEISDIFVGHRPLPAQMPLGYQEPPCFEPLYGNGGTVPAGPDAPLPPSPLLQVSGTLAHDPRLPVPEPPLLTQPCAPQPGDATQLSLHGAFFGPEQPPLAPEPLTAVPGCLSPQLKPKPLLQYGFPSKCLGTEPLSLPYTAPSQAPGTPLLGSQPPFSPASVPHSKFPFPPSPSPSLLTHPASPLPVPCFAQHTPGLGYAMDVVPVGYPSPAAPQHLHPAVPPAPRFATPKGPSLGERPKVKATKAKRPPDPPVPPHLTVPNVCLTQLLATAKQEPALDAPHMHGPALMPASPASPQSNVPDVPDVFLPRVAQLSSVLSPGSSPSQEVPVLQAGAAPGSLRVPKVERLSPTLVCGSDWPKPSQVSPGAAPPPSATVSLHHPSSRRGRPDSSKMENRRITHISAEQKRRFNIKLGFDTLHSLVSTLSAQPSIKVSKATTLQKTAEYICKLQQERAALQDEAQRLREQIEELNSSINLCQEQLPATGVPITRQRFDQMRGMFDDYVRSSTLHNWKFWIVSFGSALDAQCPFHHTPGPPSPPSCGTRSDSLGSRLKCPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SWU1</accession>
    <name>A0A8C2SWU1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">DHX58</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. RLR subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2SWU1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005008229.1">
        <property type="protein sequence ID" value="ENSCJPP00005005003.1"/>
        <property type="gene ID" value="ENSCJPG00005004851.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153173"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140374">
        <property type="term" value="P:antiviral innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002753">
        <property type="term" value="P:cytoplasmic pattern recognition receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045824">
        <property type="term" value="P:negative regulation of innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0039534">
        <property type="term" value="P:negative regulation of MDA-5 signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0039536">
        <property type="term" value="P:negative regulation of RIG-I signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032480">
        <property type="term" value="P:negative regulation of type I interferon production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900245">
        <property type="term" value="P:positive regulation of MDA-5 signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:positive regulation of RIG-I signaling pathway"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:positive regulation of type I interferon production"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd15806">
        <property type="entry name" value="LGP2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12090">
        <property type="entry name" value="MDA5_ID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18802">
        <property type="entry name" value="SF2_C_dicer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1320.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.30">
        <property type="entry name" value="RIG-I-like receptor, C-terminal regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
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    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041204">
        <property type="entry name" value="RIG-I-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038557">
        <property type="entry name" value="RLR_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021673">
        <property type="entry name" value="RLR_CTR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051363">
        <property type="entry name" value="RLR_Helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14074:SF7">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14074">
        <property type="entry name" value="HELICASE WITH DEATH DOMAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18119">
        <property type="entry name" value="RIG-I_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11648">
        <property type="entry name" value="RIG-I_C-RD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51789">
        <property type="entry name" value="RLR_CTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0391">Immunity</keyword>
    <keyword evidence="5" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="372"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="RLR CTR" evidence="18">
        <location>
            <begin position="557"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
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            <dbReference type="ARBA" id="ARBA00049390"/>
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    </evidence>
    <evidence type="ECO:0000259" key="16">
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005005003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="691" mass="78206" checksum="A62D729EE0731F04" modified="2022-01-19" version="1">MGAHQVHLVQQHLEKEFHVLRDAFKVTAVSGDSSYRCFFGQMAKGSDVIICTAQILHNALLSGEEDEHVELSGGCGTPRPGWGRPRDERLIALPCFARTDFSLLVIDECHHTHKEAVYNKIMLSYLQKKLSGQRDLPQILGLTASPGTGGETSFEGAVEHILQVGAPELLGLHMGGVLASCSALHGTGLLGLRAGFGALPFQICANLDTEVITSAQEHAQHLQSHVPQPRKQYDLCQERAQDPFGQRLKKIMAQIQEHMDVPGLPLLKDFGTQVYEQRIVELENKAAESFCRKTRVCALHLRKYNDALLINDTVRMMDAFQSLQQFYADERDTKDPTERFLATTFGENRATLLALAGDQRYENPRLSKLEEILQEHFQPLVSSRGIVFTRTRQSAHSLLSWLQDTAGLCGRHIRAAVLTGTGYSNQAKGMTQNEQQDVITQFRSGEINLLFSTSVAEEGLDIPECNIVVRYGLMTNEIAMVQARGRARAQSSVYSVLAKANSREVSREQLNENLVELMERAISTVQAMPEREYRLKIQELQRNAVLSWQVKEARNNERRQLHDPDDVYFHCVNCNVAVCRGSDIRTVEAIHHVNINPNFRFYYTVSSGKIHFERTFRDWEPGCRIVCSECRQEWGIEMIYKSVTLPILSIKNFVVVTPDEKKKYKKWSRVTFPIEEFSYLEYCSNSQDESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SYX7</accession>
    <name>A0A8C2SYX7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">SIK2</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="RefSeq" id="XP_015739285.1">
        <property type="nucleotide sequence ID" value="XM_015883799.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SYX7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005009138.1">
        <property type="protein sequence ID" value="ENSCJPP00005005671.1"/>
        <property type="gene ID" value="ENSCJPG00005005385.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107324108"/>
    <dbReference type="KEGG" id="cjo:107324108"/>
    <dbReference type="CTD" id="23235"/>
    <dbReference type="GeneTree" id="ENSGT00940000156445"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050321">
        <property type="term" value="F:tau-protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14071">
        <property type="entry name" value="STKc_SIK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14409">
        <property type="entry name" value="UBA_SIK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000154">
        <property type="entry name" value="Serine/threonine-protein kinase SIK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034672">
        <property type="entry name" value="SIK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057380">
        <property type="entry name" value="UBA_SIK1/2/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF38">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23312">
        <property type="entry name" value="UBA_SIK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="25"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="18">
        <location>
            <begin position="300"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="564"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="645"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="745"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="799"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="645"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="753"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="808"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005005671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="911" mass="102339" checksum="30B9077C5EEBFF1B" modified="2022-01-19" version="1">MVMAEPRRPPPLLPRGPGPVRVGFYDIEGTLGKGNFAVVKLARHRITRSEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEFAKNGEIFDYLASHGRLSESEARRKFWQILSAVEYCHSRKVVHRDLKAENLLLDNNMNIKIADFGFGNFYKSGEPLTTWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPAQRSIIYAPGQENQPSIGEYNEQVLRLMHSLGIDQQKTTESLQNKSYNHFAAIYYLLVERLKSHRSSFPVEQRFDARQRRPSTIAEQTVAKAQAVVPSVNLCSENTRLLRSPGLPPTSGAEAFSFPPSNCQTDTTFMEEERVNTPKVNGCLLDPVPPMVMRKGCQSLPSTMMETSIDEGIETEGEAEDDPAQSFAALQAARSGKRRHTLAEVTDQLAAVPGKGKVYSLDENSSLGSSIESEYDMGSVQRNVGLLGDAPPLKDVVPLASPFLGLRPTNPAMQALASQKRETHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQMRSEEEPLLPSAAPQLQDLATNPAQEETPQQQEAAGTFPSGAHTPVLSRRLSLETQYLQHRLQKPTLLSKAPNTCQLYCKELPRSLEQQLQEHRLHQKRLFLQKQSQLQAYFNQMQIAESSYPRSSQMPLSCQEEQQPSAQQQSTQFSLQQALSPVMEPSSEQMQYNLFLSHYQKVQLEPPPPSPITSSSQLSSPIQVQQPAQSLQYSYQTCELPVVTSSEPDYPDQCQYSMDPAQQSGVALPDSQGSLTAHEPQSNYDALALSELPGLFDCEMMETVDPQHSGYVLVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SZ23</accession>
    <name>A0A8C2SZ23_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ubiquitin conjugating enzyme E2 N</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">UBE2N</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015713656.1">
        <property type="nucleotide sequence ID" value="XM_015858170.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SZ23"/>
    <dbReference type="SMR" id="A0A8C2SZ23"/>
    <dbReference type="Ensembl" id="ENSCJPT00005008382.1">
        <property type="protein sequence ID" value="ENSCJPP00005005113.1"/>
        <property type="gene ID" value="ENSCJPG00005004949.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107311567"/>
    <dbReference type="KEGG" id="cjo:107311567"/>
    <dbReference type="CTD" id="7334"/>
    <dbReference type="GeneTree" id="ENSGT00540000070023"/>
    <dbReference type="OrthoDB" id="7851174at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031372">
        <property type="term" value="C:UBC13-MMS2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097027">
        <property type="term" value="F:ubiquitin-protein transferase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140374">
        <property type="term" value="P:antiviral innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031669">
        <property type="term" value="P:cellular response to nutrient levels"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006301">
        <property type="term" value="P:DNA damage tolerance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000729">
        <property type="term" value="P:DNA double-strand break processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043123">
        <property type="term" value="P:positive regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000781">
        <property type="term" value="P:positive regulation of double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902523">
        <property type="term" value="P:positive regulation of protein K63-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070534">
        <property type="term" value="P:protein K63-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050852">
        <property type="term" value="P:T cell receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd23813">
        <property type="entry name" value="UBCc_UBE2N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000015">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="5">
        <location>
            <begin position="3"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005005113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="152" mass="17138" checksum="FACD84D883D77407" modified="2022-01-19" version="1">MAGLPRRIIKETQRLLAEPVPGIKAEPDESNARYFHVVIAGPQDSPFEGGTFKLELFLPEEYPMAAPKVRFMTKIYHPNVDKLGRICLDILKDKWSPALQIRTVLLSIQALLSAPNPDDPLANDVAEQWKTNEAQAIETARAWTRLYAMNNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SZ34</accession>
    <name>A0A8C2SZ34_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Centrosomal protein 83</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">CEP83</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SZ34"/>
    <dbReference type="Ensembl" id="ENSCJPT00005008400.1">
        <property type="protein sequence ID" value="ENSCJPP00005005125.1"/>
        <property type="gene ID" value="ENSCJPG00005004959.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154003"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:ciliary transition fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="C:Golgi apparatus"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:cilium assembly"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:establishment of centrosome localization"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:protein localization to centrosome"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052116">
        <property type="entry name" value="Centro_Cilium_Assembly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23170:SF2">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 83 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23170">
        <property type="entry name" value="NY-REN-58 ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034122070" evidence="6">
        <location>
            <begin position="23"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="59"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="151"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="461"/>
            <end position="649"/>
        </location>
    </feature>
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        <location>
            <begin position="682"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
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    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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            <dbReference type="Ensembl" id="ENSCJPP00005005125.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="742" mass="87294" checksum="A9A58D1516ADAFE5" modified="2022-01-19" version="1">MLVYVCYKVIFHFVLSIAIVNGHQKMDPLGSLLPPVAGNSDVANSEELQKLLIDEKRRCEHHKANYQTIKAEHMRLQEEYTKSQDELKQLLVEKQTVHDKFQLLLAEYREELLGKTQELEKLKMQVLTPQKLELIKAQIQQELESPMAERYRKLENEMEKYRTEYNKLRYEHTFLKSEFEHQREEHEHALEEEKIKHEAEIARLEKDKEELHNRLVSIDPTRDSKRVEILSREKAQLHQKLKGLEAEVAELRAERDNCGVQAENVQRVQVRQLAELQSLTRSLEAEKKSAEQHVGRIEEELKVCREQNFLLTSKLHKSEQEVNSLAAKVEELKQSHKLEVTNVKLEAARTKNEVERERNKIQSEMDGLLSDKEVLKEAVERHKVLLVEKDQELVRKVQAAKEEVFGKIAALQDEKLDLESRLAHLEKVKLEQDAWRQTEKDQYEEKLRVVQLAEESSRRELECLRLKIQQQAIQTEELEEKKRERDELKQQIQDMQLQVASLSQSENDLLEYNQKLKETVERLRQECQNARTQAEKAQLETEKNLEYRRIEWLEEKHLLTQRISEKEEKYNEVKNKLCRAAVAQKKRKTLNDNKQRRMQEKLQLLEAKIEELEKENQVLNRQNVSYEEYARLQKRLKDLQRRHNEFRSLILNPGIPSLNPVSVTSASVPPPGPDLSFLLLQEEQHQRELSLLRKRLEDLETTQRKQLQELGPAGERLTVGARRELASSRGAEGAAVQSEDST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T042</accession>
    <name>A0A8C2T042_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Sulfotransferase</fullName>
            <ecNumber evidence="15">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">HS3ST6</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endomembrane system</location>
            <topology evidence="11">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="15"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2T042"/>
    <dbReference type="Ensembl" id="ENSCJPT00005009449.1">
        <property type="protein sequence ID" value="ENSCJPP00005005928.1"/>
        <property type="gene ID" value="ENSCJPG00005005605.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154768"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008467">
        <property type="term" value="F:[heparan sulfate]-glucosamine 3-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015012">
        <property type="term" value="P:heparan sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="Sulfotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037359">
        <property type="entry name" value="NST/OST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10605:SF62">
        <property type="entry name" value="HEPARAN SULFATE GLUCOSAMINE 3-O-SULFOTRANSFERASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10605">
        <property type="entry name" value="HEPARAN SULFATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="17">
        <location>
            <begin position="184"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="active site" description="For sulfotransferase activity" evidence="12">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="193"/>
            <end position="197"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="399"/>
            <end position="403"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="382"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00060399"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR637359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR637359-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR637359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005005928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="436" mass="47247" checksum="90C00E216FFD6E90" modified="2022-01-19" version="1">MNQRSPQGSPRPRGLSRAPGCRGAAPRVSSVPGPVRPTRARPPPPAGGSGGGAQGGPGRAGPGRGGAGRGRAGGAERSGARRRGRCWGRAGCAARRGGGGGLRGERPPMGCSGRLLGPVGGRRASLLLTMILFFTYFFYCLPGPCEPLPPALLLPPPAALPDGAAPTAAGDASPALGGGSRRFPQAIIVGVKKGGTRALLEFLRVHPGVRAVGAEPHFFDRCYEKGLRWYRSLMPRTLEGQITMEKTPSYFVTKEAPRRIYNMSRDTKLIVVVRNPVTRAISDYTQTLSKNPTIPSFQDLAFKNVSTGLIDTSWSAVRIGIYAKHLDNWLQYFPLSKFLFVSGERLVSDPAGEMGRVQDFLGLKRVVTDKHFYFNQTKGFPCLKKPEGSSKPRCLGKSKGRPHPKIEGQVVQRLQEFYRPFNMKFYQMTGQDFGWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T0V5</accession>
    <name>A0A8C2T0V5_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Leucine rich repeats and IQ motif containing 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LRRIQ1</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015713084.1">
        <property type="nucleotide sequence ID" value="XM_015857598.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005008075.1">
        <property type="protein sequence ID" value="ENSCJPP00005004915.1"/>
        <property type="gene ID" value="ENSCJPG00005004764.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107311236"/>
    <dbReference type="CTD" id="84125"/>
    <dbReference type="GeneTree" id="ENSGT00940000163898"/>
    <dbReference type="OrthoDB" id="266138at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001142">
        <property type="entry name" value="Leucine-rich repeats and IQ motif containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050836">
        <property type="entry name" value="SDS22/Internalin_LRR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652:SF7">
        <property type="entry name" value="LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652">
        <property type="entry name" value="LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="530"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1254"/>
            <end position="1310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1474"/>
            <end position="1537"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="308"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1481"/>
            <end position="1491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1498"/>
            <end position="1516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1526"/>
            <end position="1537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005004915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1537" mass="177655" checksum="B26EC4421717F179" modified="2022-01-19" version="1">MESRVTEDTEGIEKEIESELSRISVSSFEADDPDTDVSEESVSDTESISDDLPDSVLSYLNFIKSRNQDAEKVILQDSEDEETTSSIHEVIPCYASDKLAELASESNEDSEQFKKRVLFEIETADLKVPTTPSYNNQSCSEVVTDDFFLTADVEMNISLTYHEVEEKCRQKFEQWEKTQSEIEDDKRKKWKAEREAQEKQNEEEHARRVQHLEKFEAERMELELLHKEQQTLMEDELQKKKKAWRDKMIQHEEIITKLQLQMEQEKRAFEEQKANESKHLMEQRNTAAVKIQSRFRAYLVHKKYAPILKQWKDEIKKKKKIQEEIEREMKVKEEKMRRRMEERMQNKKEEKKRQEELERQKYLEQAGRRKEYEEKKAILRLEREKQLQIREEQKKLRVKMAKAIITENGENNRENIEEKKLAENVNVIRDEEKELNEHFEELKEEQAERMGETNSGMISMERKLTPALTLLTSEKEDSSQVNNENICINVVKYVEENYLQTKEDNKEASGIHTLKDESVDFGGNYVVESTSNDTCSSQSNVQSNATNTDDQDQFSQSETIKKTGFLMEDANEKDIKSWDTVQEVSKCSSRLVLPSDIEKKRTNWMSKCKSWSKIYEENQRKIPNSKKRSRKTSFSKMPPLSRQKIIDSGSWSTLQQITTLTLEDLPACSLSTLSECLNLQVLTLRRCGLVALEGLSSCKDLKYINVEENNIQVIDCENLENLCILILNNNHLSSVCGLDGCINLQSLKLSYNRITRIGGLESLKNLQQLTVDHNQLISTKGLCEVPTLIHLDCSFNHLTQVEGIENCGLLQILKLQGNNLQELPKLENHVLLRELYLDDNSISAVRMLSLYWMPLLQILLLSQNSLSELVPLNSFVSLEKLDIKNNCLSDLKSVISCLNGCSNLRELSLSGNPLLQERNWRPSLCKVLPRLQFLDGENLHYNTLPTAEGIKASESTAFLEFCKVQIEENVLLKKKVVEEGIVSSIDAVQRQCWYFNQLMKLSIDHRCAHEYGELSTTDRGRPEALQNHLKQASTGCVQENNLFIMGVTENKQVLLDPSERWITDGHFQATFINSSISVHQKENKEDHRMKQKSTESCINYNGESNGNKNISAQLTLQHSVIESNMGRGFENNTERSHLAASVIQSHWRKYRTRRKTDCAKTRNCHFGEASRQKHEAATVIQASWKGFLLRRKLASVLAAVKSDEVDDNYEEINVDDFISHEAAIGNEWLTPDSTHFLSKTLLISNQLHWTKYARPSDSSEHSGDLQLSPQAPWQRIDRPNSYSTENTHYHRSSEKGTMSQNSDIKEKKKFSIRSDKEEKISEEWGFKDISTAQLMLKRAHKMKPRKYSNKNVDPAVRLALFKKNENKHLRVKPAKIQSVNAGYFEGKKEEFYHLGTSLDEKLQRRKDFTYQWLHTQHSDYETASSENMRGCCFFPELNHGIYNNGQIQLVASPVSREDTELDLVSLASGSALTVNREKNKQPHRQSARSSKKNISTPERSHLGPSCRERISFRDHPLQFSGGWGTGKKRQKHYEKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T116</accession>
    <name>A0A8C2T116_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Netrin-G2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Laminet-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">NTNG2</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Interacts with LRRC4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
            <orientation evidence="1">Extracellular side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015734635.1">
        <property type="nucleotide sequence ID" value="XM_015879149.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T116"/>
    <dbReference type="Ensembl" id="ENSCJPT00005010309.1">
        <property type="protein sequence ID" value="ENSCJPP00005006548.1"/>
        <property type="gene ID" value="ENSCJPG00005006108.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107321806"/>
    <dbReference type="KEGG" id="cjo:107321806"/>
    <dbReference type="CTD" id="84628"/>
    <dbReference type="GeneTree" id="ENSGT00940000153601"/>
    <dbReference type="OrthoDB" id="9981301at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048787">
        <property type="term" value="C:presynaptic active zone membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098685">
        <property type="term" value="C:Schaffer collateral - CA1 synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007409">
        <property type="term" value="P:axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050804">
        <property type="term" value="P:modulation of chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098698">
        <property type="term" value="P:postsynaptic specialization assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001222">
        <property type="term" value="P:regulation of neuron migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0150011">
        <property type="term" value="P:regulation of neuron projection arborization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010975">
        <property type="term" value="P:regulation of neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905606">
        <property type="term" value="P:regulation of presynapse assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099560">
        <property type="term" value="P:synaptic membrane adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009888">
        <property type="term" value="P:tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000112">
        <property type="entry name" value="Netrin G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000005">
        <property type="entry name" value="Netrin G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000180">
        <property type="entry name" value="Netrin G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000439">
        <property type="entry name" value="Netrin G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:001530">
        <property type="entry name" value="Netrin-G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050440">
        <property type="entry name" value="Laminin/Netrin_ECM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008211">
        <property type="entry name" value="Laminin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056863">
        <property type="entry name" value="LMN_ATRN_NET-like_EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574:SF27">
        <property type="entry name" value="NETRIN-G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574">
        <property type="entry name" value="NETRIN/LAMININ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24973">
        <property type="entry name" value="EGF_LMN_ATRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00055">
        <property type="entry name" value="Laminin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00136">
        <property type="entry name" value="LamNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="Sialidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50027">
        <property type="entry name" value="EGF_LAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51117">
        <property type="entry name" value="LAMININ_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-0221">Differentiation</keyword>
    <keyword evidence="10 18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="18" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="13 19" id="KW-0424">Laminin EGF-like domain</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 20" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034435338" description="Netrin-G2" evidence="20">
        <location>
            <begin position="18"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin N-terminal" evidence="23">
        <location>
            <begin position="35"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="22">
        <location>
            <begin position="410"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="21">
        <location>
            <begin position="453"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="410"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="430"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="478"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00055052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00065506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00068906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00079146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="527" mass="59706" checksum="3CE933E9BCE51DB8" modified="2022-01-19" version="1">MLYLLAFLLHCLPLAMGQYDICKSWVTTDDGPSWEFYACQPKAMRMKDYVTVRVDPAGITCGDPPERFCTHENPYLCSDECDASNPDLAHPPKLMFDSEDEGLATYWQSVTWRRYPEPLLANITLSWNKSIELTDDIVITFEYGRPTIMMLEKSLDNGRTWHPYQYYADDCMEAFSMPARRVRDLSTTSANRVLCTEEYSRWAGSKKEKTVRFEVRDRFAIFAGPDLKNMDNLYTRLESAKGLKDFFTVTDLRMRLLRPALGGTYVQRENLYKYFYAVSNIEVTGRCKCNLHANLCTFKEGSLQCECEHNTTGQDCGKCKKNFRSRSWRAGSYLPLPNGSPNACAAAGSAFGNCECYGHSNRCSYIDFLNVVTCVSCKHNTRGQHCQHCRLGFYRNSSAELDDENVCIECNCNQIGSLHDRCNETGYCECKEGATGPKCDDCLPNYYWRQGCFPNVCDDELLLCQNGGTCYQNQRCICPVGFKGVLCQQSRCEADRKDCDGASSTRAAISTVVFGVLGLQLRGWANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T1J8</accession>
    <name>A0A8C2T1J8_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein uS12m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">28S ribosomal protein S12, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">MRPS12</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015706355.1">
        <property type="nucleotide sequence ID" value="XM_015850869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T1J8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005010953.1">
        <property type="protein sequence ID" value="ENSCJPP00005007049.1"/>
        <property type="gene ID" value="ENSCJPG00005006504.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107307366"/>
    <dbReference type="KEGG" id="cjo:107307366"/>
    <dbReference type="CTD" id="6183"/>
    <dbReference type="GeneTree" id="ENSGT00550000075103"/>
    <dbReference type="OrthoDB" id="361013at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03368">
        <property type="entry name" value="Ribosomal_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000115">
        <property type="entry name" value="28S ribosomal protein S12, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_uS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005679">
        <property type="entry name" value="Ribosomal_uS12_bac"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00981">
        <property type="entry name" value="rpsL_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002133">
        <property type="entry name" value="Ribosomal_S12/S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01034">
        <property type="entry name" value="RIBOSOMALS12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00083933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005007049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="135" mass="14822" checksum="591586244798BFAD" modified="2022-01-19" version="1">MSLRAVLRSAALLPYSALGMQPTAAMATLNQMHRQGRPKHPPPKPGATFGRPQLKGVVIKNLIRKPKKPNSANRKCVRVRLSNGKEVVCFVPGEGHNLQEHHVVLVQGGRTQDLPGVKLTVVRGKYDCAHVQKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T2B4</accession>
    <name>A0A8C2T2B4_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A</fullName>
            <ecNumber evidence="6">2.4.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">STT3A</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a di-trans,poly-cis-dolichyl diphosphooligosaccharide + L-asparaginyl-[protein] = N(4)-(oligosaccharide-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein] + a di-trans,poly-cis-dolichyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22980"/>
            <dbReference type="Rhea" id="RHEA-COMP:12804"/>
            <dbReference type="Rhea" id="RHEA-COMP:12805"/>
            <dbReference type="Rhea" id="RHEA-COMP:19506"/>
            <dbReference type="Rhea" id="RHEA-COMP:19509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:50347"/>
            <dbReference type="ChEBI" id="CHEBI:57497"/>
            <dbReference type="ChEBI" id="CHEBI:57570"/>
            <dbReference type="ChEBI" id="CHEBI:132529"/>
            <dbReference type="EC" id="2.4.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="19">Component of the oligosaccharyltransferase (OST) complex. There are 2 OST complexes, OST-A and OST-B, which contain STT3A or STT3B as catalytic subunit, respectively. OST-A and OST-B contain common core subunits RPN1, RPN2, OST48, OST4, DAD1 and TMEM258, and OST-A contains DC2/OSTC and KRTCAP2/KCP2 specific accessory subunits. OST-A complex assembly occurs through the formation of 3 subcomplexes. Subcomplex 1 contains RPN1 and TMEM258, subcomplex 2 contains the OST-A-specific subunits STT3A, DC2/OSTC, and KCP2 as well as the core subunit OST4, and subcomplex 3 contains RPN2, DAD1, and OST48. The OST-A complex can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the STT3 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.18" evidence="6"/>
    <dbReference type="RefSeq" id="XP_015739536.1">
        <property type="nucleotide sequence ID" value="XM_015884050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T2B4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005009596.1">
        <property type="protein sequence ID" value="ENSCJPP00005006045.1"/>
        <property type="gene ID" value="ENSCJPG00005005693.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107324223"/>
    <dbReference type="KEGG" id="cjo:107324223"/>
    <dbReference type="CTD" id="3703"/>
    <dbReference type="GeneTree" id="ENSGT00940000156655"/>
    <dbReference type="OrthoDB" id="10261066at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160226">
        <property type="term" value="C:oligosaccharyltransferase complex A"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004579">
        <property type="term" value="F:dolichyl-diphosphooligosaccharide-protein glycotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043687">
        <property type="term" value="P:post-translational protein modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12610:FF:000002">
        <property type="entry name" value="dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054479">
        <property type="entry name" value="AglB-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003674">
        <property type="entry name" value="Oligo_trans_STT3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048307">
        <property type="entry name" value="STT3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872:SF43">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT STT3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22627">
        <property type="entry name" value="AglB_core-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02516">
        <property type="entry name" value="STT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16" id="KW-0464">Manganese</keyword>
    <keyword evidence="14 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="170"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="192"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="451"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Oligosaccharyl transferase STT3 N-terminal" evidence="21">
        <location>
            <begin position="17"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="AglB-like core" evidence="22">
        <location>
            <begin position="512"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00040922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00062993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF02516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF22627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="705" mass="80594" checksum="0073A01A83332C68" modified="2022-01-19" version="1">MTKLGFLRLSYEKQDTLLKLLILSMAAVLSFSTRLFSVLRFESVIHEFDPYFNYRTTRFLAEEGFYKFHNWFDDRAWYPLGRIIGGTIYPGLMITSAAIYHVLHFFHITIDIRNVCVFLAPLFSSFTTIVTYHLTKELKDAGAGLLAAAMIAVVPGYISRSVAGSYDNEGIAIFCMLLTYYMWIKAVKTGSIYWAAMCALAYFYMVSSWGGYVFLINLIPLHVLVLMLTGRFSHRIYVAYCTVYCLGTILSMQISFVGFQPVLSSEHMAALGVFGLCQIHAFVDYLRSKLNPQQFEVLFRSVISLVGFVLLTVGAVLMLTGKISPWTGRFYSLLDPSYAKNNIPIIASVSEHQPTTWSSYYFDLQLLVFMFPVGLYYCFSNLSDARIFIIMYGVTSMYFSAVMVRLMLVLAPVMCILSGIGVSQVLSTYMKNLDISRPDKKSKKQQDSTYPIKNEVASGMILVMAFFLITYTFHSTWVTSEAYSSPSIVLSARGGDGSRIIFDDFREAYYWLRHNTPEDAKVMSWWDYGYQITAMANRTILVDNNTWNNTHISRVGQAMASTEEKAYEIMRELDVSYVLVIFGGLTGYSSDDINKFLWMVRIGGSTDTGRHIKEHDYYTPTGEFRVDREGSPVLLNCLMYKMCYYRFGQVYTEAKRPPGYDRVRNAEIGNKDFELDVLEEAYTTEHWLVRIYKVKDLDNRGLSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T2N5</accession>
    <name>A0A8C2T2N5_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TBC1 domain family member 31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">TBC1D31</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Molecular adapter which is involved in cilium biogenesis. Part of a functional complex including OFD1 a centriolar protein involved in cilium assembly. Could regulate the cAMP-dependent phosphorylation of OFD1, and its subsequent ubiquitination by PJA2 which ultimately leads to its proteasomal degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
            <location evidence="2">Centriolar satellite</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015711680.1">
        <property type="nucleotide sequence ID" value="XM_015856194.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T2N5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005009607.1">
        <property type="protein sequence ID" value="ENSCJPP00005006054.1"/>
        <property type="gene ID" value="ENSCJPG00005005701.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107310496"/>
    <dbReference type="KEGG" id="cjo:107310496"/>
    <dbReference type="CTD" id="93594"/>
    <dbReference type="GeneTree" id="ENSGT00940000153859"/>
    <dbReference type="OrthoDB" id="5578278at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000226">
        <property type="entry name" value="TBC1 domain family member 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000185">
        <property type="entry name" value="TBC1 domain family member 31 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000022">
        <property type="entry name" value="TBC1 domain family, member 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051570">
        <property type="entry name" value="TBC1_cilium_biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19853:SF1">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19853">
        <property type="entry name" value="WD REPEAT CONTAINING PROTEIN 3 WDR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="8 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="13">
        <location>
            <begin position="423"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="701"/>
            <end position="770"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1076" mass="125488" checksum="4853BC0E18EB266C" modified="2022-01-19" version="1">MASCDVGCREHGALWQRKHSPATGGVIVNIIHSATGYHSKAIRFLNVAFDSSGDSLLAGDHQGNIYVFDLNGNRFKLVQRTMQACTALAFNLRRKTEFLVALADYSVKCFDTETQELVSWMRGHDSSVSSISVHSSGRYAITTSTDTAQLWDLDTFQRKRKLNVRQSVGIQQVFFLPLSNTILSCFKDNSVFAWEFDTLHCKYQLPTAVEGSALHYKVFAVTRDGRIFVAGGKSNHLHLWCLESKQLVRIIQMPTEVRAVRHLEFLPDSFDGGSNQVLGVLSQDNIMRFISIETYKLLFVIGSHEEGISTAAISPSGRYIASVMENGSLNLYSVQALTQEVNKPPPPLLKVVEDWPKCKSEANKLTVRVTSGRSEQPRKSKGSKIQTRLLKVQMSTTLENKENELPGGLNKKRLQVLLKGYGEYPAKYRMFVWRSLLQLPENHLAFSSLIDKGTHSAFVNIQNEYPIKSRKLLRVLQRTLSALAHWSAIFGETPYIPLLAFPFVKLFQNNQLICFEVVATVIVNFCQHWFEYFPNPPVNILSMMENILAHHDKELLQHFIKYSVTSQVYAWPLLETLFSEVLTREEWLKVFDNIFSNHPSYFLMVVVAYIICSRAPLLLCNQSKDFEYFFHHRNNLDVNAVIKRAYHLMETTPPDIHPQRVLDDFVPLTKGQYPVFNKYPKFVVDYQTQERERIRQDEIEYLRERQLVHELEAKAQEQKAEDEAFYRKQELLQEAEEQRRKMLLEEEEKLAERRQRLAAVRRELKVKELQFLDASRRRFLKYQLDRREMELKRLDDDIARKVSMRDRETAAAVQDIEVRQMELESHRQLFEQRLIKDQERITQEMREETDDRQRKADLEDHIVQRWIETDREERQKAQLVAEENLAKVEQKCIDNEWRLQVLNKLRHDDQDRDKHYEEIAKLLHDNRVKEAELLKAMREAEEEKWEEVAWRKARLEEEQKAAAATDVHRKQFLEDEMNDALELDEKLQSGGGYFERLRDLKARRAERRVEFQVPKSGNICLNDLSASQSSSHGRRQELVRQERELMAEVRQLRQKLTARAHIRRPPALGAPTRWTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T3D8</accession>
    <name>A0A8C2T3D8_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mucosa-associated lymphoid tissue lymphoma translocation protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC107325680</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T3D8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005010371.1">
        <property type="protein sequence ID" value="ENSCJPP00005006597.1"/>
        <property type="gene ID" value="ENSCJPG00005006159.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000018044"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08783">
        <property type="entry name" value="Death_MALT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052039">
        <property type="entry name" value="Caspase-related_regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037940">
        <property type="entry name" value="MALT1_Death"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041077">
        <property type="entry name" value="MALT1_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033540">
        <property type="entry name" value="MALT1_IG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001309">
        <property type="entry name" value="Pept_C14_p20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22576">
        <property type="entry name" value="MUCOSA ASSOCIATED LYMPHOID TISSUE LYMPHOMA TRANSLOCATION PROTEIN 1/PARACASPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22576:SF27">
        <property type="entry name" value="PARACASPASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18703">
        <property type="entry name" value="MALT1_Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50208">
        <property type="entry name" value="CASPASE_P20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="106"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="202"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Caspase family p20" evidence="2">
        <location>
            <begin position="341"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="718"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="724"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="763" mass="84352" checksum="A44343ED3D067430" modified="2022-01-19" version="1">MGDWTLPIGSLGEEVVAQLCELLDTAGRGWRKLAEVAGAEKRFKCSEEELEMCSLKVLEPLGSPTQSLLQLLAERECTLWYLRGCLLRMGHTRAFQVLSGAVHNVIRITVQPESQVVAEGTRVSLSCWATGPSGLTYQWFCGKQEVPGATAPELLVDTAALPGLPQWFICRVSCGAAFAFSRWAHIQVKRSHSPESGSGYCPNMVGLQILQQPRPCCLAEGDPLVLECRAQGNPPPQYQWFRNRRPVEGARDPRLQVQLVTTAERGTYSCRVFNLFHELWSQEVDVEIGPRLFASGAPWQDGVGGRYRWWHRPIAVLGAVANTSLFTDSPEPGSSDQLYATDKVALLLGNMHYMHHKHLRAPMVDVHALGALLQQLDFKVVSLLDLRRDEMQMAVDEFLLLLDKGVYGLLYYAGHGYENFGTSFMVPIDAPGSYTSAHCLCVQHVLQRMQQRRTGLNIFLLDMCRKRNLNDDVVPQVGALEVTANIVFGYATCADAEAYELSQDELSNGVFVTFLKRWLLEDEKITVLLDKVAEDMGTLELTRGRQALELRSNLSERRALTDPICSSGRAESSARNLQWAKAHVLPESRQLRFDCGVTVQLGFAAEFSNIMIIYTRVLAAPGHIAECVARLTDLPEELDVDLKCINRESPEELGSPLVPTWSVTCPSCCLYSRLCGLQRLRQELTFTVCLQLRYRGGADFVEEQQVVSVGRPLISKLNLSPRDPSTAPASGGSGSPLSASPPDSWGNSPDVNLSPEVPGSHGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T490</accession>
    <name>A0A8C2T490_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Galactose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="15">2.7.7.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">GALT</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Plays an important role in galactose metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:13989"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="2.7.7.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="14">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 15">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.12" evidence="15"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2T490"/>
    <dbReference type="Ensembl" id="ENSCJPT00005009614.1">
        <property type="protein sequence ID" value="ENSCJPP00005006061.1"/>
        <property type="gene ID" value="ENSCJPG00005005705.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000016188"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome Z"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008108">
        <property type="term" value="F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-alpha-D-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00608">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000001">
        <property type="entry name" value="Galactose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000002">
        <property type="entry name" value="Galactose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001937">
        <property type="entry name" value="GalP_UDPtransf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019779">
        <property type="entry name" value="GalP_UDPtransf1_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005850">
        <property type="entry name" value="GalP_Utransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005849">
        <property type="entry name" value="GalP_Utransf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00209">
        <property type="entry name" value="galT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008724">
        <property type="entry name" value="PRK11720.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943">
        <property type="entry name" value="GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943:SF1">
        <property type="entry name" value="GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02744">
        <property type="entry name" value="GalP_UDP_tr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01087">
        <property type="entry name" value="GalP_UDP_transf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000808">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00117">
        <property type="entry name" value="GAL_P_UDP_TRANSF_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 15" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="7 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Galactose-1-phosphate uridyl transferase N-terminal" evidence="16">
        <location>
            <begin position="13"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="Galactose-1-phosphate uridyl transferase N-terminal" evidence="16">
        <location>
            <begin position="98"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Galactose-1-phosphate uridyl transferase C-terminal" evidence="17">
        <location>
            <begin position="217"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-UMP-histidine intermediate" evidence="12">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="36"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="13">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="13">
        <location>
            <begin position="111"/>
            <end position="112"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="13">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="13">
        <location>
            <begin position="193"/>
            <end position="195"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="13">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="348"/>
            <end position="349"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="353"/>
            <end position="354"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="13">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00056769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="394" mass="44948" checksum="0CC6857C2C8F5DFC" modified="2022-01-19" version="1">MEAAGGGGGAGFRASEHQHCRYNPLRDEWVLVSAHRVKRPWQGQLEKPPNEDVPRWDPKNPLCPGATRANGEVPRCTLILLPPVSLSPIPRLHFSPLQVNPHYEGTFVFPNDFPALQPDAPEPDDSGHPLFRAAAARGVCKVMCFHPHSDLTLPLMSLLEIRAVIDAWAELEAELGASYPWVQIFENKGAMMGCSNPHPHCQVWASSFLPNEARLEERTQRQHHRQHGVPMLLEYAEQEAQRKERLVVENEDWLVVVPYWATWPFQTLLLPRRHVLRLQDLCDSERDSLASIMRRLLIKYDNLFQVSFPYSMGWHGAPTGPHLQEDCGHWQLHAHYYPPLLRSATVRKFMVGYEMLAQAQRDLTPEQAAERLRALPEVHYKLRPQETVCDAAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T4J8</accession>
    <name>A0A8C2T4J8_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">WD repeat and FYVE domain-containing protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">WD40- and FYVE domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">WDFY1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Positively regulates TLR3- and TLR4-mediated signaling pathways by bridging the interaction between TLR3 or TLR4 and TICAM1. Promotes TLR3/4 ligand-induced activation of transcription factors IRF3 and NF-kappa-B, as well as the production of IFN-beta and inflammatory cytokines.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Early endosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T4J8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005009789.1">
        <property type="protein sequence ID" value="ENSCJPP00005006181.1"/>
        <property type="gene ID" value="ENSCJPG00005005798.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157731"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030054">
        <property type="term" value="C:cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005545">
        <property type="term" value="F:1-phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034141">
        <property type="term" value="P:positive regulation of toll-like receptor 3 signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034145">
        <property type="term" value="P:positive regulation of toll-like receptor 4 signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd15756">
        <property type="entry name" value="FYVE_WDFY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000285">
        <property type="entry name" value="WD repeat and FYVE domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000433">
        <property type="entry name" value="WD repeat and FYVE domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000105">
        <property type="entry name" value="WD repeat and FYVE domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042234">
        <property type="entry name" value="WDFY1/WDFY2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042733">
        <property type="entry name" value="WDFY1_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46189">
        <property type="entry name" value="LD41958P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46189:SF2">
        <property type="entry name" value="WD REPEAT AND FYVE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 13" id="KW-0853">WD repeat</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="59"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="234"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="277"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="15">
        <location>
            <begin position="320"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00058630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00080348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="449" mass="50541" checksum="FBB03F1AC131295A" modified="2022-01-19" version="1">MLYGRLAPDTTSWRCAPLHGTARPGGAARAPSAEGRRANMAAEIHSRPQSSRPVLLSKVEGHQDVVSAALLIPKEDGVITASEDRTIRVWLKRDSGQYWPSIYHTMSSPCSAMAYHHDSRRIFVGQDNGAIMEFHISEDFNKMNFVKTYPAHQNRVSAITFCLTSEWVISTGHDKCVSWMCTRSGSMLGRHYFTSWASCLQYDHETRYAFVGDYSGQITLLKLEQNTCSIITTLKGHEGSITSLWWDPVQRLLFSGASDHSIIMWDIGGRKGRTLLLQGHHDKVQAICYIQLTRQLVSCSADGGIAVWNMDISREEAPQWLESDSCQKCEQPFFWNIKQMWDTKTLGLRQHHCRKCGQAVCGKCSTKRSSYPIMGFEFQVRVCDSCFESIKDEDRTSLATFHEGKHNISHMSMDISRGLMVTCGSDRIVKIWDMTPVVGCSLATGFSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T670</accession>
    <name>A0A8C2T670_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Centrosomal protein 192</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">CEP192</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="Ensembl" id="ENSCJPT00005013149.1">
        <property type="protein sequence ID" value="ENSCJPP00005008708.1"/>
        <property type="gene ID" value="ENSCJPG00005007660.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00510000048187"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000242">
        <property type="term" value="C:pericentriolar material"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120098">
        <property type="term" value="C:procentriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120099">
        <property type="term" value="C:procentriole replication complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019902">
        <property type="term" value="F:phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051298">
        <property type="term" value="P:centrosome duplication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090222">
        <property type="term" value="P:centrosome-templated microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071539">
        <property type="term" value="P:protein localization to centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009617">
        <property type="term" value="P:response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054085">
        <property type="entry name" value="Cep192-like_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054086">
        <property type="entry name" value="Cep192-like_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054089">
        <property type="entry name" value="Cep192-like_D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054091">
        <property type="entry name" value="Cep192-like_D5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054092">
        <property type="entry name" value="Cep192-like_D6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054087">
        <property type="entry name" value="Cep192-like_D7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054088">
        <property type="entry name" value="Cep192-like_D8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057662">
        <property type="entry name" value="CEP192_Aurora-A_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054090">
        <property type="entry name" value="Cep192_Spd-2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039103">
        <property type="entry name" value="Spd-2/CEP192"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16029">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 192 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16029:SF11">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 192 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25763">
        <property type="entry name" value="Aurora-A_bind_CEP192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22060">
        <property type="entry name" value="Cep192_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22064">
        <property type="entry name" value="Cep192_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22067">
        <property type="entry name" value="Cep192_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22073">
        <property type="entry name" value="Cep192_D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22074">
        <property type="entry name" value="Cep192_D5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22076">
        <property type="entry name" value="Cep192_D6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22065">
        <property type="entry name" value="Cep192_D7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22066">
        <property type="entry name" value="Cep192_D8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cep192-like" evidence="2">
        <location>
            <begin position="823"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="domain" description="Cep192-like" evidence="3">
        <location>
            <begin position="946"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="domain" description="Cep192-like" evidence="6">
        <location>
            <begin position="1102"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="domain" description="Cep192/Spd-2-like" evidence="7">
        <location>
            <begin position="1214"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="domain" description="Cep192-like" evidence="8">
        <location>
            <begin position="1337"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="domain" description="Cep192-like" evidence="8">
        <location>
            <begin position="1421"/>
            <end position="1484"/>
        </location>
    </feature>
    <feature type="domain" description="Cep192-like" evidence="9">
        <location>
            <begin position="1545"/>
            <end position="1646"/>
        </location>
    </feature>
    <feature type="domain" description="Cep192-like" evidence="4">
        <location>
            <begin position="1711"/>
            <end position="1783"/>
        </location>
    </feature>
    <feature type="domain" description="Cep192-like" evidence="5">
        <location>
            <begin position="1785"/>
            <end position="1875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="506"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="566"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="506"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF22067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005008708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1879" mass="208554" checksum="F246E2F9DA6BE5B3" modified="2022-01-19" version="1">MLMGEYWYIWRYSRPAWMPTCAKWCDAPHSVVYQNEEGKWVTDLAYYTSFDEEQDLNLSEDDKINEFITGSEAAAMIAQDQEEFEKTHRLLQPSFGYHITSPKTRQPVALLRQFDFTRRNLPGEMGRDYNLEVTLSSYSSALLRIGSVQRQEVRLQRRREANVENITFDMEKYLKKTDESGHESERESIAKREAPVQNSMSESTLLAKVRNKETLVEDFLSDHNEQQLTEKQFLSYFNAESGTQNSSSDASKHEDRTANSIKYSEKLSDIISSKHLQLMSATLKSDMPDTQTLPNRNKAQACETPVAVKRETAQRLLFAQQADNLTSRCSKEGGGTVKNTVPEPCNDFERNTRNVSLSNGKATKEPGKCVFVSPTRTAPVQKLSTDEEMQSSKVEERTKESCAAGSGSVKHVTFDKHSPTSQNSTEHQPVLPECDLQPLEDEQYSFRPSTSPLIHSSPSDASGTACSGSEADVICTSQYPKSPCKEDTISQSVNSSPSMSRLTYVSESDSTLKNTSVTHDPEIRWSENASELSTTIIRASPTPSQEQTNKLEDYLCQRNRKGVQFSVDQKSKENELAHPERKLEGQGQELSKEDLPKNERQLGSAASRVAATLKELEPALSALASKFCVFQPLPVNTGAQEVWQDHTNKAQTQGLPSLNTLPVYPGLRACIPVNQNTPGEQYIPISSFKSHVTTSESQTVSSVPTLLPGHSLATTQFAQHHLGNVPSTGNKILPQFHGCSSAGFSVPPSGLPYSSISAELVENSVPVGIPLGSNIGPGSLGTAALCHPQSASWNKNILNIRSYTAQHPGTGRKEWDFSMSSGVGHVKVPEELKFPNACCVGIASQTVLSIFNPTERWLQVSIGILSISVNGEKVDPAKYQCLVFKNKTIVGPHSTDDLKILFLPCHPGIFQCILSVSSWSVSADAEIVVQAEALSSRVVLTAVAENPNLEVETGKQDYLDFGDLTSGSWKALPLKIINKTHAFVPIRLIINANAVAWRCFTFSKEPVNSSNEQSLQRDAVSQAAAPSVVNHVIHASYDGQDPEVLTVWVLFHAPKKQISCSDTLGPAEEFLARVDVEVDSPGPSSVIQSVLLRARAGTARIHAPKDLQTIHLSAGVDSTAKQQLPLKNAGNIGVNLKLKVEQDSCFSVEPDDLFLLPGEEREVTVKFSPKNVVSTQSVLKILVLPSGPQYEVVIKGETESLENRPVPTAAADIPPILSNKQFVAWGGVKLGESVQQKLALRNNSPSVTQHLRLVIRGQDQDCFQLQSIFGSEERLTSTWELKIRPREDTNIYLMFTPTRVTSFFAKLEIKHLGIISQPGIKFTIPLSGYGGTSSVILESVKKLTDGYTLTLDGLLPSRLKRVSFRIRNTGSRAAYVKALCFANLQTKTVVDPQVMTVSPDKFILREGTHEVSIMSKLYCLKSMMRDFEVAKPVVPENSLLRNIVFDEEFQGEKLVTEVCDIPRGTNDIRLFYANMRKIILTVVGHFVVNQDDFQQPSEHHLESNRSENAARLINATLDVLPVKGPQGPPLHEKINDGVQNKVDAEQTWSVKPEELTLLPPSISGTADTGHVEIVNSSSRMLTFELSWPAHCLTITPQHGVIEPESRALILVSPNPSLATKPSVIPWSGLIYVHCDKEQKFIKVQIREAQDASGTSSPPRRRDLFTLQSASPAVHVAKPLSAHPLTKMEIKNRTIIFPKTRAGECTDLLFSAMDETGSVYRATYSAFRCYRISGTLEAHGKEKVAFMFLPIENGDYSQFWDLECHPVENPSWKHKLRFQLSGETVKEVYAFLPTRVGESRTLKVNLRNNSFRTQMLKFSIPREPFYIKHTRYSLRSRHYINVPVRFRPQAEGIFESILVVYTSKYGNINIRLCGRAIARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T690</accession>
    <name>A0A8C2T690_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T690"/>
    <dbReference type="Ensembl" id="ENSCJPT00005010760.1">
        <property type="protein sequence ID" value="ENSCJPP00005006901.1"/>
        <property type="gene ID" value="ENSCJPG00005006388.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163916"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001792">
        <property type="entry name" value="Leucine-rich repeat protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF52">
        <property type="entry name" value="LEUCINE-RICH REPEAT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="164" mass="18810" checksum="EB82049E46C4058C" modified="2022-01-19" version="1">VLCLKKLRKLDLSHNHIKQLPATIGDLVFLQELNLHDNHLESFSSALCCSTLQKSLQCLDLSQNKIKALPIQFCQLRELVNLKLDDNELIRLPFKMGQLDQLRFLSAARNKLPFLPSDFRKLCLENLDLFGNPFEQPNPLLPNIHLKIPLTLLECAARATVNYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T6K9</accession>
    <name>A0A8C2T6K9_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fas activated serine/threonine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FASTK</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T6K9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005011882.1">
        <property type="protein sequence ID" value="ENSCJPP00005007734.1"/>
        <property type="gene ID" value="ENSCJPG00005007008.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234607"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035770">
        <property type="term" value="C:ribonucleoprotein granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000963">
        <property type="term" value="P:mitochondrial RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044528">
        <property type="term" value="P:regulation of mitochondrial mRNA stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013579">
        <property type="entry name" value="FAST_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050870">
        <property type="entry name" value="FAST_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010622">
        <property type="entry name" value="FAST_Leu-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013584">
        <property type="entry name" value="RAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21228:SF4">
        <property type="entry name" value="FAS-ACTIVATED SERINE_THREONINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21228">
        <property type="entry name" value="FAST LEU-RICH DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06743">
        <property type="entry name" value="FAST_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08368">
        <property type="entry name" value="FAST_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08373">
        <property type="entry name" value="RAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00952">
        <property type="entry name" value="RAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51286">
        <property type="entry name" value="RAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RAP" evidence="4">
        <location>
            <begin position="492"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="198"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="546"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005007734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="576" mass="63602" checksum="C4E99ECDD692850A" modified="2022-01-19" version="1">MLRLLPWLRALSRPRGPAERSGAAMHPVHPVHPVHPVHPACYCAGRARPRALLLPLDPYGHGLLHAIPADAGRSRGHGKRKSWNFIHEKMSYDTFFTMKRLIERSRSVGEVLRWVTQNPGKVSASHYPIALHKLGQLLQQQQGPAALNGESRRPGPVLEQPEFQTLCQAIISGCSKFDNFSIVNCLYAAAALGEWPGRGSDGIPQPPGPLQPEGRVHGVQQRDAAAPLQPSPPGRVVPQQLGAAPGEGAAPAENLTPYTMALIAKYVARHRLREPRLLDTIANFLLKRGEQLDSKVIQKLVFPFSRMNYRPSNHSELFPKLEAILEQKAGSSPLATVNILMSMFQLSHFPQSVLHQVFSPAFITNVMSTPYALIVRRYLSLLDAAVELEFHDYSGPRLDPRYRVLMFEHALTADEANRKYSYKGLVAEALRQLVGEECYRQDEVLPPGYCTGNCCVLALTSDLQDFAPFAPEPPGRPGCLHGGVTLLCPCRVVLSVNDKWHYCQNSDILVGSRAMRDRHLRLLGYCLVQLPYTELEKVSGIEEAKLYLPAQPPPGGRRGEEGEGGARSPRPKGGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T6M6</accession>
    <name>A0A8C2T6M6_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Choline/ethanolamine transporter FLVCR1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Heme transporter FLVCR1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">FLVCR1</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Uniporter that mediates the transport of extracellular choline and ethanolamine into cells, thereby playing a key role in phospholipid biosynthesis. Choline and ethanolamine are the precursors of phosphatidylcholine and phosphatidylethanolamine, respectively, the two most abundant phospholipids. Transport is not coupled with proton transport and is exclusively driven by the choline (or ethanolamine) gradient across the plasma membrane. Also acts as a heme b transporter that mediates heme efflux from the cytoplasm to the extracellular compartment.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>choline(out) = choline(in)</text>
            <dbReference type="Rhea" id="RHEA:32751"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ethanolamine(in) = ethanolamine(out)</text>
            <dbReference type="Rhea" id="RHEA:32747"/>
            <dbReference type="ChEBI" id="CHEBI:57603"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>heme b(in) = heme b(out)</text>
            <dbReference type="Rhea" id="RHEA:75443"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the major facilitator superfamily. Feline leukemia virus subgroup C receptor (TC 2.A.1.28.1) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015712780.1">
        <property type="nucleotide sequence ID" value="XM_015857294.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T6M6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005012646.1">
        <property type="protein sequence ID" value="ENSCJPP00005008308.1"/>
        <property type="gene ID" value="ENSCJPG00005007463.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107311068"/>
    <dbReference type="KEGG" id="cjo:107311068"/>
    <dbReference type="CTD" id="28982"/>
    <dbReference type="GeneTree" id="ENSGT01030000234625"/>
    <dbReference type="OrthoDB" id="422206at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015220">
        <property type="term" value="F:choline transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034228">
        <property type="term" value="F:ethanolamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015232">
        <property type="term" value="F:heme transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001568">
        <property type="term" value="P:blood vessel development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042733">
        <property type="term" value="P:embryonic digit morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048704">
        <property type="term" value="P:embryonic skeletal system morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043249">
        <property type="term" value="P:erythrocyte maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060323">
        <property type="term" value="P:head morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097037">
        <property type="term" value="P:heme export"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006839">
        <property type="term" value="P:mitochondrial transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035264">
        <property type="term" value="P:multicellular organism growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046620">
        <property type="term" value="P:regulation of organ growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048536">
        <property type="term" value="P:spleen development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000184">
        <property type="entry name" value="Feline leukemia virus subgroup C receptor-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049680">
        <property type="entry name" value="FLVCR1-2_SLC49-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924:SF2">
        <property type="entry name" value="HEME TRANSPORTER FLVCR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0265">Erythrocyte maturation</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="357"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="380"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="417"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="446"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="19">
        <location>
            <begin position="64"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00035075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00036811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00046338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00060240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00068050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00080886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005008308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="506" mass="54722" checksum="F4855C1EFD7E7474" modified="2022-01-19" version="1">MVEDGSEEEEGEAEGERGEMLGASQHNGFLPGKEAENGGPGGCAALGAGGIQLETRLSRRRLAVLAVFSCYSLVNAFQWIQYSSLNNVFVRFYGVSFTEIDWLSMVYMVAYVPLILPATWLLDARGLRLTALLGSGLNALGAWLKCASVAPGRYALTMAAQAVCAVAQVFILGLPSRIASVWFGPAEVSTACSVAVLGNQLGTAIGFLLPPVLVPNTPDDIDLMAHNISIMFYGTAIVSTLLFFLTGVVFEEKPKYPPSHSQALLQALPPEDYSYKQSIINLVRNVPFVLLLISYGIMTGTFYSVSTLLNQMIVTHYEGEEVNAGRIGLTLVVAGMVGSIICGLWLDYTKTYKQTTLIVYILSFIGMVVFTFTLDLGYLIVVFVTGGVLGFFMTGYLPLGFEFAVEITYPESEGTSSGLLNASAQIFGIVFTLVQGKLTTDYSPRAGNLFLCAWLFVGIILTALIKSDLRRHNVNSGIMNMDVKAVPVDNPVERETCTALKIQSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T726</accession>
    <name>A0A8C2T726_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transmembrane protein 71</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">TMEM71</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015711852.1">
        <property type="nucleotide sequence ID" value="XM_015856366.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T726"/>
    <dbReference type="Ensembl" id="ENSCJPT00005014086.1">
        <property type="protein sequence ID" value="ENSCJPP00005009424.1"/>
        <property type="gene ID" value="ENSCJPG00005008273.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107310575"/>
    <dbReference type="CTD" id="137835"/>
    <dbReference type="GeneTree" id="ENSGT00390000011144"/>
    <dbReference type="OrthoDB" id="8961338at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027975">
        <property type="entry name" value="TMEM71"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35255">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35255:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15121">
        <property type="entry name" value="TMEM71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005009424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="283" mass="31274" checksum="C00BFCDEC160E82C" modified="2022-01-19" version="1">MYGISHVTSTPRGGSTAFDGDHRHILSEHIFQRCCSTSPLRDTLFTCRRSPRLLSNGYYVLTEDSFLSDEDGNITLSPSQTSVTYKENLVRIFRRRKKIRRSLASLFSLSASSQWLSSTIINTLDSSHVDDVDYPWPDKCSKPEASQTDTGNSDFSCEYNILVPQGQIPASIGASLTKDKKFIEPGKSLCASPSCSLFMINGNEDTLNKAESNTVPNFLSQIAALMVCLIISVCTRYFLGGLSAILLLIILVFLLSQDAALSSFFSLVTSFKTTKFGIIEKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T7D6</accession>
    <name>A0A8C2T7D6_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase K family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T7D6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005014141.1">
        <property type="protein sequence ID" value="ENSCJPP00005009466.1"/>
        <property type="gene ID" value="ENSCJPG00005008303.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000170763"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026770">
        <property type="entry name" value="RNase_K"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31733">
        <property type="entry name" value="RIBONUCLEASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005009466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="100" mass="10745" checksum="86C7A066B6853A8D" modified="2022-01-19" version="1">METPIGTQNGPPHGNPVCPPPHHHGPRPDPHPHPPTPIPFPTFWGVAMVSLLCCGPKLAACGIVLSAWGVVMLVLLGIFFNVHSAVLIEDVPFTEEDFNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T900</accession>
    <name>A0A8C2T900_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Retinoic acid receptor responder protein 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Chemerin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">RARRES2</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015708261.1">
        <property type="nucleotide sequence ID" value="XM_015852775.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015708263.1">
        <property type="nucleotide sequence ID" value="XM_015852777.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T900"/>
    <dbReference type="Ensembl" id="ENSCJPT00005013526.1">
        <property type="protein sequence ID" value="ENSCJPP00005009011.1"/>
        <property type="gene ID" value="ENSCJPG00005007979.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107308699"/>
    <dbReference type="KEGG" id="cjo:107308699"/>
    <dbReference type="CTD" id="5919"/>
    <dbReference type="GeneTree" id="ENSGT00390000016226"/>
    <dbReference type="OrthoDB" id="9894305at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050921">
        <property type="term" value="P:positive regulation of chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050994">
        <property type="term" value="P:regulation of lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029562">
        <property type="entry name" value="Chemerin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046350">
        <property type="entry name" value="Cystatin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15106">
        <property type="entry name" value="RETINOIC ACID RECEPTOR RESPONDER PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15106:SF2">
        <property type="entry name" value="RETINOIC ACID RECEPTOR RESPONDER PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54403">
        <property type="entry name" value="Cystatin/monellin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="6" id="KW-0221">Differentiation</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0395">Inflammatory response</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034264828" description="Retinoic acid receptor responder protein 2" evidence="10">
        <location>
            <begin position="18"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005009011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="162" mass="18138" checksum="FB32764FA479624C" modified="2022-01-19" version="1">MKLLLGIAVAVLALADAGQSPLQRRVVKDVLDYFHSRSNVQLLFREQSVEGAVERVDSSGTYVQLRLNLAQTACKKQTQRRQNCRIIESKRKPACLACYKFDNSDVPRVLDKYYNCGPSHHLVVKEIKHRDEAECRAVEEAGKASDALYLPGMFAFSKGLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TA00</accession>
    <name>A0A8C2TA00_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="27">Ras-related protein Rab-23</fullName>
            <ecNumber evidence="7">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="28" type="primary">RAB23</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="28" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="28" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="26">Interacts with SUFU.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasmic vesicle</location>
            <location evidence="3">Autophagosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasmic vesicle</location>
            <location evidence="5">Phagosome membrane</location>
            <topology evidence="5">Lipid-anchor</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Endosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="7"/>
    <dbReference type="RefSeq" id="XP_015714694.1">
        <property type="nucleotide sequence ID" value="XM_015859208.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015714697.1">
        <property type="nucleotide sequence ID" value="XM_015859211.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TA00"/>
    <dbReference type="Ensembl" id="ENSCJPT00005012837.1">
        <property type="protein sequence ID" value="ENSCJPP00005008474.1"/>
        <property type="gene ID" value="ENSCJPG00005007563.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107312097"/>
    <dbReference type="KEGG" id="cjo:107312097"/>
    <dbReference type="CTD" id="51715"/>
    <dbReference type="GeneTree" id="ENSGT00940000155064"/>
    <dbReference type="OrthoDB" id="6585768at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030054">
        <property type="term" value="C:cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030670">
        <property type="term" value="C:phagocytic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006968">
        <property type="term" value="P:cellular defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097094">
        <property type="term" value="P:craniofacial suture morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046039">
        <property type="term" value="P:GTP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042308">
        <property type="term" value="P:negative regulation of protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04106">
        <property type="entry name" value="Rab23_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000669">
        <property type="entry name" value="Ras-related protein Rab-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034114">
        <property type="entry name" value="Rab23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="24" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="9" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="16" id="KW-0967">Endosome</keyword>
    <keyword evidence="20" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="22" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="21" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0488">Methylation</keyword>
    <keyword evidence="15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-0636">Prenylation</keyword>
    <keyword evidence="19" id="KW-0653">Protein transport</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00047660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00062634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00067823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005008474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="237" mass="26809" checksum="4A9E9046BC691E8B" modified="2022-01-19" version="1">MLEEDMEVAIKVVVVGNGAVGKSSMIQRYCKGIFTKDYKKTIGVDFLERQIQVNDEDVRLMLWDTAGQEEFDAITKAYYRGAQACVLVFSTTDRESFKAIPTWKEKVMTEVGDIPTVLVQNKIDLLDDSCIKNEEAEALAKKLKLRFYRASVKEDLNVTEVFKYLADKYLQRLKQQTAEEPELVHTSSNKIGVFNTAIGSHPNQNSNTLNGGDVINLRPNKQRTKKSRSLFSNCSIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TBQ6</accession>
    <name>A0A8C2TBQ6_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glutathione transferase</fullName>
            <ecNumber evidence="4">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC107321445</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GST superfamily. Theta family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2TBQ6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005014594.1">
        <property type="protein sequence ID" value="ENSCJPP00005009812.1"/>
        <property type="gene ID" value="ENSCJPG00005008584.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163205"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03183">
        <property type="entry name" value="GST_C_Theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03050">
        <property type="entry name" value="GST_N_Theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000008">
        <property type="entry name" value="Glutathione S-transferase theta-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040077">
        <property type="entry name" value="GST_C_Theta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040075">
        <property type="entry name" value="GST_N_Theta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051369">
        <property type="entry name" value="GST_Theta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43917">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43917:SF9">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE THETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="9">
        <location>
            <begin position="104"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005009812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="250" mass="28516" checksum="4A5FE6E96DB1B07D" modified="2022-01-19" version="1">MGLELYLDLLSQPCRAVYIFARCNNIPFEFKRVELMKGERGWEGAAAPDSSGRGIPRTEEFRKVNVLMKVPALKDGSFTLAESVAILMYLARKFKTPDHWYPSDLQKQARIDEYLSWHVCFPPCQMLVPLLTGQPLPPEKLEGATEELNVVLNQFEEKFLQDKPFIAGSDISLADLVALVELMQPVASGYDLFAERPKLAEWRRRVEEAVGKQLFQEAHEEILNAKSVTADKIAPELREHFKQQLLKQVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TCJ5</accession>
    <name>A0A8C2TCJ5_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome production factor 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Brix domain-containing protein 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Ribosome biogenesis protein RPF1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">RPF1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">May be required for ribosome biogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015725903.1">
        <property type="nucleotide sequence ID" value="XM_015870417.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TCJ5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005014188.1">
        <property type="protein sequence ID" value="ENSCJPP00005009507.1"/>
        <property type="gene ID" value="ENSCJPG00005008339.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107317558"/>
    <dbReference type="KEGG" id="cjo:107317558"/>
    <dbReference type="CTD" id="80135"/>
    <dbReference type="GeneTree" id="ENSGT00940000153231"/>
    <dbReference type="OrthoDB" id="10253204at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10480:FF:000002">
        <property type="entry name" value="Ribosome production factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10480">
        <property type="entry name" value="Probable brix-domain ribosomal biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044281">
        <property type="entry name" value="IMP4/RPF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734:SF3">
        <property type="entry name" value="RIBOSOME PRODUCTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Brix" evidence="9">
        <location>
            <begin position="123"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005009507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="330" mass="38439" checksum="5588C054365FBD12" modified="2022-01-19" version="1">MAGGDAVSGPGTGAAGQDVEPAAPERVLFPPTFSVSEIKNKQRRHFMFLRWKQQQRKEKLALKKKRRKEREALGDKAPPKAVPKTIENQRIYDETTVDPNDEEVAFDIANDEFAPYFNRQTVPKILITTSDRPRGRTVRFCEQLSTVIPNSHVYYRRGLALKRIIPQCIARDFTDLIVINEDRKIPNGLVLSHLPDGPTAHFRMSSVRLRKEIKRKGKEPTEHVPEVILNNFTTRLGHSIGRMFASLFPHDPQFIGRQVATFHNQRDYIFFRFHRYIFKSEKKVGIQELGPRFTLKLRSLQKGTFDSKFGEYEWIHKRREMDTSRRKFHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TD64</accession>
    <name>A0A8C2TD64_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">SMARCB1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the multiprotein chromatin-remodeling complexes SWI/SNF.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the SNF5 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TD64"/>
    <dbReference type="Ensembl" id="ENSCJPT00005014537.1">
        <property type="protein sequence ID" value="ENSCJPP00005009771.1"/>
        <property type="gene ID" value="ENSCJPG00005008552.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00440000038585"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001650">
        <property type="term" value="C:fibrillar center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043073">
        <property type="term" value="C:germ cell nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071565">
        <property type="term" value="C:nBAF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071564">
        <property type="term" value="C:npBAF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016514">
        <property type="term" value="C:SWI/SNF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002039">
        <property type="term" value="F:p53 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001164">
        <property type="term" value="F:RNA polymerase I core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030957">
        <property type="term" value="F:Tat protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070365">
        <property type="term" value="P:hepatocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043923">
        <property type="term" value="P:host-mediated activation of viral transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006337">
        <property type="term" value="P:nucleosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902661">
        <property type="term" value="P:positive regulation of glucose mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901838">
        <property type="term" value="P:positive regulation of transcription of nucleolar large rRNA by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0039692">
        <property type="term" value="P:single stranded viral RNA replication via double stranded DNA intermediate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045815">
        <property type="term" value="P:transcription initiation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd21086">
        <property type="entry name" value="WH_NTD_SMARCB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048664">
        <property type="entry name" value="INI1_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017393">
        <property type="entry name" value="Sfh1/SNF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006939">
        <property type="entry name" value="SNF5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10019">
        <property type="entry name" value="SNF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21459">
        <property type="entry name" value="INI1_DNA-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04855">
        <property type="entry name" value="SNF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038126">
        <property type="entry name" value="SWI_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0010">Activator</keyword>
    <keyword evidence="4 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SWI/SNF Subunit INI1 DNA binding" evidence="9">
        <location>
            <begin position="13"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR038126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005009771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="424" mass="48796" checksum="C6D4A3C154DEFB26" modified="2022-01-19" version="1">MMMMALSKTFGQKPVKFQLEEDGEFYMIGSEVGNYLRMFRGSLYKRYPSLWRRLATVEERKKIVASSHENQRSHSPRRYHGYTTLATSVTLLKASEVEEILDGNDEKYKAVSISTEPPTYLREQKAKRNNQWVPTLPNSSHHLDAVPCSTTINRNRMGRDKKRTFPLCFDDHDPAVIHENASQPEVLVPIRLDMEIDGQKLRDAFTWNMNEKLMTPEMFSEILCDDLDLNPLTFVPAIASAIRQQIESYPTDSILEDQSDQRVIIKLNIHVGNISLVDQFEWDMSEKENSPEKFALKLCSELGLGGEFVTTIAYSIRGQLSWHQKTYAFSENPLPTVEIAIRNTGDADQWCPLLETLTDAEMEKKIRDQDRNTRCCPWFSSHSGLSLRQKLKALMFLYSLLSANWQDFKLAYHNNLTALFASGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TDE5</accession>
    <name>A0A8C2TDE5_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Progesterone receptor membrane component 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">PGRMC2</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015716787.1">
        <property type="nucleotide sequence ID" value="XM_015861301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TDE5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005014701.1">
        <property type="protein sequence ID" value="ENSCJPP00005009867.1"/>
        <property type="gene ID" value="ENSCJPG00005008640.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107313220"/>
    <dbReference type="KEGG" id="cjo:107313220"/>
    <dbReference type="CTD" id="10424"/>
    <dbReference type="GeneTree" id="ENSGT00940000159744"/>
    <dbReference type="OrthoDB" id="547796at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015232">
        <property type="term" value="F:heme transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060612">
        <property type="term" value="P:adipose tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000003">
        <property type="entry name" value="membrane-associated progesterone receptor component 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF24">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="4">
        <location>
            <begin position="75"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005009867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="195" mass="21546" checksum="2D0160DE5603CC10" modified="2022-01-19" version="1">MADGGDGRLRTAGSGGHGGAGRSVGGGMLLYAGLLALALLAAYCLYLRWRKRSGPGDAAQPSQAAPLPRMKRRDFSLEQLREFDGIRNPRILLAVNGKVFDVTKGSKFYGPEGPYGIFAGRDASRGLATFCLDKDALRDEYDDLSDLNAVQMESVREWEMQFKEKYDYVGRLLKPGEEPSEYTDEEDTKDHTKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TES6</accession>
    <name>A0A8C2TES6_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">PTPN5</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="3.1.3.48" evidence="1"/>
    <dbReference type="RefSeq" id="XP_015719692.1">
        <property type="nucleotide sequence ID" value="XM_015864206.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032300888.1">
        <property type="nucleotide sequence ID" value="XM_032444997.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032300889.1">
        <property type="nucleotide sequence ID" value="XM_032444998.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032300891.1">
        <property type="nucleotide sequence ID" value="XM_032445000.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032300892.1">
        <property type="nucleotide sequence ID" value="XM_032445001.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032300893.1">
        <property type="nucleotide sequence ID" value="XM_032445002.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032300894.1">
        <property type="nucleotide sequence ID" value="XM_032445003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TES6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005018316.1">
        <property type="protein sequence ID" value="ENSCJPP00005012681.1"/>
        <property type="gene ID" value="ENSCJPG00005010769.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107314697"/>
    <dbReference type="KEGG" id="cjo:107314697"/>
    <dbReference type="CTD" id="84867"/>
    <dbReference type="GeneTree" id="ENSGT00940000159916"/>
    <dbReference type="OrthoDB" id="9993594at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030054">
        <property type="term" value="C:cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001784">
        <property type="term" value="F:phosphotyrosine residue binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14613">
        <property type="entry name" value="PTPc-N5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000020">
        <property type="entry name" value="Tyrosine-protein phosphatase non-receptor type 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008356">
        <property type="entry name" value="Tyr_Pase_KIM-con"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46198">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46198:SF1">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01778">
        <property type="entry name" value="KIMPTPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="8">
        <location>
            <begin position="260"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="9">
        <location>
            <begin position="432"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="5">
        <location>
            <position position="456"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="421"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="456"/>
            <end position="462"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="500"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR608356-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR608356-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005012681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="525" mass="59977" checksum="5AE327BD82ACDFB7" modified="2022-01-19" version="1">MESMDEAEGQQEQLNRKEQSLITSQKTALLAWGAWWNGLMTGDSMYLFVLSQILLLCMMLWYSTYGTISATQNAFDMLSYLLTPFELFLSDQGVDLTRIGNVVVSYILLSLASLGLLLVGSLFWHLLRARPDPPFPQQEDRRQSVSRQPSFTYSEWTEDKNEDDFLDLDPVPETPVFDCVMDIKVETDPATLTVKSVGLQERRGSNVSLTLDMCTPGCSEQGFGYIMSPREQSAQEYLQSASNILTEEELHKKALDPFILQAEFFEIPMNFVDPKEYDIPGLVRKNRYKTILPNPHSRVCLTSADQDDPLSSYINANYIRGYGGEEKVYIATQGPIVNTVSDFWRMVWQERSPIIVMITNIEEMNEKCTEYWPEEQIMYEGIEIVVNQVIQADDYRLRLITLKKGEEVRNLKHYWYTSWPDQKTPDQAPPLLQLVLEVEEAMQSAEEKNAPVIVHCSAGIGRTGCFIATSVCCKQLKNEGIVDILRTTCQLRLDRGGMIQTCEQYQFVHHVMSLYGKQLSRAAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TEV6</accession>
    <name>A0A8C2TEV6_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="24">Ethanolaminephosphotransferase 1</fullName>
            <ecNumber evidence="20">2.7.8.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="25">Selenoprotein I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="primary">LOC107310144</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="28" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="28" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="23">Ethanolaminephosphotransferase that catalyzes the transfer of phosphoethanolamine (PE) from CDP-ethanolamine to lipid acceptors, the final step in the synthesis of PE via the 'Kennedy' pathway. PE is the second most abundant phospholipid of membranes in mammals and is involved in various membrane-related cellular processes. The enzyme is critical for the synthesis of several PE species and also catalyzes the synthesis of plasmanyl-PE, a lipid required for proper myelination and neurodevelopment, from 1-alkyl-2-acylglycerol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>1-O-alkyl-2-acyl-sn-glycerol + CDP-ethanolamine = a 1-O-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36187"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:52595"/>
            <dbReference type="ChEBI" id="CHEBI:57876"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:60520"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:36188"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>CDP-ethanolamine + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32943"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57876"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="2.7.8.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:32944"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="19">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 26">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.1" evidence="20"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2TEV6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005016977.1">
        <property type="protein sequence ID" value="ENSCJPP00005011610.1"/>
        <property type="gene ID" value="ENSCJPG00005009984.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183117"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004307">
        <property type="term" value="F:ethanolaminephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000006">
        <property type="entry name" value="Putative ethanolaminephosphotransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014472">
        <property type="entry name" value="CHOPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414">
        <property type="entry name" value="ETHANOLAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414:SF35">
        <property type="entry name" value="SELENOPROTEIN I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015665">
        <property type="entry name" value="CHOPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="17" id="KW-0464">Manganese</keyword>
    <keyword evidence="15 27" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="18" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 26" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 27" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 27" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="129"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="328"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="358"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="382"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00037891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00038986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00052094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00059224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00070294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00083013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005011610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="423" mass="47749" checksum="B8426AF920203397" modified="2022-01-19" version="1">MANRSTIFTESQNCRGWKGPLEIIESNPPAKAGSLHHVTQVGVQAGLEYLQRRRLHHLPGQPYSAVDTNPLSVYVMQPIWNKIIKIVPLWIAPNLLTFSGFVMILVNYFLISFYDWDYTASGNPGRVPTWVWLFSAFTTFCAYALDSIDGKHARRTQSSSPLGELFDHGLDSWATSIFVLSFFSVCSRDNGKTGVSVYTMYMYLSIVLFNFMCSHWEKYNTGVLFLPWGYDLSQVLIAAYLLTGIVGVEVWQKPFLLGYYITDILVILLIGKCLNPWRTLLAHLRKTLKNDSLYEGLLPLVSPLLLFMLLTVWVVLSPGNILAKQPRLFLWMVGVTFSNVICKVIICQMSSTQPELLHWFLFPLALVVYAAISGLLGQAEEAVLGAFTALVTAAHVHYGICVGRQLSEHFNIYIFSLKKRVQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TG33</accession>
    <name>A0A8C2TG33_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="25">Poly [ADP-ribose] polymerase</fullName>
            <shortName evidence="25">PARP</shortName>
            <ecNumber evidence="25">2.4.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="29" type="primary">TNKS</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="29" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="29" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>NAD(+) + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H(+).</text>
            <dbReference type="EC" id="2.4.2.30"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Chromosome</location>
            <location evidence="4">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="22">Belongs to the ARTD/PARP family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.-" evidence="25"/>
    <dbReference type="RefSeq" id="XP_015717138.1">
        <property type="nucleotide sequence ID" value="XM_015861652.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TG33"/>
    <dbReference type="Ensembl" id="ENSCJPT00005019061.1">
        <property type="protein sequence ID" value="ENSCJPP00005013231.1"/>
        <property type="gene ID" value="ENSCJPG00005010649.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107313436"/>
    <dbReference type="KEGG" id="cjo:107313436"/>
    <dbReference type="CTD" id="8658"/>
    <dbReference type="GeneTree" id="ENSGT00940000156161"/>
    <dbReference type="OrthoDB" id="4772757at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097431">
        <property type="term" value="C:mitotic spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TGW7</accession>
    <name>A0A8C2TGW7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Lysine-specific demethylase 4A</fullName>
            <ecNumber evidence="4">1.14.11.66</ecNumber>
            <ecNumber evidence="22">1.14.11.69</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="24">JmjC domain-containing histone demethylation protein 3A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="26">Jumonji domain-containing protein 2A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="25">[histone H3]-trimethyl-L-lysine(36) demethylase 4A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="27">[histone H3]-trimethyl-L-lysine(9) demethylase 4A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="32" type="primary">KDM4A</name>
    </gene>
    <organism evidence="32 33">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="32" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="32" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="32" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="21">Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 2 2-oxoglutarate + 2 O2 = N(6)-methyl-L-lysyl(36)-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO2</text>
            <dbReference type="Rhea" id="RHEA:60236"/>
            <dbReference type="Rhea" id="RHEA-COMP:9786"/>
            <dbReference type="Rhea" id="RHEA-COMP:15536"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="1.14.11.69"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 2 2-oxoglutarate + 2 O2 = N(6)-methyl-L-lysyl(9)-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO2</text>
            <dbReference type="Rhea" id="RHEA:60200"/>
            <dbReference type="Rhea" id="RHEA-COMP:15538"/>
            <dbReference type="Rhea" id="RHEA-COMP:15542"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="1.14.11.66"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the JHDM3 histone demethylase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.66" evidence="4"/>
    <dbReference type="EC" id="1.14.11.69" evidence="22"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2TGW7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005016536.1">
        <property type="protein sequence ID" value="ENSCJPP00005011295.1"/>
        <property type="gene ID" value="ENSCJPG00005009503.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159643"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001650">
        <property type="term" value="C:fibrillar center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005721">
        <property type="term" value="C:pericentric heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140681">
        <property type="term" value="F:histone H3K36me2/H3K36me3 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140684">
        <property type="term" value="F:histone H3K9me2/H3K9me3 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140005">
        <property type="term" value="F:histone H4K20me2 reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014898">
        <property type="term" value="P:cardiac muscle hypertrophy in response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd15713">
        <property type="entry name" value="ePHD_JMJD2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20463">
        <property type="entry name" value="Tudor_JMJD2A_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20466">
        <property type="entry name" value="Tudor_JMJD2A_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.650:FF:000048">
        <property type="entry name" value="Lysine-specific demethylase 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000236">
        <property type="entry name" value="Lysine-specific demethylase 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000029">
        <property type="entry name" value="lysine-specific demethylase 4C isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.330.70:FF:000001">
        <property type="entry name" value="Putative lysine-specific demethylase 4a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047482">
        <property type="entry name" value="JMJD2A_ePHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003349">
        <property type="entry name" value="JmjN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040477">
        <property type="entry name" value="KDM4-like_Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047479">
        <property type="entry name" value="Tudor_KDM4A_rpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047481">
        <property type="entry name" value="Tudor_KDM4A_rpt2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694:SF119">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02375">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13831">
        <property type="entry name" value="PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18104">
        <property type="entry name" value="Tudor_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00545">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51183">
        <property type="entry name" value="JMJN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0007">Acetylation</keyword>
    <keyword evidence="11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="12" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="15" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="33" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="17" id="KW-0804">Transcription</keyword>
    <keyword evidence="16" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="JmjN" evidence="29">
        <location>
            <begin position="14"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="30">
        <location>
            <begin position="142"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="31">
        <location>
            <begin position="755"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="480"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="600"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="28">
        <location>
            <begin position="487"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="28">
        <location>
            <begin position="538"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="28">
        <location>
            <begin position="600"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00052602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00056491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00066582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00069273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00076124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00079104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00080010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00082447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS51183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="31">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005011295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1048" mass="118362" checksum="3B2535C2940169C9" modified="2022-01-19" version="1">MASELDSLNPSARIMTFRPTMEQFRDFSRYIAYVEAQGAHRAGLAKIVPPKEWKPRKCYDDIDELVIPAPIQQVVTGQSGLFTQYNIQKKAMTVREFRRIANSDKYCTPRYTDFEDLERKYWKNLTFNAPIYGADVNGTLYDKHVDAWNIGRLNTILDVVENESGITIEGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFGEPKSWYSIPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPSILKKYGIPFDKVTQEAGEFMITFPYSYHAGFNHGFNCAESTNFATLRWIEYGKQSVLCSCRKDMVKISMDVFVRKYQPDRYKLWKAGKDVTVIDHALPTPEAAEFLKGDLIIAVMCLVTWHEFVFRSVPKHRIGTKRHRVCLEVPQEVSESEAFPKEELSSVQDEADAAEPCEKSVNTYDASVPYSVFPPFATYHVGMTKSEELKAVKLEEEEEEEQEAAVLDLSISHASNSASVLPTSKQSAPSSVQPSSPAYSGSSDSESTDLLPKRTLPGPAGVLTVHSYARGDASGSDNEQTSGKKASATASVSEQELAEVTKEYIQSMKESKKAKGRRQPLSKLPRHHPLLVKDCISDDEASEQLTPEEEAEETEAWAKPLSQLWQNRPPNFEAEKEYNRTMSQQSPYCAVCMLFQTYQAECGGSSQNAEVTPGAADGKIRTKPLIPEMCFTTTGCSTDLNLSTPYLEEDGTSVLITCRNCQVCVHASCYGVSPDKATEDWMCSRCTENALEEDCCLCSLRGGALQRANDDKWVHVMCAVGVLEAKFVNIAERSPVDVGKIPLQRFRLKCIFCKKRRKRIAGCCVQCSHGRCPTSFHVSCAQAAGVMMQPDDWPFVVFITCFRHKTPSQAERAKAALQDLSPGQIVISKHKNGRFYQCEVVSLAKETFYEVNFDDGSFSDNLYPEDIVSRDCLQLGPPAEGEVVQVRWTDGQVYGAKFVASHAIQMYQVEFEDGSQLMVKRDDVYTLEEELPKRVKSRLSVASDMRFTEIFAEKEVRQERKRQRVINSRYREDYIEPALYRAIME</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TIA5</accession>
    <name>A0A8C2TIA5_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">JunD proto-onco, AP-1 transcription factor subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">JUND</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TIA5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005020322.1">
        <property type="protein sequence ID" value="ENSCJPP00005014237.1"/>
        <property type="gene ID" value="ENSCJPG00005011902.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162806"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035976">
        <property type="term" value="C:transcription factor AP-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017053">
        <property type="term" value="C:transcription repressor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001221">
        <property type="term" value="F:transcription coregulator binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071277">
        <property type="term" value="P:cellular response to calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002076">
        <property type="term" value="P:osteoblast development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045669">
        <property type="term" value="P:positive regulation of osteoblast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042127">
        <property type="term" value="P:regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050946">
        <property type="entry name" value="AP-1_TF_bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005643">
        <property type="entry name" value="JNK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11462">
        <property type="entry name" value="JUN TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11462:SF7">
        <property type="entry name" value="TRANSCRIPTION FACTOR JUND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03957">
        <property type="entry name" value="Jun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Jun-like transcription factor" evidence="6">
        <location>
            <begin position="2"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="143"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="212"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005014237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="327" mass="33149" checksum="FDA4935DBCF8C55B" modified="2022-01-19" version="1">METPFYHDDVLSGLGSGFAPTSGTGSSGSTGLLLPFPGGSMMKKDGLGLALPEQVAAALKAPGAAAAAGAAGGETAPGLLGSAELGLLKLASPELERLIIQSNGLVTTTPTSGQFLYPKAAASEEQEFAEGFVKALEDLHKQNQLGGGGGGNNGGATAAGGGGGGGGGELPAPGLAPEPPVYANLSTFPLAVTRRPGAPFWGGYWCPTVRRGDWRSPSRDPTPSSAPGPSPAPAPPQIGAPFPPPAAPPPYALSLVPPPLHTFVVPCPSAAPLRFPLPRPMPPSIPPPNSMPRAGLWRRFFTCGALWDMWRGRDCRLRPQLPRGGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TJD7</accession>
    <name>A0A8C2TJD7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lipid droplet-associated hydrolase</fullName>
            <ecNumber evidence="9">3.1.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Lipid droplet-associated serine hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LDAH</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36403"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:17002"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.13"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:36404"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lipid droplet</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AB hydrolase superfamily. LDAH family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.13" evidence="9"/>
    <dbReference type="RefSeq" id="XP_015715041.1">
        <property type="nucleotide sequence ID" value="XM_015859555.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TJD7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005019235.1">
        <property type="protein sequence ID" value="ENSCJPP00005013376.1"/>
        <property type="gene ID" value="ENSCJPG00005011295.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107312275"/>
    <dbReference type="KEGG" id="cjo:107312275"/>
    <dbReference type="CTD" id="60526"/>
    <dbReference type="GeneTree" id="ENSGT00390000009688"/>
    <dbReference type="OrthoDB" id="448051at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004771">
        <property type="term" value="F:sterol ester esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042632">
        <property type="term" value="P:cholesterol homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035356">
        <property type="term" value="P:intracellular triglyceride homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160077">
        <property type="term" value="P:lipid droplet fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019915">
        <property type="term" value="P:lipid storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000068">
        <property type="entry name" value="Lipid droplet associated hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019363">
        <property type="entry name" value="LDAH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13390">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13390:SF0">
        <property type="entry name" value="LIPID DROPLET-ASSOCIATED HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10230">
        <property type="entry name" value="LIDHydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0551">Lipid droplet</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005013376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="337" mass="38165" checksum="D8401CA5D9D0A74E" modified="2022-01-19" version="1">MLGIAEPAKGEANMRSVSEEPVPLHEEFIYCCGAATHVLKCGPWKDLSKDESKNLPRLLFMIIPGNPGLAGYYRTFIKALYCGLNQQYPVWVVSHAGHCKPPSGMEMIEDTDIKELEDVFGLNGQVEHKLNFLKKNVSKDIKLVLIAHSIGCYITLEMMKRASELQVLRSVLLFPTIERMAQSPQGKLMTPLLCKLRYALYMPVYLLSFLPEGVKASLVRFALRGMKTCDESSITTSVNLFSVDCIANILYMASQEMMKVVERDSTTIKQNLKKLIFYYGTGDSWCPQNYYDEIKMDFPDGDIRLCEKGLRHAFVLDASKEMAAMITDWLRDDLTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TJJ3</accession>
    <name>A0A8C2TJJ3_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DCN1-like protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Defective in cullin neddylation protein 1-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">DCUN1D4</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TJJ3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005018231.1">
        <property type="protein sequence ID" value="ENSCJPP00005012604.1"/>
        <property type="gene ID" value="ENSCJPG00005010713.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156935"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032182">
        <property type="term" value="F:ubiquitin-like protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000436">
        <property type="term" value="P:positive regulation of protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000041">
        <property type="entry name" value="DCN1-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.200:FF:000002">
        <property type="entry name" value="DCN1-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.200">
        <property type="entry name" value="Cullin, PONY binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DCN-prot"/>
    </dbReference>
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        <property type="entry name" value="DCN1-like_PONY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005176">
        <property type="entry name" value="PONY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281:SF8">
        <property type="entry name" value="DCN1-LIKE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281">
        <property type="entry name" value="RP42 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03556">
        <property type="entry name" value="Cullin_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51229">
        <property type="entry name" value="DCUN1"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DCUN1" evidence="5">
        <location>
            <begin position="102"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="41"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005012604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="293" mass="34017" checksum="4EACCD149672A9F0" modified="2022-01-19" version="1">MEHPEAAGGYFQLNSHLSTLANIHKIYHTLNRLNLTEDVGQDDHQTGSLRSCSSSDCFSKVMPPRKKRRPAAGDDLSAKKSRHDGMYRKYDSTRIKAEEEVFSSKRCLEWFYEYAGTDDIVGPEGMEKFCEDIGVEPENVVMLVLAWKLDAQNMGYFTLQEWLKGMTSLQCDTTEKLRNSLDCLRSLLNEPTNFKLIYRYAFDFAREKDQRSLDINTAKCMLGLLLGKTWSLFPVFHQFLEQSKYKVINKDQWCNVLEFSRTINLDLSNYDEDGAWPVLLDEFVEWYKGKQMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TKZ6</accession>
    <name>A0A8C2TKZ6_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2 calcium-dependent domain-containing protein 4C-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC107318460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015727764.1">
        <property type="nucleotide sequence ID" value="XM_015872278.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TKZ6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005021579.1">
        <property type="protein sequence ID" value="ENSCJPP00005015196.1"/>
        <property type="gene ID" value="ENSCJPG00005012617.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107318460"/>
    <dbReference type="KEGG" id="cjo:107318460"/>
    <dbReference type="GeneTree" id="ENSGT00940000162206"/>
    <dbReference type="OrthoDB" id="9947256at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043549">
        <property type="entry name" value="C2C4C/C2C4D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46291">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46291:SF8">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="316"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="256"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="431" mass="46847" checksum="503D0611D2C77622" modified="2022-01-19" version="1">MWFLDKIRVSQGSGNLPCASFLGLPSGQHLLEKARLGAAAFPNVLTPDRIPEFCIPPRLSSSAPAQGPGSRQHHGLEDARLSVSERSSSSSLPHFIQVESAEEIPALEEEGTNSDPQSQAALSLPHFPRAPTSYGFCTLLESPHTRRKESIFHGDTCGALPSLTLPRSRANTFSGKGNTSSPIAISFTSVRLPPRHLYRQGACDSDTASSSDSSPFSSPLLSRSPPKSCSLIKARSQEGLLCRALKAKNKSGMARNNSLSTEESSSTDNSPSAIRRASEGLLATRSCSVSCSPLFPLDFARGRQRLVGESTVVMDKGGMLRLSAEYCSENERLRIRLISAEGLYDDSVEPKNINCCITLSLVPGKTQKQRSTVIKRSRNPIFNEDFFFDGIAEEELLSRSVRMKATNKGCSMKRDYTLGEQELSLMSMLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TLB1</accession>
    <name>A0A8C2TLB1_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="23">Solute carrier family 12 member 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">SLC12A2</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>K(+)(out) + 2 chloride(out) + Na(+)(out) = K(+)(in) + 2 chloride(in) + Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:72395"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:72396"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC12A transporter family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015705148.1">
        <property type="nucleotide sequence ID" value="XM_015849662.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TLB1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005021796.1">
        <property type="protein sequence ID" value="ENSCJPP00005015352.1"/>
        <property type="gene ID" value="ENSCJPG00005012751.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107306466"/>
    <dbReference type="KEGG" id="cjo:107306466"/>
    <dbReference type="CTD" id="6558"/>
    <dbReference type="GeneTree" id="ENSGT00940000155742"/>
    <dbReference type="OrthoDB" id="2020542at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome Z"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009925">
        <property type="term" value="C:basal plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016328">
        <property type="term" value="C:lateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008511">
        <property type="term" value="F:sodium:potassium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006884">
        <property type="term" value="P:cell volume homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990869">
        <property type="term" value="P:cellular response to chemokine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055064">
        <property type="term" value="P:chloride ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055075">
        <property type="term" value="P:potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055078">
        <property type="term" value="P:sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010818">
        <property type="term" value="P:T cell chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070634">
        <property type="term" value="P:transepithelial ammonium transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030321">
        <property type="term" value="P:transepithelial chloride transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000005">
        <property type="entry name" value="Solute carrier family 12 member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013612">
        <property type="entry name" value="AA_permease_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002444">
        <property type="entry name" value="NKCC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018491">
        <property type="entry name" value="SLC12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002443">
        <property type="entry name" value="SLC12A1/SLC12A2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004842">
        <property type="entry name" value="SLC12A_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00930">
        <property type="entry name" value="2a30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827:SF58">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 12 MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08403">
        <property type="entry name" value="AA_permease_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03522">
        <property type="entry name" value="SLC12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01207">
        <property type="entry name" value="NAKCLTRNSPRT"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01208">
        <property type="entry name" value="NAKCLTRSPRT1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-0868">Chloride</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0915">Sodium</keyword>
    <keyword evidence="15" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="8" id="KW-0769">Symport</keyword>
    <keyword evidence="7 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="253"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="300"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="423"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="457"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="534"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="590"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="616"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="646"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="671"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease N-terminal" evidence="22">
        <location>
            <begin position="138"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="20">
        <location>
            <begin position="226"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="domain" description="SLC12A transporter C-terminal" evidence="21">
        <location>
            <begin position="736"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="901"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF03522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF08403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1152" mass="126897" checksum="536BBD3532028966" modified="2022-01-19" version="1">MEGKQQQQQQPPQREPGPGELKVPGAVGEEPRSEGKDAGADGLGRPLGPTPSQSRFQVDLVAEAPRRANGEGDVAGKGSEEAKGRFRVNFVDPSAGDESPSEPGGCSEGANVSFQNGGDTVLSEGSLHSGGHHHYYYDTHTNTYYLRTFGHNTMDAVPRIDHYRHTAADLGEKLIRPSLAELHDELDKEPFEDGYANGEEGTPAGDAAATYTPDSKGIVKFGWIKGVLVRCMLNIWGVMLFIRLSWIVGQAGIGLSVVVIAMATVVTTITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGAIGLIFAFANAVAVAMYVVGFAETVVELLKENGTLMIDEMNDIRIIGAITVVILLGISVAGMEWEAKAQIVLLVILILAIGDFVIGTFIPLDSKKAKGFFGYKAEIFMENFGPDFRNEETFFSVFAIFFPAATGILAGANISGDLADPQSAIPKGTLLAILITTLVYMGIAVSVGSCVVRDATGNINNTIITELTNCTTAACKLNYDFSSCQTECHYGLMNNFQVMSMVSGFAPLISAGIFSATLSSALASLVSAPKIFQALCKDNIYPGFQMFAKGYGKNNEPLRGYLLTFLIALGFILIAELNVIAPIISNFFLASYALINFSVFHASLAKSPGWRPAFKYYNMWISLVGAILCCIVMFVINWWAALLTYVIVLGLYIYVTYKKPDVNWGSSTQALTYLNALQHSIRLSGVEDHVKNFRPQCLIMTGPPNARPALLHLVHAFTKNVGLMICGHVHMGPRRQAMKELSTDLAKYQRWLIKNKMKAFYAPVHAEDLRDGGQYLMQAAGLGRMRPNTLVVGFKKNWRQSDMRDVETYINLFHDAFDIQYGVVVIRLKEGLDISHLQGQEELLSSQEKSPCSKDVIVKVDYSKKAETDTSVAFVPSSSERTPAPHREEDEDGKTPTQPLLKKDWRTPSSPLNVADQRLLDASSQFQKKQGKSNIDVWWLFDDGGLTLLIPYLITTKKKWKECKIRVFIGGKINRIDHDRRAMATLLSKFRIDFSDIMVLGDINTKPKKENIAAFEEMIEPFRLHEDDKEQEVADKMKEDEPWRITDNELELYKTKTYRQIRLNELLKEHSSTANVIVMSLPVARKGAVSSALYMAWLEALSKDLPPILLVRGNHQSVLTFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TLG4</accession>
    <name>A0A8C2TLG4_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Leucine rich repeat containing 49</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LRRC49</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015728067.1">
        <property type="nucleotide sequence ID" value="XM_015872581.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TLG4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005021734.1">
        <property type="protein sequence ID" value="ENSCJPP00005015314.1"/>
        <property type="gene ID" value="ENSCJPG00005012706.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107318582"/>
    <dbReference type="KEGG" id="cjo:107318582"/>
    <dbReference type="CTD" id="54839"/>
    <dbReference type="GeneTree" id="ENSGT00940000157011"/>
    <dbReference type="OrthoDB" id="1939344at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000323">
        <property type="entry name" value="Leucine-rich repeat-containing protein 49 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050576">
        <property type="entry name" value="Cilia_flagella_integrity"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973:SF8">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT SDS22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="112"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="642"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="656"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="752" mass="85668" checksum="926EDBCD74542FEC" modified="2022-01-19" version="1">MDMVPSKGRQGRGSRAAPGPAGSCGLQLLIQASAIPSKTKPFDFRINKESPSLHNRLLQHDLEKNYSGRQGDPRVLSPLVRNKQLYLPVPSTLTELSGLEFKQNAGSLSGFGESSIHAKPRSRQSSHSISSHASDNTNFGSSSSITFPVLQRTAEEKILNSDRLTLERQKLTVCPVIDGEDHLRLLNFQHNFITRIQNISNLQHLVFLDLYDNQIEEISGLSTLRSLRVLLLGKNRIKKISNLDSLKNLDVLDLHGNQITKIENINHLSELRVLNLARNLLSIVENLNGLDSLTELNLRHNQVSAIKDVDTLPRLQRLFLSFNNISSFDDILCLADSSSLSDITLDGNPIAQETWYKHTVLHHMMQLRQLDMKRITEEERRMASVAARKEEERKRESHKQSLLKEKKRLTICNIARQWEIQQNRIELEASLNQDKDNQPCPINGSAAYVFPEESRSLDTILNSAVQGLSVLESHLVELEGDTLYLYGSGALECLDRNWSVQTAGTIVTVSFVFIEFDEIVQVLTKLKIKFPNSVHLKFKETNLVTLQQFNALAQLHRMEQLTVDPQGNPVVNFTLWKYYVLFRLNHFNLQKINGIEVTQDDVVMAERLFGILAYVASSELPRYRLLSSFGESRMKQFSYLLEGKGKKPGTGNEESSDNRRAGRESSARATLNYVTKDFHMEKLEEIKERKAFCQTYVKNLVKEAADIHMKNESLQKLWPQMFIELVRDAVIEIRNKNSYMKLSLQRITDQKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TM18</accession>
    <name>A0A8C2TM18_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Methenyltetrahydrofolate cyclohydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">MTHFD2</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(6R)-5,10-methenyltetrahydrofolate + H2O = (6R)-10-formyltetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="EC" id="3.5.4.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NAD(+) = (6R)-5,10-methenyltetrahydrofolate + NADH</text>
            <dbReference type="Rhea" id="RHEA:22892"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.5.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015738478.1">
        <property type="nucleotide sequence ID" value="XM_015882992.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TM18"/>
    <dbReference type="Ensembl" id="ENSCJPT00005020384.1">
        <property type="protein sequence ID" value="ENSCJPP00005014295.1"/>
        <property type="gene ID" value="ENSCJPG00005011940.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107323669"/>
    <dbReference type="KEGG" id="cjo:107323669"/>
    <dbReference type="CTD" id="10797"/>
    <dbReference type="GeneTree" id="ENSGT00940000164825"/>
    <dbReference type="OrthoDB" id="5126881at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004487">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000001">
        <property type="entry name" value="Bifunctional protein FolD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000070">
        <property type="entry name" value="probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01576">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020867">
        <property type="entry name" value="THF_DH/CycHdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099:SF15">
        <property type="entry name" value="BIFUNCTIONAL METHYLENETETRAHYDROFOLATE DEHYDROGENASE_CYCLOHYDROLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00766">
        <property type="entry name" value="THF_DHG_CYH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00767">
        <property type="entry name" value="THF_DHG_CYH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic" evidence="13">
        <location>
            <begin position="35"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding" evidence="14">
        <location>
            <begin position="169"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00036357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00061364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005014295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="337" mass="36490" checksum="F6FB3DB1CBEC9A83" modified="2022-01-19" version="1">MAAPLCPLRTLGRVTLRPRSRRLHLSAPRDDAVVISGRKLARQIRQEARHEVEQWVAAGNKRPHLSVVLVGENPASHSYVLNKTKAAADVGISSETILKPASITEEELLDLISKLNNDANVDGLLVQLPLPEHIDERKICNAVTPDKDVDGFHVINVGRMCLDQYSMLPATPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHTDGRHERPGGDATVTISHRYTPKEQLKQHTIRADIVVAAAGIPNLITADMIKEGAAVIDVGITRVQDPITAKSRLVGDVDFEGVKKKASYITPVPGGVGPMTVAMLMKNTIIAAKKLLKPKALEALTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TP54</accession>
    <name>A0A8C2TP54_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="24">Ethanolaminephosphotransferase 1</fullName>
            <ecNumber evidence="20">2.7.8.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="25">Selenoprotein I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="primary">SELENOI</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="28" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="28" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="23">Ethanolaminephosphotransferase that catalyzes the transfer of phosphoethanolamine (PE) from CDP-ethanolamine to lipid acceptors, the final step in the synthesis of PE via the 'Kennedy' pathway. PE is the second most abundant phospholipid of membranes in mammals and is involved in various membrane-related cellular processes. The enzyme is critical for the synthesis of several PE species and also catalyzes the synthesis of plasmanyl-PE, a lipid required for proper myelination and neurodevelopment, from 1-alkyl-2-acylglycerol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>1-O-alkyl-2-acyl-sn-glycerol + CDP-ethanolamine = a 1-O-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36187"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:52595"/>
            <dbReference type="ChEBI" id="CHEBI:57876"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:60520"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:36188"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>CDP-ethanolamine + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32943"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57876"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="2.7.8.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:32944"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="19">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 26">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.1" evidence="20"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2TP54"/>
    <dbReference type="Ensembl" id="ENSCJPT00005022209.1">
        <property type="protein sequence ID" value="ENSCJPP00005015705.1"/>
        <property type="gene ID" value="ENSCJPG00005012971.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183117"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004307">
        <property type="term" value="F:ethanolaminephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008611">
        <property type="term" value="P:ether lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042552">
        <property type="term" value="P:myelination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000006">
        <property type="entry name" value="Putative ethanolaminephosphotransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014472">
        <property type="entry name" value="CHOPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414">
        <property type="entry name" value="ETHANOLAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414:SF47">
        <property type="entry name" value="ETHANOLAMINEPHOSPHOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015665">
        <property type="entry name" value="CHOPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="17" id="KW-0464">Manganese</keyword>
    <keyword evidence="15 27" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="18" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 26" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 27" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 27" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="252"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00037891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00038986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00052094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00059224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00070294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00083013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="396" mass="44963" checksum="698C71A98AB77E96" modified="2022-01-19" version="1">GDWIQGAQLAGMEHREYSAVDSNPLSVYVMHPFWNTIVKIFPTWLAPNLITFSGFLLLVFNFFLMAYFDPDFYASAPDHQHVPNGVWVVVGLLNFIAYTLDGVDGKQARRTNSSTPLGELFDHGLDSWACVYFVVTVYSTFGRGSTGVSVFVLYLLLWVVLFSFILSHWEKYNTGILFLPWGYDISQVTISIVYIVTAIVGVEAWYAPFLFNFLYRDLFTTMIIACALTVTLPMSLYNFYKAYKNNTLKHHSVYEIMLPLVSPVLLFALCTTWIFVSPMDILEVHPRLFYFMVGTAFANISCQLIVCQMSSTRCQPLNWMLLPIALQRDASPLPANCIPHLGAHPLWSDRGEPAEQALQYTTLLIKETHSGLTRNGRRENQLAVCRSTVNICCKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TQ44</accession>
    <name>A0A8C2TQ44_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Keratin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC107324382</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the avian keratin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TQ44"/>
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    </dbReference>
    <dbReference type="GeneID" id="107324382"/>
    <dbReference type="KEGG" id="cjo:107324382"/>
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        <property type="component" value="Chromosome 25"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Keratin"/>
    </dbReference>
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        <property type="entry name" value="BETA-KERATIN-RELATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31203:SF1">
        <property type="entry name" value="BETA-KERATIN-RELATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Keratin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0416">Keratin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005017209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="131" mass="13247" checksum="AD628B54B1C55A2F" modified="2022-01-19" version="1">MSCYDLCPTTNSIACPQPIANSCNEPCVRQCPDSTALIQPPPVVVTFPGPILSSFPQQAVVGSSGAPALGGSAGLGGLYGSRSSYGIGSSLGYGAQYGYGSSALSTFGSGFCSPFSSRRYSRILRGSCGPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TQE0</accession>
    <name>A0A8C2TQE0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Keratin</fullName>
        </recommendedName>
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    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the avian keratin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TQE0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005024027.1">
        <property type="protein sequence ID" value="ENSCJPP00005017203.1"/>
        <property type="gene ID" value="ENSCJPG00005014073.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234722"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
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        <property type="term" value="C:intermediate filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003461">
        <property type="entry name" value="Keratin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31203">
        <property type="entry name" value="BETA-KERATIN-RELATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31203:SF1">
        <property type="entry name" value="BETA-KERATIN-RELATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02422">
        <property type="entry name" value="Keratin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0416">Keratin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005017203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="172" mass="17782" checksum="5E6E954DE7D0A343" modified="2022-01-19" version="1">MSCEKTLCTEPCAAVGNVKGPEPCAAACSEPCVVACPDSRVIIFPPPVVVTIPGPILTTYPQETIVGSTESAELAGALESGVAIGSTQKGAECALPCSVPCAVPCAEPCATKLVTKCEAPCPPPCPPPCPPPCPPPCVPQCEPQCVPQCVPERSYTYSTQWKHPCQRGFCKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TQY9</accession>
    <name>A0A8C2TQY9_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RanBD1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TQY9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005022661.1">
        <property type="protein sequence ID" value="ENSCJPP00005016070.1"/>
        <property type="gene ID" value="ENSCJPG00005013255.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000164065"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006607">
        <property type="term" value="P:NLS-bearing protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000018">
        <property type="entry name" value="E3 SUMO-protein ligase RanBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045255">
        <property type="entry name" value="RanBP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138:SF87">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE RANBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138">
        <property type="entry name" value="RAN BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00638">
        <property type="entry name" value="Ran_BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00160">
        <property type="entry name" value="RanBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50196">
        <property type="entry name" value="RANBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RanBD1" evidence="1">
        <location>
            <begin position="25"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005016070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="204" mass="23496" checksum="E65A1FD46964A05E" modified="2022-01-19" version="1">MLITSTDFGEKDDDVYKTEDSDDIHFEPIVQMPEKVEPFTGEEDEKVLYSQRVKLFRFDPETSQWKERGVGNLKILKNEVNGKVRILMRREQVLKVCANHWITTTMNLKQLSGSDKAWMWMASDFSDGDAKLEQLAAKFKTPEQAEEFKQKFEECQKLLLDIPLQTPHKLVDTGRTAQLIQKAEEMKTGLSGLSVKAEIKVKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TRW0</accession>
    <name>A0A8C2TRW0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">5-hydroxytryptamine receptor 2C</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Serotonin receptor 2C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">HTR2C</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="14">Interacts with MPDZ. Interacts with ARRB2. Interacts with MPP3; this interaction stabilizes the receptor at the plasma membrane and prevents the desensitization of the HTR2C receptor-mediated calcium response.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015715709.1">
        <property type="nucleotide sequence ID" value="XM_015860223.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015715710.1">
        <property type="nucleotide sequence ID" value="XM_015860224.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015715711.1">
        <property type="nucleotide sequence ID" value="XM_015860225.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TRW0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005024394.1">
        <property type="protein sequence ID" value="ENSCJPP00005017512.1"/>
        <property type="gene ID" value="ENSCJPG00005014283.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005024395.1">
        <property type="protein sequence ID" value="ENSCJPP00005017513.1"/>
        <property type="gene ID" value="ENSCJPG00005014283.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005024396.1">
        <property type="protein sequence ID" value="ENSCJPP00005017514.1"/>
        <property type="gene ID" value="ENSCJPG00005014283.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107312619"/>
    <dbReference type="KEGG" id="cjo:107312619"/>
    <dbReference type="CTD" id="3358"/>
    <dbReference type="GeneTree" id="ENSGT01050000244937"/>
    <dbReference type="OrthoDB" id="420518at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098666">
        <property type="term" value="C:G protein-coupled serotonin receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071886">
        <property type="term" value="F:1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001587">
        <property type="term" value="F:Gq/11-coupled serotonin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030594">
        <property type="term" value="F:neurotransmitter receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051378">
        <property type="term" value="F:serotonin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099589">
        <property type="term" value="F:serotonin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001662">
        <property type="term" value="P:behavioral fear response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019934">
        <property type="term" value="P:cGMP-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007631">
        <property type="term" value="P:feeding behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007187">
        <property type="term" value="P:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007626">
        <property type="term" value="P:locomotory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007208">
        <property type="term" value="P:phospholipase C-activating serotonin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050850">
        <property type="term" value="P:positive regulation of calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070374">
        <property type="term" value="P:positive regulation of ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045600">
        <property type="term" value="P:positive regulation of fat cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010513">
        <property type="term" value="P:positive regulation of phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032098">
        <property type="term" value="P:regulation of appetite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043397">
        <property type="term" value="P:regulation of corticotropin-releasing hormone secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031644">
        <property type="term" value="P:regulation of nervous system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007210">
        <property type="term" value="P:serotonin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15305">
        <property type="entry name" value="7tmA_5-HT2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000377">
        <property type="entry name" value="5HT2C_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002231">
        <property type="entry name" value="5HT_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24247">
        <property type="entry name" value="5-HYDROXYTRYPTAMINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24247:SF32">
        <property type="entry name" value="5-HYDROXYTRYPTAMINE RECEPTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00517">
        <property type="entry name" value="5HT2CRECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01101">
        <property type="entry name" value="5HTRECEPTOR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0085">Behavior</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 15" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 15" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0732">Signal</keyword>
    <keyword evidence="12 15" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 15 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044679396" description="5-hydroxytryptamine receptor 2C" evidence="17">
        <location>
            <begin position="20"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="102"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="18">
        <location>
            <begin position="82"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00046825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005017512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="472" mass="52538" checksum="2A25BB4E96E99B2B" modified="2022-01-19" version="1">MSTLSSTGILLSLTTVSVTLDFSLHGGLMAWSLSTNLTLNQSLPTSDPLNASEKGEVSRMSVREKNWPALLILVIILLTIGGNILVIMAVSLEKKLQNATNFFLMSLAVADMLVGILVMPVSLIAVLYDYAWPLPKQLCPIWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAAVWTISIGISMPIPVIGLQDDSRVFINGTCVLNDENFVLIGSFMAFFIPLIIMVITYCLTVQVLQRQATVFMCGEVPKQRRSSVNCLKKENNTEHISMLHNHEGASHLNSPVSKEAVLFRKGTMQSINNERRASKVLGIVFFLFLIMWCPFFITNVMSVLCKEACDKDLLSELLDVFVWVGYVCSGVNPLVYTLFNKTYRRAFSSYIRCQYKTSKKSALRQNQCLNVASTALYGKDLTLTSYRNGNELNSMELDEAEEGLEMQPGTSELSINSCNVVSERVSCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TS89</accession>
    <name>A0A8C2TS89_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">TRIO and F-actin binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">TRIOBP</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TS89"/>
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        <property type="protein sequence ID" value="ENSCJPP00005016613.1"/>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TTB1</accession>
    <name>A0A8C2TTB1_COTJA</name>
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        <name evidence="9" type="primary">CRISPLD2</name>
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        <name type="scientific">Coturnix japonica</name>
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        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <subcellularLocation>
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        </subcellularLocation>
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        <property type="project" value="UniProtKB-SubCell"/>
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    </dbReference>
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        <property type="entry name" value="V5TPXLIKE"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034798519" evidence="7">
        <location>
            <begin position="24"/>
            <end position="503"/>
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        <location>
            <begin position="290"/>
            <end position="385"/>
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            <begin position="391"/>
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        </source>
    </evidence>
    <sequence length="503" mass="56781" checksum="127CA3E49432A33A" modified="2022-01-19" version="1">MDPALPWILPLGCVLLLANAAHCFILPNSSHLESILSKYQDGEAHSRSKRAILFSDRQEILMLHNKLRGQVYPSASNMEYMTWDDELERSAHAWAQQCIWDHGPSALIRSIGQNLAVHWGRYRSPAFHVQSWYDEVKDYSYPYPHECNPWCPDKCTGPMCTHYTQIVWATTNKIGCAVNVCKQMNVWGEIWENAVYLVCNYSPKGNWIGEAPYKNGRPCSECPPSYGGSCQNNLCYKDYRYEDPYITETDETNEVETPQLSEHKPVWLHPPENEPSKTIKPKKTTSNSYMTQVITCETKMRDKCRGSTCNRYLCPAGCLYSKGKVFGTFYYESSSSICRAAIHYGILDNKGGLVDITRKGRTPAFVKSTRNGVESFRKNKPSNAFMVSKVTTQTLDCYTTVAELCQFKKPTTHCPRIYCPAHCKDEPSYWAPVFGTNIYADSSSICKSAVHAGVIADEEGGFVDVMPVEKKKSYVGSFKNGVQSESLRSPADGNAFRIFAVKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TUV0</accession>
    <name>A0A8C2TUV0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GPI mannosyltransferase 2</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">PIGV</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the PIGV family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="RefSeq" id="XP_015738675.1">
        <property type="nucleotide sequence ID" value="XM_015883189.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032304928.1">
        <property type="nucleotide sequence ID" value="XM_032449037.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032304929.1">
        <property type="nucleotide sequence ID" value="XM_032449038.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032304930.1">
        <property type="nucleotide sequence ID" value="XM_032449039.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032304931.1">
        <property type="nucleotide sequence ID" value="XM_032449040.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032304932.1">
        <property type="nucleotide sequence ID" value="XM_032449041.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032304933.1">
        <property type="nucleotide sequence ID" value="XM_032449042.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032304934.1">
        <property type="nucleotide sequence ID" value="XM_032449043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TUV0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005026387.1">
        <property type="protein sequence ID" value="ENSCJPP00005019028.1"/>
        <property type="gene ID" value="ENSCJPG00005015460.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107323796"/>
    <dbReference type="KEGG" id="cjo:107323796"/>
    <dbReference type="CTD" id="55650"/>
    <dbReference type="GeneTree" id="ENSGT00390000013174"/>
    <dbReference type="OrthoDB" id="10252502at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031501">
        <property type="term" value="C:mannosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004376">
        <property type="term" value="F:GPI mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007315">
        <property type="entry name" value="PIG-V/Gpi18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468:SF2">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04188">
        <property type="entry name" value="Mannosyl_trans2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4 11" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="193"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="246"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="384"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="488"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005019028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="515" mass="57459" checksum="34440EC1E7E314C6" modified="2022-01-19" version="1">MELLSKQDPYLRVVVHTAVCCRVLTLLLQAVFDLLIPDHTADAFSPPRLLEPGAYDLLLEQLLGGLAHWDAEHFLFIAERGYLYEHNCAFFPLYPLSLRAVADGALWPLWQLLCLRSRLLLSAVLLNSVFSVLAAAALYKLGCAVLQCRRTAFLAALLFCISPASVFMAAAYSESMFAFLAFSAMWQLEKGQSWLSTLLFSLATGVRANGLVNAGFFLYSHSKSFALQLQVGSGSVRKLSLLWRQLLSMASSMLLTCAGICLPFALFQYYAYVRFCGPGLELAVPKPLQKLALDKGYRLVSPNGVKPPWCSQRFPVAYSYIQDVYWNVGFLRYFELRQIPNFLLALPVSLLGLWAAWTFAVANPRHCLTLGLERRKKKQGEPRAGFCCPAVFVYVVHATAMLVLGFFCMHVQVLTRFLGSSSPVLYWFSAHLLQGHETWLWKEGVDGQSAVRVRERSILGAAPGSCGKGPAEGHPLLRLLLSYRSMTAVGRCVLGYFVSYWLLGLVLHCNRLPWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TVN7</accession>
    <name>A0A8C2TVN7_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Endothelin 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">EDN2</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the endothelin/sarafotoxin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TVN7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005026451.1">
        <property type="protein sequence ID" value="ENSCJPP00005019085.1"/>
        <property type="gene ID" value="ENSCJPG00005015495.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107324061"/>
    <dbReference type="KEGG" id="cjo:107324061"/>
    <dbReference type="GeneTree" id="ENSGT00950000183053"/>
    <dbReference type="OrthoDB" id="9362154at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031708">
        <property type="term" value="F:endothelin B receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001525">
        <property type="term" value="P:angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014824">
        <property type="term" value="P:artery smooth muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048675">
        <property type="term" value="P:axon extension"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009932">
        <property type="term" value="P:cell tip growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019221">
        <property type="term" value="P:cytokine-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043542">
        <property type="term" value="P:endothelial cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0086100">
        <property type="term" value="P:endothelin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097009">
        <property type="term" value="P:energy homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042116">
        <property type="term" value="P:macrophage activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048246">
        <property type="term" value="P:macrophage chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030593">
        <property type="term" value="P:neutrophil chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050850">
        <property type="term" value="P:positive regulation of calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010460">
        <property type="term" value="P:positive regulation of heart rate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002690">
        <property type="term" value="P:positive regulation of leukocyte chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031394">
        <property type="term" value="P:positive regulation of prostaglandin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045987">
        <property type="term" value="P:positive regulation of smooth muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003100">
        <property type="term" value="P:regulation of systemic arterial blood pressure by endothelin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019229">
        <property type="term" value="P:regulation of vasoconstriction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001659">
        <property type="term" value="P:temperature homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014826">
        <property type="term" value="P:vein smooth muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020475">
        <property type="entry name" value="Endothelin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019764">
        <property type="entry name" value="Endothelin_toxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001928">
        <property type="entry name" value="Endothln-like_toxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13874">
        <property type="entry name" value="ENDOTHELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13874:SF9">
        <property type="entry name" value="ENDOTHELIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00322">
        <property type="entry name" value="Endothelin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00365">
        <property type="entry name" value="ENDOTHELIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00272">
        <property type="entry name" value="END"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00270">
        <property type="entry name" value="ENDOTHELIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0838">Vasoactive</keyword>
    <keyword evidence="5" id="KW-0839">Vasoconstrictor</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034918000" evidence="7">
        <location>
            <begin position="25"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Endothelin-like toxin" evidence="8">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="Endothelin-like toxin" evidence="8">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="152"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005019085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="179" mass="20155" checksum="1C784C9B1D254920" modified="2022-01-19" version="1">MPRHPAGAALLALAFCVLLEDGMGQPPLQSHLGSAAHLRTKRCSCNSWMDKECIYFCHLDIIWVNTPGHTAPYGLGSPPRRRKRSPGRCECSRSGDSTCASFCQEEPRYRQSLRLPTSFRTSAKAPQSSDVKPSQRSLLRALRDLAASRLQFSKQQRRAQRSAPPAVLPWKKNIWKKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TVV1</accession>
    <name>A0A8C2TVV1_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Perforin 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">PRF1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complement C6/C7/C8/C9 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TVV1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005026955.1">
        <property type="protein sequence ID" value="ENSCJPP00005019460.1"/>
        <property type="gene ID" value="ENSCJPG00005015768.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063725"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022829">
        <property type="term" value="F:wide pore channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001771">
        <property type="term" value="P:immunological synapse formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031640">
        <property type="term" value="P:killing of cells of another organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001913">
        <property type="term" value="P:T cell mediated cytotoxicity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020864">
        <property type="entry name" value="MACPF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020863">
        <property type="entry name" value="MACPF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052784">
        <property type="entry name" value="Perforin-1_pore-forming"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46096">
        <property type="entry name" value="PERFORIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46096:SF3">
        <property type="entry name" value="PERFORIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01823">
        <property type="entry name" value="MACPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00457">
        <property type="entry name" value="MACPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00279">
        <property type="entry name" value="MACPF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51412">
        <property type="entry name" value="MACPF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0204">Cytolysis</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="MACPF" evidence="11">
        <location>
            <begin position="1"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="10">
        <location>
            <begin position="333"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="484"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="511"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005019460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="584" mass="63970" checksum="BEE23D1F2C8E47FA" modified="2022-01-19" version="1">MSLTEGQVLAITKPRSRHCTVCVDRLHKGRSLLLYNGISKWRAGSKCQQRSLLATGSQSMRDLVAQTEKIAQNWKVGLGAALSPGVGVTLAMAGSHSRVAEFGMQKEQEDHYSFSSTEMRCVHYWISASHKPRPSPHFLRAVRSLPPHFTPTTAPDYADLLAAYGTHYIHSAQLGGLLRSITAIRLCRAAMMGAGTQEVADCLRAEMTANMKSVKLSAMSSACRKARSNNSAHSAFNQLFNERMVEVEGGEQHGDLLYGAPENYATWLSSLQRLPGLVASSVRPLHTLLPRQDPRQAALKAAIGHYIAWRALRANCSQQCAGRGTIGLCQCGCAANNVVNADCCSKHRGMAHVTVTVLEGSGWHGDTFTATDAYVLLYFNGHRVQTATVWNNNKPKWGAQFDLGWVILHPHQKMKVEVWDQDNGWDDDRLGVCELPVQATGRQQHNVVCFPGGGHLKFSYSAMCGPSLGGSQCSEYIPQPPKSQGGLYRLSQWPPKSGVGGPVAWPQPKEGEEEDDEESEGENFWEASGVSEDNWKMVEDEDHQNPLPGLQNPSFNPWNLSVGLKKDPDPQIPFPHYGAAPPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TWR8</accession>
    <name>A0A8C2TWR8_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transmembrane protein 121-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC107310746</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TMEM121 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015712161.1">
        <property type="nucleotide sequence ID" value="XM_015856675.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TWR8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005026364.1">
        <property type="protein sequence ID" value="ENSCJPP00005019008.1"/>
        <property type="gene ID" value="ENSCJPG00005015447.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107310746"/>
    <dbReference type="KEGG" id="cjo:107310746"/>
    <dbReference type="GeneTree" id="ENSGT00390000003866"/>
    <dbReference type="OrthoDB" id="9155717at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032776">
        <property type="entry name" value="CECR6/TMEM121"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042314">
        <property type="entry name" value="TMEM121"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31046">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31046:SF2">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14997">
        <property type="entry name" value="CECR6_TMEM121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="62"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="441"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="160"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="453"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005019008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="480" mass="51887" checksum="2F373CEB4CC1C2C3" modified="2022-01-19" version="1">MYWEAFPGERGPPSITTKRGLAPSAGTELTPARAHPPVSSLGCRSVPFRSVPFRSVPFRSVPFRSVPCRAVPPRRGPPQSPPARPGGAKRRRRRRDAAGRCRAGPGAVSGDPPPRSPEEPPEVSAAPSGSSGPPFRGSAPSAPFPGVRAPRRGSPGDAAGGRRETDAEPRRLAPAVVPAARLAARLGAAALLVASLLLPPVRPHGRRLGTCGIRGVLVPGHPQNGSPATCQQAPRVPLDCTHHEQPHPHGCLPGGAEPGLQEAGHLRHGGSGRRVLLAGAPLCGHLGWGRALYVLLVATEHMEYVRTFKKKEDLRNRLFWVIVDMLDVLDIQANLWEPQKKGLPLWAEGIMFFYCYILLLVLPCVSLCEISMQGIGIMPHRMMLYPMLSMLTVNITTIFIRGSNMLFFRDSRVSSIFMGKNMLAIGLKVCMFVQYQRHRHHAPPGPGPAPQHSCQPQPSPGMQKSRDQPACPEELAQDNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TX20</accession>
    <name>A0A8C2TX20_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sin3A associated protein 130</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">SAP130</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAP130 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TX20"/>
    <dbReference type="Ensembl" id="ENSCJPT00005027130.1">
        <property type="protein sequence ID" value="ENSCJPP00005019613.1"/>
        <property type="gene ID" value="ENSCJPG00005015652.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00440000037733"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070822">
        <property type="term" value="C:Sin3-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024137">
        <property type="entry name" value="His_deAcase_cplx_SAP130"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031963">
        <property type="entry name" value="SAP130_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13497">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT SAP130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13497:SF3">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT SAP130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16014">
        <property type="entry name" value="SAP130_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase complex subunit SAP130 C-terminal" evidence="8">
        <location>
            <begin position="656"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="25"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="310"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="575"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="646"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="850"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="310"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="600"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="646"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="693"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005019613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1079" mass="113277" checksum="24E6130511FF780F" modified="2022-01-19" version="1">AGPAGWGRGGLRAARRNGRFVCRQAAMSSQQFPRSAAPPAALSSNTTAGTAGAPFLPAASDETGRDPEAAPREQHLGPPGPAPPREEKQEPVVVRPYPQVQMLAPHHPVPPGAPVTVAAPPAHLAPAVPLSFSDGLMKPPLKPTMPSRPIAPAPPSTLSAPTKVPGQVTVTMESSIPQAPTIPVATISGQQGHPSNLHHIMATNVQMSIIRSSAPGPPLHIGASHLPRGAAAAAVMSSSKVTTVLRPASQLPNAATAQPAVQHIIHQPIQSRPPVTTSSTIPPAVVATVSATRAQSPVITTTAAHATESTLSRPTLSIQQHPPSAAISIQRPAQPRDAATRITLPSHPAIGAQKPQLHTMAQKTIFSTGTPVAAATVAPILATNTIASATTAGSVSHTQAPTSTIVTMTMPSHSSHATAVTTSNIPVAKVVPQQITHTSPRIQSDYTAERSNLIPLSSHRASPNPVAMETRNDNRQSVPVQFQYFLPTYPPSAYPLTAHTYTPITSSVSTIRQYPVSAQAPNSAITAQTGVGVASTVHLNPMQLMTVDASHARHIQGIQPAPISAQGIQPAPIGTQGIQPAPIGTQGLHPAAPIGTQGLQPAPISAQQPQADTKTSAVVLADGATIVANPISNTFNTASAATTVVQTHSQSASAPAQGSSPRPSILRKKPTTDGLAVRKSLIPPQPPEVASTRVENTMRSTSGSPRPAGAKPKPEIHVSMATPVTVSMEAVSNQGSEQPTIAVPPSSQQPPSAIPTIIAAASPTSQPAAALSTIPGAVPAAPPTSTTIVAAPAPPATMSGALSAVLGPVVPEIKIKEEVEPMDIMRPVSAVPPLTTSTVSPSLALLANNLSMPPSDLPPGASPRKKPRKQQHVISTEEGDMMETNSTDDEKSTAKSLLVKAEKRKSPPKEYIDEEGVRYVPVRPRPPITLLRHYRNPWKAAYHHFQRYSDVRVKEEKKAMLQEIASQKGVSCRAQGWKVHLCAAQLLQLTNLERDVYERLTALQEGLIPKKKAATDDDLHRINELIQGNMQRCKLVMDQINEARDSMLKVLDHKDRVLKLLNKNGTVKKVSKLKRKEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TYA6</accession>
    <name>A0A8C2TYA6_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Castor zinc finger 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">CASZ1</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="Ensembl" id="ENSCJPT00005028308.1">
        <property type="protein sequence ID" value="ENSCJPP00005020528.1"/>
        <property type="gene ID" value="ENSCJPG00005016514.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000008187"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045664">
        <property type="term" value="P:regulation of neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040373">
        <property type="entry name" value="CASZ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12451">
        <property type="entry name" value="TRANSCRIPTION FACTOR CASTOR PROTEIN MING -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12451:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN CASTOR HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="572"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="689"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="55"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="128"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="414"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="847"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="942"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1067"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1362"/>
            <end position="1396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="169"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="414"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="847"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="949"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1069"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1084"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1366"/>
            <end position="1396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005020528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1396" mass="151962" checksum="CD94FE6712C60A34" modified="2022-01-19" version="1">MPFLASFPSLLPAERTICTDATSGKPTMAAKRKGGLKLNAICAKLSRQVVFDHGGAEQARADKGPQRESSNKDLPQPGTKEPGTEFSDGLSHVQKIEEDKRREVIEKWVNGEYEEPLLGRAEGKECRGAEGAEVPPEGVYMVQPKGCSDEEDNGDEADALRGSQDGAFLDDRDSDGAASKDDAYRASREASSLRDYAATTMNEFLGMFGYDDQNMRDELARKISFDKLNAATSEATAAAASLPGEDAMSKRARFSKYEEYIRKLKAGEQLSWPMHLAKSEELGSKLGKDASSVLAQPIRLPGPDASMLTETKATILPLPSPSSSQMQGLMSRASKYDFFIQKLKTGESIRPQNGNTYKKASKYDLENVKYLHLFKPGEGSPDMGGAIAFKTGKVGRPSKYDVRNIQKLTQVKAPTPSLAPAPLASTPSSAPMAGPEQAVSLPFNTPEYLKSTFSKTDSITTGTVSTVKNGLPTDKPTVSEDVNIYQKYIARFSGSQHCGHIHCAYQYREHYHCLDPECNYQRFTSKQDVIRHYNMHKKRDNSLQHGFMRFSPLDDCSVYYHGCHLNGKSTHYHCMQVGCNKVYTSTSDVMTHENFHKKNTQLINDGFQRFRATEDCGTVECQFYGQKTTHFHCRRPGCTFTFKNKCDIEKHKSYHIKDDAYAKDGFKKFYKYEECKYEGCVYSKATNHFHCIRAGCGFTFTSTSQMTSHKRKHERRHIRSSGVLGLPASLLGPKDNEQEESSNDDLIDFSAMSSKNSSLSASPTSQQSSVSLIVPAAPSSGAELASSQVSKPANSMTPATKISGLLSQALPSNIPLALALSNSALPGAAGSFFPIIPSRVSTPLPASSTNLMTAGSSGANPTSSAPTDSSSQAISASGEPSATSSPAPVASIMERISASKGLISPMMARLAAAALKPSVALEAAGNGQAAAPGRFNPVQVKQEPAEAMGSSSATGQESLQEHSLDLSVKDHGNESNGHTVSANSSLLSSLMNKMSKTSASLGNLLNIKTEGDGSQAGAGEPTQYLGKAVKALVQEKLSEPWKMYLRRLLVDCRHVLLIFHFRTEGGAVKSNSESPFSTTTDSKASLGPSSPSATSATMASAPALDVPTPSPATVPSAPTLLAWKQLASTIPQMPQIPASVPNLATSPLATTSLENAKPQVKPGFLQFQENDPCLATDCKYANKFHFHCLFGNCKYVCKTSGKAESHCLDHINPNNNLVNVRDQFAYYSLQCLCPNQHCEFRMRGHYHCLRPGCYFVTNITTKLPWHVKKHEKAERRAANGFKYFTKREECGRLGCKYNQVNSHFHCIREGCQFSFLLKHQMTSHARKHMRRMLGKNFDRVPTQGPPSMMDTETDEYMDYTGCSPGGISSESSNMDRSCSSTPVGNESTSAGKTERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TYB4</accession>
    <name>A0A8C2TYB4_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dynein axonemal assembly factor 4</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Neuron projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Dynein axonemal particle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TYB4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005027793.1">
        <property type="protein sequence ID" value="ENSCJPP00005020130.1"/>
        <property type="gene ID" value="ENSCJPG00005016248.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000173975"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120293">
        <property type="term" value="C:dynein axonemal particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030331">
        <property type="term" value="F:nuclear estrogen receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007368">
        <property type="term" value="P:determination of left/right symmetry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003351">
        <property type="term" value="P:epithelial cilium movement involved in extracellular fluid movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007507">
        <property type="term" value="P:heart development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036159">
        <property type="term" value="P:inner dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036158">
        <property type="term" value="P:outer dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06469">
        <property type="entry name" value="p23_DYX1C1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.790:FF:000015">
        <property type="entry name" value="dynein assembly factor 4, axonemal isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037894">
        <property type="entry name" value="CS_DYX1C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052004">
        <property type="entry name" value="Dynein_assembly_factor_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46492">
        <property type="entry name" value="DYNEIN ASSEMBLY FACTOR 4, AXONEMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46492:SF1">
        <property type="entry name" value="DYNEIN AXONEMAL ASSEMBLY FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="CS" evidence="12">
        <location>
            <begin position="3"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="159"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005020130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="172" mass="19884" checksum="0C8F18A7FB762FEF" modified="2022-01-19" version="1">MPLWLREHSWRQSGTAVYLSLPVRGLRVTAANIFCTERYLKVSVPPFLFEAVLYAPIDETNSTAKIGNGIVFFTLYKKEASMWESLTVADVNKEELQHLRENAVLRAQEKAKEETEAKKVTKQEHKKYALEATMKWLQKQAEARRTISADLSELEDLKEEEKNPDWLKDKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TYN6</accession>
    <name>A0A8C2TYN6_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ral GTPase activating protein catalytic subunit alpha 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">RALGAPA2</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="Ensembl" id="ENSCJPT00005026860.1">
        <property type="protein sequence ID" value="ENSCJPP00005019386.1"/>
        <property type="gene ID" value="ENSCJPG00005015594.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183139"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032484">
        <property type="term" value="P:Ral protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060178">
        <property type="term" value="P:regulation of exocyst localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032880">
        <property type="term" value="P:regulation of protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11210:FF:000001">
        <property type="entry name" value="Ral GTPase-activating protein subunit alpha-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11210">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035974">
        <property type="entry name" value="Rap/Ran-GAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000331">
        <property type="entry name" value="Rap/Ran_GAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046859">
        <property type="entry name" value="RGPA/RALGAPB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027107">
        <property type="entry name" value="Tuberin/Ral-act_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10063:SF2">
        <property type="entry name" value="RAL GTPASE-ACTIVATING PROTEIN SUBUNIT ALPHA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10063">
        <property type="entry name" value="TUBERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20412">
        <property type="entry name" value="RALGAPB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02145">
        <property type="entry name" value="Rap_GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111347">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50085">
        <property type="entry name" value="RAPGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rap-GAP" evidence="4">
        <location>
            <begin position="1615"/>
            <end position="1823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="403"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="743"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="811"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="424"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="747"/>
            <end position="757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005019386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1878" mass="211680" checksum="EF048F11A6B00CA0" modified="2022-01-19" version="1">MFSRKGHADARKSTQKALDPKRDVLTRLKHLRALLDIVDGSDLKQFFENNYSQIFFSLTSILILRIFYRWHFRSIGKKERFKNLRCEGIRLFLLWLQALQTNCTEEQILIFACLVPGFPPVMSSRGPCTLDNVISPSNSPDAKIFPEEITPLLPAVSGEKIAEDQTCYFLQLLLKYMVIQAASLEWKNKENQDTGFKFLFTLFRKYYLPHLFPSFTKLTNLYKPVLDIPDTRPRPVYITATRNNENVYSTKIPYMAARVVFIKWLVTFFLEKKYLTAVQHTKNGGEMLPKIIQTVGVVNQDKNPELETSMTYTSEQERSHSNSSTLSDRRLSNSSLCSIEEQHRTVYEMVQRILLSTRGYVNFVNEVFRQAFLLPSSDISATRKVVKVYRKWILQEKPVFMEEPDKKENSEDAVTSLEDSSAETDGKHLSSDHSGHKRSSSWGRTYSFTSAVNRGCVLEDEDKNVKAGAQAALQVFLTNSANVFLLEPCIEVPVLLKEQVDACKAVLSIFRRMIMELSMNKKTWEQMLQILLRITEAVMQKPKENQIKDTFAQSMSGLLFRTLIVAWIRANLSVYISRELWDELLSVLSSLTDWEELINEWANIMDSLTAVLARTVYGVEMTNLPLDKLSEQKEKKQRGKGGVLEPQKTAVVGRSFSLSWKSHPEVVEPMRFRSATTSGAPGVEKARNIVRQRATAKRSQSISNCVHLYEALPATKSVPLLLHTVSSLLPGISYTSCSHRLSEVEESQQSETLSGSEATGLFVDQEQQLTRSSSTSDIADQFPSDFFQGNFDEVLIQRSSSTAELDLKGDLQQTHGSHREREKSESVSSDTSIGYNNEVEIALIPWQASEEEQEVNASTDVCVDPDAPRWLQLSPSDNANLTDSSEFLADDCSIIAGGSLIGWHPDSASVLWRRILGILGDVNNIQSPKIHAKVFGYLYELWFKLAKIRDNLAISVDNQSTPSPPVLIPPLRIFASWLFKATTLPNEYKEGKLQAYRLICAMMTRRQDVLPNSDFLVHFYFVMHLGLTSEDQDILNTVIKHCPPWFFFLGLPGFTMLIGDFITAAARVLSTDLLEAPRSEAHTILGSLVCFPNIYQEIPLLQPMSEAGEIIAGSADVKCYLINILLKNATEEPSEAARCIAICGLGIWICEELTQCTNHPQVKEAINVIGVTLKFSNKLVAQVACDVLQLLVSYWQKLQEYESSLSRKITEILVATIAFLLPSAEYSCVEADKKFIVSLLLCLLDWCMALPMKMLLEPVSAGVLEDQHASKAPLLDYIYRVLHCCVNGSSTYTQQSHYVLSLADLSSADYDPFLPLGNVTSCEPAQCHSATDLGNLLTVAEEKRRRNLELIPLTARMVMTHLVNHLSHYPLSGGPAILHSLLSENHDNSYVESSELSSEVFRSPNLQLFVFNDSTLISYLQIPAEKRKDTEPAVAPSDVRVIVRDISGKYSWDGRILYGPLEGCLPRQSAADSFVISSSSEHHFSSQKDISQVEEGEDALDKLLEKIGNTSPECLLHPQRKLNEPSPPPFGMSCDQENAITEALMRQSTQENEYILKCSSDFNMKVAHQEEPRPAEPQASFYFCRLLLNDLGMNSWDRRKSFHLLKKNSKLLRELKNLDSRQCRETHKIAVFYIAEGQEDKCSILSNARGSQAYEDFVAGLGWEVDLSTHGGFMGGLQRNGSTGQTAPYYATSTVEIIFHVSTRMPSDSDDSLTKKLRHLGNDEVHIVWSEHNRNYRRGIIPTDFGDVLIVIYPMKNHMFFIEIMKKPEVPFFGPLFDGAIVTAKLLPSLICATCINASRAVKSLIPLYQSFYEERALYLEAIIQNHKEVMTFEDFAAQVFSPSPSYSLGGTGESLHVILLFRTKKHLSSRCTPVFCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TYR8</accession>
    <name>A0A8C2TYR8_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acrosin-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Acrosin-binding protein, 60 kDa form</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Proacrosin-binding protein sp32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ACRBP</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Acrosomal protein that maintains proacrosin (pro-ACR) as an enzymatically inactive zymogen in the acrosome. Involved also in the acrosome formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Secretory vesicle</location>
            <location evidence="1">Acrosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015728625.1">
        <property type="nucleotide sequence ID" value="XM_015873139.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TYR8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005028707.1">
        <property type="protein sequence ID" value="ENSCJPP00005020848.1"/>
        <property type="gene ID" value="ENSCJPG00005016729.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107318849"/>
    <dbReference type="KEGG" id="cjo:107318849"/>
    <dbReference type="CTD" id="84519"/>
    <dbReference type="GeneTree" id="ENSGT00390000000826"/>
    <dbReference type="OrthoDB" id="9009946at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001669">
        <property type="term" value="C:acrosomal vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001675">
        <property type="term" value="P:acrosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009566">
        <property type="term" value="P:fertilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009865">
        <property type="entry name" value="Proacrosin-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21362">
        <property type="entry name" value="ACROSIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21362:SF1">
        <property type="entry name" value="ACROSIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07222">
        <property type="entry name" value="PBP_sp32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034531784" description="Acrosin-binding protein" evidence="10">
        <location>
            <begin position="19"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="128"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005020848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="500" mass="55836" checksum="1F5FB87929FC5343" modified="2022-01-19" version="1">MLRLPSLLGLLMLLASSAAPPVPPVGSPLSDGEYQLFFSSLWPTWKAQASCHLRQTFGCLSPAVLRLDEQENHGQVPEGPVCSAFPEAPWFQTFCQFAQYRCSKRKFYVKRIPCPSFIPKGLQQQPYDADFWTKDGSSPTEAAPEKRPLSPADRHLHSNVDMLLKYSYALSSQKPQMQKIPPAMPVLPRPVNDKGPAVPPTVKPVPLAPAPLQPHAWAESTWEHRLQRGVWQLISTALSLETQAGTEVPATASELGSMTSGTKESMKNMALPGSLLALKRKEAVMILCYAVLEGVCVSSVVTLAWKELEEKILGFGNSVCDSLGRRHVDLCPTCAFCSLKMEQCQSIYNLRRVHCKSGGFIAYINPQISAQHQAAGNKTSFPESSEYFGTQVYRGLRPEYWCSLIATQGCDDPRVMLWLQAEYTTFRAGDLPSKICDSGGVQHPTYCAFKSYQCLQHSLYNQRVIRRGCFTNQTYHVLSEEEGKEEVRRWHQRFLSLNEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U0B9</accession>
    <name>A0A8C2U0B9_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="22">Interleukin 1 receptor accessory protein like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">IL1RAPL1</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the interleukin-1 receptor family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_032296795.1">
        <property type="nucleotide sequence ID" value="XM_032440904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U0B9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005029465.1">
        <property type="protein sequence ID" value="ENSCJPP00005021464.1"/>
        <property type="gene ID" value="ENSCJPG00005017161.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005029466.1">
        <property type="protein sequence ID" value="ENSCJPP00005021465.1"/>
        <property type="gene ID" value="ENSCJPG00005017161.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107324825"/>
    <dbReference type="CTD" id="11141"/>
    <dbReference type="GeneTree" id="ENSGT01150000286976"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004908">
        <property type="term" value="F:interleukin-1 receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045920">
        <property type="term" value="P:negative regulation of exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099175">
        <property type="term" value="P:regulation of postsynapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905606">
        <property type="term" value="P:regulation of presynapse assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099545">
        <property type="term" value="P:trans-synaptic signaling by trans-synaptic complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000188">
        <property type="entry name" value="Interleukin-1 receptor accessory protein-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001486">
        <property type="entry name" value="Interleukin-1 receptor accessory protein-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10140:FF:000004">
        <property type="entry name" value="X-linked interleukin-1 receptor accessory protein-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015621">
        <property type="entry name" value="IL-1_rcpt_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004074">
        <property type="entry name" value="IL-1_rcpt_I/II-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041416">
        <property type="entry name" value="IL-1RAcP-like_ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11890:SF22">
        <property type="entry name" value="INTERLEUKIN-1 RECEPTOR ACCESSORY PROTEIN-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11890">
        <property type="entry name" value="INTERLEUKIN-1 RECEPTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18452">
        <property type="entry name" value="Ig_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01582">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01536">
        <property type="entry name" value="INTRLKN1R12F"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01537">
        <property type="entry name" value="INTRLKN1R1F"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="16" id="KW-0395">Inflammatory response</keyword>
    <keyword evidence="12 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="21">
        <location>
            <begin position="33"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="21">
        <location>
            <begin position="168"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="20">
        <location>
            <begin position="329"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="587"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="592"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005021465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="622" mass="71616" checksum="2EBF9564C25E0B8C" modified="2022-01-19" version="1">MWYKSSGPGDFEEPIAFDGTRMSKEEDSIWFRPTVVQDSGLYACVIRNSTYCMKVSISLTVGENDTGLCYNSKMKYFEKAELSKSKEISCPEIEDFLFPFREPEILWYKECKSRTWRSSIGFIKDTLVIREVREDDIGNYTCEVKYGIFVVRRTTELTVTAPLTDKPPKLLHPLESKLTIQETQLGGSANLTCRAFFGYSGDVSPLIYWMKGEKFIEDLDDSRVWESDIRVLKEHLGEQEVSISLILNSVEEGDLGNYSCYVENGNGRRHASILLHKRELMYTVELAGGLGAILLLLVCLVTVYKCYKIEIMLFYRNHFGAEELDGDNKDYDAYLSYTKVDPDQWNQETGEEERFALEILPDMLEKHYGYKLFIPDRDLIPTGTYIEDVARCVDQSKRLIIVMTPNYVVRRGWSIFELETRLRNMLVTGEIKVILIECSELRGVMNYQEVEALKHTIKLLTVIKWHGPKCNKLNSKFWKRLQYEMPFKRTEPITHEQVLDVSEQGPFGELQTVSAISMAAATSTALATAHPDLRSTFHNTYHSQMRQKHYYRSYEYDVPPTGTLPLTSIGNQHTYCNIPMTLINGQRPQTKTNREQNPEEAHTNSAILPLLPRETSISSVIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U109</accession>
    <name>A0A8C2U109_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Family with sequence similarity 131 member B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FAM131B</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM131 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015727961.1">
        <property type="nucleotide sequence ID" value="XM_015872475.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U109"/>
    <dbReference type="Ensembl" id="ENSCJPT00005029121.1">
        <property type="protein sequence ID" value="ENSCJPP00005021187.1"/>
        <property type="gene ID" value="ENSCJPG00005016959.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107318534"/>
    <dbReference type="CTD" id="9715"/>
    <dbReference type="GeneTree" id="ENSGT00950000183106"/>
    <dbReference type="OrthoDB" id="8899318at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026782">
        <property type="entry name" value="FAM131"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15736:SF9">
        <property type="entry name" value="PROTEIN FAM131B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15736">
        <property type="entry name" value="PROTEIN FAM131B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15010">
        <property type="entry name" value="FAM131"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="302"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="302"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="312"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="341"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="375"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005021187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="384" mass="42469" checksum="0E88145018DE5726" modified="2022-01-19" version="1">MGCIGSRTVGNEVIAVDWKGLKDVDQINMDSTSSLHGSSFHRPSTEQTRTDFSWDGINLSMEDTTSILPKLKRNSNAYGIGALAKSSFSGISRSMKDHVTKPTAMGQGRVAHMIEWQGWGKGNSQQQQHTHETARKDADAYSDLSDGEKEARFLAGVMEQFAISEATLMAWSSMDGEDVSVNSNQENPVGNYSENYQELMESQEHMAQTQYDSWPHSYVSQGMYCLGSSDAWETSDQSLIASPATGSYLGQNFDESQTNLQESILIQSSLLQQQQLQQQQQEQNFIQSTGLVHVWPLQTAQGGSGAESSTYMEDHLEDNGNPRLEKAPLLNKKPSPEEDDVVCRDLESLSPREEMEHAALSRKVSDVTSSGVQSFDEEEGETNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U375</accession>
    <name>A0A8C2U375_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Eva-1 homolog B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">EVA1B</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EVA1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2U375"/>
    <dbReference type="Ensembl" id="ENSCJPT00005029227.1">
        <property type="protein sequence ID" value="ENSCJPP00005021269.1"/>
        <property type="gene ID" value="ENSCJPG00005017024.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154096"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052461">
        <property type="entry name" value="EVA1_A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039500">
        <property type="entry name" value="EVA1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48422:SF2">
        <property type="entry name" value="PROTEIN EVA-1 HOMOLOG B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48422">
        <property type="entry name" value="PROTEIN EVA-1 HOMOLOG B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14851">
        <property type="entry name" value="FAM176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="EVA1" evidence="8">
        <location>
            <begin position="16"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="48"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="58"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005021269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="147" mass="16162" checksum="34BC86EED3AF4A59" modified="2022-01-19" version="1">GKGGKDLIPHCSNPAANPESFGLYFVLGVCFGLVLTLCLLLLRISCRPRTARPGPSDLSEDDDDDDDEDEEDTVDRAASESLLPMTEIPLECHSPGDGAAPINVFASAEELERAQRLEERERIIREIWRNGQPDLLGCGTMSRGHHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U520</accession>
    <name>A0A8C2U520_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thiamine transporter 1</fullName>
            <shortName evidence="3">ThTr-1</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Solute carrier family 19 member 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">SLC19A2</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">High-affinity transporter for the intake of thiamine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2U520"/>
    <dbReference type="Ensembl" id="ENSCJPT00005029983.1">
        <property type="protein sequence ID" value="ENSCJPP00005021884.1"/>
        <property type="gene ID" value="ENSCJPG00005017472.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183022"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015234">
        <property type="term" value="F:thiamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031923">
        <property type="term" value="P:pyridoxine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000189">
        <property type="entry name" value="thiamine transporter 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002666">
        <property type="entry name" value="Folate_carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028338">
        <property type="entry name" value="ThTr-1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00806">
        <property type="entry name" value="rfc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10686">
        <property type="entry name" value="FOLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10686:SF19">
        <property type="entry name" value="THIAMINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01770">
        <property type="entry name" value="Folate_carrier"/>
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        <property type="entry name" value="Thiamine_transporter_1"/>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="61"/>
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        <location>
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        <location>
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            <end position="137"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="149"/>
            <end position="168"/>
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    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
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        <location>
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        </location>
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        <location>
            <begin position="286"/>
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        </location>
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        <location>
            <begin position="410"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR028739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005021884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="451" mass="50631" checksum="0508D2CD4B221FE7" modified="2022-01-19" version="1">MAGPRGARPARSGPGCCWALPTALLCGYGFFCSVRPSEPFLTRYLLEPHKNLTETQVFNEIYPVWTYSYFALLVPVFLITDYVRYKPIILLQGISLIITWFLLLYAQGLRAFQLLEFFYGMVTATEVAYYAYIYSVVDVDLYRKVTSYCRSATLVGYTVGSVCGQLLVSLAGWSLFSLNVISLTSISVAFGTAWFLPMPQKSLFFHHAAAQPFSLEMKVMDCKNGQKVDALKVLKDLWQDFLQCYSSRTMLCWSVWWALSTCGYFQVINYAQGLWEMVLPSHSTEIYNGGVEAASTLLGAVAVFVVGHIKTSWAMWGEVALALFSFLIAAAVYIMDTVHNIWVCYASYVVFRIIYMLLITIATFQIATNLSVERYALVFGVNTFIALALQSLLTLIVVDASGLGLDIFTQFLIYASYFAAISLVFLGSGLYSIMRAHRRQEQVQNRSPESC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U5T3</accession>
    <name>A0A8C2U5T3_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Interleukin-12 subunit alpha</fullName>
            <shortName evidence="10">IL-12A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">IL12A</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="10">Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-12.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterodimer with IL12B; disulfide-linked. This heterodimer is known as interleukin IL-12. Heterodimer with EBI3/IL27B; not disulfide-linked. This heterodimer is known as interleukin IL-35. Interacts with NBR1; this interaction promotes IL-12 secretion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the IL-6 superfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2U5T3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005031197.1">
        <property type="protein sequence ID" value="ENSCJPP00005022751.1"/>
        <property type="gene ID" value="ENSCJPG00005018088.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000016906"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
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        <property type="term" value="C:interleukin-12 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042163">
        <property type="term" value="F:interleukin-12 beta subunit binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005143">
        <property type="term" value="F:interleukin-12 receptor binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045513">
        <property type="term" value="F:interleukin-27 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:cellular response to virus"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:defense response to Gram-positive bacterium"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:interleukin-12-mediated signaling pathway"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032700">
        <property type="term" value="P:negative regulation of interleukin-17 production"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050709">
        <property type="term" value="P:negative regulation of protein secretion"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048662">
        <property type="term" value="P:negative regulation of smooth muscle cell proliferation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900747">
        <property type="term" value="P:negative regulation of vascular endothelial growth factor signaling pathway"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000510">
        <property type="term" value="P:positive regulation of dendritic cell chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050671">
        <property type="term" value="P:positive regulation of lymphocyte proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032816">
        <property type="term" value="P:positive regulation of natural killer cell activation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002860">
        <property type="term" value="P:positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051135">
        <property type="term" value="P:positive regulation of NK T cell activation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034393">
        <property type="term" value="P:positive regulation of smooth muscle cell apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001916">
        <property type="term" value="P:positive regulation of T cell mediated cytotoxicity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032729">
        <property type="term" value="P:positive regulation of type II interferon production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032496">
        <property type="term" value="P:response to lipopolysaccharide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010224">
        <property type="term" value="P:response to UV-B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045063">
        <property type="term" value="P:T-helper 1 cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009079">
        <property type="entry name" value="4_helix_cytokine-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050676">
        <property type="entry name" value="IL-12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004281">
        <property type="entry name" value="IL-12_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48485:SF1">
        <property type="entry name" value="INTERLEUKIN-12 SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48485">
        <property type="entry name" value="INTERLEUKIN-12 SUBUNIT BETA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03039">
        <property type="entry name" value="IL12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47266">
        <property type="entry name" value="4-helical cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0202">Cytokine</keyword>
    <keyword evidence="7 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0339">Growth factor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034644152" description="Interleukin-12 subunit alpha" evidence="10">
        <location>
            <begin position="36"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005022751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="199" mass="21615" checksum="C49544CDF33A324C" modified="2022-01-19" version="1">MAEHSVSTGSRAAWLGVRHWVLLAVLCLLLPSTWALPTPAHSLAKGLNCSRALLAAANEALLRVQKQGTLGFECTLEEVDLEDVTNSQINTIKSCTSQDPRPGNCPVLESSTLDRSKCLQGIYEDLKAYKAELGNLKDLRVLTSIDDMMQVTTPQPLPSTTLGSFQARMRLCGVLHAFCLRAVTISRMLGYLSALTAET</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U677</accession>
    <name>A0A8C2U677_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Biosis of lysosomal organelles complex 1 subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BLOC1S2</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BLOC1S2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2U677"/>
    <dbReference type="Ensembl" id="ENSCJPT00005032604.1">
        <property type="protein sequence ID" value="ENSCJPP00005023862.1"/>
        <property type="gene ID" value="ENSCJPG00005018856.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000005889"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031083">
        <property type="term" value="C:BLOC-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099078">
        <property type="term" value="C:BORC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032418">
        <property type="term" value="P:lysosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019269">
        <property type="entry name" value="BLOC1_su2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46479">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46479:SF1">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10046">
        <property type="entry name" value="BLOC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005023862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="226" mass="24981" checksum="131FA52DE0747D76" modified="2022-01-19" version="1">MFNSTISVQYLKAALIKTPSSAVVTAVTPTGCQQLQQEEHLRINQNYNYYIPALSWSRMRREGAGPRPYARATAEAGGAGGRTAAMAAAAEGLSEAGAQPAKQDPAVETAEEAKEPAEADINELCKDMFSKMATYLTGELTATSEDYKLLENMNKLTSLKYLEMKDIAINISRNLKDLNQKYAALQPYLEQINLIEEQVAALEQAAYKLDAYSKKLEAKYKKLEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U697</accession>
    <name>A0A8C2U697_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sodium-dependent phosphate transport protein 2B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Na(+)-dependent phosphate cotransporter 2B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Sodium/phosphate cotransporter 2B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Solute carrier family 34 member 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">SLC34A2</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Involved in actively transporting phosphate into cells via Na(+) cotransport.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>3 Na(+)(out) + phosphate(out) = 3 Na(+)(in) + phosphate(in)</text>
            <dbReference type="Rhea" id="RHEA:71255"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:71256"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC34A transporter family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2U697"/>
    <dbReference type="Ensembl" id="ENSCJPT00005031689.1">
        <property type="protein sequence ID" value="ENSCJPP00005023114.1"/>
        <property type="gene ID" value="ENSCJPG00005018366.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183177"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005903">
        <property type="term" value="C:brush border"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031982">
        <property type="term" value="C:vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042301">
        <property type="term" value="F:phosphate ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031402">
        <property type="term" value="F:sodium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005436">
        <property type="term" value="F:sodium:phosphate symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:intracellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043627">
        <property type="term" value="P:response to estrogen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044341">
        <property type="term" value="P:sodium-dependent phosphate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003841">
        <property type="entry name" value="Na/Pi_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01013">
        <property type="entry name" value="2a58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037997">
        <property type="entry name" value="Na_Pi_symport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10010:SF23">
        <property type="entry name" value="SODIUM-DEPENDENT PHOSPHATE TRANSPORT PROTEIN 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10010">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 34 SODIUM PHOSPHATE , MEMBER 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02690">
        <property type="entry name" value="Na_Pi_cotrans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0915">Sodium</keyword>
    <keyword evidence="13" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="7" id="KW-0769">Symport</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="396"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="441"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="469"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="493"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="517"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="559"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="588"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00034042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00034091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005023114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="711" mass="77844" checksum="56E230F3D0FFE76F" modified="2022-01-19" version="1">MMKANFAQHLSIYIAGCSGCPVGPFTLLPGEKEVSQIMAPWPEVDKPETNNYIGDSSKQNQNMPGKEGENHKGNVASLGNKVEIQPAFSTIALIDETRQEEDPWALPELQDTGVKWSELDRKGKIIRVLYGIGKFIMLLCLLYLFVCSLDVLSSAFQLVGGKAAGDIFKDDSVLSNPVAGLVIGVLVTVMVQSSSTSSSIIVSMVSSTLLTVQSAIPIIMGANIGTSVTNTIVALMQAGDRNEFRRAFAGATIHDFFNWLAVFALLPIEVITGYLYHLTNVIVESFHLESGEDAPELLKVITDPFTKLIIELDKSVINAIATNDESAKNKSLVKIWCVTETNVTLQNVTLPPSENCTSPEFCWSEGNMTWTLKNISETEYITKCRHLFTETDLPDLAIGLILLALSLLVLCSCLVMIVKLLNSVLKGQVASVIKKTINTDFPFPFTWLAGYLAMLAGAGMTFVVQSSSVFTSAITPLVGIGVISIERSYPLTLGANIGTTTTAILAALASPGSTLKYSLQIALCHFFFNVSGIILFYPLPFTRLPIRMSKTLGNITAKYRWFAIFYLLICFFLLPLFVFGLSLAGWPVLLGVCLPLLALFIAVIVINIMQTRRPHSLPEKLQNWDFLPVWMHSLEPWDNMIMSSLAFCGKHCCGFCKCCKVNTEQEGAKDNQLKTMEVYENTIAMADEERGVRRAPAAACVEKTGTNNTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U7Q5</accession>
    <name>A0A8C2U7Q5_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Hypoxia-inducible factor 1-alpha inhibitor</fullName>
            <ecNumber evidence="17">1.14.11.30</ecNumber>
            <ecNumber evidence="18">1.14.11.n4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Hypoxia-inducible factor asparagine hydroxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">HIF1AN</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-asparaginyl-[ankyrin-repeat domain protein] + 2-oxoglutarate + O2 = (3S)-3-hydroxy-L-asparaginyl-[ankyrin-repeat domain protein] + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:54272"/>
            <dbReference type="Rhea" id="RHEA-COMP:13838"/>
            <dbReference type="Rhea" id="RHEA-COMP:13839"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:50347"/>
            <dbReference type="ChEBI" id="CHEBI:138107"/>
            <dbReference type="EC" id="1.14.11.n4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-asparaginyl-[hypoxia-inducible factor alpha subunit] + 2-oxoglutarate + O2 = (3S)-3-hydroxy-L-asparaginyl-[hypoxia-inducible factor alpha subunit] + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:54268"/>
            <dbReference type="Rhea" id="RHEA-COMP:13833"/>
            <dbReference type="Rhea" id="RHEA-COMP:13834"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:50347"/>
            <dbReference type="ChEBI" id="CHEBI:138107"/>
            <dbReference type="EC" id="1.14.11.30"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-aspartyl-[ankyrin-repeat domain protein] + 2-oxoglutarate + O2 = (3S)-3-hydroxy-L-aspartyl-[ankyrin-repeat domain protein] + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:54280"/>
            <dbReference type="Rhea" id="RHEA-COMP:13843"/>
            <dbReference type="Rhea" id="RHEA-COMP:13844"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29961"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:138111"/>
            <dbReference type="EC" id="1.14.11.n4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-histidyl-[ankyrin-repeat domain protein] + 2-oxoglutarate + O2 = (3S)-3-hydroxy-L-histidyl-[ankyrin-repeat domain protein] + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:54264"/>
            <dbReference type="Rhea" id="RHEA-COMP:13836"/>
            <dbReference type="Rhea" id="RHEA-COMP:13837"/>
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            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
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            <dbReference type="ChEBI" id="CHEBI:138021"/>
            <dbReference type="EC" id="1.14.11.n4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
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    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Perinuclear region</location>
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        <subcellularLocation>
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    </comment>
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    <sequence length="345" mass="39739" checksum="091AC4389F6A0467" modified="2022-01-19" version="1">MAAASSSSSSSSCCRDGPAGPGWSESQFRHYSFETRPIPRLSHSDPRAEELIENEEPVVLTDTNLVYPALKWDLDYLQENIGNGDFSVYSASTHKFLYYDEKKMANFKNFKPKSSREEMKFAEFVDRLQEIQQKGSAERLYLQQTLNDTVGRKIVVDFLGFNWNWINKQQGKRGWGQLTSNLLLIGMEGNVTPAHYDEQQNFFAQIKGYKRCILFPPDQFECLYPYPVHHPCDRQSQVDFDSPDYEKFPNFRSVVGYETVVGPGDVLYIPMYWWHHIESLLNGGITITVNFWYKGAPTPKRIEYPLKAHQKVAIMRNIEKMLGEALGSPQEVGPLLNMMIKGRYD</sequence>
</entry>
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    <accession>A0A8C2U7Y6</accession>
    <name>A0A8C2U7Y6_COTJA</name>
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        <submittedName>
            <fullName evidence="7">Sciellin</fullName>
        </submittedName>
    </protein>
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        <name evidence="7" type="primary">SCEL</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
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            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
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        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
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        <property type="project" value="UniProtKB-KW"/>
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    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="380" mass="42984" checksum="A32AA9C00FF0B2BA" modified="2022-01-19" version="1">MSAFSIRKQSPNQDNKSPSVAMKSRQQANHDVNKRRTLLQDNSWIKKRPEEESADENYGRAVLNQYKSQDSLHSSANEKEDQKTVLGRYRSDTNLDRIPGGNDIDKINKPLTLNNKQNNRQSWTPNASSANTPVTSPIKKKRQSWMPPPVSSNKTVTETVELKRATSSENLNDPTSDAFSSEQVTPQKSKTYIDDQATASNQELNDPIKVNPQSFTSNKEDKDLGDHMEVKSPDDQSKEVKSPDDQSKKGITKQIYENPPSAPNNVPEATYLSDSRRKSRNSSHHAYDENITGNTIQTVYSTSDQSIIGKDICTYCRKPLGTDAKMILDALQICCHSTCFKCEVCKRPLEDLKAGDSVWIYRQTVHCEPCYTKIKEKWIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U858</accession>
    <name>A0A8C2U858_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">SMC4</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC4 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015727558.1">
        <property type="nucleotide sequence ID" value="XM_015872072.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015727559.1">
        <property type="nucleotide sequence ID" value="XM_015872073.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015727560.1">
        <property type="nucleotide sequence ID" value="XM_015872074.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005031178.1">
        <property type="protein sequence ID" value="ENSCJPP00005022734.1"/>
        <property type="gene ID" value="ENSCJPG00005018081.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107318356"/>
    <dbReference type="KEGG" id="cjo:107318356"/>
    <dbReference type="CTD" id="10051"/>
    <dbReference type="GeneTree" id="ENSGT00900000141094"/>
    <dbReference type="OrthoDB" id="5575062at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051383">
        <property type="term" value="P:kinetochore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010032">
        <property type="term" value="P:meiotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045132">
        <property type="term" value="P:meiotic chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905821">
        <property type="term" value="P:positive regulation of chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051984">
        <property type="term" value="P:positive regulation of chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905820">
        <property type="term" value="P:positive regulation of chromosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1060.20:FF:000003">
        <property type="entry name" value="Structural maintenance of chromosomes 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1620:FF:000003">
        <property type="entry name" value="Structural maintenance of chromosomes 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000481">
        <property type="entry name" value="Structural maintenance of chromosomes 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000585">
        <property type="entry name" value="Structural maintenance of chromosomes 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937:SF172">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="16">
        <location>
            <begin position="610"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="324"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="853"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005022734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1300" mass="148459" checksum="6E590F5F377865A5" modified="2022-01-19" version="1">MASRSTKNSTAAQQKGRQHVEEHNGDMQVDKQDDGHPGEGAAEEVSNEESDNRSLEEILGSIPPPPPPAMTNEAGAPRLMITHIVNQNFKSYAGQQTLGPFHKRFSCIIGPNGSGKSNVIDAMLFVFGYRAQKIRSKKLSVLIHKSEEHMDIQSCSVEIHFQKIIDKEGDDYEVIPNSNFCVSRTAFRDNSSVYHINGKKSTFKDVGILLRSHGIDLDHNRFLILQGEVEQIAMMKPKGQTEHDEGMLEYLEDLIGSARLRDPIQTLCRRVETLNEQRGEKLNRVKMVEKEKDALEGDKNKAIEFLSLENKMFKEKNHICQYYIYDLQKRINDLEAQKENIQKETKDINEKSSKLAEEMKSKSKALKDLEKKIDKITVSIEDNKKKFTQLDLQDVEVREKLKHAKSRAKKLEKQLQKDKEKVEELKSIPTNNEKTISDATSKKELLEKAKDKEEEKLKQIMSSLKEETREIQKEKEGKEKELMEFCKTVNDARSKMDVAQAELDIYLTRYNSAVSQLNQAKEALMNTSETIKQRKAAIKDIEVKLPAAELELKEKEKKLEKLKEEELSTQDLVRNLRQKVEEAKSSLAQHRSRGKVLEALLEQKRSGSIPGIHGRLGDLGAIDEKYDVAVSSSCAALDYIVVDTIDIAQECVEFLKKTGIGSATFIALDKMDVWKKHLAKIPTPENVPRLIDLVKVEDKTFSPAFYFALRDTLVVKNLDDATRVAFQRDKRWRVVTLKGEVIEQSGTMTGGGTKVMKGRMGSSVAIDVSPEEIDKLESELQRDSKRAVQCGEEKLQLEEDITKLQKDVWEMRSTLEKYTATIQSFSEQEIRQKGQVKELEANVTAAAPDKNKQKEMEEVLSSYKKDYERVSEQAGKMESEVKRLHNLIIDFNNRKLKTQQDKVDKINQEIDDCTSTITKAQVAIKTAHRNLKKSEDSVLRTEKEIGDNEKEIKDLTEELTVLEHKATEVLNDSKQAEEALPAIQEEHRSLLKELRAIQDDEHELQKEALNVKFKIEQIDSHISTHQSKVKYWQKEISKLSLHPIEDKPPEELPVLSQEELEAIKDPDSITNQIALLEAQCHEMKPNLGAIEEYRRKEELYLKRVAELDDITNERDRFRQAYEDLRKQRLNEFMAGFNVITNKLKENYQMLTLGGDAELELVDSLDPFSEGIMFSVRPPKKSWKKIFNLSGGEKTLSSLALVFALHHYKPTPLYFMDEIDAALDFKNVSIVAFYIYEQTKNAQFIIISLRNNMFEIADRLIGIYKTNNTTKSVATNPKVIAAKGLAELGIAEHSVAQDRNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U900</accession>
    <name>A0A8C2U900_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">High mobility group protein 2-like 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">HMGXB4</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Negatively regulates Wnt/beta-catenin signaling during development.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2U900"/>
    <dbReference type="Ensembl" id="ENSCJPT00005031347.1">
        <property type="protein sequence ID" value="ENSCJPP00005022875.1"/>
        <property type="gene ID" value="ENSCJPG00005018179.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000012436"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016589">
        <property type="term" value="C:NURF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21982">
        <property type="entry name" value="HMG-box_HMGXB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000030">
        <property type="entry name" value="HMG domain-containing protein 4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025228">
        <property type="entry name" value="DUF4171"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042477">
        <property type="entry name" value="HMGXB4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048016">
        <property type="entry name" value="HMGXB4_HMG-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46584">
        <property type="entry name" value="HMG DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46584:SF1">
        <property type="entry name" value="HMG DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13775">
        <property type="entry name" value="DUF4171"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00886">
        <property type="entry name" value="HIGHMOBLTY12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
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    </dbReference>
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        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="domain" description="HMG box" evidence="8">
        <location>
            <begin position="383"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="6">
        <location>
            <begin position="383"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="55"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="442"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="215"/>
            <end position="231"/>
        </location>
    </feature>
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        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="300"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
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            <begin position="343"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="479"/>
            <end position="489"/>
        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00022687"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023125"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023242"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00058884"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00076207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005022875.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
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    </evidence>
    <sequence length="577" mass="63911" checksum="6B16C66A75617913" modified="2022-01-19" version="1">MAYDDSKKKEEFLESDRSADDIRAHREKKRYYRDLVQEEERITTQVRKSVEKTLKDSELFLGTEHHRKKRKHSSDEFCSRGLSSLDLPSKKKKKAVSSPSSTDKNMDLLKAIATPLSTSSKSSKKTSEKSSYSSSGHSESRKEHHKKKMSGSSAEHSVDDGSFHKTKKMKPLYVNTETLTLREPDGLKMKLILSPKEKSSATDDDSFSKKSSKKSSRDEQGSFHPGHELHGFLKSSRKKHKPPDSHPPSESFGADTSVFSEGHGSEYEISGVEAPPESGSSSGGELEAGELVIDDSYREIKKKKKSKKSKKKKDKERHREKRHSKSKKSSGHSSVAATEITVSPPPPSSTPYVLPPPHPAVFHSDGQNEKRRKKEEKEKEKPKKKNMSAYQVFCKEYRTNIVSEHPGIDFGDLSKKLAEVWKQLPDKDKLIWKQKAQYLQHKQNKAEATTVKRKASSSDGAPKIKASPPGAISPHKKSPTSTVVLPSSPGKAPETEPIDVAAHLQLLGESLSLIGHRLQETEGMVAVSGSLSVLLDSILCALGPLACLTTQLPELNGCPKHVLSNTLDNIAYIMPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UA53</accession>
    <name>A0A8C2UA53_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="25">VPS10 domain-containing receptor SorCS2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="29" type="primary">SORCS2</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="29" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="29" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Dendrite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cell projection</location>
            <location evidence="6">Dendritic spine</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasmic vesicle membrane</location>
            <topology evidence="4">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Early endosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Perikaryon</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="24">Postsynaptic density membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Recycling endosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="23">Synapse</location>
            <location evidence="23">Synaptosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the VPS10-related sortilin family. SORCS subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2UA53"/>
    <dbReference type="Ensembl" id="ENSCJPT00005032026.1">
        <property type="protein sequence ID" value="ENSCJPP00005023369.1"/>
        <property type="gene ID" value="ENSCJPG00005018548.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234563"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043197">
        <property type="term" value="C:dendritic spine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043204">
        <property type="term" value="C:perikaryon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098839">
        <property type="term" value="C:postsynaptic density membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060292">
        <property type="term" value="P:long-term synaptic depression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000083">
        <property type="entry name" value="Sortilin-related VPS10 domain containing receptor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.270:FF:000003">
        <property type="entry name" value="Sortilin-related VPS10 domain containing receptor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.70.80:FF:000001">
        <property type="entry name" value="Sortilin-related VPS10 domain-containing receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001399">
        <property type="entry name" value="Sortilin-related VPS10 domain-containing receptor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031777">
        <property type="entry name" value="Sortilin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031778">
        <property type="entry name" value="Sortilin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006581">
        <property type="entry name" value="VPS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050310">
        <property type="entry name" value="VPS10-sortilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106">
        <property type="entry name" value="SORTILIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106:SF9">
        <property type="entry name" value="VPS10 DOMAIN-CONTAINING RECEPTOR SORCS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18911">
        <property type="entry name" value="PKD_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15902">
        <property type="entry name" value="Sortilin-Vps10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15901">
        <property type="entry name" value="Sortilin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00602">
        <property type="entry name" value="VPS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110296">
        <property type="entry name" value="Oligoxyloglucan reducing end-specific cellobiohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="PKD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="21" id="KW-0966">Cell projection</keyword>
    <keyword evidence="22" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0967">Endosome</keyword>
    <keyword evidence="19" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="17 27" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="16" id="KW-0770">Synapse</keyword>
    <keyword evidence="10" id="KW-0771">Synaptosome</keyword>
    <keyword evidence="11 27" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 27" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="1145"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="28">
        <location>
            <begin position="882"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="31"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="147"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="26">
        <location>
            <begin position="60"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="26">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="26">
        <location>
            <begin position="172"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00004565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00010818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022599"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00034102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00034112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00074088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005023369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1275" mass="141439" checksum="EA15633FAAFB0E2C" modified="2022-01-19" version="1">MRDLGCDLVVACPAVCNPIYNVMCNVTCDPHSDPQSNSRYDPPRPGAARSDPRRAAFRCGPADGGAAPAGRSAPRTPLPREPRSGYNPPPPPPSAAVSPCPPPPRLSLPRRRATMAHAGPRVSPAAARLPLLLLLLPLLGAAAAPRCAEPCGRPSPGAVTRGARSLPEARRGGGGAAAAAAGGGRSRRASPAAGRERVSLLSTSFVLKGDASHNQAMVHWTGENSSVILILTKYYHTDMGKVLESSLWRSSDFGTLYTKLNLQPGIATVIDNFYICPTNKKKIILVSSSHNDRDQSLFISTDEGATFQKQPITFFVETLLFHPKEEDKVLAYTKEGKVYVSIDLGKKWVLLQEHVSKDHIFWAVAGVDGDPDLVHMEIQDPSGGYRYITCQIQNCSDKTMTVQFAGSTDRDSLTVQDDYIFLQTTSANRTKYYVSYRRNGFVQMKLPKYALPKDLQIISTDENQVFVAVQEWYQTDTYNLYQSDPQGVYYSILLENVRSTKQPEENVLIDILEVRGVKGVFLANQKIDGKVTTLITYNKGRDWDFLNPPDIDMNGKPTNCKPPDCYLHLHLRWADNPYVSGTVHTKDTAPGLIMGAGNLGSQLVEYKEEMYITSDCGKTWRQVFEEEHHILYLDHGGVIVAIKDTSIPLKILKFSIDEGQTWSTHNFTSTSVFVDGLLSEPGDETLVMTVFGHISYRSDWELVKVDFRPSFSRECTDDDYESWELTNLQGDRCIMGQQRSFRKRKISSWCIKGKSFTSALTSKICECANSDFLCDYGFERSAPLKSQSSKCFADFWFNPEAPPEDCVLGQAYTSSSGYRKVVSNVCEGGVDLQQNLAQHLCPLIAPKGLQISIRGESLAVKPGEDITFIVRQEQGDILNTKYQVDLGDGFKAIYVNLTMTGEPIRHRYENPGIYRVSVKAENVAGHDESVVFVQVNSPLQALNLEVVPVIGRNQEVNLTAIILPKNPNLTVFYWWIGNNLQPLLTLDSFLVTRFTVTGDVRVTVQASCGNSMLQDSKVVHVFDHFHILPLKFTKHLDMYNPDIPEWREDIGRVVTRLLAKETNIPEETLMTVVKPGLPTTADLHVLLSVNQPKRKRSVTSDKRIAAIKQALNAHNISFFLRGGYWVLVTLADSDSDSQRIGGGSGYWAIVVLFVICLVAVGAFILYKFKRKLPGRNVYAQMHNEKEQEMTSPVNHSEDTQNIIQGEEFIDDDLDSQTLGNARVTPSGRSGNLNSYRVPLLLMPVSVQSQVSGMLNGRLRCHSPPSPAPLETTTPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UAU0</accession>
    <name>A0A8C2UAU0_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MutL homolog 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MLH3</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSCJPT00005033294.1">
        <property type="protein sequence ID" value="ENSCJPP00005024427.1"/>
        <property type="gene ID" value="ENSCJPG00005019245.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00800000124176"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005712">
        <property type="term" value="C:chiasma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001673">
        <property type="term" value="C:male germ cell nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032300">
        <property type="term" value="C:mismatch repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000795">
        <property type="term" value="C:synaptonemal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019237">
        <property type="term" value="F:centromeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007144">
        <property type="term" value="P:female meiosis I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007140">
        <property type="term" value="P:male meiotic nuclear division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007130">
        <property type="term" value="P:synaptonemal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd03486">
        <property type="entry name" value="MutL_Trans_MLH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.100:FF:000003">
        <property type="entry name" value="DNA mismatch repair protein Mlh3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000028">
        <property type="entry name" value="DNA mismatch repair protein Mlh3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000031">
        <property type="entry name" value="DNA mismatch repair protein Mlh3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1540.20:FF:000005">
        <property type="entry name" value="MutL homolog 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="entry name" value="MutL, C-terminal domain, dimerisation subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.100">
        <property type="entry name" value="MutL, C-terminal domain, regulatory subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="MutL/Mlh/PMS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042121">
        <property type="entry name" value="MutL_C_regsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF47">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08676">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="DNA mismatch repair protein MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="5">
        <location>
            <begin position="211"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="MutL C-terminal dimerisation" evidence="4">
        <location>
            <begin position="1188"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="418"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="548"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="688"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="866"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="421"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="454"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="469"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="584"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="866"/>
            <end position="886"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005024427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1486" mass="165090" checksum="C9B5D0F904ABD551" modified="2022-01-19" version="1">MIKHLAEDVQARLRSGVTVTSLGQCVEELVLNSIDAKATCVAVRVDLEAFKIQVVDNGCGMGREDLCKMGKRYFTSKCSSVADLEKLSFYGFRGEALASIANMASVVEVSSKSSKTAKTFVKLFHNGNALEVCEAELNRPSGGTTVTVCNLFHQLPVRRRCMDPVLEFERVRQKVEAISLMHPSVSLSLRNDVSCSMVLQLPKTRDIHSRFCQIFGLSRSQKLREIKHKSGGFEISGYISSEGHYNKNMQFLYVNRRLVLKTRLHKLIDFLLRKESVICKAKSAPVSRQGSSSPGRPRCGPELYGIFVLNVTCAYSDYDVTLEPAKTLIEFQNWDALLACVEEGVKRFLKREHLFVEPCCEDIKEFNEDNNFCLDNAPVTKSILPEDKSIQENFKKACDEIIDSYEVFKLQSKDVKRKSTVGKNSSDPPESNKNTQDTEISSNQKIAELVGQRRNKEAEIPLPKKDDTASNFTVSDMSEQEPKGTNSSQEACDTHLRSSENLRSSFTEGCRSEIIKISNYDLRGCAENRAEDVGKQQDQVVQKSSTVGVSNNGFTRWPSEREDPSETAGESETVYGNSLIRPHNVREGDRERSEVVDNAGRGAVSSVPEKVHSHLGLKIRVMQNEPPREHKQTETNLALNMHCRAGPVSAKHTQAYSHNVSLPVQALNAKYISINVNKEYIPFCSREVGSADGNERSENKSLPSQARDGRDTSTATSKRHYEISHVSDLPLATSSGISHSKAAESPRRQIAAPRSQPCKKLSLATQLGSLEKFRRYYGRVKCTLPTPSPEQSEFHLPVSNAQANCDFSRSQNNSRGHLSICETPTLDSNNNSHVLRSSDEVLLCSGETPLDKRTLCRSPLTLSDYSEVSKQTTSSQRSPGSLSSKLCQMKSDHRAVQQLGEQLQTDSSRKDNHSFDLESSNNDLLYNPCQRYKASVEEMREGHSISKGDVCPPSDDLRAESMKCPVSLSPLSSTEGECTVSASSVLPAKNDGAEVICEDESMLNESSKQSVKDADVHCVVSPSNLAFSADNGNVGDPRDDLRSSDWLQDFDALLGKTVYINKATGLSTYNTPPEEFPAACITDLTTMAVNVVSENGFQCRCHPFRSEILLPFLPRPGKEKTLASQDQRGGDGGSLQTMLSEWDNPVFVRCPEVAVDVTSGQAENLAVKIHNILYPYRFTKDMVQSMQVLQQVDNKFIACVINTRNEMDKKKGGNLLVLVDQHAAHERIRLEQLIADSYEKEAAACGKKKLLSSSVSPPLEIEVTEEQRRILRCCYKNLKDLGLELSFPETNSSLILVKKVPLCFTEREANELRRKRQAVTKSIVEELIQEQVELVQTAGGARGTLPLTFLKVLASQACHGAIKFNDSLSPEESCRLMEALSSCQLPFQCAHGRPSMMPLADIDHLQQEIQPKPNLARLRKMVRAWQLFGNKDFNQKRCSADSLSPDTRTRVTTRPGPYLTERCTLCHNDLELAFAGSFLQEGLNSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UCJ9</accession>
    <name>A0A8C2UCJ9_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Multiple C2 and transmembrane domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">MCTP2</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Might play a role in the development of cardiac outflow tract.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MCTP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015728630.1">
        <property type="nucleotide sequence ID" value="XM_015873144.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015728631.1">
        <property type="nucleotide sequence ID" value="XM_015873145.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015728632.1">
        <property type="nucleotide sequence ID" value="XM_015873146.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032302760.1">
        <property type="nucleotide sequence ID" value="XM_032446869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UCJ9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005035885.1">
        <property type="protein sequence ID" value="ENSCJPP00005026504.1"/>
        <property type="gene ID" value="ENSCJPG00005020603.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107318856"/>
    <dbReference type="KEGG" id="cjo:107318856"/>
    <dbReference type="CTD" id="55784"/>
    <dbReference type="GeneTree" id="ENSGT00940000156291"/>
    <dbReference type="OrthoDB" id="5973539at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046928">
        <property type="term" value="P:regulation of neurotransmitter secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04042">
        <property type="entry name" value="C2A_MCTP_PRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08376">
        <property type="entry name" value="C2B_MCTP_PRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08377">
        <property type="entry name" value="C2C_MCTP_PRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000019">
        <property type="entry name" value="Multiple C2 and transmembrane domain-containing protein 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000076">
        <property type="entry name" value="multiple C2 and transmembrane domain-containing protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000088">
        <property type="entry name" value="multiple C2 and transmembrane domain-containing protein 2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013583">
        <property type="entry name" value="MCTP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45911">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45911:SF2">
        <property type="entry name" value="MULTIPLE C2 AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08372">
        <property type="entry name" value="PRT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="705"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="807"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="15">
        <location>
            <begin position="191"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="15">
        <location>
            <begin position="354"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="15">
        <location>
            <begin position="500"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="81"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00053791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00074930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005026504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="892" mass="101683" checksum="9F6E35D7167ED03B" modified="2022-01-19" version="1">MLLRTRGTAEVPCAAMDLEKSSVWGSLKQRTRPFLQNLSVRKTKKRSSKVVVSKVRSLDRRLSVSVPDMLEVETLTEEETTYSSTQVLSSGCPSGAPRSMSMKRRNSSMRPEGEDWPWLQPACTEPAVTHLDARMADSPVSEGKRPSGDDLLELLQRAHLSTELTNEMMEECGRMSLDSSVSSQMFDDGMGAEEGSDCLSHLPSPFAYLLTIHLKEGRNLVIRDRCGTSDPYVKFKLNGKTLYKSKVVQKNLNPVWDETVVLPIQTLDQKLWVKVYDRDLTSSDFMGSAFVALTELELNRTTEQVLKLEDPNSLEDDMGVIVLNLSLAVKQGDFKRNRWSSRKKRSSSKSSFMRSMRLSDSLRKNQLWNGQVTITLLEGRNIPLGGLAEVFILLKLGDQRYKSKTLCKSANPQWREQFDFHYFSDRKDMLDIEVWRKDNKKHEELLGTCKVDISALSMKQTNYLELPLEKHPGSLIMLIAVTPCTGVSISDLCVCPLGDPSERKQIAQRYSIKNSFRDMKDVGFLQVKVLKAVDLLAADFAGKSDPFCVLELGNDSLQTHTVYKNLNPEWNKVFTFPIKDIHDVLEVTVFDEDGDKPPDFLGKVAIPLLSIRNGKQSCYMLKNKDLERASKGVIYLELDVLFNPIKATIRTFKPREKRFTEENRKFSKKILSRNVDRVKKITMAIWNTIQFLRSCFLWESTVKSVIAFVVFVVTVWSFELYMVPLALLVLFAYNFSLIRTGKVNNTQDAQELMGLDEDDDEEDKESEKKGIIDRIHMVQEIIITVQSILEEIASFGERIKNTLNWTVPFLSILACLFLIAATLILYFIPLRYIILIWGINKFTKKLRNPYAIDNNELLDFLSRVPSDVQKVQHAELKPYSSSSPIRKKRSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UCY1</accession>
    <name>A0A8C2UCY1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rho GTPase-activating protein 26</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Rho-type GTPase-activating protein 26</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">ARHGAP26</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Focal adhesion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endosome membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015730962.1">
        <property type="nucleotide sequence ID" value="XM_015875476.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UCY1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005036442.1">
        <property type="protein sequence ID" value="ENSCJPP00005026906.1"/>
        <property type="gene ID" value="ENSCJPG00005020896.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107320037"/>
    <dbReference type="KEGG" id="cjo:107320037"/>
    <dbReference type="CTD" id="23092"/>
    <dbReference type="GeneTree" id="ENSGT00940000157254"/>
    <dbReference type="OrthoDB" id="3183924at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01249">
        <property type="entry name" value="BAR-PH_GRAF_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07636">
        <property type="entry name" value="BAR_GRAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04374">
        <property type="entry name" value="RhoGAP_Graf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12064">
        <property type="entry name" value="SH3_GRAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000006">
        <property type="entry name" value="Rho GTPase activating protein 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000116">
        <property type="entry name" value="Rho GTPase activating protein 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000001">
        <property type="entry name" value="Rho GTPase-activating protein 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000055">
        <property type="entry name" value="rho GTPase-activating protein 26 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035483">
        <property type="entry name" value="GRAF_BAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047234">
        <property type="entry name" value="GRAF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035481">
        <property type="entry name" value="GRAF_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047225">
        <property type="entry name" value="PH_GRAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12552">
        <property type="entry name" value="OLIGOPHRENIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12552:SF4">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16746">
        <property type="entry name" value="BAR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0965">Cell junction</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="PH" evidence="16">
        <location>
            <begin position="265"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="17">
        <location>
            <begin position="383"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="15">
        <location>
            <begin position="702"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="583"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="658"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="605"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="674"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005026906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="760" mass="86697" checksum="198113921DAB6CBA" modified="2022-01-19" version="1">MGLPALEFSECCLDSPQFRERLRSHEAELEKTNKFIKELIKDGKSLIAALKNLSSAKRKFADSLNEFKFRCIGDAETDDEICIAKSLQEFATVLRNLEDERMRMIENASEVLITPLEKFRKEQIGAAKDAKKKYDKETEKYCGVLEKHLNLSSKKKESQLQEADSQVDLVRQHFYEVSLEYVFKVQEVQERKMFEFVEPLLAFLQGLFTFYHHGYELAKDFSDFKTELTISIQNTRNRFEGTRSEVESLMKKMKENPHEHKNISPYTMEGYLYVQEKRHFGTSWVKHYCTYQRESKRITMVPFDQKSGGKGGEDEAVILKSCTRRKTDSIEKRFCFDVEAVDRPGVITMQALSEEDRRLWMEAMDGREPVYNSNKDNQSEGTAQLDNIGFSIIKKCIHAVETRGINEQGLYRIVGVNSRVQKLLSILMDPKTATETETEICAEWEIKTITSALKTYLRMLPGPLMMYQFQRSFIKAAKLENQESRVSEIHSLVHRLPEKNRQMLHLLMNHLAKVADNHKQNLMTVANLGVVFGPTLLRPQEETVAAIMDIKFQNIVIEILIENHEKIFNTVPETLPSNSQLLLSRKKSTDSKPPSCSERPLTLFHTAQPNEKQENRNSIINSSLESVISSNMNSFLNSNSAPQSNLNTSDLELEVIKPNRPNSLPQNPSPTSPLSPSWPMFSAPSSPMPTSSTSSDSSPISSPLRRARALYACKAEHDSELSFTAGTVFDNVHPSQEPGWLEGTLNGKTGLIPENYVEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UDA7</accession>
    <name>A0A8C2UDA7_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Extended synaptotagmin 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">ESYT3</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the extended synaptotagmin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2UDA7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005036677.1">
        <property type="protein sequence ID" value="ENSCJPP00005027074.1"/>
        <property type="gene ID" value="ENSCJPG00005021031.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161072"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140268">
        <property type="term" value="C:endoplasmic reticulum-plasma membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031210">
        <property type="term" value="F:phosphatidylcholine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008429">
        <property type="term" value="F:phosphatidylethanolamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061817">
        <property type="term" value="P:endoplasmic reticulum-plasma membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04030">
        <property type="entry name" value="C2C_KIAA1228"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21681">
        <property type="entry name" value="SMP_ESyt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000025">
        <property type="entry name" value="Extended synaptotagmin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000093">
        <property type="entry name" value="Extended synaptotagmin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037752">
        <property type="entry name" value="C2C_KIAA1228"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051634">
        <property type="entry name" value="Extended_Synaptotagmin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039010">
        <property type="entry name" value="Synaptotagmin_SMP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45761:SF4">
        <property type="entry name" value="EXTENDED SYNAPTOTAGMIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45761">
        <property type="entry name" value="EXTENDED SYNAPTOTAGMIN-LIKE PROTEIN 2, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17047">
        <property type="entry name" value="SMP_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00360">
        <property type="entry name" value="C2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="13" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="18">
        <location>
            <begin position="116"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="17">
        <location>
            <begin position="284"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="17">
        <location>
            <begin position="449"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005027074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="570" mass="64394" checksum="47A83AD66CEA9813" modified="2022-01-19" version="1">MGGGGGEPAALGRGTPRSRGSAMDPAASRPAAPQRALLSSAGRALLWLGPVYLAGYLGLSGSWLLLGLALALGWERNRRGKRERLAAASVLLEDEREAVRRGLAARHLPAWVHFPDVERVEWLNKVLEQAWPYFGTIMEKTFKEVLEPKIRAKSVHLKTCSFTKIQFGEKCPRINGVKVYTKEIDRRQVILDLQICYVGDCEIHMDISKFNLGVKGVQLYGTLRVILEPLLTDAPFIGAVTLFFMQKPHLEFNWAGMSNLLDVPGINVMSDSLIQDYIAARLVLPNRITVPLKKNMSIAQLRFPVPHGVIRVHLLEAENLVQKDNFLGAIRGKSDPYALLRLGTVQYRSKTISRDLNPVWNETFEFVVHEVLGQDLEVDLYDADPDKDDFMDKDQDSSLGTSVVCLSHLLKDPNMTLDQRFQLDHSSSDSFIKIKLVLRVSCLLGTEMPLGEIQLTVRYASIRQSLVVLVNGCRNLIPSSNRGVDPYVRIYLLPDRRWTSRKKTSVKKKTLNPQYDEKFEFFESLEEVKKRTLDVAVKNSRPFISQEKKELGKVRIDLSQEDLIKGFTQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UDU0</accession>
    <name>A0A8C2UDU0_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Disintegrin and metalloproteinase domain-containing protein 9-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC107316254</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015723015.1">
        <property type="nucleotide sequence ID" value="XM_015867529.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UDU0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005034966.1">
        <property type="protein sequence ID" value="ENSCJPP00005025735.1"/>
        <property type="gene ID" value="ENSCJPG00005020168.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107316254"/>
    <dbReference type="KEGG" id="cjo:107316254"/>
    <dbReference type="GeneTree" id="ENSGT00940000166847"/>
    <dbReference type="OrthoDB" id="5951731at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04269">
        <property type="entry name" value="ZnMc_adamalysin_II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000002">
        <property type="entry name" value="Disintegrin and metalloproteinase domain-containing protein 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.70.10:FF:000001">
        <property type="entry name" value="Disintegrin and metalloproteinase domain-containing protein 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.70.10">
        <property type="entry name" value="Disintegrin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006586">
        <property type="entry name" value="ADAM_Cys-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018358">
        <property type="entry name" value="Disintegrin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001762">
        <property type="entry name" value="Disintegrin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036436">
        <property type="entry name" value="Disintegrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002870">
        <property type="entry name" value="Peptidase_M12B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034027">
        <property type="entry name" value="Reprolysin_adamalysin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF122">
        <property type="entry name" value="DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08516">
        <property type="entry name" value="ADAM_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00200">
        <property type="entry name" value="Disintegrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01562">
        <property type="entry name" value="Pep_M12B_propep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01421">
        <property type="entry name" value="Reprolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00289">
        <property type="entry name" value="DISINTEGRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00608">
        <property type="entry name" value="ACR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00050">
        <property type="entry name" value="DISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57552">
        <property type="entry name" value="Blood coagulation inhibitor (disintegrin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00427">
        <property type="entry name" value="DISINTEGRIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50214">
        <property type="entry name" value="DISINTEGRIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="744"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="13">
        <location>
            <begin position="266"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Disintegrin" evidence="12">
        <location>
            <begin position="466"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="688"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="775"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="785"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="832"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="404"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="403"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="524"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="712"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005025735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="846" mass="93573" checksum="11237DE18EC0AF3F" modified="2022-01-19" version="1">MNFYFPVSLAEMKYPRAFSVVYLQSRLFLILLVPCGAAESQVSAGNLVMLKHGLLFFALGLYLTGNSHWMKGVCSEEASRLSTFEIIIPQRLTGRESQRPFFHEEHSDDNLSYSIKTRNGTYLLMLKKNKDLVSKDFMLYTYGKNGKLEATQSKNKTHCYYHGAVEGMADSVLALSTCDGLRGIVYIAGTWYGMEPLNTSRTFEHRFYQLEDLQHVPFHCGVLNDSLHHEMQMFVKQSVEYAFSSNSTSNREKLLRKKRAVLPQKSYVELFVVVDNHRFLQKNSDPAAVQKEIVELINYVDGMYSALNIQIVLVGLEIWTDKNQISVMEGSAGDVLSRFVSWRQKNLLKRSRNDVSHLIIGRGSYSGSIGMAFVGTVCSQVQGGSISTLNHDHVLRHATVVAHELGHNLGMKHDDKRCPASYIMYSTDKGSRNFSSCSADDFENLVLNGGGICLRNPPKTSNVYKEPVCGNNVIDNDEECDCGKPQECTNPCCDAATCKLTSGSQCAQGLCCKNCKFKAAGTECRSKMDFCDLPEYCNGSYAYCPDDVYIMNGYPCNNMKAYCYYGVCQSFDSQCEAIYGKGARKAPDLCFKTANIKGDRFGNCGMRGGVYKKCPLEHSLCGKLQCTSVSLQNLPAWSVVNNASGVLCWSSDFDLGSDIPDPAQVHDGTACGEKKACVAFECVDASHLGYSCDVKQKCNDNGVCNNNGNCHCNSGWAPPFCNQSGYGGSIDSGPAHMDTSLRDGLLVFFFLVLPILIVSVIAVIKRDAIKRKFCRKSRRQHRDNNAQQPKQSNSPTHAPRNDQAAAASSDVFTVPHFPAPRQAGQTQFPAVPSRPPRPTVPPRAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UE92</accession>
    <name>A0A8C2UE92_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-mRNA-splicing factor 38B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">PRPF38B</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">May be required for pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the PRP38 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015724892.1">
        <property type="nucleotide sequence ID" value="XM_015869406.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UE92"/>
    <dbReference type="Ensembl" id="ENSCJPT00005036795.1">
        <property type="protein sequence ID" value="ENSCJPP00005027176.1"/>
        <property type="gene ID" value="ENSCJPG00005021086.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107317120"/>
    <dbReference type="KEGG" id="cjo:107317120"/>
    <dbReference type="CTD" id="55119"/>
    <dbReference type="GeneTree" id="ENSGT00730000111085"/>
    <dbReference type="OrthoDB" id="3881at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005037">
        <property type="entry name" value="PRP38"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23142">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 38A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03371">
        <property type="entry name" value="PRP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="232"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="246"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="259"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="294"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="348"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="425"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="454"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="480"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="499"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="514"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005027176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="549" mass="64890" checksum="8E27CDC6EEA71673" modified="2022-01-19" version="1">MANNSPAVGAGNCQGQQAAQHQPGAMPPAQQQLQSGAPKPAASGKQGNVLPLWGNEKTMNLNPMILTNILSSPYFKVQLYELKTYHEVVDEIYFKVTHVEPWEKGSRKTAGQTGMCGGVRGVGTGGIVSTAFCLLYKLFTLKLTRKQVMGLITHTDSPYIRALGFMYIRYTQPPTDLWDWFESFLDDEEDLDVKAGGGCVMTIGEMLRSFLTKLEWFSTLFPRIPVPVQKTIDQQIKSRPRKIKKDGKEGMEEIDRHPERRRSRSPRRSISPRRSPRRSRSRSHHREAHGSSSFDRELERERERQRLEREAKEREKERRRSRSTDRALERRRSRSRERYRSRSRSRDRKGDRRDRDREREKENERSRKKERDYDKDRGSEREKDSDRSRERSKERKSKGDTEERRHKDDKDDKKHRDDKRDSKKERKHSRSRSRERKHRSRSRSKNTGKRSRSRSKEKSSKHKSESKEKSNKRSRSRSRGRTDSVEKSRKRDHSPSKERSRKRSRSKEHSHKHDHSDSKDHSDKHDRRRSQSTERENQEKQQKNKDETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UH10</accession>
    <name>A0A8C2UH10_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Caudal type homeobox 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">CDX2</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Caudal homeobox family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015707543.1">
        <property type="nucleotide sequence ID" value="XM_015852057.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UH10"/>
    <dbReference type="Ensembl" id="ENSCJPT00005035565.1">
        <property type="protein sequence ID" value="ENSCJPP00005026251.1"/>
        <property type="gene ID" value="ENSCJPG00005020437.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107308286"/>
    <dbReference type="KEGG" id="cjo:107308286"/>
    <dbReference type="CTD" id="1045"/>
    <dbReference type="GeneTree" id="ENSGT00940000161261"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017053">
        <property type="term" value="C:transcription repressor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008327">
        <property type="term" value="F:methyl-CpG binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009948">
        <property type="term" value="P:anterior/posterior axis specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001568">
        <property type="term" value="P:blood vessel development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008333">
        <property type="term" value="P:endosome to lysosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045197">
        <property type="term" value="P:establishment or maintenance of epithelial cell apical/basal polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060575">
        <property type="term" value="P:intestinal epithelial cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045597">
        <property type="term" value="P:positive regulation of cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014807">
        <property type="term" value="P:regulation of somitogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035019">
        <property type="term" value="P:somatic stem cell population maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048863">
        <property type="term" value="P:stem cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000089">
        <property type="entry name" value="Caudal type homeobox 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006820">
        <property type="entry name" value="Caudal_activation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047152">
        <property type="entry name" value="Caudal_homeobox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000047">
        <property type="entry name" value="HTH_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24332">
        <property type="entry name" value="HOMEOBOX PROTEIN CDX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24332:SF27">
        <property type="entry name" value="HOMEOBOX PROTEIN CDX-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04731">
        <property type="entry name" value="Caudal_act"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00031">
        <property type="entry name" value="HTHREPRESSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="179"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="181"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="106"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="238"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="106"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005026251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="280" mass="29590" checksum="87C1771F0D7CB733" modified="2022-01-19" version="1">MYVSYLLDKDGPMYPGPVRHSGGLNLAAQNFVGAAQYADYGGYHVNLDGAQSPGPAWPAPYAAPLRDDWGAYGQGAPPPAAAAAAVHGLNGGSPAAAMAYSPADFHHHHHHHHPHAHHHAGPAPHCSAGGMQPLGAAPAASSAASAAPESLSPGGQRRGLCEWVRKPAQAPLGSQGKTRTKDKYRVVYTDHQRLELEKEFHYSRYITIRRKAELASSLGLSERQVKIWFQNRRAKERKINKKKLQQAQPGAAEPLSPAAPPLPGPAAAPPPAGLGPTAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UHP8</accession>
    <name>A0A8C2UHP8_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Interleukin-like protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UHP8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005036598.1">
        <property type="protein sequence ID" value="ENSCJPP00005027024.1"/>
        <property type="gene ID" value="ENSCJPG00005020987.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000235545"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033982712" description="Interleukin-like protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005027024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="166" mass="19137" checksum="0AEEB867ECA12E05" modified="2022-01-19" version="1">MHPYMLLLLLCGWSASSHCLPPKKMLLLQSKNKSSLIEEMLCLLENENTTLNKHLTTPTCIRSTNCACNNTEVFIHQLNSLESPCMKIVKSDMRKLRDSCSILKRKSAHENSCSEMKTDFPKFRDNLEGFLRWLSQMDHCRNITRDELDLDGRSESSCSLHCTKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UJC1</accession>
    <name>A0A8C2UJC1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sushi domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2UJC1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005036858.1">
        <property type="protein sequence ID" value="ENSCJPP00005027235.1"/>
        <property type="gene ID" value="ENSCJPG00005021128.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154386"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001851">
        <property type="term" value="F:complement component C3b binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006956">
        <property type="term" value="P:complement activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.70.10:FF:000026">
        <property type="entry name" value="Complement inhibitory factor H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.70.10:FF:000060">
        <property type="entry name" value="Complement inhibitory factor H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051503">
        <property type="entry name" value="ComplSys_Reg/VirEntry_Med"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
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    <sequence length="239" mass="26814" checksum="4E35C93938677B2F" modified="2022-01-19" version="1">MCLWNSLFISYCLSLCFKEKPCSPPQPVEYADDPRLVNQNLKMEKEGRTVYLAGAVLKFTCHSGFELHGSSEISCSMGNWSSSPTCSGNVRRSEKCGPPPDIENGDILSFPLPEYSQGAILKYKCPNFYILEGSQQIKCINGQWTNPPVCLVACTAAEEDMNNNNIELKWRGERKLYSKSGDFIEFDCKIGNVKDPESSPFRVQCINGTLKYPRCKTGSKSSPSVIVWLLFFAYLVQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UJR7</accession>
    <name>A0A8C2UJR7_COTJA</name>
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        <recommendedName>
            <fullName evidence="22">Voltage-dependent T-type calcium channel subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="primary">CACNA1G</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="27" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="27" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="22">Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="22">Membrane</location>
            <topology evidence="22">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1G subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="ENSCJPP00005027828.1"/>
        <property type="gene ID" value="ENSCJPG00005021465.1"/>
    </dbReference>
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        <property type="component" value="Chromosome 18"/>
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        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:synapse"/>
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        <property type="term" value="F:high voltage-gated calcium channel activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <keyword evidence="3" id="KW-0813">Transport</keyword>
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            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="1485"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="21">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00061006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR602077-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR602077-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU003808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005027828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="2391" mass="267856" checksum="AA962B30E84A6516" modified="2022-01-19" version="1">MDEDGPRAADEEPEPGRAKTFIRLNDLSGAGGRPGPGEREVGSGDSEAEGLPYPALAPVVFFYLSQESRPRSWCLRLVCNPWFERVSMLVILLNCVTLGMFHPCEDIACDSPRCRILQSFDDFIFAFFAVEMIVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSIPYTVDLERYYQTENEDENPFICSQPRENGMRYCRSIPTRREEGLECTLDYYSYNDTTNTSCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMKEQRVRYLSNASTLASFSEPGSCYDELLKYLVYIARKGSKQLVELYRVAGVRMGFLASPASKAGAERHAGKRRSRRRSSVHHLIHHHHHHHHHYHLGNGNLRAPHASPEISDVDTGSLHNGTNRLMLPPSAPNPHMASTATASGTESVHSIYHADCHVEPVRCRAASPQPSPEDIPRSVVMGSKVYPTVHPSTSHEARKEKSLGEAAVGAGSSTLSGLNIPPGPYSTMHKLLETQSTGPCPSSCKITSSCTKLDGSSRSPESCPYCLKALANEAEQTDNETDSDSEGVYEFTQDAHYSDQRDPQHGRAWARSSSRVLAFWRIVCETFRKIVDSKYFNRGIMIAILINTLSMGIEYHEQPEELTNALEISNIVFTSMFALEMLLKVLVYGPFGYIKNPYNIFDGIIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFMPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEEISKREDAGGQLSCVQLPGDSAAGDASKSDSEGELFLRSLEEEGGLKKNLSNPVCDEHPELKKSLTPPLIIHTAATPMPMPKSAMFGDAAQGYESRRASGVSMDPAAYELKSPPSARSSPHSPWSTGSSWPSRRSSWNSIGRAPSLKRRGQSSERRSLLSGEGKESSEDGESSDEEHSSRAGSVNGSLPHRMESLEAKGSFDLQDTLQVPSLYRTSSMHSSRTTASEHQDCNGKTSPGLLVHQLHLDDPRPDCDDADDEGNMSKRDRMKAWVRAHLPTCCKERDSWSIYVFAPHSRFRLMCNKIITHKMFDHIVLVIIFLNCITIAMERPKIEPHSAERIFLTLSNYIFTVIFLTEMTVKVVALGLCFGEKAYLKSSWNVLDGVLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFFICQGEDTRNITNKSDCAEASYKWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPVMNYNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEEEEAKRREEKRLRRLEKKRRNLMLDDVLMESTASVVPEAQCKPYYSDYSRFRFLIHQMCTSHYLDLFITGVIGLNVITMAMEHYQQPKVLDEALKICNYIFTVIFVLESVSKLIAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDDTHPCEGLSRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELEMEMKTISPGQHSPSDIFTWMGGVGGERPESPRGCPHPLQIKVDSQLSLVYPMERHLFDTISLLIQESLEGELKLMDNLSGSVCHHYALPAPEYCNSENQIPLAEMEALSLTSDILSEKSWSLALTDDSFPDDINTHLLSALESNVHTLDLLSVRKPSVGRTHSLPNDSYMFHTSQPLSRPSTASLRDGNPAQHKAHSGSKASVQSQPADTSSLLQIPKDHFHHVRAHDPLVRESKPPVAAPVHSPSAERLLRRQMAIRNDSSDSKENLHAELSELPNPEIPNLAAWSRASVHTQQHSHNQYNVSKQALTSCACVDSYQETPGDSMDQEVSETNSSSEPFPSETCTASSACSDVQPLSPKRNIGNTGSVTLKDLKKYHSVDTQGLLKKPPSWLDDQRRHSIEICSMENSPQHHSTSSSSGFISQVVSEMEGLQGTRQKKKLSPPCISIDPPSEQGLLPRGPHSISPARGDTCLRRRAPSCDSKDSMDTGDSLLPDSMSASPTPKKDLLTLPSFSFDRNEMEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UJV1</accession>
    <name>A0A8C2UJV1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Short myomegalin-like EB1 binding protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UJV1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005037123.1">
        <property type="protein sequence ID" value="ENSCJPP00005027466.1"/>
        <property type="gene ID" value="ENSCJPG00005021293.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183190"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007098">
        <property type="term" value="P:centrosome cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090063">
        <property type="term" value="P:positive regulation of microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903358">
        <property type="term" value="P:regulation of Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056273">
        <property type="entry name" value="CDK5RAP2_MYOME_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052593">
        <property type="entry name" value="MT-associated_AKAP9-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040947">
        <property type="entry name" value="SMYLE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46501">
        <property type="entry name" value="MYOMEGALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46501:SF2">
        <property type="entry name" value="MYOMEGALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23246">
        <property type="entry name" value="CC_CDK5RAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18615">
        <property type="entry name" value="SMYLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ZAD" evidence="3">
        <location>
            <begin position="4"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Short myomegalin-like EB1 binding protein N-terminal" evidence="4">
        <location>
            <begin position="114"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="CDK5 regulatory subunit-associated protein 2/Myomegalin coiled coil" evidence="5">
        <location>
            <begin position="972"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="207"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="303"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="415"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="523"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="642"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="781"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="899"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="236"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="309"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005027466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1111" mass="125273" checksum="4C1C9B460DE3DF70" modified="2022-01-19" version="1">MKETCRICARELCGNQRRWIFHTAAKLNLQVLLSHVLGRELCRDGRGEFACSKCAFMLDRIYRFDTVIARIEALSIERLQKLLLEKDRLKFCIASMYRRNNEEPGTDERAGDGTVDLSNLPDARYAALLQEDFAYSGYEYWTDQDEHVLEPHSCHASEGAAGRPRRCRGCAALRVADADYEAICKVPRKVARSISCGLSSRWSVSMGNEESSVCDPAESAGARGPVDGESMEEGTPASSVESLDTTVEASAPQQKDEDADKGVKGNGKCDDFAEDRTTPSSSLSGNRLELALSLIKGLDYKPIQSPRGSRLPIPIKSSLPPPKLSRDLADGSASAGLAYAGSGFLNADRKSFSRAPLALPLEIPELQELWDDLCEDYMPLRVQNLQDEHQKPAPGDSASREHTANLCATEPQGKIQQVEATNQLLQEKLNELNFELKSVRETSQRQDHTIQSLNEALKSKESETEELYHVIEGQNETMAKLQDMLHRSQLGQLQMSEGTPSSQEQQVALLDLQNTLFCTQLEVQKLKRAQRQKEHQLVEAKRAAQLLESTVHEEEQQKEATWKHNQELRAVVQQLQAELQEKAQQIQTVEWEKCRELQAQEQRVQCLSQHLARKEQLLQESRELLQCQQSLGRSSAAMDAMLEKLQQRVSDRDAALERAVDEKFCALEEKEQELQQLRLSIKERGGDLERLRNVLSSNEATIHSLESLLKAKTLELEQMSATCENLRWLKEEIEAKSCSRQKEQEGIIQQLQTCLHDRNKEVEELTATLLCKLGPGQSEVAEELCLRLQRKEKMLQELLSDRNRQAMEHDAEIRELLQAMSTKEQWSKATTEKMVHALAERNCELQLLRQHVLRKEPVGIQATGTSLLKQDKQQPVQEILQRACGAAALAGPPQQDNSCLTEEASAAELEKDLANAREELELMAKKERESRRELAALQSVVTTQEEELQVQASDIESLTRTIQIKEDLIKDLQMQLVDPEEIPAVERLTQEVLVLREKVAVAESRGQEATGNRRQQLLLMLEGLVAERNRLNEALQAERQLYSSLVKFHTHPDSAARDRTLQVELEGVQELRGQLEEALGRSLERLSRLDTQGPIGGGEQERVRVLPQHAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y5C9</accession>
    <name>A0A8C2Y5C9_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y5C9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005001926.1">
        <property type="protein sequence ID" value="ENSCJPP00005001117.1"/>
        <property type="gene ID" value="ENSCJPG00005001189.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003006">
        <property type="entry name" value="Ig/MHC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003597">
        <property type="entry name" value="Ig_C1-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050380">
        <property type="entry name" value="Immune_Resp_Modulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23411">
        <property type="entry name" value="TAPASIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07654">
        <property type="entry name" value="C1-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00407">
        <property type="entry name" value="IGc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00290">
        <property type="entry name" value="IG_MHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="6"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005001117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="111" mass="11505" checksum="C680C2332F2947C8" modified="2022-01-19" version="1">VTSIGPTLYPLLPPPSECNDINVTIGCLVTSFIPPPVTISWTITGSSLAPSSAMTSLPVQTSGGTYSQTTALVVPMEEVKGGQFTCRAQHPATKTDVTETIEDGELVLQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y602</accession>
    <name>A0A8C2Y602_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Brain enriched guanylate kinase associated</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BEGAIN</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y602"/>
    <dbReference type="Ensembl" id="ENSCJPT00005004558.1">
        <property type="protein sequence ID" value="ENSCJPP00005002474.1"/>
        <property type="gene ID" value="ENSCJPG00005002736.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161760"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043441">
        <property type="entry name" value="Tjap1/BEGAIN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28664:SF2">
        <property type="entry name" value="BRAIN-ENRICHED GUANYLATE KINASE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28664">
        <property type="entry name" value="TIGHT JUNCTION-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="103"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="149"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="451"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="451"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005002474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="512" mass="57292" checksum="D5F2B03449B34D17" modified="2022-01-19" version="1">MHRDCGLHISQRTVSGELHNIINCTHMSVLHKTKQIPVLICTLFSCPLCYLSMLQLPSDFQERVSIHLEKHGCSLSVPLCHTSYADTIPTCVIAKVLEKPDPNSLSSHLSSPSTRDLNFQDPAGKLGQRPQYKSDIYCSDTALYCPEERRRERRPSVDTQVKDVGFLRSQNSTDSTVEEDGFHSSFSHEAFPEYITSLPTSSSYSSFSVTSEEKENAQANTMTASQQAIYMSNRDELFERKSPAGYEHQGSPRFAKSKPAQHMELADDNENSPTFTRTLPPYANEPFHFSAITPQQALANQKMRNECRSTNLSEEDLPGRWRQLSVEDIGAYSYRNTGRLSPCSFSEQYYSSPIKTGDSRTSPIYASYKADSCSEGDDICQSRLVDSCFLRADSGLNIDISTSCKQDNLPAYKTKESRDQKNERITVQLCSSKNIENSPVLKREYVDVSPNSSAESLNHSSIEASEIHQSSMEQGSHSGIHSKQQQFQRTGSTGLSRKDSLTKAQLYGTLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y607</accession>
    <name>A0A8C2Y607_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">WD repeat-containing protein 20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">WDR20</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="9">Interacts with USP12; promotes translocation of USP12/WDR20 to the plasma membrane. Component of the USP12/WDR20/WDR48 deubiquitinating complex. Interacts with USP46; contributes to the cytoplasmic localization of the USP46/WDR20 complex. Component of the USP12/DMWD/WDR48 deubiquitinating complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y607"/>
    <dbReference type="Ensembl" id="ENSCJPT00005004585.1">
        <property type="protein sequence ID" value="ENSCJPP00005002498.1"/>
        <property type="gene ID" value="ENSCJPG00005002753.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000007686"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035800">
        <property type="term" value="F:deubiquitinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000101">
        <property type="entry name" value="WD repeat-containing protein 20 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051362">
        <property type="entry name" value="WD_repeat_creC_regulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14107">
        <property type="entry name" value="WD REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14107:SF5">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="279"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="423"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="497"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="458"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="497"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00062479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005002498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="596" mass="65572" checksum="125B8FDEC8F98461" modified="2022-01-19" version="1">MAAEGGGKEMNEIKTQFTTREGLYKLLSHSEYSRPNRVPFNSQGSNPVRVSFVNVNDQSGNGDRLCFNVGRELYFYIYKGVRKAADLSKPIDKRIYKGTQPTCHDFNHLTATAESVSLLVGFSAGQVQLIDPIKKETSKLFNEEVSRNLNIVACNVFLISKVLKVRLIDKSRVTCVKWVPGSESLFLVAHSSGNMYLYNVEHTCGTTAPHYQLLKQGESFAVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQDGFLRVINFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVEESDPMEFSGSDEDFQDLHFGRDRANSTQSRLSKRNSTDSRPVSVTYRFGSVGQDTQLCLWDLTEDILFPHQPLSRARTHTNVMNATSPPAGGGGANPGSNGNSITTPGNSVPPPLPRSNSLPHSAVSNAGSKSSVMDGAIASGVSKFATLSLHDRKERHHEKDHKRNHSMGHISSKSSDKLNLVTKTKTDPAKTLGTPLCPRMEDVPLLEPLICKKIAHERLTVLIFLEDCIVTACQEGFICTWARPGKVVSFNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y633</accession>
    <name>A0A8C2Y633_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">PIK3C2G</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18373"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57658"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.154"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:18374"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12709"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.137"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:12710"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015723380.1">
        <property type="nucleotide sequence ID" value="XM_015867894.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015723391.1">
        <property type="nucleotide sequence ID" value="XM_015867905.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015723403.1">
        <property type="nucleotide sequence ID" value="XM_015867917.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032301816.1">
        <property type="nucleotide sequence ID" value="XM_032445925.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005004945.1">
        <property type="protein sequence ID" value="ENSCJPP00005002651.1"/>
        <property type="gene ID" value="ENSCJPG00005002965.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005004948.1">
        <property type="protein sequence ID" value="ENSCJPP00005002654.1"/>
        <property type="gene ID" value="ENSCJPG00005002965.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107316443"/>
    <dbReference type="KEGG" id="cjo:107316443"/>
    <dbReference type="CTD" id="5288"/>
    <dbReference type="GeneTree" id="ENSGT00940000159982"/>
    <dbReference type="OrthoDB" id="67688at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005942">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016303">
        <property type="term" value="F:1-phosphatidylinositol-3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035005">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044788">
        <property type="term" value="P:host-mediated perturbation of viral process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043491">
        <property type="term" value="P:phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04012">
        <property type="entry name" value="C2A_PI3K_class_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05177">
        <property type="entry name" value="PI3Kc_C2_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000001">
        <property type="entry name" value="Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000013">
        <property type="entry name" value="Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000026">
        <property type="entry name" value="Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000125">
        <property type="entry name" value="Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037707">
        <property type="entry name" value="PI3-kinase_C2_gamma_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002420">
        <property type="entry name" value="PI3K-type_C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000341">
        <property type="entry name" value="PI3K_Ras-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF29">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00792">
        <property type="entry name" value="PI3K_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00613">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00142">
        <property type="entry name" value="PI3K_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00145">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51547">
        <property type="entry name" value="C2_PI3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51546">
        <property type="entry name" value="PI3K_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K-RBD" evidence="13">
        <location>
            <begin position="279"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="C2 PI3K-type" evidence="14">
        <location>
            <begin position="513"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="domain" description="PIK helical" evidence="12">
        <location>
            <begin position="676"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="11">
        <location>
            <begin position="921"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="10">
        <location>
            <begin position="1233"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="9">
        <location>
            <begin position="1362"/>
            <end position="1479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005002654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1479" mass="169522" checksum="8027CDC321CA6D15" modified="2022-01-19" version="1">MAYFGKVPFSGDEFYEGHSGDQASYLAYHSGSYGKVYLGFDQIVDEVNNEFFFYGSSHLHHPEEEHFFTSDIFSLNVPEQQLCSQPSVACCELHSENFVPHWQQGSMSPKIGFKSSLLSDDGNFSLVDSYPYNQEREIYRWNSITPVTNVFNSNVERSYTYWNYQIGFDNVDAQCPVSLNNYPFGQRRDENGKGETCLTSTSRRFSIGPTWPNSPGHDKEITSWSIQLIKADQGSNENVISFCNTVEKIRNAYPACDLKTNSGKIWSVVTKFPDNILGKTRFRISIWTDSSPSPLLLTQHAGCITHDLIVEILRCTNQYPVHEECFLSVCGSDEVLQNNHSLGSHESLRKATTDIHLHLHTTTNLKQSLARMHEDDQNKFSVNELLEYTCAWRLTRQNLVAALRKYRGQVEHLLQNEPHNVDYVIEVTKEICSVLCFVETREITNAVKKLRAVPLVKTQDSLQRVEAQALMEAAVTELSMAISHLIHVYSSSIDTDFQVANAPRSPSHADISLDSQLSFTVYAAHNIPEAWVNRYKVFSFSCLLTYAGKTICQVKICKNIPIRKSFFFLTDWNEKINFPLRIKALPRETMLTIKLLGLNSASKTTEVLAWTCCPLYQKEQLIHGTVLLSMKLYSMLPAAMITPGICSTDAPTSVMLQFEFPETDLKFINPEPEERRDDLEEPTEECLKHIARLSQAHSLLLLSEQQKRILWFYRYYCNNQNCSLPLVLGSAPSWDRTTMSEMYSVMRKWRFSNPVEALGLLTFSFPDKDIRRTAVQQIENLSNDELLEYLPQLVQVLKFEWSLEGPLVKLLLNRSLQSIQVAHQLYWLLKNAQNEVHFKTWYRKLLAALQFTAGKTLSNEFSKEEKLNRILEDIAEKVKAASDTKRKEVLKMELNRLQQFFQEVKVCRLPLNPALVVQGIEADSCSYFTSNAFPLKISFINATAPSGNINIIFKIGDDLRQDMLVLQIIRVMDNIWLQEGLDMQIIIYRCLSTGKGQGLVQMVPDATTLAKIHRESGLIGPLKENTIKKWFRHHHRLESSYQEAIRNFFHSCAGWCVVTFILGVCDRHNDNIMLTNAGHMFHIDFGRFLGHAQTFGSIRRDRAPFIFTSEMEYFITEGGKNPQRFQEFVELCCRAYNIVRKHSQLLLNLLEMMLHAGLPELNSIQDLKYVYDNLRPQDSDLQATSYFTRKIKESLECFPVKLNNLIHTLAHMSLTSSTKLPSQETVPQEWMMLNAEKSIARATILGFNKKSDYLYLVQVVQTCNVVTFVEKSFDQFSELHSNLQKQFPSHTLPEFPHSWHIPFTDLEHKRVKDLNLYLKQLLNGSRKLANNELVLRFFLNWSKHTLTETASSVTSGPQSTDGTPGVQLVISYEGTHLTVMLKHMRNIRLPDGSAPSVHAEFYLLPDPDEVNRRKTRTVPKTTNPTFNEIVVYNKVMQLEGRILKLVVKSKGTFVGAVNIQLSRVHLNEEKWYPLGNSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y6P6</accession>
    <name>A0A8C2Y6P6_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pancreas transcription factor 1 subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Pancreas-specific transcription factor 1a</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">PTF1A</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
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        <scope>IDENTIFICATION</scope>
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    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
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    <sequence length="275" mass="30225" checksum="71850BECFD2E9F37" modified="2022-01-19" version="1">METVLLEHFPAGLDSFSSPPYFDEEDFFPEPPPREALGADGLPEPDVDFFGRQLHEYYRDGGDPDGGYCCEAAAAAFPPSPASPGFAYECCGAAGAGLLSPGGRLRALGSAKRRRRERSEAELQQLRQAANVRERRRMQSINDAFEGLRSHIPTLPYEKRLSKVDTLRLAIGYINFLSELVRSDLPLRSAGGDGPSQPKKIIICHRGTRSPSPSDPDYGLPPLAGHSLSWTDEKQLKEQNVIRTAKVWTPEDPRKANAKPSLSDIENEPPLGFVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y791</accession>
    <name>A0A8C2Y791_COTJA</name>
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        <recommendedName>
            <fullName evidence="16">Macrophage mannose receptor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">LOC107309032</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_015853441.2"/>
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        <property type="protein sequence ID" value="ENSCJPP00005005613.1"/>
        <property type="gene ID" value="ENSCJPG00005004408.1"/>
    </dbReference>
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        <property type="component" value="Chromosome 2"/>
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        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:D-mannose binding"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="beta-trefoil_Ricin_MRC1"/>
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        <property type="match status" value="8"/>
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    <dbReference type="CDD" id="cd00062">
        <property type="entry name" value="FN2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Fibronectin 1a isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="macrophage mannose receptor 1"/>
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    </dbReference>
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        <property type="entry name" value="Macrophage mannose receptor 1"/>
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        <property type="entry name" value="Mannose receptor C-type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Mannose receptor C-type 1"/>
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        <property type="entry name" value="Mannose receptor, C type 1"/>
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        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
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    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000562">
        <property type="entry name" value="FN_type2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036943">
        <property type="entry name" value="FN_type2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013806">
        <property type="entry name" value="Kringle-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24562">
        <property type="entry name" value="CysR_MRC2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00040">
        <property type="entry name" value="fn2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00013">
        <property type="entry name" value="FNTYPEII"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00059">
        <property type="entry name" value="FN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57440">
        <property type="entry name" value="Kringle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00023">
        <property type="entry name" value="FN2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51092">
        <property type="entry name" value="FN2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13 17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0430">Lectin</keyword>
    <keyword evidence="12 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 19" id="KW-0732">Signal</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034837836" description="Macrophage mannose receptor 1" evidence="19">
        <location>
            <begin position="20"/>
            <end position="1448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1383"/>
            <end position="1404"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-II" evidence="21">
        <location>
            <begin position="162"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="20">
        <location>
            <begin position="229"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="20">
        <location>
            <begin position="370"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="20">
        <location>
            <begin position="511"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="20">
        <location>
            <begin position="655"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="20">
        <location>
            <begin position="805"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="20">
        <location>
            <begin position="949"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="20">
        <location>
            <begin position="1093"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="20">
        <location>
            <begin position="1233"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="167"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="181"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00071860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005005613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1448" mass="165759" checksum="5D323510C600AFF5" modified="2022-01-19" version="1">MAVYLLVIFLFSFCTSLQASDNGIFLIYNEDSKLCAQAQNSSSVITTMCNENNELQRFRWISATQLLSMGMKLCLGVLTKDDEAAITLETCNRTSELQRWECKDEALSIQGKDLFLSYGKGKGKKMRLSKESGKGSRWRIHGTVGSICSRPYEDIYTLGGNTFGAPCVFPFKFNGKWFAECVRRTEYASPLWCATTSDFDKDRRFGYCPSKDNLQKDFWKTNPLTETYYQINSNSLLTWQQARRSCQQQNAELLSIANPHEEMFLLGLTSDLGFSAKLWTGLVRRLDSSWEWTEGSPLRYLNWAPGNPSVELIKMCGTFQGRNGKWENVACNQKLGYICQKRNSSTVDNSSTVPSGDMKPVKCPGEWVAYAGHCYRIYRTPKIWKQAQSSCRKEDGDLTSIHNVEEYSFIVSQLGYKPDDELWIGLNDFRHQMYFEWSDGTPVTYTKWHQRQPTHTPNKADCIVMNGEDGFWADSSCERKLSYICKRKPLAEESGEAEVTYPGCQKGWMKHGFYCYSIGELPATFSEAKRICEENKAHLATVIDRYEQAFLTSVIGYKPVKYFWIGLSDMEEQGTFRWAGGDPVIFTHWNMGMPGSEPGCVAMRTGTSAGLWDILNCEEKNLFLCKQLVEGATPPPPLTTPPLPSCPDEWQSIPQSSFCFKIFQRGREKMQTWFGARDFCRAIGGDLACVHSEEEQKLISSLNKDYRHKSYWMGLNALDSDGGFTWCDGSPVNFQKWANGEPNNYDGNEKCGVFYGYNDMKWNDIFCEHMQDYVCQIKKGASLKPEPTSTFDYEYIVSEDDWIIYNHKEYYFSKEAMPMEKARDYCKKNGGDLAIIESESERTFLWKYTFYRDRGNNFFIGLTVSLDKTFRWVDGTTANYVAWAPNEPNFANNDENCVVMYVQTGTWNDLNCGKVEFFICERLNSTVRPSISPTVPPPKGGCPEDWLQFDNKCFKAFGLDENYTLTWHAARNNCISFGGNLATISKKENQAFLMSLLKNTATDAWIGLNDINQEHVYLWTDGSPVYYTNWAKGSRSYYSKDDCVYMKKNPIEQAGKWKDEDCKASKSYICQRNTDPKLKSSQAVVPMFGFNNYGDDRYAVINYKMNWEEAQKNCKDQYADLASILDPYVEAYLWLQILKHGEPVWIGLNSNMTRGLYMWSDRRRSRYHNWASGEPNKNAACAYLDLDGFWKTTSCNESFLSLCKQSDELIPTESPQLPGKCPEPKHGRSWIPFRGHCYYVHTTSEVSWPDASMMCIQMGASLVSIEDPAEMNFLLLYLSPLASDFRKFWIGLFKNIEGEWMWTDRSVVEFVNWEKGEPTTIYDEHCVDMDISSGAWRNYYCSVDHNFICKIPKITEVEPTHDSSVNQASKREAAVSSSHSRGVMIVTLIFLLLAGTGLIVYFFYKRRHEQTTVTASFGNAIYCGSPDPGTRESKCLVTNMEENEQAMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y8N5</accession>
    <name>A0A8C2Y8N5_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 18 open reading frame 63</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">C18orf63</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y8N5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005012453.1">
        <property type="protein sequence ID" value="ENSCJPP00005008172.1"/>
        <property type="gene ID" value="ENSCJPG00005007359.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000007627"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008584">
        <property type="term" value="P:male gonad development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031643">
        <property type="entry name" value="DUF4708"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28495:SF1">
        <property type="entry name" value="GENE, 17266-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28495">
        <property type="entry name" value="HYPOTHETICAL PROTEIN LOC100359752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15813">
        <property type="entry name" value="DUF4708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4708" evidence="2">
        <location>
            <begin position="7"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="520"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="571"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="690"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="524"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="694"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005008172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="743" mass="82813" checksum="829BCE32EF5EACFF" modified="2022-01-19" version="1">MNGRRHQSLFFASLPELQKLCAATITLSLQLPESEMRSTQIKVCRQLIFLYQEVLSAPVIGTLNQISVIMAIPFYKSGLCEAYVKRQEATLEAPQRVDPTILQTCLSYTLTARLAPRWNKAGHLLVQGKDFLSQTGRQNAVVLDVNVSETQLCISVEACSVRLPPPELGDFDILTNTIKQFESNENAVIDSHSILANWCYVLPSMKMGQIISISHRIPPESPFHSYEEFQMHWKNLYGYILPDDIEERKIYLSVYFKPIGERLFTYPLRCIRSQPVQYFPRTDSESVLNSFISDVKAKFSHLCGFPVRMTSKALYATQELTRIPAHEIQSESMKLAGEMVCVVSLTQTPPKKPTLANVSSSRSTENSHWMEHLIKEPKPHTSSSKGSVEKISVEATEKLIDRQIAGISELPLQKSLGVSGSSAFELSPKKLSKIIPIFKGSLMKMNGNATNQTNGKKRKNAEKQSPVKSVKSSMLTVCKSSLTQVYKPATCSGSLQIITEKAYVKQDVSVFQRKTETGGQMIKSDSSSNSAVGWSSSEVGHNKANSPSLLKNVRPVHQKSDISPKLNAFATSTSSFRGGKNSTSQNTTKVLRKQQQSKNVYLQIGKSENEMTNSSLSQQQSKKLNEGPRLNIHESILNDTVCTDENDESKASYHSKNCIAKTSCLHTNSVYDQMLTGHKYLTRDEAVTSKLTHSTKESNREASVKKGSARKRQASKRSLMYLRTSELCDLYSVYVMSLLPVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y999</accession>
    <name>A0A8C2Y999_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Zinc finger and BTB domain-containing protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">ZBTB14</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Transcriptional activator of the dopamine transporter (DAT), binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. Binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. Transcriptional repressor of MYC and thymidine kinase promoters.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Interacts with ZBTB21.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015710865.1">
        <property type="nucleotide sequence ID" value="XM_015855379.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y999"/>
    <dbReference type="Ensembl" id="ENSCJPT00005014621.1">
        <property type="protein sequence ID" value="ENSCJPP00005009828.1"/>
        <property type="gene ID" value="ENSCJPG00005008602.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107310061"/>
    <dbReference type="KEGG" id="cjo:107310061"/>
    <dbReference type="CTD" id="7541"/>
    <dbReference type="GeneTree" id="ENSGT00940000158052"/>
    <dbReference type="OrthoDB" id="6425912at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016235">
        <property type="term" value="C:aggresome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003279">
        <property type="term" value="P:cardiac septum development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060976">
        <property type="term" value="P:coronary vasculature development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003170">
        <property type="term" value="P:heart valve development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001822">
        <property type="term" value="P:kidney development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd18204">
        <property type="entry name" value="BTB_POZ_ZBTB14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000147">
        <property type="entry name" value="POZ-, AT hook-, and zinc finger-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000316">
        <property type="entry name" value="Zinc finger and BTB domain-containing 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000762">
        <property type="entry name" value="Zinc finger and BTB domain-containing 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000766">
        <property type="entry name" value="Zinc finger and BTB domain-containing 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000054">
        <property type="entry name" value="Zinc finger and BTB domain-containing protein 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000145">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050457">
        <property type="entry name" value="ZnFinger_BTB_dom_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46105">
        <property type="entry name" value="AGAP004733-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46105:SF28">
        <property type="entry name" value="ZINC FINGER PROTEIN 37-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BTB" evidence="17">
        <location>
            <begin position="36"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="275"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="303"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="331"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="359"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="387"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="130"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00060304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00062591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00070994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005009828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="448" mass="51004" checksum="B0853974512898E8" modified="2022-01-19" version="1">MEFFISMSETIKYNDDDHKTVFLKTLNEQRLEGEFCDIAIVVEDVKFRAHRCVLAACSTYFKKLFKKLEVDSSSVIEIDFLRSDIFEEVLNYMYTAKISVKKEDVNLMMSSGQILGIRFLDKLCSQKRDVSSPEENTQSKSKYCLKINRPIGEPNDTQDDEVEEIGDHDDSPSDVTVEGTPPSQEDGKSPTTTLRVQEAILKELGSEEVRKVNCYGQEVEPMETTESKDLGSQTPQALTFNDGISEVKDEQTPGWTTAAGDMKFEYLLYGHREHIVCQACGKTFSDEARLRKHEKLHTADRPFVCEMCTKGFTTQAHLKEHLKIHTGYKPYSCEVCGKSFIRAPDLKKHERVHSNERPFACHMCDKAFKHKSHLKDHERRHRGEKPFVCSSCTKAFAKASDLKRHENNMHSERKQVTTANSIQSETEQLQAAAMAAEAEQQLETIACS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YB84</accession>
    <name>A0A8C2YB84_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">UBX domain-containing protein 2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">UBXN2A</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Acts to repress the ubiquitination and subsequent endoplasmic reticulum-associated degradation of CHRNA3 by the STUB1-VCP-UBXN2A complex in cortical neurons. Also acts to promote the translocation of CHRNA3 to the plasma membrane and subsequently increases plasma membrane acetylcholine-gated ion-channel activation. Plays a role in the inhibition of STUB1-mediated TP53 degradation, via its interaction with HSPA9 which acts to inhibit TP53 binding to HSPA9. Positively mediates the ubiquitination and proteosomal degradation of RICTOR, may thereby act as a negative regulator of the mTORC2 pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Part of a complex composed of STUB1/CHIP, VCP/p97, CHRNA3, and UBXN2A that modulates the ubiquitination and endoplasmic reticulum-associated degradation (ERAD) of CHRNA3. Within the complex UBXN2A acts as a scaffold protein required for the interaction of CHRNA3 with VCP/p97, this interaction also inhibits CHRNA3 ubiquitination by STUB1/CHIP and subsequently ERAD. Interacts (via SEP domain) with CHRNA3 and interacts (via UBX domain) with VCP/P97; these interactions are required for the interaction of CHRNA3 with the STUB1-VCP-UBXN2A complex. Interacts with HSPA9/MOT-2 (via SBD domain); the interaction inhibits HSPA9/MOT-2 interaction with and degradation of p53, thereby promotes p53 translocation to the nucleus. Interacts with RICTOR.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Dendrite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Perikaryon</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015715065.1">
        <property type="nucleotide sequence ID" value="XM_015859579.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015715066.1">
        <property type="nucleotide sequence ID" value="XM_015859580.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YB84"/>
    <dbReference type="Ensembl" id="ENSCJPT00005019941.1">
        <property type="protein sequence ID" value="ENSCJPP00005013927.1"/>
        <property type="gene ID" value="ENSCJPG00005011700.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107312288"/>
    <dbReference type="CTD" id="165324"/>
    <dbReference type="GeneTree" id="ENSGT00520000055567"/>
    <dbReference type="OrthoDB" id="25887at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043204">
        <property type="term" value="C:perikaryon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033130">
        <property type="term" value="F:acetylcholine receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990830">
        <property type="term" value="P:cellular response to leukemia inhibitory factor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061025">
        <property type="term" value="P:membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904293">
        <property type="term" value="P:negative regulation of ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031468">
        <property type="term" value="P:nuclear membrane reassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045732">
        <property type="term" value="P:positive regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031396">
        <property type="term" value="P:regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd17160">
        <property type="entry name" value="UBX_UBXN2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000164">
        <property type="entry name" value="UBX domain-containing protein 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.210:FF:000004">
        <property type="entry name" value="UBX domain-containing protein 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.210">
        <property type="entry name" value="SEP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036241">
        <property type="entry name" value="NSFL1C_SEP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012989">
        <property type="entry name" value="SEP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23333">
        <property type="entry name" value="UBX DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23333:SF16">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08059">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00553">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102848">
        <property type="entry name" value="NSFL1 (p97 ATPase) cofactor p47, SEP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51399">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="SEP" evidence="18">
        <location>
            <begin position="56"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="UBX" evidence="17">
        <location>
            <begin position="169"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="279"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00053310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00066082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00073763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005013927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="290" mass="33081" checksum="D81BFCA8E129774B" modified="2022-01-19" version="1">MDNIKTVREEWMCKSRTDDQILNGTEQNHDCFVDNLFEEAQKIGAICMSPTTVKKQVDVIIKLWKNGFTVNDGELRSYTDVGNQQFLDSVKKGELPFELQKVFEKEEVDVKVEDKKNELYLSSKKPIFHPFSGHGYRLGSATPRIVSKVREDHQGAADKRHLPIVPLNDLEPVTNIQIWLADGERIIQKFNISHRISHVRDFITKYQGSEGGVPFMLATSMPFRELQDETLTLKEAKLQNAVVVQRLRKTTEPFRLLVVKAPESDCKTAATPNGRLKNEQQNAVRSTSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YD85</accession>
    <name>A0A8C2YD85_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Retinoid isomerohydrolase</fullName>
            <ecNumber evidence="16">3.1.1.64</ecNumber>
            <ecNumber evidence="15">5.3.3.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Lutein isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Meso-zeaxanthin isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">RPE65</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>all-trans-retinyl hexadecanoate + H2O = 11-cis-retinol + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31775"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16302"/>
            <dbReference type="ChEBI" id="CHEBI:17616"/>
            <dbReference type="EC" id="3.1.1.64"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>an all-trans-retinyl ester + H2O = 11-cis-retinol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31771"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16302"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:63410"/>
            <dbReference type="EC" id="3.1.1.64"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>lutein = (3R,3'S)-zeaxanthin</text>
            <dbReference type="Rhea" id="RHEA:12729"/>
            <dbReference type="ChEBI" id="CHEBI:28838"/>
            <dbReference type="ChEBI" id="CHEBI:138919"/>
            <dbReference type="EC" id="5.3.3.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="21">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="21">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 22">Belongs to the carotenoid oxygenase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.64" evidence="16"/>
    <dbReference type="EC" id="5.3.3.22" evidence="15"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2YD85"/>
    <dbReference type="Ensembl" id="ENSCJPT00005024848.1">
        <property type="protein sequence ID" value="ENSCJPP00005017866.1"/>
        <property type="gene ID" value="ENSCJPG00005014519.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182913"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052885">
        <property type="term" value="F:all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052884">
        <property type="term" value="F:all-trans-retinyl-palmitate hydrolase, 11-cis retinol forming activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003834">
        <property type="term" value="F:beta-carotene 15,15'-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050251">
        <property type="term" value="F:retinol isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050908">
        <property type="term" value="P:detection of light stimulus involved in visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001895">
        <property type="term" value="P:retina homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042574">
        <property type="term" value="P:retinal metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901827">
        <property type="term" value="P:zeaxanthin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004294">
        <property type="entry name" value="Carotenoid_Oase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543">
        <property type="entry name" value="BETA-CAROTENE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543:SF57">
        <property type="entry name" value="RETINOID ISOMEROHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03055">
        <property type="entry name" value="RPE65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 21" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 21" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0564">Palmitate</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="12" id="KW-0844">Vision</keyword>
    <feature type="binding site" evidence="21">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="529"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00035787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00036037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00038936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00039141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00040820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00041301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00042900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR604294-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU003799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005017866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="535" mass="61233" checksum="3AA9A491E8D972FD" modified="2022-01-19" version="1">MYHLVEHPAGGYKKLFETVEELSSPVTAHVTGRIPTWLRGSLLRCGPGLFEVGAEPFYHLFDGQALLHKFDFKEGHVTYHRRFVRTDAYVRAMTEKRIVITEFGTYAYPDPCKNIFSRFFSYFKGVEVTDNALVNVYPVGEDYYACTETNFITKINPDTLETIKQVDLCKYVSVNGATAHPHVENDGTVYNIGNCFGKNFSLAYNIIRIPPLQADKEDPINKSEVVVQFPCSDRFKPSYVHSFGLTPNYIVFVETPVKINLLKFLSSWSLWGANYMDCFESNETMGVWLHVAEKKKGRLLNIKYRTSAFNLFHHINTFEDNGFLIVDLCTWKGWVFEFVYNYLYLANLRANWDEVKKQAEKAPQPEARRYVLPLRIDKADTGKNLVTLPYTTATATLRSDETVWLEPEVIFSGPRHAFEFPQINYKKYGGKPYTYTYGLGLNHFVPDRLCKLNVKTKETWVWQEPDSYPSEPIFVSHPDALEEDDGVVLSIVISPGSGPKPAYLLILNAKDMSEVARAEVEVNIPVTFHGLFKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YDE1</accession>
    <name>A0A8C2YDE1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Molybdenum cofactor sulfurase</fullName>
            <shortName evidence="4">MCS</shortName>
            <shortName evidence="4">MOS</shortName>
            <shortName evidence="4">MoCo sulfurase</shortName>
            <ecNumber evidence="4">2.8.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Molybdenum cofactor sulfurtransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">MOCOS</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:42636"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:82685"/>
            <dbReference type="EC" id="2.8.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. MOCOS subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.9" evidence="4"/>
    <dbReference type="RefSeq" id="XP_015709758.1">
        <property type="nucleotide sequence ID" value="XM_015854272.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YDE1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005025380.1">
        <property type="protein sequence ID" value="ENSCJPP00005018226.1"/>
        <property type="gene ID" value="ENSCJPG00005014849.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107309449"/>
    <dbReference type="KEGG" id="cjo:107309449"/>
    <dbReference type="CTD" id="55034"/>
    <dbReference type="GeneTree" id="ENSGT00940000157051"/>
    <dbReference type="OrthoDB" id="420046at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008265">
        <property type="term" value="F:molybdenum cofactor sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03050">
        <property type="entry name" value="MOCOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028886">
        <property type="entry name" value="MoCo_sulfurase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005303">
        <property type="entry name" value="MOCOS_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237:SF80">
        <property type="entry name" value="MOLYBDENUM COFACTOR SULFURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SULFURASE MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03476">
        <property type="entry name" value="MOSC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141673">
        <property type="entry name" value="MOSC N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="2 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MOSC" evidence="5">
        <location>
            <begin position="688"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="414"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005018226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="870" mass="97459" checksum="AC811EF7978C6C6F" modified="2022-01-19" version="1">MAEELLSFRAFQSSCPAGYEYGSELRGLREREFPRLRGITYLDHASSTLFPESLIKAFTDDLRNNVYGNPHSPNISSKLTYDTIEHVRYRILQHFHTTSEDYTVIFTSGCTAALKLVAEVFPWVPEGTEQPSSRFCYLTDNHTSVVGMRGITASMNVLSVPVKPKDKLLLEKDWLPDEEQNCMTPHLFSYPAQSNFSGTKYPLSWIRDIKSGKLCPVKIPGKWFVLLDAASYVSSSPLDLGVHQADFIPISFYKIFGFPTGLGALLVNNRIAPLLRKTYFGGGTAAAYLAGKDFYFPKKSIAERFEDGTVSFLDIIALKHGFDVLEKLTGGMEKIKQHTFALAHYTYTVLSTLKYANGAPVVRLYNDTNFSNADVQGPIINFNVLDESGEVIGFSQVEKMASLYNIHVRTGCFCNTGACQMHLGISDEDIQKNLQAGHVCGDDIDLIDGRPTGSVRISFGYMSSFEDAQTFLKFIIATRFSKSDAEIPFQSSATQLTTEPAPDDHSYFNDANKLSPRMHIADREHRNNPSGTERTVGWQPLESESEGLRAALSEVAVPNIKRGDKPITVTNIYLYPIKSCSAFEVTEWPVGNQGLLYDRNWMVVNQNGVCITQKQEPKLCLINPSIDLKQRIMVIQAEGMDPISVSIEENIGKETVIYESKVCSHRVKTYDCGERTAGWFSAFLGYPCRLIRQSPDRKNDMQHKNTKGLTCATSISLSLVNEAQYLLINAASILQLKEHVTARYRLKEPLEIEELIRRFRANIVISAPESFEEEEWAEISIGSLRFQVVGPCTRCQVICIDQQSGERNKEFLQSLSAARGKKTNFGIYLMNQPLRSSFPDILSVGSEVLPVLKENTEIQRPTFSEEKCSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YG14</accession>
    <name>A0A8C2YG14_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Pleckstrin and Sec7 domain containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">PSD</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Ruffle membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2YG14"/>
    <dbReference type="Ensembl" id="ENSCJPT00005032558.1">
        <property type="protein sequence ID" value="ENSCJPP00005023823.1"/>
        <property type="gene ID" value="ENSCJPG00005018780.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155061"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032154">
        <property type="term" value="C:cleavage furrow"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043197">
        <property type="term" value="C:dendritic spine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099092">
        <property type="term" value="C:postsynaptic density, intracellular component"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032587">
        <property type="term" value="C:ruffle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13295">
        <property type="entry name" value="PH_EFA6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1000.11:FF:000004">
        <property type="entry name" value="PH and SEC7 domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000054">
        <property type="entry name" value="PH and SEC7 domain-containing protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041681">
        <property type="entry name" value="PH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001605">
        <property type="entry name" value="PH_dom-spectrin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF334">
        <property type="entry name" value="PH AND SEC7 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15410">
        <property type="entry name" value="PH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00683">
        <property type="entry name" value="SPECTRINPH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="9">
        <location>
            <begin position="271"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="8">
        <location>
            <begin position="482"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="181"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="707"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="203"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="719"/>
            <end position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005023823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="753" mass="82363" checksum="7737B0A683FA57C3" modified="2022-01-19" version="1">MHGQKAQVCTSAHCCHQHSAPGMITGMHTVVSCSFDAAFVLTGGFQIFLMCRQSPGYSQQGTNPADSSAKNHQTEIASWFGACITAWALLTHCFRARSAAAALSPVPFLLGHSLSKDGMDSFSKHFESIMESHRAKGTSYTSLDSIDILSSPARTQGTFFTFDLPALTPEVQGQIRDSAKCHLRGSAGPGGGVSGDRGDSAAAGGGGEAGGDGAGGDAVRCGTARHGTARHGTGPVGKLTWCVPSHCSEHPMSQLVSDSDSEMDSMEQLALGSTDTLSNGHKADLEAAKRLAKRLYNLDGFKKADVARHLGKNNEFSKMVAGEYLKFFVFTGMSLDQALRSFLKELALMGETQERERVLAHFSQRYYECNPNAISSEDGAHTLTCALMLLNTDLHGHNIGKRMSCSDFIGNLEGLNGGTDFPKELLKALYGSIKNEKLQWAIDEEELRKSLSELADPKPKSIKRISSCSNPFLDFSQDSSIATYKHGLLVRKIHADPDCKKTPRGKRGWKPFHAILKGMILYLQKEEYKPGKALAEEELKNAISIHHSLATRASDYSKRPNVFYLRTADWRVFLFQAQNSEQMHSWITRINVVAAMFSAPPFPAAIGSQKKFSRPLLPSSCTRLSQDEQVKSHETKFKTMSAELLEHRSSLPDKKVKGKEYEELKQKEEYLEFEKSRYGTYAMLLRAKLKAGSEDLAAFESTLFDAAGGEDDGLKKSRSSPSLNAEPSSTGTKVKRNISERASRQPPGHPQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YH75</accession>
    <name>A0A8C2YH75_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA replication licensing factor MCM6</fullName>
            <ecNumber evidence="12">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">MCM6</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="12"/>
    <dbReference type="RefSeq" id="XP_015724368.1">
        <property type="nucleotide sequence ID" value="XM_015868882.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YH75"/>
    <dbReference type="Ensembl" id="ENSCJPT00005035639.1">
        <property type="protein sequence ID" value="ENSCJPP00005026320.1"/>
        <property type="gene ID" value="ENSCJPG00005020470.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107316873"/>
    <dbReference type="KEGG" id="cjo:107316873"/>
    <dbReference type="CTD" id="4175"/>
    <dbReference type="GeneTree" id="ENSGT01150000286966"/>
    <dbReference type="OrthoDB" id="1744952at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071162">
        <property type="term" value="C:CMG complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:hydrolase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:identical protein binding"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:single-stranded 3'-5' DNA helicase activity"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902969">
        <property type="term" value="P:mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17757">
        <property type="entry name" value="MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.870:FF:000001">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000091">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1640.10:FF:000004">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000115">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.870">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008049">
        <property type="entry name" value="MCM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041024">
        <property type="entry name" value="Mcm6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
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    </dbReference>
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        <property type="entry name" value="MCM_dom"/>
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        <property type="entry name" value="MCM_lid"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
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        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF73">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM6"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00493">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
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    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18263">
        <property type="entry name" value="WHD_MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01662">
        <property type="entry name" value="MCMPROTEIN6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="14">
        <location>
            <begin position="347"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="681"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU368064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="825" mass="93427" checksum="EC11874A9B554116" modified="2022-01-19" version="1">MDLAVAAGGAGAVQQHQQLRDEVAEKCQKLFQDFLEEFQNSDGEVKYLRDAEELIRPERNTLTVSFVDLEQFNQQLSTTVQEEFYRVYPYLCRAVRTFARDHGNIPANKDFYVAFQDLPTRHKIRELTSAKIGSLMRISGQVVRTHPVHPELVSGTFLCLDCQTVIKDVEQQFKYTQPNICRNPVCANRRRFLLDTNKSRFVDFQKVRIQETQAELPRGSIPRSVEVILRAEAVESAQAGDKCDFTGSLIVVPDVAQLSTPGVRAETGSRVSGTDGYEAEGIRGLRALGVRELSYKLVFLACYVAPTNPRFGGKELRDEEQTAESIKNQMTVKEWEKVFEMSQDKNLYHNLCTSLFPTIHGNDEVKRGVLLMLFGGVPKTTSEGTSLRGDINVCVVGDPSTAKSQFLRHVDEFSPRAVYTSGKASSAAGLTAAVVKDEESHEFVIEAGALMLADNGVCCIDEFDKMDMRDQVAIHEAMEQQTISITKAGVKATLNARTSILAAANPVGGRYDRSKSLKQNINLSAPIMSRFDLFFILVDECNEVTDYAIARRIVDLHARVEESVDRVYSLDDIRRYLLFARQFKPKISKESEDFIVEQYKRLRQRDSSGVTKSSWRITVRQLESMIRLSEAMARMHCCDEVHPKHVKEAFRLLNKSIIRVETPDINLDQDDEQEMEYQEEQDGVNGEAEAPAGVNGLVNGTSGHSEDMNKDAAPKASLRLGFSEYRRISNLLVLHLRKAEEEEDDSSLKKSELINWYLKEIESEIESEEELINKKKIIEKVIYRLTRYDHILIELSQSGLRGSKEEETFDEDPYLVVNPNYMLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YH97</accession>
    <name>A0A8C2YH97_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Coiled-coil domain containing 42</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">CCDC42</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015735002.1">
        <property type="nucleotide sequence ID" value="XM_015879516.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YH97"/>
    <dbReference type="Ensembl" id="ENSCJPT00005035792.1">
        <property type="protein sequence ID" value="ENSCJPP00005026441.1"/>
        <property type="gene ID" value="ENSCJPG00005020556.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107321980"/>
    <dbReference type="KEGG" id="cjo:107321980"/>
    <dbReference type="CTD" id="146849"/>
    <dbReference type="GeneTree" id="ENSGT00940000153110"/>
    <dbReference type="OrthoDB" id="2134857at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007286">
        <property type="term" value="P:spermatid development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051147">
        <property type="entry name" value="CFAP_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025252">
        <property type="entry name" value="DUF4200"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21683:SF8">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21683">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 42 LIKE-2-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13863">
        <property type="entry name" value="DUF4200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4200" evidence="3">
        <location>
            <begin position="46"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="120"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="180"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005026441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="312" mass="37069" checksum="E838419ADE8A5F2D" modified="2022-01-19" version="1">MAEAMATVDNEDLSDYFSMQYRQNLLPLLKKLKLTEEDSLSPFIRLQEKKKEAQEMQRILEEKEEDFRVRIENLTCRWKELWAKEAKLKAHMKKSERTLKDNDKMRIQALKKAGKERELMIQKENELLSARKELEELKNKHQKLSVGVQNYSIFGTYLEDVVKISQFEEIQAIMWRYRMLVRMRKALLQAERGLREAKEQAEEFSQCAEDGSLQYKDDLDQLELRYQQATKDILTWETRWADIQKTTAKKTQELGAIKMAIFSLFQHVSEQVKGSLNVPVDDSYTQLNVIQQFIQDLMDILMEVRRKGIQYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2026-01-28" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q6PRV2</accession>
    <name>Q6PRV2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein S100</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">S100 calcium-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MRP</name>
        <name evidence="8" type="synonym">S100A12</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2006" name="Oncogene" volume="25" first="4043" last="4055">
            <title>Cooperative cell transformation by Myc/Mil(Raf) involves induction of AP-1 and activation of genes implicated in cell motility and metastasis.</title>
            <authorList>
                <person name="Hartl M."/>
                <person name="Karagiannidis A.I."/>
                <person name="Bister K."/>
            </authorList>
            <dbReference type="PubMed" id="16491116"/>
            <dbReference type="DOI" id="10.1038/sj.onc.1209441"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the S-100 family.</text>
    </comment>
    <dbReference type="EMBL" id="AY583752">
        <property type="protein sequence ID" value="AAT01286.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6PRV2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005024077.1">
        <property type="protein sequence ID" value="ENSCJPP00005017248.1"/>
        <property type="gene ID" value="ENSCJPG00005014112.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107324457"/>
    <dbReference type="KEGG" id="cjo:107324457"/>
    <dbReference type="GeneTree" id="ENSGT00940000162189"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0070062">
        <property type="term" value="C:extracellular exosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0048306">
        <property type="term" value="F:calcium-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0050786">
        <property type="term" value="F:RAGE receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0061844">
        <property type="term" value="P:antimicrobial humoral immune response mediated by antimicrobial peptide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0050832">
        <property type="term" value="P:defense response to fungus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0043542">
        <property type="term" value="P:endothelial cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0031640">
        <property type="term" value="P:killing of cells of another organism"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0043123">
        <property type="term" value="P:positive regulation of canonical NF-kappaB signal transduction"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="CDD" id="cd05030">
        <property type="entry name" value="calgranulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001751">
        <property type="entry name" value="S100/CaBP7/8-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013787">
        <property type="entry name" value="S100_Ca-bd_sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11639:SF77">
        <property type="entry name" value="PROTEIN S100-A12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11639">
        <property type="entry name" value="S100 CALCIUM-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF01023">
        <property type="entry name" value="S_100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01394">
        <property type="entry name" value="S_100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS00303">
        <property type="entry name" value="S100_CABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="4 5" id="KW-0106">Calcium</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="59"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAT01286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005017248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="119" mass="14012" checksum="00DFB09902DC5CFB" modified="2004-07-05" version="1">MSKGCQTQGPLSELEKAMDTIIDVFHQYSRREGDNDTLTKKELKLLIEKQLANYLKHVKNQVSIDQIFKDLDGNKDQQLSFGEVMLLIIRVIIATHEHLHFCEDHQHQQQHQHQHQHNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SP35</accession>
    <name>A0A8C2SP35_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Centrosomal P4.1-associated protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Centromere protein J</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Centrosome assembly and centriole elongation protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">CENPJ</name>
        <name evidence="15" type="synonym">CPAP</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="7">Forms homodimers. Associates with microtubules plus ends; binds to beta-tubulin subunits exposed on microtubule outer surface at its distal tip; also associates with microtubule lattice. Associated with the gamma-tubulin complex. Interacts with the head domain of EPB41. Interacts with LYST. Interacts with CEP152 (via C-terminus). Interacts with STIL. Forms a complex with STIL and SASS6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TCP10 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SP35"/>
    <dbReference type="Ensembl" id="ENSCJPT00005002725.1">
        <property type="protein sequence ID" value="ENSCJPP00005001618.1"/>
        <property type="gene ID" value="ENSCJPG00005001660.1"/>
    </dbReference>
    <dbReference type="KEGG" id="cjo:107308344"/>
    <dbReference type="GeneTree" id="ENSGT00530000063927"/>
    <dbReference type="OrthoDB" id="10252174at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120099">
        <property type="term" value="C:procentriole replication complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030954">
        <property type="term" value="P:astral microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061511">
        <property type="term" value="P:centriole elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044458">
        <property type="term" value="P:motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903724">
        <property type="term" value="P:positive regulation of centriole elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904951">
        <property type="term" value="P:positive regulation of establishment of protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900087">
        <property type="term" value="P:positive regulation of G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902857">
        <property type="term" value="P:positive regulation of non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046427">
        <property type="term" value="P:positive regulation of receptor signaling pathway via JAK-STAT"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007224">
        <property type="term" value="P:smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.450.20:FF:000001">
        <property type="entry name" value="Centromere protein J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.450.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009852">
        <property type="entry name" value="CENPJ_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047002">
        <property type="entry name" value="Tcp10_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026581">
        <property type="entry name" value="TCP10L/CENPJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058029">
        <property type="entry name" value="Tubulin-bd_CENPJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10331:SF23">
        <property type="entry name" value="CENTROMERE PROTEIN J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10331">
        <property type="entry name" value="T COMPLEX PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07202">
        <property type="entry name" value="Tcp10_C"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25779">
        <property type="entry name" value="Tubulin-bind_CPAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CENPJ tubulin-binding region" evidence="14">
        <location>
            <begin position="212"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Centromere protein J C-terminal" evidence="13">
        <location>
            <begin position="1059"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="domain" description="Centromere protein J C-terminal" evidence="13">
        <location>
            <begin position="1130"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="domain" description="Centromere protein J C-terminal" evidence="13">
        <location>
            <begin position="1166"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="domain" description="Centromere protein J C-terminal" evidence="13">
        <location>
            <begin position="1204"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="57"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="305"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="490"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="574"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="613"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="698"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="955"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="124"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="222"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="791"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="877"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="326"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="493"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="584"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="613"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="706"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1006"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1021"/>
            <end position="1036"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00064598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00069791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00081769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00083148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF25779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005001618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1247" mass="140746" checksum="DA0882569D01934F" modified="2022-01-19" version="1">MPTVEDLSSEQNFLAHWMSSSSRAGVLLDPRFTGLKINTENLLPGPENIAAFPGEAQHLSDSGSVSEDSLSEEQLLQSGSSCALQQNSTETDFPATACNVGSSKADFGHSELDGQNKSNCSDPLLQKLEQLKELQQQKQEQLKKQQMEQLKRLMEEQQKLLSMVSGQTAVPGKSTWCPEQKMEKLMETEDPPMDPFCAELSESTEKDLWVTNAEERPIKAAIQEKKQTFEEFVEEQMQIEEQRLKQKQKLQEMYGSAIQKPVIKQPFLKRGEGLARFTNAKSKITKSGENILKPPQRTLEDRNVRVDRSQMQKKSLPSGKELVSGSPLTPRQKNNQPDKAKCCPLQKTLVLRNHNGKNSLPLETRMQPGKNLDGQIKVSFSSEINNRIENKENVVDFTKTSTGSKIRNKLPDIENPQVADAFSNSNCSVSLPVKDSELSFEVSFQNKLENWEKEKEKENLELDEFLFLEQAADEISFSSNSSFVQRILDRDQQTSQGRRMSSTPIKAKPQQVKEPAAELIIKKKGECVAAGNRNDKAVNHTVSNSETASRLKDPLNKADSVMFSVSSTTAAPNLKSTQWSVNEDKDEENGDSTTDSEQEFETTLKYENEDVKTSFVSHRESDPELLDYGSSATDISKESKNRGANLDLSGKDSSAQSNQKVRRASDHQRSMACVNRNKFEFDDERTWSDLDEDYAHDDLPEKYSKMPSQNDFFSKNNTPFPDKALKRKVASKKGEELSKQSAVDGDSNGPPSNLMVKLFPSLKPKQKTGCHPEHEIKSSVEQESGGATVPSQILREKLIELEMEIERFRAENTILTKLREEREHALASIRKEIADFQQQKAQELAEIEEYRKKEMKKLQKERKVFEKYTIEARAIPDKKERDEIQALKQQMAELQEDFKRKEAKWSTTHRRLKDQIDALVNENMELKEEVKIMEKFRLEAWKKVEAVGSKKKVENSGMTLKRTEPVCPQNRGLKSETGSLLPPTQKCGKTNGKNYPEAKGKLLRGPASAPASAPAKDNSKSETVTTLEDSSKTFMDTSPDEALVSVPPGPAFTDSEEIQKEIAYPDGRVEKVLKNGCHLIFLPNGTWKKVGSDGKTVTITFFNGDVKQIMPDQTVIYYYADAKTTHTTYPDGLEVLQFSNGQIEKHYPDGKKEITFPDQTIKSLFTDGQEESIFPDGTIVRIQRDGSKTIEFNNGQRELHTSQFKRREYPDGTVKTVYSNGHQETKYVSGRIRVKDKDGNILMDTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SP75</accession>
    <name>A0A8C2SP75_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phenazine biosynthesis like protein domain containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">PBLD</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PhzF family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SP75"/>
    <dbReference type="Ensembl" id="ENSCJPT00005002894.1">
        <property type="protein sequence ID" value="ENSCJPP00005001711.1"/>
        <property type="gene ID" value="ENSCJPG00005001759.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000017595"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030277">
        <property type="term" value="P:maintenance of gastrointestinal epithelium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030512">
        <property type="term" value="P:negative regulation of transforming growth factor beta receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.310.10:FF:000013">
        <property type="entry name" value="Phenazine biosynthesis-like domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.10">
        <property type="entry name" value="Diaminopimelate Epimerase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003719">
        <property type="entry name" value="Phenazine_PhzF-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00654">
        <property type="entry name" value="PhzF_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13774">
        <property type="entry name" value="PHENAZINE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13774:SF17">
        <property type="entry name" value="PHENAZINE BIOSYNTHESIS-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02567">
        <property type="entry name" value="PhzC-PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016184">
        <property type="entry name" value="PhzC_PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54506">
        <property type="entry name" value="Diaminopimelate epimerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="3">
        <location>
            <position position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR016184-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005001711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="268" mass="29957" checksum="BA53B318058FD16E" modified="2022-01-19" version="1">MGLSCHCQDLDEDLHQRIATEMNLSETAFIRKLRPTDDFTTSSRFGLRWFTPANEVPLCGHATLASAAVLFHIKKNPNSVLTFVTLSGELKTRQEKDHIVLDLPLYSTYPQALQEVEELIKAATGDMKVQDLRYSPDTKKLLVRLSDAYERSVLEELQVGAQSFLSAEKTGKVKGLILTLKGKSNGKDKGHDFYSRYFAPWYGVLEDPVTGSAHAVLSSYWSEQLGKKEMLAFQCSRRGGELKISLRDNGRVEIAGQFSIVLKGNLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SPB3</accession>
    <name>A0A8C2SPB3_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SPB3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005001488.1">
        <property type="protein sequence ID" value="ENSCJPP00005000846.1"/>
        <property type="gene ID" value="ENSCJPG00005000929.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005000846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="103" mass="11685" checksum="A8E404FBAECC1B2E" modified="2022-01-19" version="1">MSLSKQGTKEYNRTLQVKLWKTQDFPHLILTCGSTHFRAWTSLLIDKLFLSYSIIDDKGLCCTQKAPHSFLITLIPLSILACRYPQEQAVGSVHGFSLNMLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SPD5</accession>
    <name>A0A8C2SPD5_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Aminopeptidase</fullName>
            <ecNumber evidence="18">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">NPEPPS</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>Release of an N-terminal amino acid, preferentially alanine, from a wide range of peptides, amides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16 18">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="16 18">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="18"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2SPD5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005001540.1">
        <property type="protein sequence ID" value="ENSCJPP00005000870.1"/>
        <property type="gene ID" value="ENSCJPG00005000955.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155246"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016285">
        <property type="term" value="F:alanyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071456">
        <property type="term" value="P:cellular response to hypoxia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000001">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.50.20:FF:000004">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000002">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1910:FF:000002">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF174">
        <property type="entry name" value="PUROMYCIN-SENSITIVE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 18" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 16 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 18" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="12" id="KW-0944">Nitration</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 18" id="KW-0645">Protease</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 16 18" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="21">
        <location>
            <begin position="63"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="19">
        <location>
            <begin position="259"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="20">
        <location>
            <begin position="557"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="354"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="17">
        <location>
            <position position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU364040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005000870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="899" mass="101449" checksum="FF7161585F107FA8" modified="2022-01-19" version="1">MGFRYSGSEKDKSSRWKIFLFFASSKHVVMWEFIDEVEVGLPTSLGCPPPCVLLFLMLMMFLLQVKNATNQIVMNCADIDIITASYAPEGDEEVHATGFNYQNEDEKVTLSFPSTLQKGTGTLKIDFVGELNDKMKGFYRSKYTTPTGDTRYAAVTQFEATDARRAFPCWDEPAIKATFDISLVVPKDRVALSNMNVIDRKPYPDDENLVEVKFARTPIMSTYLVAFVVGEYDFVETRSLDGVLVRVYTPVGKAEQGKFALEVAAKTLPFYKDYFNVPYPLPKIDLIAIADFAAGAMENWGLVTYRETALLIDPKNSCSSSRQWVALVVGHELAHQWFGNLVTMEWWTHLWLNEGFASWIEYLCVDHCFPEYDIWTQFVSADYTRAQELDALDNSHPIEVSVGHPSEVDEIFDAISYSKGASVIRMLHDYIGDEDFRKGMNLYLTKFLQKNAATEDLWESLEKASGKPIAAVMNTWTKQMGFPLIYVEAEQQEDDKVLKLVQKKFCASGPYAGEDFPMWMVPISICTSDDPTSAKMQVLMDKPELTLVLKDVKPDQWVKLNLGTVGFYRTQYSPDMLESLIPAIKDLSLPPVDRLGLQNDLFSLARAGIISTVEVLKVMEAFVNEPNYTVWSDLSCNLEILSTLLSHTDFYEEIQVFVKDVFSPIGERLGWDPKPGEGHLDALLRGLVLGKLGKAGHKATLEEARRRFKDHVEGKNILSADLRSPVYVTILKHGDSATLDTMLKLHKQADMQEEKNRIERVLGAISQPELIQKVLTFALSEEVRPQDTVSVIGGVAGGSKQGRKAAWKFVRDNWEELYNRYQGGFLISRLIKLTVDGFANDKMAAEVKAFFESHPAPSAERTVQQCCENILLNAAWLKRDSEDIHQFFLHRKGPPPTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SPP8</accession>
    <name>A0A8C2SPP8_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sorting nexin-27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">SNX27</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in the retrograde transport from endosome to plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins. Following internalization, endocytosed transmembrane proteins are delivered to early endosomes and recycled to the plasma membrane instead of being degraded in lysosomes. SNX27 specifically binds and directs sorting of a subset of transmembrane proteins containing a PDZ-binding motif at the C-terminus: following interaction with target transmembrane proteins, associates with the retromer complex, preventing entry into the lysosomal pathway, and promotes retromer-tubule based plasma membrane recycling. SNX27 also binds with the WASH complex. Interacts with membranes containing phosphatidylinositol-3-phosphate (PtdIns(3P)). May participate in establishment of natural killer cell polarity. Recruits CYTIP to early endosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Early endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SPP8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005000413.1">
        <property type="protein sequence ID" value="ENSCJPP00005000207.1"/>
        <property type="gene ID" value="ENSCJPG00005000271.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183212"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001772">
        <property type="term" value="C:immunological synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098842">
        <property type="term" value="C:postsynaptic early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098837">
        <property type="term" value="C:postsynaptic recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098685">
        <property type="term" value="C:Schaffer collateral - CA1 synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071203">
        <property type="term" value="C:WASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008333">
        <property type="term" value="P:endosome to lysosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099072">
        <property type="term" value="P:regulation of postsynaptic membrane neurotransmitter receptor levels"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090128">
        <property type="term" value="P:regulation of synapse maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13338">
        <property type="entry name" value="FERM-like_C_SNX27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01777">
        <property type="entry name" value="FERM_F1_SNX27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23070">
        <property type="entry name" value="PDZ_SNX27-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06886">
        <property type="entry name" value="PX_SNX27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.60:FF:000002">
        <property type="entry name" value="sorting nexin-27 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000061">
        <property type="entry name" value="sorting nexin-27 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000075">
        <property type="entry name" value="sorting nexin-27 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000003">
        <property type="entry name" value="sorting nexin-27 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037827">
        <property type="entry name" value="SNX27_FERM-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037833">
        <property type="entry name" value="SNX27_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037835">
        <property type="entry name" value="SNX27_RA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12431">
        <property type="entry name" value="SORTING NEXIN 17 AND 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12431:SF19">
        <property type="entry name" value="SORTING NEXIN-27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PDZ" evidence="13">
        <location>
            <begin position="31"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="14">
        <location>
            <begin position="149"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="15">
        <location>
            <begin position="261"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005000207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="586" mass="66280" checksum="92B1F60DD320FBCF" modified="2022-01-19" version="1">MADEEGEGPPRSAAAPQRNGGDEGAPGGPRVVRIVKSESGYGFNVRGQVSEGGQLRSINGELYAPLQHVSAVLGGGAADRAGVRKGDRILEVNGVNVEGATHKQVVDLIRAGEKELILTVLSVPPHEADNLDPSDDSLGQSFYDYTEKQAVPISIPTYKHVEQNGEKFVVYNVYMAGRQLCSKRYREFAILHQNLKREFANFTFPRLPGKWPFSLSEQQLDARRRGLEEYLEKVCSIRVIGESDIMQEFLSESDENYNGVSDVELRVALPDITTVTVRVKKNSTTDQVYQAVAAKVGMDSITANYFALFEVINHSFVRKLAPNEFPHKLYVQNYTSAVPGTCLTIRKWLFTTEEEALLNDSDLVATYFFHKAVDDVKKGYIKAEEKSYQLQKLCEQRKMVMYLNMLRTCEGYNEIIFPHCSCDSRRKGHVITAISIKHFKLHACTEEGQLENQVIAFEWDEMQRWDTDEEGMAFCFEYARGEKKPRWVKIFTPYFNYMHECFERVFCELKWRKEVEEEATDKDNQNCSTDTVCSKVTALQHPPGALRLLLLPQLRSCCTRSSAPFLCHGCRLCCCAQWSVAVPGCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SR64</accession>
    <name>A0A8C2SR64_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Eukaryotic translation initiation factor 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">EIF5</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon. In this complex, acts as a GTPase-activating protein, by promoting GTP hydrolysis by eIF2G (EIF2S3). During scanning, interacts with both EIF1 (via its C-terminal domain (CTD)) and EIF1A (via its NTD). This interaction with EIF1A contributes to the maintenance of EIF1 within the open 43S PIC. When start codon is recognized, EIF5, via its NTD, induces eIF2G (EIF2S3) to hydrolyze the GTP. Start codon recognition also induces a conformational change of the PIC to a closed state. This change increases the affinity of EIF5-CTD for EIF2-beta (EIF2S2), which allows the release, by an indirect mechanism, of EIF1 from the PIC. Finally, EIF5 stabilizes the PIC in its closed conformation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the 43S pre-initiation complex (43S PIC), which is composed of the 40S ribosomal subunit, EIF1, eIF1A (EIF1AX), eIF3 complex, EIF5 and eIF2-GTP-initiator tRNA complex (eIF2 ternary complex). Interacts with eIF1A (EIF1AX) during scanning. Interacts through its C-terminal domain (CTD) with EIF1 or with eIF2-beta (EIF2S2) (mutually exclusive) through a common binding site. Interacts through its C-terminal domain (CTD) with the CTD of EIF5B. Interacts with FMR1 isoform 6; this interaction occurs in a RNA-dependent manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2-beta/eIF-5 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015721145.1">
        <property type="nucleotide sequence ID" value="XM_015865659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SR64"/>
    <dbReference type="Ensembl" id="ENSCJPT00005004790.1">
        <property type="protein sequence ID" value="ENSCJPP00005002576.1"/>
        <property type="gene ID" value="ENSCJPG00005002874.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107315351"/>
    <dbReference type="KEGG" id="cjo:107315351"/>
    <dbReference type="CTD" id="1983"/>
    <dbReference type="GeneTree" id="ENSGT00390000016478"/>
    <dbReference type="OrthoDB" id="10250831at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071074">
        <property type="term" value="F:eukaryotic initiation factor eIF2 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005092">
        <property type="term" value="F:GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042255">
        <property type="term" value="P:ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd11561">
        <property type="entry name" value="W2_eIF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000018">
        <property type="entry name" value="eukaryotic translation initiation factor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.350:FF:000002">
        <property type="entry name" value="Eukaryotic translation initiation factor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.170:FF:000002">
        <property type="entry name" value="Eukaryotic translation initiation factor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045196">
        <property type="entry name" value="IF2/IF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002735">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016189">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016190">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003307">
        <property type="entry name" value="W2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001:SF7">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01873">
        <property type="entry name" value="eIF-5_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02020">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00653">
        <property type="entry name" value="eIF2B_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00515">
        <property type="entry name" value="eIF5C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100966">
        <property type="entry name" value="Translation initiation factor 2 beta, aIF2beta, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75689">
        <property type="entry name" value="Zinc-binding domain of translation initiation factor 2 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51363">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="W2" evidence="16">
        <location>
            <begin position="231"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="142"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="153"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="193"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00053999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00065967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005002576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="430" mass="49092" checksum="31F6491A23B580C8" modified="2022-01-19" version="1">MSVNVNRSVSDQFYRYKMPRLIAKVEGKGNGIKTVIVNMVDVAKALNRPPTYPTKFFGCELGAQTQFDVKNDRYIVNGSHEANKLQDMLDGFIKKFVLCPECENPETDLHVNPKKQTIGNSCKACGYRGMLDTNHKLCTFILKNPPESGDTGTGKKEKEKKNRKGKDKENGSVSSNDTPPPPPPEEITPPQVVEEEDDDDWGEDTTEEAQRRRMDEISDHAKNLTLSEDLERTVEERVNILFDFVKKKKEEGVIDSSDKDIVAEAERLDVKAMGPLVLTEVLFDEKIREQIRKYRRHFLRFCHNNKKAQRYLLHGFECVVAMHQTQLISKIPHILKEMYDADLLEEEVILGWAEKASKKYVSKELAKEIRVKAEPFIKWLKEAEEESSGNEEEDEDENIEVVYSTTASVPKVETVKPANNKDDDIDIDAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SS48</accession>
    <name>A0A8C2SS48_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Programmed cell death 1 ligand 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">CD274</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015704470.1">
        <property type="nucleotide sequence ID" value="XM_015848984.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032297226.1">
        <property type="nucleotide sequence ID" value="XM_032441335.1"/>
    </dbReference>
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    <dbReference type="Ensembl" id="ENSCJPT00005005400.1">
        <property type="protein sequence ID" value="ENSCJPP00005002972.1"/>
        <property type="gene ID" value="ENSCJPG00005003230.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005005403.1">
        <property type="protein sequence ID" value="ENSCJPP00005002975.1"/>
        <property type="gene ID" value="ENSCJPG00005003230.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107306120"/>
    <dbReference type="KEGG" id="cjo:107306120"/>
    <dbReference type="CTD" id="29126"/>
    <dbReference type="GeneTree" id="ENSGT00940000161373"/>
    <dbReference type="OrthoDB" id="8680608at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome Z"/>
    </dbReference>
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        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071222">
        <property type="term" value="P:cellular response to lipopolysaccharide"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:immune response"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:negative regulation of T cell proliferation"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of T cell proliferation"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:T cell costimulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Butyrophilin subfamily 1 member A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001912">
        <property type="entry name" value="CD274 molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053896">
        <property type="entry name" value="BTN3A2-like_Ig-C"/>
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    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051713">
        <property type="entry name" value="T-cell_Activation_Regulation"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25466:SF3">
        <property type="entry name" value="PROGRAMMED CELL DEATH 1 LIGAND 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25466">
        <property type="entry name" value="T-LYMPHOCYTE ACTIVATION ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22705">
        <property type="entry name" value="C2-set_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="IG_LIKE"/>
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    </dbReference>
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    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
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    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
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    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
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    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
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    <feature type="chain" id="PRO_5044679372" evidence="12">
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            <begin position="247"/>
            <end position="267"/>
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    </feature>
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        <location>
            <begin position="36"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="13">
        <location>
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            <end position="229"/>
        </location>
    </feature>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005002972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="317" mass="36541" checksum="957DFE06435DA4B3" modified="2022-01-19" version="1">MMEKLLFLHIFLFCWRSLNALFTVEAPKSLYTAELGSNVTMECIFPVNGKLKFRDLSVIWEKKDDVRKDVYVLLKGKEDSGSQHSDFQGRIKLLKENLDLGQSLLQISNVKLRDAGLYHCLIEYGGADYKTINLKVQAPYRSITQEVISTGDKEWKLTCQSKGFPKAEVMWQNGECQDLTNKANTSYETGSDQLYRVTSTLTIKNRTRENFRCIFWNKETQENTSANLYILDSTDDVLWTESRLRAFVWPILIVSVLVGSVSITVCIRKAKANKDCRTRMAKPSINITKLLKDKDVHDCRDPSFEDQELKYMQIEKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SS99</accession>
    <name>A0A8C2SS99_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SS99"/>
    <dbReference type="Ensembl" id="ENSCJPT00005003774.1">
        <property type="protein sequence ID" value="ENSCJPP00005002107.1"/>
        <property type="gene ID" value="ENSCJPG00005002271.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01040000244587"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10900">
        <property type="entry name" value="PAC-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038389">
        <property type="entry name" value="PSMG2_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005002107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="107" mass="11446" checksum="9F8AFD9A9190025E" modified="2022-01-19" version="1">MAPIAPFGFAGILVPCNGDSGPNSTGFTLLMPQVSAGNVGHLEVDLVISILFVPKVDYFHTEAVKYQAEEWFLAGLLRLWVPAGPDCSAPSPAFYSYSFLSTSSSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SSF6</accession>
    <name>A0A8C2SSF6_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SSF6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005003883.1">
        <property type="protein sequence ID" value="ENSCJPP00005002179.1"/>
        <property type="gene ID" value="ENSCJPG00005002336.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155548"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47202:SF2">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47202">
        <property type="entry name" value="HISTIDINE-RICH GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="270"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="369"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="405"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="435"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="4">
        <location>
            <begin position="44"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005002179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="671" mass="73887" checksum="6E92FC7A8181DC42" modified="2022-01-19" version="1">MVDYHSAGQPYSYGGNGPGTNGDYMAQEDDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTHIDNIDEDFRDGLKLMLLLEVISGQTATHCIASHCIVLYCIVLHGMALYCIVLHCIVLHGIAWHCIVLHCIVLHCIVLHCTALHGMALHCIASHGIVLHCIASHCMALHGIALYCIALHCTVLHCIALYGIALYCIVWHGIAWHCIVLYMYCIVLHCIVLHCIVLHCIALHGIASHCIALHGIALYCIALHCIVLHCIAWHGIAWHGIALYCFALHCIVLHCMALHCIAWHCMALHCIALYCIAWHGIVWHCMAWHCIALHGIAWHCIALHGIALYCIVLHCIALHCIVLHCIALHGMALHGIALHCIVLHCMALHCIALHCIALHCIALHCIALHCIAWHCIAWHCMALHCIVLHCIVLHCIALHCMTLHGIVLHCIALYCIALYCIAWHGMALHGMALHCIAWHGIASHCIASHGMAWHCIAWHCIALHGIALHCIASHCMAWHCVALYCIALHGLPWDGGSMQPQGSPNAAPMQPWVHYCSGSNAALAPMQPWVQYSPGSNAAVAPMQPRFHPPIFPPPGERLPKPERGKMRVHKINNVNKALDYIASKGVKLVSIGAEGESGLQGMGQGRECRQCRAGNAGQVMQGKQCRAGNAGQAMQAMQGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SSJ9</accession>
    <name>A0A8C2SSJ9_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein uL15/eL18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the large ribosomal subunit.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SSJ9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005002356.1">
        <property type="protein sequence ID" value="ENSCJPP00005001407.1"/>
        <property type="gene ID" value="ENSCJPG00005001439.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000012976"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000039">
        <property type="entry name" value="Ribosomal_eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10934">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10934:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17135">
        <property type="entry name" value="Ribosomal_L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="5">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005001407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="123" mass="13862" checksum="446CC2B05D652F0F" modified="2022-01-19" version="1">MGERSGVDIRHNRDRKVRRREPKSQDIYLRLLVKLYRFLARRTNSAFNKVVLKRLFMSRTNRPPMAGLNMGGALGVFGLNGFISADGTCAPGGAWQFLLIPLQAPLQLPKYPPNTPQLPPHIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2ST84</accession>
    <name>A0A8C2ST84_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exosome complex component RRP45</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Exosome component 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">EXOSC9</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015717399.1">
        <property type="nucleotide sequence ID" value="XM_015861913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2ST84"/>
    <dbReference type="Ensembl" id="ENSCJPT00005006114.1">
        <property type="protein sequence ID" value="ENSCJPP00005003461.1"/>
        <property type="gene ID" value="ENSCJPG00005003629.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107313564"/>
    <dbReference type="KEGG" id="cjo:107313564"/>
    <dbReference type="CTD" id="5393"/>
    <dbReference type="GeneTree" id="ENSGT00950000183130"/>
    <dbReference type="OrthoDB" id="10264038at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030307">
        <property type="term" value="P:positive regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11368">
        <property type="entry name" value="RNase_PH_RRP45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.70:FF:000005">
        <property type="entry name" value="Exosome complex component RRP45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033100">
        <property type="entry name" value="Rrp45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF14">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0271">Exosome</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="12">
        <location>
            <begin position="32"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="13">
        <location>
            <begin position="189"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="349"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="349"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="428"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005003461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="440" mass="49380" checksum="09DE413046A8A71A" modified="2022-01-19" version="1">MKETPLSNCERRFLLRAIQERKRLDGRQCYDYRNVRISFGPERGCCVVELGKTRVLGQVSCELVPPKPNRATEGILFCNLELSPMAAPGFEPGRQSELLVKVNRLIERCLRNSKCIDTESLCVVAGEKVWQIRVDLHLLNHDGNIIDAASIAGIVALCHFRRPDVSVQGKEITVYSPEERDPVPLSIHHMPICVSFAFFQQGTYLLVDPNEREERVMDGLLVIAMNKHQEICTIQSSGGIMLLKDQVLRCSKITAVKVAEITELIQKALENDQKVRKEGGKFGFAESISNQKITAFKMDSAAVDTNNVEEQAEEIITKADPPSEVFAKPILHTPGTAQIGEGIENTWGELEESEREEAAEEEGESSATAFECQRAETEDTSMMSEAKDEPIVLSDSEEEEVVILEPQEVPKKTRPQTNLKQENTSKKAFNKKRRKKRASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SW17</accession>
    <name>A0A8C2SW17_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Keratin 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">KRT12</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the intermediate filament family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SW17"/>
    <dbReference type="Ensembl" id="ENSCJPT00005007739.1">
        <property type="protein sequence ID" value="ENSCJPP00005004667.1"/>
        <property type="gene ID" value="ENSCJPG00005004575.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159382"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005882">
        <property type="term" value="C:intermediate filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061303">
        <property type="term" value="P:cornea development in camera-type eye"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030855">
        <property type="term" value="P:epithelial cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045109">
        <property type="term" value="P:intermediate filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002009">
        <property type="term" value="P:morphogenesis of an epithelium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1160:FF:000002">
        <property type="entry name" value="Type I keratin 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000002">
        <property type="entry name" value="Type I keratin KA11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.500:FF:000001">
        <property type="entry name" value="Type II keratin 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.500">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1160">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018039">
        <property type="entry name" value="IF_conserved"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039008">
        <property type="entry name" value="IF_rod_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002957">
        <property type="entry name" value="Keratin_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23239">
        <property type="entry name" value="INTERMEDIATE FILAMENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23239:SF369">
        <property type="entry name" value="KERATIN, TYPE I CYTOSKELETAL 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00038">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01248">
        <property type="entry name" value="TYPE1KERATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01391">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64593">
        <property type="entry name" value="Intermediate filament protein, coiled coil region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00226">
        <property type="entry name" value="IF_ROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51842">
        <property type="entry name" value="IF_ROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 4" id="KW-0403">Intermediate filament</keyword>
    <keyword evidence="1" id="KW-0416">Keratin</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF rod" evidence="7">
        <location>
            <begin position="114"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="430"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="118"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="215"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="325"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005004667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="456" mass="48352" checksum="34F178182DAF0EB2" modified="2022-01-19" version="1">MSGSSAGGSFGGSGLGFGGGSVGGFGAASVLGSGFSGSFGNSVGSGFGGGFVSGSGGGYGSGSGSGFGGGLGSGFGSGSGSIFGGGFGSGAAAGFGGGFGIGGGGDGGLLSGSKKETMQNLNDRLAAYLDKVRSLEDANTELERKIREWYEKNGPGAAVPGSGNDYSKYYPIIEDLRNKIINATIDNARIILQVDNARLAADDFRLKYDNEVALRQSVEADINGLRRVLDELTLTRADLEMQIESLNEELAYLKKNHEEWMKHSAVGQVSVEMDAAPGIDLTKLLNDMRGQYEVIAEQNRKEAEAWFNEKSGELKREISTNTEQLQSGKSEITDLKRTLQNLEIELQSQLAMKKSLEDTLAETEGGYCAQLSQMQLQIGNLESQLLQVRADMERQSAEYQQLLDIKSRLEMEIETYRRLLDGEFVAPPLPSEAGHQRGAWEGDGSGPAPRGWRGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SWD3</accession>
    <name>A0A8C2SWD3_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycine cleavage system P protein</fullName>
            <ecNumber evidence="8">1.4.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">GLDC</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[glycine-cleavage complex H protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:24304"/>
            <dbReference type="Rhea" id="RHEA-COMP:10494"/>
            <dbReference type="Rhea" id="RHEA-COMP:10495"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="1.4.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer. The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GcvP family.</text>
    </comment>
    <dbReference type="EC" id="1.4.4.2" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2SWD3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005005456.1">
        <property type="protein sequence ID" value="ENSCJPP00005003016.1"/>
        <property type="gene ID" value="ENSCJPG00005003257.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000017970"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome Z"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016594">
        <property type="term" value="F:glycine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990830">
        <property type="term" value="P:cellular response to leukemia inhibitory factor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00613">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000025">
        <property type="entry name" value="Glycine cleavage system P protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000153">
        <property type="entry name" value="Glycine dehydrogenase (decarboxylating)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000005">
        <property type="entry name" value="Glycine dehydrogenase (decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000007">
        <property type="entry name" value="glycine dehydrogenase (Decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00711">
        <property type="entry name" value="GcvP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001597">
        <property type="entry name" value="ArAA_b-elim_lyase/Thr_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003437">
        <property type="entry name" value="GcvP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049316">
        <property type="entry name" value="GDC-P_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049315">
        <property type="entry name" value="GDC-P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020581">
        <property type="entry name" value="GDC_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00461">
        <property type="entry name" value="gcvP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001696">
        <property type="entry name" value="PRK00451.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003346">
        <property type="entry name" value="PRK04366.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773:SF1">
        <property type="entry name" value="GLYCINE DEHYDROGENASE (DECARBOXYLATING), MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773">
        <property type="entry name" value="GLYCINE DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01212">
        <property type="entry name" value="Beta_elim_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21478">
        <property type="entry name" value="GcvP2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02347">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Glycine cleavage system P-protein N-terminal" evidence="11">
        <location>
            <begin position="168"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="Aromatic amino acid beta-eliminating lyase/threonine aldolase" evidence="10">
        <location>
            <begin position="689"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine dehydrogenase C-terminal" evidence="12">
        <location>
            <begin position="932"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="857"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR603437-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF21478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005003016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1123" mass="124096" checksum="12D3DF659B05DAC1" modified="2022-01-19" version="1">MTISGAAVVQPCHPLSDAHKARGGTMFPSRFHSLMPGQRNAPPPPHPPWSRSGVRAGRVGPAGVVGIRWRRGGASTAPPLLPIGAVGGGRAAPPSAATKRGARRWRGGVGGAMQSCGRWWGRLAARGAPRHLRPAAGGPRRQQQQRWGGGDAARCIEQLLPRHDDFCRRHIGPREREKREMLRAVGVQSVEELMDKTIPASIRLRRPLRMDDHVGENEILETLYNIASKNKIWRSYIGMGYYNCSVPQPIARNLLENAGWVTQYTPYQPEVSQGRLESLLNYQTMVCDITGMDMANASLLDEGTAAAEAMQLCHRHNKRRKFYIDARCHPQTIAVVQTRANYTGVITELKLPHEMDFSGKDVSGVLFQYPDTEGKVEDFSELVERAHQNGTLACCATDLLALCILKPPGEFGVDVVLGSSQRFGVPLCYGGPHAAFFAVKENLVRMMPGRMVGVTRDANGKEVYRLALQTREQHIRRDKATSNICTAQALLANMAAMYGVYHGSDGLKDIARRVHNATLILAEGLRRAGHKLHHDLFFDTLTVTCGCSVKEVLDRAALRKINFRIYSDGRLGVSLDETVNEKDLDDILWIFGCESSAELVAEGMGEETKGILSTPFKRTSKFLTHQVFNSYHSETNIVRYMKRLENKDISLVHSMIPLGSCTMKLNSSAELAPISWKEFANIHPFVPLDQAQGYQQLFKDLEKDLCEITGYDKISFQPNSGAQGEYAGLAAIKAYLNAKGERHRSVCLIPRSAHGTNPASAQMAGMKIQPIEVDKNGSIDISHLKAMVDKHKENLAAIMITYPSTNGVFEEEIGDVCDLIHKHGGQVYLDGANMNAQVGLCRPGDYGSDVSHLNLHKTFCIPHGGGGPGMGPIGVKKHLAPYLPTHPVIKIQTDKDACPLGTVSAAPWGSSAILPISWVYIKTMGAKGLKHASEIAILNANYMAKRLEKHYKILFRGVRGYVAHEFILDTRPFKKTANIEAVDLAKRLQDYGFHAPTMSWPVAGTLMIEPTESEDKAELDRFCDAMISIRQEIAEIEEGRMDPQVNPLKMSPHTLNCVTSSKWDRPYSREVAAFPLPFVKPESKFWPTIARIDDIYGDQHLVCTCPPMEAYESPFSEQKRASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SXD5</accession>
    <name>A0A8C2SXD5_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Macrophage mannose receptor 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC107309034</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="Ensembl" id="ENSCJPT00005007431.1">
        <property type="protein sequence ID" value="ENSCJPP00005004437.1"/>
        <property type="gene ID" value="ENSCJPG00005004211.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01050000244842"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23407">
        <property type="entry name" value="beta-trefoil_Ricin_MRC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="CDD" id="cd00062">
        <property type="entry name" value="FN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.10.10:FF:000001">
        <property type="entry name" value="Fibronectin 1a isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000032">
        <property type="entry name" value="macrophage mannose receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.100.10:FF:000016">
        <property type="entry name" value="macrophage mannose receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.100.10:FF:000023">
        <property type="entry name" value="Macrophage mannose receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.100.10:FF:000031">
        <property type="entry name" value="macrophage mannose receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.100.10:FF:000022">
        <property type="entry name" value="Mannose receptor C-type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.100.10:FF:000025">
        <property type="entry name" value="Mannose receptor C-type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.100.10:FF:000030">
        <property type="entry name" value="Mannose receptor C-type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.100.10:FF:000027">
        <property type="entry name" value="Mannose receptor, C type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.10.10">
        <property type="entry name" value="Fibronectin, type II, collagen-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000562">
        <property type="entry name" value="FN_type2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036943">
        <property type="entry name" value="FN_type2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24562">
        <property type="entry name" value="CysR_MRC2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00040">
        <property type="entry name" value="fn2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00013">
        <property type="entry name" value="FNTYPEII"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00059">
        <property type="entry name" value="FN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00023">
        <property type="entry name" value="FN2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51092">
        <property type="entry name" value="FN2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 14" id="KW-0732">Signal</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034752556" evidence="14">
        <location>
            <begin position="19"/>
            <end position="1411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1379"/>
            <end position="1400"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-II" evidence="16">
        <location>
            <begin position="163"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="15">
        <location>
            <begin position="223"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="15">
        <location>
            <begin position="363"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="15">
        <location>
            <begin position="505"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="15">
        <location>
            <begin position="649"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="15">
        <location>
            <begin position="793"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="15">
        <location>
            <begin position="939"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="15">
        <location>
            <begin position="1095"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="15">
        <location>
            <begin position="1235"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1352"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1361"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="168"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="182"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005004437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1411" mass="161444" checksum="C8FE9F5C6E169455" modified="2022-01-19" version="1">MRFSGFLFGLTLIHGALQLEDTEIFLIYNKVSKLCLQASIAQSVRTATCHQDNESQKFRWITDHQLMSVRLNLCLGVPLKEDEVAVTLFPCNQTSDLQWWECRNESLLAIQGEDLFFSPGKEEHDNVVLKKRPSPKNNWKIYGAMDVLCSQRYEETFTLLGNAFGAPCVFPFMYKKQWYAECTAAGRSDGWLWCSTTADYDTDQRYGFCPVKDRDTTWTTDLLRNAHYQINSESALTWHQARKSCQQQNAELLSITDIHEQMYLKELTESTDSALWIGLNRLDLKSGWEWIGGTPFHYLNWAPGSPSPESGKLCVVLNPETKAKWQNWECDQKLGYICKKRNFTLIPPGDIGPIACPDGWTSYIDHCYKIFRESKGWQEALTSCQNEGSHLVSIQHLEEHSFIVSGLGYKPTDKLWIGLNDHKFQMFFEWSDGTPVTYTKWHLGEPSSTNNRPEDCVMIKGQDGYFADSDCGKKAGYICKRKPIPQIAGEKENTDVGCKKGWVRYGTYCYFIGHVPATFSEANNTCEGQKGYLLTVESRYEQAYLTSLVGLRPDKYFWLGLSDMEDQGTFRWSSGEEVSFTHWNAAMPGSKRGCVAMRTGTAAGLWDVLDCESKQKYICKQWAVGATAPPLSSAAPKPTCPEGWISNDHASSCYKSFCRSDIKKKSWIEARDFCRQIGGDLATINNEEEIKMISSENSYCRFERVWIGIYSLNPDEGFAWSDGSPVMYTDWSDHPRSSEGHMFCGLAYYRQWLLSLCEEQHNWVCQIKKGVVPKPEPIDTYEYKTTADGWVIYEDKLYYISQEQVSMEEAREFCRMNSADLAVINSNSERNFIQRALIKNDKYRSESGQYFIGLKLSLDKKFSWIDGTPITYVAWAPNEPNFANNEEHCVVMFSKQGLWNDVNCGTTNRFVCERHNSSINSTLASLFPPGGCPESWLFFKNKCFKIFASNTTRKLAWHDAREVCIDLGGNLASVPNEQVQAFVYYHLEDATTNVWIGMNDINRESKFFWADGSTVSYTNWVEGAPETKQSYFDYYEFESLDDNAVETDCVFMTKLDGKWKDDSCDNEKGYICQMNSLAEQFNSPATNPSPDFVPYGDSSYLIVLSEMQWEEARKNCQEQHAELASILDAYIHSFLWIQMQKYGKPVWIGLNSNITRSYYKWTDNWKTRFTKWAAEEPKKKNACVYLDLDGTWKTAPCKETYFSVCKKSNVVAPTEPAQLPGECPEAADLQAWIPYHGHCYYIEASAATSWAQASLKCTHLGATLVSVENEDESDFLIHTIQLLGNKVGGFWIGLYRNVDDQWLWLDNAAMDFVNWEEKESNEKHHCVEMTAPSGYWDNADCSSEKGFICKKTKVEPSGSPPKKDKQRNEETHPPVHPSVWPLFFLAILSLLGAGVLIYFYKRKRQNQLSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SXY0</accession>
    <name>A0A8C2SXY0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transcription initiation factor TFIID subunit 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">TBP-associated factor 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">TAF3</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription. TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C. TAF3 forms the TFIID-A module together with TAF5 and TBP. Required in complex with TBPL2 for the differentiation of myoblasts into myocytes. The TAF3-TBPL2 complex replaces TFIID at specific promoters at an early stage in the differentiation process.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TAF3 family.</text>
    </comment>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    <keyword evidence="6" id="KW-0804">Transcription</keyword>
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    <keyword evidence="4" id="KW-0862">Zinc</keyword>
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    <feature type="compositionally biased region" description="Polar residues" evidence="13">
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SY96</accession>
    <name>A0A8C2SY96_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SCAN box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="gene ID" value="ENSCJPG00005004658.1"/>
    </dbReference>
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        <property type="component" value="Chromosome LGE64"/>
    </dbReference>
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        <property type="entry name" value="zinc finger protein 263 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4020.10">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SCAN-C2H2_zinc_finger"/>
    </dbReference>
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        <property type="entry name" value="SCAN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038269">
        <property type="entry name" value="SCAN_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45935">
        <property type="entry name" value="PROTEIN ZBED8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45935:SF15">
        <property type="entry name" value="SCAN BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02023">
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        <property type="entry name" value="Retrovirus capsid dimerization domain-like"/>
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="41"/>
            <end position="113"/>
        </location>
    </feature>
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            <begin position="1"/>
            <end position="31"/>
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            <begin position="1"/>
            <end position="11"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50804"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="140" mass="17049" checksum="0578AC832E5005B6" modified="2022-01-19" version="1">MVPLPPTPPYQSSPLRGLDPTPMDPHRILSPLMGPNMEQRRLRFRQFRYQEASGPRAACWTLKELSRLWLRPETRSKEQILELLVLEQFLSILPEQIQSWVWVRHPQSCAQAVGWRRVIPKGGRNRCEWRWRWRWRWRWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SYE5</accession>
    <name>A0A8C2SYE5_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sulfotransferase</fullName>
            <ecNumber evidence="5">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC107325879</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="5"/>
    <dbReference type="RefSeq" id="XP_015742624.1">
        <property type="nucleotide sequence ID" value="XM_015887138.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SYE5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005007987.1">
        <property type="protein sequence ID" value="ENSCJPP00005004858.1"/>
        <property type="gene ID" value="ENSCJPG00005004708.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107325879"/>
    <dbReference type="GeneTree" id="ENSGT00940000159269"/>
    <dbReference type="OrthoDB" id="536948at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome LGE64"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000433">
        <property type="entry name" value="Estrogen sulfotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="6">
        <location>
            <begin position="34"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005004858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="296" mass="34613" checksum="E9FED9663011C6D0" modified="2022-01-19" version="1">MPVHYVMYKGIKFPPAYNSVHSLSFAHNEFLVRDDDIFNITYPKSGTVWMTEILSLIRSHGHPSWNQTVLNSDRMPWFSTHLGLEAALSYPSPRLLTCHLPRHIFPKSFSHSTAKVIYTLQDPRDVVVSYFYFCKMCNSYEDPVSFEQFLRDFLNGELPHGSWFEHVRGWMEMKDRENFFFITYEELKQDLQGSMRRLCHFLGQNLDDNAISSVVQNASFTAMRQNPMCSSILLPADIMDQTKGQFLRKGICGDWKNHFTVAQSETFNRIYLEKMQGLDMAFPWDRDWDPDQTEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SYQ8</accession>
    <name>A0A8C2SYQ8_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">C-C chemokine receptor type 5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC107309356</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015709562.1">
        <property type="nucleotide sequence ID" value="XM_015854076.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SYQ8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005007295.1">
        <property type="protein sequence ID" value="ENSCJPP00005004356.1"/>
        <property type="gene ID" value="ENSCJPG00005004321.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107309356"/>
    <dbReference type="KEGG" id="cjo:107309356"/>
    <dbReference type="GeneTree" id="ENSGT01020000230359"/>
    <dbReference type="OrthoDB" id="9876908at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019957">
        <property type="term" value="F:C-C chemokine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016493">
        <property type="term" value="F:C-C chemokine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060326">
        <property type="term" value="P:cell chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007204">
        <property type="term" value="P:positive regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090026">
        <property type="term" value="P:positive regulation of monocyte chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000026">
        <property type="entry name" value="C-C chemokine receptor type 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050119">
        <property type="entry name" value="CCR1-9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002236">
        <property type="entry name" value="Chemokine_CCR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000355">
        <property type="entry name" value="Chemokine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10489:SF686">
        <property type="entry name" value="C-C CHEMOKINE RECEPTOR TYPE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10489">
        <property type="entry name" value="CELL ADHESION MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00657">
        <property type="entry name" value="CCCHEMOKINER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01106">
        <property type="entry name" value="CHEMOKINER1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="90"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005004356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="394" mass="44979" checksum="56E957F56221D191" modified="2022-01-19" version="1">MGGPLIWKGALPLPLEPEPTLLTCCSPTAIAASSSDQHTMENYTTDLDDMSTTTFDYGDTAPCMGTEEKHFAANFLPPLYSLVVIFGFIGNILVVLILVKYKRLKSMTDIYLLNLAISDLLFVFSLPFWAYYAAHDWIFGDALCRILSGIYLLGFYSGIFFIILLTIDRYLAIVHAVFAIKARTVTYGIFTSTVTWAVAIFASVPGIVFHKTQTEHAQYTCSFHYPPDSLINWKQSYILKMNILGLLIPMIIMIFCYSQILKTLLRCRNEKKQKAVRLIFVIMIFYFIFWTPFHVTSFVHTFQTSFFSPDCDSQSRLEKTIQVTETISMIHCCINPVIYAFVGEKFRKYLYTFFRKHVAAHLCKKCPSFYREKLERVSSTFTASTAENDISTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SZC1</accession>
    <name>A0A8C2SZC1_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Synaptotagmin binding cytoplasmic RNA interacting protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">SYNCRIP</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Microsome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SZC1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005007214.1">
        <property type="protein sequence ID" value="ENSCJPP00005004279.1"/>
        <property type="gene ID" value="ENSCJPG00005004288.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153511"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21066">
        <property type="entry name" value="NURR_hnRNPQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12489">
        <property type="entry name" value="RRM2_hnRNPQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12495">
        <property type="entry name" value="RRM3_hnRNPQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000023">
        <property type="entry name" value="Heterogeneous nuclear ribonucleoprotein q isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000024">
        <property type="entry name" value="Heterogeneous nuclear ribonucleoprotein q isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000027">
        <property type="entry name" value="Heterogeneous nuclear ribonucleoprotein q isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041337">
        <property type="entry name" value="hnRNP_Q_AcD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006535">
        <property type="entry name" value="HnRNP_R/Q_splicing_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034548">
        <property type="entry name" value="hnRNPQ_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01648">
        <property type="entry name" value="hnRNP-R-Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21245">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18360">
        <property type="entry name" value="hnRNP_Q_AcD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="11" id="KW-0492">Microsome</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="14" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="16" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="12 17" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="RRM" evidence="19">
        <location>
            <begin position="493"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="19">
        <location>
            <begin position="574"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="19">
        <location>
            <begin position="669"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="192"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="242"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="828"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="209"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="18">
        <location>
            <begin position="253"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="327"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="835"/>
            <end position="855"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005004279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="893" mass="98612" checksum="20B4272EDCB4AE67" modified="2022-01-19" version="1">MRGRPRVGSRCPHEVGRGAAPPCWRLGAVLRAGRQPHKAPLSPPFVCVALSLSQSHSLVRVGRDLRDHRVQPPGFEPCVAERHFDHLRHRGIRTGVSGVAKCLRPRPSPSCHLRTVGTAAHPLVSLPPRSSVARRFVTAFIVCSMRAVPAQVCRSCGRRRLPRPAVLQPGASRRLSRLLLLLPCRQRASPRVREPRALPPCREGAAPRWGREGTAGRERAQPVGRGEAITLAELPGRPRVWGCASARGASSSLPPPGSPPRPPEPSGRGWGWCQQRRERSSGRHFTPAPAHCPDTPRERRRGAAPQHAEPPAAPRAPSHGVSPPQPQISGNMATEHVNGNGTEEPMDTSAAVTHSEHFQTLLDAGLPQKVAEKLDEIYVAGLVAHSDLDERAIDALREFNEEGALSVLQQFKDSDLSHVQNKSAFLCGVMKTYRQREKQGTKVADSSKGPDEAKIKALLERTGYTLDVTTGQRKYGGPPPDTVYSGQQPSVGTEIFVGKIPRDLFEDELVPLFEKAGPIWDLRLMMDPLTGLNRGYAFVTFCTKEAAQEAVKLYNNHEIRSGKHIGVCISVANNRLFVGSIPKSKTKEQIVEEFSKVTEGLTDVILYHQPDDKKKNRGFCFLEYEDHKTAAQARRRLMSGKVKVWGNVVTVEWADPIEDPDPEVMAKVKVLFVRNLANTVTEEILEKAFSQFGKLERVKKLKDYAFIHFDERDGAVKAMEEMNGKDLEGENIEIVFAKPPDQKRKERKAQRQAAKNQMYDDYYYYGPPHMPPPTRGRGRGGRGGYGYPPDYYGYEDYYDYYGYDYHNYRGGYEDPYYGYEDFQVGARGRGGRGARGAAPSRGRGAAPPRGRAGYAQRGGPGSARGVRGARGGAQQQRGRGQGKGVEAGPDLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T1B9</accession>
    <name>A0A8C2T1B9_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acrosin</fullName>
            <ecNumber evidence="2">3.4.21.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC107306626</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.</text>
            <dbReference type="EC" id="3.4.21.10"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.4.21.10" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2T1B9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005010120.1">
        <property type="protein sequence ID" value="ENSCJPP00005006420.1"/>
        <property type="gene ID" value="ENSCJPG00005006003.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162777"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome Z"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007340">
        <property type="term" value="P:acrosome reaction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000003">
        <property type="entry name" value="Transmembrane serine protease 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF8">
        <property type="entry name" value="ACROSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S1" evidence="9">
        <location>
            <begin position="123"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="431" mass="47127" checksum="0EE34A278CEE236A" modified="2022-01-19" version="1">MHILPSDTHGAAHLPHHPPLTSWITQLRGQLSTHGPPLGWHSPWNRRTDGAVTSALRATAASVATKPGVLGCRAMMIVPRGAMVPLLPLVVLLAACRPGYGYTGACNTCGTRPMAYQYGASRVVGGTDASPGAWPWIVSLQSTWYVGTGHICGGSLITPQWVLTAAHCFDHASPDTPWHVVIGGHNLKQLGPEAVVRSVVRVIPHEYYHRDSMANDIALLELDQPVQCSYYIELACVPDNSVRVSELTDCYVAGWGHMGMRSLQEYVEPYRVLQEARVHLIDLNICNSSHWYAGAIHSHNICAGYPQGGIDTCQGDSGGPLMCKDKTADYFWLIGVTSWGKGCGRAQQPGVYASTQYFRNWILVQMGLLPAEAPTSTPYPVYVTTSYQRPKPTYSTPIRPCPFPRQKLLDFFNMLQELLQSLGGKKARLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T1F1</accession>
    <name>A0A8C2T1F1_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">F-box protein 34</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FBXO34</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015721323.1">
        <property type="nucleotide sequence ID" value="XM_015865837.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015721324.1">
        <property type="nucleotide sequence ID" value="XM_015865838.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015721325.1">
        <property type="nucleotide sequence ID" value="XM_015865839.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015721326.1">
        <property type="nucleotide sequence ID" value="XM_015865840.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015721328.1">
        <property type="nucleotide sequence ID" value="XM_015865842.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T1F1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005010518.1">
        <property type="protein sequence ID" value="ENSCJPP00005006726.1"/>
        <property type="gene ID" value="ENSCJPG00005006231.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005010519.1">
        <property type="protein sequence ID" value="ENSCJPP00005006727.1"/>
        <property type="gene ID" value="ENSCJPG00005006231.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005010520.1">
        <property type="protein sequence ID" value="ENSCJPP00005006728.1"/>
        <property type="gene ID" value="ENSCJPG00005006231.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107315446"/>
    <dbReference type="KEGG" id="cjo:107315446"/>
    <dbReference type="CTD" id="55030"/>
    <dbReference type="GeneTree" id="ENSGT00530000064222"/>
    <dbReference type="OrthoDB" id="10052741at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd22176">
        <property type="entry name" value="F-box_FBXO34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039594">
        <property type="entry name" value="FBXO34/46"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16271:SF11">
        <property type="entry name" value="F-BOX ONLY PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16271">
        <property type="entry name" value="F-BOX ONLY PROTEIN 34/46 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="604"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="520"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="527"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="745" mass="81352" checksum="93FC00BAB0DDF602" modified="2022-01-19" version="1">MKSSCRAGLHREPLNSASSTFHQVKRVSGMHLKPYLKLQRKERSEISQDSLRGPPMSQRSTQDKYTNNCTKLRVFPKPPLVTPSRKLLGIIYPNTMCNMSGKGPADGLSAREKKNVLSATIHQGEEGEGPLDVWAVVKPGNTKEKIAFFAAQQCSGSNRLGSMKLKSTWDIDGRTVKRRKKTVDLKKAKIQLERMREVNARCSQPEPFACGIEHCSVHYVNDSGEGVFPGRSLSVIEMVAFLEQRASALLVDCAKTCTSASTARLSAPSKGALPSSDPFSAAGPCEVHERGGCGSSEQQQSEPVRVLDMVAKLESECLRRQSERDGGSLSRNNSFRRNVGRVLLASSTQHGAEPGRASVGSVGRGEELGAAGAGCGVRCGDAGLWDGAASAPQPFPPGLEAHVGNAGSGLAHAVLAIAAGRGDAERRVEPPRALPALCPAVAGVPVDSLPSKSATVDCTSKEAVILSKQSLHPARKEPLCISISVTKTEKGCQKEKLPPSSLSEDPLPGRLFFLQAEQNATHAPQPLRERTQEKPGEGVQNEDEDALESDKSCVRTNVTPEPSALSVPPPEGALQVLDASCLKRQVSHDFLETRFKIQQLLEPQQYMAFLPHHIIVKIFGLLPTRSLVALKCTCYYFKFIIEYYNIRPADSRWVRDPRYREDPCKQCKKKYVKGDVSLCRWHPKPYCQALPYGPGYWMCCHRSQKGIPGCKLGLHDNHWVPACHSFNRALHKKTRGAGAEGEEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T1Y7</accession>
    <name>A0A8C2T1Y7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Metal cation symporter ZIP14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Solute carrier family 39 member 14</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">Zrt- and Irt-like protein 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="29" type="primary">SLC39A14</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="29" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>Cd(2+)(out) + 2 hydrogencarbonate(out) = Cd(2+)(in) + 2 hydrogencarbonate(in)</text>
            <dbReference type="Rhea" id="RHEA:62256"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:48775"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:62257"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>Fe(2+)(out) + 2 hydrogencarbonate(out) = Fe(2+)(in) + 2 hydrogencarbonate(in)</text>
            <dbReference type="Rhea" id="RHEA:62368"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:62369"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>Mn(2+)(out) + 2 hydrogencarbonate(out) = Mn(2+)(in) + 2 hydrogencarbonate(in)</text>
            <dbReference type="Rhea" id="RHEA:62260"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:62261"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>Zn(2+)(out) + 2 hydrogencarbonate(out) = Zn(2+)(in) + 2 hydrogencarbonate(in)</text>
            <dbReference type="Rhea" id="RHEA:62252"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:62253"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Apical cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Basolateral cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Early endosome membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lysosome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ZIP transporter (TC 2.A.5) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T1Y7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005010063.1">
        <property type="protein sequence ID" value="ENSCJPP00005006376.1"/>
        <property type="gene ID" value="ENSCJPG00005005978.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157986"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140410">
        <property type="term" value="F:monoatomic cation:bicarbonate symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071578">
        <property type="term" value="P:zinc ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050799">
        <property type="entry name" value="ZIP_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12191:SF5">
        <property type="entry name" value="METAL CATION SYMPORTER ZIP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12191">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0967">Endosome</keyword>
    <keyword evidence="16" id="KW-0406">Ion transport</keyword>
    <keyword evidence="18" id="KW-0458">Lysosome</keyword>
    <keyword evidence="17 27" id="KW-0472">Membrane</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 28" id="KW-0732">Signal</keyword>
    <keyword evidence="10 27" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 27" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="14" id="KW-0864">Zinc transport</keyword>
    <feature type="signal peptide" evidence="28">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034192043" description="Metal cation symporter ZIP14" evidence="28">
        <location>
            <begin position="16"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="520"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="546"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="374"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="745"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="386"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="26">
        <location>
            <begin position="754"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="784"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="806"/>
            <end position="815"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00035822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00036412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00040176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00042543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00042974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00047497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00048071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="842" mass="89513" checksum="A96E0F15AE0721EC" modified="2022-01-19" version="1">MQCCAVLCCVMQCSAMQCCAVQCSAVLCNAVLCCAVQCSAVQCCAVQCSAALCSAALCNAVLCSAVQCCAVQCCAVLCCAVQCSAVQCSAVLCSAVQCCAMQCCAVQCSAVQCNAVQCSAVQCCAPPAALTAMTSPSMLPLLLLLSMHRVPAGAEEPQPALSAASFVQDLLQRYGGGRALSLEQLKLLLTRLDVGLGRSNGSEPRNNVSRCFSSAELFAVHNLSRSSVLGAAELSAFCPAVLQQLESAACAAGNLQDQEQQQQETEESRPSSAEVWGYGFLCVTVISLCSLVGASVVPFMKKTFYKRLLLYFIALAIGTLYSNALFQLIPEAFGFNPQEDYYVSKSAVVFGGFYLFFFTEKILKMLLKQKDPHHHGHSHYSTEPLPSRKDREEGVTEKLQNGDLDHMIPHVTNEMECKSPPGDEKVVVGSLSVQDLQASQSACYWLKEVRYSDIGTLAWMITLSDGLHNFIDGLAIGASFTVSVFQGISTSVAILCEEFPHELGDFVILLNAGMSIRQALFFNFMSACCCYVGLAFGIVAGSHFSANWIFALAGGMFLYIALADMVRARTGTRCWEQDPVLGSGPRVGIRTQRWEQDPVFGSGPSVWIRTRCWEQDPGLGSGPGVGSRTQCLDQDPVLGAGPSAGIRTQCWEQDPVLGQGPSVGSRTQCWDQDPVLGAGPGVGSRTQCWEQDPGLGAGPGVGIRTQCWEQDPGLGAGPSVGIRTQCWDQDPVLGSGPRVGIRTQCWDQDPVLGPGPGAGSGGCAAGRAEPLTAPCSVPSVPSVPRDERGEPGGRAERQRAHHLRHPERGAADGLHHHGAAHHVLGADPDRVDPARALHQVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T3P0</accession>
    <name>A0A8C2T3P0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="3">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">UBE2R2</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="3"/>
    <dbReference type="RefSeq" id="XP_015703758.1">
        <property type="nucleotide sequence ID" value="XM_015848272.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T3P0"/>
    <dbReference type="SMR" id="A0A8C2T3P0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005009356.1">
        <property type="protein sequence ID" value="ENSCJPP00005005845.1"/>
        <property type="gene ID" value="ENSCJPG00005005534.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107305747"/>
    <dbReference type="KEGG" id="cjo:107305747"/>
    <dbReference type="CTD" id="54926"/>
    <dbReference type="GeneTree" id="ENSGT00940000158828"/>
    <dbReference type="OrthoDB" id="19692at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome Z"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070936">
        <property type="term" value="P:protein K48-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd23803">
        <property type="entry name" value="UBCc_UBE2R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000009">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 R2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="12">
        <location>
            <begin position="8"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="194"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="206"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="9">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005005845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="238" mass="27178" checksum="135EC9B28A1F1095" modified="2022-01-19" version="1">MAQQQMSSSQKALMLELKSLQEEPVEGFRITLVDESDLYNWEVAIFGPPNTLYEGGYFKAHIKFPIDYPYSPPTFRFLTKMWHPNIYENGDVCISILHPPVDDPQSGELPSERWNPTQNVRTILLSVISLLNEPNTFSPANVDASVMFRKWRDSKGKDKEYAEIIRKQVLATKAEAEKDGVKVPTTLAEYCIKTKVPSNDNSSDLLYDDLYDDDIDDEDEEEEDADCYDDDDSGNEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T3P5</accession>
    <name>A0A8C2T3P5_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Adenylyltransferase and sulfurtransferase MOCS3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Molybdenum cofactor synthesis protein 3</fullName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="11">Molybdopterin-synthase adenylyltransferase</fullName>
                <ecNumber evidence="11">2.7.7.80</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="11">Adenylyltransferase MOCS3</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="11">Sulfur carrier protein MOCS2A adenylyltransferase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="11">Molybdopterin-synthase sulfurtransferase</fullName>
                <ecNumber evidence="11">2.8.1.11</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="11">Sulfurtransferase MOCS3</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="11">Sulfur carrier protein MOCS2A sulfurtransferase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="11 14" type="primary">MOCS3</name>
        <name evidence="11" type="synonym">UBA4</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1 and MOCS2A. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; NFS1 probably acting as a sulfur donor for thiocarboxylation reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly + ATP + H(+) = [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly-AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:43616"/>
            <dbReference type="Rhea" id="RHEA-COMP:12159"/>
            <dbReference type="Rhea" id="RHEA-COMP:12202"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:90618"/>
            <dbReference type="ChEBI" id="CHEBI:90778"/>
            <dbReference type="EC" id="2.7.7.80"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly-AMP + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] + AH2 = [molybdopterin-synthase sulfur-carrier protein]-C-terminal-Gly-aminoethanethioate + L-cysteinyl-[cysteine desulfurase] + A + AMP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48612"/>
            <dbReference type="Rhea" id="RHEA-COMP:12157"/>
            <dbReference type="Rhea" id="RHEA-COMP:12158"/>
            <dbReference type="Rhea" id="RHEA-COMP:12159"/>
            <dbReference type="Rhea" id="RHEA-COMP:19907"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:90618"/>
            <dbReference type="ChEBI" id="CHEBI:232372"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.8.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">In the N-terminal section; belongs to the HesA/MoeB/ThiF family. UBA4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.80" evidence="11"/>
    <dbReference type="EC" id="2.8.1.11" evidence="11"/>
    <dbReference type="RefSeq" id="XP_015737541.2">
        <property type="nucleotide sequence ID" value="XM_015882055.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T3P5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005012352.1">
        <property type="protein sequence ID" value="ENSCJPP00005008082.1"/>
        <property type="gene ID" value="ENSCJPG00005007296.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107323202"/>
    <dbReference type="KEGG" id="cjo:107323202"/>
    <dbReference type="CTD" id="27304"/>
    <dbReference type="GeneTree" id="ENSGT00940000160847"/>
    <dbReference type="OrthoDB" id="10261062at2759"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061605">
        <property type="term" value="F:molybdopterin-synthase adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061604">
        <property type="term" value="F:molybdopterin-synthase sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042292">
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        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="P:protein urmylation"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
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        <property type="entry name" value="PRK05690.1"/>
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        <property type="entry name" value="ADENYLYLTRANSFERASE AND SULFURTRANSFERASE MOCS3"/>
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    </dbReference>
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        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
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    </dbReference>
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    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="10 11" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4 11" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
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        <location>
            <begin position="540"/>
            <end position="650"/>
        </location>
    </feature>
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            <begin position="138"/>
            <end position="163"/>
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    <feature type="region of interest" description="Disordered" evidence="12">
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            <begin position="197"/>
            <end position="250"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="197"/>
            <end position="225"/>
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    <feature type="active site" description="Glycyl thioester intermediate; for adenylyltransferase activity" evidence="11">
        <location>
            <position position="432"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine persulfide intermediate; for sulfurtransferase activity" evidence="11">
        <location>
            <position position="605"/>
        </location>
    </feature>
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        <location>
            <position position="285"/>
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        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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        <location>
            <position position="306"/>
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            <end position="317"/>
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            <end position="375"/>
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        <ligand>
            <name>Zn(2+)</name>
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        <location>
            <position position="418"/>
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        <location>
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        <ligand>
            <name>Zn(2+)</name>
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        </ligand>
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        <location>
            <begin position="509"/>
            <end position="517"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
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            <dbReference type="ARBA" id="ARBA00022490"/>
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        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
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        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005008082.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="652" mass="71526" checksum="BA21697922E2E130" modified="2022-01-19" version="1">MVSAPYKRCSCSATCCVPSGLPSSMTMISKSVPLKAQPARERISADINRYRRISADINRYQRIPADISGYRRFVQRETRREPLCGQFDAVPVTAALGSPSRPARTYCAGSAPAATRPAAGCRARCTWAAAPTPCRRAGPPCQRRCDRDRRRGRKCPAGGGNRVRPLLSDMAEAARLRDEIERRERELRELRERLGAVMEGHRDGTERRDDGTDRRDDDTARRDDADAADAADAVFRAELPPVPGRSALSPADIQRYSRQLVLPELGVRGQLLLARCSVLVVGCGGLGCPLAQYLAAAGVGRLGLVDHDVVETSNLHRQVLHGEARTGVPKAASAAAALRRLNSGVHYVPYCGALSSRSALRLVRQYDVVADCSDNVPTRYLLNDACVLAGKPLVSGSALRLEGQLVVYNYQGGPCYRCLFPKPPPPDTVTNCADGGVLGVVPGIVGCIQALEVLKIVSGMGSTFNRFMLMFDALEGRFRNIKLRPKKSDCAVCGDNPSVTALQDYEAFCGSSATDKCRTLHLLSSKDRISVEEYKQLLDEQVPHVLLDVRPQAEVDICHLEHAVHIPLSKLEEKDKEYLEYLEKRICEEKQRTDGQASFPVYVVCKLGNDSQKAVRILQELPDKEFGPILAKDIKGGLMTWASRIDPTFPQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T3U4</accession>
    <name>A0A8C2T3U4_COTJA</name>
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        <submittedName>
            <fullName evidence="9">Ankyrin repeat and sterile alpha motif domain containing 1B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ANKS1B</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T3U4"/>
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        <property type="protein sequence ID" value="ENSCJPP00005007953.1"/>
        <property type="gene ID" value="ENSCJPG00005005999.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154572"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046875">
        <property type="term" value="F:ephrin receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048013">
        <property type="term" value="P:ephrin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01274">
        <property type="entry name" value="PTB_Anks"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09499">
        <property type="entry name" value="SAM_AIDA1AB-like_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09500">
        <property type="entry name" value="SAM_AIDA1AB-like_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ANKS1B isoform 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000015">
        <property type="entry name" value="ankyrin repeat and sterile alpha motif domain-containing protein 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000016">
        <property type="entry name" value="Ankyrin repeat and sterile alpha motif domain-containing protein 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000045">
        <property type="entry name" value="Ankyrin repeat and sterile alpha motif domain-containing protein 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033635">
        <property type="entry name" value="ANKS1/Caskin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041880">
        <property type="entry name" value="SAM_ANKS1_repeat1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041882">
        <property type="entry name" value="SAM_ANKS1_repeat2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24174">
        <property type="entry name" value="ANKYRIN REPEAT AND STERILE ALPHA MOTIF DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24174:SF3">
        <property type="entry name" value="ANKYRIN REPEAT AND STERILE ALPHA MOTIF DOMAIN-CONTAINING PROTEIN 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="58"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="91"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="127"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="193"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="225"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="8">
        <location>
            <begin position="785"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="8">
        <location>
            <begin position="856"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="domain" description="PID" evidence="7">
        <location>
            <begin position="1031"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="460"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="557"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="583"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="622"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="712"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="916"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1165"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="564"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="726"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="941"/>
            <end position="956"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005007953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1228" mass="135450" checksum="9AEC613407B98652" modified="2022-01-19" version="1">MGKDQELLEAARTGNVALVEKLLSGRKGGILGSGSGAIPLSSLLSIWRGPNINCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWRGDVDIVKILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNNKLETPLDLAALYGRLRVVKMIIKAYPNLMNCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKGSALHEAALFGKVEVARILLETGVDTNIKDSLGRTVLDILKEHPSQQSLQIVALLQDPTEGSGQARYLILTNGVSVFKGEAVTGELSKLLDEIKLCQEKEYSFEDLSHTISDHFLDNFSKISEEELMTSGIQTKLNVRPSSTCLSPREEEEDDGGENTCGPSGLWEALTPCNGCRNLGFSMLAQESYSKKRGYALEAIPSVPLDAVPSENDSSLCDFIDIAVTKKPCSLEIARVSSSRPDNAPQVAITAPGSGSHRNSSTGPTPDCSPPSPDTALKNIVKVIRPQPKQRTSIVSSLEYHRTNHSHDYFEINSSIASPSFISTPAISPANYSFGSLEDSGEKSTESELPEGHSTEQFAGLLHGSSPACDPPDNPLQLYSKRNPCTGPLDKSILSKSTIQQMQLRKESNTDPPVKKKKPPVVNRTIFHSKTKPLENHTLVGTSTRISEQWVITTGGFVERACTLGRIRSLPKTLLEMHLCKNVSKSDSNLITHPPSGKKARSNWSEPTPSQQCSKGNSERTPSFTSEWEEIDKIMSSIDAGINTGLGEMNDHTTRPRCPVQTVGQWLENIGLPQYENHLLANGFDNVQFMGSNVMEDQDLLEIGILNSGHRQRILQAIQLLPKMKQIGHDGYNPASVAEWLDSIELGDYTKSFLINGYTSMDLVKKIWEIELINVLKISLIGHRKRVLASLGDRLHEDPPQKPPRSITLREPSGNHTPPQLSPSLSQSTFTTGGSLDVPHIIMQGDARRRRNENYFDDIPRSKLERQMAQTGDWGEPSITLRPPNEATASTPVQYWQHHPEKLIFQSCDYKAFYLGSMLVKELRGTESTQDACAKMRKSTEQMKKVPTIVLSVSYKGVKFIDATNKNIIAEHEIRNISCAAQDPEDLSTFAYITKDLKTNHHYCHVFTAFDVNLAYEIILTLGQAFEVAYQLALQARKGGHSSTLPESFENKPSKPIPKPRVSIRKSVQIDPSEQKTLANLPWIVEPGQEAKRGINTKYETTIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T5Y1</accession>
    <name>A0A8C2T5Y1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein 26C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">VPS26C</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex. Component of the retriever complex, which is a heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos such as integrin alpha-5/beta-1 (ITGA5:ITGB1). The recruitment of the retriever complex to the endosomal membrane involves CCC and WASH complexes. In the endosomes, drives the retriever and recycling of NxxY-motif-containing cargo proteins by coupling to SNX17, a cargo essential for the homeostatic maintenance of numerous cell surface proteins associated with processes that include cell migration, cell adhesion, nutrient supply and cell signaling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex. Component of the heterotrimeric retriever complex consisting of VPS26C, VPS29 and VPS35L; within the complex interacts with VPS35L. Interacts with SNX17 (via C-terminus); the interaction is direct and associates SNX17 with the retriever complex. Interacts with SNX31; the interaction is direct.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS26 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015737927.1">
        <property type="nucleotide sequence ID" value="XM_015882441.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T5Y1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005013317.1">
        <property type="protein sequence ID" value="ENSCJPP00005008841.1"/>
        <property type="gene ID" value="ENSCJPG00005007843.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107323410"/>
    <dbReference type="KEGG" id="cjo:107323410"/>
    <dbReference type="CTD" id="10311"/>
    <dbReference type="GeneTree" id="ENSGT00950000183064"/>
    <dbReference type="OrthoDB" id="10263384at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.640:FF:000008">
        <property type="entry name" value="Down syndrome critical region protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.640:FF:000009">
        <property type="entry name" value="Down syndrome critical region protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028934">
        <property type="entry name" value="Vps26-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12233">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 26 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03643">
        <property type="entry name" value="Vps26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00067597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00093280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00093474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005008841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="297" mass="33062" checksum="51C2698EC9052FF3" modified="2022-01-19" version="1">MGTALDIKIKRANKVYRCGEILSGVVVITSKDTVQHQGISLTMEGSVNLQLSAKSVGVFEAFYNSVKPIQIINNTIEMVKSGKLPSGKTEIPFEFPLHVKGNKVLYETYHGVFVNIQYTLRCDMRRSLLAKDLTKTCEFIVHSLSQKGKLTPSPVDFTITPETLQNVKERASLPKFLIRGHLSSTNCVITQPLTGELVVESAEAAVKSIELQLVRVETCGCAEGYARDATEIQNIQIADGDVCRGLPIPIYMVFPRLFTCPTLETTNFKVEFEVNIVVLLHDDHLITENFPLKLCRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T6Y1</accession>
    <name>A0A8C2T6Y1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vesicle-associated membrane protein-associated protein A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">VAPA</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Endoplasmic reticulum (ER)-anchored protein that mediates the formation of contact sites between the ER and endosomes via interaction with FFAT motif-containing proteins such as STARD3 or WDR44. STARD3-VAPA interaction enables cholesterol transfer from the ER to endosomes. Via interaction with WDR44 participates in neosynthesized protein export. In addition, recruited to the plasma membrane through OSBPL3 binding. The OSBPL3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface. With OSBPL3, may regulate ER morphology. May play a role in vesicle trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Tight junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015710759.1">
        <property type="nucleotide sequence ID" value="XM_015855273.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T6Y1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005014060.1">
        <property type="protein sequence ID" value="ENSCJPP00005009403.1"/>
        <property type="gene ID" value="ENSCJPG00005008261.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107310020"/>
    <dbReference type="KEGG" id="cjo:107310020"/>
    <dbReference type="CTD" id="9218"/>
    <dbReference type="GeneTree" id="ENSGT00940000154799"/>
    <dbReference type="OrthoDB" id="264603at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031982">
        <property type="term" value="C:vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033149">
        <property type="term" value="F:FFAT motif binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035627">
        <property type="term" value="P:ceramide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030301">
        <property type="term" value="P:cholesterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090114">
        <property type="term" value="P:COPII-coated vesicle budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061817">
        <property type="term" value="P:endoplasmic reticulum-plasma membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044829">
        <property type="term" value="P:host-mediated activation of viral genome replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044828">
        <property type="term" value="P:host-mediated suppression of viral genome replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070972">
        <property type="term" value="P:protein localization to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="VESICLE-ASSOCIATED MEMBRANE PROTEIN-ASSOCIATED PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Motile_Sperm"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0007">Acetylation</keyword>
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    <keyword evidence="14 18" id="KW-0175">Coiled coil</keyword>
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        <location>
            <begin position="228"/>
            <end position="248"/>
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        <location>
            <begin position="13"/>
            <end position="130"/>
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            <begin position="136"/>
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            <begin position="172"/>
            <end position="199"/>
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        <source>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="SAM" id="Phobius"/>
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        <source>
            <dbReference type="PROSITE" id="PS50202"/>
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            <dbReference type="Ensembl" id="ENSCJPP00005009403.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="249" mass="27799" checksum="3E5C8447B2247DC3" modified="2022-01-19" version="1">MAAAGALAKHEQILVLDPPTDLKFKGPFTDVVTTNLKLRNPSDRKVCFKVKTTAPRRYCVRPNSGIIDPGSSVIVSVMLQPFDYDPNEKSKHKFMVQTIYAPPNISDMEAVWKEAKPDELMDSKLRCVFEMPNENDKLNDIDASKPAPVQNTSKQDGPMPKPHSVSLNDTETRKLVEECKRLQAEVMKLSEENRHLRDEGLRLRKIAHSDKSGSPTTLALRDNGSNSLPSLLVVIAAIFIGFFLGKFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T7L1</accession>
    <name>A0A8C2T7L1_COTJA</name>
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        <submittedName>
            <fullName evidence="4">Selectin P ligand</fullName>
        </submittedName>
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        <name evidence="4" type="primary">SELPLG</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
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        <dbReference type="NCBI Taxonomy" id="93934"/>
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            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
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            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
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                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="entry name" value="P-SELECTIN GLYCOPROTEIN LIGAND 1"/>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
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        <location>
            <begin position="142"/>
            <end position="190"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005008167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="365" mass="38531" checksum="09BE9537C2040E76" modified="2022-01-19" version="1">MALGHIMMLALLLSTLQDCKPRPMEQGLQWVWGAAEQTPAKPPLPSRRRRADAGPHSITMTPVSNDTASLGHDMLMGMETGNTTGQPKALVDTTAGPLDDSPEPHELLGTEVDNTSSQALALTTVSLLNETNSLQPLVVLGTKPPAQPGNTPKQAKASPVTTADPLDETNTPEPIAPLGTELPPKMGDSTSRAKVLVVTTTDPLDETDPPETVPGTAAQSGSTIVPNQLMESTGHGTDGTITSGTDTSMEPRSALLPTTKLSKKSGSHPPWECLLAILLLALVAGFFMVCTAVLGTLLWRRVRTARRQLGPTEMICISSLLPDNERAATNGPRRGAQVRHKLLVDAGSEADGDNLTLSSFLPEHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T7V0</accession>
    <name>A0A8C2T7V0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribosome quality control complex subunit NEMF</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Nuclear export mediator factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">NEMF</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="7">Component of the ribosome quality control complex (RQC), composed of the E3 ubiquitin ligase LTN1, TCF25 and NEMF associated with the 60S ribosomal subunit. The complex probably also contains VCP/p97 and its ubiquitin-binding cofactors. Interacts (via its N-terminus) with XPO1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NEMF family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T7V0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005011688.1">
        <property type="protein sequence ID" value="ENSCJPP00005007561.1"/>
        <property type="gene ID" value="ENSCJPG00005006660.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000018516"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904678">
        <property type="term" value="F:alpha-aminoacyl-tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140708">
        <property type="term" value="P:CAT tailing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051168">
        <property type="term" value="P:nuclear export"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065003">
        <property type="term" value="P:protein-containing complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001680">
        <property type="term" value="P:tRNA 3'-terminal CCA addition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140627">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the C-end degron rule pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.310.10:FF:000001">
        <property type="entry name" value="Nuclear export mediator factor Nemf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.310.10">
        <property type="entry name" value="ibrinogen binding protein from staphylococcus aureus domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021846">
        <property type="entry name" value="NFACT-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008532">
        <property type="entry name" value="NFACT_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051608">
        <property type="entry name" value="RQC_Subunit_NEMF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15239">
        <property type="entry name" value="NUCLEAR EXPORT MEDIATOR FACTOR NEMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15239:SF6">
        <property type="entry name" value="RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT NEMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11923">
        <property type="entry name" value="NFACT-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05670">
        <property type="entry name" value="NFACT-R_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05833">
        <property type="entry name" value="NFACT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NFACT RNA-binding" evidence="12">
        <location>
            <begin position="528"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="domain" description="NFACT protein C-terminal" evidence="13">
        <location>
            <begin position="952"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="418"/>
            <end position="456"/>
        </location>
    </feature>
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        <location>
            <begin position="696"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
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            <begin position="803"/>
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    </feature>
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            <begin position="297"/>
            <end position="344"/>
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    </feature>
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        <location>
            <begin position="483"/>
            <end position="510"/>
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    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="418"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="439"/>
            <end position="454"/>
        </location>
    </feature>
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        <location>
            <begin position="705"/>
            <end position="715"/>
        </location>
    </feature>
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            <begin position="747"/>
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            <begin position="930"/>
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    </feature>
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            <dbReference type="ARBA" id="ARBA00004123"/>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T806</accession>
    <name>A0A8C2T806_COTJA</name>
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        <recommendedName>
            <fullName evidence="2">Putative WW-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
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            <taxon>Neognathae</taxon>
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            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative WW-binding" evidence="2">
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            <begin position="118"/>
            <end position="149"/>
        </location>
    </feature>
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            <begin position="18"/>
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            <begin position="90"/>
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            <begin position="145"/>
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    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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            <dbReference type="Pfam" id="PF15017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
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            <dbReference type="Ensembl" id="ENSCJPP00005008836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="163" mass="18021" checksum="B76DB90E253D2911" modified="2022-01-19" version="1">MAKRRAEPLVCYAPFKRLLREPPLRSALSERRPRNEAAGAGSAAKRKLEEAEAPPGKRPGLRGGSPRGEQGDAAGRRRRRSEPAASQNERTAEGSDGRRGEEPAAAPVTARGQEEFNQYNSFFYWRAPLPTIDLSDIQSLHEETTSANKTPSRTDTMETEMET</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T8P9</accession>
    <name>A0A8C2T8P9_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">SIK1</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="RefSeq" id="XP_015739123.1">
        <property type="nucleotide sequence ID" value="XM_015883637.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T8P9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005014827.1">
        <property type="protein sequence ID" value="ENSCJPP00005009970.1"/>
        <property type="gene ID" value="ENSCJPG00005008725.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107323996"/>
    <dbReference type="KEGG" id="cjo:107323996"/>
    <dbReference type="CTD" id="150094"/>
    <dbReference type="GeneTree" id="ENSGT00940000154989"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071889">
        <property type="term" value="F:14-3-3 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008140">
        <property type="term" value="F:cAMP response element binding protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042826">
        <property type="term" value="F:histone deacetylase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050321">
        <property type="term" value="F:tau-protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043276">
        <property type="term" value="P:anoikis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055007">
        <property type="term" value="P:cardiac muscle cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043153">
        <property type="term" value="P:entrainment of circadian clock by photoperiod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045721">
        <property type="term" value="P:negative regulation of gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010868">
        <property type="term" value="P:negative regulation of triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000210">
        <property type="term" value="P:positive regulation of anoikis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010830">
        <property type="term" value="P:regulation of myotube differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd14071">
        <property type="entry name" value="STKc_SIK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14408">
        <property type="entry name" value="UBA_SIK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000154">
        <property type="entry name" value="Serine/threonine-protein kinase SIK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017090">
        <property type="entry name" value="Ser/Thr_kinase_SIK1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034672">
        <property type="entry name" value="SIK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057380">
        <property type="entry name" value="UBA_SIK1/2/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF47">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SIK2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23312">
        <property type="entry name" value="UBA_SIK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037014">
        <property type="entry name" value="Ser/Thr_PK_SNF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 16 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 16 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="26"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="20">
        <location>
            <begin position="302"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="351"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="671"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="351"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="673"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="32"/>
            <end position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16 17">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR037014-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR037014-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005009970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="798" mass="88949" checksum="6E59C892579FB67F" modified="2022-01-19" version="1">MVIMSEYASVPAPSAAQPRPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDPSNLEKIYREVQIMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDHLTSNGHLSESEARKKFWQILSAVEYCHSHHIVHRDLKTENLLLDANMNIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPHLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPYFMSEDCETLIRRMLVVDPTKRITISQIKQHKWMQADPSLRQQQSLSFSMQNYNSNLGDYNEQVLGIMQTLGIDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRSSQLSSRPATGRQQRPRSSEISNAEMPQDSLTNETLRSSLLYQQPQSLIQPSLQAEMDCDVNNPLQPVFFPVDPNFNGLFRNRSISPSSLLETTISEEVRQEKELEDEIKAYDHPIRIPSNTSRRHTLAEVTTHFYQHAPPCIVISSSASPTEGTSSDSCLTSSSNDSSVALSSCLAGQVMMGSPATARMTSAFLASQSDAPVLQAQSCMGGASLLPVSFQEGRRASDTSLTQGLKAFRQQLRKNARAKGFLGLNKIKGFARQVCQSSSSRAARSAMSPFQHAQPNTCIYSSSGSNREGRNLLEEVLQQQRMLQLQHHQLLQPACPQTSQTSATNGLPPPDSAGTCKASNSLLLSELQRENSFELAFGGNSQLLQPHFFGVSVSPVSSAAHLLDTHLYISSNVSPVGTTFSQQQSFSAQSPSYDAVALQHGDCEMEDLTSNQLGKFVLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T8T2</accession>
    <name>A0A8C2T8T2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Ectonucleotide pyrophosphatase/phosphodiesterase family member 3</fullName>
            <ecNumber evidence="6">3.1.4.1</ecNumber>
            <ecNumber evidence="20">3.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="30">Alkaline phosphodiesterase I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="29">Dinucleoside polyphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="27">Nucleotide diphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="28">Nucleotide pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">Phosphodiesterase I beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">Phosphodiesterase I/nucleotide pyrophosphatase 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="41" type="primary">ENPP3</name>
    </gene>
    <organism evidence="41 42">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="41" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="41" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="41" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="31">Hydrolase that metabolizes extracellular nucleotides, including ATP, GTP, UTP and CTP. Limits mast cells and basophils response during inflammation and during the chronic phases of allergic responses by eliminating extracellular ATP, a signaling molecule activating these cells in an autocrine manner. Metabolizes extracellular ATP in the lumen of the small intestine, and thereby prevents ATP-induced apoptosis of intestinal plasmacytoid dendritic cells. Has a broad specificity and can also hydrolyze UDP-GlcNAc into UMP and GlcNAc-1-phosphate and potentially several other intracellular nucleotide sugars, including UDP-GalNAc, CMP-NeuAc, GDP-Fuc, and UDP-GlcA. Thereby, could modulate glycan biosynthesis and protein glycosylation. Can hydrolyze extracellular dinucleoside polyphosphates, including the vasoactive adenosine polyphosphates as well. In addition, displays an alkaline phosphodiesterase activity in vitro.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>ATP + H2O = AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14245"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:14246"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>CTP + H2O = CMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27762"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:27763"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="35">
            <text>GTP + H2O = GMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29391"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="35">
            <dbReference type="Rhea" id="RHEA:29392"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolytically removes 5'-nucleotides successively from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides.</text>
            <dbReference type="EC" id="3.1.4.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="34">
            <text>P(1),P(3)-bis(5'-adenosyl) triphosphate + H2O = AMP + ADP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13893"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="34">
            <dbReference type="Rhea" id="RHEA:13894"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="37">
            <text>P(1),P(4)-bis(5'-adenosyl) tetraphosphate + H2O = AMP + ATP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:32039"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58141"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="37">
            <dbReference type="Rhea" id="RHEA:32040"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="33">
            <text>P(1),P(4)-bis(5'-guanosyl) tetraphosphate + H2O = GMP + GTP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:22484"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57553"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="38">
            <text>P(1),P(5)-bis(5'-adenosyl) pentaphosphate + H2O = adenosine 5'-tetraphosphate + AMP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:32051"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58450"/>
            <dbReference type="ChEBI" id="CHEBI:62041"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="38">
            <dbReference type="Rhea" id="RHEA:32052"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="36">
            <text>UDP-N-acetyl-alpha-D-glucosamine + H2O = N-acetyl-alpha-D-glucosamine 1-phosphate + UMP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:29547"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="36">
            <dbReference type="Rhea" id="RHEA:29548"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="32">
            <text>UTP + H2O = UMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29395"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="32">
            <dbReference type="Rhea" id="RHEA:29396"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-phosphate + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23996"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:23997"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer and homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Apical cell membrane</location>
            <topology evidence="4">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.4.1" evidence="6"/>
    <dbReference type="EC" id="3.6.1.9" evidence="20"/>
    <dbReference type="RefSeq" id="XP_015713993.1">
        <property type="nucleotide sequence ID" value="XM_015858507.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T8T2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005015151.1">
        <property type="protein sequence ID" value="ENSCJPP00005010180.1"/>
        <property type="gene ID" value="ENSCJPG00005008921.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107311729"/>
    <dbReference type="KEGG" id="cjo:107311729"/>
    <dbReference type="CTD" id="5169"/>
    <dbReference type="GeneTree" id="ENSGT00940000159640"/>
    <dbReference type="OrthoDB" id="415411at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034432">
        <property type="term" value="F:bis(5'-adenosyl)-pentaphosphatase activity"/>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T9H3</accession>
    <name>A0A8C2T9H3_COTJA</name>
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        <name type="scientific">Coturnix japonica</name>
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            <taxon>Galliformes</taxon>
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            <taxon>Perdicinae</taxon>
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        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
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            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
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        <scope>IDENTIFICATION</scope>
    </reference>
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    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="496"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="644"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="4"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="270"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="310"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="371"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="506"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="666"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005010480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="697" mass="78796" checksum="AFBA63089EA52080" modified="2022-01-19" version="1">MDLRKQLENTERNWNKEKMELLEKFDNERKEWECQWKVMQKKIEELYQEVKLRRENNMNVHDNRAIQSKMLQLSMHSPASEKCETVELNYQHNVVNDGMERGILLSKTEPECKEIKTKRKNDTLLMDNLAFENHEELEDSLSIKTSKKNAKSYIGDLNVALKELARVSEELCSYQEEIRKKSNHRRMKSVPFLGKFEETQNTVILPEMNNLSNNESQSSVALEKEEHNNRKNLMSSTKVLKDMSYSSLTGNGGEVFRPCQQKEAPPVPPRSTSRHLTSSLSTVVQLPEAPMRDPGIKSNCKFQDSRSGRKLTNPSSVKQNETKMACANEKQTGKGPVIVTAAIPVTKNECVAPSFCHNTWAYDVGKDSKNEPSPLSAQKSCSDGNMAHSNRMHQKQSSKSHFSPYYCNDFYAAAALHIDLLGDSSCALGKAQRNETLAAKIDEFNRTVFHTDKRNTTLQENQVTRTALEDHKPCSPPCDSAISRTETVDSSCVSNPKLSAAKEQETSNPSKVVRTGGQQKQINGLPNTSGYRHMLHEHDWRPSNLSGRPRSADSRSNYGVVEKLLKNYEKSAVISPCNAKYCKDKWTRANSESTDGGCETRNQYLEMLPSEQGKQEFLRNSGRHIGQQLKQGRERQKLPEISVPAKCSNGKGFSRPARPANRRLPSRWASRSPSAPPAVRRTAYNCSVSFRSETSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TAH0</accession>
    <name>A0A8C2TAH0_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Myosin IB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">MYO1B</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TAH0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005014615.1">
        <property type="protein sequence ID" value="ENSCJPP00005009822.1"/>
        <property type="gene ID" value="ENSCJPG00005008597.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155752"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032588">
        <property type="term" value="C:trans-Golgi network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006892">
        <property type="term" value="P:post-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010926">
        <property type="entry name" value="Myosin_TH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34969">
        <property type="entry name" value="OS01G0621700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34969:SF1">
        <property type="entry name" value="TH1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06017">
        <property type="entry name" value="Myosin_TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51757">
        <property type="entry name" value="TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TH1" evidence="1">
        <location>
            <begin position="176"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005009822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="360" mass="41966" checksum="0F74108BBC890250" modified="2022-01-19" version="1">MQIERSRVTLNCIFNCLQARKLLRELKHQKRCNEAATIIAAYWHGTQARRELKRLKEEARRKHAVAVIWAYWLGLKVRREYRKFFRANAGRKIYEFTLQRLMQKYFLEMKNKMPSLSPIDKNWPARPYLFLDSTHKELKRIFHLWRCKKYRDQFTDQQKLIYEEKLEASELFKDKKALYPASVGQPFQGAYLEISKNPKYKKLKDAVDEKIIIAEVVNKINRANGKATSRIFLLTKNNVLLADQKSGNIKSEVPLGDVTKVSMSSQNDGFFAVHLKEGSGAASKGDFLLSSDHLIEMATKLYRTTLSQTKQKLNIEISDEFLVQFRQDKVCVKFIQGSQKNGNIPTCKRKNNRLLEVAVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TCA4</accession>
    <name>A0A8C2TCA4_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Beta-1,4-galactosyltransferase</fullName>
            <shortName evidence="18">Beta-1,4-GalTase</shortName>
            <ecNumber evidence="18">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">B4GALT6</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine + UDP-alpha-D-galactose = a beta-D-Gal-(1-&gt;4)-beta-D-Glc-(1&lt;-&gt;1)-Cer(d18:1(4E)) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31495"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17950"/>
            <dbReference type="ChEBI" id="CHEBI:22801"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="2.4.1.274"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:31496"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 18">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="18">Golgi apparatus membrane</location>
            <topology evidence="18">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">Golgi stack membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 18">Belongs to the glycosyltransferase 7 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="18"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2TCA4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005016782.1">
        <property type="protein sequence ID" value="ENSCJPP00005011494.1"/>
        <property type="gene ID" value="ENSCJPG00005009874.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158138"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008489">
        <property type="term" value="F:UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022010">
        <property type="term" value="P:central nervous system myelination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021955">
        <property type="term" value="P:central nervous system neuron axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001572">
        <property type="term" value="P:lactosylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042551">
        <property type="term" value="P:neuron maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00899">
        <property type="entry name" value="b4GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000037">
        <property type="entry name" value="Beta-1,4-galactosyltransferase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003859">
        <property type="entry name" value="Galactosyl_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027791">
        <property type="entry name" value="Galactosyl_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027995">
        <property type="entry name" value="Galactosyl_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300">
        <property type="entry name" value="BETA-1,4-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300:SF47">
        <property type="entry name" value="BETA-1,4-GALACTOSYLTRANSFERASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02709">
        <property type="entry name" value="Glyco_transf_7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13733">
        <property type="entry name" value="Glyco_transf_7N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02050">
        <property type="entry name" value="B14GALTRFASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15 18" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 18" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="18" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16 18" id="KW-0464">Manganese</keyword>
    <keyword evidence="13 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 18" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="7 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Galactosyltransferase N-terminal" evidence="20">
        <location>
            <begin position="108"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Galactosyltransferase C-terminal" evidence="19">
        <location>
            <begin position="247"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00052889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU368121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF13733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005011494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="398" mass="46316" checksum="214082BC8118F4B7" modified="2022-01-19" version="1">MPVFRKALRVSNRSMLAFIFFFSFSSSCLYFIYVAPGIANTYLFMVQARGIMLRENVKTIGHMIRLYTNKNTTLNGTDYPEGNNSSDCVAQTTMYLPENFTYSPYQACPEKLPYMRGLIDVNMSEISFDEIQQLFSKDLDIKPGGHWKPKDCKPRWKVAIIVPFRNRHEHLPIFFRHLIPMLQKQRLEFAFYVVEQTGTQPFNRAMLFNVGFKEAMKDVVWDCIIFHDVDHLPENDRNYYGCGEMPRHFAAKLDKYMYILPYNEFFGGVSGLTVEQFKKINGFPNAFWGWGGEDDDLWNRVHYAGYNVTRPEGDLGKYKSIPHHHRGEVQFLGRTYFEFNSSQDPSSTSLCNLTRRFGAGLPRAESRTFIKRGCLESEEPFRATHSCHDTALQRPQQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TCL5</accession>
    <name>A0A8C2TCL5_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="17">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">PLCH2</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This phospholipase activity is very sensitive to calcium. May be important for formation and maintenance of the neuronal network in the postnatal brain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:33180"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="17"/>
    <dbReference type="Ensembl" id="ENSCJPT00005016144.1">
        <property type="protein sequence ID" value="ENSCJPP00005010994.1"/>
        <property type="gene ID" value="ENSCJPG00005009504.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158374"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046488">
        <property type="term" value="P:phosphatidylinositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007200">
        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16221">
        <property type="entry name" value="EFh_PI-PLCeta2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13364">
        <property type="entry name" value="PH_PLC_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000005">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000036">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000063">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000018">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.190:FF:000002">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.190:FF:000006">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046971">
        <property type="entry name" value="PLC-eta2_EFh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015359">
        <property type="entry name" value="PLC_EF-hand-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF166">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ETA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09279">
        <property type="entry name" value="EF-hand_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16457">
        <property type="entry name" value="PH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 17" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="12 17" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="14" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="EF-hand" evidence="21">
        <location>
            <begin position="165"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="21">
        <location>
            <begin position="201"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="PI-PLC Y-box" evidence="20">
        <location>
            <begin position="633"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="19">
        <location>
            <begin position="747"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="473"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="530"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="933"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1052"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1323"/>
            <end position="1375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1395"/>
            <end position="1415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1477"/>
            <end position="1502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="475"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="533"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="548"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="582"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="955"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1059"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1345"/>
            <end position="1354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00054490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005010994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1585" mass="177530" checksum="45D322083F59A27F" modified="2022-01-19" version="1">MALPSPKSIAGDLTQREELMLHNESCFHFLSANVITVVERCMSSMQAGTQMIKLRGGSKGLVRFYYLDEHRTCIRWRPSRKNERAKISIDSIQEVCEGKQSEIFQRYADGSFDPNCCFSIYYGDHMESLDLVSSSGDEARTWITGLKYLMAGISDEDSLSKRQRTRDQWLKQTFDEADKNGDGCLSINEVLQLMHKLNVNLPRQKVKQMFKEADTDDNQGTLGFDEFCTFYKMMSTRRDLYLLMLTYSNHKDFLDADDLRRFLENEQKMTDVTREHCLEIINKFEPCLENKKAGALGIDGFTNYMRSPSGDIFNPEHYQVNQDMSYPLSHYFITSSHNTYLMGDQLMSQSRVDMYAWVLQSGCRCVEVDCWDGPDGEPIVHHGYTLTSKILFKDVIETINKYAFIKNEYPVILSIENHCSVIQQKKMAQYLTEILGDKLDLSSVHNDDSTRLPSPASLKGKILVKGKKLPANISDDAEEGEVSDEDSADEIDDDCKIMNGDASTNRKRVENIAKKKLDSLIKESKIRDCEDPNNFTVTTLPSSGKAGQKSDSKKNKLEDDAESGEDFSANKRQSRTLMGSFSKRKKKGSKLKKSTSLEEGEDDADSQGNVARGSVHYTRINRQKKTMKLSRALSDLVKYTKSVGIHDVETEISSSWQVSSFSETKAHQILQQKPAQYLRFNQHQLSRIYPSSYRVDSSNYNPQPFWNAGCQLVALNYQSEGRMLQLNRAKFSANGNCGYVLKPNCMCQGIFNPNSEDPLPGQLKKQLVLRIISGQQLPKPRDSMLGDRGEIIDPFVEVEVIGLPVDCFKEQTRVVDDNGFNPMWEETLVFTLHMPEIALIRFLVWDHDPIGRDFIGQRTIAFSSMMPGYRHVYLEGIEEASIFVHVAINDICGKVKQALGLKGLFLRNPKQASLDSHAAGQLHRKHSFSSHILRRTASAPTKSQKKKKGFPEIVFDTKDNSSEGASEDHEAEAASQPRFEQESESASLSPAPRDGASGEVHGKGLKDVSHFSMQRSVTSLCSLETITEEPVIANDSHHASLFFPLTITPYSDSEEGSMSDYSTESQTKGSNPSNRPPEPLLTTEQRPNLAAEDQVQIATKAADINVLVQDSERTSMAGFLKEENGWTQACSEAEDQVDLAVHPQKAWLVVAEAKSAGQPVENCQKQNDQTGQIWKDLKTTAELKSQKPGAAAVLQQNSVINGTHPTLSPDIFQKAQAAQALPVSQTSSYMLIRKSKSEGLKKSDSSALIKNPSSLSPAAEVYFDATVNDRIWSKLDCSNHRDSMSSSSSMSSNDTVIDLSLPNLARKSLPDLGIRHENFEPLAMRRGIRPRSATTSGNEMPIVSKSKSNPNLRSDQLPVDELCPRPLARSPQDAFSSIPRRHTWSRLYIESLRQSSNKSKAEDKVGNNQAKSKSLGDLTSDDIVCTFESKYRSISRSFVTRSMREQRRSAGLRTSVKPQDELTEQLKKLTAFQQENDITSPISLDPAESEEEAESLGLLRRSSSRSQSRVRYIANRAKQAQERQRLQSLGQLGGSPIEERGNPEGACSVAKAVCMDMASPAVFTSQPKNQTDYNTDTEVFFMLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TDM1</accession>
    <name>A0A8C2TDM1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Phosphodiesterase</fullName>
            <ecNumber evidence="11">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">PDE9A</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. Highly specific: compared to other members of the cyclic nucleotide phosphodiesterase family, has the highest affinity and selectivity for cGMP. Specifically regulates natriuretic-peptide-dependent cGMP signaling in heart, acting as a regulator of cardiac hypertrophy in myocytes and muscle. Does not regulate nitric oxide-dependent cGMP in heart. Additional experiments are required to confirm whether its ability to hydrolyze natriuretic-peptide-dependent cGMP is specific to heart or is a general feature of the protein. In brain, involved in cognitive function, such as learning and long-term memory.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3',5'-cyclic GMP + H2O = GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16957"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="EC" id="3.1.4.35"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="11">Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Purine metabolism; 3',5'-cyclic GMP degradation; GMP from 3',5'-cyclic GMP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the cyclic nucleotide phosphodiesterase family. PDE9 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="11"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2TDM1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005014805.1">
        <property type="protein sequence ID" value="ENSCJPP00005009951.1"/>
        <property type="gene ID" value="ENSCJPG00005008711.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155587"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047555">
        <property type="term" value="F:3',5'-cyclic-GMP phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046069">
        <property type="term" value="P:cGMP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010613">
        <property type="term" value="P:positive regulation of cardiac muscle hypertrophy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1300.10:FF:000006">
        <property type="entry name" value="Phosphodiesterase 9A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023088">
        <property type="entry name" value="PDEase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00387">
        <property type="entry name" value="PDIESTERASE1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0140">cGMP</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDEase" evidence="13">
        <location>
            <begin position="247"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="323"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="323"/>
            <end position="327"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="363"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="473"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="473"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="524"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00058791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00061167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005009951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="589" mass="66977" checksum="59D4353786B41088" modified="2022-01-19" version="1">MPRKAVAMGMDASGAASPPAHGIWMRPGAPREGGGGETGTNNACTLEEGPSQNESVVGHGGAGTPSCQAAVAQPGGISLVFCSAGKPGKSSTVARWDLPLQLTGPSVFIWILMEEFKRNTTISLLTADNCMVSIDPTMPANSERSPYKVIPVATGQLSEKEELFQNLLGQIAEQFSRVFKINELKTEVANHLAMLEKKVELEGLKVVEIEKCKSDIKKMREEMAARSSRTTCPCKYSFLDENRRPTPRRDVPSYPKYMLSQETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVKDFNINPITLKRWLLCIHDNYRNNPFHNFRHCFCVTQMMYSMISLCSLQEKFSQIDILILMTAAVCHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQIISQPEYNIFSNVDQDQFKQIRQGIITLILATDMARHAEILDSFKEKMENFDYSNEEHMTCLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKPTAQIGFLKFVLIPMFETVTKLFPEVEEMMLQPLWESRDRYEELKQIDDAMKELQKKKSDSLTTSTTEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TEC5</accession>
    <name>A0A8C2TEC5_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Adhesion G protein-coupled receptor L3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">Latrophilin-3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="36" type="primary">ADGRL3</name>
    </gene>
    <organism evidence="36 37">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="36" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="36" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="36" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="24">Orphan adhesion G-protein coupled receptor (aGPCR), which mediates synapse specificity. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. Isoform 1 is specifically coupled to G(s) G proteins and mediates activation of adenylate cyclase activity. Following G-protein coupled receptor activation, undergoes liquid-liquid phase transition, associates with (1) cell adhesion molecules that are expressed at the surface of adjacent cells, as well as (2) PDZ-containing proteins, such as SHANK3 and DLG4, in the cytoplasm to direct synapse formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="26">Heterodimer of 2 chains generated by proteolytic processing; the large extracellular N-terminal fragment and the membrane-bound C-terminal fragment predominantly remain associated and non-covalently linked. Interacts (via olfactomedin-like domain) with FLRT1 (via extracellular domain). Interacts (via olfactomedin-like domain) with FLRT2 (via extracellular domain). Interacts (via olfactomedin-like domain) with FLRT3 (via extracellular domain); the interaction is direct. Interacts (via extracellular domain) with TENM1. Interacts (via extracellular domain) with TENM2. Interacts (via extracellular domain) with TENM3. Identified in a complex with FLRT3 and UNC5B; does not interact with UNC5B by itself. Identified in a complex with FLRT3 and UNC5D; does not interact with UNC5D by itself.</text>
    </comment>
    <comment type="subunit">
        <text evidence="25">Interacts (via PDZ-binding motif) with SHANK3. Interacts (via PDZ-binding motif) with DLG4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Axon</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="21">Postsynaptic cell membrane</location>
            <topology evidence="21">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.</text>
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    <keyword evidence="10" id="KW-0965">Cell junction</keyword>
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        <source>
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        <source>
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        <source>
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        <source>
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        </source>
    </evidence>
    <sequence length="1472" mass="163893" checksum="623C199AA11DCC6B" modified="2022-01-19" version="1">MWSSQLLFFTMLLTPLAHAFSRAPVPMAVVRRELSCESYPIELRCPGTDVIMIESANYGRTDDKICDSDPAQMENIRCYLPDAYKIMTQRCSNRTQCAVVAGPDVFPDPCPGTYKYLEVQYECVPYIFLCPGLLKGVYQSEHLFESDHQSGAWCKDPLQASDKIYYMPWTPYRTDTLTEYSSKDDFIAGRPTTTYKLPHRVDGTGFVVYDGALFFNKERTRNIVKFDLRTRIKSGEAIIANANYHDTSPYRWGGKSDIDLAVDENGLWVIYATEQNNGKIVISQLNPYTLRIEGTWDTAYDKRSASNAFMICGILYVVKSVYEDDDNEATGNKIDYIYNTDQSKDSMVDVPFPNSYQYIAAVDYNPRDNLLYVWNNYHVVKYSLDFGPLDSRAGVSTSGALGPVSTTASTTPRMATSSTGRPTTTSALGRRNRSTSMPSPMADVPDEMTTHLPPASSQLPPAGAESCDPMEARDIMWSRTRQGQVAKQPCPMGSIGVATFRCLAPDGIWEPQGPDLSNCSSPWINHITQKMKSGEMAANIARELAEHTRNHLYAGDITYSVSAMVQLVNLLDVQLRNLTPGGKDSAARSLNKLQKRERSCRAYVQAMVETVNNLLQPQALNAWRDLNASEQQRAATKLLDTVEDSAFVLADNLLKTDIVRENTDNIQLEVARLSTDGNLEDLKFPQNTGHGSAIQLSANTLKQNGRNGEIRVAFVLYNNLGTYLSTENASMKLGTEAMSTNHSVIVNSPVITAAINKEFSNKVYLADPVVFTVKHIKQSEENFNPNCSFWSYTKRTMTGYWSTQGCRLLTTNKTHTTCSCNHLTNFAVLMAHVEVKHSDAVHDLLLDFITWVGILLSLVCLLICIFTFCFFRGLQSDRNTIHKNLCINLFVAELLFLIGINRTDQPIACAVFAALLHFFFLAAFTWMFLEGVQLYIMLVEVFESEHSRRKYFYLVGYGMPALIVAVSAAVDYRSYGTDKVCWLRLDTYFIWSFIGPATLIIMLNVIFLGIALYKMFHHTAILKPESGCLDNIKSWVIGAIALLCLLGLTWAFGLMYINESTVIMAYLFTIFNSLQGMFIFIFHCVLQKKVRKEYGKCLRTHCCSGKSTESSIGSGKTSGSRTPGRYSTGSQSRIRRMWNDTVRKQSESSFITGDINSSASLNRGAMANHLITNALLRPHGTNNPYNTLLGESAVYNNPSVSMYNAQEGLLNNARDTSVTDTLPLNGNHGNSYSIASGEYLSNCVQILDRGYNHTENALEKKILKELTSNYIPSYLNNHERSSEQSRNLMNKLVNSVGGGSEDDAIVLDDATSFTHEESLGLELIHEESDAPLLPPRVYSADGPQPHLYSRRRIPQDNSESFFPLLTNEHTDDLQSPNRDSLYTSMPALAGMPVAESVAASTQTDPPAAKSGDADDVYYKSMPNLGSRNHVHQLHTYYQLGRGSSDGFIVPPNKEGTSPDGSAKGPAHLVTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TEG8</accession>
    <name>A0A8C2TEG8_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">RAD54 like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">RAD54L2</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSCJPT00005017992.1">
        <property type="protein sequence ID" value="ENSCJPP00005012419.1"/>
        <property type="gene ID" value="ENSCJPG00005010553.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155763"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18069">
        <property type="entry name" value="DEXHc_ARIP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.850">
        <property type="entry name" value="SWI2/SNF2 ATPases, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044574">
        <property type="entry name" value="ARIP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044573">
        <property type="entry name" value="ARIP4_DEXHc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45797:SF1">
        <property type="entry name" value="HELICASE ARIP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45797">
        <property type="entry name" value="RAD54-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="258"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="694"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="173"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="981"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1085"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1212"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1407"/>
            <end position="1430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="60"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1099"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1113"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1163"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1416"/>
            <end position="1430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005012419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1430" mass="158341" checksum="B9CE932A6384E5A4" modified="2022-01-19" version="1">PSCAAASDQPQEAVFSSDHVEHTEDGEWQRSTSTTSSQSERAERLLQNQHKSLASEDTKKKRAQKPSHMRRNIRKLLREDQLEAVTKAAQQEELERRKRLEQQRKDYPATIPTVSPEFLPEDIIFRAAEATQLPPQVLAEEVICLDSTSSGSEDDTKGKNSIKDVIELSSGEDDALQIVDSSDSGNEGEEDGSEESSGSHVNDALNQSDALGQVIVNINHPPNEEDIFLAPQLAHAVKPHQIGGIRFLYDNLVESLERFKTSSGFGCILAHSMGLGKTIQVISFLDVLFRHTEAKTVLAIVPVNTLQNWLAEFNMWLPAPENLPADYNSKEVQPRTFKVHILNDEHKTTAARAKVVNDWVMEGGVLLMGYEMYRLLSLKKSFATGRKKKTKKQTGPVIIDLDEEDRQQELLKGIEKALSRPGPDVVICDEGHRIKNCHASTSQALKNIRSRRRVVLTGYPLQNNLIEYWCMVDFVRPDFLGSRQEFSNMFERPILNGQCIDSTPQDVRLMRYRSHVLHSLLEGFVQRRGHNVLKVQLPSKEEHVILVRLSKIQRALYTEFMNRFRDAGNSGWLGLNPLKAFCVCCKIWNHPDVLYEALQKENLANEQDLDVDDLGTASTNSRCQPQGVKVKTESNALPSPVGEATNSKFLQSVGFNPFQERANQVVTYEWAKDILCDYQTGVLENSPKMVLLFHLVEESMKLGDKILVFSQSLSTLSVIEEFLAKRPMPNPPGSDGGVHNWVRNISYYRLDGSTSASERERLINQFNDPSNASVWLFLLSTRAGCLGVNLIGANRVVVFDASWNPCHDAQAVCRVYRYGQKKPCHIYRLVSDYTLEKKIYDRQISKQGMSDRVVDDLNPVLNFTRREVENLLHFVEEESDLAQLSLNPSKMKESVLQLACLKYPHLITKEPFQHESLLIDRKEHKLTKAEKKAAKKSYEEEKRASVPYTRPSYAQYYPASDQSLTSIPAFSQRNWRPALKGEDKPVASVRPVQSTPIPMMPRHVPLGSAGSTSSSNPAVNFPINYLQRAGVLVQKIVTTTDIVIPGTNTSTDVQARISAGESIHIIRGTKGTYIRTSDGRIFAIRTTGKPKGNEDRRAAASGSQSSSLESASNGRHSASSPQLPSAEELTRPISPDSPEIISELQQYAEAAAARESRHSSPSTTTAQGHPSRTDSAPSIATRGAEQRAGIHCVAASVSSALPASGQHVDAHSVLDLRGNKRKSSSPSTPEEQTRRQQKKRQLPSSVQPYEHGYPVSGGFAMPPVSLNHNLTHPFASQPGNSLYMGAGSSYYQLPNLLPDPHLVFPVTTDPLLTAGTASSSAATSATASVPSFMLNPSLTGVLPSYSLPFTQSLLPEPRMFAPFPAPVLPSSLPRSMASAYPGYVSPHSGYPAGGFLRSQVPQFEPQEVPEVGCSSNDEDKDDDVIEITGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TF26</accession>
    <name>A0A8C2TF26_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">PJA2</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="RefSeq" id="XP_015704934.1">
        <property type="nucleotide sequence ID" value="XM_015849448.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015704935.1">
        <property type="nucleotide sequence ID" value="XM_015849449.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015704936.1">
        <property type="nucleotide sequence ID" value="XM_015849450.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015704937.1">
        <property type="nucleotide sequence ID" value="XM_015849451.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TF26"/>
    <dbReference type="Ensembl" id="ENSCJPT00005016401.1">
        <property type="protein sequence ID" value="ENSCJPP00005011192.1"/>
        <property type="gene ID" value="ENSCJPG00005009646.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107306352"/>
    <dbReference type="KEGG" id="cjo:107306352"/>
    <dbReference type="CTD" id="9867"/>
    <dbReference type="GeneTree" id="ENSGT00940000154585"/>
    <dbReference type="OrthoDB" id="21204at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome Z"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16465">
        <property type="entry name" value="RING-H2_PJA1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000152">
        <property type="entry name" value="E3 ubiquitin-protein ligase Praja-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051834">
        <property type="entry name" value="RING_finger_E3_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931:SF3">
        <property type="entry name" value="RING ZINC FINGER-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931">
        <property type="entry name" value="SI:CH211-59O9.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="622"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="314"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005011192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="690" mass="76313" checksum="C88955F452493F19" modified="2022-01-19" version="1">MGQEAGKPAWPKPTGGYRTITGRRYGRRHAYVSFRPSMNSQDGSQHQDNGEYEGLELSDVQEQISLCSGPLVQVTPGLLDEPLLENDGTGKPICRAVFRKTSEAIPSPFSYSVEGSQISGDIISPDKNSEDLAKYASGECDDLNGCNGIAFVNIDSYEPDSSDGEDDDGQDQLCLVREEAGVLQETLDNLVSELEKDVESLTHLRSQLTTLNDRVSRECCKEIEPVPLTRHLSTDSDFMHPNNGTYKKSAEDQAILKSNQSGASCETQMVNTVNIENRTCVATCNELSINGGETEQGDSPELIVRPKVRKLNSTNHLDREKLSSNNEEERSSRKEGEIDEIKQGCAEFSFKNDAEKLSSSMLFDSKWYSGPQSSTKVDLRRNRSAQEQKDMLDDSSFWDAFEDCSRHLSVSHRDEDSSECSDGEWPTAGPIYFAAAEKDQSSSDESWETVPGKEEHEAEVLSSSSGIEVNVDPCFHGGVQTFLEEGEIPWLQYHEEIESSSDEEDDPSSDFVHPGFFMLDGNNNLEDDSSMSEDLDVEWRLLDELGDGLGVAQVISYVDPQFFTYMALEERLALAMEVNALAHLESLAVDVEQAHPPASKESIDCLPQIIVTDDYDGQEQCCTICCSEYVKDEVITELPCHHLFHKPCVTLWLQKSGTCPVCRHVLAPMLPEAAAATASFLPDDDSSSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TH34</accession>
    <name>A0A8C2TH34_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TH34"/>
    <dbReference type="Ensembl" id="ENSCJPT00005016630.1">
        <property type="protein sequence ID" value="ENSCJPP00005011379.1"/>
        <property type="gene ID" value="ENSCJPG00005009774.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000186319"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019815">
        <property type="term" value="C:B cell receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030183">
        <property type="term" value="P:B cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050853">
        <property type="term" value="P:B cell receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14334">
        <property type="entry name" value="B-CELL ANTIGEN RECEPTOR COMPLEX-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14334:SF3">
        <property type="entry name" value="TRANSMEMBRANE AND IMMUNOGLOBULIN DOMAIN CONTAINING 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="29"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005011379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="182" mass="19541" checksum="729DB9200486B87B" modified="2022-01-19" version="1">MGWMGWDGMGSVGALQVNQDPPELWAAAGTNVSLRCQLQTAQRWTMARVTWLKDGGHEVLCEHRVTHLPPKATTMPCATPHIHLTWSPPHANLSLHGAQEGDAGRYVCHVTIEVPYLATATGNGTMLHVSAGMWGAQGGGQHLVGSVRTPMSVMVMWGLCVWGHSGDGDRTALTVLPLCCRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TH50</accession>
    <name>A0A8C2TH50_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16 18">Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1</fullName>
            <ecNumber evidence="5 18">2.4.1.122</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">C1GALT1</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17 18">
            <text>an N-acetyl-alpha-D-galactosaminyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1-&gt;3)-N-acetyl-alpha-D-galactosaminyl derivative + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15621"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28257"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="ChEBI" id="CHEBI:133470"/>
            <dbReference type="EC" id="2.4.1.122"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 18">Membrane</location>
            <topology evidence="2 18">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.122" evidence="5 18"/>
    <dbReference type="RefSeq" id="XP_015709112.1">
        <property type="nucleotide sequence ID" value="XM_015853626.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015709114.1">
        <property type="nucleotide sequence ID" value="XM_015853628.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015709115.1">
        <property type="nucleotide sequence ID" value="XM_015853629.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TH50"/>
    <dbReference type="Ensembl" id="ENSCJPT00005019639.1">
        <property type="protein sequence ID" value="ENSCJPP00005013696.1"/>
        <property type="gene ID" value="ENSCJPG00005011527.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107309116"/>
    <dbReference type="KEGG" id="cjo:107309116"/>
    <dbReference type="CTD" id="56913"/>
    <dbReference type="GeneTree" id="ENSGT00940000155000"/>
    <dbReference type="OrthoDB" id="414175at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016263">
        <property type="term" value="F:glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001525">
        <property type="term" value="P:angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060576">
        <property type="term" value="P:intestinal epithelial cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001822">
        <property type="term" value="P:kidney development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.50:FF:000007">
        <property type="entry name" value="Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026050">
        <property type="entry name" value="C1GALT1/C1GALT1_chp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003378">
        <property type="entry name" value="Fringe-like_glycosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033">
        <property type="entry name" value="BETA1,3-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033:SF13">
        <property type="entry name" value="GLYCOPROTEIN-N-ACETYLGALACTOSAMINE 3-BETA-GALACTOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02434">
        <property type="entry name" value="Fringe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 18" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="15 18" id="KW-0464">Manganese</keyword>
    <keyword evidence="13 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 18" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="Fringe-like glycosyltransferase" evidence="20">
        <location>
            <begin position="90"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="342"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00040898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU364049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF02434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005013696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="366" mass="42704" checksum="C77B36FC97A7971D" modified="2022-01-19" version="1">MASSKSLMNLLIFSFGSAIGFFLCYLLFSMILEEQVEIQPHILHNDPHGQHSEDTDNNQLQGQMNFNADSGQHRDENKNVADELYQKVKILCWVMTGPQNLEKKARHVKATWAQRCNKILFMSSEENKDFPTVGLETKEGRDQLYWKTIKAFQYVYDHYFDEADWFMKADDDTYVILDNLRWLLSKYSPEQPIYFGRRFKPYVKQGYMSGGAGYVLSKEALKRFVTAFKTNKCSHSSSIEDLALGKCMEIINVQAGDSRDTNGRETFHPFVPEHLLIRGYLPKTFWYWNYNYYPAVEGPGCCSDLAVSFHYVDSMTMYHLEYLVYHLRPYGYSYRYSPDSAKSLEEQNKNEAQEDNPKLKQKTSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TH94</accession>
    <name>A0A8C2TH94_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">E3 ubiquitin-protein ligase RNF126</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">RING finger protein 126</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">RNF126</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Interacts with CCDC50, EGFR, FLT3 and SCAMP3. Interacts with BAG6 (via ubiquitin-like domain); required for BAG6-dependent ubiquitination of proteins mislocalized to the cytosol. Interacts with CDKN1A. Interacts with AICDA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="RefSeq" id="XP_015741840.1">
        <property type="nucleotide sequence ID" value="XM_015886354.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TH94"/>
    <dbReference type="Ensembl" id="ENSCJPT00005017632.1">
        <property type="protein sequence ID" value="ENSCJPP00005012152.1"/>
        <property type="gene ID" value="ENSCJPG00005010341.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107325460"/>
    <dbReference type="KEGG" id="cjo:107325460"/>
    <dbReference type="CTD" id="55658"/>
    <dbReference type="GeneTree" id="ENSGT00940000157113"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005154">
        <property type="term" value="F:epidermal growth factor receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071629">
        <property type="term" value="P:cytoplasm protein quality control by the ubiquitin-proteasome system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110025">
        <property type="term" value="P:DNA strand resection involved in replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042059">
        <property type="term" value="P:negative regulation of epidermal growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905168">
        <property type="term" value="P:positive regulation of double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044314">
        <property type="term" value="P:protein K27-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035519">
        <property type="term" value="P:protein K29-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070936">
        <property type="term" value="P:protein K48-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070534">
        <property type="term" value="P:protein K63-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042127">
        <property type="term" value="P:regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043162">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd16801">
        <property type="entry name" value="RING-H2_RNF126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000253">
        <property type="entry name" value="E3 ubiquitin-protein ligase RNF126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039571">
        <property type="entry name" value="RNF126_RING-H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15710">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PRAJA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15710:SF21">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="14" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="11" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="21">
        <location>
            <begin position="230"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="95"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="278"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="102"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="20">
        <location>
            <begin position="116"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00061906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00067468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00080437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005012152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="312" mass="34361" checksum="AEC2616EDD591A57" modified="2022-01-19" version="1">MAEASPQPGRFFCHCCSAEIAPRLPDYICPRCESGFIEELPEEPRNTENETSTSASTSDQNRHPFENVDQHLFTLPQGYGQFAFGIFDDGFEIPFGSNVQSEDNRDSENRREREHQSRHRYGARQPRARLATRRAAGRHEGVPTLEGIIQQLVNGIIAPTTIPNLGLGPWGVLHSNPMDYAWGANGLDAIITQLLNQFENTGPPPADKEKIQALPTVQITQEHVDSGLECPVCKEDYTVGENVRQLPCNHLFHNSCIVPWLEQHDTCPVCRKSLSGQNTATNPPGLTGMNFSSSSSSSSSSSPSNENSSNNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TH97</accession>
    <name>A0A8C2TH97_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Exocyst complex component 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Exocyst complex component Sec3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">EXOC1</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8. Interacts with EEF1A1. Interacts with SLC6A9; interaction increases the transporter capacity of SLC6A9 probably by promoting its insertion into the cell membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Midbody</location>
            <location evidence="3">Midbody ring</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SEC3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015717778.1">
        <property type="nucleotide sequence ID" value="XM_015862292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TH97"/>
    <dbReference type="Ensembl" id="ENSCJPT00005018162.1">
        <property type="protein sequence ID" value="ENSCJPP00005012547.1"/>
        <property type="gene ID" value="ENSCJPG00005010673.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107313738"/>
    <dbReference type="CTD" id="55763"/>
    <dbReference type="GeneTree" id="ENSGT00940000158640"/>
    <dbReference type="OrthoDB" id="27109at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090543">
        <property type="term" value="C:Flemming body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14683">
        <property type="entry name" value="PH-EXOC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.90:FF:000001">
        <property type="entry name" value="exocyst complex component 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028258">
        <property type="entry name" value="Sec3-PIP2_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048628">
        <property type="entry name" value="Sec3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019160">
        <property type="entry name" value="Sec3_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16092:SF33">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16092">
        <property type="entry name" value="SEC3/SYNTAXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15277">
        <property type="entry name" value="Sec3-PIP2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20654">
        <property type="entry name" value="Sec3_C-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09763">
        <property type="entry name" value="Sec3_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01313">
        <property type="entry name" value="Sec3-PIP2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12 17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component Sec3 PIP2-binding N-terminal" evidence="19">
        <location>
            <begin position="31"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="442"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="544"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="207"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="442"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="460"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00061758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00068988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00079611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM01313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005012547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="895" mass="102111" checksum="5BE39FFEA19E865D" modified="2022-01-19" version="1">MTAIKHALQRDIFTPNDERLLSIVNVCKAGKKKRNCFLCATVTTERPVQVNVVKVKKSDKGDFYKRQTAWALRDLAVVDAKDAVKENPEFDLHFDKVYKWVASSAVEKNTFISCIWKLNQRYLRKKIDFINVSSQLLEESVPSGENQSVAGGDEEAVDEYQELNAREEQDIEIMMEGCEYAISNAEAFAEKLSRELQVLDGANIQSIMASEKQVNILMKLLDEALKEVDQIELKLSSYEEMLQSVKEQMDQISESNHLIHLSNTNNVKLLSEIEFLVNHMDLAKGHIKALQEGDLTSSRGIEACTNAADALLQCMNVSLHPGHDMLHAVKQQQQRFSDLREQFARRLASHLNSVFVQQGHDQSSTLAQHSVELTLPNHHPFHRDLLRYAKLMEWLKNTDYGKYEGLTKNYMDYLSRLYEREIKDFFEVAKIKMTGTTKEGKKFATLPRKESAVKQETESLHGSSGKLTGSTSSLNKLSVQSSGNRRSQSSSLLDMGNMSASDLDVADRTKFDKIFEQVLSELEPLCLAEQDFISKFFKLQQHQSISGTTTNETEEMDGGNLSRSYISGVPQPVSSEKDMIRQMMTKIFRCIEPELNNLIALGDKIDSFNSLYMLVKMSHHVWTAQNVDPASFLSTTLGNVLVTVKRNFDKCISNQMKQMDEVKISKKSKVGILPFVAEFEEFAALAESIFKNAERRGDLDKAYIKLIRAVFISVEKVANESQKTPRDVVMMENFHHIFATLSRLKISCLEAEKKEAKLKYTEHLQSYVVYSLGQPLEKLNHFFEGVEARVAQGIREEEVSYQLAFNKQELRKVIKEYPGKEVKKGLDNLYKKVDKHLCEEENLLQVVWHSMQDEFIRQYKHFEGLIARCYPGSGITMEFTIQDILDYCSSIAQSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TID3</accession>
    <name>A0A8C2TID3_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F237A protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116653516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_032300988.1">
        <property type="nucleotide sequence ID" value="XM_032445097.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032300989.1">
        <property type="nucleotide sequence ID" value="XM_032445098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TID3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005018352.1">
        <property type="protein sequence ID" value="ENSCJPP00005012706.1"/>
        <property type="gene ID" value="ENSCJPG00005010796.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116653516"/>
    <dbReference type="KEGG" id="cjo:116653516"/>
    <dbReference type="GeneTree" id="ENSGT00390000015769"/>
    <dbReference type="OrthoDB" id="9931800at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040439">
        <property type="entry name" value="FAM237A/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36690">
        <property type="entry name" value="PROTEIN FAM237A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36690:SF2">
        <property type="entry name" value="PROTEIN FAM237A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034021810" description="F237A protein" evidence="1">
        <location>
            <begin position="35"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005012706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="185" mass="21358" checksum="35C9406032A67B66" modified="2022-01-19" version="1">MDFGNRGRIHCNMKLTYFLLVMGMFCLTPSLCHSQIDPLALGRADPQCWESSSAVLLEMRKPHISDSVSGFWDFMIFLKSSENLKHGALFWDLAQLFWDIYVDCVLSRTHGLGRRQLAEAQQRITTLASQFTGRNRGMFAHIQRSPVLRKRDLFEDLIKKHKHKSRSTLLGRIIGELGEKKKQHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TJ60</accession>
    <name>A0A8C2TJ60_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TJ60"/>
    <dbReference type="Ensembl" id="ENSCJPT00005020892.1">
        <property type="protein sequence ID" value="ENSCJPP00005014711.1"/>
        <property type="gene ID" value="ENSCJPG00005012251.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154136"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33332">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01345">
        <property type="entry name" value="CERVTRCPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005014711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="464" mass="51769" checksum="9EF2706F639FC240" modified="2022-01-19" version="1">METSMDVGGGIPVGDGAPISRGVPVGYGVPMVDGTSMMETSVGDGIPQCNGWISVGSGTPMGDGVIKNEHVIRGSQHSFTRGRSCLTNLVAFYDVVTALVDEGKATDVVYQDLSKAFDMVPHHILISKLEGSGFDGWTTRWISNWLKGHRQRVVVNGSMSRWRPVTSGVPQGSVLGPVLFNIFINDIDEGIECTLSKFADDTKLSGAVDTVEGTDAIQRDLDRLESWARVNLMRFNTAKCKVLHLGRKNPRHLYRLGGVVLESSSAEKDLGVLMDERLNMSQQCALAARKANGILGSIRRGVVSRDREVIVPLYSALVRPHLLYRVQVWSPQYKKDMEILERVQRRATKMIRGLEHLPYEDRLRELGLFSLEKRRLRGDLIAAFQYLKGTYSQEGSKLLERADNSRTRGNGFKLKEGRFRLDVRGKFFTRRVVRPWNRLPREVVDAPSLEVFKARLDGAMGNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TK41</accession>
    <name>A0A8C2TK41_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Family with sequence similarity 98 member A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FAM98A</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM98 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015713194.1">
        <property type="nucleotide sequence ID" value="XM_015857708.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TK41"/>
    <dbReference type="Ensembl" id="ENSCJPT00005019361.1">
        <property type="protein sequence ID" value="ENSCJPP00005013479.1"/>
        <property type="gene ID" value="ENSCJPG00005011373.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107311293"/>
    <dbReference type="KEGG" id="cjo:107311293"/>
    <dbReference type="CTD" id="25940"/>
    <dbReference type="GeneTree" id="ENSGT00440000037341"/>
    <dbReference type="OrthoDB" id="512356at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072669">
        <property type="term" value="C:tRNA-splicing ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032418">
        <property type="term" value="P:lysosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900029">
        <property type="term" value="P:positive regulation of ruffle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018797">
        <property type="entry name" value="FAM98"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31353">
        <property type="entry name" value="FAM98"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31353:SF9">
        <property type="entry name" value="PROTEIN FAM98A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10239">
        <property type="entry name" value="DUF2465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="300"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="465"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="302"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="331"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="351"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="408"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="468"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="485"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="512"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="530"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005013479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="544" mass="58035" checksum="090B2DE0739F3702" modified="2022-01-19" version="1">MEFELLESDVLESLEDLGYKGPLLDDGALAQAVSRGASSPEFTKLCAWLVSELRLFCKLEENVQATNSPNEAEEFQLEVSGLLAEMNCPYTSLTSGDVTKRLLNQKNCLLLLTYLISELEAARMLCVNAPPKKAQEGGGSEVFQELKGICIALGMSKPPANITMFQFFSGIEKKLKETLAKVPPNHVGKPLLKKQLGPAHWEKIEAINQAIVNEYEVRRKLLVKRLDVTVQSFGWSDRAKSQTEKLAKVYQPKRALLSTKCTISVANLLAARQDLSKIMRTSSGSIREKTACAINKVLMGRVPDRGGRPNEIEPPPPEMPPWQKRPEAGPQQGGGRGGRGGYESSYGGRGGYDHGGHSHGGHDRGGRGGHERGGHDQGGHDRGGRGGRGGYDHGGRGGGRGNKLQGGWTDGGGGGYQDGNYRDSNYRDAGFQTGGYHGGGGGYQGGGYGGYQSCSYTGSGYQGGGGYQQDNRYQDGGSHSDRGGGRGGGRGGRGGRGGRGGQGGGWGGRGGQNFNQGGQFEQHFQHGGYQYNQSGFGQGRHFTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TK59</accession>
    <name>A0A8C2TK59_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Double-stranded RNA-binding protein Staufen homolog 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">STAU2</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">RNA-binding protein required for the microtubule-dependent transport of neuronal RNA from the cell body to the dendrite. As protein synthesis occurs within the dendrite, the localization of specific mRNAs to dendrites may be a prerequisite for neurite outgrowth and plasticity at sites distant from the cell body.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015711265.1">
        <property type="nucleotide sequence ID" value="XM_015855779.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TK59"/>
    <dbReference type="Ensembl" id="ENSCJPT00005019984.1">
        <property type="protein sequence ID" value="ENSCJPP00005013965.1"/>
        <property type="gene ID" value="ENSCJPG00005011721.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107310280"/>
    <dbReference type="KEGG" id="cjo:107310280"/>
    <dbReference type="CTD" id="27067"/>
    <dbReference type="GeneTree" id="ENSGT00940000154977"/>
    <dbReference type="OrthoDB" id="10037267at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032839">
        <property type="term" value="C:dendrite cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098964">
        <property type="term" value="P:anterograde dendritic transport of messenger ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007281">
        <property type="term" value="P:germ cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008298">
        <property type="term" value="P:intracellular mRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035418">
        <property type="term" value="P:protein localization to synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19880">
        <property type="entry name" value="DSRM_STAU2_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19882">
        <property type="entry name" value="DSRM_STAU2_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19884">
        <property type="entry name" value="DSRM_STAU2_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19886">
        <property type="entry name" value="DSRM_STAU2_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19888">
        <property type="entry name" value="DSRM_STAU2_rpt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000007">
        <property type="entry name" value="Double-stranded RNA-binding protein Staufen homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000024">
        <property type="entry name" value="double-stranded RNA-binding protein Staufen homolog 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000057">
        <property type="entry name" value="Double-stranded RNA-binding protein Staufen homolog 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000013">
        <property type="entry name" value="double-stranded RNA-binding protein Staufen homolog 2 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051740">
        <property type="entry name" value="DRBM-containing_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044476">
        <property type="entry name" value="STAU2_DSRM_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044464">
        <property type="entry name" value="STAU2_DSRM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044473">
        <property type="entry name" value="STAU2_DSRM_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044474">
        <property type="entry name" value="STAU2_DSRM_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032478">
        <property type="entry name" value="Staufen_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46054:SF1">
        <property type="entry name" value="DOUBLE-STRANDED RNA-BINDING PROTEIN STAUFEN HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46054">
        <property type="entry name" value="MATERNAL EFFECT PROTEIN STAUFEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16482">
        <property type="entry name" value="Staufen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DRBM" evidence="16">
        <location>
            <begin position="80"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="16">
        <location>
            <begin position="167"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="16">
        <location>
            <begin position="279"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="16">
        <location>
            <begin position="379"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="43"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="127"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="266"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00060168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005013965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="680" mass="74075" checksum="26BAC2ECC4276897" modified="2022-01-19" version="1">MAQVKMQTTANLSGPPMSPMVLPLPVTAANTLGLPPAMNGSIPESAASCSSPTAGLADPTPASNPPAPLQDNMANPKEKTPMCLVNELARFNRIQPQYKLLNERGPAHAKMFTVQLTLGEQTWEAEGSSIKKAQHAAASKALNETTLPKPTPRPPKNNVNNNPGSITPTVELNGLAMKRGEPAIYRPLDPKPIPNYRANYNFRGMYNQRYHCPVPKIFYVQLTVGNSEFFGEGKTRQAARHNAAMKALQALQNEPIPEKLPQNGETGKETEEDKDANKSEISVVFEIALKRNIPVSFEVIKESGPPHMKSFVTRVTVGEFMGEGEGKSKKLSKKRAAMSVLQELKKLPPLPVIEKPKLYFKKRPKTILKTGPEYGQGMNPISRLAQIQQAKKEKEPEYVLLSERGMPRRREFVMQVKVGNEITTGTGPNKKIAKRNAAEAMLLQLGYKASTPLQDQTEKLGENKSWNGQNVGFPEPTSSTPKGILHLSPDVYQEMEASRNKSAPGTTVSYLSPKEMSQTSSSFFSISPTTNSTATIARELLMNGTSPTAEAIGLKGISPASPCSAVQPSKQLEYLARIQGFQVHYSDRQNGKECMTCLTLSPVQMTFQGIGSSIEASRDQAALSALKQFSEQGLDPVEGTLKVENGSLEKQVKHLGEKADNKQTNSGTIAQDCKDSKAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TKS8</accession>
    <name>A0A8C2TKS8_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transmembrane serine protease 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">TMPRSS13</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TKS8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005019710.1">
        <property type="protein sequence ID" value="ENSCJPP00005013755.1"/>
        <property type="gene ID" value="ENSCJPG00005011553.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159197"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000003">
        <property type="entry name" value="Transmembrane serine protease 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF27">
        <property type="entry name" value="TRANSMEMBRANE PROTEASE SERINE 3-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15494">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 7" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="10">
        <location>
            <begin position="153"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="9">
        <location>
            <begin position="231"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="210"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005013755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="484" mass="53463" checksum="2333BE666B399CAD" modified="2022-01-19" version="1">MTVVCALGSAHSWSLPERGWKEKIDPCARCWQKGGIPWGCEGRAAHAEVRGRVWVPRGGCAPPDSAPIPLPGSSMFRAACMSQRRLALIFCVSVLIVLIVALILLFMFWRSQTGIVYKEPAETCKDNPVRCDGVVDCSQRSDELGCVRFSSDQSLLHVYSSAESQWLPVCSSAWDESFSRKTCRQLGFQKAGGWAGADVCPPLLSHSSQCPTGKFVSLRCTTCGQRISGRIIGGKETSVSKWPWQVSVQYGPVHICGGTIIDAQWVLTAAHCFFMNSMKILDDWKVYGGVSDLKQPMEGIPVSQVIINSNYSDDHDDYDIALMKLSRPLTLSAQIRPACLPMHGQRFQTGRSCFITGFGKTRENEDNTSPKLREAEVKLIDYKICNSDKVYEGYLTPRMMCAGYLQGGKDACQGDSGGPLVCEDNGRWYVAGVTSWGTGCGQKNKPGVYTRVTKLLSWIYSKMEVRIRKSLHMFSGLVLTSREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TKV1</accession>
    <name>A0A8C2TKV1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">TRAF3-interacting protein 1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Cilium axoneme</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TRAF3IP1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TKV1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005021885.1">
        <property type="protein sequence ID" value="ENSCJPP00005015431.1"/>
        <property type="gene ID" value="ENSCJPG00005012795.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000178952"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042073">
        <property type="term" value="P:intraciliary transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070507">
        <property type="term" value="P:regulation of microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.50">
        <property type="entry name" value="Microtubule-binding protein MIP-T3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018799">
        <property type="entry name" value="TRAF3IP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040468">
        <property type="entry name" value="TRAF3IP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042576">
        <property type="entry name" value="TRAF3IP1_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31363">
        <property type="entry name" value="TRAF3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31363:SF0">
        <property type="entry name" value="TRAF3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10243">
        <property type="entry name" value="MIP-T3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRAF3-interacting protein 1 N-terminal" evidence="9">
        <location>
            <begin position="5"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="55" mass="6106" checksum="B59AD1B3C35BA238" modified="2022-01-19" version="1">MNEAVVRRTQESLGRVIRKPPLTERLLSKPPFRYLHDVITEVGLPAGGARRVGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TL16</accession>
    <name>A0A8C2TL16_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitochondrial coenzyme A transporter SLC25A42</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Solute carrier family 25 member 42</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">SLC25A42</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Mitochondrial carrier mediating the transport of coenzyme A (CoA) in mitochondria in exchange for intramitochondrial (deoxy)adenine nucleotides and adenosine 3',5'-diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>3'-dephospho-CoA(in) + ADP(out) = 3'-dephospho-CoA(out) + ADP(in)</text>
            <dbReference type="Rhea" id="RHEA:72843"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ADP(in) + ATP(out) = ADP(out) + ATP(in)</text>
            <dbReference type="Rhea" id="RHEA:34999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ADP(out) + CoA(in) = ADP(in) + CoA(out)</text>
            <dbReference type="Rhea" id="RHEA:72839"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>AMP(in) + ADP(out) = AMP(out) + ADP(in)</text>
            <dbReference type="Rhea" id="RHEA:72851"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>adenosine 3',5'-bisphosphate(in) + ADP(out) = adenosine 3',5'-bisphosphate(out) + ADP(in)</text>
            <dbReference type="Rhea" id="RHEA:72847"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>dADP(in) + ADP(out) = dADP(out) + ADP(in)</text>
            <dbReference type="Rhea" id="RHEA:72855"/>
            <dbReference type="ChEBI" id="CHEBI:57667"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 20">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TL16"/>
    <dbReference type="Ensembl" id="ENSCJPT00005019072.1">
        <property type="protein sequence ID" value="ENSCJPP00005013242.1"/>
        <property type="gene ID" value="ENSCJPG00005011178.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158163"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043262">
        <property type="term" value="F:ADP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015217">
        <property type="term" value="F:ADP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080122">
        <property type="term" value="F:AMP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005347">
        <property type="term" value="F:ATP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015228">
        <property type="term" value="F:coenzyme A transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000014">
        <property type="entry name" value="mitochondrial coenzyme A transporter SLC25A42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002167">
        <property type="entry name" value="GDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00928">
        <property type="entry name" value="GRAVESDC"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 19 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 20" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="19">
        <location>
            <begin position="28"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="19">
        <location>
            <begin position="126"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="19">
        <location>
            <begin position="221"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00036145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00036693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00036979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00040682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00041886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00052420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005013242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="321" mass="35713" checksum="59042E8662E07721" modified="2022-01-19" version="1">MGNGVRKGQVDIKGQDVDALFQGVQEQKKVLNSLMSGALAGAVAKTAVAPLDRTKIMFQVSSKRFSAKEAYRLIYRTYLNEGFWSLWRGNSATMVRVIPYAAIQFCAHEEYKQLLGSYYGFQGKALTPFPRFIAGSLAGTTAAMLTYPLDMVRARMAVTPKEMYSNIVHVFIRISREEGLKTLYRGFTPTILGVIPYAGLSFFTYETLKKLHADHSGKSQPSPPERLLFGACAGLIGQSASYPLDVVRRRMQTAGVMGHTYSSILLTMQEIIREEGLIRGLYKGLSMNWVKGPIAVGISFTTFDLTQILLRKLQHSTNVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TL91</accession>
    <name>A0A8C2TL91_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Copine-2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Copine II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">CPNE2</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Exhibits calcium-dependent cell membrane binding properties.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the copine family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015729183.1">
        <property type="nucleotide sequence ID" value="XM_015873697.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TL91"/>
    <dbReference type="Ensembl" id="ENSCJPT00005020484.1">
        <property type="protein sequence ID" value="ENSCJPP00005014382.1"/>
        <property type="gene ID" value="ENSCJPG00005012015.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107319103"/>
    <dbReference type="CTD" id="221184"/>
    <dbReference type="GeneTree" id="ENSGT00940000157653"/>
    <dbReference type="OrthoDB" id="5855668at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071277">
        <property type="term" value="P:cellular response to calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd04048">
        <property type="entry name" value="C2A_Copine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04047">
        <property type="entry name" value="C2B_Copine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000103">
        <property type="entry name" value="Copine 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000042">
        <property type="entry name" value="Copine 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037768">
        <property type="entry name" value="C2B_Copine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045052">
        <property type="entry name" value="Copine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010734">
        <property type="entry name" value="Copine_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10857">
        <property type="entry name" value="COPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10857:SF3">
        <property type="entry name" value="COPINE-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07002">
        <property type="entry name" value="Copine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="C2" evidence="15">
        <location>
            <begin position="7"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="15">
        <location>
            <begin position="134"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00053843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00074827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00081783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005014382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="544" mass="60688" checksum="A019F41C91E8839C" modified="2022-01-19" version="1">MAYTGTPPPVGPIGSQYCVCKVELSICGQNLLDRDVTSKSDPFCVLFMEVNGKWVELDRTETAVNNLNPAFSKKFVVDYHFEEVQKLKFALFDQDKSSTQLYEHDFLGEFSCTLGTIVSSKKITRTLLLGNGKPAGKGMITIAAQELSDNRVITLSMAGRKLDKKDLFGKSDPFLEFYKLGDDGKWMLVHRTEVIKYTLDPVWKPFTVPLVSLCDGDVEKLIKVMCYDYDSDGGHDFIGEFQTSVARMCEAQDAFPLELECINPKKQKKKKNYKNSGIIIVKSCKITRDFSFLDYILGGCQLMFTVGIDFTASNGNPRDPSSLHYINPMGTNEYLSAIWAVGQIIQDYDSDKMFPALGFGAQLPPDWKVSHEFAINFNPTNPFCSGVEGIVQAYSACLPHIRFYGPTNFSPIVNHVARFAAQATQQEAASQYFILLIITDGVISDMDETRHAVVQAAKLPMSIIIVGVGNADFAAMEFLDGDSRVLRSHTGEEAVRDIVQFVPFRDFRNAPKETLAKAVLAELPQQVVQYFKHQNLPPINLEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TM06</accession>
    <name>A0A8C2TM06_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">26S proteasome complex subunit SEM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">SEM1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the DSS1/SEM1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TM06"/>
    <dbReference type="Ensembl" id="ENSCJPT00005019608.1">
        <property type="protein sequence ID" value="ENSCJPP00005013678.1"/>
        <property type="gene ID" value="ENSCJPG00005011510.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163409"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13768">
        <property type="entry name" value="DSS1_Sem1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007834">
        <property type="entry name" value="DSS1_SEM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16771">
        <property type="entry name" value="26 PROTEASOME COMPLEX SUBUNIT DSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16771:SF0">
        <property type="entry name" value="26S PROTEASOME COMPLEX SUBUNIT SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05160">
        <property type="entry name" value="DSS1_SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01385">
        <property type="entry name" value="DSS1_SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU369057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005013678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="143" mass="16506" checksum="80DEF033B03C1023" modified="2022-01-19" version="1">MRRRSVGRAVPCRHPVSVGGQRGRACRRKSNRWIWGSWRRTTSSRSFRLKVQDTSREGAAGVWASAKQPEGLSQLWTLGGPCLVLYPQFWQLSRVVNGDWTGLDEDEDAHVWEDNWDDDNVEDDFSNQLRAELEKHGYKMETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TN60</accession>
    <name>A0A8C2TN60_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Transient receptor potential cation channel subfamily M member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">TRPM1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Mg(2+)(in) = Mg(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29827"/>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_032302764.1">
        <property type="nucleotide sequence ID" value="XM_032446873.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005021717.1">
        <property type="protein sequence ID" value="ENSCJPP00005015297.1"/>
        <property type="gene ID" value="ENSCJPG00005012693.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107318642"/>
    <dbReference type="CTD" id="4308"/>
    <dbReference type="GeneTree" id="ENSGT00940000155024"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071482">
        <property type="term" value="P:cellular response to light stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007216">
        <property type="term" value="P:G protein-coupled glutamate receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051262">
        <property type="term" value="P:protein tetramerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1010">
        <property type="entry name" value="TRPM, tetramerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050927">
        <property type="entry name" value="TRPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057366">
        <property type="entry name" value="TRPM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041491">
        <property type="entry name" value="TRPM_SLOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032415">
        <property type="entry name" value="TRPM_tetra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037162">
        <property type="entry name" value="TRPM_tetra_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13800:SF13">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13800">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18139">
        <property type="entry name" value="LSDAT_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25508">
        <property type="entry name" value="TRPM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16519">
        <property type="entry name" value="TRPM_tetra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="852"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="919"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="949"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="988"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1068"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1115"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="domain" description="TRPM SLOG" evidence="13">
        <location>
            <begin position="92"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="TRPM-like" evidence="14">
        <location>
            <begin position="481"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="11">
        <location>
            <begin position="859"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="domain" description="TRPM tetramerisation" evidence="12">
        <location>
            <begin position="1192"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="40"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="426"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="596"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="797"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1307"/>
            <end position="1326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1565"/>
            <end position="1596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="448"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="799"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="819"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1571"/>
            <end position="1584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF18139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF25508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1626" mass="184575" checksum="9215F0D1FAB625A6" modified="2022-01-19" version="1">MGQKAWIEKTFSKRECIYVIANNKDISRCCCGQLINQHIPPPPSTTANKNGEETKQVEAQPEKWSVSKHTQTYPTDAYGNLEFQGGGHSNKAMYIRVSYDTKPDSLLHLMVKDWQLELPKLLISVHGGLQNFEMQPKLKQVFGKGLIKAAMTTGAWIFTGGVSTGVIRHVGDALKDHSSKSRGRICAIGIAPWGIVENKEDLIGKDVTRVYQTMSNPLSKLSVLNSSHTHFILADNGTLGKYGAEVKLRRQLEKHISLQKINTRLGQGVPVVALIVEGGPNVISIVLECLREEPPLPVVICDGSGRASDILSFAHKYSEEGGIISESLRDQLLVTIQKTFNYSRNQAHQLFVILMECMKKKELITVFRMGSEGQQDIEMSILTALLKGTNASAPDQLSLALAWNRVDIARSQIFVFGHHWPPLGSLTASDGTAPEKEKKSPAVQTKAARGKGKGKKKGGKVKEEPEEETDPRKLELLNWVNSLEQAMLDALVLDRVDFVKLLIENGVNMQHFLTIPRLEELYNTRLGPPNTLHLLVRDVKKGNLPPDYHISLIDIGLVLEYLMGGAYRCNYTRKSFRTLYNNLFGPKRPKALKLLGMEDDEPPTKGKKKKKKKEEEIDIDVDDPEVSRFQYPFHELMLWAVLMKRQKMALFLWQRGEETMAKALVACKLYKSMAHESSESELVDDISQDLDNNSKDFGQLAVELLDQSYKHDEQIAMKLLTYELKNWSNSTCLKLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNPGLKVIMGILFPPTILFLEFRSYDDYSYQTSRDNEEGKEKEEENADANVDTGSRKGDEENGNKKQNSLPIGTKIYEFYNAPIVKFWFYTISYLGYLMLFNYIILVRMERWPSVQEWIVISYIVTLALEKVREILMSEPGKLSQKVKVWLQEYWNITDLVAISVFMIGAILRLQNQPYMGYGRVIYCVDIIFWYIRVLDIFGVNKYLGPYVMMIGKMMIDMLYFVVIMLVVLMSFGVARQAILHPDEEPSWRLARNIFYMPYWMIYGEVFADQIDPPCGDNLYDEDGKRLPPCIPGAWLTPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHDRPVLPPPMIIFSHLYIIIKRICCRCKKREGDQDERDRGLKLFLNDEELKKLYEFEEQCVEEYFQEKEDEQQSSNDERIRVTSERVENMSMRLEEVNEREHFMKASLQTVDLRLSQLEELSGRMVNALEKMAGVDKSELTYTRSRASSECDAAYLLRQSSVNSSDGYSMYRYHVGGDELAFDDGTTPMSPAIGSRKKVHSVGTKEDGADPKMLVPEHHTSLHYTSNANAVTPADYSTSALDVAQNISSPHSGSGALGDENQGILKKDEIAPQSLNRMDVIMNRQSVPRSDLQNTQLKVERTKLEATISYPLDKSKAMRYFPPETFSACQTTMMKSRSFIFAQGGKLVGGVNNWTTEYSTIMDQVCPSTIEQWATEWKYEVEQQLSQERPPEYPGIISEAEKQAEQKQLHMDTDDDSDVGEAGLSASYASMPATVKTQTENLLSVKPERTSGFRSVRSKSLHSHSRKAKTIKDKLNRPGHASSVTNLVVAFGSATEEQKARQENASTETEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TNF4</accession>
    <name>A0A8C2TNF4_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cyclin B2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">CCNB2</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Essential for the control of the cell cycle at the G2/M (mitosis) transition.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclin family. Cyclin AB subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015727897.1">
        <property type="nucleotide sequence ID" value="XM_015872411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TNF4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005021756.1">
        <property type="protein sequence ID" value="ENSCJPP00005015330.1"/>
        <property type="gene ID" value="ENSCJPG00005012721.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107318514"/>
    <dbReference type="KEGG" id="cjo:107318514"/>
    <dbReference type="CTD" id="9133"/>
    <dbReference type="GeneTree" id="ENSGT00940000155405"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008315">
        <property type="term" value="P:G2/MI transition of meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044772">
        <property type="term" value="P:mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040008">
        <property type="term" value="P:regulation of growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007057">
        <property type="term" value="P:spindle assembly involved in female meiosis I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043029">
        <property type="term" value="P:T cell homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048538">
        <property type="term" value="P:thymus development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd20566">
        <property type="entry name" value="CYCLIN_CCNB2_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20570">
        <property type="entry name" value="CYCLIN_CCNB2_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000027">
        <property type="entry name" value="G2/mitotic-specific cyclin-B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046965">
        <property type="entry name" value="Cyclin_A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001771">
        <property type="entry name" value="Cyclin_A_B_D_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5 7" id="KW-0195">Cyclin</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="9">
        <location>
            <begin position="176"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="10">
        <location>
            <begin position="269"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="9">
        <location>
            <begin position="273"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="402" mass="45049" checksum="E93A779F7642B66D" modified="2022-01-19" version="1">MAVTRRAAVMRGMENAVTGHNNKAKVQVTGKRAVLEEIGNKVTRGSTLPKKTDCIKPPVKATKGPGKMTNTVVPPKPPAAVNQAVKDTTTIAAKVLSPVPMDVSMQEEDLCLAFSDVLLHNIEDIDADDSGNPQLCSDYVKDIYLYLRQLELQQSVRPHYLEGRTINGRMRAILVDWLVQVHSRFQLLQETLYMCVGVMDRFLQNHPVPRKRLQLVGVTALLLASKYEEMYSPDVADFVYITDNTYSSADVREMEITILKELNFDLGRPLPLHFLRRASKAGEADAEQHTLAKYLMELTLIDYDMVHYHPSEIAAAALCLSQKVLGHDKWGTKQQYYTGYAEDSLTMTMKHMAKNVVKVNENLTKYTAVRNKYASSKLLKISTIPQLKCNAIKDLAASLLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TP30</accession>
    <name>A0A8C2TP30_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal L1 domain containing 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">RSL1D1</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TP30"/>
    <dbReference type="Ensembl" id="ENSCJPT00005023068.1">
        <property type="protein sequence ID" value="ENSCJPP00005016396.1"/>
        <property type="gene ID" value="ENSCJPG00005013481.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00440000038603"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048027">
        <property type="term" value="F:mRNA 5'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000772">
        <property type="term" value="P:regulation of cellular senescence"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032880">
        <property type="term" value="P:regulation of protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005016396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="349" mass="39430" checksum="FEE7C1D8BE2284FF" modified="2025-10-08" version="2">MVTVWKIPRVAQVIKIPLPHGIRAETAEVCLFTKDEPDLTAEQTESLYRKLLTQNGITSVSQVISYKTLKKEYKPFEAKRRLLNRFDLFLSDDRIRRLLPSHLGKHFYEKKKAPLAVNLKAKNLAKELQKHVQGTVLPVTNKGCCYTTRIGHTGMKADEILENIIAAAEVIARKLPQNWRNVKVLHLKTLKSVALPIFTARISSLDEIDKEPIANKKQGEVTSKKIKIFYKATSSLAKAEPSQSPERGDNLGNKTKAVLGKRKKQFLAPETSKQKIIEEQVDLQMSSEQKKTTQLSMAKEEIKELEKTPKKPEAKSFATRNAGKLVQSSKKSSKTPKRTAKKVRRPQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TP98</accession>
    <name>A0A8C2TP98_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleolar protein 12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">NOL12</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP17 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015718348.1">
        <property type="nucleotide sequence ID" value="XM_015862862.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TP98"/>
    <dbReference type="Ensembl" id="ENSCJPT00005023324.1">
        <property type="protein sequence ID" value="ENSCJPP00005016614.1"/>
        <property type="gene ID" value="ENSCJPG00005013637.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107314013"/>
    <dbReference type="KEGG" id="cjo:107314013"/>
    <dbReference type="CTD" id="79159"/>
    <dbReference type="GeneTree" id="ENSGT00390000015973"/>
    <dbReference type="OrthoDB" id="551633at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019186">
        <property type="entry name" value="Nucleolar_protein_12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14577">
        <property type="entry name" value="NUCLEOLAR PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14577:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09805">
        <property type="entry name" value="Nop25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="122"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="35"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="127"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="169"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005016614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="215" mass="25006" checksum="E94270465273AFC2" modified="2022-01-19" version="1">MGRKKKKKGSGSAASRLVVTFDEEKRREYLTGFHKRKVERRKVALEEIKRKLKEEQRKMKEERHKEYLKMLREREEALDEFDELEHLVTSRTESVNIDHPNHIVTVTTISDLDLSGARQLGLTTSEGKSDASEEKGEEVMNKPASTVPKKSRNPFLSEKISSLTATLHMHSRKKKKGKQPQRGQGPFKKIQKPNMRRTTKTQRRRLTGRMGRDQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TPU0</accession>
    <name>A0A8C2TPU0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">DNA damage-binding protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 6">Damage-specific DNA-binding protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">DDB1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of complexes involved in DNA repair and protein ubiquitination. May play a role in the regulation of the circadian clock.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the UV-DDB complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">The core of the protein consists of three WD40 beta-propeller domains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DDB1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TPU0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005022540.1">
        <property type="protein sequence ID" value="ENSCJPP00005015983.1"/>
        <property type="gene ID" value="ENSCJPG00005013182.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183151"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031464">
        <property type="term" value="C:Cul4A-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031465">
        <property type="term" value="C:Cul4B-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160072">
        <property type="term" value="F:ubiquitin ligase complex scaffold activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071987">
        <property type="term" value="F:WD40-repeat domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097510">
        <property type="term" value="P:base-excision repair, AP site formation via deaminated base removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051702">
        <property type="term" value="P:biological process involved in interaction with symbiont"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035234">
        <property type="term" value="P:ectopic germ cell programmed cell death"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044725">
        <property type="term" value="P:epigenetic programming in the zygotic pronuclei"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051093">
        <property type="term" value="P:negative regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051898">
        <property type="term" value="P:negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000242">
        <property type="term" value="P:negative regulation of reproductive process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046726">
        <property type="term" value="P:positive regulation by virus of viral protein levels in host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045722">
        <property type="term" value="P:positive regulation of gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045732">
        <property type="term" value="P:positive regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045070">
        <property type="term" value="P:positive regulation of viral genome replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042752">
        <property type="term" value="P:regulation of circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901990">
        <property type="term" value="P:regulation of mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007056">
        <property type="term" value="P:spindle assembly involved in female meiosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060337">
        <property type="term" value="P:type I interferon-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019076">
        <property type="term" value="P:viral release from host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000070">
        <property type="entry name" value="DNA damage-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:002576">
        <property type="entry name" value="DNA damage-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="8">
        <location>
            <begin position="15"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="9">
        <location>
            <begin position="396"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="7">
        <location>
            <begin position="790"/>
            <end position="1075"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007453"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00014577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368023"/>
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    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
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    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015983.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1089" mass="120848" checksum="A7011A73EECF238D" modified="2022-01-19" version="1">MSYNYVVTAQKPTAVNGCVTGHFTSAEDLNLLIAKNTRLEIYVVTAEGLRPVKEVGMYGKTAVMELFRPKGESKDLLFILTAKYNACILEYKQNGDNIDIITRAHGNVQDRIGRPSETGIIGIIDPECRMIGLRLYDGLFKVIPLDRENKELKAFNIRLEELQVIDVKFLYGCQAPTICFVYQDPQGRHVKTYEVSLREKEFNKGPWKQENVEAEASMVIAVPEPFGGAIIIGQESITYHNGDKYLAIAPPIIKQSTIVCHNRVDPNGSRYLLGDMEGRLFMLLLEKEEQMDGTVTLKDLRVELLGETSIAECLTYLDNGVVFVGSRLGDSQLVKLNVDSNEQGSYVVAMETFTNLGPIVDMCVVDLERQGQGQLVTCSGAFKEGSLRIIRNGIGIHEHASIDLPGIKGLWPLRSDSHREMDNMLVLSFVGQTRVLMLNGEEVEETELTGFVDDQQTFFCGNVAHQQLIQITSASVRLVSQEPKALMSEWKEPNGKNISVASCNSNQVVVAVGRALYYLEIRPQELRQINCTEMEHEVACLDITPLGDTNGMSPLCAIGLWTDISARILKLPSFELLHKEMLGGEIIPRSILMTTFESSHYLLCALGDGALFYFGLSLETGLLSDRKKVTLGTQPTVLRTFRSLSTTNVFACSDRPTVIYSSNHKLVFSNVNLKEVNYMCPLNSDGYPDSLALANNSTLTIGTIDEIQKLHIRTVPLYESPRKICYQEVSQCFGVLSSRIEVQDASGGTTALRPSASTQALSSSVSTSKLFSSSTAPHETSFGEEVEVHNLLIIDQHTFEVLHAHQFLQNEYALSLVSCKLGKDPNTYFIVGTAMVYPEEAEPKQGRIVVFHYSDGKLQSLAEKEVKGAVYSMVEFNGKLLASINSTVRLYEWTAEKELRTECNHYNNIMALYLKTKGDFILVGDLMRSVLLLAYKPMEGNFEEIARDFNPNWMSAVEILDDDNFLGAENAFNLFVCQKDSAATTDEERQHLQEVGLSHLGEFVNVFCHGSLVMQNLGETSTPTQGSVLFGTVNGMIGLVTSLSESWYNLLLDMQNRLNKVIKSVGKIEHSLYPSVVQLGAIAGGCFVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TQC5</accession>
    <name>A0A8C2TQC5_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Myotubularin related protein 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">MTMR11</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TQC5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005023872.1">
        <property type="protein sequence ID" value="ENSCJPP00005017082.1"/>
        <property type="gene ID" value="ENSCJPG00005013981.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160276"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022587">
        <property type="entry name" value="MTMR12-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030564">
        <property type="entry name" value="Myotubularin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010569">
        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807">
        <property type="entry name" value="MYOTUBULARIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807:SF51">
        <property type="entry name" value="MYOTUBULARIN-RELATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12578">
        <property type="entry name" value="3-PAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06602">
        <property type="entry name" value="Myotub-related"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51339">
        <property type="entry name" value="PPASE_MYOTUBULARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myotubularin phosphatase" evidence="2">
        <location>
            <begin position="19"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005017082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="533" mass="59597" checksum="305AF6FEC8130EF3" modified="2022-01-19" version="1">MGDEDEEDEEEGSPPTLLFETLQDWERELQRLGAAGWRVSAVNERFDMAPSLPRYLWVPNALLDHDLKRTFAHFQERRVARLCWHHPNGSDLLRAASFHAASEPGSEDIRCLEVLLGAGCRPCVLADTAELPTPQDIQLAHLRLRALCLPGAAADEKWLSALEGTRWLEHVRSCLRKAVEVASLLAGRRCSVVLQEPSDRDLGCLLASLVQLLLDPHSRSLHGFQSLIQREWVAMGHPFPQRLGLHRDSPREESPVFLLFLDCTWQLLQQFPAAFGFTEAYLLALHDSTFLPYCSTFLFSCQRQRGRGGVQQPRTQTYTPVSGRWDPPPGSSVCRLPPIWAWGLRYSRQQRARFRNPAWDPGPLGTPDDVDPQNTPPNTWLGSSSGAVLALSKGSLTPQPFPWRSGRPPPRLLRWAPSLETLIDRGGDPIPAPPRGLLLPCAAGPSVRLWRRCYLRGLPEAQVMGLGDPRPLVSILIPCTSSPTLHIYPTLYVHPNPTFIHPNPICVHPNPICVHPNPKCVHPNPIYAHPTPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TRV2</accession>
    <name>A0A8C2TRV2_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Unc-80 homolog, NALCN channel complex subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">UNC80</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015723428.1">
        <property type="nucleotide sequence ID" value="XM_015867942.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005023615.1">
        <property type="protein sequence ID" value="ENSCJPP00005016883.1"/>
        <property type="gene ID" value="ENSCJPG00005013837.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107316455"/>
    <dbReference type="CTD" id="285175"/>
    <dbReference type="GeneTree" id="ENSGT00640000091496"/>
    <dbReference type="OrthoDB" id="5584001at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034706">
        <property type="term" value="C:sodium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005261">
        <property type="term" value="F:monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055080">
        <property type="term" value="P:monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046460">
        <property type="entry name" value="UNC80_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045852">
        <property type="entry name" value="UNC80_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031542">
        <property type="entry name" value="UNC80_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31781:SF1">
        <property type="entry name" value="PROTEIN UNC-80 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31781">
        <property type="entry name" value="UNC80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19424">
        <property type="entry name" value="UNC80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20262">
        <property type="entry name" value="UNC80_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15778">
        <property type="entry name" value="UNC80_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cation channel complex component UNC80 N-terminal" evidence="2">
        <location>
            <begin position="17"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Protein UNC80 central region" evidence="3">
        <location>
            <begin position="1165"/>
            <end position="1839"/>
        </location>
    </feature>
    <feature type="domain" description="Protein UNC80 C-terminal" evidence="4">
        <location>
            <begin position="1883"/>
            <end position="2970"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="447"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="541"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="695"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="728"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="986"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1030"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1399"/>
            <end position="1420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1457"/>
            <end position="1506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1828"/>
            <end position="1863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1878"/>
            <end position="1897"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3003"/>
            <end position="3044"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3071"/>
            <end position="3267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="551"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="699"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="737"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="764"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1031"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1847"/>
            <end position="1861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="3003"/>
            <end position="3025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="3091"/>
            <end position="3107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="3108"/>
            <end position="3119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="3120"/>
            <end position="3129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="3196"/>
            <end position="3221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="3229"/>
            <end position="3238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="3240"/>
            <end position="3250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="3254"/>
            <end position="3265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005016883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="3322" mass="371226" checksum="21C2938FFDF6E5CF" modified="2022-01-19" version="1">MVKRKSSEGQEQESGRGIPLPIQTFLWRQTSAFLRPKLGKQYEASCVSFERVLVENKLHGLSPALSEAIQSISRWELVQAALPHVLHCTATLLSNRNKLGHQDKLGVAETKLLHTLHWMLLEAPQDCSNDRFGGDRGSSWGGSSSAFIHQAENQGSPGQPRPSTTNDEEENNRRKFFQNSMATVELFVFLFAPLVHRIKESDLTFRLASGLVIWQPMWEHRQPEVSAFNALVKPIRNIVTAKRSSPTNNQSVACESPNLDSGHTEGLQVVCETTLPDSVPPKPTVSACHRGNSLEGSVSSQTSQERGTPHPRVSVVIPPCQKSRYATYFDVAVLRCLLQPHWSEEGTQWSLMYYLQRLRHMLQEKPEKPPEPEITPLPRLRSSSMVAAAPSLVNTHKTQDLTMKCNEEEKSLSTEAFSKVSLTNLRRPAVPDLSTDLGMNIFKKFKSRKEDRERERKGSIPFHHTGKKRQRRMGMPFLLHEDHLDVSPTRSTFSFGSFSGIGEDRRGIERGGWQTTILGKFTRRGSSDTATEMESLSARHSHSHHTLVSDLPDHSNSHGENTVKEVRSQISTITVATFNTTLASFNVGYADFFSEHMRKLCNQVPIPEMPHEPLACANLPRSLTDSCINYSCLEDTDHIDGTNNFVHKNGMLDLSVVLKAVYLVLNHDISSRICDVALNIVECLLQLGVVPSVEKVRRKSENKENEAPEKRPNEGSFQLKASAGSACGFGPPPVSGTGDGGEEGGGGSGGGGSDGGGGGGGPYEKNDKKQEKDEGPSISTHRLALTMLIKIVKSLGCAYGCGEGHRGLSGDRLRHQVFRENAQNCLTKLYKLARMQFRQTMRDYVNRDSLNNVVDFLHALLGFCMEPVTDNKAGFGNNFTTVDNKSTAQNVEGIIVSAMFKSLITRCASTTHELHSPENLGLYCDIRQLVQFIKEAHGNVFRRVALSALLDSAEKLIPGKKTEETEQELKSCGSKRSEMGSVIIDKGQASAAPDECRSYVSSRPMQTPEHDEQNQGAVLGRKDFWRKMFKSQSAASDTSSQSEQDTSECTTAHSGTTTDRRSRSRSRRISLRKKLKLPIGNWLKRSSLSGLADGVEDLLDISSVDRLSFIRQSSKVKFTSAVKLSEGGGPGGGLDNGRDEEENFFKRLGCHSFDDHMTSNQEGGKSKNVVNLGAIRQGMKRFQFLLNCCEPGTIPDASILAAALDLEAPVVARAALFLECARFVHRCNRGNWPEWMKGHHVNITKKGLSRGRSPIVGNKRNQKLQWNAAKLFYQWGDAIGVRLNELCHAESESPANLLGLIYDEETKRRLRKEDEEEDFLDDSTVNPTKCCCPFALKMAACQLLLEITTFLRETFPYMPRPRPEPLVDLESCRLRLDPEMDRHRYERKISFAGVLDENEDSKDSLHSSSHTLKSEAGFEEKKVPSRRIRIGGSRLLQIKGTRSFRVKKGGSLSSIRRAGSLKSTKLSRQDSESENEDLQLSHSRDTVTDIEGSPWSASEPSIEPEVLSSTGTEENYHRNMSWLHVMILLCNQQSFICTHIDYCHPHCYLHHSRSCARLVRAIKLLYGDTVDSLRENSTLNSVARGKKQKECSDKSCLRTPSLKKRVVDINLEGKKDSGMLKYIRHQVMSLSPAPLSLLIKAAPVLTEEMYGDIHPAAWELLLSVDEHMAGAAAAMFLLCAVKVPEAVSDMLMSEFHHPETVQRLNAILKFHTLWRFRYQVWPRMEEGAQQIFKIPPPSINFTLPSPVLGMPSVPMFDPPWVPQCSGSVQDPINEDQSKSFSARAVSRSHQRAEHILKNLQQEEEKKRLGREASLITAIPITQEACYEPTCTPSSEQEEEEEVANLASRRLSVSPSCTSSTSHRNYSFRRGSVWSVRSAVSAEDEEHTTEHTPNHHVPQPPQAVFPACICAAVLPIVHLMEDGEVREDGVAVSAVAQQVLWNCLIEDPSTVLRHFLEKLTISNRQDELMYMLRKLLLNIGDFPAQTSHILFNYLVGLIMYFVRTPCEWGMDAISATLTFLWEVVGYVEGLFFKDLKQTMKKEQCEVKLLVTASMPGTKTLVVHGQNECDIPTQLPVHEDTQFEALLKECLEFFNIPETQSSHYFLMDKRWNLIHYNKTYVRDIYPFRRSVSPQLNLVQMHPEKGQELIQKQVFTRKLEEVGRVLFLISLTQKIPTAHKQSHVSMLQEDLLRLPSFPRNAIDAEFSLFSDPQAGKELFGLDTLQKSLWIKLLEEMFLGMPSEFPWGDEIMLFLNVFNGALILHPEDSALLRQYAATVINTAVHFNHLFSLSGYQWVLPSMLQVYADYESNPQLRQAMEFACRQFYVLHRKPFILQLFASVAPLLEFPDAANNGTSKGVSAQCLFDLLQSLEGDTPDILDILELVKAEKPLKSLDFCYGNEDLTFSISEAIKLCVTVVAYAPESFRSLQMLMVLEALVPCYLQKLKRQTSQAETVTAAREEIAAMAALATSLQALLYSVEVLTRPMTAPQMSRCDQGHKGTTAANHTMSAGVNTRYPEQGAKLHFIRENLHLLEEGQGLPREELDERIAREEFRRPRESLLNICTEFYKHCGPRLKILQNLAGEPRVTSLELLDVKSHMRLAEIAHSLLKLAPYDTQTMESRGLRRYIMEMLPITDWTAEAVRPALILILKRLDRMFNKIHKMPTLRRQVEWEPASNLIEGVCLTLQRQPIISFLPHLRSLINVCVNLVMGVVGPSSVADGLPLLHLSPYLSPPLPFSTAVVRLVALQIQALKEDFPLSHVVSPFTNQERREGMLLNLLIPFVLTVGSGSKDSPWLEQPEVLLLLQTVINILLPPRIISTSRSKNFMLESSPAHCSTPGDAGKDLRREGLAESTSQAAYLALKVILVCFERQLDSQWYWLSLQVKEMALRKVGGLALWDFLDFIVRTRIPIFVLLRPFIQCKLLAQPADNHEELTARQHIADQLERRFIPRPLCKSSLIAEFNNELKILKEAVHSGSAYQGKTSVSTVGTSTSAYRLSLATMSRSNTGTGTVWEQDSEPSQQASQDTLSRTDEEDEENDSLSMPSVVSEQEAYLMGAIGRRRFSSHLSSMSAPQAEVGMLPSQSEPNVLDDSPSLATEGSLSRVASVQSEPGQQNLLLQQPLGRKRGLRQLRRPLLSRQKTQTEPRSRHGARLSTTRRSIQPKPKPSADQKRSVTFTEAQPEAAPPSPAKSPASAAQLQGCSRSSPQESSKQEAPSKTVLTSSPAVVVADLHSQTTGQSEVLSAEKEKEENVESRPATAQGTPPAQLSDTEDYAGLETTSLLQHGDTVLHISEDNGMENPLLATHFSFTHVELGETDVDLDESHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TSG9</accession>
    <name>A0A8C2TSG9_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">CKLF like MARVEL transmembrane domain containing 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">CMTM4</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015729468.1">
        <property type="nucleotide sequence ID" value="XM_015873982.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TSG9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005025042.1">
        <property type="protein sequence ID" value="ENSCJPP00005018031.1"/>
        <property type="gene ID" value="ENSCJPG00005014644.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107319287"/>
    <dbReference type="KEGG" id="cjo:107319287"/>
    <dbReference type="CTD" id="146223"/>
    <dbReference type="GeneTree" id="ENSGT00940000159573"/>
    <dbReference type="OrthoDB" id="10028364at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050578">
        <property type="entry name" value="MARVEL-CKLF_proteins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22776:SF29">
        <property type="entry name" value="CKLF-LIKE MARVEL TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22776">
        <property type="entry name" value="MARVEL-CONTAINING POTENTIAL LIPID RAFT-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51225">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="8">
        <location>
            <begin position="49"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="186"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005018031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="211" mass="23406" checksum="69440B215A58C676" modified="2022-01-19" version="1">MRNGEDLEGFDGEASSTSMISGASSPYQPTTEPVSQRRGLGGLRCDLDYLRGTFGGIKLAEVVLALIAFICIETIMECSPCEGLYFFEFVSCSALVVTGVLLLMFSLNLHTRIPQINWNLTDLINTGLSTFFFFIASVVLAALNHKTGAEIAAVIFGFLATAVYAVNTYLAIQKWRMNSRQQNSRQTSEYIRARTESREVDHRPEIQRLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TU29</accession>
    <name>A0A8C2TU29_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TU29"/>
    <dbReference type="Ensembl" id="ENSCJPT00005025630.1">
        <property type="protein sequence ID" value="ENSCJPP00005018400.1"/>
        <property type="gene ID" value="ENSCJPG00005014984.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005018400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="166" mass="17909" checksum="149588B659151AB9" modified="2022-01-19" version="1">GGQNSLRRTNLALVVGTFLEDSFWKAITVSAAGDEDEDESGEERLPSCFDIDSVTAVVFVAFGTSVPGGESAGRVWGWSRGDWGPYPSLSGSTTELPIPSMKRPLTPVYVTKKSQPSPKATSPTGLFPLLWSTPPLQGDAVLFLLFRNCRSLIGNLLLFFLLPIAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TUG6</accession>
    <name>A0A8C2TUG6_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Keratin-associated protein 6-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">LOC107324402</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015739868.1">
        <property type="nucleotide sequence ID" value="XM_015884382.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TUG6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005024062.1">
        <property type="protein sequence ID" value="ENSCJPP00005017235.1"/>
        <property type="gene ID" value="ENSCJPG00005014096.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107324402"/>
    <dbReference type="KEGG" id="cjo:107324402"/>
    <dbReference type="GeneTree" id="ENSGT01030000235366"/>
    <dbReference type="OrthoDB" id="9118337at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005017235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="89" mass="10458" checksum="7E30A25740B3857E" modified="2022-01-19" version="1">MTFYYQNQWDDSCYSPCSYGSVYSYRTYDCGSPCGYRSYDCGIPCGYRGSWGLSGYRDCYPSYSSRCYSPCYTRYTRRYSLGSCYPCYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TUH1</accession>
    <name>A0A8C2TUH1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TUH1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005024858.1">
        <property type="protein sequence ID" value="ENSCJPP00005017876.1"/>
        <property type="gene ID" value="ENSCJPG00005014524.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00910000148470"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034258368" description="Secreted protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005017876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="86" mass="9860" checksum="1C8EDFB781BFA2C4" modified="2022-01-19" version="1">CFFCLFLFLSFLHIHTVFHGSNKAAVKKALEFYKFAMVGVKENIVNCTVLLTPKSNFFCLVYLDFSVCFVVKQPTRVVVHKTAFES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TWF2</accession>
    <name>A0A8C2TWF2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Carbonic anhydrase</fullName>
            <ecNumber evidence="3 7">4.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">CA7</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 7">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the alpha-carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="3 7"/>
    <dbReference type="RefSeq" id="XP_015729558.1">
        <property type="nucleotide sequence ID" value="XM_015874072.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TWF2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005025038.1">
        <property type="protein sequence ID" value="ENSCJPP00005018027.1"/>
        <property type="gene ID" value="ENSCJPG00005014640.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107319336"/>
    <dbReference type="KEGG" id="cjo:107319336"/>
    <dbReference type="CTD" id="766"/>
    <dbReference type="GeneTree" id="ENSGT00940000159757"/>
    <dbReference type="OrthoDB" id="429145at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070050">
        <property type="term" value="P:neuron cellular homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032849">
        <property type="term" value="P:positive regulation of cellular pH reduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032230">
        <property type="term" value="P:positive regulation of synaptic transmission, GABAergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001225">
        <property type="term" value="P:regulation of chloride transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd03149">
        <property type="entry name" value="alpha_CA_VII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.200.10:FF:000001">
        <property type="entry name" value="Carbonic anhydrase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="entry name" value="Alpha carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041890">
        <property type="entry name" value="Alpha_CA_VII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023561">
        <property type="entry name" value="Carbonic_anhydrase_a-class"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018338">
        <property type="entry name" value="Carbonic_anhydrase_a-class_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952:SF124">
        <property type="entry name" value="CARBONIC ANHYDRASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01057">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51069">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00162">
        <property type="entry name" value="ALPHA_CA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51144">
        <property type="entry name" value="ALPHA_CA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="8">
        <location>
            <begin position="5"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005018027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="264" mass="29781" checksum="0F18CF8FF4D20875" modified="2022-01-19" version="1">MTGHHSWGYGQDDGPSEWHKSYPIAQGNRQSPIDIISAKAVYDPKLMPLVISYESCTSLNISNNGHSVMVEFEDTDDKTVISGGPFESPFRLKQFHFHWGAKHSEGSEHTIDGKPFPCELHLVHWNAKKYATFGEAAAAPDGLAVVGVFLEIGKEHTSMNRLTDAFYMVKFKGTKAQFRSFNPKCLLPLSLDYWTYLGSLTTPPLNESVIWVVLKEPISISEKQLEKFRMLLFTSEDDQKVQMVNNFRPPQPLKGRTVRASFKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TWR7</accession>
    <name>A0A8C2TWR7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">SLC31A1</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="21">Mobilizes copper(1+) out of the endosomal compartment, making copper(1+) available for export out of the cells.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>Ag(+)(out) = Ag(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:75207"/>
            <dbReference type="ChEBI" id="CHEBI:49468"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>Cu(+)(out) = Cu(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:75211"/>
            <dbReference type="ChEBI" id="CHEBI:49552"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Apical cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Basolateral cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Early endosome membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="22">Membrane</location>
            <topology evidence="22">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Recycling endosome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 22">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TWR7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005027452.1">
        <property type="protein sequence ID" value="ENSCJPP00005019856.1"/>
        <property type="gene ID" value="ENSCJPG00005016060.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155147"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014704">
        <property type="term" value="C:intercalated disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015080">
        <property type="term" value="F:silver ion transmembrane transporter activity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051649">
        <property type="term" value="P:establishment of localization in cell"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:intracellular copper ion homeostasis"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:plasma membrane copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051259">
        <property type="term" value="P:protein complex oligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:vascular endothelial growth factor receptor-2 signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF22">
        <property type="entry name" value="HIGH AFFINITY COPPER UPTAKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14 22" id="KW-0186">Copper</keyword>
    <keyword evidence="12 22" id="KW-0187">Copper transport</keyword>
    <keyword evidence="18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0967">Endosome</keyword>
    <keyword evidence="15 22" id="KW-0406">Ion transport</keyword>
    <keyword evidence="17 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0558">Oxidation</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 22" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004554"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023097"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00036192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00036430"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00037299"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005019856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="193" mass="21381" checksum="05DA7F79CE1A1E18" modified="2022-01-19" version="1">RAFLNASAIKMSHHMMNSSTLPTTHPEHHHSTASPGGGHGSGMMMMAMTFHFSYENVPLLFSGLTINTPGEMAGAFVAVFFLAMFYEGLKIARECLLRKSQVSIRYNSMPVPGPNGTILMETHKTVGQQMLSFPHLLQTILHIIQVVVSYFLMLIFMTYNGYLCIAVAAGAGMGYFFFSWKKAVVVDITEHCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TX94</accession>
    <name>A0A8C2TX94_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TX94"/>
    <dbReference type="Ensembl" id="ENSCJPT00005025543.1">
        <property type="protein sequence ID" value="ENSCJPP00005018327.1"/>
        <property type="gene ID" value="ENSCJPG00005014932.1"/>
    </dbReference>
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        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034407520" evidence="1">
        <location>
            <begin position="24"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005018327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="64" mass="7046" checksum="6A561294EBFE5D67" modified="2022-01-19" version="1">FSPPIRSLPYFLLMKFCAHLTSLYLFSQISLTGVKETSQQMLPVHGCRLPTSGSGCPGPHPSWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TXH8</accession>
    <name>A0A8C2TXH8_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Hemoglobin subunit alpha-D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC107320986</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the globin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015732923.1">
        <property type="nucleotide sequence ID" value="XM_015877437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TXH8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005028068.1">
        <property type="protein sequence ID" value="ENSCJPP00005020343.1"/>
        <property type="gene ID" value="ENSCJPG00005016409.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107320986"/>
    <dbReference type="KEGG" id="cjo:107320986"/>
    <dbReference type="GeneTree" id="ENSGT00940000165231"/>
    <dbReference type="OrthoDB" id="8751793at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072562">
        <property type="term" value="C:blood microparticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031838">
        <property type="term" value="C:haptoglobin-hemoglobin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005833">
        <property type="term" value="C:hemoglobin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031720">
        <property type="term" value="F:haptoglobin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043177">
        <property type="term" value="F:organic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08927">
        <property type="entry name" value="Hb-alpha-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.490.10:FF:000002">
        <property type="entry name" value="Hemoglobin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002338">
        <property type="entry name" value="Hemoglobin_a-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050056">
        <property type="entry name" value="Hemoglobin_oxygen_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002339">
        <property type="entry name" value="Hemoglobin_pi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11442">
        <property type="entry name" value="HEMOGLOBIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11442:SF41">
        <property type="entry name" value="HEMOGLOBIN SUBUNIT ZETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00612">
        <property type="entry name" value="ALPHAHAEM"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00815">
        <property type="entry name" value="PIHAEM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Globin" evidence="8">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005020343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="141" mass="15679" checksum="BC3028DEA3377E4C" modified="2022-01-19" version="1">MLTAEDKKLIQQAWEKASSHQEDFGAEALLRMFTAYPQTKTYFPHFDLSPGSDQIRGHGKKVLAALGNAVKNIDNLSQAMSELSNLHAYNLRVDPVNFKLLSQCIQVVLAAHMGKDYSPEVHAAFDKFLSAVAAVLAEKYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U0R4</accession>
    <name>A0A8C2U0R4_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Trimethyllysine dioxygenase, mitochondrial</fullName>
            <ecNumber evidence="7">1.14.11.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Epsilon-trimethyllysine 2-oxoglutarate dioxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">TML hydroxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">TML-alpha-ketoglutarate dioxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">TMLHE</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="19">Converts trimethyllysine (TML) into hydroxytrimethyllysine (HTML).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>N(6),N(6),N(6)-trimethyl-L-lysine + 2-oxoglutarate + O2 = (3S)-3-hydroxy-N(6),N(6),N(6)-trimethyl-L-lysine + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:14181"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:58100"/>
            <dbReference type="ChEBI" id="CHEBI:141499"/>
            <dbReference type="EC" id="1.14.11.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amine and polyamine biosynthesis; carnitine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the gamma-BBH/TMLD family.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.8" evidence="7"/>
    <dbReference type="RefSeq" id="XP_015716149.1">
        <property type="nucleotide sequence ID" value="XM_015860663.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U0R4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005028999.1">
        <property type="protein sequence ID" value="ENSCJPP00005021079.1"/>
        <property type="gene ID" value="ENSCJPG00005016890.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107312861"/>
    <dbReference type="KEGG" id="cjo:107312861"/>
    <dbReference type="CTD" id="55217"/>
    <dbReference type="GeneTree" id="ENSGT00530000063582"/>
    <dbReference type="OrthoDB" id="408743at2759"/>
    <dbReference type="UniPathway" id="UPA00118"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050353">
        <property type="term" value="F:trimethyllysine dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045329">
        <property type="term" value="P:carnitine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00250">
        <property type="entry name" value="CAS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000001">
        <property type="entry name" value="Trimethyllysine dioxygenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2020.30:FF:000003">
        <property type="entry name" value="trimethyllysine dioxygenase, mitochondrial isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2020.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010376">
        <property type="entry name" value="GBBH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038492">
        <property type="entry name" value="GBBH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012776">
        <property type="entry name" value="Trimethyllysine_dOase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02410">
        <property type="entry name" value="carnitine_TMLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF51">
        <property type="entry name" value="TRIMETHYLLYSINE DIOXYGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06155">
        <property type="entry name" value="GBBH-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0124">Carnitine biosynthesis</keyword>
    <keyword evidence="12" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Gamma-butyrobetaine hydroxylase-like N-terminal" evidence="23">
        <location>
            <begin position="120"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="TauD/TfdA-like" evidence="22">
        <location>
            <begin position="224"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="25"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00016835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00032283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00046008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF06155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005021079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="484" mass="56039" checksum="086D4C9F6EA86B73" modified="2022-01-19" version="1">MVCGALHLGLPPLYRLCSARSGARAGYGPQPHRHSPQPPPLPQLHPARRNSAWGRPERGRDLLQIRMWCRRLACLLSVPCQHTRHHLLGLSRGRRTFTTAVARWHHTAPESISCAWQLHGDHLELRYADTLMRFDFVWLRDHCRSASCYNAKTNQRSLDTASVDLGIKPKAVRVDETTLFLTWPDGHVTRYGLQWLVKNSYEGQKQQVMHPRILWNAEIYRQAQVPSVDCRSFLETDEGLKEFLQNFLLYGIAFVENVTPTKEDTQILAERISLIRETIYGRMWYFTSDFSRGDTAYTKLALDRHTDTTYFQEPCGIQVFHCLKHEGTGGRTLLVDGFYAAEQVLRQAPDQFELLSKVPLKHEYIENVGDCHNHMIGVGPVLNVYPWNNELYLIRYNNYDRAVINTVPYDVVNRWYTAHRTLTTELRRPENELWVKLKPGKALFIDNWRVLHGREAFTGYRQLCGCYLTRDDVLNTARLLGLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U1J1</accession>
    <name>A0A8C2U1J1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Diphthine--ammonia ligase</fullName>
            <ecNumber evidence="3">6.3.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP-binding domain-containing protein 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Diphthamide synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Diphthamide synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Protein DPH6 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">DPH6</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>diphthine-[translation elongation factor 2] + NH4(+) + ATP = diphthamide-[translation elongation factor 2] + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19753"/>
            <dbReference type="Rhea" id="RHEA-COMP:10172"/>
            <dbReference type="Rhea" id="RHEA-COMP:10174"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16692"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82696"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.14"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Diphthine--ammonia ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.14" evidence="3"/>
    <dbReference type="RefSeq" id="XP_015720379.1">
        <property type="nucleotide sequence ID" value="XM_015864893.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U1J1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005030092.1">
        <property type="protein sequence ID" value="ENSCJPP00005021964.1"/>
        <property type="gene ID" value="ENSCJPG00005017531.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107314989"/>
    <dbReference type="KEGG" id="cjo:107314989"/>
    <dbReference type="CTD" id="89978"/>
    <dbReference type="GeneTree" id="ENSGT00420000029820"/>
    <dbReference type="OrthoDB" id="686384at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017178">
        <property type="term" value="F:diphthine-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01994">
        <property type="entry name" value="AANH_PF0828-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06155">
        <property type="entry name" value="eu_AANH_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06156">
        <property type="entry name" value="eu_AANH_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.40:FF:000010">
        <property type="entry name" value="Diphthine--ammonia ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000069">
        <property type="entry name" value="diphthine--ammonia ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1490.10:FF:000001">
        <property type="entry name" value="Diphthine--ammonia ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.40:FF:000012">
        <property type="entry name" value="diphthine--ammonia ligase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1490.10">
        <property type="entry name" value="putative n-type atp pyrophosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002761">
        <property type="entry name" value="Diphthami_syn_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030662">
        <property type="entry name" value="DPH6/MJ0570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00290">
        <property type="entry name" value="MJ0570_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12196:SF2">
        <property type="entry name" value="DIPHTHINE--AMMONIA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12196">
        <property type="entry name" value="DOMAIN OF UNKNOWN FUNCTION 71 DUF71 -CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01902">
        <property type="entry name" value="Diphthami_syn_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Diphthamide synthase" evidence="13">
        <location>
            <begin position="15"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005021964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="729" mass="80601" checksum="92C62939A82F6F0C" modified="2022-01-19" version="1">MTPVQCYRPGAACGMRVVALISGGKDSCYNMMQCVAAGHQIVALANLRPAESTGQTDELDSYMYQTVGHHAIDLYADAMDLPLYRCFIKGTSINTGKVYTTCQEDEVEDLYHLLKLVKDREAVEGVSVGAILSDYQRVRVEDVCRRLNLQPLAYLWRRKEEILLKEMISSNIEAIIIKVAAFGLDPDKHLGKTLDQMEPYLLETSHRSELSLPKGENKVSEKYGVHICGEGGEYETFTLDCPLFKKKIVVDSAKVVMHSADAFAPVAYLHFLKMHLENKEKSSDTFMVSSCSCEESCSNGDILPSSELDEPQDFGPVIWKDLKHTSLDFSKTVGISGKSVTGYQWFSCITAHFHPSKDKNAQEAAREAFSSLKATITSEGLKLKDIILVHLYMKSMKDFNVINSVYVTEFDLCPPARVCVETLLPDDVLFCIDCLAHSCDIATDDVLSEEKLVMHVQSISHWAPASIGPYSQSIKVGDILYCAGQIGLVPCTMQLVSGGVWSEATVALSHVEKVLQAMSQKTMLCHVITAICYVTDSKHIPVAHSIWRKKVRGCKKVEDLEAYNEVAAECGTLAVVVVTNLPRDAAIEWHVTAVIDDPLHRKHFAKKMLSESYQIDCESVKSSSASCASVSVRLSLILPPASQLDLNRPLHDLVSVFGQAVENLSEDFNASPLSFRAFFKKDVFDIGVLQSGLQENLEKCLGKKTPALILVPVVDLPGKEVIHTICWLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U216</accession>
    <name>A0A8C2U216_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Exocyst complex component 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC107312865</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2U216"/>
    <dbReference type="Ensembl" id="ENSCJPT00005029063.1">
        <property type="protein sequence ID" value="ENSCJPP00005021131.1"/>
        <property type="gene ID" value="ENSCJPG00005016922.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000166719"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028258">
        <property type="entry name" value="Sec3-PIP2_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048628">
        <property type="entry name" value="Sec3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019160">
        <property type="entry name" value="Sec3_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16092:SF20">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT SEC3 PIP2-BINDING N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16092">
        <property type="entry name" value="SEC3/SYNTAXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15277">
        <property type="entry name" value="Sec3-PIP2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20654">
        <property type="entry name" value="Sec3_C-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09763">
        <property type="entry name" value="Sec3_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01313">
        <property type="entry name" value="Sec3-PIP2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component Sec3 PIP2-binding N-terminal" evidence="7">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="406"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="188"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005021131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="714" mass="81103" checksum="6BA6A50EB17F851A" modified="2022-01-19" version="1">MSILCVLVDALRPMQPFLVKVKVDRGEQYKIAYKWPLAELKLVDGKTLDEVNMDFDLQFDKIYKWTASSFDEKKTFIRCLWKLNHRFLSSAVTFVNVHSCSVEGRQSLQEDRRDTVETENQEELSVYQEMTPKEAADVLKLMEEHEPLVNNSIAFAEQLSRDLHVLDEANLQAIISSEKQVTQLMSFIDEALAEVARVEETLQVYDELLGSLKQQMDHIYQENSLLHHITSNKAKLMDEILFLTTHLDLGNEHCEALSCADLSSPSGVEACIAAAEALSACMNIQIHPGYRKLQAVAEQLIMFETLKQNFENRFIGHITNIFERQGSAQIPALTQPMDKLSAPSHGLQHKELVPYTPLMAWLRNANPVLFCDLPKVYAQNLSRLYDREIKAFFEQAKTLLVARRKGSLQEGQEKPAGMGSRQHPRWSLPGSREGQEDALNKGNVIKILEQVLRELRPLCIAEQLFIEKFFQLSQNSTELQVLEEEGSTASPVDPACVKPPSQPEEQTAQLLSEIFSSLDPELRCFLDVCNKAHPFSCLQILVTLNDCIFEMWGKTSAIPSSFFNTVLGNMLLLAKSSFNKFIGTLCKEIEEAKLPSKLKVGILPSVSRFEEFVNFSEAVFRTAQRRAELDKAHLRLADSIFNSINSLSSANLKVNTDMVMMENFYHVHCFLCQKKIQCLDGKKREAKQRYSEHMEKYVIGSLGQPLEKLNVSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U3L4</accession>
    <name>A0A8C2U3L4_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Zinc finger protein 384</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Nuclear matrix transcription factor 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">ZNF384</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Transcription factor that binds the consensus DNA sequence [GC]AAAAA. Seems to bind and regulate the promoters of MMP1, MMP3, MMP7 and COL1A1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Interacts with BCAR1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2U3L4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005028709.1">
        <property type="protein sequence ID" value="ENSCJPP00005020850.1"/>
        <property type="gene ID" value="ENSCJPG00005016731.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156904"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000158">
        <property type="entry name" value="Zinc finger protein 362"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000549">
        <property type="entry name" value="zinc finger protein 384 isoform X1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000544">
        <property type="entry name" value="zinc finger protein 384 isoform X3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000216">
        <property type="entry name" value="Zinc finger protein 384 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000369">
        <property type="entry name" value="Zinc finger protein 384 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="260"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="288"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="316"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="349"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="377"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="405"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="435"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="465"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="201"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="500"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="208"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="500"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="513"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00058819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00065182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00068010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00083938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005020850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="567" mass="62435" checksum="831108B6061AAC9D" modified="2022-01-19" version="1">MARPREAASHGRPASWGPPSSTVTLAVCLQRRPWKEERCKRRESERARMEESHFNSSPYFWPAVPTVSGQIDNTMFINKMKEQLLPTEKGCSLAPPHYPALLTVPTSVALPTGIAMDSDTKPEQLTPHSQAPVTQNITVVPVQSAGLMTAGPGLVITSPSGSLVTTASSAQTFPISAPMIVSALPPGSQAALQVVPDLTKKGTTTLSEGGGGGGGGGVAPKPPRGRKKKRLQESGLPEMSDPFVLSNEDDEDQHKDGKTYRCRMCSLTFYSKSEMQIHSKSHTETKPHKCPHCSKSFANSSYLAQHIRIHSGAKPYTCSYCQKAFRQLSHLQQHTRIHSKLHTAIVKPHKCPHCSKSFANTSYLAQHLRIHSGAKPYTCRYCQKAFRQLSHLQQHTRIHTGDRPYKCAHPGCEKAFTQLSNLQSHRRQHNKDKPFKCHNCHRAYTDAASLEVHLATHTVKHAKVYTCSICSRAYTSETYLMKHMRKHNIPDPQQQVVQAQAQASQQQQHFQPQGGGAAGGPSGDTNQPNPPPQCSFDLTPYKTSEHHKDICLTVSTSAIQVEHLSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U7X2</accession>
    <name>A0A8C2U7X2_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Smoothelin like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">SMTNL2</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the smoothelin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015736608.1">
        <property type="nucleotide sequence ID" value="XM_015881122.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U7X2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005033865.1">
        <property type="protein sequence ID" value="ENSCJPP00005024875.1"/>
        <property type="gene ID" value="ENSCJPG00005019569.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107322754"/>
    <dbReference type="KEGG" id="cjo:107322754"/>
    <dbReference type="CTD" id="342527"/>
    <dbReference type="GeneTree" id="ENSGT00940000154495"/>
    <dbReference type="OrthoDB" id="21607at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="CDD" id="cd21261">
        <property type="entry name" value="CH_SMTNL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000009">
        <property type="entry name" value="smoothelin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050540">
        <property type="entry name" value="F-actin_Monoox_Mical"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23167">
        <property type="entry name" value="CALPONIN HOMOLOGY DOMAIN-CONTAINING PROTEIN DDB_G0272472-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23167:SF37">
        <property type="entry name" value="SMOOTHELIN-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="354"/>
            <end position="461"/>
        </location>
    </feature>
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        <location>
            <begin position="104"/>
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            <begin position="238"/>
            <end position="279"/>
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    </feature>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00061655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005024875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="464" mass="51235" checksum="015B18E3413BACA5" modified="2022-01-19" version="1">MSSEIDNLNSREAKTVCEALGRYEDTLRGAVREIHVDIQVFKQGVSRQVDEVLRLASPLARTVSELQQENQRLRVQLERLARQVEALGRSAGLPQELRDEAERSPPAVEPSSPAPAFSGDRFSTLAKLAVSGRSQSVDLDDHHKPEVRRVFSSSIIENGHQSSSGQAKVSHELTSFYTSDSSPEAHAPAMTLQMPHLPVTAVTKISEKFSGEAIHSAGTTNASTGLLGQNQSKNEMALKTSNQSVRTMTSSASGVNATSVSSASCEAISGNKTGESATDSYCGVTPKPHSSPPTVHRQVERRRELVRSQTLPRTTGPQARKALFEKFEQDSGKGRGQSRAKLKRSQSFGVASASSIKQILLDWCRSKTIGYKHIDLQNFSSSWNDGMAFCALVHSFFPESFDYNKLDPTNRKQNFELAFTMAEKMAHCDRLIEVDDMMMMGHKPDPMCVFTYVQSLYNHLRHFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U8M4</accession>
    <name>A0A8C2U8M4_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">G-protein coupled receptor 143</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">GPR143</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Receptor for tyrosine, L-DOPA and dopamine. After binding to L-DOPA, stimulates Ca(2+) influx into the cytoplasm, increases secretion of the neurotrophic factor SERPINF1 and relocalizes beta arrestin at the plasma membrane; this ligand-dependent signaling occurs through a G(q)-mediated pathway in melanocytic cells. Its activity is mediated by G proteins which activate the phosphoinositide signaling pathway. Also plays a role as an intracellular G protein-coupled receptor involved in melanosome biogenesis, organization and transport.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Interacts with heterotrimeric G(i) proteins. Interacts with ARRB1 and ARRB2. Interacts with MLANA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Apical cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Melanosome membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the G-protein coupled receptor OA family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015742336.1">
        <property type="nucleotide sequence ID" value="XM_015886850.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U8M4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005031429.1">
        <property type="protein sequence ID" value="ENSCJPP00005022938.1"/>
        <property type="gene ID" value="ENSCJPG00005018220.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107325713"/>
    <dbReference type="KEGG" id="cjo:107325713"/>
    <dbReference type="CTD" id="4935"/>
    <dbReference type="GeneTree" id="ENSGT00390000016722"/>
    <dbReference type="OrthoDB" id="10069455at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030054">
        <property type="term" value="C:cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033162">
        <property type="term" value="C:melanosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035240">
        <property type="term" value="F:dopamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072544">
        <property type="term" value="F:L-DOPA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035643">
        <property type="term" value="F:L-DOPA receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072545">
        <property type="term" value="F:L-tyrosine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032438">
        <property type="term" value="P:melanosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032402">
        <property type="term" value="P:melanosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007200">
        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050848">
        <property type="term" value="P:regulation of calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000144">
        <property type="entry name" value="G protein-coupled receptor 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001414">
        <property type="entry name" value="GPR143"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15177">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15177:SF2">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02101">
        <property type="entry name" value="Ocular_alb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00965">
        <property type="entry name" value="OCULARALBNSM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0458">Lysosome</keyword>
    <keyword evidence="7 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="153"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="287"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="346"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="351"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00054755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00060435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00061093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00063198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00070822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005022938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="392" mass="43766" checksum="BCE8DEDB8F434228" modified="2022-01-19" version="1">MASPRLETYCCPNRDAATQLVMNFQPQVFCGVCIGSASASLLLTILQLLPKKGQSLRKMPKASSSSTILLLISVCDILGGSGVIFRSSVWLGFPSFVANISVANGTDVWPSAFCVGSAMWIQLLYSAGFWWLFCYAVDSYLVVRRSAGLSTIVLYHMMAWGLAVLLCVEGVALLYYPSLSSCERGLEHAIPHYITTYAPLLLVLVVNPVLFRRTVTAVASLLKGRQGIYTENERRLGTEIQMRFFKIMLVFIVCWSSNIINESLLFYLEMQPDINETPLKNIRSAALITWIIMGVLNPMQGFLFTLAFYGWTGWRVDLKWQKREIPWESMSSSTVGDNDYPSPVNYQSNVHDSKKTSTTDSHQTDEAISMLSEGNTSGDDRLTRSSPIYQGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U8T4</accession>
    <name>A0A8C2U8T4_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Acid sensing ion channel subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ASIC2</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>Na(+)(in) = Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:34963"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015741035.1">
        <property type="nucleotide sequence ID" value="XM_015885549.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U8T4"/>
    <dbReference type="SMR" id="A0A8C2U8T4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005033070.1">
        <property type="protein sequence ID" value="ENSCJPP00005024237.1"/>
        <property type="gene ID" value="ENSCJPG00005019136.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107325055"/>
    <dbReference type="KEGG" id="cjo:107325055"/>
    <dbReference type="CTD" id="40"/>
    <dbReference type="GeneTree" id="ENSGT00940000154991"/>
    <dbReference type="OrthoDB" id="5874059at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.820:FF:000001">
        <property type="entry name" value="acid-sensing ion channel 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3590.10:FF:000002">
        <property type="entry name" value="acid-sensing ion channel 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.770:FF:000001">
        <property type="entry name" value="Acid-sensing ion channel subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3590.10">
        <property type="entry name" value="acid-sensing ion channel 1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.820">
        <property type="entry name" value="Acid-sensing ion channel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004724">
        <property type="entry name" value="ENaC_chordates"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020903">
        <property type="entry name" value="ENaC_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00859">
        <property type="entry name" value="ENaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF128">
        <property type="entry name" value="ACID-SENSING ION CHANNEL 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01206">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="3" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00036239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005024237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="507" mass="57585" checksum="3505D0A1200BE402" modified="2022-01-19" version="1">MARGRRVPALRTRLHGLRHMCSRRAALPRRALWVLAFCTALGLLLSWSSNRLLHWLSFPSHTQVRTEWSRQLAFPAVTLCNNNPLRFPRLSKGDLYYAGHWLGLLLPNRTARPLLTELLRGDEARLRWFAKLADFRLFLPPRHYEGISADFMDRLGHQLEDMLLSCKYRGELCGPHNFSAVFTKYGKCYMFNSGEEGRPLLTTVKGGTGNGLEIMLDIQQDEYLPIWGETEETTFEAGVKVQIHSQSEPPFVQELGFGVAPGFQTFVATQEQRLTYLPPPWGECRSSDMGLDFFPVYSITACRIDCETRYIVENCNCKMVHMPGDAPFCTPEQYKECAEPALGLLAEKDSNYCICRTPCNLTRYNKELSMVKIPSKTSAKYLEKKFNKSEKYISENILVLDIFFEALNYETIEQKKAYEVAALLGDIGGQMGLFIGASILTILELFDYIYELIKEKLLDLLGKEEEEGSHDENVSTCDPMPNHSETISHTVNVPLQATLGTLEEIAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U9B9</accession>
    <name>A0A8C2U9B9_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">RNA binding protein with serine rich domain 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">RNPS1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the splicing factor SR family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2U9B9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005031855.1">
        <property type="protein sequence ID" value="ENSCJPP00005023216.1"/>
        <property type="gene ID" value="ENSCJPG00005018448.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00730000111029"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061574">
        <property type="term" value="C:ASAP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048025">
        <property type="term" value="P:negative regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd12365">
        <property type="entry name" value="RRM_RNPS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000210">
        <property type="entry name" value="RNA-binding protein with serine-rich domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034201">
        <property type="entry name" value="RNPS1_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15481">
        <property type="entry name" value="RIBONUCLEIC ACID BINDING PROTEIN S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15481:SF2">
        <property type="entry name" value="RNA-BINDING PROTEIN WITH SERINE-RICH DOMAIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="158"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="30"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="65"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="124"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="148"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005023216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="231" mass="25288" checksum="43AF1230BBB2D810" modified="2022-01-19" version="1">MGIKKKSLLGLKENNKKSSTRAPSPTKRKDRSEEKSKDRSKDKAATKESGEKDRGRDKTRKRRSASSGSSSTRSRSSSTSSSGSSSSTGSSSGSSSSSASSRSGSSSTSRSSSSSSSSGSPSPSRRRHDNRRRSRSKSKPPKRDEKERKRRSPSPRPTKVHVGRLTRNVTKDHIMEIFSTYGKIKMIDMPVDRLNPHLSKGYAYVEFENPDDAEKALKHMDGGRCQMLQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UBI6</accession>
    <name>A0A8C2UBI6_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fibrinogen-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC107308192</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015707371.1">
        <property type="nucleotide sequence ID" value="XM_015851885.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UBI6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005034412.1">
        <property type="protein sequence ID" value="ENSCJPP00005025285.1"/>
        <property type="gene ID" value="ENSCJPG00005019863.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107308192"/>
    <dbReference type="KEGG" id="cjo:107308192"/>
    <dbReference type="GeneTree" id="ENSGT00940000164070"/>
    <dbReference type="OrthoDB" id="7725475at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005577">
        <property type="term" value="C:fibrinogen complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005201">
        <property type="term" value="F:extracellular matrix structural constituent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072377">
        <property type="term" value="P:blood coagulation, common pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042730">
        <property type="term" value="P:fibrinolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070527">
        <property type="term" value="P:platelet aggregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034116">
        <property type="term" value="P:positive regulation of heterotypic cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.215.10:FF:000001">
        <property type="entry name" value="Tenascin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.530.10">
        <property type="entry name" value="Gamma-fibrinogen Carboxyl Terminal Fragment, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037579">
        <property type="entry name" value="FIB_ANG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47221">
        <property type="entry name" value="FIBRINOGEN ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47221:SF5">
        <property type="entry name" value="FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034734162" evidence="5">
        <location>
            <begin position="20"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="6">
        <location>
            <begin position="87"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005025285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="336" mass="38953" checksum="DFC9A6ADEC120A90" modified="2022-01-19" version="1">MSVLMAWLLLLLLVNFSSPAPRFSEKDICLLDNNKLRQRLKHLQDLLYLYELQLKDILENTYHRTKSGIFSGNRSMQHEPLLPTTSGNLIVYDQDCSAVYNRKNTKSGYYRVRPRADQEPFLVYCDMSDGGGWTVIQRRSNGRENFNRKWNDYKLGFGKFQDKNDEYWLGNDHIHDLLARGESSLKIDLMDWHGERRYAIYENFQLTNEEDNYRLWFGTYSGNAGDALSGGSSFEDQWSASHRGMQFTTSDKDHDRFLAGNCALESSGGWWFNRCHAVNLNGWYYKTGRYNGSHDNGIVWSTWRGMWYSLKSSAMKIRSPFFVDSESGDGEDGQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UBX0</accession>
    <name>A0A8C2UBX0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Syntaxin-8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">STX8</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Vesicle trafficking protein that functions in the early secretory pathway, possibly by mediating retrograde transport from cis-Golgi membranes to the ER.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015735413.1">
        <property type="nucleotide sequence ID" value="XM_015879927.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UBX0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005035801.1">
        <property type="protein sequence ID" value="ENSCJPP00005026450.1"/>
        <property type="gene ID" value="ENSCJPG00005020561.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107322179"/>
    <dbReference type="KEGG" id="cjo:107322179"/>
    <dbReference type="CTD" id="9482"/>
    <dbReference type="GeneTree" id="ENSGT00390000007779"/>
    <dbReference type="OrthoDB" id="428895at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15852">
        <property type="entry name" value="SNARE_Syntaxin8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000036">
        <property type="entry name" value="Putative Syntaxin-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041875">
        <property type="entry name" value="Syntaxin-8_SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF124">
        <property type="entry name" value="SYNTAXIN-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="13">
        <location>
            <begin position="145"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00072662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005026450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="484" mass="53409" checksum="0E4C576280679667" modified="2022-01-19" version="1">MAPDPWLSQYDAACQLAQEVAERIQERSRHRRNGESSAKLNVIIRSSLQNLKEKIDQLKDSLLRAVSTHQITRLEGDRRQNLVDDLLTRQKQLQASYKNEGTEPDVIRSSLMAGGVKRGVTNPWLLEESEETRGLGFDEIRQQQRRIIEEQDAGLDALSSIISRQKQMGQEIGNELDEQNEIIDDLTNLVENTDSRLRTQTRHVKMVDRKSTSCDPMKHMGVGAFNNPSRSLVLICVRVANDFHVRAERNAGGDRAAADCHRRGRCLAHQVGGARWELQLSSAESPVLHKAPCASSEPHSVSMKPCPSDVPPLGARLSTLSLPGFHTVGGHSHAMGDVFPVCPLLLGPWVHSVHGCAQSTPTAALLCPGTCAGVCAPISGPRSASFFYTFKLKGRMTYYKSDPGHSHVAKQGENKTLLFCYLCQFDFRLGRASNNYRIKAGPFLYHLSACCQCSHSPHGTQHLGADFGEGVLLPPRGIPQLCDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UD80</accession>
    <name>A0A8C2UD80_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Glycerol-3-phosphate dehydrogenase [NAD(+)]</fullName>
            <ecNumber evidence="13">1.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">GPD1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Has glycerol-3-phosphate dehydrogenase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>sn-glycerol 3-phosphate + NAD(+) = dihydroxyacetone phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.8"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:11093"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.8" evidence="13"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2UD80"/>
    <dbReference type="Ensembl" id="ENSCJPT00005034335.1">
        <property type="protein sequence ID" value="ENSCJPP00005025222.1"/>
        <property type="gene ID" value="ENSCJPG00005019785.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000003114"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome LGE22C19W28_E50C23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141152">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071320">
        <property type="term" value="P:cellular response to cAMP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071356">
        <property type="term" value="P:cellular response to tumor necrosis factor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046168">
        <property type="term" value="P:glycerol-3-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006127">
        <property type="term" value="P:glycerol-3-phosphate shuttle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045821">
        <property type="term" value="P:positive regulation of glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000088">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000084">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006168">
        <property type="entry name" value="G3P_DH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006109">
        <property type="entry name" value="G3P_DH_NAD-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017751">
        <property type="entry name" value="G3P_DH_NAD-dep_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011128">
        <property type="entry name" value="G3P_DH_NAD-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03376">
        <property type="entry name" value="glycerol3P_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728:SF32">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE [NAD(+)], CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07479">
        <property type="entry name" value="NAD_Gly3P_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01210">
        <property type="entry name" value="NAD_Gly3P_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000114">
        <property type="entry name" value="Glycerol-3-P_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00077">
        <property type="entry name" value="GPDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00957">
        <property type="entry name" value="NAD_G3PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11 12" id="KW-0520">NAD</keyword>
    <keyword evidence="5 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal" evidence="14">
        <location>
            <begin position="8"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal" evidence="15">
        <location>
            <begin position="198"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="13"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="272"/>
            <end position="273"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005025222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="352" mass="37894" checksum="170FE2100441DC8E" modified="2022-01-19" version="1">TAASPGTKVCIVGSGNWGSAIAKIVGSNAARLGTFEKTVSMWVLEEEVGGRKLTEIINTEHENVKYLPGHKLPPNVVAEPDLVKACSGADILLFVVPHQFIGKVCDQIKAHVKKGAIGMSLIKGVDEGPDGLRLISDIIHEKLGIEMSVLMGANIANEVAEEKFCETTIGCKNAQYGQILKELMQTPNFRVTVVQEADTVEICGALKNVVAVGAGFCDGLGFGDNTKAAVIRLGLMEMISFAKVFCKGPVTPTTFLESCGVADLITTCYGGRNRKVAEAFAKTGKSIEQLEKEMLNGQKLQGPQTSAELNRILKTKNMVDKFPLFTAVYQICYEGKPVSDVIKCLQNHPEHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UDQ8</accession>
    <name>A0A8C2UDQ8_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UDQ8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005033857.1">
        <property type="protein sequence ID" value="ENSCJPP00005024869.1"/>
        <property type="gene ID" value="ENSCJPG00005019562.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286902"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33332">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="28"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005024869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="358" mass="40271" checksum="2620A9BECA40CDAE" modified="2022-01-19" version="1">MGPDEIHPRVLKELVEVITEPFSIIFQCSLLMGKVPEDWRLANVTPIYKNGCKEDLGNYRPVSLTSVLGKVMERIILREIMRQVWDNQEFRPSQHAFVKGRSCLTNLISFYDPVTCLKDEGKAVDVVYLDFSKAFDTVSHAILLQKLAACGLDGYSLGWVRSWLEGGAQRVVVNGVKSSWRPVMSGVPQGSVLGPVLFNIFIDGLDEGIECALSKFVDDTKWAGSVNLPEGSEALQRDLDRLESWAKANGMRFNKTKCQVLHFVHNNPRQRYRLGAEWLEDCVEEMDLRVLTDARLNVSQQCAWVAKKANSILACIKNSVTSRNREVVVPLYSALVRHWCGCTSKLCSVLGPSLQERH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UDX2</accession>
    <name>A0A8C2UDX2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="26">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="26">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="30" type="primary">ATP10A</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="30" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="30" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="30" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="21">Catalytic component of P4-ATPase flippase complex, which catalyzes the hydrolysis of ATP coupled to the transport of phosphatidylcholine (PC) from the outer to the inner leaflet of the plasma membrane. Initiates inward plasma membrane bending and recruitment of Bin/amphiphysin/Rvs (BAR) domain-containing proteins involved in membrane tubulation and cell trafficking. Facilitates ITGB1/beta1 integrin endocytosis, delaying cell adhesion and cell spreading on extracellular matrix. Has low flippase activity toward glucosylceramide (GlcCer).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18 26">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphocholine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38583"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:38584"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>a beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine(out) + ATP + H2O = a beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66036"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:22801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:66037"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 25">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="22">Component of a P4-ATPase flippase complex which consists of a catalytic alpha subunit ATP10A and an accessory beta subunit TMEM30A.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="26">Membrane</location>
            <topology evidence="26">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 26">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="26"/>
    <dbReference type="RefSeq" id="XP_015706515.1">
        <property type="nucleotide sequence ID" value="XM_015851029.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005034104.1">
        <property type="protein sequence ID" value="ENSCJPP00005025040.1"/>
        <property type="gene ID" value="ENSCJPG00005019695.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107307517"/>
    <dbReference type="KEGG" id="cjo:107307517"/>
    <dbReference type="CTD" id="57194"/>
    <dbReference type="GeneTree" id="ENSGT00940000157895"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990531">
        <property type="term" value="C:phospholipid-translocating ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140351">
        <property type="term" value="F:glycosylceramide flippase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140345">
        <property type="term" value="F:phosphatidylcholine flippase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903527">
        <property type="term" value="P:positive regulation of membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd02073">
        <property type="entry name" value="P-type_ATPase_APLT_Dnf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000022">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000009">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000109">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000110">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF81">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE VA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 24 26" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="16" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="13 25 26" id="KW-0460">Magnesium</keyword>
    <keyword evidence="17 26" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 25" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 24 26" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14 26" id="KW-1278">Translocase</keyword>
    <keyword evidence="8 26" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 26" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="1084"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="1116"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="1166"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="1195"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="1223"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="1268"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="28">
        <location>
            <begin position="55"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="29">
        <location>
            <begin position="1052"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="460"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="494"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="1400"/>
            <end position="1422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="1499"/>
            <end position="1518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="27">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="27">
        <location>
            <begin position="1403"/>
            <end position="1414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="27">
        <location>
            <begin position="1499"/>
            <end position="1512"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="23">
        <location>
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        </location>
    </feature>
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            <position position="426"/>
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        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="426"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
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        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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        <location>
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        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="428"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
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        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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            <name>ATP</name>
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            <name>ATP</name>
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            <name>ATP</name>
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            <name>ATP</name>
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        <ligand>
            <name>ATP</name>
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        <location>
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        <ligand>
            <name>Mg(2+)</name>
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        <ligand>
            <name>ATP</name>
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        <ligand>
            <name>ATP</name>
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        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00050913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00052223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00056521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00065679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005025040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1518" mass="171385" checksum="394BF2366B1DE0AB" modified="2022-01-19" version="1">MSRGAEGGEGEPQVRPEGKERQRKRRRRKKKESKTRLVRSSLLPPEAEAEKSKRPVLASNRLKTTKYTALSFLPKNLFEQFHRLANVYFVFIALLNFVPAVNAFQPELALAPVLFILAVTAIKDLWEDYSRYRSDQEINHMECLVYCRNEKKYISRYWKEVKIGDFVQLRCNEIIPADILLLSSSDPDGLCHIETANLDGETNLKQRQVVRRFLELDSEFDPLKFTSVIECENPNNDLSRFRGSIVHKSGKKDGLFKENLLLRGCTIRNTEEVVGIVIYAGHETKALLNNNGPRYKRSKLERQMNADVLWCILILLIMCLFSAIGHGLWVWQYGEKKKPVFDVPGPDGKYLSPVLASVYLFLTAIIVFQVMIPISLYVSIEIVKICQVYFIHQDKDLYDEETDSQLQCRALNITEDLGQVQFIFSDKTGTLTENKMVFRRCTVSGIEYSHDDNAKRLAMYQEPDSEEEEAAPKGGTLSQRDSICSHQSIKVIHRSQSTKTHRRTGSRAEAKRASILSKHTAFSSPMEKDITPDPNLLEKVNECAKHLEIMRGHEQPLSHLSPELCDIFDFFIALTICNTVVVTAPNQPRQKVRDRFELKSPVKTIEDFIRRLTPSRLTSGSNSSSSSSLATNKSMHRFGLSILSSTSTESTLLKLEEKLAYSAQMNNNGYSSQQGRMAVGSGPEEGELRYEAESPDEAALVYAARAYNCSLVGRLSDQVSVELPHLGTLNFEVLHTLGFDSIRKRMSVVVRHPLTDEINVYTKGADSVIMDLLLPCSSGDPRGKHQKKIQTKTQNYLNLYAVDGLRTLCIAKRVLSKEEYACWLKSHLEAESSIENREELLFQSALQIEKNLHLLGATGIEDRLQEGVPETIASLRKAGLQIWVLTGDKQETAVNIAYACKLLDHDEEIITLNAESPETCAVLLEQCLQCVESKFSNNTIDEATGNMTVGFTPLYPPSSPVLSSLGLVIDGRTLAYALEPTLEDKFLALAKRCRSVLCCRSTPLQKSMVVKLVRDKLKAMTLAIGDGANDVSMIQVADVGVGISGQEGMQAVMASDFAIPRFRHLEKLLLVHGHWCYSRLANMVLYFFYKNAMFVALLFWYQFYCGFSGSSMVDQWYLIFFNLLFSSLPQLITGVLDKDVPAEVLLSVPQLYKSGQNMEEYQPHMFWMNMIDAMYQSLVCFFIPYFTYYDSEVDIFSWGTPITTTALFTIILHLAIETKTWTFLHWSSCIFSILLFFFVALVYNASCPVCHPPSNPYWTMERLMGDPMFYFTCIISPVAALLPRFLYRTLQGTLFPTQLQLGRQLSKLSPEIRTQLLTKLNVKKGPIHQKQSFANSFSPNLVSNASDSFKPYNQNTPLPASPTDESFFQERTKAECATDQVVSASPQRALYYEESSLPSSAHSQERSVGFHEVNHSSSETELSPMGATFPWSSAVDQTDFSLLKWITSTPLFSRFGTVLQVSSSSLQNETQDGMCVLGSSLQEGFKDFKEQSSNIFQDKMKGTPADHWKSDNSESTFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UEI1</accession>
    <name>A0A8C2UEI1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA-queuosine alpha-mannosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.110</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Glycosyltransferase-like domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">GTDC1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Glycosyltransferase that specifically catalyzes mannosylation of cytoplasmic tRNA(Asp) modified with queuosine at position 34 (queuosine(34)). Mannosylates the cyclopentene moiety of queuosine(34) in tRNA(Asp) to form mannosyl-queuosine(34). Mannosylation of queuosine(34) in tRNA(Asp) is required to slow-down elongation at cognate codons, GAC and GAU, thereby regulating protein translation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>queuosine(34) in tRNA(Asp) + GDP-alpha-D-mannose = O-4''-alpha-D-mannosylqueuosine(34) in tRNA(Asp) + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12885"/>
            <dbReference type="Rhea" id="RHEA-COMP:18572"/>
            <dbReference type="Rhea" id="RHEA-COMP:18581"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:194431"/>
            <dbReference type="ChEBI" id="CHEBI:194442"/>
            <dbReference type="EC" id="2.4.1.110"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:12886"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.110" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2UEI1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005036224.1">
        <property type="protein sequence ID" value="ENSCJPP00005026728.1"/>
        <property type="gene ID" value="ENSCJPG00005020785.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005036226.1">
        <property type="protein sequence ID" value="ENSCJPP00005026730.1"/>
        <property type="gene ID" value="ENSCJPG00005020785.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000006631"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016438">
        <property type="term" value="F:tRNA-queuosine(34) beta-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01635">
        <property type="entry name" value="Glycosyltransferase_GTB-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051862">
        <property type="entry name" value="GT-like_domain_containing_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022701">
        <property type="entry name" value="QTMAN_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13615">
        <property type="entry name" value="GLYCOSYLTRANSFERASE-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13615:SF3">
        <property type="entry name" value="GLYCOSYLTRANSFERASE-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12038">
        <property type="entry name" value="QTMAN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="tRNA-queuosine alpha-mannosyltransferase N-terminal" evidence="10">
        <location>
            <begin position="3"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="9">
        <location>
            <begin position="293"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005026730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="503" mass="57369" checksum="B68E0F520C232002" modified="2022-01-19" version="1">MSVLLIEAFYGGSHKQLMDLLQEELKEECVLCTLPAKKWHWKARTAALYFMQTVPASANYRILFASSVLNLAELAALRPDLGKLKKVLYFHENQLAYPVQKCKERDFQYGYNQILSCLVADIVVFNSAFNMESFLTSIGKFMKLIPDHRPKDLEKIIRPKCQVLYFPVRFPDVSRFMPEHKLAHLENIIGVKRNGDSYQGEGLPGQQKSRALGGLMKNSNEHRESGLCETQPGLCTTQHEGLHSPLTAAGRLSQSEASESTNSCQEEDKQHVTFNLCNIWSGTDYQQRPLHVVWPHRWEHDKDPETFFKVLLKLKEQELPFHVSVLGETFTDVPDIFAEAKKALGSSVLHWGYLPSKDDYFQALCMADVVVSTAKHEFFGVAMVEAVHCGCYPLCPKALVYPEIFPAEYLYSTPEQLFKRLQNFCKRPDIVRKHLYKVHDSAGSTIPTAWTQLKMALWKAAVLVERYFPLGESVLTADNLLLWVISWDACGQHSLLHHHHPHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UFT6</accession>
    <name>A0A8C2UFT6_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Interleukin-5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Eosinophil differentiation factor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">T-cell replacing factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC107320068</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="12">Homodimer; disulfide-linked. Interacts with IL5RA. Interacts with CSF2RB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IL-5 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2UFT6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005036585.1">
        <property type="protein sequence ID" value="ENSCJPP00005027011.1"/>
        <property type="gene ID" value="ENSCJPG00005020981.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000235516"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005137">
        <property type="term" value="F:interleukin-5 receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009079">
        <property type="entry name" value="4_helix_cytokine-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000186">
        <property type="entry name" value="IL-5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48491">
        <property type="entry name" value="INTERLEUKIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48491:SF1">
        <property type="entry name" value="INTERLEUKIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02025">
        <property type="entry name" value="IL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00432">
        <property type="entry name" value="INTERLEUKIN5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47266">
        <property type="entry name" value="4-helical cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0202">Cytokine</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0339">Growth factor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005027011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="186" mass="21531" checksum="5048BA4DE75E1FA4" modified="2022-01-19" version="1">MAQLNTSSYLENDQMRGRIYQMGRNAHHIIAAFQREHARGHAMVEDSSRSTHWFSEHIRTMRTHLYLLLLTVGASAIPLRSNLAELQTWLQQIYQSAGTLNLRIETPVSTDDENCIKILFEGMDLLKNSPEMRRFSAFFQSFEKLKPSLTANLAEEGECDTERRNVKNFIEKLRTFIRKLSRGARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UH01</accession>
    <name>A0A8C2UH01_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Signal recognition particle subunit SRP68</fullName>
            <shortName evidence="12">SRP68</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">SRP68</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the SRP68 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2UH01"/>
    <dbReference type="Ensembl" id="ENSCJPT00005036247.1">
        <property type="protein sequence ID" value="ENSCJPP00005026748.1"/>
        <property type="gene ID" value="ENSCJPG00005020799.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000011856"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005047">
        <property type="term" value="F:signal recognition particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009410">
        <property type="term" value="P:response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15481">
        <property type="entry name" value="SRP68-RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3450.40:FF:000001">
        <property type="entry name" value="Signal recognition particle subunit SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3450.40">
        <property type="entry name" value="Signal recognition particle, SRP68 subunit, RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026258">
        <property type="entry name" value="SRP68"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034652">
        <property type="entry name" value="SRP68-RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038253">
        <property type="entry name" value="SRP68_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12860">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 68 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12860:SF0">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16969">
        <property type="entry name" value="SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038995">
        <property type="entry name" value="SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8 12" id="KW-0733">Signal recognition particle</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR038995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005026748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="656" mass="74749" checksum="193934E835C49CC4" modified="2022-01-19" version="1">MGPTHQAWVLRDPITPRGAGRSIRFVCARLYCPSPQCTAASAARVQDGGGAAGRARRGGGEQGERTAGGNRECRTDSTLYCQSALTQIPVLQIVKESQQQHGLRHGDFQRYRGYCSRRLRRLRKTLNFKMGNRHKFTGKKVTEEILSDNRYLLLILMDAERAWSYAMQLKQEANTEPRKRFHLLSRLRKAVKHAEELERLCESNRVDAKTKLEAQAYMAYLTGMLRFEHQEWKAAMEVTAFNQETIYEKLANAFTEEQAVLYNQRVEEISPNIRYCAYNIGDQSAMNELMQMRLRSGGTEGLLAEKLEALITQTRAKQAATMSEVEWRGRTVPVKIDRVRIFLLGLADNEAAIVQAENEETRERLFESLLSECRDAIQAVREDLKPDQKQREHSLESDSGKVSNMQYLHSYLTYIKLSTAIKRNESMAKSLQKALLQQQRSEEDGKRTPRPQDLIRLYDIILQNLVELTQLPGLEEDKNFQKEIGLKTLVYKAYRCFFIAQSYVLVKKWSEALVLYERVLKYAGEVQSEAGAFTNSLKELPDVQDLITQVNAEKYSLQAAAILDANDNHETESPSQVKDGKPLSERFETFCLDPSLVSKQVNLVHFPPGFQPIPCKPLFFDLALNHVAFPPLEDKVEQKAKSGLTGYIKGIFGFKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y6K3</accession>
    <name>A0A8C2Y6K3_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y6K3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005006490.1">
        <property type="protein sequence ID" value="ENSCJPP00005003698.1"/>
        <property type="gene ID" value="ENSCJPG00005003843.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00900000141067"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47960">
        <property type="entry name" value="DEAD-BOX ATP-DEPENDENT RNA HELICASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="8">
        <location>
            <begin position="81"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="112"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="81"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005003698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="194" mass="21826" checksum="8498AA12537F80F7" modified="2022-01-19" version="1">FFTSWLERPPFASLSSLPDHCLTQQQMNQLKNANTINNGTQQQAQSMTTTIKPGNDWKKTLKLPPKDLRIKTSDVTSTKGNEFEDYCLKRELLMGIFEMGWEKPSPIQEESIPIALSGRDILARAKNGTGKSGAYLIPLLERLDLKKDNIQAMVIVPTRELALQVSQICIQAITVCIQVLGTRKDSYQDSCREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y6K6</accession>
    <name>A0A8C2Y6K6_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">CUGBP Elav-like family member 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">CELF2</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CELF/BRUNOL family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015723479.1">
        <property type="nucleotide sequence ID" value="XM_015867993.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y6K6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005007151.1">
        <property type="protein sequence ID" value="ENSCJPP00005004225.1"/>
        <property type="gene ID" value="ENSCJPG00005004245.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107316324"/>
    <dbReference type="CTD" id="10659"/>
    <dbReference type="GeneTree" id="ENSGT00940000155461"/>
    <dbReference type="OrthoDB" id="410044at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106222">
        <property type="term" value="F:lncRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006376">
        <property type="term" value="P:mRNA splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd12631">
        <property type="entry name" value="RRM1_CELF1_2_Bruno"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12634">
        <property type="entry name" value="RRM2_CELF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12638">
        <property type="entry name" value="RRM3_CELF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000013">
        <property type="entry name" value="CUGBP Elav-like family member 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000015">
        <property type="entry name" value="CUGBP Elav-like family member 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000016">
        <property type="entry name" value="CUGBP Elav-like family member 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034196">
        <property type="entry name" value="CELF1/2_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034198">
        <property type="entry name" value="CELF1/2_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034199">
        <property type="entry name" value="CELF1/2_RRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 9" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="58"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="150"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="441"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005004225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="526" mass="56269" checksum="A50DCF7FD8F4F699" modified="2022-01-19" version="1">MFERTSELAFVENIGAESMRCPKSAVTMRNEELLLSNGTANKMNGALDHSDQPDPDAIKMFVGQIPRSWSEKELKELFEPYGAVYQINVLRDRSQNPPQSKGCCFVTFYTRKAALEAQNALHNIKTLPGMHHPIQMKPADSEKSNAVEDRKLFIGMVSKKCNENDIRVMFSPFGQIEECRILRGPDGLSRGCAFVTFSTRAMAQNAIKAMHQSQTMEGCSSPIVVKFADTQKDKEQRRLQQQLAQQMQQLNTATWGNLTGLGGLTPQYLALLQQATSSSNLGAFSGIQQMAGMNALQLQNLATLAAAAAAAQTSATTTNANPLSTTTGALGALTSPVAASTANSTAGAAMNSLTSLGTLQGLAGATVGLNNINALAGMAALNGGLGATGLTNGTAGTMDALTQAYSGIQQYAAAALPTLYSQSLLQQQSAAGSQKEGPEGANLFIYHLPQEFGDQDILQMFMPFGNVISAKVFIDKQTNLSKCFGFVSYDNPVSAQAAIQAMNGFQIGMKRLKVQLKRSKNDSKPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y6M7</accession>
    <name>A0A8C2Y6M7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Zinc finger protein 143</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Selenocysteine tRNA gene transcription-activating factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">ZNF143</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GLI C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015719535.1">
        <property type="nucleotide sequence ID" value="XM_015864049.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015719537.1">
        <property type="nucleotide sequence ID" value="XM_015864051.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015719538.1">
        <property type="nucleotide sequence ID" value="XM_015864052.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y6M7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005006659.1">
        <property type="protein sequence ID" value="ENSCJPP00005003830.1"/>
        <property type="gene ID" value="ENSCJPG00005003817.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107314613"/>
    <dbReference type="KEGG" id="cjo:107314613"/>
    <dbReference type="CTD" id="7702"/>
    <dbReference type="GeneTree" id="ENSGT00940000157584"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000071">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000125">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000137">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000142">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000072">
        <property type="entry name" value="zinc finger protein 143 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000236">
        <property type="entry name" value="zinc finger protein 143 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000016">
        <property type="entry name" value="zinc finger protein 37 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0010">Activator</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="236"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="266"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="296"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="326"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="356"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="386"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="416"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00067483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00083853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005003830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="637" mass="68914" checksum="F6C2473AA8F111E9" modified="2022-01-19" version="1">MLLAQINRDSQGMTEFSGGGMEAQHVTLCLTEAVAVQDGDNLENMEGVSLQAVTLADGSTAYIQHNSKDGKLMDGQVIQLEDGSAAYVQHVPMTKSRDSLRLEDGQAVQLEDGTTAFIHHTSKDSYDQSALQAVQLEDGTTAYIHHAVQMPQSDTILAIQADGTVAGLHTGDAAIDPDTITALEQYAAKVSIDGNDSVSSTAMIGENEQEKKMQIVLQGHGTRVAAKSQQSGEKAFRCDYDGCGKLYTTAHHLKVHERSHTGDRPYQCEHPGCGKAFATGYGLKSHIRTHTGEKPYRCTEENCTKSFKTSGDLQKHIRTHTGERPFKCPFEGCGRSFTTSNIRKVHIRTHTGERPYYCTEPGCGRAFASATNYKNHVRIHTGEKPYVCTVPGCDKRFTEYSSLYKHHVVHTHSKPYNCNHCGKTYKQISTLAMHKRTAHNDTEPIEEEQEAFFEPPPGQGEDVLKGSQIAYVTGVEGEDVISAQVATVTQSGLGQQVALIAQDGTQHVNISQADMQAIGNTITMVTQDGTTITVPAHDAVISSAGTHSVAMVTAEGTEGQQVAIVAQDLAAFHSTSSEIGHQQHGHHLVTTEARPVTLLATSNGTQIAVQLGEQQSLEEAIRIASRIQQGETPGIDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y7R3</accession>
    <name>A0A8C2Y7R3_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cytokine-inducible SH2-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">CISH</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015729992.1">
        <property type="nucleotide sequence ID" value="XM_015874506.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y7R3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005009851.1">
        <property type="protein sequence ID" value="ENSCJPP00005006227.1"/>
        <property type="gene ID" value="ENSCJPG00005005848.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107319571"/>
    <dbReference type="KEGG" id="cjo:107319571"/>
    <dbReference type="CTD" id="1154"/>
    <dbReference type="GeneTree" id="ENSGT00940000157392"/>
    <dbReference type="OrthoDB" id="10063348at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005942">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046935">
        <property type="term" value="F:1-phosphatidylinositol-3-kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001960">
        <property type="term" value="P:negative regulation of cytokine-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd10718">
        <property type="entry name" value="SH2_CIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03734">
        <property type="entry name" value="SOCS_CIS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000042">
        <property type="entry name" value="Cytokine-inducible SH2-containing protein b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.750.20:FF:000002">
        <property type="entry name" value="Suppressor of cytokine signaling 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.750.20">
        <property type="entry name" value="SOCS box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035887">
        <property type="entry name" value="CIS_SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036036">
        <property type="entry name" value="SOCS_box-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10155:SF9">
        <property type="entry name" value="CYTOKINE-INDUCIBLE SH2-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10155">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00253">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158235">
        <property type="entry name" value="SOCS box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0341">Growth regulation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="4" id="KW-0734">Signal transduction inhibitor</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SH2" evidence="9">
        <location>
            <begin position="93"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="10">
        <location>
            <begin position="209"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="258" mass="29161" checksum="1FD1EA28266067D4" modified="2022-01-19" version="1">MLFPWPGSDMILCVPGPHPLLAEEKIQRLSLHGIAEDLTEHIMQPLPVPAFPEEPAPTFAAPEPDSSAPQTRDPEEDLLCIAKTFSYLRESGWYWGSITASEAKQHLQKMPEGTFLVRDSTHPSYLFTLSVKTNRGPTNVRIEYADSKFRLDSNYLSKPRILAFPDVVSLIQHYVTSCTTESKSEAPYPPPAPLPPVQKEVAVAAVHLKLLRPLGRRDSIPSLQHLCRLRINRCTTEVERLPLPRRMGDYLKQYPFQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y864</accession>
    <name>A0A8C2Y864_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">SKI2 subunit of superkiller complex</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">SKIC2</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y864"/>
    <dbReference type="Ensembl" id="ENSCJPT00005011619.1">
        <property type="protein sequence ID" value="ENSCJPP00005007510.1"/>
        <property type="gene ID" value="ENSCJPG00005006849.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158255"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
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        <property type="term" value="C:Ski complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0034458">
        <property type="term" value="F:3'-5' RNA helicase activity"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0070478">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ATP-dependent RNA helicase SKI2"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.40.50.300:FF:000447">
        <property type="entry name" value="helicase SKI2W isoform X2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Ski2 ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025696">
        <property type="entry name" value="Beta-barrel_MTR4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2/MTR4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13234">
        <property type="entry name" value="MTR4_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="359"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="641"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="259"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="571"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="259"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="277"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
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            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
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        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005007510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1247" mass="135913" checksum="7D5269AABB6DC08C" modified="2022-01-19" version="1">MGRGRVCGPCGGCEDLWGLWSLWRGLCGAWRGCTVLWGSDSPLCYFALSPPIALPPPGPLHLPLALLELGCAGRYELLPGPAPPRSTLPQGLPPFAPSLTEELEQRFLGTPSWLPPHQHERAQRCWTRVPNPRALFVLEPTPVHSSMRALRDPGTGALQGEHPQTPPPFNTCCPPFCVSPKADPYPRPLTPIFVTFPGGLEEPPLELLHTQGPNEENLDFENDLLTIPPGLKRGVEFQPRGAPSLCSVLGALDSLELERAEEEEKKEGEAAGGGAPSQPPPDKGGLPSPTPPLRRADSLEELVLVPPTTATPPALPQSEEEEWAVEEDCSVPVENFEEKIPDPAFKWPFRPDAFQQRAALCLERGQSLLVAAHTSAGKTAVAEYAIALARRHMTRAIYTSPIKALSNQKFRDFRATFGDVGLLTGDVQLRPDASCLIMTTEILRSMLYNGSEVLRELEWVIFDEVHYINDAERGVVWEETLILLPEHVGLVLLSATIPNALEFAQWVGRTKRRRLRVLSTRRRPVPLEHYLYTGGGGPPSPHDLFLLLDASGGFSTQGYYAAVEAQKQRASKHSQSFGAKQPHGGGSGPGQDRAMWHSLVALLQAQGQLPAVAFTFSRGRCDANATALGRIDLSSAAEKGRVRSFVRRCLARLRGGDRCLPQVLQMSELLERGIGVHHSGVLPLLKEVVEMLFSQGLVKLLFATETFAMGVNMPARTVVFDSIRKHDGNNFRDLLPGEYVQMSGRAGRRGLDRTGTVIILCRGTVPDMADLHRHTLSILQRAAALSVEGLMRNSFGEFPLRRRAQRRVAELQQELAALGEPPDKETLDDLPQYHEAVQGLLEARAELQRRVAQSVAGLKALAPGRVVVVCTPQHRNALGLILQVQPPPQSTPTSPKVTPEHSNITLQHLHVLKITPEDNEFGVGVFFPLGLFIGGVCGGSGAPWCFIPPFISSRKDPPSPELLSALQELLRMAGGAPGGLPLLDPVGALQLRDPPAVEAAARARSLGAALGGFRCVHGPRFPQLYSQFAARRRLQDQVEQLQYQLSDRSLLLLPEYRQRLGVLQALGYVADGGAVQLPGRVAALLSCHELLLTELLLGNVLSPLRPEEVAALLSCTVHPGRGEPPPKLPPNLQKGMEQIRAVAERVGRLQEEWGLPQSAEDYVGQFGFGLAEVVYEWARGMPFAALAALAPLQEGVVVRCIQRLEELCRELRRAARMLGDPGLAATMEAASGCIKRDIVFAASLYIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y883</accession>
    <name>A0A8C2Y883_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">H2AZ1</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="10">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the histone H2A family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y883"/>
    <dbReference type="Ensembl" id="ENSCJPT00005011752.1">
        <property type="protein sequence ID" value="ENSCJPP00005007618.1"/>
        <property type="gene ID" value="ENSCJPG00005006976.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00900000140979"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000791">
        <property type="term" value="C:euchromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000792">
        <property type="term" value="C:heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031492">
        <property type="term" value="F:nucleosomal DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000979">
        <property type="term" value="F:RNA polymerase II core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071392">
        <property type="term" value="P:cellular response to estradiol stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000005">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 10" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="12">
        <location>
            <begin position="12"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="13">
        <location>
            <begin position="98"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005007618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="131" mass="13927" checksum="FB23635AB47446DB" modified="2022-01-19" version="1">MRSTAGGKAGKDSGKTKTKAVSRSQRAGLQFPVGRIHRHLKSRTTSHGRVGATAAVYSAAILEYLTAEVLELAGNASKDLKVKRITPRHLQLAIRGDEELDSLIKATIAGGGVIPHIHKSLIGKKGQQKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y8L5</accession>
    <name>A0A8C2Y8L5_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein Spindly</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Coiled-coil domain-containing protein 99</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Spindle apparatus coiled-coil domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">SPDL1</name>
        <name evidence="8" type="synonym">CCDC99</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Chromosome</location>
            <location evidence="8">Centromere</location>
            <location evidence="8">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the Spindly family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015731434.1">
        <property type="nucleotide sequence ID" value="XM_015875948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y8L5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005012313.1">
        <property type="protein sequence ID" value="ENSCJPP00005008052.1"/>
        <property type="gene ID" value="ENSCJPG00005007277.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107320249"/>
    <dbReference type="KEGG" id="cjo:107320249"/>
    <dbReference type="CTD" id="54908"/>
    <dbReference type="GeneTree" id="ENSGT00510000047951"/>
    <dbReference type="OrthoDB" id="2121607at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000940">
        <property type="term" value="C:outer kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043515">
        <property type="term" value="F:kinetochore binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007080">
        <property type="term" value="P:mitotic metaphase chromosome alignment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03041">
        <property type="entry name" value="SPDLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028593">
        <property type="entry name" value="SPDLY_chordates"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051149">
        <property type="entry name" value="Spindly/BICDR_Dynein_Adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32123">
        <property type="entry name" value="BICD FAMILY-LIKE CARGO ADAPTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32123:SF9">
        <property type="entry name" value="PROTEIN SPINDLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 8" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 8" id="KW-0137">Centromere</keyword>
    <keyword evidence="1 8" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 8" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="3 8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="487"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="527"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="6"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="163"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="490"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="527"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="539"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="556"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="588"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005008052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="602" mass="70299" checksum="2CFA083C5E4DE334" modified="2022-01-19" version="1">METETILNLRQQLKEAENERRKAAQYGLHLLESQNEIQNQLDQIRRELTEKTEIFEQEKYSLQREIELKNRMLESLSFECDALKQQQNVQLDKQKEQLARAHGQEVNDLKCKLENLKAELDETRLSEKQLRHKVDHQKEIIAAKTEELHMMSERVHETMSSEMLNLQMELTELESVKANVEEKLNELQYSKEQLELINSNLRNQLERLQGEKEEREKEVVSYCNALEKAREANQELQVQLDHVVQQSLDPTSKGNSLFAEVEDRRAEMERQLISVKIKYQSLQKQHAFTREQLQRMKLQMATLLQMKGSQAEFEQLERLQSMLEQKNGEIEDLLVKVRQLEKFKTLYENMEECRASTSSKGGESEDGYYADLLQMKLDNSNKETETLKNELSLQRMKALYESQRVLEVERKLFTNERQLQACQSENMNLRVMLDELKMKYEPEELLKVTKIKKKREKIPVDATCEYLDSKNASVNEAPLTHLPCKEEAKTTSSNLEQIDSSSKKQTLEASPINVGLQSTDKVVEPERKRVKTKDDSLDTCRSGSNFLTSSAPRLTTESRFEATEMEDKKENVITTKKKRQKEKYATLYVSSKPTPETQCAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YAM3</accession>
    <name>A0A8C2YAM3_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Dystroglycan 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="24">Dystroglycan</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">Dystrophin-associated glycoprotein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="30" type="primary">DAG1</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="30" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="30" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="30" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="20">The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization.</text>
    </comment>
    <comment type="function">
        <text evidence="21">Transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <location evidence="1">Sarcolemma</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="25">Postsynaptic cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015730051.1">
        <property type="nucleotide sequence ID" value="XM_015874565.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015730052.1">
        <property type="nucleotide sequence ID" value="XM_015874566.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015730053.1">
        <property type="nucleotide sequence ID" value="XM_015874567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015730054.1">
        <property type="nucleotide sequence ID" value="XM_015874568.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015730055.1">
        <property type="nucleotide sequence ID" value="XM_015874569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YAM3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005017894.1">
        <property type="protein sequence ID" value="ENSCJPP00005012337.1"/>
        <property type="gene ID" value="ENSCJPG00005010491.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107319593"/>
    <dbReference type="KEGG" id="cjo:107319593"/>
    <dbReference type="CTD" id="1605"/>
    <dbReference type="GeneTree" id="ENSGT00390000008429"/>
    <dbReference type="OrthoDB" id="5990676at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070938">
        <property type="term" value="C:contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016011">
        <property type="term" value="C:dystroglycan complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030175">
        <property type="term" value="C:filopodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051393">
        <property type="term" value="F:alpha-actinin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043236">
        <property type="term" value="F:laminin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042169">
        <property type="term" value="F:SH2 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008307">
        <property type="term" value="F:structural constituent of muscle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017166">
        <property type="term" value="F:vinculin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001618">
        <property type="term" value="F:virus receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071711">
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        <property type="term" value="P:morphogenesis of an epithelium"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="alpha_DG_C"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Dystroglycan_repeat"/>
        <property type="match status" value="2"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="Alpha-dystroglycan_domain_2"/>
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        <property type="entry name" value="Alpha_DG1_N2"/>
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        <property type="entry name" value="Cadg"/>
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        <property type="entry name" value="Cadherin-like_sf"/>
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        <property type="entry name" value="DAG1_C"/>
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        <property type="entry name" value="Ig-like_fold"/>
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        <property type="entry name" value="SEA_DG_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21559:SF22">
        <property type="entry name" value="DYSTROGLYCAN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21559">
        <property type="entry name" value="DYSTROGLYCAN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18424">
        <property type="entry name" value="a_DG1_N2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Cadherin-like"/>
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    </dbReference>
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    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="17" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14 27" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0964">Secreted</keyword>
    <keyword evidence="11 28" id="KW-0732">Signal</keyword>
    <keyword evidence="13" id="KW-0770">Synapse</keyword>
    <keyword evidence="10 27" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 27" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="28">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034207262" description="Dystroglycan 1" evidence="28">
        <location>
            <begin position="29"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="750"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S72" evidence="29">
        <location>
            <begin position="604"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="317"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
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            <begin position="341"/>
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        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="26">
        <location>
            <begin position="433"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="26">
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            <begin position="448"/>
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        </location>
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            <begin position="860"/>
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    </evidence>
    <sequence length="896" mass="97881" checksum="BE4CDF5DE0F6C309" modified="2022-01-19" version="1">MTVGCVLQPPFLGRTLLPVLLLAASARCHWPSEPGEVVRDWENQLEASMHSVLSDLRETVPAVVGIPDSSAVVGRFFRVSIPTDLIASNGEVVQVSEAGKESLPSWLHWNAESSSLEGLPLDTDKGVHYISVTTLQPFPNGSYVPQAANVFSVEVHQEDHSEPQSVRAAAQDVGDAAPFVCGAEEPVTILTVILDADLTKMTPKQRIELLNRMRSFSEVELHNMKLVPVVNNRLFDMSAFMAGPGNAKKVVENGALLSWKLGCSLSQNSVPNISKVEAPAKEGTMSARLGYPVVGWHIANKKPHLPKRMRRQINATPTPLTAIGPPTTAAQEPPTRIVPTPTSPAIAPPTETTAPPVREPIPLPRKPTVTIRTRGPIVQTPTLGPIQPTRLVEGTGTVSVPIRPTMPGYVEPTAVITPPTTTTKKPRVSTLKPATPSTTDSSTATTRRPTRRPKTPRPTKPPSTTRSPISKLTTASPPTRVRTTASGIPRPWEPNEPPKLTNHIDRVDAWEGTYFEVKIPSDTFYDKEDTTTDKLQLTLKLKEQQMIEENSWVQFNSTSQLMYGMPDRSHVGKHEYFMYATDKGGLFAVDAFEIHVHKRPHGDKSPVKFKARLEGDHNAVANDIHKKIMLVKKLALAFGDRNSSTITVQDITKGSIVVEWTNNTLPLEPCPREQIRTLSRKIADDSGGPSPAFSNILQPEFKPLNVSVVGSGSCRHIQFVPVTKDGRVISEATPTLAAGKDPEKSSEDDVYLHTVIPAVVVAAILLVAGIIAMICYRKKRKGKLTIEDQATFIKKGVPIIFADELDDSKPPPSSSMPLILQEEKAPLPPPEYPNQSMPETTPLNQDTIGEYTPLRDEDPNAPPYQPPPPFTAPMEGKGSRPKNMTPYRSPPPYVPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YB01</accession>
    <name>A0A8C2YB01_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Arginine-glutamic acid dipeptide repeats protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">RERE</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="Ensembl" id="ENSCJPT00005019269.1">
        <property type="protein sequence ID" value="ENSCJPP00005013407.1"/>
        <property type="gene ID" value="ENSCJPG00005011268.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153615"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048755">
        <property type="term" value="P:branching morphogenesis of a nerve"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021930">
        <property type="term" value="P:cerebellar granule cell precursor proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021691">
        <property type="term" value="P:cerebellar Purkinje cell layer maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048813">
        <property type="term" value="P:dendrite morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021942">
        <property type="term" value="P:radial glia guided migration of Purkinje cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd04709">
        <property type="entry name" value="BAH_MTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11661">
        <property type="entry name" value="SANT_MTA3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000052">
        <property type="entry name" value="Arginine-glutamic acid dipeptide (RE) repeats"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.490:FF:000005">
        <property type="entry name" value="Arginine-glutamic acid dipeptide (RE) repeats"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1240.50:FF:000003">
        <property type="entry name" value="Arginine-glutamic acid dipeptide (RE) repeats a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002951">
        <property type="entry name" value="Atrophin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000949">
        <property type="entry name" value="ELM2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
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        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13859:SF12">
        <property type="entry name" value="ARGININE-GLUTAMIC ACID DIPEPTIDE REPEATS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13859">
        <property type="entry name" value="ATROPHIN-RELATED"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF03154">
        <property type="entry name" value="Atrophin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <dbReference type="Pfam" id="PF00320">
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        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="103"/>
            <end position="264"/>
        </location>
    </feature>
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            <begin position="265"/>
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            <begin position="372"/>
            <end position="424"/>
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            <begin position="1"/>
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            <begin position="523"/>
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            <begin position="1157"/>
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            <begin position="1"/>
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            <begin position="74"/>
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            <begin position="460"/>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YBA7</accession>
    <name>A0A8C2YBA7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sprouty-related, EVH1 domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">SPRED2</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Secretory vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015712020.1">
        <property type="nucleotide sequence ID" value="XM_015856534.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YBA7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005019674.1">
        <property type="protein sequence ID" value="ENSCJPP00005013724.1"/>
        <property type="gene ID" value="ENSCJPG00005011544.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107310680"/>
    <dbReference type="KEGG" id="cjo:107310680"/>
    <dbReference type="CTD" id="200734"/>
    <dbReference type="GeneTree" id="ENSGT00940000156841"/>
    <dbReference type="OrthoDB" id="5786858at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030658">
        <property type="term" value="C:transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10574">
        <property type="entry name" value="EVH1_SPRED-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000052">
        <property type="entry name" value="Sprouty-related, EVH1 domain containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023337">
        <property type="entry name" value="KBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041937">
        <property type="entry name" value="SPRE_EVH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007875">
        <property type="entry name" value="Sprouty"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000697">
        <property type="entry name" value="WH1/EVH1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11202:SF11">
        <property type="entry name" value="SPROUTY-RELATED, EVH1 DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11202">
        <property type="entry name" value="SPROUTY-RELATED, EVH1 DOMAIN-CONTAINING PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05210">
        <property type="entry name" value="Sprouty"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00568">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00461">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51488">
        <property type="entry name" value="KBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51227">
        <property type="entry name" value="SPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50229">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="WH1" evidence="10">
        <location>
            <begin position="12"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="KBD" evidence="11">
        <location>
            <begin position="208"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="134"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="153"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005013724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="419" mass="47794" checksum="CDE84B133E462B4B" modified="2022-01-19" version="1">MSRDGEKMTEDAYPDDDSYIVRVKAVVMTRDDSSGGWLPQEGGGLSRVGVCKVTYPEGNGRSGFLIHGERQKDKLVVLECFVKKDLVYTKANPTFHHWKVDNRKFGLTFQSPADARAFDRGVRKAIEDLIEGSTTSSSTLHNEAEVGDDDVFTNATDSSSNSSQKREQPVRTLASPASCENRRICTRGHLHDHYTSDHYHLEQSVPRSYRHVNFPDDDEEIVRINPREKIWMTGYEDYRHAPARGKNFDPDDMDSYVRFAKSESSKHEYTYPYVDNSDFDLGEDIKGAVIKTQPVKFKPRRKEDGERSRCVYCRDMFNHEENKRGQCQDAPDRIKTCIHRVSCMWCADTMLYHCMSDPEGDFTDPCSCDTSDEMFCLRWMALIALSFIAPCMCCYLPLRACYHCGVMCRCCGGKHKAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YC66</accession>
    <name>A0A8C2YC66_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein kinase AMP-activated non-catalytic subunit gamma 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">PRKAG3</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="5">AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non-catalytic subunits (PRKAG1, PRKAG2 or PRKAG3). Interacts with FNIP1 and FNIP2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-AMP-activated protein kinase gamma subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2YC66"/>
    <dbReference type="Ensembl" id="ENSCJPT00005022423.1">
        <property type="protein sequence ID" value="ENSCJPP00005015871.1"/>
        <property type="gene ID" value="ENSCJPG00005013106.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183019"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031669">
        <property type="term" value="P:cellular response to nutrient levels"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04618">
        <property type="entry name" value="CBS_euAMPK_gamma-like_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04641">
        <property type="entry name" value="CBS_euAMPK_gamma-like_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.580.10:FF:000004">
        <property type="entry name" value="Protein kinase AMP-activated non-catalytic subunit gamma 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050511">
        <property type="entry name" value="AMPK_gamma/SDS23_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780:SF31">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT GAMMA-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780">
        <property type="entry name" value="AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CBS" evidence="8">
        <location>
            <begin position="85"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="8">
        <location>
            <begin position="167"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="8">
        <location>
            <begin position="242"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="8">
        <location>
            <begin position="314"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="28"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="376" mass="42273" checksum="AABA5ACCEC9D104A" modified="2022-01-19" version="1">MEQLSSPAAPQVPSGRVGGVPTGFPEALHPRGEEKEEEKQKGSRPVSFTLGNEILGLEPDNNFQTPDAEVYMHFMRSHCCYDAVPTSCKLVVFDTTLEIKKAFFALVANGVRAAPLWDSKVQSFVGMLTITDFINILHRYYRSPLVQIYEVEEHKIETWREVYLQGSFKPLVYISPSDSLFDAVYSLIKHKIHRLPVIEPISGNVLHILTHKRILKFLHIFGSTIPKPRFLKKTVQELCVGTFRDVAVVPENAPVYAALEIFVDRRVSALPVVNAAGQVVGLYSRFDVIHLAAQKTYNNLDISVREALRQRTVCLEGVLTCYPHETMEDIIDRIAEEQVHRLVLVDENRYPRGIVSLSDILQALVLTPAGIDALNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YC94</accession>
    <name>A0A8C2YC94_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Sodium/hydrogen exchanger</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC107306704</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2YC94"/>
    <dbReference type="Ensembl" id="ENSCJPT00005022587.1">
        <property type="protein sequence ID" value="ENSCJPP00005016029.1"/>
        <property type="gene ID" value="ENSCJPG00005013211.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156807"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098719">
        <property type="term" value="P:sodium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004709">
        <property type="entry name" value="NaH_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001953">
        <property type="entry name" value="NHE-2/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032103">
        <property type="entry name" value="NHE_CaM-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00840">
        <property type="entry name" value="b_cpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="SODIUM/HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110:SF89">
        <property type="entry name" value="SODIUM_HYDROGEN EXCHANGER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16644">
        <property type="entry name" value="NEXCaM_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01086">
        <property type="entry name" value="NAHEXCHNGR2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0050">Antiport</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0915">Sodium</keyword>
    <keyword evidence="11 12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="6 12 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="15">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/hydrogen exchanger regulatory region" evidence="16">
        <location>
            <begin position="235"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="307"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="307"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="434"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="461"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF16644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005016029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="472" mass="54621" checksum="7D91330EFB693ADE" modified="2022-01-19" version="1">MTMNKYVEENVSQKSYTTIKYFMKMLSSVSETLIFIFMGVSTVGKNHEWNWAFVSFTLLFCLIWRALGVFVLTQIINVFRTIPLTFKDQFIIAYGGLRGAICFSLVFLLPPSVFPRKKLFITAVIVVIFFTVFIQGITIRPLVEFLDVKRSNKKQPAVSEEIYNRFFDHVKTGIEDVCGHWGHNFWRDKFKKFDNKYLRRLLIRENQPKSSIVSLYKKLEIKHAIEMAESGMISKVPSSVSLSEYHEGKIKPLSPTEMENMREILTKNLYQIRHRTMSYNRHSLAADANEKQAKEILIRRRHSLRESLRKTNSLSRERPAAANTKRFLSLPKNTKLPEKLRVRNKTSSRVGDSSDSEMDATTTVLNLRPRAGKILREQRLRQQRPPSEFSMEWKNEVDGSQNGRGEQQEPGSLPQPSIGFRQPLLTRPRFGTLSREDLTADHGLARPVPPPRLVRQASQGERPRSKPENQPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YDQ6</accession>
    <name>A0A8C2YDQ6_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Carboxypeptidase O</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">CPO</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Carboxypeptidase which preferentially cleaves C-terminal acidic residues from peptides and proteins. Can also cleave C-terminal hydrophobic amino acids, with a preference for small residues over large residues.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Apical cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the peptidase M14 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2YDQ6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005026208.1">
        <property type="protein sequence ID" value="ENSCJPP00005018910.1"/>
        <property type="gene ID" value="ENSCJPG00005015355.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161508"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000050">
        <property type="entry name" value="Carboxypeptidase O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.340">
        <property type="entry name" value="Metallocarboxypeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057246">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036990">
        <property type="entry name" value="M14A-like_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003146">
        <property type="entry name" value="M14A_act_pep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF19">
        <property type="entry name" value="CARBOXYPEPTIDASE O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02244">
        <property type="entry name" value="Propep_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00132">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="21">
        <location>
            <begin position="72"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="19">
        <location>
            <position position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00058352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00071404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005018910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="399" mass="45583" checksum="1B3325A16B70BC0A" modified="2022-01-19" version="1">MWKPLLPEDIRAGEDLHIRVPNPLVQEVKDSLDQRMISYKILIHDVQELVDQSTPEETSSHKQVPESYNYTQYHPMKEIYTWMAQIQQNNSELVTQHYLGETVENQTIYYLQISQPSDKTKKIIWMDCGIHAREWISPAFCQWFVKEILQNYESDPKIKKFLENLDLYILPVLNIDGYIYSWETERLWRKNRSPHMNGTCYGTDLNRNFNSSWGTVGASYNCSSEIFCGTGPESEPETKAVVQLIERKKSDILCFLTIHSYGQYILTPYGSTTEPPSNNEELMHVAQTAAAALAEKYGTSYQVGSTSLILYSNSGSSRDWAHMIGIPFSYTFELRDKGTYGFVLPPDQIQPTCEETMLAVTTIIDYVDQKYFPGGAMMLTSGTLGLSLCLTTVLMLTVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YE17</accession>
    <name>A0A8C2YE17_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rhotekin 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">RTKN2</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YE17"/>
    <dbReference type="Ensembl" id="ENSCJPT00005027112.1">
        <property type="protein sequence ID" value="ENSCJPP00005019595.1"/>
        <property type="gene ID" value="ENSCJPG00005015869.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157470"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030097">
        <property type="term" value="P:hemopoiesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001243">
        <property type="term" value="P:negative regulation of intrinsic apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901224">
        <property type="term" value="P:positive regulation of non-canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13249">
        <property type="entry name" value="PH_rhotekin2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012966">
        <property type="entry name" value="AHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051364">
        <property type="entry name" value="Cytokinesis/Rho-signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011072">
        <property type="entry name" value="HR1_rho-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21538">
        <property type="entry name" value="ANILLIN/RHOTEKIN RTKN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21538:SF21">
        <property type="entry name" value="RHOTEKIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08174">
        <property type="entry name" value="Anillin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51860">
        <property type="entry name" value="REM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="REM-1" evidence="3">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="239"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005019595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="393" mass="45062" checksum="839950A3DDDCF3ED" modified="2022-01-19" version="1">QEKMNFEIRIREGICKLLTVSTQKDQLLQAVKNLMVCNARIRAYRAELQNQREEPVSYIRIPLMWKGSEHFNNKEKSQRYAVFCLFRMGAEVFDTEVAIVDKAITDICFENVTIFDEAGPDFQVKVEVYSCCTEESLYIANTPKKLVKKLKTSLSKATGKKLKATLQEDDTDSILLSDPIIHGAKYSLLAYTTLGLESAEDGFRTHNLTITGNEESSFWLPLYGNMCCRLVAQPSCMARDMMAGFLNQQIGNVTGWRRLYCVLRGGKLFCYYSPEEIEAKVEPALTVSINKDTRIRSVDKDSKKRTNNFSVTNPVSGEAATQLFATDSREELHKWMEAFWQHFYDLSQWKHCCEELMKIEIMSPRKPPLFLTKEATSVYHDMSKWDLSFQVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YFC4</accession>
    <name>A0A8C2YFC4_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Arrestin domain containing 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ARRDC1</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015734174.1">
        <property type="nucleotide sequence ID" value="XM_015878688.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YFC4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005030750.1">
        <property type="protein sequence ID" value="ENSCJPP00005022440.1"/>
        <property type="gene ID" value="ENSCJPG00005017875.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107321619"/>
    <dbReference type="KEGG" id="cjo:107321619"/>
    <dbReference type="CTD" id="92714"/>
    <dbReference type="GeneTree" id="ENSGT00940000159652"/>
    <dbReference type="OrthoDB" id="7785529at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903561">
        <property type="term" value="C:extracellular vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990763">
        <property type="term" value="F:arrestin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990756">
        <property type="term" value="F:ubiquitin-like ligase-substrate adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006858">
        <property type="term" value="P:extracellular transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140112">
        <property type="term" value="P:extracellular vesicle biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045746">
        <property type="term" value="P:negative regulation of Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF176">
        <property type="entry name" value="ARRESTIN DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="3">
        <location>
            <begin position="162"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005022440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="421" mass="45900" checksum="2EC786ECCC681BCF" modified="2022-01-19" version="1">MGKVQLFEIRLGESRVIYSPGEPLAGTVTVRLSGSLQYRAIKVSCVGFCGVSNKINDTAWTVEEQYFNTTLSLADKGVLSAGEHNFSFQFLLPASAPTSFEGPFGKVLHQVKAVIDTPRFSKDYKCSKIFYVLCPLNLNDILDIEQPNTMSVTKKFNYKLVKSGNVVLTATSDLKGYIVGQVIQLRTDIENKSGRDTGAVVASLLQKVAYKSKRWIYDLRTIAEVEGSGVKAWKHAEWKEQILVPALPQSILQGCSLIHIDYYIQVSLKSPEVSVTLPIYIGNIAVNRVPLSPSRSVQHLPSAVVPSAPPEEEEAAGGYHPMDNVLIPTKSHSQQQPFSYAPGLSFQEADSEQTGSPNHPTLCLSTGATIPYYAEGNVVPVPTASSLILPPEYSTWGYPYEAPPSYEQSCSSANSSISNGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2026-01-28" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q8SEW6</accession>
    <name>Q8SEW6_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 17">NADH-ubiquinone oxidoreductase chain 4L</fullName>
            <ecNumber evidence="3 17">7.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18 20" type="primary">ND4L</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <geneLocation type="mitochondrion" evidence="18 20"/>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2001" name="Anim. Genet." volume="32" first="380" last="385">
            <title>Complete sequence of the Japanese quail (Coturnix japonica) mitochondrial genome and its genetic relationship with related species.</title>
            <authorList>
                <person name="Nishibori M."/>
                <person name="Hayashi T."/>
                <person name="Tsudzuki M."/>
                <person name="Yamamoto Y."/>
                <person name="Yasue H."/>
            </authorList>
            <dbReference type="PubMed" id="11736810"/>
            <dbReference type="DOI" id="10.1046/j.1365-2052.2001.00795.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <tissue evidence="18">Whole blood</tissue>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2021" name="Gene" volume="145841" first="0" last="0">
            <title>When good mitochondria go bad: Cyto-nuclear discordance in landfowl (Aves: Galliformes).</title>
            <authorList>
                <person name="Kimball R.T."/>
                <person name="Guido M."/>
                <person name="Hosner P.A."/>
                <person name="Braun E.L."/>
            </authorList>
            <dbReference type="PubMed" id="34274481"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Part of the enzyme membrane arm which is embedded in the lipid bilayer and involved in proton translocation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:29092"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Mitochondrion inner membrane</location>
            <topology evidence="17">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the complex I subunit 4L family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.2" evidence="3 17"/>
    <dbReference type="EMBL" id="AP003195">
        <property type="protein sequence ID" value="BAB62923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW574361">
        <property type="protein sequence ID" value="QXU59990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_572022.1">
        <property type="nucleotide sequence ID" value="NC_003408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SEW6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005000028.1">
        <property type="protein sequence ID" value="ENSCJPP00005000010.1"/>
        <property type="gene ID" value="ENSCJPG00005000028.1"/>
    </dbReference>
    <dbReference type="GeneID" id="804662"/>
    <dbReference type="KEGG" id="cjo:804662"/>
    <dbReference type="CTD" id="4539"/>
    <dbReference type="GeneTree" id="ENSGT00940000164968"/>
    <dbReference type="OrthoDB" id="6146597at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030964">
        <property type="term" value="C:NADH dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098803">
        <property type="term" value="C:respiratory chain complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902495">
        <property type="term" value="C:transmembrane transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.3510:FF:000002">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase chain 4L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001133">
        <property type="entry name" value="NADH_UbQ_OxRdtase_chain4L/K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039428">
        <property type="entry name" value="NUOK/Mnh_C1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11434:SF0">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 4L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11434">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT ND4L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00420">
        <property type="entry name" value="Oxidored_q2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0249">Electron transport</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="13 17 18" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11 17" id="KW-0520">NAD</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="8 17" id="KW-1278">Translocase</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 17" id="KW-0813">Transport</keyword>
    <keyword evidence="12 17" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00043911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU004419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="BAB62923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="QXU59990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005000010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="98" mass="10777" checksum="22555781EA1FAF1E" modified="2002-06-01" version="1">MSPLHFSFYSAFTFSSLGLAFHRTHLISALLCLESMMLSMFIPLSIWSVENQTPSFTIVPILMLAFSACEAGTGLAMLVASTRTHGSDHLHNLNLLQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SNY8</accession>
    <name>A0A8C2SNY8_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Poly(A) RNA polymerase mitochondrial-like central palm domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SNY8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005002600.1">
        <property type="protein sequence ID" value="ENSCJPP00005001570.1"/>
        <property type="gene ID" value="ENSCJPG00005001583.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159914"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF127">
        <property type="entry name" value="SPECKLE TARGETED PIP5K1A-REGULATED POLY(A) POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="2">
        <location>
            <begin position="12"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="506"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="547"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="506"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="555"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="579"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="601"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="662"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="674"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="685"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="697"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="708"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="720"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="731"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="743"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005001570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="930" mass="98014" checksum="677DF5A5BA8C5AD8" modified="2022-01-19" version="1">MDPIDLSSTPPEELLHLVASILRRCVPGVTHVRPVPSARRPVVKFCHKQSGLLGDVSIDNRLALHNTRFLKLCSEADPRVRPLVYAVRLWAKQQGLAGNPAGGGPLLTNYALTLLVLFFLQTRSPPVLPTVQELRELAGPQCIVMESGWDCSFPCDAASLPRSDNTQSATQRWIQSCSAAAKYCRSLQYSQKSTKGRSWGLIRLFQPGAVEPGGGGGGGGRSAFLIPIPLDDGDGLKGVCAAVVFVLRDVLRCDVGRRENGVGDNGAGCGVAEDTEILEDPKGASEVEPDVLEDPEVLEDPKVLEDPKGASKVEPEGLEDPEVLEDPKGSPMGDPKLQDPKVMGAPGMDPKVLEDPKVMEDPKLQDPKVMGAPGMDPKAFEDPRGLGALEMDPKAFEDPKLVGWCGTDPNLMAEDPKAIEVDLEDPKLVEASGTDPDIPLPSPLVGSKRPQPKGLDVTATPKAKRQRVADPIEEEEEEEEEEATRWSCSLWHRVWTGRRRLRRQLQHRDGTSRVHGDNSGIQCGDGGPNGIHRDTSRVCGDNSGIQCGDGGSNGIHRDTSRVHGDNSGIQCGDGGPNGIHRDTSRVRGDNSGVCGDGDANGIHRDTSGVRGDGDTNGIHGETSGIYGDISGVCGDGDTSRPPYGDGDPNGLHGDTSRVCGDTSGGCGDGGPNGLHRDTSRVRGDNSGGCGDGGPNGIHRDTSRVHGDNSGGCGDGGPNGIHRDTSRVRGDNSGGCGDGGPNGIHRDTSRVHGDNSGIQCGDGGSNGLHRDTSGVHGDTSGICGDGDTSRPQYGDGDPNGLHGDTSRVCGDTSGVCGDGGTSRPQYGAGAPTGLHVDTNGLYMDVDPCGPPDDLDLEQKVTAAILEQNGAAPLPAPLLRFHADVRLTLGGRRALLRLSPIPGPGPLFRDFFHFLRVFLPPLVRKRLIQPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SPH1</accession>
    <name>A0A8C2SPH1_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SPH1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005003084.1">
        <property type="protein sequence ID" value="ENSCJPP00005001822.1"/>
        <property type="gene ID" value="ENSCJPG00005001859.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01010000223816"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="252"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="330"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="385"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005001822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="551" mass="55275" checksum="62473278D0D1B3B2" modified="2022-01-19" version="1">MGGRAESVLAPRPSPTPVLMLVPSPTPALTLVPSPTPALTLVPSPTPALTLVPSPTPALTSVLSPTPALTSVPSPTLAPRAAPTAKPRADPMLEAPVPTPAPTVSPIPAPASSPGAELAPTLVLRPSPTPDPRAEPTAGLTLDPTAVPALTAEGRGVALLAAALSPIPTSTSDPRAEPTLAPTPAPTASPDPSVEPTLAPTPAPMPSPTPGPRVEPTLAPTPAPMLSPTPDPRVEPTLAPTPAPMASPTPGPMAAISAPRAAPTLGLLPAATPSPTSTLMPAPMSAPRPCPTSSPRPRPTSMPTVGSVLAPMPIPRPCPTPDPREGSTLAAVPAPSSMAAPSPDPTFVPCPTPAPIPGSMLAAALAPCPTSAPTLTPRPRPTAAPAPSSAPIMSSTPDPTPGPTSRPTPRAPAAPTSAPRKSKPGPKESGGPGGASAASCCRRHQASASLWEESGCQWCTEIMGSNVGHPWELHPPDDEVVGQQGRALGAQAGVDPRPAQAVLALQPRHQLPPRLRSCTRCGEKRGHQWGWGRRRGWGCGVGEAESSGDMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SPK8</accession>
    <name>A0A8C2SPK8_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Voltage-dependent calcium channel gamma-7 subunit</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SPK8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005003312.1">
        <property type="protein sequence ID" value="ENSCJPP00005001901.1"/>
        <property type="gene ID" value="ENSCJPG00005001982.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01050000244961"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032281">
        <property type="term" value="C:AMPA glutamate receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098839">
        <property type="term" value="C:postsynaptic density membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016247">
        <property type="term" value="F:channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005245">
        <property type="term" value="F:voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099590">
        <property type="term" value="P:neurotransmitter receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098943">
        <property type="term" value="P:neurotransmitter receptor transport, postsynaptic endosome to lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051968">
        <property type="term" value="P:positive regulation of synaptic transmission, glutamatergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098970">
        <property type="term" value="P:postsynaptic neurotransmitter receptor diffusion trapping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019226">
        <property type="term" value="P:transmission of nerve impulse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051072">
        <property type="entry name" value="CACNG_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008368">
        <property type="entry name" value="VDCC_gsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12107">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12107:SF12">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-7 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01792">
        <property type="entry name" value="VDCCGAMMA"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="1" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="1" id="KW-0407">Ion channel</keyword>
    <keyword evidence="1" id="KW-0406">Ion transport</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <keyword evidence="1" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="198"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005001901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="230" mass="25663" checksum="AC38F9FA5039AA0A" modified="2022-01-19" version="1">MRPRRPQKRPQKASKLPQMRPQKTPNLPQEASKDPKSSPKRGVWFGREVGDGVPLWGAMTPCPTETVRTATPFPMVSLFLVFTAFVISNVGHIRPQRTLLAFVCPLVVGLVLYISSINDEVMLNRPGGSEQYFQYRYGWSFAFAASSFLLKEGAGVMSVVPISRKRYAEEERFRSPSVLLVPSQCVFGLSGQFLQPRAWPRPRSPSGNRAYPAAIQYPGQGQGHLTSPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SQV3</accession>
    <name>A0A8C2SQV3_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="18">IKAROS family zinc finger 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">IKZF4</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the Ikaros C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015742403.1">
        <property type="nucleotide sequence ID" value="XM_015886917.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SQV3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005003330.1">
        <property type="protein sequence ID" value="ENSCJPP00005001911.1"/>
        <property type="gene ID" value="ENSCJPG00005001995.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107325762"/>
    <dbReference type="KEGG" id="cjo:107325762"/>
    <dbReference type="CTD" id="64375"/>
    <dbReference type="GeneTree" id="ENSGT00940000158308"/>
    <dbReference type="OrthoDB" id="8922241at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome LGE22C19W28_E50C23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043425">
        <property type="term" value="F:bHLH transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000073">
        <property type="entry name" value="IKAROS family zinc finger 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000525">
        <property type="entry name" value="IKAROS family zinc finger 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000124">
        <property type="entry name" value="IKAROS family zinc finger 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000372">
        <property type="entry name" value="IKAROS family zinc finger 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000168">
        <property type="entry name" value="zinc finger protein Eos isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050589">
        <property type="entry name" value="Ikaros_C2H2-ZF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404:SF28">
        <property type="entry name" value="ZINC FINGER PROTEIN EOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="112"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="168"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="201"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="394"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="404"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005001911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="524" mass="57620" checksum="1B4B141BC5F30983" modified="2022-01-19" version="1">MDIEDCNGRSYISGSGDSSLEKEFSSAIVGAAVSTPNSQHSSPSRSLSASSIKVEMYSDEEGSRLLAQDDRMLEKDDSVIVEDSLSEPLGYCDGPGQEPHSPGGIRLPNGKLKCDVCGMVCIGPNVLMVHKRSHTGERPFHCNQCGASFTQKGNLLRHIKLHSGEKPFKCPFCNYACRRRDALTGHLRTHSVSSPTVGKPYKCNYCGRSYKQRSSLEEHKERCHSYLQSLNTEPQALAGQQGDEMRDLEMVPDSLLHPSADRPTFIDRLANSLTKRKRSTPQKFVGEKQMRFALSDLPFEVNSGFEKDVEMVSAHHPLDPSYGSSLALMGGDHLRPLRLPPTNCISEVTPVISSVYTQLQPLPGRLELPGGRDAAEGHEDTADGAQALYRGREVGASPTNGCHDSTDTESIHEERTAQPPPGNGPGSRQSPAYAKEDPKMAEGAPRSTPSGGRDALRVVTEDGEPVRAFRCEHCRILFLDYVMFTIHMGCHGFRDPFECNVCGYRSQDRYEFSSHIVRGEHKVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SRH2</accession>
    <name>A0A8C2SRH2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">WIBG Mago-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts (via N-terminus) with magoh and rbm8a; the interaction is direct. Associates (eIF2A-like region) with the 40S ribosomal subunit and the 48S preinitiation complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the pym family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SRH2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005002907.1">
        <property type="protein sequence ID" value="ENSCJPP00005001722.1"/>
        <property type="gene ID" value="ENSCJPG00005001765.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00730000111107"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome LGE22C19W28_E50C23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903259">
        <property type="term" value="P:exon-exon junction complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039333">
        <property type="entry name" value="PYM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015362">
        <property type="entry name" value="WIBG_mago-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036348">
        <property type="entry name" value="WIBG_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22959:SF0">
        <property type="entry name" value="PARTNER OF Y14 AND MAGO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22959">
        <property type="entry name" value="PYM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09282">
        <property type="entry name" value="Mago-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01273">
        <property type="entry name" value="Mago-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101931">
        <property type="entry name" value="Pym (Within the bgcn gene intron protein, WIBG), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="279"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="WIBG Mago-binding" evidence="5">
        <location>
            <begin position="388"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="434"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="442"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="464"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="476"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005001722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="584" mass="64171" checksum="11A6D42B01CE1CC2" modified="2022-01-19" version="1">MGLDLLPLFPMGSDLLLIFPMGSDLLPMSPMGSDFPIGSDLLPLFPMGSDLLPLFPMGSDFPMGSDLLPIFPMGSDLLPIFLMGSDLLPLFPMGSDLLPMSPMGSDLLPIFPMGSDFLMGSNLLPMSPFGSGQLPLFPMGSDFPVGSDLLPMFPMWSDLLSVFPMGSDLFPMSPMGSDLLPIFPMGSHLLPLSPMGSDLLPMFPMGSDFPIGSDLLPLFPMGSDFLMGSDLLPMSPMGSDLLPMFPMGSGQISFLCFLWGQICFLWDQISFLCFLWDQIFLWGQISLLCLLWGLTSFLCFLWGHISTLHSLLAEISLYTHSLWGWINPPHSLYGLTSPTPMFNTGQAHHSPSFFYPIEGYQVPGTPSRVQGRDTPFPPPPSNVVSPPIGKYIASTQRPDGTWRKQRRVKEGYVPQEEVPVYENKYVKFFKSKPELPPGLSLEANTQPSKQPSKAEGGETGLSKTAKRNLKRKEKRKQQQEKGEKETDGLIQSLEKVSLSGGSSGDTGGAAPQPTCGTQSNADGEAAASEKSKKIKNLKKKLRQVEELQQRLDSGEIKQPTKEQLEKLGRRKALEEELHELELDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SRY4</accession>
    <name>A0A8C2SRY4_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BRD4 interacting chromatin remodeling complex associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BICRA</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="Ensembl" id="ENSCJPT00005005318.1">
        <property type="protein sequence ID" value="ENSCJPP00005002900.1"/>
        <property type="gene ID" value="ENSCJPG00005003184.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159112"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016514">
        <property type="term" value="C:SWI/SNF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140537">
        <property type="term" value="F:transcription regulator activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052438">
        <property type="entry name" value="Chromatin_remod/trans_coact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015671">
        <property type="entry name" value="GSCR1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15572:SF1">
        <property type="entry name" value="BRD4-INTERACTING CHROMATIN-REMODELING COMPLEX-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15572">
        <property type="entry name" value="GLIOMA TUMOR SUPPRESSOR CANDIDATE REGION GENE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15249">
        <property type="entry name" value="GLTSCR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GLTSCR protein conserved" evidence="2">
        <location>
            <begin position="1061"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="609"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="718"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="890"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1167"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1224"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1439"/>
            <end position="1550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="611"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="628"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="664"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="675"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="718"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="746"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="812"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="890"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="901"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="932"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1172"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1474"/>
            <end position="1512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1513"/>
            <end position="1527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005002900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1550" mass="161312" checksum="9F7AAA54A85DCE62" modified="2022-01-19" version="1">MDDEDGRCLLDVICDPQALNDFLHGSEKIDSDDLLDSTGDAASAFFEGAGLHVQESSGTHLTAEQSQPSASVDLDFLEDDILGSPAGGGAALPSSEQPCDILQQSLQEANITEQTLEAEAELDLGSFQLPTLQPVVQAASDAAPQIFSGGADLIGLQPPAVLTHQALVQQSVGADVVNKAISVQPFLQQVGLGNVTIQPISNLQSLPNGSPGGALGIGPIQVVGQQVMAINQPAQQLIAKQVQPSQVATVPVGSYITQPAPEQQQVTLTSAGVSPQGAGLVIQKNLPAVATTTLNGSSVFGGVSGAQGSQPLTVTSNLSSPLVQAQNVIIHRTPTPIQPKPAGVLQQKLYQISPKPFGSNNATLTIQNEAALQQQKAQQNLTFMAGKPAQNVVLSGFPQGLPANVFKQPPPQQQALSKPMSVHLLNQGGSIVIPAQHMLQGQNQFLLPGQLAGASAVQIPQQLSALPANVGGQILTASHGGGQAHIITSQGPGGQLIANQALPAQILTNQNLAGQLNLGQVLTSQNAHGTAHILSAPIQLQPGQVGQPALFQMPVSLAGGLTTQSQPSAAASLPGAAISQTGQTVIQGVTLPSQVAMLNAADGLGQAVSIQPSGSSQSPGLLPPQPAPAAGLLPSTTDPPASILAIQPSSAPPAAPAPLQLSVQPPPAAPPAAPLPAASQPSPGLASSPEKIILGQTAAGAVINQDSMQMFLQQLPAGQQQLPGASPSPSLPHPPLGESPQLPAAHLPPPPSPHPSRPPSQPQPLSRPPSRPHSRPPSQPRAPSEPPARSCTPQAPGIFGVPGQLSASPHIPLRPPSRPPPAPSPDPHSPHFQLQFPPQGPPTPALHLTAEQQRSFQMVPGQFQPLSAIPNPAPQQKQIVDRFQQVPQGIILQTKQQTPTSQASPALSQFSSQPSSVLVSSQGQPVTVTATPSPAHSHAPSAGPPSSAGGSAPPPSDSKPFSSAAAPIAAGKGPTATGKPGASLAMSQPVQTKPGVISSVSSLNLGKGPLQIQVVGKGLSQLVPSVQSQQLYDSKLGSLKKTPTLQPSKEACFLEQLHKHQGAVLHPDYKSSFHSFEDALQRLLPYHVYQGMLPSAQDYRKVDEEFEVVSTQLLKRTQAMLNKYRLLLLEESRRVSPSAEMVMIDRMFIQEEKTMLALDKQLAKEKPDEYVSSSSRSQSLSSAAAQPSSSSSSSGLAPAADSSKAPTVQTATAINPTKLVIKHSGGSPSVTWAKASPNLDGDDDALPSRSKPPIKTYEARSRIGLKLKIKQEAGLSKVVHNTALDPVHQTPPVCRVIKAAEQHSAAAGQMNGTVEHGSTAPAEKKAAVTFCRLPLRKTYRENVDAFVAEKPTEKGAAKADKGLLKQEDGTRGVITAHKTHESAERGRADDGSKLLFFGRSDARSLVLHGSPVPQKSDDSTSGLMKELAEVEEEFYHGMIKSEPPDHGPGPELSWEVPLPPAKRRKSESFEVDNASFSSDSPQDDSLNEHLQSAIDSILNLQQPQTGGQNVRTPSSSYNSSSSPFSSPVHRTDAYLAPNHNGGLGARTLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SS89</accession>
    <name>A0A8C2SS89_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Radixin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">RDX</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SS89"/>
    <dbReference type="Ensembl" id="ENSCJPT00005002896.1">
        <property type="protein sequence ID" value="ENSCJPP00005001712.1"/>
        <property type="gene ID" value="ENSCJPG00005001749.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01090000260082"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030175">
        <property type="term" value="C:filopodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005902">
        <property type="term" value="C:microvillus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001726">
        <property type="term" value="C:ruffle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120044">
        <property type="term" value="C:stereocilium base"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
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                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>IDENTIFICATION</scope>
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    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031885">
        <property type="entry name" value="DUF4764"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039946">
        <property type="entry name" value="ZN839"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16116">
        <property type="entry name" value="ZINC FINGER PROTEIN 839"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16116:SF5">
        <property type="entry name" value="ZINC FINGER PROTEIN 839"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15961">
        <property type="entry name" value="DUF4764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="205"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="75"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="306"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="82"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="132"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="306"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="326"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="342"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="354"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005002503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="880" mass="96366" checksum="06D998E090106112" modified="2022-01-19" version="1">MKETERPVPPSAPIQPKTVMLSQSVGRNSSVPGLGIINPQIIKIQPVTGPERQQQFLLHNSSESPVQLLMQKPLPSHGSVPVNKTPTSKVLNGQKTTRATASPARSSNIAASSTNTLMPCLDKKQKGDKLKRSLKVKTRSGRISRPPKYKAKDYKFIKMEDLADGHQSDSDDYSELSVEDDEEGKVKGKDALFNCSNYNLKPKMFKCQTCEKSYIGKGGLARHYKLNPGHGQMESVPQKTPLNKPNGSMFVDSLCGIGEEIMSPVHLNSIAVTLNNEDALPANVEETAGSQVEQTCESAESRNLLVEQQNESSSGQRGPITAKGPGRPRRTKSRGRPRMGGRSRCSGRLSRPGQSPSKSLSSVSTERSVFRRKARLKELIQQCGNEDLMELALPRLTELVTVYEFLLMKVEKGCPAKASFPDVYREFEELHNMVKKMAYDYLSNSDFLSCQQHIEIKDAKVAESLGIPEITAGQQKMRGVDSCSQHIIKMVSEQVPVETLGRKRLAESSGEELLPSAKRTKLEDVMENVNNAYSSQDEVKEKSGNLCTLFEKDGLNPLNREILLSEDRRVTCCTAGSMLPAEEECNLFVDSEVRIDAENSGTFSQTVELRIEYSQPVDRQGPGISADTSLLHTEIVLPVEAGSSPELAEAHLVSQNTAGGLSAPEPCNSESEHAVGIQSTDLAMSEENGLNQKCQTPQEENQNFAMKGQSGQFHDAGVAEMQEMEKAFSIHVPINHPHGAQAELHQNAVQESSLSAGVNHDCAYNNVNEFSCGTEEQHELENTVTDQTVAFEITDESHDFFTQGHEQIFIQTSDGLILSHPDAAVLSQAEGIVIVTDSDGTTMHIRTPDGIPLETVEALLAMEADGQSEDVLLSQSELEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2STH3</accession>
    <name>A0A8C2STH3_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2STH3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005004442.1">
        <property type="protein sequence ID" value="ENSCJPP00005002424.1"/>
        <property type="gene ID" value="ENSCJPG00005002661.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01050000244936"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019814">
        <property type="term" value="C:immunoglobulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:002198">
        <property type="entry name" value="Immunoglobulin heavy variable 5-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050199">
        <property type="entry name" value="IgHV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23266">
        <property type="entry name" value="IMMUNOGLOBULIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="1" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-1280">Immunoglobulin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005002424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="117" mass="12758" checksum="E38D62F289054B81" modified="2022-01-19" version="1">DMDLQTTIGGLSLVCKASGFTISDYTMFWVRQAPGKGLEWVAGISYTGGSKYYAPAVKGHATITRDNGQSTVRLQLNSLKDEDSAMYYCARGYSSGCNYEAYAIDVVVVLIMVMMLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SU16</accession>
    <name>A0A8C2SU16_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">OXA1L mitochondrial inner membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">OXA1L</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the OXA1/ALB3/YidC family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SU16"/>
    <dbReference type="Ensembl" id="ENSCJPT00005005814.1">
        <property type="protein sequence ID" value="ENSCJPP00005003243.1"/>
        <property type="gene ID" value="ENSCJPG00005003469.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063506"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032979">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane from matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20069">
        <property type="entry name" value="5TM_Oxa1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.150.10.10">
        <property type="entry name" value="Serralysin-like metalloprotease, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011049">
        <property type="entry name" value="Serralysin-like_metalloprot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028055">
        <property type="entry name" value="YidC/Oxa/ALB_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03592">
        <property type="entry name" value="yidC_oxa1_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428:SF66">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEIN OXA1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="OXA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02096">
        <property type="entry name" value="60KD_IMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Membrane insertase YidC/Oxa/ALB C-terminal" evidence="12">
        <location>
            <begin position="125"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="369"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="375"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005003243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="396" mass="42840" checksum="E6B3E7323B557604" modified="2022-01-19" version="1">MQATAATPMSPMEQQGPLMGQESTLMGQESTLMGQKTPLMGQEAPLMGQGTPLMGQEAPLMGQKNSLMGQESTLMGQEGAVMGQPHGCVGLAEARLEDLGLGSLTPVGLIQNLLQFLHLDVGLPWWGAIAAGTLCVRVALLPLLLKAQREAARTAPHLPHIQRLAQRLQDAKRGADPQQAPYNRSCWRIKQKHNVNPLRGFLVPIVQTPIFISFFLALQQMAALPVPGFQHGGAGWINDLSCPDPTYALPLLSSATMWMVLEAGVESGVSSPQAGAVRVVLRLLPLLFLPMTIHFPAAIFVYWLTSNSFSLLQALLLRVPVVRSALRIPALPHNPPMEPNGAGPKEGILQRMRNSERLWGIWGGPLRQTFAQNPLAPPVAPEPPPAPKRPWKETLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SUC0</accession>
    <name>A0A8C2SUC0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mediator of RNA polymerase II transcription subunit 17</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mediator complex subunit 17</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">MED17</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6 7">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the Mediator complex subunit 17 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015707794.1">
        <property type="nucleotide sequence ID" value="XM_015852308.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SUC0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005006720.1">
        <property type="protein sequence ID" value="ENSCJPP00005003884.1"/>
        <property type="gene ID" value="ENSCJPG00005003976.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107308435"/>
    <dbReference type="KEGG" id="cjo:107308435"/>
    <dbReference type="CTD" id="9440"/>
    <dbReference type="GeneTree" id="ENSGT00390000011810"/>
    <dbReference type="OrthoDB" id="10058398at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046966">
        <property type="term" value="F:nuclear thyroid hormone receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060261">
        <property type="term" value="P:positive regulation of transcription initiation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035019">
        <property type="term" value="P:somatic stem cell population maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019313">
        <property type="entry name" value="Mediator_Med17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13114">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13114:SF7">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10156">
        <property type="entry name" value="Med17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005003884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="643" mass="72275" checksum="E9141C20A11BA68B" modified="2022-01-19" version="1">MAGVPAVRISIESACEKQVQEVGLDGSETYLQPLSMSQNLARLAQRIDFSQGSGSEEDEPGSAGRAWAEQNEAEDEEGLVKFQPSLWPWDSVRNNLRSALTEMCVLYDVLSIVKDKKFMTLDPVVQDPPPPKQNPQFLQLISKKKSLAGAAQILLKGAERLSKSVAENQENKRQRDFNSELLRLRQHWKLRKVGDKILGDLSYRSAGSLFLHHGTFEVIKNTDIDLDKKIPEDYCPLDVQIPSDLEGSAYIKVSIQKQAPDIGDLGTVNLFKRPMPKSKPGTPHWQTKLETAQNVLLCKEIFAQLSREAVQIKSQIPHIVVKNQIISQPFPGLQLSISLCHSSNDKKSQKSTSEKQNPEDHLYVLEHNLHQLIRECHKQTLSSTVMPHPASAPFGHKRMRLAGPQAFDKNEITALQTNEGLLEKIIKQAKHIFLRRRTARTIDSLASRIEDPQIQAHWSNINDVYESSVKVLITSQGYEQICKSIQLQLNIGVEQIRVVHRDGRVITLSHQEQELQDFLLSQMSQHQVHAVQQLAKVMGWHVLSFSNHVGLGPVESIGNASAITVASPNGDYAISVRNGPESGSKVMVQFPRSQCKDLPKGDVLQDNKWNHLRGPFKEVQWNKMEGRNFVYKMELLMAALTPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SUJ5</accession>
    <name>A0A8C2SUJ5_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TNFAIP3 interacting protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TNIP3</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SUJ5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005006150.1">
        <property type="protein sequence ID" value="ENSCJPP00005003483.1"/>
        <property type="gene ID" value="ENSCJPG00005003643.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00510000046908"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071222">
        <property type="term" value="P:cellular response to lipopolysaccharide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002756">
        <property type="term" value="P:MyD88-independent toll-like receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043124">
        <property type="term" value="P:negative regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034142">
        <property type="term" value="P:toll-like receptor 4 signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.990:FF:000004">
        <property type="entry name" value="TNFAIP3 interacting protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.990">
        <property type="entry name" value="Nemo cc2-lz domain - 1d5 darpin complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032419">
        <property type="entry name" value="CC2-LZ_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31882:SF2">
        <property type="entry name" value="TNFAIP3-INTERACTING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31882">
        <property type="entry name" value="TNFAIP3-INTERACTING PROTEIN COILED COIL FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16516">
        <property type="entry name" value="CC2-LZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034116166" evidence="4">
        <location>
            <begin position="18"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="NF-kappa-B essential modulator NEMO CC2-LZ" evidence="5">
        <location>
            <begin position="258"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="418"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="155"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="240"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="305"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="445"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005003483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="460" mass="53695" checksum="A7B5C98671F288C2" modified="2022-01-19" version="1">MFHFVLELFCNLGITKGGDFAWSGCDRSSVVQGVQISEKIHCEKFKRKSEEAEDLLELHSHQHVEMERCESKELDVEIRNLIERSGTSKSCEDPEPIAQGSLNHQRTLCSLKTCSEVNAQGHLESAWADVSEMEAPADPLESKHVLPNKQKTVLANSQERLILSLERQRQELLEVNKQWDHQFRTMKQLYEKQLAEVKAKLRVSERKVCKLEEERHRHPPEMERLQVLDRDRPSQEAEEIKVLSEALHEMKEENKLLKQKNVSMIRKQEHYECEISRLNKALLDVLKKNSSILRTPSETGDKNSLDDMRTQLEVLKQQVQIYEEDFRKERSDRERLNEEKEALQRANERLQAQLNKLNSKMKTCLKGKEQERQLLQQTKDILVRSERLTYPPPLFLSPCANYGSCGLVLHYQDPQVHPVSRRAQEQQQHSPDYQWYVPDQFPPDVQHKANDSSSEKGAHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SUX4</accession>
    <name>A0A8C2SUX4_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Sodium/mannose cotransporter SLC5A10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Sodium/glucose cotransporter 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Solute carrier family 5 member 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">SLC5A10</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Electrogenic Na+-coupled sugar symporter that actively transports D-mannose or D-fructose at the plasma membrane, with a Na+ to sugar coupling ratio of 1:1. Transporter activity is driven by a transmembrane Na+ electrochemical gradient set by the Na+/K+ pump. Exclusively recognizes sugar substrates having a pyranose ring with an axial hydroxyl group on carbon 2. Has likely evolved to enable renal reabsorption of D-mannose, an important constituent of oligosaccharide chains of glycoproteins. Contributes to dietary D-fructose reabsorption from glomerular filtrate across the brush border of the kidney.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>D-fructopyranose(out) + Na(+)(out) = D-fructopyranose(in) + Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:72915"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:37714"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:72916"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>D-mannose(out) + Na(+)(out) = D-mannose(in) + Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:72907"/>
            <dbReference type="ChEBI" id="CHEBI:4208"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:72908"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 19">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SUX4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005007089.1">
        <property type="protein sequence ID" value="ENSCJPP00005004181.1"/>
        <property type="gene ID" value="ENSCJPG00005003842.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159416"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005412">
        <property type="term" value="F:D-glucose:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140930">
        <property type="term" value="F:fructose:sodium symporter activity"/>
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        <property type="entry name" value="SODIUM_MANNOSE COTRANSPORTER SLC5A10"/>
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    </dbReference>
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        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
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            <dbReference type="Proteomes" id="UP000694412"/>
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    </evidence>
    <sequence length="649" mass="69936" checksum="A1234630C5396B34" modified="2022-01-19" version="1">GEAGSRGRMEGNSTAGSFSPSQQFSVADLVVIVTYFSLNLAVGIWSSCRVNRNTVSGYFLAGRDMAWWPIGASLFASSEGSGLFIGLAGTGAAGGIAVTGFEWNATYALLALAWVFVPVYISSGIVTMPEYLQRRFGGERIRMYLSGLSLLLSIFTKISTDLYSGALFVQVCLGWDLYLSTVLMLLVTGLYTIAGGLAAVIYTDALQTVIMVLGAIMLAVRAFDAIGGYSNLEEAYLKAVPSKIVPNTTCHLPRADAMHLFRDPISGDLPWTGMTFGLSIMATWYWCTDQVIVQRSLSARNLSHAKAGSILASYLKMLPLFVIIMPGMISRVLFPDAVACVDPEECTHVCGAAVGCSNIAYPKLVVELMPSGLRGLMIAVMMAALMSSLTSIFNSCSTLFTMDIWRRMRPGASERELLLVGRVMTVLLVALSVVWIPILQSSSGGQLYIYIQAVTSYLAPPVTAVFILAVFWPRANEQGAFWGLMAGLALGLARMGLELAHPTPHCGVPDRRPWLLADLHYLHFAALLCATTGAVVVGGSLMTPPPPSERVSRTRRHPGTSQGYPQLFTCMHHPCSMDALCLSFPLVSCPYNHCLSVPGSCPAASGSQQTTEGLPALRDTTESPFWTRVCSINAIVLLCINIFCYAYFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SV10</accession>
    <name>A0A8C2SV10_COTJA</name>
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        <recommendedName>
            <fullName evidence="5">NlpC/P60 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
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            <taxon>Eukaryota</taxon>
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            <taxon>Vertebrata</taxon>
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            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034444633" description="NlpC/P60 domain-containing protein" evidence="2">
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            <begin position="26"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005003486.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="101" mass="10869" checksum="ACEB8B97A5D68432" modified="2022-01-19" version="1">MWLCPQAVAGAASTAAFFLCEGLLGQHFDMVPNGVAEPQPGDLFLFPLASGGPGWWGAHAGVYCGDGEIIHLEGEQWEETPHRGHEAKQLMFGDHNTPWAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SW03</accession>
    <name>A0A8C2SW03_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Mitogen-activated protein kinase kinase kinase 4</fullName>
            <ecNumber evidence="4">2.7.11.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">MAPK/ERK kinase kinase 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">MAP3K4</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Component of a protein kinase signal transduction cascade. Activates the CSBP2, P38 and JNK MAPK pathways, but not the ERK pathway. Specifically phosphorylates and activates MAP2K4 and MAP2K6.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Perinuclear region</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.25" evidence="4"/>
    <dbReference type="RefSeq" id="XP_032299838.1">
        <property type="nucleotide sequence ID" value="XM_032443947.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005007493.1">
        <property type="protein sequence ID" value="ENSCJPP00005004478.1"/>
        <property type="gene ID" value="ENSCJPG00005004431.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107311515"/>
    <dbReference type="CTD" id="4216"/>
    <dbReference type="GeneTree" id="ENSGT00880000138034"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019100">
        <property type="term" value="P:male germ-line sex determination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900745">
        <property type="term" value="P:positive regulation of p38MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032206">
        <property type="term" value="P:positive regulation of telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010225">
        <property type="term" value="P:response to UV-C"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd06626">
        <property type="entry name" value="STKc_MEKK4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000122">
        <property type="entry name" value="Mitogen-activated protein kinase kinase kinase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045801">
        <property type="entry name" value="MEKK4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF32">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19431">
        <property type="entry name" value="MEKK4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="21">
        <location>
            <begin position="1306"/>
            <end position="1564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="400"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1119"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1166"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1207"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="20">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="432"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="1174"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="1215"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="1335"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00060115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00069057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00083883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005004478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1571" mass="177587" checksum="C1D879A0EFA514FA" modified="2022-01-19" version="1">MRRVAAPLPAAAAMEEPPPPPGRKECKSEDATCKISESEAEELSDEASADTFYGTSPPSTPRQMKRMSTKHQKNNVGRPASRSTLKEKMSIPPQSVHKDNGKTIENVEEHSYKQGKKIRATLRTTERDHKKNVQCSFMLDSVGGSLPKKTIPDVDLNKPYLSLGCSNAKLPVSVPMPISRTARQTSRTDCPADRLKFFETLRLLLKLTSVSKKKDREQRGQESTSSVWLNRSNELIWLELQAWHAGRSINDQDLYLYAARQAIPDIINEILTFKVNYGSFSYVKNGASLNGTSGEGVCKATHGTSALGYSSYHEHLHRQRISFEQVKRIMELLEYIEALYPSLQALQKDYEKYAAKDFQDRVQALCLWLNITKDLNQKLRIMGTVLGIKNLSDIGWPVFEIPSPRPSKDDDPEDEGVDRETEVKESSGTCTEESDGEEQISEENVEELRQAIKNNFTNQPNFDFQDHFSRKLDRLESGDDSASWIIPECSAEAGCSKHCLTSIYRPFVDKALKQMGLRKLILRLHKLMHGSLQRARMALVRSDCPLEFSDCPDPMLCSDYVQLLNSPPCCEQKCSTVSWEELKSMDLPSFEPAFLVLCRVLLNVIHECLKLRLEQRPAGEPSLLSIKQLVRECKEVLKGGLLMKQYYQFMLREVLDDLQKIDCNIDAFEEDLHKMLMVYFDYMRSWIQMLQQLPQASHSLKNLLEEEWNFTKEITPYIRGGEAQAGKLFCDIAGMLLKSTGIFLDSGLQDSCDEFWASADDSTASDEIRRSVIETSRALKELFHEARERASKALGFAKMLRKDLEIAAEFALSAPVGDLLNALKTKEYVKVQIPGLENLQVFVPNSIAGEKAVILQLLNAAAGKDCSKDSDEVAYEAYLIMTKHSDKDHELCDMWSAWEGQPVKVVPQVETVDTLRSMQVDNLLLVVIQSAHLVSQRKAFQQSIEGLISLHQEQTSSQPVIAKALQQLKNDALQLCNKISSAIDRVDHMFTSEFDAEVDESESATLQQYYREAMIQAYNFGFEYHKEVVRLMSGEFRQKIGDKYISFARKWMNYVLTKCESGRGTRPRWATQGFDFLQAIEPAFISALPEDDFLSLQALMNECIGHVIGKPHSPVTAIHRNSPRPVKVPRCHSDPPNPHLIIPTPEGFSTRSVPCDARNPCNVTVSRPAPIGSDSAQPKSVSSANDTRGSSVPENDRLASIAAELQFRSLSRHSSPTEEREEPSYPKGDSSGSSRRSWELRTLINQTKDTVSKQAPIEAVQKSVQLFEERRYREMRRKNIIGQVCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSKLGLQEHVIRLYTKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNTQTMPGEVNSTLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYRVGMGHKPPIPDKVSPEGKDFLCHCLESDPKMRWTASQLLDHPFVKVCTDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SXR1</accession>
    <name>A0A8C2SXR1_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Syntabulin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">SYBU</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015711598.1">
        <property type="nucleotide sequence ID" value="XM_015856112.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SXR1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005008773.1">
        <property type="protein sequence ID" value="ENSCJPP00005005391.1"/>
        <property type="gene ID" value="ENSCJPG00005005178.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107310437"/>
    <dbReference type="KEGG" id="cjo:107310437"/>
    <dbReference type="CTD" id="55638"/>
    <dbReference type="GeneTree" id="ENSGT00520000055634"/>
    <dbReference type="OrthoDB" id="5807119at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904115">
        <property type="term" value="C:axon cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031982">
        <property type="term" value="C:vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019896">
        <property type="term" value="P:axonal transport of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060074">
        <property type="term" value="P:synapse maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028197">
        <property type="entry name" value="Syntaphilin/Syntabulin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16208">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN/SYNTAPHILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16208:SF4">
        <property type="entry name" value="SYNTABULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15290">
        <property type="entry name" value="Syntaphilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="271"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="145"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="165"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="185"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="208"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005005391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="658" mass="72324" checksum="E91B5DAA4573F5A6" modified="2022-01-19" version="1">MGPLRESGKEEQKAHPEKEVSRSRIPRLVLRPQPPQQRKVSPASESPFSEEESREFNPPSSSGGSARTISSNSFCSDDTGCPSSQSVSPVKTPSDAGHSPISFCTGSDGDFSRKKFNAGTMSEGNSQLSRYKKETKTSLVKPGSEADFSSSSSTGSISAPEVHMSASGSKRSSFSRNRGPYGRNSGSSSYKSGASPPASHEKDHLSTLCRSQQNPVNIHQNYGVSSPSSSNSGSYKGSDTSPIMRRSGRYLTCVDHHSVKPQNPEQYLTPLQQKEVTVRHLKTKLKESQSKLKERETEIEELKAQLGRMREDWIEEECHRVEAQLALKEAKKEIKQLKQVIETMKNNLAEKDKGIQKYFIDINIQNKKLESLLHSMEMAQNGSLRDEDVSDTPGKPLALYARLPDTLITEEQALEVDSGVLLNEDIANGNDSFQETFSTACVESADPAFFISVMDQEVLESVPDEKLRSPRKEERSGIVMVEQSVQTDVVPYSLSVERLIQNIFGSQDVSPLSPPSSLKELSDFSSGSFSDSAIVVDLTPSDPNSAILLSPMESPCRKLDFGVDENHVMKELDFTETRDEVFGYVNTSSETGIMQRHWSGSLLVDVLAVAAPVVPTVLWAFSTQRGGVDPIYNIGALLRGCCLVALHSLRRTAFNIRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SYQ1</accession>
    <name>A0A8C2SYQ1_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">KIAA1328</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">KIAA1328</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SYQ1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005009313.1">
        <property type="protein sequence ID" value="ENSCJPP00005005810.1"/>
        <property type="gene ID" value="ENSCJPG00005005487.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000011152"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome Z"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032736">
        <property type="entry name" value="Hinderin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28375">
        <property type="entry name" value="PROTEIN HINDERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28375:SF1">
        <property type="entry name" value="PROTEIN HINDERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15369">
        <property type="entry name" value="KIAA1328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="428"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="75"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="338"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="451"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="471"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="489"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005005810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="527" mass="58248" checksum="7D438E03D8384ED9" modified="2022-01-19" version="1">RVYVSGLSTKGNLRTRCLPKCHKGETELEVPVAVSSVSMDPARSTGDLTGHQVTNEGGMKSASLKDLCPEDKRRIANLIKELARVSEEKEVTEERLKAEQESFEKKIRQLEEQNDEFFPLNFYVSPMQQQYRECQELLSLYQKYLAEQQEQLSHSLSQLSAAKETEQKVSGKKSFCQQPPSELDGSYLAVAGPQTLYKNSRASKAGSPSRVASSQPCRNNHNYGTEIIYNHQDCPKENPLDNGLHRKCNNMTSSVKERSPHHVKPAQEMDQKANEFPSTCPPQMIHGCACKHVESSGSIQKSHHVSQVPRRLSGPALKTCDYSRLSRVSGLNDSRGSGSKETEQAKKLSEERRQQLLLQKMELEIEKERLQNLLAKQEAKLLLKQQQLHHSQMDYSRFKGHVSGSGDVLTDGTPGELALMMNGNSMGLSVPVSKREDCDPRTPPVSKAPRSSRSSGGSSSGKKMSGFGANVEDRRALLVQAKREGSMSRKGTTSGPRGDATTSPALVSSSKELVTTATSPIQHDISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SYV3</accession>
    <name>A0A8C2SYV3_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Protein transport protein SEC23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">SEC23B</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasmic vesicle</location>
            <location evidence="13">COPII-coated vesicle membrane</location>
            <topology evidence="13">Peripheral membrane protein</topology>
            <orientation evidence="13">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 13">Endoplasmic reticulum membrane</location>
            <topology evidence="1 13">Peripheral membrane protein</topology>
            <orientation evidence="1 13">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
            <location evidence="13">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the SEC23/SEC24 family. SEC23 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015712503.1">
        <property type="nucleotide sequence ID" value="XM_015857017.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SYV3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005006926.1">
        <property type="protein sequence ID" value="ENSCJPP00005004048.1"/>
        <property type="gene ID" value="ENSCJPG00005004104.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107310919"/>
    <dbReference type="CTD" id="10483"/>
    <dbReference type="GeneTree" id="ENSGT00390000006916"/>
    <dbReference type="OrthoDB" id="10256289at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01478">
        <property type="entry name" value="Sec23-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11287">
        <property type="entry name" value="Sec23_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.730:FF:000003">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.380:FF:000001">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1670:FF:000006">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000003">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000011">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037364">
        <property type="entry name" value="Sec23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037550">
        <property type="entry name" value="Sec23_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141:SF10">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 13" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 13" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <keyword evidence="7 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="15">
        <location>
            <begin position="58"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="16">
        <location>
            <begin position="127"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="18">
        <location>
            <begin position="403"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="17">
        <location>
            <begin position="520"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="14">
        <location>
            <begin position="634"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005004048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="767" mass="86344" checksum="2627663DC511AF12" modified="2022-01-19" version="1">MATYLEFIQQNEERDGVRFSWNVWPSSRLEATRMVVPLACLLTPLRERPDLPPVQYEPVLCSRNTCKAVLNPLCQVDYRAKLWACNFCFQRNQFPPAYAGISEVNQPAELMPQFSTIEYIVQRGPQTPLIFLYVVDTCLEEEDLQALKESLQMSLSLLPADALVGLITFGRMIQVHELSCEGISKSYVFRGTKDLTAKQIQDMLGLSRPAVPIQQGRPLQAPEQPVISSRFLQPVHKIDMNLTDLLGELQRDPWPVTQGKRPLRSTGVALSIAVGLLEGTFPNTGARIMLFTGGPPTQGPGMVVGDELKTPIRSWHDIEKDNARFMKKATKHYETLANRTATNGHCIDIYACALDQTGLLEMKCCANLTGGHMVMGDSFNTSLFKQTFQRVFNKGLNGEFRMAFGANLEVKTSRELKIAGAIGPCVSLNVKGPCVSENELGIGGTSQWKICGLDPCTTLAIYFEVVNQHNAPIPQGGRGAVQFVTQYQHSSTQKRIRVTTIARNWADAQSQLQHIEAAFDQEAAAVLMARLGVYRAESEEGPDVLRWLDRQLIRLCQKFGQYNKDDPNSFRLSESFSLYPQFMFHLRRSPFLQVFNNSPDESSYYRHHFMRQDLTQSLIMVQPILYAYSFNGPPEPVLLDSSSILPDRILLMDTFFQIVIYLGETIAQWQKAGYQDMPEYENFKHLLQAPLDDAQEILQTRFPMPRYVHTEHGGSQARFLLSKVNPSQTHNNLYAWGQESGAPILTDDVSLQVFMDHLKKLAVSSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SYX8</accession>
    <name>A0A8C2SYX8_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Parkin coregulated</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">PACRG</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SYX8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005007433.1">
        <property type="protein sequence ID" value="ENSCJPP00005004440.1"/>
        <property type="gene ID" value="ENSCJPG00005004398.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157330"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160112">
        <property type="term" value="C:axonemal B tubule inner sheath"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044297">
        <property type="term" value="C:cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097386">
        <property type="term" value="C:glial cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002177">
        <property type="term" value="C:manchette"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097225">
        <property type="term" value="C:sperm midpiece"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031982">
        <property type="term" value="C:vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043014">
        <property type="term" value="F:alpha-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030317">
        <property type="term" value="P:flagellated sperm motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007286">
        <property type="term" value="P:spermatid development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019399">
        <property type="entry name" value="Parkin_co-regulated_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21207:SF2">
        <property type="entry name" value="PARKIN COREGULATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21207">
        <property type="entry name" value="PARKIN COREGULATED GENE PROTEIN PARK2 COREGULATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10274">
        <property type="entry name" value="ParcG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005004440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="254" mass="28865" checksum="C2F7A9AD82D1E74D" modified="2022-01-19" version="1">MVEEEAGGGPAKPGGNRLSQKQEPLGHVKKSKPQVSDGFTVKAMMKNTVVRGPPVAGAFKERPRKPTAFRRFYERGDFPIALDHDTKGNRIAWKVEIEKLDYHYYLPLFFDGLCEMTFPCEFFARQGIHDMLEHGGNKILPVIPQLIIPIKNALSLRNRQVLCITLKVLQHLVLSADMVGEALVPYYRQLLPIFNIFKNMNVNSGDGIDYSQQKRENIGDLIQETLEIFERHGGESAYINIKYMIPTYQSCILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T079</accession>
    <name>A0A8C2T079_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amine oxidase</fullName>
            <ecNumber evidence="8">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC107325299</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="8">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <text evidence="7">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="PTM">
        <text evidence="7 8">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="8"/>
    <dbReference type="RefSeq" id="XP_015741496.1">
        <property type="nucleotide sequence ID" value="XM_015886010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T079"/>
    <dbReference type="Ensembl" id="ENSCJPT00005009120.1">
        <property type="protein sequence ID" value="ENSCJPP00005005655.1"/>
        <property type="gene ID" value="ENSCJPG00005005371.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107325299"/>
    <dbReference type="KEGG" id="cjo:107325299"/>
    <dbReference type="GeneTree" id="ENSGT00950000183207"/>
    <dbReference type="OrthoDB" id="5379943at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.20:FF:000015">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.40:FF:000001">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.40:FF:000007">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049947">
        <property type="entry name" value="Cu_Am_Ox_Cu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049948">
        <property type="entry name" value="Cu_Am_ox_TPQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015800">
        <property type="entry name" value="Cu_amine_oxidase_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015802">
        <property type="entry name" value="Cu_amine_oxidase_N3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF4">
        <property type="entry name" value="RETINA-SPECIFIC COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02727">
        <property type="entry name" value="Cu_amine_oxidN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02728">
        <property type="entry name" value="Cu_amine_oxidN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00766">
        <property type="entry name" value="CUDAOXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01164">
        <property type="entry name" value="COPPER_AMINE_OXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01165">
        <property type="entry name" value="COPPER_AMINE_OXID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0186">Copper</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6 8" id="KW-0801">TPQ</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034418391" description="Amine oxidase" evidence="9">
        <location>
            <begin position="20"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase N2-terminal" evidence="11">
        <location>
            <begin position="73"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase N3-terminal" evidence="12">
        <location>
            <begin position="161"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="10">
        <location>
            <begin position="303"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="374"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via topaquinone" evidence="6">
        <location>
            <position position="459"/>
        </location>
    </feature>
    <feature type="modified residue" description="2',4',5'-topaquinone" evidence="7">
        <location>
            <position position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005005655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="754" mass="84652" checksum="A8DE32EBF1A5018F" modified="2022-01-19" version="1">MNMKTALMLLLLALATIFALVCVLLTRARAPGACQQQPPAQEEDDGHSRVFADLSPEELAQVVQYLRGSLGVPLVDAARAKPSDNCIASVDVQLPAKAEVLRFLDDGGTRPPREALAVLYFGAQAEPNVTEYVVGPLPAPTYHRDVTVQKYGGKVPYHRRPALPAEYKQIADFFKKQVFPAAPSFMEQVMEYDGTSLATVTAAPRGSRSGDRLTWFVMFQNVSGFFLHPVGLEVLVDHSSLDLTQWAVRRVFYNGQYYGDMSELERIYVQGGVRVEKVRKAPRDGDFSSMRPRAPVAATFPLQYEPQGPRYIIRSNLVIFQAWSFAFGMSVTTGLRLFDIRYNGERVVYELSVQEALSVYGSNCPGGMSTRYMDGSFGIGRYASPLVRGVDCPYMATYVDTHTLHEGLSSSKRTVALCIFEQNLGSPLRRHYSNLQSLYYGGMVNSALVLRSITTVGNYDYVWDFIFYQNGAIEGKVQATGYTSSSFFHGNGLQYGNRVWEHTLGTIHTHFVNYKVDLDVGEVKNSLVAHDMAFEMVQAPWNPEQQIERPRLTKKVLDTEDQAAFRLHSPMPRYIYFATNQKNKWGHQRGYRIQIISFAGDHIPEASSMERAISWARYKLAVTRRKEEEPTSTSVYNQNDPWTPTVAFADFINNETITNEDLVAWITAGFLHIPHSEDIPNTLTVGNSVGFLLRPYNYYDLDPSIYSPDGVFFTSEQNFMVCEVNPITCLSQTASCLPSLPPFTYDGFQNSSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T0N5</accession>
    <name>A0A8C2T0N5_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T0N5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005009371.1">
        <property type="protein sequence ID" value="ENSCJPP00005005860.1"/>
        <property type="gene ID" value="ENSCJPG00005005544.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000175728"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053234">
        <property type="entry name" value="RPM1_Interactor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33443:SF30">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-2C PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33443">
        <property type="entry name" value="ZGC:112980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005005860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="256" mass="28888" checksum="E1E6766D79D9ADA7" modified="2022-01-19" version="1">MEPSKGKRERDVILISDDEDEGTHGNSVLIVDPLAKTALEEKKCEEVVDEECELVVTFCKQANVMPHARYDCTINSFERMECETCSPTGKNADFCNQCYCYICDKLASECQNWTTSSLCHCNAHNKSKFWKDQRDFALAGVLVMFNLELTDIDADLRHGGNLLIRFIQELSVEYNKYLIGERVSPTEHKCLCVSKLPPGQCDICRSQNTKIVYKYSGVFALVTRFLNQAERESPKAAAVMLLGAAREITLHKDPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T1Y4</accession>
    <name>A0A8C2T1Y4_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">26S proteasome non-ATPase regulatory subunit 8-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC107307294</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T1Y4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005009871.1">
        <property type="protein sequence ID" value="ENSCJPP00005006243.1"/>
        <property type="gene ID" value="ENSCJPG00005005868.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000014682"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006746">
        <property type="entry name" value="26S_Psome_Rpn12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033464">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12387">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12387:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10075">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0647">Proteasome</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSN8/PSMD8/EIF3K" evidence="2">
        <location>
            <begin position="117"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="188" mass="20634" checksum="FAB131E465FA2CAE" modified="2022-01-19" version="1">APCRTHGDGGPVLTGGCAGAAGAAGMYEQLKGEWGPGRARNLNKCGEALGRLRLALLDLNFLPTGGTELTKQQLVLAKIGAQWSILKKDIPSFERYMAQLKCYYFDYKDELPDSAFRHQLLGLNLLFLLSQNRVAEFHTELERLPARDIQTNVYIRHPVSLEQVRGEGLPDFRFVGTSGVSMCGGLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T2T6</accession>
    <name>A0A8C2T2T6_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">P2Y purinoceptor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">P2RY2</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015708154.1">
        <property type="nucleotide sequence ID" value="XM_015852668.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015708155.1">
        <property type="nucleotide sequence ID" value="XM_015852669.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T2T6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005010467.1">
        <property type="protein sequence ID" value="ENSCJPP00005006676.1"/>
        <property type="gene ID" value="ENSCJPG00005006201.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107308646"/>
    <dbReference type="KEGG" id="cjo:107308646"/>
    <dbReference type="CTD" id="5029"/>
    <dbReference type="GeneTree" id="ENSGT01030000234621"/>
    <dbReference type="OrthoDB" id="10018446at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031686">
        <property type="term" value="F:A1 adenosine receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045028">
        <property type="term" value="F:G protein-coupled purinergic nucleotide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045030">
        <property type="term" value="F:G protein-coupled UTP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097746">
        <property type="term" value="P:blood vessel diameter maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007200">
        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070257">
        <property type="term" value="P:positive regulation of mucus secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15373">
        <property type="entry name" value="7tmA_P2Y2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000017">
        <property type="entry name" value="lysophosphatidic acid receptor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000356">
        <property type="entry name" value="P2Y2_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24231:SF17">
        <property type="entry name" value="P2Y PURINOCEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24231">
        <property type="entry name" value="PURINOCEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00594">
        <property type="entry name" value="P2Y2PRNOCPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01157">
        <property type="entry name" value="P2YPURNOCPTR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="201"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="55"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="336"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="358" mass="40816" checksum="597EE5646C3225F5" modified="2022-01-19" version="1">MANLSTPPAWTRVINSSFVTGNADNNTYRCVFDEDFKYVLLPVSYGIVCVVGLFLNLLALYGFIFRIKTWNASTTYMFNLAISDTLYVVSLPLLVYYYAMGDNWPFGVGLCKIVRFLFYTNLYCSILFLLCISIHRFLGICYPLKSLQWGHVRYARRVSVIVWVVTVVCQLPVLFFVTTSMRRGTITCHDTSSKDLFGQFVIYSSVMMVLLFCIPFLIIIVCYCLMARRLLQPTRGMSRLSRSKKKSVKMIIIVLVVFSVCFLPFHVTRSLYYSFRSWDLSCQTLNAINLAYKVTRPLASTNSCLDPVLYFLAGQRFMKLTGNKIPWKPQNEMAMGTVPNGPLGTSDDTDTTSKDMKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T2T8</accession>
    <name>A0A8C2T2T8_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">General transcription factor 3C polypeptide 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">TF3C-epsilon</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Transcription factor IIIC 63 kDa subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Transcription factor IIIC subunit epsilon</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">GTF3C5</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the TFIIIC subcomplex TFIIIC2, consisting of six subunits, GTF3C1, GTF3C2, GTF3C3, GTF3C4, GTF3C5 and GTF3C6. Interacts with BRF1, GTF3C6 and TBP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TFIIIC subunit 5 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T2T8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005011530.1">
        <property type="protein sequence ID" value="ENSCJPP00005007436.1"/>
        <property type="gene ID" value="ENSCJPG00005006845.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000004458"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000995">
        <property type="term" value="F:RNA polymerase III general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001002">
        <property type="term" value="F:RNA polymerase III type 1 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001003">
        <property type="term" value="F:RNA polymerase III type 2 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035914">
        <property type="term" value="P:skeletal muscle cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.160:FF:000001">
        <property type="entry name" value="General transcription factor IIIC subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.160">
        <property type="entry name" value="TFIIIC, subcomplex tauA, subunit Sfc1, barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019136">
        <property type="entry name" value="TF_IIIC_su-5_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040454">
        <property type="entry name" value="TF_IIIC_Tfc1/Sfc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041499">
        <property type="entry name" value="Tfc1/Sfc1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042536">
        <property type="entry name" value="TFIIIC_tauA_Sfc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13230:SF5">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13230">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIIC, POLYPEPTIDE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09734">
        <property type="entry name" value="Tau95"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17682">
        <property type="entry name" value="Tau95_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="Transcription factor IIIC subunit Tfc1/Sfc1 triple barrel" evidence="15">
        <location>
            <begin position="42"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor IIIC subunit 5 HTH" evidence="14">
        <location>
            <begin position="179"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="475"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="494"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="514"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00057927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00061645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00064690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00069548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00077529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00078452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00081022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF09734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005007436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="526" mass="60055" checksum="9597A6CAE441C45C" modified="2022-01-19" version="1">MGSWAPSGEGWSGMDRAAMAADGPNMERGSGVLELPNTPRLVCVEYPGLVRDVGAMLRTLGGEEGVSRIYADPGKRLELYFRPKDPYCHSVCANRFPASAMLLRVRRRRRKGVEEQDVRFEMEIIGIVSTVYKFQGMSDFQYLAMHSGPDGKQTSMYDKVLMLKPEKEEFFNRELPLYIPPPIFSRLNTPVDYYYRPHVQHREGYNNPQVSAENLIGLSRARRPNNAIFVNFDDEVPDKPLDAAEQAWKKVSTNPVDRKVEEELRKLFEARPVWSRNAVKANISIHPDKLKLLLPCLAYYTITGPWRSLWVRFGYDPRKHPEAKIYQVLDFRIRCGMKYGYTPSDMPVKAKRSAYNYSLPITVKKPGSHTVSVHDLKQGLGAPGASGAKKTASSRYKLKESVYIFREGALPPYRQMFYQLCDLNVESLQKIIHRNDGTESECTERDGWCLPKTSEDLRDSMSLMIKQIIRSTRPALFSSTTSSEDGKEQLAYESGEDEDDEEEEEEDFKPSDGSENEMETEILDYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T3G1</accession>
    <name>A0A8C2T3G1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Avidin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC107305842</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Forms a strong non-covalent specific complex with biotin.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the avidin/streptavidin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015703942.1">
        <property type="nucleotide sequence ID" value="XM_015848456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T3G1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005010748.1">
        <property type="protein sequence ID" value="ENSCJPP00005006892.1"/>
        <property type="gene ID" value="ENSCJPG00005006381.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107305842"/>
    <dbReference type="KEGG" id="cjo:107305842"/>
    <dbReference type="GeneTree" id="ENSGT00390000001847"/>
    <dbReference type="OrthoDB" id="2821340at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome Z"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009374">
        <property type="term" value="F:biotin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.30">
        <property type="entry name" value="Avidin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005469">
        <property type="entry name" value="Avidin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017889">
        <property type="entry name" value="Avidin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036896">
        <property type="entry name" value="Avidin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005468">
        <property type="entry name" value="Avidin/str"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051764">
        <property type="entry name" value="Avidin/Streptavidin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34399:SF3">
        <property type="entry name" value="AVID PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34399">
        <property type="entry name" value="AVIDIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01382">
        <property type="entry name" value="Avidin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00709">
        <property type="entry name" value="AVIDIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50876">
        <property type="entry name" value="Avidin/streptavidin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00577">
        <property type="entry name" value="AVIDIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51326">
        <property type="entry name" value="AVIDIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0092">Biotin</keyword>
    <keyword evidence="6 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041484435" description="Avidin" evidence="10">
        <location>
            <begin position="24"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="26"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR605468-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU369114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="150" mass="16709" checksum="F536C3AB3203A851" modified="2022-01-19" version="1">MVHTASPLLLLLSLALLAPSFSAKQCLLTGKWTNDLGSNMTIGAVSNSGEFSGTYLTAVTATSNEIRVSPLHGTQNRINKRTQPTFGFTVNWKFSESTTVFTGQCFMDRRGKEVLKTMWLLRSSVDDIDDDWKATRVGYNIFTRLHTVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T4B0</accession>
    <name>A0A8C2T4B0_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Histidine triad nucleotide binding protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">HINT2</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine 5'-phosphoramidate + H2O = NH4(+) + AMP</text>
            <dbReference type="Rhea" id="RHEA:67916"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57890"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HINT family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T4B0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005010634.1">
        <property type="protein sequence ID" value="ENSCJPP00005006822.1"/>
        <property type="gene ID" value="ENSCJPG00005006301.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157905"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome Z"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043530">
        <property type="term" value="F:adenosine 5'-monophosphoramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01276">
        <property type="entry name" value="PKCI_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000005">
        <property type="entry name" value="Histidine triad nucleotide-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23089">
        <property type="entry name" value="HISTIDINE TRIAD HIT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="6">
        <location>
            <begin position="70"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="4 5">
        <location>
            <begin position="162"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="3">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="178" mass="19469" checksum="96CB1A313303B5CF" modified="2022-01-19" version="1">GREGRREGRGERGVSWVCRRCHPCKVHDRASTARCAHGRTARCRCVSGGQDGEVGKAQRAANEAGTEATIFSRIIARTVPATILYEDEECLVFRDVAPQAPVHFLVIPKRPIPRLSRVGPQDAQLLGHLMVVAARTAQAEGLSDGYRLVINDGKHGAQSVYHLHLHVLGGRQMNWPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T4Q7</accession>
    <name>A0A8C2T4Q7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Ciliary neurotrophic factor receptor subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">CNTFR</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type I cytokine receptor family. Type 3 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T4Q7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005009881.1">
        <property type="protein sequence ID" value="ENSCJPP00005006253.1"/>
        <property type="gene ID" value="ENSCJPG00005005874.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158864"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome Z"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070110">
        <property type="term" value="C:ciliary neurotrophic factor receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097059">
        <property type="term" value="C:CNTFR-CLCF1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004897">
        <property type="term" value="F:ciliary neurotrophic factor receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019970">
        <property type="term" value="F:interleukin-11 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004921">
        <property type="term" value="F:interleukin-11 receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000136">
        <property type="entry name" value="Ciliary neurotrophic factor receptor alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000564">
        <property type="entry name" value="Ciliary neurotrophic factor receptor subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000944">
        <property type="entry name" value="Ciliary neurotrophic factor receptor subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003530">
        <property type="entry name" value="Hematopoietin_rcpt_L_F3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050379">
        <property type="entry name" value="Type-I_Cytokine_Rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23036:SF21">
        <property type="entry name" value="CILIARY NEUROTROPHIC FACTOR RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23036">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01354">
        <property type="entry name" value="HEMATOPO_REC_L_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="12" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="233"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="16">
        <location>
            <begin position="400"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="518"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="525"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00040625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="562" mass="61703" checksum="024DCADFD74C7BA6" modified="2022-01-19" version="1">MHVSTVPSFGSAPLGVLRACRVRCERLRVQNGARVCVSVQGAVCVEWAASPCTGARAKVRVQGQARGYVCVCVCVCVCVCACAGVGRERAARPGARPRRCAGGCGLSSSLAPRRSLPVASAVTWVMCWSLKELIAPEPVQKQSVVAWGRAGSGGEEGTKKLPDLSDGVQPIVRNQKNLRDFDDKLGTPPGLRTGGEMANPVPSACCVVLAAVVVVYAQRHSQQDSHIQYERVGADVTMKCGSMDWDAAVTWTANGTDIDDSHLNGSYLILKNVDLTQSGQYSCYEGSSWHLKYQTYLRVGVPPKEPLLTCRSNNYPKGFYCVWHLPSPTYIPNSFNISVIHGTREMVCEKDIFPKNRCHIRYLQLFSTVKYKVTLTVTNALGKSSTTLTFDEFAIVKPDPPEFVVAKPVPNNPRRLEVSWQNPSSWPDPESFPLKFFLRYRPLILDQWQHVELSDGTSHTITDAYAGKEYIIQVAAKDNDIGTWSDWSVAVHATPWTEEPKHLTTEVQITGETLTQHKNSALRGPGNGGHSTRGGGKRGTALYHVPSHPCGPVAWLEWLRRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T6J0</accession>
    <name>A0A8C2T6J0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">LOC107305786</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2T6J0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005010904.1">
        <property type="protein sequence ID" value="ENSCJPP00005007021.1"/>
        <property type="gene ID" value="ENSCJPG00005006476.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000175735"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome Z"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030832">
        <property type="term" value="P:regulation of actin filament length"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052409">
        <property type="entry name" value="Myosin-III_kinase_activity"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46256">
        <property type="entry name" value="AGAP011099-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46256:SF5">
        <property type="entry name" value="MYOSIN-IIIB-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="10 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="12 18" id="KW-0505">Motor protein</keyword>
    <keyword evidence="11 18" id="KW-0518">Myosin</keyword>
    <keyword evidence="8 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="17" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Myosin motor" evidence="21">
        <location>
            <begin position="57"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="20">
        <location>
            <begin position="899"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="18">
        <location>
            <begin position="626"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="795"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1011"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1051"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="19">
        <location>
            <begin position="814"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1090"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="154"/>
            <end position="161"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005007021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1111" mass="125455" checksum="814DFFBD9CB9F1BE" modified="2022-01-19" version="1">MAPPPVTCSSSAVAAPRSNRAPPVGAVPGRGCGKASRAAGRAGAGSMGSSGERRGVETEGDLAALAELDEATLLGALRDRFLRQQIYTDVGDILVAVNPFQPLQLYGREVSEQYRCHEKGTLPPHIFAVADRAYQAMLGRRGARPQSQCIVISGESGAGKTESTKLLLQHIMNLCKGNSQLEQQILQVNPLLEAFGNAQTVMNDNSSRFGKYIQLRFQNNTVRGAKLSEYLLEKSRVVQQDTGERNFHIFYYMFAGLSSEQKEMYGLLDPLLYRYISKWFGTEDVAHRWKQKYQEVCNALDMVGFQEQEQVDMQAILAGVLSLGNVTFEPQDSDGSLKVSEGSQGWLKAAAGQFGVQEDELLNCLVCTMSVTRGEQIQRFHTQQQAEDARDSIAKVAYGRVFGWIVCKINELLAENVDPEVELREIGILDIFGFENFAVNRFEQLCINLANEQLQHFFNHHIFQMEQDAYRVEELPWETITFTNNEPVLNLLLAKPLGLMSLLDEQSAFPQATDKTFVDKLNSSFKGNPHFQPSRGCVLGFSIIHYAGKVQYTAGGFLEKNRDTLPANIRGLFINSVTPLLSLLFAASISRTGTLMPHKKTKIVPGADKFNSTRKQSAGTQFRHSLMVLMERMYSANPHFVRCIKPNSQKQPSVVDSQMLLQQLRYNGLLETIRIRRNGFSWRPLFEEFAERYGILLVKPDVPLTKGSCLEILQSTDLTGWLCGKSRLFFKYWHQDQLAKYVEQLERAAVVIQKVFRRFRCRKSYLNLLAELRAQAQRQQEEAERERCRQLAMEAEAQKRISPPVPVPRKRRPLPNPRPQTAPDTPSQPPVPRPRSKLTEFTPFDNFLHPPGPRPAMGTEEQAGEEAKMKQFKRGATLRWFRETQARKVMQDDGAFPSWLHGMISRREAENLLIDKPLGCFLVRISQSRPGYTLTYRGEGRCRHYMIEMQPNARYVILGEDRAHASLTELVRYHQSVGIQPFMEILTVPCEQKSSESLDYKDLECLTLTHSTSTEESLPKEHPGHPTGKSTPQAEAATVFRPLWFRRTNNYQEQQSLDTSRKKQKSGKEGDSQRAFPRLHSSIRMAMQEIQKSSSASLNGSCTELQSSAPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T705</accession>
    <name>A0A8C2T705_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="23">Peroxidasin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">PXDN</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the peroxidase family. XPO subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015714841.1">
        <property type="nucleotide sequence ID" value="XM_015859355.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005014051.1">
        <property type="protein sequence ID" value="ENSCJPP00005009400.1"/>
        <property type="gene ID" value="ENSCJPG00005008255.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107312170"/>
    <dbReference type="KEGG" id="cjo:107312170"/>
    <dbReference type="CTD" id="7837"/>
    <dbReference type="GeneTree" id="ENSGT00940000157666"/>
    <dbReference type="OrthoDB" id="823504at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005201">
        <property type="term" value="F:extracellular matrix structural constituent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043237">
        <property type="term" value="F:laminin-1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
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        <location>
            <begin position="1"/>
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        </location>
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            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
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    <sequence length="1479" mass="166356" checksum="0D3F63DF38B37713" modified="2022-01-19" version="1">MAPPGLCLLLLLLSSAGLAPSASAQPPPQRGSVWCPSRCLCFRSTVRCMHLMLESVPAVSPQTTILDLRFNRIKEIQPGEFRRLKNLNTLLLNNNQIKRIPSGAFEDLENLKYLYLYKNEIQSIDRQAFKGLASLEQLYLHFNQIETLDPESFTHLPKLERLFLHNNRIAHLIPGTFSHLESMKRLRLDSNALHCDCEILWLAELLKTYVESGNAQAAATCEYPRRIQGRSVATITPEELNCERPRITSEPQDVDVTSGNTVYFTCRAEGNPKPEIIWLRNNNELIMKEDSRLNLLDDGTLMIQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPSFVIHPQNTEVLVGESVTLECSATGHPQPQITWTKGDRTPLPSDPRITITPSGGLYIQNVKQEDSGEYTCFATNSMGNIHATAYIIVQALPQFTVTPQDKTVIEGQTVDFPCEAQGYPQPVIAWTKGGGQLSVDRRHLVLSSGTLRISRVALHDQGQYECQAVNIIGSQRIVAHLTVQPRVTPVFASVPSDMTVEVGTNVQIPCSAQGEPEPVITWNKDGVQVTESGKFHVSPEGYLTIRDVGTADEGRYECVARNTIGYSSVSMVLSVNVPNVSRNGDPFVQTSIVEAIATVDRAINSTRTHLFDSRPRSPNDLLALFRYPRDPYTVEQARAGEIFERTLQLIQDHVQDGLMVDLNGTSYHYNDLVSPQYLNLIANLSGCTAHRRVNNCSDMCFHKKYRTHDGSCNNLQHPMWGASLTAFERLLKSVYENGFNLPRGIEPKRLSNGYALPMPRLVSTTLIGTETITPDEQYTHMLMQWGQFLDHDLDLTVAALSEARFSDGQHCSSVCTNDPPCFSIMIPPNDPRVRNGARCMFFVRSSPVCGSGMTSLLMNSVYPREQINQLTSYIDASNVYGSSDHEAQEIRDFASQRGLLRQGIVQRSGKPLLPFATGPPTECMRDENESPIPCFLAGDQRSNEQLGLTSIHTLWFREHNRIATELLKLNPHWDGDTIYHETRKIVGAEMQHITFSHWLPKIFGEVGMKMLGEYKGYDPSVNSGITNEFATAAFRFGHTLINPFLYRLDENFEPIPQGHLPLHKAFFSPFRIVNEGGIDPLLRGLFGVAGKMRVPSQLLNTELTERLFSMARTVALDLAAMNIQRGRDHGIPPYHDFRVYCNLSSAQTFEDLKNEIKNPEIREKLSRLYGSPLNIDLFPALMVEDLVPGSRLGPTLMCLLSTQFRRIRDGDRLWYENPGVFTPAQLTQIKQTSLARVLCDNGDNITRVQHDVFKVAEFPFGYSSCEDIPKLDLRMWQDCCEDCRTRGQFNAFSYHFRGRRSLDYSFQEDKPLKKMKMSKTVSSMKQSKYFRNATSASDENANMPIVNDFKEFVLEMQKTISSLRSQIKKLESRLSKTDCTDEKGKSYSSNETWKRDPCTVCECKVGQITCFVESCPPVDCEAPVKAKGDCCPVCVKESINKKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T753</accession>
    <name>A0A8C2T753_COTJA</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="Ensembl" id="ENSCJPT00005014135.1">
        <property type="protein sequence ID" value="ENSCJPP00005009460.1"/>
        <property type="gene ID" value="ENSCJPG00005008301.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000236567"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="522"/>
            <end position="612"/>
        </location>
    </feature>
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        <location>
            <begin position="625"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="714"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1161"/>
            <end position="1464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="536"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005009460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1540" mass="147335" checksum="683643E10CB47DF5" modified="2022-01-19" version="1">MTSASTKVGEIFSAAGAAFSRLGELTMQLHPMADSPAGAQLRGAARRKAYEEGGLPLPAPTPDSPKRAQRRPGGGGASPEPPPKRPKSTSATAVTLTVQTTASVTPTINVTPTSVNPNSVTSISVTPNSVTSNSDTPTRTSGGASVGSPSTLWTSMDGTGTTGTMTDSTHGTTNGGTTNGGTTNGGTTSTVTSIDVTSSTVTSNDGTTIDVTSSTVTPNDVTSSTVTSNGGTTIDVTSSTVTSNDVTSSTVTPNGGTTIDVTSSTVTSSTVTSIDVTSSTVTSIDDTSSTVTPNGGTTIDVTSSTVTSSTVTSNDGTTIDVTSSTVTSSTVTPNDVTSSTVTSNDDTTIDVTSSAVTSSDVTSTAVTSSATTTIDATSSTVTSSTVTPNGGTTIDVTSSTVTLSDVTSSTVTSSTVTPNDVTSSTVTSNGGTTIDGTSNDVTSPTVTSSDVTSTAVTSIDVTSSTVTSSTVTSSTVTSSTVTSNDGTTIDVTSSTVTSTGTTPTDVTSTAVTSTAIITSTAVTPTEATQSDATTMDVSSPSAASTAVSSSGTTSDVTSTAVTPTGSTPTAVSSTPTSSVSSTVSATTEGASTAVTPSTVTPTGTTPTNVPSSVATTIDVSSSTVTPTAVTSTPTSSVSPTASATTEGVSTAVTSSSVTPTSGTTIHVPSSTVTPTAVTPTATTSSTVTPTGSTPTAVPSSIVTTIDVSSHSAASTAVSSSSGTTSDVPSSTVTSPVVTPTTATPTSVTSTPASSMSSTASATTKGASTAVTSSTVTPTGTTPTNVPSSVTTIDVTSPSAVSSTAVTPTTVTPTEVTTSDVPSSTVTPTGSTPTSVPSTPTSSMSPTASATTNGASTAVTSPGTTPTAVMSSTVTSSTVPSTPTSSMSSTASATTEGTSTAVTSSTVTPTGTTPTNVPSSTVPTIGVTPTSAASTASSSTAVTSPAVTPTTATTTEVTPTALTSSTVPSTVTSSGTTPTAVTSSTVTPTSATTIDVTSPSAASTAVSSSDTTSDVPSSSVTSTGSTPTSVPSTPTSSMSPTASATTEGASTAVTPTSVTPTSGTTIHVPSSTVTPTAVTSTPTSSVSTTTSATTKGASTAVTSSTVTPTAVTSSTISSTAVTPTSVTPTATPSSTVTSTGSTPSDVSSTAITTIDVTSSALTSTATSSLSSTASATTEGASTAVTSSAVTPTSATTIDVTSPSAASTAVTPTTVTPTGTTPTAVTSTAISSTAVSSTSVTPTAVMSSTVTSSDVTSTPTSSMSSTASATTEGASTAVTSSTVTTIDVTSPSAASTAVTPTTVTPTEATTSDVTPTSVPSTPTSSMSSTASATTKGTSSTVPSSTATTIDVSSTSPASTAISSTTVTFSTVTSPDVTPTTVTPTAVSSTPTSLLSSTTSATTEAASTAVTPTTATTTEVTPTSVPFTPTSSMSSTVSATTEGASTAVTSSTVTPTGSTPTAVTSTAVPTIDVTSPSVPSSTVPPTSVPSAAISSTVVTPTSAASTAFSSTVVTSTAVTPPLLQLKHTTSSCHPPLTVPPLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T7G8</accession>
    <name>A0A8C2T7G8_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Homeobox C13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">HOXC13</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Abd-B homeobox family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T7G8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005013060.1">
        <property type="protein sequence ID" value="ENSCJPP00005008632.1"/>
        <property type="gene ID" value="ENSCJPG00005007704.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161087"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140297">
        <property type="term" value="F:DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009952">
        <property type="term" value="P:anterior/posterior pattern specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035878">
        <property type="term" value="P:nail development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043587">
        <property type="term" value="P:tongue morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000130">
        <property type="entry name" value="Homeobox protein Hox-D12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051003">
        <property type="entry name" value="AP_axis_regulatory_Homeobox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022067">
        <property type="entry name" value="HoxA13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45804:SF5">
        <property type="entry name" value="HOMEOBOX PROTEIN HOX-C13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45804">
        <property type="entry name" value="SEGMENTATION PROTEIN FUSHI TARAZU-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12284">
        <property type="entry name" value="HoxA13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0371">Homeobox</keyword>
    <keyword evidence="8 9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="12">
        <location>
            <begin position="223"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="9">
        <location>
            <begin position="225"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="39"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005008632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="330" mass="36298" checksum="BEF42B17665F904C" modified="2022-01-19" version="1">MTAPLGLPPRWSDGLTCRCEEPPREKNRMESLGHCREVLPPPPGLAVPTGAPPAPQGAAYAELAATEPPRQCPSGAASSAALGYGYPFGGGYYGCRLSHSHGVNLQQKPCAYHPGEKYPEAGGPLPGEELPSRPKEFAFYPGFASSYQAVPSYLDVSVVPGLGAHPEPRHDALLPMEGYQHWALSNGWDGQVYCSKEQSQSAHLWKSPFPDVVPLQPEVSSYRRGRKKRVPYTKIQLKELEKEYASSKFITRDKRRKISATTNLSERQVTIWFQNRRVKEKKVVLLGTRCTHGPGKNANPIPSCSWRSWRGSSWSMNSLLAKEGGSSQTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T8E1</accession>
    <name>A0A8C2T8E1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">U3 small nucleolar RNA-associated protein 25 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Digestive organ expansion factor homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UTP25 small subunit processor component</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">UTP25</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the ribosomal small subunit processome for the biogenesis of ribosomes, functions in pre-ribosomal RNA (pre-rRNA) processing. Essential for embryonic development in part through the regulation of p53 pathway. Controls the expansion growth of digestive organs and liver. Also involved in the sympathetic neuronal development. Mediates, with CAPN3, the proteasome-independent degradation of p53/TP53.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with CAPN3; the interaction is required for CAPN3 translocation to the nucleolus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UTP25 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015712855.1">
        <property type="nucleotide sequence ID" value="XM_015857369.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T8E1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005012824.1">
        <property type="protein sequence ID" value="ENSCJPP00005008467.1"/>
        <property type="gene ID" value="ENSCJPG00005007548.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107311106"/>
    <dbReference type="KEGG" id="cjo:107311106"/>
    <dbReference type="CTD" id="27042"/>
    <dbReference type="GeneTree" id="ENSGT00390000000709"/>
    <dbReference type="OrthoDB" id="10264378at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048568">
        <property type="term" value="P:embryonic organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031648">
        <property type="term" value="P:protein destabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902570">
        <property type="term" value="P:protein localization to nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000962">
        <property type="entry name" value="digestive organ expansion factor homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010678">
        <property type="entry name" value="UTP25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053939">
        <property type="entry name" value="UTP25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053940">
        <property type="entry name" value="UTP25_NTPase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12933">
        <property type="entry name" value="ORF PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12933:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 25 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06862">
        <property type="entry name" value="Utp25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22916">
        <property type="entry name" value="UTP25_NTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UTP25 NTP hydrolase-like" evidence="13">
        <location>
            <begin position="305"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="UTP25 C-terminal" evidence="12">
        <location>
            <begin position="582"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="117"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="143"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00055734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00064888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00076595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF06862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF22916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005008467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="772" mass="88753" checksum="2DE677AB1F9104A9" modified="2022-01-19" version="1">MGKRRGGRELVRGLSKRQRKHLRQFGEQHPVCDRVSGRPEATQICELSDNSDKSSAESDSETEVEQVSVYHKLLATLKASPESESEEEEDESESEEAEESEAELDSEGSQEPKEAVGDEEEQDNVPEQEEEVAAKDPPEQALGQEQANGAETSCDPNHGAAEEFTDVKHEAEFSLETNFMEEESGDGDADKTESNSSQALSEDPFKQHMDKELEEKEVEKISMLSKTSSQSKWPRLGQLTFSSSLEKQTTLKPVKEFNVKQLYLHKTLESTWPKVNKHFLTSGNKPGDSSFTPLQRELFCIMNTYRDLFYPERDALTNGEEIRHVYCLHALNHILKANAQVLSNNAKKRDQKPGTDSDDYRDQGLTRPKVLIIVPFRECALRIVHIFISLLEVNEKRKIDVSNKKRFKGEFGSDPDEKPPNLKRPEDYEAVFAGNIDDHFRIGVAILQKSMRLYAPFYSSDIIIASPLGMRTVIGAEGEKKRDFDFLSSIEMLIIDQADIYLMQNWEHVLHLMKHINLLPLDSHGVDFSRVRMPNLNNWSKYYRQTLLFSALQDPQINAIFNKHCFNYMGQVAVRNVPLSGSISHVVVQLPHVFRRIEAENLTSVIDTRFQFFVDKVLPEYRDAIMSHTLIYVPSYFDYVRLRNYFKKEELNFTHICEYTKKASICRARRAFLKGEKQFLVLTERFHFYKRYTIKGIRNLIFYELPTYPHFYSEICNMMKATDSGVDATWTCTVLYTKYDAQKLAAVVGIDRTAQMLQSKKNVHLFVTGENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T8G7</accession>
    <name>A0A8C2T8G7_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Piercer of microtubule wall 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">PIERCE1</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PIERCE1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T8G7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005013803.1">
        <property type="protein sequence ID" value="ENSCJPP00005009218.1"/>
        <property type="gene ID" value="ENSCJPG00005008133.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107321858"/>
    <dbReference type="KEGG" id="cjo:107321858"/>
    <dbReference type="CTD" id="138162"/>
    <dbReference type="GeneTree" id="ENSGT00940000154745"/>
    <dbReference type="OrthoDB" id="546383at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160111">
        <property type="term" value="C:axonemal A tubule inner sheath"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036126">
        <property type="term" value="C:sperm flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035082">
        <property type="term" value="P:axoneme assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071494">
        <property type="term" value="P:cellular response to UV-C"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061966">
        <property type="term" value="P:establishment of left/right asymmetry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030317">
        <property type="term" value="P:flagellated sperm motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026507">
        <property type="entry name" value="PIRC1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20899">
        <property type="entry name" value="PIERCE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20899:SF1">
        <property type="entry name" value="PIERCER OF MICROTUBULE WALL 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14892">
        <property type="entry name" value="PIRC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005009218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="123" mass="13650" checksum="AB19178D235A46AA" modified="2022-01-19" version="1">MAQPQPAEGPAPRSGPWVSSTLPQRFLQLSGFRGYGQPEPHPLYRTTNQEYGRRAPTAYEVPSSYHVTSHAFSDNLGPRGMYRNDGLNTALEKSRVTGPANFITPYDTLDFHPSYKVNGPSHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T8Q1</accession>
    <name>A0A8C2T8Q1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Dual specificity tyrosine-phosphorylation-regulated kinase 1A</fullName>
            <ecNumber evidence="3">2.7.11.23</ecNumber>
            <ecNumber evidence="4">2.7.12.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Protein kinase minibrain homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">DYRK1A</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:10217"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.23" evidence="3"/>
    <dbReference type="EC" id="2.7.12.1" evidence="4"/>
    <dbReference type="RefSeq" id="XP_015737905.1">
        <property type="nucleotide sequence ID" value="XM_015882419.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015737916.1">
        <property type="nucleotide sequence ID" value="XM_015882430.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T8Q1"/>
    <dbReference type="SMR" id="A0A8C2T8Q1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005013361.1">
        <property type="protein sequence ID" value="ENSCJPP00005008878.1"/>
        <property type="gene ID" value="ENSCJPG00005007871.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107323400"/>
    <dbReference type="KEGG" id="cjo:107323400"/>
    <dbReference type="CTD" id="1859"/>
    <dbReference type="GeneTree" id="ENSGT00940000157408"/>
    <dbReference type="OrthoDB" id="9332038at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140857">
        <property type="term" value="F:histone H3T45 kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="F:tau protein binding"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0007623">
        <property type="term" value="P:circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0043518">
        <property type="term" value="P:negative regulation of DNA damage response, signal transduction by p53 class mediator"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0031452">
        <property type="term" value="P:negative regulation of heterochromatin formation"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0031115">
        <property type="term" value="P:negative regulation of microtubule polymerization"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0048025">
        <property type="term" value="P:negative regulation of mRNA splicing, via spliceosome"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:positive regulation of RNA splicing"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:regulation of amyloid-beta formation"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:regulation of neurofibrillary tangle assembly"/>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="PKc_DYRK1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Dual specificity tyrosine-phosphorylation-regulated kinase 1A"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform X3"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044131">
        <property type="entry name" value="PKc_DYR1A/1B"/>
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        <property type="entry name" value="Prot_kinase_dom"/>
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        <property type="entry name" value="Protein_kinase_ATP_BS"/>
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    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
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        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
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        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF121">
        <property type="entry name" value="DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 1A"/>
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        <property type="entry name" value="Pkinase"/>
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        <property type="entry name" value="S_TKc"/>
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        <property type="entry name" value="Protein kinase-like (PK-like)"/>
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    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
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    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
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    <keyword evidence="7" id="KW-0808">Transferase</keyword>
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            <end position="471"/>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T8Z2</accession>
    <name>A0A8C2T8Z2_COTJA</name>
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        <recommendedName>
            <fullName evidence="4">Neurotransmitter-gated ion-channel ligand-binding domain-containing protein</fullName>
        </recommendedName>
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        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
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        <lineage>
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            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
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    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Synaptic cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
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        <property type="protein sequence ID" value="ENSCJPP00005010005.1"/>
        <property type="gene ID" value="ENSCJPG00005008762.1"/>
    </dbReference>
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        <property type="component" value="Chromosome 13"/>
    </dbReference>
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        <property type="term" value="C:synaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Neur_chan_lig-bd"/>
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        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
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        <property type="entry name" value="Neur_channel"/>
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    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
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        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0770">Synapse</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034056837" description="Neurotransmitter-gated ion-channel ligand-binding domain-containing protein" evidence="3">
        <location>
            <begin position="25"/>
            <end position="180"/>
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            <begin position="38"/>
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    </feature>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
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        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005010005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="180" mass="20612" checksum="75E6FA8582A7B803" modified="2022-01-19" version="1">MLRVRKKGYFGIWSFPLIIAVVCAQSVNDPSNMSLVKETVDRLLKGYDIRLRPDFGGPPVAVGMNIDIASIDMVSEVNMDYTLTMYFQQAWRDKRLSYNVIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRTQSLELLQNTSIHSRRVGSWFLNTSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TB97</accession>
    <name>A0A8C2TB97_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrator complex subunit 12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">INTS12</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the Integrator complex, composed of core subunits INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L, INTS12, INTS13, INTS14 and INTS15. The core complex associates with protein phosphatase 2A subunits PPP2CA and PPP2R1A, to form the Integrator-PP2A (INTAC) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Integrator subunit 12 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015716911.1">
        <property type="nucleotide sequence ID" value="XM_015861425.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TB97"/>
    <dbReference type="Ensembl" id="ENSCJPT00005016300.1">
        <property type="protein sequence ID" value="ENSCJPP00005011109.1"/>
        <property type="gene ID" value="ENSCJPG00005009577.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107313294"/>
    <dbReference type="KEGG" id="cjo:107313294"/>
    <dbReference type="CTD" id="57117"/>
    <dbReference type="GeneTree" id="ENSGT00390000005218"/>
    <dbReference type="OrthoDB" id="5846437at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160232">
        <property type="term" value="C:INTAC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160240">
        <property type="term" value="P:RNA polymerase II transcription initiation surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034472">
        <property type="term" value="P:snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15501">
        <property type="entry name" value="PHD_Int12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000101">
        <property type="entry name" value="Integrator complex subunit 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039054">
        <property type="entry name" value="Int12_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051776">
        <property type="entry name" value="Integrator_subunit_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13415:SF2">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13415">
        <property type="entry name" value="NUCLEAR FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="11">
        <location>
            <begin position="204"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="86"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="351"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="133"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="171"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="351"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="396"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="435"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="453"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="471"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="496"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00063548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005011109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="509" mass="53428" checksum="F55FD222875F8BD3" modified="2022-01-19" version="1">MRVPPGSAPAAQRSALPPAERAGTGAVYRLRALSGGYYRLSSDTTMAAAVNMELDPIFLKALGFLRSKSKDSAEKLKALLDESLARGADSSYRPSQKEVEQPKVCVTKPVSSKQDPKASSSLPSGNNNGKPTTSEKVKKETEKRSADKMKGDAAEGADVPKKPRLEKQETRSSPITVQTSKDLSMPDLSSFEETSADDFAMEMGLACVVCRQMTVISGNQLVECQECHNLYHQDCHKPQVTDKEVNDPRLVWYCARCTRQMKRMAQKTQKPPQKPAPAVVSVEPAVKDPLIKKSEIKLKPETQTTFLAFKRTEVKPSAAVSGNSASTSVSSSATTSGLTGWAAFAARNSSANPSTAKLGSTAQNASGKPAAASNNQKPVGLSGLAASKTGLGSKIASANNSTSPVQLKPPPPLTLGKTTLSRSVSSDNVSKVGLPSPSSTAPSTSSQVSSGNGNSGTAGSSGGNTSKTTADAGNQSASLKGPTSQESQLNAMKRLQMVKKKAAQKKLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TCI7</accession>
    <name>A0A8C2TCI7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">THO complex subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Nuclear matrix protein p84</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">THOC1</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus matrix</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the THOC1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TCI7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005015755.1">
        <property type="protein sequence ID" value="ENSCJPP00005010674.1"/>
        <property type="gene ID" value="ENSCJPG00005009262.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000016232"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08318">
        <property type="entry name" value="Death_NMPP84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.533.10:FF:000025">
        <property type="entry name" value="THO complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021861">
        <property type="entry name" value="THO_THOC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13265">
        <property type="entry name" value="THO COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13265:SF2">
        <property type="entry name" value="THO COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11957">
        <property type="entry name" value="efThoc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00005">
        <property type="entry name" value="DEATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="17" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="16" id="KW-0804">Transcription</keyword>
    <keyword evidence="14" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="11" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Death" evidence="23">
        <location>
            <begin position="184"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="135"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00061272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00069888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00080564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005010674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="260" mass="29801" checksum="5A0EF17B9936A26C" modified="2022-01-19" version="1">FVFCRPPDSKPMRPARKRPAPEDFLGKGPNKRILMGNEELTRLWNLCPDNMEACKSESREYMPTLEEFFEEAIEQADPENMVENKYKAVNNSNYGWRALRLLARRSPHFFQPTNQQFKSLPEYLENMVIKLAKELPPPSEEIKTGEDEDEEDNDALLKENNESPEAQRDKPMTGEQMEAFAIRLGEHWRVLAPYLEMKDSDIRQIEADSDDVKMRAKQLLVAWQDQEGAHATPENLITALNKAGLGDLAESLTNDTDSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TCK3</accession>
    <name>A0A8C2TCK3_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein-signaling modulator 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TCK3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005014200.1">
        <property type="protein sequence ID" value="ENSCJPP00005009519.1"/>
        <property type="gene ID" value="ENSCJPG00005008351.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154667"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001965">
        <property type="term" value="F:G-protein alpha-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005092">
        <property type="term" value="F:GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003109">
        <property type="entry name" value="GoLoco_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052386">
        <property type="entry name" value="GPSM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45954:SF2">
        <property type="entry name" value="G-PROTEIN-SIGNALING MODULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45954">
        <property type="entry name" value="LD33695P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02188">
        <property type="entry name" value="GoLoco"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00390">
        <property type="entry name" value="GoLoco"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50877">
        <property type="entry name" value="GOLOCO"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0802">TPR repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="197"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005009519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="221" mass="24270" checksum="9831DE4D44FD85EF" modified="2022-01-19" version="1">MPRLSGSHSSAADGAPQGTARPSAHTAPSLGPAAGRKINRTPSDEECFFDLLSKFQSNRMDDQRCPLEECPSEAAEAAATPVPALEERIPHSSMMASPQTEEFFDLIASSQSRRLDDQRANVGNLPGLRITHNNLGHLCMEGDAQEPGDEFFNMLMKCQSSRIDDQRCAPPDSIPRGPTMPDEDFFSLIQRVQAKRMDEQRVDLASAQEEAEEEQQRPGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TCN2</accession>
    <name>A0A8C2TCN2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Max dimerization protein 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Max-associated protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">MXD3</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TCN2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005017047.1">
        <property type="protein sequence ID" value="ENSCJPP00005011674.1"/>
        <property type="gene ID" value="ENSCJPG00005010018.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161050"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11969:SF6">
        <property type="entry name" value="MAX DIMERIZATION PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11969">
        <property type="entry name" value="MAX DIMERIZATION, MAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="10">
        <location>
            <begin position="76"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="61"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="158"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005011674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="219" mass="24151" checksum="7238C0C1A4D45A18" modified="2022-01-19" version="1">MGAAAAASRGARTRRGPAAATERAASSIQVLLQAAEFLERRERRHRVPPCLAEAEHGYASPCPARPRQRGGARGRAVPRSTDRRSGRRRAQLRRCLEQLKQQVPLGAGPARSTTLSLLRRARLHIQRLQEQEVTAQRVKDRLRSRQRNLRQRLEQLLSPGGTERIRADSLDSSRLSEQSGSDGEEAEIDVEGAGLGAEPLVGFSTGRDHSYSSPRSPWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TCQ8</accession>
    <name>A0A8C2TCQ8_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">THAP domain containing 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">THAP9</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015717046.1">
        <property type="nucleotide sequence ID" value="XM_015861560.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TCQ8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005017084.1">
        <property type="protein sequence ID" value="ENSCJPP00005011710.1"/>
        <property type="gene ID" value="ENSCJPG00005010042.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107313397"/>
    <dbReference type="KEGG" id="cjo:107313397"/>
    <dbReference type="CTD" id="79725"/>
    <dbReference type="GeneTree" id="ENSGT00940000161474"/>
    <dbReference type="OrthoDB" id="7312725at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:DNA transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021896">
        <property type="entry name" value="THAP9-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055035">
        <property type="entry name" value="THAP9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048366">
        <property type="entry name" value="TNP-like_GBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048367">
        <property type="entry name" value="TNP-like_RNaseH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048365">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47577:SF2">
        <property type="entry name" value="THAP DOMAIN CONTAINING 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47577">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22824">
        <property type="entry name" value="THAP9_C"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF21788">
        <property type="entry name" value="TNP-like_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21789">
        <property type="entry name" value="TNP-like_RNaseH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21787">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12017">
        <property type="entry name" value="Tnp_P_element"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="7">
        <location>
            <begin position="52"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="134"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="165"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005011710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="893" mass="99449" checksum="15AF5CE78CC0D486" modified="2022-01-19" version="1">MQRARQRAEPGAGHLLPPVSDRAAGGTAPYTALPPDPPHSALPTPFGPTQPYPPYRPHSALPTPFRPTQPFPPYRRFPVDAAQRLQWIRAVNRVDPRSRRLWLPGPGAILCSRHFAEADFERYGLRRKLRRGAVPSRFPQPEPPRGHPRKVPLRCAPRSQDHTYSRSGAGPASPSAATRRLRGPVPELAARHGLPRAALRVLRALFPDLPRAAQHWRRPAEYCPAMRRFACLLHLRHRAAYEQLRKVFPLPHPASLTNWLSNNAAAPGFCNDMFLQLQEKVERGEQAYCHCALMVREMSLQKCQEWDRQTQRLTGFIDLGAGSLDADEAPLASEVVVIMAAGISSPWRAPLGYFFVSSVTGSLLAQLLRQAISKLNNIGVTVLAVTSGATAYGAETARALGVRLNPKRIRCTFHHPPSSAHCIAFFFDVCYALRLIRNTLQYFQKIQWLGDTVHWHHVVELATLQEEKLLRPRSGHPVSEETYQLKVNLATPLFSEGVADALEHLQKLGLASFQNCGGTVKFLRTMSRLCDVFHGRGPYGSALKGPLLAANYNRISPLFQEAKSFFVSLTDSTGRYIIKSKRRLGFLSFLLNAESLKWLYSNPVLQEGAPSHHFLTSAFSLDPLEWFLWSLRQACSAGSRSPTCAMFQAAYRKVLAGCSLAPDTPHSTASISSLDPSLPHRTDLTLGSICSQYNPARESMPAAELPCRAGLLLCDFPLSNALTDLSLHKQSITFAAGLVAEQLASSLRCEACVASLFESDGSRLRCGAVLYIKKLHRLSLPSASVHHVAHISERVLSRHGQLGDDNKNSKLQYLSLEQNIFHELLGQNHLFPTLSEHLFEGGLHIDNHYTILVKRIAECYLNIRTNQAQKLNLSYYCGRHRLKRVKGKHLLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TE29</accession>
    <name>A0A8C2TE29_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Jouberin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">AHI1</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Involved in vesicle trafficking and required for ciliogenesis, formation of primary non-motile cilium, and recruitment of RAB8A to the basal body of primary cilium. Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Involved in neuronal differentiation. As a positive modulator of classical Wnt signaling, may play a crucial role in ciliary signaling during cerebellum embryonic development.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell junction</location>
            <location evidence="3">Adherens junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Cilium basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015713919.1">
        <property type="nucleotide sequence ID" value="XM_015858433.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015713920.1">
        <property type="nucleotide sequence ID" value="XM_015858434.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015713921.1">
        <property type="nucleotide sequence ID" value="XM_015858435.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TE29"/>
    <dbReference type="Ensembl" id="ENSCJPT00005015073.1">
        <property type="protein sequence ID" value="ENSCJPP00005010131.1"/>
        <property type="gene ID" value="ENSCJPG00005008874.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107311691"/>
    <dbReference type="KEGG" id="cjo:107311691"/>
    <dbReference type="CTD" id="54806"/>
    <dbReference type="GeneTree" id="ENSGT00940000156509"/>
    <dbReference type="OrthoDB" id="2096344at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044458">
        <property type="term" value="P:motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11812">
        <property type="entry name" value="SH3_AHI-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000112">
        <property type="entry name" value="jouberin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000132">
        <property type="entry name" value="jouberin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035832">
        <property type="entry name" value="AHI1_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052803">
        <property type="entry name" value="Cilium-Associated_Jouberin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44499">
        <property type="entry name" value="JOUBERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44499:SF1">
        <property type="entry name" value="JOUBERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0965">Cell junction</keyword>
    <keyword evidence="15" id="KW-0966">Cell projection</keyword>
    <keyword evidence="13" id="KW-0969">Cilium</keyword>
    <keyword evidence="11" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="20" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="10" id="KW-0221">Differentiation</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 18" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="8 19" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="19">
        <location>
            <begin position="635"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="19">
        <location>
            <begin position="678"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="19">
        <location>
            <begin position="725"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="19">
        <location>
            <begin position="835"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="22">
        <location>
            <begin position="1047"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="54"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="130"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="275"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1113"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="175"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="130"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="21">
        <location>
            <begin position="287"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="1153"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="1192"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="1218"/>
            <end position="1228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00058395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00071144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005010131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1239" mass="140158" checksum="EF1FADACD6D4582A" modified="2022-01-19" version="1">MPTVESEAKAKTKVRFEEIFRRHAGLTDENKSRKKKFPSQENIVLDTFRSNIDLTKENGNDESIINNTYNQEEESPRFTKNRDKASHSEKINNDVVSEEASKQTKSNKKKKKSLLQEQFNEEENLCEAKSERLEKKKNDFPKKKTKSKSQTDVPHQEGDGKIKNSFTEVRNATELEEEEELIQAYQLHVAENEVNAIKKKIRMKLKEQMSEFTSALQSHEVLLSDEAGKKKKKKKEVAVVCEAETSAMSLSELQHHPGEGDNENHLLEREFVSEGQNLEESMEKQKPKVKQVKKKTKKDNSGITAENDEEMKTSEISTQSKIGSDDDLVLGVYIHRSDRLKTDLVSHPVVKIHIVDQRSGSYVKKEHRERKVVSYYEEEQIDHILPIMTQPYDLRQFKSTVPEWEEQLIFNERFNYFIQNTEESPQVILFFEILDFLSMDEVRVSSDARIQDSGFRKICWAFLKLVGANGVLNVDGKLRLQLYYPPSKTRSHSDIVEVYDWWAKCPRNRYPSTLYVTVRGIKLPDHVAPSFRSMVAVQQEQSSAALSELHGEGSRKSCEVSSPEEKKEQLKWSRLPGQACRIPNKHLFSLRGGDMGCFCIRFSRDGRTLAAACAGKNGYPIALYEIPSGQFLREFYGHLNIVYDLCWSKDSKHLLTASSDGTVRMWKIETQVASAMKVFPHPSFVYTAKYHPVADFLVVTGCYDAVIRIWNANVNEINGQLLQELDGHKSFINTLCFDTEGLHMFSGDSSGLIIVWDTSVKGSSQCLFQHWKINKEIKENDLRGTPINHLEVHPNGRRLLIHAKDSTLRITDLRILATKKYIGATNYREKIHSTLTPCGTFLFSGSEDGKAYVWNPETGDQVAIYSELSFTSPLRDVAFHPHEHMVSFCAFGPNQPILVYIYDYKVAQQEAELVKDLSSSLSTSAPRGPQISSSFSEIPMQKSSVMSPADQFVSVARTSMRMQKLKQKLDSVMTSSNLLLPAPSSLSPDSKLRLPNTLSTPLNPLYSFSGCFSPVGNPLSRTLLGRIQMSDDRLTALGERGGSSCLLEQETVVALYDYTAHRSDELTIHRSDIIQVLYKDNDNWWFGSLANGQQGYFPANYVAGEKEYEEQPSGLVSDCAPLLPKGPQETEESSPTPHKMSPDVSKSGGLKCISERDTDRDSPATQSLKKKKKGVQKNEIENQPYLMGLDSPVSSANGVQNEPTAHGVELKKKKRAVRSSNLRTSGMTNTAFEPECYDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TFA9</accession>
    <name>A0A8C2TFA9_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovocleidin-116-like</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TFA9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005017024.1">
        <property type="protein sequence ID" value="ENSCJPP00005011651.1"/>
        <property type="gene ID" value="ENSCJPG00005010004.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000010702"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990430">
        <property type="term" value="F:extracellular matrix protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031214">
        <property type="term" value="P:biomineral tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009837">
        <property type="entry name" value="MEPE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16510">
        <property type="entry name" value="EXTRACELLULAR MATRIX PHOSPHOGLYCOPROTEIN WITH ASARM MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16510:SF4">
        <property type="entry name" value="MATRIX EXTRACELLULAR PHOSPHOGLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034617508" evidence="2">
        <location>
            <begin position="19"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="572"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="654"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="361"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="574"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="595"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="664"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005011651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="705" mass="73370" checksum="E89C265E6D8BD7BC" modified="2022-01-19" version="1">MRAVFFCLCLCLLGTVLPTPVSIILLKGCNTNHGFFVFKFMHSFMRRNQTQVKKEEGDHQGTIHGRWLGKVDGETLGQGVGSSHVPEDKDSPKPHSHITPVSKVGGRALRPSTGDSISVYPTSTSMEGSGDMGSMLLGEIINGEDGLPQSTRPGEPHGDGNGGNGVTPGDGAVTAGRERATDSEGAGGEGSSHATVPDQGQAGTMVTGDSAITSVTKKEDVHVDAEDIGEFAYIPYVDAATITRGQDGETHVSPKDEVQIFIGRANIQVGENDGSAGSTGATSEANVIPAAVNARPQGYPEESTSMVTVHHGDSATSRPGDHPSAGNSGDGATANHSGQELEAPSPQESTDGEATVTTAAGSQSGKGRSGQRPVGKHSLPATMTTQGARGTASSGLTMGDCSTAVSTPPEKGSQVATAGQEGSREVGTAGPKRQRARIQQEVAPAPDVEGGMVVPEGHGARTQPGVSSAPSTMETEAPERHRSRAQQGVAPVHSMERETVTPERQRARMQPGSARMQPGSARLGQAARPEVAPAPSTAGGIVAPEGHRARVWPGAAPAPGVIRVARPAPSRVYNGDKRDAMGKSTDVPRDPWVWGSTSPQTQHTRGSMVAGSFSHLHGGQRMGSLAELERSRQVEQVRQADRLRLHERALYGLSGVGGPLQPLAAQADSWSADSSQSSEGQWGSRSNSGEEDGEVRGYPHRRRSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TFD7</accession>
    <name>A0A8C2TFD7_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Kinase D interacting substrate 220</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">KIDINS220</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="Ensembl" id="ENSCJPT00005018533.1">
        <property type="protein sequence ID" value="ENSCJPP00005012840.1"/>
        <property type="gene ID" value="ENSCJPG00005008683.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156714"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030165">
        <property type="term" value="F:PDZ domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048813">
        <property type="term" value="P:dendrite morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038180">
        <property type="term" value="P:nerve growth factor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000081">
        <property type="entry name" value="Kinase D-interacting substrate of 220 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000126">
        <property type="entry name" value="Kinase D-interacting substrate of 220 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000047">
        <property type="entry name" value="Kinase D-interacting substrate of 220 kDa B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000044">
        <property type="entry name" value="kinase D-interacting substrate of 220 kDa isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011646">
        <property type="entry name" value="KAP_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052771">
        <property type="entry name" value="Neurotrophin_sig_adaptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057092">
        <property type="entry name" value="SAM_KIDINS220"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24116">
        <property type="entry name" value="KINASE D-INTERACTING SUBSTRATE OF 220 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24116:SF0">
        <property type="entry name" value="KINASE D-INTERACTING SUBSTRATE OF 220 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07693">
        <property type="entry name" value="KAP_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23307">
        <property type="entry name" value="SAM_KIDINS220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="456"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="483"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="615"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="646"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="37"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="70"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="103"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="137"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="170"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="227"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="293"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="326"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="KAP NTPase" evidence="4">
        <location>
            <begin position="399"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="domain" description="Kinase D-interacting substrate of 220 kDa-like SAM" evidence="5">
        <location>
            <begin position="1164"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1133"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1304"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1366"/>
            <end position="1460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1488"/>
            <end position="1534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1546"/>
            <end position="1575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1696"/>
            <end position="1739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="1150"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1311"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1324"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1366"/>
            <end position="1397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1398"/>
            <end position="1424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1427"/>
            <end position="1437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1490"/>
            <end position="1500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1506"/>
            <end position="1529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1555"/>
            <end position="1566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005012840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1739" mass="192748" checksum="30B36ACFAF2F9E39" modified="2022-01-19" version="1">MASLMSQSLLTYAEEGNVPALKALLEKCRDVDERNENGQTPLMLAAEQGNLEIVQELLKKGANCNLEDADNWTALISAAKEGHTAIVAELLSYGVNLEHRDLGGWTALMWASYKGRTEVAKLLLEKGANPNITGMQYSVYPIIWAAGRGHSDIVHLLLQHGAKVNCSDKYGTTPLVWAARKGHLDCVKYLLQMGADVDQEGAVSNCLFSRCYTGLWHTEIVQESVLIGDTVLIGAVRGGHVEIVRALLHKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTETYTKDGETPLIKATKMRNIEIVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNKAGETPYNIDCSHQKSILTQIFGARHLSPTESDGDMLGYDLYSSALADILSEPTMQPPICVGLYAQWGSGKSFLLKKLEDEMKTFAGQQIEPLFQFSWLIVFLTLLLCGGLGLLLAFTVDAKLGIAVSLSLLAVLYIFFTVIYFGGRREGESWNWAWVLSTRLARHIGYLELLLKLMFVNPPELPEQTTKALPVRFLFTDYNRLSSVGGETSLAEMIATLSDACEREFGFLATRLFRVFKTEDTQGKKKWKKTCCLPSFVIFLFILSCVVSAIALLAIFNVEPTNMTVNAILISVTCVVGLAFILNCRTWWQVMDSVLNSQRKRLHHAASKLHKLKSEGFMKVLKCEVELMARMAKTIDSFTQNQTRLVVIIDGLDACEQDKVLQMLDTVRVLFSKGPFIAIFASDPHIIIKAINQNLNSVLRDSNINGHDYMRNIVHLPVFLNSRGLSNAKKLMVASTTNGDVPYTDNAGLHEEIDRRVSQNSLGEMTKLGSKTALNRRDTYRRRQMQRTITRQMSFDLTKLLVTEDWFSDISPQTMRRLLNIVSVTGRLLRANQITFNWDRLASWINLTEQWPYRTSWLILHLEETEGVPDQLTLKTIYERISKNIPTTKDVEPLLEIDGDIRNFEVFLSSRTPVLVARDVRTFLPCTVNLDPKLREIIADVRAARDQMNIGGLPYPTLPLHEAPGRAASLFSQPSSACSSTTSFNGPFNSGVLSPQPHSSYYSGMTGPQHPFYNRPFFAPCLYMPRYYPGSSHLISRPLKTSLSRDQSNGLLCKSGLSRPRQVQPLSGGGGAGAGPTTGVSHVSLSSMSVEAVCEKLKQIDGLDQSMLPQYSAIIRKANINGRVLAQCNTDELKKEMNMNFGDWHLFRSTILEMRNSENQAVQEDPRGAAEHVTSAVSHSELARRPGHSTELPHTELTGLSGQAPYTLNFSFEELNTIGLDEAPPRHSNLSWQSQTRRTPSLSSLNSQDSSIEISKLTDKVQAEYRDAYREYIAQMSQLEGGASSTTVSGRSSPHSSSAFYMGQSTSGGSLHSSAEQEKVKDGEQKQDDGRKSFLLKRNDVIDYSTSGVSTNDASPLDPITEEDEKSDQSGSKLLLGKKSSERTSIFQAADLKLKGVTLRYQKLPSDEDESGTEESDNTPLLKEGKDKKTDGKADKQPKSPEHGSEPIRTFIKAKEYLTDALLDKKDSSDSGVRSNESSPNHSLHNEGTDDSQLEKANLIELEDDSNSGKRGIPHSLSGLQDPAVVRMSICSEDKKSPSESSLIASSPEENWPACQKVYNLNRTPSTVTLNNNSAPNNRANQNFEEIQGMRDPSQIILNPSSGANSTAVQNENLKSVAHKRSQRSSYTRLSKDSSELHTVTASDGAGFGEERESIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TFI5</accession>
    <name>A0A8C2TFI5_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Polyadenylate-binding protein-interacting protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">PAIP1</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015704144.1">
        <property type="nucleotide sequence ID" value="XM_015848658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TFI5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005018734.1">
        <property type="protein sequence ID" value="ENSCJPP00005013008.1"/>
        <property type="gene ID" value="ENSCJPG00005011001.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107305950"/>
    <dbReference type="KEGG" id="cjo:107305950"/>
    <dbReference type="CTD" id="10605"/>
    <dbReference type="GeneTree" id="ENSGT00940000153432"/>
    <dbReference type="OrthoDB" id="8171816at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome Z"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106002">
        <property type="term" value="C:mCRD-mediated mRNA stability complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008494">
        <property type="term" value="F:translation activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070934">
        <property type="term" value="P:CRD-mediated mRNA stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044794">
        <property type="term" value="P:host-mediated activation of viral process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900152">
        <property type="term" value="P:negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000767">
        <property type="term" value="P:positive regulation of cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000016">
        <property type="entry name" value="polyadenylate-binding protein-interacting protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051367">
        <property type="entry name" value="mRNA_TranslReg/HistoneTransl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23254">
        <property type="entry name" value="EIF4G DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23254:SF15">
        <property type="entry name" value="POLYADENYLATE-BINDING PROTEIN-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="MIF4G" evidence="6">
        <location>
            <begin position="149"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00074029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005013008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="469" mass="51913" checksum="1E9B06B650A8BF54" modified="2022-01-19" version="1">MAENFDRAPGAGRGRGRGGGVLAGALENSGGACPGGGGSHGPGAVEQQQNKTSGLLPQQEPLRPPRTAPLGTGSAEHMQTTRILSGPRVSLPTSGPEMAKPQVPVTPVAMSKLSVKAPEFYPSGYNPNFNQNLTDSSFEDGYGGYLTLAEYVQDFLNHLTEQPGCFESEIELFADTLNGWVVTDEALQELVDLIYQQATSVPNFSYMGARLCNYLSHHLTISPQSGNFRQLLLKRCQAEFENRDEAAKGDEVTRKQFHAFVLFLGELYLNLEIKGTKGQVTRAEILQEGLRELLNALFSNPVDSNLICAVKLLKLTGSVLEDAWKDKGKDDMTEVIQRIENVVLDANCSRDVKHMLLKLVELRSSNWGRVLGTSSHTEATPENDPNYFMNEPTFYTSDGIPFTAADPDYQEEYQELLEREDWFPDYEENGTDLSGAGDLYFDDIDDEMDPEIEEAYEKFCLESEHGRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TFU5</accession>
    <name>A0A8C2TFU5_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Calcitonin receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">CALCR</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">G protein-coupled receptor activated by ligand peptides amylin (IAPP), calcitonin (CT/CALCA) and calcitonin gene-related peptide type 1 (CGRP1/CALCA). CALCR interacts with receptor-activity-modifying proteins RAMP1, 2 and 3 to form receptor complexes AMYR1, 2 and 3, respectively. IAPP, CT and CGRP1 activate CALCR and AMYRs with distinct modes of receptor activation resulting in specific phenotypes. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Heterodimer of CALCR and RAMP1, RAMP2 or RAMP3; the receptor complexes function as AMYR1, AMYR2 and AMYR3 receptors, respectively, and respond to amylin/IAPP, calcitonin/CT and CGRP1 ligands. Interacts with GPRASP2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015709048.1">
        <property type="nucleotide sequence ID" value="XM_015853562.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015709049.1">
        <property type="nucleotide sequence ID" value="XM_015853563.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032299013.1">
        <property type="nucleotide sequence ID" value="XM_032443122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TFU5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005016823.1">
        <property type="protein sequence ID" value="ENSCJPP00005011504.1"/>
        <property type="gene ID" value="ENSCJPG00005009889.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107309089"/>
    <dbReference type="KEGG" id="cjo:107309089"/>
    <dbReference type="CTD" id="799"/>
    <dbReference type="GeneTree" id="ENSGT00940000155380"/>
    <dbReference type="OrthoDB" id="16753at2759"/>
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        <property type="term" value="P:positive regulation of cAMP/PKA signal transduction"/>
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        <property type="term" value="P:positive regulation of ERK1 and ERK2 cascade"/>
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        <property type="term" value="P:response to glucocorticoid"/>
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        <property type="entry name" value="GPCR, family 2, extracellular hormone receptor domain"/>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
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        <property type="entry name" value="GPCR_2_secretin-like"/>
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        <property type="entry name" value="CALCITONIN RECEPTOR"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PDF RECEPTOR-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="CTRFAMILY"/>
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        <property type="entry name" value="GPCRSECRETIN"/>
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        <property type="entry name" value="HormR"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
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        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0732">Signal</keyword>
    <keyword evidence="13" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 16" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
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    <sequence length="469" mass="54573" checksum="C32724E65473BC29" modified="2022-01-19" version="1">MKKTTHSCFLLIILLTRIVPSLTATVNYTDPTLEPVVTENSVIRQKIIDSQFKCYERMNRAPPYRKKGLFCNRTWDGWLCWDDTPAGRITAQNCPDYFPDFDPTERASKYCDETGNWFRHPESNRTWSNYTLCNSFTSEKLKMAFILYYMAIVGHALSITSLLISLAIFFYFKSLSCQRITLHKNLFFSYVLNSMFTIAHLIIVVPNPGLVKRDPVSCKVLQFFHQYMLGCNYFWMLCEGIYLHTLIVVAVFAEEQRLHWYYLLGWGFPLLPASIHAVARAKYFNDNCWMSVDTHLLYIVHGPVMAALLVNFFFLLNIVRVLVTKLRDTHRAESNMYMKAVRATLILVPLLGIQFVIIPWRPENRLAGEIYDYIMHILMHYQGLLVATIFCFFNGEVQGALKRQWTQYKTQWGQRRREHCSTRSTSYTATSITEVPVYLYHHDSNNEQLNGRYVDDSELVALKSGETSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TG58</accession>
    <name>A0A8C2TG58_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LDLR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TG58"/>
    <dbReference type="Ensembl" id="ENSCJPT00005019100.1">
        <property type="protein sequence ID" value="ENSCJPP00005013267.1"/>
        <property type="gene ID" value="ENSCJPG00005011204.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162544"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042562">
        <property type="term" value="F:hormone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000240">
        <property type="entry name" value="Vitamin K-dependent protein S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026823">
        <property type="entry name" value="cEGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051221">
        <property type="entry name" value="LDLR-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722:SF12">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12662">
        <property type="entry name" value="cEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14670">
        <property type="entry name" value="FXa_inhibition"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="71"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like calcium-binding" evidence="14">
        <location>
            <begin position="94"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="110"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like calcium-binding" evidence="14">
        <location>
            <begin position="145"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="148"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="47"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005013267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="465" mass="49348" checksum="6D661CC013A6FB88" modified="2022-01-19" version="1">HSAPPGALLGPVAKAHCAGDCPLEQQCGEQQWGCSHSHECIPDAWRCDRESDCSDGSDEAGCEQHLRQPTPCLSHEYPCGLGICLNASLVCSGQRDCADGSDEGGNCSLPCKRPCSQLCYPSPQGPRCWCAPGYQLAEDSMSCVDVDECAEQSKGACSQICLNAPGTYSCACFSGYLLEPDGHICKLGGNLCVTSGPEPVLLVAVQSELLSYGLRSGREEVLLTTDKERTIFSLDYDLVERKVFWMDLATESISWQSLDSSKKGTLKVVAVEGTVISLALDWLSGNLYWIEGQPTSIRVATAGGRWALTLLSERLQGAARLALCPHASTMCFITAAGSRRPGAAVECAAMDGSGRRVVWSRAHSPTGLTFGGAGTRLYWADQGECGAAWRAVGLDPACPQGAAFHVPPRLIPSVSVSAERGAIGSVELDGSHFRLVREGLHGLRLFAVGDGFLLWSTTATNGEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TGQ1</accession>
    <name>A0A8C2TGQ1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Helicase POLQ-like</fullName>
            <ecNumber evidence="15">5.6.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Mus308-like helicase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">POLQ-like helicase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">HELQ</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Single-stranded 3'-5' DNA helicase that plays a key role in homology-driven double-strand break (DSB) repair. Involved in different DSB repair mechanisms that are guided by annealing of extensive stretches of complementary bases at break ends, such as microhomology-mediated end-joining (MMEJ), single-strand annealing (SSA) or synthesis-dependent strand annealing (SDSA). Possesses both DNA unwinding and annealing activities. Forms a complex with RAD51, stimulating HELQ DNA helicase activity and ability to unwing DNA. Efficiently unwinds substrates containing 3' overhangs or a D-loop. In contrast, interaction with the replication protein A (RPA/RP-A) complex inhibits DNA unwinding by HELQ but strongly stimulates DNA strand annealing. Triggers displacement of RPA from single-stranded DNA to facilitate annealing of complementary sequences.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="15"/>
    <dbReference type="RefSeq" id="XP_015717096.1">
        <property type="nucleotide sequence ID" value="XM_015861610.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TGQ1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005017330.1">
        <property type="protein sequence ID" value="ENSCJPP00005011900.1"/>
        <property type="gene ID" value="ENSCJPG00005010173.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107313424"/>
    <dbReference type="KEGG" id="cjo:107313424"/>
    <dbReference type="CTD" id="113510"/>
    <dbReference type="GeneTree" id="ENSGT00940000157350"/>
    <dbReference type="OrthoDB" id="2320933at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090734">
        <property type="term" value="C:site of DNA damage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990518">
        <property type="term" value="F:single-stranded 3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010792">
        <property type="term" value="P:DNA double-strand break processing involved in repair via single-strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097681">
        <property type="term" value="P:double-strand break repair via alternative nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045003">
        <property type="term" value="P:double-strand break repair via synthesis-dependent strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905168">
        <property type="term" value="P:positive regulation of double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd18026">
        <property type="entry name" value="DEXHc_POLQ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.20:FF:000002">
        <property type="entry name" value="helicase POLQ-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000813">
        <property type="entry name" value="helicase POLQ-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001293">
        <property type="entry name" value="helicase POLQ-like isoform X5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000058">
        <property type="entry name" value="Helicase, POLQ like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046931">
        <property type="entry name" value="HTH_61"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048960">
        <property type="entry name" value="POLQ-like_helical"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF12">
        <property type="entry name" value="HELICASE POLQ-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20470">
        <property type="entry name" value="HTH_61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21099">
        <property type="entry name" value="POLQ_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="22">
        <location>
            <begin position="306"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="23">
        <location>
            <begin position="530"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="82"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="180"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="21">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="102"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="184"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="213"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00053573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00069099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00074990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00076391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005011900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1050" mass="117277" checksum="F53FE2BD0CF5A442" modified="2022-01-19" version="1">MAQPVLAVRRRSRISSARKRSHPPVRPGAACSPVALKRRSAGGEGAPAETPCNDDSEEDMFGDYDSFQESDSLLARVLDAQQQHPQDEGMDVNAAGEFAHGNLQSDMDQNKQGNLHTTEDSSIHKVDGYHGFQVSENDSRDTNEELSDSVFDELPSSQLLYLEQMGELSSCSRRSAGTEMMDKCNNSSLDKTRSMSSPCPDSECKNKSTKPSEGSKSDSCKSVSLKDHLKNAMTGNAKAQTPKVSKTKQLKEAILSEEISVARETIGSLSFDIGPFYGLPSKVQHLLRQFRGIETLYEWQHDCLTLKSLQQRKNLIYSLPTSGGKTLVAEILILQELLCRQKDVLMILPYVAIVQEKVWALSSFGIELGFLVEEYAGSKGRFPPIKRRIKKSLYIATIEKGHALVNSLIETDRIDDLGLVVVDELHMIGEGSRGATLEMTLAKILYTSKNTHIVGMSATLNNVGDLQKFLQAEYYTKNFRPVELKEYIKIRDSIYEVDSKAENGFTFSRLLNFKYSSSLEKADPDHIVALVTEVIPKYSCLIFCPTKKNCENVATMVCKYLNKEFRAHREKEKQDLIKNLKDIGNGSICPVLRQTIPFGVAYHHSGLTNDERKSIEEAYSRGVLCLLACTATLAAGVNLPARRVILRAPYVASEFLKKNQYKQMIGRAGRAGIDNAGESILIVQEKDKHLVRDLITSPLENCYSNLLPELTKGMQYLLLSLVGLKIAVTQEEVYSFMCHTLLGVQQQLLLKEKSLSEIVRDELQNLIEKGLLKGKIMEKDQNSASPLTITLLGKATYKGSIDVSYCNLLYKELRKGLEGLVLESSLHLVYLATPYDMVSNCSPDWMLYLRQFNQLSSAEHKVADMVGVPESFIAKKASGQAIRKNVDSAVVNRLYLSFVLYALLKETNIWSVSEKFNMSRGYVQNLLTSAASFASCVLHFCEELEEFWVYKALLTELTKRLTYCVKTELIPLMEVAGVLEARAKQLYNAGYKTLAHVANANPETLVKTIEHLSRRQAKQMVSSAKMLLTEKAEALQEEVEELLKVPTDIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TIV2</accession>
    <name>A0A8C2TIV2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Tetraspanin-12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">TSPAN12</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tetraspanin (TM4SF) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TIV2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005020708.1">
        <property type="protein sequence ID" value="ENSCJPP00005014567.1"/>
        <property type="gene ID" value="ENSCJPG00005012142.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00510000047764"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001525">
        <property type="term" value="P:angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035633">
        <property type="term" value="P:maintenance of blood-brain barrier"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110135">
        <property type="term" value="P:Norrin signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045765">
        <property type="term" value="P:regulation of angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010842">
        <property type="term" value="P:retina layer formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd03157">
        <property type="entry name" value="TM4SF12_like_LEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1450.10:FF:000009">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018503">
        <property type="entry name" value="Tetraspanin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF462">
        <property type="entry name" value="TETRASPANIN-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00421">
        <property type="entry name" value="TM4_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0037">Angiogenesis</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0564">Palmitate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="55"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="90"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="225"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005014567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="321" mass="36977" checksum="AF0F599D101B26B5" modified="2022-01-19" version="1">MAREDSVRCLRCLLYALNLLFWLMSISVLGVSAWIRDYLNNVLTLTAETRVEEAVILTYFPVVHPVMIAVCCFLILVGMLGYCGTVKRNLLLLVWYFGSLLVIFCVELACGVWTYEQEITVPVQWSDMITLKARMTNYGLPRYQWLTHAWNFFQREFKCCGVVYFTDWLEMTEMDWPPDSCCVREFPGCSKQAHHEDLSDLYQEGCGKKMYTFLRGTKQLQVLRFLGISIGVTQILAMILTITLLWALYYDRRDPGADQIMSLKNDTSQQLSCHSVELLKPSLTGIFEHTSTANSFNTHFEMEELHSFTGHSNSNLLLQDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TJQ0</accession>
    <name>A0A8C2TJQ0_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DnaJ heat shock protein family (Hsp40) member C18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">DNAJC18</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TJQ0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005019400.1">
        <property type="protein sequence ID" value="ENSCJPP00005013512.1"/>
        <property type="gene ID" value="ENSCJPG00005011393.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160925"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071218">
        <property type="term" value="P:cellular response to misfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000004">
        <property type="entry name" value="DnaJ (Hsp40) homolog, subfamily B, member 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051100">
        <property type="entry name" value="DnaJ_subfamily_B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015399">
        <property type="entry name" value="DUF1977_DnaJ-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908">
        <property type="entry name" value="AT29763P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908:SF2">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09320">
        <property type="entry name" value="DUF1977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="19"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005013512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="295" mass="34620" checksum="7E352AFB34ECEFAA" modified="2022-01-19" version="1">MTYTAEQLDGVRRIKSCRNYYEILGVERDATEEELKKAYRRLALKFHPDKNRAPGATEAFKAIGNAFAVLSNPEKRLRYDEYGSDHEHVSTGQARHYNYYSEFEADITPEEIFNVFFGGHFPTGNIHMFSNVARDAHYYPRRHRNERAWTQEQEEEENRPQNSYSAFIQLMPVFIIIIVSVITQLMATNPPYSLFYKSIGHVISRETENLQVPYYVDKNFEKNYQGAELQELERTVEKDYIDYIQTSCWKEKQQKSDLSNLAKLYRDERLKQKAESLKLEHCEKLSSLIGMHKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TL57</accession>
    <name>A0A8C2TL57_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ubiquinone biosynthesis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">COQ9</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Membrane-associated protein that warps the membrane surface to access and bind aromatic isoprenes with high specificity, including ubiquinone (CoQ) isoprene intermediates and presents them directly to Coq7, therefore facilitating the Coq7-mediated hydroxylase step. Participates in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer. Heterodimer; two heterodimers of COQ7:COQ9 come together on the same side of the lipid pseudo-bilayer and form a curved tetramer with a hydrophobic surface suitable for membrane interaction. These two tetramers assemble into a soluble octamer with a pseudo-bilayer of lipids captured within. Interacts with COQ7; this interaction allows ubiquinone (CoQ) isoprene intermediates presentation to COQ7 and facilitates the COQ7-mediated hydroxylase step.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the COQ9 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TL57"/>
    <dbReference type="Ensembl" id="ENSCJPT00005020514.1">
        <property type="protein sequence ID" value="ENSCJPP00005014409.1"/>
        <property type="gene ID" value="ENSCJPG00005012032.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000009328"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110142">
        <property type="term" value="C:ubiquinone biosynthesis complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019840">
        <property type="term" value="F:isoprenoid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.10:FF:000004">
        <property type="entry name" value="Ubiquinone biosynthesis protein COQ9, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.10">
        <property type="entry name" value="Tetracycline Repressor, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013718">
        <property type="entry name" value="COQ9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048674">
        <property type="entry name" value="COQ9_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012762">
        <property type="entry name" value="Ubiq_biosynth_COQ9"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02396">
        <property type="entry name" value="diverge_rpsU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21427">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN COQ9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21427:SF19">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN COQ9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08511">
        <property type="entry name" value="COQ9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21392">
        <property type="entry name" value="COQ9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 9" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="domain" description="Ubiquinone biosynthesis protein COQ9 HTH" evidence="12">
        <location>
            <begin position="96"/>
            <end position="126"/>
        </location>
    </feature>
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        <location>
            <begin position="213"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="41"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00062895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF21392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005014409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="335" mass="36894" checksum="6D459EDCD2C97003" modified="2022-01-19" version="1">MAAAAAGGLRRAGWRLWRGRAGLGCQLYKPQQGLHASAALRRVSEEQRKEPPSAAPSYQQQFDTQQADTQPEQEAQSTHTSSTGQGGQESEDYESEEQLQHRILTAALEFVPEHGWTAEAIAEGAKTLGLSAAAAGMFRNDGSELILHFVSQCNSKLSELLEEEQNQVQQGNAEKKPTDQFLRDAVEARLRMVIPYIEKWPQAVSILLLPHNIPSSLNLLTSMIDDIWHYAGDQSTDFNWYTRRAVLTGIYNTTELVMMQDTSPDFEDTWRFLENRVADAMNMGSAAEQVQSTGKALAQGLMGAAVTVSNTEANKAVRAELLHSIPHLTLACLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TLH4</accession>
    <name>A0A8C2TLH4_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fibronectin type III and SPRY domain containing 1 like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">FSD1L</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015705115.1">
        <property type="nucleotide sequence ID" value="XM_015849629.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TLH4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005021749.1">
        <property type="protein sequence ID" value="ENSCJPP00005015326.1"/>
        <property type="gene ID" value="ENSCJPG00005012714.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107306442"/>
    <dbReference type="KEGG" id="cjo:107306442"/>
    <dbReference type="CTD" id="83856"/>
    <dbReference type="GeneTree" id="ENSGT00940000157979"/>
    <dbReference type="OrthoDB" id="9927450at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome Z"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12901">
        <property type="entry name" value="SPRY_PRY_FSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003879">
        <property type="entry name" value="Butyrophylin_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017903">
        <property type="entry name" value="COS_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050617">
        <property type="entry name" value="E3_ligase_FN3/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035742">
        <property type="entry name" value="SPRY/PRY_FSD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24099">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM36-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24099:SF8">
        <property type="entry name" value="FSD1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01407">
        <property type="entry name" value="BUTYPHLNCDUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51262">
        <property type="entry name" value="COS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="COS" evidence="5">
        <location>
            <begin position="105"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="164"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="3">
        <location>
            <begin position="279"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="291"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="297"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="505" mass="56275" checksum="C1AA250A51CE3457" modified="2022-01-19" version="1">MEEQKETLQRIISTLANKIDEIHSFVDMLNQTIKNVQINSSSVISELDDEFDGLYSILDEMRGSMASTIQQEKARKIQALQNQLSQCSKALESSEELLELAAQSLDIKDPVKFSEAARQIKDRVTMASAFRISLKPEVSDSMTHLMVDFTRERHALQTVKFLPVPKAPVIDLAACLVVDNCITVSWRMPEEDSRVDHFVLEYRKTNFDGLARVKDEHSWEVIDYIKATEYTLSGLKFDTKYINVRVQACNKAVAGEYSDPVTLETEAFVFDLDNTSSHLNLKVEDSYVEWEPTGGKGQEKVKGKENKSSGKNTALKSSKRSGTSPKRTSIGGKATAKGNRDRFAGESYTVLGNNAIESGQHYWEVRAQKDCKSYSVGVAYKTLGKYDQLGKTNISWCIHVNNWLQNTLAAKHNNKSKTLDIPVPDRLGVYCNFDGGQLTFYNAVSKVPLYTFRIKFTQPLLPAFMIRCGGLSVSTGLQVPSAVKTLQKSENGLSGSTGSLNNIAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TLN4</accession>
    <name>A0A8C2TLN4_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GDA1/CD39 NTPase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TLN4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005021984.1">
        <property type="protein sequence ID" value="ENSCJPP00005015508.1"/>
        <property type="gene ID" value="ENSCJPG00005012846.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000407">
        <property type="entry name" value="GDA1_CD39_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01150">
        <property type="entry name" value="GDA1_CD39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="62" mass="6856" checksum="182E046F294B5205" modified="2025-10-08" version="2">MNKVKERIPVHLHKSTSIYLGATAGMRLLRYSGSLNSSACVSFLLLSSLCFSSEIKHQFHCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TMP6</accession>
    <name>A0A8C2TMP6_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein YIPF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">YIPF4</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the maintenance of the Golgi structure.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Golgi apparatus membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">cis-Golgi network membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the YIP1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015713268.1">
        <property type="nucleotide sequence ID" value="XM_015857782.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TMP6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005020698.1">
        <property type="protein sequence ID" value="ENSCJPP00005014557.1"/>
        <property type="gene ID" value="ENSCJPG00005012134.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107311326"/>
    <dbReference type="KEGG" id="cjo:107311326"/>
    <dbReference type="CTD" id="84272"/>
    <dbReference type="GeneTree" id="ENSGT00940000153168"/>
    <dbReference type="OrthoDB" id="411251at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045231">
        <property type="entry name" value="Yip1/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236">
        <property type="entry name" value="GOLGI MEMBRANE PROTEIN YIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236:SF7">
        <property type="entry name" value="PROTEIN YIPF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="10">
        <location>
            <begin position="111"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005014557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="251" mass="27926" checksum="11C2F905B0B4FCE9" modified="2022-01-19" version="1">MQPPGPQQQQPPPPPLFAPNNGDFTFVSSADAEDPSGSITTPDVKLNLGGEFIKESSATTFLRQRGYGWLLEVEDDDPEDNKPLLEELDIDLKDIYYKIRCVLMPMPSLGFNRQVVRDNPDFWGPLAVVLFFSMISLYGQFKVVSWIITIWIFGSLTIFLLARVLGGEVAYGQVLGVIGYSLLPLIVIAPVLLVVGSFEVVSTLIKLFGVFWAAYSAASLLVGEEFKTKKPLLIYPIFLLYIYFLSLYTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TNU9</accession>
    <name>A0A8C2TNU9_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">USP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TNU9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005023099.1">
        <property type="protein sequence ID" value="ENSCJPP00005016422.1"/>
        <property type="gene ID" value="ENSCJPG00005013501.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154596"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000119">
        <property type="entry name" value="Ubiquitin specific peptidase 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF727">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="2">
        <location>
            <begin position="99"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005016422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="208" mass="23367" checksum="26474D1B8816D6CB" modified="2022-01-19" version="1">MTIVNKPKSSKSKKSSSRRSGRSKKPTTKMKSRNWGRIPPGKDPNQGRGGAIYCTSSERSKRFTLKDLVINDGIAPPQRILFPPEKICMDWQQTQTVGVGLFNLGNTCFINSALQCLTYTPPLANYMLSLEHTQSCNCQGFCMMCTMETHINRVLCCAHVAIKPAFIVHELKRIGRHFRFGAQEDAHEFLRFTVEAMQQACLHGSANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TPV6</accession>
    <name>A0A8C2TPV6_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">SLC6A1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TPV6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005022007.1">
        <property type="protein sequence ID" value="ENSCJPP00005015531.1"/>
        <property type="gene ID" value="ENSCJPG00005012319.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156027"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098982">
        <property type="term" value="C:GABA-ergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005332">
        <property type="term" value="F:gamma-aminobutyric acid:sodium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008306">
        <property type="term" value="P:associative learning"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051939">
        <property type="term" value="P:gamma-aminobutyric acid import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098658">
        <property type="term" value="P:inorganic anion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007613">
        <property type="term" value="P:memory"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098810">
        <property type="term" value="P:neurotransmitter reuptake"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098719">
        <property type="term" value="P:sodium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd11506">
        <property type="entry name" value="SLC6sbd_GAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002980">
        <property type="entry name" value="Na/ntran_symport_GABA_GAT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037979">
        <property type="entry name" value="Na_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF138">
        <property type="entry name" value="SODIUM- AND CHLORIDE-DEPENDENT GABA TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01195">
        <property type="entry name" value="GAT1TRNSPORT"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00610">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00754">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="8" id="KW-0769">Symport</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="283"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="320"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="434"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="465"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="510"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="549"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="588"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="597"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="391"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="394"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="395"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="611" mass="68589" checksum="F2887E09D89CF4E6" modified="2022-01-19" version="1">MATNGTKVADGQISTEVDASITNDKPKTLVVKVQKKKTDLPDRDTWKGKFDFLMSCVGYAIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLLECSLGQYTSIGGLGVWKLAPMFKGVGLAAAVLSFWLNIYYIVIISWALYYLYNSFTTTLPWKHCENPWNTDRCFSNYTLANTTNMTSAVVEFWERNMHQMTDGLEKPGQIRWPLAITLAIAWILVYFCIWKGVGWTGKVVYFSATYPYVMLLILFFRGVTLPGAKEGILFYITPNFSKLSDSEVWLDAATQIFFSYGLGLGSLIALGSYNPFHNNVYRDSIIVCCINSCTSMFAGFVIFSIVGFMANVTKRPIADVAASGPGLAFLAYPEAVTQLPISPLWAILFFSMLLMLGIDSQVILVHMVQCWLCSFCTVEGFITALVDEFPKLLRNRREIFIAVVCIVSYLIGLSNITQGGIYVFKLFDYYSASGMSLLFLVFFECISISWCYGVNRFYDNIQEMVGYRPCIWWKLCWSFFTPIIVAGVFIFSAVQMTPLTMGSYVFPKWGQGVGWFMALSSMVLIPGYMAYMFLTLKGSLKQRIQVMIQPSEDISHPENGPDQAQQSNSANKEAYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TQ65</accession>
    <name>A0A8C2TQ65_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box protein 16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FBXO16</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TQ65"/>
    <dbReference type="Ensembl" id="ENSCJPT00005022265.1">
        <property type="protein sequence ID" value="ENSCJPP00005015756.1"/>
        <property type="gene ID" value="ENSCJPG00005013006.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159021"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd22172">
        <property type="entry name" value="F-box_FBXO16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052805">
        <property type="entry name" value="GEF_Ubiquitin-Prot_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46857">
        <property type="entry name" value="EPITHELIAL CELL-TRANSFORMING SEQUENCE 2 ONCOGENE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46857:SF2">
        <property type="entry name" value="F-BOX ONLY PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="85"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="280" mass="32956" checksum="2929D6843D07082D" modified="2022-01-19" version="1">MASATSKNTDSPKLQVKMSTWTPLCNQLMNEKVFEERRALFKKWFIKWTDGQRQKILVDQLDLCSLSLQKFCAKQLQDRIPIEALDFTMKLPRVLTLYIFSFLDPRSLCRCAQVSWHWKNLSELDQLWMKKCLRFGWYINFVPTPFEQGIWKRHYIEMVNELHVTRPKTDSKDECVVTKAQKMRSNTPEAKLSAPEKTRKKKKEIPPWRSSDRHPKDTMRFNCLNNYDPIEQARQQIFPGILSRRGVPFRLCSCSSAGRHLVMVLLGANKSKICLPLYHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TQH6</accession>
    <name>A0A8C2TQH6_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DCC-interacting protein 13-alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Adapter protein containing PH domain, PTB domain and leucine zipper motif 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">APPL1</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell projection</location>
            <location evidence="4">Ruffle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasmic vesicle</location>
            <location evidence="3">Phagosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Early endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TQH6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005022770.1">
        <property type="protein sequence ID" value="ENSCJPP00005016160.1"/>
        <property type="gene ID" value="ENSCJPG00005013303.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156624"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032009">
        <property type="term" value="C:early phagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044354">
        <property type="term" value="C:macropinosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001726">
        <property type="term" value="C:ruffle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043422">
        <property type="term" value="F:protein kinase B binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033211">
        <property type="term" value="P:adiponectin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035729">
        <property type="term" value="P:cellular response to hepatocyte growth factor stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008286">
        <property type="term" value="P:insulin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099558">
        <property type="term" value="P:maintenance of synapse structure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905450">
        <property type="term" value="P:negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900017">
        <property type="term" value="P:positive regulation of cytokine production involved in inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046326">
        <property type="term" value="P:positive regulation of D-glucose import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905303">
        <property type="term" value="P:positive regulation of macropinocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048023">
        <property type="term" value="P:positive regulation of melanin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010762">
        <property type="term" value="P:regulation of fibroblast migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000045">
        <property type="term" value="P:regulation of G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903076">
        <property type="term" value="P:regulation of protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034143">
        <property type="term" value="P:regulation of toll-like receptor 4 signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007179">
        <property type="term" value="P:transforming growth factor beta receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd13247">
        <property type="entry name" value="BAR-PH_APPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07631">
        <property type="entry name" value="BAR_APPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13158">
        <property type="entry name" value="PTB_APPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000034">
        <property type="entry name" value="DCC-interacting protein 13-alpha isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000178">
        <property type="entry name" value="DCC-interacting protein 13-alpha isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000067">
        <property type="entry name" value="Putative DCC-interacting protein 13-beta isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047181">
        <property type="entry name" value="DP13A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037929">
        <property type="entry name" value="DP13A_BAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047236">
        <property type="entry name" value="PH_DP13A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047237">
        <property type="entry name" value="PTB_APPL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46415">
        <property type="entry name" value="ADAPTOR PROTEIN, PHOSPHOTYROSINE INTERACTION, PH DOMAIN AND LEUCINE ZIPPER-CONTAINING 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46415:SF3">
        <property type="entry name" value="DCC-INTERACTING PROTEIN 13-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16746">
        <property type="entry name" value="BAR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="11" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7" id="KW-0967">Endosome</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="18">
        <location>
            <begin position="277"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="PID" evidence="17">
        <location>
            <begin position="500"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="397"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="457"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="413"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="468"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00070936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00076400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005016160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="675" mass="75878" checksum="6BAF9CD8B58D9EB9" modified="2022-01-19" version="1">MPGIDKLPIEETLEDSPQTRSLLGVFEEDAAAISNYVNQLFQAMHRVYDAQNELSAATHLTSKLLKEYEKQHFPLGGDDEIMNSTLQQFAKVIDELSSCHAVLSTQLADAMMFPITQFKERDLKEILTLKEVFQIASNDHDAAITRYSRLSKRRENEKIKAEVTEDVYTSRKKQHQTMMHYFCALNTLQYKKKIAVLEPLLGYMQAQISFFKMGSENLTDQLEEFLTNIGTSVQNVRREMECEIENMQQTIEDLEVASDPLYLPDPDPTKFPVHRNLTRKAGYLNARNKTGLVSSSWERQFYFTQGGNLMSQARGDVAGGLVMDIDNCSVMAVDCEDRRYCFQITSFDGKKSSILQAESKKDYEEWICTINNISKQIYLSENPEEIAARVNQSALEAVTPSPSFQQRHESMRPTVQSRPPAARTSSTGSLGSESPALSALSLDSLVAPDTPIQFDIISPVSEDLPGQAKSSGQSGRRTNPFGETGGSKSETEDSILHQLFIVRFLGSMEVKSDESPDVVYETMRQILAARAIHNIFRMTESHLLVTCDCLKLIDPQTQVTRLRFPLPCVVLYATHQENKRLFGFVLRTSGGRADSRQTSICYIFESNNEGEKICDSVGLAKQIAFHAELVRICLGHSILVNGREKAYLESVIFCILQDAYRCSNAVVENSKGFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TQZ8</accession>
    <name>A0A8C2TQZ8_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Striatin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">STRN</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Calmodulin-binding scaffolding protein which is the center of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Part of the core of STRIPAK complexes composed of PP2A catalytic and scaffolding subunits, the striatins (PP2A regulatory subunits), the striatin-associated proteins MOB4, STRIP1 and STRIP2, PDCD10 and members of the STE20 kinases, such as STK24 and STK26. Interacts with CTTNBP2; this interaction may regulate dendritic spine distribution of STRN. Activation of glutamate receptors weakens the interaction with CTTNBP2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Dendritic spine</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat striatin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TQZ8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005022673.1">
        <property type="protein sequence ID" value="ENSCJPP00005016082.1"/>
        <property type="gene ID" value="ENSCJPG00005013041.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183095"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043197">
        <property type="term" value="C:dendritic spine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090443">
        <property type="term" value="C:FAR/SIN/STRIPAK complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070016">
        <property type="term" value="F:armadillo repeat domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030331">
        <property type="term" value="F:nuclear estrogen receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051721">
        <property type="term" value="F:protein phosphatase 2A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001505">
        <property type="entry name" value="Striatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.300:FF:000001">
        <property type="entry name" value="striatin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000079">
        <property type="entry name" value="striatin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000211">
        <property type="entry name" value="striatin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013258">
        <property type="entry name" value="Striatin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051488">
        <property type="entry name" value="WD_repeat_striatin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15653">
        <property type="entry name" value="STRIATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15653:SF2">
        <property type="entry name" value="STRIATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08232">
        <property type="entry name" value="Striatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="11 18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0770">Synapse</keyword>
    <keyword evidence="7 17" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Striatin N-terminal" evidence="20">
        <location>
            <begin position="66"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="17">
        <location>
            <begin position="504"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="17">
        <location>
            <begin position="557"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="17">
        <location>
            <begin position="610"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="17">
        <location>
            <begin position="746"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="289"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="355"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="77"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="19">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="292"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="315"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="355"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="372"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00058972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00063979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00073140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF08232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005016082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="824" mass="90784" checksum="B2D1FA3B8DEF8B44" modified="2022-01-19" version="1">MDEQAGPGVFFSNNNNNNALLLPPPTGGPGLEPGEAAAAAAGGGGAGVSSGGVAAPVSASRAQYSVPGILHFLQHEWGRFEAERAEWEAERAELQAQIAFLQGERKGQENLKKDLVRRIKMLEYALKQERAKYHKLKYGTELNQGDMKPPNYDSDEGNETEIQPQQNSQLIWKQGRQLLRQYLQEVGYTDTILDVKSKQVRALLGLSSDASEKENRNQEPMVNGTEGQIKENAMIGKPELTDSASLLETFKFLENAAADFSDEEDEEDIEGREKTIIDSATIVRKRVLSDSSEDRDTEEALKEFDFLVTSDEGDGESRSSGDGTDWEKEDQCLMPEAWNVDQGVITKLKEQYKKERKGKKGVKRKTTEDMFQPQSYIKQSKQGCGKMMEQSAGPNRSKLQDMLANLRDVDDLPSLQPSVAPSSRPSSSRLIEHEINRTDEVEALTFPPSSGKSFIMGTDETLENELGLGELAGLTVANEADSLTYDIGNNTDALRKTWNPKFTLRSHFDGIRGLAFHPVEPVLITASEDHTLKMWNLQKTAPAKKSASLDVEPIYTFRAHSGPVLCVVMSSNGEQCYSGGTDGLIHGWNTTNPNIDPYDSYDPSVLRGAFVGHTDAVWGLVYSGTHQRLLSCSADGTVRLWKATEVAPALSVFNDNQEMGIPSSVDLVSSDPSLMVASFNTGHTSIFNMETRQRILTLESGVDNSITSCQINRVISHPTLPISITAHEDRHIKFYDNNTGKLIHSMVAHLDAVTSLAVDPNGLYLMSGSHDCSIRLWNLESKTCIQEFTAHRKKFDESIHDVAFHPSKCYIASAGADALAKVFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TRD0</accession>
    <name>A0A8C2TRD0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Synapsin-2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Synapsin II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">SYN2</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. May play a role in noradrenaline secretion by sympathetic neurons.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Can form oligomers with SYN1. Interacts with CAPON.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Synapse</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the synapsin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TRD0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005022030.1">
        <property type="protein sequence ID" value="ENSCJPP00005015550.1"/>
        <property type="gene ID" value="ENSCJPG00005012866.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156062"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098685">
        <property type="term" value="C:Schaffer collateral - CA1 synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017156">
        <property type="term" value="P:calcium-ion regulated exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007269">
        <property type="term" value="P:neurotransmitter secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097091">
        <property type="term" value="P:synaptic vesicle clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000008">
        <property type="entry name" value="Synapsin I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000008">
        <property type="entry name" value="Synapsin III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000151">
        <property type="entry name" value="Synapsin-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001359">
        <property type="entry name" value="Synapsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020898">
        <property type="entry name" value="Synapsin_ATP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019735">
        <property type="entry name" value="Synapsin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019736">
        <property type="entry name" value="Synapsin_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020897">
        <property type="entry name" value="Synapsin_pre-ATP-grasp_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10841">
        <property type="entry name" value="SYNAPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10841:SF20">
        <property type="entry name" value="SYNAPSIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02078">
        <property type="entry name" value="Synapsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02750">
        <property type="entry name" value="Synapsin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10581">
        <property type="entry name" value="Synapsin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01368">
        <property type="entry name" value="SYNAPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00415">
        <property type="entry name" value="SYNAPSIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00416">
        <property type="entry name" value="SYNAPSIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0770">Synapse</keyword>
    <feature type="domain" description="Synapsin pre-ATP-grasp" evidence="10">
        <location>
            <begin position="106"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Synapsin ATP-binding" evidence="11">
        <location>
            <begin position="209"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="19"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00056023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00064131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00069141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00080999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="491" mass="54703" checksum="491F33A6E61E2C93" modified="2022-01-19" version="1">MNFLRRRLSDSSFIANLPNGYMMDLQRPDPQQPPPPSASSAPASGSPAAERRQPPQSAPPQQQQPPQPQQSAGSSFFSSLSNAVKQTAASAGLVDPTSTSSSAAGRKFKLLLVIDEPHTDWAKAFRGKKVHGEYDIKVEQAEFSEINLIAHADGNYAVDIQVFRNGTKVVRSFRPDFVLVRQHSFSMAENEDFRNLIIGLQYAGIPSVNSLESIYNFCDKPWVFAQLVSVYKTLGPEKFPLIEQTFYPNHKEMLTMPTFPVVVKIGHAHSGMGKIKVDNHYDFQDIASVVALTQTYATTEPFIDSKYDIRIQKIGSNYKAYMRTSISGNWKANTGSAMLEQIAMTERYKLWVDTCSEIFGGLDICAVKAVHGKDGKDYIFEVMDCAMPLIGEHQIEDRQHITELVVSKMNQMLSKTPVPSPQRPTATQQPQLPLVPQLLQLTAETAPPEATAWEYILPVQNDLSPAVSDNSIIMHLHHLIAVFLYIMYVLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TSF0</accession>
    <name>A0A8C2TSF0_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein DGCR6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC107321407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the gonadal family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015733776.1">
        <property type="nucleotide sequence ID" value="XM_015878290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TSF0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005024979.1">
        <property type="protein sequence ID" value="ENSCJPP00005017982.1"/>
        <property type="gene ID" value="ENSCJPG00005014600.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107321407"/>
    <dbReference type="KEGG" id="cjo:107321407"/>
    <dbReference type="GeneTree" id="ENSGT00390000017663"/>
    <dbReference type="OrthoDB" id="21617at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010849">
        <property type="entry name" value="Gonadal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13054">
        <property type="entry name" value="DIGEORGE SYNDROME CRITICAL REGION 6 DGCR6 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13054:SF2">
        <property type="entry name" value="PROTEIN DGCR6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07324">
        <property type="entry name" value="DGCR6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005017982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="198" mass="23100" checksum="67EF5CF4C0459E88" modified="2022-01-19" version="1">MERFGGAGYEVAELSRQQERHYRLLSELQELVKALPSSCQQRLSYTTLSDLALALLDGTVFEIVQGLLEIQHLTEKNLYSQRLKLHSEHRGLKQELFHRHKEAQQCCRPHNLPLLRAAQQREMEAVEQRIREEQRMMDEKIVLELDQKVIDQQSTLEKAGVSGFYITTNPQELTLQMNLLELIRKLQQKESESEKAFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TSI3</accession>
    <name>A0A8C2TSI3_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TSI3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005023950.1">
        <property type="protein sequence ID" value="ENSCJPP00005017147.1"/>
        <property type="gene ID" value="ENSCJPG00005014026.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01120000273952"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005017147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="250" mass="25322" checksum="88CE2361D093434C" modified="2022-01-19" version="1">MGHWGWDPPTPTPMLSYLPAAALHPSPPGAPRYCRPRPDAFRRVLPTAAAARSWLPPPPPPAPPPPLRSWLGAGLDAGLGAWLSAGLDAGLDAGLSAELDARLGAGFNAGLGAGLSARLSAGLCAGLDAELSTGLDAGLSSGLYAGLDAGLGAGLDAGLRTGLSAVLCTGLSTAAPQSSVPPARSLPEPDGRGHGPNPTPMAPDGHPMSPSLWDAAPGVRVALFMGETQPSRRARVKITTKKRWGGREEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TVB4</accession>
    <name>A0A8C2TVB4_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytotoxic T-lymphocyte protein 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Cytotoxic T-lymphocyte-associated antigen 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">CTLA4</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TVB4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005026238.1">
        <property type="protein sequence ID" value="ENSCJPP00005018929.1"/>
        <property type="gene ID" value="ENSCJPG00005015379.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063873"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045334">
        <property type="term" value="C:clathrin-coated endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098636">
        <property type="term" value="C:protein complex involved in cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050853">
        <property type="term" value="P:B cell receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:negative regulation of B cell proliferation"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0045590">
        <property type="term" value="P:negative regulation of regulatory T cell differentiation"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:positive regulation of apoptotic process"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:regulation of T cell proliferation"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:T cell receptor signaling pathway"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Cytotoxic T-lymphocyte protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008096">
        <property type="entry name" value="CTLA4"/>
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    <dbReference type="InterPro" id="IPR040216">
        <property type="entry name" value="CTLA4/CD28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11494">
        <property type="entry name" value="CYTOTOXIC T-LYMPHOCYTE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11494:SF8">
        <property type="entry name" value="CYTOTOXIC T-LYMPHOCYTE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01720">
        <property type="entry name" value="CTLANTIGEN4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0391">Immunity</keyword>
    <keyword evidence="14" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034783007" description="Cytotoxic T-lymphocyte protein 4" evidence="16">
        <location>
            <begin position="19"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Immunoglobulin" evidence="18">
        <location>
            <begin position="26"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Immunoglobulin V-set" evidence="17">
        <location>
            <begin position="36"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
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    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005018929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="257" mass="28402" checksum="E8048121873CED8F" modified="2022-01-19" version="1">MLSAWVTVSFLCAATATAKVMEVTQPAIVLANRQGVASLVCNYKHIGNAKEIRVTLLKQTGDKFTEICASTYTTEFKMFSVEDVIQCHVSPSRNNVTLTLTGLQANDTGLYVCKMERMYPPPYFMNKGNGTQLYVIDPEPCPDTAMYLWVLGSTASGFFLYSIIISAVVVGKVVSPINSPCPANNTLCVPRTRRKEREQERMLGTNALGCSGAILLGQCSTDAIMQKENFLDLLFKFVYGSIVLPEWQKTVNLRQLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TW76</accession>
    <name>A0A8C2TW76_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zinc finger CCCH-type containing 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ZC3H6</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TW76"/>
    <dbReference type="Ensembl" id="ENSCJPT00005027053.1">
        <property type="protein sequence ID" value="ENSCJPP00005019543.1"/>
        <property type="gene ID" value="ENSCJPG00005015830.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157396"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000007">
        <property type="entry name" value="Zinc finger CCCH domain-containing protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045124">
        <property type="entry name" value="Su(sable)-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054361">
        <property type="entry name" value="Znf-CCCH_ZC3H4/6/8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13119">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13119:SF22">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22623">
        <property type="entry name" value="zf-CCCH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18345">
        <property type="entry name" value="zf_CCCH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="239"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="267"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="239"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="267"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="168"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="410"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="641"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="694"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="914"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1018"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="26"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="169"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="190"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="452"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="485"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="751"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="933"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="957"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="971"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1048"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1080"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1127"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1143"/>
            <end position="1153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005019543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1163" mass="129069" checksum="AF4D5D49F0A40E98" modified="2022-01-19" version="1">DGEIDDAAYEDVKEHGSKDDKQKNEKGHRKSRKKRKKEKEKKKSKRRRRDKHKVRKCKPHNGRAYFNSSIYRFRQESKLVLNNTIPSIQHGHVSGNYMSSQKMQHKKNVKSKEYDDYSHYSDENFGNYNDEEKDEDFADQLKQYRQAKETSSSDLGLPFMKEPVKKQGMKGIQKGISQRGNNYGVGRGRGMQKKLKRKDRGRGRGGNKGSDGFHEDGKPVKKWVNMSQEFINQHTVEHKGKQICKYFLEGRCIKGEQCKFDHDAEIEKKKEICKFYIQGYCTKGENCIYLHNILLKKFYHTGAKCYQGDKCKFSHAPLTAETKELLDKVLNNEEEPQNEDEKELEELRKRGIVPLPKPPPGVGLLPTPAEQYPFSESDIENYQDPSGDYKKIPSLFEIVVKPTVDLAHKIGKKPPTFYNSSSPPRPPFQGNDPHSQHMYNPGSSPGPGPGMPQGHNGPPMHPGSPGHHPCGGPQGMPQSPPMQGVPPGFLGPQNQSGMPMQGQQGGPPMTPPGLGGSYNAPGVQGHMVNMPRDNHCPPGPQYQQMPGERQPNMNYEPIQNPADFYDNYYSHQAVHNFQPANNSGDGTWHGEFTDHQAHLMAQESHQGGSESDCMSGHMGHKPAINVPDFLPAMQKALYVRLSQKHQRDGDSVSSQGQRAMSKEEDDNVNWYSSSEEEEGNSVKSILKTLKKQSENFRNQQQHSTEQHMLGIPTDPRLAKDKGAGPQAADPRLRASPRSNPRKPSESAALDPRLRDPRMHKVSDSGHASSSLVGAKLDLHHPHTGVKVKQKGMDDDEEDSERELRERAFLIPLEPLPGVTLRDPRSQLRQFSHIKMDVTLMKPNFAKHIVWAPEDLLPIPLPKPDPVSSINLPLPPLIADQRLNKLRNLKNDPHPNVMPADPRLAAKAKNNLVGRSGYLDQPADSHASSSSKLGDPRLQKNVDPRLHRLSNTDTYHGVTKESHPSKFDPRLARSAASSSQPSEAATAKADPDALPPYAPKLSASGVRLGTSGSLLSGISLYDPRDHSSSSDAAPASSGENGENQKKSILKNSAKNDPSLSEDTSLPKPASNVEKNPEGSAEATSDKANSNSKSQAKHSSAAPAVHNLPIQALSGLIRPQYSDPRQVRQPGQVTQTQDNDPNGESDDKSLKDVFKTFDPTASPFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TWG2</accession>
    <name>A0A8C2TWG2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TBC1 domain family member 15</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">GTPase-activating protein RAB7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">TBC1D15</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Acts as a GTPase activating protein for RAB7A. Does not act on RAB4, RAB5 or RAB6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with non-phosphorylated form of RAB8A; phosphorylation of RAB8A at 'Thr-72' disrupts this interaction. Interacts with ARMC12.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015711287.1">
        <property type="nucleotide sequence ID" value="XM_015855801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TWG2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005027514.1">
        <property type="protein sequence ID" value="ENSCJPP00005019910.1"/>
        <property type="gene ID" value="ENSCJPG00005016096.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107310288"/>
    <dbReference type="KEGG" id="cjo:107310288"/>
    <dbReference type="CTD" id="64786"/>
    <dbReference type="GeneTree" id="ENSGT00940000156429"/>
    <dbReference type="OrthoDB" id="10264062at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000005">
        <property type="entry name" value="TBC1 domain family member 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000005">
        <property type="entry name" value="TBC1 domain family member 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021935">
        <property type="entry name" value="SGSM1/2_RBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF300">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12068">
        <property type="entry name" value="PH_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="10">
        <location>
            <begin position="327"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00055283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00065268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00067480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00082539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005019910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="667" mass="76869" checksum="4B424158BCD26C13" modified="2022-01-19" version="1">MAAPPSGKVLYEQDGVFIHPSCGKNDDQDNYISGVLRVIEKENEVIVDWRPQDDTLDTSNILCAGKDSSSVVEWTPAPKEKSSRGADRPNNYEAEWDMVTTVSFKKKPHSNGGATNHTNGESTWSFLFSLTDLKSIKQNKEGMGWSYLVFCLKDDVKLPALHFHHGDSKLFIKCLENHVVLRESPQDKLILLVNSQNKSLSQSFENLLDEPSYGLLQKWKKDPYTVTMGRFSKVTNYIFDSFRLSDPSTQRRPPSEMADFLNDAIPGLKINQQEEPGFEVITRLDLGEQPEVSRREPVSVEEWAKNMDSEGRILNVDYIKQSIFKGGLCHTLRKEAWKFLLGYFPWNSTKEERANLQKRKTDEYFRMKLQWKSVSEEQEKRNSRLRDYRSLIEKDVNRTDRTNKFYEGEDNPGLILLHDILMTYCMYDFDLGYVQGMSDLLSPVLYVMENEVDAFWCFVSYMDQMHQNFEEQMQGMKTQLIQLSTLLRLLDSGFCSYLESQDSGYLYFCFRWLLIRFKREFSFQDILRLWEVMWTGLPCQNFHLLLCCAILESEKQQIMEKQYGFNEILKHINELSMKIDVEYILCKAEAISMQMMDCKELPQAVSEILGIESSSVTPDSDAGEDESGTVLSCPTSLYQSISTPVIAANGTRDSTQQMSEMQSLAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TX56</accession>
    <name>A0A8C2TX56_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Inactive rhomboid protein</fullName>
            <shortName evidence="11">iRhom</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Rhomboid family member</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Rhomboid veinlet-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">RHBDF1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 11">Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Endoplasmic reticulum membrane</location>
            <topology evidence="2 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the peptidase S54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015732795.1">
        <property type="nucleotide sequence ID" value="XM_015877309.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TX56"/>
    <dbReference type="Ensembl" id="ENSCJPT00005027880.1">
        <property type="protein sequence ID" value="ENSCJPP00005020211.1"/>
        <property type="gene ID" value="ENSCJPG00005016281.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107320935"/>
    <dbReference type="CTD" id="64285"/>
    <dbReference type="GeneTree" id="ENSGT00940000156278"/>
    <dbReference type="OrthoDB" id="2146116at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008283">
        <property type="term" value="P:cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050709">
        <property type="term" value="P:negative regulation of protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042058">
        <property type="term" value="P:regulation of epidermal growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061136">
        <property type="term" value="P:regulation of proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1540.10:FF:000001">
        <property type="entry name" value="Putative inactive rhomboid protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051512">
        <property type="entry name" value="Inactive_Rhomboid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022241">
        <property type="entry name" value="iRhom1_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45965">
        <property type="entry name" value="INACTIVE RHOMBOID PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45965:SF4">
        <property type="entry name" value="INACTIVE RHOMBOID PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12595">
        <property type="entry name" value="iRhom1-2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="654"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="690"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="715"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="745"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="771"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="802"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="domain" description="Inactive rhomboid protein 1/2 N-terminal" evidence="14">
        <location>
            <begin position="90"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="13">
        <location>
            <begin position="649"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU369051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF12595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005020211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="853" mass="97474" checksum="F2C18AEB015FFE37" modified="2022-01-19" version="1">MSEARHDSTSSLQRKKPPWLKLDIPVPVPMPVPEEPVQPTRRQAFLRSVSMPADNSRVPSLPHEVRRPVLQRQTSITQTIKRGTADWFGVSKDSDATQKWQRKSLRHCSLRYGKLKPQVIREMDLPSQDNISLTSTETPPPLYVGPCQLGMQKIIDPLARGRAFRMADDNDGYSIPHTPITPGATSLCSFTSSRSGFNRLPRRRKRESVAKMSFRAAAALVKGRSVKDSTLRRAQRRSFTPASFMEEDTVDFPDELDTSFFAREGVLHEELSTYPDEVFESPSEAAVKDTEVKPLDQTDLTGGALDKNELERSHLLLPLERGWRKQKDGGLAQPKVRLRQEVVSVSPQKRGQRIAVPVRKLFAKEKRPYGLGMVGKLTNRTYRKRIDSYVKRQIEDMDDHRPFFTYWVTFVHSLITILAVCIYGIAPVGFSQHETVDSVLRNRGVYENVKYVQQENFWIGPSSEALIHLGAKFSPCMRQDQQVHSFIKAKREKEKHSACCVRNDKSGCVQTSEEECSSTLAVWVKWPHHSSTPMLAGNKRQFGSVCHQDPRVCEQPASMEPHEWPDDITKWPICTKNSAGNYTNHLHMDCVITGRPCCIGTKGRCEITSREYCEFMRGYFHEEATLCSQVHCMDDVCGLLPFLNPEVPDQFYRLWLSLFLHAGILHCLVSVCFQMTILRDLEKLAGWHRISIIYLLSGITGNLASAIFLPYRAEVGPAGSQFGILACLFVELFQSWQILARPWRAFFKLLAVVLFLFAFGLLPWIDNFAHISGFISGFFLSFAFLPYISFGKFDLYRKRCQIIVFQLIFIALFSGLVILFYFYPIKCEWCEFLTCIPFTDKFCEKYDLDAQLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TX85</accession>
    <name>A0A8C2TX85_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Myb-related transcription factor, partner of profilin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC107314900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TX85"/>
    <dbReference type="Ensembl" id="ENSCJPT00005024985.1">
        <property type="protein sequence ID" value="ENSCJPP00005017988.1"/>
        <property type="gene ID" value="ENSCJPG00005014603.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00960000187715"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028002">
        <property type="entry name" value="Myb_DNA-bind_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23098">
        <property type="entry name" value="AGAP001331-PA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23098:SF22">
        <property type="entry name" value="MYB-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13873">
        <property type="entry name" value="Myb_DNA-bind_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="224"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="517"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="550"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005017988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="594" mass="62340" checksum="50C8CE79E7B37040" modified="2022-01-19" version="1">MARRAVAVLRPRPRLPTSRSAELCPHGPPRSPTGLPRAPSFPLGRVARPERGGAALPLPGAAPGRAAAIAARRPAAAPRSAAAPKPPPFPGASAAAAEQAHNPRRGRAGRDGGESRRGGGGRGRGGLGPGPGPGPLPVSTRGARGACAGLARPFLSCAVFPSPAGRGARPSGGGGARGPGRGKGRRRAPSAPLHGEPTGGAVRRRPPPPAPRRRRMAEDSPKRRKANFNEAETEVLIEQVLKHERLLFAAGPGRASPGQKRKVWELIRHKVNPVAACPRDVEDLKKRWRDLKRRDRSKLCRLSQGGGPPGPNAALGLGLLLAPDELPPGAAPARRHHHHHHLPPRAYGSLLHAEAVPIVGGIDTLELPGAAVGEMGFNDDPGPSHQPGLEKMNLKEEIVVKVVEPEESSEDMAVVPPSQEQLPYLGTSGGASSGKVKAKSKGRSQADPVGITEADLVQIQQTQMQVIQSGFDSVNHNLRLLQQGMQDLSNSLSIMAHTLVAIKNVYVKNNTGPTTYTTASTQTTAGYLSPGSPQVSPTEDRGQVQMAGGSSRSSSCSSSSTSQEPGPSEFPRPPLRTIKKEHPNGCYYFCFADM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TY03</accession>
    <name>A0A8C2TY03_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">HIVEP zinc finger 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">HIVEP3</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015739104.1">
        <property type="nucleotide sequence ID" value="XM_015883618.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015739110.1">
        <property type="nucleotide sequence ID" value="XM_015883624.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032304837.1">
        <property type="nucleotide sequence ID" value="XM_032448946.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032304838.1">
        <property type="nucleotide sequence ID" value="XM_032448947.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032304839.1">
        <property type="nucleotide sequence ID" value="XM_032448948.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032304840.1">
        <property type="nucleotide sequence ID" value="XM_032448949.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032304841.1">
        <property type="nucleotide sequence ID" value="XM_032448950.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032304842.1">
        <property type="nucleotide sequence ID" value="XM_032448951.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005026447.1">
        <property type="protein sequence ID" value="ENSCJPP00005019081.1"/>
        <property type="gene ID" value="ENSCJPG00005015494.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005026448.1">
        <property type="protein sequence ID" value="ENSCJPP00005019082.1"/>
        <property type="gene ID" value="ENSCJPG00005015494.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005026449.1">
        <property type="protein sequence ID" value="ENSCJPP00005019083.1"/>
        <property type="gene ID" value="ENSCJPG00005015494.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005026450.1">
        <property type="protein sequence ID" value="ENSCJPP00005019084.1"/>
        <property type="gene ID" value="ENSCJPG00005015494.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107323992"/>
    <dbReference type="KEGG" id="cjo:107323992"/>
    <dbReference type="CTD" id="59269"/>
    <dbReference type="GeneTree" id="ENSGT00940000157218"/>
    <dbReference type="OrthoDB" id="10042249at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035914">
        <property type="term" value="P:skeletal muscle cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000033">
        <property type="entry name" value="Immunodeficiency virus type I enhancer binding protein 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000083">
        <property type="entry name" value="Immunodeficiency virus type I enhancer binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051969">
        <property type="entry name" value="Zinc-finger_DNA-bd_regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034729">
        <property type="entry name" value="Znf_CCHC_HIVEP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45944">
        <property type="entry name" value="SCHNURRI, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45944:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR HIVEP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51811">
        <property type="entry name" value="ZF_CCHC_HIVEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="191"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="219"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC HIVEP-type" evidence="13">
        <location>
            <begin position="655"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="658"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="1772"/>
            <end position="1799"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="1800"/>
            <end position="1829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="271"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="378"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="480"/>
            <end position="500"/>
        </location>
    </feature>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TZM0</accession>
    <name>A0A8C2TZM0_COTJA</name>
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        <recommendedName>
            <fullName evidence="2">Glyoxalase domain-containing protein 5</fullName>
        </recommendedName>
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        <name evidence="4" type="primary">GLOD5</name>
    </gene>
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        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
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            <taxon>Archosauria</taxon>
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            <taxon>Theropoda</taxon>
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            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
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                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
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        <scope>IDENTIFICATION</scope>
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        <text evidence="1">Belongs to the glyoxalase I family.</text>
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    <sequence length="155" mass="17216" checksum="DCE8F51332766A56" modified="2022-01-19" version="1">MLWSRKDMSWKRVMSPPQCFIRHLDHLVLTVKSIEDTAAFYSKVLGMEVVTFKGNRKALRFGNQKFNLHEVGKEFEPKARCPVPGSADICLITEESLDHLLGHLKACGVAIEEGPVARTGAVGPITSVYFRDPDENLIEVSRYITDKNGASGGEP</sequence>
</entry>
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            <taxon>Perdicinae</taxon>
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    </organism>
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        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015728228.1">
        <property type="nucleotide sequence ID" value="XM_015872742.2"/>
    </dbReference>
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    <dbReference type="Ensembl" id="ENSCJPT00005027778.1">
        <property type="protein sequence ID" value="ENSCJPP00005020117.1"/>
        <property type="gene ID" value="ENSCJPG00005016240.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107318647"/>
    <dbReference type="KEGG" id="cjo:107318647"/>
    <dbReference type="CTD" id="374618"/>
    <dbReference type="GeneTree" id="ENSGT00390000018333"/>
    <dbReference type="OrthoDB" id="269872at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23313:SF0">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23313">
        <property type="entry name" value="TSEC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="96"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="33"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="209"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005020117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="385" mass="43296" checksum="2CB4FFDE41B399AB" modified="2022-01-19" version="1">MAAGGSGGALSRVCRAPGGASVLAGSDAVSGELLAREEHYKRLNAELEAKREKLMRQTEEVMKSRQETLSRPISVQTKYCEDGKQRDPLCLKVPSLTHSHTKPSNKKKCASASMAQSRMHSGNKGKMMTLSPEINLETQNADGAVFEDCTDFSLARTVNEIEGKLESDYLDDDIIPNTASEIGAEAQVRFLKAKLHVMQEELDGIMCECRKKDDENQNLKSQLKDTEEEKRRLQRKMSTQQCQAEKYKMLSQEASKKCEGLQQEVAALEKELENLKRAQKQAASSQSATEVRLNRALEEAERCKAELNKLKQSNKDVANQELKTIEELKAENKKLQKQKGELIAGFKKQLKLIDILKRQKMHIEASRMLSFTEEEFMKALEWGNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U2I5</accession>
    <name>A0A8C2U2I5_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribonuclease P/MRP subunit p14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">RPP14</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic/archaeal RNase P protein component 2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2U2I5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005028843.1">
        <property type="protein sequence ID" value="ENSCJPP00005020969.1"/>
        <property type="gene ID" value="ENSCJPG00005016801.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00510000048121"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030681">
        <property type="term" value="C:multimeric ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033204">
        <property type="term" value="F:ribonuclease P RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3250">
        <property type="entry name" value="Ribonuclease P, Pop5 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002759">
        <property type="entry name" value="Pop5/Rpp14/Rnp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038085">
        <property type="entry name" value="Rnp2-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15441">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15441:SF1">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01900">
        <property type="entry name" value="RNase_P_Rpp14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160350">
        <property type="entry name" value="Rnp2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005020969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="132" mass="14338" checksum="FF52FC2ADAB8D45C" modified="2022-01-19" version="1">LAAAFCRRVLRSAAQHCYLRVRLELPDGAARPGAPQLKQLVVTALRELHGEVGAALPVDVLAYEEKTLCAILRVISSGLVKLWSALTLQGFYQNRRCAFRVLQVGGGLPCCHCWAACLSGTFLPIFSLSNSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U2J5</accession>
    <name>A0A8C2U2J5_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">SLIT and NTRK like family member 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">SLITRK4</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLITRK family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2U2J5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005028855.1">
        <property type="protein sequence ID" value="ENSCJPP00005020981.1"/>
        <property type="gene ID" value="ENSCJPG00005016810.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160971"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007409">
        <property type="term" value="P:axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051965">
        <property type="term" value="P:positive regulation of synapse assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000001">
        <property type="entry name" value="SLIT and NTRK-like family, member 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45773:SF3">
        <property type="entry name" value="SLIT AND NTRK-LIKE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45773">
        <property type="entry name" value="SLIT AND NTRK-LIKE PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="650"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="domain" description="LRRCT" evidence="11">
        <location>
            <begin position="246"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="LRRCT" evidence="11">
        <location>
            <begin position="564"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="316"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="318"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005020981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="870" mass="98335" checksum="3449D758F835CF9E" modified="2022-01-19" version="1">MTTEKRFLFSFLLSSLDTLSLFRSLRLLADHKKMFLWLFLVLSSPVSSTTADADISVEICNVCSCVSVENVLYVNCEKVAVYRPNQLKPPWSNFYHLNFQNNLLIILYPNTFLNFTHAVSLQLGNNKLQNIEGGAFLGLSALKQLHLNNNELKILRADTFLGIENLEYLQADYNLIKFIERGAFNKLHKLKVLILNDNLISFLPDNIFRFASLTHLDIRGNRIQKLPYIGVLEHIGRIVELQLEDNPWNCTCDLLPLKAWLENMPYNIYIGEAICETPSDLYGRLLKETNKQELCSMGTGSDFDVRILPPSQLEPGYSTPNGHTTQTSVHRLVTKPPKTTNPSKISGIVAGKALSNRNLSQIVSYQTRVPPLTPCPVPCVCKTHPSDLGLSVNCQERNIESMAELLPKPLNAKKLHVNGNYIKDVDTMDFVEFEGLDLLHLGSNRISAIRGEVFRNLTNLRRLYLNGNQIERLSPEMFAGLHNLQYLYLEYNVIKEILAGTFDLMPNLQLLYLNNNLLRSLPAYIFAGAPLARLNLRNNHFMYLPVSGVLDQLKSLTQIDLEGNPWDCTCDLVALKLWLEKLNEGIVVKELKCETPVQFANIELKSLKNEILCPKLLNKPSALFTSPVPAVSFTTPLGPVRSHPGGPVPLSILILSILVVLILTVFVAFCLLVFVLRRNKKPTVKHEGIGNQECSTMQLQLRKHDHKSNKKDGLGAEAFIPQTIEQMSKSHTCGLKESETGFTFADPPGQKVILRNMNDKEKDLLHVDSRKRLSTIDELDELFPGRDSNVFIQNFLESKKEYNSIGVSGFEIRYPEKQQDKKNKKSLIGGNHSKIVVEQRKSEYFELKAKLQGSPDYLQVLEEQTALNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U3W9</accession>
    <name>A0A8C2U3W9_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Shroom family member 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">SHROOM2</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the shroom family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015742356.1">
        <property type="nucleotide sequence ID" value="XM_015886870.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005031427.1">
        <property type="protein sequence ID" value="ENSCJPP00005022936.1"/>
        <property type="gene ID" value="ENSCJPG00005018219.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107325724"/>
    <dbReference type="KEGG" id="cjo:107325724"/>
    <dbReference type="CTD" id="357"/>
    <dbReference type="GeneTree" id="ENSGT00940000155212"/>
    <dbReference type="OrthoDB" id="10063560at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043296">
        <property type="term" value="C:apical junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06750">
        <property type="entry name" value="PDZ_shroom2_3_4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000100">
        <property type="entry name" value="Shroom family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014800">
        <property type="entry name" value="ASD1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014799">
        <property type="entry name" value="ASD2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027685">
        <property type="entry name" value="Shroom_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15012">
        <property type="entry name" value="APICAL PROTEIN/SHROOM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15012:SF8">
        <property type="entry name" value="PROTEIN SHROOM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08688">
        <property type="entry name" value="ASD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08687">
        <property type="entry name" value="ASD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51306">
        <property type="entry name" value="ASD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51307">
        <property type="entry name" value="ASD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="12">
        <location>
            <begin position="36"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="ASD1" evidence="13">
        <location>
            <begin position="806"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="domain" description="ASD2" evidence="14">
        <location>
            <begin position="1488"/>
            <end position="1785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="236"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="328"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="709"/>
            <end position="744"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="11">
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            <end position="800"/>
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    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="817"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="862"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="937"/>
            <end position="1081"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1107"/>
            <end position="1278"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
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            <end position="1362"/>
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        <location>
            <begin position="1535"/>
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        <location>
            <begin position="1585"/>
            <end position="1606"/>
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            <begin position="1676"/>
            <end position="1732"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="240"/>
            <end position="253"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="11">
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            <begin position="270"/>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U644</accession>
    <name>A0A8C2U644_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UPF0488 protein C8orf33 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC107320921</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0488 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2U644"/>
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        <property type="protein sequence ID" value="ENSCJPP00005023217.1"/>
        <property type="gene ID" value="ENSCJPG00005018449.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000000306"/>
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        <property type="component" value="Chromosome 14"/>
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        <property type="entry name" value="DUF4615"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13602">
        <property type="entry name" value="UPF0488 PROTEIN C8ORF33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13602:SF2">
        <property type="entry name" value="UPF0488 PROTEIN C8ORF33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15393">
        <property type="entry name" value="DUF4615"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
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        </location>
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        <location>
            <begin position="188"/>
            <end position="213"/>
        </location>
    </feature>
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            <begin position="76"/>
            <end position="89"/>
        </location>
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        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005023217.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="227" mass="25173" checksum="002AC403EBFE50E6" modified="2022-01-19" version="1">MERAEFGVVQVPALEKPESAQTASCASIEDGSRDTLNISKPESAPGGNTAIEKPASDGAAQKKKKKKKQNASVSKKSTEETEIKGKAKVEANGCQSKDAAQQDESSQVLKYRWEVDWCVEQLEIGLKTQKSTPKQVEEALRAIKTLRSDKAPLVKKRQIMRTIFGDYRKKMEEELLQNKKCQVIRKRSGACRKSQGSAGSPPESPSTPDTGTVRFTVSQEEFRFNFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U6Q7</accession>
    <name>A0A8C2U6Q7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">small monomeric GTPase</fullName>
            <ecNumber evidence="3">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">NRAS</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="3"/>
    <dbReference type="RefSeq" id="XP_015740675.1">
        <property type="nucleotide sequence ID" value="XM_015885189.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U6Q7"/>
    <dbReference type="SMR" id="A0A8C2U6Q7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005030053.1">
        <property type="protein sequence ID" value="ENSCJPP00005021939.1"/>
        <property type="gene ID" value="ENSCJPG00005017510.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107324818"/>
    <dbReference type="KEGG" id="cjo:107324818"/>
    <dbReference type="CTD" id="4893"/>
    <dbReference type="GeneTree" id="ENSGT00940000158947"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001938">
        <property type="term" value="P:positive regulation of endothelial cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd04138">
        <property type="entry name" value="H_N_K_Ras_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000096">
        <property type="entry name" value="KRAS proto-oncogene, GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005021939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="189" mass="21278" checksum="52A8D86371920698" modified="2022-01-19" version="1">MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAQELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSNEDGNQGCMGLSCIVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U9G2</accession>
    <name>A0A8C2U9G2_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Calcium release activated channel regulator 2B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">CRACR2B</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U9G2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005031912.1">
        <property type="protein sequence ID" value="ENSCJPP00005023264.1"/>
        <property type="gene ID" value="ENSCJPG00005018485.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00440000033504"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032588">
        <property type="term" value="C:trans-Golgi network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002115">
        <property type="term" value="P:store-operated calcium entry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051111">
        <property type="entry name" value="Ca-binding_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46311:SF3">
        <property type="entry name" value="CALCIUM-BINDING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46311">
        <property type="entry name" value="CALCIUM-BINDING PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="71"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="224"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005023264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="439" mass="51616" checksum="2B0F209FF025426E" modified="2022-01-19" version="1">MKSCLECVMWEHSSIFPCPGAKGFEKMENQRSSLLGYVHWEAEEEGDEEDEVTSGASPSSQVSELEDVQVEMLEKARELFQLCDKDEKGFITKLDMQRLQSELPLTLEQLETVFDSLEQNNNGYLTPVEFSMGLGKLIGIDLCQGAGRTDRSSHEETFESGWSDDMDPADDEEKRFCSMMEQLGAAQVFEDPSEVRDLWVRLRKERPELLANFEEFLLRVSSYIREVNHEKESMEQALKRKETDHDREVRCLYEEMEQQIKAERERLICQEALRHNRSNLLQKELRSKEQELEKILYRQKKLERQLQSLNSEQLETRVQNERLRHLNENLLEELEKSKWELEAVKGQLQKLQKEAQNEQEQKDRDVFRVSKNMQKEKQSLLRQLELLREMNKKLRDERDTFEAKKPVSLRKKILIPNHPPFICCCCCHHLGASHIHGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UAA0</accession>
    <name>A0A8C2UAA0_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ankyrin repeat domain 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ANKRD2</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2UAA0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005033844.1">
        <property type="protein sequence ID" value="ENSCJPP00005024856.1"/>
        <property type="gene ID" value="ENSCJPG00005019553.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153956"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061629">
        <property type="term" value="F:RNA polymerase II-specific DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000503">
        <property type="entry name" value="Ankyrin repeat domain 2 (stretch responsive muscle)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000093">
        <property type="entry name" value="ankyrin repeat domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126:SF3">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126">
        <property type="entry name" value="ANKYRIN REPEAT, PH AND SEC7 DOMAIN CONTAINING PROTEIN SECG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="149"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="182"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="215"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="248"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="30"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="42"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="80"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005024856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="314" mass="34257" checksum="BBBE1C1EED5B696B" modified="2022-01-19" version="1">MELDGEKGKELEVEQITELDVEKAKELIDQKLAEEEEEEKVAFSGSSSFASSAASAERSGQPPQSPPHHQSPRRLYVQAAGGGLRQPGIPPGGAGHGAPAVPVPQPCPVLPQEGPVEPEDFLRAAVQGKIRVIEKFLADGGPPDTCDEFHRTALHRSSLEGHMDILQKLLDNGATVDFRDRLDSTAVHWACRGGHLEAVKLLQDRGADLNMKDKLLSTPLHVATRTGHLDIVEHLIHCGVDINSPDREGDTALHDATRLSRYKIIKMLILHGADMMARNLAGKTPTDLVQQWQVDTRQALETKEQPQEEAEVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UAT0</accession>
    <name>A0A8C2UAT0_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tumor protein, translationally-controlled 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">TPT1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TCTP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2UAT0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005034172.1">
        <property type="protein sequence ID" value="ENSCJPP00005025084.1"/>
        <property type="gene ID" value="ENSCJPG00005019733.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000006051"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140297">
        <property type="term" value="F:DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000384">
        <property type="term" value="P:negative regulation of ectoderm development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902230">
        <property type="term" value="P:negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009615">
        <property type="term" value="P:response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019827">
        <property type="term" value="P:stem cell population maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.150.10:FF:000001">
        <property type="entry name" value="Tumor protein, translationally-controlled 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.10">
        <property type="entry name" value="Metal Binding Protein, Guanine Nucleotide Exchange Factor, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011323">
        <property type="entry name" value="Mss4/transl-control_tumour"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034737">
        <property type="entry name" value="TCTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018103">
        <property type="entry name" value="Translation_control_tumour_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018105">
        <property type="entry name" value="Translational_control_tumour_p"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11991">
        <property type="entry name" value="TRANSLATIONALLY CONTROLLED TUMOR PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11991:SF0">
        <property type="entry name" value="TRANSLATIONALLY-CONTROLLED TUMOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00838">
        <property type="entry name" value="TCTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01653">
        <property type="entry name" value="TCTPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01002">
        <property type="entry name" value="TCTP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01003">
        <property type="entry name" value="TCTP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51797">
        <property type="entry name" value="TCTP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TCTP" evidence="2">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005025084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="180" mass="20330" checksum="54102AE681C1EEBA" modified="2022-01-19" version="1">MIIYRDCISQDEMFSDIYKIREVANGLCLEVEGKMVTRTEGQIDDSLIGGNASAEGPEGDGTEATVITGVDIVINHHLQETSFTKESYKKYIKDYMKAIKARLEEHKPERVKPFMTGAAEQIKHILANFKNYQFFVGENMNPDGMVALLDFREDGVTPYMIFFKDGLEIEKCVSTNIELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UB90</accession>
    <name>A0A8C2UB90_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein zer-1 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Zyg-11 homolog B-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ZER1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="6">Interacts with the ELOC-ELOB/Elongin BC complex. Part of an E3 ubiquitin ligase complex including ZER1, CUL2 and Elongin BC.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the zyg-11 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_032303987.1">
        <property type="nucleotide sequence ID" value="XM_032448096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UB90"/>
    <dbReference type="Ensembl" id="ENSCJPT00005035265.1">
        <property type="protein sequence ID" value="ENSCJPP00005025988.1"/>
        <property type="gene ID" value="ENSCJPG00005020303.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107321727"/>
    <dbReference type="KEGG" id="cjo:107321727"/>
    <dbReference type="CTD" id="10444"/>
    <dbReference type="GeneTree" id="ENSGT00530000063187"/>
    <dbReference type="OrthoDB" id="5783533at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031462">
        <property type="term" value="C:Cul2-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032436">
        <property type="term" value="P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000111">
        <property type="entry name" value="Protein zer-1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000085">
        <property type="entry name" value="protein zer-1 homolog isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056845">
        <property type="entry name" value="LRR_Zer-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055142">
        <property type="entry name" value="ZER1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051341">
        <property type="entry name" value="Zyg-11_UBL_adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12904">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12904:SF23">
        <property type="entry name" value="PROTEIN ZER-1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25013">
        <property type="entry name" value="LRR_Zer-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22964">
        <property type="entry name" value="ZER1-like_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Zer-1-like leucine-rich repeats region" evidence="10">
        <location>
            <begin position="193"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Protein zer-1 homolog-like C-terminal" evidence="9">
        <location>
            <begin position="401"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00062951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00067612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00081214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005025988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="766" mass="88168" checksum="C90020A22A78F464" modified="2022-01-19" version="1">MASDSPESLMTLCTDFCLRNLEGTLCYLLDNETLRLHPDIFLPSEICDKLVNEYVELVKTDSIFEPHESFFTLFSDPRSTRLARIHLREQIVQDQDLEAIRKQDLVELYLTNCEKLTAKSLQTLVSFSHTLISLSLFGCCNIFYEEENPGGCEDDCLVNPTRQVLVKDFTFEGFSRLRFLNLGRLIEGVNVETLLRPLTSLAALDLSGIQLNDVGFLTRWKDSLVSLVLYNMDLSEEHIQVIAQLHKLRHLDISRDHLSSYYKFKLTRRVLNLFVENLVNLTSLDISGHTMLENCTIPNMEEKMGQTSIEPAKSSIAPFRGLKRPLQFLGLFETSLCRLTHIPAYKVSGDKNEEQVLNAIEAYTEHRPEITSRAINLLFDIARIERCSQLLRALQLVITALKCHKDDKNIQVTGSAALFYLTNSEYRMEQSIKLRRQVIQVVLNGMESYQEVTVQRNCCLTLCNFSIPEELEFQYRRVNELLLNILNQSRQDESIQRIAVHLCNALVCQVDNDHKEAVGKMGFVMTMLKLIQKKLADKTCDQVMEFSWSALWNITDETPDNCEMFLNYSGMKLFLECLKEFPEKQELHRNMLGLLGNVAEVRELRPQLMTSQFISVFSNLLESKADGIEVSYNACGVLSHIMFDGPEAWGICEPHREEVVKRMWAAIQSWDINSRRNINYRSFEPILRLLPQGISPVSQHWATWALYNLVSVYPDKYCPLLIKEGGIPLLKDMIKMASARQETKEMAWKVIEHCSNFKEENMDTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UBN2</accession>
    <name>A0A8C2UBN2_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">G protein subunit beta 1 like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">GNB1L</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015733042.1">
        <property type="nucleotide sequence ID" value="XM_015877556.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015733048.1">
        <property type="nucleotide sequence ID" value="XM_015877562.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015733050.1">
        <property type="nucleotide sequence ID" value="XM_015877564.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015733051.1">
        <property type="nucleotide sequence ID" value="XM_015877565.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UBN2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005032940.1">
        <property type="protein sequence ID" value="ENSCJPP00005024140.1"/>
        <property type="gene ID" value="ENSCJPG00005019063.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107321052"/>
    <dbReference type="CTD" id="54584"/>
    <dbReference type="GeneTree" id="ENSGT00390000018606"/>
    <dbReference type="OrthoDB" id="7668193at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035176">
        <property type="term" value="P:social behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854:SF1">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="200"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="287"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005024140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="328" mass="36238" checksum="E45F643BF0E27387" modified="2022-01-19" version="1">MAQPPPDPHFVLRGAGAAVHALHFSCGGEEPDIPILFSGSENGFIHVWNLKTHRVDAALDGHGRKSVYWLKTMDGRDRLLSQGRDQRICLWDLAEGRTSVTDSVYTENVGFCRCSLLKAAQGRWLMAMAAKALEEVQVLELPSKTSVCTLKPEVGARLGMPMCLKLWQGSCGSQPSLLAGYEDGSVLLWNLSTGKVLSQIICHQEPVMSLDFDSEKAKGISGSSEKVLSIWSLNEQQNLQVQKTHRLVNAGISDITIRPDKKILATAGWDHRIRIFGWKKMKPLAVLDYHTATVHSVSFSDHKSPSDRLLAAGAKDHRISVWSIYTQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UBX4</accession>
    <name>A0A8C2UBX4_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SWI/SNF related BAF chromatin remodeling complex subunit D2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">SMARCD2</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SMARCD family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2UBX4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005033069.1">
        <property type="protein sequence ID" value="ENSCJPP00005024236.1"/>
        <property type="gene ID" value="ENSCJPG00005019135.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158654"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016514">
        <property type="term" value="C:SWI/SNF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006337">
        <property type="term" value="P:nucleosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd17675">
        <property type="entry name" value="SWIB_BAF60B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.245.10:FF:000001">
        <property type="entry name" value="SWI/SNF-related matrix-associated regulator of chromatin subfamily D member 3 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.245.10">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030090">
        <property type="entry name" value="SMARCD2_SWIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019835">
        <property type="entry name" value="SWIB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036885">
        <property type="entry name" value="SWIB_MDM2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003121">
        <property type="entry name" value="SWIB_MDM2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13844">
        <property type="entry name" value="SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02201">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00151">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47592">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51925">
        <property type="entry name" value="SWIB_MDM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DM2" evidence="3">
        <location>
            <begin position="386"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005024236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="611" mass="69764" checksum="76EEC98E4FC61CE5" modified="2022-01-19" version="1">MWVRRQQGSCRNCLGMSGNLQRGRNAVLLARWLSQLHQFLARGELEDQRITESRQSVLEQVGLSSSGVLGAFVEHTRAVHGADPESAADAGDRDHKNCSRLEFMQQKLNIPRGGGVVNALCRCLEVKGFSTTSIRNEGHPPDVLALVKGPMFNTPLSCLSLPCQRPGMPPGSRMPMAGLQVGPPGAPPYGAASPLRPGLPQSMMDPFRKRLLAPQSQPPMATQRRGVKRRKMADKVLPQRIRELVPESQAYMDLLAFERKLDQTIARKRMEIQEAIKKPLTQKRKLRIYISNTFTPAKEEGEGGERVASWELRVEGKLLEDPSKQKRKFSSFFKSLVIELDKELYGPDNHLVEWHRLPTTQETDGFQVKRPGDVNVKCTLLLMLDHQPPQYKLDPRLARLLGVHTQTRASIMQALWLYIKHNKLQDSHEKEYINCNRYFRQIFNCVRMRFSEIPMKLAGLLQHPDPIIINHTISVDPNDQKKTACYDIDVEVDDPLKAQMSNFLASTTNQQEIASLDAKIHETIESINQLKTQRDFMLSFSNNPQDFIQEWIKSQRRDLKIITDVIGNPEEERRAEFYQQPWAQEAVGRHIFAKVQQRRQELEQVLGIRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UCQ1</accession>
    <name>A0A8C2UCQ1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Vacuolar protein-sorting-associated protein 36</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">ESCRT-II complex subunit VPS36</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">VPS36</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the endosomal sorting complex required for transport II (ESCRT-II).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the VPS36 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015707365.1">
        <property type="nucleotide sequence ID" value="XM_015851879.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UCQ1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005034406.1">
        <property type="protein sequence ID" value="ENSCJPP00005025279.1"/>
        <property type="gene ID" value="ENSCJPG00005019816.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107308189"/>
    <dbReference type="KEGG" id="cjo:107308189"/>
    <dbReference type="CTD" id="51028"/>
    <dbReference type="GeneTree" id="ENSGT00390000017209"/>
    <dbReference type="OrthoDB" id="271448at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13226">
        <property type="entry name" value="PH-GRAM-like_Eap45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000203">
        <property type="entry name" value="Vacuolar protein sorting 36 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000241">
        <property type="entry name" value="Vacuolar protein sorting 36 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000170">
        <property type="entry name" value="Vacuolar protein-sorting-associated protein 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021648">
        <property type="entry name" value="GLUE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040608">
        <property type="entry name" value="Snf8/Vps36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037855">
        <property type="entry name" value="Vps36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13128">
        <property type="entry name" value="VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13128:SF12">
        <property type="entry name" value="VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04157">
        <property type="entry name" value="EAP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11605">
        <property type="entry name" value="Vps36_ESCRT-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51495">
        <property type="entry name" value="GLUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0967">Endosome</keyword>
    <keyword evidence="6 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GLUE N-terminal" evidence="10">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005025279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="386" mass="43672" checksum="CB82758C532A5E48" modified="2022-01-19" version="1">MDRFSWTSGLLELGETLVLQQRGVRLYDGEEKVRFDSGVLLLSTHRLIWRDQKNHECCISIPLSQVVFIEEQAAGIGKSAKIVAHLHPAPPNKEPGPFQNSKYSYIKLSFKEHGQIEFFRRFSEEITQRRWENMPSGQTIQVNKDPQAGRIRAVGIVGIERKLEAKRKETDKNISEAFEDLSKLMEKAKEMVELSKSIANKIKEKQGDITEDETIRFKSYLLSMGIANPVTRETHGSGTHYHMQLAKQLAGMLQTPLEERGGIMSLTEVYCLVNRARGLELLSPEDLVNACKMLEPLKLPLRLQIFDSGVMVIELQSHNEEEMVASALETVSEKGSLTADEFAKLVGMSVLLAKERLLLAEKMGHLCRDDSVEGLRFYPNLFLTQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UCV6</accession>
    <name>A0A8C2UCV6_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Jumonji domain containing 6, arginine demethylase and lysine hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">JMJD6</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-lysyl-[protein] + 2-oxoglutarate + O2 = (5S)-5-hydroxy-L-lysyl-[protein] + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:58360"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:15144"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:141843"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 2-oxoglutarate + 2 O2 = L-arginyl-[protein] + 2 formaldehyde + 2 succinate + 2 CO2</text>
            <dbReference type="Rhea" id="RHEA:58348"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11992"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:88221"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2-oxoglutarate + O2 = N(omega)-methyl-L-arginyl-[protein] + formaldehyde + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:58472"/>
            <dbReference type="Rhea" id="RHEA-COMP:11990"/>
            <dbReference type="Rhea" id="RHEA-COMP:11992"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:65280"/>
            <dbReference type="ChEBI" id="CHEBI:88221"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 5'-end methyltriphosphate-guanosine-ribonucleotide-snRNA + 2-oxoglutarate + O2 = a 5'-end triphospho-guanosine-ribonucleotide-snRNA + formaldehyde + succinate + CO2 + H(+)</text>
            <dbReference type="Rhea" id="RHEA:58784"/>
            <dbReference type="Rhea" id="RHEA-COMP:15220"/>
            <dbReference type="Rhea" id="RHEA-COMP:15221"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:138278"/>
            <dbReference type="ChEBI" id="CHEBI:142789"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the JMJD6 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015735295.1">
        <property type="nucleotide sequence ID" value="XM_015879809.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UCV6"/>
    <dbReference type="SMR" id="A0A8C2UCV6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005036064.1">
        <property type="protein sequence ID" value="ENSCJPP00005026612.1"/>
        <property type="gene ID" value="ENSCJPG00005020698.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107322125"/>
    <dbReference type="KEGG" id="cjo:107322125"/>
    <dbReference type="CTD" id="23210"/>
    <dbReference type="GeneTree" id="ENSGT00940000156867"/>
    <dbReference type="OrthoDB" id="424465at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033746">
        <property type="term" value="F:histone H3R2 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033749">
        <property type="term" value="F:histone H4R3 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035515">
        <property type="term" value="F:oxidative RNA demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106140">
        <property type="term" value="F:P-TEFb complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070815">
        <property type="term" value="F:peptidyl-lysine 5-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140537">
        <property type="term" value="F:transcription regulator activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048821">
        <property type="term" value="P:erythrocyte development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007507">
        <property type="term" value="P:heart development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001822">
        <property type="term" value="P:kidney development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030324">
        <property type="term" value="P:lung development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042116">
        <property type="term" value="P:macrophage activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140694">
        <property type="term" value="P:membraneless organelle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032463">
        <property type="term" value="P:negative regulation of protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035513">
        <property type="term" value="P:oxidative RNA demethylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043654">
        <property type="term" value="P:recognition of apoptotic cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060041">
        <property type="term" value="P:retina development in camera-type eye"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002040">
        <property type="term" value="P:sprouting angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033077">
        <property type="term" value="P:T cell differentiation in thymus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.270:FF:000001">
        <property type="entry name" value="Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.650:FF:000010">
        <property type="entry name" value="bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050910">
        <property type="entry name" value="JMJD6_ArgDemeth/LysHydrox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480">
        <property type="entry name" value="ARGININE DEMETHYLASE AND LYSYL-HYDROXYLASE JMJD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480:SF32">
        <property type="entry name" value="BIFUNCTIONAL ARGININE DEMETHYLASE AND LYSYL-HYDROXYLASE JMJD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="JmjC" evidence="17">
        <location>
            <begin position="141"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="336"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="340"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="394"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005026612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="414" mass="47790" checksum="EB7391B3360C345D" modified="2022-01-19" version="1">MNHKSKKRIREAKRSARPELKDSLDWTRHNYCETFPLSPAACKDNVERADALQLTVEEFVERYEKPYKPVVLLNAQVGWSAQEKWTLERLKRKYRNQKFKCGEDNDGYSVKMKMKYYIEYMETTRDDSPLYIFDSSYGEHPKRRKLLEDYKVPKFFTDDLFQYAGEKRRPPYRWFVMGPPRSGTGIHIDPLGTSAWNALVQGHKRWCLFPTSTPRELIKVTREEGGNQQDEAITWFNVIYPRTQLPTWPPEFKPLEILQKPGETVFVPGGWWHVVLNLDTTIAITQNFASCTNFPVVWHKTVRGRPKLSRKWYRILKQEHPDLAALADSVDLQESTGIASDSSSDSSSSSSSSSSDSDSECDSGSETEGMMHRRKKRRTCSMMGNGDTTSQDDCVSKERSSSRIRESCGGRSYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UG57</accession>
    <name>A0A8C2UG57_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Regulator of G-protein signaling 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">RGS1</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015725015.1">
        <property type="nucleotide sequence ID" value="XM_015869529.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UG57"/>
    <dbReference type="Ensembl" id="ENSCJPT00005036980.1">
        <property type="protein sequence ID" value="ENSCJPP00005027339.1"/>
        <property type="gene ID" value="ENSCJPG00005021208.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107317177"/>
    <dbReference type="KEGG" id="cjo:107317177"/>
    <dbReference type="CTD" id="5996"/>
    <dbReference type="GeneTree" id="ENSGT00940000157316"/>
    <dbReference type="OrthoDB" id="196547at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001965">
        <property type="term" value="F:G-protein alpha-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061737">
        <property type="term" value="P:leukotriene signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009617">
        <property type="term" value="P:response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd08715">
        <property type="entry name" value="RGS_RGS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.167.10:FF:000001">
        <property type="entry name" value="Putative regulator of g-protein signaling 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845:SF34">
        <property type="entry name" value="REGULATOR OF G-PROTEIN SIGNALING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01301">
        <property type="entry name" value="RGSPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RGS" evidence="8">
        <location>
            <begin position="75"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005027339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="199" mass="23012" checksum="A5CE644139374608" modified="2022-01-19" version="1">MPGLFFSHNNMTELNGKEDCKLAEGKIHKKKQKAFGADLKNYLRCMVPHLESGIKSSNTRNVMLSAEEVVQWSQSLEKLLASQSGQGVFREFLKSEFSEENIEFWLACEDYKKTKADHLHGKAERIYEEFVQSDAIKQINIDHQMREATAKKAQDPTHSSFDEAQRTVYILMERDSYPRFLKSKAYLNLLNQLQTNNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UG58</accession>
    <name>A0A8C2UG58_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CO040 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">C10H15orf40</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0235 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015728486.1">
        <property type="nucleotide sequence ID" value="XM_015873000.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UG58"/>
    <dbReference type="Ensembl" id="ENSCJPT00005035132.1">
        <property type="protein sequence ID" value="ENSCJPP00005025877.1"/>
        <property type="gene ID" value="ENSCJPG00005020220.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107318773"/>
    <dbReference type="KEGG" id="cjo:107318773"/>
    <dbReference type="CTD" id="103046828"/>
    <dbReference type="GeneTree" id="ENSGT00940000164795"/>
    <dbReference type="OrthoDB" id="244097at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1200.10">
        <property type="entry name" value="YggU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00634">
        <property type="entry name" value="UPF0235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003746">
        <property type="entry name" value="DUF167"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036591">
        <property type="entry name" value="YggU-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00251">
        <property type="entry name" value="DUF167 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13420">
        <property type="entry name" value="UPF0235 PROTEIN C15ORF40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13420:SF7">
        <property type="entry name" value="UPF0235 PROTEIN C15ORF40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02594">
        <property type="entry name" value="DUF167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01152">
        <property type="entry name" value="DUF167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69786">
        <property type="entry name" value="YggU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005025877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="146" mass="15089" checksum="08C53D34B2560252" modified="2022-01-19" version="1">MPFPEAMLGLAGFRQRLAVPLRNRGGAMPRKGKAAGKERDEPGAAAGPVVAAGDGGVRVSVRAKPGSRCSAVTDVTAEAVGVAIAAPPSEGEANAELCRYLSKVLEVKKSDVILEKGGKSRDKVVKILASVTPDEVLEKLKKEAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UGX0</accession>
    <name>A0A8C2UGX0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">KIF5C</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2UGX0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005036170.1">
        <property type="protein sequence ID" value="ENSCJPP00005026712.1"/>
        <property type="gene ID" value="ENSCJPG00005020706.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158539"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904115">
        <property type="term" value="C:axon cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044295">
        <property type="term" value="C:axonal growth cone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035253">
        <property type="term" value="C:ciliary rootlet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032839">
        <property type="term" value="C:dendrite cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098957">
        <property type="term" value="P:anterograde axonal transport of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098964">
        <property type="term" value="P:anterograde dendritic transport of messenger ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030951">
        <property type="term" value="P:establishment or maintenance of microtubule cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007292">
        <property type="term" value="P:female gamete generation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008045">
        <property type="term" value="P:motor neuron axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048489">
        <property type="term" value="P:synaptic vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF70">
        <property type="entry name" value="KINESIN HEAVY CHAIN ISOFORM 5C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="8">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="152"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="234"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="411"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005026712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="695" mass="79876" checksum="D62D410F4A7B6E20" modified="2025-10-08" version="2">MDVIDEGKANRHVAVTNMNEHSSRSHSIFLINIKQENVETEKKLSGKLYLVDLAGSEKVSKTGAEGAVLDEAKNINKSLSALGNVISALAEGTKTHVPYRDSKMTRILQDSLGGNCRTTIVICCSPSIFNEAETKSTLMFGQRAKTIKNTVCVNVELTAEQWKKKYEKEKEKNKSLKNVIQHLELELNRWRNGEAVPEDEQISAKDQKNLEPCDNTPIIDNITPVVASISTEEKQKYDEEIASLYRQLDDKDDEINQQSQLAEKLKQQMLDQEELLASTRRDYEKIQEELTRLQIENEAAKDEVKEVLQALEELAVNYDQKSQEVEDKTRANEQLADELAQKSTVLSATQRELGQLQELSNHQKKRATEILNLLLKDLGEIGGIIGTNDVKTLADVNGVIEEEFTMARLYISKMKSEVKSLVNRSKQLESAQIDSNRKMNASERELAACQLLISQHEAKIKSLTDYMQNMEQKRRQLEESQDSLNEELAKLRAQEKMHEVSFKDKEKEHLTRLQDAEEMKKALEQQMESHREAHQKQLSRLRDEIEEKQKTIDEIRDMNQKLQLEQEKLSADYDKLKIEDQEREMKLEKLILLNEKREQAREDLKGLEETVVSRVYKLLRLLASTRRDYEKIQEELTRLQIENEAAKDEVKEVLQALEELAVNYDQKSQEVEDKTRANEQLADELAQKSVRAGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y4K9</accession>
    <name>A0A8C2Y4K9_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="19">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">PPP1CC</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18 19">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Chromosome</location>
            <location evidence="5">Centromere</location>
            <location evidence="5">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cleavage furrow</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Midbody</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PPP phosphatase family. PP-1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="19"/>
    <dbReference type="RefSeq" id="XP_015733321.1">
        <property type="nucleotide sequence ID" value="XM_015877835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y4K9"/>
    <dbReference type="SMR" id="A0A8C2Y4K9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005000082.1">
        <property type="protein sequence ID" value="ENSCJPP00005000036.1"/>
        <property type="gene ID" value="ENSCJPG00005000071.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107321188"/>
    <dbReference type="KEGG" id="cjo:107321188"/>
    <dbReference type="CTD" id="5501"/>
    <dbReference type="GeneTree" id="ENSGT00940000153472"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032154">
        <property type="term" value="C:cleavage furrow"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072357">
        <property type="term" value="C:PTW/PP1 phosphatase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0032922">
        <property type="term" value="P:circadian regulation of gene expression"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:entrainment of circadian clock by photoperiod"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:glycogen metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="MPP_PP1_PPKL"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
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    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF300">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="16" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9" id="KW-0132">Cell division</keyword>
    <keyword evidence="8" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="11 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="21">
        <location>
            <begin position="121"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
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            <dbReference type="ARBA" id="ARBA00023277"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005000036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="323" mass="37000" checksum="5A6C112C16898615" modified="2022-01-19" version="1">MADIDKLNIDSIIQRLLEVRGSKPGKNVQLQENEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVLGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPAEKKKPNASRPVTPPRSMITKQAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y6P8</accession>
    <name>A0A8C2Y6P8_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">N-alpha-acetyltransferase 38, NatC auxiliary subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">NAA38</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y6P8"/>
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        <property type="protein sequence ID" value="ENSCJPP00005003950.1"/>
        <property type="gene ID" value="ENSCJPG00005004021.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000018418"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
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        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd06168">
        <property type="entry name" value="LSMD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000028">
        <property type="entry name" value="N-alpha-acetyltransferase 38, NatC auxiliary subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034110">
        <property type="entry name" value="LSMD1_Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
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        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050914">
        <property type="entry name" value="snRNP_SmB/NAA38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701:SF5">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 38, NATC AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B AND N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sm" evidence="3">
        <location>
            <begin position="30"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="11"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005003950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="114" mass="12056" checksum="0825DE1992DA45A8" modified="2022-01-19" version="1">MPGARHFRRIAVRSHGGTGGEREGGEGGSPHARRLAALLNRSLRVRMSDGRTLVGTFLCTDRDANIILGSAQEFLKAADAFPGSEPRVLGLAMVPGHHIVSIEVERDAAAALCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y7S3</accession>
    <name>A0A8C2Y7S3_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FA complementation group G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FANCG</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015703809.1">
        <property type="nucleotide sequence ID" value="XM_015848323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y7S3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005009926.1">
        <property type="protein sequence ID" value="ENSCJPP00005006287.1"/>
        <property type="gene ID" value="ENSCJPG00005005903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107305783"/>
    <dbReference type="KEGG" id="cjo:107305783"/>
    <dbReference type="CTD" id="2189"/>
    <dbReference type="GeneTree" id="ENSGT00390000007195"/>
    <dbReference type="OrthoDB" id="6355951at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome Z"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043240">
        <property type="term" value="C:Fanconi anaemia nuclear complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001541">
        <property type="term" value="P:ovarian follicle development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009314">
        <property type="term" value="P:response to radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007286">
        <property type="term" value="P:spermatid development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039684">
        <property type="entry name" value="FANCG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15254:SF2">
        <property type="entry name" value="FANCONI ANEMIA GROUP G PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15254">
        <property type="entry name" value="FANCONI ANEMIA GROUP G PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="532"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="643" mass="71399" checksum="307802692C3F3A7A" modified="2022-01-19" version="1">MKRLRRGAAPEPGCLQAWAAQCEALAGRWREARGSACGGEVARQLRGAFGELLLRMQGLPPALPTMPLELTVLYNSLLFVLGTSDCAIKGEAEGIRHGLLRVLEACGTCGQDLSTEELWQKVLQEVTVEELQSPLHRLAALQAAWWLAASCLQSITDLFRLLSRSEDPGRTPCSGEKNELLALLKAWRAPAEEASISLVQSTEELKETLCTAAAFLQGLQELEAGNLSTTLCLLQEAAGGFCSKRVLALIYVCLGCCAQRMCKPQTALQHLKRALQVDFQCHSALLHTAAVYQELGETDAELQALSLLYEALERNPPSATSSCPYFLIRVELLVNAPILVSLLRHRQPSEVKYLLAQRCLQDGRVADAVEHYLDFLALLQEGLQQQVPLDGDSLLPRIPEVFLEAASALEQGGRHQDSLAVCDEVISRTTNLIPQIVQIEEKLERPECASLEAGLAGGLPSQKRESLCCLMWRAAAYLHQGWVWTKLGKGKEALMQFSRCLNELLRFQPCGRGVEPAESLLPEVKVLQKIRLLSLIGRGMQFLEQERHKEALLDFQHGLQISPDDPTAAFYLVQVLWKLNRKQEASDYWQKYSESPAVEDRQQERPFPLYLDSCLKQAALPQDGSLVRCIQDYLRTTRQDSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y9K3</accession>
    <name>A0A8C2Y9K3_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y9K3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005014943.1">
        <property type="protein sequence ID" value="ENSCJPP00005010045.1"/>
        <property type="gene ID" value="ENSCJPG00005008791.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000239112"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051051">
        <property type="entry name" value="E3_ubiq-ligase_TRIM/RNF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25465">
        <property type="entry name" value="B-BOX DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25465:SF77">
        <property type="entry name" value="E3 UBIQUITIN_ISG15 LIGASE TRIM25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="20"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005010045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="73" mass="7989" checksum="8DD4348F360E4AB5" modified="2022-01-19" version="1">MAKTKEEFGASSSLDDELSCSICLSTYRNPVSLCCGHSFCRQCIQKVLSAQRQDKAPYSFQHPQDGRVSGGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YCN6</accession>
    <name>A0A8C2YCN6_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Potassium channel tetramerization domain containing 17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">KCTD17</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YCN6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005023353.1">
        <property type="protein sequence ID" value="ENSCJPP00005016642.1"/>
        <property type="gene ID" value="ENSCJPG00005013655.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161746"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031463">
        <property type="term" value="C:Cul3-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990756">
        <property type="term" value="F:ubiquitin-like ligase-substrate adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032469">
        <property type="term" value="P:endoplasmic reticulum calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045724">
        <property type="term" value="P:positive regulation of cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18391">
        <property type="entry name" value="BTB_POZ_KCTD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2000:FF:000001">
        <property type="entry name" value="Potassium channel tetramerization domain-containing 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000005">
        <property type="entry name" value="Potassium channel tetramerization domain-containing 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14958:SF24">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14958">
        <property type="entry name" value="POTASSIUM CHANNEL TETRAMERISATION DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="31"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005016642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="297" mass="33553" checksum="29717D4C7F92D818" modified="2022-01-19" version="1">MRMWMEGGEEMKGAMGLRCGWDPPPIDAQAKWVRLNVGGTVFLTTRQTLCREQKSFLCRLCQGEELQSDRDETGAYLIDRDPTYFGPILNFLRHGKLVLDKDMAEEGVLEEAEFYNIGPLIRIIKDRLEEKDYTVTQVPPKHVYRVLQCQEEELTQMVSTMSDGWRFEQLVNIGSCYSYGNEDQTEFLCVVSKELYNSSNGLSSESSHKAKTVHVPDTPSCSPLSPSLHCHLPGAPYPIPQSPTFFSLLSLPLMASFQQTWFLSPLPNPRFCVFPAQGPISLCSSLFLLCSCYKPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YD51</accession>
    <name>A0A8C2YD51_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dedicator of cytokinesis 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">DOCK7</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DOCK family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSCJPT00005024646.1">
        <property type="protein sequence ID" value="ENSCJPP00005017674.1"/>
        <property type="gene ID" value="ENSCJPG00005012616.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155661"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007409">
        <property type="term" value="P:axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045200">
        <property type="term" value="P:establishment of neuroblast polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904754">
        <property type="term" value="P:positive regulation of vascular associated smooth muscle cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016601">
        <property type="term" value="P:Rac protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd08696">
        <property type="entry name" value="C2_Dock-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11703">
        <property type="entry name" value="DHR2_DOCK7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.740:FF:000002">
        <property type="entry name" value="Dedicator of cytokinesis protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.410:FF:000002">
        <property type="entry name" value="Dedicator of cytokinesis protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000022">
        <property type="entry name" value="Dedicator of cytokinesis protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037808">
        <property type="entry name" value="C2_Dock-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027007">
        <property type="entry name" value="C2_DOCK-type_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026791">
        <property type="entry name" value="DOCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021816">
        <property type="entry name" value="DOCK_C/D_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043161">
        <property type="entry name" value="DOCK_C_lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043162">
        <property type="entry name" value="DOCK_C_lobe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027357">
        <property type="entry name" value="DOCKER_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046769">
        <property type="entry name" value="DOCKER_Lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046770">
        <property type="entry name" value="DOCKER_Lobe_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046773">
        <property type="entry name" value="DOCKER_Lobe_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23317">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23317:SF78">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06920">
        <property type="entry name" value="DHR-2_Lobe_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20422">
        <property type="entry name" value="DHR-2_Lobe_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20421">
        <property type="entry name" value="DHR-2_Lobe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14429">
        <property type="entry name" value="DOCK-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11878">
        <property type="entry name" value="DOCK_C-D_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51650">
        <property type="entry name" value="C2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51651">
        <property type="entry name" value="DOCKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2 DOCK-type" evidence="5">
        <location>
            <begin position="594"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="domain" description="DOCKER" evidence="6">
        <location>
            <begin position="1705"/>
            <end position="2139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="170"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="921"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="201"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="921"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="976"/>
            <end position="998"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005017674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="2165" mass="245153" checksum="26BC2396359747A7" modified="2022-01-19" version="1">RSRRAPPQPRPVRLKAGAKAACVAHVICCLHCNSFAEITFSVSYFRTVAAEVRKQISGQYGGSPQLLKNLNIGGSVSHHTTVPLTEAVDPIDLEDYLNTHPITVESGPLRDLLEFPPDDIEVVYTPRECRTLVSAVPEESEMDPHVRDCVRSYTEDWAIVNRKYHKLGTGFNPNTLDKQKERQKGLPKQVFESDEAPDGNSYHDEQDDLKRRSMSIDDTPRGSWACSIFDLKNSLPDALLPNLLDRTPNEEIDHHNEDQRKSNRHKELFALHPAPDEEEPIERLSIPEVPKEHFGQRLLVKCLSLKFEIEIEPIFASLALYDVKEKKKISENFYFDLNSEQMKGMLRPHVPPAAISTLARSAIFSITYPSQDVFLVIKLEKVLQQGDIGECAEPYMIFKESDAAKNKEKLEKLKCQAEQFCQRLGKYRMPFAWTAIHLMNIVSSAGSLERDSTEVEVGTGERKGSWSERRNSSIVGRRSLERTTSGDEACNLTSFRPATLTVTNFFKQEGDRLSDEDLYKFLADMRRPSSVLRRLRPITAQLKIDISPAPENPHYCLTPELLQVKLYPDSRVRPTREILEFPARDVYVPNTTYRNLLYVYPQSLNFANRQGSARNITVKVQFMYGEDPSNAMPVIFGKSSCPEFSKEAYTAVVYHNRSPDFHEEIKIKLPATLTDHHHLLFTFYHVSCQQKQNTPLETPVGYTWIPMLQNGRLKTGQFCLPVSLEKPPQAYSVLSPEVPLPGMKWVDNHKGVFNVEVVAVSSLHTQDPYLDKFFALVHALDEHMFPVRIGDMRIMENNLENELKSSISALNSSQLEPVVRFLHLLLDKLILLVVRPPVIAGQIVNLGQASFEAMASIINRLHKNLDGNQDQHGRNSLLASYIYYVFRLPNTYPNSPSPGPGGLGGSVHYATMARSAVRPASLNLNRSRSLSNSNPDISGTPTSPDDEVRSIIGSKGLDRSNSWVNTGGPKAAPWGSNPSPSAESTQATDRSCNRMSSHTETSSFLQTLTGRLPTKKVDFTWTNSGFASWVVCSGSVREAALQQAWFFFELMVKSMVHHLYFADKLDASRKNRFPERFMDDVNALVSTIAGDIVSRFQKDTEMVERLNTSLAFFLNDLLSVMDRGFVFGLIKTCYKQVSSKLYSLTNPSNLVSLRLDFLRIICSHEHYVTLNLPCSLLTPPASPSPSVSSATSQSSGFSTNVQDQKIANMFELSVPFRQQHYLAGLVLTELAVILDPDAEGLFGLHKKVINMVHNLLSSHDSDPRYADPQVKARVAMLYLPLIGVIMETVPQLYDFTESHNQRGRPSCVTADDYEGESGSMISQTVAMAIAGTSVPQLTRPSSFLLTSSSGRQHSTFSTESSRSLLICLLWVLKNADESVLQKWFTDLSVLQLNRLLDLLYLCVSCFEYKGKKVFERMNSLTFKKSKDMRAKLEEAILGSIGARQEMVRRSRGQLERSPSGSAFGSQENLRWRKDMTHWRQNTEKLDKSRAEIEHEALIDGNLATEANLIILDTLEIVVQTVSVTESKESILGGVLKVLLHSMACNQSALYLQHCFATQRALVSKFPELLFEEETEQCADLCLRLLRHCSSSISTIRSHASASLYLLMRQNFEIGNNFARVKMQVTMSLSSLVGTSQNFNEEFLRRSLKTILTYAEEDLELRETTFPDQVQDLVFNLHMILSDTVKMKEHQEDPEMLIDLMYRIAKGYQNSPDLRLTWLQNMAGKHSERSNHAESAQCLVHSAALVAEYLSMLEDRKYLPVGCVTFQNISSNVLEESAVSDDVVSPDEEGICSGKYFTEAGLVGLLEQAAASFSMAGMYEAVNEVYKVLIPIHEANRDAKKLSTIHGKLQEAFSKIVHQDGKRMFGTYFRVGFYGTKFGDLDEQEFVYKEPAITKLAEISHRLEGFYGERFGEDVLEVIKDSNPVDKCKLDPNKAYIQITYVEPYFDTYEMKDRITYFDKNYNLRRFMYCTPFTLDGRAHGELHEQFKRKTILTTSHAFPYIKTRINVIHKEEIILTPIEVAIEDMQKKTQELAFATHQDPADPKMLQMVLQGSVGTTVNQGPLEVAQVFLSEIPNDPKLFRHHNKLRLCFKDFTKRCEDALRKNKSLIGPDQKEYQRELERNYHRLKEALQPLINRKIPQLYKAVLPVTCHRDSFSRMSLRKMDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YDL3</accession>
    <name>A0A8C2YDL3_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Pogo transposable element derived with ZNF domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">POGZ</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May function as a transcription factor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015740170.1">
        <property type="nucleotide sequence ID" value="XM_015884684.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005026101.1">
        <property type="protein sequence ID" value="ENSCJPP00005018825.1"/>
        <property type="gene ID" value="ENSCJPG00005015292.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107324568"/>
    <dbReference type="KEGG" id="cjo:107324568"/>
    <dbReference type="CTD" id="23126"/>
    <dbReference type="GeneTree" id="ENSGT00940000160649"/>
    <dbReference type="OrthoDB" id="5876240at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000298">
        <property type="entry name" value="zinc finger protein 280D isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059074">
        <property type="entry name" value="zf-C2H2_Z280C_D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057618">
        <property type="entry name" value="Znf_POGZ/Z280C-D-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF45">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT DERIVED WITH ZNF DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25414">
        <property type="entry name" value="zf-C2H2_Z280C_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25429">
        <property type="entry name" value="zf-POGZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="435"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="471"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="HTH CENPB-type" evidence="17">
        <location>
            <begin position="924"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="186"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="267"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="355"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="634"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="1245"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="186"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="216"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="287"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="378"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005018825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1321" mass="147641" checksum="DEA82AF41042E3FD" modified="2022-01-19" version="1">MADTDLFMECEEEELEPWQKISDVIEDSVVEDYNSVDKTTTAGNPLVQQGGQPLILTQNPTSGLGTMVTQPVLRPVQIMQNANHVTNSPVTSQPIFITTQGFPVRNVRPVQNTMNQVGIVLNVQQGQTVRPITLVPAPGTQFVKPAVGVPQVFSQVAQVRPGTTMPVRPTTNTFTTVIPATLTIRSTVPQSQSQQQSKSTPSTSTTPTATQPTPLGQLTVQQPGQSSQATNPKLVSIASFVTVKRPGVTGENSNEVAKLVNTLNTVPSLGQSPGPMVVSNSSPVHGSQRSSTSESSSSSKVSSSPIPTFDLQDGGRKVCPRCDAQFRVTEALRGHMCYCCPEMVEFLKKRKSLDSEPNIQSAKPPSPEKNTAVASPPSSTPIPALSPPAKAPEPSEGVVDSSQSKLIMLVDDFYYGRDGGKVSQLLNFPKVPTSFRCPHCTKRLKNNIRFMNHMKHHVELDQQNGEVDVHTICQHCYRQFSTPFQLQCHLENVHSPYESTTKCKICEWAFENEPMFLQHMKDTHKPGEMPYVCQVCQYRSSLYSEVDSHFRMIHEDTRHLLCPYCLKVFKNGNAFQQHFMRHQKKSVYHCNKCRLQFLFAKDKIEHKLQHHKTFRKPKQLEGLKPGTKVTIRASRGQPRTVPISSNDMGQGAGQDTAPLSSSDPQPIFLYPPVQRSVQKRAVKKMSVLGRQTCLECSFEIPDFPNHFPTYVHCSLCRYSTCCSRAYANHMINNHVPRKSPKYLALFKNYTACGVKLCCSSCLFASSEGDVMAKHLVFNPSHEFSNIVFRGPTWISHSRHIQPQDRSMKNTCPAYSPSKAATVKTKSVLPAKDDLEPEVALAAHTQPLLCQEEECLNIDAQEDEQPMKETEPASKKEQLSVKKLRVVLFALCYSTEQAAEHFRNPQRRIKRWLRRFQAFQEENLASLSEGKYLSLEAEEKLAEWVLTQREQQLPVNEETLFQKATKLGRSLEGGFKISYEWAVRFMLRHNLSMHTRRAVAHSLPKEVEDNAGCFIEFVQRQIHTQDLPLSMIAAIDEISLFLDVEVLSSDDKKENALQTVGTGEPWCDVVLTILADGSVLPTLVFYRGHVQQPANVPESIILEAKENGYSDDEVMELWASRVWQKHTECQNSKGMLVLDCHRTHLSEEVLSLLSASSTLPAVVPAGCSSKIQPLDVCIKRTVKNFLHKKWKEQAKEMADSTCDSDILLQLVLCWLAEVLEVISDSPELVQQSFLVASVLPGPDGTANSATRNADMQEELISTLEEQLKLGEEQQLQEAVEGEEQPQNEECGDPEILHQLFEGESETESFYGFEDADLDLMEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YDP8</accession>
    <name>A0A8C2YDP8_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Leucine-rich repeat-containing G-protein coupled receptor 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">LGR4</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015718928.1">
        <property type="nucleotide sequence ID" value="XM_015863442.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YDP8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005026145.1">
        <property type="protein sequence ID" value="ENSCJPP00005018862.1"/>
        <property type="gene ID" value="ENSCJPG00005015311.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107314315"/>
    <dbReference type="KEGG" id="cjo:107314315"/>
    <dbReference type="CTD" id="55366"/>
    <dbReference type="GeneTree" id="ENSGT00940000157925"/>
    <dbReference type="OrthoDB" id="1883493at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016500">
        <property type="term" value="F:protein-hormone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030282">
        <property type="term" value="P:bone mineralization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046849">
        <property type="term" value="P:bone remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032922">
        <property type="term" value="P:circadian regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048565">
        <property type="term" value="P:digestive tract development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001013">
        <property type="term" value="P:epithelial cell proliferation involved in renal tubule morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036335">
        <property type="term" value="P:intestinal stem cell homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030539">
        <property type="term" value="P:male genitalia development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072224">
        <property type="term" value="P:metanephric glomerulus development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072282">
        <property type="term" value="P:metanephric nephron tubule morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120163">
        <property type="term" value="P:negative regulation of cold-induced thermogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001818">
        <property type="term" value="P:negative regulation of cytokine production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034122">
        <property type="term" value="P:negative regulation of toll-like receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001649">
        <property type="term" value="P:osteoblast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090190">
        <property type="term" value="P:positive regulation of branching involved in ureteric bud morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090263">
        <property type="term" value="P:positive regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd15361">
        <property type="entry name" value="7tmA_LGR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000028">
        <property type="entry name" value="leucine-rich repeat-containing G-protein coupled receptor 4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000028">
        <property type="entry name" value="leucine-rich repeat-containing G-protein coupled receptor 4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002131">
        <property type="entry name" value="Gphrmn_rcpt_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000372">
        <property type="entry name" value="LRRNT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372">
        <property type="entry name" value="GLYCOPROTEIN HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372:SF67">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING G-PROTEIN COUPLED RECEPTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01462">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00373">
        <property type="entry name" value="GLYCHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SMART" id="SM00013">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="10" id="KW-0221">Differentiation</keyword>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="14 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0675">Receptor</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 22" id="KW-0732">Signal</keyword>
    <keyword evidence="18" id="KW-0807">Transducer</keyword>
    <keyword evidence="7 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="signal peptide" evidence="22">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034911945" description="Leucine-rich repeat-containing G-protein coupled receptor 4" evidence="22">
        <location>
            <begin position="19"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="538"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="575"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="619"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="661"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="702"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="748"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="783"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="23">
        <location>
            <begin position="554"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="487"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00039745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005018862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="950" mass="104646" checksum="728EA8FDE921AE89" modified="2022-01-19" version="1">MRCLALLGLVAWGLGSSAGPSGGASPPPCPASCSCDGDRGVDCSGRGLAAVPPGLSAFTHALDVSMNNITRLPEDAFKNFPYLEELRLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTVPNEAIRGLSGLQSLRLDANHITAVPKDSFEGLVQLRHLWLDDNSLTEVPIHPLSNLPSLQALTLALNKITHIPDYAFTNLSSLVVLHLHNNKIKTIGKHCFDGLDNLETLDLNYNNMVEFPEAIKALPNLKELAFHSNYISIIPDGAFAGNPLLRTIHLYDNPLSFVGNSAFQNLSDLHSLVIRGASMVQWFPNLTGTVNLESLTLTGTKINSIPVNLCQEQKMLRTLDLSYNNIKDLPSFTGCHSLEEISLQHNQIHEITDDTFQGLSSLRILDLSRNRIHKIHKEAFTTIGAIVNLDLSFNELTSVPTEGLSGLNQLKLAGNSELKEALAAKNFAKLRSLSVPYAYQCCAFWGCDSYLNSNAEDSSHQDQDAKGDREKTDADGVRNEENVELGQTIIHCTPATGAFKPCEYLLGSWMIRLTVWFIFLVALFFNLLVILTVFASCAPLPSSKLFIGLISVSNLFMGVYTGILTFLDAVSWGRFAEFGIWWETGSGCRVTGFLAVFSSESAIFFLMLAAVERSFSAKEIIKKGKSNRQKQFQIAAVLAFLCAVVAGCLPLFHKAEYSASPLCLPFPTGETPSLGFTVTLVLLNSLAFLLMAIIYTKLYCNLEKEDLSENSQSSMIKHVAWLIFTNCIFFCPVAFFSFAPLITAISISPEIMKSVTLIFFPLPACLNPVLYVFFNPKFKEDWKLLRRRVTRKNRAVAISISAQGGCATQDFYYDCGMYTHLQGNIAVCECCESLLLSKPVPCKHLIKSHSCPTLAVVPCQRPDGYWSDCGTQSAHSDYADEDDSFVSDSSDQVQACGRACFYQSRGFPLVRYAYNIPRIKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YEV0</accession>
    <name>A0A8C2YEV0_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1 open reading frame 94</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">C23H1orf94</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015738742.1">
        <property type="nucleotide sequence ID" value="XM_015883256.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YEV0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005029380.1">
        <property type="protein sequence ID" value="ENSCJPP00005021396.1"/>
        <property type="gene ID" value="ENSCJPG00005017112.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107323834"/>
    <dbReference type="KEGG" id="cjo:107323834"/>
    <dbReference type="CTD" id="101945392"/>
    <dbReference type="GeneTree" id="ENSGT00390000017672"/>
    <dbReference type="OrthoDB" id="9948768at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031496">
        <property type="entry name" value="DUF4688"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35674">
        <property type="entry name" value="CDNA SEQUENCE CK137956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35674:SF1">
        <property type="entry name" value="CDNA SEQUENCE CK137956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15752">
        <property type="entry name" value="DUF4688"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005021396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="398" mass="43650" checksum="DF24CC796D5B369A" modified="2022-01-19" version="1">MLTSINGFAAPAVKSEGPFPLGPYPRHIWIHDNTPQDGLDKACHEIWKRMQSPPEELQPIICMDPQGPPWSKNGAHSGDWLLDETEGLESIYRAVIGNREREMKLRALCDAQLSAKSTITNLLRSTSSPRISKGLGDNSTTGAGSTEGNKLGMPLLLKHTDIAKGPDRQLMAEESKTMKEFFQNGTVSAAKNSTAVPALMAESQTAGQKQQLPTLAKICSRPDSNAATKALQNPVTTAALDKKIVIYNASTSNPHFPVTTTTTNLNQPMWPSLSFPPLPLYPNQPNYPPFQGPYQRARIPFQQPLHPSYGCYTRQGAPYSPQMYRSPYTPMLNYIPLVQPGFPHQRAPAQLPTSIQDLPAARDGMRFTFPPPYGFAAVPGGAVRPTHHYPPNANCVNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YFA7</accession>
    <name>A0A8C2YFA7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">rRNA methyltransferase 1, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">MRM1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2YFA7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005030548.1">
        <property type="protein sequence ID" value="ENSCJPP00005022261.1"/>
        <property type="gene ID" value="ENSCJPG00005017778.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000018761"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070039">
        <property type="term" value="F:rRNA (guanosine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd18105">
        <property type="entry name" value="SpoU-like_MRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047182">
        <property type="entry name" value="MRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047261">
        <property type="entry name" value="MRM1_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46103">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46103:SF1">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08032">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00967">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="RNA 2-O ribose methyltransferase substrate binding" evidence="10">
        <location>
            <begin position="55"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005022261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="365" mass="39822" checksum="0A5A6CF791758A35" modified="2025-10-08" version="2">MALLPPSARSCCFGVGPTRDQQPTRLYTAREGSKGRSRPQGRRVLPIERTRGSEILFGVAPCSMALSQARRDLFRLFLKQSVGPQRLVSSELVLQAAARGVPVLHVGRRELDELCGGRVHQGVCLEATPLRYKRMEEDEGSDGESTNRQLLWLVLEQIQDPMNLGALLRSAYFLGVDRVVTSRRNSCPLTPTVSKASSGAMEVFDVYSTDDLRSFLKAKAAEGWEVVGTVSQSETVENVPVISCLEFRWNKPIILVIGSEGDGLSLETQLLCHQMLLIPSGRTLHPGIESLNVSVATGILLHSICSQKLRKGKGLGRLLARCHHDVNCAAVSDPAEGARAPDLLISRKPDAVFGVSRVLPLQQQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YGQ0</accession>
    <name>A0A8C2YGQ0_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytoskeleton associated protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">CKAP2</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CKAP2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015707361.1">
        <property type="nucleotide sequence ID" value="XM_015851875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YGQ0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005034328.1">
        <property type="protein sequence ID" value="ENSCJPP00005025215.1"/>
        <property type="gene ID" value="ENSCJPG00005019815.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107308187"/>
    <dbReference type="KEGG" id="cjo:107308187"/>
    <dbReference type="CTD" id="26586"/>
    <dbReference type="GeneTree" id="ENSGT00530000063691"/>
    <dbReference type="OrthoDB" id="9945093at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007026">
        <property type="term" value="P:negative regulation of microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029197">
        <property type="entry name" value="CKAP2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026165">
        <property type="entry name" value="CKAP2_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16076">
        <property type="entry name" value="CYTOSKELETON ASSOCIATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16076:SF8">
        <property type="entry name" value="CYTOSKELETON-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15297">
        <property type="entry name" value="CKAP2_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytoskeleton-associated protein 2 C-terminal" evidence="7">
        <location>
            <begin position="329"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="Cytoskeleton-associated protein 2 C-terminal" evidence="7">
        <location>
            <begin position="558"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="517"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="645"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="517"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="557"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="574"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="586"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="645"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF15297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005025215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="688" mass="76982" checksum="F2B1057CDDF78574" modified="2022-01-19" version="1">MAARLPPQLHSSRRSDPTYREQRRQKVEEYLSRKKTFSGMPIHDNEASISSRTRKATSNKLQDKTKLSASPKPEMEDKENANELSWDQSSRTSEENIILKSSTVTLASEMDPEVCASVNKGNEIKSERVLLSKSLQVKTIKEKQLTAEKHSSNVSLPRKPVLGTYRGRVIQSKINSFRKAPKSEGEKSSVSDEKLLTSATKPAVKSLSRGSCNVVLKTVKVTNYPNSAKPNCVLPLQSKQSAKPAINSQSSLNKQPSTSAVVPRKLTVQKTIGKRGPQQPRGASMNSDHGTLGVKKCEDLCKDGKPEAPAKRFSVFPSGKVGQDYKANNIKKSLFPRESAEERRVRLAEWRASRGKVMKRPPTSVLLGTQPKNEEQELAYTGGSLNHELNSEKVNKTLTECLQLAEQGCQGNKARAMLEELIGSIPGAKKLAKYWICWMRLEQMGPPEKLVAGYEEAILAGAMPRDELRRMLIDAIRNTENLVKSEDGGAVMETHLSEVVEISKELNSSVEQVHEAFKDLNVDDQKAENDDKKEETGNEMVKKEPDLVFKPEEILPKKNKKHKNRERRKKGKCERKEQSEDKVKDTAQTVNSPEKNNDTGSLMSCNPSTNPCLESVKMHYGGDDSDLKMITPLRYSLRIREKMYKYSDTPRDSHVSSSEQLQELESKATALIHEQNDKLEEASAEVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YH49</accession>
    <name>A0A8C2YH49_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Synaptic vesicle glycoprotein 2B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">SV2B</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Secretory vesicle</location>
            <location evidence="1">Synaptic vesicle membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015728640.1">
        <property type="nucleotide sequence ID" value="XM_015873154.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015728641.1">
        <property type="nucleotide sequence ID" value="XM_015873155.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015728642.1">
        <property type="nucleotide sequence ID" value="XM_015873156.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032302754.1">
        <property type="nucleotide sequence ID" value="XM_032446863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YH49"/>
    <dbReference type="Ensembl" id="ENSCJPT00005035457.1">
        <property type="protein sequence ID" value="ENSCJPP00005026152.1"/>
        <property type="gene ID" value="ENSCJPG00005020404.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005035458.1">
        <property type="protein sequence ID" value="ENSCJPP00005026153.1"/>
        <property type="gene ID" value="ENSCJPG00005020404.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107318858"/>
    <dbReference type="KEGG" id="cjo:107318858"/>
    <dbReference type="CTD" id="9899"/>
    <dbReference type="GeneTree" id="ENSGT00950000182940"/>
    <dbReference type="OrthoDB" id="433512at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006836">
        <property type="term" value="P:neurotransmitter transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099509">
        <property type="term" value="P:regulation of presynaptic cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000300">
        <property type="term" value="P:regulation of synaptic vesicle exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000009">
        <property type="entry name" value="Synaptic vesicle glycoprotein 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000014">
        <property type="entry name" value="synaptic vesicle glycoprotein 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.80:FF:000001">
        <property type="entry name" value="Synaptic vesicle glycoprotein 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.80">
        <property type="entry name" value="E3 ubiquitin-protein ligase SopA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055415">
        <property type="entry name" value="LD_SV2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022308">
        <property type="entry name" value="SV2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01299">
        <property type="entry name" value="synapt_SV2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF2">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23894">
        <property type="entry name" value="LD_SV2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141571">
        <property type="entry name" value="Pentapeptide repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0532">Neurotransmitter transport</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0770">Synapse</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="222"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="558"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="588"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="614"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="647"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="676"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="14">
        <location>
            <begin position="133"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005026152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="705" mass="80376" checksum="91F33E790D1A7CA8" modified="2022-01-19" version="1">MDDGYRNTNLYQGGRETNQVSDDYRYQDGNYEGYAPNDGYYRGGDEPTHEEDAQSDVTEGHDEDDEVYEGEYQGIPHPDDIKAKQKNRAPAMDDEYRDRADLMAERMEDEEQLAHQYENIIEECGHGRFQWTLFFVLGLALMADGVELFVVGFVLPSAEKDMCLSSSNKGMLGLIVYLGMMVGAVMLGGLADKLGRKKCLIISLAINAAFAFLSSFVQGYGFFLFCRLISGLGIGGSLPIVFAYFSEFLSREKRGEHLSWLCMFWMIGGIFASAMAWSIIPHYGWGFSMGTKYHFHSWRVFVLVCSLPCIASLVALKFMPESPRFLLEMGKHDEAWMILKQVHDTNMRAKGEPERVFTVSYIKTPKQVDEFIEIQSSTGTWYQRWLVRITTVFKQVWDNVLYCLTAQYRMNTLMLAVVWFTMALSYYGLIVWFPDMIRYFQEEAYESRVKVFDEEEVSHFTFNFTLENQIHRNGEYRNDKFIGMKFKEVRFEDSLFEECYFEDVTSSETFFENCTIISTVFYNTDLYEHKFINCRLINTTFMKEKEGCHIDFEEDNDFLIYLVSFLGSLSVLPGNIISALLMDKIGRIKMIGGSMLISAVCCFFLFFGNSESAMIGWQCLFCGASIAAWNALDVITVELYPTDKRATAFGILNGLCKFGAILGNSIFASFVGITKVVPILLASSALVGGGLLALRLPETRDQVLM</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1996-10-01" modified="2026-01-28" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>P50681</accession>
    <accession>Q8SEW9</accession>
    <name>ATP6_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP synthase F(0) complex subunit a</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>F-ATPase protein 6</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Proton-conducting channel, ATP synthase F(0) complex subunit a</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">MT-ATP6</name>
        <name type="synonym">ATP6</name>
        <name type="synonym">ATPASE6</name>
        <name type="synonym">MTATP6</name>
    </gene>
    <organism>
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <geneLocation type="mitochondrion"/>
    <reference key="1">
        <citation type="journal article" date="2001" name="Anim. Genet." volume="32" first="380" last="385">
            <title>Complete sequence of the Japanese quail (Coturnix japonica) mitochondrial genome and its genetic relationship with related species.</title>
            <authorList>
                <person name="Nishibori M."/>
                <person name="Hayashi T."/>
                <person name="Tsudzuki M."/>
                <person name="Yamamoto Y."/>
                <person name="Yasue H."/>
            </authorList>
            <dbReference type="PubMed" id="11736810"/>
            <dbReference type="DOI" id="10.1046/j.1365-2052.2001.00795.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <tissue>Blood</tissue>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="1995-09" db="EMBL/GenBank/DDBJ databases">
            <title>Nucleotide sequence of mitochondrial genes for COI, tRNAs Lys, Asp, Ser (UCN), COII and ATPases 8 and 6 of the quail Coturnix japonica.</title>
            <authorList>
                <person name="Ramirez V."/>
                <person name="Morais R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-22</scope>
        <source>
            <tissue>Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Subunit a, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. With the subunit c (ATP5MC1), forms the proton-conducting channel in the F(0) domain, that contains two crucial half-channels (inlet and outlet) that facilitate proton movement from the mitochondrial intermembrane space (IMS) into the matrix. Protons are taken up via the inlet half-channel and released through the outlet half-channel, following a Grotthuss mechanism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+)(in) = H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:34979"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the ATP synthase complex composed at least of ATP5F1A/subunit alpha, ATP5F1B/subunit beta, ATP5MC1/subunit c (homooctamer), MT-ATP6/subunit a, MT-ATP8/subunit 8, ATP5ME/subunit e, ATP5MF/subunit f, ATP5MG/subunit g, ATP5MK/subunit k, ATP5MJ/subunit j, ATP5F1C/subunit gamma, ATP5F1D/subunit delta, ATP5F1E/subunit epsilon, ATP5PF/subunit F6, ATP5PB/subunit b, ATP5PD/subunit d, ATP5PO/subunit OSCP. ATP synthase complex consists of a soluble F(1) head domain (subunits alpha(3) and beta(3)) - the catalytic core - and a membrane F(0) domain - the membrane proton channel (subunits c, a, 8, e, f, g, k and j). These two domains are linked by a central stalk (subunits gamma, delta, and epsilon) rotating inside the F1 region and a stationary peripheral stalk (subunits F6, b, d, and OSCP). Interacts with DNAJC30; interaction is direct.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Mitochondrion inner membrane</location>
            <topology>Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ATPase A chain family.</text>
    </comment>
    <dbReference type="EMBL" id="AP003195">
        <property type="protein sequence ID" value="BAB62920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="U36794">
        <property type="protein sequence ID" value="AAA76732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_572019.1">
        <property type="nucleotide sequence ID" value="NC_003408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P50681"/>
    <dbReference type="SMR" id="P50681"/>
    <dbReference type="Ensembl" id="ENSCJPT00005000023.1">
        <property type="protein sequence ID" value="ENSCJPP00005000007.1"/>
        <property type="gene ID" value="ENSCJPG00005000023.1"/>
    </dbReference>
    <dbReference type="GeneID" id="804661"/>
    <dbReference type="KEGG" id="cjo:804661"/>
    <dbReference type="CTD" id="4508"/>
    <dbReference type="GeneTree" id="ENSGT00390000005568"/>
    <dbReference type="OrthoDB" id="5976622at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015252">
        <property type="term" value="F:proton channel activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042776">
        <property type="term" value="P:proton motive force-driven mitochondrial ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="CDD" id="cd00310">
        <property type="entry name" value="ATP-synt_Fo_a_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.220:FF:000004">
        <property type="entry name" value="ATP synthase subunit a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.220">
        <property type="entry name" value="ATP synthase, F0 complex, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000568">
        <property type="entry name" value="ATP_synth_F0_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023011">
        <property type="entry name" value="ATP_synth_F0_asu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045083">
        <property type="entry name" value="ATP_synth_F0_asu_bact/mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035908">
        <property type="entry name" value="F0_ATP_A_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01131">
        <property type="entry name" value="ATP_synt_6_or_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11410">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11410:SF0">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00119">
        <property type="entry name" value="ATP-synt_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00123">
        <property type="entry name" value="ATPASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81336">
        <property type="entry name" value="F1F0 ATP synthase subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00449">
        <property type="entry name" value="ATPASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0066">ATP synthesis</keyword>
    <keyword id="KW-0138">CF(0)</keyword>
    <keyword id="KW-0375">Hydrogen ion transport</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000082109" description="ATP synthase F(0) complex subunit a">
        <location>
            <begin position="1"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="227" mass="25026" checksum="66C9256FC8132F93" modified="2003-09-26" version="2">MNLSFFDQFSSPYLMGMPLILPSLLLPTLLFPTPGRRWISNRLSTLQLWVINLITKQLMTPLNKTGHKWALLLTSLILLLLSINLMGLLPYTFTPTTQLSMNMALAFPLWLATLLIGLRNQPSASLAHLLPEGTPTPLIPILIMIETTSLLIRPLALGVRLTANLTAGHLLIQLISTATIALLPTMPSISTLTALILLLLTILEVAVAMIQAYVFVLLLSLYLQENI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1997-11-01" modified="2025-02-05" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q90343</accession>
    <name>NR13_COTJA</name>
    <protein>
        <recommendedName>
            <fullName>Anti-apoptotic protein NR13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Apoptosis regulator Nr-13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">NR13</name>
    </gene>
    <organism>
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1995" name="EMBO J." volume="14" first="1372" last="1381">
            <title>A Bcl-2-related gene is activated in avian cells transformed by the Rous sarcoma virus.</title>
            <authorList>
                <person name="Gillet G"/>
                <person name="Guerin M"/>
                <person name="Trembleau A"/>
                <person name="Brun G"/>
            </authorList>
            <dbReference type="PubMed" id="7729415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>INDUCTION</scope>
        <source>
            <tissue>Fibroblast</tissue>
            <tissue>Neuroretina</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Shows anti-apoptotic properties. Counteract the pro-apoptotic activity of BAX.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with BAX.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Cell membrane</location>
            <topology>Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="tissue specificity">
        <text evidence="3">Mainly expressed in neural and muscular tissues.</text>
    </comment>
    <comment type="developmental stage">
        <text evidence="3">Expression is dramatically down-regulated after embryonic day 7 in the optic tectum, and correlates with the onset of apoptosis in this area.</text>
    </comment>
    <comment type="induction">
        <text evidence="3">By Rous sarcoma virus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Bcl-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="X84418">
        <property type="protein sequence ID" value="CAA59136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q90343"/>
    <dbReference type="SMR" id="Q90343"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051400">
        <property type="term" value="F:BH domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097192">
        <property type="term" value="P:extrinsic apoptotic signaling pathway in absence of ligand"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008630">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to DNA damage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001836">
        <property type="term" value="P:release of cytochrome c from mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.437.10:FF:000027">
        <property type="entry name" value="Anti-apoptotic protein NR13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.437.10">
        <property type="entry name" value="Blc2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036834">
        <property type="entry name" value="Bcl-2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046371">
        <property type="entry name" value="Bcl-2_BH1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026298">
        <property type="entry name" value="Bcl-2_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002475">
        <property type="entry name" value="Bcl2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020717">
        <property type="entry name" value="Bcl2_BH1_motif_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020726">
        <property type="entry name" value="Bcl2_BH2_motif_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11256">
        <property type="entry name" value="BCL-2 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11256:SF47">
        <property type="entry name" value="BCL-2-LIKE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00452">
        <property type="entry name" value="Bcl-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01862">
        <property type="entry name" value="BCL2FAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00337">
        <property type="entry name" value="BCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56854">
        <property type="entry name" value="Bcl-2 inhibitors of programmed cell death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50062">
        <property type="entry name" value="BCL2_FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01080">
        <property type="entry name" value="BH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01258">
        <property type="entry name" value="BH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0053">Apoptosis</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000143071" description="Anti-apoptotic protein NR13">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="BH1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="BH2">
        <location>
            <begin position="126"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="7729415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="177" mass="18826" checksum="AD5CE79D3353CC1F" modified="1996-11-01" version="1">MPGSLKEETALLLEDYFQHRAGGAALPPSATAAELRRAAAELERRERPFFRSCAPLARAEPREAAALLRKVAAQLETDGGLNWGRLLALVVFAGTLAAALAESACEEGPSRLAAALTAYLAEEQGEWMEEHGGWDGFCRFFGRHGSQPADQNSTLSNAIMAAAGFGIAGLAFLLVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SL15</accession>
    <name>A0A8C2SL15_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tetratricopeptide repeat protein 7B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">TTC7B</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis. In the complex, plays a central role in bridging PI4KA to EFR3B and HYCC1, via direct interactions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of a phosphatidylinositol 4-kinase (PI4K) complex, composed of PI4KA, EFR3 (EFR3A or EFR3B), TTC7 (TTC7A or TTC7B) and HYCC (HYCC1 or HYCC2). Interacts with PI4KA, interaction is direct. Interacts with EFR3 (EFR3A or EFR3B), interaction is direct. Interacts with HYCC (HYCC1 or HYCC2), interaction is direct. Association with the PI4K complex is strongly reduced by TMEM150A.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015720844.1">
        <property type="nucleotide sequence ID" value="XM_015865358.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SL15"/>
    <dbReference type="Ensembl" id="ENSCJPT00005000664.1">
        <property type="protein sequence ID" value="ENSCJPP00005000352.1"/>
        <property type="gene ID" value="ENSCJPG00005000437.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107315231"/>
    <dbReference type="CTD" id="145567"/>
    <dbReference type="GeneTree" id="ENSGT00940000158474"/>
    <dbReference type="OrthoDB" id="29013at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000030">
        <property type="entry name" value="Tetratricopeptide repeat domain 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000035">
        <property type="entry name" value="Tetratricopeptide repeat domain 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051722">
        <property type="entry name" value="Endocytosis_PI4K-reg_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045819">
        <property type="entry name" value="TTC7_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23083:SF365">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23083">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN, TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12895">
        <property type="entry name" value="ANAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19440">
        <property type="entry name" value="TTC7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 12" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Tetratricopeptide repeat protein 7 N-terminal" evidence="14">
        <location>
            <begin position="1"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="12">
        <location>
            <begin position="397"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="12">
        <location>
            <begin position="730"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="12">
        <location>
            <begin position="798"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00062872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00073839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF19440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005000352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="843" mass="94443" checksum="B52D48FB9320EB7D" modified="2022-01-19" version="1">MATKKAGSRLETEIERCRSECQWERIPELVKQLSAKLIANDDMAELLLGESKLEQFLKENALKQSSSPRGPRPKLTEVRKHLTAALDRGNLKPEFLQEANLLMAKLNYVEGDYKEALNTYARVGVDDLQLAAVPPYRLRMIAEAYSTKGLCLEKLPISSSASNLHVDREQEIVTCYEKAGDIALLYLQEIERVINTNIQNRSPKPGPTTHEQELGFFLETGLQRAHVLYFKNGNLTRGVGRFRELLRAVETRTTQNLRMTIARQLAEILLRGMCEQSYWNPLEDPPHQSPLDDPLRKGSNTKSYTLSRRPRVYTGENIFCPQENTEEALLLLLISESMANRDAVLSRIPEHKNDRIISLQSASVVYDLLTIALGRRGQYEMLSECLERAMKFAFEEFHLWYQFALSLMAAGKSARAVKVLKECIRLKPDDATIPLLAAKLCMGSLHWLEEAERFAKTVVDLGDKTSEFKAKGYLALGLTYSLQATDASLRGMQEVLQRKALLAFQRAHSLSPTDHLAAFYLALQLAISRQIPEALGYVRQALQLQGDDANSLHLLALLLSAQKHYHDALNIIDMALSEYPENFILLFTKVKLESLCRGPDEALLTCKHMLQIWKSCYNLTNPSDSGRGSSLLDRAIADRRQLNTITLPDFSDPETGSIHATSIAASRVEQALSEVASSLQSSAPKQGPLHPWMTLAQIWLHAAEVYIGIGKPAEATACTQEAANLFPMSHYVLYMRGQVAELRGNIDEAKRWYEEALSISPTHVKSMQRLALILHQLGRYSLAEKILRDAVQVNSTAHEVWNGLGEVLQAQGNDDAATECFLTALELEASSPVVPFTIIPRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SN36</accession>
    <name>A0A8C2SN36_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein transport protein Sec61 subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">SEC61G</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="11">The SEC61 channel-forming translocon complex consists of channel-forming core components SEC61A1, SEC61B and SEC61G and different auxiliary components such as SEC62 and SEC63. The SEC61 channel associates with the multi-pass translocon (MPT) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SecE/SEC61-gamma family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SN36"/>
    <dbReference type="SMR" id="A0A8C2SN36"/>
    <dbReference type="Ensembl" id="ENSCJPT00005000178.1">
        <property type="protein sequence ID" value="ENSCJPP00005000080.1"/>
        <property type="gene ID" value="ENSCJPG00005000142.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000001319"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005784">
        <property type="term" value="C:Sec61 translocon complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.820:FF:000001">
        <property type="entry name" value="Transport protein Sec61 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.820">
        <property type="entry name" value="Preprotein translocase SecE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00422">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023391">
        <property type="entry name" value="Prot_translocase_SecE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008158">
        <property type="entry name" value="Translocase_Sec61-g"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001901">
        <property type="entry name" value="Translocase_SecE/Sec61-g"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00327">
        <property type="entry name" value="secE_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12309">
        <property type="entry name" value="SEC61 GAMMA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00584">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103456">
        <property type="entry name" value="Preprotein translocase SecE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01067">
        <property type="entry name" value="SECE_SEC61G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005000080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="66" mass="7627" checksum="979A225485615CB6" modified="2022-01-19" version="1">MDQVMQFVEPSRQFVKDSIRLVKRCTKPDRKEFQKIAMATAIGFAIMGFIGFFVKLIHIPINNIIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SNF6</accession>
    <name>A0A8C2SNF6_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SNF6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005001558.1">
        <property type="protein sequence ID" value="ENSCJPP00005000878.1"/>
        <property type="gene ID" value="ENSCJPG00005000971.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01070000254325"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047126">
        <property type="entry name" value="RNF141-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12109">
        <property type="entry name" value="RING FINGER PROTEIN 141-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="41"/>
            <end position="80"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="94"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005000878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="143" mass="15518" checksum="71FE7DBA8FFBA41F" modified="2022-01-19" version="1">PAPQRPAAARVPTRRSSPARPAGPSEGSWRAGMATEEAWMCSICRDVRRDVASANPCKHTFCVGCIQRWAMLRDSCPLCRTCIVSPPAVPVPVGFGTATGPSGTAPSAPPSPGRQRKTGSRREWRRIVKEEMGKQILGLRRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SSE3</accession>
    <name>A0A8C2SSE3_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Electron transfer flavoprotein regulatory factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ETFRF1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I LYR family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_032302104.1">
        <property type="nucleotide sequence ID" value="XM_032446213.1"/>
    </dbReference>
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    <dbReference type="Ensembl" id="ENSCJPT00005005464.1">
        <property type="protein sequence ID" value="ENSCJPP00005003023.1"/>
        <property type="gene ID" value="ENSCJPG00005003264.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107317061"/>
    <dbReference type="KEGG" id="cjo:107317061"/>
    <dbReference type="CTD" id="144363"/>
    <dbReference type="GeneTree" id="ENSGT00390000001810"/>
    <dbReference type="OrthoDB" id="10258445at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004857">
        <property type="term" value="F:enzyme inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090324">
        <property type="term" value="P:negative regulation of oxidative phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20265">
        <property type="entry name" value="Complex1_LYR_ETFRF1_LYRM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045296">
        <property type="entry name" value="Complex1_LYR_ETFRF1_LYRM5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052000">
        <property type="entry name" value="ETFRF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21024:SF0">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN REGULATORY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21024">
        <property type="entry name" value="GROWTH HORMONE-INDUCIBLE SOLUBLE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="2">
        <location>
            <begin position="8"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005003023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="86" mass="10345" checksum="434DB36D57616A92" modified="2022-01-19" version="1">MARSLRGEVLNLYKNLLYLGKEYPKGADYFRSRLKAAFLKNKDVKDPEKIKELIARGEFVIKELEALYFLRKYRAMKKRYYSDDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SSZ8</accession>
    <name>A0A8C2SSZ8_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">KN motif and ankyrin repeat domains 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">KANK1</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015704369.1">
        <property type="nucleotide sequence ID" value="XM_015848883.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015704370.1">
        <property type="nucleotide sequence ID" value="XM_015848884.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005003609.1">
        <property type="protein sequence ID" value="ENSCJPP00005002012.1"/>
        <property type="gene ID" value="ENSCJPG00005002171.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005003613.1">
        <property type="protein sequence ID" value="ENSCJPP00005002013.1"/>
        <property type="gene ID" value="ENSCJPG00005002171.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005003625.1">
        <property type="protein sequence ID" value="ENSCJPP00005002020.1"/>
        <property type="gene ID" value="ENSCJPG00005002171.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107306077"/>
    <dbReference type="KEGG" id="cjo:107306077"/>
    <dbReference type="CTD" id="23189"/>
    <dbReference type="GeneTree" id="ENSGT00940000154886"/>
    <dbReference type="OrthoDB" id="5406014at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome Z"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032587">
        <property type="term" value="C:ruffle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008283">
        <property type="term" value="P:cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043622">
        <property type="term" value="P:cortical microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030837">
        <property type="term" value="P:negative regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030336">
        <property type="term" value="P:negative regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046627">
        <property type="term" value="P:negative regulation of insulin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000393">
        <property type="term" value="P:negative regulation of lamellipodium morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010977">
        <property type="term" value="P:negative regulation of neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035024">
        <property type="term" value="P:negative regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900028">
        <property type="term" value="P:negative regulation of ruffle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900025">
        <property type="term" value="P:negative regulation of substrate adhesion-dependent cell spreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090521">
        <property type="term" value="P:podocyte cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090263">
        <property type="term" value="P:positive regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090303">
        <property type="term" value="P:positive regulation of wound healing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000114">
        <property type="term" value="P:regulation of establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000017">
        <property type="entry name" value="KN motif and ankyrin repeat domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047184">
        <property type="entry name" value="KANK1-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021939">
        <property type="entry name" value="KN_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24168">
        <property type="entry name" value="KN MOTIF AND ANKYRIN REPEAT DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24168:SF19">
        <property type="entry name" value="KN MOTIF AND ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12075">
        <property type="entry name" value="KN_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="1153"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="1225"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="1258"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="65"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1000"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1321"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="440"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1010"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1028"/>
            <end position="1042"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005002013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1344" mass="146990" checksum="90AB677C26983A4B" modified="2022-01-19" version="1">MAYPANTNGSAAEKEEVIINGKDENERKYPYFVETPYGYQLDLDFLKYVDDIQKGNTIKKLNIQKKRKAVPASRSTKSSGGHCGDWTSTESLSSSNSDENKQSFLLTRSQVTSSVAVRPLASLEASPSYLTVPESKQLPPPSPQLPRHNLHVTKTLMETRRRLEQERMMQVMPGDVRRPRLSSFGGMGSTSSLPSFVGSSGYGHLPQQLHNGYQGNGDFGACFGSSLGSSIRHSPMSSGISTPVTNVSPVHLQQIREQMAIALKRLKELEEQVKTIPVLQVKISVLQEEKRHMMAELKSQRKSSQNDMYGFRKRSYSAGNAEQWEHLSQVRRGGELYIDCEDEMESAEQSSRRVEEFRQLTAEMQALEKKIQDSNYEVPSNLRESLTKESRSVAVGSDENMSDVVIYNRSSRQHREVAVGTEKEVRESGVGVTEAMLGLSTEVEKEIELQQQTIEALKEKIYRLEVQLKETTHDREMTKLKQELQAAGSRKKVDKAVMAQPLVISRMVEAVVQMRDQMVGDHVHVADSSVGSHLQMSSVGTSCRPAVRSTAAGPELLMSRWLVRERAEMRDQCTGRCVELLDKKVGVETSVCETGVNTEESVGDLSLCRTVREVRETRSIGCGDCSVDVVVCAPKECVSRQTATETVCRAEATVMAVPSTATQQTSTAMEMVSRCTSTEAPVAVDCGTNTVPSSRDQQTSTVSVEMRTVAVGDGRVKDIHASAKTRSVGVGTLLSTPAGFEKLSVIKTKDCGVGQININENYLVGLKMRSIACGPPPLVVVPTSTRSIGVGGEPVCESVSNLLESPLPPPELRTGLDHYIERVQKLLQEQQMLLAENYSELAEAFGEPHSQIGSLNSQLISTLTSINSVMKYASTEELRSLDLQKQCMEKSTASGATLEYIPHGQLANTHLTSDLRALKLEQDVVPAQEEKKTPLLEAARGRKSFSSQDKTLAAINLTDDQLASRLYVCSNSENTLKSIMKKRDGKKDLSNTKKNLQFVGINGGYETTSSDDSSSEESSSSDSEEECEGHVYPHGRGTDGEHPVLGPPETSAAGTAKDGPPLECEAEEVEIRERYELSEKMLSACHLLKNNIDDPKALTNKDVRFCLNTIQHEWFRVSSQKSAVPEMVGDYINAFEEISPAVLRHIINVADGNGNTALHYSVSHSNFEIVKLLLDANVCNVNHQNKAGYTPIMLAALAAVEAEKDMRIVEELFSCGDVNAKASQAGQTALMLAVSHGRIDMVKALLACGADVNIQDDEGSTALMCASEHGHVEIVKLLLAQPGCNGTLEDNDGSTALSIALEAGHKDIAVLLYAHVNFSKTQSPGTPRLSRKTSPGPTHRAAFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2STL2</accession>
    <name>A0A8C2STL2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2STL2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005006336.1">
        <property type="protein sequence ID" value="ENSCJPP00005003610.1"/>
        <property type="gene ID" value="ENSCJPG00005003752.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157147"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042392">
        <property type="term" value="F:sphingosine-1-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969:SF17">
        <property type="entry name" value="INACTIVE PHOSPHOLIPID PHOSPHATASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005003610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="115" mass="13001" checksum="91122529A45CF8B5" modified="2022-01-19" version="1">MIVAGLQKLAKRKGPYDISPGLLDYLTMDTYAFPAGHASRAAMLSKFLLNHLVLAIPLRILLVIWAFCVGFSRVMIGRHHITDVLSGFVFGYLQFRLVELIWMSSNTCQMLISIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2STZ2</accession>
    <name>A0A8C2STZ2_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2STZ2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005003592.1">
        <property type="protein sequence ID" value="ENSCJPP00005002008.1"/>
        <property type="gene ID" value="ENSCJPG00005002163.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000168812"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005002008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="89" mass="8978" checksum="AB65273C554D5D70" modified="2022-01-19" version="1">MEGGGNTGTKGSGLGGLFGTGGAGYSHADLAGVPLTGMSPLSPYLNLDPKYLVQVRSALGSSCWGCCGRVGRALNAHRATRSLQPTRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SV61</accession>
    <name>A0A8C2SV61_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Coiled-coil domain containing 90B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">CCDC90B</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CCDC90 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SV61"/>
    <dbReference type="Ensembl" id="ENSCJPT00005007227.1">
        <property type="protein sequence ID" value="ENSCJPP00005004292.1"/>
        <property type="gene ID" value="ENSCJPG00005004187.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155453"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000015">
        <property type="entry name" value="Mitochondrial calcium uniporter regulator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024461">
        <property type="entry name" value="CCDC90-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14360:SF14">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 90B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14360">
        <property type="entry name" value="PROTEIN FMP32, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07798">
        <property type="entry name" value="CCDC90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005004292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="270" mass="30353" checksum="70FC5D23BD45651E" modified="2022-01-19" version="1">MLGESSSLGEWLGPGTGCPGSFGVMKEVKAAISCDKPSRLSLKHVLSLPGLAATLPRYSYDVRRVEITPPEQRKVTFDTHALVRDLEAHGFAKEQAETIVSALITLSNVSLETVYKDMVTQAQQEITLQQIMAHLDSIRKDMVILEKSEFANLRAENEKMKIELDQVKQQLMNETGKIQADSKLDINLERSRVTDMFTDQERKLMEATTEFHKKDSSTNSIISEISNKIDTEIASLKTLMESNKLDTIRYLAASVFTCLAIALGFYRFWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SYB1</accession>
    <name>A0A8C2SYB1_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CDV3 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CDV3</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDV3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SYB1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005007285.1">
        <property type="protein sequence ID" value="ENSCJPP00005004347.1"/>
        <property type="gene ID" value="ENSCJPG00005004313.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000000805"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026806">
        <property type="entry name" value="CDV3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16284">
        <property type="entry name" value="PROTEIN CDV3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16284:SF13">
        <property type="entry name" value="PROTEIN CDV3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15359">
        <property type="entry name" value="CDV3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="133"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="161"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="185"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="231"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005004347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="401" mass="41954" checksum="EB12A8217D2715FB" modified="2022-01-19" version="1">MVSTEPAPDLTADISLGAGSCGTTQCHSLCDPALASSRPISSRAASSPHATHSRVATSASLPGGFGLAGGRFLLGRSLAEGLRRTRGSALPSPGSPAPCAWSRPWRSVPCQAAAAACGAVQCGAVRFHGRARPAAERSGPHLLARPPPLGAAPDPAAMAETEERSLDDFFAKRDKKKRKEKSGRSATAASTASSASSAASNATGAASAAGGPRPTDGGASGAAGSVSGSAKSKEEDDWKEFEQKEEIDYSGLRVQSMQISEKEDDESEKREEPSDNWEETSGAVDRSSGPWNKSAPAPAPVVETIVTEPPEPVQTGGVYRPPGAREGGRPRRAQQGPPEIYSDTQFPSLQSTAKLVDSRKDKEMEKSFEVVKHKTRGRDEVSKNQALKLQLDNQYAVLGDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SYR1</accession>
    <name>A0A8C2SYR1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Collagen alpha-1(XIV) chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">COL14A1</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the fibril-associated collagens with interrupted helices (FACIT) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015711672.1">
        <property type="nucleotide sequence ID" value="XM_015856186.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005009325.1">
        <property type="protein sequence ID" value="ENSCJPP00005005822.1"/>
        <property type="gene ID" value="ENSCJPG00005005501.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107310493"/>
    <dbReference type="CTD" id="7373"/>
    <dbReference type="GeneTree" id="ENSGT00940000153769"/>
    <dbReference type="OrthoDB" id="18894at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005614">
        <property type="term" value="C:interstitial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030199">
        <property type="term" value="P:collagen fibril organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048873">
        <property type="term" value="P:homeostasis of number of cells within a tissue"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061050">
        <property type="term" value="P:regulation of cell growth involved in cardiac muscle cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003229">
        <property type="term" value="P:ventricular cardiac muscle tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="CDD" id="cd01482">
        <property type="entry name" value="vWA_collagen_alphaI-XII-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000403">
        <property type="entry name" value="collagen alpha-1(XIV) chain isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000444">
        <property type="entry name" value="Collagen alpha-1(XIV) chain isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000514">
        <property type="entry name" value="Collagen alpha-1(XIV) chain isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000546">
        <property type="entry name" value="Collagen alpha-1(XIV) chain isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000615">
        <property type="entry name" value="collagen alpha-1(XIV) chain isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000656">
        <property type="entry name" value="collagen alpha-1(XIV) chain isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000008">
        <property type="entry name" value="Collagen type XII alpha 1 chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000234">
        <property type="entry name" value="Collagen, type XII, alpha 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000001">
        <property type="entry name" value="Collagen, type XII, alpha 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050525">
        <property type="entry name" value="ECM_Assembly_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048287">
        <property type="entry name" value="TSPN-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020:SF15">
        <property type="entry name" value="COLLAGEN ALPHA-1(XIV) CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00453">
        <property type="entry name" value="VWFADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00210">
        <property type="entry name" value="TSPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="8" id="KW-0176">Collagen</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0379">Hydroxylation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034990301" description="Collagen alpha-1(XIV) chain" evidence="15">
        <location>
            <begin position="29"/>
            <end position="1860"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="32"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="16">
        <location>
            <begin position="158"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="355"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="445"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="537"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="628"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="744"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="838"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="16">
        <location>
            <begin position="1045"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="110"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1475"/>
            <end position="1623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1657"/>
            <end position="1770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1776"/>
            <end position="1795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1586"/>
            <end position="1596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="1669"/>
            <end position="1678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1680"/>
            <end position="1695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1702"/>
            <end position="1714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="1742"/>
            <end position="1751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00067377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005005822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1860" mass="199838" checksum="B361BD212D169BBF" modified="2022-01-19" version="1">MLCWNEVQSCFLLAFLAVAAYSVSDAQGQVSPPTRLRYNVVNPDSVQISWKAPKGQFSGYKLLVTPSSGGKTNQLILQNTATKAIIQGLIPDQNYALQIIAFSDDKESKPAQGQFRIKDIERRKETSKSKVKDPEKTNASKPAPEGNLFTCKTPAIADIVILVDGSWSIGRFNFRLVRLFLENLVSAFNVGSEKTRVGLAQYSGDPRIEWHLNAYGTKDAVLDAVRNLPYKGGNTLTGLALTYILENSFKPEAGARPGVSKIGILITDGKSQDDVIPPAKNLRDAGIELFAIGVKNADINELKEIASEPDSTHVYNVADFNFMNTIVEGLTRTVCSRVEEQEKEIKGTIAASLGAPTELVTSDITARGFRVSWTHAPGKVEKYRVVYYPTRGGQPEEVVVDGSSSTAVLKNLMSLTEYQIAVFAIYSNAASEGLRGTETTLALPMASDLKLYDVSHSSMRAKWNGVAGATGYMILYAPLTEGLAADEKEIKIGEASTELELDGLLPNTEYTVTVYAMFGEEASDPLTGQEMTLPLSPPSNLKFSDVGHNSAKLTWDPASKNVKGYRIMYVKTDGTETNEVEVGPVSTHTLKSLTALTEYTVAIFSLYDEGQSEPLTGSFTTRKVPPPQHLEVDEASTDSFRVSWKPTSSDIAFYRLAWIPLDGGESEEVVLNGDADSYVIEGLLPNTEYEVSLLAVFDDETESEVVAVLGATFAGTTAIPTTVTTTTTTTTTTPKPTIAVFRTGVRNLVIDDETTSSLRVVWDISDYSVQQFRVTYLTATGDRAEEAVRTIMVPGRQNTLLLQPLLPDTEYKVTITPIYADGEGVSVSAPGKTLPLSAPRNLRVSDEWYNRLRISWDAPPSPTMGYRIVYKSMNIPGPALETFVGDDINTILILNLFSGTEYSVKVFASYSTGFSDALTGVAKTLYLGVTNLDTYQVRMTSLCTQWQLHRHATAYRVVIESLVDGKKQEVNLGGGTPRHCFFELMPGTEYKISVHAQLQEIEGPAVSIMETTLQLPTQPPTFPSTPPPPPTIPPAKEVCKAAKADLVFLVDGSWSIGDDNFNKIISFLYSTVGALDKIGPDGTQVAIIQFSDDPRTEFKLNAYKTKETLLEAIQQIAYKGGNTKTGKAIKHAREVLFTGEAGMRKGIPKVLVVITDGRSQDDVNKVSREMQLDGFSFFAIGVADADYSELVNIGSKPSERHVFFVDDFDAFTKIEDELITFVCETASATCPLVFKDGDNFAGFKMMEMFGLVEKEFSAIDGVSMEPGTFNVYPCYRLHKDALVSQPTKYLHPEGLPSDYTITFLFRILPDTPQEPFALWEILNEQYEPLVGVILDNGGKTLTFFNYDYKGDFQTVTFEGPEIRKIFYGSFHKLHVVISKTTAKIIIDCKEAGEKTINAAGNISSDGIEVLGRMVRSRGPRDNSAPLQLQMFDIVCATSWANRDKCCELPGLRDEENCPALPHACSCSEANKGPLGPPGPPGGPGVRGAKGHRGDPGPKGPDGPRGEIGVPGPQGPPGPQGPSGLSIQGLPGPPGEKGEKGDLGFPGLQGVPGASGSPGRDGAQGQRGLPGKDGPTGPQGPPGPVGIPGAPGVPGITGSQGPQGDVGAPGAPGPKGERGERGDLQSQAMVRAVARQVCEQLIQGHMARYNSILNQIPSQSVSTRTIAGPPGEPGRPGAPGPQGEQGSPGMQGFPGNPGQPGRPGERGLPGEKGDRGNPGVGTQGPRGPPGSTGPPGESRTGSPGPPGSPGPRGPAGHTGPPGSQGPAGPPGYCDPSSCAGYGMGGGYGEPTDQDIPVVQLPHNSYQIYDPEDLYDEFTPVREEMEAVELRSPGISRFRRKIAKRSIKNLEHKRENGKEPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SZU9</accession>
    <name>A0A8C2SZU9_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Fibroblast growth factor receptor-like 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">FGFRL1</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Has a negative effect on cell proliferation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015718149.1">
        <property type="nucleotide sequence ID" value="XM_015862663.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SZU9"/>
    <dbReference type="SMR" id="A0A8C2SZU9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005008183.1">
        <property type="protein sequence ID" value="ENSCJPP00005004971.1"/>
        <property type="gene ID" value="ENSCJPG00005004823.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107313938"/>
    <dbReference type="KEGG" id="cjo:107313938"/>
    <dbReference type="CTD" id="53834"/>
    <dbReference type="GeneTree" id="ENSGT00940000156736"/>
    <dbReference type="OrthoDB" id="6244905at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044291">
        <property type="term" value="C:cell-cell contact zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030133">
        <property type="term" value="C:transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017134">
        <property type="term" value="F:fibroblast growth factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005007">
        <property type="term" value="F:fibroblast growth factor receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098742">
        <property type="term" value="P:cell-cell adhesion via plasma-membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003179">
        <property type="term" value="P:heart valve morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001501">
        <property type="term" value="P:skeletal system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060412">
        <property type="term" value="P:ventricular septum morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd05856">
        <property type="entry name" value="IgI_2_FGFRL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000016">
        <property type="entry name" value="Fibroblast growth factor receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000246">
        <property type="entry name" value="Fibroblast growth factor receptor like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000593">
        <property type="entry name" value="Fibroblast growth factor receptor-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052615">
        <property type="entry name" value="FGFRL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19890">
        <property type="entry name" value="FIBROBLAST GROWTH FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19890:SF10">
        <property type="entry name" value="FIBROBLAST GROWTH FACTOR RECEPTOR-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 15" id="KW-0732">Signal</keyword>
    <keyword evidence="2 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034085161" description="Fibroblast growth factor receptor-like 1" evidence="15">
        <location>
            <begin position="19"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="368"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="23"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="141"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="240"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="115"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00053149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00074412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005004971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="487" mass="54099" checksum="FFD0132AD917FF94" modified="2022-01-19" version="1">MGLQLALLLAGIVALSDSARGPPRIADKVIHRQSVRLGRTIKLLCPVEGDPPPLTMWMKDGRTIHSGWTRFRILQQGLKIKEVESEDAGTYICKATNGFGSTNVNYTLIVIDDTSSGKNSQTPEGSNGEYEDHSGKQWAQPRFTQPAKMRRRVIARPVGSSIRLKCVASGNPRPDITWLKDNKPLMPHEIGENKKKKWTLNLKNLKPEDSGKYTCRVFNKVGEINATYKVEVIQRTRSKPILTGTHPVNTTVDYGGTTSFQCKVRSDVKPVIQWLKRVEYGTESKYNSTIDVGGQKFVVLPTGEVWSRPDGSYLNKLMITRAKEEDAGMYICLGANTMGYSFRSAFLTVLPDPKPPSAPVPPSSVSSLPWPVIIGIPAGAVFIFGTILLWLCQTKKKPCSPPAAAPVHRPQPRDRICVSQVPDKDCISSINYEEYVAQQQHLLSQGPALAPAMASKMYPKIYTDIHTHTHSHVEGKVHQHQHIQYQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T087</accession>
    <name>A0A8C2T087_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc-binding protein A33-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC107320151</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
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            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <property type="nucleotide sequence ID" value="XM_015875741.2"/>
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        <property type="entry name" value="Butyrophilin subfamily 1 member A1"/>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
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        <property type="entry name" value="TRIM8/14/16/25/29/45/65_CC"/>
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        <property type="entry name" value="Znf_RING"/>
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        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
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        <property type="entry name" value="Znf_RING_CS"/>
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        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM"/>
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        <property type="entry name" value="zf-C3HC4_4"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="BUTYPHLNCDUF"/>
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        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
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        <property type="entry name" value="RING/U-box"/>
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    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="16"/>
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        <source>
            <dbReference type="SAM" id="Coils"/>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
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        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005005988.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
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    <sequence length="427" mass="49565" checksum="2E415896015A5CE3" modified="2022-01-19" version="1">MAAVGREHSLREELTCAICHELFEQPVMLDCMHHYCRACIQRYWHSTPRVASCPQCRREFPRPTFRTHHLLAGLVDKVRLCGSREHRHHVQKRLEEALQAHQKEMEKFLQQKRAVQGDICSLTKASGELNFKIRAQFTRLHQILEEEERAVLAQLGKEEEQALARLHGDVHQLEEGMAMLRRDMERLEQTLSNMDEVSLLEVESLDIRPSVSVKPLPAFDLQHYRDSHGGPLQYIFWRQMLQSICPVPASLTFDPESAHPNLVFSRDLTAVTERERAQPVPRSPRRFQQCVNVMASRTFDCGQHYWEVWVGSKTKWDLGVAAEAVNRAAKVKLCPENGYWTLRLRNKTEYWATATPWVRLFPKQPPRKVGVFLDCQEGTVAFFDAQDMSHLFTFHEVSAERYCPFFSTCFSDGRDNVEPMRICHLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T129</accession>
    <name>A0A8C2T129_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Dynein axonemal intermediate chain 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Axonemal dynein intermediate chain 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">DNAI1</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Part of the dynein complex of respiratory cilia.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Consists of at least two heavy chains and a number of intermediate and light chains. Interacts with BICD2. Interacts with CFAP45 and CFAP52. Interacts with CFAP53.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein intermediate chain family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T129"/>
    <dbReference type="Ensembl" id="ENSCJPT00005009579.1">
        <property type="protein sequence ID" value="ENSCJPP00005006028.1"/>
        <property type="gene ID" value="ENSCJPG00005005679.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156436"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome Z"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097729">
        <property type="term" value="C:9+2 motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
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        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097386">
        <property type="term" value="C:glial cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036157">
        <property type="term" value="C:outer dynein arm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045503">
        <property type="term" value="F:dynein light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007368">
        <property type="term" value="P:determination of left/right symmetry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003351">
        <property type="term" value="P:epithelial cilium movement involved in extracellular fluid movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030317">
        <property type="term" value="P:flagellated sperm motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007507">
        <property type="term" value="P:heart development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008286">
        <property type="term" value="P:insulin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036158">
        <property type="term" value="P:outer dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000251">
        <property type="entry name" value="Dynein axonemal intermediate chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Dynein axonemal intermediate chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050687">
        <property type="entry name" value="Dynein_IC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442:SF11">
        <property type="entry name" value="DYNEIN AXONEMAL INTERMEDIATE CHAIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442">
        <property type="entry name" value="DYNEIN INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0243">Dynein</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 15" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="15">
        <location>
            <begin position="508"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="109"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="113"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00053763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00061734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00072661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00080372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="702" mass="79411" checksum="DEECF75594421278" modified="2022-01-19" version="1">MPAKAADKQRQSQSGPQGGKAGQPRLSLKKRDEDTATEGGEGVDESTAVRPLGQLELTEAELKKEITRVLTANNPHAPKNIVRYNFKERAYKPISNIDQTAIHFSLKGNLIPKDSDEGRRQSLRSEKAPETSAEVSQEAEIKDEKSTEDTQAAEEAKAEGAGEAEAAEEPPPPQKKEKKLANQFNFIERSSRTRDNPLRWKIYDAYVVEVEKMEKLKEKEKPKTQTAKKEEKKKEKKLTSMELQGDAITKISSAAKIMERMVNQNIFDDIAQDFKYFEDASDEYRDHKGTLLPLWKFQYDKTKRLAVTAISWNPKYKDLFAVGYGSYDFMKQSRGMLVLYTMKNPSFPEYVFSSESGIMCLDIHNDHPHFMAVGFYDGNVAIYNLKKATSQPSYMSRAKSGKHSDPVWQVKWQKDDMDNNLNFFSVSSDGRIVSWTLVKNELVHTDVIKLSAERTTTQGPEGLQLQTIGCGTSFDFHKTIDYLFLVGTEEGKIYKCSKCYSNQFLDVFEAHHMAVDSISWNPYHLKIFISCSSDWTVKIWDHTIKTPMFVYDLNAAVGDVAWSPYSSTVFAAVTTDCKAHVFDMNVNKYEALCSQVVVAKKKNKTTHIQFNPVYPVVIVGDERGQVTCLKLSPNLRKMPKVSSAEGPNHSRSLHAFTVLSTLCSELGKVALSCRVLKVTRSLLSRMSRMSDPFFCFCWSKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T1G3</accession>
    <name>A0A8C2T1G3_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Meiotic double-stranded break formation protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">MEI4</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the MEI4L family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015714545.1">
        <property type="nucleotide sequence ID" value="XM_015859059.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T1G3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005008882.1">
        <property type="protein sequence ID" value="ENSCJPP00005005476.1"/>
        <property type="gene ID" value="ENSCJPG00005005239.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107312037"/>
    <dbReference type="KEGG" id="cjo:107312037"/>
    <dbReference type="CTD" id="101928601"/>
    <dbReference type="GeneTree" id="ENSGT00390000013856"/>
    <dbReference type="OrthoDB" id="6351423at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000800">
        <property type="term" value="C:lateral element"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007129">
        <property type="term" value="P:homologous chromosome pairing at meiosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042138">
        <property type="term" value="P:meiotic DNA double-strand break formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048477">
        <property type="term" value="P:oogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025888">
        <property type="entry name" value="MEI4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28575">
        <property type="entry name" value="MEIOSIS-SPECIFIC PROTEIN MEI4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28575:SF1">
        <property type="entry name" value="MEIOSIS-SPECIFIC PROTEIN MEI4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13971">
        <property type="entry name" value="Mei4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0469">Meiosis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00093453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005005476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="411" mass="46970" checksum="0CA9770EB3F98C7B" modified="2022-01-19" version="1">MEPRSVPQGGELAAEVKGRRENQIWYLKISKLALAFAIIRSKPPGKSCKEYTEHLAKIVSEQDFDYKSKVTALEAEVFRLRQELLLNKICQRVCLENGKPGASAETLLDEERLNPMSYSSQLQDSGCDVSDDYAFESLGIASDIQELEHSVNTSKRWLEIVPPLNLCCASKEESLTVPVQFFQHLLEIRKLSEGGMLQADFTELENDSFTICNSVSQLLDGLTVFYNSPELPVSSFLTEAVCVLIRLVTDAKLSNHVLKKCFRKLEEFMKNLIQIILRNSNVNRFQALDAVSHTLVLLGRNNVLRNSLVSFLLSELQQFAEQMWQAYQVQEMYDVTQYENIFSLFMILEQLLHNDTEESKASDSGYGEEEKIKFLKNLDEIILHLSDEFPLFSLYLWRLSVLLNSAQIRID</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T1T8</accession>
    <name>A0A8C2T1T8_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T1T8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005011009.1">
        <property type="protein sequence ID" value="ENSCJPP00005007087.1"/>
        <property type="gene ID" value="ENSCJPG00005006542.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160859"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18229">
        <property type="entry name" value="BTB_POZ_ZBTB45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050457">
        <property type="entry name" value="ZnFinger_BTB_dom_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46105">
        <property type="entry name" value="AGAP004733-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46105:SF22">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN CONTAINING 45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="100"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005007087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="333" mass="36051" checksum="4E6265BB3F46B3E4" modified="2022-01-19" version="1">MGSIGQPDPLQLPLVSMVRGGWRTAALYDPRSLPPIFLTGSDVLTGNRKRRLCGAVAGGAGKRSPHHLPMAEPVHSIHLHNFSRSLLETLNVQRLGGHFCDVTVRIRDSTFRAHRCVLAAGSPFFHDKLLLGHSAIEVPPVVPSGAVRRLLEFLYSGCLAVARSEALQMLTAASVLQIKTVIDECTQIICQGHKGLPPNRPPAGCIALGWYHSEPPGLLDGGGTTRTILGYWMGVVPLGTILGYWMGVVPLGTILGYGWVGTTRNHPGYWVGVVPLGTTSWLLDGGGTSPEPSWVIGWGRYHPEPSWCIGWGSVPTRKPSWVIGWGWYTQTPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T2E3</accession>
    <name>A0A8C2T2E3_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Myosin VIIA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">MYO7A</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSCJPT00005008856.1">
        <property type="protein sequence ID" value="ENSCJPP00005005459.1"/>
        <property type="gene ID" value="ENSCJPG00005004544.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155350"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042470">
        <property type="term" value="C:melanosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005902">
        <property type="term" value="C:microvillus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032391">
        <property type="term" value="C:photoreceptor connecting cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001917">
        <property type="term" value="C:photoreceptor inner segment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001750">
        <property type="term" value="C:photoreceptor outer segment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120044">
        <property type="term" value="C:stereocilium base"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030507">
        <property type="term" value="F:spectrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030048">
        <property type="term" value="P:actin filament-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060088">
        <property type="term" value="P:auditory receptor cell stereocilium organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090102">
        <property type="term" value="P:cochlea development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050957">
        <property type="term" value="P:equilibrioception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001845">
        <property type="term" value="P:phagolysosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051904">
        <property type="term" value="P:pigment granule transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007605">
        <property type="term" value="P:sensory perception of sound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd17092">
        <property type="entry name" value="FERM1_F1_Myosin-VII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17093">
        <property type="entry name" value="FERM2_F1_Myosin-VII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd13198">
        <property type="entry name" value="FERM_C1_MyoVII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13199">
        <property type="entry name" value="FERM_C2_MyoVII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01381">
        <property type="entry name" value="MYSc_Myo7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000012">
        <property type="entry name" value="Myosin VIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.530:FF:000004">
        <property type="entry name" value="Myosin VIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000007">
        <property type="entry name" value="Myosin VIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000013">
        <property type="entry name" value="Unconventional myosin-VIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000075">
        <property type="entry name" value="unconventional myosin-VIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000079">
        <property type="entry name" value="unconventional myosin-VIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000113">
        <property type="entry name" value="unconventional myosin-VIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000036">
        <property type="entry name" value="Unconventional myosin-VIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000051">
        <property type="entry name" value="Unconventional myosin-VIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.530">
        <property type="entry name" value="MyTH4 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002404">
        <property type="entry name" value="IRS_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057130">
        <property type="entry name" value="Myosin_VII_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041793">
        <property type="entry name" value="MyoVII_FERM_C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041794">
        <property type="entry name" value="MyoVII_FERM_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036106">
        <property type="entry name" value="MYSc_Myo7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000857">
        <property type="entry name" value="MyTH4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038185">
        <property type="entry name" value="MyTH4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051567">
        <property type="entry name" value="Unconventional_Myosin_ATPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22692">
        <property type="entry name" value="MYOSIN VII, XV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22692:SF34">
        <property type="entry name" value="MYOSIN VIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21998">
        <property type="entry name" value="FERM_C1_MyoVII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02174">
        <property type="entry name" value="IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24123">
        <property type="entry name" value="Myosin_VII_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00784">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21989">
        <property type="entry name" value="RA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00139">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51016">
        <property type="entry name" value="MYTH4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 12" id="KW-0505">Motor protein</keyword>
    <keyword evidence="8 12" id="KW-0518">Myosin</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 11" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="Myosin motor" evidence="18">
        <location>
            <begin position="64"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="domain" description="MyTH4" evidence="17">
        <location>
            <begin position="1016"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="domain" description="FERM" evidence="16">
        <location>
            <begin position="1259"/>
            <end position="1568"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="15">
        <location>
            <begin position="1566"/>
            <end position="1635"/>
        </location>
    </feature>
    <feature type="domain" description="MyTH4" evidence="17">
        <location>
            <begin position="1710"/>
            <end position="1862"/>
        </location>
    </feature>
    <feature type="domain" description="FERM" evidence="16">
        <location>
            <begin position="1868"/>
            <end position="2171"/>
        </location>
    </feature>
    <feature type="domain" description="PID" evidence="14">
        <location>
            <begin position="2097"/>
            <end position="2124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="12">
        <location>
            <begin position="617"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="866"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="157"/>
            <end position="164"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005005459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="2181" mass="251259" checksum="B7210D9E9CBEC8EB" modified="2022-01-19" version="1">MGLGLGDYVWMDLKTGREFDVPIGAVVKLCDSGQIQVVDDEGNEHWISPQNATHIKPMHPTSIHGVEDMIRLGDLNEAGILRNLLIRYREHLIYTYTGSILVAVNPYQLLPIYSPEQIRLYTNKKIGEMPPHIFAIADNCYFNMQRNNKDQCCIISGESGAGKTESTKLILQFLAAISGQHSWIEQQVLEANPILEAFGNAKTIRNDNSSRFGKYIDIHFNKRGAIEGAKIEQYLLEKSRVCRQAQDERNYHVFYCMLRGMTMEQKKKLGLGKATDYNYLAMGNCTTCDGRDDSKEYANIRSAMKVLMFTDTENWEISKLLAAILHMGNLKYEARTYDNLDACEVVQSASLITAASLLEVSPQDVMNCLTSRTIITRGETVSTPLSMEQALDVRDAFVKGIYGRLFVWIVEKINAAIYRPPSQELKSVRRSIGLLDIFGFENFTVNSFEQLCINFANENLQQFFVRHVFKLEQEEYNLENINWQHIEFTDNQDALDMIAIKPMNIISLIDEESKFPKGTDATMLHKLNSQHKLNTNYIPPKNNYETQFGINHFAGIVYYETKGFLEKNRDTLHGDIIQLVHSSKNKFIKQIFQADVAMGAETRKRSPTLSSQFKRSLELLMRTLSVCQPFFVRCIKPNEYKKPMLFDRELCVRQLRYSGMMETIRIRRAGYPIRYTFVEFVDRYRVLMPGVKPAYKQGDLRGTCQRIAEAVLGKDDDWQIGKTKIFLKDHHDMLLEIERDKAITDKVILIQKVVRGFKDRSNFLKVRNSVLMIQRYWRGHNCRKNYGAMRIGFLRLQALYRSRKLHKQYHMARRRIIEFQARCRGYLVRRAFRHRLWAVLTVQAYARGMIARRLYKRLRGEYHRRLEAEKLRLAEEERLRKEMSAKKAKEEAEKKHQVRLAQLAREDAEREVKEKEEARRKKELLEKMERARNEPVNDSEMVDKMFGFLGTTSSLPGQEGQAPNGFEDLERAQKELEEEDLDAALPLPEEEEEDLSEYKFAKFAATYFQGTTTHTYIRRPLKQPLLYHEDEGDQLAALAVWITILRFMGDLPEPKYHTAMSDGGEKIPVMTKIYETLGKKTYKKELQALQGEGEVISTHIDGHKKNSVRHKLVSLTLKKKSKLTEEVTKRLHDGESTLQGNSMLEDRPTSNLEKLHFIIGNGILRPALRDEIYCQICKQLTQNPSKSSHARGWILMSLCVGCFAPSEKFVKYLRNFINGGPPGYAPYCEERLRRTFANGTRTQPPSWLELQATKSKKPIMLPVTFMDGTTKTLLTDSATTAKELCNSLADKISLKDRFGFSLYIALFDKVSSLGSGNDHVMDAVSQCEQYAKEQGAQERNAPWRLFFRKEIFTPWHNPSEDNVATNLIYQQIVRGVKFGEYRCDKEEDLAELASQQYYVDYGSEMVLERLLNLIPSYIPDREITASKTVEKWAQLIIAAHKKGIYTQKRTDPKKVKEEVVDFARFKWPLLFSRFYEAFKFSGPSLPKNDVIVAVNWTGVYFVDEQEQVLLELSFPEITAVSSSRGGKLQGQSFTLATIKADEYTFTSNNAEDIRDLVVTFLEGLRKRSKYVVSLQDNPNPVGEESGFLSFLKGDLIVLDQDTGEHVMNSGWANGFNERTKQKGDFPTDSVYVLPTVTMPPLEIVALVTMTPDQRQDVIRASQMAISDSEERVKPYTLEEFSYDYFRPPPKHTLSRVMITKSRGKDKLWCYTREPIKQPLLKKILGSEELSQEACMAFIDILLLPGYMGDYPSKRTRSVNELTDQIFEGALKAEPLKDEIYCQTLKQLTDNHIKYSEEKGWELLWLCTGLFPPSNILLPHVQRFLQSRKHHPLAADCIQRLQKALRNGSRKYPPHLVEVEAIQHKTTQIFHKVYFPDDTDEAFEVESSTKAKDFCQNISNRLLLKSSEGFSLFVKISDKVISVPEGDFFFDFVRHLTDWIKKARPAKDGIVPSLTYQVFFMKKLWTNTTPGKDSMADSIFHYYQELPKYLRGYHKCTREEVLQLAALIYRVKFEDDKSYFPSIPKLLKELVPQDLVRQLSPDDWKRSIVAYYNKHAGKTREEAKLAFLKIIFKWPTFGSAFFEVKQTTEPNYPEILLIAINKHGVSLIDPKTKDILITHPFTKISNWSSGNTYFHITIGNLVRGSKLLCETSLGYKMDDLLTSYISQMLTAMSKQRSAKGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T2T7</accession>
    <name>A0A8C2T2T7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Hyaluronidase</fullName>
            <ecNumber evidence="13">3.2.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">HYAL1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random hydrolysis of (1-&gt;4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.</text>
            <dbReference type="EC" id="3.2.1.35"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the glycosyl hydrolase 56 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.35" evidence="13"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2T2T7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005009697.1">
        <property type="protein sequence ID" value="ENSCJPP00005006126.1"/>
        <property type="gene ID" value="ENSCJPG00005005740.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01020000230364"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036117">
        <property type="term" value="C:hyaluranon cable"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052757">
        <property type="term" value="F:chondroitin hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004415">
        <property type="term" value="F:hyalurononglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051216">
        <property type="term" value="P:cartilage development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044344">
        <property type="term" value="P:cellular response to fibroblast growth factor stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071347">
        <property type="term" value="P:cellular response to interleukin-1"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071467">
        <property type="term" value="P:cellular response to pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036120">
        <property type="term" value="P:cellular response to platelet-derived growth factor stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071356">
        <property type="term" value="P:cellular response to tumor necrosis factor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071493">
        <property type="term" value="P:cellular response to UV-B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030207">
        <property type="term" value="P:chondroitin sulfate proteoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060272">
        <property type="term" value="P:embryonic skeletal joint morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030214">
        <property type="term" value="P:hyaluronan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030308">
        <property type="term" value="P:negative regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045766">
        <property type="term" value="P:positive regulation of angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045785">
        <property type="term" value="P:positive regulation of cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030307">
        <property type="term" value="P:positive regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900106">
        <property type="term" value="P:positive regulation of hyaluranon cable assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009615">
        <property type="term" value="P:response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000065">
        <property type="entry name" value="Hyaluronidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018155">
        <property type="entry name" value="Hyaluronidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11769">
        <property type="entry name" value="HYALURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11769:SF23">
        <property type="entry name" value="HYALURONIDASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01630">
        <property type="entry name" value="Glyco_hydro_56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00846">
        <property type="entry name" value="GLHYDRLASE56"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0458">Lysosome</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034870154" description="Hyaluronidase" evidence="14">
        <location>
            <begin position="51"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU610713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="514" mass="57103" checksum="BBD141606A3EF61B" modified="2022-01-19" version="1">MLTFGCCLPGPSRHTHTQTRVCSEDGQAATMAPGWLCWALLLLLPAPLRAAGPGPVLVNRPFVTVWNVPSEPCEHEYNISLPLEVFDVVANKEEAFMGQDIALFYSSRLGLFPYYTAQGQPVDGGLPQNASLAAHLQQARRDIEAALPSATAGGLAVIDWEQWRPLWARDWGSMDIYRKKSEELVQQQHPLWPPSRVQEVAQQQYQKAARAFMEQTLQLGEAVRPAAYWGFYGFPDCYNNDFSSPQYNGSCPVLEQQRNQELGWLWNCSRALYPSIYLPQQLQGTNKVLRYVRYRVAEAFAVQKGVLSSAIPVLPYTEIFYDDTSDFLSEDLVNTIGESAAQGAAGIIIWGSSEKCMKLRDYLDGVLGHYIVNVTTSAQLCSHSLCSGNGRCVRREGRLAFLQLDPGHFAINLKAKKPQPMVWLLTANSDVSRLAEDFTCQCYSGWLSCGNNRAPSKGWLCLLSFIRKQAQTELPGEILHSAYLDPSVLCTCTNHTCQTDCTSPGLPAEAEPHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T2Z3</accession>
    <name>A0A8C2T2Z3_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Prolyl 4-hydroxylase subunit alpha-3</fullName>
            <ecNumber evidence="6">1.14.11.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">P4HA3</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-prolyl-[collagen] + 2-oxoglutarate + O2 = trans-4-hydroxy-L-prolyl-[collagen] + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:18945"/>
            <dbReference type="Rhea" id="RHEA-COMP:11676"/>
            <dbReference type="Rhea" id="RHEA-COMP:11680"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:50342"/>
            <dbReference type="ChEBI" id="CHEBI:61965"/>
            <dbReference type="EC" id="1.14.11.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:18946"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="17">Heterotetramer of two alpha-3 chains and two beta chains (the beta chain is the multi-functional PDI).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the P4HA family.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.2" evidence="6"/>
    <dbReference type="RefSeq" id="XP_015708121.1">
        <property type="nucleotide sequence ID" value="XM_015852635.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T2Z3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005010847.1">
        <property type="protein sequence ID" value="ENSCJPP00005006972.1"/>
        <property type="gene ID" value="ENSCJPG00005006443.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107308628"/>
    <dbReference type="KEGG" id="cjo:107308628"/>
    <dbReference type="CTD" id="283208"/>
    <dbReference type="GeneTree" id="ENSGT00940000158967"/>
    <dbReference type="OrthoDB" id="420380at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.620:FF:000013">
        <property type="entry name" value="Prolyl 4-hydroxylase subunit alpha 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000161">
        <property type="entry name" value="prolyl 4-hydroxylase subunit alpha-3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013547">
        <property type="entry name" value="P4H_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059068">
        <property type="entry name" value="TPR_P4H"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF223">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE SUBUNIT ALPHA-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08336">
        <property type="entry name" value="P4Ha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23558">
        <property type="entry name" value="TPR_P4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="11" id="KW-0847">Vitamin C</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="21">
        <location>
            <begin position="487"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="20">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00066245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00070101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00083477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="609" mass="67941" checksum="DE846CF4D45B15A9" modified="2022-01-19" version="1">MGTERIGNRIVIAGLTPARGQPAEPNHTRASQEGPPKPHHHPHHHHHPTTPLIPIPSFRSLPFFLPPTAASGRGMRAVGVLGLGALLAWLPPAHTDTFSALRSVRQARSNEGRLLRRLRAYLREESARLRRLSRFYEKVRALHQDPGASVDNPLLAFSLIKRLSSDWPSVIYSNEATENSHALHVGFQELQGELPGAEDLDGAARALMRLQDVYALSVKGMANGLFQPTSTDRPPLYSPGRRVSLSADDCFHVGKVAYETGDYYHSIAWLEEAVSRFRLSYGSWNPEEERGSLEDALDYLAFSYFMAGNISRALTLSKEFLNYDPSNQRVTRNVAKYKKLLATHGDRMGTPLQRPNATQLQNRDAYEELCQGLGAQMAPEQPSHLGCSYETNGSPYLLLQPAKKETLRLQPYIVLYHDFVSDAEAETIKGLAGPWLQRSVVASGEKQQKVEYRISKSAWLKDTADPVVRALELRMAAITGLDLRPPYAEYLQVVNYGLGGHYEPHFDHATSRKSPLYRMKSGNRIATVMIYLSAVEAGGSTAFIYANFSVPVVKNAALFWWNLRRNGDGDGDTLHAGCPVLAGDKWVANKWIHEYGQEFRRPCSQDPQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T305</accession>
    <name>A0A8C2T305_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Inversin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">INVS</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015710570.1">
        <property type="nucleotide sequence ID" value="XM_015855084.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015710572.1">
        <property type="nucleotide sequence ID" value="XM_015855086.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T305"/>
    <dbReference type="Ensembl" id="ENSCJPT00005011904.1">
        <property type="protein sequence ID" value="ENSCJPP00005007755.1"/>
        <property type="gene ID" value="ENSCJPG00005007060.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107309918"/>
    <dbReference type="KEGG" id="cjo:107309918"/>
    <dbReference type="CTD" id="27130"/>
    <dbReference type="GeneTree" id="ENSGT00940000157688"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000078">
        <property type="entry name" value="Inversin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000082">
        <property type="entry name" value="Inversin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000092">
        <property type="entry name" value="inversin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000134">
        <property type="entry name" value="inversin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000144">
        <property type="entry name" value="inversin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF194">
        <property type="entry name" value="INVERSIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="47"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="80"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="148"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="254"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="288"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="356"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="389"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="422"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="455"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="488"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="589"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="736"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="807"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="876"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1006"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="589"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="623"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="653"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="681"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="812"/>
            <end position="823"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005007755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1105" mass="122711" checksum="377F0F79C3521CF2" modified="2022-01-19" version="1">MNISANCLFSGSSLASEVHAAAVNGDKSTLLKLIAGNSELKDKEDQFGRTPLMYCVLADRVDCAEALLKAGADVNRTDRSRRTALHLAAQKGNYRFMKLLLARRGNWMQKDLEGMTPLHLTTRHKSPKCLALLLKHMAPGEVDTQDRNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDIEGKIPLHWAANNKDPSAIHTVKCILEAAPTESLLNWQDYEGRTPLHFAVADGNVAVVDVLTSYEGCNVTSYDNLFRTPLHWAALLGHAQIVHLLLERNKFGTIPSDSQGATPLHYAAQSNFAETVEVFLKHPSVKDDSDLEGRTSFMWAAGKGSDNVIRTMLDLKLDIDINMTDKYAGTALHAAALSGHVSTVKLLLERNAQVDALDVMKHTPLFRACEMGHKEVIQTLIKGGARVDLVDQDGHSPLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMVVLLENNADPNIQDKEGRTALHWLCNNGYLDAIKLLLGFDAFPNHMENSEERYTPLDYALLGEHHEVIQFMLEHGALSIAAIQDIAAFKIQAVYKGYKVRKAFQERKNLLMKHEQLRKDAAAKKREEESKRKEASLQKGMQNLEQNKCRVQPNTADQEKTTNTLQLSNKQTDLQNKRPLSVSASQIQLGRNSRGSPKACRSKASPKESCLSSEPQSEGHNIRQELLRKHIKSKPSYVHFHCGKAREVMKVEAKHQVAAATKLNGEKHKEHAVETNGASAHGNRRHASACGTDGAGEKARDQSQSSSGNRGHCEGTSVVMCNVSCAGGIARNSKRCEAVPKGKRHQQKSRHKEVKDERCSPAGSSRPGSAKAVFVNTRNATVRAIEHANNVGNELTKKTSLLLSTETESKGTGPRNPATCSAPDDSLNLDKTGEVGSRNADDQLCSVAWQSTNIELIPLEIRMQIIEKERTRKELFRKKNYAATVIQRTWRSYHLRQELSQLLSAKRQRKEDEDKWRQETAAFLIQVAWKKQLNHSPQKSVPSSKNLKSVNKTSSAIKSSKQSILKQIYGRSREGRVFPPARPPSKLKLSDVQLVSVNNLQYVNLLENMGKSKQFSYNMRPSTAAKSTSTRPEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T3M5</accession>
    <name>A0A8C2T3M5_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA polymerase I subunit E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">POLR1E</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPA49/POLR1E RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015705573.1">
        <property type="nucleotide sequence ID" value="XM_015850087.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T3M5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005010509.1">
        <property type="protein sequence ID" value="ENSCJPP00005006717.1"/>
        <property type="gene ID" value="ENSCJPG00005006224.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107306742"/>
    <dbReference type="KEGG" id="cjo:107306742"/>
    <dbReference type="CTD" id="64425"/>
    <dbReference type="GeneTree" id="ENSGT00390000018004"/>
    <dbReference type="OrthoDB" id="532500at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome Z"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001650">
        <property type="term" value="C:fibrillar center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001179">
        <property type="term" value="F:RNA polymerase I general transcription initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001188">
        <property type="term" value="P:RNA polymerase I preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009668">
        <property type="entry name" value="RNA_pol-assoc_fac_A49-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14440">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06870">
        <property type="entry name" value="RNA_pol_I_A49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="413" mass="46870" checksum="F66CC2EB05B75D6F" modified="2022-01-19" version="1">MATATWRYRGDPEQEQPAVLVTFSNGQLQRPDAVRFSLYRSSEVSNPRKRRRRILVSETERLSYVGNNFSSGSMKSNSLCRYFLGVLNKDSGQMEVYNAEIFNMQPLLSDNFIPDDTRDYQNKSYREKMDLCIEAFGTRKQKRALNSRRMNAVGSDILNTAVTKAAADVIDAKGVTALIQDVAQDDEQNMSIFLPPCHEDADKPEHVYKFDDIISPAEYEALQGPAAAFINITPEEIAKKTEEKSHCSFVLEELKFLPADEMSRDHKARCLWFLDILIKFSFLKIIKKKYPMGPECPLIISRKLMKNFTSLTYNNGSVQNLISASLKTKIAAYVIALALHIKNFQVDLTVLQNDLKLHENRLMDIARAMRLKVSKAKGMPGLENDQNHKFGTLSLPLPVQKAPGGWRMGKKMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T443</accession>
    <name>A0A8C2T443_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein eS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">RPS3A</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="6">Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the eukaryotic ribosomal protein eS1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015716608.1">
        <property type="nucleotide sequence ID" value="XM_015861122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T443"/>
    <dbReference type="SMR" id="A0A8C2T443"/>
    <dbReference type="Ensembl" id="ENSCJPT00005009563.1">
        <property type="protein sequence ID" value="ENSCJPP00005006013.1"/>
        <property type="gene ID" value="ENSCJPG00005005669.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107313151"/>
    <dbReference type="KEGG" id="cjo:107313151"/>
    <dbReference type="CTD" id="6189"/>
    <dbReference type="GeneTree" id="ENSGT00390000018433"/>
    <dbReference type="OrthoDB" id="9834376at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048027">
        <property type="term" value="F:mRNA 5'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03122">
        <property type="entry name" value="Ribosomal_eS1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001593">
        <property type="entry name" value="Ribosomal_eS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018281">
        <property type="entry name" value="Ribosomal_eS1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027500">
        <property type="entry name" value="Ribosomal_eS1_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11830">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01015">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01397">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01191">
        <property type="entry name" value="RIBOSOMAL_S3AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="initiator methionine" description="Removed" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="233"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="242"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="264" mass="29867" checksum="C91E3F9BCF5D20EC" modified="2022-01-19" version="1">MAVGKNKRLTKGGKKGAKKKVVDPFSKKDWYDVKAPAMFNIRNIGKTLVTRTQGTKIASDGLKGRVFEVSLADLQNDEVAFRKFKLITEDVQGKNCLTNFHGMDLTRDKMCSMVKKWQTMIEAHVDVKTTDGYLLRLFCVGFTKKRNNQIRKTSYAQHQQVRQIRKKMMEIMTREVQTNDLKEVVNKLIPDSIGKDIEKACQSIYPLHDVYVRKVKMLKKPKFELGKLMELHGEGGGAGKPSGDEAGAKVERADGYEPPVQESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T531</accession>
    <name>A0A8C2T531_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Testis expressed 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TEX10</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the IPI1/TEX10 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T531"/>
    <dbReference type="Ensembl" id="ENSCJPT00005011902.1">
        <property type="protein sequence ID" value="ENSCJPP00005007753.1"/>
        <property type="gene ID" value="ENSCJPG00005007059.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182992"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071339">
        <property type="term" value="C:MLL1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000164">
        <property type="entry name" value="Testis-expressed sequence 10 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024679">
        <property type="entry name" value="Ipi1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057949">
        <property type="entry name" value="TPR_TEX10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056">
        <property type="entry name" value="REGULATOR OF MICROTUBULE DYNAMICS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056:SF2">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12333">
        <property type="entry name" value="Ipi1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25781">
        <property type="entry name" value="TPR_TEX10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pre-rRNA-processing protein Ipi1 N-terminal" evidence="5">
        <location>
            <begin position="140"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="TEX10-like TPR repeats" evidence="6">
        <location>
            <begin position="553"/>
            <end position="922"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005007753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="935" mass="106641" checksum="66F160DA4B734E55" modified="2022-01-19" version="1">MSFLQRVRMTKKRKHQEDFQKVKFKVGKKKPRLENATDTTFKTKAIQIPEQLKEDGMLTAQNRKLNIKDLLSQMHHYSPGVKQNALHGLKDLLSQYPFLIDAHLSNIISEVAAVFTDKDSGVRGAAVHLLQFLASKIRAEQIAPFFPLVSAHLSSAMTHISEGIQEDSLKVLDVLLEAYPALLTDRSSILLKNFVELISHQQLSKRLKSKDKLSWMLSVNPNRRVTSQQWRLNVLIRLKKFLQAVVDGSNEIEDEGLQEQKDSPHSVRSPIFISWKVHANNQQHIHLYENGGLRPKMNSSFRLRSLARVMDSAEKGLSSAENLKGFIEIIIPLLIECWIEASPAQSAPILGNLLESDCQQLMQQVLSIIHLLWKLTKRHDETYRMEVWLRMNYLVDFKHHFMRNFPYSLQETVKHRKKESCKGNKYCMPSSNNVDHLLLNLTLCDIMVSLASASTLQADSGWLDMIRKFVTDTLQDGSRLNSKQVNRLLGVTWRLMQIQQNKVATEPLIKAVYTLYQQRNLLFPVRTLLLKFFSRVYQKEDSKTQRIRSRSKVLSRWLAGLPQQLALLGLRNPELSNQLIDIIHSAASRSNKELLQSLQATAVQIYDPLDGTLVLLPAEAQRRLVQLVYFLPCLPASLLACLSRCCIMGRMSSELAATLIGILRMRSSFAGWKCQVQDNAVNDVDYFSFLFSTLIGFSREELTSLQGIRGKPHISQTQLSPVRLYLTDLDQFLHHWAVTEVICHSLSSIPSQSQCFDILQTGICKYLVGLVVIPDSTAGSVLCAINKLLDQACILSENLHKFLASCCYSLLYFLLTLDKEDAEHVQKRDMLWGSCISALALLPRLLRLMLQSLQVSRICREELPVVAQLLRLLMQHGQLRSHMMTNEFLVQQIIKDIMTLKSGEVQEQWLTDLHYCFNIYLASHPQGPSPMNAVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T5S2</accession>
    <name>A0A8C2T5S2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nuclear factor NF-kappa-B p105 subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">NFKB1</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Constitutes the active form, which associates with RELA/p65 to form the NF-kappa-B p65-p50 complex to form a transcription factor. Together with RELA/p65, binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T5S2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005011788.1">
        <property type="protein sequence ID" value="ENSCJPP00005007653.1"/>
        <property type="gene ID" value="ENSCJPG00005006993.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158625"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033256">
        <property type="term" value="C:I-kappaB/NF-kappaB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035525">
        <property type="term" value="C:NF-kappaB p50/p65 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042805">
        <property type="term" value="F:actinin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140367">
        <property type="term" value="P:antibacterial innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050853">
        <property type="term" value="P:B cell receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007249">
        <property type="term" value="P:canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904385">
        <property type="term" value="P:cellular response to angiotensin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071359">
        <property type="term" value="P:cellular response to dsRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097398">
        <property type="term" value="P:cellular response to interleukin-17"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071354">
        <property type="term" value="P:cellular response to interleukin-6"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071222">
        <property type="term" value="P:cellular response to lipopolysaccharide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071260">
        <property type="term" value="P:cellular response to mechanical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071316">
        <property type="term" value="P:cellular response to nicotine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098586">
        <property type="term" value="P:cellular response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007254">
        <property type="term" value="P:JNK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900016">
        <property type="term" value="P:negative regulation of cytokine production involved in inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050728">
        <property type="term" value="P:negative regulation of inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032695">
        <property type="term" value="P:negative regulation of interleukin-12 production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010957">
        <property type="term" value="P:negative regulation of vitamin D biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038061">
        <property type="term" value="P:non-canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090263">
        <property type="term" value="P:positive regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010875">
        <property type="term" value="P:positive regulation of cholesterol efflux"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900127">
        <property type="term" value="P:positive regulation of hyaluronan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050729">
        <property type="term" value="P:positive regulation of inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010884">
        <property type="term" value="P:positive regulation of lipid storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010744">
        <property type="term" value="P:positive regulation of macrophage derived foam cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000630">
        <property type="term" value="P:positive regulation of miRNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060261">
        <property type="term" value="P:positive regulation of transcription initiation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035994">
        <property type="term" value="P:response to muscle stretch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023019">
        <property type="term" value="P:signal transduction involved in regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033209">
        <property type="term" value="P:tumor necrosis factor-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd08797">
        <property type="entry name" value="Death_NFkB1_p105"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01177">
        <property type="entry name" value="IPT_NFkappaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07935">
        <property type="entry name" value="RHD-n_NFkB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000046">
        <property type="entry name" value="Nuclear factor NF-kappa-B p105 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000103">
        <property type="entry name" value="Nuclear factor NF-kappa-B p105 subunit isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.340:FF:000004">
        <property type="entry name" value="Nuclear factor NF-kappa-B p105 subunit isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.340">
        <property type="entry name" value="Rel homology domain (RHD), DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033926">
        <property type="entry name" value="IPT_NFkappaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047096">
        <property type="entry name" value="NF-kB_p105_DD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030503">
        <property type="entry name" value="NF-kB_p105_RHD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000451">
        <property type="entry name" value="NFkB/Dor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030492">
        <property type="entry name" value="RHD_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032397">
        <property type="entry name" value="RHD_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011539">
        <property type="entry name" value="RHD_DNA_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037059">
        <property type="entry name" value="RHD_DNA_bind_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24169:SF9">
        <property type="entry name" value="NUCLEAR FACTOR NF-KAPPA-B P105 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24169">
        <property type="entry name" value="NUCLEAR FACTOR NF-KAPPA-B PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16179">
        <property type="entry name" value="RHD_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00554">
        <property type="entry name" value="RHD_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00057">
        <property type="entry name" value="NFKBTNSCPFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00005">
        <property type="entry name" value="DEATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00429">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01204">
        <property type="entry name" value="REL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50254">
        <property type="entry name" value="REL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0010">Activator</keyword>
    <keyword evidence="10 17" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0702">S-nitrosylation</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="RHD" evidence="19">
        <location>
            <begin position="173"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="17">
        <location>
            <begin position="695"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="17">
        <location>
            <begin position="728"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="17">
        <location>
            <begin position="764"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="17">
        <location>
            <begin position="798"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="17">
        <location>
            <begin position="832"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="52"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="538"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="18">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="152"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="544"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00045986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005007653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1098" mass="119536" checksum="5818DDA03EDC745A" modified="2022-01-19" version="1">MARYYVSRLTFLRAYFPLWGFLSVRRSAPTPAAPHLPRAALRPRARGTIRPPAAARCLPFPPRPGCPARPSQRQREFPVRKCGGPGAGAERSGGKGRQAAAARAGVPLGCPRQRAGGGAAGGKNGGKSARSRGSGGVTPLIWRGAEGCAAGTRRRPRRRRRRGCPSPSPALSQRGFRFRYVCEGPSHGGLPGASSEKNKKSYPQVKICNYVGPAKVIVQLVTNGKYVHLHAHSLVGKFCEDGVCTVNAGPKDMVVGFANLGILHVTKKKVFETLETRMIDACKKGYNPGLLVHPELGYLQAEGCGDRQLTEREREIIRQAAVQQTKEMDLSVVRLMFTAFLPDSNGGFTRRLDPVISDAIYDSKAPNASNLKIVRMDRTAGCVTGGEEIYLLCDKVQKDDIQIRFYEEDENGGMWEGFGDFSPTDVHRQFAIVFKTPKYRDVNITKPASVFVQLRRKSDLETSEPKPFLYYPEIKDKEEVQRKRQKLMPNFSDGYGGGSGAGGGGMFGGGGGGAGSGFSYPSYGYPAFGGMHFHPGTTKSNAGMKHELSSSTVEKHEESSDKQSDKWDTKHDVKVETMEKNECRTSGHNEEKEDTSLCCKDEGNKAKCGCQDGLFLEKAMQLAKRHCNALFDYAITGDVRMLLAVQRHLTAVQDDNGDNVLHLSIIHLHRELVKNLLEVMPDMNYNNIINMRNDLYQTPLHLAVITKQAEVVEDLLKAGANVNLLDRHGNSVLHLAAAEGDDKILGLLLKHKKASSMIDLSNGEGLSAIHMVVIANSLSCLKLLLAAGVNVNAQEQKSGRTALHLAVEQENIPLAGCLLLEGDADVDSTTYDGTTPLHIAAGRGFTKLAAVLKAAGADPHIENFEPLFDVEEDVKDDDDEGIVPGTTPLDMAANWEVYDILNGKPYIAAAAVSEDLLTQGPLRELNESSKQQLYKLLETPDPSKNWATLAEKLGLGILNNAFGLSPSPSKTLLDNYKISGGTVQELIAALRQMDHTEAIEVIQKALSSSQRQSHQEDNAIEAFPSSSLANFAKGETGELYNHKFQDTESTCDSGVETSFRKLSFTYSDSLNSKSSVTLSKMTLGYGQESSVQGNYIPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T5T4</accession>
    <name>A0A8C2T5T4_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Microfibril-associated glycoprotein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">MFAP3</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the elastin-associated microfibrils.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015731269.1">
        <property type="nucleotide sequence ID" value="XM_015875783.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015731270.1">
        <property type="nucleotide sequence ID" value="XM_015875784.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015731271.1">
        <property type="nucleotide sequence ID" value="XM_015875785.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T5T4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005012158.1">
        <property type="protein sequence ID" value="ENSCJPP00005007936.1"/>
        <property type="gene ID" value="ENSCJPG00005007199.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107320169"/>
    <dbReference type="KEGG" id="cjo:107320169"/>
    <dbReference type="CTD" id="4238"/>
    <dbReference type="GeneTree" id="ENSGT00390000011576"/>
    <dbReference type="OrthoDB" id="8611351at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14340">
        <property type="entry name" value="MICROFIBRIL-ASSOCIATED GLYCOPROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14340:SF4">
        <property type="entry name" value="MICROFIBRIL-ASSOCIATED GLYCOPROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="3 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034572937" description="Microfibril-associated glycoprotein 3" evidence="10">
        <location>
            <begin position="20"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="44"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="284"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="321"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005007936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="341" mass="37680" checksum="991DF280D5CF718F" modified="2022-01-19" version="1">MKLSYCLLILTVSADLSIGFTLENVASNGTLASESFNTSLHPVPQALASSPAHHDIIAKEGTSILIECKVNISQYEYILWYNSKGRLLQQKDEGGRWRIADNFLNITKVNFADRGRYTCAAISGNNTVYSTVTLRVTFTSGDMSIYYMIVCLVAFAITLILNITRLCMMSSHLRKTEKAINEFFRTEGAEKLQKAFEIAKRIPIITSAKTLELAKVTQFKTMEFARYIEELARSIPLPPLILNCRAFMEEIFEAVRVDDPDEVGEAEKQTQACGAPAAIYPINPEIKRSDSPAGDSDDGSVNEQGQEIAVQVSIHPQAEAQSIDTVSHDSCQFAPSEEGTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T625</accession>
    <name>A0A8C2T625_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SURF1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">SURF1</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Probably involved in the biogenesis of the COX complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Mitochondrion inner membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the SURF1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T625"/>
    <dbReference type="Ensembl" id="ENSCJPT00005011639.1">
        <property type="protein sequence ID" value="ENSCJPP00005007530.1"/>
        <property type="gene ID" value="ENSCJPG00005006886.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000064194"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd06662">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002994">
        <property type="entry name" value="Surf1/Shy1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045214">
        <property type="entry name" value="Surf1/Surf4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427:SF2">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02104">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50895">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005007530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="277" mass="31544" checksum="6B0DF7A3508FD470" modified="2022-01-19" version="1">SSLLYQLTAMGKASRYVCLRLCSPRSSTAATGASSEDIWLKWGLLLVPLTAFCLGTWQIQRRKWKLDLIAQLASRLSSEPIPLTLDPMELKELEYRPVKVRGHFDHSKELYILPRSLVDPEREAREAGRLTSHAENGANVITPFYCTDLGVTILVNRGFVPKKKLKPETRLKGQIEEEIDLTGVVRLSEKRKPFVPENNAEKNRWHYRDLEAMAKVTGAEPIFIDADFRSTVPGGPIGGQTRVSLRNEHMQYIITWYGLCAATSFLWYRKFIRKVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T769</accession>
    <name>A0A8C2T769_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C-C motif chemokine</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">CCL20</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the intercrine beta (chemokine CC) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T769"/>
    <dbReference type="Ensembl" id="ENSCJPT00005013743.1">
        <property type="protein sequence ID" value="ENSCJPP00005009177.1"/>
        <property type="gene ID" value="ENSCJPG00005008108.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000287058"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008009">
        <property type="term" value="F:chemokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01119">
        <property type="entry name" value="Chemokine_CC_DCCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.40:FF:000012">
        <property type="entry name" value="C-C motif chemokine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039809">
        <property type="entry name" value="Chemokine_b/g/d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000827">
        <property type="entry name" value="Chemokine_CC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034133">
        <property type="entry name" value="Chemokine_CC_DCCL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001811">
        <property type="entry name" value="Chemokine_IL8-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036048">
        <property type="entry name" value="Interleukin_8-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12015:SF108">
        <property type="entry name" value="C-C MOTIF CHEMOKINE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12015">
        <property type="entry name" value="SMALL INDUCIBLE CYTOKINE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00048">
        <property type="entry name" value="IL8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00199">
        <property type="entry name" value="SCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54117">
        <property type="entry name" value="Interleukin 8-like chemokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00472">
        <property type="entry name" value="SMALL_CYTOKINES_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="4 9" id="KW-0202">Cytokine</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0395">Inflammatory response</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Chemokine interleukin-8-like" evidence="10">
        <location>
            <begin position="16"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005009177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="138" mass="15737" checksum="50C3A74321E14337" modified="2022-01-19" version="1">MVFVDITLSFFPAQSNQDCCLSYTKARLPRKVIKGFTEQLSGEVCDIDAIIFHTNRGLKACVNPKEDWVKKHLLFLRYESQYLNTTRLRQSMSRSLSLAPPHLLRASSELRHSTSCHTCLFLFRVLIGLVISFVPSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T958</accession>
    <name>A0A8C2T958_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin-conjugating enzyme E2 G1</fullName>
            <ecNumber evidence="2">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">E2 ubiquitin-conjugating enzyme G1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Ubiquitin carrier protein G1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Ubiquitin-protein ligase G1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">UBE2G1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. May be involved in degradation of muscle-specific proteins. Mediates polyubiquitination of CYP3A4.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="2"/>
    <dbReference type="RefSeq" id="XP_015736090.1">
        <property type="nucleotide sequence ID" value="XM_015880604.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T958"/>
    <dbReference type="SMR" id="A0A8C2T958"/>
    <dbReference type="Ensembl" id="ENSCJPT00005015135.1">
        <property type="protein sequence ID" value="ENSCJPP00005010174.1"/>
        <property type="gene ID" value="ENSCJPG00005008909.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107322507"/>
    <dbReference type="KEGG" id="cjo:107322507"/>
    <dbReference type="CTD" id="7326"/>
    <dbReference type="GeneTree" id="ENSGT00940000155228"/>
    <dbReference type="OrthoDB" id="19692at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070936">
        <property type="term" value="P:protein K48-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070534">
        <property type="term" value="P:protein K63-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd23795">
        <property type="entry name" value="UBCc_UBE2G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000018">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 13" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="14">
        <location>
            <begin position="5"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="12">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00053162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00073288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00076339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00079259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00079960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005010174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="170" mass="19509" checksum="36B61766D995B332" modified="2022-01-19" version="1">MTELQSALLLRRQLAELNKNPVEGFSAGLIDDNDLYRWEVLIIGPPDTLYEGGVFKAHLTFPKDYPLRPPKMKFITEIWHPNVDKNGDVCISILHEPGEDKYGYEKPEERWLPIHTVETIMISVISMLADPNGDSPANVDAAKEWREDRNGEFKRKVARCVRKSQETAFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T9K4</accession>
    <name>A0A8C2T9K4_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Divergent protein kinase domain 1A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">DIPK1A</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DIPK family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T9K4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005013842.1">
        <property type="protein sequence ID" value="ENSCJPP00005009251.1"/>
        <property type="gene ID" value="ENSCJPG00005008158.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000006452"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022049">
        <property type="entry name" value="FAM69_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029244">
        <property type="entry name" value="FAM69_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21093:SF4">
        <property type="entry name" value="DIVERGENT PROTEIN KINASE DOMAIN 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21093">
        <property type="entry name" value="DIVERGENT PROTEIN KINASE DOMAIN 1C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12260">
        <property type="entry name" value="PIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14875">
        <property type="entry name" value="PIP49_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01299">
        <property type="entry name" value="PIP49_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="FAM69 N-terminal" evidence="10">
        <location>
            <begin position="15"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005009251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="424" mass="48844" checksum="459B4294F4A1A1C7" modified="2025-10-08" version="2">MEERTADGVWLKRIVRFSYMRMKYLFISWLVVFIGSWVMYVQYSTYTELCRGHDCRKIICDKYKTGVIDGSACSSLCAKETLYFGKCLSTKPNNQMYLGIWGNLQGVIKCQMEEAAHLDFGTDPEPRKEVILFDKPTRGTTVEKFKEMVYGFFKAKLGEQGNLSELVNVILSFADGNRDGRVSLPEAKSAWALLQLDEFMLMVMLQGKEHTPKLMGFCGDLYVTERVEYTSLYGISLPWVIELLIPSGFRRSMDQWFTPSWPRKAKIAIGLLEFVEDIFHGPYGNFLMCDTSAKNLGYNDKYDLKMMDMRKIVPEMNLKEMIKDRPCESDMDCVYGTDCRTLCDQSKMRCTTEVIQPNLAKVCQLLKDYLLRGAPADIHEELEKQLYLCIALKVSANQMEMEHSLILNNLKTLLWKKISHTTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TAE9</accession>
    <name>A0A8C2TAE9_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 15">Ribonuclease H1</fullName>
            <shortName evidence="15">RNase H1</shortName>
            <ecNumber evidence="6 15">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">RNASEH1</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. Plays a role in RNA polymerase II (RNAp II) transcription termination by degrading R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site and behind the elongating RNAp II.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the RNase H family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="6 15"/>
    <dbReference type="RefSeq" id="XP_015714864.1">
        <property type="nucleotide sequence ID" value="XM_015859378.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TAE9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005014570.1">
        <property type="protein sequence ID" value="ENSCJPP00005009798.1"/>
        <property type="gene ID" value="ENSCJPG00005008569.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107312176"/>
    <dbReference type="KEGG" id="cjo:107312176"/>
    <dbReference type="CTD" id="246243"/>
    <dbReference type="GeneTree" id="ENSGT00390000003466"/>
    <dbReference type="OrthoDB" id="407198at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09280">
        <property type="entry name" value="RNase_HI_eukaryote_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000049">
        <property type="entry name" value="Ribonuclease H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.970.10:FF:000001">
        <property type="entry name" value="Ribonuclease H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.970.10">
        <property type="entry name" value="Ribonuclease H1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_bL9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050092">
        <property type="entry name" value="RNase_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017067">
        <property type="entry name" value="RNase_H1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011320">
        <property type="entry name" value="RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037056">
        <property type="entry name" value="RNase_H1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642:SF26">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01693">
        <property type="entry name" value="Cauli_VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036852">
        <property type="entry name" value="Ribonuclease_H1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="L9 N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 15" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 15" id="KW-0540">Nuclease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034226952" description="Ribonuclease H1" evidence="17">
        <location>
            <begin position="21"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="RNase H type-1" evidence="18">
        <location>
            <begin position="143"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="66"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00068459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR036852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005009798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="293" mass="32300" checksum="790FA176E2049726" modified="2022-01-19" version="1">MLRWLVALLSHSCFVSKGGGMFYAVRKGRQTGVYRTWAECQQQVNRFPSASFKKFATEKEAWAFVGAGPPGGQQSAPAETPGASAVTQEDGSQREEPGTDVVCCNACKRPYEQPTNEEHTVKRAKHDEGHSTPIVSEDKFSYMGEFAVVYTDGCCSGNGRNRARAGIGVYWGPGHPLNISERLPGRQTNQRAEIHAACKAIEQAKSQNIKKLIIYTDSKFTINGITSWVENWKTNGWRTSSGGSVINKEDFQKLDSLSQGIEIQWMHIPGHAGFQGNEEADRLAREGASKQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TAY7</accession>
    <name>A0A8C2TAY7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Glycerol kinase 5</fullName>
            <ecNumber evidence="4">2.7.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP:glycerol 3-phosphotransferase 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">GK5</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Skin-specific kinase that plays a key role in glycerol metabolism, catalyzing its phosphorylation to produce sn-glycerol 3-phosphate. Involved in skin-specific regulation of sterol regulatory element-binding protein (SREBP) processing and lipid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.30" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2TAY7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005016176.1">
        <property type="protein sequence ID" value="ENSCJPP00005011023.1"/>
        <property type="gene ID" value="ENSCJPG00005009331.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01000000214434"/>
    <dbReference type="UniPathway" id="UPA00618">
        <property type="reaction ID" value="UER00672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004370">
        <property type="term" value="F:glycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046167">
        <property type="term" value="P:glycerol-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07793">
        <property type="entry name" value="ASKHA_NBD_FGGY_GK5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000102">
        <property type="entry name" value="Putative glycerol kinase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000104">
        <property type="entry name" value="putative glycerol kinase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037444">
        <property type="entry name" value="GK5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196:SF68">
        <property type="entry name" value="GLYCEROL KINASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="8 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="15">
        <location>
            <begin position="20"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="16">
        <location>
            <begin position="290"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005011023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="524" mass="58157" checksum="3ED929429FE34B47" modified="2022-01-19" version="1">TKLECLSRVKRIQHAAPALYVVGVDVGSTAVKCHVYDRGAAVRGSSCRKVESLYPRPGWVELDPEVLWSQFVGVVKEAVQAAGIHMKQVAALGISTQRSTFITWHKRTGKPFHNFISWQDLRSAELVNSWNRSLLLKVIHVIFTVLHFFTGNDRYLAPSFLTFSTHQTSMKLSWVFKNIPEVTAKKNNCCFGTVDTWLLYRLTKGSVFATDYSNASSTGVFEPFTKCWNPTLCSLLSIPMSIYPPVKDTSFNFGSADPEIFGVPIPIMALVADQQSAMFGECCFQPGDVKLTMGTGGFWNVNTGGSLFASHRGLYPLIGWKIGEEVVYLTEGSVSNIGTTIKWAQDINLFTSVDETAKMARSIVDSQGVCFVPGFQVSANNSSLCASFMGLKPTTTRNHLVRAILESVAFRNKQLFDIIVKKVRIPLRTVRADGGVSNNSFVMQMTSDLINKKIEKPSNTDMSSLGAAFLAGLASGLWTDKEQLKKLRRIEAVFEPQKDVKEYKPAMDTWMQAVKSDVYNRSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TC75</accession>
    <name>A0A8C2TC75_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">N(4)-(Beta-N-acetylglucosaminyl)-L-asparaginase</fullName>
            <ecNumber evidence="7">3.5.1.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Aspartylglucosaminidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Glycosylasparaginase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">N4-(N-acetyl-beta-glucosaminyl)-L-asparagine amidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">AGA</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Cleaves the GlcNAc-Asn bond which joins oligosaccharides to the peptide of asparagine-linked glycoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O = N-acetyl-beta-D-glucosaminylamine + L-aspartate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11544"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15947"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:58080"/>
            <dbReference type="EC" id="3.5.1.26"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Ntn-hydrolase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.26" evidence="7"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2TC75"/>
    <dbReference type="Ensembl" id="ENSCJPT00005016824.1">
        <property type="protein sequence ID" value="ENSCJPP00005011505.1"/>
        <property type="gene ID" value="ENSCJPG00005009890.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183045"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003948">
        <property type="term" value="F:N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04513">
        <property type="entry name" value="Glycosylasparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.30:FF:000003">
        <property type="entry name" value="N(4)-(Beta-N-acetylglucosaminyl)-L-asparaginase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.30">
        <property type="entry name" value="(Glycosyl)asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000246">
        <property type="entry name" value="Peptidase_T2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188:SF6">
        <property type="entry name" value="N(4)-(BETA-N-ACETYLGLUCOSAMINYL)-L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01112">
        <property type="entry name" value="Asparaginase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034877224" description="N(4)-(Beta-N-acetylglucosaminyl)-L-asparaginase" evidence="16">
        <location>
            <begin position="21"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="13">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="231"/>
            <end position="234"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="254"/>
            <end position="257"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="15">
        <location>
            <begin position="202"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00050421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00053295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00066729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00067727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00078726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00079301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00080645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005011505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="371" mass="40065" checksum="C9B040BDFCC1B2A6" modified="2022-01-19" version="1">MAPVVRFLLIALQLVGPCGAAGAALPLVINTWAFRKATETAWRTLQLGGSELDAVEKGCGQCEVDQCDGSVGYGGSPDESGETTLDAMIMDGNTMEVGAVADLRHVKNAIGVARKVIEHTKHTLLVGESATLFAVRMGFPYEDLTTQRSLSIYSRWLNQSCQPNYWKNVVPDSSKSCGPYKRLEKVSFDEGTISQRNIHSHDTIGMVVIGKSGTVASGTSTNGGVHKIPGRVGDSPIAGAGSYADSTAGGAAATGDGDTMMRFLPSYQAVEYMRMGTDPTVACQKVISRIQKHVPEFFGAVICANTTGSYGVKDLAFTIGRLIYHEGKLHHQMITRDYKKSCKQPLEEKENQLHHIDKNVTCDFIWGKKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TCN8</accession>
    <name>A0A8C2TCN8_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Tumor protein p73</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">TP73</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12 14">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Found in a complex with p53/TP53 and CABLES1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 14">Belongs to the p53 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015738033.1">
        <property type="nucleotide sequence ID" value="XM_015882547.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TCN8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005015904.1">
        <property type="protein sequence ID" value="ENSCJPP00005010805.1"/>
        <property type="gene ID" value="ENSCJPG00005009350.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107323447"/>
    <dbReference type="CTD" id="7161"/>
    <dbReference type="GeneTree" id="ENSGT00950000183153"/>
    <dbReference type="OrthoDB" id="5915660at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030054">
        <property type="term" value="C:cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097371">
        <property type="term" value="F:MDM2/MDM4 family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002039">
        <property type="term" value="F:p53 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061629">
        <property type="term" value="F:RNA polymerase II-specific DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033326">
        <property type="term" value="P:cerebrospinal fluid secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048546">
        <property type="term" value="P:digestive tract morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030900">
        <property type="term" value="P:forebrain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042771">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060044">
        <property type="term" value="P:negative regulation of cardiac muscle cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043524">
        <property type="term" value="P:negative regulation of neuron apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048666">
        <property type="term" value="P:neuron development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045793">
        <property type="term" value="P:positive regulation of cell size"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902167">
        <property type="term" value="P:positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901248">
        <property type="term" value="P:positive regulation of lung ciliated cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051262">
        <property type="term" value="P:protein tetramerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001836">
        <property type="term" value="P:release of cytochrome c from mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd08367">
        <property type="entry name" value="P53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09571">
        <property type="entry name" value="SAM_tumor-p73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.720:FF:000002">
        <property type="entry name" value="Cellular tumor antigen p53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000020">
        <property type="entry name" value="Tumor protein 63 (p63)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.170.10">
        <property type="entry name" value="p53-like tetramerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012346">
        <property type="entry name" value="p53/RUNT-type_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057064">
        <property type="entry name" value="P53_central_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011615">
        <property type="entry name" value="p53_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036674">
        <property type="entry name" value="p53_tetramer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010991">
        <property type="entry name" value="p53_tetrameristn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002117">
        <property type="entry name" value="p53_tumour_suppressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037612">
        <property type="entry name" value="Tumour-p73_SAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11447">
        <property type="entry name" value="CELLULAR TUMOR ANTIGEN P53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11447:SF21">
        <property type="entry name" value="TUMOR PROTEIN P73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00870">
        <property type="entry name" value="P53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07710">
        <property type="entry name" value="P53_tetramer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00386">
        <property type="entry name" value="P53SUPPRESSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47719">
        <property type="entry name" value="p53 tetramerization domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00348">
        <property type="entry name" value="P53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0010">Activator</keyword>
    <keyword evidence="3 14" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="4 12 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 14" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="5 12 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SAM" evidence="16">
        <location>
            <begin position="509"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="98"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="340"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="420"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="98"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="340"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="493"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="13">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602117-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602117-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005010805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="656" mass="72790" checksum="A8E6D08D2F60E34E" modified="2022-01-19" version="1">MKDWRWIPLQKVIYPLSDSPSVKMSQSSPADESTTFEHLWSTLAPDSTYFDLSPSSHTGSNEVSNSTEVSMDVFQMRGMNDSVMSQFNLLNNSMDQSIGSRAASTSPYSSEHTSNVPTHSPYSQPSSTFDAMSPAPVIPSNTDYPGPHHFEVTFQQSSTAKSATWTYSPLLKKLYCQIAKTCPIQIKVSSPPPPGTIIRAMPVYKKAEHVTEVVKRCPNHELGRDFNDGQSAPASHLIRVEGNNLSQYVDDPVTGRQSVMVPYEPPQVGTEFTTILYNFMCNSSCVGGMNRRPILIIITLETRDGQVLGRRSFEGRICACPGRDRKADEDHYREQQALNENAAKNGNANKRTFKQSPQAIPALGPGVKKRRHGEEEMYYVPVRGRENFEILMKIKESLELVELVPQQLVDSYRQQQQQLLQRQNQLQTPSSYGPVLSPMNKVHGGGINKLPSVNQLVGQPAQHSSSSAPSLGPMGPGMLNSHPMQPNGEMNGGHSSQSMVSGSHCTPPPPYNPDPSLVSFLTGLGCPNCIDYFTSQGLQNIYHLQNLSMEDLGALKIPEQYRMIIWRGLQELKQSHDYGAQQLIRSSSNASTISIGSSGELQRQRVMEAVHFRVRHTITIPNRGAADEWADFGFDLPDCKSRKQSIKEEFTEGEIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TF39</accession>
    <name>A0A8C2TF39_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Centrosomal protein of 44 kDa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">CEP44</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Centriole-enriched microtubule-binding protein involved in centriole biogenesis. In collaboration with CEP295 and POC1B, is required for the centriole-to-centrosome conversion by ensuring the formation of bona fide centriole wall. Functions as a linker component that maintains centrosome cohesion. Associates with CROCC and regulates its stability and localization to the centrosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Spindle pole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Midbody</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015717196.1">
        <property type="nucleotide sequence ID" value="XM_015861710.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015717197.1">
        <property type="nucleotide sequence ID" value="XM_015861711.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TF39"/>
    <dbReference type="Ensembl" id="ENSCJPT00005016897.1">
        <property type="protein sequence ID" value="ENSCJPP00005011555.1"/>
        <property type="gene ID" value="ENSCJPG00005009932.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107313454"/>
    <dbReference type="KEGG" id="cjo:107313454"/>
    <dbReference type="CTD" id="80817"/>
    <dbReference type="GeneTree" id="ENSGT00390000009873"/>
    <dbReference type="OrthoDB" id="259598at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007099">
        <property type="term" value="P:centriole replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010457">
        <property type="term" value="P:centriole-centriole cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033603">
        <property type="entry name" value="CEP44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029157">
        <property type="entry name" value="CEP44_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31477">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 44 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31477:SF1">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 44 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15007">
        <property type="entry name" value="CEP44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centrosomal CEP44" evidence="10">
        <location>
            <begin position="5"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="174"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="298"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="187"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="299"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF15007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005011555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="381" mass="43648" checksum="9EE888BF898A51CD" modified="2022-01-19" version="1">MTTGDLKGSLRKIEQGLRMINYPRDVDYTVLVKGDPAAFLPIISYSFTSFSTYIAELLVKCDVELTAKSDLRFIEAIYKLLRDQFHYKPILTKEQFLQFGFAERKMQIVCDIINCVVKKHKELSKLNKVKSQTRKKFRPSKREIWSNCGNVLVDLSGTLNSKQRVQKMPLVERHSGDEVSDELPLAPINPTPLNPPSLPAEGDNEEELVLDDDVEEVKCEQVIEGNSQMELLQHQLADCQEKLHKLDWMEDKLRVLEERLKGKVIIDEKDWYNLLSRVLLLETELLLQSKKRDLPAEFNSVSQDGTPSITPVSPDAEKKEEMTECPRQLSRCSSLLSTVSFPKAVTEISKETTRQRMERISKIIEETTELLKTSSNTSEKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TG66</accession>
    <name>A0A8C2TG66_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Store-operated calcium entry-associated regulatory factor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Transmembrane protein 66</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">SARAF</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SARAF family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TG66"/>
    <dbReference type="Ensembl" id="ENSCJPT00005018104.1">
        <property type="protein sequence ID" value="ENSCJPP00005012495.1"/>
        <property type="gene ID" value="ENSCJPG00005010625.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000013419"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140268">
        <property type="term" value="C:endoplasmic reticulum-plasma membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006816">
        <property type="term" value="P:calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001256">
        <property type="term" value="P:regulation of store-operated calcium entry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009567">
        <property type="entry name" value="SARAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15929">
        <property type="entry name" value="STORE-OPERATED CALCIUM ENTRY-ASSOCIATED REGULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15929:SF0">
        <property type="entry name" value="STORE-OPERATED CALCIUM ENTRY-ASSOCIATED REGULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06682">
        <property type="entry name" value="SARAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16" id="KW-0732">Signal</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034321222" description="Store-operated calcium entry-associated regulatory factor" evidence="16">
        <location>
            <begin position="24"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="188"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005012495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="312" mass="34010" checksum="D73DCD9552B8A473" modified="2022-01-19" version="1">MAMERGVVVLFLLLCAAASATWGWDQQGVLLRDVQVLTLYRGRYTTARRTAAVPQLQCTGGSAGCSDIPEVVQCYNRGWDGHDVQWQCKADLDSTLRFGQIEVSCEGYNYPDDPYILKGSCSLLFRLELTKEGERKAKNFGGFGSGYYTSTKDSSDSGAGAIFVIVLLILAFGVYKFFLSNQQPQQGFGDSDGFTPPSWQSHQAPPPPGFKSSFTEDNGFGTRSSHETNSGPGFWTGLGAGGLLGYLAGSQRAQPRSSYFSTWGDPTAVPPMHRQCSNSTQGSSTRTASETEQHCVETYTEHCITCIRVVFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TG83</accession>
    <name>A0A8C2TG83_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Protein CCSMST1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the UQCC4 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TG83"/>
    <dbReference type="Ensembl" id="ENSCJPT00005017483.1">
        <property type="protein sequence ID" value="ENSCJPP00005012023.1"/>
        <property type="gene ID" value="ENSCJPG00005010259.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000235280"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029160">
        <property type="entry name" value="UQCC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023248">
        <property type="entry name" value="UQCC4_vert"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35268">
        <property type="entry name" value="PROTEIN CCSMST1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35268:SF1">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME-C REDUCTASE COMPLEX ASSEMBLY FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15013">
        <property type="entry name" value="CCSMST1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02042">
        <property type="entry name" value="CCSMST1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005012023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="174" mass="18315" checksum="1C75F655F29F1DA6" modified="2022-01-19" version="1">MAVVVTGYELCGYSSSVYRDSTGRSPVTVETFCVEPGANSVSFPPPLPAVHLRVPVAPPCGLLAITACSAMVAFPLPGGAGAERCDELGDEGAIPFSASKASPRVWSVSQSMGSDYERSWVKVLPVSLLCSGLLLWCVFREKTEIDDKLEALFSGEMLDPSDASPRTPSNASAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TGI5</accession>
    <name>A0A8C2TGI5_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Ceramide synthase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">CERS1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>sphinganine + octadecanoyl-CoA = N-(octadecanoyl)-sphinganine + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36547"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57394"/>
            <dbReference type="ChEBI" id="CHEBI:57817"/>
            <dbReference type="ChEBI" id="CHEBI:67033"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:36548"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TGI5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005019179.1">
        <property type="protein sequence ID" value="ENSCJPP00005013333.1"/>
        <property type="gene ID" value="ENSCJPG00005011264.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234515"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050291">
        <property type="term" value="F:sphingosine N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072721">
        <property type="term" value="P:cellular response to dithiothreitol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036146">
        <property type="term" value="P:cellular response to mycotoxin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071492">
        <property type="term" value="P:cellular response to UV-A"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046325">
        <property type="term" value="P:negative regulation of D-glucose import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901526">
        <property type="term" value="P:positive regulation of mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016439">
        <property type="entry name" value="Lag1/Lac1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560:SF58">
        <property type="entry name" value="CERAMIDE SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560">
        <property type="entry name" value="LONGEVITY ASSURANCE FACTOR 1 LAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034623866" evidence="10">
        <location>
            <begin position="22"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="11">
        <location>
            <begin position="122"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005013333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="360" mass="41832" checksum="41A1E307C1B4BA47" modified="2022-01-19" version="1">MPWTPVQHFRLLFVLVGCVVSEIRRSHLDPSAGAMRGYEPMPGYGQLLHRGYGSLAAAVRGCSDCGWELSRRTWAENANLRWGEVLLCGLCALGWTVLRRAAARRVFRPFGEWCKLQPKDAAKMPESAWKLLFYTISWSYGFYLLFCTEYPFFYDPPSVFYDWKKGMDVPTDIAIAYLLQCSFYGHSIYATAYMDTWRKDSVVMLLHHVVALTLIAFSYVFRYHNVGILVLFLHDINDVQLEFTKLNVYFKHRGGVYHRLNDVISNIGCLTFSVSWFWFRLYWFPLKVLYATCYSSLQSVPNIPFYFFFNALLLVLTLLYIVLFVAKVLMGQVHEVNDVREYDVEDSKKTTNGLVKDKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TI91</accession>
    <name>A0A8C2TI91_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Neurocan core protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Chondroitin sulfate proteoglycan 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="primary">NCAN</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="27" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="27" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">May modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion molecules (NG-CAM and N-CAM). Chondroitin sulfate proteoglycan; binds to hyaluronic acid.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015742252.1">
        <property type="nucleotide sequence ID" value="XM_015886766.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TI91"/>
    <dbReference type="Ensembl" id="ENSCJPT00005019045.1">
        <property type="protein sequence ID" value="ENSCJPP00005013217.1"/>
        <property type="gene ID" value="ENSCJPG00005011168.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107325659"/>
    <dbReference type="CTD" id="1463"/>
    <dbReference type="GeneTree" id="ENSGT00940000158649"/>
    <dbReference type="OrthoDB" id="441660at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072534">
        <property type="term" value="C:perineuronal net"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0005540">
        <property type="term" value="F:hyaluronic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:central nervous system development"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:glial cell differentiation"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0002052">
        <property type="term" value="P:positive regulation of neuroblast proliferation"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001501">
        <property type="term" value="P:skeletal system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
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    <dbReference type="CDD" id="cd03517">
        <property type="entry name" value="Link_domain_CSPGs_modules_1_3"/>
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    </dbReference>
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        <property type="entry name" value="Link_domain_CSPGs_modules_2_4"/>
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        <property type="entry name" value="Aggrecan core protein"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="2.10.25.10:FF:000012">
        <property type="entry name" value="Delta-like protein"/>
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        <property type="entry name" value="Hyaluronan proteoglycan link protein 1"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="2.60.40.10:FF:000571">
        <property type="entry name" value="Neurocan core protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.70.10:FF:000003">
        <property type="entry name" value="Versican core protein"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.10.100.10:FF:000003">
        <property type="entry name" value="Versican core protein"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Versican core protein-like isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050691">
        <property type="entry name" value="Hyaluronan_bind_Proteoglycan"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000538">
        <property type="entry name" value="Link_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22804">
        <property type="entry name" value="AGGRECAN/VERSICAN PROTEOGLYCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22804:SF24">
        <property type="entry name" value="NEUROCAN CORE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00193">
        <property type="entry name" value="Xlink"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01265">
        <property type="entry name" value="LINKMODULE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00445">
        <property type="entry name" value="LINK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01241">
        <property type="entry name" value="LINK_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50963">
        <property type="entry name" value="LINK_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="11 17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 17" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6" id="KW-0430">Lectin</keyword>
    <keyword evidence="10" id="KW-0654">Proteoglycan</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 21" id="KW-0732">Signal</keyword>
    <keyword evidence="4 18" id="KW-0768">Sushi</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033990610" description="Neurocan core protein" evidence="21">
        <location>
            <begin position="26"/>
            <end position="1271"/>
        </location>
    </feature>
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        <location>
            <begin position="20"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Link" evidence="26">
        <location>
            <begin position="160"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Link" evidence="26">
        <location>
            <begin position="261"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="957"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="995"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="23">
        <location>
            <begin position="1044"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="25">
        <location>
            <begin position="1162"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="362"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="457"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="604"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1218"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="472"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="20">
        <location>
            <begin position="691"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="736"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="748"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="20">
        <location>
            <begin position="848"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="923"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="20">
        <location>
            <begin position="1222"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
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        <location>
            <begin position="983"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="1021"/>
            <end position="1030"/>
        </location>
    </feature>
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            <begin position="1164"/>
            <end position="1207"/>
        </location>
    </feature>
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        <location>
            <begin position="1193"/>
            <end position="1220"/>
        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022536"/>
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            <dbReference type="ARBA" id="ARBA00022659"/>
        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022974"/>
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            <dbReference type="ARBA" id="ARBA00023157"/>
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            <dbReference type="ARBA" id="ARBA00023180"/>
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        <source>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00075743"/>
        </source>
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            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005013217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1271" mass="137479" checksum="F9CBADD2D0832B9D" modified="2022-01-19" version="1">MVHVMGDAGCWLLLGFTLLPITVLGSQDDGKVIHISRVQHQAVRVGLGEPVALPCLFLLHPSASLGPNEPPDPPRVKWSKVRSASGQREDVPILVAKDNVVKVVKAYEGRVSLPGYARDRYNGTLLLRAARASDAGLYRCEVVAGIDDEQDLLPLEVMGVVFHYRPAGSRYALTFPAARRACMDNSAIIASPQHLQAAFEDGYDNCDAGWLADQSVRYPITLSRPGCYGDRNSLPGVRSYGQREPDELYDVYCYAQELQGKVFYATAPGRFTLAGARRHCQSRGAALATTGQLYLAWREGLDQCDPGWLADGSVRYPILTPRRKCGGEAPGVRTLYRFPNRTGFPPPTSKFDAYCYKGDTVGAPDSTAEQKEPEPLGSDNVLVEREDMATSGDSPRAGVLPQLGAVGPGGAEDEQLASSVTAAWRGDIPMGSSTTSSSFPSSSVWPLEDEALNALDQQQGFPDSPEPLFTLHPQTQSPAQEVTSSPPAPPALGMVPTVAAETPSTPKQSSYAGLNGRYFQLQQQSRDPLVAQDPTVADDHTVAGDPVGTVTQAPILALEVKGAAANTVETWSITRPSAESPHRGDPYPLSNEVEEEIGHKLLAPSITPVPPSQRDLPQWSPPSAPQGPGGPTQSSLPSSPPSPVAPGDIPHHQDVSTGEAQPRGDSPQPPADVTEDFSGDAAPKEEDSPILPWPPLPPAPLVAEGPGTAAQPSSDSNGALGDGSLERQRKAVAFDLPPMGLPGSPSPTAVSSPHPQSRLSPTDPQGALEMGAQPAHEHLDVVMGPQDEAAITPVAPDVPSAPPTDSEVTPQLGSEWPLEGSGRVGDGPTAAPQHPNPSAPVLEEEEYPPQPPDPQQSPSPGEEDTSGEAKSEPPPNMATHPSAPPDTHWPSPTAPHPWVPEGPEAPSAEPLFEPTTPGGAGGALLLDADSGSGEEPVVEERELLVWADTSNSSQHAPADPCQTNPCLHGGTCHANGSISGCSCAPGFTGENCEIDIDDCLSSPCQNGGTCIDEVNAFVCLCLPSYGGSRCEKDTEGCDHNWHKFQGHCYRYFSRRRSWEDAERDCRRRSGHLTSIHSQEEHSFINSFGHENTWIGLNDRIVEQDFQWTDNTGLQYENWRENQPDNFFAGGEDCVVLVSHEIGKWNDVPCNYNLPYICKKGTVLCGPPPEVENAFLVGKKKEKYSIHSTVRYQCEEGFTQRHIPTIRCHSNGKWDRPKLLCTKPRRSHRARRHHRHRHSHPHHQHHHHKPRKERRKHHKHLRLDWMEEGHYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TJ13</accession>
    <name>A0A8C2TJ13_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized LOC107312240</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC107312240</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015714968.1">
        <property type="nucleotide sequence ID" value="XM_015859482.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TJ13"/>
    <dbReference type="Ensembl" id="ENSCJPT00005018954.1">
        <property type="protein sequence ID" value="ENSCJPP00005013149.1"/>
        <property type="gene ID" value="ENSCJPG00005011119.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107312240"/>
    <dbReference type="KEGG" id="cjo:107312240"/>
    <dbReference type="GeneTree" id="ENSGT00940000163503"/>
    <dbReference type="OrthoDB" id="9944868at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4100">
        <property type="entry name" value="Zona pellucida, ZP-C domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3210">
        <property type="entry name" value="Zona pellucida, ZP-N domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058876">
        <property type="entry name" value="Ig-like_ZP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057638">
        <property type="entry name" value="Ig_ZP2_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055355">
        <property type="entry name" value="ZP-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042235">
        <property type="entry name" value="ZP-C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055356">
        <property type="entry name" value="ZP-N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048290">
        <property type="entry name" value="ZP_chr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47130">
        <property type="entry name" value="SI:DKEY-19B23.11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47130:SF3">
        <property type="entry name" value="ZONA PELLUCIDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26562">
        <property type="entry name" value="Ig-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23736">
        <property type="entry name" value="Ig_ZP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00100">
        <property type="entry name" value="Zona_pellucida"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23344">
        <property type="entry name" value="ZP-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00023">
        <property type="entry name" value="ZPELLUCIDA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034372441" evidence="3">
        <location>
            <begin position="26"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="4">
        <location>
            <begin position="606"/>
            <end position="868"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005013149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="904" mass="101855" checksum="DB3DD522460D01F7" modified="2022-01-19" version="1">MKLGLVLRLLSIGILISATWTQVASGLVSAECLKNFLHLTLSMEHLKDKYLSFSAVDQSGVAWEFDEALASQCGYTIMYSSRNSIVFRASALSCHSHLEKDVFTVTIKIKVSHTSDMKNATTHLKSASCPYGPWSPRELVCETNYMEVSVQRVVPQTEDIVLNEPEDWVLSYPEPKAGEASIWQIVFHQPEEKRALLVSDAWKAGYGLNTTENRILLRVPYNTAQTQLVKAQGITFSVVRSSTFYKQQWMILMVDTTVACPVDGVDYTNKTIIWTVPKYFQALCAGATGFKDVLVEAGVNLHKLSAEEMASRKYVLSNDLSTITMKIPIGAEGGAYKTSVSSGKHGAKYSISLFLEHQWKDNKWGLTKYTIIKEIETPFEQAELAITNSLNLSARLMNVTVGMFLLDVELMNLTIEGATVTVSEAIQRGYLTYEIQYANGSKIYVIQVSFDAPGIKKEYITDDTREYTLNVTLKFIILPTSDTFAVPIVTVSAVKEPVLPSARGFCDEKDFHLIITRGNMHQNWLPFISDQHLMPEAAQKYYYSLNDNGTHLAVSVPFLSSLVDYKDIHTSGVLASLHLTLKDGITLANKKDFSISCRFPPSKLIQCFPNGNVVITAIKLVRLADLDTSLLVLRDKQCKPSLVTKKIATFKFNVNTCGTSRKFNSTSITYENDVLYFKPGNNIPVYQLKFVCVYTIKHSADIRYENKKNLPLSIKPGFGSLNLSLKLFKEKSYSEPYQELEYPVVKYLREALYFEVELLQPADPRLELNLKDCWATNSQNQDSLPQWPILVNGCENSEDFYRTVFHEVNYSHRVKFPQHLKRFEVTVFTFVQDTTLLQMQLYFHCSVVICSTTPLPSDVICQRRCNPGTHRLDRSAEPHPWGQVSSGAVLIRKENVASKGEHAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TJL0</accession>
    <name>A0A8C2TJL0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">TIR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Toll-like receptor family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TJL0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005021120.1">
        <property type="protein sequence ID" value="ENSCJPP00005014891.1"/>
        <property type="gene ID" value="ENSCJPG00005012377.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163576"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002224">
        <property type="term" value="P:toll-like receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10140:FF:000001">
        <property type="entry name" value="Toll-like receptor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000881">
        <property type="entry name" value="Toll-like receptor 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001090">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365">
        <property type="entry name" value="TOLL-LIKE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365:SF545">
        <property type="entry name" value="TOLL-LIKE RECEPTOR 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01582">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01537">
        <property type="entry name" value="INTRLKN1R1F"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0391">Immunity</keyword>
    <keyword evidence="13" id="KW-0395">Inflammatory response</keyword>
    <keyword evidence="3" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="763"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="15">
        <location>
            <begin position="814"/>
            <end position="931"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005014891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="931" mass="104811" checksum="EEBFC4481A189B00" modified="2022-01-19" version="1">MGSLSHPWHQPLTLPISPRPSTRMCSPHCCPPRLLLLLTGTLMPMVHSYGFRNCIEDVKVPFHFRCIQRFLESPAPAVSDLPPHATALNLSYNIMRCLQPSAFARLPQLQTLGLAYNKLETLSPGAFNGLGVLNVLDLSHNQLTTLAEGVFNSLGNLSSLLVQHNPLRTVSPSALLPLVSLRLLSLRGGRLSGLGPVAAAVQGLAQLELLDLCANNLTTLGPGPPLPASLLTLQLCNNSLGELAGGSPEMLSHVKVLDLSYNNISRAEAFTQLDLHNISLLHLMGNPLDVFHLLDISDIRPRNLDFSGLVLGAQGLNKVCLKLQGPQALQRLQLQRNGLKELRSHELESCPVLRELDLSWNRLQQVGCASRLLGKKQWEELEVLTVEHNLLKKLPSCLEAQVLPRLHNISFRFNRILTVGPSAFAYAPALRVLWLNINSLVWLDKQALWGLHNLTELRLDNNLLTDLYGTSFAHLCSLRTLNLRNNRVSVLFAGVFQGLSKLQTLDLGGNNLRHLAAQSLQGLPKLRRLYLDRNRLLEVSSTVFAPVQATLGVLDLQANNLQYISQWLRKPPPFHNLSKLYDLKLQAQQPYGLKMLPHHFFQGLVELQRLSLSRNMLRAIPPDVFEDLGKLRSLTLADSSNGIHDLPDGVFRNLGNLQFLDLENVGLHSLTLEVFGNLSKLKVLRLARNELKTFNDSVASQLPSLRYLDLRKCPLSCTCDNTWLQRWLNNSRVQVVYPYNYTCGSQHNAYIHSFDTRVCFLDLGLYLFAGTAPAVLLLLVVPVVYHRTYWKLKYHWYLLRCWVNQRWRREEKRYLYDGFVSYNSADESWVLQKLVPELERGAFRLCLHHRDFQPGRSIIDNIVDAVYNSRKTVCVVSRNYLRSEWCSLEVQLASYRLLDERRDILVLVLLEDVADAELTTGQGGVIKGSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TJQ5</accession>
    <name>A0A8C2TJQ5_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ovomucoid</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TJQ5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005019163.1">
        <property type="protein sequence ID" value="ENSCJPP00005013319.1"/>
        <property type="gene ID" value="ENSCJPG00005011237.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00520000060726"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00104">
        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.30:FF:000037">
        <property type="entry name" value="Ovomucoid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050159">
        <property type="entry name" value="Kazal-type_SerProtInhib"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001239">
        <property type="entry name" value="Prot_inh_Kazal-m"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47499:SF1">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR KAZAL-TYPE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47499">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR KAZAL-TYPE 7 SPINK7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00050">
        <property type="entry name" value="Kazal_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00290">
        <property type="entry name" value="KAZALINHBTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00282">
        <property type="entry name" value="KAZAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0722">Serine protease inhibitor</keyword>
    <feature type="domain" description="Kazal-like" evidence="9">
        <location>
            <begin position="30"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="9">
        <location>
            <begin position="74"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005013319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="130" mass="14579" checksum="C0832B728AAFEB53" modified="2022-01-19" version="1">CNLFPLLHHGGMTENKMTTCSMAMHGKCNGCSGNLACPRIFQPVCGTDNVTYPNECSLCRQILRQRLLNMFLLHYLQIDCSNFKRTDLYCTEEYVPHCGSDGVTYGNKCYFCIAVLKSHGSLSLQHLGEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TKL7</accession>
    <name>A0A8C2TKL7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chorein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TKL7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005021669.1">
        <property type="protein sequence ID" value="ENSCJPP00005015257.1"/>
        <property type="gene ID" value="ENSCJPG00005012618.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183083"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026847">
        <property type="entry name" value="VPS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026854">
        <property type="entry name" value="VPS13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166:SF125">
        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12624">
        <property type="entry name" value="VPS13_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Chorein N-terminal" evidence="3">
        <location>
            <begin position="2"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Chorein N-terminal" evidence="3">
        <location>
            <begin position="241"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="152"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="725" mass="83180" checksum="F752C048F545BCA6" modified="2022-01-19" version="1">MVLESLVADVLNRFLGDYVENLNKSQLKLGIWGGNVALDNLKIKENALVNKLTLKIPWKNLYGEAVVATLEGLYLLIVPGASIKYDAEKEEKYLQDNKQKELARIEEALQKAAEKGTKLIMQTSSGIREFAVLWKKRRKRKKYKKHFKRPFKGRDHSKDKPKEEKKDTFLEKLATQVIKNVQVKITGIHVKYEDDVCTLNVLFLMGSVECYCFSFSLQLLCLDSLSAYWNVHSKMYYHGSHEQILVIPISASARVFINPIAEVELKTPKLDCNVEVQRIAIELTKPQYLSMIDLLESIDYMVRNAPYRKYRPNVCLHKNARQWWKYAGDSVLEVHIRRCTRMWSWSNMKQHRQLLKTYKNAYKNKLTQSKLSEETHRQIQDLEKKLDVFNIVLARQQAQAETIRSGQKLLKKKGTEVEKKSGGWFSGFWGRKESKKKEDEESSVPETIDELMTPEEKAKLFTAIGYSDTSYQLSLPKQYIAHIVTLKLVSTSLTIKEDENVAETLKVQIIDLSTKISQRPGAQALKVEAKLENWYVTGLRQENIVPSLVASIGDSESSLLKIEFNINPEDSTADQSLSIVSQPVEIKYDARTINAMVEFFQTSKGMDLERLTSATLMKLEEIKERTATGLVHIIEMRKVLDLKIHLKPSYLLVPQTGFYHENSNLLILDFGTFQLNSINQGSSEASSFSSLEEIMDKAYDKFDVEIKNVQLLFGRAVKPVYSEDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TKM7</accession>
    <name>A0A8C2TKM7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Serine/threonine-protein kinase Sgk3</fullName>
            <ecNumber evidence="5">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Serum/glucocorticoid-regulated kinase 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="primary">SGK3</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="16">Interacts with GSK3B and FLII. Interacts with PDPK1 in a phosphorylation-dependent manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasmic vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Early endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Recycling endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2TKM7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005019872.1">
        <property type="protein sequence ID" value="ENSCJPP00005013872.1"/>
        <property type="gene ID" value="ENSCJPG00005011668.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005019873.1">
        <property type="protein sequence ID" value="ENSCJPP00005013873.1"/>
        <property type="gene ID" value="ENSCJPG00005011668.1"/>
    </dbReference>
    <dbReference type="KEGG" id="cjo:107310235"/>
    <dbReference type="GeneTree" id="ENSGT00940000153776"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001240">
        <property type="term" value="P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd06870">
        <property type="entry name" value="PX_CISK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05604">
        <property type="entry name" value="STKc_SGK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000065">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000018">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000030">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037900">
        <property type="entry name" value="CISK_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037709">
        <property type="entry name" value="SGK3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 19 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="10" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 19 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 20" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PX" evidence="23">
        <location>
            <begin position="6"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="22">
        <location>
            <begin position="156"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="24">
        <location>
            <begin position="414"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="111"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="132"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00063042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00074735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00077830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005013872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="490" mass="56304" checksum="2F738765F9851096" modified="2022-01-19" version="1">MDLKESCPSVSIPSSDEHREKKKRFTVYKVLVSVGRNEWFVFRRYAEFDKLYNTLKKQFPTMNLKIPAKRIFGDNFDPDFIKQRRAGLNEFIQNLVRQPELCNHPDVRSFLQMDNPKHQSDPSEDEDERSNQKLNSTSPNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAKRKLDGKYYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSINIVYRDLKPENILLDSLGHVVLTDFGLCKEGIASSDTTATFCGTPEYLAPEVIKKQPYDNTVDWWCLGAVLYEMLYGLPPFYCRDVAEMYENILHKPLVLRPGISLTAWSILEELLEKDRQSRLGAREDFLEIQKHPFFESLSWTDLLQKKIPPPFNPNVVGPDDIGNFDAVFTEEMVPYSVCISSDYSIVNASVLEADDAFVGFSYAPPSEDMFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TLE6</accession>
    <name>A0A8C2TLE6_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="28">Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6</fullName>
            <ecNumber evidence="26">2.3.2.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="31">BIR repeat-containing ubiquitin-conjugating enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="30">Baculoviral IAP repeat-containing protein 6</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="29">Ubiquitin-conjugating BIR domain enzyme apollon</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="34" type="primary">BIRC6</name>
    </gene>
    <organism evidence="34 35">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="34" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="34" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="34" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.24"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytoskeleton</location>
            <location evidence="4">Microtubule organizing center</location>
            <location evidence="4">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Spindle pole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Midbody</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="27">Belongs to the BIRC6 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.24" evidence="26"/>
    <dbReference type="Ensembl" id="ENSCJPT00005020656.1">
        <property type="protein sequence ID" value="ENSCJPP00005014529.1"/>
        <property type="gene ID" value="ENSCJPG00005011541.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156126"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004869">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008283">
        <property type="term" value="P:cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001237">
        <property type="term" value="P:negative regulation of extrinsic apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032465">
        <property type="term" value="P:regulation of cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00022">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23810">
        <property type="entry name" value="UBCc_BIRC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000014">
        <property type="entry name" value="Baculoviral IAP repeat-containing protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1170.10:FF:000001">
        <property type="entry name" value="baculoviral IAP repeat-containing protein 6 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1170.10">
        <property type="entry name" value="Inhibitor Of Apoptosis Protein (2mihbC-IAP-1), Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001370">
        <property type="entry name" value="BIR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022103">
        <property type="entry name" value="BIRC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116">
        <property type="entry name" value="(E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116:SF39">
        <property type="entry name" value="BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00653">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12356">
        <property type="entry name" value="BIRC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00238">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57924">
        <property type="entry name" value="Inhibitor of apoptosis (IAP) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50143">
        <property type="entry name" value="BIR_REPEAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="24" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="23" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="16" id="KW-0967">Endosome</keyword>
    <keyword evidence="21" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="22" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="35" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0789">Thiol protease inhibitor</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="20" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="18" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0853">WD repeat</keyword>
    <keyword evidence="19" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="UBC core" evidence="33">
        <location>
            <begin position="4497"/>
            <end position="4664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="32">
        <location>
            <begin position="455"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="32">
        <location>
            <begin position="569"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="32">
        <location>
            <begin position="1041"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="32">
        <location>
            <begin position="2869"/>
            <end position="2895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="32">
        <location>
            <begin position="3497"/>
            <end position="3518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="32">
        <location>
            <begin position="3846"/>
            <end position="3880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="32">
        <location>
            <begin position="4183"/>
            <end position="4207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="32">
        <location>
            <begin position="4739"/>
            <end position="4780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="32">
        <location>
            <begin position="462"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="32">
        <location>
            <begin position="569"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="32">
        <location>
            <begin position="592"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="32">
        <location>
            <begin position="1044"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="32">
        <location>
            <begin position="3501"/>
            <end position="3510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="32">
        <location>
            <begin position="3871"/>
            <end position="3880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="32">
        <location>
            <begin position="4188"/>
            <end position="4207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00035845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00039076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00060909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00069601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00075349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00079718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00081222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="33">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005014529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="35">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="4780" mass="522274" checksum="5543FF4D1F5B2655" modified="2022-01-19" version="1">[encoded data, 4780 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TNJ3</accession>
    <name>A0A8C2TNJ3_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">DNA topoisomerase 2</fullName>
            <ecNumber evidence="16">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC107309267</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <cofactor evidence="16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="16">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6 16">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 16">Belongs to the type II topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
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        <property type="protein sequence ID" value="ENSCJPP00005015378.1"/>
        <property type="gene ID" value="ENSCJPG00005012613.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157921"/>
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        <property type="component" value="Chromosome 2"/>
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        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="HATPase_TopII-like"/>
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        <property type="entry name" value="TOP4c"/>
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        <property type="entry name" value="TopoIIA_Trans_ScTopoIIA"/>
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        <property type="entry name" value="TOPRIM_TopoIIA"/>
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        <property type="entry name" value="DNA topoisomerase 2"/>
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        <property type="entry name" value="DNA topoisomerase 2"/>
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        <property type="entry name" value="DNA topoisomerase 2"/>
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        <property type="entry name" value="DNA topoisomerase 2"/>
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    </dbReference>
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        <property type="entry name" value="DNA topoisomerase 2"/>
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        <property type="entry name" value="DNA topoisomerase 2"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.40.50.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.199.10">
        <property type="entry name" value="Topoisomerase II, domain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Topoisomerase, domain 3"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR050634">
        <property type="entry name" value="DNA_Topoisomerase_II"/>
    </dbReference>
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        <property type="entry name" value="DTHCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013758">
        <property type="entry name" value="Topo_IIA_A/C_ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001154">
        <property type="entry name" value="TopoII_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018522">
        <property type="entry name" value="TopoIIA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031660">
        <property type="entry name" value="TOPRIM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034157">
        <property type="entry name" value="TOPRIM_TopoII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169:SF36">
        <property type="entry name" value="DNA TOPOISOMERASE 2-BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169">
        <property type="entry name" value="DNA TOPOISOMERASE/GYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08070">
        <property type="entry name" value="DTHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16898">
        <property type="entry name" value="TOPRIM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01158">
        <property type="entry name" value="TOPISMRASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00418">
        <property type="entry name" value="TPI2FAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00434">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="Type II DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52040">
        <property type="entry name" value="TOPO_IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00177">
        <property type="entry name" value="TOPOISOMERASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 15 16" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13 16" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 16" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="18">
        <location>
            <begin position="485"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="Topo IIA-type catalytic" evidence="19">
        <location>
            <begin position="740"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1114"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1306"/>
            <end position="1454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1481"/>
            <end position="1547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1129"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1308"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1338"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1362"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="1378"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="1411"/>
            <end position="1427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS52040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1592" mass="180160" checksum="462D85B2C9C32126" modified="2022-01-19" version="1">MLLKKSCESRCCGYSSRTCNPGGGLWGPLGSTLFDNQINASKKEESESVNKNDTSKKLSVERVYQKKTQLEHILLRPDTYIGSVEPLTQLMWVYDEDVGMNCREVTFVPGLYKIFDEILVNAADNKQRDKNMTCIKISIDPESNIISIWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETACKEYKHSFKQTWMNNMMKTSEPKIKHFEGDDYTCITFQPDLSKFKMEKLDKDIVSLMTRRAYDLAGSCKGVKVMLNGKKLPVNGFRSYVDLYVKDKLDETGVALKVIHEVVNERWDVCLTLSEKGFQQISFVNSIATTKGGRHVDYVVDQVVGKLIEVVKKKNKAGVSVKPFQVKNHIWVFVNCLIENPSFDSQTKENMTLQPKSFGSKCQLSEKFFKAASNCGIIESILNWVKFKAQTQLNKKCSSVKHSKIKGIPKLDDANDAGGKHSLDCTLILTEGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKSYEDRESLKSLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLKHGFLEEFITPIVKASKNKQELSFYSIPEFDEWKKHMENHKAWKIKYYKGLGTSTAKEAKEYFADMARHRILFRYAGPEDDAAITLAFIKKKIGDRKEWLTNFMEDTRQRRLHGLPEVKTKHLTYKDFINKELILFSNSDNERSIPSLVDGLKPEQRKVLFTCFKRNDKREVKVAQLAGSVAEMSAYHHGEQALMMTIVNLAQNFVGSNNVNLLQPIGQFGTRLHGGKDADSPRCISTMLSPLARLLFPPVDDNLLKFLYDDNQRVEPEWYMPIIPMVLVNGAEGIGTGWACKLPNYDTREIVNNIRRMLDGLDPHPMLPNYKNFKGSIQELGQNQYVVSGEISVVDRNTVEITELPVRTWTQVYKEQVLEPMLNGTEKTPALISDYKEYHTDTTVKFVVKMTEEKLTQAEAAGLHKVFKLQTSLTCNSMVLFDHMGCLKKYETVQDILKEFFDLRLHYYSLRKEWLAGMLGAESTKLNNQARFVLEKIQGKITIENRSKRDLIQMLVQRGYESDPVKAWKEAQEKAAEEEEPQNPNDDASSASGSTSGPDFNYILNMSLWSLTKEKVEELIKQRDSKVGRELNDLKRKSASDLWKEDLAAFVEELEKVEAQERDDILAGMIDKPIKGEVGKPKMKKLQLEETMSSPFGRRIVPQITSAMKADASRKLLKREKGDADSVAIKMEFDEEFGVQAEGGGDDAVNTAALAANIAKVKKEKEEPGTRVRRTPSSTKSSAKKVKKRNPWSDDESKSESDLEESEPVIIPRDSLLRRAAAERPKYTFDFSEEEDDADDDDDANNNNDLDELKVKASPGINDREEEFVPSDSLEKDEYDFSPVKTKPSPDDEEDSLPPFSSFFNPKPTEKILSETVAAKKGKFLHFHLYVPPKPKRAPKAKKMETVNSDSDSEFGIPKKTAAPKGKGRGATKRKASDSYNEGEYNSMKKAPKSSPSTFDQDSDVEIFLSGFASKTAPKPQTGRARKEVKYFAESGEDDDFDMFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TNP3</accession>
    <name>A0A8C2TNP3_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CCZ1 homolog, vacuolar protein trafficking and biosis associated</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">CCZ1</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCZ1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015732115.1">
        <property type="nucleotide sequence ID" value="XM_015876629.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TNP3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005023215.1">
        <property type="protein sequence ID" value="ENSCJPP00005016531.1"/>
        <property type="gene ID" value="ENSCJPG00005013568.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107320610"/>
    <dbReference type="KEGG" id="cjo:107320610"/>
    <dbReference type="CTD" id="51622"/>
    <dbReference type="GeneTree" id="ENSGT00390000004713"/>
    <dbReference type="OrthoDB" id="240546at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035658">
        <property type="term" value="C:Mon1-Ccz1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013176">
        <property type="entry name" value="Ccz1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043987">
        <property type="entry name" value="CCZ1/INTU/HSP4_longin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043989">
        <property type="entry name" value="CCZ1/INTU/HSP4_longin_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043988">
        <property type="entry name" value="CCZ1/INTU_longin_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13056">
        <property type="entry name" value="VACUOLAR FUSION PROTEIN CCZ1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13056:SF0">
        <property type="entry name" value="VACUOLAR FUSION PROTEIN CCZ1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19031">
        <property type="entry name" value="Intu_longin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19032">
        <property type="entry name" value="Intu_longin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19033">
        <property type="entry name" value="Intu_longin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCZ1/INTU/HSP4 first Longin" evidence="2">
        <location>
            <begin position="18"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="CCZ1/INTU second Longin" evidence="3">
        <location>
            <begin position="212"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="CCZ1/INTU/HPS4 third Longin" evidence="4">
        <location>
            <begin position="364"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005016531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="474" mass="54963" checksum="D22D1DECD6EA1B80" modified="2022-01-19" version="1">MAAAGGAGQEKQLAPTLLSFFIYNPKLGPKEGEEEKKILFYHPNEVEKNEKIRNVGLCEAIVQFTRTFSPTKPAKSLHTQKNRQFFHEPEENFWMVMVVRNPIIEKHKDGKPVYEYQEEELLDKVYSSVLQQCYSMYKLFNGTFLKAMEDGGVKVLKERLEKFFHRYLQTLHLQSCDLLDVFCGISFFPLDKMTYLKIQSFINRMEESLNIVKYTAFLYNDQLIWSGLEQDDMRILYKYLTTSLFPRHMEPELAGRDSPIRAEMPGNLQHYGRFLTGPLNLNDPEAKCRFPKIFVNTGDTYEELHLIVYKAMSAAVCFMIDASIPPTLEFCRKLDSIVGPQLTVLASDICEQYNINKRISGAEKEPQFKFIYFNHMNLAEKSTIHMRKTPSVSLASVHPDLMKILGDINSDFSRVDEDEEIIVKAMSDYWVVGKKSDQRELYVILNQKNANLIEVNEEVKKLCATQFNNIFFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TP45</accession>
    <name>A0A8C2TP45_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">U3 small nucleolar ribonucleoprotein protein MPP10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MPHOSPH10</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
            <location evidence="1 7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the MPP10 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015728009.1">
        <property type="nucleotide sequence ID" value="XM_015872523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TP45"/>
    <dbReference type="Ensembl" id="ENSCJPT00005021720.1">
        <property type="protein sequence ID" value="ENSCJPP00005015300.1"/>
        <property type="gene ID" value="ENSCJPG00005012696.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107318557"/>
    <dbReference type="KEGG" id="cjo:107318557"/>
    <dbReference type="CTD" id="10199"/>
    <dbReference type="GeneTree" id="ENSGT00390000011359"/>
    <dbReference type="OrthoDB" id="445326at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034457">
        <property type="term" value="C:Mpp10 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012173">
        <property type="entry name" value="Mpp10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17039">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN MPP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17039:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN MPP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04006">
        <property type="entry name" value="Mpp10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017300">
        <property type="entry name" value="snoRNP_Mpp10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 7" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="259"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="536"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="644"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="260"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="536"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="559"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="573"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="654"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR017300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="664" mass="76388" checksum="61B874219C3E82B2" modified="2022-01-19" version="1">MAAVSGLEKCLRVAGAAAARPERFLSVQDELAADFRTLTKTLYDLNKALGSSVVRGSPLKELVIENFDEEQIWQQLELQNNVILDVFQKSVAQCTNDKDLCLISDQEDDGSDAEASSDSEVEDMIEAETELEDAYIKHKTEAKEKKSKPRESVIEKYSDEDSDVDFDIEALEQETKTAKKTTVKKTGRKSVVDDKFFKLAEMEAFLEQVEKENGERDEEEEDDIDYFEDIISDDEEEEFEEAKVKPVKSSRDLTYKDFFDPVDDNDDLAADAAEDYDDEEADSAIEKENEESMSEAEDINEAVMENMRNKKVSFSLPDDSETEDVTDMQLERDIDLNDMKSSFEKRQEKMSEKIKSLEEELLEEKPWQLKGEVTGHKRPENSLLEETVLFDHAVRMAPVITEETTFKLEDIIKQRILDEAWDDVVPKEKPKEDAFEYKKRITLDHEKSKLSLAEIYEQEYLKLQQEKTEEEENPEHKEIQEMMDSLFLKLDALCNFHFTPKPPVPEVKIVSNLPAISMEEVAPVAVSDAALLAPEEIKEKNKAGDVKTDAEKTPTDKKRERRKKKLRKRIKLREKEKRQKLLEKMKPEHSTKLSKKAAAAKLKKLTKEGKASLLKDEGKDKAVKSSQAFFSQLQDQVRMQIKDANKLKKKQKKQKDISVHKLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TP59</accession>
    <name>A0A8C2TP59_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acyl-aliphatic-L-amino acid amidohydrolase</fullName>
            <ecNumber evidence="3">3.5.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">N-acyl-L-amino-acid amidohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ACY1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.14" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2TP59"/>
    <dbReference type="Ensembl" id="ENSCJPT00005020790.1">
        <property type="protein sequence ID" value="ENSCJPP00005014626.1"/>
        <property type="gene ID" value="ENSCJPG00005012194.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155631"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070062">
        <property type="term" value="C:extracellular exosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004046">
        <property type="term" value="F:aminoacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05646">
        <property type="entry name" value="M20_AcylaseI_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000019">
        <property type="entry name" value="Aminoacylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.900:FF:000001">
        <property type="entry name" value="Aminoacylase-1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.360:FF:000005">
        <property type="entry name" value="Putative Aminoacylase-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052083">
        <property type="entry name" value="Aminoacylase-1_M20A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010159">
        <property type="entry name" value="N-acyl_aa_amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01880">
        <property type="entry name" value="Ac-peptdase-euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45892">
        <property type="entry name" value="AMINOACYLASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45892:SF1">
        <property type="entry name" value="AMINOACYLASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="11">
        <location>
            <begin position="239"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="424"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR610159-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR610159-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005014626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="459" mass="50711" checksum="711734694DC939C8" modified="2022-01-19" version="1">HIAPLCNCFFCFCFVPGSRSAGRAQRLKGTGRAAPGWRHPGVLLGPRVLVSPRRPAVLLLHGQAFTSSTWQALGTLELLAAAGHRAVAIDLPGRNKVTRLLCSQVCPGRVVLVLTWPGTNPRLRSILLNSHTDVVPVFEEHWTYPPFEAIKDSQGNIYARGAQDMKCVSIQYLEAVRRLKAEGKSFARTIHLSFVPDEEVGGYKGMVMFLQRPEFKALNVGFALDEGLASPSDTYSVFYGEKSPWWIKVKCVGSPGHGSRFITNTAAEKLHKVITSFLAFRESEKQRLKSNTNLTLGDVTSLNLTMLEGGVSFNVVPSEMSVGFDIRIPPTVDLKAFEEQVAAWCREAGDGVTYEFLQKCMDQHITSTEDSDPWWKAFSGVCRDMKLPLKLEIFPAATDSRYIRAAGYPALGFSPMNRTPVLLHDHNEFLNEDVFLRGIDIYAHLLPALASVPPLPAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TPD0</accession>
    <name>A0A8C2TPD0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3</fullName>
            <ecNumber evidence="14">2.4.1.102</ecNumber>
            <ecNumber evidence="13">2.4.1.148</ecNumber>
            <ecNumber evidence="12">2.4.1.150</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">C2GnT-mucin type</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">GCNT3</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="22">Glycosyltransferase that can synthesize all known mucin beta 6 N-acetylglucosaminides. Mediates core 2 and core 4 O-glycan branching, 2 important steps in mucin-type biosynthesis. Also has I-branching enzyme activity by converting linear into branched poly-N-acetyllactosaminoglycans, leading to introduce the blood group I antigen during embryonic development.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>3-O-[N-acetyl-beta-D-glucosaminyl-(1-&gt;3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-[N-acetyl-beta-D-glucosaminyl-(1-&gt;3)-[N-acetyl-beta-D-glucosaminyl-(1-&gt;6)]-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:56188"/>
            <dbReference type="Rhea" id="RHEA-COMP:11691"/>
            <dbReference type="Rhea" id="RHEA-COMP:14412"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:87079"/>
            <dbReference type="ChEBI" id="CHEBI:139581"/>
            <dbReference type="EC" id="2.4.1.148"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>a 3-O-[N-acetyl-beta-D-glucosaminyl-(1-&gt;3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-[N-acetyl-beta-D-glucosaminyl-(1-&gt;3)-[N-acetyl-beta-D-glucosaminyl-(1-&gt;6)]-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:56192"/>
            <dbReference type="Rhea" id="RHEA-COMP:11692"/>
            <dbReference type="Rhea" id="RHEA-COMP:14413"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:87080"/>
            <dbReference type="ChEBI" id="CHEBI:139580"/>
            <dbReference type="EC" id="2.4.1.148"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>a 3-O-[beta-D-galactosyl-(1-&gt;3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-{beta-D-galactosyl-(1-&gt;3)-[N-acetyl-beta-D-glucosaminyl-(1-&gt;6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:56212"/>
            <dbReference type="Rhea" id="RHEA-COMP:13922"/>
            <dbReference type="Rhea" id="RHEA-COMP:14419"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:137949"/>
            <dbReference type="ChEBI" id="CHEBI:139605"/>
            <dbReference type="EC" id="2.4.1.102"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>a 3-O-[beta-D-galactosyl-(1-&gt;3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = a 3-O-{beta-D-galactosyl-(1-&gt;3)-[N-acetyl-beta-D-glucosaminyl-(1-&gt;6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:56216"/>
            <dbReference type="Rhea" id="RHEA-COMP:13923"/>
            <dbReference type="Rhea" id="RHEA-COMP:14420"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:137950"/>
            <dbReference type="ChEBI" id="CHEBI:139607"/>
            <dbReference type="EC" id="2.4.1.102"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a beta-D-Gal-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-GlcNAc derivative + UDP-N-acetyl-alpha-D-glucosamine = a beta-D-Gal-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;3)-[beta-D-GlcNAc-(1-&gt;6)]-beta-D-Gal-(1-&gt;4)-N-acetyl-beta-D-GlcNAc derivative + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54820"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:138371"/>
            <dbReference type="ChEBI" id="CHEBI:138372"/>
            <dbReference type="EC" id="2.4.1.150"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the glycosyltransferase 14 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.102" evidence="14"/>
    <dbReference type="EC" id="2.4.1.148" evidence="13"/>
    <dbReference type="EC" id="2.4.1.150" evidence="12"/>
    <dbReference type="RefSeq" id="XP_015727839.1">
        <property type="nucleotide sequence ID" value="XM_015872353.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TPD0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005021710.1">
        <property type="protein sequence ID" value="ENSCJPP00005015291.1"/>
        <property type="gene ID" value="ENSCJPG00005012689.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107318495"/>
    <dbReference type="KEGG" id="cjo:107318495"/>
    <dbReference type="CTD" id="9245"/>
    <dbReference type="GeneTree" id="ENSGT00940000159331"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047225">
        <property type="term" value="F:acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003829">
        <property type="term" value="F:beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008109">
        <property type="term" value="F:N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050892">
        <property type="term" value="P:intestinal absorption"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060993">
        <property type="term" value="P:kidney morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048729">
        <property type="term" value="P:tissue morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003406">
        <property type="entry name" value="Glyco_trans_14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19297:SF81">
        <property type="entry name" value="BETA-1,3-GALACTOSYL-O-GLYCOSYL-GLYCOPROTEIN BETA-1,6-N-ACETYLGLUCOSAMINYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19297">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 14 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02485">
        <property type="entry name" value="Branch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="23" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034025621" description="Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3" evidence="23">
        <location>
            <begin position="32"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00039292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00041719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00049911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00055416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="429" mass="48830" checksum="C9738E83075416AC" modified="2022-01-19" version="1">MRLCDRKPPAVRRRCAAVLGSLLLAAAVLLSGNSRTCRDGHPRCRSRLYGALRLEPRWKIDCAGVVRGDEEAVRAALLSNLEVRNKREPLTPEEYLNMTKDCGSFKESRRYIEFPLSEEEADFPIAYSMVIHHKIEMFERLLRSLYAPQNVYCVHVDGKAPAAFQRAVRAIAACFPNVFVASRLESVVYASWSRLQADLNCMRDLLQSPVPWRYVLNTCGTDFPIKTNAETVRALRVLQGQNSMESEKPTAYKQERWKYRHRVERFIYRTATEKPPPPLRSPMFTGSAYIAATRGFVRHVLEDPEAQRFLEWAKDTYSPDEHVWATLNRAPGVPGAVPHNDKFHMSDMNALPRLVKWQYLSGDTSRGAPYPPCTGRFQRGVCIYGAGDVAWMLEQHHLLANKFDSEVDDAAIQCLESHLRHKALLGRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TPI0</accession>
    <name>A0A8C2TPI0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ciliogenesis-associated TTC17-interacting protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">CATIP</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Plays a role in primary ciliogenesis by modulating actin polymerization.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the CATIP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TPI0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005022400.1">
        <property type="protein sequence ID" value="ENSCJPP00005015849.1"/>
        <property type="gene ID" value="ENSCJPG00005013090.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154101"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044782">
        <property type="term" value="P:cilium organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.890.10">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048777">
        <property type="entry name" value="CATIP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15505:SF3">
        <property type="entry name" value="CILIOGENESIS-ASSOCIATED TTC17-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15505">
        <property type="entry name" value="RIIA DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21772">
        <property type="entry name" value="CATIP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47391">
        <property type="entry name" value="Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ciliogenesis-associated TTC17-interacting protein N-terminal" evidence="13">
        <location>
            <begin position="2"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF21772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="357" mass="39280" checksum="26DDECF559538314" modified="2022-01-19" version="1">MEAAKFLNSIGLEELERCLFAETLVLVDGGGQQQGHLWVTAQHELYEQEDQQVRSCLLLQAGSKGLLDGVPYSCTLTGYVSMQLETLEQEKHQRLEFGAHPMERKIHMVQQPHGMTITVTTQEGEAEPQHQVFSYDWASLGGLLGEAASLLLLRVLACRRAVPPGIIFPAIDKEGNLCTTTYRSLGVQQQPVGSTQVEVLVVERALHAAQGVPMVWHHSLLPSGHLARQVQVGCPVIAVLQEAPVLSSTGAEPQPLFPKQLLDWEEDAQLCSWFLDRKEELQASHSTYVQQHPELFALLADFLQTLLIRQPPDPILFAAEFFAPFARHKPPGPSFASSLSPSPFCSISCPSPPAEGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TQ35</accession>
    <name>A0A8C2TQ35_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PIH1 domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">PIH1D2</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PIH1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TQ35"/>
    <dbReference type="Ensembl" id="ENSCJPT00005023755.1">
        <property type="protein sequence ID" value="ENSCJPP00005016974.1"/>
        <property type="gene ID" value="ENSCJPG00005013905.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107324121"/>
    <dbReference type="KEGG" id="cjo:107324121"/>
    <dbReference type="CTD" id="120379"/>
    <dbReference type="GeneTree" id="ENSGT00510000048581"/>
    <dbReference type="OrthoDB" id="545063at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101031">
        <property type="term" value="C:protein folding chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097255">
        <property type="term" value="C:R2TP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00298">
        <property type="entry name" value="ACD_sHsps_p23-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050734">
        <property type="entry name" value="PIH1/Kintoun_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012981">
        <property type="entry name" value="PIH1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041442">
        <property type="entry name" value="PIH1D1/2/3_CS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22997">
        <property type="entry name" value="PIH1 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22997:SF6">
        <property type="entry name" value="PIH1 DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08190">
        <property type="entry name" value="PIH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18201">
        <property type="entry name" value="PIH1_CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIH1 N-terminal" evidence="3">
        <location>
            <begin position="71"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="PIH1D1/2/3 CS-like" evidence="4">
        <location>
            <begin position="240"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00040541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005016974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="322" mass="35940" checksum="5B9CE8785A4120DD" modified="2022-01-19" version="1">MSDAVSALWALLDEMAEQRPQLYRQLQREQRHHAQRYCGRPEPRLCLRALPVPAERLPASCPARGAARGPLFVNVCGWSRVPRPAEPQGRIPVIAGPMEAAGGDDSYSVIDIAYNPDVLRRREENPEAMGHLIHLTLKFIEDQCNLILSHSYEIESFKLKGSPDRMWQRLKSRQPPPPLGQDTLKELTLDQLLHSIEAEDHSAAPVLLKEGSTTQSKVQLIEEISSTEVLEELSTPAYEMSTVRDANNKPVRIELKVELPEVSSVSECDLGISKDDVIIDVPEKYKLQLDLPELVDEETTTAVFNKGKGVLFITMPVAKAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TQJ0</accession>
    <name>A0A8C2TQJ0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Acidic leucine-rich nuclear phosphoprotein 32 family member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ANP32E</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Histone chaperone that specifically mediates the genome-wide removal of histone H2A.Z/H2AZ1 from the nucleosome: removes H2A.Z/H2AZ1 from its normal sites of deposition, especially from enhancer and insulator regions. Not involved in deposition of H2A.Z/H2AZ1 in the nucleosome. May stabilize the evicted H2A.Z/H2AZ1-H2B dimer, thus shifting the equilibrium towards dissociation and the off-chromatin state. Inhibits activity of protein phosphatase 2A (PP2A). Does not inhibit protein phosphatase 1. May play a role in cerebellar development and synaptogenesis.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Multifunctional protein that is involved in the regulation of many processes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 11">Belongs to the ANP32 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TQJ0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005023765.1">
        <property type="protein sequence ID" value="ENSCJPP00005016984.1"/>
        <property type="gene ID" value="ENSCJPG00005013913.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182907"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098839">
        <property type="term" value="C:postsynaptic density membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098895">
        <property type="term" value="C:postsynaptic endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140713">
        <property type="term" value="F:histone chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019212">
        <property type="term" value="F:phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000003">
        <property type="entry name" value="Acidic leucine-rich nuclear phosphoprotein 32 family member A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045081">
        <property type="entry name" value="AN32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11375">
        <property type="entry name" value="ACIDIC LEUCINE-RICH NUCLEAR PHOSPHOPROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11375:SF5">
        <property type="entry name" value="ACIDIC LEUCINE-RICH NUCLEAR PHOSPHOPROTEIN 32 FAMILY MEMBER E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU369103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005016984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="169" mass="19122" checksum="DC9D14D7995D64B3" modified="2022-01-19" version="1">MEMKKRINLELRNQAPEEVTELVLDNCKSSNGEIEGLNDSFKELEFLSMANVQLTSLAKLPTLSKLRKLELSDNIISGGLEVLAEKCPNLTHLNLSGNKIKDLGTIEPLQNLKNLKSLDLFNCEITNLEDYRDSIFDLLQQITYLDGFDQEDNEAPDSEDDDDEGKFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TQJ4</accession>
    <name>A0A8C2TQJ4_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Nucleoporin 210 like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">NUP210L</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NUP210 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_032305057.1">
        <property type="nucleotide sequence ID" value="XM_032449166.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005024271.1">
        <property type="protein sequence ID" value="ENSCJPP00005017413.1"/>
        <property type="gene ID" value="ENSCJPG00005014216.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107324477"/>
    <dbReference type="CTD" id="91181"/>
    <dbReference type="GeneTree" id="ENSGT00390000009491"/>
    <dbReference type="OrthoDB" id="361283at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060009">
        <property type="term" value="P:Sertoli cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007286">
        <property type="term" value="P:spermatid development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1080:FF:000007">
        <property type="entry name" value="Nuclear Pore complex Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003343">
        <property type="entry name" value="Big_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058779">
        <property type="entry name" value="Ig_NUP210_13th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057586">
        <property type="entry name" value="Ig_NUP210_16th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055096">
        <property type="entry name" value="Ig_NUP210_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055097">
        <property type="entry name" value="Ig_NUP210_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055098">
        <property type="entry name" value="Ig_NUP210_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056897">
        <property type="entry name" value="Ig_NUP210_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056898">
        <property type="entry name" value="Ig_NUP210_6th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055099">
        <property type="entry name" value="Ig_NUP210_7th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056899">
        <property type="entry name" value="Ig_NUP210_9th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008964">
        <property type="entry name" value="Invasin/intimin_cell_adhesion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045197">
        <property type="entry name" value="NUP210-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055094">
        <property type="entry name" value="NUP210_Ig15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055095">
        <property type="entry name" value="NUP210_Ig_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23019:SF1">
        <property type="entry name" value="NUCLEAR PORE MEMBRANE GLYCOPROTEIN 210-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23019">
        <property type="entry name" value="NUCLEAR PORE MEMBRANE GLYCOPROTEIN GP210-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02368">
        <property type="entry name" value="Big_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26181">
        <property type="entry name" value="Ig_NUP210_13th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26183">
        <property type="entry name" value="Ig_NUP210_14th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22959">
        <property type="entry name" value="Ig_NUP210_15th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25354">
        <property type="entry name" value="Ig_NUP210_16th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22967">
        <property type="entry name" value="Ig_NUP210_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22969">
        <property type="entry name" value="Ig_NUP210_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22963">
        <property type="entry name" value="Ig_NUP210_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24991">
        <property type="entry name" value="Ig_NUP210_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26182">
        <property type="entry name" value="Ig_NUP210_5th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24935">
        <property type="entry name" value="Ig_NUP210_6th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22962">
        <property type="entry name" value="Ig_NUP210_7th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26184">
        <property type="entry name" value="Ig_NUP210_8th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24902">
        <property type="entry name" value="Ig_NUP210_9th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22957">
        <property type="entry name" value="NUP210_Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00635">
        <property type="entry name" value="BID_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49373">
        <property type="entry name" value="Invasin/intimin cell-adhesion fragments"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1827"/>
            <end position="1846"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="11">
        <location>
            <begin position="480"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="11">
        <location>
            <begin position="1101"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1872"/>
            <end position="1893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1874"/>
            <end position="1893"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005017413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1893" mass="206909" checksum="C34A0BAC96B3AACB" modified="2022-01-19" version="1">MRSQQMSGTRCPKAHAQNRDGGNIALRAAPFCFADRMRRARRFSLLAFVVFVAVPNCAFKLNVPKVLLPFSREMRVPFVLEAERGCYSWRSMHYNVAAEPLYKNGTACSQKALLSAQSTQPTKLSSAVIAEEHVTGHMLRCDVMVDVIDSIEILSRTREIYVEDSPLELAVRALDVKGNTFSSLSGMVFEWSIAKDEDLDSIELSEKIRILKYSEADYSPPNHIVELERAEKQGDRILVSGMTTGAAVVKVRIHESTYKKVAAAAIRLLVLENIVLIPAHDVHLLVGAFIKYRVAKVVQGKITELEFPLEHYELELRDHVAAPGASELPVAKLEGKAATVRAVQLGQSSLVVVHRNVHMRAASGLPNCTIHVVEAGFLDFSVYPGDRWVLEAQREYTITVEVYDSDSTKVYLSDNLRITHHLPKEYFEVLTSSLNGSYYVVRVLKAGSTGIRAELVSVLQQDGSGAPLPTAISREQEVKIFHPITLSKSFLAFPWHPTAVLYQYRVQVKGGSGNFSWISSNQTVATVTIKGAVSAGLAQGNCTVQARDAQNPFHYAEIQVFVEPLAELKLMPLRADVEVGHAVVAPLQAYFTHRETRQHTAFTDCSLLPLDISMEKRGVFVLPEGGRMGNQKPDLTFCSSFQIEARSVGHTSLTVRVNVHQQYLETNATFAAYEPLKAVNLVEMALVTWKAAKEIVFEGGPGPWVLEPSHFFSELKMEHEDKIKYVQIHLPTQRKVTQYVYQVVCLELGEQVLTFHVGNRASQQNPAPAVETAMVTFICAVPASMTVSPAYGALRAVPPCLLPQHSKQLIPISSRRSTVLELAMFDGQQRKFDNFSSLVLQWKSSNRSLAHFSDARATRMVLKDDGSGQTRLHGQQLLEVHQIKGTVRVEVSFVKYRTGGGPQAASGLFTSVEFLLVDDVMVLPDNVTVYNHPAVKEQFSLVEGSGYFLVNSSKEGIVNVRYLEADGAIEVTPLQPGFLSLAVRDSCLASLAPVAAQVHVSDVQEVEVDLNEKVEIGSSITATVRVLGSQRLPLRSKYFKYMKLQLQAASPIVTLVQVEEVGEYSQLHTLHAVAVGQTTLVATAWDKMGRKITSAPRKIEVFPPFKLIPRKITLIPHNVMQVMSEGGPQPQSIVHFFVTNRSVAEVSSLGHVTAKAVGATTIQGTVQVVNEDTGRVTVFLQDQVELEVIPLKAVRIHVPSTRLIAGTEMPVFVVGLNNMLTPFSFSNANPELSFQWSVSKRDVLELLPRHTKVSIQLPAQNNVAMVVYTRAAGRTSIRVKVQCLNASAGQFEGNVAELSDEVQVLVFEKLFVFSPLFSTEQILMTTNSQLKLYTNREGAASVSFQILQCYPNSSVLEERDQGLLRAGPISGIAALEVTSVEQFGVNQTIITSIQIAPISYLRINVSPQIYTSSGISLAAFPLGMSLLITVEFYNSIGEKFHAQHAQLHLSVNRDDLLLIRPANKNHTYVAQAVSRGVTLLTVQDRKHPGVVDYIPVPVDCAIQPELPRALAVGDVVCFSSPLVNQEGDPGTWHVSPPTMLSIDSVSGAALAKSSGTATVFHEIPGIVKTYREVAVNGSSQLHLQTGQKSFLTNAPNSSAFHVLITTSSGTETLQGSCSSAQLSAITQRLVPQSLLQCNLKFSSTVVDVAAGDVFLVSPEFSTQEGLYVCVITVKPQPSSALLALSTANTSVRLVASLSSDTHSVLIPFLPAFYLPQSELAFSSTQLTDVLSVMGAEKVLENLEVQSISPAVEVLPSEFSSKPGFVHYTVRALNLSSLQQKPAASIIISCALTGQRDVVTAQAVMVEHPPGQHGALGLHWQLAGSYQILLFTLFAVLGSTAVTYLAYNAFVSRLQSLPLVYVSNLVTPQPGYTHPPSSIQGGSRTQMGLWSVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TRI0</accession>
    <name>A0A8C2TRI0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Eukaryotic translation initiation factor 4E type 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Eukaryotic translation initiation factor 4E-like 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">eIF4E-like protein 4E-LP</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">EIF4E2</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation. In association with GIGYF2, assists ribosome-associated quality control (RQC) by sequestering the mRNA cap, blocking ribosome initiation and decreasing the translational load on problematic messages. Part of a pathway that works in parallel to RQC-mediated degradation of the stalled nascent polypeptide. GIGYF2 and EIF4E2 work downstream and independently of ZNF598, which seems to work as a scaffold that can recruit them to faulty mRNA even if alternative recruitment mechanisms may exist.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation. Acts as a repressor of translation initiation. In contrast to EIF4E, it is unable to bind eIF4G (EIF4G1, EIF4G2 or EIF4G3), suggesting that it acts by competing with EIF4E and block assembly of eIF4F at the cap. In P-bodies, component of a complex that promotes miRNA-mediated translational repression. Involved in virus-induced host response by mediating miRNA MIR34A-induced translational silencing which controls IFNB1 production by a negative feedback mechanism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Interacts with EIF4EBP1, EIF4EBP2 and EIF4EBP3. Does not interact with eIF4G (EIF4G1, EIF4G2 or EIF4G3). Component of the 4EHP-GYF2 complex, at least composed of EIF4E2, GIGYF2 and ZNF598. Interacts with GIGYF2 (via the 4EHP-binding motif); the interaction is direct. Interacts with EIF4ENIF1/4E-T (via YXXXXLphi motif); increasing affinity for the 7-methylguanosine-containing mRNA cap.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 19">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TRI0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005023457.1">
        <property type="protein sequence ID" value="ENSCJPP00005016739.1"/>
        <property type="gene ID" value="ENSCJPG00005013729.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154694"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098808">
        <property type="term" value="F:mRNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035278">
        <property type="term" value="P:miRNA-mediated gene silencing by inhibition of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045947">
        <property type="term" value="P:negative regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060339">
        <property type="term" value="P:negative regulation of type I interferon-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060337">
        <property type="term" value="P:type I interferon-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.760.10:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 4E type 2 isoformX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019770">
        <property type="entry name" value="TIF_eIF_4E_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF17">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E TYPE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00813">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 19" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10 19" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 19" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="12" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="8" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00054290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00054780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00062477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00070561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00077912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00083266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005016739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="247" mass="28469" checksum="5A71F0A99A8325E5" modified="2022-01-19" version="1">MNNKFDALKDDDSGDHDQNEENNTQKDSEKEKNDREKPQSTTKRKAVVPGPAEHPLQYNYTFWYSRRTPGRPTSSQSYEQNIKQIGTFASVEQFWRFYSHMVRPGDLTGHSDFHLFKEGIKPMWEDDANKNGGKWIIRLRKGLASRCWENLILAMLGEQFMVGEEICGAVVSVRFQEDIISIWNKTASDQATTARIRDTLRRVLNLPPNTIMEYKTHTDSINLPGPGDRGSLTRLEDHGTQRGQLYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TS61</accession>
    <name>A0A8C2TS61_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mucin-4</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TS61"/>
    <dbReference type="Ensembl" id="ENSCJPT00005023285.1">
        <property type="protein sequence ID" value="ENSCJPP00005016577.1"/>
        <property type="gene ID" value="ENSCJPG00005013611.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00730000110943"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005176">
        <property type="term" value="F:ErbB-2 class receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005533">
        <property type="entry name" value="AMOP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056619">
        <property type="entry name" value="C8-3_MUC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051495">
        <property type="entry name" value="Epithelial_Barrier/Signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003886">
        <property type="entry name" value="NIDO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13802">
        <property type="entry name" value="MUCIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13802:SF52">
        <property type="entry name" value="MUCIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23263">
        <property type="entry name" value="C8-3_MUC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06119">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00723">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00539">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00216">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50856">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51220">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1206"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="domain" description="NIDO" evidence="11">
        <location>
            <begin position="321"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="AMOP" evidence="10">
        <location>
            <begin position="479"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="12">
        <location>
            <begin position="590"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="1006"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="1165"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="118"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="1015"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="1034"/>
            <end position="1043"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005016577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1246" mass="133379" checksum="40A64609125BECD4" modified="2022-01-19" version="1">MLTGGVPAPSGGLFIGRTLIPANSLCWGQKHFSATSTATDGDGLVADHSAVTERGHWETARHSLLSDVQHRTRDINAHSFTSDPAEPFTAAVHLSQEVTPGLDEATSPFVTAASIRVGDTEPPSTTSDHVTSPAVPATTGSPHHDGIQKPGTVIPPGTASEAVTPSPATVDASEPTVPGLPAPGTAEDGLHRDTAITHPHVTSQLHTSTVPAPGMPTTAMDVTTASHVLTAPFPALAPAVSLYPFGAAEGDTECVQRTVDFNSPLLRPEIGFPLGKALRDTLYFTDNGQIIFPPTDSHVPSNPHPPSQGFSGHEALPMVAAFWDDADFSRGVGTTWYQEYPTLGSIQDPVVHDVETKIQKYLQVPYSAKWTLKVTWEKAPAYPSHLDDTQVMKGTNTYQAVLSTDGSRSFALLLYQDGGMRWDYAGLAARDVLIGFSSGDGYAQNSELTKEPPAVRYRPDQHHSSNVRGLWLFRLDSHSQVNYRLQCLAWLQAQPPPSTWSMELPPCPCSRPQAELDPRYRRSRSADRMGAGVRCVYHGTGFLEGWLERFWNGELEAFEWCCQHVGKPHFCTMYSEKRPRVGCEGYVPPTNGNAFGDPHITTLDGLTYTFNALGDFVLLLASDAHTSFVLQGRMARTGTAQATNFMAFVAQYTTTTPTTVSRAALCTPFDPRLKWAPSVSSFTDMDAEVYYSPGVLLVNTSSITAVFDGTISISISASSGMLSAVCSLLEQYHNGTRGLLGVWNHNPADDLQMPNGTNIPVNSSEEDIFNYGMTCKSELGNQPGTFNPIFLSELLQENQSHYQLAASQCHGCRECIYDMLSTGDVALGLATQSLVEDFQKRKAALSKWGGVWGTGKITRQYRAAGLGRDHCHIPPLPPLPAEDGMLTWEPRGTAPLSITLQAVSPHLPPALLQLSFTLCSCRSIQQCDYSSTTTIASSSLQVLAACMCDDGYWGSFCQHAPDPCAQGCFPGVGCDPHTGCGPCPPGLTGDGLHCAGDGLGCGTACRSHSCPVGFCSNGGRCRLHPPSCTPTCECPPAFTDQHCVVAGGDFQPLASTGGTASRFSPIRTADGLTFAVVAEFTYNSSSFVIWFLNEELTAAITTAFNGQRARGPGDAPSGVAAPIPCAWTNPSAVSVPELRHYFSCTLYGYEGYQLDYVGNVGLICISPCKKGYCQHGGHCQHLPEGPTCSCVPFSIFSPGGARCEQLAVSLAAFISILVGALALLCLLLSIACLAAHLCRRRQELQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TUM6</accession>
    <name>A0A8C2TUM6_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitochondrial inner membrane protease subunit</fullName>
            <ecNumber evidence="10">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">IMMP1L</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Heterodimer of 2 subunits, IMMPL1 and IMMPL2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase S26 family. IMP1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="10"/>
    <dbReference type="RefSeq" id="XP_015718977.1">
        <property type="nucleotide sequence ID" value="XM_015863491.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032301101.1">
        <property type="nucleotide sequence ID" value="XM_032445210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TUM6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005026243.1">
        <property type="protein sequence ID" value="ENSCJPP00005018932.1"/>
        <property type="gene ID" value="ENSCJPG00005015384.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107314347"/>
    <dbReference type="KEGG" id="cjo:107314347"/>
    <dbReference type="CTD" id="196294"/>
    <dbReference type="GeneTree" id="ENSGT00550000075025"/>
    <dbReference type="OrthoDB" id="308440at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042720">
        <property type="term" value="C:mitochondrial inner membrane peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.109.10:FF:000010">
        <property type="entry name" value="Mitochondrial inner membrane protease subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052064">
        <property type="entry name" value="Mito_IMP1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12383:SF16">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12383">
        <property type="entry name" value="PROTEASE FAMILY S26 MITOCHONDRIAL INNER MEMBRANE PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="3 10" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S26" evidence="11">
        <location>
            <begin position="16"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S26" evidence="11">
        <location>
            <begin position="104"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005018932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="166" mass="18686" checksum="F46B813FE5C53F02" modified="2022-01-19" version="1">MFRNALRKTLRFLGYTVQYGCIAHCAFEYLGGIVVCSGPSMEPTIQNSDIVFSENLSRHLYSIRKGDIVIVKNPTDPKSNICKRVIGLEGDKVCASNPSDFLKTHSFVPKGHVWLEGDNLRNSTDSRCYGPVPYGLIRGRICFKIWPLNDFGFLRASPNGHRFLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TW81</accession>
    <name>A0A8C2TW81_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cystinosin, lysosomal cystine transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">CTNS</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-cystine(out) + H(+)(out) = L-cystine(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:66172"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:35491"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:66173"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cystinosin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TW81"/>
    <dbReference type="Ensembl" id="ENSCJPT00005027136.1">
        <property type="protein sequence ID" value="ENSCJPP00005019616.1"/>
        <property type="gene ID" value="ENSCJPG00005015872.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000005338"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042470">
        <property type="term" value="C:melanosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015184">
        <property type="term" value="F:L-cystine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015295">
        <property type="term" value="F:solute:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007628">
        <property type="term" value="P:adult walking behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007625">
        <property type="term" value="P:grooming behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002088">
        <property type="term" value="P:lens development in camera-type eye"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007616">
        <property type="term" value="P:long-term memory"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048021">
        <property type="term" value="P:regulation of melanin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008542">
        <property type="term" value="P:visual learning"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000016">
        <property type="entry name" value="Cystinosin homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000022">
        <property type="entry name" value="Cystinosin homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005282">
        <property type="entry name" value="LC_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00951">
        <property type="entry name" value="2A43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13131">
        <property type="entry name" value="CYSTINOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13131:SF5">
        <property type="entry name" value="CYSTINOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0458">Lysosome</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0769">Symport</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="159"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="302"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005019616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="366" mass="41601" checksum="470C1BE9C13C6B85" modified="2022-01-19" version="1">FTYSNITLQIVMDKFLFPPSGGVTVLSVPEVVLLENGSSTNVTISLRAPLNETLMITLNITHSSKHSTIVELPDEVQLPAGHTKADFQAKADDVGQVTVYLYTNNSNLTGPRIQFQVIHSIIVKYADEVIGWIYFLAWSISFYPQLFENWRRKSVVGLSLDYIALNLTGFIAYSVFNVGLFWIPLIKEEFLHSYPSGLNPVAINDVFFSLHAVALTLLTIIQCCIYERAGQKVSKTVVGLLALAWIFTFTTLFLAAAEEMTWLQFLFCFSYIKLAVTLIKYFPQAYMNFRRKSTEGWSIGNVLLDFIGGSFSLLQMFLQSYNNDEWKLIFGDPTKFGLGVFSIIFDIVFMVQHYCLYRRRGYEPCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TWP2</accession>
    <name>A0A8C2TWP2_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">KIAA0513</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">KIAA0513</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015729701.1">
        <property type="nucleotide sequence ID" value="XM_015874215.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015729702.1">
        <property type="nucleotide sequence ID" value="XM_015874216.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032302995.1">
        <property type="nucleotide sequence ID" value="XM_032447104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TWP2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005025220.1">
        <property type="protein sequence ID" value="ENSCJPP00005018123.1"/>
        <property type="gene ID" value="ENSCJPG00005014752.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107319434"/>
    <dbReference type="KEGG" id="cjo:107319434"/>
    <dbReference type="CTD" id="9764"/>
    <dbReference type="GeneTree" id="ENSGT00390000009535"/>
    <dbReference type="OrthoDB" id="6268344at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039872">
        <property type="entry name" value="KIAA0513"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13663">
        <property type="entry name" value="SIMILAR TO RIKEN CDNA 6430548M08"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13663:SF2">
        <property type="entry name" value="SIMILAR TO RIKEN CDNA 6430548M08"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005018123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="410" mass="46560" checksum="F2EBE36224B55F76" modified="2022-01-19" version="1">MEAPPDVPVGNLIDFSTEAPTHAPSEPSPPAEPSDNGHLEEVTAEESDATESADSENDMGESPAHWGHRRSSSAESFSSNHSTGSARDEAAAERRDFVRHYVEKIFTGGEDLEQEEKARFGELCSGEDGKGREWFARYVSAQRCNSKCVSEQTFYRLMQSFALVLFECHQMDDFSPAKNLMTMCFTYYYIGKTHALPLEAKEKPTGSIDSYLKSANSWLAEKKDIAERLLKNTSAKTENVKGFFGGLETKLKGPAAKKSDEGEDKAKEKLKKTVSMQSPEEEKKGEKIYLYMHLKQQPIWHNLRFWNAAFFDAVHCERRKRSPTTRGNVGEEEEKREKWCHMTQEERDDSLRFNENITFGQLGTFIHNMLAFGLTKKLCSDFLKKQATIGNLDEEQYKLLSDHIEQMATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TXB7</accession>
    <name>A0A8C2TXB7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lysozyme C</fullName>
            <ecNumber evidence="5">3.2.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LYZ</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.17"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the glycosyl hydrolase 22 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.17" evidence="5"/>
    <dbReference type="RefSeq" id="XP_015711651.1">
        <property type="nucleotide sequence ID" value="XM_015856165.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TXB7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005027266.1">
        <property type="protein sequence ID" value="ENSCJPP00005019721.1"/>
        <property type="gene ID" value="ENSCJPG00005015957.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107310471"/>
    <dbReference type="KEGG" id="cjo:107310471"/>
    <dbReference type="CTD" id="4069"/>
    <dbReference type="GeneTree" id="ENSGT00940000153832"/>
    <dbReference type="OrthoDB" id="17373at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050829">
        <property type="term" value="P:defense response to Gram-negative bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050830">
        <property type="term" value="P:defense response to Gram-positive bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031640">
        <property type="term" value="P:killing of cells of another organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16897">
        <property type="entry name" value="LYZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.530.10:FF:000001">
        <property type="entry name" value="Lysozyme C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001916">
        <property type="entry name" value="Glyco_hydro_22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019799">
        <property type="entry name" value="Glyco_hydro_22_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000974">
        <property type="entry name" value="Glyco_hydro_22_lys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11407">
        <property type="entry name" value="LYSOZYME C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11407:SF28">
        <property type="entry name" value="LYSOZYME C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00062">
        <property type="entry name" value="Lys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00137">
        <property type="entry name" value="LYSOZYME"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00135">
        <property type="entry name" value="LYZLACT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00263">
        <property type="entry name" value="LYZ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="Lysozyme-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00128">
        <property type="entry name" value="GLYCOSYL_HYDROL_F22_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51348">
        <property type="entry name" value="GLYCOSYL_HYDROL_F22_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="9" id="KW-0081">Bacteriolytic enzyme</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034129624" description="Lysozyme C" evidence="14">
        <location>
            <begin position="23"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolases family 22 (GH22)" evidence="15">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005019721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="147" mass="16278" checksum="2ABD99C673A411EF" modified="2022-01-19" version="1">MRSLLVLVLCFLPLAALGKVYGRCELAAAMKRHGLDKYKGYSLGNWVCAAKFESNFNTQATNRNTDGSTDYGILQINSRWWCNDGRTPGSRNLCNIPCSALLSSDITASVNCAKKIVSDVHGMNAWVAWRNRCKGTDVNAWIRGCRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TYL5</accession>
    <name>A0A8C2TYL5_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Protein O-glucosyltransferase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">POGLUT2</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[EGF-like domain protein] + UDP-alpha-D-glucose = 3-O-(beta-D-glucosyl)-L-seryl-[EGF-like domain protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:58116"/>
            <dbReference type="Rhea" id="RHEA-COMP:14610"/>
            <dbReference type="Rhea" id="RHEA-COMP:16010"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:140576"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose = 3-O-(beta-D-xylosyl)-L-seryl-[EGF-like domain protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:62016"/>
            <dbReference type="Rhea" id="RHEA-COMP:16010"/>
            <dbReference type="Rhea" id="RHEA-COMP:16011"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57632"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132085"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KDELC family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015706965.1">
        <property type="nucleotide sequence ID" value="XM_015851479.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TYL5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005027340.1">
        <property type="protein sequence ID" value="ENSCJPP00005019764.1"/>
        <property type="gene ID" value="ENSCJPG00005015996.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107307965"/>
    <dbReference type="KEGG" id="cjo:107307965"/>
    <dbReference type="CTD" id="79070"/>
    <dbReference type="GeneTree" id="ENSGT00940000158318"/>
    <dbReference type="OrthoDB" id="541052at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035251">
        <property type="term" value="F:UDP-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035252">
        <property type="term" value="F:UDP-xylosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000419">
        <property type="entry name" value="KDEL (Lys-Asp-Glu-Leu) containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001298">
        <property type="entry name" value="Filamin/ABP280_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF21">
        <property type="entry name" value="PROTEIN O-GLUCOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00630">
        <property type="entry name" value="Filamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00557">
        <property type="entry name" value="IG_FLMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50194">
        <property type="entry name" value="FILAMIN_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034830609" evidence="11">
        <location>
            <begin position="21"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="10">
        <location>
            <begin position="21"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="12">
        <location>
            <begin position="223"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005019764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="498" mass="57732" checksum="4CE22C9B61607844" modified="2022-01-19" version="1">MCSIWCVALGVLALGAAVSGEGRLSAEHSAVWGPGLRAEAVLPARYFYLQAVDTEGQRFTSSPGENAFQVKITAPDEQFTRVGVQVLDRKDGSFIVRYRMYASYKSLKIEVKTKDKHVAKSPYILKGPVYHENCDCPQEESSVWLEEMNCPQVFPQIQRDLANFPVVDPDKIAIEIPQRFGQRQSLCHYTIKDNEVYIKTYGEHVGFRIFMDAILLSLTRKVKMPDVEFFVNLGDWPLEKKKPPQNLHPIFSWCGSSESKDIVMPTYDLTDSVLETMGRVSLDMMSVQANTGPSWEDKNTTAFWRGRDSRKERLELVKLSRKYPEIIDAAFTNFFFFKHDENLYGPIVKHISFFDFFKYKYQINIDGTVAAYRLPYLLAGNSVVLKQDSIYYEHFYNELQPWKHYIPFKSDLSDLLEKLQWAKEHDEEAKKIAKSGQEFARNNLMGDHIFCYYFKLFQEYSRLQVSEPKIRDGMEKVQQPDDDLFPCTCHRKKTKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TZA1</accession>
    <name>A0A8C2TZA1_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">PTPRF interacting protein alpha 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">PPFIA1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the liprin family. Liprin-alpha subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TZA1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005028775.1">
        <property type="protein sequence ID" value="ENSCJPP00005020914.1"/>
        <property type="gene ID" value="ENSCJPG00005016091.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01050000244900"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048786">
        <property type="term" value="C:presynaptic active zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043622">
        <property type="term" value="P:cortical microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903077">
        <property type="term" value="P:negative regulation of protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051497">
        <property type="term" value="P:negative regulation of stress fiber assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09562">
        <property type="entry name" value="SAM_liprin-alpha1_2_3_4_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09565">
        <property type="entry name" value="SAM_liprin-alpha1_2_3_4_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09568">
        <property type="entry name" value="SAM_liprin-alpha1_2_3_4_repeat3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000003">
        <property type="entry name" value="liprin-alpha-2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000002">
        <property type="entry name" value="PTPRF interacting protein alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000004">
        <property type="entry name" value="PTPRF interacting protein alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057892">
        <property type="entry name" value="LIP-1_CC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037620">
        <property type="entry name" value="LIP-1_SAM_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037621">
        <property type="entry name" value="LIP-1_SAM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037622">
        <property type="entry name" value="LIP-1_SAM_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029515">
        <property type="entry name" value="Liprin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12587">
        <property type="entry name" value="LAR INTERACTING PROTEIN LIP -RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12587:SF15">
        <property type="entry name" value="LIPRIN-ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25526">
        <property type="entry name" value="LIP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SAM" evidence="9">
        <location>
            <begin position="908"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="9">
        <location>
            <begin position="1033"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="9">
        <location>
            <begin position="1114"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="451"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="670"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1230"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="97"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="259"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="494"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="670"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="705"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="754"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="792"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="802"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1230"/>
            <end position="1242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005020914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1265" mass="143117" checksum="00FDACDADDC4D4DB" modified="2022-01-19" version="1">MMCEVMPTISEAEIPSGGNGGHGSGSPLQSDADSHFEQLMVSMLEERDRLLETLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQEFAALTKELNVCREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPAGVSSEVEVLKALKSLFEHHKALDEKVRERLRVALERCSLLEEELGTTHKELMILKEQNNQKKTLPDGMLDINHEQENTPTTNGKRSSDGSLCHDENLAKVIELQDIIDKQNKEQTQMKERLTALSSRVAELEEDLDTARKDLIKSEEMNTKLQRDVRETMAQKEDMEERITTLEKRYLAAQREATSVHDLNDKLENEIATKDSMHRQSEDKNRQLQERLELAEQKLQQTLRKAETLPEVEAELAQRVAALTKSDLLSPGNSAAKDAKVLELTTKLRKAEERHGNIEERLRQMEAQLEEKNQELQRARQREKMNEEHNKRLSETVDKLLSESNERLQLHLKERMAALEDKNSLLREIENAKKQIEELQHEKDKLVLNIEALRAENDQVRLRATSLHHRYPMTSSSVADSHADSYGTSSVLRRPQKGRLAALRDEPSKVQTLNEQDWERAQQASVLANVAQAFESDVDVSDGEDDRETIFSSVDLLSPSGQADAQTLAMMLQEQLDAINKEIRLIQEEKENTEQRAEEIESRVGSGSLDAHGRFRSMSSIPPPYASGSLAGSSPPGSGRSTPRRIPHSPAREVDRLGIMTLPSDLRKHRRKSPASREEVRDDKATIKCETSPPSSPRSLRLDRVQKGALHTVSHEDIRDIRNSTSSQDGQTSNPSSSNSSQDSLHKAPKKKGIKSSIGRLFGKKEKGRPGQASKEALGQGGMAEADSSSQDALGLSKLGGQAEKNRKMQKKHELLEEARRQGLPFAQWDGPTVVVWLELWVGMPAWYVAACRANVKSGAIMSALSDTEIQREIGISNPLHRLKLRLAIQEIMSLTSPSAPPTSRTTTGNVWVTHEEMENLTATQQTVSLCFCFTSLKQTLAYGDMNHEWIGNEWLPSLGLPQYRSYFMECLVDARMLDHLTKKDLRGQLKMVDSFHRNSFQCGIMCLRRLNYDRKELERKREESQSEIKDVLVWSNERMIRWVSSIGLKEYANNLFESGVHGALVALDETFDYNALALLLQIPTQNTQARAVLEREFNNLLVMGTDRRLDEDDDKSFRRAPSWRKKFRPKDIRGLAAGSAETLPANFRVTTSMSSPSMQPKKMQIDGSVSGTQRLDSATVRTYSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U117</accession>
    <name>A0A8C2U117_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U117"/>
    <dbReference type="Ensembl" id="ENSCJPT00005029760.1">
        <property type="protein sequence ID" value="ENSCJPP00005021694.1"/>
        <property type="gene ID" value="ENSCJPG00005017337.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01110000267173"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055013">
        <property type="term" value="P:cardiac muscle cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003007">
        <property type="term" value="P:heart morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000022">
        <property type="entry name" value="Cardiac titin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000107">
        <property type="entry name" value="Myosin, light chain kinase a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050958">
        <property type="entry name" value="Cell_Adh-Cytoskel_Orgn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080">
        <property type="entry name" value="CONTACTIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080:SF32">
        <property type="entry name" value="MAM DOMAIN CONTAINING GLYCOSYLPHOSPHATIDYLINOSITOL ANCHOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="562"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="83"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="177"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="270"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="363"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="447"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005021694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="585" mass="64595" checksum="F64FF2E4794FF973" modified="2022-01-19" version="1">VPFGESADFECHVTGAQPIQITWSKDGREIRTGGNFNITFVANTAHLRVLRVGKGDSGQYTCQASNEAGKDFCSAQLSVKEPPKFTKKPEALRFVRLGDTVQLECKITGTAEIKITWYKNDQALQMSNRLHMSFVESTAVLTILDASAEDAGDYICEAQNSAGTASCSTSLSVKEPPVFSKVPSPVDTLKGSDVILQCEIAGTPPFEVAWFKDRRQVRSSKKFKVTAKHSIASLHILSLESQDTGEYQCKAMNEVGSDTCTCPVKFKEPPRFTKKLSDTAIFVGEATALQAVVEGSPPISVVWLKDKGEVIRESENVQMWFMDNIATLEIASAEGADVGKYICQIKNDAGMRECSAFLQVLEPAVILEKTEPITVMAGNPFTLECKVGGTPELITKWYKDGRELRNDRKYQITFFNNISTLKVFSAEKVLFSYNSSALSYLDRLVPPSFSRKLKETNGVLGSSVLLECKVSGTSPMSVAWFQDGNEIVGGEKYEISFLDNICALKLNALDVTDTGPYTCVATNVAGSDECSAFLTVQGQWKTVTDPSTKYFFPLYIIHLISWWVFFVFWFVVFFFSGFSLALSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U153</accession>
    <name>A0A8C2U153_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">small monomeric GTPase</fullName>
            <ecNumber evidence="5">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">RAB40C</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="5"/>
    <dbReference type="RefSeq" id="XP_015732879.1">
        <property type="nucleotide sequence ID" value="XM_015877393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U153"/>
    <dbReference type="Ensembl" id="ENSCJPT00005029948.1">
        <property type="protein sequence ID" value="ENSCJPP00005021849.1"/>
        <property type="gene ID" value="ENSCJPG00005017452.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107320967"/>
    <dbReference type="KEGG" id="cjo:107320967"/>
    <dbReference type="CTD" id="57799"/>
    <dbReference type="GeneTree" id="ENSGT00940000158979"/>
    <dbReference type="OrthoDB" id="6339763at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031466">
        <property type="term" value="C:Cul5-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990756">
        <property type="term" value="F:ubiquitin-like ligase-substrate adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140042">
        <property type="term" value="P:lipid droplet formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051895">
        <property type="term" value="P:negative regulation of focal adhesion assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051894">
        <property type="term" value="P:positive regulation of focal adhesion assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04121">
        <property type="entry name" value="Rab40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03742">
        <property type="entry name" value="SOCS_Rab40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000371">
        <property type="entry name" value="RAB40C, member RAS oncogene family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036036">
        <property type="entry name" value="SOCS_box-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00253">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158235">
        <property type="entry name" value="SOCS box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0564">Palmitate</keyword>
    <keyword evidence="15" id="KW-0636">Prenylation</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SOCS box" evidence="18">
        <location>
            <begin position="175"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="244"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="270"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005021849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="281" mass="31455" checksum="EE549105A5DAFB49" modified="2022-01-19" version="1">MGTQGSPVKSYDYLLKFLLVGDSDVGKGEILESLQDGASESPYAYSNGIDYKTTTILLDGRRVKLELWDTSGQGRFCTIFRSYSRGAQGILLVYDITNRWSFDGIDRWMKEIDEHAPGVPRILVGNRLHLAFKRQVPTEQARAYAEKNCMTFFEVSPLCNFNVIESFTELSRIVLMRHGMEKIWRPNRVFSLQDLCCRAIVSCTPVHLIDKLPLPVTIKSHLKSFSMANGMNAVMMHGRSYSLASSGGGSSSKGNSLKRSKSIRPPQSPPQNCSRNNCKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U2N6</accession>
    <name>A0A8C2U2N6_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phospholipase A2</fullName>
            <ecNumber evidence="8">3.1.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC107320189</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="5">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the phospholipase A2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.4" evidence="8"/>
    <dbReference type="RefSeq" id="XP_015731316.1">
        <property type="nucleotide sequence ID" value="XM_015875830.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U2N6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005029934.1">
        <property type="protein sequence ID" value="ENSCJPP00005021835.1"/>
        <property type="gene ID" value="ENSCJPG00005017437.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107320189"/>
    <dbReference type="KEGG" id="cjo:107320189"/>
    <dbReference type="GeneTree" id="ENSGT00940000157803"/>
    <dbReference type="OrthoDB" id="10069378at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047498">
        <property type="term" value="F:calcium-dependent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050482">
        <property type="term" value="P:arachidonate secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00125">
        <property type="entry name" value="PLA2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.90.10:FF:000001">
        <property type="entry name" value="Basic phospholipase A2 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.90.10">
        <property type="entry name" value="Phospholipase A2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001211">
        <property type="entry name" value="PLA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016090">
        <property type="entry name" value="PLA2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033113">
        <property type="entry name" value="PLA2_histidine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036444">
        <property type="entry name" value="PLipase_A2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11716:SF4">
        <property type="entry name" value="GROUP 10 SECRETORY PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11716">
        <property type="entry name" value="PHOSPHOLIPASE A2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00068">
        <property type="entry name" value="Phospholip_A2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00389">
        <property type="entry name" value="PHPHLIPASEA2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00085">
        <property type="entry name" value="PA2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48619">
        <property type="entry name" value="Phospholipase A2, PLA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00118">
        <property type="entry name" value="PA2_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Phospholipase A2-like central" evidence="9">
        <location>
            <begin position="71"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="95"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="97"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="112"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="118"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="119"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601211-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601211-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601211-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005021835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="200" mass="22666" checksum="B22592B6C15F79EE" modified="2022-01-19" version="1">MYMHKNPGSGELLNTPTLPFTWQYWTAEQQSTASYRYRGALPMGWRLLLLLLLHAVWKGALGKSHSLHTRGIIELAGAISCGTGRSPLAYIGYGCYCGLGGRGWPKDETDWCCHRHDCCYDKAEREGCSPKVQRYQWICEKNVVRCDNLTDKCEKMLCLCDQEAAKCWGAAPYNPQFILWPNFLCGQTHPTCHFKYGGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U4V2</accession>
    <name>A0A8C2U4V2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Wolframin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">WFS1</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Participates in the regulation of cellular Ca(2+) homeostasis, at least partly, by modulating the filling state of the endoplasmic reticulum Ca(2+) store. Negatively regulates the ER stress response and positively regulates the stability of V-ATPase subunits ATP6V1A and ATP1B1 by preventing their degradation through an unknown proteasome-independent mechanism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Interacts with ATP6V1A.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Secretory vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015718332.1">
        <property type="nucleotide sequence ID" value="XM_015862846.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U4V2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005032005.1">
        <property type="protein sequence ID" value="ENSCJPP00005023352.1"/>
        <property type="gene ID" value="ENSCJPG00005018535.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107314009"/>
    <dbReference type="KEGG" id="cjo:107314009"/>
    <dbReference type="CTD" id="7466"/>
    <dbReference type="GeneTree" id="ENSGT00390000016928"/>
    <dbReference type="OrthoDB" id="5865303at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030141">
        <property type="term" value="C:secretory granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030133">
        <property type="term" value="C:transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140597">
        <property type="term" value="F:protein carrier chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032469">
        <property type="term" value="P:endoplasmic reticulum calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006983">
        <property type="term" value="P:ER overload response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042593">
        <property type="term" value="P:glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097193">
        <property type="term" value="P:intrinsic apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001822">
        <property type="term" value="P:kidney development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903892">
        <property type="term" value="P:negative regulation of ATF6-mediated unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902236">
        <property type="term" value="P:negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043524">
        <property type="term" value="P:negative regulation of neuron apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000675">
        <property type="term" value="P:negative regulation of type B pancreatic cell apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051928">
        <property type="term" value="P:positive regulation of calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904294">
        <property type="term" value="P:positive regulation of ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045927">
        <property type="term" value="P:positive regulation of growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031398">
        <property type="term" value="P:positive regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="entry name" value="Wolfram syndrome 1 (Wolframin)"/>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
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    <sequence length="875" mass="100363" checksum="E260B85D936BA47D" modified="2022-01-19" version="1">MNSNFEPPSNPSQPQLHLGRSQLNAAAVDRSESSHKSGPPSGDAAAPSSAPGYSHSREKAEKNEAMKEEPEVLFEELLERAKAGEPKAQTEVGKHYLRLAEEEDEELNNCSAVDWFILAAKQGRREAVKLLRRCLADRRGITSENEQEVKKLSSETDLERAVRKAALVMYWKLNPKKKKQLAVSELLENVGQVDNEDGEKQPGPVPKSVQKQRRMLERLVSCESKKFIALDDFVEITKKYAKGIIPSNLIMQEEEEDDELAGKTPEELPLRLKVVKYPLHAIMEIKEYLIDVASKAGMHWLSTIIPTHHINALIFFFIISNLTIDFFAFIIPLVIFYLSFISMVICTLKVFQDSKAWENFRTLTDLLLRFEPNLDVEQAEVNFGWNHLEPYIYFLLSVFFVIFSFPIASKDCIPCSELAIVSVFFTVTSYMSLSTCAEPYTRRALMTEIAAGCLSLLQILPGNFGFLKFLGKTFFTVPVGHLFLINVSIPCLLFLYLFYLFFRMAQLRNFKGTYCYLVPYLVCFMWCELSVVILRESSGIGLVRASIGYFLFLFALPVLGVGIALMCLVHFIKWFVSLELMKIVVTLVLCAVPLLFRWWTKVNFSVVEMVKSLTRSSIVKLILVWITAVVLFCWFYVYRSEGMKVYNSTLTWNQYAFLCGPRSWKETNMARTQILCSHLEGHRVTWTGRFKYVRVTEIDNSAESAINMLPLFIGDWMRCLYGETYPLCDPKNVTMEEEELCRLKYLTKHNCHMKMFDRYKFEITVGMPFSSKNGTKLVEEDDITKDIVLKASNEFKKVLLNLRQGSIIEFSTILEGRLGSKWPVFELKAITCLNCMSKLLPAGRHVKIEHDWRSTVHKAIKFVFDFFFFPFLSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U533</accession>
    <name>A0A8C2U533_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">PRA1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ARL6IP5</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the PRA1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015730596.1">
        <property type="nucleotide sequence ID" value="XM_015875110.1"/>
    </dbReference>
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    <dbReference type="Ensembl" id="ENSCJPT00005031279.1">
        <property type="protein sequence ID" value="ENSCJPP00005022819.1"/>
        <property type="gene ID" value="ENSCJPG00005018138.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107319856"/>
    <dbReference type="KEGG" id="cjo:107319856"/>
    <dbReference type="CTD" id="10550"/>
    <dbReference type="GeneTree" id="ENSGT00390000008631"/>
    <dbReference type="OrthoDB" id="18213at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099523">
        <property type="term" value="C:presynaptic cytosol"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:glutathione metabolic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to oxidative stress"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098712">
        <property type="term" value="P:L-glutamate import across plasma membrane"/>
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        <property type="term" value="P:learning or memory"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:negative regulation of L-glutamate import across plasma membrane"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:negative regulation of mitochondrial membrane potential"/>
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    </dbReference>
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        <property type="term" value="P:positive regulation of apoptotic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of stress-activated MAPK cascade"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:protein localization to plasma membrane"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:protein transport"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004895">
        <property type="entry name" value="Prenylated_rab_accept_PRA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12859:SF2">
        <property type="entry name" value="PRA1 FAMILY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12859">
        <property type="entry name" value="PRA1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03208">
        <property type="entry name" value="PRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="97"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU363107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005022819.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="188" mass="21602" checksum="8984EBDED00B15F7" modified="2022-01-19" version="1">MEVQVAPLRSWEDFFPGSDRFARPDFKDISKWNNRVVNNLLYYQTNYLMVAAAVVAIVGFLSPLNMLIGGTVVVLVFLGFVWVSHNKDILRRMKKQYPTTFVIVIMLSSYFLISYLGDVMVFMFGITLPLLLMFIHASLRLRSIKNKLENKKEEMGLKKTPMGIILDALEQQEEGINKLADYIAKVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U5D7</accession>
    <name>A0A8C2U5D7_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Potassium voltage-gated channel subfamily Q member 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">KCNQ4</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2U5D7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005029640.1">
        <property type="protein sequence ID" value="ENSCJPP00005021594.1"/>
        <property type="gene ID" value="ENSCJPG00005017277.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159209"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042472">
        <property type="term" value="P:inner ear morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007605">
        <property type="term" value="P:sensory perception of sound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000017">
        <property type="entry name" value="potassium voltage-gated channel subfamily KQT member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000016">
        <property type="entry name" value="Putative potassium voltage-gated channel subfamily KQT member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1910">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003937">
        <property type="entry name" value="K_chnl_volt-dep_KCNQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003947">
        <property type="entry name" value="K_chnl_volt-dep_KCNQ2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013821">
        <property type="entry name" value="K_chnl_volt-dep_KCNQ_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47735">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47735:SF7">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03520">
        <property type="entry name" value="KCNQ_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01461">
        <property type="entry name" value="KCNQ2CHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01459">
        <property type="entry name" value="KCNQCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="151"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="276"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="16">
        <location>
            <begin position="77"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel voltage dependent KCNQ C-terminal" evidence="17">
        <location>
            <begin position="386"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="370"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="421"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="623"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="38"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="638"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005021594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="654" mass="73283" checksum="F370AAB877732C19" modified="2022-01-19" version="1">MAGAVRSGGGRRGAALTAVRSEDGTPPPSAPLNRRGEPTAPRPAAASRPTGTARSCRRRLQNCLYNVLERPRGWAFVYHAFIFLLVFSCLVLSVFSTIQEHQKLANQCLFILEFVMIVVFGMEYVIRVWAAGCCCRYRGWRGRLRFARKPFCVIDFIVFIASVAVIAAGTQGNIFATSALRSMRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAWYIGFLVLIFSSFLVYLAEKDTNGEFATYADSLWWGTVTLTTIGYGDKTPQTWLGRMLAAGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRTPAANLIQAAWRLYSTDTSRGYLTATWCYYDSLLPSFSTKMGIKERIRLGSPQRLGSRGRLHLGPPLHRSPSTEAVPEAPSPSKVHKSWSFNDRTRFRASLRLKPRLQPEAECPPEDSGEEKGSHCDLTFEDIMPAVKTLIRAVRILKFLVAKRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQTRVDQIVGRGGPAADKKIREKGEKSVLDAELVDELSMMGRVVKVERQVWRGQPWGCVPMYITMYITMYVPMYVPISPYVQVQSIEHKLDLLLGLYSQCLRKGSANSFSLAAVPLPREPDITSDYHSPVEHEDVSASAQTLSISRSGSANMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U5V2</accession>
    <name>A0A8C2U5V2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ankyrin repeat domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ANKRD1</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015722374.1">
        <property type="nucleotide sequence ID" value="XM_015866888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U5V2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005032774.1">
        <property type="protein sequence ID" value="ENSCJPP00005023987.1"/>
        <property type="gene ID" value="ENSCJPG00005018927.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107315936"/>
    <dbReference type="KEGG" id="cjo:107315936"/>
    <dbReference type="CTD" id="27063"/>
    <dbReference type="GeneTree" id="ENSGT00940000153956"/>
    <dbReference type="OrthoDB" id="426293at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001650">
        <property type="term" value="C:fibrillar center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031674">
        <property type="term" value="C:I band"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042826">
        <property type="term" value="F:histone deacetylase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002039">
        <property type="term" value="F:p53 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070412">
        <property type="term" value="F:R-SMAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061629">
        <property type="term" value="F:RNA polymerase II-specific DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031432">
        <property type="term" value="F:titin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055008">
        <property type="term" value="P:cardiac muscle tissue morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071347">
        <property type="term" value="P:cellular response to interleukin-1"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071222">
        <property type="term" value="P:cellular response to lipopolysaccharide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071260">
        <property type="term" value="P:cellular response to mechanical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071560">
        <property type="term" value="P:cellular response to transforming growth factor beta stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071356">
        <property type="term" value="P:cellular response to tumor necrosis factor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000279">
        <property type="term" value="P:negative regulation of DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141212">
        <property type="term" value="P:phospholipase C/protein kinase C signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043517">
        <property type="term" value="P:positive regulation of DNA damage response, signal transduction by p53 class mediator"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050714">
        <property type="term" value="P:positive regulation of protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035994">
        <property type="term" value="P:response to muscle stretch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035914">
        <property type="term" value="P:skeletal muscle cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000111">
        <property type="entry name" value="Ankyrin repeat domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126:SF7">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126">
        <property type="entry name" value="ANKYRIN REPEAT, PH AND SEC7 DOMAIN CONTAINING PROTEIN SECG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="150"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="183"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="216"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="249"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="39"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005023987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="317" mass="35913" checksum="8ACEA9AAB9D5A2A7" modified="2022-01-19" version="1">MMMMKVEELVTGKKTDDKDTSSFLPEDFKTGEYEAEVKLEKQDDLKTASDHLPTQADMGHAKKQHEAELKKKLQEKSKLESLEDLEKIIQLKKKKKCRKVKAPLLKEPEPEVITGPVDIAMFFRAALENKLPVIEKYLLDKGDPNVCDEYKRTALHRACSEGHLEVVKKLVEAGALLELKDMLGSTALHWACRGGNLDIVKFLLDKGMNRNARDKLLSTPLHVAVRTGKYDCAEHLIACEADLNAKDREGDTPMHDAVRLNRYKIVRLLILHGANLTIKNGDGKTPMDLVLQWQNGTKELFNNLKNNSYKNTPLNKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U699</accession>
    <name>A0A8C2U699_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">PR domain zinc finger protein 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">PR domain-containing protein 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">ZNF488</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015722347.1">
        <property type="nucleotide sequence ID" value="XM_015866861.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015722348.1">
        <property type="nucleotide sequence ID" value="XM_015866862.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U699"/>
    <dbReference type="Ensembl" id="ENSCJPT00005032631.1">
        <property type="protein sequence ID" value="ENSCJPP00005023886.1"/>
        <property type="gene ID" value="ENSCJPG00005018873.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107315918"/>
    <dbReference type="KEGG" id="cjo:107315918"/>
    <dbReference type="CTD" id="118738"/>
    <dbReference type="GeneTree" id="ENSGT00890000139463"/>
    <dbReference type="OrthoDB" id="5814089at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014003">
        <property type="term" value="P:oligodendrocyte development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.270.10:FF:000012">
        <property type="entry name" value="PR domain zinc finger protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052296">
        <property type="entry name" value="TR-Histone_Methyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16516">
        <property type="entry name" value="AGAP007109-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16516:SF5">
        <property type="entry name" value="ZINC FINGER PROTEIN 488"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21549">
        <property type="entry name" value="PRDM2_PR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="19">
        <location>
            <begin position="6"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="469"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="511"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="216"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="250"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="295"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00067591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00082172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005023886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="534" mass="60830" checksum="4140BC9C70EC1C92" modified="2022-01-19" version="1">MMELTSLPKFLWTSDNKLLHHHFPDILATVHTTQDIPEEAVFGPCMLQNTLLDTVAFIALKCSDRRTIHYVFKVDVASVHSPTGLPWMRLVQAAANSKEQNLEAYLENSQLYYRSTRKINKDEELFVWYDEELSRLLGFNEIKAQSPQNEMRCQECNRVFKGEHSYLSHVRFLCVPEKSALLWRNFQAEKGTLVEQTTNFHSLAKDLEVRMTAHKGDAHGLTGEKRAKSEEAENNRSRKTVLLEKTNNLSEEHKCGSKEEAGGDHAPAGSFWKPSSGRQSARKEAFEQKQSAFTEVRRMKEKLRNERPKESDQEDGTALAGKEQVSKEMLLNSSGSAFSFVWPTRGRGEQKSAFSKPSKRLAERAAINSYPTSESPKSLEELSGFITTTDIMCCSTLLSSKFFVNDLCNAQMLQTSIIRGNVFPYSSEPWHKQAGQLQNTTTTSSSTSTSSSLTLLPPTFTSFGVAAQNWCAKCNLSFRMTSDLVFHMRSHHKKEYSSTESQSKRRREEKLTCPICHEYFRERHHLSRHMTSHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U7U0</accession>
    <name>A0A8C2U7U0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sulfotransferase</fullName>
            <ecNumber evidence="11">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">CHST7</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="11"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2U7U0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005031840.1">
        <property type="protein sequence ID" value="ENSCJPP00005023201.1"/>
        <property type="gene ID" value="ENSCJPG00005018442.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162231"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008459">
        <property type="term" value="F:chondroitin 6-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001517">
        <property type="term" value="F:N-acetylglucosamine 6-O-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050650">
        <property type="term" value="P:chondroitin sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016469">
        <property type="entry name" value="Carbohydrate_sulfotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051135">
        <property type="entry name" value="Gal/GlcNAc/GalNAc_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10704">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10704:SF5">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005883">
        <property type="entry name" value="Carbohydrate_sulfotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="13">
        <location>
            <begin position="264"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="63"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="307"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005023201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="494" mass="55460" checksum="F18B1FEDDB818657" modified="2022-01-19" version="1">MKGRRRWCWRGEHRRLALLLALYTLLLLLLVPYVLDYGARRARADEEPLLRRCPSLEEALSEWGWEQRPPPPGDDEEEEEEATAAGNGSGAGKRHIYLHATWRTGSSFLGELFNQHPDVFYLYEPMWHLWQALYPGDALSLQGALRDMLRSLFRCDFSVLRLYAAPAAPRDPLGAAPPAANLTTAGIFGWRTNKVICSAPLCPAAPLPRREIGLVDGAACERRCPPRALRELEAECRKYPVVVIKDVRLLELGALLPLLREPGLNLRVVQLFRDPRAVHNSRLKAKQALLRESIQVLRSRHRAAEPRGPPRPQQPPLPPGLGLLGAGRAPAQHRAELFLGGALEVICQAWLRDLLLARRNPAALRRRYTQLRYEDLVREPRAQLRRLLRFAGLPVPPAMEAFVVNMTRGAAYSSERPFLISARDAREAVHAWRERLSRQQVRQVEAACGEAMSLLAYPLSAGERRGEETLTPSLGTNAVWSMLCVLLCGQQVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U8E9</accession>
    <name>A0A8C2U8E9_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kinase non-catalytic C-lobe domain-containing protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Protein very KIND</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Ras-GEF domain-containing family member 2</fullName>
        </alternativeName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">RAS-Guanine nucleotide exchange factor (GEF) that controls the negative regulation of neuronal dendrite growth by mediating a signaling pathway linking RAS and MAP2. May be involved in cellular senescence.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts (via KIND2) with MAP2; the interaction enhances MAP2 phosphorylation and localizes KNDC1 to dendrites.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Dendrite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Perikaryon</location>
        </subcellularLocation>
    </comment>
    <dbReference type="Ensembl" id="ENSCJPT00005033765.1">
        <property type="protein sequence ID" value="ENSCJPP00005024786.1"/>
        <property type="gene ID" value="ENSCJPG00005019514.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000011408"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032045">
        <property type="term" value="C:guanyl-nucleotide exchange factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043204">
        <property type="term" value="C:perikaryon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048814">
        <property type="term" value="P:regulation of dendrite morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000694">
        <property type="entry name" value="Kinase non-catalytic C-lobe domain containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000529">
        <property type="entry name" value="Kinase non-catalytic C-lobe domain-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.840.10:FF:000013">
        <property type="entry name" value="Kinase non-catalytic C-lobe domain-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.870.10:FF:000014">
        <property type="entry name" value="Kinase non-catalytic C-lobe domain-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011019">
        <property type="entry name" value="KIND_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029899">
        <property type="entry name" value="KNDC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21560:SF0">
        <property type="entry name" value="KINASE NON-CATALYTIC C-LOBE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21560">
        <property type="entry name" value="VERY KIND PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16474">
        <property type="entry name" value="KIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00750">
        <property type="entry name" value="KIND"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51377">
        <property type="entry name" value="KIND"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 13" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="KIND" evidence="16">
        <location>
            <begin position="33"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="KIND" evidence="16">
        <location>
            <begin position="545"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="15">
        <location>
            <begin position="1397"/>
            <end position="1522"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="14">
        <location>
            <begin position="1622"/>
            <end position="1873"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00059522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00064286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00073176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00075611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00081643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005024786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1903" mass="213244" checksum="193BCFCA85EE9078" modified="2022-01-19" version="1">MEAAAEDGFYEEVEVNCYDFEPLPTLLEDEENVSLADILSLRDSCLTEQDIWAICLECCHSLKSIAHSAIFQTLCITPDTLAFNTNGNVCFMEQLSDDPEGAFVPPEFDITGNTFEAHIYSLGATLKAAIEYIVEPETESEFGQDLHTLLEQMQEENPENRPDIESILSLCEEKLKIASSSSICRSLSAVGRRVLSIESFGASQDACDNMWKGRVFQKSLGSKLYSNEIHNIGDSPAAEDVAATCHKDSSVVPVVTGRESSLKEKQIDLDNEKTQHSLLTTEEKKSKEDKHVEYTNGFASVALDIKSCDNDLERDGVFKKGSLRKIKTFPKLPLEPTDTNHFFTSVTNSGPLAKKNHLLMHESLPLDNNNEVGFSKGNLNSLAVNIPTKTEPKHHQVTDLHLEASCVRTQVSGMNLEEHISLISGKKIGFISSDLKEDCSDATSEVSNTAGMLKSPNLSITGAKKLDNCMALEDCTETSQGSNDNSLSHFNKMTSVLTTKPSGSRYGSNLIRSPELSSGALSANNNEDNLCGGRGSEIRSNEQWISLKLLLSWYGKPLKDHELWALCYECLRTLHTCTDYPVILCLDTVLLDCHGRVLFTAPKAEESCDIIYLAPEIEEEDVDTEKVCIYGVAAVLWMAAKYSISPNHKLTLPRKLKNLLLDMAKKNPEERPSVADAIKTCSHYLLEQGVNSKNILALLNKSVFKAVDEDIISSPNNVAFEIENEKLEMNPPESSLGFMPITRESKLIAVKGPVPCQISGQTALPVAFTSPATHFKPIILQQNANITKEVHIPPTEKFKEKLRKEKNIDCNKSGYVEGSKSYDIKDTDVVETTSEIPECRLEVPGHSFQMSLEKEETGNVFTSDSSRILQERKKLFEVPSSSLTSLKSPNSLHINNIILKQNSEKRVLTFVPVHLAVSEQIPNKPLHSRVASDCSHSLPVLLSSTIASYKLSMQTQNDSSLLKVQNSMTINTQNVSEKNDQVLQTNCQDIEGATNTGSSFSEQGLTTCTSVVQVVQEAKEASCVFDEEVLSQQRRTNDTLLQKVIHLIQEEFAFDGYLENGVEVFDMGNFILALKEIEFSVFSDKICEKYCDLYWDEKLLENLYQVVNGERASPLHITEADDSNCGGVFQDLKKSDSFLASSDHTEGEGEATFEVKDDLMINTSLAEMNLNEMPLDNFIKESWLQNAIPIEKDGQCLQSNGYCIGPDFAEEITEPEEEAVIKTPENSYVVTPNPPDFHGCSPGWSSAFYGAECFDSEVHSYIKNLGKQKSNESQSIDAKKVELEQLLMMETKNYRKTIKFYQKLLQKERRNKGPETKSMLPKLRGQLQEMKSRVQFLELVKKCVQIMYAEQWGVETSILPIIIHNGRTDIIDVAPTDESSVLVYYNTEKHKCNNQNGIRVLQAGTPLGLMAYLYSRNAFLEGYVQQFLYTFRYFCTQEEFLQFILDRISSTLSSASLDPSSSLTKICNRSFCILQAWIEDCYNVDFATNVNLLHTLKEFISSKVAPLNGYGEHLLTLLEDASARKCGSSQQCSSMENGEEEEEEERKTLHSICKKLSEDMFRKNFNWKLSKGMGPIAHYQRERLYTISSVLPKPCYSSFTEEFPVSFAKADEVGPYLLTEYSVQQLCCQLTLLQQELFHKCHPVHFLNSRALGVKDKCAAVQKAAATEEVSFKVCNLFLSKCIQDQYLIQLLRNADSVSTWVAAEIVTCHTSKLQVSLLSKFLLIAKSCYEQRNFATAMQILAGLENLIVRQLPAWKILPAKVAEIIEELKAVEVFLKSDSLCLMEGERFKTLPTIPSAHVLAMHVQQLETGGFTMTNGAHKWTKLRNIAKVVSQVHAFQENPYTFTPDYKLQSYLRQRITRFKDADISALAADNCANFHHIPAEKHSRKIQDTLRRMKATFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U910</accession>
    <name>A0A8C2U910_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Bactericidal permeability-increasing protein</fullName>
            <shortName evidence="8">BPI</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BPIFC</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer. Homodimer; disulfide-linked.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The N- and C-terminal barrels adopt an identical fold despite having only 13% of conserved residues.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">The N-terminal region may be exposed to the interior of the granule, whereas the C-terminal portion may be embedded in the membrane. During phagocytosis and degranulation, proteases may be released and activated and cleave BPI at the junction of the N- and C-terminal portions of the molecule, providing controlled release of the N-terminal antibacterial fragment when bacteria are ingested.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2U910"/>
    <dbReference type="Ensembl" id="ENSCJPT00005031369.1">
        <property type="protein sequence ID" value="ENSCJPP00005022887.1"/>
        <property type="gene ID" value="ENSCJPG00005018190.1"/>
    </dbReference>
    <dbReference type="KEGG" id="cjo:107314491"/>
    <dbReference type="GeneTree" id="ENSGT01150000286994"/>
    <dbReference type="OrthoDB" id="9938407at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050829">
        <property type="term" value="P:defense response to Gram-negative bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.15.20.10:FF:000001">
        <property type="entry name" value="Phospholipid transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.15.10.10:FF:000001">
        <property type="entry name" value="phospholipid transfer protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.20.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017943">
        <property type="entry name" value="Bactericidal_perm-incr_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030675">
        <property type="entry name" value="BPI/LBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032942">
        <property type="entry name" value="BPI/LBP/Plunc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001124">
        <property type="entry name" value="Lipid-bd_serum_glycop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017954">
        <property type="entry name" value="Lipid-bd_serum_glycop_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017942">
        <property type="entry name" value="Lipid-bd_serum_glycop_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10504">
        <property type="entry name" value="BACTERICIDAL PERMEABILITY-INCREASING BPI PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10504:SF17">
        <property type="entry name" value="BPI FOLD-CONTAINING FAMILY C PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01273">
        <property type="entry name" value="LBP_BPI_CETP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02886">
        <property type="entry name" value="LBP_BPI_CETP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002417">
        <property type="entry name" value="Lipid_binding_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00328">
        <property type="entry name" value="BPI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00329">
        <property type="entry name" value="BPI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55394">
        <property type="entry name" value="Bactericidal permeability-increasing protein, BPI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00400">
        <property type="entry name" value="LBP_BPI_CETP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0044">Antibiotic</keyword>
    <keyword evidence="8" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="5 7 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0391">Immunity</keyword>
    <keyword evidence="8" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 8 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034336434" description="Bactericidal permeability-increasing protein" evidence="9">
        <location>
            <begin position="21"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Lipid-binding serum glycoprotein N-terminal" evidence="10">
        <location>
            <begin position="27"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Lipid-binding serum glycoprotein C-terminal" evidence="11">
        <location>
            <begin position="262"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="152"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR002417-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU369039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005022887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="469" mass="52559" checksum="91BB38F30DAB3B8B" modified="2022-01-19" version="1">MVKICCSLLLLSLLSVQLKANPGLKVRITQKALEYAKEVGLEILKKNMEKEQFPDLTGYERFGLGNVNYNISRIRVTAVEFPNVSISLMPRSGVKLVIRNASLTIDMNWNIRTWMFKDGGRSTVHISKVFVTAMFSTPLDRMGHTSIPLISCHTTPGDTDIKLNGKSGFLHDFFIKYLKKPIHRRLATNSCPNIKSGIRLIAKDLQSLNVPVRIDDLAEIDYSLNNLEVFRPHIDMDLKGIVYPAGNYTGPPYVAAPFAIPDQNDSMLYLAFSEYFFQTSLFSYYTAGAFNITIEKETCRYLNINTEMFGSIIPEIAKYSVVPYPVMVKLMATEIPLVSLQQDSFTLEILESMEVFAVLPDSNNQSLFTVNVAANTSVALNVFDQKLTGSLCLNRLQFSLIHSNVGSFEISFLENVLSYILQTEVIPSANAKLSRGFPLPNLANVTLTRPHITIAQGYVLISTDVHYKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U9Q3</accession>
    <name>A0A8C2U9Q3_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ABI gene family member 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">New molecule including SH3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ABI3</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="7">May interact with PAK1 and PAK2. Probably interacts with TARSH.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABI family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2U9Q3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005033465.1">
        <property type="protein sequence ID" value="ENSCJPP00005024573.1"/>
        <property type="gene ID" value="ENSCJPG00005019354.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161380"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098858">
        <property type="term" value="C:actin-based cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031209">
        <property type="term" value="C:SCAR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002357">
        <property type="term" value="P:defense response to tumor cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010593">
        <property type="term" value="P:negative regulation of lamellipodium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903077">
        <property type="term" value="P:negative regulation of protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001764">
        <property type="term" value="P:neuron migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000774">
        <property type="term" value="P:positive regulation of cellular senescence"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030334">
        <property type="term" value="P:regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000170">
        <property type="entry name" value="ABI gene family member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028457">
        <property type="entry name" value="ABI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012849">
        <property type="entry name" value="Abl-interactor_HHR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10460:SF7">
        <property type="entry name" value="ABI GENE FAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10460">
        <property type="entry name" value="ABL INTERACTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07815">
        <property type="entry name" value="Abi_HHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
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        <property type="entry name" value="P67PHOX"/>
    </dbReference>
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        <property type="entry name" value="SH3"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="12">
        <location>
            <begin position="332"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="175"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="191"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="243"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00063868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00074771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00080253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005024573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="389" mass="41405" checksum="0054B441B8BE5963" modified="2022-01-19" version="1">MVLSIAESHCLSWRNCDAFGKQKEAPLLPCDPGLGMTAAALCALSHPSSSQLCFTLQASDKRKALEETMAFSTQSLASVAYQVSSLATTFLQLLDLQAAELQKLEANVSCVAQSVDMHKEKVSRREIGALTVSKRFPSHQKITSPPNPPSLEPYYRKPLNFSILDDIGHGIKDHSTQLSRTGTLSRKGMKITTQSAGTMGRSTRVPEPIQPPVVPEGKLSAASSASSLTSISSSGGAPGEGIPAPPPLPPLPGPPPTPAAATIPPPPPLPGDLLPPPPPPGDLDVPPPDFSLPVSNDPESPLPPPPPLPNFEDFTPPPPPPAAEEPSCVPESYLDKVLTIYPYTRQKDNELSFEPGALIYVTRRYSDGWCEGIMGEEAGFFPGNYVEPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U9Y6</accession>
    <name>A0A8C2U9Y6_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AFG2 AAA ATPase homolog B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">AFG2B</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U9Y6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005034785.1">
        <property type="protein sequence ID" value="ENSCJPP00005025584.1"/>
        <property type="gene ID" value="ENSCJPG00005020074.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160700"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="C:VCP-NPL4-UFD1 AAA ATPase complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:ATP hydrolysis activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
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    </dbReference>
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        <property type="term" value="F:preribosome binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051228">
        <property type="term" value="P:mitotic spindle disassembly"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd19503">
        <property type="entry name" value="RecA-like_CDC48_NLV2_r1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000038">
        <property type="entry name" value="spermatogenesis-associated protein 5-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001081">
        <property type="entry name" value="Spermatogenesis-associated protein 5-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001161">
        <property type="entry name" value="spermatogenesis-associated protein 5-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF194">
        <property type="entry name" value="ATPASE FAMILY GENE 2 PROTEIN HOMOLOG B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="223"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="484"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005025584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="748" mass="81672" checksum="080145F7E4BD1F31" modified="2022-01-19" version="1">MDPVSLRLLPPDPRDEGTQRCRLGPAALSSLGVVLGAPLRISLPSGCCLCTAWPRPDLADGYVQADPACSTGLTLAALRELSLSPGCFQPLSARRLRGAAVRVVLRGGAARRAAGLQEAVRDLLSNLYVSPHYVVTVGPNVRTPVVHIEILSVEPATEEAGLITSQTNVTIKEVMALERYRLLTEETAKIPVAGLDDVRESLIEMVDLPFRFPRTFNKLGLPVPNGVLLVGPPGVGKTLLVKAVARDVGADLLCISGPALCGSRPGESEENLRRVFEKGREMSWEGPTLLFIDEIDALCPKRGSSNSAPEDRLVAQLLTLLDGVGRKDRMVVVAATNRPDALDPALRRPGRFDREVIIGTPTLTQRRSILQMLTCSMPISADIDLVKLAEMTTGYVGADLTALCREAAMQAVFHTEVLINMSDFQEAFKRIQPSSFRSAIGLKECKPVTWEQIGGLEDVKLKLKQSVEWPMKFPQAFVRMGLSRPKGVLLYGPSGCAKTTLVKAVATSCHCSFLSVSGAELFSPYVGDSEKILSQVFRQARANSPAIIFLDEIDSILGSRSHSKTGRGVSERVLSVLLNELDGVGLKVTERRGNKLQLEERCEEPSDEERQLEFQETLSRDIMVVAATNRPDVLDDALLRPGRLDRVIYIPPPDLKGRLSILKVCTEKIPLDTDVSLQDLAALTDLFSGADIENLCREAALLALQENGLEVTAVKHEHFVKSLQTVKPSLSMKDLEFYENMYSRELTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UAD2</accession>
    <name>A0A8C2UAD2_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Progesterone immunomodulatory binding factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">PIBF1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015707135.1">
        <property type="nucleotide sequence ID" value="XM_015851649.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UAD2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005033890.1">
        <property type="protein sequence ID" value="ENSCJPP00005024892.1"/>
        <property type="gene ID" value="ENSCJPG00005019585.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107308065"/>
    <dbReference type="KEGG" id="cjo:107308065"/>
    <dbReference type="CTD" id="10464"/>
    <dbReference type="GeneTree" id="ENSGT00390000015293"/>
    <dbReference type="OrthoDB" id="299638at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005136">
        <property type="term" value="F:interleukin-4 receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007080">
        <property type="term" value="P:mitotic metaphase chromosome alignment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032695">
        <property type="term" value="P:negative regulation of interleukin-12 production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032815">
        <property type="term" value="P:negative regulation of natural killer cell activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031393">
        <property type="term" value="P:negative regulation of prostaglandin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032733">
        <property type="term" value="P:positive regulation of interleukin-10 production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071539">
        <property type="term" value="P:protein localization to centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026205">
        <property type="entry name" value="PIBF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18950:SF0">
        <property type="entry name" value="PROGESTERONE IMMUNOMODULATORY BINDING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18950">
        <property type="entry name" value="PROGESTERONE-INDUCED BLOCKING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="60"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="198"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="481"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="584"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005024892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="761" mass="90131" checksum="6541A5D294EB9EB6" modified="2022-01-19" version="1">MSRKSAKEGRKVNISSSLESEDISLETTVPTDELSSSEEREGATRVTRQLIERKELLHNLQLLKIELSQKNLMIDNLKVEYLTKIEELEEKLNDAIHQKQLLSLRLDSQLTLQQEDARKHQALMKQEMETILLRQKQLEETNHQLRERAGDIRRSLRDLELTEDGYEKLKSLSEDQLSIPEYVSIRFYEVVHPLRKELGDLQMKKETLTEEVSEYRSQLKSLTESYENERRSRSELEVKCQRLILELADTKQMIQQGDYRQENYDKVKCERDVFEHELSELRRKYEILEMSHKAQTKERNDLSKELATIQQSLNLLQKDKDYLNRQNMELSVRCAHEEDRLERLQIQLEDAKKAREEMYEKYVASRDHYKTEFEKRLHEELEQIRLKTNQEIEQLRSASKEMYERENRNLREARDNAVAEKERAVTAERDALRKYDQLLEQYRQMQLGTESKVAELLHQSKLKSFESEHIQLMQQETAKNLSQCQIECEKYQRKLEVLTKEFYSLQSSSETRIIELQTQNSEFQARLDTYEKLEKDLDEIIMQTAEMENEVEAERVLFSYGYGANVPTTAKRRLKQSVHLARRLLQLEKQNSLLVKDLEHQKEQVTQISQELDRANSLLSQVQQPYKYLIGTVQQRDSQISVQKEHIAELEKDVSLLNKEKTALLRVKNQMAADLERLLNHREELAVMKQILIKLQDKHKEQNLPPSQINLKTLTAENKLSPSVKLLPEHEEENIFRPKPTLFTNIQAPVWYKKLQKKTSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UAW7</accession>
    <name>A0A8C2UAW7_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Potassium voltage-gated channel interacting protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">KCNIP2</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the recoverin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2UAW7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005034220.1">
        <property type="protein sequence ID" value="ENSCJPP00005025132.1"/>
        <property type="gene ID" value="ENSCJPG00005019751.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157798"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071193">
        <property type="term" value="C:Kv4.2-KChIP2 channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005250">
        <property type="term" value="F:A-type (transient outward) potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015459">
        <property type="term" value="F:potassium channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044325">
        <property type="term" value="F:transmembrane transporter binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045163">
        <property type="term" value="P:clustering of voltage-gated potassium channels"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0086009">
        <property type="term" value="P:membrane repolarization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006936">
        <property type="term" value="P:muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903766">
        <property type="term" value="P:positive regulation of potassium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060306">
        <property type="term" value="P:regulation of membrane repolarization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000043">
        <property type="entry name" value="Kv channel-interacting protein 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF65">
        <property type="entry name" value="KV CHANNEL-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="7" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="7" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="domain" description="EF-hand" evidence="14">
        <location>
            <begin position="122"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="14">
        <location>
            <begin position="158"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="14">
        <location>
            <begin position="206"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005025132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="328" mass="36714" checksum="F3CAEAAE9BA90F02" modified="2022-01-19" version="1">MRSKGRKESLSDSRDLDGSYDQLTGNPPGQTKKALKQRFLKLLPCCRPKSIPSLSENSVEDEFELSTVCHRPEGLEQLQEQTKFTRKELQVLYRGFKNECPSGIVNEENFKQIYSQFFPQGDSSTYATFLFNAFDTDHDGSVSFEDFVSGLSIILRGTIDDRLNWAFNLYDLNKDGCITKEEMLDIMKSIYDMMGKYTYPAMREEAPREHVENFFQKMDRNKDGVVTIEEFLESCQKVKPWGSAQHSWGSALGAMFMPSSLCGWGTAHPSMALVSLGAPVLCVRAAGRDYPWGNTRFGGAAQSAALCPNTPPPCRMRTSCGPCSSSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UBW4</accession>
    <name>A0A8C2UBW4_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UBW4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005033056.1">
        <property type="protein sequence ID" value="ENSCJPP00005024224.1"/>
        <property type="gene ID" value="ENSCJPG00005019125.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005024224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="303" mass="33292" checksum="3633F6EC07743193" modified="2022-01-19" version="1">MAPVPSSPFCSLPNSAAAPTPSSGWGSFLGGLPLAEHLLGAGLSPAWIWGDQVSLWLLGWLWGTQCNTDFVFGGSVGCTVRNQWGLAVSRWRWALKRCNKQSCASCPAAAKATGVLAVLGVPRFRRICTPMSWLKLQSMLSYVGWARTVHVIPFGFVHMGLSYMGLLYIDLSYKALYYEGFSTWVCPTWFCPTWVCPTWFCPTWVCPTWVCPTWVCPTWVCPTWVCPTWFCPTWVCPTYGSVLHGFVLHGFVLHGSVLHGLLSAVSGTFSCPAGGIPTDGNSTTVTGMSPWLRDTQNQWEGCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UCW9</accession>
    <name>A0A8C2UCW9_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">General transcription factor IIH subunit 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">General transcription factor IIH polypeptide 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">GTF2H3</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Part of a TFIID-containing RNA polymerase II pre-initiation complex that is composed of TBP and at least GTF2A1, GTF2A2, GTF2E1, GTF2E2, GTF2F1, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2B, TCEA1, ERCC2, ERCC3, TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. Component of the 7-subunit TFIIH core complex composed of XPB/ERCC3, XPD/ERCC2, GTF2H1, GTF2H2, GTF2H3, GTF2H4 and GTF2H5, which is active in NER. The core complex associates with the 3-subunit CDK-activating kinase (CAK) module composed of CCNH/cyclin H, CDK7 and MNAT1 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription. Interacts with RARA; the interaction requires prior phosphorylation of RARA on 'Ser-369' which then enhances interaction of RARA with CDK7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the TFB4 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2UCW9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005034498.1">
        <property type="protein sequence ID" value="ENSCJPP00005025351.1"/>
        <property type="gene ID" value="ENSCJPG00005019908.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000013143"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000438">
        <property type="term" value="C:core TFIIH complex portion of holo TFIIH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004600">
        <property type="entry name" value="TFIIH_Tfb4/GTF2H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12831:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12831">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIH TFIIH , POLYPEPTIDE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03850">
        <property type="entry name" value="Tfb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005025351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="163" mass="18267" checksum="8F0AE0D80544F85B" modified="2022-01-19" version="1">MSKEVKANQEMKSRILVIKAAEDSALQYMNFMNVIFAAQKQVNILIDACVLDSDSGLLQQACDITGGIYLKVPHLPSLLQYLLWVFLPDQEQRSQLVLPPPVHVDYRAACFCHRNLIEIGYVCSVCLSIFCNFSPICSTCETAFKISLPPVMKAKKKKLKLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UD59</accession>
    <name>A0A8C2UD59_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cyclin-dependent kinase 2-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">CDK2AP1</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the CDK2AP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015733229.1">
        <property type="nucleotide sequence ID" value="XM_015877743.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UD59"/>
    <dbReference type="Ensembl" id="ENSCJPT00005034601.1">
        <property type="protein sequence ID" value="ENSCJPP00005025447.1"/>
        <property type="gene ID" value="ENSCJPG00005019964.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107321137"/>
    <dbReference type="CTD" id="8099"/>
    <dbReference type="GeneTree" id="ENSGT00940000155149"/>
    <dbReference type="OrthoDB" id="9628807at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016581">
        <property type="term" value="C:NuRD complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070182">
        <property type="term" value="F:DNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017266">
        <property type="entry name" value="DOC_1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22607:SF2">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 2-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22607">
        <property type="entry name" value="DELETED IN ORAL CANCER 1/CDK2-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09806">
        <property type="entry name" value="CDK2AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037709">
        <property type="entry name" value="CDK2-associated_p2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR037709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005025447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="122" mass="13102" checksum="71C82616B3168202" modified="2022-01-19" version="1">MSLGMSYKPNLNAHIPGTPLGPAGSVHSPSTSMATSAQYRQLINDYGPPSLGYTQGIQGTSSSQVPQSKYAELLAIIEELGKEIRPTYAGSKSAMERLKRGIIHARGLVRECLAETERNARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UDQ2</accession>
    <name>A0A8C2UDQ2_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TEPSIN adaptor related protein complex 4 accessory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">TEPSIN</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2UDQ2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005037027.1">
        <property type="protein sequence ID" value="ENSCJPP00005027385.1"/>
        <property type="gene ID" value="ENSCJPG00005021238.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000015076"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032588">
        <property type="term" value="C:trans-Golgi network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03572">
        <property type="entry name" value="ENTH_like_Tepsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035802">
        <property type="entry name" value="ENTH/VHS_tepsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039273">
        <property type="entry name" value="TEPSIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058028">
        <property type="entry name" value="Tepsin_VHS/ENTH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21514">
        <property type="entry name" value="AP-4 COMPLEX ACCESSORY SUBUNIT TEPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21514:SF0">
        <property type="entry name" value="AP-4 COMPLEX ACCESSORY SUBUNIT TEPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01417">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25827">
        <property type="entry name" value="TVHS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034223371" evidence="6">
        <location>
            <begin position="18"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="ENTH" evidence="7">
        <location>
            <begin position="35"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="AP-4 complex accessory subunit Tepsin VHS/ENTH-like" evidence="8">
        <location>
            <begin position="319"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="209"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="426"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="545"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="209"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="234"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="267"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="283"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="473"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="571"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005027385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="581" mass="60447" checksum="BC78EEA76F336DE2" modified="2022-01-19" version="1">MGGAVLWGLLGSLGSHCASFQLPVLLRGTADQEEPCPGFVLEEISKISRESAGSSQCLLEFLLGRLRGGSCHVKLKVLKILQHTCAQGSPQFVLQLRRNAAFIREAAAFTGPPDPLHGNSLNQKVRAAAQDLASFLFSDAVPPTVATCPARPLHPAGMGSKSSPCSSMQGFGFSSERGSSASAGEALLSTIQRAAEAVANAVLPSLDGPRSHCGELHEDTYQPVTAPSPARSLASSTNPPAATTAHIARVSHQPGLAGGGWEEADSGHSSQNSSQENGDLSRTSDTYSKSGSDSHSGTSRELVSGAERVDADSLGDCLREVSLVSALTQGARVFLTREEAQHFLKECGLLNCEVVLELLSRALEDPSDNVRMRSMSAISSLMCSDLLALDQIFAGTRQQLQQLSQGSPGPVANRATKILRQFEALCGGRPSPKTSRPRSAPSALTEGSAPCTGDLLTDIPPLPAESSILQPLSAPTAPSTAAAVGTQPGLEAEPWEQPGPIAVPIPHSQEAESRLGVDVGTAAAPTRSLSLFAGMELVAAPSTALSLHPAPAEPRTLPQPRGDTVPDPKDSQPSAFSFLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UDR3</accession>
    <name>A0A8C2UDR3_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Actin gamma 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ACTG1</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the actin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015735544.1">
        <property type="nucleotide sequence ID" value="XM_015880058.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UDR3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005037040.1">
        <property type="protein sequence ID" value="ENSCJPP00005027397.1"/>
        <property type="gene ID" value="ENSCJPG00005021244.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107322234"/>
    <dbReference type="KEGG" id="cjo:107322234"/>
    <dbReference type="CTD" id="71"/>
    <dbReference type="GeneTree" id="ENSGT00950000182960"/>
    <dbReference type="OrthoDB" id="9240758at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10224">
        <property type="entry name" value="ASKHA_NBD_actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000131">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000291">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000047">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00406">
        <property type="entry name" value="ACTINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0558">Oxidation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005027397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="375" mass="41806" checksum="24EC51510F164FB7" modified="2022-01-19" version="1">MEEEIAALVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNTPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPEALFQPSFLGMESCGIHETTFNSIMKCDVDIRKDLYANTVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPSIVHRKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UGQ1</accession>
    <name>A0A8C2UGQ1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Sodium channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">LOC107316751</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>Na(+)(in) = Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:34963"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 18">Cell membrane</location>
            <topology evidence="1 18">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the sodium channel (TC 1.A.1.10) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSCJPT00005035520.1">
        <property type="protein sequence ID" value="ENSCJPP00005026206.1"/>
        <property type="gene ID" value="ENSCJPG00005019385.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157130"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001518">
        <property type="term" value="C:voltage-gated sodium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005248">
        <property type="term" value="F:voltage-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0086010">
        <property type="term" value="P:membrane depolarization during action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019228">
        <property type="term" value="P:neuronal action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13433">
        <property type="entry name" value="Na_channel_gate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000002">
        <property type="entry name" value="Sodium channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000001">
        <property type="entry name" value="Sodium channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000006">
        <property type="entry name" value="Sodium channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000002">
        <property type="entry name" value="Sodium channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000004">
        <property type="entry name" value="Sodium channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000005">
        <property type="entry name" value="Sodium channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1190:FF:000001">
        <property type="entry name" value="Sodium channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000003">
        <property type="entry name" value="Voltage-dependent sodium channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1190">
        <property type="entry name" value="iswi atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058542">
        <property type="entry name" value="IQ_SCN5A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001696">
        <property type="entry name" value="Na_channel_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044564">
        <property type="entry name" value="Na_chnl_inactivation_gate"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010526">
        <property type="entry name" value="Na_trans_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024583">
        <property type="entry name" value="Na_trans_cytopl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043203">
        <property type="entry name" value="VGCC_Ca_Na"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10037:SF278">
        <property type="entry name" value="SODIUM CHANNEL PROTEIN TYPE 2 SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10037">
        <property type="entry name" value="VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24609">
        <property type="entry name" value="IQ_SCN5A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06512">
        <property type="entry name" value="Na_trans_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11933">
        <property type="entry name" value="Na_trans_cytopl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00170">
        <property type="entry name" value="NACHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16 18" id="KW-0407">Ion channel</keyword>
    <keyword evidence="12 18" id="KW-0406">Ion transport</keyword>
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    <sequence length="1985" mass="226819" checksum="1E606E1FB050E0AD" modified="2022-01-19" version="1">MAQALLVPPGPESFRYFTKESLAAIEKRIADEKSNHDKNEHKDDGGHEEVQPTPNNDLEAGKTLPFIYGDIPPDMVSEPLEDLDPYYINKKTFIVLNKGKTIFRFSATPALYLLSPFNVIRRVAIKILSTLFSMLIMLTILTNCVFMTWSRLPEWTKNVEYTFTGIYTFEFLVKILARGFCIDDFTCLRDPWNWLDFVVISFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKNKCLLWPSRNSTSFEKYLAPYFNGTEFDWAEYIEDESKICYNIVLLKPLVGWLLFFFFSFFSKCPEGFICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAVGKTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATMVEAEQREADLQQMLEQLKRQQEEAQMTEFGGESGPSDSSSEASKLSSKSAKERRNRRKKRRQREHSGEDDNMKDTTLSKSESDGSIRRKGFRFSFDGNKLAYGTRLTSPHQSLLSIRGSLFSPRRSSRTSLFSFRDHGKERGSENDFADDEHSAFDDNGSRRGSLFVPLKHSERRGSNISQASRSSRRLTLFPVNGKMHSTVDCNGVVSLVDRPPCLLSPTGQLLPEVKIDKPTTDDNSTTAEMEIKKRRSSSYQIPMDLLEDPNLRQRAMSIAGIITNTMEELEESRQKCPPCWYKFAHTYLIWNCCELWIRVKSVVSFIVMDPLVDLAITICIILNTLFMAMEHYPMTDTFNNTLKVGNQVFTGIFAAEMVLKIIAMDPFYYFQVGWNIFDSVIVTLSLVELFLANVDGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKISSDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQPMCLTVFMMVMVIGNLVVLNLFLALLLSSFSSDSLSPTEDDNEMNNLQIAVARIQKGIAYVKQKVGEYIQKSCWRKQVAANERTATDQINDERHHCISNCTIAEIKKDTTYHNNENGTAGVVGSSDYPLFINNPSLTVTVPIAVGESDFEHLNTEEFSSDSDLEESKEKINLSSSSEGSTVNLALFGEEKAETEPEKGAELQTCFTEGCIQKFKCCRCNIESRRGIIWWNLRKTCYRIVEHNWFETFIVFMILLSSGTLAFEDIYIEQRKTIRLILDYADKIFTYIFILEMVLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGFSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALTGAIPSIMNVLLVCLTFWLIFSIMGVNLFAGKFYYCVNTTTGLQFKPDEVDNKTMCENLRSTASEVRWKNVKVNFDNVGAGYLSLLQVATFKGWMDIMYAAVDSREVRDQPMYEYNLYMYLYFVAFIIFGSFFTLNLFIGVIIDNFNQQKKKISQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKLQGLVFDIVTKQAFDIGIMVLICLNMVTMMIETDDQSELMQNILYWINFVFVVLFTGECVFKLFSLRYYYFTVGWNIFDFVVVILSIVGMFLAKVIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGKPDCDPNKIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFGVATEESAEPLGEDDFEMFYEVWEKYDPDATQFIEYSKLSDFAAALDPPLNIPKPNKIQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESDEMDALRVQMEDRFMAANPSKVSYEPITTTLKRKQEEVSAIIIQRAYRCYLLRRSIKKLSCMYRKDGVDILSKNYMLFGKLSENSSSEKTDMTSSTTYPPSYDSVTKQEKEKYEDDKSEKEDKGKDRKGNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UHH2</accession>
    <name>A0A8C2UHH2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Tyrosine-protein kinase</fullName>
            <ecNumber evidence="14">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">SRC</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 21">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the protein kinase superfamily. Tyr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="14"/>
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    <dbReference type="SMR" id="A0A8C2UHH2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005036481.1">
        <property type="protein sequence ID" value="ENSCJPP00005026940.1"/>
        <property type="gene ID" value="ENSCJPG00005020921.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158250"/>
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        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="C:cell-cell junction"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="C:perinuclear region of cytoplasm"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="C:ruffle membrane"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:ephrin receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016004">
        <property type="term" value="F:phospholipase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043274">
        <property type="term" value="F:phospholipase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051219">
        <property type="term" value="F:phosphoprotein binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097110">
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    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005026940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="550" mass="62161" checksum="C9B0162A01D9F28D" modified="2022-01-19" version="1">MGSSKSKPKDPSQRRRSLEPPDSAHHGGFPASQTPNKTAAPDTHRTPSRSFGTVATEPKLFGGFNTSDTVTSPQRAGALAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTRKVDVSQIRLKFRWLQREGDWWLAHSLTTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNPENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFGSLQQLVAYYSKHADGLCHRLTNVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKDPEERPTFEYLQAFLEDYFTSTEPQYQPGENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UIK1</accession>
    <name>A0A8C2UIK1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">E3 ubiquitin-protein ligase RNF14</fullName>
            <ecNumber evidence="5">2.3.2.31</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">RING finger protein 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="primary">RNF14</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="27" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="27" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="19">Interacts with GCN1; interaction takes place in response to ribosome collisions and is required for ubiquitination of EEF1A1/eEF1A. Interacts with the ubiquitin-conjugating enzymes UBE2E1 and UBE2E2. Interacts with AR/androgen receptor. Interacts with TCF7/TCF1, TCF7L1/TCF3 and TCF7L2/TCF4; promoting Wnt signaling.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the RBR family. RNF14 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="5"/>
    <dbReference type="RefSeq" id="XP_015730974.1">
        <property type="nucleotide sequence ID" value="XM_015875488.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UIK1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005036453.1">
        <property type="protein sequence ID" value="ENSCJPP00005026914.1"/>
        <property type="gene ID" value="ENSCJPG00005020902.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107320041"/>
    <dbReference type="KEGG" id="cjo:107320041"/>
    <dbReference type="CTD" id="9604"/>
    <dbReference type="GeneTree" id="ENSGT00940000154507"/>
    <dbReference type="OrthoDB" id="1431934at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050681">
        <property type="term" value="F:nuclear androgen receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085020">
        <property type="term" value="P:protein K6-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160127">
        <property type="term" value="P:protein-RNA covalent cross-linking repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060765">
        <property type="term" value="P:regulation of androgen receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060828">
        <property type="term" value="P:regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006415">
        <property type="term" value="P:translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd20341">
        <property type="entry name" value="BRcat_RBR_RNF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20354">
        <property type="entry name" value="Rcat_RBR_RNF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16628">
        <property type="entry name" value="RING-HC_RBR_RNF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23820">
        <property type="entry name" value="RWD_RNF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1750:FF:000011">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.20:FF:000007">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000049">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000186">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047548">
        <property type="entry name" value="Rcat_RBR_RNF14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031128">
        <property type="entry name" value="RNF14_RING-HC_Zfn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26200">
        <property type="entry name" value="Rcat_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="23" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="16" id="KW-0804">Transcription</keyword>
    <keyword evidence="15" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="14" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="12" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 22" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RWD" evidence="25">
        <location>
            <begin position="11"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="26">
        <location>
            <begin position="212"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="24">
        <location>
            <begin position="216"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="23">
        <location>
            <begin position="346"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00062346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00067098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00075528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005026914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="468" mass="53086" checksum="9115DC6BE83A74F9" modified="2022-01-19" version="1">MSSEDREAQEDELLALASIYDEDEFKRAESAQGGETRICLELPQNFRVVVSGISAESPQSFEYTVHFLPPLVLNFELPPDYPSSSPPAFTLSSKWLSPAQLSALCEHLDNLWEENRGCVVLFAWMQFLKEETLNYLNISSPYELKMRQQGSTWGRTPSVPQDAKDCVGAVGCAAAEEGIDKRAVQDVESLSSLIREILDFDQAQRRKCFNSKMYMCNICFCEKLGSECMYFTECSHVYCKACLKDYFEIQIRDGQVHCLNCPEPNCSSVATPGQVKELVGEHLFARYDRLLLQSTLDLMADVVYCPRPACQTPVMQEPGCTMGICSCCNYAFCTACKMTYHGVSPCKLSEEKLMDLRNEYLEADEATKRLMEQRYGKRVIQKAVEEIESKQWLEKNSKSCPCCSTPIEKLDGCNKMMCTGCMQYFCWLCMASLSRADPYKHFNDPSSPCFDRLFHAMQIDGEFWEGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UJZ6</accession>
    <name>A0A8C2UJZ6_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Calcium voltage-gated channel auxiliary subunit gamma 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">CACNG5</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2UJZ6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005037146.1">
        <property type="protein sequence ID" value="ENSCJPP00005027487.1"/>
        <property type="gene ID" value="ENSCJPG00005021308.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01050000244961"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032281">
        <property type="term" value="C:AMPA glutamate receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098839">
        <property type="term" value="C:postsynaptic density membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016247">
        <property type="term" value="F:channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005245">
        <property type="term" value="F:voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099590">
        <property type="term" value="P:neurotransmitter receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098943">
        <property type="term" value="P:neurotransmitter receptor transport, postsynaptic endosome to lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051968">
        <property type="term" value="P:positive regulation of synaptic transmission, glutamatergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098970">
        <property type="term" value="P:postsynaptic neurotransmitter receptor diffusion trapping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019226">
        <property type="term" value="P:transmission of nerve impulse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.150:FF:000003">
        <property type="entry name" value="Voltage-dependent calcium channel gamma-7 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051072">
        <property type="entry name" value="CACNG_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004031">
        <property type="entry name" value="PMP22/EMP/MP20/Claudin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008369">
        <property type="entry name" value="VDCC_g5su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008368">
        <property type="entry name" value="VDCC_gsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12107">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12107:SF4">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-5 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13903">
        <property type="entry name" value="Claudin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01792">
        <property type="entry name" value="VDCCGAMMA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01793">
        <property type="entry name" value="VDCCGAMMA5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005027487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="275" mass="30828" checksum="E533FD7D006D4907" modified="2022-01-19" version="1">MSACSRKALTLLSSVFAVCGLGLLGISVSTDYWLYLEEGIVQPQNQSAEIKLSLHAGLWRVCFLAGEERGRCFTIEYVMPMNIQLTSESTVNVLKMIRSATPFPLVSLFFMFIGFILSNIGHVRPHRTILAFVSGIFFILSGLSLVVGLVLYISSINDEMLNRTKDSETFFNYKYGWSFAFSAISFLLTESAGVMSVYLFMKRYTAEDIYRPHPGFYRPRLSNCSDYSGQFLHPDAWARGRSPSDISSEASLQMNSSYPALLKCPDYDQMSSSPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y599</accession>
    <name>A0A8C2Y599_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="10">PPIase</shortName>
            <ecNumber evidence="10">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">PPIB</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding.</text>
    </comment>
    <comment type="function">
        <text evidence="10">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Melanosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the cyclophilin-type PPIase family. PPIase B subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="10"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y599"/>
    <dbReference type="Ensembl" id="ENSCJPT00005001651.1">
        <property type="protein sequence ID" value="ENSCJPP00005000937.1"/>
        <property type="gene ID" value="ENSCJPG00005001015.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158007"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034663">
        <property type="term" value="C:endoplasmic reticulum chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042470">
        <property type="term" value="C:melanosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070063">
        <property type="term" value="F:RNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060348">
        <property type="term" value="P:bone development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044829">
        <property type="term" value="P:host-mediated activation of viral genome replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030593">
        <property type="term" value="P:neutrophil chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040018">
        <property type="term" value="P:positive regulation of multicellular organism growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000001">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF477">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0697">Rotamase</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="11">
        <location>
            <begin position="54"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005000937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="223" mass="24301" checksum="90C251F75F066D56" modified="2022-01-19" version="1">MQAARRALRAGCERRTMKALVAAAALGAALLLLLPAATRADERKKGPKVTAKVFFDIRMGDEDAGRVVIGLFGKTVPKTVENFVALATGEKGFGFKGSKFHRVIKDFMIQGGDFTRGDGTGGRSIYGERFPDENFKLKHYGIGWVSMANAGKDTNGSQFFITTVKTPWLDGKHVVFGKVLEGMDVVRKVENTKTDSRDKPLKDVTIADCGTIEVEKPFAIAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y5G6</accession>
    <name>A0A8C2Y5G6_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transmembrane protein 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">TMEM11</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in mitochondrial morphogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TMEM11 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y5G6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005002255.1">
        <property type="protein sequence ID" value="ENSCJPP00005001333.1"/>
        <property type="gene ID" value="ENSCJPG00005001383.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000006617"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007007">
        <property type="term" value="P:inner mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026120">
        <property type="entry name" value="TMEM11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15099">
        <property type="entry name" value="PROTEIN PM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15099:SF2">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 11, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14972">
        <property type="entry name" value="Mito_morph_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005001333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="191" mass="21636" checksum="630C43236FCF1316" modified="2022-01-19" version="1">MACWASERLGLLGLDPLSQWVTLSSTDCYIVHEIYNGENAQDQFEYELEQALEAQYKYIVIEPTRIGDETARWITVGNCLHKTAVLAGTTCLFTPLALPVDYSHYISLPAGVLSMACCTLYGISWQFDPCCKYQVEYDAYKLSRLPLHTLTSSTPVVLVRKDDLHRKRLHNTIALAALVYCVKKIYELYAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y6D9</accession>
    <name>A0A8C2Y6D9_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome c oxidase assembly factor 6 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">COA6</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the maturation of the mitochondrial respiratory chain complex IV subunit MT-CO2/COX2. Thereby, may regulate early steps of complex IV assembly. Mitochondrial respiratory chain complex IV or cytochrome c oxidase is the component of the respiratory chain that catalyzes the transfer of electrons from intermembrane space cytochrome c to molecular oxygen in the matrix and as a consequence contributes to the proton gradient involved in mitochondrial ATP synthesis. May also be required for efficient formation of respiratory supercomplexes comprised of complexes III and IV.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome c oxidase subunit 6B family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y6D9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005005923.1">
        <property type="protein sequence ID" value="ENSCJPP00005003302.1"/>
        <property type="gene ID" value="ENSCJPG00005003528.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000004094"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042775">
        <property type="term" value="P:mitochondrial ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.140:FF:000002">
        <property type="entry name" value="Cytochrome c oxidase assembly factor 6 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.140">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042289">
        <property type="entry name" value="COA6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048280">
        <property type="entry name" value="COX6B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036549">
        <property type="entry name" value="CX6/COA6-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46690">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46690:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02297">
        <property type="entry name" value="COX6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47694">
        <property type="entry name" value="Cytochrome c oxidase subunit h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00060319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00073932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005003302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="79" mass="9505" checksum="8571F05A3462ECA7" modified="2022-01-19" version="1">MAAPTMEERKACWAARDEFWRCLDTHTEDAPRCEKLRRSFESLCPQQWVKYFDKRRDFLKYKEKLESEGFHPTETAGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y6J9</accession>
    <name>A0A8C2Y6J9_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Peroxisomal ATPase PEX6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Peroxin-6</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Peroxisomal biogenesis factor 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">PEX6</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Component of the PEX1-PEX6 AAA ATPase complex, a protein dislocase complex that mediates the ATP-dependent extraction of the PEX5 receptor from peroxisomal membranes, an essential step for PEX5 recycling. Specifically recognizes PEX5 monoubiquitinated at 'Cys-11', and pulls it out of the peroxisome lumen through the PEX2-PEX10-PEX12 retrotranslocation channel. Extraction by the PEX1-PEX6 AAA ATPase complex is accompanied by unfolding of the TPR repeats and release of bound cargo from PEX5.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="19">Interacts with PEX1; forming the PEX1-PEX6 AAA ATPase complex, which is composed of a heterohexamer formed by a trimer of PEX1-PEX6 dimers. Interacts with PEX26; interaction is direct and promotes recruitment to peroxisomal membranes. Interacts with ZFAND6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
            <location evidence="1">Photoreceptor outer segment</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y6J9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005007086.1">
        <property type="protein sequence ID" value="ENSCJPP00005004177.1"/>
        <property type="gene ID" value="ENSCJPG00005004207.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00550000074953"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001750">
        <property type="term" value="C:photoreceptor outer segment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140318">
        <property type="term" value="F:protein transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140036">
        <property type="term" value="F:ubiquitin-modified protein reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016562">
        <property type="term" value="P:protein import into peroxisome matrix, receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016561">
        <property type="term" value="P:protein import into peroxisome matrix, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006625">
        <property type="term" value="P:protein targeting to peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043335">
        <property type="term" value="P:protein unfolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd19481">
        <property type="entry name" value="RecA-like_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000109">
        <property type="entry name" value="Peroxisomal biogenesis factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000039">
        <property type="entry name" value="peroxisome biogenesis factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000059">
        <property type="entry name" value="peroxisome biogenesis factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000988">
        <property type="entry name" value="peroxisome biogenesis factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057604">
        <property type="entry name" value="DPBB_PEX6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057605">
        <property type="entry name" value="PEX6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF9">
        <property type="entry name" value="PEROXISOMAL ATPASE PEX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25395">
        <property type="entry name" value="DPBB_PEX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25394">
        <property type="entry name" value="PEX6_vert_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="6" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="22">
        <location>
            <begin position="528"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="22">
        <location>
            <begin position="802"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00057209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00065183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00078618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005004177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1053" mass="111828" checksum="97B23B010C40EB1C" modified="2022-01-19" version="1">MSSLPGRLPEWSCSVPRYLHAAWRRGSALLSLLYGPRWEPSAPALRPVSAVYPAPMAVAVLRPLDAPPADPVPVSALLLAPPSLCAAVRGRGGGLVLAVRPAGRVGAQAVLLSAVALEAAGRRGTELWLRGAVLRRLGLPAGRRVAVWPVRRPPPLLWVLLGAAGRAGRPAGGAVLARRGEALPGPGPGPGPVVLEARPALQGLLGSGTRVALAAPPPREAEAGPVAAAGAAAPCRRPAAPPLVSRFAAGRGRDEGPRLRAAPPSGGAGGGGAEVWVSRRGLMAMGLFQGEWVRVSAEGSARHHLAALLARPPAWEYPPAWEYPRNARRRTPDGAALLAPALAFNLGCEPGGGTHVCLRRYDGVPGAAEGKGSRSLLPVPPFAAELHVEMVCSPAYCTRATYDHLLYRHFQTPRLVQEGDVLCIPTFGCAEFLDGNADKFLRWPELYFKVRKVLGTVEGLQSEGYLADTQNTSLYLVGSTNSAVPSAPAYTSHEFWSSLSPAGLSDVVKEICDALRPHLTSQAAALSGAGSVLISGPSGSGKTMAVRAACSCLNLHLFKVDCVSLCGDTSAATEEKIQMAFAQAQQYHPCVLLLKDIEVLGRDRDRLGEDSRVIATLRQLLLDRDPASSSRPVLVIGSTCKPQDVPTDVQTAFLHEVKIEALSEDQRRAMLSMLTAGLPLGKEVSLAKLARRTAGFVLGDFCALLSHSSRAACTRIQALSFPGGLTEEVERDFCTAGFPVVEEDFSVALDQLHDAHSQAVGAPKIPSVSWQDIGGLHEVKKEILDTIQLPLEHPELLSLGLRRSGLLLYGPPGTGKTLLAKAVATTCTMTFLSVKGPELINMYVGQSEENVRNVFARARAAAPCIIFFDELDSLAPNRGRSGDSGGVMDRVVSQLLAELDGLHSSKEVFVIGATNRPDLLDSALLRPGRFDKLVYVGVNEDRESQLQVLSAVTRKFKLDPSVNLSSILEECPAQLTGADIYSLCSDAMMCAVKRKVEWIEEGLDTESSALVLTMEDFLQAAARLQPSVSEQELLSLGRKNGFTVLSAKALCKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y7J2</accession>
    <name>A0A8C2Y7J2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-binding protein inhibitor ID-4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Inhibitor of DNA binding 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Inhibitor of differentiation 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ID1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="6">Heterodimer with other HLH proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y7J2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005009819.1">
        <property type="protein sequence ID" value="ENSCJPP00005006202.1"/>
        <property type="gene ID" value="ENSCJPG00005005820.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162435"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032922">
        <property type="term" value="P:circadian regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19691">
        <property type="entry name" value="bHLH_dnHLH_ID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026052">
        <property type="entry name" value="DNA-bd_prot-inh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11723">
        <property type="entry name" value="DNA-BINDING PROTEIN INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11723:SF6">
        <property type="entry name" value="DNA-BINDING PROTEIN INHIBITOR ID-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="10">
        <location>
            <begin position="87"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="171" mass="17676" checksum="76335473D8AC2F26" modified="2022-01-19" version="1">MNGAGSAVPAPSALLLVSALPEAPPPRWRRSIIGAARHAAPTAARRVPAPPLAMKVASTAPSPLPAGPGGALKAVRPGEAARCGPGPGAVAAEQAAAALLYDMKGCYSRLRALVPTLPRHRRVSKVELLQHVIDYIWDLQLALQPGPARPPNPAEPPEAPCMAAADRILCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y7Q4</accession>
    <name>A0A8C2Y7Q4_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Amyloid beta like protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">APLP2</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the APP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y7Q4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005010323.1">
        <property type="protein sequence ID" value="ENSCJPP00005006562.1"/>
        <property type="gene ID" value="ENSCJPG00005006118.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063252"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099503">
        <property type="term" value="C:secretory vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140677">
        <property type="term" value="F:molecular function activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007409">
        <property type="term" value="P:axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007417">
        <property type="term" value="P:central nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010604">
        <property type="term" value="P:positive regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051246">
        <property type="term" value="P:regulation of protein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd21709">
        <property type="entry name" value="JMTM_APLP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22607">
        <property type="entry name" value="Kunitz_ABPP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.140:FF:000001">
        <property type="entry name" value="Amyloid beta (A4) protein b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.570.10:FF:000001">
        <property type="entry name" value="Amyloid beta A4 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.770:FF:000001">
        <property type="entry name" value="Amyloid beta A4 protein-like isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.10:FF:000003">
        <property type="entry name" value="amyloid-like protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.770">
        <property type="entry name" value="Amyloid precursor protein, E2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.140">
        <property type="entry name" value="Amyloidogenic glycoprotein, copper-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.570.10">
        <property type="entry name" value="Amyloidogenic glycoprotein, heparin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036669">
        <property type="entry name" value="Amyloid_Cu-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008155">
        <property type="entry name" value="Amyloid_glyco"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011178">
        <property type="entry name" value="Amyloid_glyco_Cu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024329">
        <property type="entry name" value="Amyloid_glyco_E2_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008154">
        <property type="entry name" value="Amyloid_glyco_extra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015849">
        <property type="entry name" value="Amyloid_glyco_heparin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036454">
        <property type="entry name" value="Amyloid_glyco_heparin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019745">
        <property type="entry name" value="Amyloid_glyco_intracell_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019543">
        <property type="entry name" value="APP_amyloid_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019744">
        <property type="entry name" value="APP_CUBD_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036176">
        <property type="entry name" value="E2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020901">
        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23103">
        <property type="entry name" value="ALZHEIMER'S DISEASE BETA-AMYLOID RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23103:SF14">
        <property type="entry name" value="AMYLOID BETA PRECURSOR LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10515">
        <property type="entry name" value="APP_amyloid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12924">
        <property type="entry name" value="APP_Cu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12925">
        <property type="entry name" value="APP_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02177">
        <property type="entry name" value="APP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00203">
        <property type="entry name" value="AMYLOIDA4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00759">
        <property type="entry name" value="BASICPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00006">
        <property type="entry name" value="A4_EXTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56491">
        <property type="entry name" value="A heparin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89811">
        <property type="entry name" value="Amyloid beta a4 protein copper binding domain (domain 2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109843">
        <property type="entry name" value="CAPPD, an extracellular domain of amyloid beta A4 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00319">
        <property type="entry name" value="APP_CUBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51869">
        <property type="entry name" value="APP_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51870">
        <property type="entry name" value="APP_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00320">
        <property type="entry name" value="APP_INTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00280">
        <property type="entry name" value="BPTI_KUNITZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="696"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="domain" description="E1" evidence="16">
        <location>
            <begin position="50"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="15">
        <location>
            <begin position="312"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="E2" evidence="17">
        <location>
            <begin position="370"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="GFLD subdomain" evidence="12">
        <location>
            <begin position="50"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="CuBD subdomain" evidence="12">
        <location>
            <begin position="153"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="218"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="222"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="272"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="95"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="120"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="155"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="166"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="180"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="765" mass="87527" checksum="F699395CB070F169" modified="2022-01-19" version="1">MEVGAEFSVEMPEPFWCFESFCFLSGKAINLCCFSLSSQALAANAGTGFAVAEPQIAMFCGKLNMHVNIQTGKWEPDTSGTKSCFGTKEEILQYCQEMYPDLQITNVVEANQPVSIDSWCKRGKKQCKDHTHIVVPYKCLVGEFVSDVLLVPEKCRFFHKERMDVCESHQHWHTAAKEACLTEGMILHSYGMLLPCGVDQFHGTEYVCCPQTKIVDEALSKEEEDEDEDEDYDTYKSEFPTEAGVEDFTGTAVEEDEDEEDEGEEEEDVVEDRDYYYDSYKVDDYNEETTTEPTSDKAVSEKEVSSDMKSVCSQEAMTGPCRAVMPRWYFDSNKRKCIRFIYGGCGGNRNNFESEEYCMAVCKKMMPTDDVDVYFETPADDNEHARFQKAKEQLEVRHHNRMDRVKKEWEEAEHQAVNLPKAERQTLIQHFQAMVKSLEKEAASEKQQLVETHLARVEAILNDRRRIALENYLAALQAVPPRPHRIVQALKRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLRVIEERMNQSLSLLYKVPYVAEEIQDEIDELLQEQRADMDQFTSSISESQVDVRVSSEESEEIPLEGKPFRPFQVKTFPAVPENEDPQPDLYHPMKKGSGMTELDGLIGAEEKVINSKKKVDENVVIDETLDVKEMIFNAERVGGLVDEPDNDNSLRDDFSFSSSALIGLLVIAVAIATVIVISLVMLRKRQYGTISHGIVEVDPMLTPEERHLSKMQNHGYENPTYKYLEQMQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y7X3</accession>
    <name>A0A8C2Y7X3_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein phosphatase methylesterase-1</fullName>
            <ecNumber evidence="3">3.1.1.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">PPME1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[phosphatase 2A protein]-C-terminal L-leucine methyl ester + H2O = [phosphatase 2A protein]-C-terminal L-leucine + methanol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48548"/>
            <dbReference type="Rhea" id="RHEA-COMP:12134"/>
            <dbReference type="Rhea" id="RHEA-COMP:12135"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:90516"/>
            <dbReference type="ChEBI" id="CHEBI:90517"/>
            <dbReference type="EC" id="3.1.1.89"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Binds PPP2CA and PPP2CB.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.89" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y7X3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005010845.1">
        <property type="protein sequence ID" value="ENSCJPP00005006970.1"/>
        <property type="gene ID" value="ENSCJPG00005006442.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000004396"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106222">
        <property type="term" value="F:lncRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051723">
        <property type="term" value="F:protein methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051721">
        <property type="term" value="F:protein phosphatase 2A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016812">
        <property type="entry name" value="PPase_methylesterase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14189:SF0">
        <property type="entry name" value="PROTEIN PHOSPHATASE METHYLESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14189">
        <property type="entry name" value="PROTEIN PHOSPHATASE METHYLESTERASE-1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="9">
        <location>
            <begin position="235"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="411"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="411"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="545" mass="59280" checksum="3D9547C8232C53F4" modified="2022-01-19" version="1">MAPSNLALNTSKDGASTTSLCSLFQGLTTLLVKNVPLTSNLNLPSVTSTPPGSPRVCGRSPLPPVLHGSPSALPFRPRRCPATAATAGASPAFTSLPGLQLPSCIALLLNTTYTRTTFPRRPRTGAVWREALPVGAELWRPSRCVRVGEELRVLFSVMSALEKQLHLGRLPTRPPLPGGGGQSGSKMRMGPGRKRDFTPVLWSQYFESMEDVVVENETGKDTFRIYKSGLEGPVLLLLHGGGHSALSWAVFTSAIISRIQCRIVALDLRGHGETKVRNPEDLSAETMSKDVGNVVEALYGDLPPPIMLIGHSMGGAIAVHTAVANLVPSLLGLCMIDVVEGTAMDALNSMQNFLRSRPKTFKSLENAIEWSVKSGQIRNLESARVSMVGQVKQCEEAASPEGPKAIVEGIIEEEEEEEEDDEGGVSVNKRKKEDDTETKKEHLYTWRIELAKTEKYWDGWFRGLSNLFLSCPTPKLLLLAGVDRLDKDLTIGQMQGKFQMQVLPQCGHAVHEDAPDKVAEAVATFLIRHRFTEPIGGFQCVFPAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YAJ8</accession>
    <name>A0A8C2YAJ8_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ALK and LTK ligand 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ALKAL1</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ALKAL family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2YAJ8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005017702.1">
        <property type="protein sequence ID" value="ENSCJPP00005012193.1"/>
        <property type="gene ID" value="ENSCJPG00005010380.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159969"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030298">
        <property type="term" value="F:receptor signaling protein tyrosine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030971">
        <property type="term" value="F:receptor tyrosine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030297">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070374">
        <property type="term" value="P:positive regulation of ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070378">
        <property type="term" value="P:positive regulation of ERK5 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010976">
        <property type="term" value="P:positive regulation of neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029364">
        <property type="entry name" value="ALKL1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28676:SF1">
        <property type="entry name" value="ALK AND LTK LIGAND 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28676">
        <property type="entry name" value="ALK AND LTK LIGAND 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15129">
        <property type="entry name" value="ALKL1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005012193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="62" mass="7330" checksum="EFCAFC17C6A212F9" modified="2022-01-19" version="1">MSFIEGILRILKHRRPVTFSSECSKHFHRLYHNTRDCSTPAYYKRCARLLTRLAMSPLCTQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YBN1</accession>
    <name>A0A8C2YBN1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Phosphodiesterase</fullName>
            <ecNumber evidence="15">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">PDE6B</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="15">Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the cyclic nucleotide phosphodiesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="15"/>
    <dbReference type="RefSeq" id="XP_015705059.1">
        <property type="nucleotide sequence ID" value="XM_015849573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YBN1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005020617.1">
        <property type="protein sequence ID" value="ENSCJPP00005014492.1"/>
        <property type="gene ID" value="ENSCJPG00005012088.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107306419"/>
    <dbReference type="KEGG" id="cjo:107306419"/>
    <dbReference type="CTD" id="5158"/>
    <dbReference type="GeneTree" id="ENSGT00940000156471"/>
    <dbReference type="OrthoDB" id="546632at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome Z"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1300.10:FF:000005">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.40:FF:000001">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.40:FF:000010">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023088">
        <property type="entry name" value="PDEase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00387">
        <property type="entry name" value="PDIESTERASE1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0140">cGMP</keyword>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="11" id="KW-0844">Vision</keyword>
    <feature type="domain" description="PDEase" evidence="17">
        <location>
            <begin position="462"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="778"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="12">
        <location>
            <position position="538"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="538"/>
            <end position="542"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="542"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="578"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="579"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="579"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="579"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="699"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="699"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="752"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005014492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="836" mass="96686" checksum="62ECAE0B5EEE5921" modified="2022-01-19" version="1">MSISEDDVEKFLDGNPAFAKQYFEKKLKTEPCDDNESEILFELIQDMQESINMEKVVFKTLRRIRSLIHADRCSLFMYRQRNGTPELATRLFNIQEGSTLEECLVSPDCEIVYPLDLGIVGYVAQTKKTMNIKDVSECPQFSPFVDELTDYTTKSILATPILNGKDLVAVILALNKLNGPYFTNSDETLFLKYLNFASLNLKIYHLSYLHNCETRRGQVLLWSANKVFEELTDIERQFHKAFYTVRAYLNCDRYSVGLLDMTKQKEFFDLWPVLLGEVPPYSGPRTPDGREIVFYKVIDYILHGKEDIKVIPNPTPDHWALVTGLPTYVAESGFICNIMNAAADEMFNFQEGPLDESGWTIKNVLSMPIVNKKEEIVGVVTFFNRKDGKPFDEQDETLMESLTQFLGWSVLNTDTYDKMNKLENRKDIAQDMVLYHVKCDKDEIQEILPTREKLGKEPSECEEEELASILKEQLPGPTKFEIYEFRFSDFDCTELELVKCGIQMYYELGVVKKFQIPQEVLVRFVYSVSKGYRKITYHNWRHGFNVAQTMFTLLMTGKLKRYYTDLEAFAMVTAALCHDIDHRGTNNLYQMKSQNPLAKLHGSSILERHHLDFGKFLLSEESLNICQNLNRRQHEHMIHLMDIAIIATDLALYFKKRTMFQKIVDESKTYDNTTAWTDYLSLETTKKEVVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLEISVLQQQPIPMMDRRKAAELPKLQVGFIDFVCTFVYKEFSRFHEEIQPMLDGLLNNRNEWKTRADEYDAKMKALEEEKKKEEEKMAAQRDGITCNGGTAPASKTCSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YBU7</accession>
    <name>A0A8C2YBU7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2YBU7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005021105.1">
        <property type="protein sequence ID" value="ENSCJPP00005014876.1"/>
        <property type="gene ID" value="ENSCJPG00005012372.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01140000282774"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome Z"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46077">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TOPORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46077:SF1">
        <property type="entry name" value="TOP1 BINDING ARGININE_SERINE RICH PROTEIN, E3 UBIQUITIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="9"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005014876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="69" mass="7810" checksum="5789DD5B28B0A8A5" modified="2022-01-19" version="1">MAAELDHRCTICLDSMDNASYVMPCLHQFCFGCIRRWAQTRPKCPLCNGMGMHGLISCCPLMPHNEPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YEH7</accession>
    <name>A0A8C2YEH7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Gremlin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">GREM1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DAN family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2YEH7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005028490.1">
        <property type="protein sequence ID" value="ENSCJPP00005020651.1"/>
        <property type="gene ID" value="ENSCJPG00005016604.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154209"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036122">
        <property type="term" value="F:BMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030297">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043184">
        <property type="term" value="F:vascular endothelial growth factor receptor 2 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055007">
        <property type="term" value="P:cardiac muscle cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060379">
        <property type="term" value="P:cardiac muscle cell myoblast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002042">
        <property type="term" value="P:cell migration involved in sprouting angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007267">
        <property type="term" value="P:cell-cell signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030199">
        <property type="term" value="P:collagen fibril organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048263">
        <property type="term" value="P:determination of dorsal identity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030326">
        <property type="term" value="P:embryonic limb morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003337">
        <property type="term" value="P:mesenchymal to epithelial transition involved in metanephros morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900158">
        <property type="term" value="P:negative regulation of bone mineralization involved in bone maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046851">
        <property type="term" value="P:negative regulation of bone remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900155">
        <property type="term" value="P:negative regulation of bone trabecula formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032331">
        <property type="term" value="P:negative regulation of chondrocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045668">
        <property type="term" value="P:negative regulation of osteoblast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033689">
        <property type="term" value="P:negative regulation of osteoblast proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090291">
        <property type="term" value="P:negative regulation of osteoclast proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060392">
        <property type="term" value="P:negative regulation of SMAD protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045766">
        <property type="term" value="P:positive regulation of angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090190">
        <property type="term" value="P:positive regulation of branching involved in ureteric bud morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090050">
        <property type="term" value="P:positive regulation of cell migration involved in sprouting angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901224">
        <property type="term" value="P:positive regulation of non-canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002092">
        <property type="term" value="P:positive regulation of receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900748">
        <property type="term" value="P:positive regulation of vascular endothelial growth factor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009954">
        <property type="term" value="P:proximal/distal pattern formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010717">
        <property type="term" value="P:regulation of epithelial to mesenchymal transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051893">
        <property type="term" value="P:regulation of focal adhesion assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038098">
        <property type="term" value="P:sequestering of BMP from receptor via BMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060676">
        <property type="term" value="P:ureteric bud formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.90.10:FF:000013">
        <property type="entry name" value="Gremlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006207">
        <property type="entry name" value="Cys_knot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004133">
        <property type="entry name" value="DAN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017159">
        <property type="entry name" value="Gremlin-1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15283">
        <property type="entry name" value="GREMLIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15283:SF3">
        <property type="entry name" value="GREMLIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03045">
        <property type="entry name" value="DAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037254">
        <property type="entry name" value="Gremlin_precursor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00041">
        <property type="entry name" value="CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0202">Cytokine</keyword>
    <keyword evidence="6 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="CTCK" evidence="12">
        <location>
            <begin position="136"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="65"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="134"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="148"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="158"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="162"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR037254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005020651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="224" mass="25546" checksum="0B004E61FFA7A035" modified="2022-01-19" version="1">MLVAFLVHISYSACVSLQSDSGSVQRCSVTELGMLYSDNRMVRTLYAIGAVFLLMGFLLPTAEGRKRNRGSQGAIPPPDKDQPNDSEQMQTQQQSGSRHRERGKGTSMPAEEVLESSQEALHITERKYLKRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPRHVRKEEGSFQSCSFCKPKKFTTMTVTLNCPELQPPRKKKRITRVKECRCISIDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YF24</accession>
    <name>A0A8C2YF24_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Proliferation-associated SNF2-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">HELLS</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Plays an essential role in normal development and survival. Involved in regulation of the expansion or survival of lymphoid cells. Required for de novo or maintenance DNA methylation. May control silencing of the imprinted CDKN1C gene through DNA methylation. May play a role in formation and organization of heterochromatin, implying a functional role in the regulation of transcription and mitosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2YF24"/>
    <dbReference type="Ensembl" id="ENSCJPT00005029826.1">
        <property type="protein sequence ID" value="ENSCJPP00005021757.1"/>
        <property type="gene ID" value="ENSCJPG00005017251.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00740000115593"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005721">
        <property type="term" value="C:pericentric heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140463">
        <property type="term" value="F:chromatin-protein adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006346">
        <property type="term" value="P:DNA methylation-dependent constitutive heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046651">
        <property type="term" value="P:lymphocyte proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044027">
        <property type="term" value="P:negative regulation of gene expression via chromosomal CpG island methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031508">
        <property type="term" value="P:pericentric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18009">
        <property type="entry name" value="DEXHc_HELLS_SMARCA6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000015">
        <property type="entry name" value="lymphoid-specific helicase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000577">
        <property type="entry name" value="lymphoid-specific helicase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044753">
        <property type="entry name" value="HELLS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47161">
        <property type="entry name" value="LYMPHOID-SPECIFIC HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47161:SF1">
        <property type="entry name" value="LYMPHOID-SPECIFIC HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="12 18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="20">
        <location>
            <begin position="223"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="21">
        <location>
            <begin position="592"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00053349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00081399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005021757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="828" mass="95475" checksum="A77266B0D4DA3721" modified="2022-01-19" version="1">MGRGNTYHLPGPNPASAPLPEMGEQEVVITPAMLAEEEQLEAAGLEKERQMMEKARSAWDRESSEMRYKRLQHLLEKSNIYSKFLLTKMEQQQLEFKKKKSLFCQYQCFLVPSKFTVLYKLKSYVTATKKKRGRDDGTYNISEIMSKEDESSADNLCPEDLQKNGDSNSVIKDRLCQAVRHSAKQFLDPVRKFNGQPVPFQQPKIFTGGVMRWYQVEGMEWLRMLWENGINGILADEMGLGKTIQCIATIALMVERGVPGPFLVCGPLSTLPNWMSEFKRFTPEIPLMLYHGAQQERRKLVRKIHGRQGSLKIHPVVITSFEIAMRDRNALQSYFWKYLIVDEGHRIKNMNCRLIRELKRFNADNKLLLTGTPLQNNLAELWSLLNFLLPDVFDDLKSFESWFDITSVTETAEDIIAKEKEQNILHMLHQILTPFLLRRLKSDVALEVPPKREVVVYAPLAKKQETFYTAIVNRTIQNLLGNNEKEVVELSPTGRPKRRSRKLVDYCEVHNGSPDDLEKLINRTQEEVVKERPVVEVSMPMDSEVNLKLQNIMMLLRKCCNHPYLIEYPLDPATQQFKVDEDLVKNSGKFLLLDRMLPELKKRGHKVLMFSQMTRMLDVLMDYCYLRGFKFSRLDGSMSYSDREENMRQFNNDPEVFLFLVSTRAGGLGINLTAADTVIIYDSDWNPQSDLQAQDRCHRIGQTKPVVVYRLVTANTIDQKIVERAAAKRKLEKLIIHKNQFKGGKSGLAQSKSCLDPQELVELLKSRDYEREVKGSKEKVISDKDLELLLDRSDLIDQMKTSETIKKEKMGVFKVLEESSGSNAECVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YFZ0</accession>
    <name>A0A8C2YFZ0_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Interleukin 17 receptor A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">IL17RA</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2YFZ0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005032454.1">
        <property type="protein sequence ID" value="ENSCJPP00005023726.1"/>
        <property type="gene ID" value="ENSCJPG00005018768.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159018"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030368">
        <property type="term" value="F:interleukin-17 receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050832">
        <property type="term" value="P:defense response to fungus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072537">
        <property type="term" value="P:fibroblast activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071621">
        <property type="term" value="P:granulocyte chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097400">
        <property type="term" value="P:interleukin-17-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038173">
        <property type="term" value="P:interleukin-17A-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000340">
        <property type="term" value="P:positive regulation of chemokine (C-X-C motif) ligand 1 production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900017">
        <property type="term" value="P:positive regulation of cytokine production involved in inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050729">
        <property type="term" value="P:positive regulation of inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032736">
        <property type="term" value="P:positive regulation of interleukin-13 production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032747">
        <property type="term" value="P:positive regulation of interleukin-23 production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032754">
        <property type="term" value="P:positive regulation of interleukin-5 production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032755">
        <property type="term" value="P:positive regulation of interleukin-6 production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009615">
        <property type="term" value="P:response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072538">
        <property type="term" value="P:T-helper 17 type immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11530:FF:000002">
        <property type="entry name" value="Interleukin 17 receptor A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2160">
        <property type="entry name" value="Interleukin-17 receptor A/B, fibronectin-III-like domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2150">
        <property type="entry name" value="Interleukin-17 receptor A/B, fibronectin-III-like domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039465">
        <property type="entry name" value="IL-17_rcpt-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032356">
        <property type="entry name" value="IL17R_A/B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038683">
        <property type="entry name" value="IL17RA/B_FnIII-like_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043046">
        <property type="entry name" value="IL17RA/B_FnIII-like_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013568">
        <property type="entry name" value="SEFIR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15583">
        <property type="entry name" value="INTERLEUKIN-17 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15583:SF13">
        <property type="entry name" value="INTERLEUKIN-17 RECEPTOR A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16556">
        <property type="entry name" value="IL17R_fnIII_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16578">
        <property type="entry name" value="IL17R_fnIII_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08357">
        <property type="entry name" value="SEFIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51534">
        <property type="entry name" value="SEFIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="SEFIR" evidence="11">
        <location>
            <begin position="324"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="736"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="749"/>
            <end position="759"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005023726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="809" mass="91950" checksum="1FD126A97D84D1A3" modified="2022-01-19" version="1">SDSNNFPLAPFLTSFICWAGTCIERSWLQNQTWTPSAPSSLDVFSDVFRQTDGELLPVLRIEWKVATDASIRYLRGAELAVMQVSSNQQICAQFEFQNNLPLQVRPDGGRWNFTFNRFEVEPGQTYQVTVYHLPKLSVKGDYNCKSKSLTMPDCKDPLMKRTTPCIKTGSLWEPRIHAKSLDDITLLVSFNPWKEPTRYQIHVTSFLNERKCKMITHDVTEGELQPQANVTIKMEKNLRACCNYKVQIQPFFAICGTDCLRHSTFIPCSPAPNDMMMWVYWCITGICVLLVGSVIAGVICMTKKRAGKTHTVPPTDLPLPPLKPRKVWIVYSADHLLYVDVVLKFAEFLMTVCGTAVALDLLEDHQISELGPLPWLTRQKKEMEELSSKIIILCSRGTQAKWQAMLGSAPVCLKQDQQKPTGDLFTPALNLILPDFKKPACFGMYIVCYFNGISSEKDIPDLFNVTSRYQLMDKFEDIYFRIQDLEKFEPGRIHRIQEITAENYIDTPSGRKLKEAIQKFRSWQTEHPNWFEAESIGLDNVEELQSLNVESQVDSLLSEPGGIVKHQLHLREPDPNCCYVVNLHICEGENRGCKLQPQLNLCGDPASQTLIDPMDEAAPVQIVEPVSPMEDKNIFGHHVLSNEDCMEGVPLLETSFPMRNNVILHDDYDVSAIDDQSPANLSGELRHHLNGLMYSLYQQSVIPSDPCFCQEEADRQHQLIFEDQCKDQRQSVQSDQGYISRCSPLPPDDPVEEEEEDQENQVVCHELSPEILNSLKSLQQQLFFQDIQQSSESGYPAELVNMSPSSEDC</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1991-11-01" modified="2025-02-05" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>P23410</accession>
    <name>MSX2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName>Homeobox protein MSX-2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>MSX-1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>QUOX-7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">MSX2</name>
        <name type="synonym">MSX1</name>
        <name type="synonym">QUOX-7</name>
    </gene>
    <organism>
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1990" name="Proc. Natl. Acad. Sci. U.S.A." volume="87" first="7482" last="7486">
            <title>cDNA cloning of a quail homeobox gene and its expression in neural crest-derived mesenchyme and lateral plate mesoderm.</title>
            <authorList>
                <person name="Takahashi Y."/>
                <person name="Le Douarin N."/>
            </authorList>
            <dbReference type="PubMed" id="1977161"/>
            <dbReference type="DOI" id="10.1073/pnas.87.19.7482"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a transcriptional regulator in bone development. Probable morphogenetic role. Binds to DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with MINT, with XRCC6 (Ku70) and XRCC5 (Ku80).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="tissue specificity">
        <text>Expressed in neural crest-derived mesenchyme and lateral plate mesoderm.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Msh homeobox family.</text>
    </comment>
    <dbReference type="EMBL" id="M57611">
        <property type="protein sequence ID" value="AAA63459.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="PIR" id="A38284">
        <property type="entry name" value="A38284"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P23410"/>
    <dbReference type="SMR" id="P23410"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048598">
        <property type="term" value="P:embryonic morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001503">
        <property type="term" value="P:ossification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000134">
        <property type="entry name" value="Homeobox protein MSX-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050674">
        <property type="entry name" value="Msh_Homeobox_Regulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24338">
        <property type="entry name" value="HOMEOBOX PROTEIN MSX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24338:SF10">
        <property type="entry name" value="HOMEOBOX PROTEIN MSX-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0217">Developmental protein</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0371">Homeobox</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0892">Osteogenesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000049103" description="Homeobox protein MSX-2">
        <location>
            <begin position="1"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="2">
        <location>
            <begin position="134"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="47"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="259" mass="28243" checksum="0CDF2512FDCC9A79" modified="1991-11-01" version="1">MASPSKAKEVFSSDEEGPAAGAEEHHKVKVSSLPFSVEALMSDKKPPKELPLAAAGSSADGATVGTSRNMLLPGHGSRDAHSPPGALTKTFDTASVKSENSEDGTSWIQEAGRYSPPPRHLSPTACTLRKHKTNRKPRTPFTTSQLLALERKFRQKQYLSIAERAEFSSSLNLTETQVKIWFQNRRAKAKRLQEAELEKLKMAANAMLPSGFSLPFPINSPIQAASLYGTSYPFHRPVLPIPPVGLYATPVGYSMYHLS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1994-02-01" modified="2025-02-05" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q05158</accession>
    <name>CSRP2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName>Cysteine and glycine-rich protein 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Cysteine-rich protein 2</fullName>
            <shortName>CRP2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">CSRP2</name>
    </gene>
    <organism>
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1993" name="Oncogene" volume="8" first="2317" last="2324">
            <title>Suppression in transformed avian fibroblasts of a gene (crp) encoding a cysteine-rich protein containing LIM domains.</title>
            <authorList>
                <person name="Weiskirchen R"/>
                <person name="Bister K"/>
            </authorList>
            <dbReference type="PubMed" id="8361751"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA]</scope>
        <source>
            <tissue>Embryonic fibroblast</tissue>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Biochemistry" volume="37" first="7127" last="7134">
            <title>Structure and intramodular dynamics of the amino-terminal LIM domain from quail cysteine- and glycine-rich protein CRP2.</title>
            <authorList>
                <person name="Kontaxis G."/>
                <person name="Konrat R."/>
                <person name="Kraeutler B."/>
                <person name="Weiskirchen R."/>
                <person name="Bister K."/>
            </authorList>
            <dbReference type="PubMed" id="9585524"/>
            <dbReference type="DOI" id="10.1021/bi973055v"/>
        </citation>
        <scope>STRUCTURE BY NMR OF 8-67</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1997" name="J. Biol. Chem." volume="272" first="12001" last="12007">
            <title>Solution structure of the carboxyl-terminal LIM domain from quail cysteine-rich protein CRP2.</title>
            <authorList>
                <person name="Konrat R."/>
                <person name="Weiskirchen R."/>
                <person name="Krautler B."/>
                <person name="Bister K."/>
            </authorList>
            <dbReference type="PubMed" id="9115265"/>
            <dbReference type="DOI" id="10.1074/jbc.272.18.12001"/>
        </citation>
        <scope>STRUCTURE BY NMR OF 117-175</scope>
    </reference>
    <comment type="function">
        <text>Interacts with zyxin. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression. Totally down-regulated in transformed cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="Z21643">
        <property type="protein sequence ID" value="CAA79759.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="PIR" id="S41761">
        <property type="entry name" value="S41761"/>
    </dbReference>
    <dbReference type="PDB" id="1A7I">
        <property type="method" value="NMR"/>
        <property type="chains" value="A=1-81"/>
    </dbReference>
    <dbReference type="PDB" id="1CXX">
        <property type="method" value="NMR"/>
        <property type="chains" value="A=82-194"/>
    </dbReference>
    <dbReference type="PDB" id="1IBI">
        <property type="method" value="NMR"/>
        <property type="chains" value="A=82-194"/>
    </dbReference>
    <dbReference type="PDB" id="1QLI">
        <property type="method" value="NMR"/>
        <property type="chains" value="A=82-194"/>
    </dbReference>
    <dbReference type="PDBsum" id="1A7I"/>
    <dbReference type="PDBsum" id="1CXX"/>
    <dbReference type="PDBsum" id="1IBI"/>
    <dbReference type="PDBsum" id="1QLI"/>
    <dbReference type="AlphaFoldDB" id="Q05158"/>
    <dbReference type="SMR" id="Q05158"/>
    <dbReference type="Ensembl" id="ENSCJPT00005027650.1">
        <property type="protein sequence ID" value="ENSCJPP00005020016.1"/>
        <property type="gene ID" value="ENSCJPG00005016171.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154980"/>
    <dbReference type="EvolutionaryTrace" id="Q05158"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042805">
        <property type="term" value="F:actinin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008307">
        <property type="term" value="F:structural constituent of muscle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CAFA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060537">
        <property type="term" value="P:muscle tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045214">
        <property type="term" value="P:sarcomere organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09480">
        <property type="entry name" value="LIM1_CRP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09840">
        <property type="entry name" value="LIM2_CRP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="DisProt" id="DP00438"/>
    <dbReference type="FunFam" id="2.10.110.10:FF:000001">
        <property type="entry name" value="Cysteine and glycine-rich protein 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24215:SF3">
        <property type="entry name" value="CYSTEINE AND GLYCINE-RICH PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24215">
        <property type="entry name" value="RHO-GTPASE-ACTIVATING PROTEIN LRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0217">Developmental protein</keyword>
    <keyword id="KW-0221">Differentiation</keyword>
    <keyword id="KW-0440">LIM domain</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="initiator methionine" description="Removed" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000075725" description="Cysteine and glycine-rich protein 2">
        <location>
            <begin position="2"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding 1" evidence="3">
        <location>
            <begin position="10"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding 2" evidence="3">
        <location>
            <begin position="120"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Nuclear localization signal" evidence="2">
        <location>
            <begin position="64"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="94"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="strand" evidence="5">
        <location>
            <begin position="11"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="strand" evidence="5">
        <location>
            <begin position="22"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="strand" evidence="5">
        <location>
            <begin position="28"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="strand" evidence="5">
        <location>
            <begin position="38"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="strand" evidence="5">
        <location>
            <begin position="50"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="strand" evidence="5">
        <location>
            <begin position="55"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="helix" evidence="5">
        <location>
            <begin position="60"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="strand" evidence="8">
        <location>
            <begin position="118"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="turn" evidence="6">
        <location>
            <begin position="121"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="strand" evidence="6">
        <location>
            <begin position="129"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="strand" evidence="6">
        <location>
            <begin position="133"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="strand" evidence="8">
        <location>
            <begin position="138"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="turn" evidence="6">
        <location>
            <begin position="142"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="strand" evidence="6">
        <location>
            <begin position="148"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="strand" evidence="7">
        <location>
            <begin position="159"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="strand" evidence="7">
        <location>
            <begin position="165"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="helix" evidence="6">
        <location>
            <begin position="169"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PDB" id="1A7I"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PDB" id="1CXX"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PDB" id="1IBI"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PDB" id="1QLI"/>
        </source>
    </evidence>
    <sequence length="194" mass="20911" checksum="D59CA624D1C1269E" modified="2007-01-23" version="2">MPNWGGGNKCGACGRTVYHAEEVQCDGRSFHRCCFLCMVCRKNLDSTTVAIHDAEVYCKSCYGKKYGPKGYGYGQGAGTLNMDRGERLGIKPESSPSPHRPTTNPNTSKFAQKFGGAEKCSRCGDSVYAAEKVIGAGKPWHKNCFRCAKCGKSLESTTLTEKEGEIYCKGCYAKNFGPKGFGYGQGAGALVHAQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-03-03" modified="2025-04-09" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q90370</accession>
    <name>MAFB_COTJA</name>
    <protein>
        <recommendedName>
            <fullName>Transcription factor MafB</fullName>
            <shortName>Maf-B</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">MAFB</name>
    </gene>
    <organism>
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1996" name="Cell" volume="85" first="49" last="60">
            <title>MafB is an interaction partner and repressor of Ets-1 that inhibits erythroid differentiation.</title>
            <authorList>
                <person name="Sieweke MHH"/>
                <person name="Tekotte H"/>
                <person name="Frampton J"/>
                <person name="Graf T"/>
            </authorList>
            <dbReference type="PubMed" id="8620536"/>
            <dbReference type="DOI" id="10.1016/S0092-8674(00)81081-8"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA]</scope>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH ETS1</scope>
        <scope>DNA-BINDING</scope>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Acts as a transcriptional activator or repressor. Plays a pivotal role in regulating lineage-specific hematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells. Binds DNA via its basic region-leucine zipper domain.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 4">Homodimer or heterodimer with other bHLH-Zip transcription factors. Binds DNA as a homodimer or a heterodimer (By similarity). Interacts with ETS1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="tissue specificity">
        <text evidence="4">Expressed in bursa, gut, liver, spleen, bone marrow and brain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the bZIP family. Maf subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="X96511">
        <property type="protein sequence ID" value="CAA65360.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q90370"/>
    <dbReference type="SMR" id="Q90370"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045637">
        <property type="term" value="P:regulation of myeloid cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14718">
        <property type="entry name" value="bZIP_Maf_large"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000016">
        <property type="entry name" value="MAF bZIP transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004826">
        <property type="entry name" value="bZIP_Maf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013592">
        <property type="entry name" value="Maf_TF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008917">
        <property type="entry name" value="TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024874">
        <property type="entry name" value="Transcription_factor_Maf_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10129">
        <property type="entry name" value="TRANSCRIPTION FACTOR MAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10129:SF10">
        <property type="entry name" value="TRANSCRIPTION FACTOR MAFB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03131">
        <property type="entry name" value="bZIP_Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08383">
        <property type="entry name" value="Maf_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47454">
        <property type="entry name" value="A DNA-binding domain in eukaryotic transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0010">Activator</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0678">Repressor</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000366124" description="Transcription factor MafB">
        <location>
            <begin position="1"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="bZIP" evidence="2">
        <location>
            <begin position="226"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="35"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="150"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Basic motif" evidence="2">
        <location>
            <begin position="226"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Leucine-zipper" evidence="2">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="157"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="8620536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="311" mass="35476" checksum="7D1F3FA05D5CD683" modified="1996-11-01" version="1">MAGELSIGAELPTSPLAMEYVNDFDLMKFDVKKEPLGRNDRSGRHCTRLQPAGSVSSTPISTPCSSVPSSPSFSPTEQKTHLEDLYWMANSYQQMNPEALNLTPEDAVEALIGSHQVSQQLQGFESFRAHHHHHHHHQHHHHQYPAVTHEDLAGSGHPHHHHHHHHHASPTPSTSSSSSQQLQTSHQQHPPSSSVEDRFSDDQLVSMSVRELNRHLRGFTKDEVIRLKQKRRTLKNRGYAQSCRYKRVQQKHHLENEKTQLIQQVEQLKQEVTRLARERDAYKLKCEKLASNGFREAGSTSDNPSSPEFFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SLW3</accession>
    <name>A0A8C2SLW3_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein phosphatase 1 regulatory subunit 14D</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PP1 inhibitor family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SLW3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005000416.1">
        <property type="protein sequence ID" value="ENSCJPP00005000209.1"/>
        <property type="gene ID" value="ENSCJPG00005000284.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000172514"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004865">
        <property type="term" value="F:protein serine/threonine phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.220">
        <property type="entry name" value="CPI-17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008025">
        <property type="entry name" value="CPI-17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036658">
        <property type="entry name" value="CPI-17_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16188">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 INHIBITOR POTENTIATED BY PROTEIN KINASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16188:SF5">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 14B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05361">
        <property type="entry name" value="PP1_inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81790">
        <property type="entry name" value="Myosin phosphatase inhibitor 17kDa protein, CPI-17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="3" id="KW-0650">Protein phosphatase inhibitor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="84"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="108"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005000209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="171" mass="19196" checksum="FF3A1C0F19CD3212" modified="2022-01-19" version="1">MAAPPPAGPGPNSTPGPRVCFAPEPEGTDNGSIGPEEGTGNRRGGKVTVRYDRRELRKRLHLEEWILAQLTALYDCRTPKSPLFTPKLTPNPPFSPQKETPKPPFFTQKMTQNPPFSTQKLIPKPHFSPHRAPKSPFFTPKRDPKIPTFHPKKSPRIPLFHPKNEPQNSPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SMV2</accession>
    <name>A0A8C2SMV2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">PSMA2</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="5">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015710408.1">
        <property type="nucleotide sequence ID" value="XM_015854922.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SMV2"/>
    <dbReference type="SMR" id="A0A8C2SMV2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005000443.1">
        <property type="protein sequence ID" value="ENSCJPP00005000222.1"/>
        <property type="gene ID" value="ENSCJPG00005000303.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107309823"/>
    <dbReference type="KEGG" id="cjo:107309823"/>
    <dbReference type="CTD" id="5683"/>
    <dbReference type="GeneTree" id="ENSGT00550000074870"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009615">
        <property type="term" value="P:response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03750">
        <property type="entry name" value="proteasome_alpha_type_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000012">
        <property type="entry name" value="Proteasome subunit alpha type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="6">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005000222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="234" mass="25920" checksum="3909BAE459E8695D" modified="2022-01-19" version="1">MAERGYSFSLTTFSPSGKLVQIEYALAAVAAGAPSVGIKAANGVVLATEKKQKSILYDERSVHKVEPITKHIGLVYSGMGPDYRVLVHRARKLAQQYFLVYHEPIPTAQLVQRIASVMQEYTQSGGVRPFGVSLLICGWNEGRPYLFQSDPSGAYFAWKATAMGKNYVNGKTFLEKRYNEDLELEDAIHTAILTLKESFEGQMTEDNIEVGICNEAGFRRLTPTEVKDYLAAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SPT6</accession>
    <name>A0A8C2SPT6_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SPT6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005003546.1">
        <property type="protein sequence ID" value="ENSCJPP00005001997.1"/>
        <property type="gene ID" value="ENSCJPG00005002133.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="Compl_asym_regulator"/>
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    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
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    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
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    <dbReference type="PANTHER" id="PTHR22906">
        <property type="entry name" value="PROPERDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906:SF43">
        <property type="entry name" value="PROPERDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01705">
        <property type="entry name" value="TSP1REPEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="3"/>
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        <property type="entry name" value="TSP-1 type 1 repeat"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005001997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="321" mass="34434" checksum="72041F1F39550A20" modified="2022-01-19" version="1">MGSMGRSMGSMGRSMGLYGVYGSIYGSLWGLWVDLWVSMGSMGLYGSLWGVWVDLWVSMGSMGLYGVYGSKWGWLEAGEGERAGRVVIGREAGGGRGFQLTPPPFLPPPNPEVGGAWGEWSQWGPCGVTCRGKGSTSVRSRKRKCDNPAPSVEPPGSPCPGEGTEVGECPGLGAGLKRGRGLKSGRNLLMAEPKLPTCVSGLRGNFRPWAELTPCHVTCGLGVVTWKRSCDAPPPQHGGRGCHGNTVPHWGPWSPWTHCERRPWGELRCKEAVGQQKRTRECVGWKEGGSPCPISGGLGTIQLRACYNVHHCLRECPISAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SRU9</accession>
    <name>A0A8C2SRU9_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Zinc finger MYND-type containing 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">ZMYND8</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015737034.1">
        <property type="nucleotide sequence ID" value="XM_015881548.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015737035.1">
        <property type="nucleotide sequence ID" value="XM_015881549.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SRU9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005001929.1">
        <property type="protein sequence ID" value="ENSCJPP00005001119.1"/>
        <property type="gene ID" value="ENSCJPG00005001181.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107322957"/>
    <dbReference type="KEGG" id="cjo:107322957"/>
    <dbReference type="CTD" id="23613"/>
    <dbReference type="GeneTree" id="ENSGT00940000154897"/>
    <dbReference type="OrthoDB" id="6272564at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090734">
        <property type="term" value="C:site of DNA damage"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0140015">
        <property type="term" value="F:histone H3K14ac reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140109">
        <property type="term" value="F:histone H3K4me1 reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030336">
        <property type="term" value="P:negative regulation of cell migration"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071168">
        <property type="term" value="P:protein localization to chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="Bromo_RACK7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15538">
        <property type="entry name" value="PHD_PRKCBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20160">
        <property type="entry name" value="PWWP_PRKCBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000003">
        <property type="entry name" value="Protein kinase C-binding protein 1 isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.140.2220:FF:000002">
        <property type="entry name" value="Protein kinase C-binding protein 1 isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000005">
        <property type="entry name" value="protein kinase C-binding protein 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057053">
        <property type="entry name" value="MYND_ZMYND11_ZMYD8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044075">
        <property type="entry name" value="PRKCBP1_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021931">
        <property type="entry name" value="ZMYND8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037967">
        <property type="entry name" value="ZMYND8_Bromo_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056987">
        <property type="entry name" value="ZMYND8_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46453:SF3">
        <property type="entry name" value="MYND-TYPE ZINC FINGER-CONTAINING CHROMATIN READER ZMYND8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46453">
        <property type="entry name" value="PROTEIN KINASE C-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12064">
        <property type="entry name" value="DUF3544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24324">
        <property type="entry name" value="MYND_ZMYND11_ZMYD8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23460">
        <property type="entry name" value="ZMYND8_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00293">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 12" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="7" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="17">
        <location>
            <begin position="115"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="16">
        <location>
            <begin position="192"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="PWWP" evidence="18">
        <location>
            <begin position="304"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="19">
        <location>
            <begin position="1051"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="437"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="609"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1094"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="998"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="460"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="499"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="523"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="612"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="632"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="668"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="743"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="772"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="795"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="840"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="860"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1094"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1108"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1126"/>
            <end position="1138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005001119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1176" mass="131322" checksum="0DE1193BEFEE5732" modified="2022-01-19" version="1">MHPQSLAEEEIKAEQEVVEGMDISTRSKGLFVSDVDPGSAERTAQKRKFPSPPHSSNGHSPQDASTSPIKKKKKPGLLNSNNKEQSELRHGPFYYMKQPLTTDPVDVVPQDGRNDFYCWVCHREGQVLCCELCPRVYHAKCLKLTAEPEGDWFCPECEKITVAECIETQSKAMTMLTTEQLSYLLKFALQKMKQPGTEPFQKPVSLDQHPDYAEYIFHPMDLCTLEKNVKKKMYGCTEAFLADAKWILHNCIIYNGGNHKLTQTAKVIIKICEHEMNEIEVCPECYLAACQKRENWFCEPCSNPHPLVWAKLKGFPFWPAKALRDKDGQVDARFFGQHDRAWVPINNCYLMSKEIPFSVKKTKSIFNSAMQEMEVYVDNIRRRFGVFNYAPFRTPYTPNNQYQMLLDPTNPTAGTAKTDKQEKIKLNFDMTASPKILMSKPMLSSSTGRRISLTDMPRSPMSTNSSVHTGSDVEQDAEKKATSSHFSASEESMDFIEKNTASPAPTRTGQAGSLSGSPKPFSPQASTPISAKQERTATPGSILNLNLDRSKAEMDLKELSESVQQQSTPVPLISPKRQIRSRFQLNLDKTIESCKAQLGINEISEAVYTAVEHSDSEDSEKSDTSDSEYSDEDQKSKNDQEDGEDKEGTRSDKESLSLKKKLKPPAQNEDKEELKSTSPEVEKTDDPVKEKAITDTDKEFSEKGKSLQHPAKEKLKGKDETDSPTVHLGLDSDSESELVIDLGDDHCGREGRKNKKESKEPPPKQDVVGKTPPSSSASTQPLPETPVLTRSASQTPPAGVTATTSATSTVSAPSAATGSPVKKQRPLLPKETAPAVQRVVWNSSNKFQTSSQKWHMQKVQRQQQQQQNQQSQSQQPQSSQGTRYQTRQAVKAVQQKEITQSTSTSTITLVTSTQPISMVTSSGSASTLSSSLNTDLPIATASADVAADIAKYTSKMMDAIKGTMTEIYNDLSKNTTGSTIAEIRRLRIEIEKLQWLHQQELSEMKHNLELTMAEMRQSLEQERDRLIAEVKKQLEMEKQQAVDETKKKQWCANCKKEAIFYCCWNTSYCDYPCQQAHWPEHMKSCTQSATATQQETDTEINTETLNKSSQPSSSAQPTPTETASTPKEKDISTDKSKESVTIATGVTSNQPIKLVQVPQTTTYIPTTQHTIVIPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SS10</accession>
    <name>A0A8C2SS10_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cone-rod homeobox</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">CRX</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SS10"/>
    <dbReference type="Ensembl" id="ENSCJPT00005005356.1">
        <property type="protein sequence ID" value="ENSCJPP00005002933.1"/>
        <property type="gene ID" value="ENSCJPG00005003206.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161634"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043522">
        <property type="term" value="F:leucine zipper domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016922">
        <property type="term" value="F:nuclear receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060041">
        <property type="term" value="P:retina development in camera-type eye"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45793:SF22">
        <property type="entry name" value="CONE-ROD HOMEOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45793">
        <property type="entry name" value="HOMEOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0371">Homeobox</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="100"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005002933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="302" mass="31325" checksum="05E6FB6AAA7640F7" modified="2022-01-19" version="1">MMSYIKQPHYAVNGLTLAGPGMDLLHSAVGYPAPRQHDVKRQLTFTSEARAGHLLEALFFANREVALNRFNLPLLTSVISPLPPPQVWFKNAAAKLPAACQGRASGSPRPAAKKKPTPPRNPKAHAGGPVHTSPTPARSGTGPPVPCSSLLLGSHGFHLSGTGSVGAPQRSGFATFAPFVWLQPYNQTAPYGQSYGGSAAYFGGAGLAGPTCPPCTPHWGLPAAALSPLGAPMGCSPDSPSPAAFIGEFWWPGWGLGLGRGKLNFNAADCLDYKEQSSWKFQCCEGGGIGGIWGGRGGFGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2ST51</accession>
    <name>A0A8C2ST51_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2ST51"/>
    <dbReference type="Ensembl" id="ENSCJPT00005004577.1">
        <property type="protein sequence ID" value="ENSCJPP00005002491.1"/>
        <property type="gene ID" value="ENSCJPG00005002750.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01140000282784"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005002491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="104" mass="11654" checksum="78A53AAC0865AE2C" modified="2022-01-19" version="1">MASLQVETEKLTIVGMKFSLMMMERICFQSVVLSPRSRQMDSSASFTAAGGLAIERTSTRCCFFMDFTANQYQNDDRLDHLWTRTRPSSLLSLCTGSSALENVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SV87</accession>
    <name>A0A8C2SV87_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein bL19m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">39S ribosomal protein L19, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MRPL19</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bL19 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SV87"/>
    <dbReference type="Ensembl" id="ENSCJPT00005004740.1">
        <property type="protein sequence ID" value="ENSCJPP00005002560.1"/>
        <property type="gene ID" value="ENSCJPG00005002842.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000009415"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.790:FF:000002">
        <property type="entry name" value="39S ribosomal protein L19, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001857">
        <property type="entry name" value="Ribosomal_bL19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038657">
        <property type="entry name" value="Ribosomal_bL19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680:SF9">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL19M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680">
        <property type="entry name" value="RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01245">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005002560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="404" mass="46068" checksum="01E34D4A681329B5" modified="2022-01-19" version="1">MPMCGSISESITGLPGLSQNCRGWKGPLEISESNPLPKQVPYTTSHISASRRVLNISRGDSPTPPVQPVPALIMNRAREGAGSRTAHSFALGVVLTLRSCRSRCGVGGPEVVVAAMAAACGRALLRGARPALHPRWFSSSTCRTSSDGQRAKFQPPPKPVIIDRQKRREERRFLSPEFIPPRGRTDPLKFYMERKDMIQRRKVFNIPEFYVGSILAVTTADPYADGKTNRFVGICIQRGGKGLGATFVLRNVIEDQGIEICYELYSPRIQEITVLKLEKRLDDNLMYLRDALPEYSTFDVNMKPVPHLDHEEIPVNKLQVRMKPKPWSKRWERPKYNIKGIKFELPEKKMKEAEKWKQPWLEFDMLREYDTSKIEEKIWRERKARSNLKVYTCTKTTSPARNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SVR3</accession>
    <name>A0A8C2SVR3_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mucin-3B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC107307211</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SVR3"/>
    <dbReference type="SMR" id="A0A8C2SVR3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005006587.1">
        <property type="protein sequence ID" value="ENSCJPP00005003774.1"/>
        <property type="gene ID" value="ENSCJPG00005003895.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01140000282779"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.960">
        <property type="entry name" value="SEA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053311">
        <property type="entry name" value="Mucosal_Integrity_Assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000082">
        <property type="entry name" value="SEA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036364">
        <property type="entry name" value="SEA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37999">
        <property type="entry name" value="MUCIN-17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37999:SF2">
        <property type="entry name" value="MUCIN-17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01390">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00200">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82671">
        <property type="entry name" value="SEA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50024">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="SEA" evidence="3">
        <location>
            <begin position="26"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005003774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="313" mass="33776" checksum="3D8CD00ACEFFE72D" modified="2022-01-19" version="1">MGSLWGPYGVSYGVGVHLWVCPIATVSASVRMSAQVVNRNFSPELENPKSPQYIQFSIDFQDKMKELYRNVSGYEGVEILSLREGSVVVTYDVLLRVEAGNSAPSALEDRLEDLRKATATNCSGVTSELCFNGSYTTVSNYSIQPLDPALCNALVPPSLIGWYSPIPAPSGVLCVSRCHPQSERPFPCTHGACAVSSDGPHCDCSDRSSYWYLDSSCSSRVNKWGLALGLPLAAICVIATGCGAALVKARRQRRADRAGGARRDLHQPTECGARQGPPPTASILRPPLKIDPKTAPKRPQIRPPPPPNDPINQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SWF2</accession>
    <name>A0A8C2SWF2_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sarcospan</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">SSPN</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015724491.1">
        <property type="nucleotide sequence ID" value="XM_015869005.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SWF2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005005489.1">
        <property type="protein sequence ID" value="ENSCJPP00005003040.1"/>
        <property type="gene ID" value="ENSCJPG00005003282.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107316934"/>
    <dbReference type="KEGG" id="cjo:107316934"/>
    <dbReference type="CTD" id="8082"/>
    <dbReference type="GeneTree" id="ENSGT00390000007747"/>
    <dbReference type="OrthoDB" id="10027693at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016010">
        <property type="term" value="C:dystrophin-associated glycoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030133">
        <property type="term" value="C:transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007237">
        <property type="entry name" value="CD20-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030429">
        <property type="entry name" value="Sarcospan"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15260">
        <property type="entry name" value="SARCOSPAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15260:SF1">
        <property type="entry name" value="SARCOSPAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04103">
        <property type="entry name" value="CD20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005003040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="249" mass="27581" checksum="EDC4F616E99748D3" modified="2022-01-19" version="1">MGKKEKKAQHNAAHSGEQGTDSGHTQEPAMKKKKKKKSKGEAKAGRDKESHTCCWCRFPLLCALLQLAFGVAVTVLGFLMAGISSSLPVRDTPYWAGIIVCVVSLVGFVMLCISYQPDEKTCVQFTVKLMYFLLSALALVLCVVAAAFAAHHYLQMTKFTCDTILESCQCKLDTADPLSRTFVYQDAADCSSVTSMLGLYLILQMVLNLLAALVCLLACFVMWKHRYQVFYVGARFYPLTTTECQQQKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SX14</accession>
    <name>A0A8C2SX14_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mothers against decapentaplegic homolog</fullName>
            <shortName evidence="7">MAD homolog</shortName>
            <shortName evidence="7">Mothers against DPP homolog</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">SMAD family member</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">SMAD7</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the dwarfin/SMAD family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015742708.1">
        <property type="nucleotide sequence ID" value="XM_015887222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SX14"/>
    <dbReference type="Ensembl" id="ENSCJPT00005008343.1">
        <property type="protein sequence ID" value="ENSCJPP00005005091.1"/>
        <property type="gene ID" value="ENSCJPG00005004928.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107325931"/>
    <dbReference type="KEGG" id="cjo:107325931"/>
    <dbReference type="CTD" id="4092"/>
    <dbReference type="GeneTree" id="ENSGT00940000159872"/>
    <dbReference type="OrthoDB" id="5946219at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome Z"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001650">
        <property type="term" value="C:fibrillar center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071144">
        <property type="term" value="C:heteromeric SMAD protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070697">
        <property type="term" value="F:activin receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="term" value="F:beta-catenin binding"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:collagen binding"/>
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        <property type="term" value="F:I-SMAD binding"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:type I transforming growth factor beta receptor binding"/>
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        <property type="term" value="F:ubiquitin-like ligase-substrate adaptor activity"/>
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        <property type="term" value="P:artery morphogenesis"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:ventricular septum morphogenesis"/>
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        <property type="entry name" value="MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 7"/>
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    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MH1" evidence="9">
        <location>
            <begin position="8"/>
            <end position="169"/>
        </location>
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        <location>
            <begin position="223"/>
            <end position="388"/>
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            <begin position="18"/>
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    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
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        </source>
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    <sequence length="388" mass="42961" checksum="80D201602FCE5410" modified="2022-01-19" version="1">MFRTKRSLLVRRLWRSRAPGGGEEETGDGAAPAEPRPHSCGGGNRGCCPAKPPRGGGRGAAEGELKALTHAVLKRCKERQLEGLLRAVESRGAARTPCVLLPARGEARLGAQRDALPALLCRVFRWPELRHGAPLKRLRGCCQADGAAPTELVCCNPHHLSRLCELESPPPPYSRYPMDFLKPTAGCPDSVPSSTETGGTNCLAPGGLSDSQVLQESGDHSHWCVVAYWEEKTRVGRLYSVQEPSLDIFYDLPQGNGFCLGQLNSDNRSQLVQKVRSKIGYGIQLTKEVDGVWVYNRSSYPIFIKSATLDNPDSRTLLVHKVFPGFSIKAFDYEKAYSLQRPNDHEFTQQPWTGFTVQISFVKGWGQCYTRQFISSCPCWLEVIFNNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SXD0</accession>
    <name>A0A8C2SXD0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">FYVE and coiled-coil domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">FYCO1</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">May mediate microtubule plus end-directed vesicle transport.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasmic vesicle</location>
            <location evidence="3">Autophagosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lysosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015709568.1">
        <property type="nucleotide sequence ID" value="XM_015854082.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015709569.1">
        <property type="nucleotide sequence ID" value="XM_015854083.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015709570.1">
        <property type="nucleotide sequence ID" value="XM_015854084.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015709571.1">
        <property type="nucleotide sequence ID" value="XM_015854085.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015709572.1">
        <property type="nucleotide sequence ID" value="XM_015854086.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005007307.1">
        <property type="protein sequence ID" value="ENSCJPP00005004366.1"/>
        <property type="gene ID" value="ENSCJPG00005004324.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107309363"/>
    <dbReference type="KEGG" id="cjo:107309363"/>
    <dbReference type="CTD" id="79443"/>
    <dbReference type="GeneTree" id="ENSGT00940000154044"/>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072383">
        <property type="term" value="P:plus-end-directed vesicle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901098">
        <property type="term" value="P:positive regulation of autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd15726">
        <property type="entry name" value="FYVE_FYCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17698">
        <property type="entry name" value="RUN_FYCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.900:FF:000010">
        <property type="entry name" value="FYVE and coiled-coil domain containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.680:FF:000004">
        <property type="entry name" value="FYVE and coiled-coil domain containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000341">
        <property type="entry name" value="FYVE and coiled-coil domain containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.680">
        <property type="entry name" value="GOLD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047337">
        <property type="entry name" value="FYVE_FYCO1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004012">
        <property type="entry name" value="Run_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037213">
        <property type="entry name" value="Run_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047336">
        <property type="entry name" value="RUN_FYCO1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46753:SF4">
        <property type="entry name" value="FYVE AND COILED-COIL DOMAIN AUTOPHAGY ADAPTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46753">
        <property type="entry name" value="FYVE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02759">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140741">
        <property type="entry name" value="RUN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50826">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10 16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-0458">Lysosome</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RUN" evidence="19">
        <location>
            <begin position="36"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="18">
        <location>
            <begin position="1242"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="20">
        <location>
            <begin position="1431"/>
            <end position="1546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1102"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1306"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="233"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="823"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1102"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1308"/>
            <end position="1318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00055152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00073225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005004366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1558" mass="179355" checksum="201C717538826E5C" modified="2022-01-19" version="1">MEAATGESQLQRIIRDLQDAVAELSKEFKEGGEPITDDSVNLQKFSYKLEYLLQFDQKEKSTLLGNRKDYWDYFCDCLAKVKGANDGIRFVKSITELRTSLGKGRAFLRYSLVHQRLADTLQQCFMNTKVTSDWYYARSPFLNPKMSSDIVGHLYELTDVQFDLASRGYDLDAAWPAFARRTLSSLGSSAYLWKPPSRSSSMSSLVSNYLQAPEFPSSPDANNSLNAEHFEGFEEMRVELDQAELRQKELQRSIHQLEMENQELQAAVSLHKEQLRLEKEKSNNYSEENSRLTKMITELQKQCEVSQSTQSTVHDLQKCLQSLELNAVEQQKEYSTKLAQLTTSKEDYASKLQLLNEELEVSRALVAMKELCIDELKAKLSSAEQKNLNLLAKVDAALEEKGQKATAQCDSALQIQALLEKLQQTEKEKAEMQRLSDERTSQLKTAKEQLQLKEESQKELESRFNHLAAYSREENENLLRSLETMEKEMDALQKALTLKEKEMTELQTQVMGSLAQVGSLEKDLEEARKEKEKLKEEYGKMEEALKEEAQSQAEKFEQQEGHLKKVSETVCSLEEQNQKLFYEKEHLSQKVKELEEQMEQQNSAVNEMSEESRKLKTENADLQQFKKKMEEKLKNLEASKDSLEAEVAKLRASEKQLQSEIDDALVSVDEKEKKLRSQNKQLDEDLQNARRQSQILEEKLEALRSEYRELKEREETMKESCDSLEGQLKSAKQHSLQIEKSLDTLKESKESLQSQLAEKEVQLQGMESQCEQLRAEAERHRKKTETLEVEKLSAENTCLQQTRLIESLTSEKESMEKHQLQQAASLEKDAKDLASRLTVSEEQLQVNQDEVSRLQTEVLDLRVKLQQTSDEREQLKSDLAITASFLGEQKELVQQLKEQTESLNRNHVQELVQCKEREEVLKREQETAVLQKTELENNLLSLKEELSKVKQYLDAARMENVENKDLLHKTNTDMAELGIQICALSSEKVDAEEQLTQAKERLKELEEQAAAQQEELKHDISYLRQENRSLQEKLEEAQICVSALPSLQAQLETAKKQAQSLQETSQEELSAIKFQMSTEILNYQTKFKTTSEECGKLREQLEEQKRQQRATEEEIAGLQAENTSLSRKLDEAREQLSELQSARLQKEEEVASLRELLERTQKEADEAKKQALDYSEKLSKVAADKDSNDQKLFAELDDLTRTKQFLEERLIELIRDKDALWQKSDALEFQQKLSAEQKWQGDTEVNHCLDCQREFSWMVRRHHCRMCGRIFCYYCCNNYMVTKPGGRKERCCKACFNKPRVIVDNTDDSGSSANQEGSPGSLESPVSPDEASKPPDDAAFDIITDEELCQVQESDSLHSESQMDRDSLDQSVTDLPVTHSWWYSRVYPVHLPFLRNSTCNSSAFDESEEWQVAQDAEISLLKSGEIMVRLPLTVEEIVNFGEGNRELFIKSSTYSIIPITVTEIGLTISWIFSSDPKSISFSVVYQESEDTPLDQCRVLIPMTRCNSHKETIRGQMKVRNPGIYTLIFDNTFSRFISKRVFYQLTVERPVIYDGSDFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SY99</accession>
    <name>A0A8C2SY99_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SY99"/>
    <dbReference type="Ensembl" id="ENSCJPT00005007907.1">
        <property type="protein sequence ID" value="ENSCJPP00005004798.1"/>
        <property type="gene ID" value="ENSCJPG00005004662.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01040000244754"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005004798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="79" mass="9014" checksum="1BBC6F46F7896CEC" modified="2022-01-19" version="1">FFLISPYFYVLYLHLKMRRNVFLNSERICSIQLGTLALCGAKWVPLSCRIASVLSSYCLVATGLMLADYNSVASHFRFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SYT5</accession>
    <name>A0A8C2SYT5_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Translation initiation factor eIF2 assembly protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Cell division cycle protein 123 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">CDC123</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">ATP-dependent protein-folding chaperone for the eIF2 complex. Binds to the gamma subunit of the eIF2 complex which allows the subunit to assemble with the alpha and beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDC123 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SYT5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005007576.1">
        <property type="protein sequence ID" value="ENSCJPP00005004539.1"/>
        <property type="gene ID" value="ENSCJPG00005004475.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000003057"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905143">
        <property type="term" value="P:eukaryotic translation initiation factor 2 complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009772">
        <property type="entry name" value="CDC123"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15323:SF6">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 123 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15323">
        <property type="entry name" value="D123 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07065">
        <property type="entry name" value="D123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007807">
        <property type="entry name" value="Cdc123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00044080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00045515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005004539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="313" mass="36487" checksum="44A7FFEE8F785148" modified="2022-01-19" version="1">MKKEQVVHCQFSVWYPLFRAVTIRSVILPLPENVKEYLLDDGTLVWSDDENTATLKAPEFPEFTDKVEEAISSLGGSVFPKLNWSAPRDAYWIAMNSSLKCKALSDIFLLFKSSDFITRDLTQPFIHCTDDSPDPSLNYELVLRKWCELIPGAEFRCFVKENKLIGISQRDYTQYYDHISKQHEEICRSVQEFFKKHIQYKFLDEDFVFDVYRDSRGKIWLIDFNPFGEVTDSLLFTWDELTSGRNLKGDQSEGEATEQDCPVFRCTNSQVTVQPSPYLSYRLPKDFVDLSTGEDVHKLIDFLKLKRNQQDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SYW4</accession>
    <name>A0A8C2SYW4_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">NADPH oxidase 4</fullName>
            <ecNumber evidence="6">1.6.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="primary">NOX4</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="22">NADPH oxidase that catalyzes predominantly the reduction of oxygen to H2O2. Can also catalyze to a smaller extent, the reduction of oxygen to superoxide. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB. May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation. Promotes ferroptosis, reactive oxygen species production and reduced glutathione (GSH) levels by activating NLRP3 inflammasome activation and cytokine release.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>NADPH + 2 O2 = 2 superoxide + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63180"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>NADPH + O2 + H(+) = H2O2 + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:11260"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.6.3.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Focal adhesion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.6.3.1" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2SYW4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005006939.1">
        <property type="protein sequence ID" value="ENSCJPP00005004060.1"/>
        <property type="gene ID" value="ENSCJPG00005004115.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159621"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043020">
        <property type="term" value="C:NADPH oxidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072341">
        <property type="term" value="F:modified amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016174">
        <property type="term" value="F:NAD(P)H oxidase H2O2-forming activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990782">
        <property type="term" value="F:protein tyrosine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016175">
        <property type="term" value="F:superoxide-generating NAD(P)H oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045453">
        <property type="term" value="P:bone resorption"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055007">
        <property type="term" value="P:cardiac muscle cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071333">
        <property type="term" value="P:cellular response to glucose stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003015">
        <property type="term" value="P:heart process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050667">
        <property type="term" value="P:homocysteine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000573">
        <property type="term" value="P:positive regulation of DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070374">
        <property type="term" value="P:positive regulation of ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051897">
        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042554">
        <property type="term" value="P:superoxide anion generation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000183">
        <property type="entry name" value="NADPH oxidase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000015">
        <property type="entry name" value="NADPH oxidase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000778">
        <property type="entry name" value="Cyt_b245_heavy_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050369">
        <property type="entry name" value="RBOH/FRE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972">
        <property type="entry name" value="NADPH OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972:SF206">
        <property type="entry name" value="NADPH OXIDASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00466">
        <property type="entry name" value="GP91PHOX"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0965">Cell junction</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0521">NADP</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 24" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="25">
        <location>
            <begin position="308"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="571"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00067129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00093404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005004060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="593" mass="68408" checksum="EE3D18D46EE19685" modified="2022-01-19" version="1">MAVSWRSWLANEGSKHLFLFFWLSLNAWFFWKTFLLYCRGLQYYYLHQMLGLGLCVSRASASVLNLNCCLVLLPMCRILLAFLRGSQKVASRKTRRLIDKSKTFHVTCGATICIFSVLHVAAHLVNALNFSENYNEDFLAINAAHYRGEDPRKLLFATVPGLTGVIMVLVLFLMCTASTYAIRVSNYDIFWYTHNLFFVFYILLMLHVSGGVLKYQTNLEEHPPGCFNPNKTLLGNMTEPKSFEELFPDYTTEPFPEDLTFPEPLVQSNFMRICSKEPKFQSHFPETWFWISGPLCLYCVERLYRYIRSTKPVTVTSVISHPSNVLEVRMIKDDFRARPGQYVILHCPRVSGLESHPFTLTMCPTDSKATFGVHLKVVGDWTERFRDLLLLHSNQDAEILPIFQQRRYPKLYVDGPFGSPFEESLNYEVSLCVAGGIGVTPFASVLNALLDGWKCYKLRRLYFIWVCRDIESFRWFADLLCMLHSKLWQENRPDYINIQLYLSQTDGIQKIIGEKYQALNSRLLIGRPRWKLLFDEIAKYNRRKTIGVFCCGPSKMSKALHKLSNSSNPYGTRMLKEHSSTGTSAHYSEAIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SZN8</accession>
    <name>A0A8C2SZN8_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">2-oxoisovalerate dehydrogenase subunit beta, mitochondrial</fullName>
            <ecNumber evidence="3">1.2.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Branched-chain alpha-keto acid dehydrogenase E1 component beta chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">BCKDHB</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Together with BCKDHA forms the heterotetrameric E1 subunit of the mitochondrial branched-chain alpha-ketoacid dehydrogenase (BCKD) complex. The BCKD complex catalyzes the multi-step oxidative decarboxylation of alpha-ketoacids derived from the branched-chain amino-acids valine, leucine and isoleucine producing CO2 and acyl-CoA which is subsequently utilized to produce energy. The E1 subunit catalyzes the first step with the decarboxylation of the alpha-ketoacid forming an enzyme-product intermediate. A reductive acylation mediated by the lipoylamide cofactor of E2 extracts the acyl group from the E1 active site for the next step of the reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 3-methyl-2-oxobutanoate + H(+) = N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:13457"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10497"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83142"/>
            <dbReference type="EC" id="1.2.4.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:13458"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterotetramer of 2 alpha/BCKDHA and 2 beta chains/BCKDHB that forms the branched-chain alpha-keto acid decarboxylase (E1) component of the BCKD complex. The branched-chain alpha-ketoacid dehydrogenase is a large complex composed of three major building blocks E1, E2 and E3. It is organized around E2, a 24-meric cubic core composed of DBT, to which are associated 6 to 12 copies of E1, and approximately 6 copies of the dehydrogenase E3, a DLD dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.2.4.4" evidence="3"/>
    <dbReference type="RefSeq" id="XP_032299225.1">
        <property type="nucleotide sequence ID" value="XM_032443334.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032299226.1">
        <property type="nucleotide sequence ID" value="XM_032443335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SZN8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005007407.1">
        <property type="protein sequence ID" value="ENSCJPP00005004423.1"/>
        <property type="gene ID" value="ENSCJPG00005004386.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005007408.1">
        <property type="protein sequence ID" value="ENSCJPP00005004425.1"/>
        <property type="gene ID" value="ENSCJPG00005004386.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107312019"/>
    <dbReference type="KEGG" id="cjo:107312019"/>
    <dbReference type="CTD" id="594"/>
    <dbReference type="GeneTree" id="ENSGT00940000156533"/>
    <dbReference type="OrthoDB" id="878at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160157">
        <property type="term" value="C:branched-chain alpha-ketoacid dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003863">
        <property type="term" value="F:branched-chain 2-oxo acid dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120552">
        <property type="term" value="P:branched-chain alpha-keto acid decarboxylation to branched-chain acyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007584">
        <property type="term" value="P:response to nutrient"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07036">
        <property type="entry name" value="TPP_PYR_E1-PDHc-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000004">
        <property type="entry name" value="2-oxoisovalerate dehydrogenase subunit beta 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42980:SF1">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42980">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="12">
        <location>
            <begin position="57"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00057409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00063295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00071568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005004423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="378" mass="41476" checksum="645244E276C7314A" modified="2022-01-19" version="1">MAAGLARVLRRYGGRTRCCGALRSRTAPLPAEPRRAAAHFAFEPDPAPSTYGQTQKMNLFQSITSALDNALAKDPTAVIFGEDVAFGGVFRCTVGLRDKYGKDRVFNTPLCEQGIVGFGIGVAVAGATAIAEIQFADYIFPAFDQIVNEAAKYRYRSGDLFNCGNLTIRAPWGCVGHGALYHSQSPEAFFAHCPGIKIVIPRSPLQAKGLLLSCIEDKNPCIFFEPKILYRAAVEQVPVEPYNIPLSQAEVLRQGSDVTLVAWGTQVHVIKEVAVMAQEKLGVSCEVIDLRTILPWDTETVCKSVAKTGRLLISHEAPLTGGFASEISSTVQEECFLNLEAPISRVCGYDTPFPHIFEPFYIPDKWKCYDALRKMINY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SZW1</accession>
    <name>A0A8C2SZW1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="44">Amyloid-beta A4 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="51" type="primary">APP</name>
    </gene>
    <organism evidence="51 52">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="51" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="51" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="51" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="44">Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 44">Cell membrane</location>
            <topology evidence="3 44">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cell projection</location>
            <location evidence="10">Growth cone</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cytoplasmic vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Early endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Membrane</location>
            <location evidence="8">Clathrin-coated pit</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Perikaryon</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11 43 44">Belongs to the APP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="43">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015736315.1">
        <property type="nucleotide sequence ID" value="XM_015880829.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SZW1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005007961.1">
        <property type="protein sequence ID" value="ENSCJPP00005004836.1"/>
        <property type="gene ID" value="ENSCJPG00005004694.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107322621"/>
    <dbReference type="KEGG" id="cjo:107322621"/>
    <dbReference type="CTD" id="351"/>
    <dbReference type="GeneTree" id="ENSGT00530000063252"/>
    <dbReference type="OrthoDB" id="9112501at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106003">
        <property type="term" value="C:amyloid-beta complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043198">
        <property type="term" value="C:dendritic shaft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043197">
        <property type="term" value="C:dendritic spine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005798">
        <property type="term" value="C:Golgi-associated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030426">
        <property type="term" value="C:growth cone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005641">
        <property type="term" value="C:nuclear envelope lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043204">
        <property type="term" value="C:perikaryon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099503">
        <property type="term" value="C:secretory vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120283">
        <property type="term" value="F:protein serine/threonine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051425">
        <property type="term" value="F:PTB domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048018">
        <property type="term" value="F:receptor ligand activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990000">
        <property type="term" value="P:amyloid fibril formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002265">
        <property type="term" value="P:astrocyte activation involved in immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007409">
        <property type="term" value="P:axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904646">
        <property type="term" value="P:cellular response to amyloid-beta"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007612">
        <property type="term" value="P:learning"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014005">
        <property type="term" value="P:microglia development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001774">
        <property type="term" value="P:microglial cell activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098815">
        <property type="term" value="P:modulation of excitatory postsynaptic potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
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    <evidence type="ECO:0000256" key="34">
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            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="35">
        <source>
            <dbReference type="ARBA" id="ARBA00023087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="36">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="37">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="38">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="39">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="40">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="41">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="42">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="43">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="44">
        <source>
            <dbReference type="RuleBase" id="RU367156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="45">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="46">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="47">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="48">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="49">
        <source>
            <dbReference type="PROSITE" id="PS51869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="50">
        <source>
            <dbReference type="PROSITE" id="PS51870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="51">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005004836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="52">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="751" mass="84708" checksum="349F341DC9C75C90" modified="2022-01-19" version="1">MLPHLALLLLAAGVARALEVPADGNAGLLAEPQIAMFCGKLNMHMNVQNGKWEPDPSGTKSCIGTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGWKQCNGHPHIVVPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKESCSEKSMNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNLDSADAEDDDSDVWWGGADADYADGSDDKVVEEQPEEDEELTVVEDEDADDDDDDDGDEIEETEEEYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDMAEGKCAPFFYGGCGGNRNNFDSEEYCMAVCGSVLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEATLNDRRRIALENYITALQTVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSFLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVDGEFSLDDLQPWHPFGVDSVPANTENEVEPVDARPAADRGLTTRPGSGLTNVKTEEVSEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T023</accession>
    <name>A0A8C2T023_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Ceramide synthase 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">CERS4</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>sphinganine + octadecanoyl-CoA = N-(octadecanoyl)-sphinganine + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36547"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57394"/>
            <dbReference type="ChEBI" id="CHEBI:57817"/>
            <dbReference type="ChEBI" id="CHEBI:67033"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:36548"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T023"/>
    <dbReference type="Ensembl" id="ENSCJPT00005009421.1">
        <property type="protein sequence ID" value="ENSCJPP00005005904.1"/>
        <property type="gene ID" value="ENSCJPG00005005576.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234515"/>
    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050291">
        <property type="term" value="F:sphingosine N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000020">
        <property type="entry name" value="Ceramide synthase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016439">
        <property type="entry name" value="Lag1/Lac1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560:SF6">
        <property type="entry name" value="CERAMIDE SYNTHASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560">
        <property type="entry name" value="LONGEVITY ASSURANCE FACTOR 1 LAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005225">
        <property type="entry name" value="LAG1_LAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12 14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12 14" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 13 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="305"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="17">
        <location>
            <begin position="69"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="18">
        <location>
            <begin position="133"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="12">
        <location>
            <begin position="71"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005005904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="400" mass="47785" checksum="2C6F65B025651E45" modified="2022-01-19" version="1">MRMAHSLNEWLWQHKFWLPPGITWEDMKESEDIHYPKPRDLLLSIPFALILVVIRCVFERAIALPISAKLGVKDKLRPKAQPISILETFYTVNCKNPKEGELISLAKQCDLPVRKVERWFRRRRNTDRPSLSKKFCEACWRFTFYIVSFFTGLGVLYDKPWLWDHRECWTGYPQQPLQPSLFWYYMLELSFYCSLVFTLPFDVKRKDFKEQIVHHAATIFLISFSYCANYIRIGTLVMVIHDASDCFLEPTKIFNYMKWKKTCDSLFMIFSAVFLISRLVIFPYTVLYNTYYYSMEIFQPFFGYYFVNALLITLQLLHIFWSCLIIHMVYKFMLQGTMEKDMRSETEESDVDEERENMMEKEKNGIAHFSNVTNRNYIQRNGSEPLNNRAHLTNGHVKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T0J6</accession>
    <name>A0A8C2T0J6_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Glucose-6-phosphatase catalytic subunit 1</fullName>
            <ecNumber evidence="5">3.1.3.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Glucose-6-phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">G6PC1</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production in the terminal step of glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glucose 6-phosphate + H2O = D-glucose + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16689"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="3.1.3.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glucose-6-phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.9" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2T0J6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005009162.1">
        <property type="protein sequence ID" value="ENSCJPP00005005691.1"/>
        <property type="gene ID" value="ENSCJPG00005005382.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183150"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004346">
        <property type="term" value="F:glucose-6-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042301">
        <property type="term" value="F:phosphate ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042632">
        <property type="term" value="P:cholesterol homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051156">
        <property type="term" value="P:glucose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042593">
        <property type="term" value="P:glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015760">
        <property type="term" value="P:glucose-6-phosphate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035264">
        <property type="term" value="P:multicellular organism growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061771">
        <property type="term" value="P:response to caloric restriction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046415">
        <property type="term" value="P:urate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd03381">
        <property type="entry name" value="PAP2_glucose_6_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.144.10:FF:000010">
        <property type="entry name" value="Glucose-6-phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016275">
        <property type="entry name" value="Glucose-6-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12591">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12591:SF3">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000905">
        <property type="entry name" value="Glucose-6-phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="150"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="293"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="322"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="19">
        <location>
            <begin position="57"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="16">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="16">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000905-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000905-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005005691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="358" mass="40608" checksum="256DFC68AF68B3E9" modified="2022-01-19" version="1">MEAPMNLLHDAGIQATYWLQKHFQGSQDWFLFISFAADLRNTFFVLFPIWFHLCEPVGIRLIWVAVIGDWLNLVFKWILFGERPYWWVHETDYYSNTSAPAIQQFPLTCETGPGSPSGHAMGAAGVYYVMVTALLSIAMGKEKSKTLKYWILWAVLWMGFWAVQVCVCLSRIFIAAHFPHQVIAGVISGMAVAETFQHVHSIYRASLRRYLGVTFFLFSFALGFYLLLRMLGVELLWTLEKAQRWCAHPEWVHIDTTPFASLLRNLGILFGLGLALSSHMYLESCRGKQGRQLSFRLGCAAASLLVLHLFDAFKPPSHMQLLFYVLSFCKSAAVPLATVGLIPYCISQFLATQDKKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T239</accession>
    <name>A0A8C2T239_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Sulfotransferase</fullName>
            <ecNumber evidence="13">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">CHST3</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>3'-phosphoadenylyl sulfate + keratan = adenosine 3',5'-bisphosphate + keratan 6'-sulfate.</text>
            <dbReference type="EC" id="2.8.2.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>chondroitin beta-D-glucuronate + n 3'-phosphoadenylyl sulfate = chondroitin 6'-sulfate + n adenosine 3',5'-bisphosphate + n H(+)</text>
            <dbReference type="Rhea" id="RHEA:11108"/>
            <dbReference type="Rhea" id="RHEA-COMP:9827"/>
            <dbReference type="Rhea" id="RHEA-COMP:9828"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57652"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:62065"/>
            <dbReference type="EC" id="2.8.2.17"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:11109"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="13"/>
    <dbReference type="RefSeq" id="XP_015721958.1">
        <property type="nucleotide sequence ID" value="XM_015866472.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032301407.1">
        <property type="nucleotide sequence ID" value="XM_032445516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T239"/>
    <dbReference type="Ensembl" id="ENSCJPT00005011307.1">
        <property type="protein sequence ID" value="ENSCJPP00005007298.1"/>
        <property type="gene ID" value="ENSCJPG00005006732.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107315769"/>
    <dbReference type="KEGG" id="cjo:107315769"/>
    <dbReference type="CTD" id="9469"/>
    <dbReference type="GeneTree" id="ENSGT00940000161045"/>
    <dbReference type="OrthoDB" id="6138663at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008459">
        <property type="term" value="F:chondroitin 6-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045130">
        <property type="term" value="F:keratan sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001517">
        <property type="term" value="F:N-acetylglucosamine 6-O-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050650">
        <property type="term" value="P:chondroitin sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043029">
        <property type="term" value="P:T cell homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000938">
        <property type="entry name" value="Sulfotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016469">
        <property type="entry name" value="Carbohydrate_sulfotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051135">
        <property type="entry name" value="Gal/GlcNAc/GalNAc_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10704">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10704:SF60">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005883">
        <property type="entry name" value="Carbohydrate_sulfotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfotransferase" evidence="15">
        <location>
            <begin position="113"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00036278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005007298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="458" mass="52095" checksum="3FE8E7208BB0BF07" modified="2022-01-19" version="1">MERRSALPQDFREVLHCLKMRSKYAVLLVFVVGLVIIEKENNFISRVSDKLKQSPQVLPEANETEASPVQAENGSLASLRQLDTAFSQLRTRLRNVTLQLAGELGMAAPGPRRHVLLMATTRTGSSFVGEFFNQQGNIFYLFEPLWHIERTVTFEPGGANAVGSALVYRDVLQQLLLCDLYILESFISPAPEEHLTAALFRRGSSRSLCEEPVCTPGLKKVFEKYHCKNRRCGPLNITLAAEACRRKQHMALKTVRIRQLEFLQPLAEDPRLDLRVIQLVRDPRAVLASRMVAFSGKYESWKKWAAEGEAPLQEDEVQRLRGNCESIRLSAELGLRQPRWLQGRYMLVRYEDVARAPLRKALEMYRFAGIRPTPQVEEWIRTNTQAPQDGNGIYSTQKNSSEQFEKWRFSIPFKLAQVVQDACEPAMRLFGYKLASSAQELTNRSLSLLEEGPPTQVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T2N3</accession>
    <name>A0A8C2T2N3_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sulfiredoxin-1</fullName>
            <ecNumber evidence="2">1.8.98.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">SRXN1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4. Does not act on PRDX5 or PRDX6. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>S-hydroxy-S-oxy-L-cysteinyl-[peroxiredoxin] + [protein]-dithiol + ATP = S-hydroxy-L-cysteinyl-[peroxiredoxin] + [protein]-disulfide + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17545"/>
            <dbReference type="Rhea" id="RHEA-COMP:10593"/>
            <dbReference type="Rhea" id="RHEA-COMP:10594"/>
            <dbReference type="Rhea" id="RHEA-COMP:13681"/>
            <dbReference type="Rhea" id="RHEA-COMP:17976"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:61973"/>
            <dbReference type="ChEBI" id="CHEBI:61974"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="1.8.98.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfiredoxin family.</text>
    </comment>
    <dbReference type="EC" id="1.8.98.2" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2T2N3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005009831.1">
        <property type="protein sequence ID" value="ENSCJPP00005006213.1"/>
        <property type="gene ID" value="ENSCJPG00005005830.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000007832"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032542">
        <property type="term" value="F:sulfiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16395">
        <property type="entry name" value="Srx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1530.10:FF:000001">
        <property type="entry name" value="Sulfiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1530.10">
        <property type="entry name" value="Conserved hypothetical protein from pyrococcus furiosus pfu- 392566-001, ParB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016692">
        <property type="entry name" value="Sulfiredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21348">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21348:SF2">
        <property type="entry name" value="SULFIREDOXIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="ParB/Sulfiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB-like N-terminal" evidence="12">
        <location>
            <begin position="60"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00059800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="154" mass="16261" checksum="8AE3470D1FF2729B" modified="2022-01-19" version="1">MAAGGGRAALRGAALCGAGGGGAGRGAAERRPEVAEVAMAEQEGNGDTGSIHTQHIAAVHNVPISVLIRPIPSVLEPEKVRSLVRTLQDPERVPPIDVLWIKGSQGGDYFYSFGGCHRYAAHRELNRDTIPAKIIPSTISDLRTYLGSSTPELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T420</accession>
    <name>A0A8C2T420_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Zinc finger and BTB domain-containing protein 48</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Telomere zinc finger-associated protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="primary">ZBTB48</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Plays a critical role in transcriptional regulation and chromatin remodeling. Acts as a regulator of telomere length. Directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. Preferentially binds to telomeres that have a low concentration of shelterin complex and acts as a regulator of telomere length by initiating telomere trimming, a process that prevents the accumulation of aberrantly long telomeres. Also acts as a transcription regulator that binds to promoter regions. Regulates expression of a small subset of genes, including MTFP1. Acts as a negative regulator of cell proliferation by specifically activating expression of ARF, a tumor suppressor isoform of CDKN2A. Acts as a transcription regulator of CIITA, the major factor regulating MHC class II gene expression. In addition, regulates cellular m6A/m6Am methylation on RNA by facilitating the recruitment of the RNA demethylase, FTO, to target mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="18">Interacts with EP300.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015738051.1">
        <property type="nucleotide sequence ID" value="XM_015882565.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T420"/>
    <dbReference type="Ensembl" id="ENSCJPT00005012543.1">
        <property type="protein sequence ID" value="ENSCJPP00005008235.1"/>
        <property type="gene ID" value="ENSCJPG00005007402.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107323456"/>
    <dbReference type="KEGG" id="cjo:107323456"/>
    <dbReference type="CTD" id="3104"/>
    <dbReference type="GeneTree" id="ENSGT00940000158981"/>
    <dbReference type="OrthoDB" id="3156061at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003691">
        <property type="term" value="F:double-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010833">
        <property type="term" value="P:telomere maintenance via telomere lengthening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd18232">
        <property type="entry name" value="BTB_POZ_ZBTB48_TZAP_KR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000657">
        <property type="entry name" value="GDNF inducible zinc finger protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001732">
        <property type="entry name" value="Zgc:162936"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001113">
        <property type="entry name" value="Zinc finger and BTB domain containing 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001117">
        <property type="entry name" value="Zinc finger and BTB domain containing 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000809">
        <property type="entry name" value="Zinc finger and BTB domain-containing 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001252">
        <property type="entry name" value="Zinc finger and BTB domain-containing 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001257">
        <property type="entry name" value="Zinc finger and BTB domain-containing 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050636">
        <property type="entry name" value="C2H2-ZF_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47772:SF13">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47772">
        <property type="entry name" value="ZINC FINGER PROTEIN 200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
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        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0779">Telomere</keyword>
    <keyword evidence="15" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 21" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="25"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="24">
        <location>
            <begin position="203"/>
            <end position="230"/>
        </location>
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    <feature type="domain" description="C2H2-type" evidence="24">
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            <end position="258"/>
        </location>
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    <feature type="domain" description="C2H2-type" evidence="24">
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            <begin position="262"/>
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    <feature type="domain" description="C2H2-type" evidence="24">
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            <end position="318"/>
        </location>
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    <feature type="domain" description="C2H2-type" evidence="24">
        <location>
            <begin position="319"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="24">
        <location>
            <begin position="348"/>
            <end position="376"/>
        </location>
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    <feature type="domain" description="C2H2-type" evidence="24">
        <location>
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    <feature type="domain" description="C2H2-type" evidence="24">
        <location>
            <begin position="405"/>
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        </location>
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    <feature type="domain" description="C2H2-type" evidence="24">
        <location>
            <begin position="433"/>
            <end position="461"/>
        </location>
    </feature>
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        <location>
            <begin position="462"/>
            <end position="489"/>
        </location>
    </feature>
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        <location>
            <begin position="490"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="115"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00058760"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00065772"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00070976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00081963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005008235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="599" mass="67600" checksum="936892DE5B898F60" modified="2022-01-19" version="1">MPGAAAHSVRVLRELNRQRAAGQFCDATLGVGGREFRAHWPVLASCSRFFRSRGSVGPGPVSLPDAVADTFQLLLDFFYTGRLALTAHNRSRLLSAAELLGVPDAVALCRSFRPARRRSRRAPGPAPRPDEPGEQLGTAGPDTERPGTDSAATANVAPPASSDTAGGGTGSGDNEPRDEKEELGDKGKHLERGPGRKGNTAPVECPTCHKSFLSKYYLKVHNRKHTGEKPFECSKCGKCYFRKENLLEHEARNCMNRTEQVFTCSVCQEVFKRRMELRLHMVSHTGEMPYKCSSCVQQFMQKKDLQSHMIKLHGAPKPHACSTCSKCFLSRTELRLHEAFKHRGEKLFVCEECGHRASSRNGLQMHIKAKHRNERPYVCEFCHHAFTQKANLNMHLRTHTGEKPFQCHLCGKTFRTQASLDKHNRTHTGERPFSCEFCEQRFTEKGPLLRHIASRHQEGRPHFCQICGKTFKAVEQLRVHVRRHKGVRKFECTECGYKFTRQAHLRRHMEIHDRVENYNPRQRKLRNLIIEDEKAVVVALQPPQELEVGSAEVIVESLSHGPLPEEIPVQRLCSNDSFSPDVIEQSLIITTTIPADCET</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T4V7</accession>
    <name>A0A8C2T4V7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein RFT1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">RFT1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8 9">Intramembrane glycolipid transporter that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. RFT1 could mediate the translocation of the cytosolically oriented intermediate DolPP-GlcNAc2Man5, produced by ALG11, into the ER lumen where dolichol-linked oligosaccharides assembly continues. However, the intramembrane lipid transporter activity could not be confirmed in vitro.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Endoplasmic reticulum membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the RFT1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T4V7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005012974.1">
        <property type="protein sequence ID" value="ENSCJPP00005008571.1"/>
        <property type="gene ID" value="ENSCJPG00005007649.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000011390"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034203">
        <property type="term" value="P:glycolipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007594">
        <property type="entry name" value="RFT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13117">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MULTISPAN TRANSMEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13117:SF5">
        <property type="entry name" value="PROTEIN RFT1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04506">
        <property type="entry name" value="Rft-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="413"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="457"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="488"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="511"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="545"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="581"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005008571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="622" mass="68891" checksum="C133421AD816F6FE" modified="2022-01-19" version="1">MGTAPGAKSTTAQLCGAVSATKRRVSALSLPAAPCFGQQRTRAECGAAKSCMARSGAFLSCPCPQCCNAPHHCAHTRCLCSIHIHKWSWTPLAAISPHTEAVHCIAAHPAVSPRRHLLTGTTRVGFSSAAVRPLVTSSRRDAVLPAGRSVSWRPSVLSVRPPAWPRPAPCCRVPLGVFWSVFLGFVWLHVLEVPDPSVVPHYQAGVVAFGLSAVVELLGEPFWVLAQAHLFVRLKVIAESLSIVSKCTLTVILVILYPQWGLHIFSLAQLLYTSVLVLCYVVCFAKFLGSPEATKKSFPITRMKGLLPNWMADKAFLNWKEAWLTWSFFKQSFLKQILTEGERYVMTFLNVINFGDQGVYDIVNNLGSLVARFIFLPIEESFYVFFAQVLERGKNVKDQKQDDVAMASNVLELLLKLVLLIGLTIAVFGCAFSQLALDIYGGSMLSSGTGPDLLRCYSLYVLFLAVNGVTECFTFASMCKEEVDRYNFVMLALSFVFLCISYFLTRWHGSVGFILANCFNMGIRIAHSIQYIYEYFKESSYRPLTGLLPSPFLILAYVISGGITVYSEAFFCCDKGWMSRLIHISIGALCFAATTITMFCTETKLVHFVRSQFLSQYMKKGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T6F9</accession>
    <name>A0A8C2T6F9_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ADP dependent glucokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ADPGK</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015727866.1">
        <property type="nucleotide sequence ID" value="XM_015872380.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T6F9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005012681.1">
        <property type="protein sequence ID" value="ENSCJPP00005008341.1"/>
        <property type="gene ID" value="ENSCJPG00005007481.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107318502"/>
    <dbReference type="KEGG" id="cjo:107318502"/>
    <dbReference type="CTD" id="83440"/>
    <dbReference type="GeneTree" id="ENSGT00390000017953"/>
    <dbReference type="OrthoDB" id="5847021at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043843">
        <property type="term" value="F:ADP-specific glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01938">
        <property type="entry name" value="ADPGK_ADPPFK"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007666">
        <property type="entry name" value="ADP_PFK/GK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21208">
        <property type="entry name" value="ADP-DEPENDENT GLUCOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21208:SF0">
        <property type="entry name" value="ADP-DEPENDENT GLUCOKINASE"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Ribokinase-like"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51255">
        <property type="entry name" value="ADPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
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    <feature type="chain" id="PRO_5034327721" evidence="6">
        <location>
            <begin position="17"/>
            <end position="490"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005008341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="490" mass="52941" checksum="B7F1B5DBC5717348" modified="2022-01-19" version="1">MWRRSVCVGLLALALGYLCLLGPPLPPAVLQHLPASLLGGLSRAGSLESRMVAAWQAAIVRPARGWGRVAVGVNACVDVVVSGVKLLEALGLKPGSGKNHDVLNSGQDLREAFTHFMEKGAAAERFFSDAESFHHIAQAASEHPGAQLYVGGNAALIGQKLAANPDLKVLLCGPVGPKLHELLDDNVVVPPESMQERDEFHLILEYQAGEEWGQVKAPNANRFIFSHDLSNGALNMLEVFVSSLEEFQPDLVVLSGLHMMEGQSKEMRRRRLMEAVASISDIPTDIPIHLELASMTDQDFMSNIVHQQVFPLVNSIGLNEQELLFLTQSASGPHASLASWNGIPDVGAVSDILFWILKEHGKTADRASDLTRIHFHTLAYHILVTVDGHWGNQVAAVAAGARAAGAQACATETIDTSKVFLKAPLEFVTSQIEAPSKISLNPDEPVVHWHREGISFHFTPVLVCKDPVRTVGLGDAISAEGLLYSEINLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T6P0</accession>
    <name>A0A8C2T6P0_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Inhibitory synaptic factor family member 2B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">INSYN2B</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015731438.1">
        <property type="nucleotide sequence ID" value="XM_015875952.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T6P0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005012311.1">
        <property type="protein sequence ID" value="ENSCJPP00005008050.1"/>
        <property type="gene ID" value="ENSCJPG00005007276.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107320252"/>
    <dbReference type="KEGG" id="cjo:107320252"/>
    <dbReference type="CTD" id="100131897"/>
    <dbReference type="GeneTree" id="ENSGT00530000063787"/>
    <dbReference type="OrthoDB" id="8679980at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029337">
        <property type="entry name" value="INSYN2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28682">
        <property type="entry name" value="INHIBITORY SYNAPTIC FACTOR 2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28682:SF2">
        <property type="entry name" value="PROTEIN INSYN2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15265">
        <property type="entry name" value="FAM196"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="516"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="538"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005008050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="553" mass="62283" checksum="B0D3EEC259DBE4C7" modified="2022-01-19" version="1">MTNVMGRRETHYLQTLNCDSMAQQNMKMRPVLLKRNSLDSFDFMRQPHHRRSKSQQVRFKDDGINTKTVDVTELDNNPAQDIELLIENSEISPHHNFLLQPPSFPKAQKGLQNIAIQTSPSLRKHFPVFRRKKLLVSKSLTEMPSEPADCIPVNDRLSEQDIMSSDFCYLRISSHLEDGFRNSTVDGQSSQRLPEAQRNGHIQTNDSSATEKTTASTHVPEYIHVNFSQNSDTSMDATDPTMNLSNLIHSSKSSTIINSNENNETSMLSSNSEIIYPCLSDSTNSNDCNPQSDSCETANSGSALLAVSEDPNTKETTPLSPASNQSSSPCFLRNYLQTVENKTDSSCVKVTNDDHTVMSLTSSNASKSISSVSTETEKNSTLSDVSQCNSCFEGLHTKSYLPRNEIKPHINKEISEINQIHLTHGELCALQGKLHSVEESLLSNQEKIKVLLNVIQDLEKSRALSEGRNFYHTGQDLNNCSTCQNTACIIYSVEYDFRQQEGRFQQILKRLDHAEQNPAAASPQKPSFDQPLPEKKELRKKTKKMKKKCFWWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T790</accession>
    <name>A0A8C2T790_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">KASH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus outer membrane</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the nesprin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T790"/>
    <dbReference type="Ensembl" id="ENSCJPT00005012897.1">
        <property type="protein sequence ID" value="ENSCJPP00005008525.1"/>
        <property type="gene ID" value="ENSCJPG00005007549.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154481"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005640">
        <property type="term" value="C:nuclear outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000041">
        <property type="entry name" value="Nesprin-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000115">
        <property type="entry name" value="nesprin-2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000126">
        <property type="entry name" value="Spectrin repeat containing, nuclear envelope 1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000248">
        <property type="entry name" value="Synaptic nuclear envelope 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012315">
        <property type="entry name" value="KASH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056887">
        <property type="entry name" value="SYNE1/2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14514:SF3">
        <property type="entry name" value="NESPRIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14514">
        <property type="entry name" value="PKA ANCHORING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10541">
        <property type="entry name" value="KASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25035">
        <property type="entry name" value="SYNE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01249">
        <property type="entry name" value="KASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51049">
        <property type="entry name" value="KASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="topological domain" description="Cytoplasmic" evidence="9">
        <location>
            <begin position="1"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="925"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="topological domain" description="Perinuclear space" evidence="9">
        <location>
            <begin position="946"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="domain" description="KASH" evidence="12">
        <location>
            <begin position="916"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="401"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="856"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="402"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="858"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="891"/>
            <end position="909"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005008525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="975" mass="111911" checksum="8AB357EBAEAFB65F" modified="2022-01-19" version="1">MVVAEDLRAVRMAEDGSVDSDLPDCNCDITRVKKLKETLVAVQQLDKNMSSLRSWLAHIESELSKPIVYETCDSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATETECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKNSERTAAFPSSSGVLYTVAKEELKKFEAFQRQVHESLTQLELINKQYRRLARENRTDSASKLKQMVHEGNQRWDNLQKRVTSILRRLKHFISQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNNNKIQQIIIQGEQLIEKSEPMDAAVIEEELDELRRYCQEVFGRVERYHKKLIRLPLTDDEHDLSDREVDLDESADLSDIHWHDKSADSVLSPHPSSNLSLPIAQPVRSERSGRDTPASVDSIPLEWDHDYDLSRDLETAVSRALHSEEEDGEQEKDFYLRGAASIADVEIPETLEAYVELTENALKNISGEPGALEAHIRQLDKALDTSRFQIQQTENIIRSKTPTGPELDATYKGYMKLLGECSGSIDSVKRLGYKLKEEEEKLSGLINLNSTETQTAGVIDRWELIQAQALSKELRMKQNLQQWQQFNSDLNSIWAWLGETEEELEKLRCLDLSTDIQTIELRIRKLKELQKAIDNRKAIILSINLCSSEFTQSDSEESKKLQERLTQMNVRWDHVCSMIEEWRCSLQDALMQCQDFHEMSHGLLLWLENIDRRKNEIVPINPNLDSEILQDHHRLLMQIRRELLESQLKVASLQDMSCQLLVNAEGKDCLEAKEKVHVIGNRLKLLLKEVIRHIKDLEKALDISSSQLDLSSWSSADELDTSGSVSPVSGQSTPSRQRTPRGKCSLSQPGPSVSSPHSRSTRGGSGSSPSEAGPAWQHPSFFLRVLRAALPLQLFLLLLIGLACLVPMTEEDYSCTMANNFARSFHPMLKYMNGPPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T858</accession>
    <name>A0A8C2T858_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Extracellular tyrosine-protein kinase PKDCC</fullName>
            <ecNumber evidence="3">2.7.10.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Protein kinase domain-containing protein, cytoplasmic</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">Protein kinase-like protein SgK493</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">Sugen kinase 493</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="24">Vertebrate lonesome kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="primary">PKDCC</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="28" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="28" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:10597"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2T858"/>
    <dbReference type="Ensembl" id="ENSCJPT00005014527.1">
        <property type="protein sequence ID" value="ENSCJPP00005009766.1"/>
        <property type="gene ID" value="ENSCJPG00005008549.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000001205"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030282">
        <property type="term" value="P:bone mineralization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048566">
        <property type="term" value="P:embryonic digestive tract development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035108">
        <property type="term" value="P:limb morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035264">
        <property type="term" value="P:multicellular organism growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042997">
        <property type="term" value="P:negative regulation of Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030501">
        <property type="term" value="P:positive regulation of bone mineralization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032332">
        <property type="term" value="P:positive regulation of chondrocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060021">
        <property type="term" value="P:roof of mouth development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001501">
        <property type="term" value="P:skeletal system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000552">
        <property type="entry name" value="extracellular tyrosine-protein kinase PKDCC isoform X5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022049">
        <property type="entry name" value="FAM69_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042983">
        <property type="entry name" value="PKDCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46448:SF3">
        <property type="entry name" value="EXTRACELLULAR TYROSINE-PROTEIN KINASE PKDCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46448">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12260">
        <property type="entry name" value="PIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="12" id="KW-0221">Differentiation</keyword>
    <keyword evidence="18" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0892">Osteogenesis</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-0653">Protein transport</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 26" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="17" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="signal peptide" evidence="26">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034875727" description="Extracellular tyrosine-protein kinase PKDCC" evidence="26">
        <location>
            <begin position="30"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="27">
        <location>
            <begin position="150"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="32"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="105"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="25">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="25">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00051942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00072258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00078617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00079014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00080589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00082327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005009766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="583" mass="65219" checksum="CF26AEB14B8E899C" modified="2022-01-19" version="1">MRRRKTAVAAACCLALLLGTLLNVLFVPGSELPPPSPPPPRDGAPPSPPGAPLEPPEEEGGGGGRAALARQLRERYEEVLRYRQPRAAGVRRAVRPRERRLMDLAPARTSAEQQQQQQQPRGRAAAERGRASAELGLEPPPLGCRELRAAGGVQYLGSGYTKAVYKAVLNRSLAVALKAVDFGGHDVSRCVRQFASLADCYRLAAYKIVKEMVLLQRLRHANVLQLYGYCYQDSNDIPDTLTAITELGSPLEMIQLLQTSWEDRFRICLSLVRLLHYLAHSPLGSVTLLDFRPRQFVIVDGELKVTDLDDASIEESSCTSNSDCFMEFPARNFTLPCSVEGRCQNMNEKRNLYNAYRFFFTYLLPHSAPPSLRPLLDKIVNATGRAWSLVQSSLWPCGVWRVPASNKGIHNCQQDAYLPVTSGELQWGIDETAAQLERVLNLYKSGEYLQNATRISKSEYRRVPEAFIPDENYRCWPSYHHKGCLLSVFDVNEAMEICDSYSQCKAFVLTNQTTWTGRSWMLLKGTPVFCFRQNSCRGDKRSLPSVSRVRCASHGPTCGFSHNFPSHVIVAVFHKSKRVLPCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T866</accession>
    <name>A0A8C2T866_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ZDHHC14</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2T866"/>
    <dbReference type="Ensembl" id="ENSCJPT00005013408.1">
        <property type="protein sequence ID" value="ENSCJPP00005008909.1"/>
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        <property type="component" value="Chromosome 3"/>
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        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="P:protein targeting to membrane"/>
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        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
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        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
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        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC14"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
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        <property type="entry name" value="DHHC"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="83"/>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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            <begin position="211"/>
            <end position="236"/>
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        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="9">
        <location>
            <begin position="165"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
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    <sequence length="491" mass="53859" checksum="D854768BAF16BA52" modified="2022-01-19" version="1">MTPGGGSGPMKDCEYSQISTHSSSSPMESPHKKKKPAPKRKWEVFPGRNKFFCNGRIMMARQTGVFYLTLVLILVTSGLFFAFDCPYLSEKITPAIPAIGGILFFFVMGTLLRTSFSDPGVLPRATPDEAADLERQIDIANGSSSGGYRPPPRTKEVIINGQTVKLKYCFTCKIFRPPRASHCSLCDNCVERFDHHCPWVGNCVGKRNYRFFYMFILSLSFLTVFIFAFVITHVILRSQQAGFLNALKDSPARYPFTVVCFFSVWSIVGLSGFHTYLISSNQTTNEDIKGSWSNKRGKENYNPYSYGNIFTNCCAALCGPLSPSLIDRRGFIQPDTPQLAGPSNGITMYGATQSQSNMCDQDQCIQSTKFVLQAAATPLLQSEPSINSEELPLPGKTSISGPCATLTLGQPTPPSSMPNLTSDTGLTDMIPLKEEHEGHQFLTPEEAPSPPGMLPSGSPITHSHTMHVLSLASQDSLHEDSVRGLVKLSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T8K0</accession>
    <name>A0A8C2T8K0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">P-type phospholipid transporter</fullName>
            <ecNumber evidence="2">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ABCA4</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 17">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005013294.1">
        <property type="protein sequence ID" value="ENSCJPP00005008818.1"/>
        <property type="gene ID" value="ENSCJPG00005004231.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155624"/>
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        <property type="component" value="Chromosome 8"/>
    </dbReference>
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        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001750">
        <property type="term" value="C:photoreceptor outer segment"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:11-cis retinal binding"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
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        <property type="term" value="F:all-trans retinal binding"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0140347">
        <property type="term" value="F:N-retinylidene-phosphatidylethanolamine flippase activity"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0045494">
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:retinal metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd03263">
        <property type="entry name" value="ABC_subfamily_A"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ATP-binding cassette, sub-family A (ABC1), member 1"/>
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    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000264">
        <property type="entry name" value="ATP-binding cassette, sub-family A (ABC1), member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056264">
        <property type="entry name" value="R2_ABCA1-4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF190">
        <property type="entry name" value="RETINAL-SPECIFIC PHOSPHOLIPID-TRANSPORTING ATPASE ABCA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12698">
        <property type="entry name" value="ABC2_membrane_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23321">
        <property type="entry name" value="R1_ABCA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="655"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="695"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="731"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="758"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1642"/>
            <end position="1664"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1694"/>
            <end position="1711"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1723"/>
            <end position="1741"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1753"/>
            <end position="1778"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="911"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="1900"/>
            <end position="2132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012189"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005008818.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="2292" mass="258239" checksum="AA5EFADEC7AC9509" modified="2022-01-19" version="1">MSFLRQIRLLLWKNWILRKRQKLRILVELIWPLSLFLVLVWLRKANPLYRQHECHFPNKAMPSAGTLPWIQGIICNMNNPCFSSPTRGEGPGVVSNYNNSILARVYKDAQELLLEAPEIHDLGRVWEELIIMTQFMETMRTNPERIAGRGIRILDILKDGETLTSFLLENAGLPDTVVFQLVNAQVRPEQFAYGVPNLTLKEIACSQKLLDRFIIFSSRRALPSVHKAMCALSQESLQRVEDALYANVDLFKLFQLLPSVLDRNSPGADLRSWGRVLSNVSQSVQKVSARKQSVQDLLMVLQPFVQDGMPGSLGHLVSSLSDLFCGYPEGGGSRVLSFNWYEDNNYKAFLGIDSTKKSIYLYDNTTTPFCNELIQGLESNPLTKIAWSAVKPLLMGKILFAPSSPPVQQIIKNANSTFEELERLRLLTKAWEEVGPQLWHFFQNSLQMNMIRSSLNHSTVRDFLNSQLGAEGLTAEYIINFLHNGPPGSREKGMVDFDWRNIFSAADQALRLLNQYLECLTLDKFEGYSDESQLTHQALHLLEENKFWAGVVFPDIDPTQKSLPPHVKYKIRMDIDAVEKTNKIKDRYWDPGPRADPVDDLRYIWGGFAYLQDMIEHGIIKTQTNTEVALGIYLQQMPYPCFVDDVFMITLNRSFPIFMVLAWIYSVSMTVKSIVLEKEMRLKEAMKNRGITNGVIWCTWFLDSFFMMAVSTFLLTALIMHGQVLHYSNPLLFFLFLLTFTTATIMQCFLFSTFFSKANLAAACSGVLYFTLYLPHIVCFVWQDHMTVTLKILASLLSQVAFGFGTEYLSRYEEQGLGLQWGNIRTSPLEGDEYSFLFSIKMMLFDAFLYGILSWYLDHVFPGDYGLPQPWYFPLQESYWLGSRNPKAEKTATADVNTFCEPEPTGLIPGVCIQNLVKIFANRPKPAVDRMNMTFYEGQITAFLGHNGAGKTTTMSILTGLFPPTSGTVLIGGLDIQTHMDSIRQRLGMCPQYNILFNHLTVEEHILFYSQLKGRSRDEAEQELEMMLEDMGLTHKRNEEAQNLSGGMQRKLSVAIAFVGEAKVVVLDEPTSGVDPYSRRSIWDLLLKYRSGRTIILSTHHMDEADILGDRIAIISQGKLFCSGSPVFLKNCFGSGFYLTLVRKVKNTRTGRNSLCSCGSQCSCSCSSCAHNDEEGTQEQELGGDLNELAEVIHHHVPEAKLIENIGQELVYLLPNKHFKQRSYASLFRELEETLDDLGLSSFGVSDTPLEEVFLKVTAEADTEVVFLNVGDIQENDSTPGKISTENKAAEQTPVEINNTSRMPVGTAGDQNEGKGSLQYKGFQLVHQQFKALIIKRFHHASRSYKDFLTQIVLPASFVLLSLVLTVIIPPFGEYPALTLDPWIYGQQFTFFSNERPGSEQMVSLTNAFLNKPGFGNRCLKNQPLLNYPCNNMPTAWNIPAVHPNLSSLLLNQKWSSENPSPSCKCSTDKKLIMLPECPPGAGGLPPPQRVQHSTEILQDLTHRNISDFLVKTYPILIKGSLKSKYWVNEQRYGGISIGGKLPVLHVSGDEVVNFLSNLGRMMNVTGVRFVWSLYPRIVWFNNKGWHAMVSFLNVANNAVLRANLRTGQAPEEYGITVVNHPLNLTKEQLSEVTVLTTSVDAVVAICVIFAMSFIPASFVLYLIQERVTKAKHLQFVSGVSPAIYWLTNFMWDIVNYAVSAGLVVVIFIGFKKKAYTSRTNLPVFVALLLLYGWAVIPMMYPASSFFSVPSTAYVALSCINLFVGINSSAITFILELFENNPALLKFNKTLKNVLIVFPHFCLGRGLIDLAINQAVSEVYARFGEEHVSNPFQWDFVGKNLVAMAVQGVAFFTLNLLMQHRLLPSRWFTETAESPIIGEDEDVAEERKRILSGGNKTNILELRELTKIYAGRHKPAVDRLCVGIRPGECFGLLGVNGAGKTTTFSMLTGDIEVTSGDAVVAGSSILTQISNVHQNMGYCPQFDALDDLLTGREHLYLYARLRGVPAEEIKRVAEWGIQKLGLPMYADQLAGTYSGGNKRKLSTAIALIGCPPLILLDEPTTGMDPQSRRLLWDSIVSVLRDGRAVVLTSHSMEECEALCTRLAIMVKGTFKCLGTIQQLKYKFGDGYIVTLKIKAPKTGLPPDPSRAEQFIRINFPGSLQREKHYNMLQYQICSSSLAKIFRLIISNKENLYIEEYSVSQTTLDQVFVNFAKQQVEDEEIPLHPRAAGSNRETKVTPCKITKLQTDSQLCIASFIQESFRFQKNLQRVLYRNKRWVTYFAFLVFSSIYVDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T8M9</accession>
    <name>A0A8C2T8M9_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Msh homeobox 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">MSX2</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the Msh homeobox family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015731904.1">
        <property type="nucleotide sequence ID" value="XM_015876418.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T8M9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005015039.1">
        <property type="protein sequence ID" value="ENSCJPP00005010111.1"/>
        <property type="gene ID" value="ENSCJPG00005008848.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107320497"/>
    <dbReference type="KEGG" id="cjo:107320497"/>
    <dbReference type="CTD" id="4488"/>
    <dbReference type="GeneTree" id="ENSGT00940000159824"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048598">
        <property type="term" value="P:embryonic morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000134">
        <property type="entry name" value="Homeobox protein MSX-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050674">
        <property type="entry name" value="Msh_Homeobox_Regulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24338">
        <property type="entry name" value="HOMEOBOX PROTEIN MSX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24338:SF10">
        <property type="entry name" value="HOMEOBOX PROTEIN MSX-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="132"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="7">
        <location>
            <begin position="134"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="47"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005010111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="259" mass="28283" checksum="1DCB2012FDD137C9" modified="2022-01-19" version="1">MASPSKAKEVFSSDEEGPAAGAEEHHKVKVSSLPFSVEALMSDKKPPKELPLAAAGSSADGATVGTSRNMLLPGHGSRDAHSPPGALTKTFDTASVKSENSEDGTSWIQEAGRYSPPPRHLSPTACTLRKHKTNRKPRTPFTTSQLLALERKFRQKQYLSIAERAEFSSSLNLTETQVKIWFQNRRAKAKRLQEAELEKLKMAAKPMLPSGFSLPFPINSPIQAASLYGTSYPFHRPVLPIPPVGLYATPVGYSMYHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T8V8</accession>
    <name>A0A8C2T8V8_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amyloid beta protein binding family A member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">APBA1</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015704571.1">
        <property type="nucleotide sequence ID" value="XM_015849085.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032297413.1">
        <property type="nucleotide sequence ID" value="XM_032441522.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032297414.1">
        <property type="nucleotide sequence ID" value="XM_032441523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T8V8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005013092.1">
        <property type="protein sequence ID" value="ENSCJPP00005008659.1"/>
        <property type="gene ID" value="ENSCJPG00005007725.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107306176"/>
    <dbReference type="KEGG" id="cjo:107306176"/>
    <dbReference type="CTD" id="320"/>
    <dbReference type="GeneTree" id="ENSGT00940000156820"/>
    <dbReference type="OrthoDB" id="5987010at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome Z"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043197">
        <property type="term" value="C:dendritic spine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048787">
        <property type="term" value="C:presynaptic active zone membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098685">
        <property type="term" value="C:Schaffer collateral - CA1 synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001540">
        <property type="term" value="F:amyloid-beta binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014051">
        <property type="term" value="P:gamma-aminobutyric acid secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014047">
        <property type="term" value="P:glutamate secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007626">
        <property type="term" value="P:locomotory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035264">
        <property type="term" value="P:multicellular organism growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099171">
        <property type="term" value="P:presynaptic modulation of chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd22578">
        <property type="entry name" value="Mint1_CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06720">
        <property type="entry name" value="PDZ1_APBA1_3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06793">
        <property type="entry name" value="PDZ2_APBA1_3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01208">
        <property type="entry name" value="PTB_X11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000044">
        <property type="entry name" value="amyloid beta A4 precursor protein-binding family A member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000007">
        <property type="entry name" value="Amyloid beta A4 protein-binding family A member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000017">
        <property type="entry name" value="Amyloid beta A4 protein-binding family A member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051230">
        <property type="entry name" value="APP-Binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12345:SF14">
        <property type="entry name" value="AMYLOID-BETA A4 PRECURSOR PROTEIN-BINDING FAMILY A MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12345">
        <property type="entry name" value="SYNTENIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PID" evidence="5">
        <location>
            <begin position="443"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="642"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="733"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="222"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="267"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="342"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="310"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="371"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="383"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005008659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="823" mass="91797" checksum="9277A2E9E8BB97DC" modified="2022-01-19" version="1">MNHLVGPPDGEVSEEPTNGAVNESVEADLEHSEVEKEQRYATHYPRHTNSSQGGLSGQEEEGMLARSASTESGFHNHTDTAEGDVIATVEDSYDTERVQENEDESAYAVQYRPESEEYTENAEAEHGEAIHNRTLPNHLHFHSIEHEEAMNAAYSGYVYTHRLFHRGEDEQYAEPYADYGLQEHVYEEIGDTPDLDAREGIQLYEREREEADNYRKEALGARLHHYDERSDGESDSPEKEAEFAPYPRMDSYEQEEDIDQIVAEVKQSMSSQSLDKAAEDMPEAEQSLEHAHAFAGGGHESNGQLPPGSRVTSGSGETVQRYSKEKRDAISLAIKDIKEAIEEVKTRTIRSPYTPDEPKEPIWVMRQDISPTRDSDDQRPLDGDSPSPDSSSPRGAESSSRQHHQDVCSTAEPSTNKESRKSLASFPTYVEVPGPCEPEDLIDGIIFAANYLGSTQLLSDKTPSKNVRMMQAQEAVSRIKMAQKLAKSRKKAPEGESQPMTEVDLFISTQRIKVLNADTQETMMDHPLRTISYIADIGNIVVLMARRRMPRSNSQDNVEASHPSQDGKRQYKMICHVFESEDAQLIAQSIGQAFSVAYQEFLRANGINPEDLSQKEYSDLLNTQEMYNDDLIHFSKSENCKDVYIEKQKGEILGVVIVESGWGSILPTVIIANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLPLSTCQSIIKGLKNQARVKLNIVRCPPVTTVLIRRPDLRYQLGFSVQNGIICSLMRGGIAERGGVRVGHRIIEINGQSVVATPHEKIVHILSNAVGEIHMKTMPAAMYRLLTAQEQPVYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T8X7</accession>
    <name>A0A8C2T8X7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Syntaxin-7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">STX7</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Early endosome membrane</location>
            <topology evidence="10">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015714060.1">
        <property type="nucleotide sequence ID" value="XM_015858574.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015714061.1">
        <property type="nucleotide sequence ID" value="XM_015858575.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T8X7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005015132.1">
        <property type="protein sequence ID" value="ENSCJPP00005010171.1"/>
        <property type="gene ID" value="ENSCJPG00005008907.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107311751"/>
    <dbReference type="KEGG" id="cjo:107311751"/>
    <dbReference type="CTD" id="8417"/>
    <dbReference type="GeneTree" id="ENSGT01000000214440"/>
    <dbReference type="OrthoDB" id="364348at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042582">
        <property type="term" value="C:azurophil granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001772">
        <property type="term" value="C:immunological synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008021">
        <property type="term" value="C:synaptic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070820">
        <property type="term" value="C:tertiary granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019869">
        <property type="term" value="F:chloride channel inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902685">
        <property type="term" value="P:positive regulation of receptor localization to synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001916">
        <property type="term" value="P:positive regulation of T cell mediated cytotoxicity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903076">
        <property type="term" value="P:regulation of protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15875">
        <property type="entry name" value="SNARE_syntaxin7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000016">
        <property type="entry name" value="Syntaxin 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.70:FF:000006">
        <property type="entry name" value="Syntaxin 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006012">
        <property type="entry name" value="Syntaxin/epimorphin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF90">
        <property type="entry name" value="SYNTAXIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14523">
        <property type="entry name" value="Syntaxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00503">
        <property type="entry name" value="SynN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00914">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="15">
        <location>
            <begin position="161"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="164"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005010171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="260" mass="29663" checksum="5EB76637834DC617" modified="2022-01-19" version="1">MSYSAGFVDPNQLAQRITSNIQKITQCSAEIQRILSQLGTPQDTHELRQQLQQKQQYTNQLAKETDKYIKEFGSLPATSEQRQKKIQKDRLVGEFTTALTNFQRLQRQAAEKEKDFVARVRASSRISSGAPEDSYKEGTLVSWDSQPQAQVQDEEITEDDLRLIEERESSIRQLESDIMDINEIFKDLGMMIHEQGDVIDSIEANVENAEVHVQQANQQLARAANYQQRSRKKMCILIGILVAGALILGIIIWFSLNKHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T9U4</accession>
    <name>A0A8C2T9U4_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Angiopoietin 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ANGPT2</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015714781.1">
        <property type="nucleotide sequence ID" value="XM_015859295.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T9U4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005013535.1">
        <property type="protein sequence ID" value="ENSCJPP00005009020.1"/>
        <property type="gene ID" value="ENSCJPG00005007988.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107312136"/>
    <dbReference type="KEGG" id="cjo:107312136"/>
    <dbReference type="CTD" id="285"/>
    <dbReference type="GeneTree" id="ENSGT00940000158430"/>
    <dbReference type="OrthoDB" id="7735366at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048018">
        <property type="term" value="F:receptor ligand activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030971">
        <property type="term" value="F:receptor tyrosine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001525">
        <property type="term" value="P:angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007596">
        <property type="term" value="P:blood coagulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016525">
        <property type="term" value="P:negative regulation of angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030195">
        <property type="term" value="P:negative regulation of blood coagulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043537">
        <property type="term" value="P:negative regulation of blood vessel endothelial cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010812">
        <property type="term" value="P:negative regulation of cell-substrate adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050928">
        <property type="term" value="P:negative regulation of positive chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050820">
        <property type="term" value="P:positive regulation of coagulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048014">
        <property type="term" value="P:Tie signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.530.10:FF:000001">
        <property type="entry name" value="angiopoietin-2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.215.10:FF:000001">
        <property type="entry name" value="Tenascin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.530.10">
        <property type="entry name" value="Gamma-fibrinogen Carboxyl Terminal Fragment, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057439">
        <property type="entry name" value="ANG-1/2/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037579">
        <property type="entry name" value="FIB_ANG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020837">
        <property type="entry name" value="Fibrinogen_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47221">
        <property type="entry name" value="FIBRINOGEN ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47221:SF6">
        <property type="entry name" value="FIBRINOGEN ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25443">
        <property type="entry name" value="ANG-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00514">
        <property type="entry name" value="FIBRINOGEN_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0037">Angiogenesis</keyword>
    <keyword evidence="5 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034170582" evidence="9">
        <location>
            <begin position="17"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="10">
        <location>
            <begin position="272"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="164"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005009020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="493" mass="56352" checksum="D37ECE3AB7C646D7" modified="2022-01-19" version="1">MRLSVYFTWGCSIVLAAGYNAFGKGAEPAGKKQYQVQHGPCSYTFLLPEADSCRPPYVPNAVQRDAPLDYDDSVQRLQLLENIMENNTQWLLKLENYIQDSMKKEMVEIQQTAVQNQTAVMIEIGTNLLNQTAEQTRKLTDVEAQVLNQTTRLELQLLEHSLSTNKLERQISVQTNEITKLQEKNSFLEKRVLEMEDKHTLQLKSIKDEKDQLQVLVARQNSIIEELEKQLVTATVNNSVLQKQQHDLMETVHNLLTMISTPNSAKNNFIAKEEQISFKDCAEAFKSGLTTSGIYTLTFPNSAQEKKAYCDMESSGGGWTVLQRREDGSVDFHRTWKEYKIGFGDPAGEYWLGNEFVSQLTNQKRYVLKIILKDWEGNEAYTLYDQFYLANEEQKYRIHLKGLTGTAGKISSISQPGNDFSTKDADNDKCICKCSQMLTGGWWFDACGPSNLNGMYYPLRQNNNKFNGIKWYYWKGSGYSLKATTMMIRPADF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TAC9</accession>
    <name>A0A8C2TAC9_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Selenoprotein O</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">SELENOO</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SELO family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TAC9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005014541.1">
        <property type="protein sequence ID" value="ENSCJPP00005009774.1"/>
        <property type="gene ID" value="ENSCJPG00005008556.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000005508"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070733">
        <property type="term" value="F:AMPylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00692">
        <property type="entry name" value="SelO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003846">
        <property type="entry name" value="SelO"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000658">
        <property type="entry name" value="PRK00029.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12153:SF15">
        <property type="entry name" value="PROTEIN ADENYLYLTRANSFERASE SELO, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12153">
        <property type="entry name" value="SELENOPROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02696">
        <property type="entry name" value="SelO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005009774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="667" mass="74608" checksum="8A9100C59B768074" modified="2022-01-19" version="1">MAAALRRRSEPLLRVLVAAMQRAAGSPSRPGSPELGSGVGWLRALRFDNLALRSLPVDPSEDHAPRAVPGACFARVRPTPLSDPRLVAMSPPAMALLGLEAEREAEAEREAEAAMYFSGNRLLPGSEPAAHCYCGHQFGSFAGQLGDGAAMYLGEVLGPSGARWELQLKGAGITPFSRQADGRKVLRSSIREFLCSEAMFHLGIPTTRAGTCVTSDSEVVRDIFYDGNPKKERCTVVLRIAPTFIRFGSFEIFKPPDEYTGRKGPSVNRNDIRVQMLDYVIGTFYPEIQEAHADNSVQRNAAFFKEITKRTARLVAEWQCVGFCHGVLNTDNMSIVGLTIDYGPFGFMDRYDPEHICNGSDNTGRYAYNKQPEICKWNLGKLAEALVPELPLEISELILEEEYDAEFEKHYLQKMRKKLGLIQLELEEDSKLVSELLETMHLTGGDFTNIFHLLSSFSVDTDPSRLEDFLGKLMSQCASVEELRVAFKPQMDPRQLSMMLMLAQSNPQLFALIGTKANINKELERIEQFSKLQQLTAADLLSRNKRHWTEWLEKYRARLHKEVESISDVDAWNTERVKVMNSSNPKYILRNYIAQNAIEAAENGDFSEVRNVLKLLENPFQETEESSETDTKEEEATAAAAACAQATRSRLPYCSKPPLWASELCVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TAM8</accession>
    <name>A0A8C2TAM8_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histone H3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TAM8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005014438.1">
        <property type="protein sequence ID" value="ENSCJPP00005009683.1"/>
        <property type="gene ID" value="ENSCJPG00005008480.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286903"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00322">
        <property type="entry name" value="HISTONE_H3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005009683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="83" mass="8924" checksum="CE0F64B7DFBCC598" modified="2022-01-19" version="1">MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPSPLKSQYCGSTMRCIFSVLCGKVCISHPYPLKSVKLGYTPVFYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TAT4</accession>
    <name>A0A8C2TAT4_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">T-box-containing protein TBX6L</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC107321317</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_032303772.1">
        <property type="nucleotide sequence ID" value="XM_032447881.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032303773.1">
        <property type="nucleotide sequence ID" value="XM_032447882.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032303774.1">
        <property type="nucleotide sequence ID" value="XM_032447883.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032303775.1">
        <property type="nucleotide sequence ID" value="XM_032447884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TAT4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005015231.1">
        <property type="protein sequence ID" value="ENSCJPP00005010250.1"/>
        <property type="gene ID" value="ENSCJPG00005008963.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107321317"/>
    <dbReference type="KEGG" id="cjo:107321317"/>
    <dbReference type="GeneTree" id="ENSGT00940000164254"/>
    <dbReference type="OrthoDB" id="7442607at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001708">
        <property type="term" value="P:cell fate specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20197">
        <property type="entry name" value="T-box_VegT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.820:FF:000007">
        <property type="entry name" value="T-box transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.820">
        <property type="entry name" value="Transcription factor, T-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046360">
        <property type="entry name" value="T-box_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036960">
        <property type="entry name" value="T-box_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001699">
        <property type="entry name" value="TF_T-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018186">
        <property type="entry name" value="TF_T-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11267:SF200">
        <property type="entry name" value="MGA, MAX DIMERIZATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11267">
        <property type="entry name" value="T-BOX PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00907">
        <property type="entry name" value="T-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00937">
        <property type="entry name" value="TBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00425">
        <property type="entry name" value="TBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01283">
        <property type="entry name" value="TBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01264">
        <property type="entry name" value="TBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50252">
        <property type="entry name" value="TBOX_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="T-box" evidence="9">
        <location>
            <begin position="31"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="203"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="206"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="234"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005010250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="452" mass="51254" checksum="5EC8E61ED96F53E3" modified="2022-01-19" version="1">MQVLPDIKAPCEALASPSLEPYPQSSITVTLEDMGLWMKFHQIGTEMIITKSGRRMFPQCKIKVSGLIPYAKYLMLVDFVPVDNFRYKWNKDQWEVAGKAEPQLPCRTYVHPDSPAPGSHWMKEPVSFQKLKLTNNTLDQHGHIILHSMHRYKPRFHIVQADDLFSVRWSIFQVFSFPETVFTSVTAYQNEQITKLKIDNNPFAKGFREHGKNTRREGRAKSQKQSPAKGQKRKLPEEKESGSEERDFEKDENVDVKEESNPVVVSSGYPFWISEQNSSLPFPAASPVPAEQREGPAREQQVPTPSYQTYRFHEAGDNQQLPSRDVAALNDFRARCHPLDLATVPEHDSKQLPEGFTNLPPLPPPLPPPQDYTGVVNMALDSVGKPGARAPMYSPYGTEQGLGQWMVPPHSQYRAMSYSAFSTDYNTQGASGHAHGTMAEWSQYPLFPYACW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TBD6</accession>
    <name>A0A8C2TBD6_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TPD52 like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TPD52L1</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TPD52 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TBD6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005015553.1">
        <property type="protein sequence ID" value="ENSCJPP00005010526.1"/>
        <property type="gene ID" value="ENSCJPG00005009156.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159202"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001235">
        <property type="term" value="P:positive regulation of apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046330">
        <property type="term" value="P:positive regulation of JNK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007327">
        <property type="entry name" value="TPD52"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19307">
        <property type="entry name" value="TUMOR PROTEIN D52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19307:SF8">
        <property type="entry name" value="TUMOR PROTEIN D53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04201">
        <property type="entry name" value="TPD52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="123"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005010526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="299" mass="33373" checksum="8AD570DA2676A093" modified="2022-01-19" version="1">MTCSQCNTNFCYRCGERYRQLRFFGDHTSNLSIFGCKYRYLPERPHLRRLVRGSVCAGKLLITPLILILGLALGAVAVVVGLFVFPIYCLCKKQRKRSRTGLLETQSLHEADEDMVTDVDFTTMISEEEKEELKAELAKLEDEISTLRQVLAAKEKHLIEIKQKLGMSLMNELKQNFSKSWHDMQTTSAYKKTHETLSHAGQKATAAISNVGTAISKKFGDMSYSIRHSISMPAMRNSPTFKSFEEKVETTVTSLKTKVGGTSHTGGSFEEVLSSTAHASAQSSLAGTRLPESEEELQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TC82</accession>
    <name>A0A8C2TC82_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP-dependent RNA helicase DHX30</fullName>
            <ecNumber evidence="4">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">DEAH box protein 30</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">DHX30</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
            <location evidence="1">Mitochondrion nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005015709.1">
        <property type="protein sequence ID" value="ENSCJPP00005010637.1"/>
        <property type="gene ID" value="ENSCJPG00005008079.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158279"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035770">
        <property type="term" value="C:ribonucleoprotein granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002151">
        <property type="term" value="F:G-quadruplex RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007417">
        <property type="term" value="P:central nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902775">
        <property type="term" value="P:mitochondrial large ribosomal subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd17976">
        <property type="entry name" value="DEXHc_DHX30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000004">
        <property type="entry name" value="ATP-dependent RNA helicase DHX30 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000016">
        <property type="entry name" value="ATP-dependent RNA helicase DHX30 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000017">
        <property type="entry name" value="ATP-dependent RNA helicase DHX30 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000414">
        <property type="entry name" value="ATP-dependent RNA helicase DHX30 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000375">
        <property type="entry name" value="Putative ATP-dependent RNA helicase DHX30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056755">
        <property type="entry name" value="DSRM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF257">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24995">
        <property type="entry name" value="DSRM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1135">Mitochondrion nucleoid</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="559"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="768"/>
            <end position="941"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005010637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1302" mass="145283" checksum="0A1874A380F1A42F" modified="2022-01-19" version="1">MARLPSQCTRDPKEADIIGSLISLGCTGPQCSSIATPRCVQGHQPSLYILALISPPPFLLLFFLHLSVLLSSPPLPLSARGRCSGDAALYPTLLPSPLGPQPAPCGSRWRRWGCCSKRRPPAALPARCASAAATGGPGGYSRDLLKEFPQPKNLLNSVIGRALGISHARDKLVYIHTNGPRKKKVTLHIKWPKNVEVEGYGTKKIDAERQAAAAACQLFKGWGLLGPRNELFDAAKYRLLADQLGCPDERWCSEGKWRSKSGPSLADLSTCWRRMEPDDPIQPMEQGRMPKAMRREELEEGELEEGELEEGELEEEAIDVSDYLPMAHQDARTLGRDPSRGGSSIEMTDDNTAIRALTQFPLPKNLLAQVIQIATSSSTVKEYMQFRTVGTKTKICKLTLRWPCPMTFAAKGRRKVEAENKAAALACQKLKSLGLVDKNNNPLSHAMYNMTSLRELGENQRKPCHIKVPEATLRKIENYLNHYPVDIRESRPRLADDMMNLSKESGAISDAITGKTYIPMLEAEEVRLSQNLLALWKRRGSSWQESHPLPVDPHKDTILSAIEQNPVVVIAGDTGCGKTTRIPQLLLEHYILEGRGARCNVVITQPRRISAISVAQRVAQELGPNMRKNVGYQVRLESKPPARGGALLFCTVGILLRKLQGNPSLEGVSHVVVDEVHERDVNTDFLLILLKGIQKLNPDLRLVLMSATGDNQRFSHYFGDCPVVKVPGFMYPVKEYYLEEILAKLGRHRHRHYEIKQSDDECVLDLDLITDLVLQIDAHGEPGGILCFLPGWQEIKGVQQRLLEMLGSQNSRYLVLPVHSNIPMMDQQNIFQRPPPGVRKIVLATNIAETSITINDIVHVVDSGTHKEERYDLKTKVSCLETVWVSKSNVVQRRGRAGRCQSGFAYHLFPRSRLDKMPTYQVPEILRTPLENLVVQAKIHMPEKTAVEFLSKALDSPDIKAVDEAVILLQEIGVLDQREALTTLGKRLAQISTDPRLAKAIVLASIYRCLHPLLVIVSCLTRDPFSSSLQNRAEVDKAKAVLSRESGSDHLAFVRAVAGWEEVLRRRDSRARDNYLQDYYLYGPSLRFINGLVKQFSENLYEAFLVSSPSDCTMPSSVCNQYSEEEELVKGVLMAGLYPNLIQVRQGKVTRQGKFKPNSYAYRTKAGTVLLHKSTINREASKLYSRWLTYFMAVKSNGGVFVRDSSQVHPLAVLLMTDTDIHVRDDGWRATVSLTDSDLLVLEGDSYTIRLLRDFRVSLSKMVETCLCYEMAAIPGDLHHQHSQLLDILVDLLKGPPGSFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TCP3</accession>
    <name>A0A8C2TCP3_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450 4B1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC107317627</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TCP3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005017145.1">
        <property type="protein sequence ID" value="ENSCJPP00005011767.1"/>
        <property type="gene ID" value="ENSCJPG00005010074.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161527"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20678">
        <property type="entry name" value="CYP4B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000005">
        <property type="entry name" value="cytochrome P450 4F22 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF201">
        <property type="entry name" value="CYTOCHROME P450, FAMILY 4, SUBFAMILY B, POLYPEPTIDE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="533"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005011767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="586" mass="66763" checksum="C8AA53E684374488" modified="2022-01-19" version="1">MRLPGSSGLFPSSFSAQHRPRSSSRSARAPTPGTAGCSDRNKRCRDSAAARTADPAPPPYIDRRGGGGIRASVPAGTARMKASWFGVDVARVLHLAAVFCLTCVLLKAIQLYHRRRELMRAMSAFPGHPTHWLLGHVQEFLKEEELLEKAEAWALKYNHAHPVWFGGFSAFLVVSNPEYAKALFARGDPKDNLSYKHLIPWIGNGLLILHGPKWHQHRKLLTPGFHYDVLKPYVALMAESTNVMLDKWEKLITNGKPVELFEHVSLMTLDSIMKCAFSYHSNCQTDRQNTYIQAVYDLCHLVHQRLRIFPYHNDFIYWLSPHGYRFRKVCQLAHDHTDKVIKERKESLTDEQEFEKIKKKRHLDFLDILLCAKDENGAGLSDEDLRAEVDTFMFEGHDTTASGISWVLYCLASHPEHQTRCREEIRDILGSRDTIQWEDLGKMTYSTMCIKESLRLYPPVPGVSRQLSKPITFHDGRTLPEGTVTAISIYLIHRNPSVWKDPLVFDPLRFSPENVSGRHSHAFLPFAAGMRNCIGQQFAMIEMKVALALTLLRFELSPDLTNPPCKIPRIILRSKNGIYLYLKKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TCR5</accession>
    <name>A0A8C2TCR5_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">TSPAN1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Participates thereby in diverse biological functions such as cell signal transduction, adhesion, migration and protein trafficking. Regulates neuronal differentiation in response to NGF by facilitating NGF-mediated activation of NTRK1/TRKA receptor tyrosine kinase and subsequent downstream signaling pathways. Plays a role in the inhibition of TNFalpha-induced apoptosis. Mechanistically, inhibits the NF-kappa-B signaling pathway by blocking phosphorylation of CHUK. Also promotes the stability of the thiamine transporter 1/SLC19A2 in intestinal epithelial cells leading to an increase of thiamine uptake process.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Interacts with SLC19A2. Interacts with NTRK1/TRKA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the tetraspanin (TM4SF) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015726030.1">
        <property type="nucleotide sequence ID" value="XM_015870544.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TCR5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005017119.1">
        <property type="protein sequence ID" value="ENSCJPP00005011745.1"/>
        <property type="gene ID" value="ENSCJPG00005010057.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107317630"/>
    <dbReference type="KEGG" id="cjo:107317630"/>
    <dbReference type="CTD" id="10103"/>
    <dbReference type="GeneTree" id="ENSGT00940000158851"/>
    <dbReference type="OrthoDB" id="6134317at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030054">
        <property type="term" value="C:cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031982">
        <property type="term" value="C:vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd03156">
        <property type="entry name" value="uroplakin_I_like_LEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1450.10:FF:000020">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000301">
        <property type="entry name" value="Tetraspanin_animals"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018503">
        <property type="entry name" value="Tetraspanin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF216">
        <property type="entry name" value="TETRASPANIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002419">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00421">
        <property type="entry name" value="TM4_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0458">Lysosome</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="209"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005011745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="238" mass="26049" checksum="163D39A1BB370621" modified="2022-01-19" version="1">MGCFTFIKVMMILFNLAIFLGGGTLLGIGIWVSVDGKSFMDLFGTLSSSVMQVVNVSYFLIVIGAILVVIGFLGCCGAQKESKCLLMMFFSVVLIIFIAEIAAAVVVLVYTGFAETFLTQLVTPVLKEKYGEDDVVTQIWNVTMNEFHCCGLNNYTDFQDSRWYLDHNNTFPIPCCMSVEPCDAQLAAKKNVSGCFDQILDEIRTNADVVGGVAAGIAALEVAAMVVSMYLYCYLDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TE46</accession>
    <name>A0A8C2TE46_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Coiled-coil domain containing 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CCDC13</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015708493.1">
        <property type="nucleotide sequence ID" value="XM_015853007.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015708494.1">
        <property type="nucleotide sequence ID" value="XM_015853008.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015708495.1">
        <property type="nucleotide sequence ID" value="XM_015853009.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032298699.1">
        <property type="nucleotide sequence ID" value="XM_032442808.1"/>
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        <property type="nucleotide sequence ID" value="XM_032442809.1"/>
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        <property type="protein sequence ID" value="ENSCJPP00005012382.1"/>
        <property type="gene ID" value="ENSCJPG00005010525.1"/>
    </dbReference>
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        <property type="component" value="Chromosome 2"/>
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        <property type="term" value="C:centriolar satellite"/>
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        <property type="term" value="P:cytoplasmic microtubule organization"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:DNA damage response"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038929">
        <property type="entry name" value="CCDC13"/>
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    <dbReference type="PANTHER" id="PTHR31935">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31935:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="26"/>
            <end position="58"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="608"/>
            <end position="630"/>
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        <location>
            <begin position="143"/>
            <end position="184"/>
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            <begin position="309"/>
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        <location>
            <begin position="429"/>
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            <begin position="657"/>
            <end position="695"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="612"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005012382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="715" mass="81228" checksum="19C12D09CA63EC14" modified="2022-01-19" version="1">MESDVNGNEHFKSQFKALQVQQQRRLQNLMERKKEKQNSQKSNSGNGKETFNIPTDLNLFETEQPVTEDESKRSLEVENEQLQDQLREVRDENCRLYKLVTEKDFEIKQLQKKLQESRLVLSGTSGLAGDVAATKIVELAKKNREIIAETESEKAKVKQLNNKVKELERELQTAVEKIHFLSGNDGIKQSALKRTEENLAEIPEVKALQEKLTTANFKVLEYRNQLQSAKQELKMTQKLLANEVGEDVNIQSLLTNSGSWRGRAQQILVLQSKIRELESQLGQNKSKTSLSEMDEELLALTDPRKLSAQEKNLLKIRSLEKERKEALEKLTVEHDALQKNHEEVKKILDATKARNKVLCGEVKTLKGQIATLLEKGKHDDELIDALLSQQKQMQEILKHMSQQDEKNKESQQLLGQHLNNEAQKQNCLIEQLRQMVAEREAKVKELEEEIGQLALQKKSAHQGDNSGAVVTPPSAHSEDLYLSGLKPLTSAGDQVGRIASARTVSRMGHTLIESAATKPSLLNSNITPGRLAGNDSLDFKVLQTQITEHKALCQAAEVERDRLLELVTVLQKRIEEGSDKVLETEKRLQEERRRCVILEQQLEKLQMEPGRITSTQKPPLRSKTGQSAGQSRLTLNMSDRKELSAAQLSKLPLESQIEELSTRLVIQLDENEALKAALEATVRKKEEDFKLYQDTMEQVKDIFLQAIRQQKQEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TEE7</accession>
    <name>A0A8C2TEE7_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ARF like GTPase 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ARL9</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TEE7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005018111.1">
        <property type="protein sequence ID" value="ENSCJPP00005012502.1"/>
        <property type="gene ID" value="ENSCJPG00005010630.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159397"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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        <property type="entry name" value="Arf-like_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
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    <dbReference type="PANTHER" id="PTHR46724:SF2">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46724">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SAR1GTPBP"/>
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        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SAR"/>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="23"/>
            <end position="30"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="70"/>
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        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="124"/>
            <end position="127"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005012502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="185" mass="20152" checksum="F3306C61374FC12B" modified="2022-01-19" version="1">PCRPGCSQPHPAWPGTRQILVLGLDGAGKSSVLHSLATNQVKRSVAPTEGFNAVCINSGESQMEFLEIGGSESLRTYWKMYLPKVLLLIYVVDSADRARLPVAKELLHQLIQNNSTLPVVVLANKQDLEGAFCITDIYDALALSDTGDKRKMFLLGTHVAEDGSEISSSMKDAKELIAQLVLEMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TET0</accession>
    <name>A0A8C2TET0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pleckstrin homology-like domain family A member 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Imprinted in placenta and liver protein</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Plays a role in regulating placenta growth. May act via its PH domain that competes with other PH domain-containing proteins, thereby preventing their binding to membrane lipids.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PHLDA2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TET0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005018303.1">
        <property type="protein sequence ID" value="ENSCJPP00005012671.1"/>
        <property type="gene ID" value="ENSCJPG00005010757.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00440000039564"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901981">
        <property type="term" value="F:phosphatidylinositol phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000270">
        <property type="entry name" value="Pleckstrin homology-like domain family A member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042832">
        <property type="entry name" value="PHLA1/2/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15478:SF8">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY-LIKE DOMAIN FAMILY A MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15478">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY-LIKE DOMAIN, PQ-RICH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="10">
        <location>
            <begin position="7"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="119"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005012671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="160" mass="18413" checksum="0FDA4EB8552833BB" modified="2022-01-19" version="1">MKMQAEVIREGELEKRSDSLFQLWKKKLVVLTKDSLSLFPDGHKRAKGKELGFGSILKVDCVERTGKYIYFTIVTKDRKEIDFRCPDQSCWNASITMALIDFQNKRAIQDFKSRQEMEQAAGTQERRLARAKKASSPLLSSPHPQPGMPVAEYYCCRLYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TFW8</accession>
    <name>A0A8C2TFW8_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">USP31</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="RefSeq" id="XP_015732439.1">
        <property type="nucleotide sequence ID" value="XM_015876953.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005017463.1">
        <property type="protein sequence ID" value="ENSCJPP00005012006.1"/>
        <property type="gene ID" value="ENSCJPG00005010245.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107320757"/>
    <dbReference type="KEGG" id="cjo:107320757"/>
    <dbReference type="CTD" id="57478"/>
    <dbReference type="GeneTree" id="ENSGT00940000156355"/>
    <dbReference type="OrthoDB" id="292964at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02674">
        <property type="entry name" value="Peptidase_C19R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000046">
        <property type="entry name" value="ubiquitin carboxyl-terminal hydrolase 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000048">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF44">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="8">
        <location>
            <begin position="121"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="72"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="801"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="935"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="39"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="942"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="976"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1029"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1091"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1114"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1124"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1138"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1160"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1191"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1210"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1227"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1279"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1315"/>
            <end position="1328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005012006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1328" mass="144706" checksum="037C3EB65632C037" modified="2022-01-19" version="1">MSRVSGPGPAGSAKEKRSFSKRLFRGRAAGGGAAPSPAPSAASSSSSPSAAPGRSLGGFMSRVLKTLSTLSHYSSEPEPRGPQAPRLPPPRAAGGLSSCLPPGRPEPPAPERGSEAVPGVAGLRNHGNTCFMNAILQCLSNTELFAEFLALEQFRGPAEPGPPPPAPGEVTEQLAQLVRALWTLEYTPQHSRDFKNIVSKNAMQYRGNAQHDAQEFLLWLLDRVHEDLNNAVNYSGMPPLKPPLEDDVLLEGPAFPISSTFVQELFQAQYRSSLTCPHCQKQSNTFDPFLCISLPIPLPHTRPLYVTVVYQGKCSHCMRIGVAVPIAGTVARLREAVSSETKIPTEQIVLTEMYYDGFHRSFCDTDDLDTIHESDCIFAFETPEIFRPEGILSQRGIHVNNNLNNLKYSTEQSRTVLYSQGTVVSGKLEQSSTRQGASDKIVLLVCNRACTGQQSRRFGLPFVLHLEKTIAWDILQKEILEKMQYFLRPAACLQVCPFSLRVVSVVGITYLLPQEERPLCHPTVERALKSCGQGGTAHVKLVVEWDKETKDFLFVNTEDEYIPDSESVRQQRELHHQPQTCTLSQCFQLYTKEEQLAPDDAWRCPHCKQLQQGSITLSLWTLPDVLIIHLKRFRQEGDRRMKLQNMVKFPLSGLDMTPHVVKRSQSSWSLPSHWSPWRRPYGLGRDPEDYIYDLYAVCNHHGTMQGGHYTAYCKNSVDGQWYCFDDSDVQQLSENEVCKQTAYILFYQRRTAIPSWSANSSVAGSTSSSLCEHWVSRLPGSKQPSIASAASSRRTSLASLSESVELTGERSEDDGGFSTRPFVRSVQRQSLSSRSSVTSPLAVSENGVRPSWSLSAKLQMRSNSPSRFSGDSPVHTSASTLEKIGEAADDKVSTSCFGSLRNLSSSYLEPCDGGRREHKAARRAPLAVMEGAFREEPVVRTSSSDLSDGLGKSSEQPDRNHPALDPFDNNNQIAFVDQSDSVDSSPVKEVKAPSGTGLAPEKAEGTPKKAHSSKGASEGDRSLRKGRTVLSTQESKVSRSSPPPLKSSQKVSRSRSKTDASRAAGRHGSPAPTQARKDHSTKSAEAAVPLTQQKQKSGSSPSSTAAKKATSGSLTKGSSAGKSRTSERSLSREGSKVSLGSDKTSVTSSSRTSSPRISHSRSDSRAVDSKHMRSSSMANLRSPNVGMRSGLKRDSKSEEKGLSFFKSALRQKETRRSADLGKTTMLSKKAAGGSSKSASKNVLEDKSEKGGVPPASQTNANVTAKEKLVPKDAAPNKHSLLSSRKSKSSLLDPGARSPPSSGKQAADKPLKRLPSSMQVSVRPSMEPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TII3</accession>
    <name>A0A8C2TII3_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">WD repeat-containing protein 48</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">USP1-associated factor 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">WDR48</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Late endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat WDR48 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TII3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005018663.1">
        <property type="protein sequence ID" value="ENSCJPP00005012944.1"/>
        <property type="gene ID" value="ENSCJPG00005010964.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00920000149157"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035800">
        <property type="term" value="F:deubiquitinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007259">
        <property type="term" value="P:cell surface receptor signaling pathway via JAK-STAT"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048568">
        <property type="term" value="P:embryonic organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048872">
        <property type="term" value="P:homeostasis of number of cells"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035264">
        <property type="term" value="P:multicellular organism growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905168">
        <property type="term" value="P:positive regulation of double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050679">
        <property type="term" value="P:positive regulation of epithelial cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046427">
        <property type="term" value="P:positive regulation of receptor signaling pathway via JAK-STAT"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902525">
        <property type="term" value="P:regulation of protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072520">
        <property type="term" value="P:seminiferous tubule development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007338">
        <property type="term" value="P:single fertilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048705">
        <property type="term" value="P:skeletal system morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043588">
        <property type="term" value="P:skin development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd17041">
        <property type="entry name" value="Ubl_WDR48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000054">
        <property type="entry name" value="Putative WD repeat-containing protein 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:002031">
        <property type="entry name" value="WD repeat domain 48b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051246">
        <property type="entry name" value="WDR48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021772">
        <property type="entry name" value="WDR48/Bun107"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19862">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19862:SF14">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11816">
        <property type="entry name" value="DUF3337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0967">Endosome</keyword>
    <keyword evidence="15" id="KW-0458">Lysosome</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8 18" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="18">
        <location>
            <begin position="26"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="18">
        <location>
            <begin position="71"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="18">
        <location>
            <begin position="113"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="18">
        <location>
            <begin position="180"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="18">
        <location>
            <begin position="222"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="624"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="626"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
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            <dbReference type="ARBA" id="ARBA00022753"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023125"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
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            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005012944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="694" mass="77936" checksum="EC920782547E9B53" modified="2022-01-19" version="1">MAAHHRQNTAGRRKVQVSYVIRDEVEKYNRNGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTASNNTVTIVLGKGEGREAGQVVLSSSLSGNKDSIYSLAMNQMGTVIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVNEAFTHVYSGGRDRKIYCTDLRNPDIRVLICEEKAPVLKMELDRSADPPPAIWVATTKSSVNKWTLKGIHNFRASGDYDNDCTNPIPPLCTQPDQVIKGGASIIQCHILNDKRHILTKDTNNNVAYWDVLKACKVEDLGKVDFEEEIKKRFKMVYVPNWFSVDLKTGMLTITLDESDCFAAWVSAKDAGFSSPDGSDPKLNLGGLLLQALLEYWPRTHINPMDEEENEINHTVNGEQENRVQKGNGYFQVPPHTPVIFGEAGGRTLFRLLCRDSGGETESMLLNETVPQWVIDITVDKNMPKFNKIPFYLQPHSSSGAKTLKKDRLSASDMLQVRKVMEHVYEKIINLDNESQTTSSSNNEKAGEQEKEEDIAVLAEEKIELLCQDQVLDPNMDLRTVKHFIWKSGGDLTLHYRQKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TJE7</accession>
    <name>A0A8C2TJE7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Heterochromatin protein 1-binding protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">HP1BP3</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TJE7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005019250.1">
        <property type="protein sequence ID" value="ENSCJPP00005013388.1"/>
        <property type="gene ID" value="ENSCJPG00005011270.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155314"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071456">
        <property type="term" value="P:cellular response to hypoxia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070828">
        <property type="term" value="P:heterochromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042127">
        <property type="term" value="P:regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097298">
        <property type="term" value="P:regulation of nucleus size"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00073">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000228">
        <property type="entry name" value="heterochromatin protein 1-binding protein 3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000276">
        <property type="entry name" value="heterochromatin protein 1-binding protein 3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005818">
        <property type="entry name" value="Histone_H1/H5_H15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15832:SF1">
        <property type="entry name" value="HETEROCHROMATIN PROTEIN 1-BINDING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15832">
        <property type="entry name" value="SHC (SRC HOMOLOGY DOMAIN C-TERMINAL) ADAPTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00538">
        <property type="entry name" value="Linker_histone"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00526">
        <property type="entry name" value="H15"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51504">
        <property type="entry name" value="H15"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="H15" evidence="9">
        <location>
            <begin position="159"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="H15" evidence="9">
        <location>
            <begin position="257"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="H15" evidence="9">
        <location>
            <begin position="340"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="427"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="97"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="430"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="480"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="516"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="549"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005013388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="559" mass="61732" checksum="278A978A8C97BA65" modified="2022-01-19" version="1">MATGLSEAEPVHHKALPLLTGTQLIHTDKLSEKAEDDTMPIRRSVNSSSRETPPKSKSAEGGEEVKADAEATSEESASAGEEQENETLPAAAPSEAEQPKEPENEEKGETKSSEETKKDEKDQSKEKEKKVKKTIPAWATLSASQLARAQKQTQMAATSRPKMDAILTEAIKACFQKSGASVVAIRKYIIHKYPSLELERRGYLLKQALKRELERGIIRQVKGKGASGSFVVVSNAGKTVQKARDRKKSTSVSTPEQQVKLEDILPLAFTRLCEPKEASYSLIKKYVSQYYPKLKVDIRPQLLKNALQRAVEKGQLEQITGKGASGTFQLKKSGEKPLLGGTLMEDAILSAIAAMNEPKTCSTTALKKYILENHPGTNSNFQVHLLKRTLQRCEKNGWLEQISGKGFSGTFQLCFPYYPSPEVLYPEKQQDEDSEESDEEEEEESEGEEESEEESEEEEPPPKKRMQKRPPPESRSRAPPMKRRESKPKPRKTPAARRGKAKPPPKVKTPARKAKPAAPAIKKPSGGSSSKKPAASGRKEVKPSAKGKSAMRKSLRAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TM94</accession>
    <name>A0A8C2TM94_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Nuclear receptor subfamily 1 group H member 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">NR1H3</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the nuclear hormone receptor family. NR1 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015719791.1">
        <property type="nucleotide sequence ID" value="XM_015864305.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015719792.1">
        <property type="nucleotide sequence ID" value="XM_015864306.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015719793.1">
        <property type="nucleotide sequence ID" value="XM_015864307.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TM94"/>
    <dbReference type="SMR" id="A0A8C2TM94"/>
    <dbReference type="Ensembl" id="ENSCJPT00005020496.1">
        <property type="protein sequence ID" value="ENSCJPP00005014391.1"/>
        <property type="gene ID" value="ENSCJPG00005012023.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107314747"/>
    <dbReference type="KEGG" id="cjo:107314747"/>
    <dbReference type="CTD" id="10062"/>
    <dbReference type="GeneTree" id="ENSGT00940000159068"/>
    <dbReference type="OrthoDB" id="5837785at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004879">
        <property type="term" value="F:nuclear receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032810">
        <property type="term" value="F:sterol response element binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043277">
        <property type="term" value="P:apoptotic cell clearance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071222">
        <property type="term" value="P:cellular response to lipopolysaccharide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042632">
        <property type="term" value="P:cholesterol homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042789">
        <property type="term" value="P:mRNA transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010887">
        <property type="term" value="P:negative regulation of cholesterol storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120163">
        <property type="term" value="P:negative regulation of cold-induced thermogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050728">
        <property type="term" value="P:negative regulation of inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032369">
        <property type="term" value="P:negative regulation of lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043031">
        <property type="term" value="P:negative regulation of macrophage activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090188">
        <property type="term" value="P:negative regulation of pancreatic juice secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048550">
        <property type="term" value="P:negative regulation of pinocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045861">
        <property type="term" value="P:negative regulation of proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903573">
        <property type="term" value="P:negative regulation of response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090341">
        <property type="term" value="P:negative regulation of secretion of lysosomal enzymes"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036151">
        <property type="term" value="P:phosphatidylcholine acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010875">
        <property type="term" value="P:positive regulation of cholesterol efflux"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045723">
        <property type="term" value="P:positive regulation of fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034145">
        <property type="term" value="P:positive regulation of toll-like receptor 4 signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010867">
        <property type="term" value="P:positive regulation of triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032570">
        <property type="term" value="P:response to progesterone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070328">
        <property type="term" value="P:triglyceride homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd07160">
        <property type="entry name" value="NR_DBD_LXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06954">
        <property type="entry name" value="NR_LBD_LXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.565.10:FF:000014">
        <property type="entry name" value="Oxysterols receptor LXR-alpha isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000017">
        <property type="entry name" value="Oxysterols receptor LXR-alpha isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023257">
        <property type="entry name" value="Liver_X_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050234">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082:SF259">
        <property type="entry name" value="OXYSTEROLS RECEPTOR LXR-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02034">
        <property type="entry name" value="LIVERXRECPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="9 14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="8 14" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="6 14" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="16">
        <location>
            <begin position="57"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="17">
        <location>
            <begin position="171"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005014391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="409" mass="47056" checksum="156C9FAB92A46587" modified="2022-01-19" version="1">MGPTQLSTQDHGKRVASVFEMEEEGLSLFSGSENPPKHAENPPLKRKKGPAPKMLGNEVCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAQYVCKNGGKCEMDMYMRRKCQECRLRKCQEAGMREQYVLSEEQIRLKKLKKQEDDQARTVVVRPNPPQPPSPSHQLTPEQLNMIEKLVAAQQQCNQRSFTDRLKVTPWPQVPDPNNREARQQRFAHFTELAIISVQEIVDFAKQLPGFRELTREDQIALLKTSTIEVMLLETSRRYNPEIESITFLKDLSYNRDDFAKAGLQFEFINPIFEFSKGMNELQLNDAEYALLIAINIFSADRPNVQDQSLVERLQHTYVEALHSYICINRPNDHLMFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TP19</accession>
    <name>A0A8C2TP19_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13">U6 snRNA-associated Sm-like protein LSm8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">LSM8</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the precatalytic spliceosome (spliceosome B complex). Component of the U4/U6-U5 tri-snRNP complex, a building block of the precatalytic spliceosome (spliceosome B complex). The U4/U6-U5 tri-snRNP complex is composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8 form a heptameric, ring-shaped subcomplex (the LSM2-8 complex) that is part of the U4/U6-U5 tri-snRNP complex and the precatalytic spliceosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TP19"/>
    <dbReference type="Ensembl" id="ENSCJPT00005020726.1">
        <property type="protein sequence ID" value="ENSCJPP00005014578.1"/>
        <property type="gene ID" value="ENSCJPG00005012150.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00730000111212"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01727">
        <property type="entry name" value="LSm8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000022">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034103">
        <property type="entry name" value="Lsm8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044642">
        <property type="entry name" value="PTHR15588"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588">
        <property type="entry name" value="LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588:SF9">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3 13" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 13" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 13" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="14">
        <location>
            <begin position="92"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00056431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00063389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00067760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005014578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="188" mass="19927" checksum="7EC1F2F53EB3F594" modified="2022-01-19" version="1">MLKAAYSQHLGFCSMRTRNTTRGHDFPLLDKHLNHSFTALGTSCSPLLPLKPSPALVLGWCGCSDGRASSERDGSGAGNGVTAVRRSAGAAAMTSALENYINRTVAVITSDGRMIVGTLKGFDQTINLILDESHERVFSSSQGVEQVVLGLYIVRGDNVAVIGEIDEETDSALDLGNIRAEPLGSVVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TPV2</accession>
    <name>A0A8C2TPV2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DIS3-like exonuclease 2</fullName>
            <ecNumber evidence="12">3.1.13.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">DIS3L2</name>
        <name evidence="12" type="synonym">dis3l2</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation.</text>
    </comment>
    <comment type="function">
        <text evidence="12">3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase. Essential for correct mitosis, and negatively regulates cell proliferation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="12">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
            <location evidence="12">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">Specifically recognizes and binds polyuridylated RNAs via 3 RNA-binding regions (named U-zone 1, U-zone 2 and U-zone 3) that form an open funnel on one face of the catalytic domain, allowing RNA to navigate a path to the active site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the RNR ribonuclease family. DIS3L2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.-" evidence="12"/>
    <dbReference type="RefSeq" id="XP_015727316.1">
        <property type="nucleotide sequence ID" value="XM_015871830.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TPV2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005023438.1">
        <property type="protein sequence ID" value="ENSCJPP00005016720.1"/>
        <property type="gene ID" value="ENSCJPG00005013721.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107318233"/>
    <dbReference type="KEGG" id="cjo:107318233"/>
    <dbReference type="CTD" id="129563"/>
    <dbReference type="GeneTree" id="ENSGT00530000063106"/>
    <dbReference type="OrthoDB" id="372421at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008266">
        <property type="term" value="F:poly(U) RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010587">
        <property type="term" value="P:miRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051306">
        <property type="term" value="P:mitotic sister chromatid separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990074">
        <property type="term" value="P:polyuridylation-dependent mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019827">
        <property type="term" value="P:stem cell population maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000177">
        <property type="entry name" value="DIS3-like exonuclease 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.690:FF:000003">
        <property type="entry name" value="DIS3-like exonuclease 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.700:FF:000003">
        <property type="entry name" value="DIS3-like exonuclease 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03045">
        <property type="entry name" value="DIS3L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041505">
        <property type="entry name" value="Dis3_CSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028591">
        <property type="entry name" value="DIS3L2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041093">
        <property type="entry name" value="Dis3l2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022966">
        <property type="entry name" value="RNase_II/R_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033771">
        <property type="entry name" value="Rrp44_CSD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF9">
        <property type="entry name" value="DIS3-LIKE EXONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17877">
        <property type="entry name" value="Dis3l2_C_term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17849">
        <property type="entry name" value="OB_Dis3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17216">
        <property type="entry name" value="Rrp44_CSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01175">
        <property type="entry name" value="RIBONUCLEASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 12" id="KW-0132">Cell division</keyword>
    <keyword evidence="1 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 12" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12" id="KW-0498">Mitosis</keyword>
    <keyword evidence="3 12" id="KW-0540">Nuclease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RNB" evidence="14">
        <location>
            <begin position="658"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="74"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="177"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="250"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="284"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="322"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="670"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="679"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="12">
        <location>
            <position position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00056476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005016720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1151" mass="129726" checksum="F2BDAC42FC4E2C8D" modified="2022-01-19" version="1">MGSVSLFELKGRFWRRKVWPCYCTMDPLGHVRSAPAQGAKEGLNKPAVPQKNAYARLVQKHHSGRFRSYMNRVAQKMQQEDSTSNEHSSDLEQPPRRGLAKENLARNGLNMRSYSPVRTSHLDQPGGFENDKPQSLFNRCLHRKNVSVNSEGDLEMEEDCYVHQHGAAADLLNTSDAMGGRVSTGPRHSAALQKSSGSDEKDEDDMWRRKHKKRGRCPANADMAAGHLLTEYFSGDVLAANARRTSLLSAGQVQGAEKRGFARTRNNSESARAPQNFDRKRQLSESQTETMSNSDSRINPRQLGTPRGGSYAALPTSGDRKNRNKPAPRKKKSIFEAYMSKEDVSAGLKRGELIQGPLRINPKKYHEAFIPSPDGTRDIFIDGVVARNRALNGDIVVVRLLPREQWKVIKPDGSDKETEATHESDVPEDMLGSCVPQEAAKGNAVSPDVIIEAQFDDNDAEHGQDHLQDTLAHDIKKLSLDTAEKVKAAGIGAVHRTKQEEVPKVNDPRLLPDKFLQRTAKVVYILEKKHSRAATGFIKLLADKNSELFKKCAMFSPVDHRVPRAYVSLADCPSDFMARPEDYSNMLFICRIVDWKEDSNFASGQLAKSLGQAGEIEPETEGILTEYGVDFSDFSPEALECLPQNLPWVISPGEMAKRRDLRKECIFTIDPSTAKDLDDALSCKQLPDGNFEVGVHIADVSYFVLEETALDRVASERATSVYLVQKVIPMLPKLLCEELCSLNPMRDRLTFSVMWKVTPEGKILDEWFGRTVICSCAKLSYDHAQSMIENPGKVFSPEELPPVSPQHSVAKIQQAVLNLHRIAQHLRKQRFIDGALRLDQLKLSFTLDQDSGMPQGCYIYQYRDSNKLVEEFMLLANMAVAHQIYRSFPEQALLRRHPPPQTKLLNDLMEFCHQVGLEIDFSSAGSLHKSLNETFRADKYSEARKEVLTNMFSRPMQMAQYFCTGVLEDEILFRHYALNVPFYTHFTSPIRRYADVVVHRLLSASLGISSPIKMEKEAIQRQAEHCNDRKMASKRVQELSTDLFFAIFVRECGPLESEAMVMGVLNEAFDVLVLKFGVQKRIYCNALPLLGFHFQKVGRKPELTLMWEPERLEEESVSQEITIFTLVEVILKSDGVPLKYSALLKRPSTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TQC8</accession>
    <name>A0A8C2TQC8_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Potassium channel tetramerization domain containing 18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">KCTD18</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TQC8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005024164.1">
        <property type="protein sequence ID" value="ENSCJPP00005017317.1"/>
        <property type="gene ID" value="ENSCJPG00005014162.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000064234"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045704">
        <property type="entry name" value="KCTD18_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14499:SF4">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14499">
        <property type="entry name" value="POTASSIUM CHANNEL TETRAMERIZATION DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19321">
        <property type="entry name" value="KCTD18_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Potassium channel tetramerisation-type BTB" evidence="1">
        <location>
            <begin position="7"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="BTB/POZ" evidence="2">
        <location>
            <begin position="66"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005017317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="383" mass="42771" checksum="34A2C7333DCA9D64" modified="2022-01-19" version="1">MYMFSGACLIDRDGSLFKYLLDYLHGEVRIPEDEQIRIALQEEADYFGIPYPYSLSDHLANEMETYSLRSNVELKKALLDFCDSYDLVCTKPTVWVLHYLSTSGASCESKIIGVYATRADGTDAINKELGTKIHSKSIYRREAGNNVQYIWSYYSEAELKKMMDAFGTWEGRGVSYWRVPQELIECWTLEERSLKGSLHHMPPVHKRRLIDFSEAEDYIPCKVGPKPIRFSGPSTSTHIKVKNSASLKVAACNTSHSAVTLKRPNSGSLVLHKAASKTVSTACMSEPSNSQVLHGKQSADDEASCQMTFNISLSRKPISSRAVKLKRTPLFLVTPSQTSPVSSKTNEQDRAAVEIPTTSMVLNKKEAAMLAESIKLKSNKEDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TQG7</accession>
    <name>A0A8C2TQG7_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">YY1 associated factor 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">YAF2</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015710098.1">
        <property type="nucleotide sequence ID" value="XM_015854612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TQG7"/>
    <dbReference type="SMR" id="A0A8C2TQG7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005022916.1">
        <property type="protein sequence ID" value="ENSCJPP00005016283.1"/>
        <property type="gene ID" value="ENSCJPG00005013398.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107309647"/>
    <dbReference type="KEGG" id="cjo:107309647"/>
    <dbReference type="CTD" id="10138"/>
    <dbReference type="GeneTree" id="ENSGT00390000013995"/>
    <dbReference type="OrthoDB" id="10063208at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1060.10:FF:000009">
        <property type="entry name" value="YY1 associated factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039958">
        <property type="entry name" value="RYBP/YAF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033774">
        <property type="entry name" value="YAF2_RYBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12920">
        <property type="entry name" value="RYBP AND YAF2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12920:SF2">
        <property type="entry name" value="YY1-ASSOCIATED FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17219">
        <property type="entry name" value="YAF2_RYBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00641">
        <property type="entry name" value="Zn_ribbon_RanBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RanBP2-type" evidence="10">
        <location>
            <begin position="19"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="47"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="163"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005016283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="180" mass="19897" checksum="E99E56ED1ACD94D3" modified="2022-01-19" version="1">MGDKKSPTRPKRQPKPSSDEGYWDCSVCTFRNSAEAFKCMMCDVRKGTSTRKPRPVSQLVAQQVPQQFVPPTQSKKEKKDKVEKEKSEKETTSKKNSHKKTRPRLKNVDRSSAQHLEVTVGDLTVIITDFKEKTKSPPASSAASADQHSQSGSSSDNTERGMSRSSSPRGEASSLNGESH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TQH5</accession>
    <name>A0A8C2TQH5_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="26">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="30" type="primary">SLC6A4</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="30" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="30" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="30" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>serotonin(out) + K(+)(in) + Na(+)(out) + H(+)(in) = serotonin(in) + K(+)(out) + Na(+)(in) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:75839"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:350546"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:75840"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Focal adhesion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Neuron projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="22">Synapse</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A4 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015736264.1">
        <property type="nucleotide sequence ID" value="XM_015880778.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015736265.1">
        <property type="nucleotide sequence ID" value="XM_015880779.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015736266.1">
        <property type="nucleotide sequence ID" value="XM_015880780.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TQH5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005022354.1">
        <property type="protein sequence ID" value="ENSCJPP00005015819.1"/>
        <property type="gene ID" value="ENSCJPG00005012857.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107322596"/>
    <dbReference type="KEGG" id="cjo:107322596"/>
    <dbReference type="CTD" id="6532"/>
    <dbReference type="GeneTree" id="ENSGT00940000157855"/>
    <dbReference type="OrthoDB" id="6581954at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005326">
        <property type="term" value="F:neurotransmitter transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050998">
        <property type="term" value="F:nitric-oxide synthase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051378">
        <property type="term" value="F:serotonin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005335">
        <property type="term" value="F:serotonin:sodium:chloride symporter activity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031402">
        <property type="term" value="F:sodium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048854">
        <property type="term" value="P:brain morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048484">
        <property type="term" value="P:enteric nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046621">
        <property type="term" value="P:negative regulation of organ growth"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070527">
        <property type="term" value="P:platelet aggregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045787">
        <property type="term" value="P:positive regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090067">
        <property type="term" value="P:regulation of thalamus size"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd11513">
        <property type="entry name" value="SLC6sbd_SERT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013086">
        <property type="entry name" value="Na/ntran_symport_serotonin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037979">
        <property type="entry name" value="Na_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF105">
        <property type="entry name" value="SODIUM-DEPENDENT SEROTONIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03491">
        <property type="entry name" value="5HT_transport_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00610">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00754">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 26" id="KW-0050">Antiport</keyword>
    <keyword evidence="14" id="KW-0965">Cell junction</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="21" id="KW-0966">Cell projection</keyword>
    <keyword evidence="19 25" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0967">Endosome</keyword>
    <keyword evidence="20" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="18 28" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 24" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0532">Neurotransmitter transport</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17 24" id="KW-0915">Sodium</keyword>
    <keyword evidence="16" id="KW-0770">Synapse</keyword>
    <keyword evidence="10 26 28" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 28" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6 26" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="158"/>
            <end position="179"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="200"/>
            <end position="228"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="291"/>
            <end position="308"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="320"/>
            <end position="346"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="366"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="402"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="447"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="504"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="535"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="579"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="610"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium:neurotransmitter symporter serotonin N-terminal" evidence="29">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="27">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="141"/>
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        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="376"/>
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        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="474"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="477"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="478"/>
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        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="240"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004246"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004337"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004487"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005461"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022775"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00047692"/>
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        <source>
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    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-2"/>
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    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="RuleBase" id="RU003732"/>
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    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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        <source>
            <dbReference type="Pfam" id="PF03491"/>
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        <source>
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        <source>
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        </source>
    </evidence>
    <sequence length="670" mass="74724" checksum="A35E15E908539141" modified="2022-01-19" version="1">MEKKATSNETQPLTSKKGTSDCNEGEDCKENGLLIRNPKSALRLMEDGNKVHPGQGDKEEAAQISNGYSGVQSSVPCNGMGEVEDVQCTAPAATTTTTTTTSTTCGAEGQQQLMELEDRETWGKKIDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLIPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGFAICVIDLYVASYYNTIMAWVFYYLVSSFTTELPWTSCNNAWNTDNCTTYFSKDNVSWALHSISPAEEFYTRQVLQVHRSNGLDDLGGISWQLTLCLLLIFVIVYFSIWKGVKTSGKVVWVTATFPYIILFILLVRGATLPGAWRGVLYYLKPEWQKLLATEVWVDAAAQIFFSLGPGFGVLLAYASYNKFHNNCYQDALVTSTVNCLTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDMGPSLLFITYAEAIANMPASTFFAIIFFLMLLTLGLDSTFAGLEGVITGVLDEFPHIWSKRREFFVLGLIIVCFLGSLATLTFGGAYVVKLFEEYATGPAVLTVVFLEAVAVAWFYGITQFCNDVKEMLGFTPGWYWRLCWVAISPIFLLFVTCSFLSSPPELRLFDYNYPYWTTVVGYCIGTSSIICIPIYMAYRLIITPGTFKERILKSITPETATEIPFGDIRMNAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TQY0</accession>
    <name>A0A8C2TQY0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transducer of regulated CREB activity N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TORC family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TQY0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005024277.1">
        <property type="protein sequence ID" value="ENSCJPP00005017419.1"/>
        <property type="gene ID" value="ENSCJPG00005014219.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000010652"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008140">
        <property type="term" value="F:cAMP response element binding protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051289">
        <property type="term" value="P:protein homotetramerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024786">
        <property type="entry name" value="TORC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024783">
        <property type="entry name" value="TORC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13589">
        <property type="entry name" value="CREB-REGULATED TRANSCRIPTION COACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13589:SF6">
        <property type="entry name" value="CREB-REGULATED TRANSCRIPTION COACTIVATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12884">
        <property type="entry name" value="TORC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transducer of regulated CREB activity N-terminal" evidence="11">
        <location>
            <begin position="16"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005017419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="53" mass="5541" checksum="04EC2E742BC48593" modified="2022-01-19" version="1">GGAALAVGPAGTGSSNPRKFSEKIALQKQRQAEETAAFEEVMMEICSTRVSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TTF0</accession>
    <name>A0A8C2TTF0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pentraxin family member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC107324519</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="10">Binds 2 calcium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the pentraxin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TTF0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005025912.1">
        <property type="protein sequence ID" value="ENSCJPP00005018649.1"/>
        <property type="gene ID" value="ENSCJPG00005015177.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01100000263515"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001849">
        <property type="term" value="F:complement component C1q complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006953">
        <property type="term" value="P:acute-phase response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00152">
        <property type="entry name" value="PTX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000070">
        <property type="entry name" value="Serum amyloid P-component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030476">
        <property type="entry name" value="Pentaxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051005">
        <property type="entry name" value="Pentraxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001759">
        <property type="entry name" value="PTX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45869:SF7">
        <property type="entry name" value="C-REACTIVE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45869">
        <property type="entry name" value="C-REACTIVE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00354">
        <property type="entry name" value="Pentaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00895">
        <property type="entry name" value="PENTAXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00159">
        <property type="entry name" value="PTX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00289">
        <property type="entry name" value="PTX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51828">
        <property type="entry name" value="PTX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0011">Acute phase</keyword>
    <keyword evidence="6 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034274413" description="Pentraxin family member" evidence="10">
        <location>
            <begin position="20"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Pentraxin (PTX)" evidence="11">
        <location>
            <begin position="24"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="55"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005018649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="227" mass="25723" checksum="9C4BCED59D21C200" modified="2022-01-19" version="1">MGTAPMWLIVLSAVTAVMGQEDLYRKVFVFREDPSHAYVLLQARPEHPMLNFTVCLRSYTDLTRPHSLFSYATKAQDNEILLFKPKPGEYRFYVGGKYVTFRVPENRGEWEHVCASWESGSGIAEFWLNGRPWPRKGLQKGYEVGNEAVVMLGQEQDAYGGGFDVYNSFTGEMADVYLWDAGLSPDKMRSAYLALRLPPALLAWGRLRYEAKGDVVVKPRLREALGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TTP3</accession>
    <name>A0A8C2TTP3_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TTP3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005024064.1">
        <property type="protein sequence ID" value="ENSCJPP00005017237.1"/>
        <property type="gene ID" value="ENSCJPG00005014098.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00960000189342"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005017237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="99" mass="12295" checksum="7E42256BD25A2023" modified="2022-01-19" version="1">MTFHREFYNDEHYSPFCQEDQHGLWVLHDQRYRHPYSLHRDHHHDYNQHWSPYGYNRSHGILYGNRSLSAHGGYYGHGDFFGFGHRHPYLSHYGHRYWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TUQ1</accession>
    <name>A0A8C2TUQ1_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Four-jointed box kinase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FJX1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015719085.1">
        <property type="nucleotide sequence ID" value="XM_015863599.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TUQ1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005026288.1">
        <property type="protein sequence ID" value="ENSCJPP00005018943.1"/>
        <property type="gene ID" value="ENSCJPG00005015411.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107314405"/>
    <dbReference type="KEGG" id="cjo:107314405"/>
    <dbReference type="CTD" id="24147"/>
    <dbReference type="GeneTree" id="ENSGT00390000016768"/>
    <dbReference type="OrthoDB" id="10055077at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007267">
        <property type="term" value="P:cell-cell signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010842">
        <property type="term" value="P:retina layer formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024868">
        <property type="entry name" value="FJX1/FJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13147">
        <property type="entry name" value="FOUR-JOINTED BOX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13147:SF5">
        <property type="entry name" value="FOUR-JOINTED BOX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02072">
        <property type="entry name" value="4JOINTEDBOX1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034206356" evidence="2">
        <location>
            <begin position="26"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005018943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="386" mass="42868" checksum="BC3B7807DAC0C013" modified="2022-01-19" version="1">MERGGRAALALGLLLLLLLLGAMLALREPAPARDEARGSGGVQKTFRALLAAGREQQQQQEEEEREKDPPAAPVRRGIFWSRELEARVPPGFAAEEAAAWRAAARGARVASLERGGCGRSSNRLARLSDGSRACVRYGVSPEQIQGEALSYHLAGLLGMQQRLPPMALALVEARGRQWEPVREELRGSHWAEGAVVSLTRWVDNLTAVVAPAPWGGGRPRTLAAGELSGLPAEQLVELVQWSDLILFDYLTANFDRLASNLFSLQWDPRVMRRATSNLLRAPDGGLVFMDNEAGLVHGYRLLATWDPYNEPLLRSVCVFREGTARRLAELHRRRNAAAELRRRYRAREPLWEHLGFLSERQAELLQARVDFVHRHIAQCRAQAAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TUT9</accession>
    <name>A0A8C2TUT9_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Semaphorin 4A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">SEMA4A</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the semaphorin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TUT9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005023786.1">
        <property type="protein sequence ID" value="ENSCJPP00005017004.1"/>
        <property type="gene ID" value="ENSCJPG00005013924.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161509"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045499">
        <property type="term" value="F:chemorepellent activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030215">
        <property type="term" value="F:semaphorin receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016525">
        <property type="term" value="P:negative regulation of angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001755">
        <property type="term" value="P:neural crest cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904891">
        <property type="term" value="P:positive regulation of excitatory synapse assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905704">
        <property type="term" value="P:positive regulation of inhibitory synapse assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010594">
        <property type="term" value="P:regulation of endothelial cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071526">
        <property type="term" value="P:semaphorin-plexin signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045063">
        <property type="term" value="P:T-helper 1 cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1680.10">
        <property type="entry name" value="ligand-binding face of the semaphorins, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045791">
        <property type="entry name" value="Sema4F_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001627">
        <property type="entry name" value="Semap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036352">
        <property type="entry name" value="Semap_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027231">
        <property type="entry name" value="Semaphorin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036">
        <property type="entry name" value="SEMAPHORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036:SF15">
        <property type="entry name" value="SEMAPHORIN-4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01403">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19428">
        <property type="entry name" value="Sema4F_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00630">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103575">
        <property type="entry name" value="Plexin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101912">
        <property type="entry name" value="Sema domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51004">
        <property type="entry name" value="SEMA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="624"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="domain" description="Sema" evidence="6">
        <location>
            <begin position="56"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Sema" evidence="6">
        <location>
            <begin position="323"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005017004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="690" mass="74730" checksum="9E9446B74CCD9059" modified="2022-01-19" version="1">MELSPTFTFGIPSPCGSAAVWGTDGELPPPPCPADPTDPTAPTAPRPHQPPTPQTRWTPTTPPHRPHSDPRRPVRSFSSPRVRDCDSLLLGPDESLLYVGARDAVLALNVSDPNEPRLVATVPWGPTEEKKRECSLKRKSPETECFNFIRVLVALNRSHLYACGTNAFSPACTHILLENFTLPRAAVGQRDGKGQSPFDPRHSHTALLDGGELYAATANNFHGTEPVISRSLGARTALKTDAFLRWLAGGEPPHRDKWGALPHRDGWGSLPHRDGWGALPHRDKWGALPHRDEWGALPHRDGWGALPHRDKWGHPKETSTPWCSAGSSSDQLLSFMKDHFLMESRVVPTHGRPLLLSAASYTHIAVHQTRGAAGTEHRVLLMATDTGFLHKAVEVGEGRAHIVESVQMFEEPQRVSSVLLSASKDVLYVGHAGGVLVLPLSNCSQHRSCTECVLARDPHCDRTPLTDPINIPPLPDPINSPWLQDGYGAIWAQGCLVSWLWGRVLTVSPRFPPCPPVCVPVPVALTPPVHSLLRLPCPPRSAWASYSWEQPVGARGVTEQLPDLTLLVAAQPRTAGTYTCWATENGARWAVVRYRLQEPHEAPERGGCGMLDGAATSGSYRARFVAVTALLALTLVAAAGLGLVAYRARSKVRGCPGGGGEKKPLNGGGERGCCLQMDGNGRERGDGGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TWE0</accession>
    <name>A0A8C2TWE0_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RAB20, member RAS onco family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">RAB20</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TWE0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005027222.1">
        <property type="protein sequence ID" value="ENSCJPP00005019688.1"/>
        <property type="gene ID" value="ENSCJPG00005015930.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161024"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045335">
        <property type="term" value="C:phagocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071346">
        <property type="term" value="P:cellular response to type II interferon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090383">
        <property type="term" value="P:phagosome acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090385">
        <property type="term" value="P:phagosome-lysosome fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981">
        <property type="entry name" value="RAB FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981:SF20">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB-7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005019688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="217" mass="23313" checksum="0FB9BD8B14EC6F7B" modified="2022-01-19" version="1">MVGAARGGAAFVPPLPEPGGAMKKPDGKVVLLGDMNVGKTSLLHRYMERRFQDTVSTLVGNAASSTLTYVAFKPLPGREQFHGLGSMYCRGAAAVILTYDVNSLQSLVELEDRFLALTDSASADCIFAIVGNKVDLSDDCASPPDENRPEKAIAGCSSKKMCFETSAKTGYKVDYLFETVFDMVVPIIVRQKAEGPPQTVDITDYKPAKRTKSSCCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TWZ6</accession>
    <name>A0A8C2TWZ6_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Family with sequence similarity 76 member A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FAM76A</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM76 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TWZ6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005027520.1">
        <property type="protein sequence ID" value="ENSCJPP00005019915.1"/>
        <property type="gene ID" value="ENSCJPG00005016099.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160073"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032017">
        <property type="entry name" value="FAM76"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46176">
        <property type="entry name" value="LD21662P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46176:SF2">
        <property type="entry name" value="PROTEIN FAM76A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16046">
        <property type="entry name" value="FAM76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="179"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="354"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005019915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="376" mass="42300" checksum="F3F7816A84A733E9" modified="2022-01-19" version="1">MRRCVGGLSGGRPRRFGCACQPRRRMAALYACTKCHQRLPFEALSQGQQLCKECRIAHPIVKCTYCRTEFQQESKTNTICKKCAQNVKLYGTPKPCQYCNIIAAFIGNKCQRCTNSEKKYGPPHSCEQCKQQCAFDRKDDRKKVDGKLLCWLCTLSYKRVLQKTKEQCKHLSSSSRTSLQEKEQYSRLSSSSHYNSQKTLSTSSIQNEIPKKKAKFDAISANGDSVPSSPEMLCPPIQSAPSTLAQWAASQQSLGAHHCPVSQGTDILNFSPDLALDSPGTDHFVIIAQLKEEVATLKKMLHQKDQMILEKEKKITELKADLQYQESQMRAKMNQMEKTHKEVMEQLQAKNRELLKQAAALSKGKKPEKSGAITSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TX14</accession>
    <name>A0A8C2TX14_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TX14"/>
    <dbReference type="Ensembl" id="ENSCJPT00005024892.1">
        <property type="protein sequence ID" value="ENSCJPP00005017904.1"/>
        <property type="gene ID" value="ENSCJPG00005014547.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286941"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001968">
        <property type="entry name" value="chorion transcription factor Cf2 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000506">
        <property type="entry name" value="Zinc finger protein 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226:SF416">
        <property type="entry name" value="FI01424P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226">
        <property type="entry name" value="ZINC FINGER AND SCAN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="107"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="135"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="56"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005017904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="202" mass="23041" checksum="F9C1232F3B6417C2" modified="2022-01-19" version="1">VDQNPLQGCEGLLWGQGVSPLLQTAPLKKPACLASAYLYNQKQRNPPGEIVRISLDSRTGQKQTEDAGSKEMCQEKRQNPSAENEKILERNSSLVSHHCVYSVKRLYKCSDCTKSFKWKSHLTCHQRIHSEERPFKSPDCPKSFKTNSHLMGHQRIHKGERPINKVWWEGFCDMCAVCTGWLSRTDRQGKRDSMVLLLVMVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TY27</accession>
    <name>A0A8C2TY27_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TY27"/>
    <dbReference type="Ensembl" id="ENSCJPT00005027028.1">
        <property type="protein sequence ID" value="ENSCJPP00005019524.1"/>
        <property type="gene ID" value="ENSCJPG00005015814.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005019524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="65" mass="7239" checksum="99A11701C1E3D2AE" modified="2022-01-19" version="1">MSTAPLSLVNIPLVSKSIELTTEIILNQMGCSEYHPQLINYCSNTEIQISMLQLCYCHHNTGDSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TY62</accession>
    <name>A0A8C2TY62_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transcriptional adaptor 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">TADA3</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NGG1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TY62"/>
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        <property type="protein sequence ID" value="ENSCJPP00005020619.1"/>
        <property type="gene ID" value="ENSCJPG00005016577.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000008947"/>
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        <property type="component" value="Chromosome 12"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="C:transcription factor TFTC complex"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:nuclear receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="F:protein domain specific binding"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:transcription coactivator activity"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:chromatin organization"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:regulation of cell cycle"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:regulation of cell division"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:regulation of protein stability"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="Histone_AcTrfase_su3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13556:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13556">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10198">
        <property type="entry name" value="Ada3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="73"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
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            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="464"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="558"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="160"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="500"/>
            <end position="510"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005330"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005020619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="620" mass="68415" checksum="A8A3707B0AF55E6F" modified="2022-01-19" version="1">MVSAPVRSVEAEPEVAGCLFLDAREGPTRSCVGALCSLSVPVPFPVPSRPPTPCICIYVYICVSVCISGRSRGAAAAPGGGGETPRDSTPPAIPPLLVRSVRRFHIRKGRRRDERTNRLRAPGGAEPMGREGRGEAAGAGSSRAAQCKPGPPRPCPLPAPRRDPPSSGRHRETGQQASIAARFRPGAAMSELKDCPLQFHDFKSVDHVKVCPRYTAVLARSEDDGIGIEELDTLQLELETLLSSASRRLRVLEAETQILTDWQDKKGDRRFLKLSKEHDVGTSVKHGKPKKQKLEGKGGHGTGPGPGRPKSKNLQPKIQEYEFQDDPIDVPRIPKNDAPNRFWASVEPYCADLTNEEVRVLEELLKPPEDEAEHYKIPPLGKHYSQRWAQEDLLEEQKDGARAAAAADKKKGVLGPLTELDTKDVDALLKKSEAQHEQPEDGCPFGPLTQRLLQALVEENIISPVEDSPIPDIAGKDSGADGAGTSPRSQNKPFSVPHTKSLEGRIKEELVAQGLLESEDRPAEDSEDEVLAELRKRQAELKALSAHNRAKKHELLRLAKEELHRQELRQRVRMADNEVMDAFRKIMAARQKKRTPTKKEKDQAWKTLKERESILKLLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TYH0</accession>
    <name>A0A8C2TYH0_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Shugoshin-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC107316590</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the shugoshin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015723773.1">
        <property type="nucleotide sequence ID" value="XM_015868287.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TYH0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005027859.1">
        <property type="protein sequence ID" value="ENSCJPP00005020190.1"/>
        <property type="gene ID" value="ENSCJPG00005016282.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107316590"/>
    <dbReference type="GeneTree" id="ENSGT00960000187202"/>
    <dbReference type="OrthoDB" id="5990092at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051177">
        <property type="term" value="P:meiotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038889">
        <property type="entry name" value="Shugoshin1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21577">
        <property type="entry name" value="SHUGOSHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21577:SF3">
        <property type="entry name" value="SHUGOSHIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="8" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="167"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="551"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="727"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="829"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="13"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="551"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="566"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="592"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="727"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="763"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005020190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="848" mass="93135" checksum="088C6C48172B18D0" modified="2022-01-19" version="1">MPLRVPISKPRNLRQQSGSSTAMQKSSLGLQTCAPDKPLETLSVSEDALPPQFAGKTQSHQEENGKNQREGMGAQEAFLDSCPSRESLCATQQNNNLSAPAWESCPLLYEDEMVKRFCDRLSQGHVTQRRKHSAWFAASTQSSNVDIIPHVASTRATWCGITEDSSNFSEDNVQPQLKSPSSLASPTEATVSPNRRLPVKEAFCDQLQAEETGCSVEVDSTSNDVMESIPVKIRSKVKRKTDEIKTVKKTSAGRKKTNVIKTSAKNGPDIPQSKEKNQNAEKPILSEVALWSNRSEASDMEQKACVGALDLKNRGSGVVQCSCSPNKVSIRRTYIVNQPQLSDLGSGGLVQVKKDGIVELQSMESSLLEIPGHAVSSHEDPSVDCSLQNLLLLRDGTSSVRALQEDSSNVTTKSSRRKTNRKTRVICQINDFVGNLPSSMENIPEAKAEEQCKNNQTKRRKTVTKSSCSGQKHEGDFGSFAGVQGIAEDGTRNSLDKHRKRTYVVCPLDLTENLDCVQTDFEKDKVVPSTQCAPGSKASKIPRVKRMVAAQNNKKQTGHPQENEQTKVVNAGSLQKESSCKSRPRRKRKTSASPDTNSVAKQSDDGASVLRESSMELVSKQTVLIKKYFSPTNLLSELGASLEEQIADISLSKKLMDLSQSFESSSVICSADLPVSCGLTDLPVSKSSEAEDKGTTEKSPLCPERSLLFKERTAQKASEEINQVASSFKHCSQSSPSKEPEIKPLQDLTNARTPSLVPSLEEIPERTSRRRPDPACYREPSLKCKLRQGDPFTNTEFLHCSVNKTKKKKRPKPKELTKNIKEELLPVELPTANASKLTAMGDEKQEVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U138</accession>
    <name>A0A8C2U138_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U138"/>
    <dbReference type="Ensembl" id="ENSCJPT00005029919.1">
        <property type="protein sequence ID" value="ENSCJPP00005021825.1"/>
        <property type="gene ID" value="ENSCJPG00005017424.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000235231"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034297746" description="Secreted protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005021825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="184" mass="17704" checksum="C7620E27F5B66898" modified="2022-01-19" version="1">VFSSVWLLSTVSIWGCAVALAVASSAAGVVVAVVSAAGTSACLGSSLSWASSAFKDGELSVEALVALSVSAAAAGFSSEEAAGVAACGAGCSEPVSAAPSPFFSSAGALLSLLPSSTWALSAALASVAAEASLSLFSAAPPAGPSSFLSAASDSDAGASAFFSPLSFFLVMCPRKLAWILVAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U1G6</accession>
    <name>A0A8C2U1G6_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-like-conjugating enzyme ATG3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Autophagy-related protein 3</fullName>
        </alternativeName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATG3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2U1G6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005029973.1">
        <property type="protein sequence ID" value="ENSCJPP00005021874.1"/>
        <property type="gene ID" value="ENSCJPG00005017469.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000010308"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019776">
        <property type="term" value="F:Atg8-family ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044804">
        <property type="term" value="P:nucleophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007135">
        <property type="entry name" value="Atg3/Atg10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12866">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12866:SF2">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03987">
        <property type="entry name" value="Autophagy_act_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005021874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="83" mass="9268" checksum="2C1F5F58EB27EF76" modified="2022-01-19" version="1">MQNVINTVKGKALEVAEYLTPVLKESKFKETGVITPEEFVAAGDHLVHHCPTWQWASGEELKVKAYLPTDKQFLVTKNGKAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U2A3</accession>
    <name>A0A8C2U2A3_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Extracellular calcium-sensing receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">CASR</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="18">Homodimer; disulfide-linked. Interacts with VCP. Interacts with ARRB1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015728959.1">
        <property type="nucleotide sequence ID" value="XM_015873473.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U2A3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005028671.1">
        <property type="protein sequence ID" value="ENSCJPP00005020815.1"/>
        <property type="gene ID" value="ENSCJPG00005016705.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107318997"/>
    <dbReference type="KEGG" id="cjo:107318997"/>
    <dbReference type="CTD" id="846"/>
    <dbReference type="GeneTree" id="ENSGT00940000157596"/>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007193">
        <property type="term" value="P:adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005513">
        <property type="term" value="P:detection of calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007200">
        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900227">
        <property type="term" value="P:positive regulation of NLRP3 inflammasome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051924">
        <property type="term" value="P:regulation of calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099505">
        <property type="term" value="P:regulation of presynaptic membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd15282">
        <property type="entry name" value="7tmC_CaSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06364">
        <property type="entry name" value="PBP1_CaSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000016">
        <property type="entry name" value="Taste 1 receptor member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.30:FF:000002">
        <property type="entry name" value="Vomeronasal 2 receptor, h1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000388">
        <property type="entry name" value="Vomeronasal 2, receptor 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.30">
        <property type="entry name" value="GPCR, family 3, nine cysteines domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011500">
        <property type="entry name" value="GPCR_3_9-Cys_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038550">
        <property type="entry name" value="GPCR_3_9-Cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000068">
        <property type="entry name" value="GPCR_3_Ca_sens_rcpt-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017979">
        <property type="entry name" value="GPCR_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24061">
        <property type="entry name" value="CALCIUM-SENSING RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24061:SF358">
        <property type="entry name" value="EXTRACELLULAR CALCIUM-SENSING RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07562">
        <property type="entry name" value="NCD3G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00592">
        <property type="entry name" value="CASENSINGR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00979">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00980">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00981">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-0675">Receptor</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 21" id="KW-0732">Signal</keyword>
    <keyword evidence="16" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034891576" description="Extracellular calcium-sensing receptor" evidence="21">
        <location>
            <begin position="25"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="616"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="654"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="686"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="729"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="774"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="808"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="836"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="22">
        <location>
            <begin position="616"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="896"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="959"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1002"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="904"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1011"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1042"/>
            <end position="1064"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00039746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00093527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005020815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1064" mass="118544" checksum="2B2393A58504179E" modified="2022-01-19" version="1">MKGGTMTLYSCCLILLLFTWNTAAYGPNQRAQKKGDIILGGLFPIHFGVAAKDQDLKSRPESVECIRYNFRGFRWLQAMIFAIEEINNSPNLLPNMTLGYRIFDTCNTVSKALEATLSFVAQNKIDSLNLDEFCNCSEHIPSTIAVVGATGSGVSTAVANLLGLFYIPQVSYASSSRLLSNKNQFKSFLRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGIEKFREEAEERDICIDFSELISQYSDEEEIQQVVEVIQNSTARVIVVFSSGPDLEPLIKEIVRRNITGKIWLASEAWASSSLIAMPEFFRVIGSTIGFALKAGQIPGFREFLQKVHPKKSANNGFAKEFWEETFNCYLPSESKNSPASASFHKAHEEGLGAGNGTAAFRPPCTGDENITSVETPYMDFTHLRISYNVYLAVYSIAHALQDIYTCTPGKGLFTNGSCADIKKVEAWQVLKHLRHLNFTSNMGEQVDFDEFGDLVGNYSIINWHLSPEDGSVVFEEVGHYNVYAKKGERLFINENKILWSGFSKEVPFSNCSRDCLPGTRKGIIEGEPTCCFECVDCPDGEYSDETDASACDKCPEDYWSNENHTSCIPKQIEFLSWTEPFGIALTLFAVLGIFLTSFVLGVFTKFRNTPIVKATNRELSYLLLFSLLCCFSSSLFFIGEPQNWTCRLRQPAFGISFVLCISCILVKTNRVLLVFEAKIPTSLHRKWWGLNLQFLLVFLCTFVQIVICVIWLYTAPPSSYRNHELEDEIIFITCHEGSLMALGFLIGYTCLLAAICFFFAFKSRKLPENFNEAKFITFSMLIFFIVWISFIPAYASTYGKFVSAVEVIAILAASFGLLACIFFNKVYIILFKPSRNTIEEVRCSTAAHAFKVAARATLRRSNVSRKRSNSLGGSTGSTPSSSISSKSNHEDPFPLPASAERQRQQQRGCKQKVSFGSGTVTLSLSFEEPQKNAMANRNAKRRNSLEAQNSDDSLMRHRALLALQNSESLSAEPGFQTASSPETSSQESVVGDNKEEVPNPEAEPSLPSANSRNFIGTGGSSVTENTVHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U2V2</accession>
    <name>A0A8C2U2V2_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SLAIN motif-containing protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC107312829</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SLAIN motif-containing family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2U2V2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005029040.1">
        <property type="protein sequence ID" value="ENSCJPP00005021113.1"/>
        <property type="gene ID" value="ENSCJPG00005016912.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000017860"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035371">
        <property type="term" value="C:microtubule plus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031116">
        <property type="term" value="P:positive regulation of microtubule polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026179">
        <property type="entry name" value="Slain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22406">
        <property type="entry name" value="NASCENT POLYPEPTIDE-ASSOCIATED COMPLEX SUBUNIT ALPHA, MUSCLE-SPECIFIC FORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22406:SF5">
        <property type="entry name" value="SLAIN MOTIF-CONTAINING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15301">
        <property type="entry name" value="SLAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="492"/>
            <end position="552"/>
        </location>
    </feature>
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            <begin position="564"/>
            <end position="611"/>
        </location>
    </feature>
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        <location>
            <begin position="635"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="494"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="573"/>
            <end position="589"/>
        </location>
    </feature>
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        <location>
            <begin position="645"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="696"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005021113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="713" mass="77010" checksum="A7FBAB8B75799166" modified="2022-01-19" version="1">MPAGMEHPQPPCAACSSASPPMLAYSSARLSFSAIQCTLLKALCVFPVSQQSGVSQMMVVPGSAPLIQQDRALEPDVGRGPTQSSAMGPGTEPAPGEVGPELEEVRKLQELVRRLEIQNQHLRTRSRRSVLGTALQGEMRSGVDNHDSGLNGMEINNSINAMAEKQELQIMADLHSKLSKIRREEGENNCFKRDMGAQTQYGCLSAPEELPSDMCKVEVKTDDNVRCLSRVDSGGSTELMGNLLIAGNESTVTINQPNPSEKGGDLAGILNNSALDEVKVLELENCNEEEDSWLYVSPRKSAVSHKTGSPLQWCRQVLDNPSPETEAACRTLISRLDQASRWKNLYCSPLASPSAHNLNTETGSCSNALNSPGHLKSTNKALLTCGSSGYLSMHSALSSQSSVDSELSTSDDSISMGYKLQDLTDVQVMARLQEESLRQDCASSSASVSRRSSSASLHSLRRGTYSDQEFDTYSLEDEDDYDCSLSYRSAHRYSPSPLSSPRCQSPSSSADYSRASASRIRPPRRSVQSPMQDRLKYASSEEEMRHSMPNLARTSLRALESVRSSRSLESDLQVPSTRLSRIQQPSASLAPSKLRYSSGAGQSPLTVRQPMKAGSCTNSLLTARQPVKACSYTAPVSGVRKPQASSLSTGPSGGSSNTRSMVTMAKSSPIKPRTSVGGTSVPRSKLTPPSKRFLQSAKTTPNTVDDSWKDGCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U4D9</accession>
    <name>A0A8C2U4D9_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Actin-associated protein FAM107A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">FAM107A</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="21">Stress-inducible actin-binding protein that plays a role in synaptic and cognitive functions by modulating actin filamentous (F-actin) dynamics. Mediates polymerization of globular actin to F-actin. Also binds to, stabilizes and bundles F-actin. Involved in synaptic function by regulating neurite outgrowth in an actin-dependent manner and for the acquisition of hippocampus-dependent cognitive function, such as learning and long-term memory. Plays a role in the actin and microtubule cytoskeleton organization; negatively regulates focal adhesion (FA) assembly promoting malignant glial cell migration in an actin-, microtubule- and MAP1A-dependent manner. Also involved in neuroblastoma G1/S phase cell cycle progression and cell proliferation inhibition by stimulating ubiquitination of NF-kappa-B subunit RELA and NF-kappa-B degradation in a COMMD1- and actin-dependent manner. May play a role in tumor development.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell junction</location>
            <location evidence="3">Focal adhesion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cell projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Stress fiber</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="19">Synapse</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2U4D9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005028853.1">
        <property type="protein sequence ID" value="ENSCJPP00005020979.1"/>
        <property type="gene ID" value="ENSCJPG00005016807.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000011228"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="C:focal adhesion"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032587">
        <property type="term" value="C:ruffle membrane"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051895">
        <property type="term" value="P:negative regulation of focal adhesion assembly"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:negative regulation of G1/S transition of mitotic cell cycle"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of cell migration"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:regulation of actin cytoskeleton organization"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:regulation of cell growth"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070507">
        <property type="term" value="P:regulation of microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031647">
        <property type="term" value="P:regulation of protein stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009533">
        <property type="entry name" value="FAM107"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16768:SF3">
        <property type="entry name" value="ACTIN-ASSOCIATED PROTEIN FAM107A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16768">
        <property type="entry name" value="DOWN REGULATED IN RENAL CARCINOMA 1/TU3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06625">
        <property type="entry name" value="DUF1151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="14" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="18" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9" id="KW-0965">Cell junction</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="17" id="KW-0966">Cell projection</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0341">Growth regulation</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0346">Stress response</keyword>
    <keyword evidence="11" id="KW-0770">Synapse</keyword>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="105"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="105"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00040095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00045129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005020979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="144" mass="17148" checksum="2A57EA7D3E62AFE7" modified="2022-01-19" version="1">MYTEIQQEHCDSRSILSQPDYIDGNPDLIKPKKLLNPVKASKSHQELHRELLMNHKRGLSVDSKPELQRVLEHRRRNQVLRQKKEEEEAKKLQSPFEKELLKRHQRLDQLEKEQEKQEDHAPEFIKVKENLRRTSTVTGEEKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U562</accession>
    <name>A0A8C2U562_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">E3 ubiquitin-protein ligase CBL</fullName>
            <ecNumber evidence="13">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">CBLB</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="13"/>
    <dbReference type="RefSeq" id="XP_015733118.1">
        <property type="nucleotide sequence ID" value="XM_015877632.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U562"/>
    <dbReference type="Ensembl" id="ENSCJPT00005030262.1">
        <property type="protein sequence ID" value="ENSCJPP00005022061.1"/>
        <property type="gene ID" value="ENSCJPG00005017633.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107321076"/>
    <dbReference type="CTD" id="868"/>
    <dbReference type="GeneTree" id="ENSGT00940000156631"/>
    <dbReference type="OrthoDB" id="7237699at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098794">
        <property type="term" value="C:postsynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001784">
        <property type="term" value="F:phosphotyrosine residue binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030971">
        <property type="term" value="F:receptor tyrosine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035739">
        <property type="term" value="P:CD4-positive, alpha-beta T cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000562">
        <property type="term" value="P:negative regulation of CD4-positive, alpha-beta T cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050860">
        <property type="term" value="P:negative regulation of T cell receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045732">
        <property type="term" value="P:positive regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031398">
        <property type="term" value="P:positive regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002669">
        <property type="term" value="P:positive regulation of T cell anergy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000583">
        <property type="term" value="P:regulation of platelet-derived growth factor receptor-alpha signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099149">
        <property type="term" value="P:regulation of postsynaptic neurotransmitter receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140252">
        <property type="term" value="P:regulation protein catabolic process at postsynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002870">
        <property type="term" value="P:T cell anergy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050852">
        <property type="term" value="P:T cell receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd16709">
        <property type="entry name" value="RING-HC_Cbl-b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09920">
        <property type="entry name" value="SH2_Cbl-b_TKB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14392">
        <property type="entry name" value="UBA_Cbl-b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000022">
        <property type="entry name" value="E3 ubiquitin-protein ligase CBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.20:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase CBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000015">
        <property type="entry name" value="E3 ubiquitin-protein ligase CBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000154">
        <property type="entry name" value="E3 ubiquitin-protein ligase CBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000037">
        <property type="entry name" value="E3 ubiquitin-protein ligase CBL-B isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.20">
        <property type="entry name" value="Adaptor protein Cbl, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024162">
        <property type="entry name" value="Adaptor_Cbl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014741">
        <property type="entry name" value="Adaptor_Cbl_EF_hand-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036537">
        <property type="entry name" value="Adaptor_Cbl_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003153">
        <property type="entry name" value="Adaptor_Cbl_N_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014742">
        <property type="entry name" value="Adaptor_Cbl_SH2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039520">
        <property type="entry name" value="CBL-B_RING-HC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024159">
        <property type="entry name" value="Cbl_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23007">
        <property type="entry name" value="CBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23007:SF3">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CBL-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02262">
        <property type="entry name" value="Cbl_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02761">
        <property type="entry name" value="Cbl_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02762">
        <property type="entry name" value="Cbl_N3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47668">
        <property type="entry name" value="N-terminal domain of cbl (N-cbl)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51506">
        <property type="entry name" value="CBL_PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 13" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 13" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 12 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Cbl-PTB" evidence="17">
        <location>
            <begin position="80"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="16">
        <location>
            <begin position="418"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="15">
        <location>
            <begin position="968"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="513"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="721"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="789"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
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        <location>
            <begin position="518"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="589"/>
            <end position="612"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="645"/>
            <end position="659"/>
        </location>
    </feature>
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        <location>
            <begin position="798"/>
            <end position="807"/>
        </location>
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    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="816"/>
            <end position="825"/>
        </location>
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    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="861"/>
            <end position="870"/>
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        <location>
            <begin position="880"/>
            <end position="890"/>
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        <location>
            <begin position="920"/>
            <end position="940"/>
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            <dbReference type="ARBA" id="ARBA00004496"/>
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            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
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        <source>
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        <source>
            <dbReference type="RuleBase" id="RU367001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
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            <dbReference type="PROSITE" id="PS50089"/>
        </source>
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        <source>
            <dbReference type="PROSITE" id="PS51506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005022061.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
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    </evidence>
    <sequence length="1024" mass="114182" checksum="CA6560B5C433D773" modified="2022-01-19" version="1">MLRGEERPPERRGAGEGAGRPELRQPHFPGARGDHSPPAAVSCAAYRPPSSQMANSQNGRNPRKGRILGFIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAADFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLFPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDENSRCCSIIDSFSMPMLDLDDDDDREESLMMNRLASVRKCNERQNSPVTSPGSSPLAQRRKPLPDPLQIPHLSLPPVPPRLDLIQKGVARSPCASPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRISRHLHHPESVPSRDQPMPLEGWCPRDVFGTSQLVGSRTGSDTSPKPGLTAGSNINGRHNRISSEQGFMRKHRRHELPVEGAKVFSNGHLINEEYDVPPRLSPPLPAASTIPNIKCPVSSANSLSDKSRDHTDDDDEYKVPSSHSIILGSQPPHCHNIKPVARVCENGQCAGVTNGTHSATSDVKKSKHPELGDVYDAPTVPVPLPPARPPTRDNPKHSSLLNRTPSDYDLLVPPLGDDAFDSSPPSLPPPPPPARHSITEHTKPSGSGSRPPSGHELFLHPDPHFDPIAGHVPLPPVRRVTGENVKTNRTSQDYDQLPPSSDGSQAPARPPKPLPRRTAPEIHHRKAFNSDSSTENVDAKIAKLMGEGYSFEEVKRALEIAQNNIDVARSILREFVCFPPPVSPRLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U5E1</accession>
    <name>A0A8C2U5E1_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the SOWAH family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2U5E1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005032501.1">
        <property type="protein sequence ID" value="ENSCJPP00005023771.1"/>
        <property type="gene ID" value="ENSCJPG00005018786.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183003"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
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    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14491:SF8">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN SOWAHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14491">
        <property type="entry name" value="SOSONDOWAH, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005023771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="299" mass="33207" checksum="976EC3F272C9150F" modified="2022-01-19" version="1">MYILTGLSSVGYVLQVFPLDLNWKTFPSTATDVSFSKADGKLRKTVTQARRAVSRLCSGPSSTQRKELREILLQSSSLSQTMCFAAMQMASSGPGLFTGPQEQEVLEQRPRVLSLTLHREWLLAMARGDTVNILRLLDQDPSLLSAADPVTGFSVLHWLAKHGHQKSFAEVISHAQKKGCPINMNIRTTMGGFTPLCLAAQQGHASLIEVLVKEYKADTSLRDHSGRKAWQYLREDTSRELMELAGALEENSAQPGTHSSNCGKDHKDVAAKRRALCHWRQLSVPKFIKKASACWFIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U6E2</accession>
    <name>A0A8C2U6E2_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytoskeleton associated protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">CKAP4</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015719557.1">
        <property type="nucleotide sequence ID" value="XM_015864071.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U6E2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005031542.1">
        <property type="protein sequence ID" value="ENSCJPP00005023015.1"/>
        <property type="gene ID" value="ENSCJPG00005018288.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107314620"/>
    <dbReference type="KEGG" id="cjo:107314620"/>
    <dbReference type="CTD" id="10970"/>
    <dbReference type="GeneTree" id="ENSGT00390000015968"/>
    <dbReference type="OrthoDB" id="9944809at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="C:mitochondrion"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005791">
        <property type="term" value="C:rough endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45161">
        <property type="entry name" value="CYTOSKELETON-ASSOCIATED PROTEIN 4"/>
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    </dbReference>
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        <property type="entry name" value="CYTOSKELETON-ASSOCIATED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
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        <location>
            <begin position="106"/>
            <end position="168"/>
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        <location>
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            <end position="278"/>
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    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="328"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="527"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="46"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005023015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="562" mass="62164" checksum="86B5F8DD12947206" modified="2022-01-19" version="1">MSAAKHRGPKGGSPPAAANERGAQPGGSEEAAAKKPAAASSHGRGGRSGAGGGGGRSGAGQQRGWALLLGAVVVLGAALPAGWYVRQLREEVGRSAREREASGRQRQELAATLDAVAQKVRSLQATFGDFESMMKIAQQKQEVTEKAVKQGENEINRISDVLQKLQNEILKDLSDGIHMVKDARERDFTSLENTVEERLTELTKSINDNIAVFTEVQQRSQDEIKNMKAKVDSLEKADAYKHEIKVLKDAFGEMQASLKTKAKDIETLKNTINSMESDVYTEVKELVNLKQEHEKFKEAADTEHLSLKALQEKVLRAEESIMQLPGDIKRLDEDLLHIKAELSKWEENELFRKALETFENNSEGLESRLRHIEESLKSVSSIASQHGEKLQSFLSKEAEYDNKLSTLEQSMSGLQGISDMDITSVSDVLKNLGESQTSLYNDVEDLRRSISDLPSSGALEDVQKQISILLDQGSLQMDQAHSQGYLEKFNSVEGSVDELRSSVSQVDSDLKMIRTAVDSLVSYSVKIENNENNLESVKSSIDDLRNDLERLFVKVEKIHEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U8X4</accession>
    <name>A0A8C2U8X4_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">G-protein coupled receptor 171</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">GPR171</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015727646.1">
        <property type="nucleotide sequence ID" value="XM_015872160.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U8X4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005032398.1">
        <property type="protein sequence ID" value="ENSCJPP00005023671.1"/>
        <property type="gene ID" value="ENSCJPG00005018736.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107318397"/>
    <dbReference type="KEGG" id="cjo:107318397"/>
    <dbReference type="CTD" id="29909"/>
    <dbReference type="GeneTree" id="ENSGT01110000267167"/>
    <dbReference type="OrthoDB" id="9935079at2759"/>
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        <property type="component" value="Chromosome 9"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:G protein-coupled purinergic nucleotide receptor activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042923">
        <property type="term" value="F:neuropeptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008188">
        <property type="term" value="F:neuropeptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045638">
        <property type="term" value="P:negative regulation of myeloid cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060259">
        <property type="term" value="P:regulation of feeding behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051930">
        <property type="term" value="P:regulation of sensory perception of pain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd15167">
        <property type="entry name" value="7tmA_GPR171"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000206">
        <property type="entry name" value="Probable G-protein coupled receptor 171"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048077">
        <property type="entry name" value="GPR171"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24233:SF4">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 171"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24233">
        <property type="entry name" value="P2Y PURINOCEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01157">
        <property type="entry name" value="P2YPURNOCPTR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="31"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00070742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005023671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="325" mass="37764" checksum="B77DE3F76D03068A" modified="2022-01-19" version="1">MPNNASQCYIKTELEPFTYFYYLIFLMGFLGSCFALWAFMQKDEQQKCMSIYLINLLTADFLLTLALPVKIIVDLGVAPWKLQIFHCQVTACLIYLNMYLSIIFLGFVSMDRYLQLMHSSKIYRIQEPGFAKILSAVVWTMLLLITVPNMAIPIKTIEERPNARCIDFKTKFGRDWHVFTNFVCTAIFLNFSAMILISNFLVVRQLYINKYSESYRNVKKALVSILLLTAAYLLCFLPYHVVRIPYTLSQSDAITSCSVKQTLFHAKESTLLFAISNLCFDPILYYRLSKVFRLKVTEAFIASKQAKVSIEEEAQHRSEHWVQRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U9K7</accession>
    <name>A0A8C2U9K7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Actin filament-associated protein 1-like 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">AFAP1L2</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">May play a role in a signaling cascade by enhancing the kinase activity of SRC. Contributes to SRC-regulated transcription activation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015722842.1">
        <property type="nucleotide sequence ID" value="XM_015867356.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U9K7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005034784.1">
        <property type="protein sequence ID" value="ENSCJPP00005025583.1"/>
        <property type="gene ID" value="ENSCJPG00005020073.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107316137"/>
    <dbReference type="CTD" id="84632"/>
    <dbReference type="GeneTree" id="ENSGT00950000183067"/>
    <dbReference type="OrthoDB" id="8443615at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030296">
        <property type="term" value="F:protein tyrosine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042169">
        <property type="term" value="F:SH2 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
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        <property type="term" value="P:regulation of mitotic cell cycle"/>
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        <property type="entry name" value="Actin filament-associated protein 1-like 2 isoform 1"/>
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        <property type="entry name" value="ACTIN FILAMENT-ASSOCIATED PROTEIN 1 FAMILY MEMBER"/>
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        <property type="entry name" value="ACTIN FILAMENT-ASSOCIATED PROTEIN 1-LIKE 2"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
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        <location>
            <begin position="175"/>
            <end position="271"/>
        </location>
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    <feature type="domain" description="PH" evidence="9">
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            <begin position="353"/>
            <end position="447"/>
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            <begin position="301"/>
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            <begin position="751"/>
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            <begin position="662"/>
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            <begin position="123"/>
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            <begin position="313"/>
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        <source>
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    <sequence length="820" mass="91989" checksum="944B0CEB6F511F21" modified="2022-01-19" version="1">MEKYKALEQLLTELEDFLRILDKENLSSTALVKKSFLSDLLRVYTKSSGGDEEYIYMNKVTVNRQQGDQEKQDKALDGKNSLTNGDLGPHSSPPQKSLPELPPPKIPETKQPSVPKIESPEGYYEEAEPYDVSMNEDGEAVSSSYESYDEEESSKGKSATHQWPSTEATIELMKDARICAFLWRKKWLGQWAKQLCVIKDTRLLCYKSSKDHSPQLDVNLLGCTVIHKEKQVRKKEHKLKIIPMNADVIVLGLQSKDQAEQWLRVIQETSGLQCEGGSEGNQYIPDSQRLNYPKVDLSERYSAASESGSSTDGHPEAVETKDVKKKGTTGLKLSNLMNLGRKKSSSLDSPERSLETSSYLNVLVNSQWKSRWCQIKDGHLHFYQDKNRSKLAQQPLSLAGCEVIPEPSPDHLYSFRILHNGEERVVLEAKSSEEMGHWLGLLLSESGSKTDPEEFTYDYVDADRVSCIVSAAKNSFFLMQRKYSEPNAYIDNLPKGKVEQEELYDDVDLPDVPVEEVPKSESKLEGDQDRVYLDLTPVKSFLHCAGKKPSQPSSLSSPALERAGNKAAADSTAETAPVNKDAEPCEKEETSEQKHPEKPEPEEPPPQMPTVKIQTQQQNITFPQTNPEPPAGFVPVGSPQLMPAHRPKMPLPVAAVETKLGKNRTEAEVKRFTEEKERLEKEKDEIRAQLTQLRKERRELKEMLASCTDKNLEQRLKEIDEECKRKESRRVDLELSLVEVKENLKKAESGPVTLGTTVDTTHLENTAPRTQTKPATPATSTESSPVNSATALKNRPLSVMVTGKGTVLQKAKEWEKKGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U9V4</accession>
    <name>A0A8C2U9V4_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Dedicator of cytokinesis 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">DOCK9</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DOCK family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSCJPT00005032651.1">
        <property type="protein sequence ID" value="ENSCJPP00005023902.1"/>
        <property type="gene ID" value="ENSCJPG00005016181.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155972"/>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08697">
        <property type="entry name" value="C2_Dock-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11698">
        <property type="entry name" value="DHR2_DOCK9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13267">
        <property type="entry name" value="PH_DOCK-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.740:FF:000001">
        <property type="entry name" value="dedicator of cytokinesis protein 9 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="dedicator of cytokinesis protein 9 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="dedicator of cytokinesis protein 9 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="dedicator of cytokinesis protein 9 isoform X2"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
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        <property type="entry name" value="ARM-type_fold"/>
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        <property type="entry name" value="C2_Dock-D"/>
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        <property type="entry name" value="DOCK"/>
    </dbReference>
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        <property type="entry name" value="DOCK_C/D_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043161">
        <property type="entry name" value="DOCK_C_lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043162">
        <property type="entry name" value="DOCK_C_lobe_C"/>
    </dbReference>
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        <property type="entry name" value="DOCKER_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046769">
        <property type="entry name" value="DOCKER_Lobe_A"/>
    </dbReference>
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        <property type="entry name" value="DOCKER_Lobe_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046773">
        <property type="entry name" value="DOCKER_Lobe_C"/>
    </dbReference>
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        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23317">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23317:SF77">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06920">
        <property type="entry name" value="DHR-2_Lobe_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20422">
        <property type="entry name" value="DHR-2_Lobe_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20421">
        <property type="entry name" value="DHR-2_Lobe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14429">
        <property type="entry name" value="DOCK-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11878">
        <property type="entry name" value="DOCK_C-D_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51650">
        <property type="entry name" value="C2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51651">
        <property type="entry name" value="DOCKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="6">
        <location>
            <begin position="175"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="C2 DOCK-type" evidence="7">
        <location>
            <begin position="640"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="domain" description="DOCKER" evidence="8">
        <location>
            <begin position="1630"/>
            <end position="2057"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="291"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1259"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1940"/>
            <end position="1967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="306"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1268"/>
            <end position="1277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005023902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="2095" mass="239690" checksum="5B6F95A02D7B48FC" modified="2022-01-19" version="1">MSHQAAMALAAPETRKFTRALSKPGTAAELRQSVSEVVRGSVLVAKPKLIEPIDYENVIVQRKTQILNDALREMLLFPYDDFQTALLKRQSRYIHSTVPENAEKEAQSLFVTECIKTYNSDWHVVNYKYEDYSAEFRQLPNKVTKPEKLPVHLYEVDEEADKDEDAASLGSQKGGITKQGWLYKGNMNSAISVTMRSFKRRFFHLIQLGDGSYNLNFYKDEKISKEPKGSIFLDSCMGVVQNNKVRRFAFELKMQDKSSYLLAADSELEMEEWINTLNKILQLNFEAAMQEKRNGESHEDDEQSKMESSSSSFDSYYPEITKSTREAEIKLKSESRVKLFALDPDAQKLDFSGIEPEVKPFEEKFGKKILVKCNDLSFNLQSCVAENEEGPTTNVEPFFVTLSLFDIKINRKISADFHVDLNHSSVRHMISSAPQQMMNGSGDGSHRIQDAYETMLQYPKQGIFSVTCPHPDIFLVARIEKVLQGSITHCAEPYMKSSDSAKVAQKVLKNAKQACQRLGQYRMPFAWAARTLFKDASGMLDKNARFSPLFRQDSNKLSNEDMLKLLADFRKPEKMAKLPVILGNLDVTIDNVSPDFPNYVNSSYIPMKQFENSTKTLITFEIEEFVPCIPKHTQPFTIYNNHLYVYPKHLKYDSQKSFAKARNIAVCIEFKDSDEEDSLPLKCIYGRPGGPVFTRSAFAAVLHHHQNPEFYDEIKIELPTQLHEKHHLLFTFYHVSCDNSSKGSTKKKDVVETQVGYSWLPLIKDGRVVTNDQHIPVSANLPSGYLSYQESGVGKHSGPEIKWVDGGKQLLKISTHLVSTVYTQDQHLHNFFQYCQKTESGARALGTELVKYLKSLHAMEGHVMIAFLPTVLNQLFRVLTRATQEEVAVNVTRVIIHIVAQCHEEGLDSYLRSYVKYAYKAEPYVASEYKTVHEELTKSMTTILKPSADFLTSNKLLKYSWFFFEVLIKSMAQHLIENSKVKLLRNQRFSASFHHAVETVVNMLMPHITQKYRDNPEASKNANHSLAAFIKRCFTFMDRGFVFKQINNYISCFAPGDPKTLFEFKFEFLRVVCNHEHYIPLNLPMPFGKGRVQRYQDLQLDYSLTDEFCKNHFLVGLLLREVGNALQEFREVRQIAISVLKNLMIKHSFDDRYASRLHQARIATMYLPLFGLLIENVQRINVKDVSPFPVNPSSNSAKDDGLNLPTANQLVTPQKTVNTLDNNLPKDLFGVISGIASPYTTSTPNINCVRNADSRGSLISTDSGNSLPERHSDKSNSLEKNQQSSTLGSSVVRYDKLDQAEIKSLLMCFLHILRSMSEDALFTYWNKATKSELMDFFTITEVCLHQFQYMGKRYIARNQEGLGSIVHDRKSQTLPVSRNRTGMMHARLQQLSSLDNSLTFNHSYGHSDADVLHQSLLEANTATEVCLTILDTLSLFTMAFKNQLLTDLGHNPLMKKVFDVYLCFLQKNQSETALKHVFIALRALIFKFPSTFYEGRADMCSALCYEILKYCNSKLSSIRTEASQLLYFLMRNNFDYTGKKSFVRTHLQVIISVSQLIADVVGIGGTRFQQSLSIINNCANHDRIIKHTTFPSDVKDLTKRIRTVLMATAQMKEHENDPEMLVDLQYSLAKSYASTPELRKTWLDSMARIHVKNGDLSEAAMCYVHVAALVAEYLTRKGMFRQGCIAFRVITPNIDEEASMMEDVGMQDVHFNEDVLMELLEQCADGLWKAERYELIADIYKLIIPIYEKRRDFERLAHLYDTLHRAYSKVTEVMHTGKRLLGTYFRVAFFGQGFFEDEDGKEYIYKEPKLTPLSEISQRLQKLYSDKFGSENVKMIQDSGKVNPKDLDSKYAYIQVTHVVPYFEEKELQERKTDFERTHNIRRFMFEMPFTQAGKRQGGVEEQCKRRTILTAIHCFPYVKKRIPVMYQHHTDLNPIEVAIDEMSKKVAELRQLCASAEVDMIKLQLKLQGSVSVQVNAGPLAYARAFLDDTNTKRYPDNKVKLLKEVFRQFVEACGHALGVNERLIKEDQLEYQEEMKANYREMAKELSEIMHEQITPVEEKANVMPNSLHIFNAISGTPTSTTVHGMPSSSSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UAD6</accession>
    <name>A0A8C2UAD6_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Mediator complex subunit 12L</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">MED12L</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 12 family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSCJPT00005032387.1">
        <property type="protein sequence ID" value="ENSCJPP00005023660.1"/>
        <property type="gene ID" value="ENSCJPG00005018213.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00440000037505"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051647">
        <property type="entry name" value="Mediator_comp_sub12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019035">
        <property type="entry name" value="Mediator_Med12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021989">
        <property type="entry name" value="Mediator_Med12_catenin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021990">
        <property type="entry name" value="Mediator_Med12_LCEWAV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46007">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46007:SF3">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09497">
        <property type="entry name" value="Med12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12145">
        <property type="entry name" value="Med12-LCEWAV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12144">
        <property type="entry name" value="Med12-PQL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01281">
        <property type="entry name" value="Med12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit Med12" evidence="9">
        <location>
            <begin position="101"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1472"/>
            <end position="1496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1757"/>
            <end position="1834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2064"/>
            <end position="2086"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1472"/>
            <end position="1491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1782"/>
            <end position="1803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1804"/>
            <end position="1813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="2064"/>
            <end position="2075"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005023660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="2138" mass="238612" checksum="F3CFF0925D37C057" modified="2022-01-19" version="1">MAAFGLLSYEQRPLKRPRLGPPDVYPQDPRQKEDELTAVNVKQGFSNQPAFSGDEHGTARNIVINASKIGAYFSSILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQSAIHNWFTDLAGSKPLTVLAKKVPILSKKEDVFAYLAKYSVPLLRAAWLIKMTCAYYAAISEAKIKKRQATDPNIEWTQIITRYLREQLAKVAEFYHVTSSQGSSSVGMPQEMEQALKQWEYNEKLSFYMFQEGMLERHEYLTWILDVLEKIRPTDDDILKLVLPLMLQYSEEFVQSAYLSRRLAYFCARRLSLLLSDGPSLAAAHSPHVIIAPSNPPLAAPSPTAPGPVLSPVQLSCSDFLSCPQHRPLVYGLSCMLQTITLCCPSALVWNYSTNENKNINPGSPLDLLQVAPSSLPMPGGNSTFNQQVRAKISEVEQQIKQRGRAVEVRWSFDKCQESTAGVTISRVLHTLEVLDRHCFDRSDSSNSMETLYHKIFWANQNRDNQEAAPSDEAVVMLLCEWAVSCKRSGKHRAMVVAKLLEKRQAEIEAERCGESEVLDEKESLSSASLTSSSLPVFQNVLLRFLDTQAPSLSDPSSDREKTEFVNLVLLFSEFTRHDVFSHDAYMCTLISRGDLSITATSRPRSPNGETVDEHYSKDHDVKMEDHSIMEHMGTDSGPTCIFDDVDKGDFKADFGSEFPIFSPMPGESCENMNSSLDRRISVASEKSVKREGLREVIFPSNYDLLRHLQYATHFPIPLDESSSHECNQRMILLYGVGKERDEARHQLKKITKDILKILNKKSTTEMGVGDEGQKARKNKQEAFPTLETVLTKLQQLSYFDQHQVTSQISTNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPALNINGLIDFAIQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHACLILNAEQTAQVFEGLCGVVKHVVNPSECSSPERCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQTIYSNVQPSNSNLLWDPEFMLDFIENPSAHSINYSMLGKILSDNAANRYSFVCNALMNVCMGHQDAGRINDIANLCAELTACCTVLSSEWLGVVKALCCSSNHVWGFNDLLCSVDVSDLSFHDSLATFIAILIARQCFSLEDVVQHVALPSLLAAACGDPDAEPGARMTCRLLLHLFRTPQVCLFPQGAGKLFPGIRSSCDRHLLAAAHNSIEVGAVFAVLKAILMLGDAEIGSSSVTPVKNEELPVRGLLDEVPEDEMWASSHALKSRGKSVSIETASLSEYARYVLRTICQQEWVGEHCLKEPERLCTDKDLILDPVLSNKQAQKLLQLICYPHGVKECSEGDNPQRQHIKRILQNLDQWTLRQSWLELQLMIKQCMKEPGSGSVAEMNSLLDNIAKATIEVFQQSADLNNNSSNSGIGLFNPNSVGNADTSNTRQNGKKTFLSSSEWRGVWLVAPLIAKLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERYQGDVKARQMMHEALQLRLNLVGGMFDTVQRSTQWTTDWALLLLQIITSGTVDMQTNNELFTTVLDMLGVLINGTLASDLSNASQGGPEENKRAYMNLVKKLKKELGDKRSDSIDKVRQLLPLPKQTCDIITCEPMGSLIDTKGNKIAGFDSIDKKQGLQVSTKQKVSPWDLFEGHKNPAPLSWAWFGTVRVDRKVIKYEEQQHLLLYHAHPKPKPRSYYLEPLPLPPEEEEEEPTTPVSQEPERKPGELSDQGKHTTDDEKKTKGRKRKSKSSSKADEYPQNNLYRVPPNYSPIPSQMMQHPQSALWGYTIMGHPQQPGFFMQNQPLPPGGSRLDPTSSFMPANTKQALSNMLQRRSGTVLQPPALHAVTPQQQLLQMKLLQQEQQQQQRLLRHQAQARSLQQAQPMDPAALFTPQVRPTPQLPQYPGLQQAQSMPHGYTMYSTPMPLQQQPGSVVLSPGYDPRTYTAHSSPMLMERLRPGQPGSVAQQQAAAYMQPLAGAQRLTHQPLQPNSLMGAGLDSAATTRTHPSLSSAQLPQEEMRQRQQQIRQQRLFQVRNPTAPKAGGASLQGVCATFCGPLELFPCFHSNAMAICARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UAF4</accession>
    <name>A0A8C2UAF4_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Clustered mitochondria protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">CLUH</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria. Specifically binds mRNAs of nuclear-encoded mitochondrial proteins in the cytoplasm and regulates transport or translation of these transcripts close to mitochondria, playing a role in mitochondrial biogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasmic granule</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CLU family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015736638.1">
        <property type="nucleotide sequence ID" value="XM_015881152.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005033124.1">
        <property type="protein sequence ID" value="ENSCJPP00005024283.1"/>
        <property type="gene ID" value="ENSCJPG00005019171.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107322769"/>
    <dbReference type="CTD" id="23277"/>
    <dbReference type="GeneTree" id="ENSGT00390000012485"/>
    <dbReference type="OrthoDB" id="1414216at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd15466">
        <property type="entry name" value="CLU-central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000088">
        <property type="entry name" value="Clustered mitochondria (CluA/CLU1) homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2280.10:FF:000001">
        <property type="entry name" value="Clustered mitochondria (CluA/CLU1) homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2280.10">
        <property type="entry name" value="Hypothetical protein (hspc210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03013">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033646">
        <property type="entry name" value="CLU-central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025697">
        <property type="entry name" value="CLU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028275">
        <property type="entry name" value="CLU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027523">
        <property type="entry name" value="CLU_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023231">
        <property type="entry name" value="GSKIP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601:SF6">
        <property type="entry name" value="CLUSTERED MITOCHONDRIA PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT EIF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13236">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15044">
        <property type="entry name" value="CLU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12807">
        <property type="entry name" value="eIF3_p135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103107">
        <property type="entry name" value="Hypothetical protein c14orf129, hspc210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51823">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Clu" evidence="6">
        <location>
            <begin position="378"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="210"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="680"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1306"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="55"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="680"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="697"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1306"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1320"/>
            <end position="1331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005024283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1346" mass="151402" checksum="3CE2B3C83353D8ED" modified="2022-01-19" version="1">MVSKADEMPPAAVPASAQGGEQQEPGPRGRREAEAEQRPEHPPGVALVNGSGPHESLKGEKDARQNGHEEADTGEDGNDQEVIVIQDTGFTVKICAPGIEPFSLQVSPQEMVQEIHQVLMDREDTCHRTCFSLQLDGNVLDNFAELKTIEGLQEGSLLKVVEEPYTVREARIHVRHIRDLLKSLDPSDAFNGVDCNSLSFLSVFTEGDLGDSGKRKKKGTEMEQIDCTPPEHILPGSKERPLCALQPQNRDWKPLQCLKVLTMSGWNPPPGNRKMHGDLMYLYVITVEDRHVSITASTRGFYLNQSTAYNFNPKPANPSFLSHSLVELLNQISPTFKKNFSALQKKRVQRHPFERIATPFQVYSWTAPQAEHAMDCVRAEDAYTSRLGYEEHIPGQTRDWNEELQTTRELPRKNLPERLLRERAIFKVHSDFTAAATRGAMAVIDGNVMAINPSEETKMQMFIWNNIFFSLGFDVRDHYKDFGGDVAAYVAPTNDLNGVRTYNAVDVEGLYTLGTVVVDYRGYRVTAQSIIPGILEREQEQSVIYGSIDFGKTVVSHPKYLELLEKTSRPLKIQKHKVLNDKNEEVELCSSVECKGIIGNDGRHYILDLLRTFPPDLNFLPVEGEEMPEECKKMGFPKQHRHKLCCLRQELVDAFVEHRYLLFMKLAALQLMQQKANKQESSAALENGTSPENGTAESEKSESDDGKTDDNMTGLDQVKELAETIASDDGTVDPKSREVIRNACKAVGSISDTSFDIRFNPDIFSPGVRFPESSKEEVQDQKQLLKDAAAFLLSCQIPGLVKDCLDHTVLPMDGATLAEAMHQRGINMRYLGKVIHFITKTPGHAQLDHIFKIGISELITRSAKHIFKTYLQGVELSGLSAAISHFLNCFLSSFPNPIAHLPADELASKKKNKKRKNRNLGNADNTAWASMTPQELWKNICSEAKSYFDFSLECENADQAAEMYNLQKITLLREISLKTGVQILLKEYNFDNRHKPTFTEEDILNIFPVVKHVNPKASDAFHFFQSGQAKVQQGFLKEGCELINEALNLFNNVYGAMHVEICACLRLLARLNYIMGDYSEALSNQQKAVLMSERVLGIEHPNTIQEYMHLALYCFANSQLSTALNLLYRARYLMLLVFGEDHPEMALLDNNIGLVLHGVMEYDLSLRFLENALAISSKYHGSKSLKVALSHHLVARVYESKAEFRSALQHEKEGYTIYKNQLGEHHEKTKESSEYLKYLTQQAVALQRTMNEIYKNGSNANIMPLKFTAPNMTSVLEQLNIINGILFIPLSQKDLENLKAEVQRRQQLQENTKSGEQLEPEDRAGEEKEAEPSMPSAAIPLTQSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UAR2</accession>
    <name>A0A8C2UAR2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Polypeptide N-acetylgalactosaminyltransferase</fullName>
            <ecNumber evidence="18">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Protein-UDP acetylgalactosaminyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">GALNT9</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Does not glycosylate apomucin or SDC3.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 18">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 18">Golgi apparatus membrane</location>
            <topology evidence="2 18">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="18"/>
    <dbReference type="RefSeq" id="XP_015733146.1">
        <property type="nucleotide sequence ID" value="XM_015877660.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UAR2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005033270.1">
        <property type="protein sequence ID" value="ENSCJPP00005024403.1"/>
        <property type="gene ID" value="ENSCJPG00005019234.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107321089"/>
    <dbReference type="KEGG" id="cjo:107321089"/>
    <dbReference type="CTD" id="50614"/>
    <dbReference type="GeneTree" id="ENSGT00940000156599"/>
    <dbReference type="OrthoDB" id="9924649at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004653">
        <property type="term" value="F:polypeptide N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23473">
        <property type="entry name" value="beta-trefoil_Ricin_GALNT9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02510">
        <property type="entry name" value="pp-GalNAc-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000025">
        <property type="entry name" value="Polypeptide N-acetylgalactosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000192">
        <property type="entry name" value="Polypeptide N-acetylgalactosaminyltransferase 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000203">
        <property type="entry name" value="Polypeptide N-acetylgalactosaminyltransferase 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045885">
        <property type="entry name" value="GalNAc-T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675:SF28">
        <property type="entry name" value="POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 18" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12 18" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 18" id="KW-0430">Lectin</keyword>
    <keyword evidence="16 18" id="KW-0464">Manganese</keyword>
    <keyword evidence="13 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="19">
        <location>
            <begin position="466"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00057231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU361242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005024403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="604" mass="68797" checksum="2696D937880E9A36" modified="2022-01-19" version="1">MAVARKIKTLLTVNILVFVGIILFSVYCRIQDRSQELVQIVRSADRRVRSRGAKVGSLADRESILQRLDHLEEVVYNQLNGLAKPMGLVEGPGGLGQGGMAATLRDDSHESETKYEEYGYNAQLSDRISLDRSIPDYRPKKCKQMTYPDDLPQISVVFIFVNEALSVILRSVHSVVNHTPSHLLKEIILVDDNSDNVELKFNLDQYVNKRYPGLVKIVRNNKREGLIRARIQGWKAATSPVVGFFDAHVEFNIGWVEPALTRIKEDRKRIILPAIDNIKYNTFEVQQYANAAHGYNWGLWCMYIIPPQDWLDKGDESAPIRTPAMIGCSFVVDREYFGEIGLLDPGMEVYGGENIELGMRVWQCGGSMEVLPCSRVAHIERTKKPYNNDIDYYAKRNALRAAEVWMDDFKSHVYMAWNIPMANPGVDFGDVSERIALRQRLQCRSFKWYLENVYPEMRVYNNTVTYGEVRNSKASGYCLDQGAEEDDKAILYPCHGMSSQLVRYSSDGVLQLGPLGSTAFLPDSKCLVDDGKGRTPTLKKCEDVLRPAQRFWDFTQNGPIISRDTGRCLEVEMSKDANFGLRLVVQRCSGQKWMIRNWIKHGRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UAX1</accession>
    <name>A0A8C2UAX1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">unspecific monooxygenase</fullName>
            <ecNumber evidence="5">1.14.14.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC107315856</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.1" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2UAX1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005032606.1">
        <property type="protein sequence ID" value="ENSCJPP00005023864.1"/>
        <property type="gene ID" value="ENSCJPG00005018857.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155736"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008392">
        <property type="term" value="F:arachidonate epoxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019373">
        <property type="term" value="P:epoxygenase P450 pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20665">
        <property type="entry name" value="CYP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000238">
        <property type="entry name" value="Cytochrome P450 2A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF356">
        <property type="entry name" value="CYTOCHROME P450 2E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 14 15" id="KW-0349">Heme</keyword>
    <keyword evidence="11 14 15" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12 15" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="438"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005023864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="493" mass="56896" checksum="B56A4684F817C30D" modified="2022-01-19" version="1">MQLHRSRDWCKREETFCLSLWCTICKYYLRKSKNNIQMKLQISYSTIDIQLCCSLCSSSLQISKKYGPIFTIHLGPKKAVVLYGYDIVKEALIDNGEAFSGRGNLPLFEKVFKGTGIVTSNGETWRQLRRFALTTLRDYGMGKKGIEERIQEEAHFLVERIRNTHEKPFNPVTFLMHGVSNIICSVVFGDRFEYEDKKFLDLIEMLEENEKHQNSIQTQLYNFFPTILDYLPGPHIKLIKSVDKVDAFISEIIRAHQESFDPSCPRDFIDAFINKMQQEKGNSHFTVESLTRTTIDLFLAGTGTTSTTLRYAFLILLKHPEVEEKIHKEIDRVVGRDRSPCMADRSQMPYTDAVIHEIQRFIDFIPVNLPRAVTKDTILRGYFIPKDTMVFPLLSPILQDHKEFPNPEKFDPGHFLNANGTFRKSNYFLPFSTGKRICAGEGLARMEIFLFLTTILQNFTLKPVVDRKDIDISPIVTSVSNIPPPYEVSFIPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UBB1</accession>
    <name>A0A8C2UBB1_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Zygote arrest 1 like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ZAR1L</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">mRNA-binding protein required for maternal mRNA storage, translation and degradation during oocyte maturation. Probably promotes formation of some phase-separated membraneless compartment that stores maternal mRNAs in oocytes: acts by undergoing liquid-liquid phase separation upon binding to maternal mRNAs. Binds to the 3'-UTR of maternal mRNAs, inhibiting their translation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoplasmic ribonucleoprotein granule</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ZAR1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015707508.1">
        <property type="nucleotide sequence ID" value="XM_015852022.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UBB1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005035480.1">
        <property type="protein sequence ID" value="ENSCJPP00005026174.1"/>
        <property type="gene ID" value="ENSCJPG00005020414.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107308261"/>
    <dbReference type="KEGG" id="cjo:107308261"/>
    <dbReference type="CTD" id="646799"/>
    <dbReference type="GeneTree" id="ENSGT00390000012305"/>
    <dbReference type="OrthoDB" id="9885288at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036464">
        <property type="term" value="C:cytoplasmic ribonucleoprotein granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001556">
        <property type="term" value="P:oocyte maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026775">
        <property type="entry name" value="Zar1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027377">
        <property type="entry name" value="ZAR1/RTP1-5-like_Znf-3CxxC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31054:SF5">
        <property type="entry name" value="PROTEIN ZAR1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31054">
        <property type="entry name" value="ZYGOTE ARREST PROTEIN 1-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13695">
        <property type="entry name" value="Zn_ribbon_3CxxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01328">
        <property type="entry name" value="zf-3CxxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6" id="KW-0221">Differentiation</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0896">Oogenesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="3CxxC-type" evidence="13">
        <location>
            <begin position="196"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="13"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="144"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="13"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="153"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005026174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="295" mass="32845" checksum="4A1157D4AA80F91B" modified="2022-01-19" version="1">MESFVFPPFGSFQSFRGSLTPSRSGELTPKQPSWKQSKGSVLSPFPVGPPTPVSADYLDTCRRAQLKALLSQVSPGLTPRLCRANTKEVGVQVNPRTDVAVQCSLGPRTLPAGRPLTPAAARGRLAVYSPLMNPRLFTLPEAHQEEEAAATPEEQKAEGGSDEQRDGSAEAAAPSETPREPSAAPGRRAAFQFLEQKYGYFHCKDCKTRWESAYVWCISGSNKVYFKQLCRKCQKGFNPYRVEAIQCQTCFKTRCTCPQKKRHIDLTRPHRQELCGRCKGKRLSCDNTYSFKYIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UE70</accession>
    <name>A0A8C2UE70_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Solute carrier family 49 member 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">SLC49A4</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Mediates H(+)-dependent pyridoxine transport.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>pyridoxine(out) + n H(+)(out) = pyridoxine(in) + n H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:76203"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16709"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015724167.1">
        <property type="nucleotide sequence ID" value="XM_015868681.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UE70"/>
    <dbReference type="Ensembl" id="ENSCJPT00005036771.1">
        <property type="protein sequence ID" value="ENSCJPP00005027152.1"/>
        <property type="gene ID" value="ENSCJPG00005021076.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107316795"/>
    <dbReference type="KEGG" id="cjo:107316795"/>
    <dbReference type="CTD" id="84925"/>
    <dbReference type="GeneTree" id="ENSGT01030000234625"/>
    <dbReference type="OrthoDB" id="422206at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031923">
        <property type="term" value="P:pyridoxine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd17397">
        <property type="entry name" value="MFS_DIRC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000162">
        <property type="entry name" value="disrupted in renal carcinoma protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049680">
        <property type="entry name" value="FLVCR1-2_SLC49-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049604">
        <property type="entry name" value="SLC49A4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924:SF27">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 49 MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0458">Lysosome</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="197"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="329"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="358"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="390"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005027152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="488" mass="53461" checksum="01373E1BC074BA41" modified="2022-01-19" version="1">MGLGWSSEEERQPLLRPPPPPQAAQQRRPQPRGTAGGPALPVPVPVRRLAPAAGRVYGRRWLVLLLFSLLGFSQGLVWNSWGPIQNSARLAFGFSGWDIALLVFWGPIGFVPCFFFMWLMDKKGLRVTVLLTSSLMVLGAGLRCVPVSDLELRKKLIHGGQLLNGLAGPTVMNAAPFLSTTWFSPDERATATAIASLLNYLGCAGAFLVGPLVVPSPNGTSHLPLLSQSNTEHIKDRIEAVLYAEFGMVSLIFSAALAYFPSRPPFPPSVAAASQRLSYRRSFCRLLSNFRFLMIALAYAIPLGVFSGWSGVLDLILTPVHVSQVDAGWIGFWSIVGGCVVGIAMARFADFIRGMLKFILLLLLSGATLASTWFTLTCLTSVTHLPLTTATLYTSCILLGIFLNSSVPIFFELFVETVYPVPEGITCGVVTFLSNVFMGVLLFFLTFYHTEFSWFNWCLPGSCLLSLLLILCFRESYDRLYLDVVVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UE91</accession>
    <name>A0A8C2UE91_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Calcium binding protein 39 like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">CAB39L</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Mo25 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015707310.1">
        <property type="nucleotide sequence ID" value="XM_015851824.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015707311.1">
        <property type="nucleotide sequence ID" value="XM_015851825.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015707312.1">
        <property type="nucleotide sequence ID" value="XM_015851826.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UE91"/>
    <dbReference type="SMR" id="A0A8C2UE91"/>
    <dbReference type="Ensembl" id="ENSCJPT00005034282.1">
        <property type="protein sequence ID" value="ENSCJPP00005025183.1"/>
        <property type="gene ID" value="ENSCJPG00005019787.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005034283.1">
        <property type="protein sequence ID" value="ENSCJPP00005025184.1"/>
        <property type="gene ID" value="ENSCJPG00005019787.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107308160"/>
    <dbReference type="KEGG" id="cjo:107308160"/>
    <dbReference type="CTD" id="81617"/>
    <dbReference type="GeneTree" id="ENSGT00390000004360"/>
    <dbReference type="OrthoDB" id="609103at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000025">
        <property type="entry name" value="Calcium-binding protein 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013878">
        <property type="entry name" value="Mo25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10182:SF9">
        <property type="entry name" value="CALCIUM-BINDING PROTEIN 39-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10182">
        <property type="entry name" value="CALCIUM-BINDING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08569">
        <property type="entry name" value="Mo25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="15"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005025184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="334" mass="38869" checksum="C4EC4A79371CC45D" modified="2022-01-19" version="1">MPLFSKSHKNPAEIVKILKENMAILEKQEKKTDKASEEVSKSLQAMKEILCGTTDKEPPTEVVAQLAQELYNSGLLVTLIANLQLIDFEGKKDVSQIFNNILRRQIGTRSPTVEYISAHPHILFMLLKGYESPNIALRCGIMLRECIRHEPLAKIILFSEQFRDFFKYVEMSTFDIASDAFATFKDLLTRHKLLVADFMEQNYDTIFEDYEKLLHSENYVTKRQSLKLLGELILDRHNFAIMTKYISKPENLKLMMNLLRDKSPNIQFEAFHVFKVFVASPNKTQPIVEILLKNQPKLIEFLSNFQKERTDDEQFTDEKNYLIKQIRDLKKPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UEG2</accession>
    <name>A0A8C2UEG2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">BMP/retinoic acid-inducible neural-specific protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BRINP1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BRINP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015734860.1">
        <property type="nucleotide sequence ID" value="XM_015879374.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UEG2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005034381.1">
        <property type="protein sequence ID" value="ENSCJPP00005025256.1"/>
        <property type="gene ID" value="ENSCJPG00005019845.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107321912"/>
    <dbReference type="KEGG" id="cjo:107321912"/>
    <dbReference type="CTD" id="1620"/>
    <dbReference type="GeneTree" id="ENSGT00940000158084"/>
    <dbReference type="OrthoDB" id="8503728at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001662">
        <property type="term" value="P:behavioral fear response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008283">
        <property type="term" value="P:cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071300">
        <property type="term" value="P:cellular response to retinoic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021954">
        <property type="term" value="P:central nervous system neuron development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035640">
        <property type="term" value="P:exploration behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048873">
        <property type="term" value="P:homeostasis of number of cells within a tissue"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042711">
        <property type="term" value="P:maternal behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045930">
        <property type="term" value="P:negative regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050768">
        <property type="term" value="P:negative regulation of neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045666">
        <property type="term" value="P:positive regulation of neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007614">
        <property type="term" value="P:short-term memory"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035176">
        <property type="term" value="P:social behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071625">
        <property type="term" value="P:vocalization behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033237">
        <property type="entry name" value="BRINP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057671">
        <property type="entry name" value="BRINP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057450">
        <property type="entry name" value="BRINP_EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020864">
        <property type="entry name" value="MACPF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15564:SF7">
        <property type="entry name" value="BMP_RETINOIC ACID-INDUCIBLE NEURAL-SPECIFIC PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15564">
        <property type="entry name" value="MACPF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19052">
        <property type="entry name" value="BRINP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25415">
        <property type="entry name" value="EGF_BRNP1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01823">
        <property type="entry name" value="MACPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00457">
        <property type="entry name" value="MACPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0338">Growth arrest</keyword>
    <keyword evidence="6" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034146807" description="BMP/retinoic acid-inducible neural-specific protein 1" evidence="10">
        <location>
            <begin position="21"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="domain" description="MACPF" evidence="11">
        <location>
            <begin position="72"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005025256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="761" mass="88762" checksum="A02E87CA7F58C5FB" modified="2022-01-19" version="1">MNWRLVEFLYLLFIWDHILVQPSHQDPAATNQHVSKEFDWLISDRGPFHHSRSYLSFVERHRQGFTTRYKIYREFARWKVRNTAIERRDLLHNPLPLMPEFQRSIRLLGRRPTTQQFIDTIIKKYGTHILISATLGGEEALTMYMDKSRLDRKSGNATQSVEALHQLASSYFVDRDGTMRRLHEIQISTGAIKVTETRTGPLGCNSYDNLDSVSSVLLQSTESKLHLQGLQIIFPQYLQEKFVQSALSYIMCNGEGEYICRNSQCGCQCAEEFPQCNCPITDIQIMEYTLANMGKTWTEAYKDLENSDEFKSFMKRLPSNHFLTIASIHQHWGNDWDLQNRYKLLQSSLEAQRQKIQRTARKLFGLSVRCRHNPNHQLPRERTIQEWLTRVQSLLYCNENGFWGTFLESQRSCVCHGGTSLCQRPIPCIIGGNNSCAMCSLANISLCGSCNKGYKLYRGRCEPQNVDSERSEQFISFETDLDFQDLELKYLLQKMDSRLYVHTTFISNEIRLDTFFDPRWRKRMSLTLKSNKNRMDFIHMVIGISMRICQMRNSSLDPMFFVYVNPFSGSHSEGWNMPFGEYGYPRWEKIRLQNSQCYNWTLLLGNRWKTFFETVHIYLRSRTRLPSLLRNETGQGPVDLSDPSKRQFYIKISDVQVFGYSLRFNADLLRSAVQQVNQSYTQGGQFYSSSSVMLLLLDIRDRINRLAPPVAPGKPQLDLFSCMLKHRLKLTNSEIIRVNHALDLYNTEILKQSDQMTAKLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UFA4</accession>
    <name>A0A8C2UFA4_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SECIS binding protein 2 like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">SECISBP2L</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UFA4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005034688.1">
        <property type="protein sequence ID" value="ENSCJPP00005025517.1"/>
        <property type="gene ID" value="ENSCJPG00005019956.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00490000043356"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035368">
        <property type="term" value="F:selenocysteine insertion sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001514">
        <property type="term" value="P:selenocysteine incorporation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000004">
        <property type="entry name" value="selenocysteine insertion sequence-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040051">
        <property type="entry name" value="SECISBP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13284">
        <property type="entry name" value="GH01354P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13284:SF10">
        <property type="entry name" value="SELENOCYSTEINE INSERTION SEQUENCE-BINDING PROTEIN 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="3">
        <location>
            <begin position="707"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="152"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="241"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="335"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="525"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="611"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="883"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="977"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1032"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="801"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="152"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="196"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="256"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="372"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="612"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="940"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="989"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1041"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1089"/>
            <end position="1099"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005025517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1099" mass="121089" checksum="E0E1F53B43C1D66F" modified="2022-01-19" version="1">VDRQIAENLQNVKLSAEVEPFIPQKKGPETLMIPMALPGDSGGINGVEPAPIPSYLITCYPFVQENQSNRQFPLYNNDIRWQQPNPNPAGPYLAYPIISAQPPVSTEYTYYQLMPAPCAQVMGFYHPFPPPYSAPFQTANAVNTVTTECTERANPSGQVFPISTQRSRSSNRGPVIPKQQQLQMHIKNKRPPVKNVATQKETSSSGPENRSKIVLLVDASQQTDFPSDIANKSLSESASTMLWKSKGRRRRASHPAAESSSEQGASEADIDSDSGYCSPKHGNNQAAAVASRNADSCAMNVCEACNGTGVSWTNVNSQATQKKPWIEKTQTFIRGGRQAEQRNSSQSGFRCRGHSTSSERRQNLQKRHEKPLTTSQSSRAEQSPEPLYFEDEDEFPELNSDNGNSKSSNMQQKISPKVLDDLPENSPINIVQTPIPITTSVPKRAKSQKKKALAAALATAQEYSEISMEQKKLQEALSKAAGKKSKTPVQLDLGDMLAALEKQQQAMKARQITNTRPLSYTVGSAAPFHTKEPTNRKSLTKGQPSMGCLNPLDSTAPKVKRGKEREIAKLKRPTALKKIILKEREEKKGRLSVDHSLLGSDEQKEVHISLPADQSQELASQEETGLSMPSDTSLSPASQNSPYCMTPVSQGSPASSGIGSPMASSAITKIHSKRFREYCNQVLSKEIDECVTLLLQELVSFQERIYQKDPMRAKARRRLVMGLREVTKHMKLNKIKCVIISPNCEKIQSKGGLDEALYNVIAMAREQEIPFVFALGRKALGRCVNKLVPVSVVGIFNYSGAEDLFNKLVSLTEEARKAYRDMVAAMEQEQAEEALKNVKKAPHHMGHSRNPSAASAISFCSVISEPISEVNEKEYETNWRNMVETSDGLETSENERESSSKTAVPEKAGSGQIAKSTLNKQPPLATTSATSATNHGKATLGEKEEVKPDDNLEWASQQSTETGSLDGSCRDILNSSMISTTSTLVPGMLEEEDEEDEEDDEDYAHEPISVEVQLNSRIESWVSETQRTMETLQLGKTLSGAEEDNAEQSEEEEIETSEQVDPAVDSEEWTNDKHASNIQHKPTICGSLNKEHTDSIYMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UGH4</accession>
    <name>A0A8C2UGH4_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Kynurenine formamidase</fullName>
            <shortName evidence="5">KFA</shortName>
            <shortName evidence="5">KFase</shortName>
            <ecNumber evidence="5">3.5.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Arylformamidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">N-formylkynurenine formamidase</fullName>
            <shortName evidence="5">FKF</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">AFMID</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>N-formyl-L-kynurenine + H2O = L-kynurenine + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13009"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:58629"/>
            <dbReference type="EC" id="3.5.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">The main chain amide nitrogen atoms of the second glycine and its adjacent residue in the HGGXW motif define the oxyanion hole, and stabilize the oxyanion that forms during the nucleophilic attack by the catalytic serine during substrate cleavage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the kynurenine formamidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.9" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2UGH4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005036919.1">
        <property type="protein sequence ID" value="ENSCJPP00005027287.1"/>
        <property type="gene ID" value="ENSCJPG00005021173.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000011093"/>
    <dbReference type="UniPathway" id="UPA00333">
        <property type="reaction ID" value="UER00454"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000134">
        <property type="entry name" value="Kynurenine formamidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03014">
        <property type="entry name" value="KFase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049492">
        <property type="entry name" value="BD-FAE-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027519">
        <property type="entry name" value="KFase_ver/fungi-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF33">
        <property type="entry name" value="KYNURENINE FORMAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20434">
        <property type="entry name" value="BD-FAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0823">Tryptophan catabolism</keyword>
    <feature type="domain" description="BD-FAE-like" evidence="7">
        <location>
            <begin position="78"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="HGGXW" evidence="5">
        <location>
            <begin position="97"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005027287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="310" mass="34149" checksum="C9A4829BE619133D" modified="2022-01-19" version="1">MGLEVRGLGRDEAPPVPRVRPRSPCSPVSVFPQELELQYSPSRWSRRMDSETSSARRAQAAARTSLHVPYGDGDREKLDIYFPASSSEAFPVFVYIHGGYWQCLSKDESGFAAPVLLSQGIAVVAMGYDIAPKGHMDAMVLQVRRSLAFLVKQYHRIRGIYLCGHSAGAHLAAMVLSTDWTEFGVVPDIRGAVLVSGVYDLEPLLHTYVNDALNMSLEVAQRNSPILCVTQAVSVAASCEVLVAVAQHDSPEFRRQSQEYSQALRSAGWSVSLLDLASVDHFDIIEKLSEETYVLTQSFTETFFTRGATC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UGI0</accession>
    <name>A0A8C2UGI0_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutaredoxin and cysteine rich domain containing 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">GRXCR2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015730947.1">
        <property type="nucleotide sequence ID" value="XM_015875461.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UGI0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005036430.1">
        <property type="protein sequence ID" value="ENSCJPP00005026901.1"/>
        <property type="gene ID" value="ENSCJPG00005020889.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107320028"/>
    <dbReference type="KEGG" id="cjo:107320028"/>
    <dbReference type="CTD" id="643226"/>
    <dbReference type="GeneTree" id="ENSGT00940000158849"/>
    <dbReference type="OrthoDB" id="423313at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005902">
        <property type="term" value="C:microvillus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120044">
        <property type="term" value="C:stereocilium base"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120043">
        <property type="term" value="C:stereocilium shaft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060088">
        <property type="term" value="P:auditory receptor cell stereocilium organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007605">
        <property type="term" value="P:sensory perception of sound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033023">
        <property type="entry name" value="GRXCR2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46926">
        <property type="entry name" value="GLUTAREDOXIN DOMAIN-CONTAINING CYSTEINE-RICH PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46926:SF1">
        <property type="entry name" value="GLUTAREDOXIN DOMAIN-CONTAINING CYSTEINE-RICH PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005026901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="225" mass="24860" checksum="F5C02CB57A16230A" modified="2022-01-19" version="1">MDEPQRNPGQRPEGRPRKVRFRISSACSGRVLKQVYEDGQALEPPTVEQSRRLRHSFEPAVLPDGPALGLPQSSGCGEDGRSPGCPPAGSGLYGASPVIDFGQIIIYTNNLKIIRAPMDQRELMRRIIQTEGVSDWAFVYRERRERIGAGHRKDVEKKAVCNQYMQERGAERTCSQCKGSGCAPCSLCHGSKFSMLANRFKESYRALRCPACNESGVQPCQVCAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UJA1</accession>
    <name>A0A8C2UJA1_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Crumbs cell polarity complex component 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">CRB1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSCJPT00005036849.1">
        <property type="protein sequence ID" value="ENSCJPP00005027226.1"/>
        <property type="gene ID" value="ENSCJPG00005021121.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155152"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045177">
        <property type="term" value="C:apical part of cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097386">
        <property type="term" value="C:glial cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005902">
        <property type="term" value="C:microvillus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001750">
        <property type="term" value="C:photoreceptor outer segment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035003">
        <property type="term" value="C:subapical complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001974">
        <property type="term" value="P:blood vessel remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062139">
        <property type="term" value="P:camera-type eye photoreceptor cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007154">
        <property type="term" value="P:cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071482">
        <property type="term" value="P:cellular response to light stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050908">
        <property type="term" value="P:detection of light stimulus involved in visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030855">
        <property type="term" value="P:epithelial cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061159">
        <property type="term" value="P:establishment of bipolar cell polarity involved in cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010001">
        <property type="term" value="P:glial cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UJV7</accession>
    <name>A0A8C2UJV7_COTJA</name>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="30" type="primary">GRIN2C</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="30" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="30" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="30" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="26">Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>Na(+)(in) = Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:34963"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="18 26">Postsynaptic cell membrane</location>
            <topology evidence="18 26">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="22">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR2C/GRIN2C subfamily.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSCJPT00005037584.1">
        <property type="protein sequence ID" value="ENSCJPP00005027864.1"/>
        <property type="gene ID" value="ENSCJPG00005021542.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156964"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017146">
        <property type="term" value="C:NMDA selective glutamate receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098839">
        <property type="term" value="C:postsynaptic density membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005261">
        <property type="term" value="F:monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004972">
        <property type="term" value="F:NMDA glutamate receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904315">
        <property type="term" value="F:transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097553">
        <property type="term" value="P:calcium ion transmembrane import into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033058">
        <property type="term" value="P:directional locomotion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060079">
        <property type="term" value="P:excitatory postsynaptic potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042177">
        <property type="term" value="P:negative regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050885">
        <property type="term" value="P:neuromuscular process controlling balance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903539">
        <property type="term" value="P:protein localization to postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048167">
        <property type="term" value="P:regulation of synaptic plasticity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009611">
        <property type="term" value="P:response to wounding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd06378">
        <property type="entry name" value="PBP1_iGluR_NMDA_NR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13718">
        <property type="entry name" value="PBP2_iGluR_NMDA_Nr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000026">
        <property type="entry name" value="Glutamate ionotropic receptor NMDA type subunit 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000020">
        <property type="entry name" value="Glutamate receptor ionotropic, NMDA 2B, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000007">
        <property type="entry name" value="Putative glutamate receptor ionotropic NMDA 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001508">
        <property type="entry name" value="Iono_Glu_rcpt_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00177">
        <property type="entry name" value="NMDARECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="2 26" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12 25" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="17 26" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10 26" id="KW-0406">Ion transport</keyword>
    <keyword evidence="16 26" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 26" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15 26" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="13 26" id="KW-0675">Receptor</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 26" id="KW-0732">Signal</keyword>
    <keyword evidence="9 26" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 26" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 26" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 26" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="26">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034800821" description="Glutamate receptor" evidence="26">
        <location>
            <begin position="20"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="555"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="599"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="628"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="817"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="28">
        <location>
            <begin position="443"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="29">
        <location>
            <begin position="449"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="1021"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="1138"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="1187"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="1303"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="27">
        <location>
            <begin position="1206"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="27">
        <location>
            <begin position="1219"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="512"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="517"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="688"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="689"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="730"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="site" description="Crucial to convey clamshell closure to channel opening" evidence="24">
        <location>
            <position position="661"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with the cone snail toxin Con-ikot-ikot" evidence="24">
        <location>
            <position position="694"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="744"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00036239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00060923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="RuleBase" id="RU367118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005027864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1370" mass="149178" checksum="51852C2E3D8EF957" modified="2022-01-19" version="1">MGRAPAHTLLLSLVLGCSAAFTDVLLPGPAEPVVNVAVVFGGTSYPLHIRSRLSPQSFLDMPLEIHPITVIVNNTNPSTLLTHICNVLATHKIHGIVFEDNVGTEAVAQILDFISSQTQVPIISISGGSAVVLSPKEPSSAFLQLGVSIEQQIQVIFKVLEEYDWSSFAVITSLYPGYNIFLELIRSFTDASYFGWELQDVLTFEMSQERSSSRTQRLLRQLDAQVLLVYCSRDEAEFLFEMAGQAGLVGPGYIWIVPSLTVGNMEQPPTSFPIGLISVVTESWKLSLRQKVRDGVAIIAMGAASFFRAHGFLPDVGRDCRAPTAAANASFYRHLLNVTWEHRDFSFNEGGYLVRPTMVVISLNQHRLWEMVGKWEHGIIHMKYPVWPRYGSFLQPVVDNRHLTVATLEERPFVIVENTDPGTGVCVRNTVPCRKQSNASASSDGLADPYTKLCCKGFCIDILKKLAKTVKFSYDLYLVTNGKHGKIVRGVWNGMIGEVYYKRADMAIGSLTINEERSEIVDFSVPFVETGISVMVARSNGTVSPSAFLEPYSPAVWVMMFVMCLTVVAVTVFVFEYFSPVGYNQNLTSGKRPGGPTFTIGKSVWLLWALVFNNSVPIENPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEQYIDTVSGLSDRKFQKPQEQYPPFRFGTVPNGSTERNIRSNYPDMHTHMVKYNQRSVEDALTSLKMGKLDAFIYDAAVLNYMAGKDEGCKLVTIGSGKVFATTGYGIALQKDSRWKRAIDLALLQFLGDGETQKLETVWLSGICQNEKNEVMSSKLDIDNMAGVFYMLLVAMGLSLLVFAWEHLVYWKLRHSVPKSHKFDFLLAISRVCTTPWGAARGHPLGSAGSVWCGEMLGDRRRSMVGMGLCQRLPLPSPPAMSAHGGAVCVAPRSADGAMSPLSLQGIYSCFSGVQTLGSPGRTPTPDVTASSAQANVLKMLQAAKDMVSTASVGGSLEHATRTIEDWSSRSEHLQTTFSLRTPQLVVQNSTGTHRAPSCGPPHPERLRGAHAPKGPPRGLHLPIPVDSREERWGGTSERSPRVLHPVKFRGCDAADGAVPGPFPHLPAPDGDFEEHALMGNHVGAPVAAPTPPRELPPPDIYREHRRAERPPSAPLLCGDGTAPRPLPASETRREGGIVASFPGCSRSSCPKAARTCRAAAQREQPNRRASANRAPRERGETHRGAGLRRCGARPPAARGDVPDLFPEAEAAHGCAPSCPEAAGRLAGPGRAPRSPLLRLPSYREACGHKPRGAACASYVCADSSGHPLYLGRSPREHHDGPGGGRGSGRWDGAYRDRGLRGEPGWVRAGGTERLAARGVTSPGAGGSWRRVNSLESEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y619</accession>
    <name>A0A8C2Y619_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Zinc finger protein 239-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC107321933</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015734906.1">
        <property type="nucleotide sequence ID" value="XM_015879420.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015734917.1">
        <property type="nucleotide sequence ID" value="XM_015879431.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y619"/>
    <dbReference type="Ensembl" id="ENSCJPT00005005636.1">
        <property type="protein sequence ID" value="ENSCJPP00005003121.1"/>
        <property type="gene ID" value="ENSCJPG00005003358.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107321933"/>
    <dbReference type="KEGG" id="cjo:107321933"/>
    <dbReference type="GeneTree" id="ENSGT01150000286944"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000295">
        <property type="entry name" value="zinc finger protein 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000269">
        <property type="entry name" value="Zinc finger protein 287"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000384">
        <property type="entry name" value="Zinc finger protein 550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000011">
        <property type="entry name" value="zinc finger protein 615 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000933">
        <property type="entry name" value="zinc finger protein 771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000099">
        <property type="entry name" value="Zinc finger protein 79"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24381">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24381:SF443">
        <property type="entry name" value="ZINC FINGER PROTEIN CKR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="129"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="157"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="185"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="213"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="241"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="269"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="297"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005003121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="321" mass="35768" checksum="5D0D6422D600862C" modified="2022-01-19" version="1">MDQGEDQDHEASKEICMGAEISPFLNHFASTDQQDLLSSIGGEEQLENSHGSQCGSTEAWRGDHREAEEAKLPCSAISLVKRQERRVAGAAQRAPGAERPTICSECGKGFSRSIHLIQHQRMHTGERPFLCGECGKGFSQSSNLIQHRRVHTGQKPYSCAECGKSFKNSSSLTIHQRIHTGERPYKCSECGKSFSDSSTCIKHQRMHTGERPYKCPACGKSFSQHSHLLQHQQVHNGVRPYSCGQCGKRFGQSSDLINHTRTHTGEKPYKCSQCGRGFSGNSNLIKHTRIHTGEQPYHCSQCGASFRFQPQLVRHQKHHTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y7J1</accession>
    <name>A0A8C2Y7J1_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">SIX homeobox 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">SIX1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIX/Sine oculis homeobox family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015721297.1">
        <property type="nucleotide sequence ID" value="XM_015865811.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y7J1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005009280.1">
        <property type="protein sequence ID" value="ENSCJPP00005005783.1"/>
        <property type="gene ID" value="ENSCJPG00005005470.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107315431"/>
    <dbReference type="KEGG" id="cjo:107315431"/>
    <dbReference type="CTD" id="6495"/>
    <dbReference type="GeneTree" id="ENSGT00940000156487"/>
    <dbReference type="OrthoDB" id="3501850at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035909">
        <property type="term" value="P:aorta morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001658">
        <property type="term" value="P:branching involved in ureteric bud morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090103">
        <property type="term" value="P:cochlea morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048701">
        <property type="term" value="P:embryonic cranial skeleton morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0086100">
        <property type="term" value="P:endothelin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030855">
        <property type="term" value="P:epithelial cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021610">
        <property type="term" value="P:facial nerve morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061197">
        <property type="term" value="P:fungiform papilla morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072198">
        <property type="term" value="P:mesenchymal cell proliferation involved in ureter development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072172">
        <property type="term" value="P:mesonephric tubule formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072075">
        <property type="term" value="P:metanephric mesenchyme development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042474">
        <property type="term" value="P:middle ear morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051451">
        <property type="term" value="P:myoblast migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051450">
        <property type="term" value="P:myoblast proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061055">
        <property type="term" value="P:myotome development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043524">
        <property type="term" value="P:negative regulation of neuron apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014033">
        <property type="term" value="P:neural crest cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048665">
        <property type="term" value="P:neuron fate specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030910">
        <property type="term" value="P:olfactory placode formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001759">
        <property type="term" value="P:organ induction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071599">
        <property type="term" value="P:otic vesicle development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003151">
        <property type="term" value="P:outflow tract morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007389">
        <property type="term" value="P:pattern specification process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060037">
        <property type="term" value="P:pharyngeal system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090190">
        <property type="term" value="P:positive regulation of branching involved in ureteric bud morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000729">
        <property type="term" value="P:positive regulation of mesenchymal cell proliferation involved in ureter development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000288">
        <property type="term" value="P:positive regulation of myoblast proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072513">
        <property type="term" value="P:positive regulation of secondary heart field cardioblast proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072107">
        <property type="term" value="P:positive regulation of ureteric bud formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034504">
        <property type="term" value="P:protein localization to nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072095">
        <property type="term" value="P:regulation of branch elongation involved in ureteric bud branching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050678">
        <property type="term" value="P:regulation of epithelial cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045664">
        <property type="term" value="P:regulation of neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:regulation of protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001014">
        <property type="term" value="P:regulation of skeletal muscle cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014842">
        <property type="term" value="P:regulation of skeletal muscle satellite cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008582">
        <property type="term" value="P:regulation of synaptic assembly at neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007605">
        <property type="term" value="P:sensory perception of sound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048741">
        <property type="term" value="P:skeletal muscle fiber development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048538">
        <property type="term" value="P:thymus development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030878">
        <property type="term" value="P:thyroid gland development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061551">
        <property type="term" value="P:trigeminal ganglion development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072193">
        <property type="term" value="P:ureter smooth muscle cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000063">
        <property type="entry name" value="SIX homeobox 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031701">
        <property type="entry name" value="SIX1_SD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10390">
        <property type="entry name" value="HOMEOBOX PROTEIN SIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10390:SF13">
        <property type="entry name" value="HOMEOBOX PROTEIN SIX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16878">
        <property type="entry name" value="SIX1_SD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 9 10" id="KW-0371">Homeobox</keyword>
    <keyword evidence="8 9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="12">
        <location>
            <begin position="122"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="9">
        <location>
            <begin position="124"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="168"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="179"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005005783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="282" mass="31785" checksum="A296E00480A42BAC" modified="2022-01-19" version="1">MSMLPSFGFTQEQVACVCEVLQQGGNLERLGRFLWSLPACDHLHKNESVLKAKAVVAFHRGNFRELYKILESHQFSPHNHPKLQQLWLKAHYVEAEKLRGRPLGAVGKYRVRRKFPLPRTIWDGEETSYCFKEKSRSVLREWYAHNPYPSPREKRELAEATGLTTTQVSNWFKNRRQRDRAAEAKERENTENNNAATNKPNQLSPLDGSKPLMSSSEEEFSPPQSPDQNSVLLLQGNLAHGRSSAYPLGSLPAPPGTHSLPGHQLQDSLLGPLTSSLVDLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YA81</accession>
    <name>A0A8C2YA81_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ornithine decarboxylase antizyme 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">OAZ1</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ODC antizyme family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2YA81"/>
    <dbReference type="Ensembl" id="ENSCJPT00005016744.1">
        <property type="protein sequence ID" value="ENSCJPP00005011473.1"/>
        <property type="gene ID" value="ENSCJPG00005009851.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159808"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008073">
        <property type="term" value="F:ornithine decarboxylase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902268">
        <property type="term" value="P:negative regulation of polyamine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090316">
        <property type="term" value="P:positive regulation of intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045732">
        <property type="term" value="P:positive regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0075523">
        <property type="term" value="P:viral translational frameshifting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.60:FF:000001">
        <property type="entry name" value="Ornithine decarboxylase antizyme 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002993">
        <property type="entry name" value="ODC_AZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038581">
        <property type="entry name" value="ODC_AZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10279">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE ANTIZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10279:SF8">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE ANTIZYME 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02100">
        <property type="entry name" value="ODC_AZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01337">
        <property type="entry name" value="ODC_AZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0688">Ribosomal frameshifting</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005011473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="213" mass="23926" checksum="C304F71A6F5ED277" modified="2022-01-19" version="1">MVKSSLQRILNSHCFAREKEGNKSIIMPAVLSLSTGQRFPSIAVVTWVRGLGGAPDVPHPPLKIPGGRGNSQRDHNLSANLFYSDNRLNVTEELTSNNRTRILNVQSRLTDAKHISWRAVLNNNNLYIEIPSGALPEGSKDSFAVLLEFAEEQLQVDHVFICFHKNRDDRAALLRTFSFLGFEIVRPGHPLVPKRPDACFMAYTFERDSAEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YB46</accession>
    <name>A0A8C2YB46_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Asparagine synthetase [glutamine-hydrolyzing]</fullName>
            <ecNumber evidence="2 11">6.3.5.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">ASNS</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-aspartate + L-glutamine + ATP + H2O = L-asparagine + L-glutamate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12228"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Amino-acid biosynthesis; L-asparagine biosynthesis; L-asparagine from L-aspartate (L-Gln route): step 1/1.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.4" evidence="2 11"/>
    <dbReference type="RefSeq" id="XP_015709139.1">
        <property type="nucleotide sequence ID" value="XM_015853653.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015709141.1">
        <property type="nucleotide sequence ID" value="XM_015853655.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015709142.1">
        <property type="nucleotide sequence ID" value="XM_015853656.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015709143.1">
        <property type="nucleotide sequence ID" value="XM_015853657.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YB46"/>
    <dbReference type="Ensembl" id="ENSCJPT00005019628.1">
        <property type="protein sequence ID" value="ENSCJPP00005013687.1"/>
        <property type="gene ID" value="ENSCJPG00005011523.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107309128"/>
    <dbReference type="KEGG" id="cjo:107309128"/>
    <dbReference type="CTD" id="440"/>
    <dbReference type="GeneTree" id="ENSGT00390000001994"/>
    <dbReference type="OrthoDB" id="409189at2759"/>
    <dbReference type="UniPathway" id="UPA00134">
        <property type="reaction ID" value="UER00195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042149">
        <property type="term" value="P:cellular response to glucose starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070981">
        <property type="term" value="P:L-asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045931">
        <property type="term" value="P:positive regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_synthase_B_C"/>
        <property type="match status" value="1"/>
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    <dbReference type="CDD" id="cd00712">
        <property type="entry name" value="AsnB"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="asparagine synthetase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Asparagine synthetase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050795">
        <property type="entry name" value="Asn_Synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033738">
        <property type="entry name" value="AsnB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01536">
        <property type="entry name" value="asn_synth_AEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11772">
        <property type="entry name" value="ASPARAGINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11772:SF23">
        <property type="entry name" value="ASPARAGINE SYNTHETASE [GLUTAMINE-HYDROLYZING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="2"/>
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    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="7 11 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 12" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="15">
        <location>
            <begin position="2"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="12">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="363"/>
            <end position="364"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for beta-aspartyl-AMP intermediate formation" evidence="14">
        <location>
            <position position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022888"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
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    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048741"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR001589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR001589-3"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005013687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="561" mass="64124" checksum="548A832C82F57421" modified="2022-01-19" version="1">MCGIWALFGSDECLSVQCLSAMKIAHRGPDAFRFENVNGFTNCCFGFHRLAVVDQLYGMQPIRVKKFPYLWLCYNGEIYNFKQLQKQFGFEYQTLVDGEVILHLYNRGGIEQTASMLDGVFAFILLDTANRKVFLARDTYGVRPLFKVLTDDGFLGVCSEAKGLINLKHSTSLFPKVEPFLPGHYEVLDLKPSGKVASVEVVKFHSYKDEPLHAACDTVENLPSGFDLETVKSNIRVLFENAVRKRLMAHRRIGCLLSGGLDSSLVAAVLLKLMKEMNIKYPLQTFAIGMENSPDLLAARKVAAHIGSEHHEVIFNSEEGIQAVEEVIFSLETYDITTVRASIGMYLVSKYIRKKTDSVVIFSGEGSDELTQGYIYFHKAPSPEEAAEESERLLKELYLFDVLRADRTTAAHGLELRVPFLDHRFTSYYLSLPAELRIPKNGIEKYLLRQSFEDSNLLPKEILWRPKEAFSDGIASVKKSWFSILQDYIDQQVDDLLLEKAAEKYPFNPPRTKESYYYRQIFEKHYPGRSNWLPHYWMPRWVKATDPSARTLKHYKSAAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YB76</accession>
    <name>A0A8C2YB76_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">FCH and double SH3 domains 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">FCHSD1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2YB76"/>
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        <property type="gene ID" value="ENSCJPG00005011422.1"/>
    </dbReference>
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        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032437">
        <property type="term" value="C:cuticular plate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031594">
        <property type="term" value="C:neuromuscular junction"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051170">
        <property type="term" value="P:import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061024">
        <property type="term" value="P:membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007274">
        <property type="term" value="P:neuromuscular synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030838">
        <property type="term" value="P:positive regulation of actin filament polymerization"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042542">
        <property type="term" value="P:response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901652">
        <property type="term" value="P:response to peptide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd07678">
        <property type="entry name" value="F-BAR_FCHSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11761">
        <property type="entry name" value="SH3_FCHSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000041">
        <property type="entry name" value="F-BAR and double SH3 domains protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000060">
        <property type="entry name" value="FCH and double SH3 domains protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035460">
        <property type="entry name" value="FCHSD_SH3_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735:SF4">
        <property type="entry name" value="F-BAR AND DOUBLE SH3 DOMAINS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735">
        <property type="entry name" value="FCH AND DOUBLE SH3 DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="F-BAR" evidence="10">
        <location>
            <begin position="53"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="9">
        <location>
            <begin position="495"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="161"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005013544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="602" mass="67133" checksum="12B1E935AE58EC38" modified="2022-01-19" version="1">MGVACNEWAGQSGRRSLERRGGVELQFRATHTRCGAGCGTGEMQPPPRKGKLSQVVKLHFAEQLCGLQSKQQRDAELLEDIRSYSKQRAAIEREYGQALQRLASQFVKREWQRGRSDAGDSRSVFAVWKGIIEGTAYTGQARVTASESYRSLAAEATKSSRLSKERMLKKSMEQLQKAQAELLETVKELDKAKKQFSHLQRSSEVAKDKAADVEARLRKSDRRIFHTKASLQKLSAKFSMQMAEYSKQRAGVQNEYVLMLVSANAHLEHYYHVELPAIMQALDGDLYERLRDHLSTAGRAEVESCEITRDWFQSISEAAARVCREQDLLLFLQDHTAFTLVPEQRFQLDGIQEVSLLQPEDGGASLEKEARRWAMRATRDSKNKAHGEEVLQKLEARRHQVPEAEAAVVERQMEEVRENIWKAEVGRAKAEARLALLRTAGLDVDSWLAGAVRAAGELPRTPSTEAPTGLDPTEFDDYDSDETFEEAEPGHAARTYPYTCRVIFGYQGCHADELSIAQGEELEVIEDGDMEEWVKARNKAGQVGYVPEKYLLSLSCVGSELDSAASTGATEPSGAALQRQLSSIMAAELVLEPGEPRGAELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YB98</accession>
    <name>A0A8C2YB98_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cysteine rich secretory protein LCCL domain containing 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">CRISPLD1</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_032298657.1">
        <property type="nucleotide sequence ID" value="XM_032442766.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032298658.1">
        <property type="nucleotide sequence ID" value="XM_032442767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YB98"/>
    <dbReference type="Ensembl" id="ENSCJPT00005020034.1">
        <property type="protein sequence ID" value="ENSCJPP00005014011.1"/>
        <property type="gene ID" value="ENSCJPG00005011757.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107310294"/>
    <dbReference type="CTD" id="83690"/>
    <dbReference type="GeneTree" id="ENSGT00940000156473"/>
    <dbReference type="OrthoDB" id="414826at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060325">
        <property type="term" value="P:face morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061484">
        <property type="term" value="P:hematopoietic stem cell homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd18813">
        <property type="entry name" value="CAP_CRISPLD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.33.10:FF:000001">
        <property type="entry name" value="Cysteine-rich secretory protein LCCL domain containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.130.20:FF:000001">
        <property type="entry name" value="Cysteine-rich secretory protein LCCL domain-containing 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.20">
        <property type="entry name" value="LCCL-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051957">
        <property type="entry name" value="CRISP-LCCL_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004043">
        <property type="entry name" value="LCCL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036609">
        <property type="entry name" value="LCCL_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31331:SF9">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN LCCL DOMAIN-CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31331">
        <property type="entry name" value="LCCL DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G08630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03815">
        <property type="entry name" value="LCCL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00603">
        <property type="entry name" value="LCCL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69848">
        <property type="entry name" value="LCCL domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01010">
        <property type="entry name" value="CRISP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50820">
        <property type="entry name" value="LCCL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="LCCL" evidence="7">
        <location>
            <begin position="302"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="LCCL" evidence="7">
        <location>
            <begin position="403"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="246"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005014011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="513" mass="57936" checksum="4BF69DAEDA51C1F5" modified="2022-01-19" version="1">MKYVVQEWLRITTLLFIAQAVSAMVLPNATLLEELLEKYMDEDGEWWIAKQRGKRAITDSDMQSILDLHNKLRGQVYPPASNMEYMTWDTELERSAESWAETCLWEHGPASLLPSIGQNLGAHWGRYRPPTFHVQAWYDEVRDFTYPHPHECNPYCPFKCSGPVCTHYTQVVWATSSRIGCAINLCHNMNIWGQIWPKAVYLVCNYSPKGNWWGHAPYKPGRPCSACPPSFGGGCRENLCYREDTERPYSPHEPEEETNEIERQQSKAQDATAQSRPRTHSPSSSTGTEDSEKNEVISTQQMSQIVSCEVRLRDQCKGTTCNRYECPAGCLDSKAKVIGSVHYEMQSSICKAAIHYGILDNEGGWVDVTRQGRKNYFIKSYRNGIQSIGKYQSANSFTVSKVTVQAVTCETTVEQLCPFQKPASHCPRVYCPPNCMQANPHYARVIGTRIYSDISSICRAAVHAGVVRNEGGYVDVMPVDKRKVYIASFQNGIFSESLQNPPGSKAFRVFAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YBS1</accession>
    <name>A0A8C2YBS1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YIPF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">YIPF1</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">cis-Golgi network membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the YIP1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015726195.1">
        <property type="nucleotide sequence ID" value="XM_015870709.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YBS1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005020916.1">
        <property type="protein sequence ID" value="ENSCJPP00005014732.1"/>
        <property type="gene ID" value="ENSCJPG00005012272.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107317721"/>
    <dbReference type="KEGG" id="cjo:107317721"/>
    <dbReference type="CTD" id="54432"/>
    <dbReference type="GeneTree" id="ENSGT00390000010157"/>
    <dbReference type="OrthoDB" id="10256463at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005797">
        <property type="term" value="C:Golgi medial cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000138">
        <property type="term" value="C:Golgi trans cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030133">
        <property type="term" value="C:transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039765">
        <property type="entry name" value="Yip5/YIPF1/YIPF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12822">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12822:SF4">
        <property type="entry name" value="PROTEIN YIPF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="8">
        <location>
            <begin position="100"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="23"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005014732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="305" mass="34601" checksum="9919E3E35CBF4718" modified="2022-01-19" version="1">MAAVDDLKFREFDDAAHLLAANPDATTISIDEPAEAHKNQHSRRQEPGREEDDELLGNESDKTELLAGQKKSAPFWTFEYYQTFFDVDTYQVLDRIKGSVFPVPGRNFVRLYVRSNPDLYGPFWICATLVFAIAVSGNLSNFFIHLGRPTYHYVPEFRKVSIAATTIYAYAWLVPLALWGFLMWRNSKVMNIVSYSFLEIVCVYGYSLFVYIPTAILWIIPHKVVRWVLMVFSLCLSGSVLVMTFWPAVRDDNRRIALATVGTIVLLHALLAVGCLAYFFDAPEVDFPAPVLPTHNGTTLITKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YBY7</accession>
    <name>A0A8C2YBY7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">DNA-binding protein SATB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Special AT-rich sequence-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">SATB1</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the CUT homeobox family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015709304.1">
        <property type="nucleotide sequence ID" value="XM_015853818.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015709305.1">
        <property type="nucleotide sequence ID" value="XM_015853819.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015709306.1">
        <property type="nucleotide sequence ID" value="XM_015853820.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015709307.1">
        <property type="nucleotide sequence ID" value="XM_015853821.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015709308.1">
        <property type="nucleotide sequence ID" value="XM_015853822.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YBY7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005021498.1">
        <property type="protein sequence ID" value="ENSCJPP00005015140.1"/>
        <property type="gene ID" value="ENSCJPG00005012578.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107309207"/>
    <dbReference type="KEGG" id="cjo:107309207"/>
    <dbReference type="CTD" id="6304"/>
    <dbReference type="GeneTree" id="ENSGT00390000008096"/>
    <dbReference type="OrthoDB" id="10052721at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016605">
        <property type="term" value="C:PML body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11585">
        <property type="entry name" value="SATB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000070">
        <property type="entry name" value="DNA-binding protein SATB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.40:FF:000003">
        <property type="entry name" value="DNA-binding protein SATB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.70:FF:000001">
        <property type="entry name" value="DNA-binding protein SATB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.710:FF:000001">
        <property type="entry name" value="DNA-binding protein SATB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.70">
        <property type="entry name" value="SATB, CULT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.710">
        <property type="entry name" value="SATB, ubiquitin-like oligomerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003350">
        <property type="entry name" value="CUT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032355">
        <property type="entry name" value="CUTL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039673">
        <property type="entry name" value="SATB1/SATB2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038216">
        <property type="entry name" value="SATB_CUTL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038224">
        <property type="entry name" value="SATB_ULD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032392">
        <property type="entry name" value="ULD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15116">
        <property type="entry name" value="DNA-BINDING PROTEIN SATB FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15116:SF14">
        <property type="entry name" value="DNA-BINDING PROTEIN SATB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02376">
        <property type="entry name" value="CUT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16557">
        <property type="entry name" value="CUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16534">
        <property type="entry name" value="ULD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01109">
        <property type="entry name" value="CUT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51982">
        <property type="entry name" value="CMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51042">
        <property type="entry name" value="CUT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51983">
        <property type="entry name" value="CUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0160">Chromosomal rearrangement</keyword>
    <keyword evidence="11 15 16" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12 15 16" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="14 15 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="13 17" id="KW-0804">Transcription</keyword>
    <keyword evidence="10 17" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="CMP" evidence="21">
        <location>
            <begin position="71"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="CUTL" evidence="22">
        <location>
            <begin position="175"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="CUT" evidence="20">
        <location>
            <begin position="361"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="CUT" evidence="20">
        <location>
            <begin position="484"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="19">
        <location>
            <begin position="665"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="15">
        <location>
            <begin position="667"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="266"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="614"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="266"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="625"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="786" mass="88243" checksum="B22625E154C32FFE" modified="2022-01-19" version="1">MDHLNEATQGKEHSEMSNNVSDPKGPPAKIARLEQNGSPLGRGRLGSTGTKMQGVPLKHSGHLMKTNIRKGSMLPVFCVVEHYENTIEYDSKEEHAEFVLVRKDMLFNQLIEMALLSLGYSHSSAAQAKGLIQVGKWNPVPLSYVTDAPDATVADMLQDVYHVVTLKIQLHSCPKLEDLPPEQWSHTTVRNALKDLLKDMNQSSLAKECPLSQSMISSIVNSTYYANVSAAKCQEFGRWYKHFKKAKDMMVEMDSLSELSQQGANHVNFGQQPVPGNTAEQPPSPVQLSHGSQPSVRTPLPNLHPGLVSTPISPQLVNQQLVMAQLLNQQYAVNRLLAQQSLNQQYLNHPPPVSRSMNKPLEQQVSTNTEVSSEIYQWVRDELKRAGISQAVFARVAFNRTQGLLSEILRKEEDPKTASQSLLVNLRAMQNFLQLPEAERDRIYQDERERSLNAASAMGPAPLISTPPSRPPQVKTATIATERNGKTENNSMNINASIYDEIQQEMKRAKVSQALFAKVAATKSQGWLCELLRWKEDPSPENRTLWENLSMIRRFLSLPQPERDAIYEQESNAVHHHGDRPSHIIHVPAEQIQSPSPTTLGKGEHRGAFLPSLLTTGPWLGAAPQQQQQQQQQQQQQQQQQQPGPRLPPRQPTVASPAESEDENRQKPRPRTKISVEALGILQSFIQDVGLYPDEEAIQTLSAQLDLPKYTIIKFFQNQRYYLKHHGKLKDNSGLEVDVAEYKEEELLKDLEDSIQDKNANTLFSVKLEEELSVEGNTEINAELKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YD30</accession>
    <name>A0A8C2YD30_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">b(0,+)-type amino acid transporter 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Glycoprotein-associated amino acid transporter b0,+AT1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Solute carrier family 7 member 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">SLC7A9</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-phenylalanine(out) + L-arginine(in) = L-phenylalanine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71067"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:71068"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-cysteine(out) + L-arginine(in) = L-cysteine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71071"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:71072"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-cystine(out) + L-arginine(in) = L-cystine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71075"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:35491"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:71076"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-histidine(out) + L-arginine(in) = L-histidine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71063"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:71064"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-leucine(out) + L-arginine(in) = L-leucine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71059"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:71060"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-lysine(out) + L-arginine(in) = L-lysine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:70827"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:70828"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015729428.1">
        <property type="nucleotide sequence ID" value="XM_015873942.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YD30"/>
    <dbReference type="Ensembl" id="ENSCJPT00005024705.1">
        <property type="protein sequence ID" value="ENSCJPP00005017733.1"/>
        <property type="gene ID" value="ENSCJPG00005014443.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107319252"/>
    <dbReference type="KEGG" id="cjo:107319252"/>
    <dbReference type="CTD" id="11136"/>
    <dbReference type="GeneTree" id="ENSGT00940000156370"/>
    <dbReference type="OrthoDB" id="5982228at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031526">
        <property type="term" value="C:brush border membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180009">
        <property type="term" value="F:broad specificity neutral L-amino acid:basic L-amino acid antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015184">
        <property type="term" value="F:L-cystine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000015">
        <property type="entry name" value="B(0,+)-type amino acid transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF354">
        <property type="entry name" value="B(0,+)-TYPE AMINO ACID TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="113"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="309"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="413"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="442"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00074336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00079910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00083296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00093193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005017733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="493" mass="53851" checksum="12ED4F62E67290CC" modified="2022-01-19" version="1">MGEGSLRKRKDQDNRKEDGQSIQSQEPQATNLKKQVGLISGICMIVGTIIGSGIFVSPKSVLANVGAVGPCLTIWAVCGVLATLGALCFAELGTMIAKSGGEYPYLMEAFGPIPAFLFSWASLLVIKPSSFAIICLSFAEYASAPFYPGCDPPPVVIKCLAAAAIVVITIVNSLSVKLGSYLQNFLTAAKMIVVAIIAVTGIVLLAQGKTQNFQDSFKDSKISVSSIGLAFYNGLWAYDGWNQLNYITEELKNPYRNLPLSIIIGIPLVTVCYVLINVSYFTVMTSTELLQSQAVAVTFGDRVLYPASWIIPLFVAFSTIGSANGVCFTAGRLVYVAGREGHMLEVLSYISVKRLTPAPAIIFYGAVTIIYIIPGDINTLINYFSFAVWIFYGLSVFALIVMRFTRKELKRPIRIPIIIPVIVTLISILLVLAPIITAPELAYLYCVLFILSGLIFYVLFVHFKFKWSQKISEPITMYLQMLLEVVPPEEVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YDJ2</accession>
    <name>A0A8C2YDJ2_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hyaluronan synthase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">HAS3</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015729811.1">
        <property type="nucleotide sequence ID" value="XM_015874325.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YDJ2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005025750.1">
        <property type="protein sequence ID" value="ENSCJPP00005018514.1"/>
        <property type="gene ID" value="ENSCJPG00005015075.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107319480"/>
    <dbReference type="KEGG" id="cjo:107319480"/>
    <dbReference type="CTD" id="3038"/>
    <dbReference type="GeneTree" id="ENSGT00390000010337"/>
    <dbReference type="OrthoDB" id="9876900at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036117">
        <property type="term" value="C:hyaluranon cable"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050501">
        <property type="term" value="F:hyaluronan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085029">
        <property type="term" value="P:extracellular matrix assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030213">
        <property type="term" value="P:hyaluronan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900106">
        <property type="term" value="P:positive regulation of hyaluranon cable assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd06434">
        <property type="entry name" value="GT2_HAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22913">
        <property type="entry name" value="HYALURONAN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22913:SF6">
        <property type="entry name" value="HYALURONAN SYNTHASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13641">
        <property type="entry name" value="Glyco_tranf_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="373"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="404"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="439"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="469"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="505"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005018514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="548" mass="62083" checksum="0E46AA38293C2B5C" modified="2022-01-19" version="1">MPVSLSTALRVVGTSLFALAVLGGILAAYVTGYQFIHTEKHYLSFGLYGAILGLHLFIQSLFAFLEHRRMRAEGQPVRLGRSVALCIAAYQEDPDYLKKCLHSVKRIAFPDLKVVMVVDGNGPDDTYMLDIFHDVMGSERAGSYVWRSNFHARGEGETEAGLQEGLARVQALVRGTTYSCILQKWGGKREVMYTAFRALGDSVDYIQVCDSDTVLDPACTAEMLRILEADPRVGGVGGDVQILNKYDSWISFLSSVRYWMAFNIERACQSYFGCVQCISGPLGMYRNALLQQFLEDWYHQTFLGSQCSFGDDRHLTNRVLSLGYQTKYTARSRCLTETPTRYLRWLNQQTRWSKSYFREWLYNALWFHKHHLWMTYEAVITGFFPFFLIATVIQLFYRGRIWNILLFLLTVQLVGIIKATYACFLRGSAEMIFVSLYSLLYMSSLLPAKMFAIATINKSGWGTSGRRTIVVNFVGLLPVSVWAAVLLGGLAYTAYSQDLLSDTEVAFLISGAVLYACYWVALLTLYLAMVARRCGKRQEQCRLVFAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YE79</accession>
    <name>A0A8C2YE79_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Coiled-coil domain containing 174</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">CCDC174</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YE79"/>
    <dbReference type="Ensembl" id="ENSCJPT00005027602.1">
        <property type="protein sequence ID" value="ENSCJPP00005019979.1"/>
        <property type="gene ID" value="ENSCJPG00005016139.1"/>
    </dbReference>
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        <property type="component" value="Chromosome 12"/>
    </dbReference>
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        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025066">
        <property type="entry name" value="CCDC174-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057464">
        <property type="entry name" value="CCDC174_GRSR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15885">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15885:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25449">
        <property type="entry name" value="CCDC174_GRSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13300">
        <property type="entry name" value="DUF4078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCDC174 alpha/beta GRSR" evidence="3">
        <location>
            <begin position="163"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="42"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="125"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="306"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="125"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="141"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="376"/>
            <end position="388"/>
        </location>
    </feature>
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        <location>
            <begin position="404"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="420"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="467"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005019979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="532" mass="61104" checksum="A9482066833D5DAE" modified="2022-01-19" version="1">MDRRKKPLDVAASSLVDLKAELFRKQEEFKKEKLLKDAGIFAKPKPTNKKPSIWTKQNTGVAKRAEKDIEQKAEEDQTLDQSRKKLEEKAKLYEKMTKGDFPDEETEDLYLVDFTQKIIDKQREVQELHQNETDRKTLEKETDDEEIEPEMEIPPPEDPDEEWVDYVDSLGRSRRCMKKDLPGILKMDQELQGKRLDPDGNTLLSEDMKRELQRQQWEKEEEEALRKPMGPIHYEDIRENEARQLGVGYFAFSRDQDLRHKQRATLDMLREQTLDQRTKREQLKEKRKAALESRLSKLRARKVKKLREEGLEEEAERLENGEVKEATSPVEAEPEVPRPSRKVEVVIQERRDTKPGVPYVREWDKGKELMFGQWSKKQEELRDERDPEFAPPSDYFMGQKKGDSYSSQNLSSPETSPGRTEPEISEDQKKSAQASTHRAEVVPPSVQAYSNSGQGAEASGSVAEDGSTSEETDSSDEQDGLPSAHPYICGHCACTSHPSAAGEEHSALIPSGSYESVCWFILDSCNKPEHPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YEE4</accession>
    <name>A0A8C2YEE4_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Connector enhancer of kinase suppressor of ras 2-like</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YEE4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005028234.1">
        <property type="protein sequence ID" value="ENSCJPP00005020459.1"/>
        <property type="gene ID" value="ENSCJPG00005016477.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000164237"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01260">
        <property type="entry name" value="PH_CNK_mammalian-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Connector enhancer of kinase suppressor of Ras 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CNK2/3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051566">
        <property type="entry name" value="CNKSR"/>
    </dbReference>
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        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12844">
        <property type="entry name" value="CONNECTOR ENCHANCER OF KINASE SUPPRESSOR OF RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12844:SF12">
        <property type="entry name" value="CONNECTOR ENHANCER OF KINASE SUPPRESSOR OF RAS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06663">
        <property type="entry name" value="CNK2_3_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="170"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
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        </location>
    </feature>
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            <begin position="380"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005020459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="623" mass="71362" checksum="A0F10CDDBF74FA41" modified="2022-01-19" version="1">MPTDYSWIGESKEQNIYKRGSRDSENSLLRYLSDDKILVIQEEPLTQKDSKRDTGRRSRKKGKSASSPNYPISPSVLTSTINVRLEPGQQDILNFALAENNTVPLYHRAGDTVSGDTERYASSAIDRQGSTSMRKSFHYASLRVKSRKWSKGSSLTSGSRRRISCKDLGHGDCEGWLWKKKDAKGYFTQKWKKYWFILKDSSLYWYTNQNDEKAEGFISLPEFRIDRAIECRKKHAFKACHPKIKSFYFATDCLEEMNRWMNRLGLAAIGYTPDDKDIHPDEDYWSESDQDDVDGSLTLKQEGSSTLCDTYHRTPSVTSSSPFPEAKHGRHFSSESTYSHSSAEDSRQDVAGSTHSSGCRPPYRERRSWQDLIETPLTSSGLHFLQTVPPDPEYVSGQPGMSPERRRQATLPVQRRHNYEQDGPFPLVECQRGHSSHNRPQKQRSQSLPRNRDVRVKGRVKSIEGTEEILEEKIPIRRHNSFCAEESIKETEENLDGLQELYKSLEQASLSAFGEQRPSTKQEFRKSFVKRCNDPVINEKLHHIRALKSTLKAKEGDLTVINSLLDDPNLTSKKFKDWKLKNYEFFLDICEYSAALKSQNGASELATSAPMLTHTHSFIETHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YEM3</accession>
    <name>A0A8C2YEM3_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LisH domain and HEAT repeat-containing protein KIAA1468</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">RELCH</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Recycling endosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2YEM3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005028717.1">
        <property type="protein sequence ID" value="ENSCJPP00005020857.1"/>
        <property type="gene ID" value="ENSCJPG00005016435.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000004385"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032367">
        <property type="term" value="P:intracellular cholesterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000080">
        <property type="entry name" value="lisH domain and HEAT repeat-containing protein KIAA1468 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000218">
        <property type="entry name" value="lisH domain and HEAT repeat-containing protein KIAA1468 homolog isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040362">
        <property type="entry name" value="RELCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32059">
        <property type="entry name" value="RAB11-BINDING PROTEIN RELCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32059:SF0">
        <property type="entry name" value="RAB11-BINDING PROTEIN RELCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="HEAT" evidence="10">
        <location>
            <begin position="1002"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="125"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="410"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="182"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="344"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="410"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00084053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005020857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1214" mass="134620" checksum="6A2A9FEF18F6B7D4" modified="2022-01-19" version="1">MAAAGGGSSVNPFLSDSEEDEPEEARPGGGGSSSSTEPGGPAYPARRREEAAAVGSPEELPGLRAAGDTAGPGGGAAAGEPPRVSMDAMAAQLLRDQFLLTALELHTELLESGRELPRLRDFFSNPGNFERQSGTPPAGGGLGGSVLGGAGGREPGSGQLNRAGSISTLDSLDFARYSDDGNRETDERVAVLEFELRKAKETIQALRANLTQAAENEVPLQERKNYKSSPEIQEPIRPLEKRALNFLVNEFLLKNSYKLTSITFSDENHDQDFELWDDVGLNIPKPPDLLQLYRDFGNHHVTARDVVDVSVGVDDDELEAATPILGTVPVFETAPQSIEQCLIVQKLEDQISVLNNEKWSLMEQIQRLESEIDFLKNENFATSTVYGVEPHPSLKQVPHAVSEDNGRYLDIKSSENDSKHGNTEEKSLSSSAEHDTRTSKDDTLNSMPCKDTEKVSSCAPSTKSAVHFDKPNRKLSPAFHQALLSFCRMSADSRLGSEVSRIADSEKSVMLMLGRCLPHIVPNVLLAKRERMVLHLCQELIPLILCTACLHPEPKERDQLLHILFNLIKRPDDEQRQMILTGCVAFARHVGPTRVEAELLPQCWEQINHKYPERRLLVAESCGALAPYLPKEIRSSLVLSMLQQMLMEDKADLVREAVIKSLGIIMGYIDDPDKYQQGFELLLSALGDPSERVVSATHQVFLPAYAAWTTELGNLQFHLIPTLLSKIEKLLREGEHGLDEHKLHMYLSALQSLIPSLFALVLQNAPFTSKAKLQGEVPQIEVTRFPRPASPLQDVAIIIGSREQLAVLLQLYNHQLEHEGTTGWETLLWVVNQLLPQLIEIVGKINVASTACVHEFSRFFWRLCRTFGKIFTNTKVKPQFQEILRLSEENIDSTAGNGVLTKATVPIYATGVLTCYIQEEDRKLLVGFLEDVMTMLSLSHAPLDSLKASFVELGANPAYHELLLTVLWYGVVHTSALVRCTAARMFELLVKGVHETLVAQRVVPALITLSSDPEISVRIATIPAFGTIMETVTQRELLERVKMQLASFLEDPQYQDQHSLHTEIIKTFGRVGPNAEPRFRDEFVIPHLHKLALVNNQQSVDSKRLDIATHLFEAYSALSCCFISEDLMVNHFLPGLKCLRIDMEHLSPEHEVILSSMIKECEQKVENKTVQEPQGSMSIAASLVSEDTKTKFLNKMGQLTTSGAMLANVFQRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YHB7</accession>
    <name>A0A8C2YHB7_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nebulin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">NEB</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="Ensembl" id="ENSCJPT00005036002.1">
        <property type="protein sequence ID" value="ENSCJPP00005026561.1"/>
        <property type="gene ID" value="ENSCJPG00005020515.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154533"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071691">
        <property type="term" value="P:cardiac muscle thin filament assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11789">
        <property type="entry name" value="SH3_Nebulin_family_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000007">
        <property type="entry name" value="nebulin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055297">
        <property type="entry name" value="NEBU/NEBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013998">
        <property type="entry name" value="Nebulin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000900">
        <property type="entry name" value="Nebulin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11039">
        <property type="entry name" value="NEBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11039:SF37">
        <property type="entry name" value="NEBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00880">
        <property type="entry name" value="Nebulin"/>
        <property type="match status" value="38"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00510">
        <property type="entry name" value="NEBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00227">
        <property type="entry name" value="NEBU"/>
        <property type="match status" value="75"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51216">
        <property type="entry name" value="NEBULIN"/>
        <property type="match status" value="53"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="2778"/>
            <end position="2837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2694"/>
            <end position="2726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005026561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="2837" mass="326870" checksum="E6375BB8C31F0DB0" modified="2022-01-19" version="1">MPDTPTILLAKANAANVSHKHYVQAWEDAKKKGYDMRADAIPIRSAKASRDIASDYKYKEAHEKQKGHYIGCRTAKEDQAVVGCPSHVCCRTTAFTRRRTTTPRPRSTLPGMEPIVMQAAKECQTLVSDADYRHYLHQWTCLPDQNDVVHARKAYDLQSDAVYKSDLEWLRGIGWLPNDSPGIQRVKHAQDLLSDKVYRTPIDSVKYTSVVDSPAIVLAKTNAEQLSIPKYKEAWEKDKTMIHIMPDTPEITLAKSNAHNYSKKLYKEAWDEVKMSYDLRADAIPIKAAKASREIASDYKYKLDHEKQKGHYVGVPNAKADAKIQFALGIGKVQSELEYKKHFAKWKTQCHLPVDMMSIQSAKHGQSLVSDIDYRHYLHQWICLPDQNDVMHARKAYDLQSDAVYKSDLEWLRGIGWLPNDSLGINHVKYAGDLLNERKYRTKADTLRFTPVADRVDYVTAKKSGEILSDIIYHKEWNEVKSNYSLTDTPQLDMAREAARILNQNLYKESWEKEKATGYLLPPDTVQIRHAKHSNDVQSELKYKADYVKQRGHYVGVASMRDDPKLVWFEHAGEIQNDRLYKSDYHKTKSKIHIPVDIMSVVAAKECQTLVSDVDYRQYLHQWTCHPDQNDCIQARKAYDLQSDNIYKSDLEWLRGCGWVPLDSVEHKKVKHAQELINKRAYTKAAVENFSNYTSVVDTPDIVLAKMNSVNQSDLKYKETFNLEKGQYIGSDDTPELNHARDMSLLYSDKLYKNDWEISKPTGYTLDGKYIPLVGAKHANYVNSERKYKELYEKLKGHYLAGKDIGDFPSVVHSLAFQKIRSALAYRKNYEDTKTKVHIPSDMMNHVLAKKCQYILSDLEYRSYLHHWNCSPEEHDVIQARRAQEILSDVVYKDDLNWLKGIGCYVWDTPQILHAKNAYDLQSQIKYTASGKENFPNFGVVTVTPTYVAAVQSGIHASDIKYKEDYHKTKDKYTTVTETVDSERVQNLKHLFSNNLYKEAWDKVKATSYIMPSDAVSLARAKELKHNASYVKYREEYDKFKALYTLPRSVEDDPNTARCLRVGKLNIDRLYKETYEKTKTKVHILPDMVDIIAAKDAQKKISEIDYRTRLHDWICLPDLQINMHVRKVADQISDVVYKDDLNWLKGIGCFVWDTPEILHAKHAYDLRSDIKYKSNAEKMKNKYTVVMDTPVYVQNILSALNASEVIYRGDYLNKVRGKAIPTDKTVDLERARHANKIQSENLYRWAGLKALPTGYSLPKDTPGFQHAKHVQHIGSDLKYKEAYEHMKAKGYTLGPHDVGFENAKKVNQVINERLYRATYHKNKDKIHTTPDTPEIRQVKATQEAVSDLIYKSDFFKMQGHLISMPFTPQVLHCRYVGDITSDNKYKEDLKWLQGLGCFLYDTPDMVRARQLRKLWSNYIYTGTAKKMRDKYSVVLDTPEYRTIQELKSHLSELVYRSAGKELKTKYTSVLNTPDFLRAKEGQKIQSQYLYVALATKERPHHHAGSQTPAFTHARHVKDMVSETKYKMQYEKMKDKYTPVHDTPVLIRAKRAYLNASDLRYKETFENTKGKYHTVKDALDIVYHRKVTDDISSVKYKENYMSQLGVWRSIPDRPEHFHHRLVTDAISDVKYKEDLSWLRGIGCYAWDTPDFTLAGKNKVLYSENKYKEAFEKTKSHFKYVADSPINRHFKHATQLLDAVSVEYKKDYEKKKDKYTTVVDTPENLRTAKVNKQISDIIYKLEYNKSKPKGYTTIHDTPMLLHVRKVKDRISDLKYKEVYERNKSHCNVVADSVHIKTPRNTYKLNSNLDYKKKYEAAKAHWHWIADRPDFVQAAKSSLQQSDYEYKLDREFLKGCKLSVTDDKNTVLALNNAILASDIKYKEKHNKARGTCLVVPDTPQILLAKNVSNLVSENKYKEHSKKQLPRGSYTTLPETRDTAHVKEVTKNVSDTNYKKKFVKEKGKSNYSIMLEPPEVKHAMEVAKKQSTVEYKKDAKSKLHYTPIADRPDIKKATQAAKLISDIEYKKRGEAGLGVTMLGRPDIELAKEVSKLTSQVKYKENFSKEKGKKPKYDLKEAKIYKTMKDAHNMASEVKYKADLKKLHKPVTDMSESLIMNHVLNTSQLASAYQYKKQYEKSKGHYHMVPDNLEQVHLREASELQSHVKYKEKYEKEKGKPMLDFETPTYLTAKESQLMQSEKQYKRDFEESIKGRNLTGLEITPSLLHVKYATKIASEKEYRKDLEEGVKGKGLSVLEETPDMLRAKNATQILNEKEYKKALELEIKGKGLSELALETPDFVRAKNATDIASQIKYKQLAEMEKANYTSVVDTPEIIHAQQVKNLSSQKKYKEEAERTMPYYVPVTDTPEMQRVRENQKNFSTLQYQWDLQNSKGKVTVVQDTPEMLRVKENQKNFSSILYKEDIGTGTTIEKTPEMQRVKRTQDAISSIKYKESIGKGTPIPDLPEVKRVKETQKHISSVSYKEGLGTGIPTPVTPEMERVKRNQENISSVLYKESVGTGTPTPVTPEMERVKRNQEICSSVLYKENIGKATPTPVTPEMERVKRNQEIISSVLYSDSFRKQVQGKAAYVLDTPEMRRVRETQKHISTVKYHEDFEKNKGTFTPVVTDPITERVKKNMQDFSDISYRGIQRRVVEMEQKRVDQDQENLTGLRVWRTNPGSVFDYDPAEDNIQSRSLHMISVQAQRRSREHSRSASALSISGGDEKSEPSEGVNQHLSYYSNGGFFTTTTTVGYKHAKTIELPQQRSASVATQQTTVSSVPSHPSTAGKTYRAMYDYTAADADEVSFKDGDYIINVQPIDDGWMYGTVQRTGKTGMLPANYVEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SLS1</accession>
    <name>A0A8C2SLS1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">PTPN21</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="3"/>
    <dbReference type="RefSeq" id="XP_015720831.1">
        <property type="nucleotide sequence ID" value="XM_015865345.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015720833.1">
        <property type="nucleotide sequence ID" value="XM_015865347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SLS1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005000339.1">
        <property type="protein sequence ID" value="ENSCJPP00005000161.1"/>
        <property type="gene ID" value="ENSCJPG00005000243.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107315226"/>
    <dbReference type="KEGG" id="cjo:107315226"/>
    <dbReference type="CTD" id="11099"/>
    <dbReference type="GeneTree" id="ENSGT00940000155613"/>
    <dbReference type="OrthoDB" id="10012364at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13188">
        <property type="entry name" value="FERM_C_PTPN14_PTPN21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17192">
        <property type="entry name" value="FERM_F1_PTPN21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000014">
        <property type="entry name" value="Tyrosine-protein phosphatase non-receptor type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000149">
        <property type="entry name" value="Tyrosine-protein phosphatase non-receptor type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000039">
        <property type="entry name" value="Tyrosine-protein phosphatase non-receptor type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000030">
        <property type="entry name" value="Tyrosine-protein phosphatase non-receptor type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018979">
        <property type="entry name" value="FERM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018980">
        <property type="entry name" value="FERM_PH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014392">
        <property type="entry name" value="PTP_non-rcpt_14/21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041782">
        <property type="entry name" value="PTPN14/21_FERM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45706">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45706:SF3">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09380">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09379">
        <property type="entry name" value="FERM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000934">
        <property type="entry name" value="Tyr-Ptase_nr14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00935">
        <property type="entry name" value="BAND41"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01196">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FERM" evidence="13">
        <location>
            <begin position="23"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="11">
        <location>
            <begin position="943"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="12">
        <location>
            <begin position="1125"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="339"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="745"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="835"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="758"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="839"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="9">
        <location>
            <position position="1155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000934-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005000161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1221" mass="139384" checksum="FCFBCD49B165ECCE" modified="2022-01-19" version="1">MPLPFGLKLKRTRRYTVSSKSCLVARIQLLNNEFVEFTLSVESTGQESLEAVAQRLELREITYFSLWYYNKQNQRRWVDLDKPLKKQLDKYALEPTVYFGVVFYVPTVSQLQQEITRYQYYLQLKKDILEGSIPCTLEQAIHLAGLAVQADFGDYDQYESQEFLQRFALFPVGWLQEEKILEEATQKVALLHQKYRGLTPPDAEMLYMQEVERMEGYGEETYPAKDSQGSDIFIGACLDGIFVKHKNSRPPVVFRWHDIANMSHNKSFFALELANKEETIQFQTEDMETAKYVWRMCVARHKFYRLNKCSLDSLDSPPEEGSQKSSLILSLPRFPILSRPSLPKGQTQPITVNPVRRRSSSRMSMPKPQAYMMPPPPQLHYNGHYTEPYASSQDNLFVSSQNGYYYHSQTSLDRAPHDYSGRIRNGSVYSAHSTNSLNNPQHYLQPSPMSSNPSITGSDVLRTDYVPSHRHSALIPPSYRPTPDYETVMRQLNRGMVHTDRQSHSMRNLNISNTYAYSRPDALVYSQPEIREHAHFTSPQSNHYPFNLNYSFHSPSPYPYPAEKRPVVGAVSVPELTNVQLQAQDYPAPNIMKTQVYRPPPPYPYPRPANSTPDLSRHIYISSSNPDLITRRVHHSVQTFQEDSLPVAHSLQEVSEPLTSARHAQLQKRNSIEIAGLAPSFEGIRIKERTMSASAADVALPRVISEGSQPNILIERTKQKENEQDEGVNCDHKKTLSDATMLIHSSEEEEEDFEENKASTSLSPLPEDQTQLSSMMGGYSHDSVLNYPYSSVASSAGPLHILEPKLHITETEKRMKDISPVHLLVENHIQRRGEGLLTPSMSESDLTTSGRYRLRKDSSSIKKRPVSDLLSGKKNIVEGLPPLGGMKKNKTDAKKIGPLKLAALNGLTLARMPLPDEGKEESTRATNDERCKVLEQRLEQGMVFTEYERIQKKRLIDGECSIARLPENAERNRFQDVLPYDDTRVELVPTKENNTGYINASHIKISVGGIEWDYIATQGPLQNTCQDFWQMIWEQGIAIIAMVTAEEESGREKSFRYWPRLGSRHNTVTYGRFKITTRFRTDSGCYATTGLKIKHLLTGQERTVWHLQYTDWPEHGCPEDLKGFLSYLEEIQSVRRHTNSTADPKNSNPPVLVHCSAGVGRTGVVILSEIMIACLEHNEMLDIPRVLDMLRHQRMMMVQTLSQYTFVYGVLIQFLKSSRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SNG1</accession>
    <name>A0A8C2SNG1_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Angiomotin like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">AMOTL2</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Podosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Recycling endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the angiomotin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SNG1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005001469.1">
        <property type="protein sequence ID" value="ENSCJPP00005000833.1"/>
        <property type="gene ID" value="ENSCJPG00005000903.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156577"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002102">
        <property type="term" value="C:podosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001525">
        <property type="term" value="P:angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003365">
        <property type="term" value="P:establishment of cell polarity involved in ameboidal cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035329">
        <property type="term" value="P:hippo signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903829">
        <property type="term" value="P:positive regulation of protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030334">
        <property type="term" value="P:regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009114">
        <property type="entry name" value="Angiomotin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051747">
        <property type="entry name" value="Angiomotin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024646">
        <property type="entry name" value="Angiomotin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14826">
        <property type="entry name" value="ANGIOMOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14826:SF3">
        <property type="entry name" value="ANGIOMOTIN-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12240">
        <property type="entry name" value="Angiomotin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01807">
        <property type="entry name" value="ANGIOMOTIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0965">Cell junction</keyword>
    <keyword evidence="11" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="domain" description="Angiomotin C-terminal" evidence="14">
        <location>
            <begin position="437"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="38"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="597"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="648"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="269"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="495"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="72"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="94"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="125"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF12240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005000833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="726" mass="80084" checksum="83F42AEC01BFBAE3" modified="2022-01-19" version="1">MRTAEDSSGTVLQRLIQEQLRYGNLTENRTLLAIQQQALRGGTAGSPRSSLESLTQEESQMVPQSARQEPQGQEHHADHLYNEHGGYRPAQPQHKGEELPSYEEAKAHSQYYAGQRAGQQHGGTRRPDDALKELKHGHVRSLSERLMQMSLERNGAKAHGPISSSHSFPQLSRQYTLRGQRPEGTEPRGPPPEYPYILPSQEAAVAYLSRPCSRDGAGFQHPEVSRLMPAPVPAAFLPSPSTLGSLSPAGVEALVSAQAASAGSRLAQVDAVMRENERLLLDNERLRRELESCTEKASRIQKLETEIQRISEDYENLMKASSKREALEKAMRAKRDGEMRRLQDFNRDLKERLESANKQLASKTQENQESNQGTVAKLLAQSYEHQQEKEKLEREASLLRSANEDQRRRAELLEQALGSAQARAAKAEAELRKKRAYVEKVERLQAALGQLQAACEKREQLELRLRTRLEQELKMLRAQQRQVGTTGGGTPELSAHRLSEQLREKEEKILALEADMTKWEQKYLEECTMRQFAMDAAATAAAQRDTTLISHSPRHSPNSSFNEDLLLANHKHQEMESRLKALHAQILEKDAVIKVLQQRSRRDPSKALQGSLRPAKSVPSVFAASAAEGSSRGSTAGKTAADEAALVPTAVPLPSHTKHGSKDGSTQTDGMAQSRGEGAECPASSPGESCGPQGCTKGCGGAQRTGLESSTIPRAPDLSDMVEILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SNN3</accession>
    <name>A0A8C2SNN3_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATPase H+ transporting accessory protein 1 like (pseudo</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ATP6AP1L</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the vacuolar ATPase subunit S1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015705241.1">
        <property type="nucleotide sequence ID" value="XM_015849755.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SNN3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005000804.1">
        <property type="protein sequence ID" value="ENSCJPP00005000431.1"/>
        <property type="gene ID" value="ENSCJPG00005000521.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107306517"/>
    <dbReference type="CTD" id="92270"/>
    <dbReference type="GeneTree" id="ENSGT00940000158156"/>
    <dbReference type="OrthoDB" id="9442153at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome Z"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098588">
        <property type="term" value="C:bounding membrane of organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033176">
        <property type="term" value="C:proton-transporting V-type ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030641">
        <property type="term" value="P:regulation of cellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.110:FF:000003">
        <property type="entry name" value="ATPase H+ transporting accessory protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008388">
        <property type="entry name" value="Ac45_acc_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046756">
        <property type="entry name" value="VAS1/VOA1_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046755">
        <property type="entry name" value="VAS1_LD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12471:SF3">
        <property type="entry name" value="ATPASE, H+ TRANSPORTING, LYSOSOMAL ACCESSORY PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12471">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20520">
        <property type="entry name" value="Ac45-VOA1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05827">
        <property type="entry name" value="VAS1_LD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034329966" evidence="7">
        <location>
            <begin position="21"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="V-type proton ATPase subunit S1 luminal" evidence="8">
        <location>
            <begin position="181"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="V-type proton ATPase subunit S1/VOA1 transmembrane" evidence="9">
        <location>
            <begin position="343"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005000431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="424" mass="48172" checksum="60819DF721872D04" modified="2022-01-19" version="1">MLVLLHVVWTRAVPTPGACSQRTWKHTETWCRWVPEHRRLSLAASAVHHTVGRAGLRSTPPPTSPEEQMCSEWSHQLFSMERNAALRLFLLFSCLGFSASVERMLATVAGSSHVVSDQDSLQRTGRRYDGGVKPKFNVNQVAVAQVVSYNLSRKEHLERASWRPFTHNHNSPLNVTINGIPCILFWAKRIMIKFENHTQLDLTEKTFGVHATVDVGDSNCSEDNAMLSLKFGDIGNLKGLVIRFLLTTSYYQLSVQNWFSLQRLQLLYNHSVQATFNATRIYAPASYSFHCEHVSSLQRYDALLIPSSANDVSKLWEVTFIDFQIQGFNIQEGHFAYAKDCASFFSPAILMGLVMSLILLLVLAYALHMLIHLKSLDRHYECKASPAYFAQMKDSDMGDEKEPLRISGNESYELRSQQFCKIYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SNX1</accession>
    <name>A0A8C2SNX1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Small integral membrane protein 15</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMIM15 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SNX1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005002614.1">
        <property type="protein sequence ID" value="ENSCJPP00005001579.1"/>
        <property type="gene ID" value="ENSCJPG00005001594.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000165045"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome Z"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027877">
        <property type="entry name" value="Smim15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28644">
        <property type="entry name" value="SMALL INTEGRAL MEMBRANE PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28644:SF1">
        <property type="entry name" value="SMALL INTEGRAL MEMBRANE PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15086">
        <property type="entry name" value="UPF0542"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005001579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="171" mass="18824" checksum="B4730D2E944C37BB" modified="2022-01-19" version="1">MPASPLRRAARRPMQQCPMRRSAYAVTTCAEQAGPPAAPLRAAAPCIRIAGRAVVPLPAAGFLFSPQGPSCRSSDACRAHGAALPLVQCFPHKKAAEMFDVKAWAVYIVEWAAKDPYGFLTTVILVLTPLFIISAALSWKLAKMIETREREQKKKRKRQENIVKAKRAKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SPS4</accession>
    <name>A0A8C2SPS4_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SPS4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005000465.1">
        <property type="protein sequence ID" value="ENSCJPP00005000231.1"/>
        <property type="gene ID" value="ENSCJPG00005000316.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01020000230860"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008432">
        <property type="term" value="F:JUN kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005078">
        <property type="term" value="F:MAP-kinase scaffold activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007254">
        <property type="term" value="P:JNK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046328">
        <property type="term" value="P:regulation of JNK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047178">
        <property type="entry name" value="JIP1_scaffold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47437:SF2">
        <property type="entry name" value="C-JUN-AMINO-TERMINAL KINASE-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47437">
        <property type="entry name" value="JNK-INTERACTING PROTEIN 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="198"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="387"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="130"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="299"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="326"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="392"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="501"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="579"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005000231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1246" mass="131388" checksum="445AF21723B13BD9" modified="2022-01-19" version="1">MGPSPGGATQAPAPLPPPHFDSHGNGRTSAAPAEPPAQRSGEDVNRNVVCPAPQPSSPPSLVGIVAPACIAPQRRSPGVGGPASPRAQHNGPEPHEQPSAGGPAGRGEGLGTRTEPLSSDGEGPLGSAHGRPTGSSETTSPSSDPGIEADMTRHTTKGFPPGARHQGLSSPGSDSDVEGEMEAFGGRLLSNMISSISETELDLSSASSSGRSSHLTNSIEEASSPGSEGELEPELEAPGVMGIKGALLRDAGREEQEAPERRGSPAELKTEGYYDSLNPTDPSVPPEQTDVPSPSALHLELDPDHGLESVRRSFYLPVGPPLLPAADDDDNSEYDSDSESEPDLSEDSDSPWLLSNLVNKMISEGSYPIKCPDECFQQQHSLCDTISPASDLEPELSEALDAEPPGPEGLPHTPRPIELVDMETLRSSLQRAEDQRALGAGTEPPLEPNADESGPFLFMSNPTHDTIAPVFPGRPVSIERLGGNGDTTTNMATGCRGPISTKDSALSTKDSALSTKDSALNTKDSSFSTKDSALNTKDSSFSTKDSALNTKDSSFSTKDSALNTKDSSFSTKDSALNTKDSSFSTKDSSFSTKDSSFSTKDSVFSTVGSAAERSPPSGVPESLDLLDAVRLEPGGRDPPAMDVSTAKTNRCFNATYGTEEAAVSHLRPALFPEEPPPNLEARDESLAYDSVKYTLVVDENVQLELVSLRRCTSVLSDDSDLLRACERCHGDDDDAFGDGLEAPDVHSSAEDSSPEADLQFSKKFLNVFVNSTSRSSSECRRRARPCCAVPCRAMPCRAVPCCAVLCYAVYHAVLCAMLCAMPCRAVCHATLCAMPCCVPCYVPCYAMCHAMLCAVLHCVPCHAMPCCVPCYAVCHVMCHAMLCAMPCYVPCHAMCHVMCHAMLCAMPCHAVPCCVPCHAVCHAMLCAILCCVPCHAVCHAMLCAMPCCVPYYAVCHAVLCAVLCCVLCYAVCCAVLCAMPCYVPCHAVCHAMPCRAVCHAMPCRPVCHAILCAMPCHAVLCAMPYCVPCHAMPCCVPCYAVCHAMLCAMPCRAVCHGMLCAMPYCVPCHAVCHAMPCCVPCHAVCHAMLCAVLCCVPSYAVCHAMLCAMPCCVPCRAVCCAMLCHAMLLHAMLYHAMPCCAVLCCMGCAEPCCAAPCHAVLCHAAPCHAVLCHAVLCHAMLCCTVPCHAMLHCALLCHAAPCHAVLCCAAPCHAMLHRAMLCCAVLHHAIPCCAVLHHAMPCCVLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SR10</accession>
    <name>A0A8C2SR10_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Endoplasmic reticulum transmembrane helix translocase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Endoplasmic reticulum P5A-ATPase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">ATP13A1</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Endoplasmic reticulum translocase required to remove mitochondrial transmembrane proteins mistargeted to the endoplasmic reticulum. Acts as a dislocase that mediates the ATP-dependent extraction of mislocalized mitochondrial transmembrane proteins from the endoplasmic reticulum membrane. Specifically binds mitochondrial tail-anchored transmembrane proteins: has an atypically large substrate-binding pocket that recognizes and binds moderately hydrophobic transmembranes with short hydrophilic lumenal domains.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>[protein]-with a C-terminal TM segment(out) + ATP + H2O = [protein]-with a C-terminal TM segment(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66168"/>
            <dbReference type="Rhea" id="RHEA-COMP:16963"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:90782"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SR10"/>
    <dbReference type="Ensembl" id="ENSCJPT00005003233.1">
        <property type="protein sequence ID" value="ENSCJPP00005001866.1"/>
        <property type="gene ID" value="ENSCJPG00005001928.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107307010"/>
    <dbReference type="KEGG" id="cjo:107307010"/>
    <dbReference type="CTD" id="57130"/>
    <dbReference type="GeneTree" id="ENSGT00550000075064"/>
    <dbReference type="OrthoDB" id="48943at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140567">
        <property type="term" value="F:membrane protein dislocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015662">
        <property type="term" value="F:P-type ion transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140569">
        <property type="term" value="P:extraction of mislocalized protein from ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07543">
        <property type="entry name" value="P-type_ATPase_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000015">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000014">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000056">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057255">
        <property type="entry name" value="2TM_P5A-ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047820">
        <property type="entry name" value="P5A-type_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01657">
        <property type="entry name" value="P-ATPase-V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF7">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE HELIX TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23143">
        <property type="entry name" value="2TM_P5A-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1054"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1135"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1173"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="domain" description="P5A-ATPase transmembrane helical hairpin" evidence="22">
        <location>
            <begin position="46"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="21">
        <location>
            <begin position="295"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00059755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00067401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00083273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF23143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005001866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1206" mass="134420" checksum="B0BEF174F863C7A6" modified="2022-01-19" version="1">MRKCGSFLPEAEVSRLQAVLDKMAAAGPAPGLTDELVSSVTLYRRRPRLLHGTVLPFVAGLYPAWLWLWGPKVWAAVKEEEDGGQGPGPAPPEAALLALAAIGVVHLLTALSGLWSVHAHCALTCVREPSPKKATLAKVVPTPNNGSVELVPLHRDQDEDGQEALSFEFQKIKYSYEINGKKQFLPVAFPVEHPLCYYQNARGYQEDKDIRAAEKKYGTNKAEMVVPEFLELFKERATAPFFVFQVFCVGLWCLDEYWYYSVFTLSMLVAFEASLVQQQMRNMSEIRKMGNKPYMIQVYRNRKWRPISSDEIIPGDIVSIGRSPHENLVPCDVLLLRGRCIVDEAMLTGESVPQMKEPVEDLSPEHVLDMQTDARLHIIFGGTKVVQHIPPQKASTGLKPVDNGCVAYALRTGFNTSQGKLLRTILFGVKRVTANNLETFIFILFLLVFAIAAASYVWIEGTKDPSRNRYKLFLECTLILTSVVPPELPIELSLAVNTSLIALAKLYVYCTEPFRIPFAGKVEVCCFDKTGTLTSDHLVVRGVAGLRDGKEVTPVSDIPIETHRAIATCHSLVQLDDGTLVGDPLEKAMLTAVDWTLTKDEKVFPRSIKTQGLKIHQRFHFASALKRMSVLASYEKIGAADLCYIAAVKGAPETLHKMLSQCPSNYHAVHTEISHEGARVLALGYKELGHLTHQQVREMKREALECDLRFAGFIVVSCPLKTDSRSVIREIQNASHHVVMITGDNPLTACHVARELHFLQREHTLILQPPASKDSAWQWQSIDGTIVFPILPTSLRELTQRYDLCVTGEGLSHLQALNRQQLLRLIPHVQVFARVVPKQKEFVITTLKSLGYVTLMCGDGTNDVGALKHADVGVALLANAPERLPERKKRPRDGPTELRPAAVTLGSATVKPTSRGAKHRVMSQREEQLAMQRERISQVLKDLEEDRVPVVKLGDASIAAPFTSKLSSIQCICHVIKQGRCTLVTTLQMFKILALNALILAYSQSVLYLEGVKFSDFQATLQGLLLAGCFLFISRSKPLKTLSKERPLPNIFNLYTVLTVLLQFLVHFLSLVYLYHGAQVRSASKREEFVDLYKEFEPSLVNSTVYIMSMAMQMATFAINYKGHPFMESLQENKPLLWSIILSGLAIVGLLTGSSPEFNEQFGLVEIPTEFKLVITEVLLADFFLALLADRILQFLLGRAKLKVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SRJ0</accession>
    <name>A0A8C2SRJ0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SUMO-activating enzyme subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Ubiquitin-like 1-activating enzyme E1A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">SAE1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterodimer of SAE1 and UBA2/SAE2. The heterodimer corresponds to the two domains that are encoded on a single polypeptide chain in ubiquitin-activating enzyme E1. Interacts with UBE2I.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SRJ0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005002940.1">
        <property type="protein sequence ID" value="ENSCJPP00005001747.1"/>
        <property type="gene ID" value="ENSCJPG00005001747.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00550000075007"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031510">
        <property type="term" value="C:SUMO activating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043008">
        <property type="term" value="F:ATP-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044388">
        <property type="term" value="F:small protein activating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019948">
        <property type="term" value="F:SUMO activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033235">
        <property type="term" value="P:positive regulation of protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000011">
        <property type="entry name" value="UBQ/SUMO-activ_enz_E1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF162">
        <property type="entry name" value="SUMO-ACTIVATING ENZYME SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01849">
        <property type="entry name" value="UBIQUITINACT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034555512" description="SUMO-activating enzyme subunit 1" evidence="10">
        <location>
            <begin position="17"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="11">
        <location>
            <begin position="14"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="223"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00026003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005001747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="258" mass="28643" checksum="4BFED3F78D459144" modified="2022-01-19" version="1">MGSLWGYRGSLWGLRASRVLLVGLRGLGAEVAKNLILAGVKGLTMMDHQQVSPEDTRAQFLVPAGSVGRNRAEASLERAQNLNPMVDVKADPENVESKPEAFFTQFDAVCVTGCSRDAMMRIDHICHQNGIKFFAGDVFGYHGYTFADLGEHDFVEEKTKVTKANNPTVDDGPGAKRAKVDPNETTMVKKRIHFCPLKDALNLDWNNEQIQAAMKRTSPDFFLLQAGTPPKTETQNPRTPQDKRPPDKPVESQTHRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SRX4</accession>
    <name>A0A8C2SRX4_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SRX4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005003377.1">
        <property type="protein sequence ID" value="ENSCJPP00005001939.1"/>
        <property type="gene ID" value="ENSCJPG00005002028.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01050000244936"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019814">
        <property type="term" value="C:immunoglobulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:002198">
        <property type="entry name" value="Immunoglobulin heavy variable 5-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050199">
        <property type="entry name" value="IgHV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23266">
        <property type="entry name" value="IMMUNOGLOBULIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="1" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-1280">Immunoglobulin</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005001939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="140" mass="14876" checksum="163771F441ABDCAF" modified="2022-01-19" version="1">GFLPQNRAELGPAGADLVCKGSGFTFSDYGMEWVRQAPGKGLEYVAGITGAGGYTEYGPAVQGRATIMRDNGQSTVRLQLNSLKDEDSAMYYCAKSAYSSGGFGASYMDGTCALISSIMVMVINMVMVMVMVMAMVISHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SSL3</accession>
    <name>A0A8C2SSL3_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">KIF-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">KIF1-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">KIFBP</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Activator of KIF1B plus-end-directed microtubule motor activity. Required for organization of axonal microtubules, and axonal outgrowth and maintenance during peripheral and central nervous system development.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KIF-binding protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SSL3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005005756.1">
        <property type="protein sequence ID" value="ENSCJPP00005003190.1"/>
        <property type="gene ID" value="ENSCJPG00005003428.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107315762"/>
    <dbReference type="KEGG" id="cjo:107315762"/>
    <dbReference type="CTD" id="26128"/>
    <dbReference type="GeneTree" id="ENSGT00390000013819"/>
    <dbReference type="OrthoDB" id="409897at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019894">
        <property type="term" value="F:kinesin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140311">
        <property type="term" value="F:protein sequestering activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021952">
        <property type="term" value="P:central nervous system projection neuron axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047497">
        <property type="term" value="P:mitochondrion transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990535">
        <property type="term" value="P:neuron projection maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022083">
        <property type="entry name" value="KBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46321:SF1">
        <property type="entry name" value="KIF-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46321">
        <property type="entry name" value="KIF1-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12309">
        <property type="entry name" value="KBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005003190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="595" mass="69348" checksum="0F3338257A96CD5E" modified="2022-01-19" version="1">MAAAGGWWAAACEKFRNAKTLSDVESRKDPETEPYRSKYSARALLQEVKQQLSAAEDCSEPRLLAVRRAVLEFELGVNHTDTEELSAGEEHLQRCTQLLEPHRLNRDCVSLYIQAQNNLGILWSERDEIKTGQTYLESAEALYNQYMKEDGNPPLDPSEHFMAEGEEKLTDQERSKRFEKAYTHTLYYLAQVYQHLEMTEKAAQYCHTTLKRQLEYCGYYPVEWALNAATLSQYYLSKQCFMESRHCLAAASVIFSQAGQVPSSEDNETEQEQQDLRQRKAEIARCWIKYCLNLLQSARKLLEDNVGELDPDRQLELKAQRKKEEDEKENGRKKAVLFGTSDICDSVLAMEEKVSSLYPLDFQEAREIFLVGQNYVQEAKEFFQVDGYVTDHIQIVQDHSALFKVLAFFEEDYERRCKMHKRRIDMLEPLYADLNPQYYLLITRQLQFELADTYYEMMDLKVAIGNRLEELDSHTIKKINSLAQLAIKYYELFLDSLRSPDKVFPEELEEDVLRPAMVAKFHIARLYGKIITSDSKKQLENMQLSFVYYMFLVNYCEKHPDAVHAIETELELSKEMVGLLPARMERLRAKLCPFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SSN2</accession>
    <name>A0A8C2SSN2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Potassium voltage-gated channel subfamily B member 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="28">Voltage-gated potassium channel subunit Kv2.1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="36" type="primary">KCNB1</name>
    </gene>
    <organism evidence="36 37">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="36" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="36" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="36" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <location evidence="2">Sarcolemma</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cell projection</location>
            <location evidence="6">Axon</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cell projection</location>
            <location evidence="4">Dendrite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Lateral cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Perikaryon</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="29">Postsynaptic cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="30">Synapse</location>
            <location evidence="30">Synaptosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the potassium channel family. B (Shab) (TC 1.A.1.2) subfamily. Kv2.1/KCNB1 sub-subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015737157.1">
        <property type="nucleotide sequence ID" value="XM_015881671.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SSN2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005004098.1">
        <property type="protein sequence ID" value="ENSCJPP00005002263.1"/>
        <property type="gene ID" value="ENSCJPG00005002468.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107322997"/>
    <dbReference type="KEGG" id="cjo:107322997"/>
    <dbReference type="CTD" id="3745"/>
    <dbReference type="GeneTree" id="ENSGT00940000154899"/>
    <dbReference type="OrthoDB" id="296522at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032590">
        <property type="term" value="C:dendrite membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016328">
        <property type="term" value="C:lateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032809">
        <property type="term" value="C:neuronal cell body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043204">
        <property type="term" value="C:perikaryon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005251">
        <property type="term" value="F:delayed rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044325">
        <property type="term" value="F:transmembrane transporter binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090314">
        <property type="term" value="P:positive regulation of protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18412">
        <property type="entry name" value="BTB_POZ_KCNB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000034">
        <property type="entry name" value="Potassium voltage-gated channel subfamily B member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000018">
        <property type="entry name" value="Potassium voltage-gated channel subfamily B member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000010">
        <property type="entry name" value="Potassium voltage-gated channel subfamily B member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003968">
        <property type="entry name" value="K_chnl_volt-dep_Kv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003973">
        <property type="entry name" value="K_chnl_volt-dep_Kv2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004350">
        <property type="entry name" value="K_chnl_volt-dep_Kv2.1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF63">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY B MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03521">
        <property type="entry name" value="Kv2channel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01514">
        <property type="entry name" value="KV21CHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01491">
        <property type="entry name" value="KVCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01495">
        <property type="entry name" value="SHABCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="26" id="KW-0966">Cell projection</keyword>
    <keyword evidence="32" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="27" id="KW-0407">Ion channel</keyword>
    <keyword evidence="23" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="24 34" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="20" id="KW-0630">Potassium</keyword>
    <keyword evidence="17" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="13" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="37" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="22" id="KW-0770">Synapse</keyword>
    <keyword evidence="15" id="KW-0771">Synaptosome</keyword>
    <keyword evidence="16 34" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="21 34" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <keyword evidence="18" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="19" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="34">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="34">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="34">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="34">
        <location>
            <begin position="363"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="34">
        <location>
            <begin position="392"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="35">
        <location>
            <begin position="31"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="33">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="33">
        <location>
            <begin position="489"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="33">
        <location>
            <begin position="537"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="32">
        <location>
            <begin position="134"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="33">
        <location>
            <begin position="504"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="33">
        <location>
            <begin position="537"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00008292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00015829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00031679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00034100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00034102"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="35">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="36">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005002263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="37">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="863" mass="96993" checksum="DC3346E3AC1C9D27" modified="2022-01-19" version="1">MPLGMNKHGSRSTTSLPPDPTEIVRSKACSRRVKLNVGGLAHEVLWRTLDRLPRTRLGKLRDCNTHDSLMEICDDYNLEENEYFFDRHPGAFTSILNFYRTGKLHMMEEMCALSFSQELDYWGVDEIYLESCCQARYHQKKEQMNEELKREAETLREREGEEFDNTCCADKRKKLWDLLEKPNSSVAAKILAIISIMFIVLSTIALSLNTLPELQGVDEFGQTTDNPQLAHVEAVCIAWFTMEYLLRFLSSPKKWKFFKGPLNAIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFRIMRILRILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEKDEDDTKFKSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKEQKRQEKAIKRREALERAKRNGSIVSMNMKDAFARSIELMDIVVEKNGESIAKKDKVQDNHLSPNKWKWTKRTLSETSSSKSFETKEQGSPEKARSSSSPQHLNVQQLEDMYNKMAKTQSQPNLNTKETSQSGKQMEELEMETLPGPMVPLLTTRTDGIIDMRSMSSIDSFISCAAEFPDSGRFSHSPLATLPCKGGINVIQEQSRAEGSSARFADINTSSEGSHRSAFFIESPKSSIKASNPLKLRSLKVNFMEEDASTLVPASNVLRIYPDTLKSRGATAATGTDTSLLSDRSLMSPETSIYTTASARTPPKSPETQTAIAFNFHDAGIHKYIDADTDDEGQLLYDSSPPGNVSPKYNITNIGYLKQKDNVYRTEKNHLEAAALPTSPKLIGQNCIYSMEGITGRTQGNQETVRLENHISPEVHVLPGSGGHANTHDQSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SU62</accession>
    <name>A0A8C2SU62_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat domain 49</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ANKRD49</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SU62"/>
    <dbReference type="Ensembl" id="ENSCJPT00005006694.1">
        <property type="protein sequence ID" value="ENSCJPP00005003862.1"/>
        <property type="gene ID" value="ENSCJPG00005003958.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000003919"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000437">
        <property type="entry name" value="Lethal (2) 35Be"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="85"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="118"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005003862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="216" mass="24835" checksum="C053A54B63571397" modified="2022-01-19" version="1">GDRTRGNGQKLEHRKFHMNVHKNFFMVRVTEHWNRLPRGLWSLLLWRYSSPTWMPVSVTWCREPLTTVRRLLSEKLAPVNARDEDQYTPLHRASYSGHLDMAQELVAHGADIHAQTVDGWTPLHSACKWNNTEVAAFLLQQGADINAQTNGLLTPLHIAAGNKNSRETLELLLMNRYIKADLKNNLDETALDIARRTDIYHYLFEIVEDCINAVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SWC5</accession>
    <name>A0A8C2SWC5_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Histone-lysine N-methyltransferase</fullName>
            <ecNumber evidence="17">2.1.1.355</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">SUV39H2</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60276"/>
            <dbReference type="Rhea" id="RHEA-COMP:15538"/>
            <dbReference type="Rhea" id="RHEA-COMP:15546"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.355"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 17">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.355" evidence="17"/>
    <dbReference type="RefSeq" id="XP_015730109.1">
        <property type="nucleotide sequence ID" value="XM_015874623.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SWC5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005007950.1">
        <property type="protein sequence ID" value="ENSCJPP00005004825.1"/>
        <property type="gene ID" value="ENSCJPG00005004689.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107319605"/>
    <dbReference type="KEGG" id="cjo:107319605"/>
    <dbReference type="CTD" id="79723"/>
    <dbReference type="GeneTree" id="ENSGT00940000156788"/>
    <dbReference type="OrthoDB" id="308383at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140949">
        <property type="term" value="F:histone H3K9 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990756">
        <property type="term" value="F:ubiquitin-like ligase-substrate adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071456">
        <property type="term" value="P:cellular response to hypoxia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044725">
        <property type="term" value="P:epigenetic programming in the zygotic pronuclei"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd18639">
        <property type="entry name" value="CD_SUV39H1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10532">
        <property type="entry name" value="SET_SUV39H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.270.10:FF:000008">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.40:FF:000016">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
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    <keyword evidence="10 17 19" id="KW-0862">Zinc</keyword>
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    </evidence>
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    <sequence length="407" mass="46647" checksum="9C378E8B541A96BF" modified="2022-01-19" version="1">MEGWRGAWYVPCLASRETLQELCRKENLICKSIGITNKSLKTYEVEYLCDYKVEEGKEYYLVKWKGWPESSNTWEPQKNLKCPKLLENFLSDKDEYLSRMKGGRALKVRNSVKALKPAVADYIVKKAKQRIALQRWKEELNRKKNHRGMILVENTVDLEGPPIDFYYINEYKPAPGINVINGITTGCECSDCPAEKCCPKEAGFILAYNKRRKLKIQPGLPIYECNSFCRCGPDCPNRIVQKGTQYSLCIFRTNNGRGWGVKTLQKINTNSFVMEYVGEVITSEEAERRGQFYDNQGNTYLFDLDYDSDEFTVDAARYGNVSHFVNHSCDPNLQVFNVFIDNLDLRLPRIALFSTRTIKAGEELTFDYQMKGSIDLTSDSADGLSSSRKRIRTVCKCGAVCCRGYLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SWW9</accession>
    <name>A0A8C2SWW9_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Probable arginine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Arginyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">RARS2</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the attachment of arginine to tRNA(Arg) in a two-step reaction: arginine is first activated by ATP to form Arg-AMP and then transferred to the acceptor end of tRNA(Arg).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>tRNA(Arg) + L-arginine + ATP = L-arginyl-tRNA(Arg) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="3"/>
    <dbReference type="RefSeq" id="XP_015714383.1">
        <property type="nucleotide sequence ID" value="XM_015858897.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SWW9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005007172.1">
        <property type="protein sequence ID" value="ENSCJPP00005004242.1"/>
        <property type="gene ID" value="ENSCJPG00005004258.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107311955"/>
    <dbReference type="KEGG" id="cjo:107311955"/>
    <dbReference type="CTD" id="57038"/>
    <dbReference type="GeneTree" id="ENSGT00530000063407"/>
    <dbReference type="OrthoDB" id="68056at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00671">
        <property type="entry name" value="ArgRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000006">
        <property type="entry name" value="Arginyl-tRNA synthetase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000058">
        <property type="entry name" value="Mitochondrial arginyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.70:FF:000004">
        <property type="entry name" value="Probable arginine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="entry name" value="Arginyl tRNA synthetase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00456">
        <property type="entry name" value="argS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956:SF11">
        <property type="entry name" value="ARGININE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="ARGINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="12 17" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 17" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 17" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="DALR anticodon binding" evidence="19">
        <location>
            <begin position="497"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00033033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005004242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="612" mass="68730" checksum="A765AA3C31C4E4A6" modified="2022-01-19" version="1">MADTAPPQSMEWSRPQEAERRGQGAVLTSYNSTMAACAFRRSIAGQLAKVLDLPPENLIKSISAVPVSRKRHDADFQLSVASIEEGSSSDCLAQDLQLRAQKLAEKLKCDAVVSEISTGPGTVNFTINRELLAKTVLQQVLKDGTQYGTKSELFSAVPKQKTVVEFSSPNIAKKFHIGHLRSTIIGNFIANLKAALGHEVTRINYLGDWGMQFGLLGVGFQQFGDKEKLKSSPLQHLFEVYVQINKAAADENTKKLAMDFFRKLEEHDEQALSLWKEFRDFSIKEYTQIYKRLGVHFDEYSGESFYHEKSREVLKMLEDKGLLQKTIKGTGVVDLSEKKDLSSLSTVIRSDGTSLYITRDLAAAIDRMNKYNWDTMIYVTDRNQSSHFQHLFRILKLMGYDWVDRCQHVSFGLVQGMKTRKGEVIFLEDVLDEVRSRMLENMASAKTTKEVEDPVETAEKVGLAALIIQDFRGLLSSDYQFSWDRALQSRGDTGVFLQYTHARLHSLEQMHGNEPVTDVNVACLQEPGAISVLQHLLRYDEVLYRSSQDLQPKHIVSYLLTLSHLAAVAHRSLPVKGSTPAVAQARLCLFQATRSVLANGMKLLGITPVTRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SXR9</accession>
    <name>A0A8C2SXR9_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transmembrane protein 123</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">TMEM123</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CD164 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SXR9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005006342.1">
        <property type="protein sequence ID" value="ENSCJPP00005003616.1"/>
        <property type="gene ID" value="ENSCJPG00005003755.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063929"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007947">
        <property type="entry name" value="CD164_MGC24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11337">
        <property type="entry name" value="MUCIN/PORIMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11337:SF14">
        <property type="entry name" value="PORIMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05283">
        <property type="entry name" value="MGC-24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="85"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="94"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="120"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005003616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="245" mass="24963" checksum="42A9B80B53B7AC4D" modified="2022-01-19" version="1">MAAPSRSGRAVPPLPPLGPAQPRSAPRGPASLGVLQPSQHRPAASEAMRLFFPGAACALQAVTLLFLLGPLGNAFAELNVTNTSSNVTSSPVVQGNSTSSSLSAVPTTQSAAGTPTSAGHPTNASHPTSTSHPTSASHPTSTTAHVTVPPQPAETNQTGSTTASSVTSSQVNVTVTTSKISVTSVTATSKSETVVARASRFDVGSFVGGIVLTLCVLVILYIGCKTYHSRRGIQYRTIDEHDAII</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SYG0</accession>
    <name>A0A8C2SYG0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Binds to extracellular matrix proteins. Binds to pathogen-associated molecular patterns (PAMPs) present on the cell walls of Gram-positive and Gram-negative bacteria and fungi, behaving as a pattern recognition receptor (PRR). Induces bacterial and fungal aggregation and subsequent inhibition of PAMP-induced cytokine release. Does not possess intrinsic bactericidal activity. May play a role in the innate defense and homeostasis of certain epithelial surfaces.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with LGALS1 and laminin.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SYG0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005008001.1">
        <property type="protein sequence ID" value="ENSCJPP00005004869.1"/>
        <property type="gene ID" value="ENSCJPG00005004717.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000164475"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome LGE64"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000003">
        <property type="entry name" value="Deleted in malignant brain tumors 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000001">
        <property type="entry name" value="Lysyl oxidase 4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000019">
        <property type="entry name" value="Neurotrypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000006">
        <property type="entry name" value="neurotrypsin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000007">
        <property type="entry name" value="Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19331">
        <property type="entry name" value="SCAVENGER RECEPTOR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19331:SF487">
        <property type="entry name" value="SOLUBLE SCAVENGER RECEPTOR CYSTEINE-RICH DOMAIN-CONTAINING PROTEIN SSC5D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00420">
        <property type="entry name" value="SRCR_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 9" id="KW-1015">Disulfide bond</keyword>
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    <keyword evidence="2" id="KW-0677">Repeat</keyword>
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        </location>
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            <begin position="49"/>
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    <sequence length="1033" mass="111857" checksum="B3608E8A1B4BBB25" modified="2022-01-19" version="1">MSITFLMPISVCFSGSRISNISALRLVDGLSECAGRVEVKYNNEWGTVCDDFWDMSDAAVVCRQLGCGTALSAPGSARFGWGYSRIWLDDVSCTGEENDISQCAAKTWGVHNCHHGEDAGVVCSGNLSSVDVRLVNGPSRCAGRVEVLHNGQWGTVCDDGWDLNDAKVVCRQLGCGTVMSAPGRAHFGQGTGYIWLDDVSCTGIEDALPHCQARPWGQNNCNHREDAGVVCLGKSCNMGPALCSRILEFIEGSALLKAMQRLFCPTARIHRTAPYRDRTCSGFEPAVCACSSERQLYPGLHNKKCGQHGEGGDCSPLLCFCETLHTVLGPNRCAGRVEVLHDGQWGTVCDDGWNLQAATVVCRQLNCGRAESAPSGARFGQGTGHIWLDDVNCAGTEDALHECRARPWGMNNCNHREDAGVVCSGQLSPAKQVRLVDGPHRCAGRLEVFQNERWGTVCGNGWDMNDAIVVCRQLGCGIALSAPVQAHFGQGSDPIWMNRVSCIGTESSISECLSSPWGIQLCTHMDDAGVECSDDTSTLRLVNGPHRCSGRVEVFHNQQWGTVCDDGWDMSDAMVVCRQLGCGEALSATTRASFGQGVDPIWLDRVACTGRENALIQCRARPWGVNVCTHEEDAGVVCSVEAAEIRLVNGPSRCAGRVEVLHDGQWGTVCDDDWNIQAATVVCRQLNCGRAESASRGARFGQGTGHIWLDDVNCAGTEDALHECRARPWGMNNCNHREDAGVVCSGQLKETQIRLVNGPNRCAGRVEVFHSGQWGTVCDDSWNLRSAKVVCRQLGCGTAISAPGKAHFGRGSDVIWLDDVECSGTEASLSQCRLNNWGNHNCNHEEDAAVVCSGTNPFQVRLRDSSSPCAGHVEVRYNTTWYSICDKSWSSLEAEVVCKQLGCGPAQTENAGIRVGQNHNYVFLEGLQCRGAETLLLECQQNKIGPGACQHGVAAGVVCTEPRGECQNPPSAAVGRAAQGLDAALSLQKERYKCCGTCLSEQAFPWWTLFSTKNEPNYHWLEHQKCFSDLRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SYL8</accession>
    <name>A0A8C2SYL8_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">tRNA (guanine(37)-N1)-methyltransferase</fullName>
            <ecNumber evidence="11">2.1.1.228</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">M1G-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA [GM37] methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA methyltransferase 5 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">TRMT5</name>
        <name evidence="11" type="synonym">TRM5</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in mitochondrial tRNA methylation. Specifically methylates the N1 position of guanosine-37 in various tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>guanosine(37) in tRNA + S-adenosyl-L-methionine = N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36899"/>
            <dbReference type="Rhea" id="RHEA-COMP:10145"/>
            <dbReference type="Rhea" id="RHEA-COMP:10147"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.228"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion matrix</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="11">Predominantly in the mitochondria and in the nucleus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the TRM5 / TYW2 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.228" evidence="11"/>
    <dbReference type="RefSeq" id="XP_015721273.1">
        <property type="nucleotide sequence ID" value="XM_015865787.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SYL8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005009262.1">
        <property type="protein sequence ID" value="ENSCJPP00005005765.1"/>
        <property type="gene ID" value="ENSCJPG00005005460.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107315422"/>
    <dbReference type="KEGG" id="cjo:107315422"/>
    <dbReference type="CTD" id="57570"/>
    <dbReference type="GeneTree" id="ENSGT00940000153304"/>
    <dbReference type="OrthoDB" id="408788at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052906">
        <property type="term" value="F:tRNA (guanine(37)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070901">
        <property type="term" value="P:mitochondrial tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002939">
        <property type="term" value="P:tRNA N1-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.110:FF:000001">
        <property type="entry name" value="tRNA (guanine(37)-N1)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000102">
        <property type="entry name" value="tRNA (guanine(37)-N1)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.110">
        <property type="entry name" value="Met-10+ protein-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03152">
        <property type="entry name" value="TRM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030382">
        <property type="entry name" value="MeTrfase_TRM5/TYW2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056743">
        <property type="entry name" value="TRM5-TYW2-like_MTfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056744">
        <property type="entry name" value="TRM5/TYW2-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025792">
        <property type="entry name" value="tRNA_Gua_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245:SF36">
        <property type="entry name" value="TRNA (GUANINE(37)-N1)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245">
        <property type="entry name" value="TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02475">
        <property type="entry name" value="TRM5-TYW2_MTfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25133">
        <property type="entry name" value="TYW2_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51684">
        <property type="entry name" value="SAM_MT_TRM5_TYW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="SAM-dependent methyltransferase TRM5/TYW2-type" evidence="12">
        <location>
            <begin position="208"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="335"/>
            <end position="336"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="363"/>
            <end position="364"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="395"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005005765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="510" mass="57703" checksum="86C989F16EEF0491" modified="2022-01-19" version="1">MFEAARFDDAGLGMRILWRFGCSARLLQTNHYRTAASNPSFPAVWMLLARHPVRIPALFAVFHNRIHTMPETTQHNPNPELYSPHPDVRGMTLLNREAFKRTVVVPALKVKKEIVHTLLKSLKHAVLQRPGLKRVVEDPEDEDSKLVILDPQKIPEFSLGESEKEVLKQLHVNPEVSKYNLELTYENFKSDEILRAVLPEGQDVTSGFSRVGHIAHLNLRDHQLPYRHLIGQVIVDKNPGITCVVNKTSIIDSTYRNFQMEVLAGESNLVTKVKENNFTYELDFAKVYWNPRLSTEHGRIVELLKPGDVLFDVFAGIGPFAIPAAKKKCVVFANDLNPESYRWLLHNCKLNKVDSKIKAFNMDGRDFILGPVREELRKELALVKEQKTAFHIVMNLPALAIEFLDVFRHLLVGEPCSAAVLPTVHCYGFSKHENPAKDIQERAEAALGASLEGRCSTYLVRNVAPNKEMLCITFQIPADVLYKRPCPAGDKPASKRLRTCQDVTEEGLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SZI9</accession>
    <name>A0A8C2SZI9_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized LOC107305738</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC107305738</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015703740.1">
        <property type="nucleotide sequence ID" value="XM_015848254.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SZI9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005009445.1">
        <property type="protein sequence ID" value="ENSCJPP00005005924.1"/>
        <property type="gene ID" value="ENSCJPG00005005600.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107305738"/>
    <dbReference type="KEGG" id="cjo:107305738"/>
    <dbReference type="GeneTree" id="ENSGT00530000067979"/>
    <dbReference type="OrthoDB" id="9899510at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome Z"/>
    </dbReference>
    <dbReference type="CDD" id="cd23412">
        <property type="entry name" value="beta-trefoil_Ricin_unchar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052678">
        <property type="entry name" value="OST-beta_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36129">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER SUBUNIT BETA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36129:SF2">
        <property type="entry name" value="RICIN B LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034663695" evidence="3">
        <location>
            <begin position="23"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="4">
        <location>
            <begin position="22"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005005924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="341" mass="38251" checksum="FAEDDEEE35DDD3FC" modified="2022-01-19" version="1">MELLRLSLSCICLLPWLEVAEGQGFLIRNTRLEKCIHVSHHEADGIVLAECMPHSQQQQWSWDPASGTITSLQTKQCLSAHRTREYGLAKMEPCGNREHQVWACSKKGHLTLQSLGFHLSTKDGGHKVFVSRKKDKFSRWKTLEDETICAAATLRPAESVRGVVDTRVWIYESKTIDSSKTDAMEKESSVGLTDSPLVNKLNSTVVPVKTKQAYLPEREDVLYNHSKKHHGNRGKTSGARLAGTNWKTAMLVLSPLAFILGLIILTLNVHYNKKKKILSALKNPPASSNRADLQETSPLRRCPQPYLPPSRSPSLRHGEILIEWKDGTVTPLFDNANYQVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SZM1</accession>
    <name>A0A8C2SZM1_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase like 27</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">METTL27</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015736522.1">
        <property type="nucleotide sequence ID" value="XM_015881036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SZM1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005007340.1">
        <property type="protein sequence ID" value="ENSCJPP00005004399.1"/>
        <property type="gene ID" value="ENSCJPG00005004343.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107322709"/>
    <dbReference type="KEGG" id="cjo:107322709"/>
    <dbReference type="CTD" id="155368"/>
    <dbReference type="GeneTree" id="ENSGT00530000063975"/>
    <dbReference type="OrthoDB" id="3647at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF101">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="66"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005004399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="235" mass="25615" checksum="2341992820A5FEB8" modified="2022-01-19" version="1">MQLSAGVRERVAAVHRGAGLSELLQRYDGWAGRYERDVAALDYRAPYLAVASLAFAFPSPPAEALVLDVACGTGLVARELHRRGFRRLHGVDGSAGMLELARGTGLYVQLQRCVLGREPLPAPAGRYDAVTLVGALGEGQVPSSALPELLRVTRAGGFLCMTTRCNPSNRRYRAELEAALRDLEQKGAWQRVLEQEVPRWERATSEEEENGPGSGYISGVIYIYRKCPVPPPELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T3U5</accession>
    <name>A0A8C2T3U5_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T3U5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005010624.1">
        <property type="protein sequence ID" value="ENSCJPP00005006813.1"/>
        <property type="gene ID" value="ENSCJPG00005006296.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000237759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23794">
        <property type="entry name" value="UBCc_UBE2F_UBE2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="5">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="129" mass="13779" checksum="08125BC83B6CE073" modified="2022-01-19" version="1">MVYHPNIDLEGNVCLNILREDWKPVLTINSIIYGLQYLYETLETGVWEACRGLWGPIGVYGPVGPLRASNGGHMRGRGGGLVGGLLGTCMEGVSVGPVLGGLWGPRGLVGAVWGYHAGPRGHNESERPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T3U7</accession>
    <name>A0A8C2T3U7_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Regulator of chromosome condensation 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">RCC2</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Chromosome</location>
            <location evidence="4">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Midbody</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_032304666.1">
        <property type="nucleotide sequence ID" value="XM_032448775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T3U7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005012420.1">
        <property type="protein sequence ID" value="ENSCJPP00005008142.1"/>
        <property type="gene ID" value="ENSCJPG00005007335.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107323507"/>
    <dbReference type="KEGG" id="cjo:107323507"/>
    <dbReference type="CTD" id="55920"/>
    <dbReference type="GeneTree" id="ENSGT00940000156151"/>
    <dbReference type="OrthoDB" id="297375at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034506">
        <property type="term" value="C:chromosome, centromeric core domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072356">
        <property type="term" value="P:chromosome passenger complex localization to kinetochore"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045184">
        <property type="term" value="P:establishment of protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048041">
        <property type="term" value="P:focal adhesion assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051895">
        <property type="term" value="P:negative regulation of focal adhesion assembly"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900025">
        <property type="term" value="P:negative regulation of substrate adhesion-dependent cell spreading"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051987">
        <property type="term" value="P:positive regulation of attachment of spindle microtubules to kinetochore"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010762">
        <property type="term" value="P:regulation of fibroblast migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900027">
        <property type="term" value="P:regulation of ruffle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.30:FF:000022">
        <property type="entry name" value="RCC2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.30:FF:000009">
        <property type="entry name" value="Regulator of chromosome condensation 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028641">
        <property type="entry name" value="RCC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46207">
        <property type="entry name" value="PROTEIN RCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46207:SF1">
        <property type="entry name" value="PROTEIN RCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="RCC1-like" evidence="19">
        <location>
            <begin position="114"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="17">
        <location>
            <begin position="177"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="17">
        <location>
            <begin position="229"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="17">
        <location>
            <begin position="281"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="17">
        <location>
            <begin position="357"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="17">
        <location>
            <begin position="456"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="18">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="18">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
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        <source>
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        </source>
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        </source>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
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        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005008142.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="530" mass="56653" checksum="ABDBB7D35B19E497" modified="2022-01-19" version="1">MPRRKAAGPPWEPGPGRRRPGAAGGRRRPRNGGGGGGSSGGSSDDEAPPERRPRDGSPGGGGGRRPGRPSAPGSGSALGPGPGGAARGQAVVICEPEHSKERIKLEGSKCRGQLLIFGATNWDLIGRKEVPKQQAAYRNLGQNLWGPHRYGCLSGIQVRTVVSGPCAAHSLLITAEGKLWSWGRNEKGQLGHGDTKRVEAPKLIEVLGSEAIVLAACGRNHTLALTESGSVYAFGENKMGQLGLGNQTDAVPSPTQIMYNGQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGAAQIYAGYTCSFAVSETGGLFFWGATNTSRESTMYPKAVQDLCGWKIRSLACGKSSIIVAADESTISWGPSPTFGELGYGDHKPKSSTAAQEVKTLDGIYTEQVAMGYAHSLVIARDESDAEKEKLRKLPEYNPRTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T3X1</accession>
    <name>A0A8C2T3X1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">HERPUD2</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Could be involved in the unfolded protein response (UPR) pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T3X1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005011305.1">
        <property type="protein sequence ID" value="ENSCJPP00005007296.1"/>
        <property type="gene ID" value="ENSCJPG00005006731.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000017671"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd17119">
        <property type="entry name" value="Ubl_HERP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000046">
        <property type="entry name" value="Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039751">
        <property type="entry name" value="HERPUD1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12943:SF5">
        <property type="entry name" value="HOMOCYSTEINE-RESPONSIVE ENDOPLASMIC RETICULUM-RESIDENT UBIQUITIN-LIKE DOMAIN MEMBER 2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12943">
        <property type="entry name" value="HOMOCYSTEINE-RESPONSIVE ENDOPLASMIC RETICULUM-RESIDENT UNIQUITIN-LIKE DOMAIN HERPUD PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0834">Unfolded protein response</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="10">
        <location>
            <begin position="10"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="85"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="87"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="123"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005007296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="434" mass="48028" checksum="353CE56837A7B5F0" modified="2022-01-19" version="1">MEQGVVGHPVTLIIKAPNQKYTDQTISCFLDWTVGRLKSHLSDVYPSKPSTKDQRLVYSGRLLPDHLQLKDVLRKQDEYHMVHLVCTSRTPPSSPKPSTSRGGHGASTSSSSSSLDHTGSNTASPTNQEASSTSLNTSADGMRHRNLPQAQSDPIPSHQFPYVMQGNLGNQFPGQAIPAGFPVYPAFSPFQMIWWQQMYARQYYMQYQAAVSAQVTSSTEPVRSAVAQAVNSQRAPANEQHAAVPNVAIQENRPVNPNVQMNAQGGPVVNEEDFNRDWLDWMYTFSRAAILLSIVYFYSSFSRFVMVMGAMLLVYLHQAGWFPFRQEGGQQQAPNNVEGNRDGQNANNPDLEEMERLMDDGIDEDSGEDAGEDANVEQQPGFMASAWSFITTFFTSLIPEGPPQIQWSSIQSSGCRAPPFVQSFSRGTSLIYSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T4R9</accession>
    <name>A0A8C2T4R9_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Melanocortin receptor 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">MC5R</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. This receptor is a possible mediator of the immunomodulation properties of melanocortins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T4R9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005012893.1">
        <property type="protein sequence ID" value="ENSCJPP00005008523.1"/>
        <property type="gene ID" value="ENSCJPG00005007596.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01140000282542"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004977">
        <property type="term" value="F:melanocortin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd15354">
        <property type="entry name" value="7tmA_MC5R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000077">
        <property type="entry name" value="Melanocortin receptor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001908">
        <property type="entry name" value="MC3-5R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000621">
        <property type="entry name" value="Melancort_rcpt_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001671">
        <property type="entry name" value="Melcrt_ACTH_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22750">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00534">
        <property type="entry name" value="MCRFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00535">
        <property type="entry name" value="MELNOCORTINR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01063">
        <property type="entry name" value="MELNOCORTN5R"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 12" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="233"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="101"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005008523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="373" mass="42556" checksum="964A9461DB818C07" modified="2022-01-19" version="1">MVDICFVNFCLFLSRSIFFGRVFCLLENAFTTLLGKSLRENRKCLLPDMNTSSQLYVSELNLSAFGSNFTVPTVKSKSSPCEQVVIAAEVFLTLGIVSLLENILVICAIVKNKNLHSPMYFFVCSLAVADMLVSVSNAWETITIYLINNRHIIMEDAFVRHIDNVFDSLICISVVASMCSLLAIAVDRYITIFYALRYHNIMTVKRSGLIIACIWTFCTGCGIIFILYYESTYVIICLITMFFTMLFLMVSLYIHMFLLARTHVKKIAALPGYNSVHQRTSMKGAITLTMLLGIFIVCWAPFFLHLILMISCPQNLYCVCFMSHFNMYLILIMCNSVIDPLIYAFRSQEMRKTFKEIICCYSVRMVCGLSNKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T504</accession>
    <name>A0A8C2T504_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cilia-and flagella-associated protein 96</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">CFAP96</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CFAP96 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T504"/>
    <dbReference type="Ensembl" id="ENSCJPT00005011862.1">
        <property type="protein sequence ID" value="ENSCJPP00005007716.1"/>
        <property type="gene ID" value="ENSCJPG00005007038.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107313641"/>
    <dbReference type="KEGG" id="cjo:107313641"/>
    <dbReference type="CTD" id="441054"/>
    <dbReference type="GeneTree" id="ENSGT00390000010980"/>
    <dbReference type="OrthoDB" id="283553at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097731">
        <property type="term" value="C:9+0 non-motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029358">
        <property type="entry name" value="CFAP96"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31144">
        <property type="entry name" value="UPF0602 PROTEIN C4ORF47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31144:SF1">
        <property type="entry name" value="UPF0602 PROTEIN C4ORF47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15239">
        <property type="entry name" value="CFAP96-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005007716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="310" mass="34700" checksum="6DED6937A28BF591" modified="2022-01-19" version="1">MPAEGKTDMERIGLFSEMSYVSIGDNYVPRYMRPFNEAAGKNKQMLSEGSKTKSGLQDGYFEPEFKRIFSGEAYLDPVQLRRRYRLAESKKNLGKAFIPSNGDKLPCGLGSYYGTIGGPIKYFSAQLKARERYIPPGKNFYTNPGKKGTGYGYPNLTIGEQYVHEADGYEVEKILAKKALEEHRRLLKGGPFLTNIYPLEYFDINPYFNDKPLPPVKRPPLEKKIAVPFIPSSPAKKPGGMKGGTFDPYPSHSAEPYVAKKKTVILPSTEQKIFQPPPGPKSRPVTSIITQNVLRSLNTKNYKTACATSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T516</accession>
    <name>A0A8C2T516_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 4 open reading frame 54</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">C4orf54</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T516"/>
    <dbReference type="Ensembl" id="ENSCJPT00005011745.1">
        <property type="protein sequence ID" value="ENSCJPP00005007611.1"/>
        <property type="gene ID" value="ENSCJPG00005006972.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00730000111645"/>
    <dbReference type="OrthoDB" id="8945866at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052303">
        <property type="entry name" value="CEFIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027838">
        <property type="entry name" value="DUF4585"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33775">
        <property type="entry name" value="CARDIAC-ENRICHED FHL2-INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33775:SF4">
        <property type="entry name" value="CHROMOSOME 4 OPEN READING FRAME 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15232">
        <property type="entry name" value="DUF4585"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4585" evidence="2">
        <location>
            <begin position="1105"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="813"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="886"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1031"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1194"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="204"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="548"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="583"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="732"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="757"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="828"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="930"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="985"/>
            <end position="1004"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005007611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1268" mass="128729" checksum="8B69FCE00E057AB0" modified="2022-01-19" version="1">MDAAGPQPAGPEGRGPGKEEEETAAAYAEVCGSAGAESGAADGGAAVATEGPAPAGHRPEVAAPGCGSGPGSPSSSSCPSAGSATGGGGAEEATAAGGQTSSSSLGCESDEEAGEGRGAGEPPRRALGSAHYISTQEIQLSEVDHDMDFDAGLAARWDFEDDNVIYSFVDYASFGSDETPGDTPTEEDNSCYLSTTPSERTARADSAGSGSEAAGGSSGSGTGASPAGHVLLSIKAASRAIKECSAAREERHATYGAEHEGDMSLRVAAAPERAAASGQDAGRQHAKKFIAVPARLQTRCGAREAGGCSSGASSAVSELDDADKEVRNLTARAFRSLAYPYFDTLSLGSRASSASLSDHALGVNRWSTYLDLKCGALGPRGAAGGGQLCVRSGKAPSRALQFVVSKLDGEIAHVEAPPPPRGTLGVREPGRAARAGEEEASKKSKFASSLLKNVISKKMQLEHEFKMERGELTDTSSAGPGAAPPAGRDPEPGTGSGGGGRPREGGVQRQSSRLSEGGSEHGAPPPEEPGERGGGRSPAPKAATPREGSQERTAVEEGADARRSGSEAARATFLRSQHSAFRSWKEREAESKEERAPGGKAKPSPRPEPGEPAAGKATKMSRLFVPGIQHANKEKEPAGQRPASPPAAKPRLPEIKISLGPPAEPPFSIAQLLTPQLAARPPDTGLRAPRPDGSDRVPQFLVRDVREGKGKAQAPLHQVRDVRKLIKGSHGGDSADAGSDRGSVGSEQGGAEHRQPGWAEAGGKAAAAGGRALGCPPEGTVLVHRTSGRLPVATIAPNKSDPRQPSVLKIVAKSAAPWRHQAAPAPAEKGRGAEEDPREEGKAAPVQNALEKLTAAVRSMEELYSFSKREWKRKSDPLPITGSHVLSLIASQERDAGPRPPLAAEPSPKAEEPSNKGPGPTGGERLPRRAANPAAAADKVSAKAAAFESLARQRQRGPAPPRALLTLRGSAAPPAKPPADGGVRGPSAAATAALAPRAPRLPAPGGEGRAEPERGTDCEGYLALPLAAARPGPAPAAAAGGGRPAPVSFGAAPPAGGPGLPSAADASAAPQSPDAATALFPPALPPFAAAPPAPLFCFSPSVAEPLPQRRVLLDVSSGQYYLLDAPPQQPVKRRLFDPESGQYVEVPVPPPAVAPLPLPLSPLALNAGAFGAAYMLYPGLLPAAVLPAGALQRPLSHPGSEGSGAADPGSPAEPEAPYYVPGGQGPAARHGTAEAKPLVSIAAPGGGPRLVAPPSFDGTTMRLVVEHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T6W4</accession>
    <name>A0A8C2T6W4_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Protein-arginine deiminase</fullName>
            <ecNumber evidence="3 8">3.5.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">PADI1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the deimination of arginine residues of proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>L-arginyl-[protein] + H2O = L-citrullyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:18089"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:10588"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:83397"/>
            <dbReference type="EC" id="3.5.3.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the protein arginine deiminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.15" evidence="3 8"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2T6W4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005012425.1">
        <property type="protein sequence ID" value="ENSCJPP00005008146.1"/>
        <property type="gene ID" value="ENSCJPG00005007338.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153217"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004668">
        <property type="term" value="F:protein-arginine deiminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04214">
        <property type="entry name" value="PAD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1700:FF:000001">
        <property type="entry name" value="Protein-arginine deiminase type-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.75.10.10:FF:000003">
        <property type="entry name" value="Protein-arginine deiminase type-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.75.10.10">
        <property type="entry name" value="L-arginine/glycine Amidinotransferase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1700">
        <property type="entry name" value="Protein-arginine deiminase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1860">
        <property type="entry name" value="Protein-arginine deiminase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004303">
        <property type="entry name" value="PAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013530">
        <property type="entry name" value="PAD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036556">
        <property type="entry name" value="PAD_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013732">
        <property type="entry name" value="PAD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038685">
        <property type="entry name" value="PAD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013733">
        <property type="entry name" value="Prot_Arg_deaminase_cen_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10837">
        <property type="entry name" value="PEPTIDYLARGININE DEIMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10837:SF11">
        <property type="entry name" value="PROTEIN-ARGININE DEIMINASE TYPE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03068">
        <property type="entry name" value="PAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08527">
        <property type="entry name" value="PAD_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08526">
        <property type="entry name" value="PAD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001247">
        <property type="entry name" value="Protein-arginine_deiminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55909">
        <property type="entry name" value="Pentein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110083">
        <property type="entry name" value="Peptidylarginine deiminase Pad4, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein-arginine deiminase (PAD) N-terminal" evidence="11">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Protein-arginine deiminase (PAD) central" evidence="12">
        <location>
            <begin position="112"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Protein-arginine deiminase C-terminal" evidence="10">
        <location>
            <begin position="280"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="350"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="470"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="472"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR001247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001247-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005008146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="663" mass="73667" checksum="4DB1AE41FC450255" modified="2022-01-19" version="1">MSQRQVVQMSTSHASYGVCVLGTEVFLDTHRSTPKGATSFDVHATSAVTVHIIHSPVTKPMLNSRWPLDPDIEIVVTIGVTSKTVNDNKVKISYYGREENEIAVAWLYLTCVDISLDVDVSRNGRVRSKGKDKAKWTWGPDGQGAVLLVNCDKDSPGTVGTDCSQVDICTPADLQDMSVMLLRIQGPSSVFANYQLVLHVSESDADKVRVFHAVRSDSHPQYKPVLGPGMLSYTLDCVGSGENTFYVEGLAFPDAGFSGLVSISVSLLEVHHKYSPGTPIFTDTVVFRMAPWIMTPNTQQPLEVFVCSIKRGINSNEVFLEELQALLRKANCKMTICSEIESRSDRWIQDELEFGYVEAPHKSFPVVFDSPRNRGLKDFAFKKILGPDFGYVTRVPLGCDACSLDSFGNLDVSPPVTVRGKEYPLGRILIGSPLPWASGRRMSKVVRDFLYAQKVQAPVEVYSEWLSVGHVDEFLTFVPAYDRKGFRLLLASPTACFKLFQEKQRQGYGEATQLVGMVGSERRSIDDILADEGLRNDNKHVQVGCLDDFRRLLKKDSLGLSEQDIIDIPQLFILRGSRAEALFPDMVNMLVLGRHLGIPKPFGPLVAGQCCLEERVRALLQPLGLSCTFINDFFSYHVLSGDVHCGTNVRRKPLAVKWWHVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T6Z0</accession>
    <name>A0A8C2T6Z0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">TSPAN3</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Regulates the proliferation and migration of oligodendrocytes, a process essential for normal myelination and repair.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Interacts with claudin-11/CLDN11 and integrins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the tetraspanin (TM4SF) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015727948.1">
        <property type="nucleotide sequence ID" value="XM_015872462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T6Z0"/>
    <dbReference type="SMR" id="A0A8C2T6Z0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005013605.1">
        <property type="protein sequence ID" value="ENSCJPP00005009069.1"/>
        <property type="gene ID" value="ENSCJPG00005008027.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107318529"/>
    <dbReference type="KEGG" id="cjo:107318529"/>
    <dbReference type="CTD" id="10099"/>
    <dbReference type="GeneTree" id="ENSGT00940000154954"/>
    <dbReference type="OrthoDB" id="9993879at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03163">
        <property type="entry name" value="TM4SF8_like_LEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1450.10:FF:000004">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000301">
        <property type="entry name" value="Tetraspanin_animals"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018503">
        <property type="entry name" value="Tetraspanin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF48">
        <property type="entry name" value="TETRASPANIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002419">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00421">
        <property type="entry name" value="TM4_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="208"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00055382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00065266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005009069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="253" mass="28108" checksum="1FE150E26968C095" modified="2022-01-19" version="1">MGQCGITSSKTVLVFLNLIFWAAAGILCYVGAYVFITYDDYDHFFEDVYTLIPAVIIIAVGTLLFIIGLIGCCATIRESRCGLATFVIILLLVFITEVVVVVLGYIYRAKVEDEVDHSIQKVYNGYNGTNPDAASRAIDYVQRQLRCCGIHNYTDWENTVWFKQTKNNSVPLSCCKATLSNCTGSLTRPMDLYSEGCEALVVKKLQEIMMYVIWAALAFAAIQLLGMLCACIVLCRRSRDPAYELLITGGTYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T7C1</accession>
    <name>A0A8C2T7C1_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AGBL carboxypeptidase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">AGBL3</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[protein] + H2O = (L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[protein] + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:60004"/>
            <dbReference type="Rhea" id="RHEA-COMP:15519"/>
            <dbReference type="Rhea" id="RHEA-COMP:15675"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:143623"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:60005"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T7C1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005014261.1">
        <property type="protein sequence ID" value="ENSCJPP00005009559.1"/>
        <property type="gene ID" value="ENSCJPG00005008385.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160916"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050821">
        <property type="entry name" value="Cytosolic_carboxypeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040626">
        <property type="entry name" value="Pepdidase_M14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12756">
        <property type="entry name" value="CYTOSOLIC CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12756:SF23">
        <property type="entry name" value="CYTOSOLIC CARBOXYPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18027">
        <property type="entry name" value="Pepdidase_M14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M14" evidence="7">
        <location>
            <begin position="263"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005009559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="410" mass="47900" checksum="C8E9B1E7B964F362" modified="2022-01-19" version="1">MRGFFHFLTDSVYADMFPRAKELPLDLETVVPHLPELQNPCVSPPAGQFSQVYWPNQLEVISDRIEHIDWIPSSPEPLYTPTGLEMRPSYQPPDKGTVIYLGEVANTESYFMYSQMRGLCPHQVFHQEVGNTLVFEARFESGNLQKVVKVNEFEYQLTLRTDLYTSRHVQWFYFQVSNTQAGMPYRFTIVNFTKRKSLYRHGLRPLLYSEADAKKYNIGWRRTGSEIKYYRNNMNEGGRPHFSLTWTFQFPHDRDTCYFAHCYPYTYSNLQEYLTDISKDPRKSKFCKIHILCHSLAGNIVNVLTITNPPRGDEDTKRKAVILTARVHPGETNSSWIMKGILDYILGNSGKAHQLRDTFVFKVVPMLNPDGVIVGNHRCSLTGHDLNRKYKSKVRKYYPSVWYTRNMIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T816</accession>
    <name>A0A8C2T816_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Retinoic acid-induced protein 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC107312508</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T816"/>
    <dbReference type="Ensembl" id="ENSCJPT00005014473.1">
        <property type="protein sequence ID" value="ENSCJPP00005009718.1"/>
        <property type="gene ID" value="ENSCJPG00005008511.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182961"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070062">
        <property type="term" value="C:extracellular exosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
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        <property type="entry name" value="G PROTEIN COUPLED RECEPTOR, CLASS C, GROUP 5"/>
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    </dbReference>
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        </location>
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        </location>
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        <source>
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        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005009718.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="347" mass="39317" checksum="B897992E1A066826" modified="2022-01-19" version="1">MTTQPPRGCGSIHADYFLLCDMDQAWGIVLESLAAAGVLVTVFLICSLFFLICKVQDNSKRHMISIYFFFLLGTLGIFGITFAFIIRSNERIRPTRFFLFGVLFALCFSCLLIHASNLIRLVRGKKSFSWPVLLLLIVSFALVQVVINIEYLVTMVVKDRDAFLNMLPEEANKDFVMLLIYVLFLMALTFLVSMFTFCGPYKSWKRHGAHIFVTVLFSIAIWVVWITMLTRGNRSLEKTTWDDPVVAIALVSNGWIFLIMYIIPEICFLTAPIKLGDYPPENDFCQPTFIKQAIGVDNHAYAQDEIAQVKTASLPFQTLDAKNDFSIPRAKAHPSPYHDYTGGKGPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T904</accession>
    <name>A0A8C2T904_COTJA</name>
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        <submittedName>
            <fullName evidence="7">Divergent protein kinase domain 2B</fullName>
        </submittedName>
    </protein>
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        <name evidence="7" type="primary">DIPK2B</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    </dbReference>
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        <property type="gene ID" value="ENSCJPG00005008983.1"/>
    </dbReference>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <source>
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    </evidence>
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        </source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="430" mass="49055" checksum="FAFD280C063E798B" modified="2022-01-19" version="1">MGRWMCCLCSRVADWLMLLLVLARSSNPSTAATASPSVPHVRPSYSFGRTFLGLDKCNACIGTSICKKFFKEEIRFDTWLSSHLKLPPSYLLSYLGNYTDDAQSWRMVDITRLTTKYQHDRADQRICTSLLKTKTCSLEQALRRTHRFQKWLRAKRLTPDLVQGLSSPMLRCPSQRLLDRIVRRYAEVPDAGSIYMDHLTDQDKLRLLYTLSVNSHPILLQIFPDVEGWPFPRYLGSCGRLVVSASTRPLRDFFRAAPEVAADLALQLLAVLRSMGTNDLNYFFYFTRVDVGTFGVFSNGHLFIRDASTLGIIDKEEGSQPFDGQQEYKDIFSCLTVDCQSAFVSCNSIREKQSLVMVCQELLPKLLKGKFLPPVQEKIDSFLQHCAEGLADDQDVNEAMAKLAQLLKPLRSCDSRFAYRYPDCKYSDKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T9S5</accession>
    <name>A0A8C2T9S5_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Small integral membrane protein 45</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">SMIM45</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
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        <lineage>
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            <taxon>Coelurosauria</taxon>
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            <taxon>Neognathae</taxon>
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            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="gene ID" value="ENSCJPG00005009090.1"/>
    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042551">
        <property type="term" value="P:neuron maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005010438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="68" mass="8093" checksum="95CC1E8393002814" modified="2022-01-19" version="1">MPHFLDWFVPVYLMISILILVGFGACIYYFEPGLHEAHKWRTQRPIMERDLRKTLMIRDNLAFGVPEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TAK8</accession>
    <name>A0A8C2TAK8_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ezrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">EZR</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015713820.1">
        <property type="nucleotide sequence ID" value="XM_015858334.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TAK8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005014714.1">
        <property type="protein sequence ID" value="ENSCJPP00005009870.1"/>
        <property type="gene ID" value="ENSCJPG00005008646.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107311637"/>
    <dbReference type="KEGG" id="cjo:107311637"/>
    <dbReference type="CTD" id="7430"/>
    <dbReference type="GeneTree" id="ENSGT01020000230354"/>
    <dbReference type="OrthoDB" id="6018897at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001650">
        <property type="term" value="C:fibrillar center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030175">
        <property type="term" value="C:filopodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001772">
        <property type="term" value="C:immunological synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005902">
        <property type="term" value="C:microvillus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TB43</accession>
    <name>A0A8C2TB43_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DENN domain containing 2D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">DENND2D</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TB43"/>
    <dbReference type="Ensembl" id="ENSCJPT00005015405.1">
        <property type="protein sequence ID" value="ENSCJPP00005010394.1"/>
        <property type="gene ID" value="ENSCJPG00005009056.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182931"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11500:FF:000004">
        <property type="entry name" value="DENN domain-containing protein 2C isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005112">
        <property type="entry name" value="dDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051942">
        <property type="entry name" value="DENN_domain_containing_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005113">
        <property type="entry name" value="uDENN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15288">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15288:SF2">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03455">
        <property type="entry name" value="dDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03456">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00801">
        <property type="entry name" value="dDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00799">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00800">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="3">
        <location>
            <begin position="115"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="18"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005010394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="527" mass="59317" checksum="E3996C7DDE370375" modified="2022-01-19" version="1">MLLALPISRCAPALPTAPPLFSSPLRPVPSLHPRESESATGGSGAPRSAAPGPLHVGATMASSISSLFRRSLRRPGRREGKQEAPAADGIPSHMPLGKAGERSSILYSAGQFFFEYLVVVSLKKMPDGRYEPKIAYQFPKRENLLKGQKEEEERLLQAIPLFCFPDGNNWEPVTTFPSETFSFVLTNVDGSRKIGYCRRLLPSGRGVRLPEVFCIISCLGCFGLFSKILDEVEKRRQISMAVIYPFMQGLRESPFPAPGKTVTIKSFIPESGTELIELTRPVDAHLEHVEFPALLQRLSPILILHIFASAVLERRLIFLAEELSVLSQCIHAVAALLYPFTWAHTYIPVVPECLLDTVCCPTPFMVGIQMRHLERVLEQPMEEALIVDLCEGKIIRAVGDEEDILPMKLQNEMLASLNRHNNNNNVHTSEQLNALVSEAFVQFFVRLVGHYSSHIKWSKNGLGTFQERAFCKAITSKTNRRFVKKFVKTNMFSLFIEDAEKSRIPQEAYFQQKITEYHQQKKHRRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TC29</accession>
    <name>A0A8C2TC29_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Heat shock 70 kDa protein 4L</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Heat shock 70-related protein APG-1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Osmotic stress protein 94</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">HSPA4L</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Possesses chaperone activity in vitro where it inhibits aggregation of citrate synthase.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TC29"/>
    <dbReference type="Ensembl" id="ENSCJPT00005013929.1">
        <property type="protein sequence ID" value="ENSCJPP00005009315.1"/>
        <property type="gene ID" value="ENSCJPG00005006064.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158736"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000004">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000495">
        <property type="entry name" value="Heat shock protein 4b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000767">
        <property type="entry name" value="Heat shock protein 70 (HSP70)-4, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000017">
        <property type="entry name" value="Heat shock protein family A (Hsp70) member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000030">
        <property type="entry name" value="Heat shock protein family A (Hsp70) member 4 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 4L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="550"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="598"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="829"/>
            <end position="882"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00054497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00069528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00077186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00082032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005009315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="882" mass="99025" checksum="D8E54886C5BA459F" modified="2022-01-19" version="1">IHQIAEAGAGARRTARRAAQRACAEARRRRLVAGAPQWHRGGGGRSQQRSAAVAGRRGAPSAVMSVVGIDLGFLNCYIGVARSGAPPSLGPRLPFSPEYLSQIVTNVKNTLHGFKKLHGRAFEDPYIQAERAKLPYELQKMPNGSVGVKVRYLDEERLFAVEQITGMLLAKLKETSESALKKPVADCVISVPSFFTDTERRSVMAAAQIAGLNCLKLMNETTAVALAYGIYKQDLPALEEKPRNVVFVDMGHSAYQVSICAFNKGKLKVLATTFDPFLGGRNFDEALVDYFSEEFRTKYKLNVKENPRALLRLYQECEKLKKLMSANASDLPLNIECFMNDLDVSSKMNRAQFEQLCAALLSRVEPPLRAAMEQAKLQREDIYGIEIVGGATRIPAVKEQISNFFCKEISTTLNADEAVARGCALQCAILSPAFKVREFSITDVVPYSITLRWKSSYEEGTGECEVFSKNHAAPFSKVITFHKKEPFDLEAFYTHPHEVPYPDSRIGRFTIQNVGPQHDGDNSKVKVKVRVNIHGLFSVANASIIEKQNIEGDHSDAPMDTESSIKNQGREDELDKMQIDQDEGVQKSQAEHSLQLQTLQASSGDKQDHPSLPRAKTKVKSIDLPIQASLYRQLGQDLINCYIENEGKMIMQDKLEKERNDAKNAVEEYVYDFRDKLCGVFEKFITEEDTNKLTLMLEDTENWLYEDGEDQPKQVYMDKLQELRKFGQPIQERYMEHEERPKVLNELGKKIQLLMKAVEAYKNKDEKYDHLDPAEMEKVEKYISEAMNWLNTKMNAQNKLSLTQDPIVKVAEIMSKSKELDSFCNPIIYKPKPKIEPPNDGQSKANGEHNGPVNGQSSTETGPDPAKDNSQQTKPSGEMEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TCU1</accession>
    <name>A0A8C2TCU1_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Leucine rich pentatricopeptide repeat containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LRPPRC</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TCU1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005017231.1">
        <property type="protein sequence ID" value="ENSCJPP00005011827.1"/>
        <property type="gene ID" value="ENSCJPG00005010045.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00960000186682"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097222">
        <property type="term" value="P:mitochondrial mRNA polyadenylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000957">
        <property type="term" value="P:mitochondrial RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905638">
        <property type="term" value="P:negative regulation of mitochondrial mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070129">
        <property type="term" value="P:regulation of mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033490">
        <property type="entry name" value="LRP130"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057027">
        <property type="entry name" value="TPR_mt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46669">
        <property type="entry name" value="LEUCINE-RICH PPR MOTIF-CONTAINING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46669:SF1">
        <property type="entry name" value="LEUCINE-RICH PPR MOTIF-CONTAINING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23276">
        <property type="entry name" value="TPR_24"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="496"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="523"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="190"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Pentatricopeptide repeat-containing protein-mitochondrial" evidence="4">
        <location>
            <begin position="224"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="225"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Pentatricopeptide repeat-containing protein-mitochondrial" evidence="4">
        <location>
            <begin position="403"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="694"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005011827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1259" mass="143185" checksum="F7D90DC0CE368DF4" modified="2022-01-19" version="1">AGSLHHVTQVGIQAGLEYPQRRRLHHLPGQPVPVLRHPHCKEVLLHIPRFLTVVPQREGNIKEEPVSEIQTRRALQFDWALNKLDNSVRKTGRIPKSLLLKVFQETCRDGCPGSNQTLLLLRSCGALLPEVLSSERTELAHMIWDKMKELGAVYDTSHYNALLKVYLQNEHKFSPTEFLARMEEANVQPNRVTYQRLIAAYCNEGDIEGASKILGFMKSKDLPITEAVFSSLVKGHARAGDIKSAENILSVMRMAGVEPGPDTYLSLLNVYAEKGDVDNIKKTLDEVDKTEGYLMDRVLMQVIFSLAKAGYPQYIEDIKERIRFEKELIPDMMNLCLSLVTHGFEDISFHILKTYNHSSPENVDQGSFFLQHCVNRNMPMSKLKQFCNELKEAKMHSAPLVFILRCALETNRSDLAIDVMKAMKEEGLPIRPHYSWPLLVGFQKEKNLKGVFEVLKVMHELGVELNAETYTDYVFKNFADIETACAQMKVSLRLEFMKAIIAWYVSLYVFCTCTALNVNLFSVILVECFLLFFSTEAVGYFLYHLIDSMSDSEVQAKEERLRQYFHQLKKMNIVIPATYCSGICRLLDSSQVPELIKVCASVSAKSDVSALEKKLEKRKAENQPITDVLKQLIYALCEEENMQKALEVKAKYEPDMVVGGYAALINLCCRHDNVEEAMNLKEKVFPRSSPVALDSGKYIALVEVLAKHGRLEDAINVLTEMKEKDVPISDRAVASFFRLLNAAAIRGEVETVNRLHETIVNLGLAETAALYSPLITVHLEKDDMPAVLEALMDCYKKHGKILQLHNIYCRLIEKGDTELLRKVSDFISSEYGDMMALYDLFFAFLQTGKYKEARKVIETPGLRAHSGRLQWFAKRCISGNQMETLENLVELTQNVFECDRDEMYYYLLQLYNNSDWRKAEAVWTKIQEENVVPREKTLRLLADIFEKNGQVVPFEVPKAYDAFLKSQEKSSYQYRTYDTLIKALLSLDCIEEAMNVKHIAETHIKGFTLNSAASSLLIISQVRRDYLKDAVAAFQGMLDSGLLPSRPAVIALTQALAMNGDLRSLKALENMVESITKSIGLSSSLISNAIALAHTKNLQKCLFNQRISLFPFCFPNIFYHFVVGVMAERLANQFGIYRPVTDLFLQYVSADRVDDARSLLQRCGGLVEEKRAFVNFMVKSASKLVLIYFFFPSELDEDVASVKAVYEKTKEKNIQLPELSLKSLAVFLKKAGEPVPFTEPPESFKFYAEEWRKRRLEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TCZ0</accession>
    <name>A0A8C2TCZ0_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fibronectin type III domain containing 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FNDC10</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TCZ0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005017245.1">
        <property type="protein sequence ID" value="ENSCJPP00005011841.1"/>
        <property type="gene ID" value="ENSCJPG00005010121.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00550000076432"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034446">
        <property type="entry name" value="Fndc10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39233">
        <property type="entry name" value="FIBRONECTIN TYPE III DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39233:SF1">
        <property type="entry name" value="FIBRONECTIN TYPE III DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17742">
        <property type="entry name" value="Fndc10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034666457" evidence="2">
        <location>
            <begin position="21"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005011841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="214" mass="23121" checksum="52BEE4801BBF44DB" modified="2022-01-19" version="1">MPRLLPALLALLCFGPPTPAPSAALTEAASEPEEPWCPYKVRPEGSAGGRLCFRRPALGFQCSARSCRAHRSPGGALVANVLLNGSVLLQWATPRPGNGLRGFTLNCSWDGTYTRFPCDSVELGAACRDYLLPEAHGTVRYQLCLQPRYNAPRPAPPAHCVEFRVEPAAMRDIVVAMTAVGGSICVMLVFICLLVAYITENLMTLIIPALSRQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TD49</accession>
    <name>A0A8C2TD49_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-alpha-acetyltransferase 35, NatC auxiliary subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Protein MAK10 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">NAA35</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAK10 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015704767.1">
        <property type="nucleotide sequence ID" value="XM_015849281.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015704769.1">
        <property type="nucleotide sequence ID" value="XM_015849283.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015704770.1">
        <property type="nucleotide sequence ID" value="XM_015849284.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015704771.1">
        <property type="nucleotide sequence ID" value="XM_015849285.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032297448.1">
        <property type="nucleotide sequence ID" value="XM_032441557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TD49"/>
    <dbReference type="Ensembl" id="ENSCJPT00005016020.1">
        <property type="protein sequence ID" value="ENSCJPP00005010902.1"/>
        <property type="gene ID" value="ENSCJPG00005009427.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107306263"/>
    <dbReference type="KEGG" id="cjo:107306263"/>
    <dbReference type="CTD" id="60560"/>
    <dbReference type="GeneTree" id="ENSGT00390000002445"/>
    <dbReference type="OrthoDB" id="269405at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome Z"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048659">
        <property type="term" value="P:smooth muscle cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057983">
        <property type="entry name" value="NAA35-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007244">
        <property type="entry name" value="Naa35_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057982">
        <property type="entry name" value="TPR_NAA35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21373">
        <property type="entry name" value="GLUCOSE REPRESSIBLE PROTEIN MAK10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21373:SF0">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 35, NATC AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04112">
        <property type="entry name" value="Mak10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25789">
        <property type="entry name" value="TPR_NAA35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAA35-like N-terminal" evidence="7">
        <location>
            <begin position="46"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="NAA35-like N-terminal" evidence="7">
        <location>
            <begin position="146"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="NAA35-like TPR repeats" evidence="8">
        <location>
            <begin position="338"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="548"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="558"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005010902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="725" mass="83527" checksum="52EBA12FC7D1ACB0" modified="2022-01-19" version="1">MVMKASVEDDDSGWELGMPDKMEKGNTDWVDITRDFEEACRELKLGELLHDKLFGLFEAMSAIEMMDPKMDAGMIGNQVNRKVLNFEQAIKDGTIKIKDLTSPELIGIMDTCFCCLITWLEGHSLAQTVFTCLYIHNPDFIEDPAMKAFALGILKICDIAREKVNKAAVFEEEDFQSMTYGFKMANSVTDLRVTGMLKDVEDDMQRRVKSTRSRQGEERDPEVELEHQQCLAVFSRVKFTRVLLTVLIAFTKKETSAVAEAQKLMTQAADLLSAIHNSLHHGIQAQNDTTKGDHPIMMGFEPLVNQRLLPPTFPRYAKIIKREEMVNYFSKLIDRIKTVCEVVNLTNLHCILDFFCEFSEQSPCVLSRSLLQTTFLVDNKKVFGAHLMQDMVKDALRSFVSPPVLSPKCCLYNSHQAKDYIDSFVTHCVRPFCSLIQIHGHNRARQRDKLGHILEEFATLQDEAEKVDAALHSMLLKQEPQRQHLACLGTWVLYHNLRIMIQYLLSGFELELYSMHEYYYIYWYLSEFLYAWLMSTLSRADSSQMAEERIMEEQQKGRSSKKTKKKKKVRPLSREITMSQAYQNMCAGMYKTMIAFDMDGKVRKPKFELDSEQVRYEHRFAPFNSVITPPPVHYLQFKEMSDLNKYSPPPQSADLYMAASKHFQQAKMILENIPNPDHEVNRILKVAKPNIVVMKLLAGGHKKDTKVPPEFDFSPHKYFPVVKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TF50</accession>
    <name>A0A8C2TF50_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">1-aminocyclopropane-1-carboxylate synthase homolog (inactive)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ACCS</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015720038.1">
        <property type="nucleotide sequence ID" value="XM_015864552.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TF50"/>
    <dbReference type="Ensembl" id="ENSCJPT00005018388.1">
        <property type="protein sequence ID" value="ENSCJPP00005012720.1"/>
        <property type="gene ID" value="ENSCJPG00005010821.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107314834"/>
    <dbReference type="KEGG" id="cjo:107314834"/>
    <dbReference type="CTD" id="84680"/>
    <dbReference type="GeneTree" id="ENSGT00940000164760"/>
    <dbReference type="OrthoDB" id="691673at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000032">
        <property type="entry name" value="Zinc finger and SCAN domain-containing 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050478">
        <property type="entry name" value="Ethylene_sulfur-biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044822">
        <property type="entry name" value="Myb_DNA-bind_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795:SF17">
        <property type="entry name" value="1-AMINOCYCLOPROPANE-1-CARBOXYLATE SYNTHASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795">
        <property type="entry name" value="BIFUNCTIONAL ASPARTATE AMINOTRANSFERASE AND GLUTAMATE/ASPARTATE-PREPHENATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13837">
        <property type="entry name" value="Myb_DNA-bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00753">
        <property type="entry name" value="ACCSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like DNA-binding" evidence="5">
        <location>
            <begin position="12"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="4">
        <location>
            <begin position="417"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="787"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005012720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="874" mass="99693" checksum="880E4B29EBC83A69" modified="2022-01-19" version="1">MDFRGKKYERGSNWSDPEVVELLQLWADESVQLELESCLRNQHVFNRIAEVLREKGIHRTGDQCREKIKKMKLEYRRIKDNSKAPRGGRTWKFYDVMDRVLNSRPALAYGPMGGGVMATQVLPGGVVEGYHHQFTAPALPFGHSQHPELMEIKCEEVNSDEHCLTPEPPAAVSYQQGCPEEHEMERAFLERAQNDSPISRVEIPIETSVSPSGFSEPSMANSSRMQNAVPRPGFSALHRLRKKRKGQRVKDPLDDLLLKTLTSQRAMEERFLQMEERRFQRDLDVEERRMQLEQRRFELEREHEFRMFNVFAQMLSILKQSNGSASPSLAMPRGLDFSQMLSELMGRVGDNQRGPRARGLAGSRGNMCGFCPPEGFRCSPYLSARGNVANVFRGSDEEGYKAYHADKYDEDTNPNGIINFGTSENKLCCDLMSKRLKEQLTQTDMNLMEPLLLQYPDWKGHMFLREEVARFLTYYCKAPAPLKAENVIILNGCGSLFSALATVLCDPGEAVLIATPFYGGITQSVFLYGNVKLVYAYLDSKITGTSTRPFQLTVDKLEKALQDALAEGVTVRALILLNPQNPLGDIYSLSELRDYLEFAKRHELHVIVDEIYMLSVFDESATFHSVLGMDRLPDPQRTHVMWGITKDFAVSGIRFGTLYTENQDVANAVASLCYFHGVCGPVQHKVAQLLRDREWINQVYLRANHARLKAAHTYVTDELKTLGVPFLNRNAGFFVWIDFRKYLRTGTFEEEMLLWRRFLDNKVLLSCGKAFECSEPGWFRIIFADKTNRLQLGMQRIRKVLEEQEREILSEEKQQPCQSDQDGKADSTDEVIFVSRHQESSCAGSSNLSDLIGLLQQQMRSSDWLQKNAAEQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TFT5</accession>
    <name>A0A8C2TFT5_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Desmoglein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">DSG2</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Desmosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TFT5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005016780.1">
        <property type="protein sequence ID" value="ENSCJPP00005011492.1"/>
        <property type="gene ID" value="ENSCJPG00005009873.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107310125"/>
    <dbReference type="KEGG" id="cjo:107310125"/>
    <dbReference type="GeneTree" id="ENSGT01030000234624"/>
    <dbReference type="OrthoDB" id="8961010at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030057">
        <property type="term" value="C:desmosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014704">
        <property type="term" value="C:intercalated disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0086073">
        <property type="term" value="P:bundle of His cell-Purkinje myocyte adhesion involved in cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002934">
        <property type="term" value="P:desmosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060231">
        <property type="term" value="P:mesenchymal to epithelial transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045602">
        <property type="term" value="P:negative regulation of endothelial cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010719">
        <property type="term" value="P:negative regulation of epithelial to mesenchymal transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106015">
        <property type="term" value="P:negative regulation of inflammatory response to wounding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045785">
        <property type="term" value="P:positive regulation of cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0150107">
        <property type="term" value="P:positive regulation of protein localization to cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903672">
        <property type="term" value="P:positive regulation of sprouting angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902459">
        <property type="term" value="P:positive regulation of stem cell population maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003165">
        <property type="term" value="P:Purkinje myocyte development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0086091">
        <property type="term" value="P:regulation of heart rate by cardiac conduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098911">
        <property type="term" value="P:regulation of ventricular cardiac muscle cell action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072089">
        <property type="term" value="P:stem cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000011">
        <property type="entry name" value="Cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000031">
        <property type="entry name" value="Cadherin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000068">
        <property type="entry name" value="Desmoglein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000083">
        <property type="entry name" value="Desmoglein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.900.10:FF:000003">
        <property type="entry name" value="Desmoglein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000074">
        <property type="entry name" value="Desmoglein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.900.10">
        <property type="entry name" value="TCF3-CBD (Catenin binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050971">
        <property type="entry name" value="Cadherin-domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027397">
        <property type="entry name" value="Catenin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009122">
        <property type="entry name" value="Desmosomal_cadherin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24025">
        <property type="entry name" value="DESMOGLEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24025:SF1">
        <property type="entry name" value="DESMOGLEIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01818">
        <property type="entry name" value="DESMOCADHERN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01819">
        <property type="entry name" value="DESMOGLEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="10" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="11" id="KW-0965">Cell junction</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 18" id="KW-0732">Signal</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034827715" evidence="18">
        <location>
            <begin position="27"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="607"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="19">
        <location>
            <begin position="73"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="19">
        <location>
            <begin position="162"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="19">
        <location>
            <begin position="272"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="19">
        <location>
            <begin position="388"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="879"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1076"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1087"/>
            <end position="1106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005011492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1106" mass="118365" checksum="AE91A58D466DB45D" modified="2022-01-19" version="1">MSRGSAAAVRLLALLVLLICLSCGNGLHWKIYNRSGRHGASSHPNSPVRQKREWTVPPAFIREEEDNSYRNPIARIHSDLEDTGIVVTYTISGQGVTEPPYGLFVINGKTGDLNITGRVDREKTPRLLLRGHALDKTGAKLEEPIDLPIRVLDINDNPPVFSHEVFVGSIEELSETGTIVMRLNATDADEPNNLNSKIAFRIISQSPSSAFSMNKDTGEVRVAAINLDRETQSSYSLVVEGKDRDGAADGNSATCSLEIKILDVNDNLPVLESSAFEGSVEENRANVEIMRIKVFDKDEEFSDNWLANFSFVSGNEGGYFRIVTDTKTNEGVLTLVKALNYEEMRSLNLGFVVTNKAEFHKSIKNSYKAQTIPIKIHVIDVREGPVFPGGTKIIEASESVRVSQVIGQYQALDEDTGKAAVNIKYIKGRDPANWITINSKTGEIQLAKNLDYESAYVVNGTYTFTMLGVTTDVPAKTVTGTVVVQVQDENDNCPIIENPVRTVCSDATFVDVTANDIDSYPNSAPYSFSVIDEPEGTARNWIIASRNATSVRLVPQNLKAGSTEVPLQIQDFQGFSCAQPQSLQLYVCTCTADGGCKDRITGSGSAFLGPGAVALIILAFLLLLLIPLLLLLCPCGSGAKKGFAAIPDCSEEMLRKWNSEGAAPEEKSMQSVMLPTALGNLKGAAGGAGAVTAAAAAAGMSAEEAAAGASSSASNIRGQSTITREGWEEQRHLLSSTDYHTRSMTTGRAEGMKAGEENMVVTGGGVAMGSAGAMNEEFLRDYFTDKAVTFAEEDEAQAARDCLLVYSQGESGSPHGSIGCCSFIEGDLDDRFLDDLGDKFKTLAEICIGRRIDMKDSSSKNESNFGVNEQKAFSSKQASASGGYFSPSPSAQAGGAVGSETVSQEVIMETTSSSQSGQHDVQTLTTPYTETNVTVTETSYSAGGPTRSPAGFLDPQFKENIVVTERVLAPASSLRGMVEIPSMPSGNNMVVTERMVTSEGPGLGAIAVQDLPDSKYVVVRERETVLVPSTEQGSLSFPTLSEEQSMVVNENNLTGSAGPGRAEQVLITDSLLSQAGSAMEGAPPASSMLSKSSRVTKYSTVQYSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TFW2</accession>
    <name>A0A8C2TFW2_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Proteolipid protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">PLP1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the myelin proteolipid protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TFW2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005017936.1">
        <property type="protein sequence ID" value="ENSCJPP00005012375.1"/>
        <property type="gene ID" value="ENSCJPG00005010517.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000006915"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043209">
        <property type="term" value="C:myelin sheath"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019911">
        <property type="term" value="F:structural constituent of myelin sheath"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061564">
        <property type="term" value="P:axon development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022010">
        <property type="term" value="P:central nervous system myelination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001614">
        <property type="entry name" value="Myelin_PLP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018237">
        <property type="entry name" value="Myelin_PLP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11683">
        <property type="entry name" value="MYELIN PROTEOLIPID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11683:SF11">
        <property type="entry name" value="MYELIN PROTEOLIPID PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01275">
        <property type="entry name" value="Myelin_PLP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00214">
        <property type="entry name" value="MYELINPLP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00002">
        <property type="entry name" value="PLP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00575">
        <property type="entry name" value="MYELIN_PLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="141"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005012375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="299" mass="32534" checksum="0B6383F22CBACCE0" modified="2022-01-19" version="1">MGDGHPKELTPSASPSLDVSPSLEDPMEDSLWGLCLLECCARCLIGAPFASLVATGLCFFGVALFCGCGHEALTGTEQLIETYFSKNYQDYDIHAFQYVIYGTASFFFLYGALLLAEGFYTTGAVRQIFGDYRTTICGKGLSATFVGITYVLTIVWLLVFACSAVPVYIYFNTWTTCQSIANPTKTTASIGTLCADARMYGEHCTSMRDLWELNPPLPLQFQMTFHLFIAAFVGAAATLVSLVSRCSRCPAVLLHLARRWGQRTMEVVGTEVAEPELVSFSNNKEVVGEVATGGDLEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TG32</accession>
    <name>A0A8C2TG32_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Visinin-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">VSNL1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Regulates (in vitro) the inhibition of rhodopsin phosphorylation in a calcium-dependent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the recoverin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TG32"/>
    <dbReference type="Ensembl" id="ENSCJPT00005018946.1">
        <property type="protein sequence ID" value="ENSCJPP00005013141.1"/>
        <property type="gene ID" value="ENSCJPG00005011115.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156513"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046676">
        <property type="term" value="P:negative regulation of insulin secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045921">
        <property type="term" value="P:positive regulation of exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035774">
        <property type="term" value="P:positive regulation of insulin secretion involved in cellular response to glucose stimulus"/>
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        <property type="project" value="Ensembl"/>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="Visinin-like protein 1"/>
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        <property type="entry name" value="EF-hand"/>
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        <property type="entry name" value="EF-hand-dom_pair"/>
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        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
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        <property type="entry name" value="EF_hand_dom"/>
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        <property type="entry name" value="Recoverin"/>
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    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF101">
        <property type="entry name" value="VISININ-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="EF-hand_7"/>
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    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
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    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
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    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
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    </dbReference>
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        <property type="entry name" value="EF_HAND_1"/>
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    </dbReference>
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        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0519">Myristate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="68"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="104"/>
            <end position="139"/>
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    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="154"/>
            <end position="189"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006049"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00018066"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
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    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005013141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="199" mass="23174" checksum="0507AC6E7F1DC030" modified="2022-01-19" version="1">MDHYPQCRMGKQNSKLAPEVMEDLVKSTEFNEHELKQWYKGFLKDCPSGRLNLEEFQQLYVKFFPYGDASKFAQHAFRTFDKNGDGTIDFREFICALSITSRGSFEQKLNWAFNMYDLDGDGKITRVEMLEIIEAIYKMVGTVIMMKMNEDGLTPEQRVDKIFSKMDKNKDDQITLDEFKEAAKSDPSIVLLLQCDIQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2THC6</accession>
    <name>A0A8C2THC6_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">AARS1</name>
        <name evidence="15" type="synonym">AARS</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>tRNA(Ala) + L-alanine + ATP = L-alanyl-tRNA(Ala) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Monomer. Interacts with ANKRD16; the interaction is direct.</text>
    </comment>
    <comment type="domain">
        <text evidence="15">Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2THC6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005019683.1">
        <property type="protein sequence ID" value="ENSCJPP00005013733.1"/>
        <property type="gene ID" value="ENSCJPG00005011326.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157335"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141207">
        <property type="term" value="F:peptide lactyltransferase (ATP-dependent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030330">
        <property type="term" value="P:DNA damage response, signal transduction by p53 class mediator"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035329">
        <property type="term" value="P:hippo signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901797">
        <property type="term" value="P:negative regulation of signal transduction by p53 class mediator"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035332">
        <property type="term" value="P:positive regulation of hippo signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00673">
        <property type="entry name" value="AlaRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.130:FF:000002">
        <property type="entry name" value="alanine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000011">
        <property type="entry name" value="Alanine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000004">
        <property type="entry name" value="Alanine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00036_B">
        <property type="entry name" value="Ala_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050058">
        <property type="entry name" value="Ala-tRNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023033">
        <property type="entry name" value="Ala_tRNA_ligase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00344">
        <property type="entry name" value="alaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777:SF36">
        <property type="entry name" value="ALANINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777">
        <property type="entry name" value="ALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 15" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="10 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 15" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 15" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="9 15" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alanyl-transfer RNA synthetases family profile" evidence="17">
        <location>
            <begin position="85"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="931"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="690"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="694"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="806"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="810"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005013733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1004" mass="109471" checksum="7303C9EC23E600A8" modified="2022-01-19" version="1">MAAPCPASRSPRHVTPAFRHCISRRAARPSAGIGLVGGASAERRLTQPISGRIPALRALRRPGRVCAAWGGGARRARSSEMESTLTARQIRQRFIDFFKENQHTYVHSSSTIPLDDPTLLFANAGMNQFKPIFLNTIDPSHPLAKLSRATNTQKCIRAGGKHNDLDDVGKDVYHHTFFEMLGSWSFGDYFKELACKLALDLLTKEFGIPAERLYVTYFGGNENAGLQPDLECKQIWLDLGLPEGRILPGNMKDNFWEMGDTGPCGPCSEIHYDRIGDRDASHLVNQDDPNVLEIWNLVFIQFNREADGSLKPLPKKSIDTGMGLERLVSVLQNKMSNYDTDLFLPYFEAIQKGTGARPYMGQVGAEDADGIDMAYRVLADHARTITLALSDGGRPDNTGRGYVLRRILRRAVRYSHEKLNAPKGFFATLVDVVVQSLGDAFPELKKDPDMVKDIINEEEDQFLKTLSRGRRILDRKIQSMGDSKTIPGEAEASTCSLLGCFPKSPLGNTKAQDQSCHPPVAVWVFLSFVFCHWQLKSQGKGAGGEDLLMLDIYAIEELRARGLEVTDDSPKYGYTSDPSGTYDFGSLVATVKAIRREKKFVEEVSTGQECGIVLDRTCFYAEQGGQIYDQGYMVKEDDSKEDKTEFTVKNVQVRGGYVLHIGTLYGSLKVGDQVHLSIDETRRRPVMSNHTATHILNFALRSVLGEADQRGSLVAPDRLRFDFTAKGALSTKEIKELSPASFSFALQTVYAKDCPLAAAKAIQGLRAVFDETYPDPVRVVSIGIPVEELLADPSGPAGSITSIEFCGGTHLQNSGHAGPFVIVSEEAIAKGIRRIVAVTGAEARKVRGGRGCSLLEGPWQVLFVRESLAGVWLWAVTACIGFAASLGVIEPHAQCCCLPGTPLGDGLVPYQDGLVAPPVCCDSNCVPPGPQEGGEPQEIAVSSGCQGEGADSSQQGRAEGDHGPQRGEGGSSAGTWRWVLLMKPKLIPASLSPPLGPLWLLSWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TJ11</accession>
    <name>A0A8C2TJ11_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="25">Matrix metallopeptidase 15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">MMP15</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="18">Can bind about 5 Ca(2+) ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="18">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M10A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015729170.1">
        <property type="nucleotide sequence ID" value="XM_015873684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TJ11"/>
    <dbReference type="Ensembl" id="ENSCJPT00005020816.1">
        <property type="protein sequence ID" value="ENSCJPP00005014651.1"/>
        <property type="gene ID" value="ENSCJPG00005012205.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107319098"/>
    <dbReference type="KEGG" id="cjo:107319098"/>
    <dbReference type="CTD" id="4324"/>
    <dbReference type="GeneTree" id="ENSGT00940000156939"/>
    <dbReference type="OrthoDB" id="406838at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030574">
        <property type="term" value="P:collagen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035987">
        <property type="term" value="P:endodermal cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00094">
        <property type="entry name" value="HX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04278">
        <property type="entry name" value="ZnMc_MMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000005">
        <property type="entry name" value="Matrix metallopeptidase 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.110.10.10:FF:000001">
        <property type="entry name" value="Matrix metallopeptidase 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.110.10.10">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000585">
        <property type="entry name" value="Hemopexin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036375">
        <property type="entry name" value="Hemopexin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018487">
        <property type="entry name" value="Hemopexin-like_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018486">
        <property type="entry name" value="Hemopexin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033739">
        <property type="entry name" value="M10A_MMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001818">
        <property type="entry name" value="Pept_M10_metallopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021190">
        <property type="entry name" value="Pept_M10A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021805">
        <property type="entry name" value="Pept_M10A_metallopeptidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021158">
        <property type="entry name" value="Pept_M10A_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201">
        <property type="entry name" value="MATRIX METALLOPROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201:SF25">
        <property type="entry name" value="MATRIX METALLOPROTEINASE-15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11857">
        <property type="entry name" value="DUF3377"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00045">
        <property type="entry name" value="Hemopexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00413">
        <property type="entry name" value="Peptidase_M10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00138">
        <property type="entry name" value="MATRIXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00120">
        <property type="entry name" value="HX"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50923">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="PGBD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00546">
        <property type="entry name" value="CYSTEINE_SWITCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00024">
        <property type="entry name" value="HEMOPEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51642">
        <property type="entry name" value="HEMOPEXIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 18" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 23" id="KW-0732">Signal</keyword>
    <keyword evidence="5 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10 18" id="KW-0862">Zinc</keyword>
    <keyword evidence="15" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034372527" evidence="23">
        <location>
            <begin position="31"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="601"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase metallopeptidase" evidence="24">
        <location>
            <begin position="114"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="20">
        <location>
            <begin position="336"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="20">
        <location>
            <begin position="385"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="20">
        <location>
            <begin position="432"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="20">
        <location>
            <begin position="481"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="282"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="536"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="318"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="560"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="active site" evidence="17">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <feature type="binding site" description="in inhibited form" evidence="18">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="389"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="391"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>5</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="438"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>5</label>
        </ligand>
    </feature>
    <feature type="modified residue" description="Phosphotyrosine; by PKDCC" evidence="19">
        <location>
            <position position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="SMART" id="SM00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005014651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="644" mass="73271" checksum="12DDD93813FC4D3C" modified="2022-01-19" version="1">MAGGGARREGAPCRAGGTLVLLALLGAAGAELNAEAWLRLYGYLPPGSRQMSTMRSAQILSSALSEMQKFYGIPVTGVLDEETKTWMRRPRCGVPDQFGVRMKSNMRRKRYALTGRRWSQSHLTFSIQNYTEKLGRYHSYEAIRQAFRVWEQATPLAFQEVPYEDIRQKRKKEADIMVLFASGFHGDSSPFDGVGGFLAHAYFPGPGMGGDTHFDSDEPWTLENTDVSGNNLFLVAVHELGHSLGLEHSSNPSAIMAPFYQWMDTENFQLPEDDLKGIQQLYGTADGHPQPTKPLPTVTPRRPGRPDHRPPRPPPPGKPERPPKPGNPDRPDQYGPDICDGNFDTVAVLRGEMFVFKGKWFWRVRHNRVLDNYPMPIGHFWRGLPGDIDAAYERHDGRFVFFKGNRYWLFREANLEAGYPQPLTSYGQGIPYDSIDTAVWWEPTGHTFFFRGDRYWRFNEDTRSVDPGYPKPISVWAGIPPSPKGAFLSSDASSTYFYRGTKYWKFDNERLRTEPGYPKSILRDFMGCNVELVPEPSPPRWPDVDRPPFNPDGDETPRDDGDEEEEEEEEDEEDYGEGGREKGGDVDVVVQIDEYTRTMSVVMVLVLLVLLLCILGLIYVIVQMQRKGTPRMLLYCKRSLQEWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TJ67</accession>
    <name>A0A8C2TJ67_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="19">LIM homeobox transcription factor 1 beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LMX1B</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015734983.1">
        <property type="nucleotide sequence ID" value="XM_015879497.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TJ67"/>
    <dbReference type="Ensembl" id="ENSCJPT00005018883.1">
        <property type="protein sequence ID" value="ENSCJPP00005013103.1"/>
        <property type="gene ID" value="ENSCJPG00005011083.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107321958"/>
    <dbReference type="KEGG" id="cjo:107321958"/>
    <dbReference type="CTD" id="4010"/>
    <dbReference type="GeneTree" id="ENSGT00940000157955"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09371">
        <property type="entry name" value="LIM1_Lmx1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09378">
        <property type="entry name" value="LIM2_Lmx1a_Lmx1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000095">
        <property type="entry name" value="LIM homeobox transcription factor 1 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000006">
        <property type="entry name" value="LIM homeobox transcription factor 1-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000257">
        <property type="entry name" value="Transcription factor Lmx1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050453">
        <property type="entry name" value="LIM_Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208:SF96">
        <property type="entry name" value="LIM HOMEOBOX TRANSCRIPTION FACTOR 1-BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208">
        <property type="entry name" value="LIM/HOMEOBOX PROTEIN LHX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8 13 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 13 15" id="KW-0371">Homeobox</keyword>
    <keyword evidence="7 14" id="KW-0440">LIM domain</keyword>
    <keyword evidence="3 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 13 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="17">
        <location>
            <begin position="54"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="17">
        <location>
            <begin position="114"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="18">
        <location>
            <begin position="216"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="13">
        <location>
            <begin position="218"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="176"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005013103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="400" mass="44997" checksum="CCDDFAB329C68C0D" modified="2022-01-19" version="1">MDIASGPESLERCFPRGPTDCAKMLDGIKMEDHPLRSGPATLGVLLGSECPHQAVCEGCQRPISDRFLMRVNESSWHEECLQCAVCQQALTTSCYFRDRKLYCKQDYQQLFAAKCSGCMEKIAPTEFVMRALECVYHLSCFCCCVCERQLRKGDEFVLKEGQLLCKSDYEKEKDLLSSVSPDDSDSVKSDDEDGDVKPTKGQVAQGKGSDDGKDPRRPKRPRTILTTQQRRAFKASFEVSSKPCRKVRETLAAETGLSVRVVQVWFQNQRAKMKKLARRHQQQQEQQNSQRLGQEVMSNRMEGMMTSYTPLAPPQQQIVAMDQSSYGTDPFQQGLTPPQMPGDHMNPYGNDSIFHDIDSDTSLTSLSDCFLASSEVNSMQARVGNPIDRLYSMQSSYFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TJI0</accession>
    <name>A0A8C2TJI0_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">G protein-coupled receptor 137C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">GPR137C</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TJI0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005019500.1">
        <property type="protein sequence ID" value="ENSCJPP00005013602.1"/>
        <property type="gene ID" value="ENSCJPG00005011448.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153986"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21475">
        <property type="entry name" value="7tm_GPR137C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029723">
        <property type="entry name" value="GPR137"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15146">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN GPR137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15146:SF1">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN GPR137C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0458">Lysosome</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <begin position="215"/>
            <end position="238"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="357"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005013602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="393" mass="42852" checksum="30D6EA59C696AE2F" modified="2022-01-19" version="1">MSAVAAGPAPAEGPAVPYAVQLGLTVLHTALYAALFLFAYLQLWLLLYYRERRLSYHTLCLFLCLLWAALRTTLFSFYLQNSLQALRLQQPFAHWLLYCLPGCLLFASLCLLNLYFAEVIFKVKCAADFNKVLLYLGSVLTSLLFLVVNLTCAMLIHSEVPENQLRQTVLARALVNDSLFILCAISLACCMCKLGKMSSANVYLESKGTSVCQAILVGSVVALLYSSRACYNLVAVAISPDNVPGPFNYGWDNLSDKVHVEVSSEEYVVFGVVLFLWELVPTTFVVLFFRAQRLSQNLTPAGMVNSHSYSSRAYFFDNPRRYDSDDDLSRLGAREGGLATPQCSGCYGSLAGNDSYPAGPPPSGAATDSAPLLSAAGGSELSNHHSSHPAAQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TKM8</accession>
    <name>A0A8C2TKM8_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">RAR related orphan receptor A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">RORA</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TKM8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005021682.1">
        <property type="protein sequence ID" value="ENSCJPP00005015269.1"/>
        <property type="gene ID" value="ENSCJPG00005012679.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157387"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004879">
        <property type="term" value="F:nuclear receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008142">
        <property type="term" value="F:oxysterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001223">
        <property type="term" value="F:transcription coactivator binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001222">
        <property type="term" value="F:transcription corepressor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001525">
        <property type="term" value="P:angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071456">
        <property type="term" value="P:cellular response to hypoxia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071347">
        <property type="term" value="P:cellular response to interleukin-1"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036315">
        <property type="term" value="P:cellular response to sterol"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071356">
        <property type="term" value="P:cellular response to tumor necrosis factor"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021930">
        <property type="term" value="P:cerebellar granule cell precursor proliferation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021702">
        <property type="term" value="P:cerebellar Purkinje cell differentiation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046068">
        <property type="term" value="P:cGMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042632">
        <property type="term" value="P:cholesterol homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032922">
        <property type="term" value="P:circadian regulation of gene expression"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042692">
        <property type="term" value="P:muscle cell differentiation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043124">
        <property type="term" value="P:negative regulation of canonical NF-kappaB signal transduction"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045599">
        <property type="term" value="P:negative regulation of fat cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050728">
        <property type="term" value="P:negative regulation of inflammatory response"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006809">
        <property type="term" value="P:nitric oxide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042753">
        <property type="term" value="P:positive regulation of circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010575">
        <property type="term" value="P:positive regulation of vascular endothelial growth factor production"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043030">
        <property type="term" value="P:regulation of macrophage activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008589">
        <property type="term" value="P:regulation of smoothened signaling pathway"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019218">
        <property type="term" value="P:regulation of steroid metabolic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072539">
        <property type="term" value="P:T-helper 17 cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070328">
        <property type="term" value="P:triglyceride homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd06968">
        <property type="entry name" value="NR_DBD_ROR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06939">
        <property type="entry name" value="NR_LBD_ROR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.565.10:FF:000005">
        <property type="entry name" value="Nuclear orphan receptor ROR-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000003">
        <property type="entry name" value="Nuclear orphan receptor ROR-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044101">
        <property type="entry name" value="NR_DBD_ROR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003079">
        <property type="entry name" value="ROR_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45805">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR HR3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45805:SF3">
        <property type="entry name" value="NUCLEAR RECEPTOR ROR-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01293">
        <property type="entry name" value="RORNUCRECPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="13">
        <location>
            <begin position="49"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="14">
        <location>
            <begin position="251"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="134"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="502" mass="57553" checksum="24698E2467DE5130" modified="2022-01-19" version="1">MKRITFDIHEIRDHFTTRGKPVMVDCKEKGRAQICISVTKKTHTSQIEIIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQSNATYSCPRQKNCLIDRTSRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQRDSLYAEVQKHRMQQQQRDHQQQPGEAEPLTPTYNITTNGLTELHDDLSNYIDGHTPEGSKADSAVSSFYLDIQPSPDQSGLDINGIKPEPICDYTPASGFFPYCSFTNGETSPTVSMAELEHLAQNISKSHMETCQYLREELQQITWQTFLQEEIENYQNKQREVMWQLCAVKITEAIQYVVEFAKRIDGFMELCQNDQIVLLKAGSLEVVFIRMCRAFDSQNNTVYFDGKYASPEVFKSLGCEDFISFVFEFGKSLCSMHLTEDEIALFSAFVLMSADRSWLQEKVKIEKLQQKIQLALQHVLQKNHREDGILTKLICKVSTLRALCGRHTEKLIAFKAIYPDIVRLHFPPLYKELFTSEFEPAMQIDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TL58</accession>
    <name>A0A8C2TL58_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">N-terminal E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="2">2.3.2.23</ecNumber>
            <ecNumber evidence="6">2.3.2.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">UBE2W</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.23"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-N-terminal-amino acid = [E1 ubiquitin-activating enzyme]-L-cysteine + N-terminal-ubiquitinyl-[acceptor protein].</text>
            <dbReference type="EC" id="2.3.2.25"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="2"/>
    <dbReference type="EC" id="2.3.2.25" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2TL58"/>
    <dbReference type="Ensembl" id="ENSCJPT00005019988.1">
        <property type="protein sequence ID" value="ENSCJPP00005013969.1"/>
        <property type="gene ID" value="ENSCJPG00005011722.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156908"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23808">
        <property type="entry name" value="UBCc_UBE2W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000022">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="9">
        <location>
            <begin position="128"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00042168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005013969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="302" mass="32907" checksum="79729A6CF07E8F64" modified="2022-01-19" version="1">MSVLHPARPAVSSQPPLRGGSPLPCSAGVSQRPPHARPPHGTQPGSPSAGCNRRRPSARAGSSPLPHIEGSDTKDKTRPPSLPQSSGARPPRLFPAHARRGGRRARGAACVRVRAGGAAGGGGSIMASMQKRLQKELLALQNDPPPGMTLNEKSVQNSITQWIVDMEGAPGTLYEGEKFQLLFKFSSRYPFDSPQVMFTGDNIPVHPHVYSNGHICLSILTEDWSPALSVQSVCLSIISMLSSCKEKRRPPDNSFYVRTCNKNPKKTKWWYHESVMTHLLNDLLLCKSFRSSLTRSICVIPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TN36</accession>
    <name>A0A8C2TN36_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DND microRNA-mediated repression inhibitor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">DND1</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TN36"/>
    <dbReference type="Ensembl" id="ENSCJPT00005020894.1">
        <property type="protein sequence ID" value="ENSCJPP00005014713.1"/>
        <property type="gene ID" value="ENSCJPG00005012253.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159225"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061158">
        <property type="term" value="P:3'-UTR-mediated mRNA destabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007281">
        <property type="term" value="P:germ cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060965">
        <property type="term" value="P:negative regulation of miRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21245">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14709">
        <property type="entry name" value="DND1_DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="58"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005014713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="370" mass="40645" checksum="6FD3E89FB8FB7BF1" modified="2022-01-19" version="1">NATRRDCSQWSVGVSPSSRTALLTWVRETGIHLVQVNGQRRYGGPPPGWVGSVPPPGSEVYIAKLPRDLFEDTLIPLFQSVGQLYEFRLMLTFSGLNRGFAYAKYRDQHSAGKAIAALNNWEVQQGHAILVCRSFEKCQLSVSRLPGTMRRAELVAVLMEATEGLLHLMLHTDPRRRQGKVAVLTYSSHHAAAMAKKALLEGTRGLRGHGVKVEWLKPDLKEQLQEHQEEPPPSNMQRMGSPQRVLPSLEPHGSLCRLGALCQRLHMGTPRFFTRCEQANSSGWQRYWGQVVTPSCSVLCSTFLLVPEDAPGTVGHEKMKEAVAQLALAMLGESIPTSRPGAFPGAGGCGGWMGWKEPCGTSTFFSPAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TN86</accession>
    <name>A0A8C2TN86_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Mannose binding lectin 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">MBL2</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TN86"/>
    <dbReference type="Ensembl" id="ENSCJPT00005021653.1">
        <property type="protein sequence ID" value="ENSCJPP00005015246.1"/>
        <property type="gene ID" value="ENSCJPG00005012664.1"/>
    </dbReference>
    <dbReference type="KEGG" id="cjo:107315596"/>
    <dbReference type="GeneTree" id="ENSGT00940000154368"/>
    <dbReference type="OrthoDB" id="10255512at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905370">
        <property type="term" value="C:serine-type endopeptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106139">
        <property type="term" value="C:symbiont cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:calcium-dependent protein binding"/>
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        <property type="term" value="F:D-mannose binding"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:identical protein binding"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:pattern recognition receptor activity"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:signaling receptor binding"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:activation of membrane attack complex"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:antiviral innate immune response"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:cell surface pattern recognition receptor signaling pathway"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0001867">
        <property type="term" value="P:complement activation, lectin pathway"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0050830">
        <property type="term" value="P:defense response to Gram-positive bacterium"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:killing of cells of another organism"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:leukocyte chemotaxis involved in immune response"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:negative regulation of viral process"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:zymogen activation"/>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="Collagen, type XX, alpha 1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Mannose binding lectin 2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="6-Phosphogluconate Dehydrogenase, domain 3"/>
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    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
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        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051077">
        <property type="entry name" value="Ca-dependent_lectin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
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        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24024:SF42">
        <property type="entry name" value="MANNOSE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24024">
        <property type="entry name" value="PULMONARY SURFACTANT-ASSOCIATED PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0176">Collagen</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0430">Lectin</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034474580" evidence="8">
        <location>
            <begin position="23"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="9">
        <location>
            <begin position="140"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="46"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="51"/>
            <end position="66"/>
        </location>
    </feature>
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        <location>
            <begin position="71"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="254" mass="27045" checksum="A0B75C89722569F9" modified="2022-01-19" version="1">MTLLQPLSAILLCLSLMMATSSLSTEKPEEKMYSCPIIQCSAPAVNGLPGRDGRDGPKGEKGDPGEGLRGLQGLPGKAGPPGLKGEVGPQGVKGQKGERGIDVSDDLHRQITALETKIRVLEDDLNRYKKAMTLKDIVNVGKKMFVSSGKKDNFEKGKSLCAKAGSVLASPRNEAENAALSDLVNPLGSAYLGISDAQTEGRFMYLSGGPLTYSNWKSGEPNNLRNEDCAVIDGSGKWNDLDCSNSNIFIICEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TNE9</accession>
    <name>A0A8C2TNE9_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Family with sequence similarity 149 member B1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FAM149B1</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM149 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015721618.1">
        <property type="nucleotide sequence ID" value="XM_015866132.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TNE9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005021853.1">
        <property type="protein sequence ID" value="ENSCJPP00005015405.1"/>
        <property type="gene ID" value="ENSCJPG00005012775.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107315608"/>
    <dbReference type="KEGG" id="cjo:107315608"/>
    <dbReference type="CTD" id="317662"/>
    <dbReference type="GeneTree" id="ENSGT00530000063727"/>
    <dbReference type="OrthoDB" id="2134133at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061512">
        <property type="term" value="P:protein localization to cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022194">
        <property type="entry name" value="DUF3719"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039630">
        <property type="entry name" value="FAM149"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31997">
        <property type="entry name" value="AGAP003710-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31997:SF0">
        <property type="entry name" value="PRIMARY CILIUM ASSEMBLY PROTEIN FAM149B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12516">
        <property type="entry name" value="DUF3719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3719" evidence="3">
        <location>
            <begin position="112"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="216"/>
        </location>
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        </location>
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            <end position="459"/>
        </location>
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            <end position="529"/>
        </location>
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            <begin position="573"/>
            <end position="602"/>
        </location>
    </feature>
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            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
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    </feature>
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        <location>
            <begin position="201"/>
            <end position="210"/>
        </location>
    </feature>
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            <begin position="348"/>
            <end position="359"/>
        </location>
    </feature>
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        <location>
            <begin position="363"/>
            <end position="373"/>
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    </feature>
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            <end position="455"/>
        </location>
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            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="587"/>
            <end position="602"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00008309"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="602" mass="66161" checksum="8BF99CC753AF8497" modified="2022-01-19" version="1">MIPRYARKPVPPGALQPQGLTQHAVRHHPLPEPSPVTPTAESCPGASSGSEISKHSDYPSVTPTDDGNSWSASLSYTGTSTEDSSIFSWGCDEFDKAATQQVQNVFRQLDELLYEQKGNVHVEGLQEECQQWTSNFPHLRVVGKQIVIPKDEGYEWFSSSPSASLCSSDVSPSQEEGSNEFSVFGKKVPLSVSPVLKKANRSQPPTSCSPDSEEGEDGVIASEGIMEEYLAFDCRDVEEELHERKIGLSSSRRKLGFPPVSPYSCMKDSVLTFVFDDVWSEVLGCMEELISRHWEVSASDDEKNIIKVEAIRADSGSPQQFDPLPVLLPRVPQTKMPSVTSNLCPKPRCGRKTKKRRKAPQVNQGSSSGSQQNLSGLIVIHGIHLQQRNLPVIEKTLDLEDKRPGSSSVLSNKAWPNRPPLELSTSPLSHSSKRRNAPPRTLHPISTSQSRTATPRSVDDVFRGTRLLTAHEQLSSPSPLLLNRNSLLPPIGTTDVAEQASTAGSQRQTKSRGNSSRAHSVTTHEDTHQQLHERLFLPDHFSRPKTTNVFLPDPQHRRSCTVIDYGNHAWTSRTSAGSGLQPHGSVKGQSRSGSVTKNKQGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TNF0</accession>
    <name>A0A8C2TNF0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BMP-2-inducible protein kinase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TNF0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005020404.1">
        <property type="protein sequence ID" value="ENSCJPP00005014314.1"/>
        <property type="gene ID" value="ENSCJPG00005011957.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000008255"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051744">
        <property type="entry name" value="AP2_assoc_SerThr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028182">
        <property type="entry name" value="BMP2K_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47907:SF5">
        <property type="entry name" value="AP2 ASSOCIATED KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47907">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15282">
        <property type="entry name" value="BMP2K_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BMP-2-inducible protein kinase C-terminal" evidence="2">
        <location>
            <begin position="187"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005014314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="400" mass="42380" checksum="877B810AE2A6839B" modified="2022-01-19" version="1">MGSSTENLIPGFQPASSAAQADAFGGSSSFTAGSGLPRDPALFPAVPLGLCKGPTASDGLALYNTQPEVKTQPNAEPDYAARDGPSSNSSFYSSEGEGTDHEGDILDCSGSRPLLLDSEEEEESCRPGSGFMQAGPRERRDVSKEQHPHTQSAEMPFPAFQSHSGEVFNEPDVFATAPFRSSRKAPDEADVFTKAPFISKGSAALQHPEEADVFLRAPFTKKKSMEELLSHSLPKEPLMFISPAADVQHRTTPAFQSLDAVVSGPSTRPQYPSAGFALLTNLPPVRAAEEHSPPPGMQPEPSEPSLAQAGPQECTLNPASNNRPFRPQALSKYSRHYSPEDGPGLDVQPIAAYKVVSQTNRQAIAGSVSVAPLASRTTELPAADPFASAPFPSKAAKQKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TPN2</accession>
    <name>A0A8C2TPN2_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Thrombopoietin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">THPO</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EPO/TPO family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TPN2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005023504.1">
        <property type="protein sequence ID" value="ENSCJPP00005016782.1"/>
        <property type="gene ID" value="ENSCJPG00005013765.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000006294"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008283">
        <property type="term" value="P:cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070374">
        <property type="term" value="P:positive regulation of ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902035">
        <property type="term" value="P:positive regulation of hematopoietic stem cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038163">
        <property type="term" value="P:thrombopoietin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009079">
        <property type="entry name" value="4_helix_cytokine-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019767">
        <property type="entry name" value="EPO/TPO_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001323">
        <property type="entry name" value="EPO_TPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003978">
        <property type="entry name" value="Thrombopoietin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10560">
        <property type="entry name" value="THROMBOPOIETIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10560:SF0">
        <property type="entry name" value="THROMBOPOIETIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00758">
        <property type="entry name" value="EPO_TPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01485">
        <property type="entry name" value="THROMBOPTN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47266">
        <property type="entry name" value="4-helical cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00817">
        <property type="entry name" value="EPO_TPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0372">Hormone</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034911853" evidence="8">
        <location>
            <begin position="28"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005016782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="183" mass="20721" checksum="D54B28D10ABDB5CA" modified="2022-01-19" version="1">MCPRVSPSFPGLLLLTSFLLHVKEGHARPIGPVCDKRLIQKYIGEAKDMEKRVSECQALPALSCPVVLPLVDFNMRQWKSKSDEIKWREILCNLVLLVGAVTEAQGQVSQECGAGQLSQLYRHANSFLLLLQTFGWEEGPWEPGCSPRSIEQTEVTEIFLTYRQLVQGKLRFFFHNLAKDSCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TQA3</accession>
    <name>A0A8C2TQA3_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">3-hydroxyisobutyrate dehydrogenase</fullName>
            <shortName evidence="12">HIBADH</shortName>
            <ecNumber evidence="12">1.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">HIBADH</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>3-hydroxy-2-methylpropanoate + NAD(+) = 2-methyl-3-oxopropanoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17681"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57700"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Amino-acid degradation; L-valine degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.31" evidence="12"/>
    <dbReference type="RefSeq" id="XP_015709335.1">
        <property type="nucleotide sequence ID" value="XM_015853849.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TQA3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005021445.1">
        <property type="protein sequence ID" value="ENSCJPP00005015094.1"/>
        <property type="gene ID" value="ENSCJPG00005012548.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107309225"/>
    <dbReference type="KEGG" id="cjo:107309225"/>
    <dbReference type="CTD" id="11112"/>
    <dbReference type="GeneTree" id="ENSGT00940000155255"/>
    <dbReference type="OrthoDB" id="435038at2759"/>
    <dbReference type="UniPathway" id="UPA00362"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008442">
        <property type="term" value="F:3-hydroxyisobutyrate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000006">
        <property type="entry name" value="3-hydroxyisobutyrate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000119">
        <property type="entry name" value="3-hydroxyisobutyrate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002204">
        <property type="entry name" value="3-OH-isobutyrate_DH-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011548">
        <property type="entry name" value="HIBADH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01692">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981:SF7">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00895">
        <property type="entry name" value="3_HYDROXYISOBUT_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0101">Branched-chain amino acid catabolism</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 11 12" id="KW-0520">NAD</keyword>
    <keyword evidence="6 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="13">
        <location>
            <begin position="39"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="14">
        <location>
            <begin position="200"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="37"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="100"/>
            <end position="101"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU910714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="333" mass="35183" checksum="724A6ECD2EE63C5A" modified="2022-01-19" version="1">MAAAVVLGGPAGWWRWHRRVRAASAAMVCSRAMASKTPVGFIGLGNMGNPMAKNLIKHGYPVIAYDVFPEACKEFQDLGAQVTDSPADVAERADRIITMLPSSPNAIEVYTGANGILKKVKKGSLLIDSSTIDPSVSKELAKAVEKMGAVFMDAPVSGGVGAARAGNLTFMVGGVEQEFDAAKELLICMGSNVVYCGEVGTGQAAKICNNMLLAISMIGTAETMNLGIRLGLDPKLLAKILNMSSGRCWSSDTYNPVPGVMEGVPSANNYQGGFGTTLMAKDLGLAQISATNTKTPVPLGSQAHQIYRMMCAKGYALKDFSAVFQFLREEESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TQZ5</accession>
    <name>A0A8C2TQZ5_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PBX homeobox interacting protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">PBXIP1</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015740046.1">
        <property type="nucleotide sequence ID" value="XM_015884560.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TQZ5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005024209.1">
        <property type="protein sequence ID" value="ENSCJPP00005017358.1"/>
        <property type="gene ID" value="ENSCJPG00005014188.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005024210.1">
        <property type="protein sequence ID" value="ENSCJPP00005017359.1"/>
        <property type="gene ID" value="ENSCJPG00005014188.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107324494"/>
    <dbReference type="KEGG" id="cjo:107324494"/>
    <dbReference type="CTD" id="57326"/>
    <dbReference type="GeneTree" id="ENSGT00960000187391"/>
    <dbReference type="OrthoDB" id="8947092at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051990">
        <property type="entry name" value="CCPG1/PBIP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28638">
        <property type="entry name" value="CELL CYCLE PROGRESSION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28638:SF1">
        <property type="entry name" value="PRE-B-CELL LEUKEMIA TRANSCRIPTION FACTOR-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="189"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="44"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="192"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="207"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="224"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005017358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="422" mass="46904" checksum="D096A3EEFC61DD9D" modified="2022-01-19" version="1">MDVMSHDATDMEQEAMPDNGSDSPQKPPLDAHSMQSMSVLLDRLAKENQDIRLMQAELQAHKEELQALLQQSEGAAAAAGAQQQSLAKENAELRAALQREAEALRAARADLQRLQARGGPIDPQTHKEQPHGPSAAVHGEGARQHGMLASVRHELAAALQRARGAGGLEGVMEELKVLEERLNRELGGAEGAEGHWKKGFKAEKKDRGWHKRDGHRERGKAHGHGKEPYGKEPYRKEPYSKEPHGKEPYSKEPYSKEPHGKEPHGKEPYKEPYSKEPHGKEHRPHREHREGKAGGKWPRSPRELPPLSHPRPPHGCSGVTDCAHKEGREALGAALEPVKKTQFLQLLEGFMGRLGWGGHFGGVAERLDGAFGADGVFAHDRRRFVDFVEEVEEMLEDVARRERSDEEAADGFEEFVLRHYAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TS36</accession>
    <name>A0A8C2TS36_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">arylamine N-acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC107319389</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an arylamine + acetyl-CoA = an N-acetylarylamine + CoA</text>
            <dbReference type="Rhea" id="RHEA:16613"/>
            <dbReference type="ChEBI" id="CHEBI:13790"/>
            <dbReference type="ChEBI" id="CHEBI:50471"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the arylamine N-acetyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.5" evidence="2"/>
    <dbReference type="RefSeq" id="XP_015729629.1">
        <property type="nucleotide sequence ID" value="XM_015874143.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015729630.1">
        <property type="nucleotide sequence ID" value="XM_015874144.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TS36"/>
    <dbReference type="Ensembl" id="ENSCJPT00005025157.1">
        <property type="protein sequence ID" value="ENSCJPP00005018085.1"/>
        <property type="gene ID" value="ENSCJPG00005014708.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107319389"/>
    <dbReference type="KEGG" id="cjo:107319389"/>
    <dbReference type="GeneTree" id="ENSGT00390000012054"/>
    <dbReference type="OrthoDB" id="10260017at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004060">
        <property type="term" value="F:arylamine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2140.20:FF:000001">
        <property type="entry name" value="Arylamine N-acetyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2140.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001447">
        <property type="entry name" value="Arylamine_N-AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053710">
        <property type="entry name" value="Arylamine_NAT_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11786:SF8">
        <property type="entry name" value="ARYLAMINE N-ACETYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11786">
        <property type="entry name" value="N-HYDROXYARYLAMINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00797">
        <property type="entry name" value="Acetyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01543">
        <property type="entry name" value="ANATRNSFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00052838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005018085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="290" mass="33670" checksum="12D3EC672CA289F5" modified="2022-01-19" version="1">MDIKEYFARISYQGSHDKLDLETLTEIFQHHIRAVPFENLSIHCGESIKLDLAATYDKIVRKKRGGWCMENNNLLSWALKTLGYNVTLLGANVYFPEHDAYADDIDHLLLKVVLHDKSYLVDGGFGMAYQIWQPMELISGKDQPQTPGIFRFLEENGTWYLEKVKRKQCVPNHGDSALHNTDKEVCRRVYLFTLQPRDIEEFRARNQHLQTAPDSLFVTKSICSLQTTDGVRALVGWKLTEIKYNYKDNMDLVEIRILADEEMEKTLKEKFNITLDKKFVPTNTSRLSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TU38</accession>
    <name>A0A8C2TU38_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ARF like GTPase 14 effector protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ARL14EP</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015719006.1">
        <property type="nucleotide sequence ID" value="XM_015863520.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032300885.1">
        <property type="nucleotide sequence ID" value="XM_032444994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TU38"/>
    <dbReference type="Ensembl" id="ENSCJPT00005026266.1">
        <property type="protein sequence ID" value="ENSCJPP00005018938.1"/>
        <property type="gene ID" value="ENSCJPG00005015394.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107314365"/>
    <dbReference type="KEGG" id="cjo:107314365"/>
    <dbReference type="CTD" id="120534"/>
    <dbReference type="GeneTree" id="ENSGT00940000156586"/>
    <dbReference type="OrthoDB" id="5984406at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029264">
        <property type="entry name" value="ARF7EP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46536">
        <property type="entry name" value="ARL14 EFFECTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46536:SF1">
        <property type="entry name" value="ARL14 EFFECTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14949">
        <property type="entry name" value="ARF7EP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ARF7 effector protein C-terminal" evidence="2">
        <location>
            <begin position="146"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005018938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="286" mass="32634" checksum="3E322A16B9D0ED4E" modified="2022-01-19" version="1">MDPCSVGVQLQTANECHKTYYTRHTGFKTKDDISSFDLLLLQLRTGMTLSENDTICFHHAKIYIERFEDLQKSCFDPFNMHRKLSKKNLRAIDLHDATFLTAKFGRQFVPGWKLCPKCMQVINGSVDVEAEERQRRKLDSDGRTAKALKSLQFANPGRQTEFTPETSKREKRRLQTKNPSFNSDRQVIPAKSKVYDSQGLLLYNGMDLCDCLDEDCLGCFYACPKCGSNKCGTECRCDRKWLYEQIEIEGGEIIRNKHLGKGLHAAEMNSTVCSQTKNTQTATKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TUR0</accession>
    <name>A0A8C2TUR0_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Translocator protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC107317329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015725387.1">
        <property type="nucleotide sequence ID" value="XM_015869901.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TUR0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005026620.1">
        <property type="protein sequence ID" value="ENSCJPP00005019190.1"/>
        <property type="gene ID" value="ENSCJPG00005015597.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107317329"/>
    <dbReference type="KEGG" id="cjo:107317329"/>
    <dbReference type="GeneTree" id="ENSGT01030000235072"/>
    <dbReference type="OrthoDB" id="9106579at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024579">
        <property type="entry name" value="Bcl2-int_killer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12201">
        <property type="entry name" value="bcl-2I13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005019190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="148" mass="16755" checksum="9AB629F2B8C03EE2" modified="2022-01-19" version="1">MSQAQQSPRHVLLSRYPDRAPEEQTYGSLLAAPDTAEQMELNISSAIQVGHQLALIGDEFNRAYSRKIEDTLLHLARRVAISVFQTWNIIKSVTRSFGNVLNNNWTKRITGYGSWVCRLPFRCVCQKLVLAALLAVAFWWAISHGLQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TWD5</accession>
    <name>A0A8C2TWD5_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TWD5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005025920.1">
        <property type="protein sequence ID" value="ENSCJPP00005018656.1"/>
        <property type="gene ID" value="ENSCJPG00005015185.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01050000244808"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050488">
        <property type="entry name" value="Ig_Fc_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11481:SF64">
        <property type="entry name" value="FC RECEPTOR-LIKE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11481">
        <property type="entry name" value="IMMUNOGLOBULIN FC RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13895">
        <property type="entry name" value="Ig_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="39"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="135"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="280"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="327"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="327"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="364"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005018656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="395" mass="42832" checksum="F2E143FFAF422935" modified="2022-01-19" version="1">MHPSACWCILMHADASQCTLMHPVHAGASHSLPSSPADPLLLQLPVHAVLEGDALSLQCKAQNREISSVSFYHEWKLLQEGHRDQLQLPAATQQHSGRYRCTAYVQSFFSSWSASSQWLMSSYSNLVVQELFSVPELKVEGPQPPPEGSPLPLLCATRRNALRPHVPLQFFFYRDGSVVAGPQSDPQHTVQELLLSHSGSYSCMVQMGHVQKRSPPVTVTVRSERAVGQGGAGGGPMSPQASMDPPIPIWVPISALIARFPSCSQVLKLLPQSPHPFQAFPLHPTSSLPHTSPSPTGSLHPSPDPHPYPGALLLTLAPTLLCSHHPPSSKSAIPSIPSHRRHPWPIPSPNPIAIPSHPIPSHPIHPSQHTSSQSHSQSPFPSHPIPIPIHPISNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TWG5</accession>
    <name>A0A8C2TWG5_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Phospholipid phosphatase 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">PLPP5</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TWG5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005025956.1">
        <property type="protein sequence ID" value="ENSCJPP00005018692.1"/>
        <property type="gene ID" value="ENSCJPG00005015203.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159772"/>
    <dbReference type="UniPathway" id="UPA00085"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000810">
        <property type="term" value="F:diacylglycerol diphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03390">
        <property type="entry name" value="PAP2_containing_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF87">
        <property type="entry name" value="PHOSPHOLIPID PHOSPHATASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="7">
        <location>
            <begin position="82"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005018692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="254" mass="28519" checksum="BDB28697B9305231" modified="2022-01-19" version="1">MPRAAAAITEMCNLLFFSWDMVMELLPPFQRVVQPEEMWLYRNPYVEADRVPTALMFFIAFLSPVLLIILARLFLGADQEDTREACLGEAAYSALLLCPRPRPDFFYRCFPDGRVNTELTCTGDPNVVAEGRKSFPSGHSSFAFAGLAFCAFYLAGKLHCFAPGRRGSALQLCAFLLPLFIATLIAVSRTCDYKHHWQDVLVGSAMGFVLAYLCYRQYYPPLMDSVCHKPLLSISKQLPAHQEKPAASSFHLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TXQ8</accession>
    <name>A0A8C2TXQ8_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FA complementation group A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">FANCA</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="Ensembl" id="ENSCJPT00005025731.1">
        <property type="protein sequence ID" value="ENSCJPP00005018495.1"/>
        <property type="gene ID" value="ENSCJPG00005015064.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000007852"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043240">
        <property type="term" value="C:Fanconi anaemia nuclear complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008585">
        <property type="term" value="P:female gonad development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008584">
        <property type="term" value="P:male gonad development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007140">
        <property type="term" value="P:male meiotic nuclear division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000348">
        <property type="term" value="P:regulation of CD40 signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905936">
        <property type="term" value="P:regulation of germ cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050727">
        <property type="term" value="P:regulation of inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045589">
        <property type="term" value="P:regulation of regulatory T cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003516">
        <property type="entry name" value="FANCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055387">
        <property type="entry name" value="FANCA_arcN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055386">
        <property type="entry name" value="FANCA_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055277">
        <property type="entry name" value="Fanconi_A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031729">
        <property type="entry name" value="Fanconi_A_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12047">
        <property type="entry name" value="FANCONI ANEMIA GROUP A PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12047:SF2">
        <property type="entry name" value="FANCONI ANEMIA GROUP A PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24783">
        <property type="entry name" value="FANCA_arcN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03511">
        <property type="entry name" value="FANCA_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24781">
        <property type="entry name" value="FANCA_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15865">
        <property type="entry name" value="Fanconi_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00826">
        <property type="entry name" value="FANCONIAGENE"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fanconi anaemia group A protein N-terminal" evidence="3">
        <location>
            <begin position="231"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="Fanconi anaemia group A protein helical" evidence="4">
        <location>
            <begin position="603"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="domain" description="Fanconi anaemia group A protein arcN subdomain" evidence="5">
        <location>
            <begin position="705"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="domain" description="Fanconi anaemia group A protein C-terminal" evidence="2">
        <location>
            <begin position="1280"/>
            <end position="1477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005018495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1501" mass="168076" checksum="8D8FE4BC6DE58478" modified="2022-01-19" version="1">MAVTPNPPAPPPPYPLTTLPRAIALPFPTWRPPAPHTPPPPRWRSYDRSTPTILSANRRRHAPPAAANGSAGRGGCFGGRAVMAGAGGGALRELLGRARKRKSTFGSIAELQTAALHLLDHHQNLSDLLLEVGGSDKPAGQGGTEHRELSSESFIVSVLQEQASRLAVPAAVLAAKNAVMKIEQICQSSASPSQAPLLNSDQRERLSCLLRTVKDLLEKNVFSRSHFCQEIWKMKDLPVLEAVWHLHRNGITGLGELLESADGRAVEEWLCSSLCALCEQAEGPPQDTEHAGRVLSDFAIMFLQNGFQPSEMGRKLEFKKVPHICHAVLQRMLTWVLNAVGKEKEEGDSTLQAMRFWLNVFDVSTYKSAVDPDSLQQFFRHTLTEVLTYNPLLKVSDAIHKQKEWSFTRTSSLLTALYRKLFVAFSARELICQLQQVLETHEVNWQHVLSCVSTLVVCQAEAEQLFKDLLSHLLIKAFENYDMENMITAFLIARQAALEGPAVFMPYSEWFKASFGNATGHHGSSKKALVFLFEFLSELVPFEVAPYLKVHIMYPPFVPTKHRSILLEYITLAKTRLADLKVAIEDMGLYEDLSSTHESVQPQGQALRDVEKALQIFENTRKIPTSVIEASIFRRPYYTSWFLPALLRPRVLPKAPDVRMAFIDCLKRADKIPPNLYSTYIQACRASKEKTLQDETKVEPSHSKEPAEQLKAELAALRVLIVDQAKHEDVPAQIAVVSDRLSVVLGHNRDENEAATLNSRIQVNVFDPKLEPRHQSVVDLLLTSFCQNLIAASYFNPPDRQGPCLSLFVKMLCGHRSLIPSLLGRLCQLLYHQGPSLNDAHILGLAAFMIHFCESKSLIPEIEADFGISQPVAEKVLSISEFWSCLLVCRTEESLSFCTRFCTAAVSYLLCKFPSFSCGDLCALVPPSLVKKLQYIVPRLSLEARGSTSKEGQADLVWSSLTCPSLNYRRASLCLWKQARFQELLKEKAFQLSFREWLLLELEMHPEKDVLSASERQDFHYWAIYQWYLPAPSASGGCDGDLEKACGVIIGCILDFSQRLNPGSCGQMKSVSPDILCKLQEMVLELGCRRRTLSGCLDAKRHFLFEILQERLKERHCGSALGEQLWRQQELLLHRRILVGLPASTLIVTCQKGKKTLLDCEDFFHYVNSELKNICSRGYALSYGITAHFFRGLLNASLDCEEPAEGVNDVLTTCQTKCPVVLLSAALWWPRLEPVLCSQWKRLFGAPLPEELERLRECQSSAVGFLSSGRVFPPSGPPWISAAFLHRTVQQQIPRGRERNALRRLGADTEQFLVSLLFFSLMDVISAKIAPKEGVDFQTSLEWALEILQCLEERGISWPLLFLSAEEGSGKYCILHSAASERHKRLLPVAFYSLTPGFHHQLLTREHFFLYVALSLYIQLLQLFVEGKDLPQPEQADPLEVISAARRFLLGAIPRCPAKSFGNIGLLLEACEKLDPEVGATLQHFSGPAAAMEVDEELFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TZ26</accession>
    <name>A0A8C2TZ26_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Caspase-8</fullName>
            <ecNumber evidence="14">3.4.22.61</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LOC107316524</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>Strict requirement for Asp at position P1 and has a preferred cleavage sequence of (Leu/Asp/Val)-Glu-Thr-Asp-|-(Gly/Ser/Ala).</text>
            <dbReference type="EC" id="3.4.22.61"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the peptidase C14A family.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.61" evidence="14"/>
    <dbReference type="RefSeq" id="XP_015723635.1">
        <property type="nucleotide sequence ID" value="XM_015868149.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TZ26"/>
    <dbReference type="Ensembl" id="ENSCJPT00005026033.1">
        <property type="protein sequence ID" value="ENSCJPP00005018768.1"/>
        <property type="gene ID" value="ENSCJPG00005015245.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107316524"/>
    <dbReference type="KEGG" id="cjo:107316524"/>
    <dbReference type="GeneTree" id="ENSGT00940000164225"/>
    <dbReference type="OrthoDB" id="6114029at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00032">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08334">
        <property type="entry name" value="DED_Caspase_8_10_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08333">
        <property type="entry name" value="DED_Caspase_8_r1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.533.10:FF:000016">
        <property type="entry name" value="CASP8 and FADD-like apoptosis regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.533.10:FF:000038">
        <property type="entry name" value="Caspase 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1460:FF:000008">
        <property type="entry name" value="caspase-8 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033170">
        <property type="entry name" value="Caspase-8_DED1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033139">
        <property type="entry name" value="Caspase_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016129">
        <property type="entry name" value="Caspase_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
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        <property type="entry name" value="Pept_C14A"/>
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        <property type="entry name" value="CASPASE 10"/>
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        <property type="entry name" value="DED DOMAIN-CONTAINING PROTEIN"/>
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        <property type="entry name" value="DED"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="Peptidase_C14"/>
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        <property type="entry name" value="Caspase_ICE"/>
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        <property type="entry name" value="IL1BCENZYME"/>
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        <property type="entry name" value="CASc"/>
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        <property type="entry name" value="Caspase-like"/>
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        <property type="entry name" value="CASPASE_HIS"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="11" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="DED" evidence="18">
        <location>
            <begin position="4"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="DED" evidence="18">
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            <begin position="102"/>
            <end position="179"/>
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    </feature>
    <feature type="domain" description="Caspase family p20" evidence="20">
        <location>
            <begin position="222"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Caspase family p10" evidence="19">
        <location>
            <begin position="366"/>
            <end position="451"/>
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    </feature>
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        <location>
            <position position="298"/>
        </location>
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    <feature type="active site" evidence="16">
        <location>
            <position position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00004123"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00010134"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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            <dbReference type="ARBA" id="ARBA00022703"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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            <dbReference type="ARBA" id="ARBA00022801"/>
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            <dbReference type="RuleBase" id="RU003971"/>
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            <dbReference type="PROSITE" id="PS50168"/>
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            <dbReference type="PROSITE" id="PS50207"/>
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        <source>
            <dbReference type="PROSITE" id="PS50208"/>
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        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005018768.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="454" mass="51821" checksum="D094CDD757F4FFDA" modified="2022-01-19" version="1">MSSDFQKLLFDISEALATEELEALKFLSLEHVPVRKQENTEDPKAFFEVLKEKGMIQVGDVFFLKELLYRINRIDLLASHLGSSREEMERELQVPGKAKVSAYRQLLYGIAEDLTPEDDSSVKFLLQEKLPKNKLRENASMLKVLVEMERNEIIKEDDVTILKSKLKSFRADLVKRIEKYEEKTRENDSNKNLSFPVCVSVQPPGQGAASLFVESYKMENNPHGYCVILNNYRFKNPDETREGTVQDGDALKRVFKWLQFNTIEHMNLEAKQMFAKLKEYSKKDHSNMDCFVCFILSHGEKDKIKGVDHELVNIKDLVSCFSGSNCPSLAGKPKLFFIQACQGSVGHPAVTVKEDCSDHLETDATPLPSIPDRADVLVGMATVEDFECYRCKHTGSVYIQCLCDKLELLCPLRKDLITILTEVNKEVGRKELNGCKQMPKITSTLRKQFIFQIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U1K6</accession>
    <name>A0A8C2U1K6_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Inner centromere protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">INCENP</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Chromosome</location>
            <location evidence="4">Centromere</location>
            <location evidence="4">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Midbody</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the INCENP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2U1K6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005030036.1">
        <property type="protein sequence ID" value="ENSCJPP00005021922.1"/>
        <property type="gene ID" value="ENSCJPG00005017505.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00730000111073"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032133">
        <property type="term" value="C:chromosome passenger complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990385">
        <property type="term" value="C:meiotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051257">
        <property type="term" value="P:meiotic spindle midzone assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051310">
        <property type="term" value="P:metaphase chromosome alignment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.3600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022006">
        <property type="entry name" value="INCENP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005635">
        <property type="entry name" value="Inner_centromere_prot_ARK-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13142">
        <property type="entry name" value="INNER CENTROMERE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13142:SF1">
        <property type="entry name" value="INNER CENTROMERE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03941">
        <property type="entry name" value="INCENP_ARK-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12178">
        <property type="entry name" value="INCENP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="16" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromosome passenger complex (CPC) protein INCENP N-terminal" evidence="19">
        <location>
            <begin position="6"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="Inner centromere protein ARK-binding" evidence="18">
        <location>
            <begin position="759"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="47"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="176"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="245"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="413"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="562"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="272"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="562"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="579"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="605"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="718"/>
            <end position="741"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004214"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00010042"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF03941"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF12178"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005021922.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="852" mass="98125" checksum="DDD9A1568DFA1AE8" modified="2022-01-19" version="1">MAMAAGLARLPAVCNQRLAELLRQVDDADMVWLEEIREEAARMFGSHYNEQPELMPKTPSQKNRKRRKRPSALRGESMELGRRRLSRRRTNNRKAVSSTRCSQRRQNKEDAGALSAEAQEPSSQTVSRWMTRSQVAASANCSEVLSEQLGERVVPVVEISVRDRISAEFQFQKRASEIAENHPTDLPLSSNDKSPKESSAAESQPLPDVSELTVPHTPEAKGSEKNKSASKKTANVANTTFVLSEASGLEEVDDSAQAQKHNGRDDKEPQRTTDSPETPTGSRLSRRSVRRSLMGKPSTIRRTSLAEKYSLAQKRESAIRKSIARTVIKHKAPQKLSVSSSFVNGEFEHHWLCALHCFLLLLSDDFQGMRMSLRSQAGNKNEQQKTSNNGNFQSFTFSHRRKTSYKRAVDQRYDTQQAEDGGLSPQRKKTLSPPCPASKVVRPFKTFLHTVQKNQLLMTPSSVGRNGVIKSFIKYNTPIQHDPKEKERQKLQALKKKEEAEQLRKQKVEEEKKRRLEEAKLRREERLRKVLQARERAEQLEEERKRRIEQKLALFEEKTEKVREERLAEEKIKKRAAAKKMEEAEARRKQDEEARKQKALQQEEEERRHKELMQKKKEEEQERARKIAEQRQAEQEREKQLAAERELERKKEQERIQAEKQREQQEKAARLQKEALAAKEQIQKEAEKKEKEEQLLAEVKRQEQEQKKLPKEQKATDVAQTQHLENKENSPACNSYQMTPQNHKDPKPPKINPNNYGMDLNSDDSTDDESQPRKPIPAWASGNQLSQAIIRQYYNPPNVDALFGTIVSPKLEDIFYKSKPRYFKRTSSAVWNSPPFPGAKSVLGLPYGLKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U2Q0</accession>
    <name>A0A8C2U2Q0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">thioredoxin-dependent peroxiredoxin</fullName>
            <ecNumber evidence="2">1.11.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PRDX4</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2U2Q0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005029610.1">
        <property type="protein sequence ID" value="ENSCJPP00005021566.1"/>
        <property type="gene ID" value="ENSCJPG00005017260.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153430"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140313">
        <property type="term" value="F:molecular sequestering activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008584">
        <property type="term" value="P:male gonad development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000255">
        <property type="term" value="P:negative regulation of male germ cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd03015">
        <property type="entry name" value="PRX_Typ2cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000003">
        <property type="entry name" value="Peroxiredoxin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050217">
        <property type="entry name" value="Peroxiredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681:SF171">
        <property type="entry name" value="PEROXIREDOXIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681">
        <property type="entry name" value="THIOREDOXIN PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="10">
        <location>
            <begin position="149"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="27"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005021566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="341" mass="38206" checksum="EAA5B2C333B15AEC" modified="2022-01-19" version="1">MRSPHNLLYAEQTQLPQPVLIGEVLQPPTAGRTRSPWRRSAAGRWRGPARSVGRPSSSPLPPLRAAWRGRAVVVWAMEAARRGPRAGVGSSALLLALLLHGATAAEAEEPRSQRQRGDEQCHYYAGGQVYPGEAARVPVTDHSLHLSQAKISKPAPYWEGTAVINGEFKELKLTDYEGKYLVFFFYPLDFTFVCPTEIIAFSDRIEEFRAINTEVVACSVDSKFTHLAWINTPRKQGGLGPMKIPLLSDITHQISKDYGVYLEDQGHALRGLFIIDDKRILRQITMNDLPVGRSVDETLRLVQAFQYTDKHGEVCPAGWKPGSETIKPEEAMRVWWPREEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U338</accession>
    <name>A0A8C2U338_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Calcium dependent secretion activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">CADPS</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Synapse</location>
        </subcellularLocation>
    </comment>
    <dbReference type="Ensembl" id="ENSCJPT00005030999.1">
        <property type="protein sequence ID" value="ENSCJPP00005022612.1"/>
        <property type="gene ID" value="ENSCJPG00005016828.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00590000083094"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050432">
        <property type="term" value="P:catecholamine secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045921">
        <property type="term" value="P:positive regulation of exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099525">
        <property type="term" value="P:presynaptic dense core vesicle exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016082">
        <property type="term" value="P:synaptic vesicle priming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016050">
        <property type="term" value="P:vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01234">
        <property type="entry name" value="PH_CADPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000007">
        <property type="entry name" value="Calcium-dependent secretion activator 2 isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033227">
        <property type="entry name" value="CAPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057457">
        <property type="entry name" value="CAPS_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010439">
        <property type="entry name" value="MUN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014770">
        <property type="entry name" value="Munc13_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12166">
        <property type="entry name" value="CALCIUM-DEPENDENT SECRETION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12166:SF6">
        <property type="entry name" value="CALCIUM-DEPENDENT SECRETION ACTIVATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25341">
        <property type="entry name" value="C2_CAPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06292">
        <property type="entry name" value="MUN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01145">
        <property type="entry name" value="DUF1041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51258">
        <property type="entry name" value="MHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="8" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="C2" evidence="14">
        <location>
            <begin position="358"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="13">
        <location>
            <begin position="499"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="MHD1" evidence="15">
        <location>
            <begin position="925"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1325"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005022612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1347" mass="153111" checksum="18375924F6D9E361" modified="2022-01-19" version="1">MLDPSSSEEESEELVEEESGKEPLAPAAARLSPSRPGDSPGPGPGGGGGGSGGLQPGGRAGGAARPASPSPSVASEKEKDELERLQREEEERKRKLQLYVFVMRCIAYPFNAKQPTDMARRQQKISKQQLQTLKERFQAFLNGETQIVADEAFINAVQSYYEVFLKSDRVARMVQSGGCSANDSREVFKKHIEKRVRSLPEIDGLSKETVLSSWMAKFDAIYRGEEDPRKQQARMTASAASELILSKEQLYEMFQNILGIKKFEHQLLYNACQLDNPDEQAAQIRRELDGRLQLAEQIAKERKFPKFVSKEMENMYIEELKSSVNLLMANLESMPVSKGGSEFKLQKLKRSHNTSIIDMGEENENQLSKSDVVLSFSLEVVIMEVQGLKSLAPNRIVYCTMEVEGGEKLQTDQAEASKPTWGTQGDFTTTHALPAVKVKLFTESTGVLALEDKELGRVVLHPTPNSPKQSEWHKMTVSKNCPDQDLKIKLAVRMDKPQNMKHSGYLWAIGKNVWKRWKKRFFVLVQVSQYTFAMCSYREKKAEPQELLQLDGYTVDYTDPQPGLEGGRAFFNAVKEGDTVIFASDDEQDRILWVQAMYRATGQSHKPVPPTQVQKLNAKGGNVPQLDAPISQFYADRAQKHGMDEFISSNPCNFDHASLFEMVQRLTLDHRLNDSYSCLGWFSPGQVFVLDEYCARNGVRGCHRHLCYLRDLLERAENGAMIDPTLLHYSFAFCASHVHGNRPDGIGTVTVDEKERFEEIKERLRVLLENQITHFRYCFPFGRPEGALKATLSLLERVLMKDIVTPVPQEEVKTVIRKCLEQAALVNYTRLSEYAKIEGKKREMYEHPVFCLASQVMDLTIQNQKDAENVGRLVTPAKKLEDTIRLAELVIEVLQQNEEHHAEAFAWWSDLMVEHAETFLSLFAVDMDAALEVQPPDTWDSFPLFQLLNDFLRSDYNLCNGKFHKHLQDLFAPLVVRYVDLMESSIAQSIHRGFERESWEPVKSLTSNLPNVNLPNVNLPKVPNLPVNIPLGIPQMPSFSAPSWMAAIYDSDNGSGTSEDLFWKLDALQTFIRDLHWPEEEFGKHLEQRLKLMASDMIESCVKRTRIAFEVKLQKTSRSTDFRVPQSICTMFNVMVDAKAQSTKLCSMEMGQEHQYHSKIDELIEETVKEMITLLVAKFVTILEGVLAKLSRYDEGTLFSSFLSFTVKAASKYVDVPKPGMDVADAYVTFVRHSQDVLRDKVNEEMYIERLFDQWYTSSMNVVCTWLTDRMDLQLHIYQLKTLIRIVKKTYRDFRLQGVLDSTLNSKTYETIRNRLTVEEATASVSEGGGLQGITMKDSDEEDEEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U3D2</accession>
    <name>A0A8C2U3D2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tudor-interacting repair regulator protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">NUDT16-like protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Protein syndesmos</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">NUDT16L1</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Nudix hydrolase family. TIRR subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2U3D2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005028326.1">
        <property type="protein sequence ID" value="ENSCJPP00005020546.1"/>
        <property type="gene ID" value="ENSCJPG00005016528.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000016224"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18869">
        <property type="entry name" value="NUDIX_U8_SnoRNA_DE_Nudt16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000038">
        <property type="entry name" value="Tudor-interacting repair regulator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054754">
        <property type="entry name" value="NudT16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31699">
        <property type="entry name" value="NUDIX T16 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31699:SF6">
        <property type="entry name" value="TUDOR-INTERACTING REPAIR REGULATOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22327">
        <property type="entry name" value="Nudt16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00061347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00073440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00076880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00079630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005020546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="312" mass="33334" checksum="06C7F15A2052EF02" modified="2022-01-19" version="1">MGVMAAVGALPAGAGTLPPLPTLGVPGVPELKPLTRYEAMRLGPGWSHSCHAMLYAPNPDGTGRWGPGPGRGSGRRMQMRFDGLLGFPGGFVDRRYWSLEDGLNRVLGLGLGCVRLTEADYLCSHLTDGPHRVVAHLYARQLTLEELHAIEISAVHSRDHGLEVMGMVRVPLYTQKDRMGGLPNFLANSFVGPAKFQLLFALKILNMVPEEKLAEAVATTQKPKKPVIDHAAIAAAKHANELAAAARAGNEYSDSGDHQAAELAEQQAAGLESRAVLEHLAAVPGHEAMVAELHGQPRADSVLEHQVGEAME</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U3R4</accession>
    <name>A0A8C2U3R4_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serpin family B member 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">SERPINB5</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the serpin family. Ov-serpin subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015710071.1">
        <property type="nucleotide sequence ID" value="XM_015854585.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015710072.1">
        <property type="nucleotide sequence ID" value="XM_015854586.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U3R4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005028783.1">
        <property type="protein sequence ID" value="ENSCJPP00005020922.1"/>
        <property type="gene ID" value="ENSCJPG00005016776.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107309634"/>
    <dbReference type="KEGG" id="cjo:107309634"/>
    <dbReference type="CTD" id="5268"/>
    <dbReference type="GeneTree" id="ENSGT00940000160674"/>
    <dbReference type="OrthoDB" id="671595at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001533">
        <property type="term" value="C:cornified envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016528">
        <property type="term" value="C:sarcoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002009">
        <property type="term" value="P:morphogenesis of an epithelium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050678">
        <property type="term" value="P:regulation of epithelial cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.39.10:FF:000014">
        <property type="entry name" value="Serpin family B member 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000240">
        <property type="entry name" value="Serpin_B9/Maspin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023795">
        <property type="entry name" value="Serpin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461:SF55">
        <property type="entry name" value="SERPIN B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00676">
        <property type="entry name" value="MASPIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00093">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00284">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serpin" evidence="2">
        <location>
            <begin position="15"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005020922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="377" mass="42652" checksum="4C04D7648442BB88" modified="2022-01-19" version="1">MTMDALQLANTAFAVDMFKKLCEKDKTTNIVFAPLCTSTSLALAYKATKGDTADQMKKVLHLQDVKDVSFGFQTVTADVSKLTSFFALKMVKRLYVDKSLSPTTDFVNSTKRPFPSELELVEFKEKTEETRQKINKSLSELTDGKMENILNEDSVSDQTQILLVNAAYFVTNWMKKFPEAEIKECPFKVNKTETKPVQMMNLEATFCLGYVKELNVSILELPCLNKHISMLILLPKDIEDETTGLEKLEKALTPETLLQWTNPSMMANTKVNVFLPKFSVEGDYDLKPLLESLGMTNVFNESASDFSEMCETKGVVLSKIVHKVSLEVNEQGGESLEVPGYRILQHKDEFKADHPFIFLFRHNKTRTVILSGRFCSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U3S3</accession>
    <name>A0A8C2U3S3_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AMMECR nuclear protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">AMMECR1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U3S3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005029546.1">
        <property type="protein sequence ID" value="ENSCJPP00005021521.1"/>
        <property type="gene ID" value="ENSCJPG00005017217.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000010397"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.700.20:FF:000001">
        <property type="entry name" value="AMME syndrome candidate gene 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.700.20">
        <property type="entry name" value="Hypothetical protein ph0010, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023473">
        <property type="entry name" value="AMMECR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036071">
        <property type="entry name" value="AMMECR1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002733">
        <property type="entry name" value="AMMECR1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027485">
        <property type="entry name" value="AMMECR1_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00296">
        <property type="entry name" value="TIGR00296 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13016">
        <property type="entry name" value="AMMECR1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13016:SF2">
        <property type="entry name" value="NUCLEAR PROTEIN AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01871">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143447">
        <property type="entry name" value="AMMECR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51112">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMMECR1" evidence="2">
        <location>
            <begin position="115"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005021521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="329" mass="34887" checksum="54DDD573E30BD189" modified="2022-01-19" version="1">MGRKRCVGGDGSKMAAGCCGVKKQKLSSSPPSGSAGPGGGGGGSHCGGAAAAGGEPGALPPPGGPRLNGLGGLAGGAAGCALAPPLPPSCGGGPAGLSPPAASLLASPGAGSGGPGCRKMVVSAEMCCFCFDVLYCHLYGYQPPRSPRFTNDPYPLFVTWKIGRDKRLRGCIGTFSAMNLHSGLREYTLTSALKDSRFPPMTRDELPRLFCSVSLLTNFEDASDYLDWEVGVHGIRIEFINEKGSKRTATYLPEVAKEQGWDHIQTIDSLLRKGGYKAPITNEFRKTIKLTRYRSEKMTMSYTEYLAHRQHHHFQNGIGHPLPPYNHYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U3Z0</accession>
    <name>A0A8C2U3Z0_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NMDA receptor synaptonuclear signaling and neuronal migration factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">NSMF</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2U3Z0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005030651.1">
        <property type="protein sequence ID" value="ENSCJPP00005022363.1"/>
        <property type="gene ID" value="ENSCJPG00005017769.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000000459"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071371">
        <property type="term" value="P:cellular response to gonadotropin stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001224">
        <property type="term" value="P:positive regulation of neuron migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048168">
        <property type="term" value="P:regulation of neuronal synaptic plasticity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058542">
        <property type="entry name" value="IQ_SCN5A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033374">
        <property type="entry name" value="NSMF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32061">
        <property type="entry name" value="NMDA RECEPTOR SYNAPTONUCLEAR SIGNALING AND NEURONAL MIGRATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24609">
        <property type="entry name" value="IQ_SCN5A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCN5A-like C-terminal IQ motif" evidence="5">
        <location>
            <begin position="235"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="29"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005022363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="517" mass="59444" checksum="EFBD9F076A2AC78D" modified="2022-01-19" version="1">VCAAATDRRLLLLRGSSKVAARAFGEYLSQNHPEGRNGSDHLLADSYIGQEDSPEMQQAAQNKRRLSVISDGKFERSFSEEQTEKMPSEGPKPRVYTISGERPMLSDHENESMELVVMKGAAQEECHHGHPVHGAGGSHGVSRHCKGWPGSRQGSKECPNCTRLAAPSHHSFDLEPHQSGETGWHRKKLERMYSVDRVSDDVPIRTWFPKENLFSFQTATTTMQAAFRGYAERKRRKRENDSAAVIQRNFRKHLRMVGSRRVKAQTFAERRERSFSRSWSDPTPIKADSFHDSRESHDLQDSCGTLDGDFDLNWEAEKELEAMACDGEDFIPPKIMLISSKVPKAEYVPTIIRRDDPSIIPILYDHEHATFDDILEEIEKKLNVYRKGCRIWKMLIFCQGGPGHLYLLKNKVATFAKVEKEEDMILFWKRLSRLMSKINPEPNIIHIMGCYVLGNPNGEKLFQNLKNLMNPYRVAFESPLELSAQGKQMIETYFDFRLYRLWKTRQHSKLLDYDDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U553</accession>
    <name>A0A8C2U553_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">aromatase</fullName>
            <ecNumber evidence="10">1.14.14.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Cytochrome P-450AROM</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Estrogen synthase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.14" evidence="10"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2U553"/>
    <dbReference type="Ensembl" id="ENSCJPT00005032193.1">
        <property type="protein sequence ID" value="ENSCJPP00005023496.1"/>
        <property type="gene ID" value="ENSCJPG00005018628.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00840000129915"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070330">
        <property type="term" value="F:aromatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008585">
        <property type="term" value="P:female gonad development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032355">
        <property type="term" value="P:response to estradiol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF43">
        <property type="entry name" value="AROMATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U566</accession>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
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                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
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        </citation>
        <scope>IDENTIFICATION</scope>
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            <authorList>
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            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <text evidence="14">Involved in the control of early migration of neurons expressing gonadotropin-releasing hormone (GNRH neurons). May be involved in the maintenance of osteochondroprogenitor cells pool.</text>
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            <topology evidence="1">Single-pass membrane protein</topology>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <keyword evidence="8" id="KW-0677">Repeat</keyword>
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    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005022855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="2580" mass="279071" checksum="8526870F5CF84AB6" modified="2022-01-19" version="1">MGAPRRCWLRPLLAACLAARLAALPAACPRLCACYGPAEVHCTFRYFTAVPPHIAPDVERINLGYNSLLTLSDTDFAGLEKLELLMLHSNEINAIPDKVFRDLHSLQVLKMSYNKVSVLQQDAFYGLKSLVRLHMDHNVIEFVNPNVFYGLTSLRLVHLEGNLLKQLHPDTFVTLSYLQIFKVSSIKHLHLSDNALTLLPQEMFSYLSELESIYLHGNPWSCDCNLQWIAEWAKQRPDVIKCKKDRSSGAQQCPVCASPRNCKGKNVVGIPPAALTCAKPVIRHTLKLKNLTEPEDGDSSSVSPKDFLAPIGSMVLNMTDQGGNRGNLFCNIQKPKEMSPISFDKEDNVITLNTSFSSFLMCDITYGHIQQLWSILALYSSSPLKLKRSALITETSFITYQYKQIYSEKDELFTNVEAELRAEPSWLMQNKVALQLDRTATTLSTLHIQYFTDAQVTLPAVDQKKVGNNWTMIPRDNKTQTEHTVLVGGTVQLDCQAIGEPAPAIEWILADGSKVRAPYVSEDGRIIVVESGTFTLRTADTFDTGLYHCIGTNYNDADILTFRITVVDPYVEHSSVNGAQLSTTVGSILDLPCTSTAVPDAAISWVLPEHMVLHHSLGNKHIFDNGTLRIQGVTERDSGYFRCVAASQYGVDLLIFQVLVREDKSTPQKVPVAAGEWEESDGSGDALLPPARGKQNSSAALLTWTGQEPTAPARRQQGTHSTRTGSGRRRMPSHLHRDKASRRLRGHRRHFGSSAKKANPQRWAAFLEKAKRNPPGIEKQEVETNPPVQVREFSREPVDEEETSGEPISPEQEFMIAVTERTVTERATASPLGSTEGSSTPAGAGTPPPTPFPHPSPSASPTPADPNPMATTSDSLERPSLSQTPANVGKQSAAAEGASRASALIRAQQRSASPGEHNSGHLKAVSVTAMRSVTDSSTPATSQNAVGEMRGFTEVTDKISTKTGGQAPAETVSEPNPEFGHIYFHSAQKPATPALSLGLNIVTHQHTQTIWDVTTHTPRAQQQHGRRRKISGRRRMVRPGRLLSMRGHRRNSGKQGSARGRTATAPAVLLSSTHSPNLPALSNSHSSINLLSPEVPLPSPSTTNTPSEHPAGTAQSTAFLMEENSAPTARQGATSTAVPVSTQSTGDAAQQEAESRAPRHSSTYRAQPDSSRLPTTATRTAHSAEITQMMSTRTASAPQSFFSRSSSKDTLGGAITRAFLFGNDPQKEALRTDAFPPTEVSALFPKTTVAASRPHVSPLPFTPISSGVNHRAGFPSLGKPPYSSNTSEKPPACSPAVSTAGRMGRESLKPTTTAPTARQTNAKMTSKLFRTGRRRSQRRRRPPKPAPSQSPAIGTHTTSDTASATTAAVSLPAAPTRHTSAAAVSDSPPAGWVTALWALVPPGTAQHRHTAAPQTEAAPSIGVSTPVMSLLPHSTPPQTPTAMNPTLAPPSEPLGATHAHPAAVSAAAHSEPTWQLKAFTPAAEQPNLGTDEEAMQGGPVAQPTAPGSTKPSSRALGTAVPQAQHPTPALPMWGISAGLPSAEWGGKTLTANTPTMPTLRQVAAPHAHLWGSSAYGWSDQKQHHESITSIPPSLFSLSRNYFTKPRITGGKLAAFTVLANSDAFIPCEATGNPQPTIEWTKISPGKLETDAPASGSRWMVLPNGTLAIAQAALQDGGQYRCTATNALGTAQLLATLAVVAYPPRIAGGTRLLTAHAGVPVTMRCPAEGRPPPSISWVLANETHISSSSQGNQKVLVWPDGTLMIKDVTVYDRGLYTCTATNPAGTDTLTVKLQVIAAPPIILEEKRQQITAMAGQDLNLPCTAEGNPQPHVHWVLAKGTVVKPLQFVNTRVLMLPNGTLRLSSIAPTDSGNYECIATSSTGSERRVVILTVPHRDTLPRIAAASQGTTQLSFGDKLLLNCTATGEPQPRIIWRLPSKAVVDQWHRMGSRIHVYPNGSLVIEAVTEKDAGDYLCVARNKLGDDLILMKVSITMKPAKIDHKQYFKKLVPYGKDFQVDCKASGSPAPEISWSLPDGTVINNVMQADDSGHRSRRYVLFDNGTLYLNRAGATEEGDYTCYAQNTLGRDEMKVHITVVTAAPQIKHSYKTYIKVKAGDTALMDCEAAGEPKPKIFWLLPSSDMISSSTDRHLLHANGSLSVHRAKLLDAGEYMCVARNAGGDDTKLYKLHVDAKPPIINGLYTNRTIIKVTAVRHSKKQIDCRAEGTPPPQIMWIMPDNIFLTAPYYGSRIIIHRNGTLEIRNLRPSDTADFICVARNDWGESMLVVQLEVLEMLRRPMFKNPFNEKIIAIPGKTTTLNCSVDGNPPPEVSWMLPNGTWISKGARMSEFLLGSNGTLTILNSSRDKAGKYRCAAKNQVGYIEKLIVLEVAQKPTILIHPKGPVRGISGESLSLHCLSDGNPKPSTAWTLPGGQVLDRPQINSRHILLENGTLVIRAATIHDRGHYVCKAHNPAGDLSITIPVTIIAYPPRITNRPPQTIHTMPGAAVQLSCTALGIPKPEITWELPDHSTLSTGKHGRAPGSELLHPQGTLLIRNPQPSDSGTYKCTAKNHLGSDFTVTYIHVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U6X3</accession>
    <name>A0A8C2U6X3_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Bromodomain-containing protein 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BRD9</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2U6X3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005031065.1">
        <property type="protein sequence ID" value="ENSCJPP00005022676.1"/>
        <property type="gene ID" value="ENSCJPG00005018029.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183170"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016514">
        <property type="term" value="C:SWI/SNF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140566">
        <property type="term" value="F:histone reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05513">
        <property type="entry name" value="Bromo_brd7_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000022">
        <property type="entry name" value="Putative bromodomain-containing protein 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051831">
        <property type="entry name" value="Bromodomain_contain_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021900">
        <property type="entry name" value="DUF3512"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22881">
        <property type="entry name" value="BROMODOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22881:SF4">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12024">
        <property type="entry name" value="DUF3512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="2" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromo" evidence="10">
        <location>
            <begin position="159"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="543"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="78"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="117"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="553"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005022676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="603" mass="68157" checksum="54921B3100A3C319" modified="2022-01-19" version="1">MGKKHKKHKADKAEWRSASTTAYSDKPLEKPLKLVLKVGGSEVTELSGSGHDSSYYDDRSDHERERHKEKKKKKKKKSEKEKEKHLDDEERRKRKEEKKRKREKEQCDTEGETDDFDPGKKVEVEPPPDRPVRACRTQPAENESTPIQRLLEHFLRQLQRKDPHGFFAFPVTDAIAPGYSMIIKHPMDFGTMKEKIAANEYKSVTEFKADFKLMCDNAMTYNRPDTVYYKLAKKILHTGFKMMSKQAALLGDEDTVVEEPVPEVMPVQVETTKKSKKQNKEVISCIFEPEGNACSLTDSTAEEHVLALVEHAADEARDRINRYLPNSKIGYLKKHGDGTLLFSVVNSSDPEAEEEETHPVDLSSLSSKFLPAFTSLGFKDERRNKVTFLTSASTALSMQNNSIFHDLKSEEMELLYSAYGDETGIQCALSLQEFVKDAGHYSKKIVDDLLDQITSGDHSKTVYQLKQRRNIPVKPLDDVKVGESAGDSNASELDFLSMKSYSDVSLDISMLSSLGKVKKELDHDDNHLHLDETAKLLQDLHEAQADRVGSRPSSNLSSLSNTSERDQHHLGSPSHLSVGEQQDIVHDPYEFLQSPETSNATSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U9Z6</accession>
    <name>A0A8C2U9Z6_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thymocyte expressed, positive selection associated 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">TESPA1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U9Z6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005034802.1">
        <property type="protein sequence ID" value="ENSCJPP00005025596.1"/>
        <property type="gene ID" value="ENSCJPG00005020085.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160763"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome LGE22C19W28_E50C23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029325">
        <property type="entry name" value="ITPR-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043444">
        <property type="entry name" value="TESPA1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17469:SF1">
        <property type="entry name" value="PROTEIN TESPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17469">
        <property type="entry name" value="SPERM SPECIFIC ANTIGEN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14722">
        <property type="entry name" value="KRAP_IP3R_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01257">
        <property type="entry name" value="KRAP_IP3R_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ITPR-interacting" evidence="2">
        <location>
            <begin position="306"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="580"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005025596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="720" mass="77879" checksum="E7C2E1FECD4FC6C1" modified="2022-01-19" version="1">MEMAMRMRMEEGLLEDCMGHRQSGKALSYGKHQALKKPQKKPHLVLCSPLQYIAVMLWVCHAQVQTSPILTVSPCARGSPNPPIPTMEGSSVLSPSSWERRRAWARQSRCWRTTVMEEEAAAAMQDIPELQPPHLDDVFMEGSSSSKIETWLQDCGSSSEALQEELSSLGPYGWESSSTSFEDDLTLGAEGSSPPWGSLHVPNTLSIHWGWEQPYGAADTNPVPKPPPMSPAIPCHFCASYLQPFCYRGMRKPSAGESWSPAPHLSPTSQPHISAPHLSPTALLCPQGCPQAVTPRAISPCRALQGRLSLGHSMASSAPSGLTNRTGSSISEVLDWCQADAEEILYDLGFVQSDPGALTRVPSRFFSSPSQAKGIDFQLFLKSQVQRLEMEDPCLMLASRFHQVQALAATADAFFCLYSYVSKTPLQRISPSPLTWTHPNNPQPHIPPSQPPTLSPAERLRAAVSKMCLYTPPLGRVVREVLERSRGERFRFDPNDVDGLGWGGGCGVAVGVMPHRGSSWLDPIRGHQGRMEKDGGCGQSSTGGGLVWGGGSLCPPGIGWGDTKDGQPWVNPPSTQLGHNGVPQTPPMGMDGGQHPGEPTDPHGALPPPSHCAAGGDQWGEQSRGWHRGGDAEWRPPWKGPFVGSFVSHHPKWAESNEAVDSFEMEEVRRGLQGLQLGMGGGQGDMGIWHIMGTDGSLHPPPPHIQPLIGTSTVFYAGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UA09</accession>
    <name>A0A8C2UA09_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cytochrome P450 26A1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">CYP26A1</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>all-trans-retinoate + reduced [NADPH--hemoprotein reductase] + O2 = all-trans-(4S)-hydroxyretinoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51492"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:35291"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:134185"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:51493"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2UA09"/>
    <dbReference type="Ensembl" id="ENSCJPT00005033714.1">
        <property type="protein sequence ID" value="ENSCJPP00005024748.1"/>
        <property type="gene ID" value="ENSCJPG00005019490.1"/>
    </dbReference>
    <dbReference type="KEGG" id="cjo:107315945"/>
    <dbReference type="GeneTree" id="ENSGT00800000124060"/>
    <dbReference type="OrthoDB" id="1372046at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062183">
        <property type="term" value="F:all-trans retinoic acid 18-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008401">
        <property type="term" value="F:retinoic acid 4-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001972">
        <property type="term" value="F:retinoic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034653">
        <property type="term" value="P:retinoic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd20638">
        <property type="entry name" value="CYP26A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000041">
        <property type="entry name" value="Cytochrome P450 26A1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286">
        <property type="entry name" value="CYTOCHROME P450 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286:SF101">
        <property type="entry name" value="CYTOCHROME P450 26A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 16 17" id="KW-0349">Heme</keyword>
    <keyword evidence="10 16 17" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 16 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 17" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="16">
        <location>
            <position position="437"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005024748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="492" mass="55305" checksum="69D97E8E05437DA6" modified="2022-01-19" version="1">MGFYALVASALCTFLLPLLLFLAAVRLWDLYCASGRDPSCPLPLPPGTMGLPFFGETLQMVLQRRKFLQMKRRKYGFIYKTHLFGRPTVRVMGAENVRHILLGEHRLVSVQWPASVRTILGSGCLSNLHNGQHKHRKKVIMRAFSRDALQHYVPVIQEEVNACLAQWLGAGPCLLVYPEVKRLMFRIAMRILLGFQPRQAGPDGEQQLVEAFEEMIRNLFSLPIDVPFSGLYRGLRARNIIHAKIEENIRAKMARKEPEGGYKDALQLLMEHTQGNGEQLNMQELKESATELLFGGHETTASAATSLIAFLGLHHDVLQKVRKELQVKGLLSGPNQEKQLDMEVLEQLKYTGCVIKETLRLSPPVPGGFRIALKTLELNGYQIPKGWNVIYSICDTHDVADLFTDKDEFNPDRFMSPSPEDSSRFSFIPFGGGLRSCVGKEFAKVLLKIFTVELARSCDWQLLNGPPTMKTGPIVYPVDNLPAKFIGFSGQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UAC4</accession>
    <name>A0A8C2UAC4_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Cytidine deaminase</fullName>
            <ecNumber evidence="4 13">3.5.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 13">Cytidine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">CDA</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2 13">This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2'-deoxycytidine + H2O + H(+) = 2'-deoxyuridine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13433"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15698"/>
            <dbReference type="ChEBI" id="CHEBI:16450"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 13">
            <text>cytidine + H2O + H(+) = uridine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16069"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12 13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.5" evidence="4 13"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2UAC4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005032374.1">
        <property type="protein sequence ID" value="ENSCJPP00005023648.1"/>
        <property type="gene ID" value="ENSCJPG00005018722.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000000911"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004126">
        <property type="term" value="F:cytidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001882">
        <property type="term" value="F:nucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055086">
        <property type="term" value="P:nucleobase-containing small molecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072527">
        <property type="term" value="P:pyrimidine-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01283">
        <property type="entry name" value="cytidine_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000008">
        <property type="entry name" value="Cytidine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050202">
        <property type="entry name" value="Cyt/Deoxycyt_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006262">
        <property type="entry name" value="Cyt_deam_tetra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01354">
        <property type="entry name" value="cyt_deam_tetra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004064">
        <property type="entry name" value="PRK05578.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11644">
        <property type="entry name" value="CYTIDINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11644:SF2">
        <property type="entry name" value="CYTIDINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="14">
        <location>
            <begin position="15"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="56"/>
            <end position="62"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR606262-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR606262-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR606262-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005023648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="146" mass="16218" checksum="AA731126AB2888CD" modified="2022-01-19" version="1">FQAWDPHCSLPPQPKCLQLLLRRCREAKDCAYCPYSRFPVGAALLTANGEIFSGCNVENACYSLGMCAERAAILKAISEGHTRFKAMAIASNMSDFITPCGACRQVMREFGTDWDIYLTKPDGTYIVKTLRELLPLSFGPEDLQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UAF9</accession>
    <name>A0A8C2UAF9_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UAF9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005033955.1">
        <property type="protein sequence ID" value="ENSCJPP00005024928.1"/>
        <property type="gene ID" value="ENSCJPG00005019621.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00960000189067"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005024928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="104" mass="11363" checksum="CC4527AD7E83A738" modified="2022-01-19" version="1">MFIFEKHLTNQLQCSAVPSLTPLFPYSSSPPSSHAPFQCSVVYACVLTVLVFNKSEINVFEAKPALRPFQTPSHQRGCADGDRGSMQGLHSGLSPIGIVRGGWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UAP7</accession>
    <name>A0A8C2UAP7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Lysosome-associated membrane glycoprotein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LAMP2</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasmic vesicle</location>
            <location evidence="3">Autophagosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Lysosome membrane</location>
            <topology evidence="16">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the LAMP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2UAP7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005032513.1">
        <property type="protein sequence ID" value="ENSCJPP00005023780.1"/>
        <property type="gene ID" value="ENSCJPG00005018796.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182899"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044754">
        <property type="term" value="C:autolysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070062">
        <property type="term" value="C:extracellular exosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030670">
        <property type="term" value="C:phagocytic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031088">
        <property type="term" value="C:platelet dense granule membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008200">
        <property type="term" value="F:ion channel inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007042">
        <property type="term" value="P:lysosomal lumen acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035752">
        <property type="term" value="P:lysosomal lumen pH elevation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905146">
        <property type="term" value="P:lysosomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046716">
        <property type="term" value="P:muscle cell cellular homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160020">
        <property type="term" value="P:positive regulation of ferroptosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061740">
        <property type="term" value="P:protein targeting to lysosome involved in chaperone-mediated autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.110:FF:000011">
        <property type="entry name" value="Lysosome-associated membrane glycoprotein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.110:FF:000001">
        <property type="entry name" value="lysosome-associated membrane glycoprotein 2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.110">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048528">
        <property type="entry name" value="Lamp2-like_luminal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048524">
        <property type="entry name" value="Lamp2-like_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018134">
        <property type="entry name" value="LAMP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002000">
        <property type="entry name" value="Lysosome-assoc_membr_glycop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11506">
        <property type="entry name" value="LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11506:SF6">
        <property type="entry name" value="LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01299">
        <property type="entry name" value="Lamp2-like_luminal"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21222">
        <property type="entry name" value="Lamp2_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00336">
        <property type="entry name" value="LYSASSOCTDMP"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00310">
        <property type="entry name" value="LAMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51407">
        <property type="entry name" value="LAMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="11 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0967">Endosome</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 16" id="KW-0458">Lysosome</keyword>
    <keyword evidence="10 16 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 18" id="KW-0732">Signal</keyword>
    <keyword evidence="5 16 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034649246" description="Lysosome-associated membrane glycoprotein 2" evidence="18">
        <location>
            <begin position="29"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="390"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Lysosome-associated membrane glycoprotein 2-like luminal" evidence="19">
        <location>
            <begin position="33"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Lysosome-associated membrane glycoprotein 2-like luminal" evidence="19">
        <location>
            <begin position="229"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Lysosome-associated membrane glycoprotein 2-like transmembrane" evidence="20">
        <location>
            <begin position="392"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="154"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="346"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00074380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF01299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF21222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005023780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="425" mass="46673" checksum="1CE43B36C35045BB" modified="2022-01-19" version="1">TMAPRRPYGLELLSLLLLGTCGFFQSYAVEVDVKDASNVTCLYAQWMMKFLIKYETNSSDYKNTSLDLTPTVTHNGSICGSDTQAALLAVQFGDGHSWSVNFTKNNETYRAEFITFTYNTNDTAVFPDARRQGPVTIVVKDGMHPIQLNNVFVCHHTTSFEAENVTQIFWNVTMQPFVQNGTIGKKESRCHADTPTAAPTVLPTVANVTTASTTISPAPTATPKPVENPATGNYSLKTGNKTCLLATVGLQLNISQDKPLLINIDPKTTHADGTCGNTSATLKLNDGNRTLIDFTFIVNASTSVQKFYLKEVNVTLLNHLNGSVILSADNNNFSKWDASLGNSYMCRKEQTLEINEDLQVHTFNLWVQPFLVKENKFSIAQECSLDDDTILIPIVVGAALAGLIVIIVIAYIIGRRKSYAGYQTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UB95</accession>
    <name>A0A8C2UB95_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome c oxidase assembly factor COX14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">COX14</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2UB95"/>
    <dbReference type="Ensembl" id="ENSCJPT00005034276.1">
        <property type="protein sequence ID" value="ENSCJPP00005025177.1"/>
        <property type="gene ID" value="ENSCJPG00005019782.1"/>
    </dbReference>
    <dbReference type="KEGG" id="cjo:107325706"/>
    <dbReference type="GeneTree" id="ENSGT00390000002190"/>
    <dbReference type="OrthoDB" id="9928108at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome LGE22C19W28_E50C23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029208">
        <property type="entry name" value="COX14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36684">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36684:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14880">
        <property type="entry name" value="COX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005025177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="52" mass="5708" checksum="E45066C1CCA5229C" modified="2022-01-19" version="1">MVSGKQLADFGYKAFSGSMMLLTVYGGYLCGVRAYRLLQNRRARQASTGPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UDJ5</accession>
    <name>A0A8C2UDJ5_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAP30 binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">SAP30BP</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UDJ5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005036393.1">
        <property type="protein sequence ID" value="ENSCJPP00005026864.1"/>
        <property type="gene ID" value="ENSCJPG00005020873.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000007870"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045111">
        <property type="term" value="C:intermediate filament cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009615">
        <property type="term" value="P:response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012479">
        <property type="entry name" value="SAP30BP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13464:SF0">
        <property type="entry name" value="SAP30-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13464">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR PROTEIN HCNGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07818">
        <property type="entry name" value="HCNGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005026864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="288" mass="33161" checksum="A7D62D8515C1705B" modified="2022-01-19" version="1">MAAAKRSVLSSLAVYAEDSDPESDSETGTAGREKGGLVSVGYGEDDFSRLDGDEEGYEEEDDENSRQSEFSELEKRDPQELVASFSERVRNMSPDEIRIPPEPPGRCSNHLQDKIQKLYERKIKEGMDMNYIIQRKKEFRNPSIYEKLIQFCSIDELGTNYPKDMFDPHGWSEDSYYEALAKAQKIEMDKLEKAKKERTKVAVQGRERLRSTLHASFCLVLSFLARCFFQAVQMKLFALPYRSISLGCSFHWLCSCFVSIFKPELETWYAISQLQMRCSIENSLLLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UFC5</accession>
    <name>A0A8C2UFC5_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prostaglandin E synthase 2</fullName>
            <ecNumber evidence="3">5.3.99.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Microsomal prostaglandin E synthase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">PTGES2</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>prostaglandin H2 = (12S)-hydroxy-(5Z,8E,10E)-heptadecatrienoate + malonaldehyde</text>
            <dbReference type="Rhea" id="RHEA:48644"/>
            <dbReference type="ChEBI" id="CHEBI:57405"/>
            <dbReference type="ChEBI" id="CHEBI:90694"/>
            <dbReference type="ChEBI" id="CHEBI:566274"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:48645"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>prostaglandin H2 = prostaglandin E2</text>
            <dbReference type="Rhea" id="RHEA:12893"/>
            <dbReference type="ChEBI" id="CHEBI:57405"/>
            <dbReference type="ChEBI" id="CHEBI:606564"/>
            <dbReference type="EC" id="5.3.99.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:12894"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; prostaglandin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="18">Endomembrane system</location>
            <topology evidence="18">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EC" id="5.3.99.3" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2UFC5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005034826.1">
        <property type="protein sequence ID" value="ENSCJPP00005025616.1"/>
        <property type="gene ID" value="ENSCJPG00005020097.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000000224"/>
    <dbReference type="UniPathway" id="UPA00662"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050220">
        <property type="term" value="F:prostaglandin-E synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019371">
        <property type="term" value="P:cyclooxygenase pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:secretion"/>
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        <property type="project" value="Ensembl"/>
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        <property type="match status" value="1"/>
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    <dbReference type="CDD" id="cd03040">
        <property type="entry name" value="GST_N_mPGES2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000028">
        <property type="entry name" value="Prostaglandin E synthase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000114">
        <property type="entry name" value="Prostaglandin E synthase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.200.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011767">
        <property type="entry name" value="GLR_AS"/>
    </dbReference>
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        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034334">
        <property type="entry name" value="PGES2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034335">
        <property type="entry name" value="PGES2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12782">
        <property type="entry name" value="MICROSOMAL PROSTAGLANDIN E SYNTHASE-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12782:SF5">
        <property type="entry name" value="PROSTAGLANDIN E SYNTHASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01182">
        <property type="entry name" value="Prostaglandin_E_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01203">
        <property type="entry name" value="Prostaglandin_E_synthase_like1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00195">
        <property type="entry name" value="GLUTAREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0643">Prostaglandin biosynthesis</keyword>
    <keyword evidence="5" id="KW-0644">Prostaglandin metabolism</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="GST C-terminal" evidence="19">
        <location>
            <begin position="259"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005025616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="371" mass="41722" checksum="8C8938AEFB3A8378" modified="2022-01-19" version="1">MLGRVAVCPPRLTPALLPPLPSLKMAAAGRACRLTALLPPWRLRAPCRSLCSAARGAAAGGGRLLLGAAFALGGGAGLCMAARQRLTEHKAAELPAGNLQLTLYQYKTCPFCSKVRAFLDYHGLPYEIVEVNPIMRKEIKFSAYRKVPILLADAGSPLQLNDSSVIISAIKTYLISNLEEIVSFYPPMKTVTEQGKEVLEYGNKYWLMLDEKETKRVYPVKEVRVEEMQWRKWADDWLVHLISPNVYRTPKEALASFDYIVREGKFGTLEGFIAKYLGAIAMFFVSKRLKKRHHLRDDVRQDLYEAVDKWVKAIGKNRLFMGGSQPNLADLAVYGVLRVMEGLEAFDDMMVHTKIQPWYQRMEEAIQRAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UFP5</accession>
    <name>A0A8C2UFP5_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Density-regulated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">DENR</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the DENR family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2UFP5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005035011.1">
        <property type="protein sequence ID" value="ENSCJPP00005025760.1"/>
        <property type="gene ID" value="ENSCJPG00005020188.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000014349"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0075522">
        <property type="term" value="P:IRES-dependent viral translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032790">
        <property type="term" value="P:ribosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002188">
        <property type="term" value="P:translation reinitiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11607">
        <property type="entry name" value="DENR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.780.10:FF:000004">
        <property type="entry name" value="density-regulated protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050318">
        <property type="entry name" value="DENR/SUI1_TIF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046447">
        <property type="entry name" value="DENR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005873">
        <property type="entry name" value="DENR_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048517">
        <property type="entry name" value="DENR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01159">
        <property type="entry name" value="DRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12789:SF0">
        <property type="entry name" value="DENSITY-REGULATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12789">
        <property type="entry name" value="DENSITY-REGULATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21023">
        <property type="entry name" value="DENR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUI1" evidence="6">
        <location>
            <begin position="103"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="56"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="83"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005025760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="186" mass="20895" checksum="254AD6AB711E954A" modified="2022-01-19" version="1">MAADVAEPVAPDYRGDIRSGARSDADYPLRYCEYMPDVTKCRQWLEKNFPDEFAKLTVENSPKQEAGVGEGQGTAGEEEEKKKQKRGGRGQIKQKKKTVPQKVTIAKIPRAKKKYVTRVCGLATFEIDLKEAQRFFAQKFSCGASVTGEDEIIIQGDFTDDIIDVIQEKWPEVDDDSIEDLGEVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UFZ9</accession>
    <name>A0A8C2UFZ9_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein regulator of cytokinesis 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">PRC1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UFZ9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005036896.1">
        <property type="protein sequence ID" value="ENSCJPP00005027267.1"/>
        <property type="gene ID" value="ENSCJPG00005021159.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000009453"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070938">
        <property type="term" value="C:contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045171">
        <property type="term" value="C:intercellular bridge"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019894">
        <property type="term" value="F:kinesin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051256">
        <property type="term" value="P:mitotic spindle midzone assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032465">
        <property type="term" value="P:regulation of cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007145">
        <property type="entry name" value="MAP65_Ase1_PRC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19321:SF1">
        <property type="entry name" value="PROTEIN REGULATOR OF CYTOKINESIS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19321">
        <property type="entry name" value="PROTEIN REGULATOR OF CYTOKINESIS 1 PRC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03999">
        <property type="entry name" value="MAP65_ASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="469"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="511"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="47"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="100"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="215"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="385"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="471"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="489"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="550"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005027267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="614" mass="70784" checksum="F5E3847333E151CF" modified="2022-01-19" version="1">MRRSEVLAAEAVTCLNRALSALRDIWEEIGIPEELRLERTGAVKRHIKNLLDMMVAEEERLREQMLQTVAVYRKELDGLCAELHAEPFQTQEGSTILQMVNELRARVEVLLKQKKDRKQELKALQEQDKNLCDILCVSLFSIDDGAVPSLDELDRYRRHVASLSAEKERRQEEFVSIKRQVVQCMAELEHSPDTSFERDVVCEDEEAFCLSTDNIANLQSLLQQLEARRALNEAMCAELRSRITELWERLQVPEEERESFAVHMTGSKAKTREALKLEVERLEELKLQNMKSVVQAIRTELAEYWDKCFYSQEQRDAFSPYYDEEYTEALLQLHDTEVGKMKSYYETHKELFEAVHKWEENWKLFLELERKAADPNRLANRGGSLLKEEKQRAKLQKTLSKLQEELESRIQAWEQERKEPFLVKGQQFMEYVTEQWQLYRMEKEKEKQERQLKKSRQIETEMMYGSTPRTPIKRRVLGPHTPGKVRKLNGTSLSTATPNSTIRSAFGATLFHSPTSRLPPSGGKLGQARTPNRVAAKAPRPGHRERNKENLSQLNGTTLSGGCSPAVPAQRNHSVNSVASTYSEFARELSKASSCRLLGFPSVPIISAVFQSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UJ79</accession>
    <name>A0A8C2UJ79_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">KIF2B</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-13 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015735684.1">
        <property type="nucleotide sequence ID" value="XM_015880198.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UJ79"/>
    <dbReference type="Ensembl" id="ENSCJPT00005037343.1">
        <property type="protein sequence ID" value="ENSCJPP00005027660.1"/>
        <property type="gene ID" value="ENSCJPG00005021414.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107322297"/>
    <dbReference type="KEGG" id="cjo:107322297"/>
    <dbReference type="CTD" id="84643"/>
    <dbReference type="GeneTree" id="ENSGT00940000165325"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007019">
        <property type="term" value="P:microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01367">
        <property type="entry name" value="KISc_KIF2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000012">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054473">
        <property type="entry name" value="KIF2A-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47971:SF24">
        <property type="entry name" value="KINESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47971">
        <property type="entry name" value="KINESIN-RELATED PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22923">
        <property type="entry name" value="KIF2A-like_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 15" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10 14 15" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="17">
        <location>
            <begin position="187"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="624"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="277"/>
            <end position="284"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00061030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005027660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="643" mass="73058" checksum="C024E9F264246A87" modified="2022-01-19" version="1">MNSMASKFGLIQLGSCVEIKHSSGRPYQAVVTKLHESTSSVTVEWLERGTSKTKQVDLQVIFDLNPHLVPRTRSASGAETSLSARGNWSPVSEMWTQPIKAEKCWDSRSSVVARTQSTTRWMSPGMWQKEKPPKQQECQQLDVQEKPVQKDNTSLRARTDIVAMIQECRNHLNGKTQWTSMPCQPRRISVCIRKRPLNQREAELNDTDVVTVSCQGMVIVHEAKQKLDLTQYLNNQVFRFDHAFDGHAANELVYRHTAQPLVDIIFQGGMATCFAYGQTGSGKTHTMRGNITSKGIYVLVAEDVFRRLQYPNYQKLELWVYGAFFEIYRGKVFDLLNRKKRLRVLENGQKQIQVVGLCEEEVTCVEDVIRLIETGSNCRMAGQTSANTQSSRSHAIFQIILKRRGQLYAKFSLIDLAGNERGADITTADKQTRLEGADINKSLLALKECIRALGHNQAHTPFRASKLTQVLRDSLIGENSYTCMIATVSPGIRSCEHTLNTLRYANRVKELVVDLNSLEQPFQVASSLPQQQQFGVQADKEVLSKALTLNGKGETLKKRKEINEETITEKHQKSLRWLKELLQTAERTVRNVDIYAAQFESFLDQEIGILTEIREKVRLSPRRIQNKEEQDKNQSCTKRSHAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UK33</accession>
    <name>A0A8C2UK33_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">FAM20B glycosaminoglycan xylosylkinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">FAM20B</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAM20 family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_015869687.2"/>
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        <property type="nucleotide sequence ID" value="XM_032446416.1"/>
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    <dbReference type="AlphaFoldDB" id="A0A8C2UK33"/>
    <dbReference type="Ensembl" id="ENSCJPT00005037240.1">
        <property type="protein sequence ID" value="ENSCJPP00005027562.1"/>
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    <dbReference type="GeneID" id="107317235"/>
    <dbReference type="KEGG" id="cjo:107317235"/>
    <dbReference type="CTD" id="9917"/>
    <dbReference type="GeneTree" id="ENSGT00950000182951"/>
    <dbReference type="OrthoDB" id="8583677at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 8"/>
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    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10470">
        <property type="entry name" value="FAM20B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024869">
        <property type="entry name" value="FAM20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009581">
        <property type="entry name" value="FAM20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12450">
        <property type="entry name" value="DENTIN MATRIX PROTEIN 4 PROTEIN FAM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12450:SF14">
        <property type="entry name" value="GLYCOSAMINOGLYCAN XYLOSYLKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06702">
        <property type="entry name" value="Fam20C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM20 C-terminal" evidence="9">
        <location>
            <begin position="189"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="222"/>
            <end position="225"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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        <location>
            <position position="309"/>
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        <ligand>
            <name>ATP</name>
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        <ligand>
            <name>Mn(2+)</name>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006557"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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        <source>
            <dbReference type="PIRSR" id="PIRSR624869-1"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF06702"/>
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    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005027562.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="409" mass="46549" checksum="3BED862448C52F86" modified="2022-01-19" version="1">MKLKQRVVLLAILLVIFIFTKVFLIDNLDTSAANREDQRAFHRMMASLRVELDPRLEHTLQSPWEIAAQWVVPREVYPEETPELGAVMHAMSTKKIIKADVGYKGTQLKALLILEGGQKVVFKPKRYARDYVVEGEPYAGYDRHNAEVAAFHLDRILGFRRAPLVVGRFVNLRTEIKPVATEQLLGTFMTVGNSTCFYGKCYYCRETEPACADGDIMEGSVTLWLPDVWPLQKHRHPWGRTYREGKLARWEYDESYCDAVKKTSPYDSGPRLLDIIDTAIFDYLIGNADRHHYESFQDDEGASMLILLDNAKSFGNPALDERSILAPLYQCCIIRVSTWNRLNYLKNGVLKSALKTAMSHDPISPVLSDPHLDALDQRLLSILATVKQCTDQFGPDVVLVEDRMTLSHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y612</accession>
    <name>A0A8C2Y612_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
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            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
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    <dbReference type="AlphaFoldDB" id="A0A8C2Y612"/>
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        <property type="protein sequence ID" value="ENSCJPP00005002534.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Stress-induced phosphoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
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        <property type="entry name" value="TPR-like_helical_dom_sf"/>
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        <property type="entry name" value="TPR_rpt"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904">
        <property type="entry name" value="TPR REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TPR_8"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="12"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005002534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="90" mass="10134" checksum="026FC02B45535B46" modified="2022-01-19" version="1">YTAAIALDANNHVLYSNRSAAYAKQGDYSRALADACRTIELRPDWAKGYSRKAAALEFLNRFEEAKATYEEGLKHEPSNAQLREGLHNME</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y722</accession>
    <name>A0A8C2Y722_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">5'-nucleotidase, cytosolic IA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">NT5C1A</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015739226.1">
        <property type="nucleotide sequence ID" value="XM_015883740.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y722"/>
    <dbReference type="Ensembl" id="ENSCJPT00005008524.1">
        <property type="protein sequence ID" value="ENSCJPP00005005204.1"/>
        <property type="gene ID" value="ENSCJPG00005005035.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107324057"/>
    <dbReference type="KEGG" id="cjo:107324057"/>
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    <dbReference type="GeneTree" id="ENSGT00390000017767"/>
    <dbReference type="OrthoDB" id="9994138at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="F:magnesium ion binding"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="P:adenosine metabolic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000255">
        <property type="term" value="P:allantoin metabolic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006196">
        <property type="term" value="P:AMP catabolic process"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:dGMP catabolic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:IMP catabolic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010394">
        <property type="entry name" value="5-nucleotidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31367">
        <property type="entry name" value="CYTOSOLIC 5'-NUCLEOTIDASE 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31367:SF2">
        <property type="entry name" value="CYTOSOLIC 5'-NUCLEOTIDASE 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06189">
        <property type="entry name" value="5-nucleotidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005005204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="407" mass="45091" checksum="0930B4A6911054D3" modified="2022-01-19" version="1">MGLGAAGRGGLSPEEVKPRPGGMKPRSFMGCRIKAFRRRELPVRTERCAMEPPGTAGAPGAAGRPWDEAKAFYDNLTPKKKPKSPKPENAITIAVSSRALFRMEEEQKIYNEQGVEAYVKYQLDHENEPFLPGAAFPFVKALEAVNTQLRELYPDSEELFDIVLMTNNHAQVGVRLINSINHYDLFIERFCMTGGNSPIGYLKAYHTNLYLSSDAEKVSGAIEEGIAAATIFSPSKDLQVSEKQLRVAFDGDAVLFSDESEQIVKAHGLDMFFEHEKAHENNPLAQGPLKGFLEALGKLQKKFYSKGLRMECPIRTYLVTARSAASSGARALKTLRSWGLETDEALFLAGAPKGPLLKKIRPHIFFDDQMFHVEGAKEMGTVAAHVPYGVAQKHKQQLQEKPPQNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y871</accession>
    <name>A0A8C2Y871_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Beta-galactosidase</fullName>
            <ecNumber evidence="5">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">GLB1L2</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="5"/>
    <dbReference type="RefSeq" id="XP_015739390.1">
        <property type="nucleotide sequence ID" value="XM_015883904.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y871"/>
    <dbReference type="Ensembl" id="ENSCJPT00005011138.1">
        <property type="protein sequence ID" value="ENSCJPP00005007187.1"/>
        <property type="gene ID" value="ENSCJPG00005006627.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107324161"/>
    <dbReference type="CTD" id="89944"/>
    <dbReference type="GeneTree" id="ENSGT00950000182942"/>
    <dbReference type="OrthoDB" id="1657402at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000049">
        <property type="entry name" value="Beta-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000036">
        <property type="entry name" value="Beta-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026283">
        <property type="entry name" value="B-gal_1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048912">
        <property type="entry name" value="BetaGal1-like_ABD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048913">
        <property type="entry name" value="BetaGal_gal-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019801">
        <property type="entry name" value="Glyco_hydro_35_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="BETA-GALACTOSIDASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21317">
        <property type="entry name" value="BetaGal_ABD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21467">
        <property type="entry name" value="BetaGal_gal-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006336">
        <property type="entry name" value="B-gal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00742">
        <property type="entry name" value="GLHYDRLASE35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01182">
        <property type="entry name" value="GLYCOSYL_HYDROL_F35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase 35 catalytic" evidence="7">
        <location>
            <begin position="52"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase 1-like first all-beta" evidence="8">
        <location>
            <begin position="422"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase galactose-binding" evidence="9">
        <location>
            <begin position="548"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR006336-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005007187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="636" mass="72932" checksum="CA279BA279A9B3CC" modified="2022-01-19" version="1">MWPCGGRRQRRFGGVAMLLLVLWLLARRFNWSELVPVRLWGRTLGLQTKHSQFLLEGMPFRIFGGSMHYFRVPREYWEDRMLKMKACGLNTLTTYVPWNLHEQTRGKFDFSENLDLEAFLSLAAKNGLWVILRPGPYICSEWDLGGLPSWLLQDPEMQLRTTYKGFTEAVDAYFDRLMPIVVPLQYKRGGPIIAVQVENEYGSYAKDSNYMAYVKMALLSRGIVELLMTSDNKNGLSYGLVEGALATVNFQKLEPGVLKYLDKIQRDQPMMVMEYWTGWFDNWGGPHCVFDADEMVNTVASILRLGASINLYMFHGGTNFGFMNGALKTDEYKSDVTSYDYDAVLTEAGDYTSKFFKLRQLFSTIIGQPLPLPPMIESKASYGAILLHQYISLWDVLPSLVQPIKSEFPVNMENLQLNDSSGQSYGYVLYEVVIFGGGQLHSRDHVRDRAQVFINTMYVGELDYNTVELSLPEGQGFRQLRLLVENRGRVNYGLSLNEQRKGLIGDIFLNKTPLRNFRIYSLEMKPDFLKSLQHAGGWSAVPDYFVGPAFFRGKLWIEHQPQDTFLKLQGWEKGVVFVNGHNLGRYWKIGPQETLYLPGPWLRKGSNEIIIFEERAAGRIIQSVDIPYLGRTQYVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y8E7</accession>
    <name>A0A8C2Y8E7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Sentrin-specific protease 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">SUMO-1-specific protease 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Sentrin/SUMO-specific protease SENP6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">SENP6</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Also desumoylates RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Interacts with RXRA. Forms a complex with KAT5-TIP60 and UBE2I in response to UV irradiation. Interacts with RPA1 to maintain it in hyposumoylated state during S phase preventing DNA repair initiation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase C48 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015714530.1">
        <property type="nucleotide sequence ID" value="XM_015859044.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y8E7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005011765.1">
        <property type="protein sequence ID" value="ENSCJPP00005007631.1"/>
        <property type="gene ID" value="ENSCJPG00005006979.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107312029"/>
    <dbReference type="CTD" id="26054"/>
    <dbReference type="GeneTree" id="ENSGT00940000155724"/>
    <dbReference type="OrthoDB" id="442460at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070139">
        <property type="term" value="F:SUMO-specific endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016926">
        <property type="term" value="P:protein desumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090234">
        <property type="term" value="P:regulation of kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090169">
        <property type="term" value="P:regulation of spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.20:FF:000005">
        <property type="entry name" value="sentrin-specific protease 6 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.20:FF:000010">
        <property type="entry name" value="sentrin-specific protease 6 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.395.10:FF:000027">
        <property type="entry name" value="SUMO-specific peptidase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051947">
        <property type="entry name" value="Sentrin-specific_protease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46896">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46896:SF1">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="18">
        <location>
            <begin position="700"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="179"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="272"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="350"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="637"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="828"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="903"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1115"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="189"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="350"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="386"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="637"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="828"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="917"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1119"/>
            <end position="1141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00058874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00062458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00073899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00077364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00079020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005007631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1149" mass="129320" checksum="61959E46CEC911FF" modified="2022-01-19" version="1">MFCSPVSKSASFRKLLPTSLDRSQSKRDGGFKNNWSFDHAEESEGDAEKDEANLLSIDDSDGPFSPNEERKSFRCRPGAVGIGGDSIKTYARRGKAASLRPFKGNAIGLNMMGNSKKLSENAQNVSCPVTVVHGRRFHHAHAQTTVVKTAAQSNLDRKERKEYPPQLQKVEADHIRLPRPQGLDNVMENTEESESESESEIKRKVQQKRHCNSFQSDLSLSSAKKGLTQLKLLEPIEYSTDCPNCGRANENQTKCRHCENVSLKDLHRVSRQAGTLSESVGPLSRSSIHQNSVGQKSSGTGFNTKKFYSSAVGKGPADILLGNEVVGHSLLRQNGKVGLLTGTKNAKITGNLRQRNTRPSELNDPIVLSSDDDEEEDSGSTRRMESISPRPADSARSSPAPSTGKVEAALKENSCGIEQRIGSITTDTEIAVTLPRKARMKDQFGNIVSNTPIKRRKLISQEIVTEAVPPLHYQNSCESVILNCRSIRIGTLRRMVVEPVIFCLDYIKIRLESQEESDSDVREINLKTSELTKCEWCSVRKLPVVFLQTVPSTCSSLREQLKMSKDNVWYECKGDSQEEQYIILIFETGLDPHANSIFEKIITDIGIRNNISDFFVKISFEEANGRLVAFTKCLEDNSKGSPSHRENKFKNVAPDSKVQPRNKQLPYFDDEEEIGEPHTVFIGPIEKLIVYPPPPAKGGISVTNEDLHCLNEGEFLNDVIIDFYLKYLVLEKLKKEDADRIHVFSSFFYKRLNQRERRSIHETSNLSIQQKRHGRVKTWTRHVDIFEKDFIFVPLNEAAHWFLAVICFPGLEKPKYEPNPHYHENAATQIKSSSSDGESNTPSPLPNELDAQNSPSKSTAKKTLTKKYNTALTDSNTETQDSESSCCRRSPCRVKSGFKKLNQIDSDVEEPNTVESASHRLDHRTPDENGIQGEFTTANQSMDGLHKIRLNYSEDSADGGKLNEDELIDFSEDQDNQEDSSDDGGLLDDSCNSDMGQWHLKPTICKQPCILLMDSLRGPSRSNVVKTLREYLEVEWEVRKGNKRSFSKDVVKGSNPKVPQQNNFSDCGVYILQYVESFFENPILSFELPMNLTDWFPRPRMKTKREEIRNIILKLQEQQNKDKKGQKDPASAERSLQDKTEQLLNSGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y8U8</accession>
    <name>A0A8C2Y8U8_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Matrix AAA peptidase interacting protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC107306886</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y8U8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005012966.1">
        <property type="protein sequence ID" value="ENSCJPP00005008568.1"/>
        <property type="gene ID" value="ENSCJPG00005007642.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000004145"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032979">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane from matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13333">
        <property type="entry name" value="M-AAA PROTEASE-INTERACTING PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13333:SF5">
        <property type="entry name" value="M-AAA PROTEASE-INTERACTING PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005008568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="266" mass="29746" checksum="04DD1DAF4C2EEA2A" modified="2022-01-19" version="1">MSAPHGRCPSVRRERRTEQNRSPTPAAFPAERCPLGRTGAGRRAAMLALRAAPRRARCLTGALLVPGAARAAPLLRRVPAPPLPGLVPTLSSARFTSSGPQGDGPQRRVVVVRITNPLAWLRTRFYYLLIRLYFDSEFSIEEFTRGAKQAFSVVSQLLSQRKLDLLDGLVSAEVLQMLKEKISSLSENHRDALAADMDAIMYTTEGDVRIYYDDDGRKFVSILMRFWYLNGANLPDEVPGETKVFQIVFGDENTKEKRHILTANYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y8Z1</accession>
    <name>A0A8C2Y8Z1_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">SIM bHLH transcription factor 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">SIM2</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015737804.1">
        <property type="nucleotide sequence ID" value="XM_015882318.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y8Z1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005013267.1">
        <property type="protein sequence ID" value="ENSCJPP00005008796.1"/>
        <property type="gene ID" value="ENSCJPG00005007820.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107323335"/>
    <dbReference type="CTD" id="6493"/>
    <dbReference type="GeneTree" id="ENSGT00940000159985"/>
    <dbReference type="OrthoDB" id="6021714at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009880">
        <property type="term" value="P:embryonic pattern specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030324">
        <property type="term" value="P:lung development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19739">
        <property type="entry name" value="bHLH-PAS_SIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000017">
        <property type="entry name" value="SIM bHLH transcription factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000047">
        <property type="entry name" value="SIM bHLH transcription factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000007">
        <property type="entry name" value="single-minded homolog 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010578">
        <property type="entry name" value="SIM_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23043">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23043:SF19">
        <property type="entry name" value="SINGLE-MINDED HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23171">
        <property type="entry name" value="bHLH_HIF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06621">
        <property type="entry name" value="SIM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51302">
        <property type="entry name" value="SIM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4" id="KW-0221">Differentiation</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="11">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="10">
        <location>
            <begin position="77"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="10">
        <location>
            <begin position="233"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Single-minded C-terminal" evidence="12">
        <location>
            <begin position="336"/>
            <end position="767"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005008796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="767" mass="86752" checksum="70C7E2F9436874ED" modified="2022-01-19" version="1">MKEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGLGDAWGQPSRIGPLDNVAKELGSHLLQTLDGFVFVVASDGKIMYISETASVHLGLSQVELTGNSIYEYIHPSDHDEMTAVLTAHQPLHPHLLQEYEIERSFFLRMKCVLAKRNAGLTCSGYKVIHCSGYLKIRQYMLDMSLYDSCYQIVGLVAVGQSLPPSAITEIKLHSNMFMFRASLDLKLIFLDSRVTELTGYEPQDLIEKTLYHHVHGCDVFHLRYAHHLLLVKGQVTTKYYRLLSKQGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLTDIEYKELQLSLDQVTISKSQFSCRNSVSTSQETRKIVKPKSNKMKAKLRTTPYPQQQYSSFQTDKLECSQVGNWRSSPAVNAATIQEQNFHSENSELLYAPSYSLPFSYHYGHFPVDSHVFSSKKQMLPPKFGQSQGAPCEVARFFLSTLQTNGECQWHYANSLVPNSQSPSKNLPEQPVNFIRHNLGQSYEVPVSNRRYNQDALADNFTSCTAPMAGSRYKEEIYDSSILKPNKIENRIQTPHHLIKEENKLAFNRDLQEKMSINESSFSNSVANSLLPKSECFQSKALGQLSHLLPVPAVYEQTRRICMKEPKYGHISHHATSLNELDSDERMTVKLDHDSESEHVMDVRPSGQVPFVLLNYHHVLAKHGTFQTSSCTATGHVGENYGYNSEEVNTFMYKNQSPSSASSPETHKETTLPHYIGTSVIIANGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YA93</accession>
    <name>A0A8C2YA93_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Sin3A associated protein 30</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">SAP30</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAP30 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015717277.1">
        <property type="nucleotide sequence ID" value="XM_015861791.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YA93"/>
    <dbReference type="Ensembl" id="ENSCJPT00005016878.1">
        <property type="protein sequence ID" value="ENSCJPP00005011545.1"/>
        <property type="gene ID" value="ENSCJPG00005009922.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107313482"/>
    <dbReference type="KEGG" id="cjo:107313482"/>
    <dbReference type="CTD" id="8819"/>
    <dbReference type="GeneTree" id="ENSGT00390000006633"/>
    <dbReference type="OrthoDB" id="510958at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035914">
        <property type="term" value="P:skeletal muscle cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1800.30:FF:000001">
        <property type="entry name" value="Histone deacetylase complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024145">
        <property type="entry name" value="His_deAcase_SAP30/SAP30L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038291">
        <property type="entry name" value="SAP30_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025718">
        <property type="entry name" value="SAP30_Sin3-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025717">
        <property type="entry name" value="SAP30_zn-finger"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13286:SF7">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT SAP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13286">
        <property type="entry name" value="SAP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13867">
        <property type="entry name" value="SAP30_Sin3_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13866">
        <property type="entry name" value="zf-SAP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Histone deacetylase complex subunit SAP30 zinc-finger" evidence="12">
        <location>
            <begin position="58"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Histone deacetylase complex subunit SAP30 Sin3 binding" evidence="13">
        <location>
            <begin position="146"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="13"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005011545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="213" mass="22852" checksum="6AE079B8319760F5" modified="2022-01-19" version="1">MNGFAPEELPQRGADPAVAAAGAVSGAGSGAEVPAGSAPPGLAVGAAGAAGAGGPGAGQLCCLREEGERCGRAAGNASFSKRIQKSISQKKVKIELDKSARHLYICDFHKNLIQSVRNRRKRKGSDDDGDSPVQDIDTPEVDLYQLQVNTLRRYKRHFKLQTRPGLNKAQLVEIIGCHFRTIPVNEKDTLAYFIYSVKNDKNKPDLKMDSGVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YBJ6</accession>
    <name>A0A8C2YBJ6_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Eukaryotic translation initiation factor 2 alpha kinase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">EIF2AK2</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015713050.1">
        <property type="nucleotide sequence ID" value="XM_015857564.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YBJ6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005020722.1">
        <property type="protein sequence ID" value="ENSCJPP00005014575.1"/>
        <property type="gene ID" value="ENSCJPG00005012148.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107311230"/>
    <dbReference type="KEGG" id="cjo:107311230"/>
    <dbReference type="CTD" id="5610"/>
    <dbReference type="GeneTree" id="ENSGT00940000160736"/>
    <dbReference type="OrthoDB" id="341578at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004694">
        <property type="term" value="F:eukaryotic translation initiation factor 2alpha kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140374">
        <property type="term" value="P:antiviral innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033689">
        <property type="term" value="P:negative regulation of osteoblast proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045071">
        <property type="term" value="P:negative regulation of viral genome replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032722">
        <property type="term" value="P:positive regulation of chemokine production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901224">
        <property type="term" value="P:positive regulation of non-canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032874">
        <property type="term" value="P:positive regulation of stress-activated MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902036">
        <property type="term" value="P:regulation of hematopoietic stem cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902033">
        <property type="term" value="P:regulation of hematopoietic stem cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900225">
        <property type="term" value="P:regulation of NLRP3 inflammasome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035455">
        <property type="term" value="P:response to interferon-alpha"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006413">
        <property type="term" value="P:translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF163">
        <property type="entry name" value="INTERFERON-INDUCED, DOUBLE-STRANDED RNA-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DRBM" evidence="10">
        <location>
            <begin position="4"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="10">
        <location>
            <begin position="99"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="279"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="171"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="171"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="185"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005014575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="549" mass="62699" checksum="C2FB6D871ADC5C5F" modified="2022-01-19" version="1">MDRKYMSLVNNYCQKRNATLDYVEVEMKGLPHDPEFTFMVKIDGEEYGTGIAKSKKEAKAAAAKSTWDMIEPQQSSASNVHVPDPVASPPPVDVPPPCDYVSKLNDYAQKTSQLVDYSNVKRTGDAHAPIYSCSCKISGHVYGNGTGNTLDAAKQAAAEEAYKALKEQESLSLKSEDSNHRFHELSNSSRKQSPSESWGITFRDSATSLAEKVKDISLSEEPPNSRRNVPASALKSKRVLAPNFDNARNEQKKVLSNICRNRSEADDEYTVDERFRREYENIEPIGKGGFGNVFKATSRVDERTYAVKRVELIRNVKREVKELAKLGHENIVRYYYSWEGTDHMIYPDASKNSEIPVPCLFIQMELCEQGPLDNWIENNRQNQNYHMMAQDKFLQILKGVDYIHSENLIHRDLKPQNIFLSREGKIKIGDFGLVTSVTYDTLTKNRGTRSYMAPEQFGDRYGKEVDIYALGLIWFEILYRLVSHHEKNKVWQDVREGHLPLDFTKQFKIQVPIIKKMLSEDPSKRCSASQLLDILKSRDKDNSQKPYSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YCT6</accession>
    <name>A0A8C2YCT6_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 23">Calreticulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="28" type="primary">CALR3</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="28" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="28" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell surface</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="22">Cytoplasmic vesicle</location>
            <location evidence="22">Secretory vesicle</location>
            <location evidence="22">Cortical granule</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 23">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Sarcoplasmic reticulum lumen</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
            <location evidence="3">Extracellular space</location>
            <location evidence="3">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 23 26">Belongs to the calreticulin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2YCT6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005023733.1">
        <property type="protein sequence ID" value="ENSCJPP00005016954.1"/>
        <property type="gene ID" value="ENSCJPG00005013885.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182915"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060473">
        <property type="term" value="C:cortical granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033018">
        <property type="term" value="C:sarcoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.250.10:FF:000002">
        <property type="entry name" value="Calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000113">
        <property type="entry name" value="Calreticulin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000122">
        <property type="entry name" value="Calreticulin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.250.10">
        <property type="entry name" value="Calreticulin/calnexin, P domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001580">
        <property type="entry name" value="Calret/calnex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018124">
        <property type="entry name" value="Calret/calnex_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009169">
        <property type="entry name" value="Calreticulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009033">
        <property type="entry name" value="Calreticulin/calnexin_P_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073">
        <property type="entry name" value="CALRETICULIN AND CALNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073:SF3">
        <property type="entry name" value="CALRETICULIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00262">
        <property type="entry name" value="Calreticulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002356">
        <property type="entry name" value="Calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00626">
        <property type="entry name" value="CALRETICULIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63887">
        <property type="entry name" value="P-domain of calnexin/calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00803">
        <property type="entry name" value="CALRETICULIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00804">
        <property type="entry name" value="CALRETICULIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00805">
        <property type="entry name" value="CALRETICULIN_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18" id="KW-0007">Acetylation</keyword>
    <keyword evidence="17" id="KW-0106">Calcium</keyword>
    <keyword evidence="20 23 26" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="21" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="19 25" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15 23 26" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="13" id="KW-0430">Lectin</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0964">Secreted</keyword>
    <keyword evidence="12 26" id="KW-0732">Signal</keyword>
    <keyword evidence="16" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="26">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034922803" description="Calreticulin" evidence="26">
        <location>
            <begin position="29"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="220"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="352"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="27">
        <location>
            <begin position="357"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>an alpha-D-glucoside</name>
            <dbReference type="ChEBI" id="CHEBI:22390"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>an alpha-D-glucoside</name>
            <dbReference type="ChEBI" id="CHEBI:22390"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>an alpha-D-glucoside</name>
            <dbReference type="ChEBI" id="CHEBI:22390"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>an alpha-D-glucoside</name>
            <dbReference type="ChEBI" id="CHEBI:22390"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>an alpha-D-glucoside</name>
            <dbReference type="ChEBI" id="CHEBI:22390"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="114"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00015837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00037865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRNR" id="PIRNR002356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRSR" id="PIRSR002356-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PIRSR" id="PIRSR002356-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="RuleBase" id="RU362126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005016954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="403" mass="46489" checksum="7237B7D6AFD60A79" modified="2022-01-19" version="1">MAAGPAARGLLLLGAVLLLGAVLGAARAVVYFQEQFLDGGGWRQRWVSSESRPDLGTFHLSAGKFYGDPVRDRGLQTRENSKFYAISSRFKPFSNKGKTLVIQYTVKHEQKIDCGGGYIKIFSSDLDQKNLSGASPYYIMFGPDICGSETKKVHVILNYKNKLHPIKKPIRCKVDGYTHLYTLIIRPDQTYEVKIDNEVAALGNLEDDLDFLPPKKINDPAVKKPSDWDDRAHIADPNDIKPEHWDEPEYIMDTSDEKPEDWDHTVHGEWRYPMVKNPLYKGEWKPRQIDNPNYRGVWPHPQIDNPHYSPDFNIYSYENIGAIGLDIWQVSSGTIFDNFLITDDEDYAEDFGDETWGETKDPEKEMNIRQAEEEQQRKRVAEEEHFDQWFKKKQEGEKRISNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YCU0</accession>
    <name>A0A8C2YCU0_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Heat shock protein family B (small) member 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">HSPB2</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015739319.1">
        <property type="nucleotide sequence ID" value="XM_015883833.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YCU0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005023759.1">
        <property type="protein sequence ID" value="ENSCJPP00005016978.1"/>
        <property type="gene ID" value="ENSCJPG00005013908.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107324123"/>
    <dbReference type="KEGG" id="cjo:107324123"/>
    <dbReference type="CTD" id="3316"/>
    <dbReference type="GeneTree" id="ENSGT00940000161288"/>
    <dbReference type="OrthoDB" id="1431247at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005212">
        <property type="term" value="F:structural constituent of eye lens"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007525">
        <property type="term" value="P:somatic muscle development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd06476">
        <property type="entry name" value="ACD_HspB2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001436">
        <property type="entry name" value="Alpha-crystallin/sHSP_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003090">
        <property type="entry name" value="Alpha-crystallin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640:SF27">
        <property type="entry name" value="HEAT SHOCK PROTEIN BETA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640">
        <property type="entry name" value="HEAT SHOCK PROTEIN HSP-12.2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00525">
        <property type="entry name" value="Crystallin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00299">
        <property type="entry name" value="ACRYSTALLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="112"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005016978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="240" mass="26936" checksum="411538B7656EB85C" modified="2022-01-19" version="1">MRSCPRHPGEAARGLCAQLFWSVFLSHTPPCGIHPTKTLQSAAFALRGSESLDRPVPQLAMAARTVPHAYPMSSEYEFANPSKIYDQNFGEGVSPCEILAPALYHGYYIRPRINKQLDRGTSEVSLNDHKYQVFLDVCHFLPDELTVRTVDNLLEVVGQHPQRADRHGFISREFTRTYILPLDVDPLLMRATLSHDGILSIVAPRTGKEVKARIIKVKIIQEDTTGQEELSEEGKGREES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YDB6</accession>
    <name>A0A8C2YDB6_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C-type lectin domain family 3 member A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">CLEC3A</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015729671.1">
        <property type="nucleotide sequence ID" value="XM_015874185.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YDB6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005025120.1">
        <property type="protein sequence ID" value="ENSCJPP00005018058.1"/>
        <property type="gene ID" value="ENSCJPG00005014683.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107319418"/>
    <dbReference type="KEGG" id="cjo:107319418"/>
    <dbReference type="CTD" id="10143"/>
    <dbReference type="GeneTree" id="ENSGT00950000183186"/>
    <dbReference type="OrthoDB" id="10032136at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001503">
        <property type="term" value="P:ossification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03596">
        <property type="entry name" value="CLECT_tetranectin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.100.10:FF:000010">
        <property type="entry name" value="C-type lectin domain family 3 member A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051663">
        <property type="entry name" value="CLec_Tetranectin-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22799:SF2">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN FAMILY 3 MEMBER A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22799">
        <property type="entry name" value="TETRANECTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0430">Lectin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034989911" evidence="3">
        <location>
            <begin position="25"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="4">
        <location>
            <begin position="73"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005018058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="193" mass="22044" checksum="71DE10F43F37B585" modified="2022-01-19" version="1">MAQTGFMIFLLISILLLDQTISQASKFKARKHSKRRVKEKDDLKTQIDKLWREVNALKEMQALQSVCLRGTKAHKKCYLISEGTKHFHEANEDCIAKGGTLAIPRNSDETNALRDYGKNSMPGGSEFWLGVNDMVNEGKFVDVNGMALQYFNWDRAQPNGGKRENCVFFSTQGKWVDEVCRTAKRYICEFLIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YEC8</accession>
    <name>A0A8C2YEC8_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Notchless protein homolog 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">NLE1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015735862.1">
        <property type="nucleotide sequence ID" value="XM_015880376.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YEC8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005028105.1">
        <property type="protein sequence ID" value="ENSCJPP00005020375.1"/>
        <property type="gene ID" value="ENSCJPG00005016297.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107322395"/>
    <dbReference type="KEGG" id="cjo:107322395"/>
    <dbReference type="CTD" id="54475"/>
    <dbReference type="GeneTree" id="ENSGT00940000157881"/>
    <dbReference type="OrthoDB" id="10267436at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000129">
        <property type="entry name" value="Notchless homolog 1 (Drosophila)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057855">
        <property type="entry name" value="Beta-prop_WDR19_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012972">
        <property type="entry name" value="NLE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001632">
        <property type="entry name" value="WD40_G-protein_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF0">
        <property type="entry name" value="NOTCHLESS PROTEIN HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23389">
        <property type="entry name" value="Beta-prop_WDR19_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08154">
        <property type="entry name" value="NLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00319">
        <property type="entry name" value="GPROTEINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NLE" evidence="9">
        <location>
            <begin position="61"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="153"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="WDR19 first beta-propeller" evidence="10">
        <location>
            <begin position="167"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="195"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="238"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
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            <begin position="285"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="411"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="453"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="495"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF08154"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF23389"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005020375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="528" mass="58187" checksum="97304051A0E31A8A" modified="2022-01-19" version="1">MESPTGLLRPLGWVPAGARLPRSGLSPCLGPSAAELPLPRPGPERAVPQSMEPTEDAERLLIQFRDEAGEPLGSPFDVPVSITPDKLQLVCNALLQQDEPVPLAFFFHDAEIVVSLEKTLAGQAVETEKVLDIIYQPQAVFRVRAVTRCTSSLEGHTEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPQFTAKGHRHWVLSIAWSPDGKKLASGCKNSQIFLWDPATGNQIGRVLTGHSKWITCLCWEPLHINPECRYLASASKDGSIRIWDTLMGRCDKILTGHTQSVTCVKWGGDGLLYSSSQDRTIKVWRSQDGVLCRTLQGHAHWVNTMALSTDYVLRTGAFEPAEATINPQDMSGSLAELKDKAQQRYDKVRGQGPERLVSGSDDFTLFLWRPAEDKKPLERMTGHQALINQVLFSPDTRIIASASFDKSIKLWEGRTGKYLTSLRGHVSAVYQIAWSADSRLLVSGSSDSTLKVWNAETKKLAIDLPGHADEVFATDWSPDGQRVASGGKDKCLRIWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YFJ3</accession>
    <name>A0A8C2YFJ3_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MyoD family inhibitor domain containing 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">MDFIC2</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MDFI family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2YFJ3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005031313.1">
        <property type="protein sequence ID" value="ENSCJPP00005022848.1"/>
        <property type="gene ID" value="ENSCJPG00005018163.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00730000111641"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026134">
        <property type="entry name" value="MDFI/MDFIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15304">
        <property type="entry name" value="MYOD FAMILY INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15304:SF2">
        <property type="entry name" value="MYOD FAMILY INHIBITOR DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15316">
        <property type="entry name" value="MDFI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005022848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="212" mass="24132" checksum="82CB7905644B610B" modified="2022-01-19" version="1">MSEAKTDKAQIKPAESFENDKQNISWLKKDSCTSSLPLPVLHEVMLSSEDHPENQLTNEKHTDEKTVKGIVMSSVAEFSMADTSSKETKNEKKLSEASRSSIASLEKCREFTYIEDDASVHQRDSDDECATLILACLFCQFWDFLIMLPDTCEHWLIDTCCPSNRYYQTSDEDHSNNDCNCDCDIDCSLFESCHETGECLELAMEISEVCYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YFQ1</accession>
    <name>A0A8C2YFQ1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Sodium/hydrogen exchanger</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">SLC9A7</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Recycling endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2YFQ1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005031813.1">
        <property type="protein sequence ID" value="ENSCJPP00005023184.1"/>
        <property type="gene ID" value="ENSCJPG00005018302.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153460"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098719">
        <property type="term" value="P:sodium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004709">
        <property type="entry name" value="NaH_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002090">
        <property type="entry name" value="NHE-6/7/9"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00840">
        <property type="entry name" value="b_cpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="SODIUM/HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110:SF62">
        <property type="entry name" value="SODIUM_HYDROGEN EXCHANGER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01084">
        <property type="entry name" value="NAHEXCHNGR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01088">
        <property type="entry name" value="NAHEXCHNGR6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0050">Antiport</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0967">Endosome</keyword>
    <keyword evidence="10 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0915">Sodium</keyword>
    <keyword evidence="12 13" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="6 13 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 13" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034420026" description="Sodium/hydrogen exchanger" evidence="16">
        <location>
            <begin position="17"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="335"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="454"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="483"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="17">
        <location>
            <begin position="61"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="19"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="538"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="641"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="641"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005023184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="697" mass="77382" checksum="A730BC649D05C43F" modified="2022-01-19" version="1">MALPLLVLLGAGGLLAAERSGGGGGGSSSAMEELATEQEAEESHRQDSVSLLTFILLLTLTILTIWLFKHRRVRFLHETGLAMIYGLIVGVILRYGTPSSSGRDKPLSCSQEDRPFTTLLVNVSGKFFEYTLKGEISPGKIHNVEQNDMLRKVTFDPEVFFNILLPPIIFHAGYSLKKRHFFRNLGSILAYAFLGTAVSCFIIGNLMYGVVKLMKLVGQLSDKFYYTDCLLFGAIISATDPVTVLAIFNELHADVDLYALLFGESVLNDAVAIVLSSSIVAYQPTGENTHAFDAAAFFKSVGVFLGIFSGSFMMGAVTGVVTFTKLHCFPLLETALFFLMSWSTFLLAEACGFTGVVAVLFCGITQAHYTYNNLSVESRSRTKQLFEVLHFLAENFIFSYMGLALFTFQKHMFSPVFIIGAFIAIFLGRAAHIYPLSFLLNLGRRHKISWNFQHMMMFSGLRGAMAFALAIRDTATYAHQMMFSTTLLIVFFTVWIVGGGTTPMLSWLQIRVGDRVPSVEEMSESRWLYFRVGVDPDQDPPPTNDNFQVLQGDGPDSERRNRTKQESAWLFRLWYSFDHNYLKPILTHSGPPLTTTLPSWCGLIARCLTSPQVYDNQEQLREEDSDFILNDSDLTVTYGDTTITANGSSGPHTATTSLDGRRTKSSSEEALERDLGAAEHEVASRGTRLVFPLEDNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YGE4</accession>
    <name>A0A8C2YGE4_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Iodothyronine deiodinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">DIO2</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endomembrane system</location>
            <topology evidence="3">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the iodothyronine deiodinase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2YGE4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005033459.1">
        <property type="protein sequence ID" value="ENSCJPP00005024567.1"/>
        <property type="gene ID" value="ENSCJPG00005019350.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154482"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004800">
        <property type="term" value="F:thyroxine 5'-deiodinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033798">
        <property type="term" value="F:thyroxine 5-deiodinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042446">
        <property type="term" value="P:hormone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042404">
        <property type="term" value="P:thyroid hormone catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000643">
        <property type="entry name" value="Iodothyronine_deiodinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11781">
        <property type="entry name" value="IODOTHYRONINE DEIODINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11781:SF20">
        <property type="entry name" value="TYPE II IODOTHYRONINE DEIODINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00837">
        <property type="entry name" value="T4_deiodinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0712">Selenocysteine</keyword>
    <keyword evidence="4" id="KW-0893">Thyroid hormones biosynthesis</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005024567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="125" mass="14285" checksum="3873F015133B2AC2" modified="2022-01-19" version="1">IFKFLKIEEFSGVADFLLVYIDEAHPSDGWAAPGISPSSFEVKKHRNQEDRCAAAHQLLERFSLPPQCQVVADCMDNNANVAYGVSFERVCIVQRQKIAYLGGKGPFFYNLQEVRLWLEQNFSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YGM7</accession>
    <name>A0A8C2YGM7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Retinoblastoma-associated protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">pRb</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">RB1</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the retinoblastoma protein (RB) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015707281.1">
        <property type="nucleotide sequence ID" value="XM_015851795.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YGM7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005034264.1">
        <property type="protein sequence ID" value="ENSCJPP00005025166.1"/>
        <property type="gene ID" value="ENSCJPG00005019775.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107308151"/>
    <dbReference type="KEGG" id="cjo:107308151"/>
    <dbReference type="CTD" id="5925"/>
    <dbReference type="GeneTree" id="ENSGT00950000183202"/>
    <dbReference type="OrthoDB" id="844594at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061793">
        <property type="term" value="C:chromatin lock complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008024">
        <property type="term" value="C:cyclin/CDK positive transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016605">
        <property type="term" value="C:PML body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035189">
        <property type="term" value="C:Rb-E2F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097718">
        <property type="term" value="F:disordered domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061676">
        <property type="term" value="F:importin-alpha family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019900">
        <property type="term" value="F:kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051219">
        <property type="term" value="F:phosphoprotein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061629">
        <property type="term" value="F:RNA polymerase II-specific DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003180">
        <property type="term" value="P:aortic valve morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048667">
        <property type="term" value="P:cell morphogenesis involved in neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032869">
        <property type="term" value="P:cellular response to insulin stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002062">
        <property type="term" value="P:chondrocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048565">
        <property type="term" value="P:digestive tract development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043353">
        <property type="term" value="P:enucleate erythrocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050673">
        <property type="term" value="P:epithelial cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034349">
        <property type="term" value="P:glial cell apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014009">
        <property type="term" value="P:glial cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097284">
        <property type="term" value="P:hepatocyte apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034088">
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        <property type="term" value="P:negative regulation of cell growth"/>
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        <property type="term" value="P:negative regulation of glial cell proliferation"/>
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        <property type="term" value="P:negative regulation of inflammatory response"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:negative regulation of myofibroblast differentiation"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:negative regulation of smoothened signaling pathway"/>
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        <property type="term" value="P:neuron apoptotic process"/>
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        <property type="term" value="P:positive regulation of collagen fibril organization"/>
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        <property type="term" value="P:protein localization to chromosome, centromeric region"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="RETINOBLASTOMA-ASSOCIATED PROTEIN"/>
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    <keyword evidence="7" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="79"/>
            <end position="216"/>
        </location>
    </feature>
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            <begin position="650"/>
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    </feature>
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    <sequence length="919" mass="104326" checksum="A4A499B651F774FA" modified="2022-01-19" version="1">MPPKPLRRAGAARSQRTSPEGGGSASPPGGTRLEVGEAEFVALCDALKVPDSVREKAWRTYESLAAADGAPAYNKKKKETWGVCIFIVAIDLDEMTFTFTELLKSLSISVCTFFQFLKEVDVNMDTVSTKVDSTVSRLKKKYDVLLALYHKFERTCGLIYLDQPSSEISAELTSVLVLKNYWITFLLAKGKVLQMEDDLVISFQLLLCVLDYFIKLSPPAMLKEPYKSAVTALTANGSTRTPRRGQNRNARASKQIDTDTKVIEILCKEHDCNLDEVKNVYFTSFIPFLNSLGVASNGLPEVDVLSKQYDELYLKNKDIDARLFLDHDETLQPDVIACSQLERTPQKNIPDEEVNHVLPQTPVRAAMNTIQQLMMILNSATDKPSDTLIAYFNNCTVNPEDSILKRVESLGHIFKKKFAEAVGQGCAEIGSQRYQLGVRLYYRVMESMLKSEEERLSVHNFSKLLNDNIFHTSLLACALEIVMATYGRTASQSDGTSTETDLSFPWILNVFDLKAFDFYKVIESFIKVEPSLTRDMIKHLERCEHRIMESLAWQSDSPLFDLIKQSKEREGQTDQPEPTSTLNLPLQHNHTAADLYLSPVRSPKKKASGHPQSGTSNPDAQPSATSQTQKPQKSTSLSLFYKKVFRLAYLRLHTLFFRLLSEHPDLEPLIWTLFQHTLQNEYELMRDRHLDQIMMCSMYGICKVKNVDLRFKTIVSAYKELPNTNQETFKRVLIREEQYDSIIVFYNLVFMQKLKTNILQYASNRPPTLSPIPHIPRSPYQFSNSPRRVPAGNNIYISPLKSPYKFSDGFQSPTKMTPRSRILVSIGETFGTSEKFQKINQMVCNSESHVKRGAEPSDAPKPLKRLRFDIEGQDEADGGKHLPQESKFQQKLAEMTSTRTRMQKQKQNDGNDTSGNEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YGP3</accession>
    <name>A0A8C2YGP3_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Collagen alpha-1(XXVII) chain-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC107321846</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <dbReference type="Ensembl" id="ENSCJPT00005034388.1">
        <property type="protein sequence ID" value="ENSCJPP00005025262.1"/>
        <property type="gene ID" value="ENSCJPG00005019849.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162727"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030020">
        <property type="term" value="F:extracellular matrix structural constituent conferring tensile strength"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1000:FF:000003">
        <property type="entry name" value="Collagen alpha-1(XXVII) chain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1000:FF:000006">
        <property type="entry name" value="collagen alpha-1(XXVII) chain isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000085">
        <property type="entry name" value="collagen alpha-1(XXVII) chain isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1000">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050149">
        <property type="entry name" value="Collagen_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000885">
        <property type="entry name" value="Fib_collagen_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048287">
        <property type="entry name" value="TSPN-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023:SF844">
        <property type="entry name" value="COLLAGEN ALPHA-1(XXVII) CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01410">
        <property type="entry name" value="COLFI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00038">
        <property type="entry name" value="COLFI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00210">
        <property type="entry name" value="TSPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51461">
        <property type="entry name" value="NC1_FIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0176">Collagen</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Fibrillar collagen NC1" evidence="9">
        <location>
            <begin position="1544"/>
            <end position="1744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="306"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="507"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="728"/>
            <end position="1510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="306"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="384"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="398"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="429"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="520"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="540"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="795"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="816"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="916"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="933"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1014"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1086"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1125"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1140"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1200"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1210"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1234"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1289"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="1392"/>
            <end position="1401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1487"/>
            <end position="1504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005025262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1773" mass="180002" checksum="C18656D7B16CD99D" modified="2022-01-19" version="1">MEPESEPVSRLRATAAGRGGFCFVWTVLCFSWFLGFTQGNSEDVDVLQRLGLGGRRPSSGLSSSHAIPQGVIPLKSGVIFTQRARIEAPISTIFPAGSSTDLLLVLSLCSHRINNAFLFAVKSKKKRLQLGVQFVPGKIIVYVGHKRSVYFDYNVHDGQWHNMAINIRGQTVTLFTSCGKHRVHADLHFKKDEALDPHGSFLFGKMNHHSVQFEGAICQFDIYPSAKAAHHYCKYLKKQCRQADTYRPNLPPLIPILPRDPSASPSTPQHTEPLLQGLKNLTTATPSLAFGKVTAPLKTRGSGATTVALVSSQPPLPRQTTKATKVTVAPSSTGTQPPTRSLPRGTVTPLRVSRPTSSTHTGEKTPLSSAKKAQPTSPSPATASRKETKQETKKKINQKPTTKSSEAPSTVKPTRRRIDNTTSSIHFVTLKQTPQTPTTGPLPKKHVPAPSRKGDLGNVTLVYTKPPLGAAHPVSRAQAQAFNLTTPAATDGYQIFDPLGPTPFPFLLGYPGVKGDRGPQGPPGLPGLPGPPGKRGSRGPPGPHGNPGSPGPPGLKGQKGDPGLSPGKARRGPKGDVGLPGLTGFPGPPGRKGYKGYPGPPGHPGDQGERGPAGSPGAKGYPGRQGLPGPIGEAGPKGSRGYIGLPGLFGLPGADGERGIPGVPGKRGKMGRPGFPGDFGERGPPGIDGNPGELGAPGPPGVLGLIGDMGSVGPIGYPGPKGLKGLMGNPGEHGLKGDKGDQGGAGLPGDIGFQGDKGSHGLPGLPGARGKPGPVGKVGDMGPMGFPGPPGPEGFPGDIGPPGENGPEGPKGKPGARGLPGPRGLPGQEGDEGPIGPSGVPGSEGRPGRKGFPGRPGPDGPKGEPGNNGRPGKVGEQGLMGFIGPVGEPGIVGEKGDRGSVGPPGPPGDKGSMGHPGIPGAVGFPGIPGPAGPAGARGAPGIRGVKGRRGARGPDGPVGEPGSRGAKGRPGEPGKLGPDGLQGKMGETGETGSRGFPGIQGPSGPPGAKGAPGDPGPQGPRGPPGPLGEIGHKGPPGPMGPPGLAGEPGMKGDPGQLGVPGEQGLIGQRGEMGLEGDSGPPGPDGAKGDKGEQGLDGEKGEKGTEGLKGKEGPPGYPGITGVRGPEGKPGKQGEKGKPGQKGSKGYQGQLGETGPPGKEGPKGNQGPKGSRGTLGPMGAPGRMGAQGEPGLKGYQGHAGPPGPIGPPGPKGEKGEQGDDGKVEGPQGPPGDRGPFGDRGDRGEPGDPGYPGQEGLDGERGKPGQQGLPGDPGPPGQPGAKGSKGDVGQKGKQGARGSAGSRGSPGTLGLPGPRGVVGRQGQEGAPGVDGVPGKDGLPGVLGEQGDDGEEGITGMAGKRGNPGVPGLPGAQGPPGFKGERGLPGQNGQTGKRGSLGGMGLPGSPGDPGPKGQPGDFGETGFPGIAGIFGPKGPPGDPGFKGIQGPRGPPGLMGKEGIIGPHGIQGPTGNPGPKGDKGSRGDMGLQGPRGPPGPRGQPGPPGPPGIPASFQQDGFGAAFRTLVDSNTALKTEGYQHPDLLMLDHGGEIFKTLHYLSNLIQSIKRPLGTKENPARICRDLMNCEQKMKDGTYWIDPNLGCSSDTIQVICNFTNGGQTCLSPITVSKLDFDVGRVQMNFLRLLSSEVVQHITIHCLNTSVWREGSAEKPSQKAVRFKAWNGQMFEAEGQLKPEVAADDCKIKDGRWHRTLFSFRTQDTQQLPIVNIYNLPPSEPGKQYHLEGLCSKDSWAVSFGSTLALAFGSRSQRTRDLLNSAGC</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-02-11" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q9DET5</accession>
    <name>TB15A_COTJA</name>
    <protein>
        <recommendedName>
            <fullName>Thymosin beta-15A homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Thymosin beta</fullName>
        </alternativeName>
    </protein>
    <organism>
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2000-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Dathe V.E."/>
                <person name="Prols F."/>
                <person name="Brand-Saberi B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the thymosin beta family.</text>
    </comment>
    <dbReference type="EMBL" id="AJ301650">
        <property type="protein sequence ID" value="CAC17010.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015715596.1">
        <property type="nucleotide sequence ID" value="XM_015860110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9DET5"/>
    <dbReference type="SMR" id="Q9DET5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005017927.1">
        <property type="protein sequence ID" value="ENSCJPP00005012367.1"/>
        <property type="gene ID" value="ENSCJPG00005010515.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107312570"/>
    <dbReference type="KEGG" id="cjo:107312570"/>
    <dbReference type="CTD" id="286527"/>
    <dbReference type="GeneTree" id="ENSGT00940000161604"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003785">
        <property type="term" value="F:actin monomer binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030334">
        <property type="term" value="P:regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.520:FF:000001">
        <property type="entry name" value="Thymosin beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.520">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001152">
        <property type="entry name" value="Beta-thymosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038386">
        <property type="entry name" value="Beta-thymosin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12021">
        <property type="entry name" value="THYMOSIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12021:SF11">
        <property type="entry name" value="THYMOSIN BETA-15A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01290">
        <property type="entry name" value="Thymosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001828">
        <property type="entry name" value="Thymosin_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00152">
        <property type="entry name" value="THY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00500">
        <property type="entry name" value="THYMOSIN_B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0009">Actin-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0206">Cytoskeleton</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="initiator methionine" description="Removed" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000185160" description="Thymosin beta-15A homolog">
        <location>
            <begin position="2"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="19"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="45" mass="5245" checksum="653D699D474590CB" modified="2007-01-23" version="3">MCDKPDLSEVEKFDKKKLKKTNTEEKNTLPSKETIEQEKECVKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SMD1</accession>
    <name>A0A8C2SMD1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Triple QxxK/R motif-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">TRIQK</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRIQK family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SMD1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005000736.1">
        <property type="protein sequence ID" value="ENSCJPP00005000389.1"/>
        <property type="gene ID" value="ENSCJPG00005000478.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000017350"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024842">
        <property type="entry name" value="TRIQK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20583">
        <property type="entry name" value="TRIPLE QXXK/R MOTIF-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20583:SF1">
        <property type="entry name" value="TRIPLE QXXK_R MOTIF-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15168">
        <property type="entry name" value="TRIQK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005000389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="75" mass="8712" checksum="14A5C497C02E8363" modified="2022-01-19" version="1">MGRKDASTARTPVDQYRKQIGKQDYKKTRPMLRATRLKAEAKKTALGVKVQFSLIAYSTFVYLLFLFPIDVLHEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SMV4</accession>
    <name>A0A8C2SMV4_COTJA</name>
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        <submittedName>
            <fullName evidence="7">EF-hand domain family member D2</fullName>
        </submittedName>
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        <name evidence="7" type="primary">EFHD2</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    <dbReference type="Ensembl" id="ENSCJPT00005001944.1">
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        <property type="gene ID" value="ENSCJPG00005001196.1"/>
    </dbReference>
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        <property type="component" value="Chromosome 21"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="AIF-1_EF_pair"/>
    </dbReference>
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        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
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        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040365">
        <property type="entry name" value="EFHD1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13025">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13025:SF2">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21008">
        <property type="entry name" value="AIF-1"/>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="EF_HAND_2"/>
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    </dbReference>
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    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="73"/>
            <end position="108"/>
        </location>
    </feature>
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        <location>
            <begin position="109"/>
            <end position="144"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <location>
            <begin position="181"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005001132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="218" mass="24578" checksum="F5CFAADB00EE9AC6" modified="2022-01-19" version="1">MAEELAERLGRRLGMREGDAEQQQQQQQQQQDAEPTPVPPGSPAVRALGSEGSPGGGRRLFSPAAEFREFSRRQLRDMERLFRQYDAGKDGFIDLMELKLMMEKLGAPQTHLGLKNMIKEVDEDLDSKLSFREFLLIFRKAAAGELQEDSGLHALARLSEIDVSTEGVKGAKSFFEAKVSAGSFEEEIRAEQEEKRRQAEEMKQRKAAFKELQSAFAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SNB1</accession>
    <name>A0A8C2SNB1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Interleukin-6 receptor subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Interleukin-6 signal transducer</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Membrane glycoprotein 130</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Oncostatin-M receptor subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">IL6ST</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
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            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type I cytokine receptor family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015704207.1">
        <property type="nucleotide sequence ID" value="XM_015848721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SNB1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005002206.1">
        <property type="protein sequence ID" value="ENSCJPP00005001306.1"/>
        <property type="gene ID" value="ENSCJPG00005001351.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107305990"/>
    <dbReference type="KEGG" id="cjo:107305990"/>
    <dbReference type="CTD" id="3572"/>
    <dbReference type="GeneTree" id="ENSGT00940000159608"/>
    <dbReference type="OrthoDB" id="9934532at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome Z"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070110">
        <property type="term" value="C:ciliary neurotrophic factor receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="C:dendrite"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005896">
        <property type="term" value="C:interleukin-6 receptor complex"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005900">
        <property type="term" value="C:oncostatin-M receptor complex"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005127">
        <property type="term" value="F:ciliary neurotrophic factor receptor binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="F:coreceptor activity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="F:identical protein binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="F:interleukin-11 binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004915">
        <property type="term" value="F:interleukin-6 receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005138">
        <property type="term" value="F:interleukin-6 receptor binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004923">
        <property type="term" value="F:leukemia inhibitory factor receptor activity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="F:oncostatin-M receptor activity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="F:protein tyrosine kinase activator activity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:cell surface receptor signaling pathway via JAK-STAT"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005977">
        <property type="term" value="P:glycogen metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060576">
        <property type="term" value="P:intestinal epithelial cell development"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043524">
        <property type="term" value="P:negative regulation of neuron apoptotic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of adaptive immune response"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of astrocyte differentiation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of osteoblast differentiation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042102">
        <property type="term" value="P:positive regulation of T cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="Cytokine receptor like factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000414">
        <property type="entry name" value="Interleukin-6 receptor subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000524">
        <property type="entry name" value="Interleukin-6 receptor subunit beta"/>
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    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000542">
        <property type="entry name" value="Interleukin-6 receptor subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="interleukin-6 receptor subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000855">
        <property type="entry name" value="Interleukin-6 receptor subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003529">
        <property type="entry name" value="Hematopoietin_rcpt_Gp130_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010457">
        <property type="entry name" value="IgC2-like_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050379">
        <property type="entry name" value="Type-I_Cytokine_Rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23036">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23036:SF83">
        <property type="entry name" value="INTERLEUKIN-6 RECEPTOR SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06328">
        <property type="entry name" value="Lep_receptor_Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01353">
        <property type="entry name" value="HEMATOPO_REC_L_F2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="9 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 20" id="KW-0732">Signal</keyword>
    <keyword evidence="5 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034184031" description="Interleukin-6 receptor subunit beta" evidence="20">
        <location>
            <begin position="33"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="632"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="21">
        <location>
            <begin position="138"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="21">
        <location>
            <begin position="236"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="21">
        <location>
            <begin position="340"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="21">
        <location>
            <begin position="530"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="726"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="785"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="884"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="785"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="800"/>
            <end position="809"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00068277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00077050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00078919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00083382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005001306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="925" mass="103156" checksum="D9E1AC242F0A6F1D" modified="2022-01-19" version="1">MAGIPSSMFSGWNWAVYCLYLFLNICSFEVSGGLVQSCGHIIPESPVLALGSNFTALCILNESCLDFGNIYASQIIWKMKNKVVPKEQYREINRTVSSVTFNDTSSLASPLTCNVLADGQIEQNIYGISVTVGLPPEKPENLSCIVNQVSKLTYPMKCTWNPGRPTFLDTHFRLKYRWSRESFPDCIPRYLNNSCTISDVQFFVNLEVWVEAANALGKAESDRLVFDPIEIVKPLPPHNLSVNSGILPTVLKLSWENRISAAVMKLKFNIRYRISSDTNWMQVPPEDTASPRTSFSIQGLRPYTEYVFSIRCMKEDGVGFWSDWSEEKIGVTTEDKPSRGPAIWRTIDASPSPSFWTVRLMWKALEPYEANGVILLYEVTVRAKPPLSHPPWRYNVTTTSLTLKLPNGTYEVTLIAHNRVGASPPSVLLIPSSNSKAPVKNIRTLPKDGKLWVGWAAPNNVLKYVIEWCLMSNSSDCITEWQIEPGSIQGTYLKGDIKPFKCYLITVYPLYADGQGSGQSVKAYLQQDRPSKGPTVQTKKVGKAEAVLTWNHLTVDEQNGFIRSYTILYKTVDGNETAVSVDPSKTEYTLSSLASDTLYTVRMMAYTDEGGRSGPDFTFTTQKFGRGEIEAIVVPVCLAFLLIVLLGVLFCFNKRDLIKKHIWPNVPDPSKSNIAQWSPQVPAKHNFSSKDQMYPEGSFTDVSVVEIEADDKKSFSEQDLKPFDLLKKEKSTSEGHSSGIGGSSCMSSPRQSVSDSDEGETTQNTSSTVQYSTVVLNGYRDQTPVQVFSRSESTQPLLDSEERLEDHAGGSDSMTQRQHYFRQNCGQDETKTDRPFFERAKQIIAANEEDLAGFAQLQISGQSPQPLGFELEESTQEAALPDVLQTSTEGQTVRPETVEGNEPSVDEMPKSYLPQTVRQGGYVPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SNG0</accession>
    <name>A0A8C2SNG0_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SNG0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005000448.1">
        <property type="protein sequence ID" value="ENSCJPP00005000224.1"/>
        <property type="gene ID" value="ENSCJPG00005000305.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000287948"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005000224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="188" mass="19434" checksum="D20C8FB3D1D639DD" modified="2022-01-19" version="1">MAEETSSPCYRGQGCTVGHGNIVGQDHIVRQGRAAGQGHTVGQGHVIGQGHAVGQGHVVGQGHVIGQGHVIGQGHVIGQSHVIGQGHVIGQGHVIGQGHVIGQGHVIGQGHVEEQWFIGEQLLVPRESCNHVGWKRALGSPAHPTAHVPQCPIPVLTQHPQGWGLPPALGSCAVLTALWSTAWSPSPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SPI7</accession>
    <name>A0A8C2SPI7_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">X-ray repair cross complementing 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">XRCC2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SPI7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005002147.1">
        <property type="protein sequence ID" value="ENSCJPP00005001253.1"/>
        <property type="gene ID" value="ENSCJPG00005001304.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000020445"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033063">
        <property type="term" value="C:Rad51B-Rad51C-Rad51D-XRCC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007098">
        <property type="term" value="P:centrosome cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042148">
        <property type="term" value="P:DNA strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035264">
        <property type="term" value="P:multicellular organism growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043524">
        <property type="term" value="P:negative regulation of neuron apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022008">
        <property type="term" value="P:neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050769">
        <property type="term" value="P:positive regulation of neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000269">
        <property type="term" value="P:regulation of fibroblast apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010332">
        <property type="term" value="P:response to gamma radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010165">
        <property type="term" value="P:response to X-ray"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001756">
        <property type="term" value="P:somitogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd19490">
        <property type="entry name" value="XRCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030547">
        <property type="entry name" value="XRCC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46644">
        <property type="entry name" value="DNA REPAIR PROTEIN XRCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46644:SF2">
        <property type="entry name" value="DNA REPAIR PROTEIN XRCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="1">
        <location>
            <begin position="16"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005001253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="278" mass="31522" checksum="39E051659377944F" modified="2022-01-19" version="1">MGDALRRAESGTQLLARLEGRSSLKNLEPNLFAEEGSPGHGDVIEFHGPEGTGKTEMLYHLIARCIIPKSGGGLEVEVMFIDTDYHFDMLRLVTILEHRLEQSTEEMMKRCLGRLYLVNCNSSTQLLLTLHSLENMFCTHPSLCLLIVDSISAFYWIDRSNGGESLNSQEMNLKKCANFLEKLVSEHHLVLVATTQSIMQKSTNSAESFFPLKLQHEIDADYRPYLCKSWQQMVTHRIFFSKQFNSGNSKGFTLVSCHLKKNHVTKRPFSIAECGVQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SPK6</accession>
    <name>A0A8C2SPK6_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Junctophilin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">JPH2</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the junctophilin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015737094.1">
        <property type="nucleotide sequence ID" value="XM_015881608.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SPK6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005001680.1">
        <property type="protein sequence ID" value="ENSCJPP00005000954.1"/>
        <property type="gene ID" value="ENSCJPG00005001047.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107322974"/>
    <dbReference type="KEGG" id="cjo:107322974"/>
    <dbReference type="CTD" id="57158"/>
    <dbReference type="GeneTree" id="ENSGT00940000159411"/>
    <dbReference type="OrthoDB" id="284854at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030314">
        <property type="term" value="C:junctional membrane complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016529">
        <property type="term" value="C:sarcoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070300">
        <property type="term" value="F:phosphatidic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005547">
        <property type="term" value="F:phosphatidylinositol-3,4,5-trisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080025">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010314">
        <property type="term" value="F:phosphatidylinositol-5-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055074">
        <property type="term" value="P:calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007204">
        <property type="term" value="P:positive regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055024">
        <property type="term" value="P:regulation of cardiac muscle tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.110.10:FF:000001">
        <property type="entry name" value="Junctophilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.110.10:FF:000003">
        <property type="entry name" value="Junctophilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017191">
        <property type="entry name" value="Junctophilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23085">
        <property type="entry name" value="GH28348P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23085:SF26">
        <property type="entry name" value="JUNCTOPHILIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037387">
        <property type="entry name" value="Junctophilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="692"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="162"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="256"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="451"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="269"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="455"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="472"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="513"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="607"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR037387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005000954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="714" mass="76921" checksum="1AC9FFBFB99773C8" modified="2022-01-19" version="1">MSGGRFDFDDGGAYCGGWEGGKAHGHGICTGPKGQGEYSGSWNHGFEVVGVYTWPSGNTYQGTWAQGKRHGIGMESKGKWVYKGEWTHGFKGRYGARQSMNSGAKYEGTWNNGLQDGYGTETYADGGTYQGQFTNGMRHGYGVRQSVPYGMASVVRSPLRTSLSSLRSEHSNGTLPQQDSPAAHPESLPASPTITRGGFALSLYADAEAGKVKKGGLFRRGSLLGKLKKSESKSSLASQKSRVSFLKSESGISSAASDATSTASLGEGAEGEEYPPFESDIDATTTETYMGEWKNDKRSGYGVSERSSGLKYEGEWLDNLRHGYGCTTLPDGKKEEGKYRHNVLVKGMKKRVIPLKSAKIRQKVDRSVEGAQRAAAIARQKSEIAASRTTHAKAKAESSEQAAQAANNESGIARMMARELSPDFYQPGPEYQKRRLLQEIMENAEHAVNMEEATPPQPKGAPPPPTPPESPQLHEQDEAPRRRSPAPSPASTPPEAKRAKAQQDGALRPGSWAGAGGGGASDGEGRPASRGSARPAEQMEIGPLQRMARGSDAEHYKGYHSYAVRTSPVSPAADYEEEPLSERGPPSPEPQIEPQRHGGTPVPIQEPMERHTPQVEANVEQHPHPKEHKQPRQRLSPEHKAVSRSEPAADRKTEGRAPGRTEHKAGAKRSPAPVMAVAAAQDAEEGDEGPNTIVICMVILLNIGLAILFVHFLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SQF6</accession>
    <name>A0A8C2SQF6_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">protein-glutamine gamma-glutamyltransferase</fullName>
            <ecNumber evidence="6">2.3.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">TGM3</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-glutaminyl-[protein] + L-lysyl-[protein] = [protein]-L-lysyl-N(6)-5-L-glutamyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:54816"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10207"/>
            <dbReference type="Rhea" id="RHEA-COMP:14005"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:138370"/>
            <dbReference type="EC" id="2.3.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="9">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the transglutaminase superfamily. Transglutaminase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.13" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2SQF6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005004101.1">
        <property type="protein sequence ID" value="ENSCJPP00005002266.1"/>
        <property type="gene ID" value="ENSCJPG00005002469.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01050000244866"/>
    <dbReference type="OrthoDB" id="437511at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031234">
        <property type="term" value="C:extrinsic component of cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003810">
        <property type="term" value="F:protein-glutamine gamma-glutamyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030216">
        <property type="term" value="P:keratinocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000090">
        <property type="entry name" value="Protein-glutamine gamma-glutamyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000278">
        <property type="entry name" value="Protein-glutamine gamma-glutamyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.260.10:FF:000001">
        <property type="entry name" value="Protein-glutamine gamma-glutamyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000171">
        <property type="entry name" value="protein-glutamine gamma-glutamyltransferase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.260.10">
        <property type="entry name" value="Transglutaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050779">
        <property type="entry name" value="Transglutaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036985">
        <property type="entry name" value="Transglutaminase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023608">
        <property type="entry name" value="Transglutaminase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013808">
        <property type="entry name" value="Transglutaminase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008958">
        <property type="entry name" value="Transglutaminase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036238">
        <property type="entry name" value="Transglutaminase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001102">
        <property type="entry name" value="Transglutaminase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11590">
        <property type="entry name" value="PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11590:SF36">
        <property type="entry name" value="PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00927">
        <property type="entry name" value="Transglut_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00868">
        <property type="entry name" value="Transglut_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000459">
        <property type="entry name" value="TGM_EBP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49309">
        <property type="entry name" value="Transglutaminase, two C-terminal domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00547">
        <property type="entry name" value="TRANSGLUTAMINASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4 9" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transglutaminase-like" evidence="11">
        <location>
            <begin position="265"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="354"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="394"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="396"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000459-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000459-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005002266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="692" mass="76922" checksum="E7394EA653853118" modified="2022-01-19" version="1">MGQAATQPSTDWHVKENGREHHTSKFSSKELVVRRGQAFVITFNGIEQPEQTLTFIAETGPKPSKQAKTLATFGISSTASKESWSAVLQSTSSNSVSVSISSPPNAVIGRYKLSVQSTSTGSSSPEALGTFVLLFNPWSSGDDVFMPNKAECEEYVLEEFGIIFAGNSYHINSFGWNYGQFQADILNICLAMLDRSLNYRQDPATDVSHRHDPKYLGRVLSAMVNANDDQGVVRGNWSGNYEGGKSPSSWTGSGEILQNWKQSGFKPVRYGQCWVFAAVLTTVLRCLGIPTRTVTNFSSAHDADGNLRVDEFYDASGNHLNEGADSVWNFHVWNESWFSRSDLGPSYSGWQILDATPQEESGGIYQCGPASRNAVKEGDVDLDYDCPFVFAEVNADCMYWNYDPATRKKTLLFNKSTVIGQLISTKAVGRDDRIDITSDYKYEEGSKKERDTFKKARKKLGLEDKFDPTAPTPKEIEQKPDISGRFKMAGPLEVGKDLDLILVLTNLQSEVKSVNVNMTAWSTMYTRKPVREIWKDSLSVSLSPEEEKHFPIKISYAEYQQQLTTDNAIEVTALCNVEGGIQVLVQRHIALDNPAIEIQVLGEAKVNKEVDVEVVFTNPIDIEVKDCVLQVEGSDLLRGILKIEVPPLKAREISSMKFKLTPFETGSKHLLVNFSCDKFADIKAFKTVKVID</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SSR1</accession>
    <name>A0A8C2SSR1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcriptional enhancer factor TEF-5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">TEAD3</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SSR1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005003766.1">
        <property type="protein sequence ID" value="ENSCJPP00005002100.1"/>
        <property type="gene ID" value="ENSCJPG00005002268.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182956"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061629">
        <property type="term" value="F:RNA polymerase II-specific DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055059">
        <property type="term" value="P:asymmetric neuroblast division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048568">
        <property type="term" value="P:embryonic organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035329">
        <property type="term" value="P:hippo signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.50.80:FF:000001">
        <property type="entry name" value="Transcriptional enhancer factor TEF-1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.40">
        <property type="entry name" value="TEA/ATTS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000818">
        <property type="entry name" value="TEA/ATTS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038096">
        <property type="entry name" value="TEA/ATTS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050937">
        <property type="entry name" value="TEC1_TEAD_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027253">
        <property type="entry name" value="TEF-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016361">
        <property type="entry name" value="TEF_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041086">
        <property type="entry name" value="YBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11834">
        <property type="entry name" value="TRANSCRIPTIONAL ENHANCER FACTOR TEF RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11834:SF7">
        <property type="entry name" value="TRANSCRIPTIONAL ENHANCER FACTOR TEF-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01285">
        <property type="entry name" value="TEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17725">
        <property type="entry name" value="YBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002603">
        <property type="entry name" value="TEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500720">
        <property type="entry name" value="TEF-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00065">
        <property type="entry name" value="TEADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00426">
        <property type="entry name" value="TEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51088">
        <property type="entry name" value="TEA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TEA" evidence="10">
        <location>
            <begin position="99"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="TEA" evidence="8">
        <location>
            <begin position="99"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="58"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="85"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR002603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005002100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="484" mass="53704" checksum="CE5EE80146730F2A" modified="2022-01-19" version="1">MSQDRAACITSGTRVLSSCRASIGDVLGLCCHLQLQHGHDSCGQVSGFSLCSHRLPRVRGGSGSEPRAASTIASNSWNASSSPGEGREDGQDGMDKSLDNDAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVRLDQVSKDKALQSMASMSSAQIVSASVLQNKLSPPPPLPQAVFSAAPRFWSGPIPGQPGPSQDIKPFAQPAYPIQPPMPPSLASKCYEPLAPLPPAASAVPVWQDRTIASAKLRLLEYSAFMEVPRDTETYSKHLFVHIGQTNPSYSDPLLEAVDIRQIYDKFPEKKGGLKELYERGPQNSFFLVKFWADLNSTIQDGPGTFYGVSSQYSSAENMTITVSTKVCSFGKQVVEKVETEYARLENSRFVYRIHRSPMCEYMINFIHKLKHLPEKYMMNSVLENFTILQVVTNRDTQETLLCIAFVFEVSTSEHGAQHHVYKLVKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SSV1</accession>
    <name>A0A8C2SSV1_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Telomerase RNA component interacting RNase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">TRIR</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SSV1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005005796.1">
        <property type="protein sequence ID" value="ENSCJPP00005003227.1"/>
        <property type="gene ID" value="ENSCJPG00005003454.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000012267"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038838">
        <property type="entry name" value="TRIR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34753">
        <property type="entry name" value="TELOMERASE RNA COMPONENT INTERACTING RNASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34753:SF1">
        <property type="entry name" value="TELOMERASE RNA COMPONENT INTERACTING RNASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005003227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="161" mass="16842" checksum="88EEBDE1F354A491" modified="2022-01-19" version="1">MSPCLHIPLVPHAAPCPTGRPCSAPGRPPGRAALPGTAHGDEGEAPSPPPGPGGGVNVFANDGSFLELFKRKMEAEQQREREAAAAAEATGGAGPGPQRSVGRRRGGNKLALKTGVVAKKQKTDEEVLTSKGDAWAKYMAEVKKYKAHQCSDDDKTRPLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SSX8</accession>
    <name>A0A8C2SSX8_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SSX8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005005850.1">
        <property type="protein sequence ID" value="ENSCJPP00005003263.1"/>
        <property type="gene ID" value="ENSCJPG00005003490.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005003263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="74" mass="7969" checksum="0D12E16B8357ED68" modified="2022-01-19" version="1">MGLVLIQNGAGSGFDLKWEMERTGLWGRLRVRGGVNVGTDMGSIEPRHPGARQRSVRGNEGIKPWVQGLQGAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2STE3</accession>
    <name>A0A8C2STE3_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aprataxin</fullName>
            <ecNumber evidence="4">3.6.1.71</ecNumber>
            <ecNumber evidence="3">3.6.1.72</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Forkhead-associated domain histidine triad-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">APTX</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP-NH(2)) and diadenosine tetraphosphate (AppppA), but with lower catalytic activity. Likewise, catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA, but has higher specific activity with 5'-linked adenosine (AppDNA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 3'-end 2'-deoxyribonucleotide-3'-diphospho-5'-guanosine-DNA + H2O = a 3'-end 2'-deoxyribonucleotide 3'-phosphate-DNA + GMP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:52140"/>
            <dbReference type="Rhea" id="RHEA-COMP:13186"/>
            <dbReference type="Rhea" id="RHEA-COMP:13187"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:136419"/>
            <dbReference type="ChEBI" id="CHEBI:136420"/>
            <dbReference type="EC" id="3.6.1.72"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 5'-end adenosine-5'-diphospho-5'-2'-deoxyribonucleoside-DNA + H2O = a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + AMP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:52128"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:13181"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:136413"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.6.1.71"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 5'-end adenosine-5'-diphospho-5'-ribonucleoside-2'-deoxyribonucleotide-DNA + H2O = a 5'-end 5'-phospho-ribonucleoside-2'-deoxyribonucleotide-DNA + AMP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:52132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13182"/>
            <dbReference type="Rhea" id="RHEA-COMP:13183"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136414"/>
            <dbReference type="ChEBI" id="CHEBI:136415"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.6.1.71"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.71" evidence="4"/>
    <dbReference type="EC" id="3.6.1.72" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2STE3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005006235.1">
        <property type="protein sequence ID" value="ENSCJPP00005003533.1"/>
        <property type="gene ID" value="ENSCJPG00005003689.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156806"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome Z"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033699">
        <property type="term" value="F:DNA 5'-adenosine monophosphate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120108">
        <property type="term" value="F:DNA-3'-diphospho-5'-guanosine diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008967">
        <property type="term" value="F:phosphoglycolate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051219">
        <property type="term" value="F:phosphoprotein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990165">
        <property type="term" value="F:single-strand break-containing DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031647">
        <property type="term" value="P:regulation of protein stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000012">
        <property type="term" value="P:single strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01278">
        <property type="entry name" value="aprataxin_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000004">
        <property type="entry name" value="aprataxin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041388">
        <property type="entry name" value="FHA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12486:SF4">
        <property type="entry name" value="APRATAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12486">
        <property type="entry name" value="APRATAXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11969">
        <property type="entry name" value="DcpS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17913">
        <property type="entry name" value="FHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="17">
        <location>
            <begin position="211"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="112"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="112"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005003533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="464" mass="52752" checksum="46A284A526702BEE" modified="2022-01-19" version="1">MRPWRSAAMRDCWLLAMEERGLRVLLPHMADVVLGRGPLTGITDRRCSRRQVVLKADCNEGYVTVKQIGVNTTSVDLVDVGKGEEVKMRPGQVLHMVNRRYPFVVEFSEFSEESEETVTEEEEKTQTEKRPFEESCVDDTENVPRKAKKMMVMDTLSSFSDFRPSKSSTPLFEESTSGKVLSVGNFSGEPVSQECSEHELSHTKEHLGHWSQGLKSAMQDPKEQVYKDEKTVVIKDKYPKARYHWLILPWDSISSLKSVTREHLELLEHMHSVGQKMIEQCPAKGSLEFRLGYHAIPSMSQLHLHVISQDFDSPALKTKKHWNSFTTEYFLNSKVMKIQPEDCAVLRSVPSLCPSADKKKYTVVLEAFYMPAIHLAYHNHTSLNTIEKPQLLQLAAAVVLCVWFPSTKQHWESRRCCLGHHTLSQLLCESGNTFTEYHLTVVLGSVHTLCCKISGSYEGVTFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SV42</accession>
    <name>A0A8C2SV42_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tectonin beta-propeller repeat containing 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">TECPR2</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="Ensembl" id="ENSCJPT00005004603.1">
        <property type="protein sequence ID" value="ENSCJPP00005002512.1"/>
        <property type="gene ID" value="ENSCJPG00005002769.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157283"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032527">
        <property type="term" value="P:protein exit from endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056499">
        <property type="entry name" value="Beta-prop_HPS5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006624">
        <property type="entry name" value="Beta-propeller_rpt_TECPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23287">
        <property type="entry name" value="RUBY-EYE2-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23287:SF16">
        <property type="entry name" value="TECTONIN BETA-PROPELLER REPEAT-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23756">
        <property type="entry name" value="Beta-prop_HPS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06462">
        <property type="entry name" value="Hyd_WA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19193">
        <property type="entry name" value="Tectonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00706">
        <property type="entry name" value="TECPR"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HPS5-like beta-propeller" evidence="2">
        <location>
            <begin position="41"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="511"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="725"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="788"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="450"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="536"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="751"/>
            <end position="763"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005002512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1461" mass="160782" checksum="E6F0312C0225927A" modified="2022-01-19" version="1">MPVLAMASVASPVLFKEFCPLYYLLNAIPTKIQKGFRSIVVYLTALDTNGDYIAVGSSIGMLYLYCRHLNQMKKYNFEGKCESITSVKLLSCFDDLVAVGTASGRVAVFQLVSSLPGRNKQLRRFDVAGIHKSSITALAWSPNGMKLFSGDDRGKIVYSALDLDHGVCNSSLVLEEPSSIVQLDYNQKVLLVSTLQRTILFYTEEKSVKQVGTQPRKNSGKFGACFIPGLCKQTDLTLFAARPGLRLWKSDVHGTVQATFILKDLFARGIQTFELYPRLEPPDRGSYGSPEKHLGLVSCFFREGWVLTWNEYSIYLLDTVNQALIGGLEGYGDIVSVSCTSNEIFLLKGDRDIIRISSRPEGLSSLDGNSKLLNPSTDTSPHLLTPISVAASTSSSLSVETDKKIVTSPSVVGEKGDSLVKDDLETPILLEKSFDRVGDLSNETRKRGCSVASESRSRSSSVNSVDSGSSFMIYADQFSEAQRECQLSSQRFSTISSEDFDQELIVKPIKVKKKKKKKQESGTKRNHISLEGTPNYERQLSGDSPHSMNADSFSMTSSLMSGSIDHLSTGSPDQESMFSVESNTVLQEDNGSETFSILQSPESATVLINEENGNTVDLQKLPNSDSGMGTSTITDALTSVSPPILTEDLTSTVVTENNHCVFSASNECCPGKLGQEEQDFSTLCKINENLDKMKLQDGEKCFEELDQTLLERSSILGVQASLTLNESDETSREDQQQHSLTVSAPSVPSVHHSDISKGVDSEHSSISGWNFESVIKGKSTTSTAEWVTNTHESKAEEESASSDEEDIYGHGLPYSSSETSVPEVGAEPGSQDLARISLDEMVLLKSDQFAESWMGYSGPGYGILSLAVSEKYIWCLDYRGSLYCSALPSAGLRWQKFEDGVQQVAVSPSGALLWKIEQKTNKAFACGKVTIKGKRHWYEALPQAVFVALSDDTAWIIRTNGDLYLQTGLSVDRPCARAVKVDCPYPLSQVTSRNNVVWALSEQRALLYREGVRSFCPEGEQWKSDIVSEIQALEPVCITLGDQQTLWALDIHGNLWFRTGVVSKKPQGDDNHWWQVSITDYVVFDQCSLFQTIIQATHSVATAAQAPVEKVADKLRMAFWSQQLQCQPSLLGVNGSGVWISSGKNEFHVAKGNLIGTYWNIIVPRGTASATKWVFVLASPASSKEGSFLWLCQSNKDLFCVSDQSPQFRPSTVQLPPETEMVHYSACQDAIWGLDSLGQIFIRTLSSSCPTGMHWTKLDLSQLGAVKLVSLACGNQHVWACDTSGGVYFRVGTQPLNPSLMLPAWIMIEPPIQPVGINLVSIHSSPNDQMLWAIDSKWNVHVRVGITEEMPVGTDWEHVPGLQACELAISTRTVWARCPNGDVARRYGITDKNPAGDYWKKIPGNVTRLTVTPLDELWAISTSGSLLQRLTKTLSHSHNQQKNDTSVLLHPDDFEDEWEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SVS9</accession>
    <name>A0A8C2SVS9_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Charged multivesicular body protein 2B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">CHMP2B</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF7 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015735449.1">
        <property type="nucleotide sequence ID" value="XM_015879963.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SVS9"/>
    <dbReference type="SMR" id="A0A8C2SVS9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005005698.1">
        <property type="protein sequence ID" value="ENSCJPP00005003165.1"/>
        <property type="gene ID" value="ENSCJPG00005003401.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107322199"/>
    <dbReference type="KEGG" id="cjo:107322199"/>
    <dbReference type="CTD" id="25978"/>
    <dbReference type="GeneTree" id="ENSGT00950000182832"/>
    <dbReference type="OrthoDB" id="5594417at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904930">
        <property type="term" value="C:amphisome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005828">
        <property type="term" value="C:kinetochore microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032585">
        <property type="term" value="C:multivesicular body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050890">
        <property type="term" value="P:cognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902774">
        <property type="term" value="P:late endosome to lysosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061952">
        <property type="term" value="P:midbody abscission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007080">
        <property type="term" value="P:mitotic metaphase chromosome alignment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071985">
        <property type="term" value="P:multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070050">
        <property type="term" value="P:neuron cellular homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031468">
        <property type="term" value="P:nuclear membrane reassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001778">
        <property type="term" value="P:plasma membrane repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010824">
        <property type="term" value="P:regulation of centrosome duplication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901673">
        <property type="term" value="P:regulation of mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043162">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046761">
        <property type="term" value="P:viral budding from plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0039702">
        <property type="term" value="P:viral budding via host ESCRT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="25"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005003165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="214" mass="24016" checksum="7E3BE92B7743E626" modified="2022-01-19" version="1">MASLFKKKTVDDIIKEQNRELRGTQRTITRDRAALEKQEKQLELEIKKMAKTGNKEACKVLAKQLVQLRKQKNRTYAVSSKVTSMSTQTKVMNSQMKMAGAMSTTAKTMQAVNKKMDPQKTLQTMQNFQKENMKMEMTEEMINDTLDDIFDASDEEEESQDIVNQVLDEIGIEISGKMAKAPSAARGLPSASTSKAATISDEEIERQLKALGVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SW28</accession>
    <name>A0A8C2SW28_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VWFD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SW28"/>
    <dbReference type="Ensembl" id="ENSCJPT00005005278.1">
        <property type="protein sequence ID" value="ENSCJPP00005002884.1"/>
        <property type="gene ID" value="ENSCJPG00005003162.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFD" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005002884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="83" mass="8977" checksum="E903F41D8B0E4233" modified="2022-01-19" version="1">MLSVTVPSSYHNSTCGLCGNFDGRHHNDHLHRNDVATYFHRCEKAMAAKGLMPPPCQWLLQAVTSPSAPCGVPMTPPYPSGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SX01</accession>
    <name>A0A8C2SX01_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DnaJ homolog subfamily C member 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Cysteine string protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">DNAJC5</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Cytoplasmic vesicle</location>
            <location evidence="12">Secretory vesicle</location>
            <location evidence="12">Chromaffin granule membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Melanosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015737293.1">
        <property type="nucleotide sequence ID" value="XM_015881807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SX01"/>
    <dbReference type="SMR" id="A0A8C2SX01"/>
    <dbReference type="Ensembl" id="ENSCJPT00005007216.1">
        <property type="protein sequence ID" value="ENSCJPP00005004281.1"/>
        <property type="gene ID" value="ENSCJPG00005004272.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107323083"/>
    <dbReference type="KEGG" id="cjo:107323083"/>
    <dbReference type="CTD" id="80331"/>
    <dbReference type="GeneTree" id="ENSGT00940000155597"/>
    <dbReference type="OrthoDB" id="445556at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042584">
        <property type="term" value="C:chromaffin granule membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042470">
        <property type="term" value="C:melanosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031594">
        <property type="term" value="C:neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008021">
        <property type="term" value="C:synaptic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043524">
        <property type="term" value="P:negative regulation of neuron apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051402">
        <property type="term" value="P:neuron apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098693">
        <property type="term" value="P:regulation of synaptic vesicle cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000017">
        <property type="entry name" value="dnaJ homolog subfamily C member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051434">
        <property type="entry name" value="DnaJ_C_subfamily_member5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44027:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44027">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0564">Palmitate</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="16">
        <location>
            <begin position="15"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="159"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="176"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00042238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005004281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="198" mass="22098" checksum="2AE2A56DECC970BC" modified="2022-01-19" version="1">MADQRQRSLSTSGESLYHVLGLDKNATSDDIKKSYRKLALKYHPDKNPDNPEAAEKFKEINNAHAILTDATKRNIYDKYGSLGLYVAEQFGEENVNTYFVLSSWWAKALFVFCGLITGCYCCCCLCCCCNCCCGKCKPKPPEGEEQEYYVSPEDLEAQLQSDEREASDAPIVIQPASATETTQLTADSHPSYHTDGFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SXA8</accession>
    <name>A0A8C2SXA8_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Rho GTPase activating protein 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ARHGAP12</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SXA8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005006040.1">
        <property type="protein sequence ID" value="ENSCJPP00005003412.1"/>
        <property type="gene ID" value="ENSCJPG00005003588.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182860"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001891">
        <property type="term" value="C:phagocytic cup"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002011">
        <property type="term" value="P:morphogenesis of an epithelial sheet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051058">
        <property type="term" value="P:negative regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006911">
        <property type="term" value="P:phagocytosis, engulfment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13233">
        <property type="entry name" value="PH_ARHGAP9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04403">
        <property type="entry name" value="RhoGAP_ARHGAP27_15_12_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12070">
        <property type="entry name" value="SH3_ARHGAP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000003">
        <property type="entry name" value="Putative rho GTPase-activating protein 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000024">
        <property type="entry name" value="Rho GTPase activating protein 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000056">
        <property type="entry name" value="rho GTPase-activating protein 12 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035491">
        <property type="entry name" value="ARHGAP12_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF107">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16618">
        <property type="entry name" value="SH3-WW_linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="79"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="7">
        <location>
            <begin position="329"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="7">
        <location>
            <begin position="428"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="6">
        <location>
            <begin position="491"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="8">
        <location>
            <begin position="718"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="262"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="356"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="450"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="643"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="373"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="390"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="455"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="653"/>
            <end position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005003412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="908" mass="102662" checksum="481A8B67473D9796" modified="2022-01-19" version="1">MYLTEVDIGELTALFVKLFSSQVHSDTYFIVSTSFSFFLTALIVNRKPTLLKQNVAKCLLEKVKFLLVVMADRSAKILPGQLYIEVEYDYEYEAKDKKIVIKQGEKYILVKKTNDDWWQVKRDENSKPFYVPAQYVKEIPRKALMPPVKQAGVLPNNALKLTHGLQRSTENVNKSPELSSFGKSSPVQVSCLVRDANQNLGPNNSPGQTLGLSLDLTQNNGKLNNELQSPKVSNQFRTISMGHFPCPEFLEIEKTSFLHEQSCDSAGEGSEKIHQDSESGDELSSSSTEQAQPTTPPSQGRPDSPVYANLQELKISQSALPPLPTSAPVQINGEWETHKDTTGRCYYYNRGSQERTWKPPRWARDASINKGDSQSHADHEHLSSEENDHSSCYSQSDSQYGSPPKGWSEELDEHGQTLYTNDYTNEKWLKHADEQGRPYYYSADGSRSEWELPKESSSSSKASFPENESSPSSPKHQATGQEKYGLLNVTKITENGKKVRKNWMSSWAVLQGSSLLFTKTQGSGTGWSFCLGGSIPELLLSLLSSWKNALSRRPAVTYVNSTQVSAISKFGVNQSKPEFTVDLKGALIDWASKDKSSKKNVIELKTRQGTELLIQSDNDSFINEWYKVLNYTINNQVVESDEALEDEVPDSPGLEKQDKEKEKENKDSKKLRSVKVPSNIDATDQKKTKTKLKKFLTRRPTLQAVREKGYIKDQVFGSNLTSLCQRENSTVPKFVKLCIEHVEEHGLDVDGLYRVSGNLAVIQKLRFAVNHDEKLDLNDSKWEDIHVITGALKMFFRELPEPLFTYNHFNDFVNAIKQEPRQRVHAVKDLIKQLPKPNQDTMQVLFRHLKRVVENGEKNRMTYQSIAIVFGPTLLKPEKETGNIAVHTVYQNQIVELILLELNAVFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SXL8</accession>
    <name>A0A8C2SXL8_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Solute carrier family 11 member 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">SLC11A2</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lysosome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NRAMP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015742463.1">
        <property type="nucleotide sequence ID" value="XM_015886977.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SXL8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005007570.1">
        <property type="protein sequence ID" value="ENSCJPP00005004533.1"/>
        <property type="gene ID" value="ENSCJPG00005004470.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107325802"/>
    <dbReference type="CTD" id="4891"/>
    <dbReference type="GeneTree" id="ENSGT00940000155330"/>
    <dbReference type="OrthoDB" id="409173at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome LGE22C19W28_E50C23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045178">
        <property type="term" value="C:basal part of cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031526">
        <property type="term" value="C:brush border membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903561">
        <property type="term" value="C:extracellular vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070826">
        <property type="term" value="C:paraferritin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046870">
        <property type="term" value="F:cadmium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015086">
        <property type="term" value="F:cadmium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015087">
        <property type="term" value="F:cobalt ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015094">
        <property type="term" value="F:lead ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015099">
        <property type="term" value="F:nickel cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015295">
        <property type="term" value="F:solute:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048813">
        <property type="term" value="P:dendrite morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048821">
        <property type="term" value="P:erythrocyte development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033212">
        <property type="term" value="P:iron import into cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007611">
        <property type="term" value="P:learning or memory"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060586">
        <property type="term" value="P:multicellular organismal-level iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010039">
        <property type="term" value="P:response to iron ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00221">
        <property type="entry name" value="NRAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001046">
        <property type="entry name" value="NRAMP_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01197">
        <property type="entry name" value="nramp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037982">
        <property type="entry name" value="Nramp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706:SF40">
        <property type="entry name" value="NATURAL RESISTANCE-ASSOCIATED MACROPHAGE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706">
        <property type="entry name" value="SOLUTE CARRIER PROTEIN FAMILY 11 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01566">
        <property type="entry name" value="Nramp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00447">
        <property type="entry name" value="NATRESASSCMP"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0410">Iron transport</keyword>
    <keyword evidence="8" id="KW-0458">Lysosome</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="208"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="294"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="439"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="473"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="505"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005004533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="566" mass="61915" checksum="DA9DFEA81469E24C" modified="2022-01-19" version="1">MVTSRSGRSAMGESKDGPAESVGSVSGSRNTLQPLQGEEDEEPFSTYFDSKIPIPEDDTHSCFSFRKLWAFTGPGFLMSIAYLDPGNIESDLQSGAVAGFKLLWVLLLATVIGLLLQRLAARLGVVTGLHLAEVCNRQYHKVPRIMLWLMMEIAIIGSDMQEVIGTAIAFSLLSMGKIPLWGGVLITIADTLFFLFLDKYGLRKLEAFFGFLITIMALTFGYEYVTVKPDQKQLLRGLFVPECPGCGTPQLEQAVGIVGAVIMPHNMYLHSALVKSRQVNRANPREVREANKYFFAESCIALFVSFIINVFVVSVFAEAFYNKTNMDVHEVCANASSVHAGLFPNNNNTLEVDIYKGGAVLGCYFGPAALYIWAIGILAAGQSSTMTGTYSGQFVMEGFLNLRWSRFARVLLTRSIAITPTLFVAIFQDVEHLTGMNDFLNVLMSLQLPFALIPVLTFTSLPSVMNDFANGLFWKVGGGLVILLVCSINMYFVVAYVMALNHVGLYVGAAILSIAYLGFVTYLTWLCLIALGASALSCGSTRCWAFTARPELVLLSNVGGDTEVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SYF2</accession>
    <name>A0A8C2SYF2_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">5-phosphohydroxy-L-lysine phospho-lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">PHYKPL</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015731109.1">
        <property type="nucleotide sequence ID" value="XM_015875623.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SYF2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005008844.1">
        <property type="protein sequence ID" value="ENSCJPP00005005452.1"/>
        <property type="gene ID" value="ENSCJPG00005005220.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005008846.1">
        <property type="protein sequence ID" value="ENSCJPP00005005454.1"/>
        <property type="gene ID" value="ENSCJPG00005005220.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107320110"/>
    <dbReference type="KEGG" id="cjo:107320110"/>
    <dbReference type="CTD" id="85007"/>
    <dbReference type="GeneTree" id="ENSGT00940000159222"/>
    <dbReference type="OrthoDB" id="10261433at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000058">
        <property type="entry name" value="ethanolamine-phosphate phospho-lyase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45688">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45688:SF6">
        <property type="entry name" value="5-PHOSPHOHYDROXY-L-LYSINE PHOSPHO-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005005454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="451" mass="50729" checksum="5CE10DF54C2744C4" modified="2022-01-19" version="1">MRRAQRSRQETLSLRRQLIGSSCKLFYPNDPLKIVKARGQYMYDENGRQYLDCINNVAHVGHCHPDVVKAAHEQNQLLNTNSRYLHDNLTDYAERLSEKLPDKLCTFYFLNSGSEANDLALRMARQFTKHEDVIVLDHAYHGHLTSLIDISPYKFRNLGGQKEWVHVAPVPDTYRGLYREDHEDPVTAYANEVKNIIKQAHKKGRKIAAFFAESLPSVGGQILPPEGYFQKVAEHVHKAGGVFVADEIQVGFGRVGKHFWAFQLQGEDFIPDIVTMGKPIGNGHPIACVATTKEIAEAFAATGVEYFNTFGGNPVSCAIGLAVLDVIEKEQLQVHATEVGNFFMKLLMEQKIKHPLIGDVRGSGLFIGVDLIKDQAKRTPATEEAEYLIIRLKEEYILLSTDGPGRNVLKFKPPMCFTMEDAKFVVDTIDKLLTDMEKEHLNQEKTSTGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SZV2</accession>
    <name>A0A8C2SZV2_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fibronectin type III domain containing 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FNDC11</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SZV2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005009923.1">
        <property type="protein sequence ID" value="ENSCJPP00005006283.1"/>
        <property type="gene ID" value="ENSCJPG00005005901.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000006008"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048317">
        <property type="entry name" value="DUF5581_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049231">
        <property type="entry name" value="DUF5581_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039581">
        <property type="entry name" value="FNDC11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14537">
        <property type="entry name" value="FIBRONECTIN TYPE III DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17744">
        <property type="entry name" value="DUF5581"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20996">
        <property type="entry name" value="DUF5581_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5581" evidence="2">
        <location>
            <begin position="24"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5581" evidence="1">
        <location>
            <begin position="198"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="303" mass="36032" checksum="65B96C4451E3572F" modified="2022-01-19" version="1">MNVNLDEFETNLENTVHSTEEQDNEIWRTYTERSNLVRQYLQSNLSLHVLEMHEKKVELLKKCCYYLEVLPTFLILRDQNLLALPTSIFQVIDPWKFQRVKKMAKSQTEVHLQLLTHLLEELQQGREELVCYVETCDMVTFLSKWDLIKQRMSDLSNIMNKFISIQVSRRLYTKHRLVSCADIRGNKIPDIRLFLCAKMPVMFDRKESFAHRNWAHLKWSTENQETPHEQYELHFKLLKCGTQAEFGHCGLMTRTTNNCVVQGLLPDRSYEFMIRRAETYTLVYELWHDTITLTTKDTSFSHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T013</accession>
    <name>A0A8C2T013_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RWD domain containing 2B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">RWDD2B</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015736455.1">
        <property type="nucleotide sequence ID" value="XM_015880969.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T013"/>
    <dbReference type="Ensembl" id="ENSCJPT00005008042.1">
        <property type="protein sequence ID" value="ENSCJPP00005004896.1"/>
        <property type="gene ID" value="ENSCJPG00005004743.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107322676"/>
    <dbReference type="KEGG" id="cjo:107322676"/>
    <dbReference type="CTD" id="10069"/>
    <dbReference type="GeneTree" id="ENSGT00390000007224"/>
    <dbReference type="OrthoDB" id="432412at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23829">
        <property type="entry name" value="RWD_RWDD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd24163">
        <property type="entry name" value="RWDD2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017359">
        <property type="entry name" value="Phi-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010541">
        <property type="entry name" value="Prp3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059181">
        <property type="entry name" value="RWDD2A-B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15955">
        <property type="entry name" value="RWD DOMAIN CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15955:SF8">
        <property type="entry name" value="RWD DOMAIN-CONTAINING PROTEIN 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06544">
        <property type="entry name" value="Prp3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038021">
        <property type="entry name" value="UCP038021_RWDD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RWD" evidence="1">
        <location>
            <begin position="66"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005004896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="346" mass="39393" checksum="2634A06BDD11CD4C" modified="2022-01-19" version="1">MARYGAAGSFTSSRGNGLTLPGVLPARCIVGREGIGWAVHARRWRRDEWEEAGEMSSREEAEMQISELDLLSSMFPYEEEFAVTDQLAVAELKHFVENESAEMPSSKIQFILNVKPEDSHASMVKFTMVCALPFKYPSVLPEITVRSPLLSRSQQVQLNSDLKAYLMQNCSGEPCVLSAREWVKEQAATYIDRELSPSSVTTPNAVRSEDMVFTRLWIYSHHIYNKQKRKNIIEWSKELSLSGFCMPGKPGVVCVEGLQGSCEEFWSRIRRLTWKRILIRHREDISLEGGGLAEIQKQRKFSTLEEKCFDAHGARGNHMDLGQLYQFLEEKGCADIFQMYFGVEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T076</accession>
    <name>A0A8C2T076_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gamma-secretase activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">GSAP</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T076"/>
    <dbReference type="Ensembl" id="ENSCJPT00005008980.1">
        <property type="protein sequence ID" value="ENSCJPP00005005545.1"/>
        <property type="gene ID" value="ENSCJPG00005005285.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000012875"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001540">
        <property type="term" value="F:amyloid-beta binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902004">
        <property type="term" value="P:positive regulation of amyloid-beta formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030162">
        <property type="term" value="P:regulation of proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028010">
        <property type="entry name" value="GSAP_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026172">
        <property type="entry name" value="GSAP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13630">
        <property type="entry name" value="GAMMA-SECRETASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13630:SF1">
        <property type="entry name" value="GAMMA-SECRETASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14959">
        <property type="entry name" value="GSAP-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma-secretase-activating protein C-terminal" evidence="1">
        <location>
            <begin position="541"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005005545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="755" mass="87293" checksum="6FA226D72685F89D" modified="2022-01-19" version="1">MTLLAVSFRQYTEEERVTQLLQSVSKYLTLLIEIHPINNVRVLKAVDSCVRVQFLYPVECRNTSPESHLLLVSEDKYIEQFDIHVVAEEEHRVVIQNLGQLPRVRVADDLIWAQWDMTEQRLFYIVPKESRSTLKCIQFYPDENFNSTLESQLDISVSDKQIRFVNFGYNDCKDQDVASKSLNLQVFTSKAGGLCVCCSLASDIRGEITYSIYFLHKGFSKTFTVSLERPETPQLKEVAFLNLDYYVAAYLPGQFLHLLNIQHPDLLCYSLFLTGEDARIDMLPSCSIQSPLVSTVLDCCMGRMYAVSISDSALLKFLQSSERDSERLAALHCALLCVRSTTDLETKIIWWISENLSTCHSFDPIQEFIIASLYCKMCPETNNLDKLLPYTSLLDWTGVIPGVACATDIISLPVLEIQNSKGFWEKLDSNLESVKYAEPQLHYHNNVLRREWRILSEETEERRATAYLRNIFENAKKVLSHLDAWDSEERLVPLFQEEDYQQQLLMGLMVAQLKDHLMRHLQYVGKKKIDQIVLDYVANLLNLVHRIMKEVWKMYQLHSCIFCFDERGSEAEFRVFHIMSRILEAANGMCMPLPPGFHTLHLGLGVRCLPLHTLLHYIDNGVLHLTETCVRKLLKDLDDNEKNEKLKFSIVTRLPEALGLKARQFWDHPVNANFLARKYVKLLFEKLGNRQCSRPVPERHPVPVEFLPLNYLTNVLAEIENQGVHPYEKQDHINVRFVEEAALKHTMMLLGLRYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T0D9</accession>
    <name>A0A8C2T0D9_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chemokine interleukin-8-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T0D9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005009910.1">
        <property type="protein sequence ID" value="ENSCJPP00005006272.1"/>
        <property type="gene ID" value="ENSCJPG00005005890.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000287065"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome Z"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048020">
        <property type="term" value="F:CCR chemokine receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008009">
        <property type="term" value="F:chemokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061844">
        <property type="term" value="P:antimicrobial humoral immune response mediated by antimicrobial peptide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070098">
        <property type="term" value="P:chemokine-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048245">
        <property type="term" value="P:eosinophil chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.40:FF:000012">
        <property type="entry name" value="C-C motif chemokine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039809">
        <property type="entry name" value="Chemokine_b/g/d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001811">
        <property type="entry name" value="Chemokine_IL8-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036048">
        <property type="entry name" value="Interleukin_8-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12015:SF80">
        <property type="entry name" value="C-C MOTIF CHEMOKINE 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12015">
        <property type="entry name" value="SMALL INDUCIBLE CYTOKINE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00048">
        <property type="entry name" value="IL8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00199">
        <property type="entry name" value="SCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54117">
        <property type="entry name" value="Interleukin 8-like chemokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="3" id="KW-0202">Cytokine</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0395">Inflammatory response</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034281898" description="Chemokine interleukin-8-like domain-containing protein" evidence="8">
        <location>
            <begin position="23"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Chemokine interleukin-8-like" evidence="9">
        <location>
            <begin position="87"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="218" mass="23366" checksum="B0AB55B1260E757E" modified="2022-01-19" version="1">MHNGSACFLLPMCFLFPLSKKSLPLQGASLALGVPPWGHGRAPGMRGCPHQVVIIQPHFMAPVSMEPRSDLKNSRVVPPPVDAGNNVLDCCLRTREKPIPWRIVQDYRMQLVQDGCDIPATVFITAKGKQLCAPPQAPWVLRLREKLDASSARKVGAGPCSVHALGNGNSVGWVGSAPRQVVPVLLELQMALGTKQRSLLLPCCLGAGNVHLHGEGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T0T3</accession>
    <name>A0A8C2T0T3_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA replication fork stabilization factor DONSON</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">DONSON</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DONSON family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T0T3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005010490.1">
        <property type="protein sequence ID" value="ENSCJPP00005006698.1"/>
        <property type="gene ID" value="ENSCJPG00005006211.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000000447"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030894">
        <property type="term" value="C:replisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033260">
        <property type="term" value="P:nuclear DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024861">
        <property type="entry name" value="Donson"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12972">
        <property type="entry name" value="DOWNSTREAM NEIGHBOR OF SON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12972:SF0">
        <property type="entry name" value="PROTEIN DOWNSTREAM NEIGHBOR OF SON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02064">
        <property type="entry name" value="DONSON"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="513" mass="56562" checksum="EB3EF1E0A1A43872" modified="2022-01-19" version="1">MAATVPGYSPGFKKPPATLRLKRKRPRRSEPAAPQPCGAAPRATSAPVRRNPFSSLDNAPRQPGRRQQGEPAPPGGGPASAAPFWQVEPGERAREIPLQKAFVTLSASCFLPSVFRDLHLAVPTPNVPTSPSCEFPADWSIKTRLLFMSSQPFTWAEHLKAQEEAQGFAQHCRAAEINLPQTVQSLVYWLHPSLPWLQLFPRIGADRKIAGKACPWAQDEALQQALMSDWSVSFTSLYNLLKAKLCPYFYVCTYQFTVLFRAAGLAGSDVITAVISPTTRGLREAMRNEGIEFSLPLVEESRMILFLREAAPSDDDDDDGFSWLEEMGVQDKVKKPDAISIKLRKEKHEVQVDHRPESLAVVKGTNTFTLLNFLINCKSLVAVAGPQAGLPPTLLSPVAFRGGTMQTLKARSMNAKARVRLAYEDIYSLEIVGPVLPHSLHMLTMLLQSAQQGAFSAALYTHEPTAVFNTNLHNESTCGLHSKTLHQLSQVPTLGKSSLRFLEMKDSVCAWRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T117</accession>
    <name>A0A8C2T117_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">B-cell differentiation antigen CD72-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC107305760</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015703773.1">
        <property type="nucleotide sequence ID" value="XM_015848287.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T117"/>
    <dbReference type="Ensembl" id="ENSCJPT00005010614.1">
        <property type="protein sequence ID" value="ENSCJPP00005006806.1"/>
        <property type="gene ID" value="ENSCJPG00005006291.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107305760"/>
    <dbReference type="KEGG" id="cjo:107305760"/>
    <dbReference type="GeneTree" id="ENSGT00390000003668"/>
    <dbReference type="OrthoDB" id="8950604at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome Z"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039689">
        <property type="entry name" value="CD72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15028:SF6">
        <property type="entry name" value="B-CELL DIFFERENTIATION ANTIGEN CD72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15028">
        <property type="entry name" value="CD72-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="4">
        <location>
            <begin position="204"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="115"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="340" mass="38008" checksum="E63BF5958F00C21D" modified="2022-01-19" version="1">MAQGLLYADLRFAKGPGGRGMASQALEAALGMDEAESPHENTTPELPVGTAGEGAWRSPGCWSCWRCVPAGLLAVSLLLLVASLVLGACYWQVTRQLQDTSLEQAAERGRFSQEVQVRDQSLEKMRQELARVREELQQAWQEGNNSRRELGRWEAELEYVSGTLAATQKELNSVQGRLNASESTVTLLRSCTAIDCCPSGWLLYRGKCLFISTEKKTWDDSRAECEEKYSQLLITKSWSRWTVPSFLKNADVAYWIGLQKSKYPWYEYDWLEEGDADDEGLADAWIWVDGSLYERPWQPKSNGSCAVISRGNIKAAPCEGPEDLQLWICEKAAGPSSPFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T1S0</accession>
    <name>A0A8C2T1S0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ubiquitin-conjugating enzyme E2 G2</fullName>
            <ecNumber evidence="2">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">E2 ubiquitin-conjugating enzyme G2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Ubiquitin carrier protein G2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Ubiquitin-protein ligase G2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">UBE2G2</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Involved in endoplasmic reticulum-associated degradation (ERAD). Required for sterol-induced ubiquitination of 3-hydroxy-3-methylglutaryl coenzyme A reductase and its subsequent proteasomal degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.23"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Interacts with AUP1 (via C-terminus); the interaction recruits UBE2G2 to lipid droplets. Interacts with ubiquitin ligases AMFR/gp78 and RNF139/TRC8; recruitment to lipid droplets by AUP1 facilitates interaction of UBE2G2 with AMFR and RNF139, leading to sterol-induced ubiquitination of 3-hydroxy-3-methylglutaryl coenzyme A reductase and its subsequent proteasomal degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="2"/>
    <dbReference type="RefSeq" id="XP_015726715.1">
        <property type="nucleotide sequence ID" value="XM_015871229.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T1S0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005009292.1">
        <property type="protein sequence ID" value="ENSCJPP00005005793.1"/>
        <property type="gene ID" value="ENSCJPG00005005480.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107317968"/>
    <dbReference type="KEGG" id="cjo:107317968"/>
    <dbReference type="CTD" id="7327"/>
    <dbReference type="GeneTree" id="ENSGT00940000158193"/>
    <dbReference type="OrthoDB" id="19692at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035458">
        <property type="term" value="P:cellular response to interferon-beta"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904153">
        <property type="term" value="P:negative regulation of retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070936">
        <property type="term" value="P:protein K48-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd23796">
        <property type="entry name" value="UBCc_UBE2G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000008">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 14" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="15">
        <location>
            <begin position="4"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="13">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00055690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00063420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00073285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00076340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00079258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00079959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005005793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="165" mass="18575" checksum="CBDECF2F05119355" modified="2022-01-19" version="1">MAGTALKRLMAEYKQLTLNPPEGIVAGPMNEENFFEWEALIMGPEDTCFEYGVFPAILSFPLDYPLSPPKMRFTCEMFHPNIYPDGRVCISILHAPGDDPMGYESSAERWSPVQSVEKILLSVVSMLAEPNDESGANVDASKMWREDREQFNRIAKQIVQKSLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T2K0</accession>
    <name>A0A8C2T2K0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Syndecan/Neurexin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T2K0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005010709.1">
        <property type="protein sequence ID" value="ENSCJPP00005006876.1"/>
        <property type="gene ID" value="ENSCJPG00005006355.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155978"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027789">
        <property type="entry name" value="Syndecan/Neurexin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01034">
        <property type="entry name" value="Syndecan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Syndecan/Neurexin" evidence="7">
        <location>
            <begin position="302"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="160"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="346"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="160"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="348"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="396" mass="42628" checksum="8425A3BC1355A568" modified="2022-01-19" version="1">MGGWIDRCIYGWMDGQMDGWMDGWMDGWMDGWTDGWIDTWMDRQMDGWTDVYMGGWMDGWMDGRMDGRTDRRMYGCMSGRPGAVRASELGRARHLLTEVSLLFFLLFCFFFVNFLLIFSLFSSFFFVLFLPSCNFFFSTLKSPGPIPRCGELVLAAAPLSPSPSPSPRSVPPGCGPDCEEPSGFASGEAADSNVPPTDDEDFVSNPRGSPGTTGDIDTDTGNHRVVNRHRDVITPPGVTAVAITVSGPLPGLVPAGERHPREGGLGRGRVTVVPVTPRPVVPTAAAAPGAVEVVREAGGTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQVDQNRHYIGTTGPTAAMNDGNAGNAATTGSVSAVGNPKEKTTGNTPKAAGKARRNKDKEYYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T2P6</accession>
    <name>A0A8C2T2P6_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TRAF interacting protein with forkhead associated domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">TIFA</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T2P6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005011421.1">
        <property type="protein sequence ID" value="ENSCJPP00005007364.1"/>
        <property type="gene ID" value="ENSCJPG00005006794.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154589"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002753">
        <property type="term" value="P:cytoplasmic pattern recognition receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043123">
        <property type="term" value="P:positive regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033209">
        <property type="term" value="P:tumor necrosis factor-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033621">
        <property type="entry name" value="TIFA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31266:SF2">
        <property type="entry name" value="TRAF-INTERACTING PROTEIN WITH FHA DOMAIN-CONTAINING PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31266">
        <property type="entry name" value="TRAF-INTERACTING PROTEIN WITH FHA DOMAIN-CONTAINING PROTEIN A FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="86"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005007364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="119" mass="14035" checksum="4BFA67F43BF085C0" modified="2022-01-19" version="1">MTSFEEDETEETATCLHMTFYHPCQQDKMMFRCLNFCKREQVRADETAKFGRDSNVCHYNLVDTRVSRIQFSLQFYRKLNKLTKMLSASFLPILSLPAAHLLYSLTILLSVEFFSYCYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T4L3</accession>
    <name>A0A8C2T4L3_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 (FORS blood group)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">GBGT1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="11">Binds 1 Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 6 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T4L3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005011537.1">
        <property type="protein sequence ID" value="ENSCJPP00005007443.1"/>
        <property type="gene ID" value="ENSCJPG00005006862.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182858"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031982">
        <property type="term" value="C:vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047277">
        <property type="term" value="F:globoside alpha-N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02515">
        <property type="entry name" value="Glyco_transf_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000022">
        <property type="entry name" value="Histo-blood group ABO system transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005076">
        <property type="entry name" value="Glyco_trans_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10462:SF49">
        <property type="entry name" value="GLOBOSIDE ALPHA-1,3-N-ACETYLGALACTOSAMINYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10462">
        <property type="entry name" value="GLYCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03414">
        <property type="entry name" value="Glyco_transf_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="294"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="112"/>
            <end position="114"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-galactosamine</name>
            <dbReference type="ChEBI" id="CHEBI:67138"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-galactosamine</name>
            <dbReference type="ChEBI" id="CHEBI:67138"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="202"/>
            <end position="204"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-galactosamine</name>
            <dbReference type="ChEBI" id="CHEBI:67138"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>an alpha-L-fucosyl-(1-&gt;2)-beta-D-galactosyl derivative</name>
            <dbReference type="ChEBI" id="CHEBI:140327"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>an alpha-L-fucosyl-(1-&gt;2)-beta-D-galactosyl derivative</name>
            <dbReference type="ChEBI" id="CHEBI:140327"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>an alpha-L-fucosyl-(1-&gt;2)-beta-D-galactosyl derivative</name>
            <dbReference type="ChEBI" id="CHEBI:140327"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR605076-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605076-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605076-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005007443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="343" mass="39789" checksum="E4D71371103BDD65" modified="2022-01-19" version="1">MISKKALGSFVCLSAVATLIWLAVGNWKVHYIPYYLPCPGIFSKKLLYLEEKPPQLFPELFYQQPRVLAPKRQDVLTVTPWLAPIVWEGTFSPEILDSAYKPLNLTIGVTAFAIGKYTRFVRRFLESAEMHFMKGYRVNYYIFTDNPEVIPNVHLQPGRRFDVVHIKKYSSWQEISMRRMEAINLHIAEKSHQEVDYLFCLDIDMVFHNAWGAETLGDIVAAMHPGYFNVPRSKFPYERRSFSAAYIPDGEGDFYYGGAVFGGLVKKVYEFTKNCHMTILADKANGIVAAWQEESHLNRHFLSHKPSKVLSPEYIWDDRKPKPPEIFLIRFSTVDKNYQEIRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T549</accession>
    <name>A0A8C2T549_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Guanylate cyclase activator 2B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC107323563</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the guanylin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T549"/>
    <dbReference type="Ensembl" id="ENSCJPT00005011472.1">
        <property type="protein sequence ID" value="ENSCJPP00005007389.1"/>
        <property type="gene ID" value="ENSCJPG00005006820.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154436"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030250">
        <property type="term" value="F:guanylate cyclase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1450.10">
        <property type="entry name" value="Guanylin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000879">
        <property type="entry name" value="Guanylin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036382">
        <property type="entry name" value="Guanylin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11318:SF4">
        <property type="entry name" value="GUANYLATE CYCLASE ACTIVATOR 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11318">
        <property type="entry name" value="GUANYLIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02058">
        <property type="entry name" value="Guanylin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001849">
        <property type="entry name" value="Guanylin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00774">
        <property type="entry name" value="GUANYLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89890">
        <property type="entry name" value="Proguanylin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034647780" description="Guanylate cyclase activator 2B" evidence="9">
        <location>
            <begin position="27"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="71"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="103"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="106"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001849-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005007389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="115" mass="12892" checksum="3560D27C736D7DDB" modified="2022-01-19" version="1">FFAGAMRGFLSFTVLALLLLVHNSQEVYVQDGNFRFSLESVKKLKELMDESRVINPRMVVSKASKAGYSPCQDKDLPEEFQPVCKREDAPMIFKRLCIDADLCEICANAACSGCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T5S0</accession>
    <name>A0A8C2T5S0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Succinyl-CoA:glutarate CoA-transferase</fullName>
            <ecNumber evidence="14">2.8.3.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Dicarboxyl-CoA:dicarboxylic acid coenzyme A transferase SUGCT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Succinate--hydroxymethylglutarate CoA-transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">SUGCT</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Coenzyme A (CoA) transferase that reversibly catalyzes the transfer of a CoA moiety from a dicarboxyl-CoA to a dicarboxylate in a metabolite recycling process. Displays preference for succinyl-CoA and glutarate-CoA as dicarboxyl-CoA donors and glutarate, succinate, adipate/hexanedioate, itaconate and 3-hydroxy-3-methylglutarate as dicarboxylate acceptors. Acts on intermediates or end products of lysine and tryptophan degradation pathway, in particular catalyzes succinyl-CoA-dependent reesterification of free glutarate into glutaryl-CoA to prevent renal excretion of glutarate. Upon inflammation, may convert macrophage-derived itaconate to itaconyl-CoA in erythroid precursors where it negatively regulates the TCA cycle and heme synthesis to limit erythroid differentiation in the context of stress erythropoiesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>3-hydroxy-3-methylglutarate + glutaryl-CoA = (3S)-3-hydroxy-3-methylglutaryl-CoA + glutarate</text>
            <dbReference type="Rhea" id="RHEA:81723"/>
            <dbReference type="ChEBI" id="CHEBI:17325"/>
            <dbReference type="ChEBI" id="CHEBI:30921"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57378"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:81724"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:81725"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>3-hydroxy-3-methylglutarate + succinyl-CoA = (3S)-3-hydroxy-3-methylglutaryl-CoA + succinate</text>
            <dbReference type="Rhea" id="RHEA:12284"/>
            <dbReference type="ChEBI" id="CHEBI:17325"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="EC" id="2.8.3.13"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:12285"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="8">
            <dbReference type="Rhea" id="RHEA:12286"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>glutarate + succinyl-CoA = glutaryl-CoA + succinate</text>
            <dbReference type="Rhea" id="RHEA:67900"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30921"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:57378"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:67901"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="7">
            <dbReference type="Rhea" id="RHEA:67902"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>hexanedioate + glutaryl-CoA = hexanedioyl-CoA + glutarate</text>
            <dbReference type="Rhea" id="RHEA:81711"/>
            <dbReference type="ChEBI" id="CHEBI:17128"/>
            <dbReference type="ChEBI" id="CHEBI:30921"/>
            <dbReference type="ChEBI" id="CHEBI:57378"/>
            <dbReference type="ChEBI" id="CHEBI:76327"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:81712"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:81713"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>itaconate + glutaryl-CoA = itaconyl-CoA + glutarate</text>
            <dbReference type="Rhea" id="RHEA:81715"/>
            <dbReference type="ChEBI" id="CHEBI:17240"/>
            <dbReference type="ChEBI" id="CHEBI:30921"/>
            <dbReference type="ChEBI" id="CHEBI:57378"/>
            <dbReference type="ChEBI" id="CHEBI:57381"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:81716"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="9">
            <dbReference type="Rhea" id="RHEA:81717"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>itaconate + succinyl-CoA = itaconyl-CoA + succinate</text>
            <dbReference type="Rhea" id="RHEA:38283"/>
            <dbReference type="ChEBI" id="CHEBI:17240"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:57381"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:38284"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:38285"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CoA-transferase III family.</text>
    </comment>
    <dbReference type="EC" id="2.8.3.13" evidence="14"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2T5S0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005010489.1">
        <property type="protein sequence ID" value="ENSCJPP00005006697.1"/>
        <property type="gene ID" value="ENSCJPG00005006209.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157866"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047369">
        <property type="term" value="F:succinate-hydroxymethylglutarate CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10540:FF:000005">
        <property type="entry name" value="succinate--hydroxymethylglutarate CoA-transferase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1540.10:FF:000005">
        <property type="entry name" value="succinate--hydroxymethylglutarate CoA-transferase isoform X4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="entry name" value="formyl-coa transferase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050483">
        <property type="entry name" value="CoA-transferase_III_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48207">
        <property type="entry name" value="SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48207:SF3">
        <property type="entry name" value="SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00050578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00052509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00066474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00072178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00075311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00080717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="461" mass="49608" checksum="18F8ED26704AD4D8" modified="2022-01-19" version="1">MLGSELVRRCCGRGLWRSLCRTALSAASSSTCGGARGGGAPPAGASNVKPLDGVKILDLTRVLAGPFATMNLGDLGAEVIKVERPGTGDDTRAWGPPFVGTESVYFLSVNRNKKSIAINMKSSRGAKLIRELAAVSDVFVENYIPGKLAEIGLGYEDIKKIAPHIVYCSITGYGQTGPMAHRGGYDSIAAAISGLTHITGHEGGEPVRVGVAMTDLATGLYTCGAIMAGLLQKYKTGKGMHIDCNLLSSQVACLTHVAANYLNCKIEAKHWGTAHGSIVPYQAFKTKDGYIVVGAGNDQQFVTVCQILNLPEVIKDSRYKTNKLRVQNRKELIDILSTRFSEKTTVEWLQLFEGSGVPYGPINNMQQVFSEPQVLHNGLVMEMDHPIAGRIAVPVSGGIRIMCCLLWETSEVTNEVNFGRIILRIPTPSSLPFSHYVSKQKPAVSRSVNTAPFTSLEINLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T5S5</accession>
    <name>A0A8C2T5S5_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cytochrome P450 26B1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">CYP26B1</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>all-trans-retinoate + reduced [NADPH--hemoprotein reductase] + O2 = all-trans-18-hydroxyretinoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:55856"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:35291"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:139258"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:55857"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>all-trans-retinoate + reduced [NADPH--hemoprotein reductase] + O2 = all-trans-4-hydroxyretinoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51984"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:35291"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:134178"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:51985"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T5S5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005013436.1">
        <property type="protein sequence ID" value="ENSCJPP00005008935.1"/>
        <property type="gene ID" value="ENSCJPG00005007916.1"/>
    </dbReference>
    <dbReference type="KEGG" id="cjo:107314121"/>
    <dbReference type="GeneTree" id="ENSGT00800000124060"/>
    <dbReference type="OrthoDB" id="1372046at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008401">
        <property type="term" value="F:retinoic acid 4-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001972">
        <property type="term" value="F:retinoic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060349">
        <property type="term" value="P:bone morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034653">
        <property type="term" value="P:retinoic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd20637">
        <property type="entry name" value="CYP26B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000009">
        <property type="entry name" value="Cytochrome P450 26B1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286">
        <property type="entry name" value="CYTOCHROME P450 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286:SF177">
        <property type="entry name" value="CYTOCHROME P450 26B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 17 18" id="KW-0349">Heme</keyword>
    <keyword evidence="10 17 18" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 17 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 18" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="17">
        <location>
            <position position="440"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005008935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="511" mass="57679" checksum="80156F1DC825B207" modified="2022-01-19" version="1">MLFESFDLVSALATLAACLVSLTLLLAVSQQLWQLRWAATRDKTCKLPIPKGSMGFPLIGETFHWLLQGSCFQSSRREKYGNVFKTHLLGRPLVRVTGAENVRKILMGEHHLVSTEWPRSTRMLLGPNTVANSIGDIHRHKRKVFSKIFSHEALESYLPKIQLVIKDTLRAWSSNPDPINVYHEAQKLTFRMAIRVLLGFRIPDEELNRLFEVYQQFVENVFSLPVDLPFSGYRRGIRARETLQKGLEKAIQEKLQNTQGKDYADALDILIESGKEHGKELTMQELKDGTLELIFAAYATTASASTSLIMQLLKHPRVLEKLREELRSKGILHNGCICEGSLRLDNISGLHYLDCVIKEVLRLFTPISGGYRTVLQTFELDGFQIPKGWSVMYSIRDTHDTAPVFKDVDVFDPDRFGQGRSEDKEGRFHYLPFGGGVRTCLGKHLAKLFLKALAIELASTSRFELATRTFPKITLVPVVHPVDGLKVKFFGLDSNQNEILTGTDVILGATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T6B4</accession>
    <name>A0A8C2T6B4_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Splicing regulatory glutamic acid and lysine rich protein 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T6B4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005013703.1">
        <property type="protein sequence ID" value="ENSCJPP00005009148.1"/>
        <property type="gene ID" value="ENSCJPG00005008085.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00730000110872"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome Z"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12519">
        <property type="entry name" value="RRM1_SREK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000084">
        <property type="entry name" value="Serine/arginine-rich splicing factor 11 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32343">
        <property type="entry name" value="SERINE/ARGININE-RICH SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32343:SF71">
        <property type="entry name" value="SPLICING REGULATORY GLUTAMIC ACID AND LYSINE RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRM" evidence="1">
        <location>
            <begin position="22"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005009148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="98" mass="10429" checksum="A513F58BFEDCAD50" modified="2022-01-19" version="1">MNSGGIGVPLGFPLGPTSVIQVTNLSSAVTSEQMRTLFGFLGDIEELRLYPPDNAPLAFSSKVCYIKFREASSVGVAQHLTNTVFIDRALIVVPCAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T797</accession>
    <name>A0A8C2T797_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Olfactomedin 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">OLFM1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Synapse</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015734842.1">
        <property type="nucleotide sequence ID" value="XM_015879356.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T797"/>
    <dbReference type="SMR" id="A0A8C2T797"/>
    <dbReference type="Ensembl" id="ENSCJPT00005013798.1">
        <property type="protein sequence ID" value="ENSCJPP00005009213.1"/>
        <property type="gene ID" value="ENSCJPG00005008130.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107321898"/>
    <dbReference type="KEGG" id="cjo:107321898"/>
    <dbReference type="CTD" id="10439"/>
    <dbReference type="GeneTree" id="ENSGT00940000156959"/>
    <dbReference type="OrthoDB" id="8626508at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022082">
        <property type="entry name" value="Noelin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003112">
        <property type="entry name" value="Olfac-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050605">
        <property type="entry name" value="Olfactomedin-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23192:SF34">
        <property type="entry name" value="NOELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23192">
        <property type="entry name" value="OLFACTOMEDIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12308">
        <property type="entry name" value="Noelin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02191">
        <property type="entry name" value="OLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00284">
        <property type="entry name" value="OLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51132">
        <property type="entry name" value="OLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0770">Synapse</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034279798" evidence="11">
        <location>
            <begin position="17"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Olfactomedin-like" evidence="12">
        <location>
            <begin position="226"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="94"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="178"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="227"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005009213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="485" mass="55530" checksum="7B6481EAA497A948" modified="2022-01-19" version="1">MSVPLLKIGVVLSTMAMITNWMSQTLPSLVGLNTTKLTAASGGTLDRSTGVLPTNPEESWQVYSSAQDSEGRCICTVVAPQQTMCSRDARTKQLRQLLEKVQNMSQSIEVLDRRTQRDLQYVEKMENQMRGLESKFKQVEESHKQHLARQFKAIKAKMEELRPLIPVLEEYKADAKLVLQFKEEVQNLTSVLNELQEEIGAYDYEELQNRVSNLEERLRACMQKLACGKLTGISDPITIKTSGSRFGSWMTDPLAPEGENKVWYMDSYHNNRFVREYKSMADFMNTDNFTSHRLPHPWSGTGQVVYNGSIYFNKYQSHIIIRFDLKTETILKTRSLDYAGYNNMYHYAWGGHSDIDLMVDENGLWAVYATNQNAGNIVISKLDPNTLQSLQTWNTSYPKRSAGEAFIICGTLYVTNGYSGGTKVHYAYQTNASTYEYIDIPFQNKYSHISMLDYNPKDRALYAWNNGHQILYNVTLFHVIRSDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T7Y9</accession>
    <name>A0A8C2T7Y9_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Basic leucine zipper ATF-like transcription factor 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BATF3</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bZIP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T7Y9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005012649.1">
        <property type="protein sequence ID" value="ENSCJPP00005008311.1"/>
        <property type="gene ID" value="ENSCJPG00005007466.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161120"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043011">
        <property type="term" value="P:myeloid dendritic cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009615">
        <property type="term" value="P:response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000043">
        <property type="entry name" value="Basic leucine zipper transcriptional factor ATF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000837">
        <property type="entry name" value="AP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23351:SF13">
        <property type="entry name" value="BASIC LEUCINE ZIPPER TRANSCRIPTIONAL FACTOR ATF-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23351">
        <property type="entry name" value="FOS TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00042">
        <property type="entry name" value="LEUZIPPRFOS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="9">
        <location>
            <begin position="33"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005008311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="124" mass="13941" checksum="4573134980E383BE" modified="2022-01-19" version="1">MSCGAPAAGSAVPRSAEGGQQRAASAFQSHEEDDKKVRRREKNRVAAQRSRKKQTQKADKLHEEYESLEQENTSLKKEIGKLTDEMKHLSEVLKDHEKICPLLHCTMNFVTVPRPDALSSCLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T8V2</accession>
    <name>A0A8C2T8V2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutathione transferase</fullName>
            <ecNumber evidence="2">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC107312129</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily. Alpha family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="2"/>
    <dbReference type="RefSeq" id="XP_015714752.1">
        <property type="nucleotide sequence ID" value="XM_015859266.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015714753.1">
        <property type="nucleotide sequence ID" value="XM_015859267.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015714754.1">
        <property type="nucleotide sequence ID" value="XM_015859268.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015714755.1">
        <property type="nucleotide sequence ID" value="XM_015859269.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T8V2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005013459.1">
        <property type="protein sequence ID" value="ENSCJPP00005008951.1"/>
        <property type="gene ID" value="ENSCJPG00005007914.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107312129"/>
    <dbReference type="KEGG" id="cjo:107312129"/>
    <dbReference type="GeneTree" id="ENSGT00940000154526"/>
    <dbReference type="OrthoDB" id="414243at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03208">
        <property type="entry name" value="GST_C_Alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000005">
        <property type="entry name" value="Glutathione S-transferase A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003080">
        <property type="entry name" value="GST_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF107">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01266">
        <property type="entry name" value="GSTRNSFRASEA"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01205">
        <property type="entry name" value="AMPS.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00363">
        <property type="entry name" value="AMPS_(cytGST):_Alpha-__Mu-__Pi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="4">
        <location>
            <begin position="3"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="5">
        <location>
            <begin position="85"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005008951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="221" mass="25187" checksum="B7EFB8793A79E778" modified="2022-01-19" version="1">MSGKPVLHYVSVRGRMEPVKWLLAAAGVEFEEKFVETKEDLQKLRAGGSLLFQQIPMVEIDGMKLVQTRAILNYIAGKYNLYGKDLKERALIDMYVEGLADLNELIMYHDFKPANEKEKNLASIFDKAMNRYLPVFEKVLKDHGQDFLVGNKLSRADVNLLETILVLEEFKPDALAKFPVLQSFKARMCSMPNIKKFLQPGSPKKPPLQEKEIPALLAIFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T9S1</accession>
    <name>A0A8C2T9S1_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nuclear receptor coactivator 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">NCOA7</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OXR1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015714007.1">
        <property type="nucleotide sequence ID" value="XM_015858521.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015714008.1">
        <property type="nucleotide sequence ID" value="XM_015858522.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015714009.1">
        <property type="nucleotide sequence ID" value="XM_015858523.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T9S1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005015542.1">
        <property type="protein sequence ID" value="ENSCJPP00005010519.1"/>
        <property type="gene ID" value="ENSCJPG00005009148.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107311732"/>
    <dbReference type="KEGG" id="cjo:107311732"/>
    <dbReference type="CTD" id="135112"/>
    <dbReference type="GeneTree" id="ENSGT00940000155141"/>
    <dbReference type="OrthoDB" id="26679at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016922">
        <property type="term" value="F:nuclear receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900408">
        <property type="term" value="P:negative regulation of cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354:SF68">
        <property type="entry name" value="NUCLEAR RECEPTOR COACTIVATOR 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354">
        <property type="entry name" value="NUCLEOLAR PROTEIN 7/ESTROGEN RECEPTOR COACTIVATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="199"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="4">
        <location>
            <begin position="871"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="108"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="409"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="480"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="63"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="178"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="480"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005010519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1032" mass="115957" checksum="425DC101A1E2960C" modified="2022-01-19" version="1">METKEEKKERRQGYFARLKKKRQAKQNTETVSANSPGSPVSKTPTEKDDESKVILEQISSSEDNSKFAGEKETVPDKEKKKKKYNQLKDIRRTELKRYYSTELLVCTAEHPPGRQRPQGPATWSSGPGPAFSPLPPKPSCNTEGLGARRAAMHSLSTPRPRSWSWGCVPASPPSPDDNQNKTNEKKEKKMVSQKPHGTIEYTAGNQDTINSIALKFNITPNKLVELNKLFTHTIVPGQILFVPETSVARLPSFSPGAPISPSSSDAEYDKLPDADLARKALKPVERVLSSTSEEDEPVVVKFLKMNCRYFTDGKGVVGGVMIVTPNNIMFDPHKSDPLVIENGCEEYGLICPMEEVVSIALYNDISHMKIKDALPSDIPKDLCPLYRPGEWEDLSSEKDINPFSKFKSLSKEKRQQNGDSPNVPGAKQINPSDKEKSSDFEVLQSSESTGSIKSKSLEFYNNITATEHLEKFAADPLVKEPSEEKNVSDIRTKEDSLSGGGGDDFIDLEKVPSRMDRGLDRKISLMEGLLADPRELGRTKQQVTKPTTEVQEHFTVDSLEKKDSVEPKADLDLELCEKQDVIPEVNKCVSSPTGKVETALDTKKELEKDKLIEFYLNKDGSGSQSSEDLHKAEIQKGENNKAIGIDLTLSCSKSQADEVHTVRSMELDSCCVGRKAPSLESSAAAAEEKDLKESLDSSLVPAVDKTCQETQLDNQSEVRLWLLQKIQVPIEDMLPSKEEKSKTPPMFLCIKVGKPMRKSFVSQSTTMSQQYSKKIKQPEYWFAVPRERVDHLYTFFVQWSPEIYGKDAKEQGFVVVEKEELDMIDNFFSEPTTKSWEIITVEEAKRRKSVCSYYGEEEDDDALPVLKHHSALLENMHIEQLAQRLPARVQGYPWRLAYSTLEHGTSLKTLYRKSASLDSPVLLVIKDMDNQIFGAYATHPFKFSDHYYGTGETFLYTFSPNFKVFKWSGENTYFINGDMTSLELGGGGGRFGLWLDADLYHGRSNSCSTFNNDILSKKEDFIIQDVEVWTFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T9S7</accession>
    <name>A0A8C2T9S7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">CDC7</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2T9S7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005013950.1">
        <property type="protein sequence ID" value="ENSCJPP00005009335.1"/>
        <property type="gene ID" value="ENSCJPG00005008208.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00550000075011"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045171">
        <property type="term" value="C:intercellular bridge"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044770">
        <property type="term" value="P:cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010571">
        <property type="term" value="P:positive regulation of nuclear cell cycle DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd14019">
        <property type="entry name" value="STKc_Cdc7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000287">
        <property type="entry name" value="Cell division cycle 7-related protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF23">
        <property type="entry name" value="CDC7 KINASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="79"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="270"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005009335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="591" mass="65648" checksum="D639FC69C32251AF" modified="2022-01-19" version="1">MYYQVCLLPQVSRSGFQGLGCFFFSFVMETESKSHCDEQHPHQAEDTSRKHVQNSKLSAGIKKDIEKLYEAVPQLVNVFKIKEKIGEGTFSSVYLATVQLQSGCEEKMALKHLIPTSHPLRIAAELQCLTVAGGQDNVMGVKYCFRKNDHVVIVMPYLEHESFLDILNSLSFEEVKEYMFNLFKALRRIHHFGIVHRDVKPSNFLYNRRLKQYALVDFGLAQGTPDTKIELLKTAHSEGQQGSYSQSNPNTALGKGVSVSVTAPNQIAQQLASRASDKSSHSSSHSKIQIKQGRGGKEDSVHHSAQRSVFGERNFNIYCSTYQENSNTKLFKQSKVIDVSSRKLVTKKKIISTKAMSNGLGRKAASGCPSNLTCNCYATDRVCSVCLSRCQQVAPRAGTPGFRAPEVLTKCPTQTTAIDMWSAGIVFLSLLSGRYPFYKASDDLTALAQIMTVRGSRETIQAAKTFGKSVLCTQVVPAQNLRTLCEKLRGTNSSCNRSHCDVPCKSGDDSALPVEVDKQCAPEILRKETQHLKSCQEDDGASEDKATDMKGWDQVPDEAYDLLDKLLDLNPATRITAKDALLHPFFKDMRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TAX0</accession>
    <name>A0A8C2TAX0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">B-cell lymphoma/leukemia 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">B-cell CLL/lymphoma 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">BCL10</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="13">Homomultimer; homooligomerized following recruitment by CARD domain-containing proteins that form a nucleating helical template that recruits BCL10 via CARD-CARD interaction. Self-associates by CARD-CARD interaction and interacts with other CARD-proteins such as CARD9, CARD10, CARD11 and CARD14. Forms a complex with CARD14 and MALT1; resulting in the formation of a CBM (CARD14-BCL10-MALT1) complex. Forms a complex with CARD11 and MALT1; resulting in the formation of a CBM (CARD11-BCL10-MALT1) complex. Forms a complex with CARD9 and MALT1; resulting in the formation of a CBM (CARD9-BCL10-MALT1) complex. Found in a membrane raft complex, at least composed of BCL10, CARD11, DPP4 and IKBKB. Binds caspase-9 with its C-terminal domain. Interacts with TRAF2 and BIRC2/c-IAP2. Interacts with PELI2 and SOCS3; these interactions may be mutually exclusive.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane raft</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015725667.1">
        <property type="nucleotide sequence ID" value="XM_015870181.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TAX0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005014153.1">
        <property type="protein sequence ID" value="ENSCJPP00005009476.1"/>
        <property type="gene ID" value="ENSCJPG00005008315.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107317464"/>
    <dbReference type="KEGG" id="cjo:107317464"/>
    <dbReference type="CTD" id="8915"/>
    <dbReference type="GeneTree" id="ENSGT00940000167202"/>
    <dbReference type="OrthoDB" id="5984934at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032449">
        <property type="term" value="C:CBM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019209">
        <property type="term" value="F:kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051059">
        <property type="term" value="F:NF-kappaB binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043422">
        <property type="term" value="F:protein kinase B binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001238">
        <property type="term" value="P:positive regulation of extrinsic apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08810">
        <property type="entry name" value="CARD_BCL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.533.10:FF:000022">
        <property type="entry name" value="B-cell lymphoma/leukemia 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033238">
        <property type="entry name" value="BCL10/E10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001315">
        <property type="entry name" value="CARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042143">
        <property type="entry name" value="CARD_BCL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34920">
        <property type="entry name" value="B-CELL LYMPHOMA/LEUKEMIA 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34920:SF1">
        <property type="entry name" value="B-CELL LYMPHOMA_LEUKEMIA 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00619">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50209">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="11" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="7" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0391">Immunity</keyword>
    <keyword evidence="6" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="CARD" evidence="17">
        <location>
            <begin position="20"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="198"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="205"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00064168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00068591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00077472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005009476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="244" mass="27009" checksum="7D0A38FF3C6CE74D" modified="2022-01-19" version="1">MDGSGPASSAVGRPLTEDEMADVKKEALERMRPYLCDKIIAERHFDYLRSKKILTREDTEEISSRSSSRKKTGKLLDYLAENPKGLDALVESIRRERTQNFLLQKITDIVLKVKNEKLEALKGLSCSTCMTSLYGGTNNLSRSYSDESNFFDKTKDKESTQMHNPEEDYSTAAFMSAVSLHSMNLPVAEMGSAESAVLSVTLPGPGDPGAPPLPPELQSEQQEPCTSSSDNCFLPLRSRSLHPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TE33</accession>
    <name>A0A8C2TE33_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Homeobox protein cut-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">CUX1</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the CUT homeobox family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSCJPT00005016515.1">
        <property type="protein sequence ID" value="ENSCJPP00005011274.1"/>
        <property type="gene ID" value="ENSCJPG00005009330.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159751"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.40:FF:000004">
        <property type="entry name" value="Cut-like homeobox 1a"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.40:FF:000010">
        <property type="entry name" value="Cut-like homeobox 1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000116">
        <property type="entry name" value="Cut-like homeobox 2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003350">
        <property type="entry name" value="CUT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057476">
        <property type="entry name" value="Cux_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043">
        <property type="entry name" value="CCAAT DISPLACEMENT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043:SF4">
        <property type="entry name" value="HOMEOBOX PROTEIN CUT-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02376">
        <property type="entry name" value="CUT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25398">
        <property type="entry name" value="CUX1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01109">
        <property type="entry name" value="CUT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51042">
        <property type="entry name" value="CUT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 11 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 11 12" id="KW-0371">Homeobox</keyword>
    <keyword evidence="10 11 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 13" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CUT" evidence="17">
        <location>
            <begin position="542"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="CUT" evidence="17">
        <location>
            <begin position="928"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="domain" description="CUT" evidence="17">
        <location>
            <begin position="1111"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="16">
        <location>
            <begin position="1236"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="11">
        <location>
            <begin position="1238"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="395"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="512"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="647"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="682"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="836"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1031"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1204"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1305"/>
            <end position="1507"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="101"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="395"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="431"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="516"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="652"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="688"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="836"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="862"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="881"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="904"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1031"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1044"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1061"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1211"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1222"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1305"/>
            <end position="1326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1338"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1354"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1430"/>
            <end position="1452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1470"/>
            <end position="1494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005011274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1530" mass="168134" checksum="27FD38B830E2BCDE" modified="2022-01-19" version="1">QLCVAQASSPRELDATATILANRQDESEQSRKKLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDALGKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRMHDIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAENIALEKEQKLQNDFAEKERKLQETQMSTASKLEEAEHKVQALQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSANKSLQLATQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQGSLTKLRENSSSQISQLEQQLTAKNSTLKQLEEKLKGQADYEEVKKELNILKSMEFAPPESSGAQDASKPLEVLLLEKNRSLQSENATLRITNSDLSGSARRKGKDQPESQRPATLPASPPSQLLRNAGEQASNTNGTHQFSPTGLSQDFFSSSLASPSLPLASTGKFALNSLLQRQLMQSFYSKAMQEAGSTSMIFSTGPYSTNSISSQSPLQQSPDVNGMAPSPSQSESAGSISEGEEIDTAEIARQVKEQLIKHNIGQRIFGHYVLGLSQGSVSEILARPKPWNKLTVRGKEPFHKMKQFLSDEQNILALRSIQGRQRENPGQNLNRLFQEVPKRRNGSEGNITTRIRTTETGSDEAIKSILEQAKRELQVQKTAEPAQPPSASSSGNSDDAIRSILQQARREMEAQQAALDPALKTTPLSQADISILSPKLVSTSAMSSVSSYPPLAISLKKHSSVTDSSISALQNLSGLKKEPQEAPVLELHGISDSAQGMLRHVKNELGRGGVWKDHWWNTVQHERRNAALPEDIKVEEASGGKEKVSNQTRPDRSQLQGPSSSEYWKEWPNAESPYSQSSELSMTGASRSETPQNSPLPSSPIVSLSKPSKPSVPPLTPEQYEIYMYQEVDTIELTRQVKEKLAKNGICQRIFGEKVLGLSQGSVSDMLSRPKPWSKLTQKGREPFIRMQLWLNGELGQCVLPAQGQQQGQVLHSVTSLQDSLQQGCASSESTPKTSASCSPAPESPMSSSESVKSLTELVQQPCPSIETSKDGKAQEPNEPPASESQSTTPLPLSGHSALSIQELVAMSPELDTYGITKRVKEVLTDNNLGQRLFGETILGLTQGSVSDLLARPKPWHKLSLKGREPFVRMQLWLNDPNNVEKLMDMKRMEKKAYMKRRHSSVSDSQSCESSSTGIDYSQGASPQPQHQLKKPRVVLAPEEKEALKRAYQQKPYPSPKTIEELATQLNLKTSTVINWFHNYRSRIRRELFIEEIQAGSQSQAGSSDSPSARSSRAAHSSEGDSCDGVDAEGPPEGKPSGPEADEYSNATTKSQGGQAESALEVGEEAAPGARPTERGEQGEPLLAAAEGLEDTDDEGRPRAPRHGSPTGCQRSGEAPETLPSSGTEGDASTSAASTSVLTGESSYKSKDSEKSSSVPSTSSTPGAGSQKANSLQSLFSFSEAASSRNTRDSSLRKKKAANLNNIIHRLEKAASREEAAEWEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TE75</accession>
    <name>A0A8C2TE75_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Family with sequence similarity 193 member B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">FAM193B</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM193 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TE75"/>
    <dbReference type="Ensembl" id="ENSCJPT00005017039.1">
        <property type="protein sequence ID" value="ENSCJPP00005011666.1"/>
        <property type="gene ID" value="ENSCJPG00005010013.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000000973"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029717">
        <property type="entry name" value="FAM193"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031802">
        <property type="entry name" value="FAM193_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15109">
        <property type="entry name" value="AGAP004327-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15109:SF3">
        <property type="entry name" value="PROTEIN FAM193B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15914">
        <property type="entry name" value="FAM193_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM193 C-terminal" evidence="5">
        <location>
            <begin position="1002"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="15"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="100"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="242"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="289"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="375"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="507"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="607"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="640"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="828"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="121"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="289"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="420"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="454"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="540"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="554"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="651"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="662"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="935"/>
            <end position="955"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF15914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005011666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1058" mass="111933" checksum="08D9358FE696A8F4" modified="2022-01-19" version="1">MSRVTAERCGIVRGTALRPASPRGAPRVFAASGPGEAPPPPTARGRRYRAAPPALKMAAAASPPRAAPPRAGAGRAAPPYWLLSCVRRAALAMTRRRNKVAAAGAAGNRRERPGGAAGTTPAPPPPPPPPPEPPSPTEAAVSAGGSAEPGRAAPQVLPTANQSVQTCCLLCHRERKDWGGPSHNGLVSPGERLPPDFVPTLVQNLLGEMPLWICQSCRKSVEEEERRAVQEQALAVSLSHTSCKSQSCGGGSHSSSSSTSSSSSSCHGNSGDWDPSSFLSAHKLSGLWNSQHTNGATQGSPLGAPPAALGDKHPSLALSPECISQAPATVAGLKACPYGHATSPATGSAAPGSPLPTSLDFCKTLPKQFKSMCRRATPPGEAFHSSEHHQHSDLTAPPNSPTGLPSQPPALIPSKQMPAHPGPFGSPPHVPLGTTPQAALFPAPSVQTAALKPTSESPSAGTVSHSPGSCKSPHLPPANVPLLKMPPPLSGCTHPCNGHCSTSLIPPPASHQLPGTNRDPSCKGHKFPNGTSCHPPQPCEADEGLGEDEDSSSERSSCTSSSTNQKDGKFCDCCYCEFFGHNAPPAAPTSRNYAEIREKLRSRLTKRKEELPQKLGHNSSSGEPAVDHRNVDELLDYINSTEPKPLNSAKAAKRARHKQKKKEKEKAQLEAEAQKRAERAPANSQNREPAEEKLLEWPELELERVNSFLSSRLQEIRNTIKDSIRASFSVYDLNLDVNDFPKKAAVLEQKNLISHLNGSSDLQDIDLALAPLSLGPTKSHSLLRGELGPRWGDGPGELPLAPTATENGVVKRLSAVPSLSRMIWVQSKAADSAVDGDGQSPEPKEGPQPKGPEPQEQVQAGGRQRKNKRQSGQVKKGDGAVVLSGQARLENSGVKGQVLGTKHPSKPSTAELQRAGGCTEVESGKGQPWGCSTARAEKEKSNDWKGRRAEGKAELPDLVQLPTPANGDRQLPPPAALGGSPQPKGKSRKNRNKVEKPNTSIDDVFLPKDLDGAEMDETDREVEYFKRFCLDSAKQTRQKVAVNWTNFTLKKTTSSAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TEM4</accession>
    <name>A0A8C2TEM4_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Serine/threonine-protein kinase PLK</fullName>
            <ecNumber evidence="20">2.7.11.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Polo-like kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">PLK3</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17 20">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.21"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="20">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.21" evidence="20"/>
    <dbReference type="RefSeq" id="XP_015725822.1">
        <property type="nucleotide sequence ID" value="XM_015870336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TEM4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005016600.1">
        <property type="protein sequence ID" value="ENSCJPP00005011351.1"/>
        <property type="gene ID" value="ENSCJPG00005009751.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107317517"/>
    <dbReference type="KEGG" id="cjo:107317517"/>
    <dbReference type="CTD" id="1263"/>
    <dbReference type="GeneTree" id="ENSGT00940000159121"/>
    <dbReference type="OrthoDB" id="408964at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002039">
        <property type="term" value="F:p53 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090166">
        <property type="term" value="P:Golgi disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044819">
        <property type="term" value="P:mitotic G1/S transition checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904716">
        <property type="term" value="P:positive regulation of chaperone-mediated autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090316">
        <property type="term" value="P:positive regulation of intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032436">
        <property type="term" value="P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010646">
        <property type="term" value="P:regulation of cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032465">
        <property type="term" value="P:regulation of cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023051">
        <property type="term" value="P:regulation of signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006970">
        <property type="term" value="P:response to osmotic stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009314">
        <property type="term" value="P:response to radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd13118">
        <property type="entry name" value="POLO_box_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13117">
        <property type="entry name" value="POLO_box_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14189">
        <property type="entry name" value="STKc_PLK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000189">
        <property type="entry name" value="Serine/threonine-protein kinase PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1120.30:FF:000001">
        <property type="entry name" value="Serine/threonine-protein kinase PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000091">
        <property type="entry name" value="Serine/threonine-protein kinase PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.30">
        <property type="entry name" value="POLO box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042703">
        <property type="entry name" value="PLK3_STKc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033701">
        <property type="entry name" value="POLO_box_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033695">
        <property type="entry name" value="POLO_box_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000959">
        <property type="entry name" value="POLO_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036947">
        <property type="entry name" value="POLO_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF42">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PLK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00659">
        <property type="entry name" value="POLO_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82615">
        <property type="entry name" value="Polo-box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50078">
        <property type="entry name" value="POLO_BOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="12 19 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 19 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 20" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6 20" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="22">
        <location>
            <begin position="81"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="POLO box" evidence="23">
        <location>
            <begin position="496"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="POLO box" evidence="23">
        <location>
            <begin position="594"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="44"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="21">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU361162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005011351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="679" mass="76257" checksum="FD1754FD1CF1C15E" modified="2022-01-19" version="1">MAPIDKAGRDPRRGNGSARWLRATCAGRGGGGAAAMEHNGLFPPLLSTRLPAPPAHGPAPPSARPAEPTRIITDPLSGRSYCKGRLLGKGGFARCYEMTDLSSNKTYAVKVIPHSRVAKPHQREKITNEIELHRDLHHKHIVKFSHYFEDAESIYIFLEHCSRKSLAHIWKARHTLLEPEVRYYLKQIISGLKYLHLKGILHRDLKLGNFFINENMELKVGDFGLAAYQDASDQKKKTICGTPNYLAPEVLLRQGHGPESDVWSLGCVMYTLLCGNPPFETLDLKETYRYIKQVDYILPTFLSLPARHLIAGILKRNPQDRLTLDEILDHEFFKGYTPEKLPPSSCVIAPELCAPNPAKSLFAKVTKTLFRKKKPKAKKGSLEDKDDISKLVTGLVKTSICRQMSCKAVEGNEATPMYCRSAGSSPVETLVEETSRKSTSPSVRGTMASSCEAFEDCITTSAIIESAVQLLRTCLSCMPPAERNPASLARHEQFVWVSKWVDYSNKYGFGYQLSNHSIGVLFNNGTHMMLSPNHKTVHYNPTNSKHFAFPVSAVPEQLRGQMSVLRYFASYMEQHLMKGGDLPSIDDLGQPALLLLQWVKTDQALLMLFSNGTLQVNFYNDHTKVIISKPDRSCLVTYINRERNSYTYKLCSIQELGCSPELQRCLRYILKLLQEWADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TFA1</accession>
    <name>A0A8C2TFA1_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Suppressor of cytokine signaling 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">SOCS5</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015713018.1">
        <property type="nucleotide sequence ID" value="XM_015857532.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TFA1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005017310.1">
        <property type="protein sequence ID" value="ENSCJPP00005011885.1"/>
        <property type="gene ID" value="ENSCJPG00005010163.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107311191"/>
    <dbReference type="KEGG" id="cjo:107311191"/>
    <dbReference type="CTD" id="9655"/>
    <dbReference type="GeneTree" id="ENSGT00940000159000"/>
    <dbReference type="OrthoDB" id="8820570at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005942">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046935">
        <property type="term" value="F:1-phosphatidylinositol-3-kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005154">
        <property type="term" value="F:epidermal growth factor receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030971">
        <property type="term" value="F:receptor tyrosine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007259">
        <property type="term" value="P:cell surface receptor signaling pathway via JAK-STAT"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071404">
        <property type="term" value="P:cellular response to low-density lipoprotein particle stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019221">
        <property type="term" value="P:cytokine-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007173">
        <property type="term" value="P:epidermal growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050728">
        <property type="term" value="P:negative regulation of inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032715">
        <property type="term" value="P:negative regulation of interleukin-6 production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071638">
        <property type="term" value="P:negative regulation of monocyte chemotactic protein-1 production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009968">
        <property type="term" value="P:negative regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045629">
        <property type="term" value="P:negative regulation of T-helper 2 cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032436">
        <property type="term" value="P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045627">
        <property type="term" value="P:positive regulation of T-helper 1 cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097699">
        <property type="term" value="P:vascular endothelial cell response to fluid shear stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd03739">
        <property type="entry name" value="SOCS_SOCS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000028">
        <property type="entry name" value="Suppressor of cytokine signaling 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022252">
        <property type="entry name" value="SOCS4/SOCS5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037343">
        <property type="entry name" value="SOCS5_SOCS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036036">
        <property type="entry name" value="SOCS_box-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10155">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10155:SF15">
        <property type="entry name" value="SUPPRESSOR OF CYTOKINE SIGNALING 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12610">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00253">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158235">
        <property type="entry name" value="SOCS box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0341">Growth regulation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="3" id="KW-0734">Signal transduction inhibitor</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SH2" evidence="8">
        <location>
            <begin position="381"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="9">
        <location>
            <begin position="471"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="116"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005011885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="536" mass="61299" checksum="ED688D6BDCBFEA75" modified="2022-01-19" version="1">MDKVGKMWNNFKYRCQNLFSHEGGSQNENIVVNSSSCSSAKDRTVQITGLAQQQPSSPLRENIALQLGLSPSKNSVRRNQNCVTEIPQIVEISIEKENDSCVTTGTRLARRDSYSRHAPWGGKKKHSCSTKTQSSLDTEKRFGRTRSGLQRRERRYGVSSVHDMDAVSNRTVGSRSLRQRLQDTVGLCFPMRTYSKQSKPLFSNKRKIHLSELMLEKCPFPAGSDLAQKWHLIKQHTAPVSPHSTFFDTFDPSLVSTEDEEDRLRERRRLSIEEGVDPPPNAQIHTFEATAQVNPLYKLGPKLAPGMTELAGDKNATPPGNCDSEEDTTTLCLQSRRQKQRQMSGESHGHISKQGAWKVHTQIDYIHCLVPDLLQITGNPCYWGVMDRYEAEALLEGKPEGTFLLRDSAQEDYLFSVSFRRYNRSLHARIEQWNHNFSFDAHDPCVFHSSTVTGLLEHYKDPSSCMFFEPLLTVSLNRTFPFSLQYICRAVICRCTTYDGIDDLPLPSMLQDFLKEYHYKQKVRVRWLEREPIKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2THT5</accession>
    <name>A0A8C2THT5_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ADP-ribosylation factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ARF1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015708477.1">
        <property type="nucleotide sequence ID" value="XM_015852991.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015708479.1">
        <property type="nucleotide sequence ID" value="XM_015852993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2THT5"/>
    <dbReference type="SMR" id="A0A8C2THT5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005017955.1">
        <property type="protein sequence ID" value="ENSCJPP00005012393.1"/>
        <property type="gene ID" value="ENSCJPG00005010537.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107308830"/>
    <dbReference type="KEGG" id="cjo:107308830"/>
    <dbReference type="CTD" id="375"/>
    <dbReference type="GeneTree" id="ENSGT00950000183080"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031252">
        <property type="term" value="C:cell leading edge"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030017">
        <property type="term" value="C:sarcomere"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098586">
        <property type="term" value="P:cellular response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990386">
        <property type="term" value="P:mitotic cleavage furrow ingression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04150">
        <property type="entry name" value="Arf1_5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003500">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045872">
        <property type="entry name" value="Arf1-5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 14" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10 14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 14" id="KW-0519">Myristate</keyword>
    <keyword evidence="5 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU369003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005012393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="181" mass="20697" checksum="AAC773D4A60186B6" modified="2022-01-19" version="1">MGNIFANLFKGLFGKKEMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKNISFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRERVNEAREELMRMLAEDELRDAVLLVFANKQDLPNAMNAAEITDKLGLHSLRHRNWYIQATCATSGDGLYEGLDWLSNQLRNQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TI22</accession>
    <name>A0A8C2TI22_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Metal transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC107323633</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Metal transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cell membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the ACDP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015738407.1">
        <property type="nucleotide sequence ID" value="XM_015882921.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TI22"/>
    <dbReference type="Ensembl" id="ENSCJPT00005020239.1">
        <property type="protein sequence ID" value="ENSCJPP00005014171.1"/>
        <property type="gene ID" value="ENSCJPG00005011855.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107323633"/>
    <dbReference type="KEGG" id="cjo:107323633"/>
    <dbReference type="GeneTree" id="ENSGT00940000156317"/>
    <dbReference type="OrthoDB" id="5353557at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015081">
        <property type="term" value="F:sodium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010960">
        <property type="term" value="P:magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.580.10:FF:000001">
        <property type="entry name" value="Putative metal transporter CNNM3 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045095">
        <property type="entry name" value="ACDP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057492">
        <property type="entry name" value="Ig_CNNM1/2/4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064">
        <property type="entry name" value="METAL TRANSPORTER CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064:SF26">
        <property type="entry name" value="METAL TRANSPORTER CNNM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25562">
        <property type="entry name" value="CNBH_CNNM2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25511">
        <property type="entry name" value="Ig_CNNM4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="206"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="16">
        <location>
            <begin position="202"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="15">
        <location>
            <begin position="469"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="745"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="754"/>
            <end position="763"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU369091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005014171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="799" mass="87248" checksum="449C664C4DDFC8DC" modified="2022-01-19" version="1">MAAGGGRRRGGTGSNTGTGSSTGTGRSSAASPPPLLPPLLLLLALPGGSAVGGGDSVILGMRLEESTKPAAPTRGPIRVTEGSELLLRLYGFGLGPGTGQRVAFAELRPVGNASIHNGTCPERSQDLVVQGLVGTEQTGGDTGGDTGGTEDTSALLRVRVQPLRKDEQAKTYVLCTQRRPGLPWLLHRGADGHIVVVEEKKSLLPLWLQVILIVGLLVLSGIFSGLNLGLMALDPMELRIVQNCGTDKEKRYARKIEPIRRKGNYLLCSLLLGNVLVNTTLTILLDDLIGSGIGAVAASTIGIVIFGEIVPQALCSRHGLAVGANTIVLTKIFMLVTFPLSYPISKLLDFILGQEIGTVYNREKLVEMLKVTEPYNDLVREELNMIQGALELRTKTVEDVMTPLRNCFMISSDAILDFNTMSEIMESGYTRIPVYEEDRSNIVDLLFVKDLAFVDPDDCTPLKTITRFYNHPLHFVFNDTKLDAMLEEFKKGKSHLAIVQRVNNEGEGDPFYEVLGIVTLEDVIEEIIKSEILDETDAFAAEENRSKKRTGNQKGKRDFSAFKDPVNEQKVKVSPQLLLAAHRFLSTEVTLFTPNFISEKILLRLLKYSDVIQELKFDEENKRSPHHFLYTKNKAADYFILILQGKVEVEAGKECMKFEAGAFSYYGVMAISPPPVSETRSPSHVSGLNRSASLCHERSDSVSSPVGGSNNQLSPAAPYVADFSVRALTDLQFVKITRQEYQNGLTTSRMDSCPQSPDSGSPKPDGPEKTEPADETTSLLNERNCLGRRSTHGPIENSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TJF7</accession>
    <name>A0A8C2TJF7_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TJF7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005019262.1">
        <property type="protein sequence ID" value="ENSCJPP00005013400.1"/>
        <property type="gene ID" value="ENSCJPG00005011310.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158845"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052231">
        <property type="entry name" value="Rho_GEF_signaling-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45845:SF4">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN CONTAINING, FAMILY G (WITH RHOGEF DOMAIN) MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45845">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="614"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="684"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="617"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005013400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="788" mass="85019" checksum="0982838FFCC72A74" modified="2022-01-19" version="1">MGALYPPFEATAATVLCQVFDVVEKTYRGDGLRYLIDFLIPAKHILQCIQQDACVQYCGLLFRHEGWPLCIHEKIVVQLASIDWRILKPGDFYLQVVPYLKKSPRIVLKCLAKDKHNVEEVVIPEVSYTSIFTLEWLSTINGERMGIALENCLLTTDEKIFRVPWDNVVNPEFINKPKITENNIITPETAGKPSLFAVPEEDLQSDLEGEYVELAQVSLPRFGPQTGSLTQSVALNYLTQPRTRVNASKGKHRFIVIQDSTYSKNSVHSALMQKEHCQMDALSSSPEALKNVIPLESNETTACEELCPEGQLLPGGPGSMGNSSPATAAPSCSVEEQEACSEGSVDWQYAPCSSDDVCAGDGVSCKAQMTGSTGNMELESDGSSINPGVEILERSPEANLGAAAEEEVMEEHGELLTEHQHEVTQVDPSLGSVLEPLGPHCTLKEGPNDSCQSASECAAPVQATALPATPESSAVGVERGSPSGNMTDAAAVRACCADQETNCSSPVNPPEQLNREVGEIVVGRRESPEDIEEIEQVQAGKEHESSCSCCSTSAPVDGVLPDGEEQEVPACQCKEAEDTALLQTALPAECEQVAEQPGTSGSSLGLDAQAEDLSEFGSHRSEERCGDPQGWTGNQGHGSEMNSVLNPEGVLAQDLQGEGENQDSCSDVDRSKAVALTTLESIEEELEVGPLSSGPAEGNMEPTALHSHPEADPEASSPKGTGCLCIYLTDNIGRKRSAWELLLTSTRRLWDNSTSHREVIRFLHGFLFKGGFIAVKVDLLQYFVPQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TJS1</accession>
    <name>A0A8C2TJS1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phospholipid scramblase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">PLSCR5</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the phospholipid scramblase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TJS1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005021259.1">
        <property type="protein sequence ID" value="ENSCJPP00005014975.1"/>
        <property type="gene ID" value="ENSCJPG00005012447.1"/>
    </dbReference>
    <dbReference type="KEGG" id="cjo:107318199"/>
    <dbReference type="GeneTree" id="ENSGT00940000161728"/>
    <dbReference type="OrthoDB" id="444338at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017128">
        <property type="term" value="F:phospholipid scramblase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005552">
        <property type="entry name" value="Scramblase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23248:SF25">
        <property type="entry name" value="PHOSPHOLIPID SCRAMBLASE FAMILY MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23248">
        <property type="entry name" value="PHOSPHOLIPID SCRAMBLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03803">
        <property type="entry name" value="Scramblase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0564">Palmitate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005014975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="263" mass="29620" checksum="537230B59EBAF1A6" modified="2022-01-19" version="1">MASQDSQGQTNPVFKDYLPGSSDLPEQDKPTEPAGLWKQASDMHNLPPGLEYLKQLDRIIIHQQVELLEAILGTETCSKYEIKNHLGQRVYFAVEENGFFNRNLCSPIRSFTIRIADNSGREVITVNRPLRCNSCWFPCFLQELEVQSPPGTVAGYVVQNWDPFLPKFTIQNESKEDVLKIIGPYATCGCFDDVDFEVKALNEMSTIGKISKYWSGFVNNVFTNTANFGIQVPVDLDVKIKAVMIGACFLIDLMFFENSLDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TKE6</accession>
    <name>A0A8C2TKE6_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">SIK3</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 21">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 21">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005018699.1">
        <property type="protein sequence ID" value="ENSCJPP00005012978.1"/>
        <property type="gene ID" value="ENSCJPG00005010972.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157259"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050321">
        <property type="term" value="F:tau-protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060351">
        <property type="term" value="P:cartilage development involved in endochondral bone morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001958">
        <property type="term" value="P:endochondral ossification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035108">
        <property type="term" value="P:limb morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035264">
        <property type="term" value="P:multicellular organism growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032880">
        <property type="term" value="P:regulation of protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd14071">
        <property type="entry name" value="STKc_SIK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14410">
        <property type="entry name" value="UBA_SIK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000156">
        <property type="entry name" value="Serine/threonine-protein kinase SIK3 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034672">
        <property type="entry name" value="SIK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057380">
        <property type="entry name" value="UBA_SIK1/2/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF42">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SIK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23312">
        <property type="entry name" value="UBA_SIK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="40"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="18">
        <location>
            <begin position="318"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="887"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1013"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1246"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="663"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1019"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005012978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1311" mass="145759" checksum="C5F9D6D76EDFBDCB" modified="2022-01-19" version="1">MAAAAAAAAASGAGGPPPAPRLPPAPPPPRPPGPARIGYYEIERTIGKGNFAVVKLATHLVTRAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVAAVNFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNIFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPSKRLSMDQICKHKWMKLGEADAEFDRLIAECQHLKTERQMEPLNEDVLLAMAEMGLDKERTIQSLRADAYDHFSAIYSLLCDRLKRHKNLRIAPSPSIPRTVTFPTSANIQTEQAGNTMNINVPQVQLINPENQIVETDGTMNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPRVTPQAPFLQVTPNVNFMHNVLPRQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQRYLANRSKRHTLAMTNPTAEIPPDLQRQLGQQSFRPRAWAPHLVPDQHRSIYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGHMDERTLEKTQQQHMLYQQEQHHQILHQQIQDCIRPPQPSPPLQAQCENQNGFSKSLFLVGAASQSQFQGMPSHNTIFPQSGNCSPPPTMGLTCLAMQQQSQAQQVTIQVQEPGDMVSNNLLQGASVAGQGMSSHTRGMSISPSANQIQMQHRANLMASLTYGHRQLSKQLSADSAESHSLNVYRNPPANYDQVHLHPHLFPEQPRVSPSNYSPSGGVGFPPAQQALKVPQLDQYPNFPQNAHQQQQHYTASALQQALLSPTPPDYSRHQQVPHILQGLLSPRHSLTGHTDMRLPQAEFAQLIKRRQQQQQQQQQQEFQELFRHMNQGDAGNMGTSMGQSLSERQSLSLPYQSADAYHPQNSPQHLLKIRAQECIQQVPASVPPHGYGHQPALFQSESMEEDCACEGARDSFPDSKNSNTLTKGCHETPLLVNAGGHGDPESLLGTANHVQELGTHQYRHQPAAGFSRNKVPSRESVVGNCMDRSSPGQAMQVPDHNGLGYPARPASSEHPRPRTLQRHHTIQNSDDAYVQLDNLPGMSLMAGKALSSARMSDAVLSQSSLMASQQLRDRESEECGESLEGQEHPNLGDGNQHLNTSCYPSTCITDVLLSYKHPEVPFGMEQAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TNK7</accession>
    <name>A0A8C2TNK7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Anoctamin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ANO6</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the anoctamin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015710403.1">
        <property type="nucleotide sequence ID" value="XM_015854917.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TNK7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005022958.1">
        <property type="protein sequence ID" value="ENSCJPP00005016314.1"/>
        <property type="gene ID" value="ENSCJPG00005013420.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107309816"/>
    <dbReference type="KEGG" id="cjo:107309816"/>
    <dbReference type="CTD" id="196527"/>
    <dbReference type="GeneTree" id="ENSGT00940000158969"/>
    <dbReference type="OrthoDB" id="296386at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005229">
        <property type="term" value="F:intracellularly calcium-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017128">
        <property type="term" value="F:phospholipid scramblase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002543">
        <property type="term" value="P:activation of blood coagulation via clotting cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032060">
        <property type="term" value="P:bleb assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061590">
        <property type="term" value="P:calcium activated phosphatidylcholine scrambling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061589">
        <property type="term" value="P:calcium activated phosphatidylserine scrambling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070588">
        <property type="term" value="P:calcium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045794">
        <property type="term" value="P:negative regulation of cell volume"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097045">
        <property type="term" value="P:phosphatidylserine exposure on blood platelet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046931">
        <property type="term" value="P:pore complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030501">
        <property type="term" value="P:positive regulation of bone mineralization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000353">
        <property type="term" value="P:positive regulation of endothelial cell apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034767">
        <property type="term" value="P:positive regulation of monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090026">
        <property type="term" value="P:positive regulation of monocyte chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035590">
        <property type="term" value="P:purinergic nucleotide receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035725">
        <property type="term" value="P:sodium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032394">
        <property type="entry name" value="Anoct_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007632">
        <property type="entry name" value="Anoctamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049452">
        <property type="entry name" value="Anoctamin_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308:SF21">
        <property type="entry name" value="ANOCTAMIN-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16178">
        <property type="entry name" value="Anoct_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04547">
        <property type="entry name" value="Anoctamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="302"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="464"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="511"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="559"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="675"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="726"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="829"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin dimerisation" evidence="11">
        <location>
            <begin position="70"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin transmembrane" evidence="10">
        <location>
            <begin position="291"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="10"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU280814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005016314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="914" mass="106363" checksum="C876257B97B416D2" modified="2022-01-19" version="1">MQADNPDVLLDLEEEGEGDEEVDEEVDEEDGESVLELNQVIIPTYGTVPDQQNLHTPEWADFDNKPDSLFFSDGQRRIDFVLVYEDETKMTHKRSNHKKQKRKRQVYESNLINNGLQLEATRSVLDEKTIFVKVHAPWEVLCTYAEVMHIKLPLQPNDLKTRESAFNWFTRLFRVNENIIKPEQEFFTAPFKREHLSNFYIQDKDTFFNPATRSRIVHFILSRVKYATKNVKKFGINKLLDTGIYKAAFPLHDSSFRHLSTDPECPSERYLLYREWAHPKNILKLQPLDFIRKYYGEKIGIYFAWLGFYTNMLIVAAVVGVGCFLYGFFMKDNCTWSQEVCDPSIGGNIIMCPQCDKVCTYWNLNITCESSKKLCIFDSFGTLVFAVFMGIWVTLFLEFWKRRQAELEYEWDTVEYLEQEEQIRPEYEAQCTHVVVNEITQQEEHVPYTACGKCMRITLCTSAVLFWILLIIASVIGIIVYRLSVFLVFSATLPRHVNGTQAIRKYLTPQTATSVTASIISFIVIMVLNIIYEKVAILITDFELPRTQTEYENSLTTKMFLFQFVNYYSSCFYIAFFKGKFVGYPGNPVYWLGKYRNEECDPGGCLLELTTQLAIIVGGKAIWNNIQEVLLPWVKNLIGRYCADARSEKIVPRWEQDYHLQPIGKLGLFYEYLEMVIQFGFVTLFVASFPLAPLLALINNMLEIRLDAWKLTTQFRRMVPQKAQDIGAWQPIMQGIAILAVVTNAMIIAFTSDMIPRLVYYWSFSVPPYGSHSSYTMKGYINNTLSVFNISDFKDVSKPLSPLFGNYTTCRYRDFRYPPGHQHQYEHNIYYWHVIAAKLAFIIVMEHVIYFVKFIISYIIPDVSQEIKSKVKREKYLTQKILHENDLKVVKKTIGKIADKIIEGVDSTFRPKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TP91</accession>
    <name>A0A8C2TP91_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Arginyl aminopeptidase like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">RNPEPL1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015727062.1">
        <property type="nucleotide sequence ID" value="XM_015871576.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TP91"/>
    <dbReference type="Ensembl" id="ENSCJPT00005023465.1">
        <property type="protein sequence ID" value="ENSCJPP00005016747.1"/>
        <property type="gene ID" value="ENSCJPG00005013738.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107318139"/>
    <dbReference type="KEGG" id="cjo:107318139"/>
    <dbReference type="CTD" id="57140"/>
    <dbReference type="GeneTree" id="ENSGT00940000160400"/>
    <dbReference type="OrthoDB" id="79562at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09599">
        <property type="entry name" value="M1_LTA4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000003">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.320:FF:000001">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2010.30:FF:000001">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.320">
        <property type="entry name" value="Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049980">
        <property type="entry name" value="LTA4H_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038502">
        <property type="entry name" value="M1_LTA-4_hydro/amino_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034015">
        <property type="entry name" value="M1_LTA4H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015211">
        <property type="entry name" value="Peptidase_M1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45726:SF2">
        <property type="entry name" value="AMINOPEPTIDASE RNPEPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45726">
        <property type="entry name" value="LEUKOTRIENE A-4 HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09127">
        <property type="entry name" value="Leuk-A4-hydro_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01263">
        <property type="entry name" value="Leuk-A4-hydro_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M1 leukotriene A4 hydrolase/aminopeptidase C-terminal" evidence="10">
        <location>
            <begin position="592"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="15"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="418"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="506"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="417"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="421"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="440"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR634015-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR634015-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005016747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="781" mass="85398" checksum="9C5AA99800F637DF" modified="2022-01-19" version="1">MAAPAPRPPGLCCCRKGSAGGPEAPPAPPPPPPDPPPPPDVASASSSQLFALRHLHLGLELRPEARALAGCLVLELCALRPQPCALVLDVHPALRVLSAAFRRAPPGEAPCSFAFSPAEAASSSSSSSAAPAPPPPPPPPPPCAPPPPPCSAAAAPCTATFLSAPCIAAPPSEPPAGHPPLAEPPLPRFSRPPAASCPLGFRVDPFTDYGSALTLSLPAALQPHQPFQVIVRYTTADGPAIWWLDPELTYGNTKPFVFTQGHSVCNRSFFPCFDTPAVKCTYSATVKAPAGMQVLMSATQSTFLEDEGVYQFYMEYPVPAYLVALVAGDLIHADIGPRSRVWAEPCLLPTAISKLSGMVERWLTAAESLYGPYIWGRYDIVFLPPSFPIVAMENPCLTFIISSILESDEFLIIDVIHEVAHSWFGNAVTNATWEEMWLSEGLATYAQRRITTETYGAAFTCLETAFRLDALHRQMKLLGEDNPVSKLQVKLEPGVNPSNLMNLFTYEKGYCFVYYLSQLCGDPGRFDSFLRAYIEKYKFTSVVAQDLLDSFLNFFPDLKEQCVESKAGLEFERWLNATGPPLAEPDLSQGSSLTRPVETLFKLWTTEPLDSDAAASSADLTKWRTFQTVLFLDRLLDGSPLRHEVIKKLSECYSSQLDSMNAEIRIRWLQIVVRNDYYPDLYKVRRFLENQMSRMYTIPLYEDLCTGTLKSFALEIFYQTQNQLHPNLRKTIQQILSQGLNPLPAIDTTAGAADTPAMVLEDKVSEATNGAISLRDVNVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TRC7</accession>
    <name>A0A8C2TRC7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Parvalbumin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC107320546</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the parvalbumin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TRC7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005023229.1">
        <property type="protein sequence ID" value="ENSCJPP00005016544.1"/>
        <property type="gene ID" value="ENSCJPG00005013576.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000165760"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16251">
        <property type="entry name" value="EFh_parvalbumin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000060">
        <property type="entry name" value="Parvalbumin, thymic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008080">
        <property type="entry name" value="Parvalbumin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11653">
        <property type="entry name" value="PARVALBUMIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11653:SF3">
        <property type="entry name" value="PARVALBUMIN, THYMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01697">
        <property type="entry name" value="PARVALBUMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0106">Calcium</keyword>
    <keyword evidence="2 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="39"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR608080-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005016544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="118" mass="12652" checksum="401128F27DF0A83C" modified="2022-01-19" version="1">MAITDILSAKDIESALSSCQAEDSFNYKSFFSTVGLSSKTPDQIKKVFGILDQDKSGFIEEEELQLFLKNFSSSARVLTSAETKAFLAAGDTDGDGKIGVEGKAAGNFIQVRLQNACV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TRJ9</accession>
    <name>A0A8C2TRJ9_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Golgi SNAP receptor complex member 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">GOSR1</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of several multiprotein Golgi SNARE complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the GOSR1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015736379.1">
        <property type="nucleotide sequence ID" value="XM_015880893.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TRJ9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005022650.1">
        <property type="protein sequence ID" value="ENSCJPP00005016059.1"/>
        <property type="gene ID" value="ENSCJPG00005013189.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107322646"/>
    <dbReference type="KEGG" id="cjo:107322646"/>
    <dbReference type="CTD" id="9527"/>
    <dbReference type="GeneTree" id="ENSGT00390000008688"/>
    <dbReference type="OrthoDB" id="422156at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005797">
        <property type="term" value="C:Golgi medial cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048219">
        <property type="term" value="P:inter-Golgi cisterna vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15864">
        <property type="entry name" value="SNARE_GS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023601">
        <property type="entry name" value="Golgi_SNAP_su1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21094:SF2">
        <property type="entry name" value="GOLGI SNAP RECEPTOR COMPLEX MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21094">
        <property type="entry name" value="GOS-28 SNARE- RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027109">
        <property type="entry name" value="Golgi_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR027109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005016059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="245" mass="28048" checksum="B0C8D806F1FF5923" modified="2022-01-19" version="1">MAAGSSNYWEDLRKQARQLENELDLKLVSFSKLCTSSRDGRRDRYSSDTTPLLNGSSQDRMFETMAVEIEQLLGKLTGINDKMAEYTNSAGVPSLNAALMHTLQRHRDILQDYTHEFHKTKANFLAIRERENLLGSVRKDIESYKSGSGVNNRRTELFLKEHEHLRNSDRLIEETISIAMATKENMTSQRGMLKSIHSKMNTLANRFPAVNSLIQRINLRKRRDSFILGSIIGICTILLLLFAFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TT34</accession>
    <name>A0A8C2TT34_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protein S100-A4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Metastasin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">S100 calcium-binding protein A4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">S100A4</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Calcium-binding protein that plays a role in various cellular processes including motility, angiogenesis, cell differentiation, apoptosis, and autophagy. Increases cell motility and invasiveness by interacting with non-muscle myosin heavy chain (NMMHC) IIA/MYH9. Mechanistically, promotes filament depolymerization and increases the amount of soluble myosin-IIA, resulting in the formation of stable protrusions facilitating chemotaxis. Also modulates the pro-apoptotic function of TP53 by binding to its C-terminal transactivation domain within the nucleus and reducing its protein levels. Within the extracellular space, stimulates cytokine production including granulocyte colony-stimulating factor and CCL24 from T-lymphocytes. In addition, stimulates T-lymphocyte chemotaxis by acting as a chemoattractant complex with PGLYRP1 that promotes lymphocyte migration via CCR5 and CXCR3 receptors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the S-100 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TT34"/>
    <dbReference type="Ensembl" id="ENSCJPT00005024081.1">
        <property type="protein sequence ID" value="ENSCJPP00005017252.1"/>
        <property type="gene ID" value="ENSCJPG00005014116.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161276"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048306">
        <property type="term" value="F:calcium-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00213">
        <property type="entry name" value="S-100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000044">
        <property type="entry name" value="Protein S100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034325">
        <property type="entry name" value="S-100_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001751">
        <property type="entry name" value="S100/CaBP7/8-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013787">
        <property type="entry name" value="S100_Ca-bd_sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11639:SF51">
        <property type="entry name" value="PROTEIN S100-A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11639">
        <property type="entry name" value="S100 CALCIUM-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01023">
        <property type="entry name" value="S_100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01394">
        <property type="entry name" value="S_100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00303">
        <property type="entry name" value="S100_CABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="44"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00056127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005017252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="95" mass="10925" checksum="ED191B8BDF820982" modified="2022-01-19" version="1">MACPLEQALSVMVSTFHKYSGKEGDKFKLSKAELKELLTKELPSFITGFQKLMSNLDSNRDSEVDFHEYATFLACVAVMCNDFFQEYPDKMPRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TU51</accession>
    <name>A0A8C2TU51_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">PDE6D</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Promotes the release of prenylated target proteins from cellular membranes. Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location. Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E. Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide dissociation rate.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Interacts with the prenylated catalytic subunits of PDE6, an oligomer composed of two catalytic chains and two inhibitory chains; has no effect on enzyme activity but promotes the release of the prenylated enzyme from cell membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasmic vesicle membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the PDE6D/unc-119 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TU51"/>
    <dbReference type="Ensembl" id="ENSCJPT00005023434.1">
        <property type="protein sequence ID" value="ENSCJPP00005016716.1"/>
        <property type="gene ID" value="ENSCJPG00005013717.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000000263"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005095">
        <property type="term" value="F:GTPase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.50.40:FF:000002">
        <property type="entry name" value="Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.40">
        <property type="entry name" value="GMP phosphodiesterase, delta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008015">
        <property type="entry name" value="PDED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037036">
        <property type="entry name" value="PDED_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017287">
        <property type="entry name" value="Rhodop-sen_GMP-Pdiesterase_dsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12976">
        <property type="entry name" value="RETINAL ROD RHODOPSIN-SENSITIVE CGMP 3',5'-CYCLIC PHOSPHODIESTERASE DELTA-SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12976:SF0">
        <property type="entry name" value="RETINAL ROD RHODOPSIN-SENSITIVE CGMP 3',5'-CYCLIC PHOSPHODIESTERASE SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05351">
        <property type="entry name" value="GMP_PDE_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037825">
        <property type="entry name" value="GMP-Pdiesterase_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0140">cGMP</keyword>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="5" id="KW-0844">Vision</keyword>
    <feature type="domain" description="GMP phosphodiesterase delta subunit" evidence="6">
        <location>
            <begin position="12"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00074030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR037825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005016716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="145" mass="16813" checksum="46F1AF48154EAFEB" modified="2022-01-19" version="1">MSVTDRKGKEFLNWMNLRDAETGKILWQGTEDLSVPGVEHEARVPKKILKCKAVSRELNFSSAEQMEKFRLEQKVYFKGQCLEEWFFEFGFVIPNSTNTWQSLIEAAPESQMMSANVLTGNVIIETKFYDDDLLVSTSRVRLFYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TXF9</accession>
    <name>A0A8C2TXF9_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">TAF12</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF12 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015739035.1">
        <property type="nucleotide sequence ID" value="XM_015883549.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015739036.1">
        <property type="nucleotide sequence ID" value="XM_015883550.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TXF9"/>
    <dbReference type="SMR" id="A0A8C2TXF9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005027826.1">
        <property type="protein sequence ID" value="ENSCJPP00005020157.1"/>
        <property type="gene ID" value="ENSCJPG00005016269.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107323957"/>
    <dbReference type="CTD" id="6883"/>
    <dbReference type="GeneTree" id="ENSGT00390000002144"/>
    <dbReference type="OrthoDB" id="2193432at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033276">
        <property type="term" value="C:transcription factor TFTC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140297">
        <property type="term" value="F:DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042789">
        <property type="term" value="P:mRNA transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060261">
        <property type="term" value="P:positive regulation of transcription initiation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd07981">
        <property type="entry name" value="HFD_TAF12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000011">
        <property type="entry name" value="Transcription initiation factor TFIID subunit 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037794">
        <property type="entry name" value="TAF12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003228">
        <property type="entry name" value="TFIID_TAF12_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12264">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12264:SF21">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03847">
        <property type="entry name" value="TFIID_20kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 12" evidence="8">
        <location>
            <begin position="59"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005020157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="161" mass="17991" checksum="43200A97F26DCE22" modified="2022-01-19" version="1">MNQFGPSTLINLSNFSSIKPEPASTPPQSSMANSTAVAKMPGTPSGGGRLSPESNQVLTKKKLQDLVREVDPNEQLDEDVEEMLLQIADDFIESVVTAACQLARHRKSNTLEVKDVQLHLERQWNMWIPGFGSEEIRPYKKACTTEAHKQRMALIRKTTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TXN1</accession>
    <name>A0A8C2TXN1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Macoilin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Transmembrane protein 57</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">MACO1</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in the regulation of neuronal activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Rough endoplasmic reticulum membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the macoilin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015738847.1">
        <property type="nucleotide sequence ID" value="XM_015883361.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TXN1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005027897.1">
        <property type="protein sequence ID" value="ENSCJPP00005020228.1"/>
        <property type="gene ID" value="ENSCJPG00005016299.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107323892"/>
    <dbReference type="KEGG" id="cjo:107323892"/>
    <dbReference type="CTD" id="55219"/>
    <dbReference type="GeneTree" id="ENSGT00390000016613"/>
    <dbReference type="OrthoDB" id="10071111at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044306">
        <property type="term" value="C:neuron projection terminus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030867">
        <property type="term" value="C:rough endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023041">
        <property type="term" value="P:neuronal signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019130">
        <property type="entry name" value="Macoilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47464">
        <property type="entry name" value="MACOILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47464:SF2">
        <property type="entry name" value="MACOILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09726">
        <property type="entry name" value="Macoilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="74"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="321"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="633"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="381"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="591"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="321"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005020228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="662" mass="76155" checksum="24B43B41B31BAE13" modified="2022-01-19" version="1">MKRRSAECSKLRRPLRRNRIAEGIYGSTFLYLKFLVVWALVLLADFVLEFRFEYLWPFWLFIRSVYDSFRYQGLAFSVFFVCVAFTSNIICLLFIPIQWLFFAASTYVWVQYVWHTERGVCLPTVSLWILFVYIEAAIRFKDLKNFHVDLCRPFAAHCIGYPVVSLGFGFKSYVSYKMRLRKQKEVQKENEFYMQLLQQALPPEQQMLQRQEREAEEAKGLSEMDSSMLLQHNGGIPANKKLSATLPELEYREKGKEKDKDAKKHNLGINNNILQPVDSKIQEIEYMENHINSKRLNNDLVGSTENLLKEDSCTASSKNYKNVSGVVNSSPRSHSATNGSIPSASTKNEKKQKCPSKSPSAHKDLMENCIPNNQLSKPDALVRLEQDIKKLKADLQASRQIEQELRSQISSLSNTERGIRSEIGQLRQENELLQNKLHNAVQMKQKDKQMISQLEKKLKAEQEARAFVEKQLMEEKKRKKLEEATAARAVAFAAATRGECTETLRNRIRELETECKKLTIDIKLKEDQIRELEMKVQELRKYKENEKDTEVLMSALSAMQDKTQHLENSLSAETRIKLDLFSALGDAKRQLEIAQGQIIQKDQEIKELKQKIAEVMAVMPSITYTAATSTLSPVSPHYSSKFVETSPSGLDPNASVYQPMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TXW3</accession>
    <name>A0A8C2TXW3_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">TSPAN6</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">May be involved in cell proliferation and cell motility.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the tetraspanin (TM4SF) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015715864.1">
        <property type="nucleotide sequence ID" value="XM_015860378.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TXW3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005028045.1">
        <property type="protein sequence ID" value="ENSCJPP00005020336.1"/>
        <property type="gene ID" value="ENSCJPG00005016398.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107312718"/>
    <dbReference type="KEGG" id="cjo:107312718"/>
    <dbReference type="CTD" id="7105"/>
    <dbReference type="GeneTree" id="ENSGT00940000159092"/>
    <dbReference type="OrthoDB" id="9972904at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043124">
        <property type="term" value="P:negative regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0039532">
        <property type="term" value="P:negative regulation of cytoplasmic pattern recognition receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd03161">
        <property type="entry name" value="TM4SF2_6_like_LEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1450.10:FF:000003">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000301">
        <property type="entry name" value="Tetraspanin_animals"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018503">
        <property type="entry name" value="Tetraspanin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048232">
        <property type="entry name" value="TSN6/7_LEL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF169">
        <property type="entry name" value="TETRASPANIN-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002419">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00421">
        <property type="entry name" value="TM4_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="218"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="153"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00056010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR002419-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005020336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="252" mass="27705" checksum="34A7ECC49F68D1E0" modified="2022-01-19" version="1">MASPSRRLQTKPVITCLKSVLLTYTFVFWVSGIVLLAVGVWGTVSLAVYFSLLDEKATNVPFVLVGAGVVVVLLGTFGCFATCRGSPWMLKLYAMLLSLIFLIVLVAAVVGFVFRHEIKTSFESNLNLALKNYNGTADRHSEAVDTIQKTLHCCGVQNYSDWEKTEYFTQKGIPQSCCKSQDGCSVEDLRDPSKAKQKVFVDGCFFLVTSTMESKMSVVAGISFGIACFQLVGIILACCLSQYITNNQYEMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TY86</accession>
    <name>A0A8C2TY86_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ABC-type glutathione-S-conjugate transporter</fullName>
            <ecNumber evidence="11">7.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">ABCC6</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>leukotriene C4(in) + ATP + H2O = leukotriene C4(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38963"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57973"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:38964"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.3" evidence="11"/>
    <dbReference type="Ensembl" id="ENSCJPT00005026000.1">
        <property type="protein sequence ID" value="ENSCJPP00005018735.1"/>
        <property type="gene ID" value="ENSCJPG00005015234.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157145"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015431">
        <property type="term" value="F:ABC-type glutathione S-conjugate transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015867">
        <property type="term" value="P:ATP transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055074">
        <property type="term" value="P:calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071716">
        <property type="term" value="P:leukotriene transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055062">
        <property type="term" value="P:phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd18595">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18603">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000293">
        <property type="entry name" value="ATP binding cassette subfamily C member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000032">
        <property type="entry name" value="ATP-binding cassette sub-family C member 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000001">
        <property type="entry name" value="ATP-binding cassette subfamily C member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001147">
        <property type="entry name" value="multidrug resistance-associated protein 6 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF339">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="288"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="335"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="358"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="409"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="437"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="516"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="555"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="928"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1115"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="15">
        <location>
            <begin position="298"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="609"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="15">
        <location>
            <begin position="890"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="1205"/>
            <end position="1437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005018735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1441" mass="161469" checksum="12CF3E218EFDE483" modified="2022-01-19" version="1">MKPWTHIAAAPGSHRPKRRPEIPGRSPSCPGCTSASCPRGHCLPFTLRQLPAGLCSPSRVLAWIPCAYLWICFPFYYSYLRHKNKGYIRMSHIFKIKMVLGFLLVILCFSNVFFVMWEISQGIPRTPAFFISPAVLGITMVILLLSHLCVAQLSPLWALLVFPMFLILPPSHLVLGELVLFCLVDHPPFFSKANQCPEASSSFLSKITYWWFSGLVWKGCRQSLGVDDLWSVRKKDSSEEIVAWAEKEWKKYNKRMKHQKTETDTAEAEETEVLLQSEHSQSGPLLQAFWSMFGTYFLLSTLCLVICDVFLFSIPKILSLFLEFIEDQEAPSWHGYFYAFVLVLLACLQTLFEQRYMYMCLVLGLRLKTAVTGLVYRKILIMSSASRKTVTVGEIVNLVSVDVQKLMDLIIYFNGTWLAPIRIIICFVFLWQLLGPSALASIAVFLFLLPLNFMITKRRSHFQEAQMKHKDERAKLTNAILSDIKVIKLYGWEKTFMEKVHAIRRQELQALKRSQILFSASLASFHSSTFLIAFVMFAVYTLVDNTHVLDAQKAFVSLTLINILNTAHSFLPFSINAAVQVNCRLRFFFFGLMSFLYIPPLKVPASIIIRNGTFCWSKDTSPCLRRIDLTVPQGSLLAVVGQVGAGKSSLLSALLGDLEKMDGFVTMKGTAAYVPQQAWIQNASVEDNILFGKKMDETWFNRVVDACALQPDLESFPAGQKSEIGEKGINISGGQKQRVSLARAVYQRSSIYLLDDPLSAVDAHVGQHIFEHVLGPNGLLKDKTRVLVTHMISVLHQVDNIVVLVNGMIAEIGSYQELSQRNGAFAEFLQSHNTAEEKACSGFPGNASCTTAEVTEGRLTRGEKTQRGRVNTSVYAAYLRAAGLPLCAYIILLFTCQQVLSFFRGYWLSVWTEDPVHNGTQQYTELRVGVFGALGVIQGLFVSTAAVFLGGMSASHKLFLQLLRNVARSPTVFFEETPIGNLLNRFSKEMDAIDSIIPDKLKSLLGFLFNLLEIYLVIIVATPKAAIAIVPLTAFYAVFQHFYVTTSCQLRRLEAASRSPIYSHISETFHGSSVIRAYKDQERFITKSNSLVDENLRICFPGAVADRWLATNLEFLGNGVVLFAALFAAIGRTHLSPGTAGFSISYALQITGVLNWMVRSWTEIENNIVSVERVSEYSRTPKEAPWTLNNKLQGQVWLTEGRIEFRNYSLRYRPNLELALKHINLTINGKEKIGITGRTGAGKSTLAAGLLRLVEAAEGAILIDGQDIAQLGLHDLRMKITVIPQDPVLFSGTLRMNLDPLNQYTDADIWTALELTQLKNFVADLPEQLEYKCTDQGENLSTGQKQLVCLARALLQKAKVLILDEATAAIDTETDLQIQSALRTQFKESTVLTIAHRINTIMDCDRILVLENGQIAEFDTPKQLIAQKGLFYKLMEESGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TZ74</accession>
    <name>A0A8C2TZ74_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">polyribonucleotide nucleotidyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">PNPT1</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polyribonucleotide nucleotidyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.8" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2TZ74"/>
    <dbReference type="Ensembl" id="ENSCJPT00005028803.1">
        <property type="protein sequence ID" value="ENSCJPP00005020937.1"/>
        <property type="gene ID" value="ENSCJPG00005016570.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000014001"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045025">
        <property type="term" value="C:mitochondrial degradosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035198">
        <property type="term" value="F:miRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034046">
        <property type="term" value="F:poly(G) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008266">
        <property type="term" value="F:poly(U) RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004654">
        <property type="term" value="F:polyribonucleotide nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035458">
        <property type="term" value="P:cellular response to interferon-beta"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000958">
        <property type="term" value="P:mitochondrial mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097222">
        <property type="term" value="P:mitochondrial mRNA polyadenylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000965">
        <property type="term" value="P:mitochondrial RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000964">
        <property type="term" value="P:mitochondrial RNA 5'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071042">
        <property type="term" value="P:nuclear polyadenylation-dependent mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000627">
        <property type="term" value="P:positive regulation of miRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000962">
        <property type="term" value="P:positive regulation of mitochondrial RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070207">
        <property type="term" value="P:protein homotrimerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043457">
        <property type="term" value="P:regulation of cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000772">
        <property type="term" value="P:regulation of cellular senescence"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035928">
        <property type="term" value="P:rRNA import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd09033">
        <property type="entry name" value="KH-I_PNPT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11364">
        <property type="entry name" value="RNase_PH_PNPase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000113">
        <property type="entry name" value="polyribonucleotide nucleotidyltransferase 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000044">
        <property type="entry name" value="Polyribonucleotide nucleotidyltransferase 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.70:FF:000006">
        <property type="entry name" value="polyribonucleotide nucleotidyltransferase 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.70:FF:000008">
        <property type="entry name" value="polyribonucleotide nucleotidyltransferase 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012162">
        <property type="entry name" value="PNPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015848">
        <property type="entry name" value="PNPase_PH_RNA-bd_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03591">
        <property type="entry name" value="polynuc_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008805">
        <property type="entry name" value="PRK11824.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11252">
        <property type="entry name" value="POLYRIBONUCLEOTIDE NUCLEOTIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11252:SF0">
        <property type="entry name" value="POLYRIBONUCLEOTIDE NUCLEOTIDYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03726">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005499">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S1 motif" evidence="7">
        <location>
            <begin position="595"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005020937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="698" mass="77116" checksum="58EE7FF28E93053A" modified="2022-01-19" version="1">QASWLMPPSLRCSRPQLDGPRRGWNYISLMSLPTGSFVDYRQKAAAAGRIPTNYLRRELGTTDKEILTSRVIDRSIRPLFPVGYFYDTQILCNLLAVDGVNDPDILAINGASAALALSDIPWNGPVGAVRVGLVDGETVINPTRKQMSSSTLNLVVAAAPQNQVVMLEATAENILQQDFCHAIKVGVKQTQHIIQGIQQLVKERGVVKRTVQKLFVAPEEIVESISRDEAINKIRLETEEQLKEKFPEAEPYEIMESFNAVSKDIFRNLILNEYRRCDGRDLTSLRDIKCEVNMFKMLHGSALFQRGQTQVLCTVTFDSIESSVKSDLISTAVRYVYLWMFFLSFPPYATNEIGKVTGVNRRELGHGALAERALKPIIPQDFPFTIRVTSEVLESNGSSSMASACGGSLALMDAGVPVSSAVAGVAVGLVTKYDLEGKDLEDYRLLTDILGIEDYYGDMDFKLAGTSKGVTALQVDLKLPGIPIKIIMEAIQQATAAKREILQIMNETLAKPRPNRKESGPVVETIHVPLSKRLRFLGPGAYNLKKLQAKTGVTLSQLDEETYSMFAPTPSAMHEAREFIGELCKDDQEINLEFGAVYTATITEIRDSGVMVKLYPNMTPVLLHNSQLDQRKIKHPSALGLEVGQEIQVKYFGRDPTDGRMRLSRKVLQSPATTVLKTLTDKNSIVLGSTAPESSTSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U1C5</accession>
    <name>A0A8C2U1C5_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Nucleoredoxin</fullName>
            <ecNumber evidence="3">1.8.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">NXN</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>[protein]-dithiol + NAD(+) = [protein]-disulfide + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18749"/>
            <dbReference type="Rhea" id="RHEA-COMP:10593"/>
            <dbReference type="Rhea" id="RHEA-COMP:10594"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.8.1.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[protein]-dithiol + NADP(+) = [protein]-disulfide + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18753"/>
            <dbReference type="Rhea" id="RHEA-COMP:10593"/>
            <dbReference type="Rhea" id="RHEA-COMP:10594"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the nucleoredoxin family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.8" evidence="3"/>
    <dbReference type="RefSeq" id="XP_015736250.1">
        <property type="nucleotide sequence ID" value="XM_015880764.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U1C5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005028253.1">
        <property type="protein sequence ID" value="ENSCJPP00005020476.1"/>
        <property type="gene ID" value="ENSCJPG00005016491.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107322586"/>
    <dbReference type="KEGG" id="cjo:107322586"/>
    <dbReference type="CTD" id="64359"/>
    <dbReference type="GeneTree" id="ENSGT00940000161894"/>
    <dbReference type="OrthoDB" id="9440957at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072359">
        <property type="term" value="P:circulatory system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031397">
        <property type="term" value="P:negative regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030178">
        <property type="term" value="P:negative regulation of Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03071">
        <property type="entry name" value="PDI_b'_NRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03009">
        <property type="entry name" value="TryX_like_TryX_NRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000062">
        <property type="entry name" value="Nucleoredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000064">
        <property type="entry name" value="Nucleoredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000210">
        <property type="entry name" value="nucleoredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041861">
        <property type="entry name" value="NRX_PDI_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045870">
        <property type="entry name" value="TryX_NRX_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46472">
        <property type="entry name" value="NUCLEOREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46472:SF1">
        <property type="entry name" value="NUCLEOREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13905">
        <property type="entry name" value="Thioredoxin_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-0221">Differentiation</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="domain" description="Thioredoxin" evidence="15">
        <location>
            <begin position="150"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00026178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005020476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="421" mass="46650" checksum="5383A56E26E5CF4E" modified="2022-01-19" version="1">MAGALSEVLGEVLVSADGEEVSVSALSARGVSLVGLYFGCSLSGPCAQLGASLAAFYGRFRGEAAAAGAQRLEIVFVSAEQEQQQWQDAVRTMPWLALPFNEKHRKLKLWNKYRVSNIPSLIFIDASTGKVVCRNGLLVIRDDPEGLEFPWGPKPFSEVVAGPLLRNNGQTLDSSALEGSHVGVYFSAHWCPPCRSLTRVLVESYRKIKEAGQKFEILFVSADRSEDSFKQYFSEMPWVAVPYTDEARRSRLNRLYGIQGIPTLIVLDSQGEVITRQGRVEVLNDIECREFPWHPKPVLELTDSNAVQLNEGPCLVLFVDSEDDGESEAAKQLIQPIAEKIIAKYKAKEEEAPLLFFVAGEDDMTDSLRDYTNLPEAAPLLTILDMSARAKYVMDVEEITPEIVEAFVSDFLADKLKPEPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U5Q3</accession>
    <name>A0A8C2U5Q3_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">TM9SF3</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2U5Q3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005031587.1">
        <property type="protein sequence ID" value="ENSCJPP00005023059.1"/>
        <property type="gene ID" value="ENSCJPG00005018311.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155493"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004240">
        <property type="entry name" value="EMP70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766:SF41">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034249129" description="Transmembrane 9 superfamily member" evidence="7">
        <location>
            <begin position="27"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="287"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="358"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="445"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="479"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="517"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="549"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005023059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="587" mass="67782" checksum="DA3B6E88D5F7A533" modified="2022-01-19" version="1">MAAPGLWLLRAAAALLLLCRPPRARADEHEHTYQDKEEVVLWMNTVGPYHNRQETYKYFSLPFCVGSKKSISHYHETLGEALQGVELEFSGLDIKFKDDVMQTTYCEIDLDKGRREAFVYAIKNHYWYQMYIDDLPIWGIVGEADENGEDYYLWTYKKLEIGYNANRIVDVNLTSEGKVKLVPNTKIQMSYSVKWKKSDVKFEDRFDKYLDPSFFQHRIHWFSIFNSFMMVIFLVGLVSMILMRTLRKDYARYSKEEEMDDMDRDLGDEYGWKQVHGDVFRPSSHPLIFSSLIGSGCQIFAVSLIVIVVAMIEDLYTERGSMLSTAIFVYAATSPVNGYFGGSLYARQGGRRWIKQMFIGAFLIPAMVCGTAFFINFIAIYYHASRAIPFGTMVAVCCICFFVILPLNLVGTILGRNLSGQPNFPCRVNAVPRPIPEKKWFMEPAVIVCLGGILPFGSIFIEMYFIFTSFWAYKIYYVYGFMMLVLVILCIVTVCVTIVCTYFLLNAEDYRWQWTSFLSAASTAIYVYMYSFYYYFFKTKMYGLFQTSFYFGYMAVFSTALGIMCGAIGYMGTSAFVRKIYTNVKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U5V1</accession>
    <name>A0A8C2U5V1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Homeobox protein Hox-D8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">HOXD8</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Antp homeobox family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015723948.1">
        <property type="nucleotide sequence ID" value="XM_015868462.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U5V1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005030463.1">
        <property type="protein sequence ID" value="ENSCJPP00005022196.1"/>
        <property type="gene ID" value="ENSCJPG00005017729.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107316679"/>
    <dbReference type="KEGG" id="cjo:107316679"/>
    <dbReference type="CTD" id="3234"/>
    <dbReference type="GeneTree" id="ENSGT00940000161653"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009952">
        <property type="term" value="P:anterior/posterior pattern specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048705">
        <property type="term" value="P:skeletal system morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000072">
        <property type="entry name" value="Homeobox protein Hox-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050948">
        <property type="entry name" value="Antp_homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001827">
        <property type="entry name" value="Homeobox_Antennapedia_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000047">
        <property type="entry name" value="HTH_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46166">
        <property type="entry name" value="HOMEOBOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46166:SF1">
        <property type="entry name" value="HOMEOBOX PROTEIN HOX-D8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00031">
        <property type="entry name" value="HTHREPRESSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00032">
        <property type="entry name" value="ANTENNAPEDIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6 11 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 11 12" id="KW-0371">Homeobox</keyword>
    <keyword evidence="9 11 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="14">
        <location>
            <begin position="172"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="11">
        <location>
            <begin position="174"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="66"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="231"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="72"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="86"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="231"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005022196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="267" mass="29295" checksum="455E233487AA353A" modified="2022-01-19" version="1">MSSYFVNPLYSKYKAAAAAAAAVAAGEPLPAPYYDCHFAPEVSGRHAAAAAALLYGTGFPQPGGAGGGGGADFYHPAGGSPAAAYQPPPPPPAAPPPPAPCSGVTCHGEPAKFYGYDNLQRQQIFTTQQEAELVQYPDCKSSSANIGEEPDHLNQSSSPAQMFPWMRPQAAPGRRRGRQTYSRFQTLELEKEFLFNPYLTRKRRIEVSHALGLTERQVKIWFQNRRMKWKKENNKDKFPASKQEGKEGEAKKETHDLEDDRAESHTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U5V6</accession>
    <name>A0A8C2U5V6_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Chromatin remodeling regulator CECR2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">CECR2</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="Ensembl" id="ENSCJPT00005032446.1">
        <property type="protein sequence ID" value="ENSCJPP00005023718.1"/>
        <property type="gene ID" value="ENSCJPG00005018763.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160360"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090537">
        <property type="term" value="C:CERF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000791">
        <property type="term" value="C:euchromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090102">
        <property type="term" value="P:cochlea development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097194">
        <property type="term" value="P:execution phase of apoptosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060122">
        <property type="term" value="P:inner ear receptor cell stereocilium organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001842">
        <property type="term" value="P:neural fold formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001843">
        <property type="term" value="P:neural tube closure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007338">
        <property type="term" value="P:single fertilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd05509">
        <property type="entry name" value="Bromo_gcn5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000027">
        <property type="entry name" value="Cat eye syndrome critical region protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029614">
        <property type="entry name" value="CECR2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47092">
        <property type="entry name" value="CAT EYE SYNDROME CRITICAL REGION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47092:SF1">
        <property type="entry name" value="CHROMATIN REMODELING REGULATOR CECR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="10">
        <location>
            <begin position="451"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="557"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="792"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="916"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="993"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1210"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1411"/>
            <end position="1479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="600"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="916"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="949"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1272"/>
            <end position="1296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00068581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005023718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1479" mass="162392" checksum="D6E3B6F123E3857A" modified="2022-01-19" version="1">MCPEEDGGCGGGGGGGGGGGGVAGTGGTEAAAAAALDELRSWWEVPAIAHFCSLFRTAFRLPDFEIEELEAALHRDDVEFISDLIACLLQGCYQRRDITSQTFHSYLEDIINYRWELEEGKPNPLRESTFQELPLRTRVEILHRLCDYRLDADDVFDLLKGLDADSLRVEPLGEDSSGALYWYFYGTRMYKEDPVQAKTNGELAPDRGCGGQTNTPNVPGKTAITAVEITSFHVVEGSQGPGRGTWWLLCQTEEEWRQVTESFRERTSLRERQLYKLLSEDFLPEICNMIAQKEKRLQRTEFSPRWMSDHQPIKPIKQEVNPNVLSSMEKQRRREEEEERQILIAVQKREQEQLLKEERKREMEEKVKAVEGMCNHAKWILCSSSLPAAERARRRKLREERAWLLAQGKELPPELSHLDPSSPTREERRTKDLFELDDEFTAMYKVLDVVKAHKDSWPFLEPVDESYAPNYYQIIKAPMDISSMEKKLNGGQYCTKEEFVGDMKTMFRNCLKYNGEGSEYTKMAYNLERCFHRAMMKHFPGEDGDTDDEFWIREDGRREKRSRRTGRSSGGNVWTRSRDSEGPGKRQQRLENGGKPPPYRATSRAPASSSSSSGNSMQPPREVGPSNGRGFPRSLQYGGMPNSVPHPGQMRPAIPGTFGSLRGSDPTKLYGSPRVPEPHPGDPVQQHQHFAMQPAVGLNEHRGHRLATPEKQVCAGPTHITGLGPRPSALQLGCMSGPPPDAVYSPAQFQQGFLPPRHNGPPVRPPEGSEMPPGHMYRPYKYLNRGHPALWNGSHGASSQSAVGAEEKAPMGPAPSLQPRTIGHMMEPRAIRPPLPPSQWTEQSNFLPHGVPPSGYIRPPGKNTSQRMPQPPAALFGGLPQVQKGCQGGDSMMDSPEMIAMQQLSSRVCPPGVPYHPRQPPPPHLPGPFPQLAHAASTGVPPPKPVMGNGSSQDQTMESESNQVEPLAGVEEKAQCIGIPDRAYAKLLPHPKPPLPMECARRNLPPDGEGDGSGLKSDLKANQSKGTWPAESSYAGPGAQGCMRDLASTPERGGPVSENGAVGEGTAESKGLAGSLMEKPLCSGGKALPEAAVPCMGQGTSLPAMDAGTVGAAPNQFHPLYMPGLEYPNSAARYHINPGLQGFSPVMGGKPPPVSHPQHFPARGFQPSNAHPGVFPRYRPHQGMPYPYQPQPQPSYHHYQRPPYYTCPQGYSDWQRPLHPQASPSGHPPLARPPFSERGNVSSLQGCEALSAALASPSRMDVASAKEVSPSDGRDLGPEDEKSEESQERPESPKEFLDLDNHNAATKRQSSVAAGEFLYGAPSPHLGSGMGFGPSAFPPHGVMLQTGSPYASRHPASHFQPRTYGSPMNAHLSHHPAPGQANGLSQEGPLYRCREENIGHFQALLMEQRGSGGGMGGPPQDLYRPSGMQMHQAPFPKMPPATMSREDLMPQKSSALPLDQVRASKESRAQMRAFSCSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U5X4</accession>
    <name>A0A8C2U5X4_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Protein transport protein Sec31A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">SEC31-like protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">SEC31-related protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">SEC31B</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">COPII-coated vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat SEC31 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015722220.1">
        <property type="nucleotide sequence ID" value="XM_015866734.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015722221.1">
        <property type="nucleotide sequence ID" value="XM_015866735.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015722222.1">
        <property type="nucleotide sequence ID" value="XM_015866736.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U5X4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005032598.1">
        <property type="protein sequence ID" value="ENSCJPP00005023856.1"/>
        <property type="gene ID" value="ENSCJPG00005018851.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107315862"/>
    <dbReference type="KEGG" id="cjo:107315862"/>
    <dbReference type="CTD" id="25956"/>
    <dbReference type="GeneTree" id="ENSGT00390000003175"/>
    <dbReference type="OrthoDB" id="542917at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007029">
        <property type="term" value="P:endoplasmic reticulum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.940.10:FF:000001">
        <property type="entry name" value="Protein transport protein Sec31A isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000009">
        <property type="entry name" value="Protein transport protein Sec31A isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1030:FF:000006">
        <property type="entry name" value="SEC31 homolog B, COPII coat complex component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.940.10">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040251">
        <property type="entry name" value="SEC31-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13923:SF22">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC31B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13923">
        <property type="entry name" value="SEC31-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="6 17" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="17">
        <location>
            <begin position="117"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="17">
        <location>
            <begin position="255"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="508"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="812"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="825"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="840"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="874"/>
            <end position="886"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00043112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005023856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1240" mass="135088" checksum="5383D9651E02C675" modified="2022-01-19" version="1">MKLKEIERTAVEAWSPANNHPIYLATGTSAQQLDASFSTNATLEIFEVDFRDPSLDMKQKGTLPASNRFHKLIWGNFGNGSSESSGVIIGGGDNGVLTMYSAHRILTSKSDPVIGQTEKHSGPVRALDFNPFQSNLLASGANDSEIFIWDLNNFSVPMTPGTKSQPHEDISVVSWNRQVQHILSSAHPSGKAVVWDLRKNEPIIKVSDHSNRMHCSGMAWHPEVATQLVLSSEDDRLPVIQIWDLRFATSPLSQLEGHTRGVLSVSWCQADPDLLLSSAKDNRILCWNPSTGEVVYELPIRSQWCFDVQWCPRNPSVFSAATFDGWINIYSVMGGNLEAQQKTQADKISSSFNNLDPFGTGQTLPPLQVPEQVAQTTLIPPLKKPPKWIRRPVGVSFAFGGKLITFGFTKAPGQQIQQTYSHQVFISQVTTETEFLLRSKELQMALQSGNLLDYCESKIHTAKLKYEENLWKFLKVNLEQESRTKLLKLLGYSKEDLQKKITSCLSNGIPDKQPLPEADDTNTAHPDQLLMNSSDDVAALSSSSAFFDNLVPQNMSTLDIPVTEDTDGLISQALLLGNFEGAVELCMRAERFADAIILAIAGGENLLKETQKRYFAKQKTKLSLLLSSIVQQKWQDIVCTCDLQSWKEALAILLTYSKHEDYAQLCDMLGSRLELEGDAALSNDACLCYISSGNVERLVECWVKSHETSSPLALQDLIEKVMVLSRSIEMLRGTAETVPGPVLAEQITQYASLLASQGCLAAAMNYLPNNSKELLIEQLRDRLFHAQGENVGNQPPPPFPYARVNVGVMKHTSPAAQRGSTPEGAAHKTDHRHPEKPNYQPSFAPSAPSQPSVPSFFPPQPVPAMSAAPHHNVPPQTSTSPQTSVYSRGPPYPQYNMGMVPATASGPALSQSQPFSPVARPVGPAPFPSQPPLSGQSMPMASPGVLPSGPALLTPASIPSSQLPAACPLPVASQSPLGFTSAPFSSPMNLGYPQGGPGAPSAKPLPAASLPPPPIGFFPWLDPHVDHAGSTQRSFQTCRGGSVAACSETWAQDSWTDPSAARGGLQKKKLPEKFAPLAPITAPVMNLPTEPQGIHPQLSRLQESGQSPPGAPKEGSLQYHQLPAEKVEKKELPPEHQGLKTTLEGLVQRCSAVATDPKTRRKLEDALQRLETLYDKLREQALSPAILMGLHEIARCIEARNYQQGLMVHTQVVSSSSFSEVSGFMPVLKVLMTIAGKLNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U669</accession>
    <name>A0A8C2U669_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Protein HIRA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">HIRA</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the WD repeat HIR1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2U669"/>
    <dbReference type="Ensembl" id="ENSCJPT00005032929.1">
        <property type="protein sequence ID" value="ENSCJPP00005024131.1"/>
        <property type="gene ID" value="ENSCJPG00005019052.1"/>
    </dbReference>
    <dbReference type="KEGG" id="cjo:107321032"/>
    <dbReference type="GeneTree" id="ENSGT00550000074919"/>
    <dbReference type="OrthoDB" id="1741719at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000417">
        <property type="term" value="C:HIR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061629">
        <property type="term" value="F:RNA polymerase II-specific DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007369">
        <property type="term" value="P:gastrulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042692">
        <property type="term" value="P:muscle cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001649">
        <property type="term" value="P:osteoblast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000075">
        <property type="entry name" value="Protein HIRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000105">
        <property type="entry name" value="Protein HIRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055410">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031120">
        <property type="entry name" value="HIR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011494">
        <property type="entry name" value="HIRA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13831">
        <property type="entry name" value="MEMBER OF THE HIR1 FAMILY OF WD-REPEAT PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13831:SF0">
        <property type="entry name" value="PROTEIN HIRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24105">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07569">
        <property type="entry name" value="Hira"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0678">Repressor</keyword>
    <keyword evidence="9 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="8 12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 11 12" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CAF1B/HIR1 beta-propeller" evidence="15">
        <location>
            <begin position="1"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="66"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="127"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="170"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Protein HIRA-like C-terminal" evidence="14">
        <location>
            <begin position="770"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="405"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="513"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="601"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="405"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="544"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="601"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07569"/>
        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF24105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005024131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1023" mass="112588" checksum="548656D66E04DC97" modified="2022-01-19" version="1">MKLLKPTWVNHNGKPIFSVDIHPDGTKFATGGQGQDSGKVVIWNMAPVLKEEDEKNENIPKMLCQMDNHLACVNCVRWSNNGVYLASGGDDKLIMVWKRAAYIGPSTVFGSSSKLTNVEQWRCVSILRSHSGDVMDVAWSPHDAWLASCSVDNTVVIWNAVKFPEILATLKGHSGLVKGLTWDPVGKYIASQADDRSLKVWRTMDWQLETSITKPFDECGGTTHVLRLSWSPDGHYLVSAHAMNNSGPTAQIIERDGWKTNMDFVGHRKAVTVVKFNPKIFKKKQKNGSSTKSSCPYCCCAVGSKDRSLSVWLTCLKRPLVVIHELFDKSIMDISWTLNGLGILVCSMDGSVAFLDFSQDELGDPLSEEEKSNIHQSTYGKSLAIMTEAQLSTTIIENPEMLKYQQRQQQQQAEQKNSSIRETSGAAATAPKVASMVNGESLEDIRKNLLKKQVETRTADGRRRITPLCIAQLDTGDFSTAFFNSIPISGTLAGSIMSSQNNQQLMSLDSNAANSLNTSKPSAEPTAASIKPTDDAANKDSVNATSVSTAPPASSSSVLTTPSKIEPMKAFDSRFTERSKATSGTAVVTNTNQAVVDRLKDQNLIKDNKPKDILESSSDSEEKIPAAKPLSAPKRKLELEGETVEKKKKGRPRKDSRLVPVTLTVQSPAALASEKDAACISAPALALKLPTPIPQKSFTLQVSSDPSMYLEVENEMTMVGGSKLSRLKCNREGKEWETVLTSRILTAAGSCEIVCVACEKRTLSVFSACGRRLLPPIILNTPISTLHCTGSYIMTLTTAATLSVWDVHKQTVIVRDESLQTILSGSDTTVSQILLTQHGIPVMSMSDGKAYCFNPSLSTWNLVSDKQDSLAQCADFRSSLPSQEAMLCSGPLAVIQGRTSNSGRQAARLFSMPHLVQQETTLAYLENQIAAALMLQSSHEYRHWLLIYARYLVNEGFEYRLRELCKDLLGPVHYSAGSQWESTVMGLRKRELLKELLPVIGQNLRFQRLFTEYQEQLDILRDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U6K2</accession>
    <name>A0A8C2U6K2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NF-kappa-B inhibitor zeta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">I-kappa-B-zeta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Molecule possessing ankyrin repeats induced by lipopolysaccharide</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">NFKBIZ</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in regulation of NF-kappa-B transcription factor complexes. Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation. Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer. Also seems to activate NF-kappa-B-mediated transcription. In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters. Promotes transcription of LCN2 and DEFB4. Is recruited to IL-6 promoters and activates IL-6 but decreases TNF-alpha production in response to LPS. Seems to be involved in the induction of inflammatory genes activated through TLR/IL-1 receptor signaling. Involved in the induction of T helper 17 cells (Th17) differentiation upon recognition of antigen by T cell antigen receptor (TCR).</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with NFKB1/p50. Interacts with RELA. Interacts with AKIRIN2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015732910.1">
        <property type="nucleotide sequence ID" value="XM_015877424.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U6K2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005030229.1">
        <property type="protein sequence ID" value="ENSCJPP00005022050.1"/>
        <property type="gene ID" value="ENSCJPG00005017617.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107320972"/>
    <dbReference type="CTD" id="64332"/>
    <dbReference type="GeneTree" id="ENSGT00940000153695"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036464">
        <property type="term" value="C:cytoplasmic ribonucleoprotein granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070974">
        <property type="term" value="F:POU domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042100">
        <property type="term" value="P:B cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990117">
        <property type="term" value="P:B cell receptor apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097398">
        <property type="term" value="P:cellular response to interleukin-17"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071222">
        <property type="term" value="P:cellular response to lipopolysaccharide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071560">
        <property type="term" value="P:cellular response to transforming growth factor beta stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002544">
        <property type="term" value="P:chronic inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019221">
        <property type="term" value="P:cytokine-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050829">
        <property type="term" value="P:defense response to Gram-negative bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904019">
        <property type="term" value="P:epithelial cell apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061436">
        <property type="term" value="P:establishment of skin barrier"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097194">
        <property type="term" value="P:execution phase of apoptosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048873">
        <property type="term" value="P:homeostasis of number of cells within a tissue"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090594">
        <property type="term" value="P:inflammatory response to wounding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045190">
        <property type="term" value="P:isotype switching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032980">
        <property type="term" value="P:keratinocyte activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030216">
        <property type="term" value="P:keratinocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043616">
        <property type="term" value="P:keratinocyte proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042789">
        <property type="term" value="P:mRNA transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050729">
        <property type="term" value="P:positive regulation of inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000321">
        <property type="term" value="P:positive regulation of T-helper 17 cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072718">
        <property type="term" value="P:response to cisplatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051593">
        <property type="term" value="P:response to folic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140459">
        <property type="term" value="P:response to Gram-positive bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009410">
        <property type="term" value="P:response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048536">
        <property type="term" value="P:spleen development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002456">
        <property type="term" value="P:T cell mediated immunity"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
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        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="NF-KAPPA-B INHIBITOR ZETA"/>
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        <property type="entry name" value="Ank_2"/>
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        <property type="entry name" value="ANKYRIN"/>
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        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
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        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ANK_REPEAT"/>
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        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="4 13" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="OCA" evidence="15">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="13">
        <location>
            <begin position="458"/>
            <end position="490"/>
        </location>
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    <feature type="repeat" description="ANK" evidence="13">
        <location>
            <begin position="591"/>
            <end position="613"/>
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    <feature type="repeat" description="ANK" evidence="13">
        <location>
            <begin position="627"/>
            <end position="663"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="30"/>
            <end position="93"/>
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    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="162"/>
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        <location>
            <begin position="228"/>
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            <begin position="258"/>
            <end position="281"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="183"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="269"/>
            <end position="281"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="697" mass="75579" checksum="BE88913E539EF399" modified="2022-01-19" version="1">MIVDSSRDAAPDGDGGALSSPINLAYFYGASPHSSEGSCSPAHSAPGSPGSDSDLSVSSRGGGRRDGRGGARPALQAEQHMGGGKQHRGPFQGVRVKNSVKELLLHFRSSKQMSSGPAADENKAQGGLVNYEPYTELKSILGQGGKRKASELLSDGPPFKRQVNIHPHLLTPPQTPTSMDNVEETHKNEPKHDSSSDLLQNIINIKNESSPVSLNTVQVSWLHGVSSHNSPGEQYHDSPGTQAFSPPQKYQAFQDHTSQNMLDPPQHYQFPSSQSQDLSQNYTSDASLEYRPFSASDQSPGYHQHAYESHELQYCPSQSFSSLLNDSEGSENISAPLQSLTSAHPQANVSPHAQNFSLAPSNVCGGLERSVSLATLNVSLPPQSVARNTTQLGKSFFQWQVEQEENKLANISQDQFLAKDSDGDTFLHIAVAQGRRALSYVLARKMAALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVSLGAQVNTTDCWGRTPLHVCAEKGHAQVLQAIQKGAMGSNQYVDLEATNYDGLTALHCAVLAHNAVLHELQNCQPPHSPEVQELLLRNKSLVETIKTLIQMGASVEAKDRKSGRSALHLAAEEANLELIRLFLELPNCLSFVNAKAYNGNTALHVAASLQYRVSQLDAVRLLMRKGADPSARNLENEQPVHLVPDGLVGEQIRRILKGKTVQQRASLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U6L7</accession>
    <name>A0A8C2U6L7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">tRNA-t(6)A37 methylthiotransferase</fullName>
            <ecNumber evidence="15">2.8.4.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">CDKAL1</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 15">Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:37075"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="Rhea" id="RHEA-COMP:11092"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:74420"/>
            <dbReference type="EC" id="2.8.4.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="15">Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Endoplasmic reticulum membrane</location>
            <topology evidence="15">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the methylthiotransferase family. CDKAL1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.4.5" evidence="15"/>
    <dbReference type="RefSeq" id="XP_015710241.1">
        <property type="nucleotide sequence ID" value="XM_015854755.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015710243.1">
        <property type="nucleotide sequence ID" value="XM_015854757.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U6L7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005030875.1">
        <property type="protein sequence ID" value="ENSCJPP00005022543.1"/>
        <property type="gene ID" value="ENSCJPG00005017938.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005030876.1">
        <property type="protein sequence ID" value="ENSCJPP00005022544.1"/>
        <property type="gene ID" value="ENSCJPG00005017938.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107309723"/>
    <dbReference type="KEGG" id="cjo:107309723"/>
    <dbReference type="CTD" id="54901"/>
    <dbReference type="GeneTree" id="ENSGT00940000155952"/>
    <dbReference type="OrthoDB" id="1730074at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005791">
        <property type="term" value="C:rough endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035598">
        <property type="term" value="F:tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990145">
        <property type="term" value="P:maintenance of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12160:FF:000005">
        <property type="entry name" value="threonylcarbamoyladenosine tRNA methylthiotransferase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.30.20:FF:000002">
        <property type="entry name" value="threonylcarbamoyladenosine tRNA methylthiotransferase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="entry name" value="Methylthiotransferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="entry name" value="tm_1862 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006466">
        <property type="entry name" value="MiaB-like_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01578">
        <property type="entry name" value="MiaB-like-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00089">
        <property type="entry name" value="MiaB/RimO family radical SAM methylthiotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11918">
        <property type="entry name" value="RADICAL SAM PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11918:SF45">
        <property type="entry name" value="THREONYLCARBAMOYLADENOSINE TRNA METHYLTHIOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01082">
        <property type="entry name" value="B12-binding_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01061">
        <property type="entry name" value="methylthiotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 15" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 15" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8 15" id="KW-0819">tRNA processing</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="559"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="MTTase N-terminal" evidence="17">
        <location>
            <begin position="62"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="18">
        <location>
            <begin position="198"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="16">
        <location>
            <begin position="429"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00051661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU368081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005022544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="582" mass="65829" checksum="2FF96ABDCBEB3DA6" modified="2022-01-19" version="1">MPAACDSVLEDIEDIVSAQDLKPHDLRFVRKNVFPKVRKRSSQQRSQTDDDPPCDSVIPGIQKIWIRTWGCSHNNSDGEYMAGQLAAYGYKITDNSAEADLWLLNSCTVKNPAEDHFRNSIKKAQEANKKVVVAGCVPQAQPRQDYLKGLSIIGVQQIDRVVEVVEETIKGHSVRLLGQKKDNGKRLGGARLDLPKIRKNPLIEIISINTGCLNACTYCKTKHARGDLASYPIEELVDRAKQSFQEGVCEIWLTSEDTGAYGRDIGTDLPTLLWKLVEAIPEGAMLRLGMTNPPYILEHLEEMAKILNHPRVYAFLHIPVQSASDSVLMDMRREYCVADFRRVVDFLKEKVPGITIATDIICGFPGETDEDFQETMKLVEQYKFPSLFINQFYPRPGTPAAKMHQVPAAVKKQRTKDLSRLFHSYNPYDHKVGERQRVLVTEESFDSNYYVAHNPFYEQVLVPKDPVLMGKMVEVNIYEAGKHFMKGQPVSDARVYTASITRPLAKGEVSGLTEEFRHVPQNGTKWKAHQSAEIPVKAPLIPWMTLHLPWHQEGSRLKILSVSLALLAFFAMFYYGGMKREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U715</accession>
    <name>A0A8C2U715_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Intestine-specific homeobox</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ISX</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Transcription factor that regulates gene expression in intestine. May participate in vitamin A metabolism most likely by regulating BCO1 expression in the intestine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015719032.1">
        <property type="nucleotide sequence ID" value="XM_015863546.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U715"/>
    <dbReference type="Ensembl" id="ENSCJPT00005031351.1">
        <property type="protein sequence ID" value="ENSCJPP00005022877.1"/>
        <property type="gene ID" value="ENSCJPG00005018181.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107314383"/>
    <dbReference type="KEGG" id="cjo:107314383"/>
    <dbReference type="CTD" id="91464"/>
    <dbReference type="GeneTree" id="ENSGT00940000161702"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000369">
        <property type="entry name" value="Intestine specific homeobox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050649">
        <property type="entry name" value="Paired_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329">
        <property type="entry name" value="HOMEOBOX PROTEIN ARISTALESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329:SF362">
        <property type="entry name" value="INTESTINE-SPECIFIC HOMEOBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="3 10 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 10 11" id="KW-0371">Homeobox</keyword>
    <keyword evidence="7 10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="13">
        <location>
            <begin position="141"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="10">
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            <begin position="143"/>
            <end position="202"/>
        </location>
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            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
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            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00055445"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00067428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005022877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="305" mass="34694" checksum="3B5BC2E394C07436" modified="2022-01-19" version="1">MMDPCECASQMKPGLSFSIEEILKKPSASTTSNETRNRNNYAERSPTLKAESPWAFDFSSRSQLQNDFPSDKMLLPAMCATPMARAKKVQSAHCRRATDSSASFLGEDIGREQLEGKRKHEEEEDQLCDFPVDHPLHAERKGKRRIRTTFTAEQLQELEKIFQVTHYPDVHIRNQLAAKINLPEARVQIWFQNQRAKWRKHEKFGNFGGLQHLTEVDFIPAPKSDITAPSLMPRKFAATIPSTGYYSPLQGQLTTAWLPSTFSYIPHHLELLPFPKPCLFFNVLPAYSAPRSHKMEQSSICASST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U9A3</accession>
    <name>A0A8C2U9A3_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutamate rich 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ERICH6</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015727623.1">
        <property type="nucleotide sequence ID" value="XM_015872137.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U9A3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005032401.1">
        <property type="protein sequence ID" value="ENSCJPP00005023674.1"/>
        <property type="gene ID" value="ENSCJPG00005018739.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107318385"/>
    <dbReference type="KEGG" id="cjo:107318385"/>
    <dbReference type="CTD" id="131831"/>
    <dbReference type="GeneTree" id="ENSGT00940000153655"/>
    <dbReference type="OrthoDB" id="527209at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029281">
        <property type="entry name" value="FAM194_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23093:SF18">
        <property type="entry name" value="GLUTAMATE RICH 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23093">
        <property type="entry name" value="SIMILAR TO CHROMOSOME 3 OPEN READING FRAME 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14977">
        <property type="entry name" value="FAM194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM194 C-terminal" evidence="2">
        <location>
            <begin position="251"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005023674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="491" mass="54486" checksum="5962EF97EA0B01F4" modified="2022-01-19" version="1">MDVPGGAGAGATQKPSQQNEASRLQEQDCTEPPPPGEPSGLDITCAMEFLEEFVELLAQPLRTLPSIGPPAALAYRPEVLRGCLRAEAEEDCAPKCEYCGSVLRPFPSFEDICPPPQKFCCQRNRDLYEFILNERKKHESARDSSISIESHKPHGSDAERHQEKERAYQRQQERQLARQLALLAAEPTPAVAESTSQLGTISYMLSQEPPSPTGWTLMPAKKAAEPEEEEPISYSITCCDFTVMGSRVAKNELLEKYYRHGGKFLTMLPDGTAQIFYPSGNLAVIVVREKKRFVCIVQEDKASNSEIQAVFASNGRSTCYHPHGTVWITMNTAGGQCLDRAGNRVRRWMWPSSTASSGPCAPLSPIFLSLNLHVGVRIVGQDKITVSFLAMGQQAKFNVGTKVQGSQAGQLRVHPQLNEDELLLLALRVKILRLIDKLRGCLNFPSNEQWDKMKPPAYLVTQTLKILYLCKNSDIREELCSSVRAIVKTPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UAH2</accession>
    <name>A0A8C2UAH2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="24">Hephaestin</fullName>
            <ecNumber evidence="3">1.16.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="29" type="primary">CP</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="29" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="29" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="22">Plasma membrane ferroxidase that mediates the extracellular conversion of ferrous/Fe(2+) iron into its ferric/Fe(3+) form. Couples ferroportin which specifically exports ferrous/Fe(2+) iron from cells to transferrin that only binds and shuttles extracellular ferric/Fe(3+) iron throughout the body. By helping iron transfer from cells to blood mainly contributes to dietary iron absorption by the intestinal epithelium and more generally regulates iron levels in the body.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>4 Fe(2+) + O2 + 4 H(+) = 4 Fe(3+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.16.3.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:11149"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="23">Part of a complex composed of SLC40A1/ferroportin, TF/transferrin and HEPH/hephaestin that transfers iron from cells to transferrin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="20">Basolateral cell membrane</location>
            <topology evidence="20">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.16.3.1" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2UAH2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005032424.1">
        <property type="protein sequence ID" value="ENSCJPP00005023696.1"/>
        <property type="gene ID" value="ENSCJPG00005018754.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155866"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047066">
        <property type="term" value="F:phospholipid-hydroperoxide glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04222">
        <property type="entry name" value="CuRO_1_ceruloplasmin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11021">
        <property type="entry name" value="CuRO_2_ceruloplasmin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04224">
        <property type="entry name" value="CuRO_3_ceruloplasmin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04225">
        <property type="entry name" value="CuRO_5_ceruloplasmin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11012">
        <property type="entry name" value="CuRO_6_ceruloplasmin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000009">
        <property type="entry name" value="Ceruloplasmin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000015">
        <property type="entry name" value="Ceruloplasmin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000084">
        <property type="entry name" value="Ceruloplasmin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000002">
        <property type="entry name" value="Hephaestin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048236">
        <property type="entry name" value="Ceruloplasmin-like_CuRO_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF226">
        <property type="entry name" value="CERULOPLASMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="19" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16" id="KW-0406">Ion transport</keyword>
    <keyword evidence="15" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0410">Iron transport</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 25" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="25">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034691139" description="Hephaestin" evidence="25">
        <location>
            <begin position="20"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="28">
        <location>
            <begin position="94"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="26">
        <location>
            <begin position="227"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="28">
        <location>
            <begin position="448"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="28">
        <location>
            <begin position="772"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="27">
        <location>
            <begin position="923"/>
            <end position="1024"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00054029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00065139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00068243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005023696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1049" mass="120006" checksum="BCA5FCE1ADD0E6B7" modified="2022-01-19" version="1">MKLHLLEVLLLFCCYRTRAVTREYYIGIIETAWDYAPGNTDLISGQHFAEEEQAEVFLKRGPQRIGSIYKKAVYTQYTNILYDVIVEKPSWLGFLGPIIKGEVGDSIVIHLKNFASRNYTLHPHGVTYTKENEGAFYPDNTKGFEKRDDAVKPGGQYTYTWDVTEDQGPAKEDADCITRVYHSHIDAPRDVASGLVGPLIICKKGAMNKDNDKYVDAEFILMFSVMDENLSWYLEDNIRTYCSEPSKVDKDDEDFQESNKMHSINGYMYGYLPNLTMCAEDKVKWHLFGMGNEADIHSVYFHGQTLIERHHRVDTINLFPATFIDALMIPRNPGEWLLSCQVNDHVEGGMQALFKVEDCRKSTIDHNETTKIRQYFIAAEEIIWNYGPSALNHFTGQELTADSESSVFFEQSETRIGGSYKKAIYKEYTDGTFTAHKKRLPEEEHLGLLGPVIKAEVEESIRVTFRNNASRPFSIQPHGVSYQKSNEGALYRTASRDTESPASHVSPGATFTYEWNVPEDVGPTDQDPDCLTWLYYSAVDSVRDTNSGLVGPLLVCRRGALLPSAKQKSVTREFFLLATVFDENLSWYLDDNILMFALNPNEIDKDNEDFQESNKMHSINGYMYGNQPGLEMCKGTRKDTANLFPHTFVTAIMKPDSEGIFEVSCLTTDHYRGGMKQKYKVKPCHWGNVDPSLYLHEKTHYIAAIEVEWDYSPNRTWEFERHQYHEESPGNPFLNKEDKFIGSKYKKVVYREYTDHTFSTPKSRAEEEQHLQIQGPLIMSSIGDKINIVFKNLASRPYSIHAHGVKTDSSVVAITNPGETKTYVWKISARSSSERGELHCTAWAYHSTVDIIKDTYSGLIGTLVVCPRHYLPSSHTRKKVHFALLFMVFDENESWYLDENIETYSVNPHLVDKENEEFLESNKMHAINGKVFGNLHGLTMHVGDEVSWYLIAMGNEVDIHTTHFHGHSFNYKQTGVYRADVFDLFPGTFQTVEMIPQNPGTWLLHCHVTDHIHAGMEAIYTVLPEEDKWSLFPRLFNQSKYTSKGTPDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UAS3</accession>
    <name>A0A8C2UAS3_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4537 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC107315893</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015722301.1">
        <property type="nucleotide sequence ID" value="XM_015866815.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015722307.1">
        <property type="nucleotide sequence ID" value="XM_015866821.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015722330.1">
        <property type="nucleotide sequence ID" value="XM_015866844.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UAS3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005035219.1">
        <property type="protein sequence ID" value="ENSCJPP00005025946.1"/>
        <property type="gene ID" value="ENSCJPG00005020281.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107315893"/>
    <dbReference type="KEGG" id="cjo:107315893"/>
    <dbReference type="GeneTree" id="ENSGT00390000012348"/>
    <dbReference type="OrthoDB" id="6241467at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032770">
        <property type="entry name" value="DUF4537"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14343:SF4">
        <property type="entry name" value="DUF4537 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14343">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15057">
        <property type="entry name" value="DUF4537"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4537" evidence="2">
        <location>
            <begin position="64"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="567"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="633"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="571"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="634"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005025946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="694" mass="79273" checksum="F801C00CA813EBC6" modified="2022-01-19" version="1">MPTSHVPCCHTASQALCGSVLPGCPLTRFPVCAWSPDSICMPLISSARRNFIHSSPEASSFIRGARVLARRKADGYYYLGHIAQEVKGSRECFLIEFDKSRALKGSVRLRVQETPLYDILRYKEASQRSLAPGDRVLAPWDANTERFGPGTVVKVMENKQTPSAHSRKGVLVNFWNGQTKEVSSDQALWIPLPLSERIILELQMPLAARQMVVESSLDYPYIVTPGYRASGRYRRGHSGLDCWPGGLRSVQPCAECSCRCTSVPHCCLTACKSSQPTEHKGQRDNSFIPGTCLSKGKLSKKIEEQLSEVRISPSGSVSREEEENEEKSLMTENLPKDAQCRLEEDSGVLGPKKSPQREMAHATMVDPAVSTDSWLLESVDKEEAGSRQQDAGTEAHLKHKHGLFESRVADAPIQPSQRSISVGASALCPFQPQSFFDQVRQSLKKDSLAIESALRIQRPCGTSSVRAGRFTHLNLLKDKSISKSVHNSASQERWKEMDLSKAKIEHKRRQEEERQLKRRQQQEADAVQRQLRRNNQRRRLYQRMLQGLEKQQEHKNGALQHMALLQAAQSERSKKESSLSEEENRKLSHRLQFLRTQRLQRENLLAELNERSFEQEKERLDLLRSRMQSRHMMLTRDSEDQDRQQKQRQAAKRKVFQKRDHLHEKMQKENQRQGDLQQHLREQNLLMLRALLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UB30</accession>
    <name>A0A8C2UB30_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Malignant T-cell-amplified sequence</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MCTS1</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the MCTS1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2UB30"/>
    <dbReference type="Ensembl" id="ENSCJPT00005032509.1">
        <property type="protein sequence ID" value="ENSCJPP00005023777.1"/>
        <property type="gene ID" value="ENSCJPG00005018792.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00550000074964"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002188">
        <property type="term" value="P:translation reinitiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11609">
        <property type="entry name" value="MCT1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21155">
        <property type="entry name" value="PUA_MCTS-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.400.20:FF:000001">
        <property type="entry name" value="Malignant T-cell-amplified sequence 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016437">
        <property type="entry name" value="MCT-1/Tma20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041366">
        <property type="entry name" value="Pre-PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22798:SF0">
        <property type="entry name" value="MALIGNANT T-CELL-AMPLIFIED SEQUENCE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22798">
        <property type="entry name" value="MCT-1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17832">
        <property type="entry name" value="Pre-PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005067">
        <property type="entry name" value="Tma_RNA-bind_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0341">Growth regulation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PUA" evidence="6">
        <location>
            <begin position="95"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005023777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="183" mass="20755" checksum="0A0E5BE9A76EA23E" modified="2022-01-19" version="1">MFLLGRFDEKENVSNCIQLKTSVIKGIKNQLIDQFPVIEPWLNQIMPKKDPVKIVRCHEHIEILTVNGELLFFRQREGIFYPTLRLLHKYPFILPHQQVDKGAIKFVLSGANIMCPGLTSPGAKLYPAAVDTVVAIMAEGKQHALCVGVMKMSADDIEKVNKGIGIENIHYLNDGLWHMKTYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UB81</accession>
    <name>A0A8C2UB81_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="24">Solute carrier family 15 member 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="27">Intestinal H(+)/peptide cotransporter</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="25">Oligopeptide transporter, small intestine isoform</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="26">Peptide transporter 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="48" type="primary">SLC15A1</name>
    </gene>
    <organism evidence="48 49">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="48" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="48" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="48" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="28">Electrogenic proton-coupled amino-acid transporter that transports oligopeptides of 2 to 4 amino acids with a preference for dipeptides. Transports neutral and monovalently charged peptides with a proton to peptide stoichiometry of 1:1 or 2:1. Primarily responsible for the absorption of dietary di- and tripeptides from the small intestinal lumen. Mediates transepithelial transport of muramyl and N-formylated bacterial dipeptides contributing to recognition of pathogenic bacteria by the mucosal immune system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="42">
            <text>L-alanyl-L-aspartate(out) + 2 H(+)(out) = L-alanyl-L-aspartate(in) + 2 H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:71695"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:74363"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="42">
            <dbReference type="Rhea" id="RHEA:71696"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="44">
            <text>L-alanyl-L-leucyl-L-alanine(out) + H(+)(out) = L-alanyl-L-leucyl-L-alanine(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:71723"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:191212"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="44">
            <dbReference type="Rhea" id="RHEA:71724"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="36">
            <text>L-alanyl-L-lysine(out) + H(+)(out) = L-alanyl-L-lysine(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:72611"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:192470"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="36">
            <dbReference type="Rhea" id="RHEA:72612"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>L-alanyl-L-proline(out) + H(+)(out) = L-alanyl-L-proline(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:64420"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:155848"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="29">
            <dbReference type="Rhea" id="RHEA:64421"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="37">
            <text>L-alanyl-L-prolylglycine(out) + H(+)(out) = L-alanyl-L-prolylglycine(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:64432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:155849"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="37">
            <dbReference type="Rhea" id="RHEA:64433"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="32">
            <text>L-alanyl-L-valine(out) + H(+)(out) = L-alanyl-L-valine(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:72615"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:192471"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="32">
            <dbReference type="Rhea" id="RHEA:72616"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>L-aspartyl-glycine(out) + 2 H(+)(out) = L-aspartyl-glycine(in) + 2 H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:71683"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:191203"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="30">
            <dbReference type="Rhea" id="RHEA:71684"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="40">
            <text>L-leucyl-L-leucine(out) + H(+)(out) = L-leucyl-L-leucine(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:71715"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:191208"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="40">
            <dbReference type="Rhea" id="RHEA:71716"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="41">
            <text>L-leucyl-L-proline(out) + H(+)(out) = L-leucyl-L-proline(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:64424"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:155847"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="41">
            <dbReference type="Rhea" id="RHEA:64425"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>L-lysyl-glycine(out) + H(+)(out) = L-lysyl-glycine(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:71679"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:191202"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="31">
            <dbReference type="Rhea" id="RHEA:71680"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="31">
            <dbReference type="Rhea" id="RHEA:71681"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="43">
            <text>L-methionyl-L-phenylalanyl-L-methionine(out) + H(+)(out) = L-methionyl-L-phenylalanyl-L-methionine(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:71719"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:191211"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="43">
            <dbReference type="Rhea" id="RHEA:71720"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="35">
            <text>L-phenylalanyl-L-leucine(out) + H(+)(out) = L-phenylalanyl-L-leucine(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:71699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:190710"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="35">
            <dbReference type="Rhea" id="RHEA:71700"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="38">
            <text>L-phenylalanyl-L-phenylalanine(out) + H(+)(out) = L-phenylalanyl-L-phenylalanine(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:71707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:191205"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="38">
            <dbReference type="Rhea" id="RHEA:71708"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="34">
            <text>L-tyrosylglycine(out) + H(+)(out) = L-tyrosylglycine(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:71711"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:191210"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="34">
            <dbReference type="Rhea" id="RHEA:71712"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="39">
            <text>N(alpha)-formyl-L-methionyl-L-leucyl-L-phenylalanine(out) + 2 H(+)(out) = N(alpha)-formyl-L-methionyl-L-leucyl-L-phenylalanine(in) + 2 H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:75399"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:194314"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="33">
            <text>N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(out) + 2 H(+)(out) = N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(in) + 2 H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:64408"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:155830"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a dipeptide(out) + H(+)(out) = a dipeptide(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:64392"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:90799"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:64393"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>an L-amino acid tripeptide(out) + H(+)(out) = an L-amino acid tripeptide(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:64400"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:155837"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:64401"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>carnosine(out) + H(+)(out) = carnosine(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:64404"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57485"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:64405"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>glycyl-L-aspartate(out) + 2 H(+)(out) = glycyl-L-aspartate(in) + 2 H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:71687"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:191204"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:71688"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="19">
            <dbReference type="Rhea" id="RHEA:71689"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>glycyl-L-glutamate(out) + 2 H(+)(out) = glycyl-L-glutamate(in) + 2 H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:71691"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73784"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:71692"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>glycyl-L-glutamine(out) + H(+)(out) = glycyl-L-glutamine(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:71671"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:74392"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:71672"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="21">
            <dbReference type="Rhea" id="RHEA:71673"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>glycyl-L-leucine(out) + H(+)(out) = glycyl-L-leucine(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:71675"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:143163"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:71676"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>glycyl-L-proline(out) + H(+)(out) = glycyl-L-proline(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:64428"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73779"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:64429"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>glycyl-sarcosine(out) + H(+)(out) = glycyl-sarcosine(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:64396"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:155838"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:64397"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>glycylglycyl-L-isoleucine(out) + H(+)(out) = glycylglycyl-L-isoleucine(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:64436"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:155850"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:64437"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>glycylglycyl-L-proline(out) + H(+)(out) = glycylglycyl-L-proline(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:64440"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:155851"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:64441"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="45">Membrane</location>
            <topology evidence="45">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 45">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2UB81"/>
    <dbReference type="Ensembl" id="ENSCJPT00005033514.1">
        <property type="protein sequence ID" value="ENSCJPP00005024619.1"/>
        <property type="gene ID" value="ENSCJPG00005019045.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155995"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005903">
        <property type="term" value="C:brush border"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071916">
        <property type="term" value="F:dipeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015333">
        <property type="term" value="F:peptide:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005427">
        <property type="term" value="F:proton-dependent oligopeptide secondary active transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042937">
        <property type="term" value="F:tripeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140206">
        <property type="term" value="P:dipeptide import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000049">
        <property type="entry name" value="Solute carrier family 15 member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000205">
        <property type="entry name" value="Solute carrier family 15 oligopeptide transporter member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018456">
        <property type="entry name" value="PTR2_symporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01022">
        <property type="entry name" value="PTR2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01023">
        <property type="entry name" value="PTR2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 47" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="49" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0769">Symport</keyword>
    <keyword evidence="6 45 47" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 47" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 45" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="47">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="47">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="47">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="47">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="47">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="47">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="47">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="47">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="47">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="47">
        <location>
            <begin position="612"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="47">
        <location>
            <begin position="644"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="46">
        <location>
            <begin position="678"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="46">
        <location>
            <begin position="680"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00035846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00036064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00036337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00036347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00036515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00036681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00036857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00036905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00041093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00041329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00042837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00043099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00045775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00050347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00050357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00050377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00050390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="ARBA" id="ARBA00050915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="ARBA" id="ARBA00051307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="35">
        <source>
            <dbReference type="ARBA" id="ARBA00051459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="36">
        <source>
            <dbReference type="ARBA" id="ARBA00051565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="37">
        <source>
            <dbReference type="ARBA" id="ARBA00051580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="38">
        <source>
            <dbReference type="ARBA" id="ARBA00051804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="39">
        <source>
            <dbReference type="ARBA" id="ARBA00052040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="40">
        <source>
            <dbReference type="ARBA" id="ARBA00052105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="41">
        <source>
            <dbReference type="ARBA" id="ARBA00052153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="42">
        <source>
            <dbReference type="ARBA" id="ARBA00052370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="43">
        <source>
            <dbReference type="ARBA" id="ARBA00052549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="44">
        <source>
            <dbReference type="ARBA" id="ARBA00052590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="45">
        <source>
            <dbReference type="RuleBase" id="RU003755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="46">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="47">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="48">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005024619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="49">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="703" mass="77795" checksum="2F757C1C6056B84F" modified="2022-01-19" version="1">TAAKSKSKGRSVPSCFGYPLSIAFIVVNEFCERFSYYGMRAVLVLYFKYFLRWDDNFSTAIYHTFVALCYLTPILGALIADSWLGKFKTIVSLSIVYTIGQAVMAVSSINDMTDHNRDGNPDNIAVHIALSMTGLILIALGTGGIKPCISAFGGDQFEDHQEKQRSRFFSIFYLSINAGSLISTVITPILRAQECGIHSKQQCYPLAFGVPAALMAVSLVVFIAGSGMYKKVQPQGNIMVRVFKCIGFAIKNRFRHRSKEYPKREHWLDWASEKYDKRLIAQTKMVLKVLFLYIPLPMFWALFDQQGSRWTLQATTMDGDFTVNPILIIIMVPVVDAVIYPLIQKCKINFTPLRKITVGMFLAGLAFVAAALLQVQIDKTLPVFPASGQAQVKIINLGSSNAEVTFLPDLQNVTVLPMESTDYRMFETSQLKSVIVNFGSENRSQSIDSASSNTHTVTIKNTAAGIVSSLHSDNFTSKPEEGKTLIRFVNNLPQTVNITMGGTAFGILEETSISDYSPFAGGRTNEIVVTAGSTNCTTTSEAFGYGGAYTIIINACSQDVTQLRYIEDIQPNTVHMAWQIPQYFILTCAEVVFSVTGLEFSYSQAPSNMKSVLQAGWLLTVAVGNIIVLIVAGASKLSEQWAEYVLFAALLFAVCIIFAVMAYFYTYTDPNEVEAQLDEEEKKKQIKQDPDSYGKESEAVSRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UBK7</accession>
    <name>A0A8C2UBK7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">chitinase</fullName>
            <ecNumber evidence="4">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">CHIA</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2UBK7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005032767.1">
        <property type="protein sequence ID" value="ENSCJPP00005023981.1"/>
        <property type="gene ID" value="ENSCJPG00005018955.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154557"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019900">
        <property type="term" value="F:kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032722">
        <property type="term" value="P:positive regulation of chemokine production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002532">
        <property type="term" value="P:production of molecular mediator involved in inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000081">
        <property type="entry name" value="Chitinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF188">
        <property type="entry name" value="ACIDIC MAMMALIAN CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="6" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="domain" description="GH18" evidence="16">
        <location>
            <begin position="1"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="15">
        <location>
            <begin position="247"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="209"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005023981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="296" mass="31859" checksum="19A5DF834CFA35CC" modified="2022-01-19" version="1">MLAAFEQEARLSNIQADFSSTLPGGGYLDYFHVMTYDFHGSWDGQTGENSPLYSGNNAYLSVDYAMNYWKSNGAPAEKLLVGFPTYGHSFILKDPHSITLRALGHPKHPPLGPAGPLTNWSWRVSGCTLSSYFQAWDAPQDVPYAYKSTEWVGYDNIKSFNIKTDWLKKNNYGGAMVWSLDMDDFTGTFCKQGKYPLITTLKNALGQQSSSCVPPAQPNPPITAAPSTGSGSGSGSSGSNTGSSGGSGFCAGKANGIYADPTNKSKFYNCNNGETFTQTCQAGLVFDSSCSCCNWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UBT4</accession>
    <name>A0A8C2UBT4_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Formin binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">FNBP1</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cell cortex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FNBP1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2UBT4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005035530.1">
        <property type="protein sequence ID" value="ENSCJPP00005026216.1"/>
        <property type="gene ID" value="ENSCJPG00005020409.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183047"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07676">
        <property type="entry name" value="F-BAR_FBP17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11629">
        <property type="entry name" value="HR1_FBP17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12071">
        <property type="entry name" value="SH3_FBP17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000002">
        <property type="entry name" value="Formin-binding protein 1-like isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000017">
        <property type="entry name" value="Formin-binding protein 1-like isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037449">
        <property type="entry name" value="FNBP1_F-BAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035492">
        <property type="entry name" value="FNBP1_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011072">
        <property type="entry name" value="HR1_rho-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057870">
        <property type="entry name" value="HR1_TOCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735">
        <property type="entry name" value="FCH AND DOUBLE SH3 DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735:SF13">
        <property type="entry name" value="FORMIN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25610">
        <property type="entry name" value="HR1_TOCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UBW9</accession>
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        <lineage>
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            <taxon>Vertebrata</taxon>
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            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
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            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
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        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
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                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
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                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
    </reference>
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        <subcellularLocation>
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    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1821" mass="199607" checksum="D19C9938FB103C5F" modified="2022-01-19" version="1">MTTETGPDSEVKNVQEEAPQQQLEAATHGRAATAAGTASRDAEANEKPGAQPDSQHTEPGTDMEEKDYSETDGLSDKTTPSKTQKSPQKINKKVKSALCRVTLLDASEYECEVEKHARGQVLFDMVCEHLNLLEKDYFGLTFCDSDSQKVSLGDPSAATPLLSGSWNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCSFVTHALLGSYAVQAELGDYDAEEHVGNYVSELRFAPNQTRELEERIMELHKTYRGMTPGEAEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPKILKISYKRSNFYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSPEPPPKGFLVMGSKFRYSGRTQAQTRQASALIDRPAPFFERSSSKRYTMSRSLDGEFSRPASVSENHDTGAEGEKQEEDGEFGSGRRSETEDEEVTTPTKIKELKPEHETTPRHKQEFLDKPEDVLLKHQASINELKRTLKEPNSKLVHRDRDRRLPSSPASSSPKMEEDTLDDFASEHGVSLSMESFTQKSLVSSPEGSEHWVFIERETTRLEEVALKKALRVKKEERRAGTSEVKTSVSMSKVEMAVGKAKEVAGQEQPADEHLDTWKRAKMIASPEDFESVWEDETYEKETGEEPSTEAKCLAHERAEEKSKERVEGVTRSELGLSRPHQKPEERQRAETLGPGPLHGENMMVSEEPVSASFRKQDARAPTAATEVIKIKVKSSDDNTETSATQRIIYLGDLEGEEDNKMHLLTEAGGQLGSAVRQETVVNRPGEGPGPTACLGERSQCSSSVYAQQKAVSEKPSVVPDQPETGCDETSPSGHSPLEQEEGFSVQQEQASVSLTGCKTLEEDKGTLCSQEEGSDEKDLQRSVRGLRPCTLKRADDPRQSPGQNPTAGEQWGLEVSTEEWELSERSLSGEREEKSSTVVLQMEEIETKLPLSGVPQQSCPRATVGLGEGEPSTPTPGILPQQLSPAEPAQEMELEGKDLSQNTSLVRGVGTPEDMNPSAEVACKEASPAVGKEAFEDTSPVTEVKIPRDVSPESVKKKQDMHFATQKTYQDANAIARGPHQSKGSAAETIPLRDPVTGEVVQNSDPTAAKGTLRNTEEVCQEEQLVIKGLSQNVEPTSGELIGDEGMEQLPPKAEEPEQKAETIIGHLPQKGPQSGGVLHTADTKAQEPACDLEFNAGQALQGRSSMAGETARNSELALEQSLQSPGDADVLHSHSSITGLCQGSKLYQLSTFVCEGGEEVQVSSGIEKRESGPLMYTAATEAVRQEHRGVTEAPLLGSWQDGDSYKKTSVASKIKMFEQNESEQWTAQEGQEHVHASETETTAKAKGKTNLSQDTTLNTAPITPAVKAGAPVGSLSSVDSFAFRQGAGPGDSSQLLSLKEGVFVDLEHEGEDSADLASSDSGCELTLAEAVVTSNELSGWKVHAHVVAAMPHSAHCLHVSPSLCLIQRAGLREGTEEKVKPPRHRAPESDTGDEEQDQEKDSVFLKDNHLAIERKCSSITVSSTSSLEAEVDFTVISDFHGTAFEDISRSLPELDKDKTEMEDEGLISFQQTDRVVPGLEEDGRAREKVAQPSPDISQLEVHREVVLPRLFCTPSKALPNSLGFLCLWQVEGGMPGSRDASASVRAVTTETTPTTSVSWWKGAGNLGPGDQLLFSVMQISSSSAGKELITSIFSATAETLSTSTTTHVTKTVKGGFSETRIEKRIIITGDEDVDQDQALALAIKEAKLQHPDMLVTKAVVYRETEPSPEERDKKPQVGGEVIRYNLCLLCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UC85</accession>
    <name>A0A8C2UC85_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Tumor necrosis factor ligand superfamily member 11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Osteoclast differentiation factor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Osteoprotegerin ligand</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Receptor activator of nuclear factor kappa-B ligand</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">TNF-related activation-induced cytokine</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">TNFSF11</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the tumor necrosis factor family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015707221.1">
        <property type="nucleotide sequence ID" value="XM_015851735.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UC85"/>
    <dbReference type="Ensembl" id="ENSCJPT00005034132.1">
        <property type="protein sequence ID" value="ENSCJPP00005025063.1"/>
        <property type="gene ID" value="ENSCJPG00005019710.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107308113"/>
    <dbReference type="KEGG" id="cjo:107308113"/>
    <dbReference type="CTD" id="8600"/>
    <dbReference type="GeneTree" id="ENSGT01130000278318"/>
    <dbReference type="OrthoDB" id="8783336at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005164">
        <property type="term" value="F:tumor necrosis factor receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045453">
        <property type="term" value="P:bone resorption"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055074">
        <property type="term" value="P:calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990830">
        <property type="term" value="P:cellular response to leukemia inhibitory factor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007254">
        <property type="term" value="P:JNK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002548">
        <property type="term" value="P:monocyte chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001503">
        <property type="term" value="P:ossification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036035">
        <property type="term" value="P:osteoclast development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002158">
        <property type="term" value="P:osteoclast proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038001">
        <property type="term" value="P:paracrine signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043491">
        <property type="term" value="P:phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045780">
        <property type="term" value="P:positive regulation of bone resorption"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043123">
        <property type="term" value="P:positive regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051466">
        <property type="term" value="P:positive regulation of corticotropin-releasing hormone secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070374">
        <property type="term" value="P:positive regulation of ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071812">
        <property type="term" value="P:positive regulation of fever generation by positive regulation of prostaglandin secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034112">
        <property type="term" value="P:positive regulation of homotypic cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046330">
        <property type="term" value="P:positive regulation of JNK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901224">
        <property type="term" value="P:positive regulation of non-canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001206">
        <property type="term" value="P:positive regulation of osteoclast development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051897">
        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050870">
        <property type="term" value="P:positive regulation of T cell activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033209">
        <property type="term" value="P:tumor necrosis factor-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00184">
        <property type="entry name" value="TNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.40:FF:000008">
        <property type="entry name" value="Tumor necrosis factor ligand superfamily member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006052">
        <property type="entry name" value="TNF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11471">
        <property type="entry name" value="TUMOR NECROSIS FACTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11471:SF3">
        <property type="entry name" value="TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00229">
        <property type="entry name" value="TNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00207">
        <property type="entry name" value="TNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50049">
        <property type="entry name" value="THD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0202">Cytokine</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="9" id="KW-0221">Differentiation</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="THD" evidence="20">
        <location>
            <begin position="247"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00074589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00077116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00077180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00077877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00081387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005025063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="400" mass="45016" checksum="137865166D66C855" modified="2022-01-19" version="1">MLLQGGELLSGLGFGEKRSPLLGNSWAGCLHPLALCYLASPKEVWGCREFASQGQVVAACLASYQLFTCSANTASGYLWNLRGEIVVGCTCTVVEAHTAYLLLHACASIGSDACLTLAGSGFWVLILQETRSAGNHPWYWFKEKIESQKQDFMVKKMDPSRISKEDAHCVRMLFRSQESIDLQDSPFENQEVKLMPESCRRMKQALQRAVQKEVQRILGKEPPRPEKAAMEAIGLELYRRNKPEKQPFAHLIIDDKNIPTGTRKVNLTSWHHDKGQANLSNMTFSDGKLIVNQDGFYYLYANICFRHHETSGNLTKRGLQLMVYMTKTNLKIRRSEVLMKGGSTKYWSGNSEFHFYSVNIGGFLKLKTGDMISIQVSNPLLLDSSQEATYFGAFKVRDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UCZ2</accession>
    <name>A0A8C2UCZ2_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">WASP homolog associated with actin, golgi membranes and microtubules</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">WHAMM</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2UCZ2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005035123.1">
        <property type="protein sequence ID" value="ENSCJPP00005025869.1"/>
        <property type="gene ID" value="ENSCJPG00005020213.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00510000046704"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033116">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071933">
        <property type="term" value="F:Arp2/3 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048041">
        <property type="term" value="P:focal adhesion assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030032">
        <property type="term" value="P:lamellipodium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051127">
        <property type="term" value="P:positive regulation of actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031738">
        <property type="entry name" value="JMY/WHAMM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031808">
        <property type="entry name" value="JMY/WHAMM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23330">
        <property type="entry name" value="P300 TRANSCRIPTIONAL COFACTOR JMY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23330:SF6">
        <property type="entry name" value="WASP HOMOLOG-ASSOCIATED PROTEIN WITH ACTIN, MEMBRANES AND MICROTUBULES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15871">
        <property type="entry name" value="JMY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15920">
        <property type="entry name" value="WHAMM-JMY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51082">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WH2" evidence="8">
        <location>
            <begin position="695"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="482"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="600"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="739"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="491"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="616"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005025869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="761" mass="86921" checksum="00BAED4720C66A22" modified="2022-01-19" version="1">MDPQPDSLEGWVAVRDTAFTEPQPPPRLRFLVGWNEVEGAFAVTCHCRAETAERTPQSWAGLFSTPALLGVHRQLAAVCPRLEPALPALPPALPGSSGGLWAVLFPGGAAPDEAEVSELCRQLERYLGWALELCGGRVLLDVLFAADSRRDDEYFESLHEFRGTALRGHLARAKDALRRVLQLHKNADTMVALMKVYEEEDEAYQDLITMATQFYQYLLQPFRDMRELATLCKLEILKSLQYDNLGPKRVAALQKDAEEWTKRAETAVCSIQDITVKYFKETVKALSAMHKQMEQDQERFGKATWASALPRLENLKCMLAKETLQHLRARELCLKHKRASIQKNMENLSEQEENVTVAEELEIYYYETQLELYNVQLDILKHEEMLLIVQLDTLRRQIKEKQDEVVYYDTRENPEELKVIEQTMEHHYANLSEMTVLRQKTKQLETKRGTVCARRAYLRNKKDQCEASHRQRLQQAEELKKRFQQHHSIQIKRDKQKEEEKKKKAWISQERQKTLERLKTFREKCPAHVVLKTSHPEPLSPRLPRNITQKAAVGHPPPPSRARPAPEQPKSLLLVEAQVSETSQQDTPEDIPAQSFITTGDSKQQNHSEELISLSLPPPPPPPPLPPPPAPPLPPPLPLHLKTRPTIEDKPLSLRSDDFSENLSVAGTMDEVLASLKRGEVHLRKVEQPNPYASVKDNILSAIRQGVKLRKVNRDTEKDASKESTNELERSIKAAIQRIKKVSADSEEEENNDQNNGEWDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UES2</accession>
    <name>A0A8C2UES2_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">ST6GALNAC6</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a ganglioside GM1b (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GD1alpha (d18:1(4E)) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41968"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:78568"/>
            <dbReference type="ChEBI" id="CHEBI:78569"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:41969"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 29 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2UES2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005034541.1">
        <property type="protein sequence ID" value="ENSCJPP00005025388.1"/>
        <property type="gene ID" value="ENSCJPG00005019934.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160114"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001665">
        <property type="term" value="F:alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001574">
        <property type="term" value="P:ganglioside biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009100">
        <property type="term" value="P:glycoprotein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006677">
        <property type="term" value="P:glycosylceramide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1480.20">
        <property type="entry name" value="Glycosyl transferase family 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001675">
        <property type="entry name" value="Glyco_trans_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038578">
        <property type="entry name" value="GT29-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45906">
        <property type="entry name" value="ALPHA-N-ACETYL-NEURAMINYL-2,3-BETA-GALACTOSYL-1, 3-N-ACETYL-GALACTOSAMINIDE ALPHA-2,6-SIALYLTRANSFERASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45906:SF6">
        <property type="entry name" value="ALPHA-N-ACETYLGALACTOSAMINIDE ALPHA-2,6-SIALYLTRANSFERASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00777">
        <property type="entry name" value="Glyco_transf_29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0730">Sialic acid</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00043744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005025388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="246" mass="27078" checksum="2117FE5D87FB9152" modified="2022-01-19" version="1">GGPGSASQFCLPAPPPPGSVPPSQRGAPGSARPRCGTRRRHQRAAVFVLLFALLMLLIIYSSSSGTEVFPYSALRGRARRPPNLRHWRVSSGYLPVSGNKTLSAHCHQCAIVTSSSHLLGTHLGAEIDQTECTIRMNDAPTTGYEADVGNKTTFRVVAHSSIYRVLKRPQEFVNKTPETILIFWGPPAKMQKGLLKIIQRVGASFPNMTAYVVSPHRMKQFDELFRGETGKDRYRELLIPSLWSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UGD2</accession>
    <name>A0A8C2UGD2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription factor MafB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">MAFB</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bZIP family. Maf subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2UGD2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005036363.1">
        <property type="protein sequence ID" value="ENSCJPP00005026841.1"/>
        <property type="gene ID" value="ENSCJPG00005020858.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160486"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021599">
        <property type="term" value="P:abducens nerve formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035284">
        <property type="term" value="P:brain segmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903575">
        <property type="term" value="P:cornified envelope assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042472">
        <property type="term" value="P:inner ear morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030216">
        <property type="term" value="P:keratinocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045647">
        <property type="term" value="P:negative regulation of erythrocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045671">
        <property type="term" value="P:negative regulation of osteoclast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007585">
        <property type="term" value="P:respiratory gaseous exchange by respiratory system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007584">
        <property type="term" value="P:response to nutrient"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021571">
        <property type="term" value="P:rhombomere 5 development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021572">
        <property type="term" value="P:rhombomere 6 development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007379">
        <property type="term" value="P:segment specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033077">
        <property type="term" value="P:T cell differentiation in thymus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048538">
        <property type="term" value="P:thymus development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd14718">
        <property type="entry name" value="bZIP_Maf_large"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000016">
        <property type="entry name" value="MAF bZIP transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004826">
        <property type="entry name" value="bZIP_Maf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013592">
        <property type="entry name" value="Maf_TF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008917">
        <property type="entry name" value="TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024874">
        <property type="entry name" value="Transcription_factor_Maf_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10129">
        <property type="entry name" value="TRANSCRIPTION FACTOR MAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10129:SF10">
        <property type="entry name" value="TRANSCRIPTION FACTOR MAFB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03131">
        <property type="entry name" value="bZIP_Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08383">
        <property type="entry name" value="Maf_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47454">
        <property type="entry name" value="A DNA-binding domain in eukaryotic transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="11">
        <location>
            <begin position="226"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="35"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="150"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="251"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="168"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005026841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="369" mass="41776" checksum="B050B652327BFDE6" modified="2022-01-19" version="1">MAGELSIGAELPTSPLAMEYVNDFDLMKFDVKKEPLGRNDRSGRHCTRLQPAGSVSSTPISTPCSSVPSSPSFSPTEQKTHLEDLYWMANSYQQMNPEALNLTPEDAVEALIGSHQVSQQLQGFESFRAHHHHHHHHQHHHHQYPAVTHEDLAGSGHPHHHHHHHHQASPTPSTSSSSSQQLQTSHQQHPPSSSVEDRFSDDQLVSMSVRELNRQLRGVSKEEVIRLKQKRRTLKNRGYAQSCRYKRVQQKHHLENEKTQLIQQVEQLKQEVTRLARERDAYKLKCEKLASNGFREAGSTSDNPSSPEFFMKRKQNIKQSNISAGWLYGLVGIKEILKGGGGGRKSYGHFAFGKREGGKKGNFVYLVHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UGX6</accession>
    <name>A0A8C2UGX6_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Alpha-amylase</fullName>
            <ecNumber evidence="5 14">3.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC107317338</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>Endohydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1-&gt;4)-alpha-linked D-glucose units.</text>
            <dbReference type="EC" id="3.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>chloride</name>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="5 14"/>
    <dbReference type="RefSeq" id="XP_032302017.1">
        <property type="nucleotide sequence ID" value="XM_032446126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UGX6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005037510.1">
        <property type="protein sequence ID" value="ENSCJPP00005027798.1"/>
        <property type="gene ID" value="ENSCJPG00005021502.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107317338"/>
    <dbReference type="GeneTree" id="ENSGT00940000154802"/>
    <dbReference type="OrthoDB" id="550577at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11317">
        <property type="entry name" value="AmyAc_bac_euk_AmyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000020">
        <property type="entry name" value="Pancreatic alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000056">
        <property type="entry name" value="Pancreatic alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031319">
        <property type="entry name" value="A-amylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006046">
        <property type="entry name" value="Alpha_amylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43447">
        <property type="entry name" value="ALPHA-AMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00110">
        <property type="entry name" value="ALPHAAMYLASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00632">
        <property type="entry name" value="Aamy_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="11 14" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0868">Chloride</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12 14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034974451" description="Alpha-amylase" evidence="15">
        <location>
            <begin position="17"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="17">
        <location>
            <begin position="27"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-amylase C-terminal" evidence="16">
        <location>
            <begin position="424"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="RuleBase" id="RU361134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005027798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="513" mass="57996" checksum="5545ADFF09016F30" modified="2022-01-19" version="1">MGVRFLLLFIVGLCRAQYDPNTRPGRTSIVHLFEWRWADIALECERYLAPNGFGGVQISPPNENLVIGDPSRPWWERYQPVSYKLCTRSGNETEFRDMVTRCNNVGVYVYADAVINHMCGGNAGAGNHSTCGSFFNAKTKEFPAVPYSAWDFNDAKCKSRSGDIEDYRDLSQVRNCRLVNLLDLALEKNYVRSRITEYMNYLIDIGVAGFRIDAAKHMWPGDVKAVLEELKDLNRKWFPAGAKPFIYQEVIDLGGEPITDSQYFGNGRVTEFKYGAKLGTVMRKWNGEKMAYLKNWGEGWGFVPSDTALVFVDNHDNQRGHGAGGASILTFWDARLYKMAVGFMLAHPYGFTRVMSSYRWPRYFQNGVDINNWVGPPSNSDGSTKSVPINPDTTCGNDWVCEHRWRQIRNMVIFRNVVDGQPFSNWWDNGSNQVAFGRGNRGFIAFNNDDWYMNVNLQTGLPAGTYCDVISGQKEGNTCTGKQVYISSDGMANFQISNSEEDPFVAIHVDAML</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UKG5</accession>
    <name>A0A8C2UKG5_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Nucleoside diphosphate kinase</fullName>
            <ecNumber evidence="14">2.7.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">NME2</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:18113"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4 12 13">Belongs to the NDK family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="14"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2UKG5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005037353.1">
        <property type="protein sequence ID" value="ENSCJPP00005027667.1"/>
        <property type="gene ID" value="ENSCJPG00005021419.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161569"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001726">
        <property type="term" value="C:ruffle"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0005524">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120225">
        <property type="term" value="F:coenzyme A binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001216">
        <property type="term" value="F:DNA-binding transcription activator activity"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0004673">
        <property type="term" value="F:protein histidine kinase activity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045618">
        <property type="term" value="P:positive regulation of keratinocyte differentiation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042304">
        <property type="term" value="P:regulation of fatty acid biosynthetic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04413">
        <property type="entry name" value="NDPk_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.141:FF:000015">
        <property type="entry name" value="Nucleoside diphosphate kinase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00451">
        <property type="entry name" value="NDP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023005">
        <property type="entry name" value="Nucleoside_diP_kinase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001908">
        <property type="entry name" value="PRK00668.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11349">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00469">
        <property type="entry name" value="NDPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51374">
        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside diphosphate kinase-like" evidence="15">
        <location>
            <begin position="27"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="12">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
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            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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    <evidence type="ECO:0000256" key="12">
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU004013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
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            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005027667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="175" mass="19774" checksum="32876EF75A9F933D" modified="2022-01-19" version="1">RIEPSSRPRPGSPRRVLVFRSAMAANCERTFIAIKPDGVQRGLVGEIIKRFEQKGFKLVAMKFVHASEELLKQHYIDLKDRPFYPGLVKYMNSGPVVAMVWEGLNVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRNIIHGSDSVESAQKEINLWFKAAELIDYKPCAHDWIYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y5P0</accession>
    <name>A0A8C2Y5P0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y5P0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005002965.1">
        <property type="protein sequence ID" value="ENSCJPP00005001766.1"/>
        <property type="gene ID" value="ENSCJPG00005001799.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163237"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000003">
        <property type="entry name" value="Transmembrane serine protease 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF17">
        <property type="entry name" value="SUPPRESSOR OF TUMORIGENICITY 14 PROTEIN HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S1" evidence="5">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005001766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="187" mass="20895" checksum="7B55322155DB7310" modified="2022-01-19" version="1">MSHPHKWTATFGALLKPPTLKRSVKTIIIHELYRYPEHDYDIALVKLSKQVEFTSNIHRVCLPEPSQTFPYNIYAVITGWGALTNDGPTPNALQEATVKLIDSDTCNRKEVYDGDITPRMLCAGYLEGGVDACQGDSGGPLVTPDSRLMWYLVGIVSWGDECAKPNKPGVYTRVTYFRDWITSKTGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y7C3</accession>
    <name>A0A8C2Y7C3_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Aquaporin-7-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC107305742</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>H2O(in) = H2O(out)</text>
            <dbReference type="Rhea" id="RHEA:29667"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>glycerol(in) = glycerol(out)</text>
            <dbReference type="Rhea" id="RHEA:29675"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015703753.1">
        <property type="nucleotide sequence ID" value="XM_015848267.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y7C3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005009321.1">
        <property type="protein sequence ID" value="ENSCJPP00005005818.1"/>
        <property type="gene ID" value="ENSCJPG00005005505.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107305742"/>
    <dbReference type="KEGG" id="cjo:107305742"/>
    <dbReference type="GeneTree" id="ENSGT00940000159054"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome Z"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015254">
        <property type="term" value="F:glycerol channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015204">
        <property type="term" value="F:urea transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070295">
        <property type="term" value="P:renal water absorption"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00333">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1080.10:FF:000005">
        <property type="entry name" value="Aquaporin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050363">
        <property type="entry name" value="MIP/Aquaporin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00861">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829">
        <property type="entry name" value="AQUAPORIN OR AQUAGLYCEROPORIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829:SF15">
        <property type="entry name" value="AQUAPORIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02019">
        <property type="entry name" value="AQUAPORIN7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005005818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="285" mass="30546" checksum="64470301ACB450D8" modified="2022-01-19" version="1">MLKKIQKRLTIHNSSVRELLAEALGTYVLMVLGLSSVAQVVLGKGKFGQYLSINVGFGIGVTMGIHAAGGISGAHLNAAITFTQCVFGNLPWRKLPAYLLGQFLGSFLAAATIFGLYYDALYDYTKGNFTVTGPTATASIFSTYPAPYMSLAGGFFTEFMATIMLFLGVLVIYDENNNGALKGTQALLTGILVLGIGMGMGMNTGYAINPSRDLPPRIFTAIAGWGVDVFTAGNHWWWVPLVAPVLGSLAGGLIYKILIDIHNQHVQEHGNEKEQTQTVIESSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y7G1</accession>
    <name>A0A8C2Y7G1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">catechol O-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">TOMT</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.6" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y7G1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005009017.1">
        <property type="protein sequence ID" value="ENSCJPP00005005578.1"/>
        <property type="gene ID" value="ENSCJPG00005005309.1"/>
    </dbReference>
    <dbReference type="KEGG" id="cjo:107308547"/>
    <dbReference type="GeneTree" id="ENSGT00940000161220"/>
    <dbReference type="OrthoDB" id="186626at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016206">
        <property type="term" value="F:catechol O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042424">
        <property type="term" value="P:catecholamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042417">
        <property type="term" value="P:dopamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007605">
        <property type="term" value="P:sensory perception of sound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000054">
        <property type="entry name" value="Catechol O-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43836">
        <property type="entry name" value="CATECHOL O-METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43836:SF1">
        <property type="entry name" value="TRANSMEMBRANE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0128">Catecholamine metabolism</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-1009">Hearing</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0531">Neurotransmitter degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005005578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="256" mass="28755" checksum="BCBDAC1E8F0CEB87" modified="2022-01-19" version="1">MVSPAIALAFLPFLITLLIRYRHYLVLLYRAALLPWLQDRLTGVPREQRAFQYVLSHAIPGDPQHILLTFDQWSYNCEHLSCVGPLKGKIVERLLCERAPRSVLELGTYCGYGTVLMAAALPGGAHLCTVEPNPQHAAVAEKVIRLAGFDEQTVELIVGPTDEVIPQLKAQNGFDFVFMDHWKRSYLRDLRLLEEHGLLADKATVLADNVVFPGAPHFLQYAKTCGKYRCRVHRASLEYCRAIPDGIAELCYVGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y856</accession>
    <name>A0A8C2Y856_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of very long chain fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Very-long-chain 3-oxoacyl-CoA synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ELOVL6</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.199" evidence="10"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y856"/>
    <dbReference type="Ensembl" id="ENSCJPT00005011565.1">
        <property type="protein sequence ID" value="ENSCJPP00005007462.1"/>
        <property type="gene ID" value="ENSCJPG00005006876.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01050000244965"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009923">
        <property type="term" value="C:fatty acid elongase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042759">
        <property type="term" value="P:long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120162">
        <property type="term" value="P:positive regulation of cold-induced thermogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030457">
        <property type="entry name" value="ELO_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF125">
        <property type="entry name" value="ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01188">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="268"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005007462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="338" mass="39209" checksum="7F6C20B16B660ED5" modified="2022-01-19" version="1">MGFCMRSRCRSRHSYGLKWKPLSRMVDNSCCESYGHWSSFPLVLHLQNCRGINVYFAALHCLHGERKNTVLEASKQQSSALCSQAHHGEDSLETRCQALTCRRKKSFLFSALYAAFIFGGRHLMNKRAKFELRKPLVLWSLSLAVFSIFGAVRTAPYMLYILMTKGLKQSVCDQSFYIGPVSKFWAYAFVLSKAPELGDTIFIILRKQKLIFLHWYHHITVLLYSWYSYKDMVAGGGWFMTMNYGVHAVMYSYYALRAAGFRVSRKFAMFITLSQITQMLVGCVINYLVFSWMQHGQCHSHVQNIIWSSLMYLSYFVLFCHFFFEAYIGKTTKAKKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y8S9</accession>
    <name>A0A8C2Y8S9_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Family with sequence similarity 219 member B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FAM219B</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM219 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y8S9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005012799.1">
        <property type="protein sequence ID" value="ENSCJPP00005008448.1"/>
        <property type="gene ID" value="ENSCJPG00005007535.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000000860"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029339">
        <property type="entry name" value="FAM219"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31281">
        <property type="entry name" value="PROTEIN FAM219A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31281:SF2">
        <property type="entry name" value="PROTEIN FAM219B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15260">
        <property type="entry name" value="FAM219A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005008448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="208" mass="22571" checksum="60D1C8D13D94A176" modified="2022-01-19" version="1">MGIYGGIWGDMGLYGVIWGYMGLYGDIWGYMGLYGVIWGYMGPYRAHCAAFPPQLPRSDRRPGQRGGGATRSGPYTLSRAPAALQRQRELARAALRRHGLLGGPGRPPLKPTAKRAVKFHKGYVALSQTAEESLVSLDSDSDGELESRGSSGYSSAEQVNQDLSRQLLQDGYHLDEVPDDEDLDLIPPKPTTSSCPCCFGDSLSCVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YAN7</accession>
    <name>A0A8C2YAN7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Exostosin-2</fullName>
            <ecNumber evidence="5">2.4.1.224</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="primary">EXT2</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="27" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="27" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="20">Glycosyltransferase forming with EXT1 the heterodimeric heparan sulfate polymerase which catalyzes the elongation of the heparan sulfate glycan backbone. Glycan backbone extension consists in the alternating transfer of (1-&gt;4)-beta-D-GlcA and (1-&gt;4)-alpha-D-GlcNAc residues from their respective UDP-sugar donors. Both EXT1 and EXT2 are required for the full activity of the polymerase since EXT1 bears the N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity within the complex while EXT2 carries the glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity. Heparan sulfate proteoglycans are ubiquitous components of the extracellular matrix and play an important role in tissue homeostasis and signaling.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>3-O-{[(1-&gt;4)-beta-D-GlcA-(1-&gt;4)-alpha-D-GlcNAc](n)-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl}-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-{alpha-D-GlcNAc-[(1-&gt;4)-beta-D-GlcA-(1-&gt;4)-alpha-D-GlcNAc](n)-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl}-L-seryl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16213"/>
            <dbReference type="Rhea" id="RHEA-COMP:12621"/>
            <dbReference type="Rhea" id="RHEA-COMP:12623"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132415"/>
            <dbReference type="ChEBI" id="CHEBI:132416"/>
            <dbReference type="EC" id="2.4.1.224"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:16214"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="21">Part of the heparan sulfate polymerase, a dimeric complex composed of EXT1 and EXT2. Could also form homooligomeric complexes. Interacts with NDST1. Interacts with GALNT5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Golgi apparatus</location>
            <location evidence="18">cis-Golgi network membrane</location>
            <topology evidence="18">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 47 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.224" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2YAN7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005018390.1">
        <property type="protein sequence ID" value="ENSCJPP00005012722.1"/>
        <property type="gene ID" value="ENSCJPG00005010822.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156620"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043541">
        <property type="term" value="C:UDP-N-acetylglucosamine transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050508">
        <property type="term" value="F:glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050509">
        <property type="term" value="F:N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044344">
        <property type="term" value="P:cellular response to fibroblast growth factor stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002062">
        <property type="term" value="P:chondrocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060350">
        <property type="term" value="P:endochondral bone morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042044">
        <property type="term" value="P:fluid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006024">
        <property type="term" value="P:glycosaminoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060047">
        <property type="term" value="P:heart contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015012">
        <property type="term" value="P:heparan sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030210">
        <property type="term" value="P:heparin proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001707">
        <property type="term" value="P:mesoderm formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050891">
        <property type="term" value="P:multicellular organismal-level water homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001503">
        <property type="term" value="P:ossification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008217">
        <property type="term" value="P:regulation of blood pressure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055078">
        <property type="term" value="P:sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051923">
        <property type="term" value="P:sulfation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042311">
        <property type="term" value="P:vasodilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000035">
        <property type="entry name" value="Putative Exostosin-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004263">
        <property type="entry name" value="Exostosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040911">
        <property type="entry name" value="Exostosin_GT47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015338">
        <property type="entry name" value="GT64_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48261">
        <property type="entry name" value="ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48261:SF5">
        <property type="entry name" value="EXOSTOSIN GLYCOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03016">
        <property type="entry name" value="Exostosin_GT47"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09258">
        <property type="entry name" value="Glyco_transf_64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="17" id="KW-0464">Manganese</keyword>
    <keyword evidence="14 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 24" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="Exostosin GT47" evidence="25">
        <location>
            <begin position="101"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Exostosin GT47" evidence="25">
        <location>
            <begin position="236"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase 64" evidence="26">
        <location>
            <begin position="512"/>
            <end position="757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00033739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00050426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00053270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00064285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00069568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00083239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF03016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF09258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005012722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="774" mass="88804" checksum="F888750355126214" modified="2022-01-19" version="1">MCASAKYNTRGPALIPRMKTKHRIYYITLFSIVLLGLIATGVFQFWPHSIESSSDWTVEKRSVHDVPVVKLPADSPIPERGDLSCRMHTCFDVYRCGFNPKNKIKVYIYSLKKYVDEYGTSVSNTISREYNELLTAISDSEYYTDDVNRACLFVPSIDVLNQNTLRIKETAQALAQLSRYLLKPPHRTLQNSSGIKLCWRGGCSESVLELVLDRPYHLFIENIFIMVVSFFFCFRWDRGTNHLLFNMLPGGPPDYNTALDVPRDRALLAGGGFSTWTYRQGYDVSIPVYSPLSAEVDLPERGPGPRRYFILSSQMSLHPEYQSELEALQAENGESVLLLDKCTNLSDGVPAVRKRCHNNQIFDYPQVLQEATFCVVLRGARLGQAVLSDVLQAGCVPVIIADSYILPFSEVLDWKRASVVIPEEKMPEMYSILQSVPQRQIEEMQRQARWFWEAYFRSMKAIALATLQIINDRIYPYAAISYEEWNDPPAVKWSSVSNPLFLPLIPPQSQGFTAIVLTYDRVESLFRVITEVSKVPSLSKLLVVWNNQNKNPPEDSLWPKIRVPLKVVRTAENKLSNRFFPYDEIETEAVLAIDDDIIMLTSDELQFGYEVWREFPDRLVGYPGRLHLWDHEMNKWKYESEWTNEVSMVLTGAAFYHKYFNYLYTYKMPGDIKNWVDAHMNCEDIAMNFLVANVTGKSVIKVTPRKKFKCPECTAIDGLSLDQTHMVERSECINKFASVFGTMPLKVVEHRADPVLYKDDFPEKLKSFPNIGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YAR5</accession>
    <name>A0A8C2YAR5_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">40S ribosomal protein S15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">RPS15</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the small ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015741871.1">
        <property type="nucleotide sequence ID" value="XM_015886385.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YAR5"/>
    <dbReference type="SMR" id="A0A8C2YAR5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005018200.1">
        <property type="protein sequence ID" value="ENSCJPP00005012578.1"/>
        <property type="gene ID" value="ENSCJPG00005010695.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107325481"/>
    <dbReference type="KEGG" id="cjo:107325481"/>
    <dbReference type="CTD" id="6209"/>
    <dbReference type="GeneTree" id="ENSGT00390000000475"/>
    <dbReference type="OrthoDB" id="10258210at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097371">
        <property type="term" value="F:MDM2/MDM4 family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990948">
        <property type="term" value="F:ubiquitin ligase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901798">
        <property type="term" value="P:positive regulation of signal transduction by p53 class mediator"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.860.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="entry name" value="30s Ribosomal Protein S19, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_uS19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_uS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020934">
        <property type="entry name" value="Ribosomal_uS19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005713">
        <property type="entry name" value="Ribosomal_uS19_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_uS19_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003121">
        <property type="entry name" value="PRK04038.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01025">
        <property type="entry name" value="uS19_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="RIBOSOMAL PROTEIN S19P FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002144">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="Ribosomal protein S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00323">
        <property type="entry name" value="RIBOSOMAL_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00045746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005012578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="145" mass="17040" checksum="CA2C682302C7B387" modified="2022-01-19" version="1">MAEVEQKKKRTFRKFTYRGVDLDQLLDMSYEQLMQLYSARQRRRLNRGLRRKQHSLLKRLRKAKKEAPPMEKPEVVKTHLRDMIILPEMVGSMVGVYNGKTFNQVEIKPEMIGHYLGEFSITYKPVKHGRPGIGATHSSRFIPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YAW5</accession>
    <name>A0A8C2YAW5_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">5-taurinomethyluridine-[tRNA] synthase subunit GTPB3, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">GTP-binding protein 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">tRNA modification GTPase GTPBP3, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">GTPBP3</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">GTPase component of the GTPBP3-MTO1 complex that catalyzes the 5-taurinomethyluridine (taum(5)U) modification at the 34th wobble position (U34) of mitochondrial tRNAs (mt-tRNAs), which plays a role in mt-tRNA decoding and mitochondrial translation. Taum(5)U formation on mammalian mt-tRNA requires the presence of both GTPBP3-mediated GTPase activity and MTO1 catalytic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2YAW5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005019018.1">
        <property type="protein sequence ID" value="ENSCJPP00005013191.1"/>
        <property type="gene ID" value="ENSCJPG00005011151.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000016851"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160236">
        <property type="term" value="F:tRNA 5-taurinomethyluridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070899">
        <property type="term" value="P:mitochondrial tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04164">
        <property type="entry name" value="trmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14858">
        <property type="entry name" value="TrmE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.120:FF:000007">
        <property type="entry name" value="tRNA modification GTPase GTPBP3, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000924">
        <property type="entry name" value="tRNA modification GTPase GTPBP3, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.430">
        <property type="entry name" value="tRNA modification GTPase MnmE domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00379">
        <property type="entry name" value="GTPase_MnmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031168">
        <property type="entry name" value="G_TrmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018948">
        <property type="entry name" value="GTP-bd_TrmE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004520">
        <property type="entry name" value="GTPase_MnmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027368">
        <property type="entry name" value="MnmE_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025867">
        <property type="entry name" value="MnmE_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00450">
        <property type="entry name" value="mnmE_trmE_thdF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003661">
        <property type="entry name" value="PRK05291.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42714">
        <property type="entry name" value="TRNA MODIFICATION GTPASE GTPBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42714:SF2">
        <property type="entry name" value="TRNA MODIFICATION GTPASE GTPBP3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12631">
        <property type="entry name" value="MnmE_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10396">
        <property type="entry name" value="TrmE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116878">
        <property type="entry name" value="TrmE connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51709">
        <property type="entry name" value="G_TRME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 15" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TrmE-type G" evidence="16">
        <location>
            <begin position="265"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00059757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00069806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00077869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00081428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005013191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="507" mass="53657" checksum="83CAECDF3980F54C" modified="2022-01-19" version="1">MGLGGGHKLMGWGRVFLGGGVVALPYAFMGCCVPPPPLTRCTLCSVAPGDTIFAVSSGHGRCGVAVIRTSGPGSGGALLSLTGSTELPPPRLMTLRRIRDPHTAELLDRGLVVWFPGPQSFTGEDCAELHVHGGPAVLSGVLRALGRLSGLRPAEPGEFTRRAFHRGKLDLTAAEGLRDLIHAETEAQRQQALRQMEGELGRLYQRWGETLTQALAHIEAYIDFSEDDNVEEEVLSQVDEAVRALEQEIAAHLQDGRRGELLRSGVHAVIAGPPNVGKSSLLNMLCQRPAAIVSPIAGTTRDVVEVSLNVSGYPVVLSDTAGLRDATDPIEQEGVSRARDRLQHADLVLAVLDATTVPTDPAELGAALGSLVPPSTPCILVLNKADLLGGHKGALCDACTHGPPLPPTTLLSCKTGEGTDSLLQLLGQQLAQLCGDPLAGSPTLTQSRHSTQLHGCMAALVLYRQQQDVGMAAEQLRLARRHLGRITGHVGAEDILDVIFRDFCIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YBY0</accession>
    <name>A0A8C2YBY0_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YBY0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005021438.1">
        <property type="protein sequence ID" value="ENSCJPP00005015092.1"/>
        <property type="gene ID" value="ENSCJPG00005012542.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="114" mass="11798" checksum="5705CF79D54C7EF5" modified="2022-01-19" version="1">ARDLPRRDGPPPDQSGLGPAPATPPPAALQIVWRPSCCSLSGGCGRERAEEAGRTLNQDGVSQQAEDIRLSQRAMTPSDSAVPCVGPGTRVAVPRWESPCEGSSGTGSPQQRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YCQ4</accession>
    <name>A0A8C2YCQ4_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit epsilon</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit epsilon</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">EIF2B5</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2B gamma/epsilon subunits family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2YCQ4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005023468.1">
        <property type="protein sequence ID" value="ENSCJPP00005016750.1"/>
        <property type="gene ID" value="ENSCJPG00005013741.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00510000047568"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014002">
        <property type="term" value="P:astrocyte development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002183">
        <property type="term" value="P:cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042552">
        <property type="term" value="P:myelination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014003">
        <property type="term" value="P:oligodendrocyte development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001541">
        <property type="term" value="P:ovarian follicle development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050852">
        <property type="term" value="P:T cell receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd04197">
        <property type="entry name" value="eIF-2B_epsilon_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05787">
        <property type="entry name" value="LbH_eIF2B_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11558">
        <property type="entry name" value="W2_eIF2B_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.10.10:FF:000033">
        <property type="entry name" value="Eukaryotic translation initiation factor 2B subunit epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000022">
        <property type="entry name" value="Translation initiation factor eIF-2B epsilon subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000100">
        <property type="entry name" value="translation initiation factor eIF-2B subunit epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035543">
        <property type="entry name" value="eIF-2B_epsilon_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051956">
        <property type="entry name" value="eIF2B_epsilon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056764">
        <property type="entry name" value="LbH_EIF2B3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003307">
        <property type="entry name" value="W2_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044123">
        <property type="entry name" value="W2_eIF2B_epsilon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45887">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45887:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25084">
        <property type="entry name" value="LbH_EIF2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02020">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00515">
        <property type="entry name" value="eIF5C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51363">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="W2" evidence="10">
        <location>
            <begin position="472"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="382"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="426"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="386"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005016750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="652" mass="74558" checksum="966694C29B758C37" modified="2022-01-19" version="1">MANVAMIDYTLEFLTATGVEETFVFCCWKSAEIKEHLQKSKWCRHTSPNTVRFVTSDLYRSLGDVLRDVDAKSLVRSDFILVTGDVVSNLNISRALEEHKLRRKMEKNVSVMTMIFKESSPGHHARCKEDDIVIAMDSATNRVLHYQRTQGLKRFRFPMSLFQNSIENVEVRHDLLDCHISICSPQVAELFTDNFDYQTRDDFVRGLLVNEEILGNQIHMHVTTEEYGAHICNLLMYEAVCSDIIRRWVYPLTPEMNFTDDKNQNYTHSKHNIYRGEDVSLGHGSMLKENVLIGQGTVIGSNCSIMNSVIGQNCRIGDEVTLDGAFLWDGVHIADNVQIHHSVICDEAEVKEKVKLKPHCVLSSQVVVGPDITLSEGTVISLHPPDEEEEDDDQFSDDSGVNKEESKVKLKGYNKKDVGSEGRGYLWKADDKNEDDEEQRQSLWGPAMFSEEESESDSDLSMGSEEPDSRAASPQLDDIKVFQNEVLGTLQRGEEENISCDNLVLEINSLKYAYNISLNEMMQVLSKVILEFPLHQLDANLDSQKYFSALLPLLKNWTPLFKNYIKRSSDHLNALFAIEEFFLEHDSLCTSIAKVLMTFYQLEILEEDVILNWFSLRDTSDKGKQLRKNQRLQKFIQWLEEAEEESSDGDQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YDL4</accession>
    <name>A0A8C2YDL4_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cell adhesion molecule 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">CADM3</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2YDL4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005025909.1">
        <property type="protein sequence ID" value="ENSCJPP00005018646.1"/>
        <property type="gene ID" value="ENSCJPG00005015173.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159779"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000013">
        <property type="entry name" value="cell adhesion molecule 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003597">
        <property type="entry name" value="Ig_C1-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45889:SF5">
        <property type="entry name" value="CELL ADHESION MOLECULE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45889">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00407">
        <property type="entry name" value="IGc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="353"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="8"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="113"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="216"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="306"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="327"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005018646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="408" mass="44423" checksum="3AC39A8E70507D2D" modified="2022-01-19" version="1">MVPSLSSPFLHAVSQPTTSDETVVAGGTVVLKCQVEDPDDSSLQWSNPAQQTLYFGEKRALRDNRIQLVRSTPNELTISISDVVLSDEGEYTCSIFTMPVRTAKALVTVLGIPQKPQIFGHEQPIDEEKIARLTCRSSGSKPAAQLRWKKGNKELKAEGTEVVEDSNGKTFTVSSRVEFRVTKEDNDAEVTCTVDHESLQNSERSTTQKLQVHYKPTAKIEPHPQYPREGEKLQLQCDGQGNPVPQEFLWEKEGSDAPLQLSSDSILIFPFLNKSDSGTYICTATSSMGSVIAKYNLDVSDLSQLPTPHVHSTPAPLPGPSQPISHASMATASSSTPAPIQDASPVPSTSSTYHAVIGGVVAVIVFLLLSLLIVLGHYLIRHKGMCIRHGETTTARPQQNPPEVVMCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YDX9</accession>
    <name>A0A8C2YDX9_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NK2 homeobox 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">NKX2-2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YDX9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005026986.1">
        <property type="protein sequence ID" value="ENSCJPP00005019486.1"/>
        <property type="gene ID" value="ENSCJPG00005015788.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159727"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048708">
        <property type="term" value="P:astrocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048565">
        <property type="term" value="P:digestive tract development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045665">
        <property type="term" value="P:negative regulation of neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061101">
        <property type="term" value="P:neuroendocrine cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048665">
        <property type="term" value="P:neuron fate specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014003">
        <property type="term" value="P:oligodendrocyte development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003326">
        <property type="term" value="P:pancreatic A cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003329">
        <property type="term" value="P:pancreatic PP cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030858">
        <property type="term" value="P:positive regulation of epithelial cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045666">
        <property type="term" value="P:positive regulation of neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048714">
        <property type="term" value="P:positive regulation of oligodendrocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007224">
        <property type="term" value="P:smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021522">
        <property type="term" value="P:spinal cord motor neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021530">
        <property type="term" value="P:spinal cord oligodendrocyte cell fate specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003323">
        <property type="term" value="P:type B pancreatic cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003327">
        <property type="term" value="P:type B pancreatic cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060580">
        <property type="term" value="P:ventral spinal cord interneuron fate determination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005019486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="217" mass="22566" checksum="AF023448635AC9E2" modified="2022-01-19" version="1">MLLTNTKTGFSVKDILDLPDTNDEDGSAAEGGEEESEAAGPGRGAGSKSPEPSADESPDNEKEAAGGGDAGKKRKRRAGARFPAAAVPVSPEAGAPGQPDRLTPTQERYGSDSSPLPAAGGRAGPGAGRQSPATRSKLRTWRPPPSRRGTPASLSAYSAQSLQHMQYNAQYSAAGSPQYPTAHHLVQAQQWTLVTRAVSGGTHPAPHAPTQQERRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YFT6</accession>
    <name>A0A8C2YFT6_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dihydropyrimidinase-related protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Collapsin response mediator protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Inactive dihydropyrimidinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">CRMP1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance. During the axon guidance process, acts downstream of SEMA3A to promote FLNA dissociation from F-actin which results in the rearrangement of the actin cytoskeleton and the collapse of the growth cone. Involved in invasive growth and cell migration. May participate in cytokinesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homotetramer, and heterotetramer with DPYSL2, DPYSL3, DPYSL4 or DPYSL5. Interacts with PLXNA1. Interacts with FLNA (via calponin-homology (CH) domain 1 and filamin repeat 24); the interaction alters FLNA ternary structure and thus promotes FLNA dissociation from F-actin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Perikaryon</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015718129.1">
        <property type="nucleotide sequence ID" value="XM_015862643.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YFT6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005031996.1">
        <property type="protein sequence ID" value="ENSCJPP00005023343.1"/>
        <property type="gene ID" value="ENSCJPG00005018531.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107313927"/>
    <dbReference type="KEGG" id="cjo:107313927"/>
    <dbReference type="CTD" id="1400"/>
    <dbReference type="GeneTree" id="ENSGT01030000234527"/>
    <dbReference type="OrthoDB" id="10258955at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030426">
        <property type="term" value="C:growth cone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043204">
        <property type="term" value="C:perikaryon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098794">
        <property type="term" value="C:postsynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031005">
        <property type="term" value="F:filamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016812">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051219">
        <property type="term" value="F:phosphoprotein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010977">
        <property type="term" value="P:negative regulation of neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0150052">
        <property type="term" value="P:regulation of postsynapse assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071526">
        <property type="term" value="P:semaphorin-plexin signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01314">
        <property type="entry name" value="D-HYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000217">
        <property type="entry name" value="Dihydropyrimidinase-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.40.10:FF:000021">
        <property type="entry name" value="Dihydropyrimidinase-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.40.10:FF:000022">
        <property type="entry name" value="Dihydropyrimidinase-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011778">
        <property type="entry name" value="Hydantoinase/dihydroPyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050378">
        <property type="entry name" value="Metallo-dep_Hydrolases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02033">
        <property type="entry name" value="D-hydantoinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11647:SF54">
        <property type="entry name" value="DIHYDROPYRIMIDINASE-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11647">
        <property type="entry name" value="HYDRANTOINASE/DIHYDROPYRIMIDINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0944">Nitration</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="15">
        <location>
            <begin position="175"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="56"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="621"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="78"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="627"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="645"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00059281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00079257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00081558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005023343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="683" mass="74577" checksum="934DA754237DCE37" modified="2022-01-19" version="1">MAERKRNWNKEDDLPVYLARPGTTAQTPRQKYGGMFASVEGAYENKTIDFDAYSVGKKGSRTPRSGSRHDMLDGGDNYSETASDISEVSGSVISSPGEREDKTPGVEIRFPLGKELLQGPENGQSDRLLIKGGRIINDDQSFYADLYLEDGLIKQIGENLIVPGGVKTIEANGRMVIPGGIDVNTYLQKPYQGMTTVDDFYQGTKAAVAGGTTMIIDHVLPEPGTSLLTSFEKWHEAADTKSCCDYSLHVDITSWYDGIREELEVLVQDKGVNSFQVYMAYKDLYQMSDSQLYEAFTFLKSLGAVILVHAENGDLIAQEQKRILEMGITGPEGHALSRPEELEAEAVFRAITIASRINCPVYITKVMSKSAADIIALARKRGPLVFGEPITASLGTDGTHYWSKNWAKAAAFVTSPPLSPDPTTPDHLNSLLACGDLQVTGSGHCPYSTAQKAIGKDNFTMIPEGVNGIEERMTVVWDKAVATGKMDENQFVAVTSTNAAKIFNLYPRKGRIAVGSDADVVIWDPDKVKTITAKSHKSAVEYNIFEGMECHGAPLVVISQGKIVYEDGNLHVNKGMGRFIPRKPFPEYLYQRIKIRNKVGGLQGVSRGMYDGPVYEIPATPKYATPAPSTKSSPAKNQPPPIRNLHQSNFSLSGAQIDDNNPRRTGHRIVAPPGGRSNITSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YGB7</accession>
    <name>A0A8C2YGB7_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SRA stem-loop interacting RNA binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">SLIRP</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YGB7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005033372.1">
        <property type="protein sequence ID" value="ENSCJPP00005024494.1"/>
        <property type="gene ID" value="ENSCJPG00005019293.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000008624"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001669">
        <property type="term" value="C:acrosomal vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036126">
        <property type="term" value="C:sperm flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030317">
        <property type="term" value="P:flagellated sperm motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097222">
        <property type="term" value="P:mitochondrial mRNA polyadenylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905638">
        <property type="term" value="P:negative regulation of mitochondrial mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007338">
        <property type="term" value="P:single fertilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007286">
        <property type="term" value="P:spermatid development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd12242">
        <property type="entry name" value="RRM_SLIRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:001226">
        <property type="entry name" value="SRA stem-loop interacting RNA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034152">
        <property type="entry name" value="SLIRP_RRM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11176">
        <property type="entry name" value="BOULE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11176:SF61">
        <property type="entry name" value="SRA STEM-LOOP INTERACTING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="17"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005024494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="113" mass="13108" checksum="8C1CD1F87AE46709" modified="2022-01-19" version="1">HKMAAARGAVRQGRRIFDIFVAEIPWTVSSKELKEYFSQFGSVQRCQLPFDKDTGFHKRYCWIKFSSPEEVQNVLQKDSHILEGTKVTLHFQKPFVLKKSHQLGQTSCFSSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YGS2</accession>
    <name>A0A8C2YGS2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RILP-like protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Rab-interacting lysosomal-like protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">RILPL1</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the RILPL family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015733301.1">
        <property type="nucleotide sequence ID" value="XM_015877815.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YGS2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005034524.1">
        <property type="protein sequence ID" value="ENSCJPP00005025371.1"/>
        <property type="gene ID" value="ENSCJPG00005019922.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107321174"/>
    <dbReference type="KEGG" id="cjo:107321174"/>
    <dbReference type="CTD" id="353116"/>
    <dbReference type="GeneTree" id="ENSGT00940000157897"/>
    <dbReference type="OrthoDB" id="10069524at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003382">
        <property type="term" value="P:epithelial cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:1903445">
        <property type="term" value="P:protein transport from ciliary membrane to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd14445">
        <property type="entry name" value="RILP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1770:FF:000002">
        <property type="entry name" value="RILP-like protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1770">
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR051241">
        <property type="entry name" value="DZIP_RILPL"/>
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        <property type="entry name" value="RH1"/>
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    <dbReference type="InterPro" id="IPR021563">
        <property type="entry name" value="RILP_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21502:SF6">
        <property type="entry name" value="RILP-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21502">
        <property type="entry name" value="ZINC FINGER PROTEIN DZIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09744">
        <property type="entry name" value="RH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11461">
        <property type="entry name" value="RILP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161256">
        <property type="entry name" value="RILP dimerisation region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51776">
        <property type="entry name" value="RH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51777">
        <property type="entry name" value="RH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RH1" evidence="15">
        <location>
            <begin position="9"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="RH2" evidence="16">
        <location>
            <begin position="289"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="324"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="379"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="256"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="391"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
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            <dbReference type="ARBA" id="ARBA00038318"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00040816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005025371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="401" mass="46972" checksum="33DC5E6A72F28D85" modified="2022-01-19" version="1">MDGGGGVGVVPPALEKNAAELTVMDVYDIASAVGQEFERVIDQHGCEAIARLMPKVVRVLEILEVLVSRNHINPEMEELRLELDRLRLERMDRIEKERKHQKELELVEDVWRGEAQDLLTQIAQLQEENKQLMTNLSHKDINFTEEEFQKHEGMSERERQVMKKLKEVVDKQRDEIRAKDRELGLKNEDVEALQQQQNRLMKINHDLRHRITVVEAQGKALIEQKVELEAYLQTKEQEMGTLRAELGKLREKLQGEDNQNGEEIQTEPNNDDCLSESEKMAMDLKDPNRPRFTLQELRDVLHERNELKSKVFLLQEELLYYKSEETEEETRPPQPAPIIQSKPSTQPESGIKRLFSFFSRDKKRMQASQRNVHFQDTFREWSNSNKDDTYTEQGQEALQHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YH02</accession>
    <name>A0A8C2YH02_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Homer protein homolog 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Cupidin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">HOMER2</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cell projection</location>
            <location evidence="4">Stereocilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Postsynaptic density</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the Homer family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2YH02"/>
    <dbReference type="Ensembl" id="ENSCJPT00005035129.1">
        <property type="protein sequence ID" value="ENSCJPP00005025874.1"/>
        <property type="gene ID" value="ENSCJPG00005020214.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157324"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045177">
        <property type="term" value="C:apical part of cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032426">
        <property type="term" value="C:stereocilium tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035256">
        <property type="term" value="F:G protein-coupled glutamate receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030160">
        <property type="term" value="F:synaptic receptor adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048148">
        <property type="term" value="P:behavioral response to cocaine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007216">
        <property type="term" value="P:G protein-coupled glutamate receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070885">
        <property type="term" value="P:negative regulation of calcineurin-NFAT signaling cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032703">
        <property type="term" value="P:negative regulation of interleukin-2 production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008277">
        <property type="term" value="P:regulation of G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007605">
        <property type="term" value="P:sensory perception of sound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01206">
        <property type="entry name" value="EVH1_Homer_Vesl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000014">
        <property type="entry name" value="Homer homolog 1 (Drosophila)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1700:FF:000004">
        <property type="entry name" value="Homer homolog 2 (Drosophila)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045027">
        <property type="entry name" value="Homer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044100">
        <property type="entry name" value="Homer_EVH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014930">
        <property type="entry name" value="Myotonic_dystrophy_kinase_coil"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000697">
        <property type="entry name" value="WH1/EVH1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10918">
        <property type="entry name" value="HOMER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08826">
        <property type="entry name" value="DMPK_coil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00568">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00461">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50229">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="11 18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1009">Hearing</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0770">Synapse</keyword>
    <feature type="domain" description="WH1" evidence="20">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="112"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="168"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00072750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00080623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005025874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="356" mass="40548" checksum="39257B0EBDADB6C2" modified="2022-01-19" version="1">MGKEEQPIFTTRAHVFQIDPSTKKNWVPASKQAVTVSYFYDSTRNSYRIISVDGAKVIINSTITPNMTFTKTSQKFGQWADSRANTVFGLGFPSEQQLSKFAEKFQEVKEAAKLARDRSQEKIETSSNHSQESGRETPSSTRASSVNGTDDEKASHGGSAEAQLKSENDKLKIALAQSSSNVKKWETELQTLRESNARLTTALQESAASIEHWKKQFSACKEENDQLRSKIEELEEQCNEINKEKERNAQLSRRLQELETELQDKELELEELRKQGEIIPQLMSECESVSQQLQDAENKNKDLEEKVRTLRTEVEESKHRQTNLKTELKNFLDVLDGKIDELHDFRQGLSKLGVDN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1994-02-01" modified="2026-01-28" version="124" xmlns="https://uniprot.org/uniprot">
    <accession>P35075</accession>
    <accession>Q8SEW3</accession>
    <accession>Q9T888</accession>
    <name>CYB_COTJA</name>
    <protein>
        <recommendedName>
            <fullName>Cytochrome b</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Complex III subunit 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Complex III subunit III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Cytochrome b-c1 complex subunit 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Ubiquinol-cytochrome-c reductase complex cytochrome b subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">MT-CYB</name>
        <name type="synonym">COB</name>
        <name type="synonym">CYTB</name>
        <name type="synonym">MTCYB</name>
    </gene>
    <organism>
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <geneLocation type="mitochondrion"/>
    <reference key="1">
        <citation type="journal article" date="1993" name="J. Mol. Evol." volume="37" first="367" last="379">
            <title>Pathways of lysozyme evolution inferred from the sequences of cytochrome b in birds.</title>
            <authorList>
                <person name="Kornegay J.R."/>
                <person name="Kocher T.D."/>
                <person name="Williams L.A."/>
                <person name="Wilson A.C."/>
            </authorList>
            <dbReference type="PubMed" id="8308906"/>
            <dbReference type="DOI" id="10.1007/BF00178867"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2001" name="Anim. Genet." volume="32" first="380" last="385">
            <title>Complete sequence of the Japanese quail (Coturnix japonica) mitochondrial genome and its genetic relationship with related species.</title>
            <authorList>
                <person name="Nishibori M."/>
                <person name="Hayashi T."/>
                <person name="Tsudzuki M."/>
                <person name="Yamamoto Y."/>
                <person name="Yasue H."/>
            </authorList>
            <dbReference type="PubMed" id="11736810"/>
            <dbReference type="DOI" id="10.1046/j.1365-2052.2001.00795.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <tissue>Blood</tissue>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="1999-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete mitochondrial cytochrome b gene sequence in the wild type strain of Japanese quail (Coturnix japonica).</title>
            <authorList>
                <person name="Shen X.J."/>
                <person name="Nakamura T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="4">
        <citation type="submission" date="1998-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete mitochondrial cytochrome b gene sequence in Estonian strain of quail (Coturnix japonica).</title>
            <authorList>
                <person name="Shen X.J."/>
                <person name="Nakamura T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>Isolate Estonia</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="submission" date="1998-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete mitochondrial cytochrome b gene sequence in French strain of quail (Coturnix japonica).</title>
            <authorList>
                <person name="Shen X.J."/>
                <person name="Nakamura T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>Isolate French</strain>
        </source>
    </reference>
    <reference key="6">
        <citation type="submission" date="1999-01" db="EMBL/GenBank/DDBJ databases">
            <title>Complete mitochondrial cytochrome b gene sequence in Canadian strain of quail (Coturnix japonica).</title>
            <authorList>
                <person name="Shen X.J."/>
                <person name="Nakamura T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>Isolate Canadian</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="2">Binds 2 heme b groups non-covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">The cytochrome bc1 complex contains 11 subunits: 3 respiratory subunits (MT-CYB, CYC1 and UQCRFS1), 2 core proteins (UQCRC1 and UQCRC2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of UQCRFS1). This cytochrome bc1 complex then forms a dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">Heme 1 (or BL or b562) is low-potential and absorbs at about 562 nm, and heme 2 (or BH or b566) is high-potential and absorbs at about 566 nm.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the cytochrome b family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The full-length protein contains only eight transmembrane helices, not nine as predicted by bioinformatics tools.</text>
    </comment>
    <dbReference type="EMBL" id="L08377">
        <property type="protein sequence ID" value="AAA18851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AP003195">
        <property type="protein sequence ID" value="BAB62926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AF149292">
        <property type="protein sequence ID" value="AAD41344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AF112363">
        <property type="protein sequence ID" value="AAF21953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AF112364">
        <property type="protein sequence ID" value="AAF21954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AF119094">
        <property type="protein sequence ID" value="AAF28846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_572025.1">
        <property type="nucleotide sequence ID" value="NC_003408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P35075"/>
    <dbReference type="SMR" id="P35075"/>
    <dbReference type="GeneID" id="804660"/>
    <dbReference type="KEGG" id="cjo:804660"/>
    <dbReference type="CTD" id="4519"/>
    <dbReference type="OrthoDB" id="244at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:quinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00290">
        <property type="entry name" value="cytochrome_b_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00284">
        <property type="entry name" value="Cytochrome_b_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.810.10:FF:000002">
        <property type="entry name" value="Cytochrome b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.810.10">
        <property type="entry name" value="Cytochrome Bc1 Complex, Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005798">
        <property type="entry name" value="Cyt_b/b6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036150">
        <property type="entry name" value="Cyt_b/b6_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005797">
        <property type="entry name" value="Cyt_b/b6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027387">
        <property type="entry name" value="Cytb/b6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030689">
        <property type="entry name" value="Cytochrome_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048260">
        <property type="entry name" value="Cytochrome_b_C_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048259">
        <property type="entry name" value="Cytochrome_b_N_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016174">
        <property type="entry name" value="Di-haem_cyt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19271">
        <property type="entry name" value="CYTOCHROME B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19271:SF16">
        <property type="entry name" value="CYTOCHROME B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00032">
        <property type="entry name" value="Cytochrom_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00033">
        <property type="entry name" value="Cytochrome_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038885">
        <property type="entry name" value="COB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81648">
        <property type="entry name" value="a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81342">
        <property type="entry name" value="Transmembrane di-heme cytochromes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51003">
        <property type="entry name" value="CYTB_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51002">
        <property type="entry name" value="CYTB_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0249">Electron transport</keyword>
    <keyword id="KW-0349">Heme</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0679">Respiratory chain</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0830">Ubiquinone</keyword>
    <feature type="chain" id="PRO_0000060814" description="Cytochrome b">
        <location>
            <begin position="1"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="2">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <label>b562</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="2">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <label>b566</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="2">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <label>b562</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="2">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <label>b566</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>a ubiquinone</name>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
        </ligand>
    </feature>
    <feature type="sequence variant" description="In strain: Isolate French.">
        <original>S</original>
        <variation>F</variation>
        <location>
            <position position="29"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In strain: Isolate French.">
        <original>A</original>
        <variation>G</variation>
        <location>
            <position position="39"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In strain: Isolate French.">
        <original>S</original>
        <variation>C</variation>
        <location>
            <position position="247"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In strain: Isolate French.">
        <original>P</original>
        <variation>A</variation>
        <location>
            <position position="267"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 2; BAB62926." evidence="5" ref="2">
        <original>P</original>
        <variation>S</variation>
        <location>
            <position position="286"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 2; BAB62926." evidence="5" ref="2">
        <original>H</original>
        <variation>P</variation>
        <location>
            <position position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P00157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="380" mass="42666" checksum="89E725529FCF4DA0" modified="1994-02-01" version="1">MAPNIRKSHPLLKMINNSLIDLPTPPNISAWWNFGSLLAMCLITQILTGLLLAMHYTADTSLAFSSVAHTCRNVQYGWLIRNLHANGASFFFICIFLHIGRGLYYGSYLYKETWNTGVILLLTLMATAFVGYVLPWGQMSFWGATVITNLFSAVPYIGQTLVEWAWGGFSVDNPTLTRFFALHFLLPFLIAGITIIHLTFLHESGSNNPLGISSDSDKIPFHPYYSIKDILGLTLMLTPFLTLALFSPNFLGDPENFTPANPLVTPPHIKPEWYFLFAYAILRSIPNKLGGVLALAASVLILLLIPFLHKSKQRTMTFRPLSQTLFWLLVANLLILTWIGSQPVEHPFIIIGQMASLSYFTILLILFPMIGMLENKMLNH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1996-02-01" modified="2025-04-09" version="136" xmlns="https://uniprot.org/uniprot">
    <accession>P49701</accession>
    <name>VDR_COTJA</name>
    <protein>
        <recommendedName>
            <fullName>Vitamin D3 receptor</fullName>
            <shortName>VDR</shortName>
        </recommendedName>
        <alternativeName>
            <fullName>1,25-dihydroxyvitamin D3 receptor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Nuclear receptor subfamily 1 group I member 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">VDR</name>
        <name type="synonym">NR1I1</name>
    </gene>
    <organism>
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1994" name="Proc. Natl. Acad. Sci. U.S.A." volume="91" first="11596" last="11600">
            <title>The avian vitamin D receptors: primary structures and their origins.</title>
            <authorList>
                <person name="Elaroussi M.A."/>
                <person name="Prahl J.M."/>
                <person name="DeLuca H.F."/>
            </authorList>
            <dbReference type="PubMed" id="7972109"/>
            <dbReference type="DOI" id="10.1073/pnas.91.24.11596"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B)</scope>
        <source>
            <tissue>Chorioallantoic membrane</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells. Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR. The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes (By similarity). Plays a central role in calcium homeostasis (By similarity). Also functions as a receptor for the secondary bile acid lithocholic acid (LCA) and its metabolites.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer in the absence of bound vitamin D3. Heterodimer with RXRA after vitamin D3 binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="1">Localizes mainly to the nucleus. Translocated into the nucleus via both ligand-dependent and ligand-independent pathways; ligand-independent nuclear translocation is mediated by IPO4.</text>
    </comment>
    <comment type="alternative products">
        <event type="alternative initiation"/>
        <isoform>
            <id>P49701-1</id>
            <name>A</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>P49701-2</id>
            <name>B</name>
            <sequence type="described" ref="VSP_018772"/>
        </isoform>
    </comment>
    <comment type="domain">
        <text evidence="1">Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the nuclear hormone receptor family. NR1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="U12641">
        <property type="protein sequence ID" value="AAA56725.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="PIR" id="I50451">
        <property type="entry name" value="I50451"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001310170.1">
        <molecule id="P49701-1"/>
        <property type="nucleotide sequence ID" value="NM_001323241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P49701"/>
    <dbReference type="SMR" id="P49701"/>
    <dbReference type="GeneID" id="107306955"/>
    <dbReference type="KEGG" id="cjo:107306955"/>
    <dbReference type="CTD" id="7421"/>
    <dbReference type="OrthoDB" id="6352325at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004879">
        <property type="term" value="F:nuclear receptor activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070644">
        <property type="term" value="F:vitamin D response element binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070561">
        <property type="term" value="P:vitamin D receptor signaling pathway"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="CDD" id="cd06955">
        <property type="entry name" value="NR_DBD_VDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06933">
        <property type="entry name" value="NR_LBD_VDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000023">
        <property type="entry name" value="Vitamin D3 receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.565.10:FF:000021">
        <property type="entry name" value="Vitamin D3 receptor B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042153">
        <property type="entry name" value="DBD_VDR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050234">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000324">
        <property type="entry name" value="VitD_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082:SF38">
        <property type="entry name" value="VITAMIN D3 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00350">
        <property type="entry name" value="VITAMINDR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0024">Alternative initiation</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0675">Receptor</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_0000019935" description="Vitamin D3 receptor">
        <location>
            <begin position="1"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="4">
        <location>
            <begin position="147"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Nuclear receptor" evidence="3">
        <location>
            <begin position="41"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="NR C4-type" evidence="3">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="NR C4-type" evidence="3">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Hinge" evidence="1">
        <location>
            <begin position="117"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with coactivator LXXLL motif" evidence="2">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="9aaTAD" evidence="1">
        <location>
            <begin position="437"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>calcitriol</name>
            <dbReference type="ChEBI" id="CHEBI:17823"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>calcitriol</name>
            <dbReference type="ChEBI" id="CHEBI:17823"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>calcitriol</name>
            <dbReference type="ChEBI" id="CHEBI:17823"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>calcitriol</name>
            <dbReference type="ChEBI" id="CHEBI:17823"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="418"/>
        </location>
        <ligand>
            <name>calcitriol</name>
            <dbReference type="ChEBI" id="CHEBI:17823"/>
        </ligand>
    </feature>
    <feature type="splice variant" id="VSP_018772" description="In isoform B." evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P11473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P13053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="5">
        <source>
            <dbReference type="PubMed" id="7972109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <sequence length="448" mass="50668" checksum="FCF1FC3DEAEEAF3E" modified="1996-02-01" version="1">MVSISASGGYAMPCCCESQELQSSDMETPAVGTPEFDRNVPRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKAMFTCPFSGDCKITKDNRRHCQACRLKRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKESLKPKLSEEQQKVINILLEAHHKTFDTTYSDFNKFRPPVRSKFSSSTATHSSSVVSQDFSSEDSNDVFGSDAFGAFPEPMEPQMFSNLDLSEESDESPSMNIELPHLPMLPHLADLVSYSIQKVIGFAKMIPGFRDLTAEDQIALLKSSAIEVIMLRSNQSFTMEDMSWTCGSNDFKYKVSDVTQAGHSMDLLEPLVKFQVGLKKLNLHEEEHVLLMAICILSPDRPGVQDTSLVESIQDRLSDTLQTYIRCRHPPPGSRLLYAKMIQKLADLRSLNEEHSKQYRCLSFQPEHSMQLTPLVLEVFGNEIS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1996-10-01" modified="2026-01-28" version="164" xmlns="https://uniprot.org/uniprot">
    <accession>P52583</accession>
    <name>VGFR2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Vascular endothelial growth factor receptor 2</fullName>
            <shortName>VEGFR-2</shortName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Endothelial kinase receptor EK1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Quek 1</fullName>
            <shortName>Quek1</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">KDR</name>
        <name type="synonym">EK1</name>
        <name type="synonym">FLK-1</name>
    </gene>
    <organism>
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1996" name="Gene" volume="174" first="3" last="8">
            <title>Molecular cloning of Quek 1 and 2, two quail vascular endothelial growth factor (VEGF) receptor-like molecules.</title>
            <authorList>
                <person name="Eichmann A"/>
                <person name="Marcelle C"/>
                <person name="Breant C"/>
                <person name="Le Douarin NMM"/>
            </authorList>
            <dbReference type="PubMed" id="8863722"/>
            <dbReference type="DOI" id="10.1016/0378-1119(96)00159-X"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA]</scope>
        <source>
            <tissue>Embryo</tissue>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1993" name="Mech. Dev." volume="42" first="33" last="48">
            <title>Two molecules related to the VEGF receptor are expressed in early endothelial cells during avian embryonic development.</title>
            <authorList>
                <person name="Eichmann A."/>
                <person name="Marcelle C."/>
                <person name="Breant C."/>
                <person name="Le Douarin N.M."/>
            </authorList>
            <dbReference type="PubMed" id="8396413"/>
            <dbReference type="DOI" id="10.1016/0925-4773(93)90096-G"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] OF 910-1348</scope>
        <source>
            <tissue>Spinal cord</tissue>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1995" name="Dev. Biol." volume="169" first="699" last="712">
            <title>Vascular endothelial growth factor (VEGF) and VEGF receptor 2 (flk-1) are expressed during vasculogenesis and vascular differentiation in the quail embryo.</title>
            <authorList>
                <person name="Flamme I."/>
                <person name="Breier G."/>
                <person name="Risau W."/>
            </authorList>
            <dbReference type="PubMed" id="7781909"/>
            <dbReference type="DOI" id="10.1006/dbio.1995.1180"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] OF 764-880</scope>
        <scope>CHARACTERIZATION</scope>
        <source>
            <tissue>Embryo</tissue>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="1992" name="Oncogene" volume="7" first="2479" last="2487">
            <title>Molecular cloning of a family of protein kinase genes expressed in the avian embryo.</title>
            <authorList>
                <person name="Marcelle C."/>
                <person name="Eichmann A."/>
            </authorList>
            <dbReference type="PubMed" id="1281306"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] OF 1023-1079</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and/or VEGFD and plays an essential role in the regulation of angiogenesis and vascular development. Promotes proliferation, survival, migration and differentiation of endothelial cells. Promotes reorganization of the actin cytoskeleton. Binding of vascular growth factors leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, reorganization of the actin cytoskeleton and activation of PTK2/FAK1. Required for VEGFA-mediated induction of NOS2 and NOS3, leading to the production of the signaling molecule nitric oxide (NO) by endothelial cells.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="1">Present in an inactive conformation in the absence of bound ligand. Binding of VEGFA, VEGFC or VEGFD leads to dimerization and activation by autophosphorylation on tyrosine residues.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Early endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <text evidence="1">Detected on caveolae-enriched lipid rafts at the cell surface. Is recycled from the plasma membrane to endosomes and back again. Phosphorylation triggered by VEGFA binding promotes internalization and subsequent degradation. Localized with RAP1A at cell-cell junctions (By similarity).</text>
    </comment>
    <comment type="tissue specificity">
        <text>In all endothelial tissues during onset of vascularization. In later development, present in lung, heart, intestine and skin.</text>
    </comment>
    <comment type="developmental stage">
        <text>Expressed in whole mesoderm at onset of gastrulation. From day 2, confined to endothelial tissues and expression continues to be widespread throughout vascularization until 9 dpc where it becomes restricted to specific regions such as the spinal cord and heart valves.</text>
    </comment>
    <comment type="induction">
        <text>In vitro, it is induced by basic fibroblast growth factor (bFGF), uniquely in the first 24 hours of cell culture.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The second and third Ig-like C2-type (immunoglobulin-like) domains are sufficient for VEGF binding.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">Autophosphorylated on tyrosine residues upon ligand binding. Autophosphorylation occurs in trans, i.e. one subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="EMBL" id="X83288">
        <property type="protein sequence ID" value="CAA58268.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="S65205">
        <property type="protein sequence ID" value="AAB28127.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="S78345">
        <property type="protein sequence ID" value="AAB34594.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="PIR" id="JC4953">
        <property type="entry name" value="S51656"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P52583"/>
    <dbReference type="BMRB" id="P52583"/>
    <dbReference type="SMR" id="P52583"/>
    <dbReference type="DIP" id="DIP-450N"/>
    <dbReference type="GlyCosmos" id="P52583">
        <property type="glycosylation" value="20 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="BRENDA" id="2.7.10.1">
        <property type="organism ID" value="1673"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070161">
        <property type="term" value="C:anchoring junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019838">
        <property type="term" value="F:growth factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005021">
        <property type="term" value="F:vascular endothelial growth factor receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001525">
        <property type="term" value="P:angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035924">
        <property type="term" value="P:cellular response to vascular endothelial growth factor stimulus"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045446">
        <property type="term" value="P:endothelial cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060562">
        <property type="term" value="P:epithelial tube morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045766">
        <property type="term" value="P:positive regulation of angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050679">
        <property type="term" value="P:positive regulation of epithelial cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001934">
        <property type="term" value="P:positive regulation of protein phosphorylation"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009967">
        <property type="term" value="P:positive regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046777">
        <property type="term" value="P:protein autophosphorylation"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001936">
        <property type="term" value="P:regulation of endothelial cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043408">
        <property type="term" value="P:regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048010">
        <property type="term" value="P:vascular endothelial growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05862">
        <property type="entry name" value="IgI_VEGFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05864">
        <property type="entry name" value="IgI_VEGFR-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05103">
        <property type="entry name" value="PTKc_VEGFR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000077">
        <property type="entry name" value="Vascular endothelial growth factor receptor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000532">
        <property type="entry name" value="Vascular endothelial growth factor receptor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000596">
        <property type="entry name" value="Vascular endothelial growth factor receptor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000669">
        <property type="entry name" value="Vascular endothelial growth factor receptor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000767">
        <property type="entry name" value="Vascular endothelial growth factor receptor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000041">
        <property type="entry name" value="Vascular endothelial growth factor receptor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000143">
        <property type="entry name" value="Vascular endothelial growth factor receptor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000247">
        <property type="entry name" value="Vascular endothelial growth factor receptor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013151">
        <property type="entry name" value="Immunoglobulin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001824">
        <property type="entry name" value="Tyr_kinase_rcpt_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041348">
        <property type="entry name" value="VEGFR-2_TMD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055229">
        <property type="entry name" value="VEGFR1-3_5th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055238">
        <property type="entry name" value="VEGFR1-3_N_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009136">
        <property type="entry name" value="VEGFR2_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF45">
        <property type="entry name" value="VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00047">
        <property type="entry name" value="ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22971">
        <property type="entry name" value="Ig_VEGFR-1-like_5th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21339">
        <property type="entry name" value="VEGFR-1-like_Ig-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17988">
        <property type="entry name" value="VEGFR-2_TMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22854">
        <property type="entry name" value="VEGFR1-3_N_Ig-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000615">
        <property type="entry name" value="TyrPK_CSF1-R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01832">
        <property type="entry name" value="VEGFRECEPTOR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01834">
        <property type="entry name" value="VEGFRECEPTR2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00240">
        <property type="entry name" value="RECEPTOR_TYR_KIN_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0037">Angiogenesis</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0965">Cell junction</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword id="KW-0217">Developmental protein</keyword>
    <keyword id="KW-0221">Differentiation</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0967">Endosome</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0393">Immunoglobulin domain</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-0675">Receptor</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000016774" description="Vascular endothelial growth factor receptor 2">
        <location>
            <begin position="21"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="topological domain" description="Extracellular" evidence="3">
        <location>
            <begin position="21"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="757"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="3">
        <location>
            <begin position="778"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like C2-type 1">
        <location>
            <begin position="43"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like C2-type 2">
        <location>
            <begin position="138"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like C2-type 3">
        <location>
            <begin position="220"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like C2-type 4">
        <location>
            <begin position="320"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like C2-type 5">
        <location>
            <begin position="412"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like C2-type 6">
        <location>
            <begin position="540"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like C2-type 7">
        <location>
            <begin position="658"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="825"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="958"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1280"/>
            <end position="1302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="958"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5 6">
        <location>
            <position position="1021"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="831"/>
            <end position="839"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="859"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Phosphotyrosine; by autocatalysis" evidence="1">
        <location>
            <position position="1047"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphotyrosine; by autocatalysis" evidence="1">
        <location>
            <position position="1052"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphotyrosine; by autocatalysis" evidence="1">
        <location>
            <position position="1168"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphotyrosine; by autocatalysis" evidence="1">
        <location>
            <position position="1207"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="365"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="386"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="513"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="556"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="603"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="613"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="622"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="666"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="688"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="710"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="50"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="145"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="241"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="436"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="561"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="679"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 3; AAB34594." evidence="8" ref="3">
        <original>A</original>
        <variation>S</variation>
        <location>
            <position position="865"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P35968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3"/>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="8"/>
    <sequence length="1348" mass="150306" checksum="A5E4194A76FD5FB3" modified="1996-10-01" version="1" precursor="true">MELGPLRVLTVLLCLAPVFAGLFISMDQPTLSIQKSVLTITTNDTLNITCSGQRAVYWSWPNNQSSVEKRLAVTGCSEGPFCKTLTLLRVIGNDTGDYRCLYGDSQAATTIYVYVQDYRSPFVTSVGDQLGIVYITKNKTVVVPCLGTVSNLNVSLHAKYPEKVFVPDGKSISWDNKKGFTIPSHLINYAGMVFCEAKIDNESYQSVIYIVAVVGYRIYDLTMNPHYQVELAVGEKLVLNCTVRTELNVGIDFRWDYPSIKERRATIRDLKTTAGEIKTFVSTLTIESVNLSDKGRYTCAASSGRMNMKNSSYFIIHESPFIHLEKMENVVEMKLGDTVSIPVKFKGYPPPEAKWYKNGKVINANHTVKLGYALVITEATEKDAGNYTVVLTNPTNKMQKRHTFTLLVNVPPQIGENALMAPVDSYKYGSTQALTCTIYAVPPPAAVLWYWQLEEECTFSPQKVRLGANPYACRKWKVISERKGGNQVEIKQRVVTIAGKTKTVSTLVIQAANVSALYRCMATNRAGSSERVISFHVTRGLEINLQPRSQLTEKDNTSLQCTADKFTFEKLSWYKLSTHVSQTPFGGLPMPVCKNLDALQKLNATVSNVNGENVTLELILRNISLQDGGDYVCIAQDKKAKTQHCLVKHLTVQEPLHPRLVGNLENQTTNIGETIEVLCTVNGVPPPNITWFKNSETLFEDSGIVLKDGNKTLTIRRVRKEDGGLYTCLACNILGCKKAEAFFSVQGAEEKTNLELIILVGTAVIAMFFWLLLVIILRTVKRANGGDMKTGYLSIIMDPDEVPIDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEYCKFGNLSAYLRSKRSEFIPYKMKSARFRQGKENYTGDISTDLKQRLDSITSSQSSTSSGFVEERSLSDVEEEDAGSEDLCKNPLTMEDLICYSFQVARGMEFLASRKCIHRDLAARNILLSDNNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGDPKQRPTFSELVEHLGNLLQANVRQDGKDYVVLPLSVSLNMEEDSGLSLPTSPASCKEEEEVCDPKFHYDNTAGISQYRQGSKRKSRPVSVKTFEDIPLVTTVKVVQEENQTDSGMVLASEELKTLEEQDKQVKIPFSTLAPSKSNESVMSEASNQTSGYQSGYHSDDMDNMVCSSEDTELLCAQEASPTLPRCAWPGIYSPAPVASLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SLU8</accession>
    <name>A0A8C2SLU8_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Galectin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC107313434</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015717136.1">
        <property type="nucleotide sequence ID" value="XM_015861650.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SLU8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005001301.1">
        <property type="protein sequence ID" value="ENSCJPP00005000739.1"/>
        <property type="gene ID" value="ENSCJPG00005000817.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107313434"/>
    <dbReference type="KEGG" id="cjo:107313434"/>
    <dbReference type="GeneTree" id="ENSGT00940000155534"/>
    <dbReference type="OrthoDB" id="8443340at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030395">
        <property type="term" value="F:lactose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043236">
        <property type="term" value="F:laminin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00070">
        <property type="entry name" value="GLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000021">
        <property type="entry name" value="Galectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044156">
        <property type="entry name" value="Galectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001079">
        <property type="entry name" value="Galectin_CRD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11346">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11346:SF97">
        <property type="entry name" value="GALECTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00337">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00908">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00276">
        <property type="entry name" value="GLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51304">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0430">Lectin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Galectin" evidence="3">
        <location>
            <begin position="4"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU102079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005000739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="134" mass="14986" checksum="5FE8D9C4A3DA6C55" modified="2022-01-19" version="1">MEQGLVVTQLDVQPGECVKVKGKIPSDAKGFSVNVGKDSSNLMLHFNPRFDCHGDVNTIVCNSKEDGMWGEEDRKADFPFQHGDKVEICISFDAAEVKVKVPDVEFEFPNRLGMEKIQYLSVEGDFKVKAIKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SMA1</accession>
    <name>A0A8C2SMA1_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BSD domain containing 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BSDC1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SMA1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005001563.1">
        <property type="protein sequence ID" value="ENSCJPP00005000880.1"/>
        <property type="gene ID" value="ENSCJPG00005000915.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000009361"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3970.10">
        <property type="entry name" value="BSD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005607">
        <property type="entry name" value="BSD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035925">
        <property type="entry name" value="BSD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051494">
        <property type="entry name" value="BSD_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16019:SF5">
        <property type="entry name" value="BSD DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16019">
        <property type="entry name" value="SYNAPSE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03909">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00751">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140383">
        <property type="entry name" value="BSD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50858">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BSD" evidence="2">
        <location>
            <begin position="175"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005000880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="480" mass="52359" checksum="1BFB73203A1630E3" modified="2022-01-19" version="1">APPRQAVPGGEGSVNIGDVTPPRWLTGECGVTAEDGGWWRSWLQQSYQAVKEKSTEALEFMKRDLAEFTQVVQHDTACTIAATASVVKDKLARTEASGATEKVRKGISDFLGVISDTFAPSPDKTIDCDVITLMATPTGTTEPYDSVKARLYSLQSDPATYCNEPDGPAELLEAWLSQFRLEEKKGEIAELLATSPSIRALYTKMVPAAVSHLEFWQRYFYKVHRLEQDEVRREALKQRAEQSIHQEEPGWEEDEEEFLGMSPLPCANVKFPQAAEKASAPAALEGSHPSVLKGPSEESWAILPPELAPAEGSPSESSESVSLVTQIANPATVPAVQLQTGAQPSGDRELSQRLLEATSEEQSQLPKPPEPGCPSVPAQEPAACSEQPAGTGPKEVESKAQGRTETLKEEGPTDLRIFELNSDSGKSTPSNNGKKGSSTDISEDWEKDFDLDMTEEEVQLALSKVEVSGELEDEEWEDWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SN09</accession>
    <name>A0A8C2SN09_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Polypyrimidine tract-binding protein 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Neural polypyrimidine tract-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">PTBP2</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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            <authorList>
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        <scope>IDENTIFICATION</scope>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SP36</accession>
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            <taxon>Archosauria</taxon>
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            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
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            <taxon>Aves</taxon>
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            <taxon>Galliformes</taxon>
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        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
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                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <text evidence="1">Belongs to the GSK-3-binding protein family.</text>
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            <begin position="39"/>
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    <feature type="compositionally biased region" description="Pro residues" evidence="2">
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            <begin position="70"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="173" mass="18299" checksum="FAC3CC86A8A2E917" modified="2022-01-19" version="1">MPCRPGERFLLLERSVSVGPAGSKEVDALVAKLGEVLQLSAQRAPPPRGPKYQPGPGSARDRAAPYSPRCCPPGPQPALPPALPPGATRPEQQRVAKQLCGRGWLRSAARRRKQQRRPPPGPPDPHEEDPHRLLQQLILSGNLIKEAVRRLQLAAAAVGSGGGDGEAAAAAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SP90</accession>
    <name>A0A8C2SP90_COTJA</name>
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        <submittedName>
            <fullName evidence="3">Microtubule associated protein 1A</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="primary">MAP1A</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:axonogenesis"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="MAP1"/>
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        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13843:SF6">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25281">
        <property type="entry name" value="MBL_MAP1B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
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            <begin position="335"/>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SQ88</accession>
    <name>A0A8C2SQ88_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Cystine/glutamate transporter</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Amino acid transport system xc-</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Solute carrier family 7 member 11</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">xCT</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">SLC7A11</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-cystine(out) + L-glutamate(in) = L-cystine(in) + L-glutamate(out)</text>
            <dbReference type="Rhea" id="RHEA:70995"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35491"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N-acetyl-L-cysteine(out) + L-glutamate(in) = N-acetyl-L-cysteine(in) + L-glutamate(out)</text>
            <dbReference type="Rhea" id="RHEA:74567"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:78236"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>an L-alpha-amino acid(in) + L-kynurenine(out) = an L-alpha-amino acid(out) + L-kynurenine(in)</text>
            <dbReference type="Rhea" id="RHEA:71191"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc; this interaction mediates cell membrane localization.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Microvillus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SQ88"/>
    <dbReference type="Ensembl" id="ENSCJPT00005001685.1">
        <property type="protein sequence ID" value="ENSCJPP00005000956.1"/>
        <property type="gene ID" value="ENSCJPG00005001052.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160324"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097449">
        <property type="term" value="C:astrocyte projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031526">
        <property type="term" value="C:brush border membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031528">
        <property type="term" value="C:microvillus membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015327">
        <property type="term" value="F:cystine:glutamate antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140926">
        <property type="term" value="F:L-kynurenine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022840">
        <property type="term" value="F:leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015252">
        <property type="term" value="F:proton channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030534">
        <property type="term" value="P:adult behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140206">
        <property type="term" value="P:dipeptide import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <sequence length="748" mass="73905" checksum="AA4CC39932539354" modified="2022-01-19" version="1">MLVHSYQLHVLVHSVPLHSFLSTLTTPFRFSTWYRCHSCLSLGPHHSFFVHSRYRSHVVSFSTRPLRSVSFPPGTAPFRCSCPLGTAPFGSFPLGTAPFGACPLGTAPFGASPLGTAPFGACPLGTAPFGSCPPSTAPFGACPLGTTPFGSSPLGTAPFGSCPLGTAPFGACPLGTAPFGASPLGTAPFGSCPLGTAPFGSCPPGTAPFGSCPPGTAPFGSCPPGTAPFGSCPLGTAPFGSCPLGTAPFGPCPLGTTPFGSCPPGTAPFGSCPLGTAPFGACPLGTAPFSSCPLGTAPFGSCPLGTAPFGSFPLGTAPFGSCPLGTAPFGSFPLGTAPFGSCPLGTAPFGSCPLGTASFGSCPLGTAPFGSCPLGTAPFGSCPLGTAPFGSCPLGTAPFGSCPLGTAPFGSCPLGTAPFGSCPLGTAPLGACPLGTAPFGSCPLSTAPFGSFPLSTAPFGSFPLGTVLFGSCPLGTALFGACATMLCAAPLGTAPFSSFPLSTAPFGSCPLSTAPFGSCPPSTAPFGSCPLGTAPFGACPLGTAPFGPCPPSTAPFGACPLGTAPFSTSPFGTAPFSACPLSTAPFGTVLFGSCPLGTALFGACATLLCAAPLSTAPFSSCPLGTAPPMAKLVLPPPPPPPSVLPLPLPLPPHAPLSTLLRPTTHSAIMYEPAPAASSLGVRPPLQPLTPLREATRHTHLIAMTLQLCGDPPTPLDFVASEPVKEISGHREEHRCAPEKQKSEHERER</sequence>
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        </source>
    </evidence>
    <sequence length="657" mass="68682" checksum="8FAD71ACBFA172FC" modified="2022-01-19" version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sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SR66</accession>
    <name>A0A8C2SR66_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thymidine phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TYMP</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SR66"/>
    <dbReference type="Ensembl" id="ENSCJPT00005003701.1">
        <property type="protein sequence ID" value="ENSCJPP00005002055.1"/>
        <property type="gene ID" value="ENSCJPG00005002228.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000009250"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004645">
        <property type="term" value="F:1,4-alpha-oligoglucan phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009032">
        <property type="term" value="F:thymidine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006206">
        <property type="term" value="P:pyrimidine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006213">
        <property type="term" value="P:pyrimidine nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905333">
        <property type="term" value="P:regulation of gastric motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031641">
        <property type="term" value="P:regulation of myelination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051969">
        <property type="term" value="P:regulation of transmission of nerve impulse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="entry name" value="Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.970.10">
        <property type="entry name" value="Transferase, Pyrimidine Nucleoside Phosphorylase, Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017459">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036320">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017872">
        <property type="entry name" value="Pyrmidine_PPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000053">
        <property type="entry name" value="Thymidine/pyrmidine_PPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004490">
        <property type="entry name" value="PRK05820.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10515">
        <property type="entry name" value="THYMIDINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10515:SF0">
        <property type="entry name" value="THYMIDINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02885">
        <property type="entry name" value="Glycos_trans_3N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47648">
        <property type="entry name" value="Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00647">
        <property type="entry name" value="THYMID_PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase family 3 N-terminal" evidence="5">
        <location>
            <begin position="35"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 3" evidence="4">
        <location>
            <begin position="107"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005002055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="456" mass="48437" checksum="8409E50F30B7DF2F" modified="2025-10-08" version="2">MSSAETPGPGQAGTAPGRDALRGRCGMERTEPVPELIRKKRDGERLRDNEIRSFVRAVTDGTAQQGQIGAMLMAVRLRGMDQHETLSLTRAMMESGRELEWPQEWNGVIVDKHSTGGVGDKVSIVLAPALAACGCKVPMISGRGLGHTGGTLDKLEAIPGFCVTQSPEQMRRIVGSVGCCIVGQSAELVPADRALYGLRDVTATIDSVPLITASILSKKAAERVTALLLDVKFGSAALCPDVDSATELARSLVRPPPSYHPLTTSPHSPPHAVSRCQSWCCLPVPYPCAGPGPGPGPVSWCRSRCQSRCQILALVPVPYPCAGPGAFSRYRSRCCIPMPCPGGVSLCRSRCRVPVPYPDAASRCQILVPVPVPDPGAISLCHVPVPCPGAGPCAVSLSRFRSRFGSDLSFPLPSGDPWLRLHHNGHVGAEQRRVLQSALLPPLIADIVLPHGAEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SRX7</accession>
    <name>A0A8C2SRX7_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Kaptin, actin binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">KPTN</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SRX7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005005286.1">
        <property type="protein sequence ID" value="ENSCJPP00005002890.1"/>
        <property type="gene ID" value="ENSCJPG00005003168.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000002548"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031941">
        <property type="term" value="C:filamentous actin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140007">
        <property type="term" value="C:KICSTOR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098871">
        <property type="term" value="C:postsynaptic actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042149">
        <property type="term" value="P:cellular response to glucose starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061462">
        <property type="term" value="P:protein localization to lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029982">
        <property type="entry name" value="Kptn"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15435">
        <property type="entry name" value="KICSTOR COMPLEX PROTEIN KAPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15435:SF2">
        <property type="entry name" value="KICSTOR COMPLEX PROTEIN KAPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005002890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="269" mass="28844" checksum="8C1174CAD054E9E9" modified="2022-01-19" version="1">MAAGPCPLVEDSCSRLPSQSNVFGLAALPGAGGLLAATLKGKVLHFRYQQLRHKLRPVATELQFTYIPVDAEIVSIGCFQKSAPKRGLVVGITFIKDSGDKPSPFLNIYCDYEPGCEFDLDSVAQSCLNLELRFTPLQLCHAEYVTPLSPIVSPLCPIVPHCVPLCPIVPPLCPIEPHCAPLSPIVPHCVSLCPIVPPLSPIVSHCVPIVSHCVPLCPHCVPLCPIVPHCVPLCPIVPHCCPCPPYVPMLCPPIAPIVSPPQGLHWGQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SSY7</accession>
    <name>A0A8C2SSY7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Presenilin</fullName>
            <ecNumber evidence="11">3.4.23.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">PSEN2</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins. The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is involved in calcium homeostasis. Is a regulator of mitochondrion-endoplasmic reticulum membrane tethering and modulates calcium ions shuttling between ER and mitochondria.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endoplasmic reticulum membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Golgi apparatus membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The PAL motif is required for normal active site conformation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the peptidase A22A family.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.-" evidence="11"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2SSY7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005002593.1">
        <property type="protein sequence ID" value="ENSCJPP00005001563.1"/>
        <property type="gene ID" value="ENSCJPG00005001573.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157923"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070765">
        <property type="term" value="C:gamma-secretase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042500">
        <property type="term" value="F:aspartic endopeptidase activity, intramembrane cleaving"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034205">
        <property type="term" value="P:amyloid-beta formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055074">
        <property type="term" value="P:calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006509">
        <property type="term" value="P:membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110097">
        <property type="term" value="P:regulation of calcium import into the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.100:FF:000001">
        <property type="entry name" value="Presenilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.100">
        <property type="entry name" value="Presenilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001493">
        <property type="entry name" value="Pept_A22A_PS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001108">
        <property type="entry name" value="Peptidase_A22A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006639">
        <property type="entry name" value="Preselin/SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042524">
        <property type="entry name" value="Presenilin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10202">
        <property type="entry name" value="PRESENILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10202:SF24">
        <property type="entry name" value="PRESENILIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01080">
        <property type="entry name" value="Presenilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01072">
        <property type="entry name" value="PRESENILIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01074">
        <property type="entry name" value="PRESENILIN2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00730">
        <property type="entry name" value="PSN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 11" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="2 11" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="237"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="259"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="421"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="318"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="335"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005001563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="456" mass="51088" checksum="A483B8FCC3915444" modified="2022-01-19" version="1">MITFMNNSDSEDEPCNERTSLMSAESPPVPSYQDGLQASETREAQTHRKRQTGSSRSPNNVADEDASDSDVRVRESALENEEEELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRFYTEKNGQLIYTPFSEDTPSVGQRLLNSVLNTIIMISVIVVMTVFLVVLYKYRCYKFIHGWLILSSFMLLFLFTYIYLGEVLKTYNVAMDYPTVILIIWNFGAVGMICIHWKGPLQLQQAYLIMISALMALVFIKYLPEWTAWLILAAISVYDLIAVLCPKGPLRMLVETAQERNEPIFPALIYSSAMIWTVGMAKPDTAAKGQSQQTWDAEDGRENHSSTSNSDSQILDTRNPAPSHPITLEEMEEEERGVKLGLGDFIFYSVLVGKAAATPSGDWNTTLACFVAILIGLCLTLLLLAVFKKALPALPISITFGLIFYFSTDNLVRPFMDTLASHQLYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SU35</accession>
    <name>A0A8C2SU35_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TATA-box binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TBP</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015713410.1">
        <property type="nucleotide sequence ID" value="XM_015857924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SU35"/>
    <dbReference type="Ensembl" id="ENSCJPT00005006607.1">
        <property type="protein sequence ID" value="ENSCJPP00005003788.1"/>
        <property type="gene ID" value="ENSCJPG00005003910.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107311439"/>
    <dbReference type="KEGG" id="cjo:107311439"/>
    <dbReference type="CTD" id="6908"/>
    <dbReference type="GeneTree" id="ENSGT00940000157474"/>
    <dbReference type="OrthoDB" id="2127950at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000791">
        <property type="term" value="C:euchromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001674">
        <property type="term" value="C:female germ cell nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001939">
        <property type="term" value="C:female pronucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001673">
        <property type="term" value="C:male germ cell nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001940">
        <property type="term" value="C:male pronucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005668">
        <property type="term" value="C:RNA polymerase transcription factor SL1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005672">
        <property type="term" value="C:transcription factor TFIIA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017162">
        <property type="term" value="F:aryl hydrocarbon receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001164">
        <property type="term" value="F:RNA polymerase I core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000979">
        <property type="term" value="F:RNA polymerase II core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000995">
        <property type="term" value="F:RNA polymerase III general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001093">
        <property type="term" value="F:TFIIB-class transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042789">
        <property type="term" value="P:mRNA transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060261">
        <property type="term" value="P:positive regulation of transcription initiation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd04516">
        <property type="entry name" value="TBP_eukaryotes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000001">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000002">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00408">
        <property type="entry name" value="TATA_bind_prot_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000814">
        <property type="entry name" value="TBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030491">
        <property type="entry name" value="TBP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033710">
        <property type="entry name" value="TBP_eukaryotic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10126">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00352">
        <property type="entry name" value="TBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00686">
        <property type="entry name" value="TIFACTORIID"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00351">
        <property type="entry name" value="TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="52"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="57"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005003788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="303" mass="33304" checksum="8791E234D1897522" modified="2022-01-19" version="1">MDQNNSLPPYAQGLASPQGAMTPGIPIFSPMMPYGTGLTPQPVQSTNSLSILEEQQRQQQQQQQAAQQSTSQQATQGTSGQTPQLFHSQTLTTAPLPGTTPLYPSPMTPMTPITPATPASESSGIVPQLQNIVSTVNLGCKLDLKTIALRARNAEYNPKRFAAVIMRIREPRTTALIFSSGKMVCTGAKSEEQSRLAARKYARVVQKLGFPAKFLDFKIQNMVGSCDVKFPIRLEGLVLTHQQFSSYEPELFPGLIYRMIKPRIVLLIFVSGKVVLTGAKVRAEIYEAFENIYPILKGFRKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SW33</accession>
    <name>A0A8C2SW33_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Bardet-Biedl syndrome 7 protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BBS7</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of BBSome complex.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015717394.1">
        <property type="nucleotide sequence ID" value="XM_015861908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SW33"/>
    <dbReference type="Ensembl" id="ENSCJPT00005006106.1">
        <property type="protein sequence ID" value="ENSCJPP00005003456.1"/>
        <property type="gene ID" value="ENSCJPG00005003622.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107313560"/>
    <dbReference type="KEGG" id="cjo:107313560"/>
    <dbReference type="CTD" id="55212"/>
    <dbReference type="GeneTree" id="ENSGT00390000012346"/>
    <dbReference type="OrthoDB" id="414590at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034464">
        <property type="term" value="C:BBSome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060170">
        <property type="term" value="C:ciliary membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001750">
        <property type="term" value="C:photoreceptor outer segment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061629">
        <property type="term" value="F:RNA polymerase II-specific DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001654">
        <property type="term" value="P:eye development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045444">
        <property type="term" value="P:fat cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007507">
        <property type="term" value="P:heart development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060173">
        <property type="term" value="P:limb development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032436">
        <property type="term" value="P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903929">
        <property type="term" value="P:primary palate development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007224">
        <property type="term" value="P:smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016575">
        <property type="entry name" value="Bardet-Biedl_syndrome_7_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056334">
        <property type="entry name" value="BBS7_GAE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056335">
        <property type="entry name" value="BBS7_hairpin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056333">
        <property type="entry name" value="BBS7_pf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056332">
        <property type="entry name" value="Beta-prop_BBS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16074">
        <property type="entry name" value="BARDET-BIEDL SYNDROME 7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16074:SF4">
        <property type="entry name" value="BARDET-BIEDL SYNDROME 7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23360">
        <property type="entry name" value="BBS7_GAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23349">
        <property type="entry name" value="BBS7_hp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23361">
        <property type="entry name" value="BBS7_pf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23743">
        <property type="entry name" value="Beta-prop_BBS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011091">
        <property type="entry name" value="BBS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0966">Cell projection</keyword>
    <keyword evidence="1" id="KW-0969">Cilium</keyword>
    <keyword evidence="1" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="BBS7 beta-propeller" evidence="6">
        <location>
            <begin position="21"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="BBS7 GAE" evidence="4">
        <location>
            <begin position="377"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="BBS7 platform" evidence="5">
        <location>
            <begin position="494"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="BBS7 helical hairpin" evidence="3">
        <location>
            <begin position="599"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="335"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="615"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR011091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005003456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="716" mass="79973" checksum="B5679AA4E6C36DF0" modified="2022-01-19" version="1">MELSLSRVDYMQVGVTAQKTMRLLPASGRRATQKVVVGDQDGVITCFGIKKGEPVTVFKTLPGPKIARLELGGALNTPQEKVFVATGSDVRGFTKRGKQFLSFETNLTEDIKAMHISGADLFLCASYIYNHYCDCKDKHYYLSRDKINDVLCLPVDKVNCITPVLACQDRVLRVLQGSDLLYEVEVPGPPTVLALHNGDGGDSGEEIVYGTSDGKLGLIQITGSASVPKWEIENEKRRGGILCIDSFDILRDGVKELLVGRDDGVLEVYSFESADDPVLRYDYVLSESISSIQGGCVGKDGYDEVLACTYSGWLTGLTTELAYREGGSGEEVKLSQEMQSKISSLRNEVEHLQMKVLGEREKYQQSAQSSSAVSSVPAFSVNDKFTLNKDDASYSLILEVQAAIDIILVQSDVPVDLLDVDKNSAVVSFSNCDSDPNGNCLLATYRCQANTTRLELKIRSIEGRYGTLQAYVTPRIQPKTCQVYQYQIKPLSLHQRTHSIDHDRPMNTLMLKGQFSFAEIHSWVVFCLPEVPERTPPGETVTFYFQNTFLGTQLESTYRIGEGCFKSDNISTISILKDVLSKEATKRKINLNISFDINEESVRHTLKLIHPKLEYQQLLAKKVHLIDALRELQVQEGNADFLVPEYRSILEEADQLLEEYKKQPAHLERLYGMITDLFIDKFKFRGTNVKSKVPLLLELLDGCEQDRLLAFFEAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SWS0</accession>
    <name>A0A8C2SWS0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RCC1-like G exchanging factor-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">RCC1L</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Guanine nucleotide exchange factor (GEF) for mitochondrial dynamin-related GTPase OPA1. Activates OPA1, by exchanging bound GDP for free GTP, and drives OPA1 and MFN1-dependent mitochondrial fusion. Plays an essential role in mitochondrial ribosome biogenesis. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation of core subunits of the oxidative phosphorylation system.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Forms a regulatory protein-RNA complex, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mt-rRNA. Interacts with 16S mt-rRNA; this interaction is direct. Interacts with OPA1; this interaction is direct.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015736404.1">
        <property type="nucleotide sequence ID" value="XM_015880918.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SWS0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005008204.1">
        <property type="protein sequence ID" value="ENSCJPP00005004981.1"/>
        <property type="gene ID" value="ENSCJPG00005004730.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107322657"/>
    <dbReference type="KEGG" id="cjo:107322657"/>
    <dbReference type="CTD" id="81554"/>
    <dbReference type="GeneTree" id="ENSGT00940000157317"/>
    <dbReference type="OrthoDB" id="70707at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008053">
        <property type="term" value="P:mitochondrial fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902775">
        <property type="term" value="P:mitochondrial large ribosomal subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070131">
        <property type="term" value="P:positive regulation of mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.30:FF:000024">
        <property type="entry name" value="RCC1-like G exchanging factor-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053035">
        <property type="entry name" value="Mitochondrial_GEF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46337">
        <property type="entry name" value="RCC1-LIKE G EXCHANGING FACTOR-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46337:SF1">
        <property type="entry name" value="RCC1-LIKE G EXCHANGING FACTOR-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="RCC1-like" evidence="11">
        <location>
            <begin position="52"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="10">
        <location>
            <begin position="54"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="10">
        <location>
            <begin position="118"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="10">
        <location>
            <begin position="182"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="10">
        <location>
            <begin position="238"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="10">
        <location>
            <begin position="291"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="10">
        <location>
            <begin position="343"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="10">
        <location>
            <begin position="401"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00059435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00065468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005004981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="452" mass="49210" checksum="3EE689193D72172A" modified="2022-01-19" version="1">MAALWRGLRAAWRPPVPSRGLAKPAGPPSARGLREADEAAPIFQYVGKAAKRKDRVFVWGFSYSGALGVPSFVKPDEGWKKPRRIQATPYRLETEDKITSAACGYGFTLLASNTTDITKVWGMGLNKDSQLGFQRSIRDRTKGYEYVLEPSPIPLPLEKPQKTRVLQVSCGRAHSLILTDSEGVFTMGNNSYGQCGRKVVEDEIYSESHLIHQLNDFDSRVVQVVCGQDHSLFRTKKGAVFACGWGADGQTGLGHYNITSVPTKLGGDIAGVNIIQVSSYGDSCLAVSDEGDLFGWGNSEYLQLASVTEATQVNVPRHLPFKIGKIKEAACGGTGNIVLTEEGGVYVWGYGILGKGPNLTEAAVPEMIPPSLFGWSDFSPDVRVAHVRCGLSHFAALTNKGELFVWGKNLRGCLGIGRMEDQYFPWRVTIPGEVVDVACGVDHMVSMVKSFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SXM7</accession>
    <name>A0A8C2SXM7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RabBD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Perinuclear region</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SXM7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005007582.1">
        <property type="protein sequence ID" value="ENSCJPP00005004545.1"/>
        <property type="gene ID" value="ENSCJPG00005004481.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183138"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017022">
        <property type="term" value="F:myosin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15753">
        <property type="entry name" value="FYVE_SlaC2-c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000018">
        <property type="entry name" value="Synaptotagmin-like 5, isoform CRA_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041282">
        <property type="entry name" value="FYVE_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051745">
        <property type="entry name" value="Intracell_Transport_Effector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010911">
        <property type="entry name" value="Rab_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14555">
        <property type="entry name" value="MYELIN-ASSOCIATED OLIGODENDROCYTIC BASIC PROTEIN MOBP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14555:SF6">
        <property type="entry name" value="RAB EFFECTOR MYRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02318">
        <property type="entry name" value="FYVE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50916">
        <property type="entry name" value="RABBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RabBD" evidence="4">
        <location>
            <begin position="4"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005004545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="129" mass="15108" checksum="C82657C468B612C1" modified="2022-01-19" version="1">MGRKLDLSGLTDEEAEHVLQVVQRDFSLRKKEEERLSEMKQKLDEEGNKCSILSKQQKFNEHCCIRCCSPFTFLINSKRQCQDCKYNICKSCSSYQKKEKAWICSVCQQAREEPRGISTVCCHLLYPFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SZP3</accession>
    <name>A0A8C2SZP3_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">CSNK2A1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="RefSeq" id="XP_015737528.1">
        <property type="nucleotide sequence ID" value="XM_015882042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SZP3"/>
    <dbReference type="SMR" id="A0A8C2SZP3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005009829.1">
        <property type="protein sequence ID" value="ENSCJPP00005006211.1"/>
        <property type="gene ID" value="ENSCJPG00005005828.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107323193"/>
    <dbReference type="KEGG" id="cjo:107323193"/>
    <dbReference type="CTD" id="1457"/>
    <dbReference type="GeneTree" id="ENSGT00390000004215"/>
    <dbReference type="OrthoDB" id="10254671at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14132">
        <property type="entry name" value="STKc_CK2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000059">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000088">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045216">
        <property type="entry name" value="CK2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054:SF16">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="39"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="335"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="335"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="347"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="391" mass="45191" checksum="8D9A28CB02B00C14" modified="2022-01-19" version="1">MSGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYPIVKDQARMGSSNMPGGSTPVSSASMMSGISSVPTPSPLGPLAGSPVISATTTLGMPVPAAAGAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T069</accession>
    <name>A0A8C2T069_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">small monomeric GTPase</fullName>
            <ecNumber evidence="3">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">RIT2</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="3"/>
    <dbReference type="RefSeq" id="XP_032297253.1">
        <property type="nucleotide sequence ID" value="XM_032441362.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032297254.1">
        <property type="nucleotide sequence ID" value="XM_032441363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T069"/>
    <dbReference type="Ensembl" id="ENSCJPT00005009103.1">
        <property type="protein sequence ID" value="ENSCJPP00005005643.1"/>
        <property type="gene ID" value="ENSCJPG00005005369.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107325914"/>
    <dbReference type="KEGG" id="cjo:107325914"/>
    <dbReference type="CTD" id="6014"/>
    <dbReference type="GeneTree" id="ENSGT00940000161402"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome Z"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044297">
        <property type="term" value="C:cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097447">
        <property type="term" value="C:dendritic tree"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030215">
        <property type="term" value="F:semaphorin receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032507">
        <property type="term" value="P:maintenance of protein location in cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010977">
        <property type="term" value="P:negative regulation of neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010976">
        <property type="term" value="P:positive regulation of neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032489">
        <property type="term" value="P:regulation of Cdc42 protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030100">
        <property type="term" value="P:regulation of endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd04141">
        <property type="entry name" value="Rit_Rin_Ric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000343">
        <property type="entry name" value="Ras family gtpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005005643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="216" mass="24814" checksum="798F02D1B05FB727" modified="2022-01-19" version="1">MELENEISSSNNSSAGSREYKVVMLGAGGVGKSAMTMQFISHRFPDYHDPTIEDAYKTQVRIDDEPAYLDILDTAGQAEFTAMRDQYMRGGEGFIICYSITDRQSFQEAAEFKELIYCVRHTYDIPLVLVGNKTDLEEFRQVSTEEGMNLAREYSCSFFETSAALRFYIDDVFHGLVREIRRKESSLTVAEKKMKRKDSLWRKLKGSLRKKKESTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T3H9</accession>
    <name>A0A8C2T3H9_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Zinc finger MYND-type containing 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ZMYND12</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T3H9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005011956.1">
        <property type="protein sequence ID" value="ENSCJPP00005007797.1"/>
        <property type="gene ID" value="ENSCJPG00005007088.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000004248"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036126">
        <property type="term" value="C:sperm flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007288">
        <property type="term" value="P:sperm axoneme assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053248">
        <property type="entry name" value="Zinc_finger_MYND_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46533">
        <property type="entry name" value="ZINC FINGER MYND DOMAIN-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46533:SF1">
        <property type="entry name" value="ZINC FINGER MYND DOMAIN-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005007797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="187" mass="20913" checksum="80D7E9F9277E1645" modified="2022-01-19" version="1">LPSLTTEEERKHGVEQLVKRQKYIIDLASSMAQKFIFNGKHKTALPAALHALHFSTQVYGSSSVQLVPAYLLLAEACIGAGNLQQASNYLSQAQWIVLRTPDCSGAFQHRLHRGFGLLYVTDGNFDQALYHLAKDIYFASSTFGLKSVEVSGGYFLMANVFFRQNKMDIADSLYAELKPSKQKQFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T496</accession>
    <name>A0A8C2T496_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Prosaposin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">PSAP</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Saposin-A and saposin-C stimulate the hydrolysis of glucosylceramide by beta-glucosylceramidase (EC 3.2.1.45) and galactosylceramide by beta-galactosylceramidase (EC 3.2.1.46). Saposin-C apparently acts by combining with the enzyme and acidic lipid to form an activated complex, rather than by solubilizing the substrate.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Saposin-B stimulates the hydrolysis of galacto-cerebroside sulfate by arylsulfatase A (EC 3.1.6.8), GM1 gangliosides by beta-galactosidase (EC 3.2.1.23) and globotriaosylceramide by alpha-galactosidase A (EC 3.2.1.22). Saposin-B forms a solubilizing complex with the substrates of the sphingolipid hydrolases.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Saposin-D is a specific sphingomyelin phosphodiesterase activator (EC 3.1.4.12).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T496"/>
    <dbReference type="Ensembl" id="ENSCJPT00005011309.1">
        <property type="protein sequence ID" value="ENSCJPP00005007299.1"/>
        <property type="gene ID" value="ENSCJPG00005006736.1"/>
    </dbReference>
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        <property type="component" value="Chromosome 6"/>
    </dbReference>
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        <property type="term" value="C:extracellular region"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:lysosome"/>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007193">
        <property type="term" value="P:adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019216">
        <property type="term" value="P:regulation of lipid metabolic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:sphingolipid metabolic process"/>
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    </dbReference>
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        <property type="entry name" value="Proactivator polypeptide"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="prosaposin isoform X2"/>
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        <property type="entry name" value="Saposin-like"/>
        <property type="match status" value="4"/>
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        <property type="entry name" value="SAP_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007856">
        <property type="entry name" value="SapB_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008138">
        <property type="entry name" value="SapB_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008373">
        <property type="entry name" value="Saposin"/>
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    <dbReference type="InterPro" id="IPR011001">
        <property type="entry name" value="Saposin-like"/>
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        <property type="entry name" value="Saposin_chordata"/>
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    <dbReference type="InterPro" id="IPR008139">
        <property type="entry name" value="SaposinB_dom"/>
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    <dbReference type="InterPro" id="IPR051428">
        <property type="entry name" value="Sphingo_Act-Surfact_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11480:SF36">
        <property type="entry name" value="PROSAPOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11480">
        <property type="entry name" value="SAPOSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02199">
        <property type="entry name" value="SapA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SapB_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03489">
        <property type="entry name" value="SapB_2"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="Saposin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01797">
        <property type="entry name" value="SAPOSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00162">
        <property type="entry name" value="SAPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00741">
        <property type="entry name" value="SapB"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47862">
        <property type="entry name" value="Saposin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51110">
        <property type="entry name" value="SAP_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50015">
        <property type="entry name" value="SAP_B"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0458">Lysosome</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 14" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034820917" description="Prosaposin" evidence="14">
        <location>
            <begin position="18"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin A-type" evidence="16">
        <location>
            <begin position="19"/>
            <end position="59"/>
        </location>
    </feature>
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        <location>
            <begin position="60"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="15">
        <location>
            <begin position="193"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="15">
        <location>
            <begin position="327"/>
            <end position="408"/>
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    </feature>
    <feature type="domain" description="Saposin B-type" evidence="15">
        <location>
            <begin position="419"/>
            <end position="460"/>
        </location>
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        <location>
            <begin position="64"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="67"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="95"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="197"/>
            <end position="293"/>
        </location>
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    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="200"/>
            <end position="287"/>
        </location>
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    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="229"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="331"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="334"/>
            <end position="398"/>
        </location>
    </feature>
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        <location>
            <begin position="362"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00004613"/>
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            <dbReference type="ARBA" id="ARBA00022525"/>
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    </evidence>
    <sequence length="559" mass="61933" checksum="60EF94E98AA2DF8D" modified="2022-01-19" version="1">MARRLLTFLGLLAAAVASPVLWQKDCVKGPEVWCQSLRTASQCGAVKHCQQNVWSKPTVNSIPCDLCKELVTVVGKVLKDNGTEDEIRSYLEKTCEFLPDQGLASECKEIVDSYLPVIMDMIKEEFDKPEVVCSALSLCQSLQKHLAAMKLQKQLQSNKIPELDFSELTSPFMANVPLLLYPQDKPKQKSKGTEDVCQDCIRLVTDVQEAVRTNETFVKSLVAHAKEECDRLGPGMSDMCKSYISEYSDLAIQMMMHMAVFSNAGLCFCLHNMMLLDALKKQPKDICSMVGFCSSVKSVPLQTLVPAQVVHEVKMETVEKAAVQEKTFSVCEICETMVKEVTGLLESNKTEEEIVHEMEVVCYLLPASVKDQCKDFIEVYGQALIDMLLEATNPEAVCVMLKCCAANKLPQQPVVVKPAGGFCDICKMVVAYADKELEKNATTTEIEALLEKVCHFLPESVSDQVKHQAKKQFCALSKAKDDLSTHAAGADLFSHPILARVFPSLFSTKAEQSPMYNRERQRERKLCGRGVCRGVEGSRPDLGSPGCVTACLPVSARQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T5N7</accession>
    <name>A0A8C2T5N7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Toll-like receptor 5</fullName>
        </recommendedName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Pattern recognition receptor (PRR) located on the cell surface that participates in the activation of innate immunity and inflammatory response. Recognizes small molecular motifs named pathogen-associated molecular pattern (PAMPs) expressed by pathogens and microbe-associated molecular patterns (MAMPs) usually expressed by resident microbiota. Upon ligand binding such as bacterial flagellins, recruits intracellular adapter proteins MYD88 and TRIF leading to NF-kappa-B activation, cytokine secretion and induction of the inflammatory response. Plays thereby an important role in the relationship between the intestinal epithelium and enteric microbes and contributes to the gut microbiota composition throughout life.</text>
    </comment>
    <comment type="subunit">
        <text evidence="17">Homodimer. Interacts with MYD88 (via TIR domain). Interacts with TICAM1 (via TIR domain). Interacts with UNC93B1; this interaction is essential for proper TLR5 localization to the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 19">Belongs to the Toll-like receptor family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T5N7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005012073.1">
        <property type="protein sequence ID" value="ENSCJPP00005007876.1"/>
        <property type="gene ID" value="ENSCJPG00005007153.1"/>
    </dbReference>
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        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002224">
        <property type="term" value="P:toll-like receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10140:FF:000001">
        <property type="entry name" value="Toll-like receptor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000306">
        <property type="entry name" value="Toll-like receptor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000365">
        <property type="entry name" value="Toll-like receptor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000592">
        <property type="entry name" value="Toll-like receptor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017241">
        <property type="entry name" value="Toll-like_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365">
        <property type="entry name" value="TOLL-LIKE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365:SF525">
        <property type="entry name" value="TOLL-LIKE RECEPTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01582">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037595">
        <property type="entry name" value="Toll-like_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01537">
        <property type="entry name" value="INTRLKN1R1F"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 19" id="KW-0391">Immunity</keyword>
    <keyword evidence="15 19" id="KW-0395">Inflammatory response</keyword>
    <keyword evidence="4 19" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13 19" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 20" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
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        <location>
            <begin position="23"/>
            <end position="861"/>
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            <begin position="693"/>
            <end position="838"/>
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    <sequence length="861" mass="98993" checksum="3086EACD27EC70CE" modified="2022-01-19" version="1">MMLHQQLIIAFGILLAGDICTSRSCYLEDQVAMYNSCNLTSVPLVPKDTAKLFLTYNYIRQVTATSFPLLENLFLLEIGTQKVFPLYIGKEAFRNLPNLRVLDLGFNNILLLDLDSFVGLRRLTILGLFQNNLGDSILEERYFQDLSSLEELNLSGNQITKLYPHPLFFNLTILKSVDLKFNNISNLCDSNLTSFQGKHFSFFSLSSNALYKTDKKVWAKCPNPFRNITFDTLDVSENGWSTERVQYFCTAIKGTQIKYLSFRTHIIGSGFGFNNLKNPDKNTFTGLAKSDLNLLDISRGFIFSLNSLIFESLRNLEFLNLFRNKVNQIQEQAFFGLENLKILNLSSNLLGELYDYTFEGLHSIMYIDLQQNHIGMIGQKSFSKLVNLKIIDLRDNAIKTLPSFPHLTYAYLGDNKLMSVAHTAIAATHIELERNWLANLGDLYVLFRVPDVQYLFLKQNRFSYCVKHGNAIENSQLIYMDLGENMLQLVWERGLCLDVFRSLSKLQVLHLNNNYLSALPQEIFNGLTSLKILNLASNLLSHLSLGVFPESLINLNLSGNQLFSPKPEVFMTLSILDITHNKYVCDCALKSLLVWLNETNVTLAGSESDRYCVYPPALAGVPVSLLTYDDCDEDELQQTLRFSLFIFITVTLLMFQMSAIILTRCRGICFVCYKTITKTLIGSHPPAADTSEYMYDAYLCYSKNDFEWVQNSLLKHLDSQYFYKNRFTLCFEERDFLPGEEHINNIRDAIWKSRKTICVVTKQFLKDGWCVEAFNFAQSRYFSDLKEVLIMVVVGSLSQYQLMKHKPIRIFLQRSRYLRWPEDYQDIDWFLDSLASQILKEKKVQRDVSGTELQTIATVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T6W2</accession>
    <name>A0A8C2T6W2_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="26">Hyperpolarization activated cyclic nucleotide gated potassium channel 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="26" type="primary">HCN4</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>Na(+)(in) = Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:34963"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the potassium channel HCN family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T6W2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005012754.1">
        <property type="protein sequence ID" value="ENSCJPP00005008404.1"/>
        <property type="gene ID" value="ENSCJPG00005007514.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154743"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098855">
        <property type="term" value="C:HCN channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030552">
        <property type="term" value="F:cAMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005222">
        <property type="term" value="F:intracellularly cAMP-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0086041">
        <property type="term" value="F:voltage-gated potassium channel activity involved in SA node cell action potential depolarization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005248">
        <property type="term" value="F:voltage-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071320">
        <property type="term" value="P:cellular response to cAMP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071321">
        <property type="term" value="P:cellular response to cGMP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098909">
        <property type="term" value="P:regulation of cardiac muscle cell action potential involved in regulation of contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0086091">
        <property type="term" value="P:regulation of heart rate by cardiac conduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003254">
        <property type="term" value="P:regulation of membrane depolarization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098719">
        <property type="term" value="P:sodium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000031">
        <property type="entry name" value="Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.630:FF:000002">
        <property type="entry name" value="Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000007">
        <property type="entry name" value="Putative potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.630">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013621">
        <property type="entry name" value="Ion_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051413">
        <property type="entry name" value="K/Na_HCN_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003938">
        <property type="entry name" value="K_chnl_volt-dep_EAG/ELK/ERG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45689">
        <property type="entry name" value="I[[H]] CHANNEL, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45689:SF4">
        <property type="entry name" value="POTASSIUM_SODIUM HYPERPOLARIZATION-ACTIVATED CYCLIC NUCLEOTIDE-GATED CHANNEL 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08412">
        <property type="entry name" value="Ion_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01463">
        <property type="entry name" value="EAGCHANLFMLY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0114">cAMP</keyword>
    <keyword evidence="7" id="KW-0116">cAMP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="20" id="KW-0407">Ion channel</keyword>
    <keyword evidence="15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="19" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="16 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0630">Potassium</keyword>
    <keyword evidence="10" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="6" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0915">Sodium</keyword>
    <keyword evidence="4" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="18" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="8 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 24" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="11" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="235"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="464"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="25">
        <location>
            <begin position="567"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="810"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="859"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1026"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1111"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="23">
        <location>
            <begin position="137"/>
            <end position="149"/>
        </location>
    </feature>
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        <location>
            <begin position="864"/>
            <end position="885"/>
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    </feature>
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        <location>
            <begin position="895"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="919"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="952"/>
            <end position="963"/>
        </location>
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        <location>
            <begin position="979"/>
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        </location>
    </feature>
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        <location>
            <begin position="1038"/>
            <end position="1058"/>
        </location>
    </feature>
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        <location>
            <begin position="1061"/>
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            <begin position="1111"/>
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            <begin position="1121"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00004651"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00006305"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00036239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005008404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1209" mass="131317" checksum="93E9B4294EB4792A" modified="2022-01-19" version="1">MDKLPPSMRKRLYSLPQQIGPKASIMDEEEDSDKDTRRKSIRLKPLPSPSAGSTRALGGDPGRGEDSGLVETEAGSKGAKTSTNGDCRRFKGSLSSLTSRHLHDAAEEKRLIGGEGEPASPGEDKSPSDSGETQGLPVPPPPASPPEPQQQPLRACSSTSIKVEGGGGCDQITPDEEQRLGQAGFMQRQFGAMLQPGVNKFSLRMFGSQKAVEREQERVKSAGFWIIHPYSDFRFYWDFTMLLLMVGNLIIIPVGITFFKDENTTPWIVFNVVSDTFFLIDLVLNFRTGIVVEDNTEIILDPQRIKMKYLKSWFVVDFISSIPVDYIFLIVEKGIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIVNLIGMMLLLCHWDGCLQFLVPMLQDFPDDCWVSLNRMVNDSWGKQYSYALFKAMSHMLCIGYGQQAPVGMSDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADMRQRIHDYYEHRYQGKMFDEESILGELSEPLREEIVNFNCRKLVATMPLFANADPNFVTSMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHGVVSILTKGNKETKLSDGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSILLHKVQHDLNSGVFNYQENEIIQQIVQHDREMAHCAHNVQAAAAAAAAASTPTPVIWTPLIQAPLQAAAATTSVAIALTHHPRLPTAIFRPPVSVLGSLGQQSSQTPRQLKRLQSLIPSTGPSAVGSPSSTPSQLHTPGAETPSSSSYHIQQLAGYSAAAGLGQFQVGSPPAGSGQQGLSGVSSAGLSQLQQAPTGSPIGTAQPLQQQQQQLQRQPSLSSGGFGHFQQAAASSPSTSLTQLSSNSPTSLLNQFQPTTRPLQGGQLQQLSGSGTLGGINHFQPPPSSNSPSSSLSQLAQASGGPSSGLCQTQPSALGSLTGTIAQLHQERSPFASVSPLQQPGVASPSYTPSGLSPPTQSPVATRTFQCGPLGASGSHSSLLLPQTASPPPQILQSKSTPPVPPGRLNQDIKLISASQPSLPQELAQTLSQSSHSSRESVSSFSPFPGGGTGLLGKPCSSIPGRVTLPRQMSSGSLPHPLVFGAGAAGPASLTAGGRKESTVLTGDLEPVRSKLPSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T6W7</accession>
    <name>A0A8C2T6W7_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Synaptophysin like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">SYPL1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synaptophysin/synaptobrevin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T6W7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005011127.1">
        <property type="protein sequence ID" value="ENSCJPP00005007177.1"/>
        <property type="gene ID" value="ENSCJPG00005006609.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234637"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030141">
        <property type="term" value="C:secretory granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001285">
        <property type="entry name" value="Synaptophysin/porin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10306">
        <property type="entry name" value="SYNAPTOPHYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10306:SF9">
        <property type="entry name" value="SYNAPTOPHYSIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00220">
        <property type="entry name" value="SYNAPTOPHYSN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51225">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="9">
        <location>
            <begin position="15"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005007177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="239" mass="26366" checksum="47239A204765B669" modified="2025-10-08" version="2">MWSSRMFGLQVDCGLLLEPLGFIKLLEWIFSIFAFSTCGGFHGETTLLVSCKGAVNQTVTAAFAYPFRLNTVRFSAPVSNHCAGTWTDTYLVGNFSSSAQFFVTLAVLAFLYCIAALVVYIGYKHVYQNNSKFPLIDLAVTIVTTFLWLVSTSAWAKALADIKISTGAGIIPLIDSCRAPNMICYFGSVTSMKTLNVSVVFGLLNMILWGGNIWFVYKDTDLHSQFIRGSQGMYSAQRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T765</accession>
    <name>A0A8C2T765_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">TSPAN15</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Part of TspanC8 subgroup, composed of 6 members that interact with the transmembrane metalloprotease ADAM10. This interaction is required for ADAM10 exit from the endoplasmic reticulum and for enzymatic maturation and trafficking to the cell surface as well as substrate specificity. Different TspanC8/ADAM10 complexes have distinct substrates. Promotes ADAM10-mediated cleavage of CDH2. Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Interacts with ADAM10; the interaction influences ADAM10 substrate specificity, endocytosis and turnover.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the tetraspanin (TM4SF) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015721876.1">
        <property type="nucleotide sequence ID" value="XM_015866390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T765"/>
    <dbReference type="Ensembl" id="ENSCJPT00005011291.1">
        <property type="protein sequence ID" value="ENSCJPP00005007285.1"/>
        <property type="gene ID" value="ENSCJPG00005006720.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107315734"/>
    <dbReference type="KEGG" id="cjo:107315734"/>
    <dbReference type="CTD" id="23555"/>
    <dbReference type="GeneTree" id="ENSGT00940000157973"/>
    <dbReference type="OrthoDB" id="10051815at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030054">
        <property type="term" value="C:cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097197">
        <property type="term" value="C:tetraspanin-enriched microdomain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045746">
        <property type="term" value="P:negative regulation of Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051043">
        <property type="term" value="P:regulation of membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd03158">
        <property type="entry name" value="penumbra_like_LEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1450.10:FF:000011">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000301">
        <property type="entry name" value="Tetraspanin_animals"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF159">
        <property type="entry name" value="TETRASPANIN-15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002419">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00056423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00065909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005007285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="295" mass="33075" checksum="096E3AEA2E3A99EB" modified="2022-01-19" version="1">MATGDAEQARYCARLSYLCLKFSLITYCTAFWVIGGLVLAVGIYAEVERQKYKTLESAFLAPAIILILLGIIMFLVSFVGVLASLRDNLCLLQAFMYILGLCLMMELAGAVVALIFRNQTIKFLNDNIRRGIENYYDDLDFKNIMDSVQKRFKCCGGEDYTDWSKNVYHDCAAPGPLACGVPYTCCVRNKTDIINTMCGYKTIDKERLSIQDVIYVRGCTNAVLIWFLDNYSIMAGVLLGILLPQFLGVLLSLLYITRVEDIIAEHKLGESLFGEMRQRPDPDFSNGGCCMCYPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T795</accession>
    <name>A0A8C2T795_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dual-specificity kinase</fullName>
            <ecNumber evidence="2">2.7.12.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">CLK3</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.1" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2T795"/>
    <dbReference type="Ensembl" id="ENSCJPT00005013112.1">
        <property type="protein sequence ID" value="ENSCJPP00005008677.1"/>
        <property type="gene ID" value="ENSCJPG00005007545.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160359"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045111">
        <property type="term" value="C:intermediate filament cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd14214">
        <property type="entry name" value="PKc_CLK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000145">
        <property type="entry name" value="Dual specificity protein kinase CLK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000061">
        <property type="entry name" value="Dual specificity protein kinase CLK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051175">
        <property type="entry name" value="CLK_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646:SF10">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE CLK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE DOA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="174"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="114"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="122"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="136"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00051680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005008677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="511" mass="60591" checksum="E5ED7BE4958BA86E" modified="2022-01-19" version="1">MHHCKRYRSPEHDNCWEPRWKRRRARSGAHGNRPLQRDTTTRPNVPCGSCVAYMALGAVTPLRLTCCLCCSHDRMPYHRRYRDRRDSDAYRLEERSPSLDEDYYSTRTRNWRRSRDREQYRDRKHQHHCRRRRTRSCSSTSSRSQQSSKRSRSVEDDKEGHLVCRIGDWLQERYEIVGSLGEGTFGKVVECVDHARGKSQVALKIIKNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPQIRHMAYQLCHALKFLHDNQLTHTDLKPENILFVNSDFDTLYNEKKSCEEKSIRNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSTGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFHKGNLVWDENTSDGRYVQENCKPLRTYMLHDSLEHAQLFDLIRRMLEFDPSRRITFSEALLHPFFAGLSAEERMLCGRGTSRDLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T9K7</accession>
    <name>A0A8C2T9K7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histone H3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histone H3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T9K7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005014464.1">
        <property type="protein sequence ID" value="ENSCJPP00005009709.1"/>
        <property type="gene ID" value="ENSCJPG00005008503.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005014465.1">
        <property type="protein sequence ID" value="ENSCJPP00005009710.1"/>
        <property type="gene ID" value="ENSCJPG00005008505.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286903"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00322">
        <property type="entry name" value="HISTONE_H3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005009710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="69" mass="6744" checksum="B872FE4A6A7A8E09" modified="2022-01-19" version="1">MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHPCGSAAPWTSGSAGSRAAPPCRAGSGAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TA84</accession>
    <name>A0A8C2TA84_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Zinc finger BED-type containing 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ZBED4</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015707650.1">
        <property type="nucleotide sequence ID" value="XM_015852164.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TA84"/>
    <dbReference type="Ensembl" id="ENSCJPT00005014196.1">
        <property type="protein sequence ID" value="ENSCJPP00005009515.1"/>
        <property type="gene ID" value="ENSCJPG00005008348.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107308322"/>
    <dbReference type="KEGG" id="cjo:107308322"/>
    <dbReference type="CTD" id="9889"/>
    <dbReference type="GeneTree" id="ENSGT00940000161365"/>
    <dbReference type="OrthoDB" id="10057873at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF4">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02892">
        <property type="entry name" value="zf-BED"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00614">
        <property type="entry name" value="ZnF_BED"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140996">
        <property type="entry name" value="Hermes dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50808">
        <property type="entry name" value="ZF_BED"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BED-type" evidence="11">
        <location>
            <begin position="113"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="BED-type" evidence="11">
        <location>
            <begin position="282"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="BED-type" evidence="11">
        <location>
            <begin position="453"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="BED-type" evidence="11">
        <location>
            <begin position="555"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="361"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="361"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005009515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1172" mass="132707" checksum="895A2A44764A1E23" modified="2022-01-19" version="1">MENSKSRSPIMDGNFILGKINNLKVEQEEDGINCTLERMDIKTEQDEFKHADSSDEQEDKEKNFISNNPSKYLSTENEDDYGSLFSQYSSTLYDVAMEAVTQSLLSSRNISSRKKSPAWNHFFISPRDSTKAICMYCMKEFSRGKNEKDLSTSCLMRHVRRAHPTVLIQENGTMPNISSFSSPTLLLPPQSADMGDLSSMLSPIKLVKKMASKIPSPDRIIEESVSIVSSEEIADLSVSEKCNKEEVMVGSSLQLPNNQYDETVENVAEKTVVIPKNASGSRRRSAVWKHFYLSPLDNSKAVCIHCMNEFSRGKNGKDLGTSCLIRHMWRAHRSIVLQENGGGTSIPPLYTTPPTLLPSLLPSDSDLNSMSSSPGKLMKESASVSSSPDRISEEMHTNLSSGDVLVEDSMLSSSDDIGEVSFVSSPEKHCEGLGPLIFEPTAVFQQNKRIMKRLKSEVWHHFSLSSADSLKAVCRYCSCMISRGKKGDVGTSCLMRHLYRRHPDIIGNQKSCLDVSLANSPYATLASAECSSSKLTELPTMVTHDNQIIFPVNSKKTSKLWNHFSICSADSTKVICMHCGRTISRGKKPTNLGTSCLLRHLQRFHNNVLKTDVSETVLSTSTDNHMPLSTELLASATFDETNEKFCDSHPVAKKITSLVAEMIALDLQPYSFVDNIGFNRLLEYLQPQYSLPSPSYFSRTAIPDMYDNVRQIIISHLKEAESGVIHFTSGIWMSNQTREYLTLTAHWVTFESSFRPQCEDYHCSALLNVSQIDCDYNGISIQKQLEYWWEMWITSIGLQIGITVTDNHSIEKTLNEGDHSSVQCFSHTVNVIVNEAIKSQRMVQNLLSIARKICERVHRSAKAKEKLAELQKEYELPQHQLIQDVPSKWNTSFHMLERLIEQKRAIDEMSIECSFRELISCDQWEVMQSVCHALKPFEAASREMSTHMSTLSQVIPMIHILNRKIEMLFEETMGIDTMLKSLKEAMVSRLSSTLHDPRYIFATLLDPRYKTSLFTEEEAEQYKQDLIRELEIMSSTSEDDKPVSNGCDIGSPSTNSYGDDNIWSLMGDMKKTKDLKERAKLPEEMVLSYLEEEVLEHNCDPLTYWNFKKSSWPVLSKLAVRFLGCPPSIVPSERLFNTSNESNNFSQSRLMIEHFEKLIFLKVNLPLIYFQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TAU3</accession>
    <name>A0A8C2TAU3_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">U2 small nuclear RNA auxiliary factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">U2AF1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the splicing factor SR family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TAU3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005014821.1">
        <property type="protein sequence ID" value="ENSCJPP00005009966.1"/>
        <property type="gene ID" value="ENSCJPG00005008722.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183152"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089701">
        <property type="term" value="C:U2AF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050733">
        <property type="term" value="F:RS domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12538">
        <property type="entry name" value="RRM_U2AF35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000055">
        <property type="entry name" value="Splicing factor U2AF 35 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009145">
        <property type="entry name" value="U2AF_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12620">
        <property type="entry name" value="U2 SNRNP AUXILIARY FACTOR, SMALL SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01848">
        <property type="entry name" value="U2AUXFACTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRM" evidence="14">
        <location>
            <begin position="114"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="15">
        <location>
            <begin position="219"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="12">
        <location>
            <begin position="219"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="255"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="289"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005009966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="306" mass="35595" checksum="A65A4AA26741D287" modified="2022-01-19" version="1">MRTERRRPPPSFSGPAEQRFRRGGCDVCGGRRAVRRAGGGRWRSIWPPSSEQRRTKSTVRFISKSELAVMETDVLGCTTNQHLARKRCCCKLACSRDQPVLTFRQLDFKKNGTNTILIQNIYRNPQNSAQTADGSHCAVSDVEMQEHYDEFFEEVFTEMEEKYGEVEEMNVCDNLGDHLVGNVYVKFRREEDAEKAVIDLNNRWFNGQPIHAELSPVTDFREACCRQYEMGECTRGGFCNFMHLKPISRELRRELYGRRRKKHRSRSRSRERRSRSRDRGRGGGGGGGGRERDRRRSRDRERSGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TBA9</accession>
    <name>A0A8C2TBA9_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Centromere protein W</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">CENPW</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPW has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Heterodimer with CENPT; this dimer coassembles with CENPS-CENPX heterodimers at centromeres to form the tetrameric CENP-T-W-S-X complex, which is a subcomplex of the large constitutive centromere-associated network (CCAN, also known as the interphase centromere complex or ICEN). Interacts with NPM1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
            <location evidence="2">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the CENP-W/WIP1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015714066.1">
        <property type="nucleotide sequence ID" value="XM_015858580.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TBA9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005015509.1">
        <property type="protein sequence ID" value="ENSCJPP00005010490.1"/>
        <property type="gene ID" value="ENSCJPG00005009125.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107311758"/>
    <dbReference type="KEGG" id="cjo:107311758"/>
    <dbReference type="CTD" id="387103"/>
    <dbReference type="GeneTree" id="ENSGT00390000010369"/>
    <dbReference type="OrthoDB" id="2543597at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000939">
        <property type="term" value="C:inner kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd13732">
        <property type="entry name" value="HFD_CENP-W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000053">
        <property type="entry name" value="Centromere protein W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028847">
        <property type="entry name" value="CENP-W"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052484">
        <property type="entry name" value="CENP-W/WIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34832">
        <property type="entry name" value="CENTROMERE PROTEIN W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34832:SF1">
        <property type="entry name" value="CENTROMERE PROTEIN W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15510">
        <property type="entry name" value="CENP-W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="10" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00058930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00063642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00068532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005010490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="76" mass="8726" checksum="773DECC289EF0044" modified="2022-01-19" version="1">MRRTVSRGTLRKIIKKHKPHLRLAANTDLLVHLSFLLFLQRLAEETRTNAFENKSKVIKPEHTVAAAKVILKKSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TD63</accession>
    <name>A0A8C2TD63_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="22">NudE neurodevelopment protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">NDE1</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Chromosome</location>
            <location evidence="5">Centromere</location>
            <location evidence="5">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cleavage furrow</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Microtubule organizing center</location>
            <location evidence="3">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the nudE family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TD63"/>
    <dbReference type="Ensembl" id="ENSCJPT00005017488.1">
        <property type="protein sequence ID" value="ENSCJPP00005012028.1"/>
        <property type="gene ID" value="ENSCJPG00005010263.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000000111"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032154">
        <property type="term" value="C:cleavage furrow"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031616">
        <property type="term" value="C:spindle pole centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051298">
        <property type="term" value="P:centrosome duplication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051642">
        <property type="term" value="P:centrosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021987">
        <property type="term" value="P:cerebral cortex development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007100">
        <property type="term" value="P:mitotic centrosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007405">
        <property type="term" value="P:neuroblast proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001764">
        <property type="term" value="P:neuron migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047496">
        <property type="term" value="P:vesicle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033494">
        <property type="entry name" value="NUDE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006964">
        <property type="entry name" value="NUDE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10921">
        <property type="entry name" value="NUCLEAR DISTRIBUTION PROTEIN NUDE HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10921:SF2">
        <property type="entry name" value="NUCLEAR DISTRIBUTION PROTEIN NUDE HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04880">
        <property type="entry name" value="NUDE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="10" id="KW-0132">Cell division</keyword>
    <keyword evidence="18" id="KW-0137">Centromere</keyword>
    <keyword evidence="7" id="KW-0158">Chromosome</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="19" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="16" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="13" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="12" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NUDE" evidence="21">
        <location>
            <begin position="135"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00007429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF04880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005012028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="363" mass="42006" checksum="B66D07E56CA98A4E" modified="2022-01-19" version="1">MEDSEEHRFSSVEEEARYWKELAVKYKQRAENTQEELREFQEGSREYEAELESQLQQTESRNRELLSENNRLRMDLESAKEKFEMQHSEWYRQISALEDDLAQTKAIKDQLQKYIRELEQANDDLERAKRAAIMSLEDFEQRLNQAIERNAFLESELDEKENLLESVQRLKDEARDLRQELAVQQKQEKPKTPMRTGLETERTDTAVQASLSLPSTPSVSRACKINIPTPATFRRGFEDSYCATPLTPAARISALKIMGDLLRKVGVSVYLIAKVLVKKELSETAARTEYLHWCLGKTGKNISGSKLVKCSLEIWPRFCIFLNKPETNKAHLCFSEMLHMCGVLISFLLQTSGRICAEKDRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TEH7</accession>
    <name>A0A8C2TEH7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">small monomeric GTPase</fullName>
            <ecNumber evidence="4">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC107310111</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2TEH7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005016906.1">
        <property type="protein sequence ID" value="ENSCJPP00005011561.1"/>
        <property type="gene ID" value="ENSCJPG00005009933.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000166646"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000586">
        <property type="entry name" value="Rab family GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005011561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="230" mass="25779" checksum="BE5490A3BB54282E" modified="2022-01-19" version="1">MAVPGQGDEGRSALLMKIVMAGESCVGKTSIVRRYTEPNAAAAFSSSSYLATIGIDFKVKCVTLNDKTVKLQIWDTAGQERFHTLSTSYFRGAQGFVLVYDITNLDSFQSVTSWMKDIHEKAGDEVDIVLLGNKCDKESERVVPKHKGEKLAWEHGIPFFETSAKDNVNIEDAFSVLTKEILEKQEQKDGKYIQQKERKPTQLKFLLSSEDCCKANQNSCYVYLPKVIDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TEI2</accession>
    <name>A0A8C2TEI2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ADP-ribosylation factor-like protein 3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TEI2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005015320.1">
        <property type="protein sequence ID" value="ENSCJPP00005010323.1"/>
        <property type="gene ID" value="ENSCJPG00005009013.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000164577"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000281">
        <property type="entry name" value="ADP-ribosylation factor-like protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044612">
        <property type="entry name" value="ARL2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45697">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12 14" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0519">Myristate</keyword>
    <keyword evidence="6 12 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="19"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="117"/>
            <end position="120"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005010323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="173" mass="19261" checksum="7826A2B35BF96890" modified="2022-01-19" version="1">MCKRLRGSPGQELRIVLLGLDNAGKTTLLKQLASEEVSTITPTQGFNIKSVHSHGFKLNIWDIGGQRAVRPYWRKYLGSTDLLVSQGLCPRVLSWQELAELTEEESLLGVPLLVFANKQDLVTAAPAAEIAEGLNLHMYRDREWQIQACSALSGEGVQDGMNWISKQIMSRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TEM9</accession>
    <name>A0A8C2TEM9_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nitric oxide associated 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">NOA1</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TEM9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005018100.1">
        <property type="protein sequence ID" value="ENSCJPP00005012491.1"/>
        <property type="gene ID" value="ENSCJPG00005010623.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000001695"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099617">
        <property type="term" value="C:matrix side of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061668">
        <property type="term" value="P:mitochondrial ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01855">
        <property type="entry name" value="YqeH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052807">
        <property type="entry name" value="Mito_transl_resp_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048422">
        <property type="entry name" value="NOA1/YqeH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46406">
        <property type="entry name" value="NITRIC OXIDE-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46406:SF1">
        <property type="entry name" value="NITRIC OXIDE-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21516">
        <property type="entry name" value="YqeH-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="3">
        <location>
            <begin position="400"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="NOA1/YqeH-like C-terminal" evidence="4">
        <location>
            <begin position="611"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="164"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="456"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="68"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005012491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="750" mass="81109" checksum="5ABD663215001F26" modified="2022-01-19" version="1">MTIQHASCHRSGVISSSSSSYCISTGEEGAGQAKAATTGPPIEAGERPGGRRPARPHSPSSASYMAAARREPRPAGTGEKEAENPAPSARRAAATGRRAAGTGSSAHARGEPRPAPSCGLLTLPVMLQLGRALLGRLRPARPWAARRWKALGGEEERFVFLEYEPEPEPPSPPTPLPPPPAPPAASPTGRAAARRRAGRERLLGEADPSVPPSGVGCSGCGAELQCRDTAAPGFVPADKYRSLCSGPGGAAGLRDAVCQRCWVMAHGGRLVRLELPAEQHRAVLSDALRSPPRHGRGPLLLYTLDVLELPDPVLPQLPALLSPDVPAAGLLVVGNKVDLLPADSPGHLGRLRQRVTAACLQAGIAREQLVDVRLVSAKTGFGMEGLVSRLQRSWKCAGDVYLLGATNSGKSTLFNALLQSDYCKSRAPDVVSRATVSSWPGTTLNLLKFPIINPTCDRIFRRQERLKEEAQKTEDQLSDEEKKHLNRLKKQGYLVGRVGRTFKRRESSVIDFDPDMLSYSIDEDPCHIPKKNEERQEFTYNEVKDARWCFDTPGIVKENCVLNLLTEKEVKQVLPTQAIIPRTFILKPGMVLFLAALGRVDYLQGEKPAWFSVVASRMLPVHVATLSSADAMYEKHAGQEFFKVPMGGKERMKEFPPLVPQDITLKGTGTAEAVADIKLSSAGWVAVTAHAEEELLLRAYTPRGTTVVVREPPLLPYISSIRGARIPGTAAYRTKKPPSLVENLKAVRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TEP3</accession>
    <name>A0A8C2TEP3_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">VPS50 subunit of EARP/GARPII complex</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">VPS50</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TEP3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005016624.1">
        <property type="protein sequence ID" value="ENSCJPP00005011375.1"/>
        <property type="gene ID" value="ENSCJPG00005009737.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000003442"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990745">
        <property type="term" value="C:EARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019514">
        <property type="entry name" value="Syndetin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040047">
        <property type="entry name" value="VPS50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019515">
        <property type="entry name" value="VPS54_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13258">
        <property type="entry name" value="SYNDETIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13258:SF0">
        <property type="entry name" value="SYNDETIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10474">
        <property type="entry name" value="Syndetin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10475">
        <property type="entry name" value="Vps54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 54 N-terminal" evidence="7">
        <location>
            <begin position="44"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Syndetin C-terminal" evidence="6">
        <location>
            <begin position="714"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="515"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="575"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005011375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="955" mass="110025" checksum="7716B567C28ED74A" modified="2022-01-19" version="1">KPFPLILSPQTLLKSLSLSFLQLPEELRESWEEPTDPQAQQEIINSIEEVYFSNDTFDIVKYELERLPPVLSLQELEEHRDKLKQQQAAVSKKVADLILEKQPAYVQELERVTSLQNGLQLAAVICTDGRRHLNIAKEGFTQTSLGLLANQRKRQLLIGLLKSLRTIKTLQRTDVRLSEMLEEEDYPGAIQLCLECQKAASTFKHYSCISELNSKLQDTLEQIEEQLDVALSKICKNFDINHYTKVQQAYRLLGKTQTAMDQLHMHFTQAIHNTVFQVVLGYVELCAGNTDTKFQKLQYKDLCTHITSDSYIPCLADLCKALWEVMLSYYRTMQWHENHDQDEAATVSSDGSSVVGTEENSFDRSYVKKKLEHGLSRIWQDVQLKVKTYLLGTDLSNFKYDDFIFVLDVISRLMQVGEEFCGSKSEVLQESIRKQSVNYFKTYHRTRLEELRMFLENETWELCPVKSSFHILQLHEFKFMVQSRSPSVSPSKQPASAISTAVTLFEQYCNGGNPFEIQADSKDDETEDVLASNGYESDEQEKSAYQEYDSDSDVPEELKRDYVDEQTGDAPMKSVSRETLKSKKKSDYSLNKGNAPILTNTTLNVVRLVGKYMQMMNILKPIAFDVIHFMSQLFDYYLYAVYTFFGRNDTFELTGLGLSSSRLRTTLNRIQESLIDLEVSADPTGTLTAAEERKEKVPSPHLSHLVVLTSGNSLYGLAERVVATESLVFLAEQFECLQPHLDAVMPAAKKPFLQQFYSQTVSTANELRKPVYWIVAAKAIDYEQMLLLMANVKWDVKEIMSQHNVYVDSLLKEFEEFNRRLNEVSKRVRVPLVVSNILWEHCIRLANRTLVEGYANVKKCSNEGRALMQLDFQQFLMKLEKLTDIRPIPDKEFVETYIKAYYLTENDMERWIKEHREYSTKHLTNLVNVCLGSHINKKARQKLLAAIDDIDRPKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TEV5</accession>
    <name>A0A8C2TEV5_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Apoptosis inhibitor 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">API5</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the API5 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015719961.1">
        <property type="nucleotide sequence ID" value="XM_015864475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TEV5"/>
    <dbReference type="SMR" id="A0A8C2TEV5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005018377.1">
        <property type="protein sequence ID" value="ENSCJPP00005012714.1"/>
        <property type="gene ID" value="ENSCJPG00005010812.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107314805"/>
    <dbReference type="KEGG" id="cjo:107314805"/>
    <dbReference type="CTD" id="8539"/>
    <dbReference type="GeneTree" id="ENSGT00390000010991"/>
    <dbReference type="OrthoDB" id="19224at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017134">
        <property type="term" value="F:fibroblast growth factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044346">
        <property type="term" value="P:fibroblast apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000270">
        <property type="term" value="P:negative regulation of fibroblast apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000092">
        <property type="entry name" value="apoptosis inhibitor 5 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008383">
        <property type="entry name" value="API5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12758:SF19">
        <property type="entry name" value="APOPTOSIS INHIBITOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12758">
        <property type="entry name" value="APOPTOSIS INHIBITOR 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05918">
        <property type="entry name" value="API5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="446"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="460"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="487"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="502"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005012714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="523" mass="58609" checksum="976156E4AFFB8ABC" modified="2022-01-19" version="1">MPTVEELYRNYGILADATETAGQHKDAYQVILDGVKGGAKEKRLAAQFIPKFFKHFPELADSAINAQLDLCEDEDVSIRRQAIKELPQFATGDNLPRVADILTQLLQSDDSAEFNLVNNALLSIFKMDAKGTLGGLFSQILQGEDIVRERAIKFLSTKLKTLPEEVLTKEVEEFILAESKKVLEDVTGEEFVLFMKILSGLKSLQTVSGRQQLVELVAEQADLEQTFNPSDPDCVDRLLQCTRQAVPLFSKNVHSTKFVTYFCEHVLPNLSALTTPVEGLDIQLEVLKLLAEMSSFCGDMEKLESNLKKLFDKLLEYMPLPPEEAENGENAGGEEPKLQFSYVECLLYSFHQLGRKLPDFLTAKLNAEKLKDFKIRLQYFARGLQVYIRQLRLALQGKTGEALKTEENKIKVVALKITNNINVLIKDLFHIPPSYKSTVTLSWKPVQKADANQKRTSEDTTSSSPPKKASAGPKRDARQIYNPPSGKYSSNLGSFSYEQRGGFRGGRGRGWGGRGNRSRGRIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TF69</accession>
    <name>A0A8C2TF69_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Dual specificity protein phosphatase</fullName>
            <ecNumber evidence="9">3.1.3.16</ecNumber>
            <ecNumber evidence="9">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">DUSP13A</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="9"/>
    <dbReference type="EC" id="3.1.3.48" evidence="9"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2TF69"/>
    <dbReference type="Ensembl" id="ENSCJPT00005018554.1">
        <property type="protein sequence ID" value="ENSCJPP00005012851.1"/>
        <property type="gene ID" value="ENSCJPG00005010905.1"/>
    </dbReference>
    <dbReference type="KEGG" id="cjo:107315833"/>
    <dbReference type="GeneTree" id="ENSGT00940000162682"/>
    <dbReference type="OrthoDB" id="426001at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033549">
        <property type="term" value="F:MAP kinase phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008138">
        <property type="term" value="F:protein tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14580">
        <property type="entry name" value="DUSP13A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000037">
        <property type="entry name" value="dual specificity protein phosphatase 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020405">
        <property type="entry name" value="Atypical_DUSP_subfamA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45682">
        <property type="entry name" value="AGAP008228-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45682:SF3">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01908">
        <property type="entry name" value="ADSPHPHTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01909">
        <property type="entry name" value="ADSPHPHTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="10">
        <location>
            <begin position="40"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="11">
        <location>
            <begin position="109"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="8">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR620405-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005012851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="192" mass="21272" checksum="EB9592D39D1E110B" modified="2022-01-19" version="1">MSGEEVLGPLDSSGPGTCMEDVPSLKELEQLLNTGRPSCNHVDEVWPNLFLGDLVTAHNRFILWKMGVTHVLNAAHGTVYSQGGQDFYGATIDYYGVPAYDLPSFDISQFFFSAAEFIHKALNTPGAKILVHCAVGVSRSASLVLAYLMINHHLPLVEAIKTVKEHRWISPNRGFLKHLRNLDVQLRQKKGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TGQ2</accession>
    <name>A0A8C2TGQ2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protein argonaute-2</fullName>
            <shortName evidence="12">Argonaute2</shortName>
            <ecNumber evidence="12">3.1.26.n2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Eukaryotic translation initiation factor 2C 2</fullName>
            <shortName evidence="12">eIF-2C 2</shortName>
            <shortName evidence="12">eIF2C 2</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Protein slicer</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12 16" type="primary">AGO2</name>
        <name evidence="12" type="synonym">EIF2C2</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Required for RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC). The 'minimal RISC' appears to include ago2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the mRNA specifically by ago2. Binding of RISC to a partially complementary mRNA results in silencing through inhibition of translation, and this is independent of endonuclease activity. The inhibition of translational initiation leads to the accumulation of the affected mRNA in cytoplasmic processing bodies (P-bodies), where mRNA degradation may subsequently occur.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.n2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the RISC loading complex (RLC), or micro-RNA (miRNA) loading complex (miRLC), which is composed of dicer1, ago2 and tarbp2. Note that the trimeric RLC/miRLC is also referred to as RISC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cytoplasm</location>
            <location evidence="1 12">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The Piwi domain may perform RNA cleavage by a mechanism similar to that of RNase H. However, while RNase H utilizes a triad of Asp-Asp-Glu (DDE) for metal ion coordination, this protein appears to utilize a triad of Asp-Asp-His (DDH).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the argonaute family. Ago subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.n2" evidence="12"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2TGQ2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005017769.1">
        <property type="protein sequence ID" value="ENSCJPP00005012239.1"/>
        <property type="gene ID" value="ENSCJPG00005010107.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155239"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070062">
        <property type="term" value="C:extracellular exosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098794">
        <property type="term" value="C:postsynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016442">
        <property type="term" value="C:RISC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070578">
        <property type="term" value="C:RISC-loading complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001046">
        <property type="term" value="F:core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090624">
        <property type="term" value="F:endoribonuclease activity, cleaving miRNA-paired mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070551">
        <property type="term" value="F:endoribonuclease activity, cleaving siRNA-paired mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035198">
        <property type="term" value="F:miRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098808">
        <property type="term" value="F:mRNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035197">
        <property type="term" value="F:siRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010586">
        <property type="term" value="P:miRNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035278">
        <property type="term" value="P:miRNA-mediated gene silencing by inhibition of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045947">
        <property type="term" value="P:negative regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045766">
        <property type="term" value="P:positive regulation of angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900153">
        <property type="term" value="P:positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060213">
        <property type="term" value="P:positive regulation of nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031054">
        <property type="term" value="P:pre-miRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090128">
        <property type="term" value="P:regulation of synapse maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070922">
        <property type="term" value="P:RISC complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043489">
        <property type="term" value="P:RNA stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090625">
        <property type="term" value="P:siRNA-mediated gene silencing by mRNA destabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04657">
        <property type="entry name" value="Piwi_ago-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.260.10:FF:000001">
        <property type="entry name" value="Protein argonaute-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000001">
        <property type="entry name" value="Protein argonaute-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000005">
        <property type="entry name" value="Protein argonaute-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03031">
        <property type="entry name" value="AGO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028602">
        <property type="entry name" value="AGO2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014811">
        <property type="entry name" value="ArgoL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032472">
        <property type="entry name" value="ArgoL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032473">
        <property type="entry name" value="Argonaute_Mid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032474">
        <property type="entry name" value="Argonaute_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045246">
        <property type="entry name" value="Piwi_ago-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08699">
        <property type="entry name" value="ArgoL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16488">
        <property type="entry name" value="ArgoL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16487">
        <property type="entry name" value="ArgoMid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16486">
        <property type="entry name" value="ArgoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01163">
        <property type="entry name" value="DUF1785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00949">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 12" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 12" id="KW-0540">Nuclease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 12" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="9 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10 12" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="8 12" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="PAZ" evidence="14">
        <location>
            <begin position="250"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Piwi" evidence="15">
        <location>
            <begin position="538"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="843"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="618"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="690"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="828"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005012239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="880" mass="99745" checksum="8DB126414BD17D87" modified="2022-01-19" version="1">MQFRKQTSQWSLDCLQARHVKSSAAGGTQLLAPPPPLPPPVQGYAFKPPPRPDFGTSGRTIKLQANFFEMDIPKIDIYHYELDIKPEKCPRRVNREIVEHMVQHFKTQIFGDRKPVFDGRKNLYTAMPLPIGRDKLEVTLPGEGKDRIFKVAIKWMSCVSLQALHDALSGRLPSVPFETIQALDVVMRHLPSMRYTPVGRSFFTASEGCSNPLGGGREVWFGFHQSVRPSLWKMMLNIDVSATAFYKAQPVIEFVCEVLDFKSIEEQQKPLTDSQRVKFTKEIKGLKVEITHCGQMKRKYRVCNVTRRPASHQTFPLQQENGQTVECTVAQYFKDRHKLVLRYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIRATARSAPDRQEEISKLMRSASFNTDPYVREFGIMVKDEMTDVTGRVLQPPSILYGGRNKAIATPVQGVWDMRNKQFHTGIEIKVWAIACFAPQRQCTEVHLKTFTDQLRKISKDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAEVKRVGDTLLGMATQCVQMKNVQRTTPQTLSNLCLKINVKLGGVNNILLPQGRPPVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDAHPNRYCATVRVQQHRQEIIQDLAAMVRELLIQFYKSTRFKPTRIIFYRDGVSEGQFQQVLHHELLAIREACIKLEKDYQPGITFIVVQKRHHTRLFCTDKNERVGKSGNIPAGTTVDTKITHPSEFDFYLCSHAGIQGTSRPSHYHVLWDDNRFTADELQILTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVDKEHDSAEGSHVSGQSNGRDPQALAKAVQIHQDTLRTMYFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TGS1</accession>
    <name>A0A8C2TGS1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AT-rich interactive domain-containing protein 3</fullName>
            <shortName evidence="7">ARID domain-containing protein</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ARID3A</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Transcription factor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TGS1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005017795.1">
        <property type="protein sequence ID" value="ENSCJPP00005012263.1"/>
        <property type="gene ID" value="ENSCJPG00005010441.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160899"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd16878">
        <property type="entry name" value="ARID_ARID3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.60:FF:000006">
        <property type="entry name" value="AT-rich interactive domain-containing protein 3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045147">
        <property type="entry name" value="ARI3A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023334">
        <property type="entry name" value="REKLES_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15348:SF1">
        <property type="entry name" value="AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15348">
        <property type="entry name" value="AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN ARID DOMAIN- CONTAINING PROTEIN DEAD RINGER PROTEIN B-CELL REGULATOR OF IGH TRANSCRIPTION BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51486">
        <property type="entry name" value="REKLES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ARID" evidence="9">
        <location>
            <begin position="260"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="REKLES" evidence="10">
        <location>
            <begin position="461"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="11"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="134"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU369100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005012263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="658" mass="71807" checksum="D821228187961DEA" modified="2022-01-19" version="1">MKLQAVMENLQRQQRARLQQALEARQQEQQQQQQQQQRSTPPPAQPSPATGQTPARGRGSDLPPAPMEEGTEPESAHIQRAQMAALAAMRAAAAGLSHSSSPGLSEESQEEEEEEHGEEEEEEEDGGGYQQEMGSEEEEDLKGKWDEEEFEEDLGEEEEEEEEEEEEEEEEEDYEEEEDMGEEGLGSAETVRTGTGSLLLRKPPAPQHCRGEAQRLQGAQERLPAGLGPQGHSQLPQPAPDHGDWTYEEQFKQLYELDGDPRRKEFLDDLFSFMQKRGTPVNRIPIMAKQVLDLYMLYMLVTEKGGLVEVINKKIWREITKGLNLPTSITSAAFTLRTQYMKYLYPYECEKRGLSNPNELQAAIDSNRREGRRQGFGSSLFTYSPGGTHGLLSSPKLPVPALGLASATNGGAIAPVQKIKKEEDAPIPISMPSRLPVSLAGHPVVAAQAAAVQVAAAAQAVALEQLREKLESGEPPEKKMALVTDEQQRLMQRALQQNLLAMTAQLPMSIRINSQGTRSPGGCCCVGIRVGSGHGDFIKVHHLLFLLQRTARTPPAAQPTTAPTASACRLRSTVSSIQVRHGAVLFQVWYHPIFPYRRVPGAPSPALLSPQVCCSPRRPALPPPPPHPPPPTAKAMAAAAAPVAMAPTAVGRGAVGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TGZ6</accession>
    <name>A0A8C2TGZ6_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Ubiquitin conjugating enzyme E2 I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">UBE2I</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015732057.1">
        <property type="nucleotide sequence ID" value="XM_015876571.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015732058.1">
        <property type="nucleotide sequence ID" value="XM_015876572.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015732059.1">
        <property type="nucleotide sequence ID" value="XM_015876573.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TGZ6"/>
    <dbReference type="SMR" id="A0A8C2TGZ6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005017480.1">
        <property type="protein sequence ID" value="ENSCJPP00005012020.1"/>
        <property type="gene ID" value="ENSCJPG00005010256.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107320592"/>
    <dbReference type="KEGG" id="cjo:107320592"/>
    <dbReference type="CTD" id="7329"/>
    <dbReference type="GeneTree" id="ENSGT00550000075088"/>
    <dbReference type="OrthoDB" id="6600758at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016605">
        <property type="term" value="C:PML body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099524">
        <property type="term" value="C:postsynaptic cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099523">
        <property type="term" value="C:presynaptic cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098685">
        <property type="term" value="C:Schaffer collateral - CA1 synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106068">
        <property type="term" value="C:SUMO ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043398">
        <property type="term" value="F:HLH domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071535">
        <property type="term" value="F:RING-like zinc finger domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044388">
        <property type="term" value="F:small protein activating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061656">
        <property type="term" value="F:SUMO conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001221">
        <property type="term" value="F:transcription coregulator binding"/>
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    </dbReference>
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        <location>
            <begin position="4"/>
            <end position="157"/>
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        <location>
            <position position="93"/>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU362109"/>
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            <dbReference type="PROSITE" id="PS50127"/>
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        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005012020.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
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    </evidence>
    <sequence length="158" mass="18007" checksum="E2C826E9C8D0683D" modified="2022-01-19" version="1">MSGIALSRLAQERKAWRKDHPFGFVAVPTKNPDGTMNLMNWECAIPGKKGTPWEGGLFKLRMLFKDDYPSSPPKCKFEPPLFHPNVYPSGTVCLSILEEDKDWRPAITIKQILLGIQELLNEPNIQDPAQAEAYTIYCQNRVEYEKRVRAQAKKFAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TH95</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
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            <taxon>Vertebrata</taxon>
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            <taxon>Archelosauria</taxon>
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            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
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        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
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                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
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                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="protein sequence ID" value="ENSCJPP00005013763.1"/>
        <property type="gene ID" value="ENSCJPG00005011566.1"/>
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        <property type="component" value="Chromosome 3"/>
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        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005013763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="125" mass="14223" checksum="1CEDD566377E5BDF" modified="2022-01-19" version="1">MEAIFSAADIGFKGSLVCYFESFIDRLTIFLVSIPKEHKSFLLLWEPPHWYRSPYASWISCSSVHTSVSSVAACFSPASSKSFKEIISFSISTTGMEGKQTSNIRSRRHNNVVYIKEKDIYMDFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TI96</accession>
    <name>A0A8C2TI96_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">PHD finger protein 12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">PHD factor 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">PHF12</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="13">Component of SIN3 complexes. Interacts with SIN3A in a complex composed of HDAC1, SAP30 and SIN3A. Component of the SIN3B complex, which includes SIN3B, HDAC2 or HDAC1, PHF12 and MORF4L1; interacts directly with all subunits. Interacts with TLE5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_015880734.2"/>
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        <property type="protein sequence ID" value="ENSCJPP00005014225.1"/>
        <property type="gene ID" value="ENSCJPG00005011880.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107322575"/>
    <dbReference type="KEGG" id="cjo:107322575"/>
    <dbReference type="CTD" id="57649"/>
    <dbReference type="GeneTree" id="ENSGT00940000155713"/>
    <dbReference type="OrthoDB" id="1919692at2759"/>
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        <property type="component" value="Chromosome 19"/>
    </dbReference>
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        <property type="term" value="C:Sin3-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017053">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001222">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd22703">
        <property type="entry name" value="FHA_PHF12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15533">
        <property type="entry name" value="PHD1_PHF12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15534">
        <property type="entry name" value="PHD2_PHF12_Rco1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000154">
        <property type="entry name" value="PHD finger protein 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000164">
        <property type="entry name" value="PHD finger protein 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.60">
        <property type="entry name" value="PHD finger protein 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042163">
        <property type="entry name" value="PHF12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031966">
        <property type="entry name" value="PHF12_MRG-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038098">
        <property type="entry name" value="PHF12_MRG-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46309">
        <property type="entry name" value="PHD FINGER PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46309:SF1">
        <property type="entry name" value="PHD FINGER PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16737">
        <property type="entry name" value="PHF12_MRG_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="19">
        <location>
            <begin position="56"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="19">
        <location>
            <begin position="269"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="18">
        <location>
            <begin position="821"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="28"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="110"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="163"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00065785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00068755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00076589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005014225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1011" mass="110283" checksum="584D38C029FB522E" modified="2022-01-19" version="1">MWEKMETKTIVYDLDTSGGLMEQIQALLAPPKSEDGEKRSRRPEKEPRRSGRATNHDSCDSCKEGGDLLCCDHCPAAFHLQCCNPPLSEEMLPPGEWMCHRCTVRRKKREQKKELGQVNGLVDKSGKRTTSPTSDADLLDRSSSSIRANAHARILERRASRPGTPTSNASTETPNSEQNDVDEDIIDVDDDSAIAEMDCGQPQLKRPFELLIAAAMERNPTQFQLPNELTCTTALPGTSKRRRKEETTGKNVKKAQHELDHNGLVPLPVKVCFTCNRSCRVAPLIQCDYCPLLFHMDCLEPPLTAMPLGRWMCPNHIEHVVLNQKNLTLSNRCRVFDRFQDTISQHVVKVDFLNRIHKKHPPNRRVLQSVKRKGLKVPDAIKSQYRLPPPLLAPAAIRDGELICNGIPEEPLQKHLLNTEHLASQTEQQEWLCSVVALQCSILKHLSAKQMTSLWDSEQTEKADIKPVIVADGALANPYQAADKAPTPSLYSMSSCTSGITTQNSLSSSQSQQTLTQEDVNCSSCLDKPKKVSSCGTSNGPTASDIKVNGPHFYGVSSEPSAQLTDSQRLIGAGNNTIPVLSHRQTWPRPLTPPATCGLLNHTIGTIVKTENVGGPVSCAQRGSVPVTSMPTSISSSCASLETTSTLQRKNVQTQIGPPLSADLRSMGSPLTATRALTPPQAAGDGISAVGSTNRFCSPAPPSDGKVSPSTLSIGSALTLPSSLTSNSAAMLDLTSSLKAFMDGEIEINMLDEQLIKFLALQRIHQLFPSKAQSLASSVSAHQQSPVANHIEAQRKEVQARAVFYPLMGLGGAVNMCYRTLYIGTGADMDVCLTSYGHCNYVSGKHACIFYDENTKHYELLNYSEHGTTVDNVLYSCDFSEKMAPTPPSSIVAKVQSVIKRHKSRKQEEEQHEEAAVMNSQAQGQHRKPCNCKASSSSLIGGSGAGWEGTALLHHGSYIKLGCLQFVFSITEFATKQPKGGDAALVQDMDLEDKLSLKPHQVPVLRSNSVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TKQ1</accession>
    <name>A0A8C2TKQ1_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Pleckstrin and Sec7 domain containing 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">PSD3</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Ruffle membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TKQ1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005021339.1">
        <property type="protein sequence ID" value="ENSCJPP00005015014.1"/>
        <property type="gene ID" value="ENSCJPG00005012376.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156591"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome Z"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032587">
        <property type="term" value="C:ruffle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13295">
        <property type="entry name" value="PH_EFA6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1000.11:FF:000004">
        <property type="entry name" value="PH and SEC7 domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000054">
        <property type="entry name" value="PH and SEC7 domain-containing protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041681">
        <property type="entry name" value="PH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF337">
        <property type="entry name" value="PH AND SEC7 DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15410">
        <property type="entry name" value="PH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="9">
        <location>
            <begin position="536"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="8">
        <location>
            <begin position="777"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="76"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="165"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="732"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="990"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="732"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="751"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1003"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1020"/>
            <end position="1029"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1039" mass="116011" checksum="0258263E46DB50ED" modified="2022-01-19" version="1">MERFSVLLGALKGEEALVWDNDISAHAQSVAKAKYEFLFGLEEEKPSEVGSGHGSNTLLPHTIINEFPEYGTMEASRDALRTPSKSQAEPVTCSPEGRDHHHISDRPPQSVASADEPRAQVKATHLHTAEEGLQPVGNLPEKMKISRQLEATKVQERANTSLDSEMHMEKKSVPGRQNVQTAREPVATGQEKPSDMPLPSERTAEEKMHLIIEKDLAATWTGEKQSESLQATSNNAEEVRTAEEMSCCRPSVTNLEAASRVEGWEHSEEFSAYSQGKTQMGPERRFSKEAAVSKHVEFQGVEILWLQKAEDQNRKKHSLLETTSVDRKAFPKTSSHSVPLMVGPSLVTLPDSAKSEVWEEPRVGTAHGAAPLALLDESGEDEVFVKDKKNHSKEETTVGNEEVFSEGEAAMGGYEDVLGQRQSDVSTDLYSSQFENILDNASLYYSVESLETLYSEPDSYFSFEMPLTPMIQQRMKEGSQFLERTSASGQMDVFELPPDGEEKSCCEGIANGLRNVSETLFRGDVTEVPHLGSDAGLQNMVLDSSAAMGSNKVQEEDAAGALGHDLSNGSSSNLEAARHLAKRLYHLDRFKRSDVAKHLGKNNEFSKLVAEEYLKFFDFTGMTLDFSLRYIFFKAFSLIGETQERERVLVHFSSRYYQCNPNTISSKDGVHCLTCALMLLNTDLHGHNIGKKMTCQEFIANLQGMNDGKDFQKGLLKALYNSIKNEKLEWAVDEEEKKKPHSDGTDEKDNGNQTKTVSRIGNSNNPFLDIPHDPNAAVYKTGFLARKIHADMDGKKTPWGKRGWKTFYAVLKGTVLYLQKDEYKPEKALSEEDLKNAVSVHHALASKATDYEKKPNVLKLKTADWRVLLFQAQSQEEMQTWINKINCVAAVFSAPPFPAAIGSQKKFSRPLLPATTTKLSQDEQLKSHEAKLKQISTELAEHRSYPPDKKLKGKEVDDYKLKDHYLEFEKNRYEIYIGLLKEGVKELLSGGENDASGLKKSHSSTSLNQESPVSAKVKRSVSERKDYRPETPSIKQKVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TL79</accession>
    <name>A0A8C2TL79_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">U4/U6.U5 tri-snRNP-associated protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">SNRNP27</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May play a role in mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of a tri-snRNP complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SNUT3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TL79"/>
    <dbReference type="Ensembl" id="ENSCJPT00005020013.1">
        <property type="protein sequence ID" value="ENSCJPP00005013993.1"/>
        <property type="gene ID" value="ENSCJPG00005011739.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00730000111237"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013957">
        <property type="entry name" value="SNRNP27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31077">
        <property type="entry name" value="U4/U6.U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 27 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31077:SF1">
        <property type="entry name" value="U4_U6.U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 27 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08648">
        <property type="entry name" value="SNRNP27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="U4/U6.U5 small nuclear ribonucleoprotein 27kDa protein" evidence="11">
        <location>
            <begin position="90"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005013993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="147" mass="17529" checksum="37083492239E17ED" modified="2022-01-19" version="1">LHHPHPHVPLPSDRRRSRSASRDRDRRRRERTRSRDRDRRRTRSRSPHRRRSRSGARYRYLRSLYLRSLLSPSPFPSPTPFPEDLQGKTEEEIEMMKMMGFASFDTTKGKKVDGAANAYAINVSQKRKYRQYMNRKGGFNRPLDFIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TLP7</accession>
    <name>A0A8C2TLP7_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Aryl hydrocarbon receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC107316403</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015723306.1">
        <property type="nucleotide sequence ID" value="XM_015867820.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TLP7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005021871.1">
        <property type="protein sequence ID" value="ENSCJPP00005015422.1"/>
        <property type="gene ID" value="ENSCJPG00005012785.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107316403"/>
    <dbReference type="KEGG" id="cjo:107316403"/>
    <dbReference type="GeneTree" id="ENSGT00940000154486"/>
    <dbReference type="OrthoDB" id="6099906at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034751">
        <property type="term" value="C:aryl hydrocarbon receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004879">
        <property type="term" value="F:nuclear receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000035">
        <property type="entry name" value="Aryl hydrocarbon receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000019">
        <property type="entry name" value="Aryl hydrocarbon receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039091">
        <property type="entry name" value="AHR/AHRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10649">
        <property type="entry name" value="ARYL HYDROCARBON RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10649:SF18">
        <property type="entry name" value="ARYL HYDROCARBON RECEPTOR 1 BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="10">
        <location>
            <begin position="17"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="9">
        <location>
            <begin position="108"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="607"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="902"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="958" mass="105066" checksum="DC1F5911C105154E" modified="2022-01-19" version="1">MYAGRKRRKPAARALRPADSGRSNPSKRHRERLNRELERLAALLPFPEEVSAGLDKLSILRLSAAFLRAKSFFRVALKNHSAEGAERDGGGDSSPALGMAAVPEGELLLQALNGFVLVVTSEGLILYSSHTIQDYLGFHQTDVMHQSIFKLIHTEDHQEFRRNLHWALNLPLTPEGEPSPEGRKSLSSPAVAYRPDQLPLENFSFLERSFVCRFRCLLDNSSGFLALNLQGRLRFLHGQNKRSEDGSVLPPQLALFAISTPLQPPSILEIRTKNMIFRTKHKLDFTPLACDAKGKIVLGYTEAELRMCGTGYQFIHAADMLYCAENHIRMMKTGESGLTVFRLLTKDKHWKWVQANARLVYKNSKPEYIIVTQRPLVDEEGGEHLRKRSMHLPFTFATGEALLYQSAFPFPGFCDAFHSKGKISKSRRTSHSNEGCSQKDSIAPGSLLSAVLQQDKAAYAPHPAPSANHTFSSSFSYHPENTSSLGAGQAWSTSAAPVPSRKDSLTEEWVDLQQEDPLLTTLNSLTINSDESCSNDELFSALESLGLNTEDLELLLLDEKMVMVNTDPDHTLSLSDFLTNNEILSYIQTMLGNKSKEGLQACPAPGMTSSTAGGSAAYQGHAEDKDSQYPLQQTQQPGAVTGQAAALLWEHPLHDALAQLSPLPSKPMEAELELPAGLQCRPAGEEGILHFLQLTQVTPWAVAPSSHLGTPYPLEAQQLESYFPAVHPTQQDILQTFSLPSQRRVHGAAPSQLKHKAGRRLLMNRLCPHHHPSAPRFLPTSSSSPWQDYVSPLLTSSAQPDFYGISQDLISQHQGYLGPVPGPAVPAVDSNPNGLCSMDTVDSERSQDGLFPSSSYQLIPEMHPSSVPSMYPFLSSSAEYFGSTDSVLEASGNSHGVYTSMMSQESSHKPDGSCVLPGSHMGLPADVPKGSTASPCKLHPHAEVLPDHPHAFSGDFYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TLZ7</accession>
    <name>A0A8C2TLZ7_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Solute carrier family 23 member 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">SLC23A3</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TLZ7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005022440.1">
        <property type="protein sequence ID" value="ENSCJPP00005015887.1"/>
        <property type="gene ID" value="ENSCJPG00005013118.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182953"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035344">
        <property type="term" value="P:hypoxanthine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11119">
        <property type="entry name" value="XANTHINE-URACIL / VITAMIN C PERMEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="422"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="452"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="484"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="519"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="599"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="624" mass="66008" checksum="CF54676C45634E40" modified="2022-01-19" version="1">MRGGSSMNGGRHPVTGAGSPALTSCSWPKMCSWMLSCCLALQHLAVQASLLCIFHLLLLPALSEEQLHAPAASVLLARSLFACGISTLLQTTLGSRLPLVQIPSFEYLVPALVLSSHLSLGVSEDENGMAVATMCPEPHCTITESRAASLQEVSGAVLISGLVQLVLGAVGVCGWAVQRCGPMVLAPSLSIIGLSAYKEAAFFCSANWGVALLLMLFTITFSQHLGSCRLPFCAWPYVPGVSMEPSVPTLRTLSVLLPFAIVCTICSIIHHFHVSWDLPDLATAQLSWVNSTLHTPWLQLPYAGEWPLLTPRALAVGIAMAFGCSINSVGCYVLCGKLLRAPQLPPHTCNRGLCIEGLGSLLAGLLGSAGGTAASIANACAGGLTQDGSRLSVQLNALACVMLGMSPRLVGLLAYIPLAVHGGVLCVTYAVAVGMGISYFQYADIDSGRNIFIVGFTMFMALLVPRWLSVAPAHLVTGWVPLDLLFLSLLVMPVFLTGFLSFFLENTVSGTLEERGMLADSVQRKPGTSSGQPWRKGSKTSPVYGLPTWLRRLLPSSCKAFPCCFLCPVSEDEKEEEEDGGLVAEEGTAAVGEGTHLLLKPGTGEMRADRRPSQAEMLTSHTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TM71</accession>
    <name>A0A8C2TM71_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Coiled-coil domain containing 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CCDC6</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TM71"/>
    <dbReference type="Ensembl" id="ENSCJPT00005022530.1">
        <property type="protein sequence ID" value="ENSCJPP00005015973.1"/>
        <property type="gene ID" value="ENSCJPG00005013173.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000013594"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019152">
        <property type="entry name" value="DUF2046"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15276:SF0">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15276">
        <property type="entry name" value="H4 D10S170 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09755">
        <property type="entry name" value="DUF2046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="439"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="493"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="153"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="359"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="448"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="523"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="552"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="570" mass="62159" checksum="8722C76487F3E868" modified="2022-01-19" version="1">MFQSALMPDSKVRSDGSPRCCGAPHRAPLGRSARGIPPGPPPMLALRRAAPPGGAVAGGSSGGRSRRSGRRRSAAGAAPCSPGGAAAAGAAAMADSASESDTDGAGGSGGGGSAAGALAAGGTATAGTGGGGGGSGSAGGGKAGGIVISPFRLEELTNRLASLQQENKVLKIELETYKLKCKALQEENRDLRKASVTIQARAEQEEEFISNTLFKKIQALQKEKETLAVNYEKEEEFLTNELSRKLMQLQHEKAELEQHLEQEQEFQVNKLMKKIKKLENDTISKQLTLEQLRREKIDLENTLEQEQEALVNRLWKRMDKLEAEKRILQEKLDQPVSAPPSPRDISMEIDSPENMMRHIRFLKNEVERLKKQLRAAQLQHSEKMAQYLEEERHMREENLRLQRKLQREMERREALCRQLSESESSLEMDDERYFNEMSAQGLRPRTVSSPIPYTPSPSSSRPISPGLSYASHTVGFTPPTSLTRAGMSYYNSPGLHVQHMGPSHGITRPSPRRSNSPDKFKRPTPPPSPNTQTPVQPPPPPPPPPVQPTVQSAASQSATFQHSVHPSSQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TMC9</accession>
    <name>A0A8C2TMC9_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TLC domain containing 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">TLCD1</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015736539.1">
        <property type="nucleotide sequence ID" value="XM_015881053.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TMC9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005019845.1">
        <property type="protein sequence ID" value="ENSCJPP00005013846.1"/>
        <property type="gene ID" value="ENSCJPG00005011646.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107322724"/>
    <dbReference type="KEGG" id="cjo:107322724"/>
    <dbReference type="CTD" id="116238"/>
    <dbReference type="GeneTree" id="ENSGT01010000222313"/>
    <dbReference type="OrthoDB" id="10266980at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:phospholipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007009">
        <property type="term" value="P:plasma membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097035">
        <property type="term" value="P:regulation of membrane lipid distribution"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050846">
        <property type="entry name" value="TLCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439">
        <property type="entry name" value="CT120 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439:SF5">
        <property type="entry name" value="TLC DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="7">
        <location>
            <begin position="41"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005013846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="252" mass="28288" checksum="AA5F8DC5D5752C18" modified="2022-01-19" version="1">MGPGWRAPSAALVGGSVALFGALRRAALVLPRPAAVRNRPGRVWRWLNLLVSFAHSVLAGLWALFSLWQSPELLSDIQDGYSVSGHLLVCFSSGYFIHDSLDIIFNQQSRSSWEYLVHHAMAISAFVSLIITGRFLVAAMLLLLVEVSNIFLTARMLLKMSNVPSPALYEANKYINLVMYFAFRLAPQAYLTWYFVRYVEVQGQGAFLMANLLLLDAMILMYFSRLLRSDFFPSLRKGAVGRDVDGEKFLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TMF6</accession>
    <name>A0A8C2TMF6_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Interleukin 1 receptor type 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">IL1R2</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the interleukin-1 receptor family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015705745.1">
        <property type="nucleotide sequence ID" value="XM_015850259.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TMF6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005022573.1">
        <property type="protein sequence ID" value="ENSCJPP00005016015.1"/>
        <property type="gene ID" value="ENSCJPG00005013202.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107306854"/>
    <dbReference type="KEGG" id="cjo:107306854"/>
    <dbReference type="CTD" id="7850"/>
    <dbReference type="GeneTree" id="ENSGT01090000259985"/>
    <dbReference type="OrthoDB" id="9881731at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019966">
        <property type="term" value="F:interleukin-1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="entry name" value="INTERLEUKIN-1 RECEPTOR FAMILY MEMBER"/>
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        <property type="entry name" value="INTERLEUKIN-1 RECEPTOR TYPE 2"/>
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        <property type="entry name" value="Ig_6"/>
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        <property type="entry name" value="INTRLEUKN1R2"/>
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    <dbReference type="PRINTS" id="PR01536">
        <property type="entry name" value="INTRLKN1R12F"/>
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        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0393">Immunoglobulin domain</keyword>
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    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
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    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
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    <feature type="domain" description="Ig-like" evidence="14">
        <location>
            <begin position="51"/>
            <end position="147"/>
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    <sequence length="408" mass="47099" checksum="DE78A45C07BD362A" modified="2022-01-19" version="1">MQKHRFQDIFPHSSSHFLWERMHGFFFALVTCTVCASAFKLQQGKSTENCPDHTMFFQYYYELHGEPVVLKCPSPRYKHVDFSALTHNITWYKNDSKTMILGRDEDPRIWAKGDALWFLPARKEDSGVYICTRRNNSYCAEVSIHLTVVQKAAARDIAYPQVLFTFTSGKIICPNLWEFTTNRTNVELQWYKDAQLLEDDSEKFVFLKESSSLFFTSVLPTDSGYYTCKMAFPYEGVTYEITRTIELQTVEQEKRITPIIVYPTQKTTSAALGSKMTLPCKVFAGPNSNIYTDVEWLANDTTIDVVYKQNRVMEGERQEMTENGENFIEVPLIFKSVEEVDFYTDFKCLAQNTYGSQVLPTRVKQEAVGLPWYIATIPVTLACIILMGICVQKRWKQRADKGYTIAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TP06</accession>
    <name>A0A8C2TP06_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Homeobox A5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">HOXA5</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the Antp homeobox family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015709243.1">
        <property type="nucleotide sequence ID" value="XM_015853757.2"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A8C2TP06"/>
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        <property type="protein sequence ID" value="ENSCJPP00005015085.1"/>
        <property type="gene ID" value="ENSCJPG00005012529.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107309184"/>
    <dbReference type="KEGG" id="cjo:107309184"/>
    <dbReference type="CTD" id="3202"/>
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        <property type="component" value="Chromosome 2"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:anterior/posterior pattern specification"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0060435">
        <property type="term" value="P:bronchiole development"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:cell migration"/>
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    </dbReference>
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        <property type="term" value="P:embryonic skeletal system morphogenesis"/>
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        <property type="term" value="P:epithelial tube branching involved in lung morphogenesis"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:positive regulation of myeloid cell differentiation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003016">
        <property type="term" value="P:respiratory system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030878">
        <property type="term" value="P:thyroid gland development"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060535">
        <property type="term" value="P:trachea cartilage morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000055">
        <property type="entry name" value="Homeobox protein Hox-A5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050296">
        <property type="entry name" value="Antp_homeobox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017995">
        <property type="entry name" value="Homeobox_antennapedia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001827">
        <property type="entry name" value="Homeobox_Antennapedia_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45659">
        <property type="entry name" value="HOMEOBOX PROTEIN HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45659:SF10">
        <property type="entry name" value="HOMEOBOX PROTEIN HOX-A5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00025">
        <property type="entry name" value="ANTENNAPEDIA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00032">
        <property type="entry name" value="ANTENNAPEDIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0371">Homeobox</keyword>
    <keyword evidence="8 9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="13">
        <location>
            <begin position="193"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="9">
        <location>
            <begin position="195"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="67"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="74"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="144"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009107"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023155"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="270" mass="29742" checksum="1A9F8EC9E740B1CC" modified="2022-01-19" version="1">MSSYFVNSFCGRYPNGPDYQLHNYGDHSSVSEQYRDSASMHSGRYGYGYNGMDLSVGRSASTHFGASERARTYPANSTSASTEPRYSQSAAASHSPPPDPLPCTAVAASPVSESHHGVKNSLGNSSSTSSNSSSSTHISRDGVGTSSGTEEDTPASSEQASAPSDQSTAQPSQPQIYPWMRKLHISHDNIGGPEGKRARTAYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLSERQIKIWFQNRRMKWKKDNKLKSMSMAAAGGAFRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TPR1</accession>
    <name>A0A8C2TPR1_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Forkhead box O4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">FOXO4</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TPR1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005022501.1">
        <property type="protein sequence ID" value="ENSCJPP00005015945.1"/>
        <property type="gene ID" value="ENSCJPG00005013152.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159334"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140297">
        <property type="term" value="F:DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008286">
        <property type="term" value="P:insulin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016525">
        <property type="term" value="P:negative regulation of angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070317">
        <property type="term" value="P:negative regulation of G0 to G1 transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051151">
        <property type="term" value="P:negative regulation of smooth muscle cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070936">
        <property type="term" value="P:protein K48-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048863">
        <property type="term" value="P:stem cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd20062">
        <property type="entry name" value="FH_FOXO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000032">
        <property type="entry name" value="Forkhead box protein O4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047409">
        <property type="entry name" value="FH_FOXO4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032067">
        <property type="entry name" value="FOXO-TAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032068">
        <property type="entry name" value="FOXO_KIX-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45767">
        <property type="entry name" value="FORKHEAD BOX PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45767:SF3">
        <property type="entry name" value="FORKHEAD BOX PROTEIN O4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16676">
        <property type="entry name" value="FOXO-TAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16675">
        <property type="entry name" value="FOXO_KIX_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="10">
        <location>
            <begin position="98"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="8">
        <location>
            <begin position="98"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="173"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="301"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="522"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="202"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="301"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="318"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="522"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="542" mass="56537" checksum="6DD6156C72181D79" modified="2022-01-19" version="1">MAEAGGAAATAPDIDPDFEPQSRPRSCTWPLPRPELPAGAAEAGGTGGTGAAAEEGAGGAAAAAAAAGPGRAEGARAGGGGGAAAAAARKGGSRRNAWGNLSYADLITQAIESSPEKRLTLSQIYDWMVRCVPYFKDKGDSNSSAGWKNSIRHNLSLHSKFIKVHNEATGKSSWWMLNPEGGKSGKAPRRRAASMDNSSKLAKVRSKASKKKPPLQSAPEATADSPGSQFPKWPGSPSSRSNEDSDVWNTFRLSPILTEQDDLHDEELLPSMVYSSASSNVPPTVTEELELIDGLNLMSPSSSVLSTQQSTSSGQIQRDSSFSLRSPSAAGQTATFGNSLFNPVEMSLQSSVSHFSGPQTLEALLTPGSPPPRDVLMTQVDPVLPQTGGRMSSRTLLLLGGQATQSKMSSGNLRGKPAEQQAEPVGASALPSTLPIVASPQNTASINSLKAPVSATAAQSVQLGSPPLLSSAGPAPLGLNQDRLPIDLDIDMYMENLECDMDYIIRSELMDADGLDFNFEPVPSTPSYPSSSQASSHTWVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TQP7</accession>
    <name>A0A8C2TQP7_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transmembrane protein 184A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TMEM184A</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TQP7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005024170.1">
        <property type="protein sequence ID" value="ENSCJPP00005017323.1"/>
        <property type="gene ID" value="ENSCJPG00005014143.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153861"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="259"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005017323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="460" mass="51743" checksum="F75C35CF811700EC" modified="2022-01-19" version="1">MGRRKAQQRFVGWETCWDLPPHQFTSIPRHSPYLSLPQMSNATRAWPSPVAPSSPGPGTAARLAATTPSTALTLLTAAHNDSQDGQQLFLTTTTARVISGIFVWSALIVTFHQIYMHLKNYTIPKEQRYIIRILFIVPIYAFDSWLSLLLLGSHQYYVYFDSVRDCYEAFVIYSFLSLCFEYLGGESTIMTEIRGKPIASSCLYGTCCLQGMSYSIGFLRFCKQATLQFCIVKPLMAIVTIILQAFGKYHDGDFNVRSGYLYITIIYNFSVSLALYALFLFYFATMDLLRPFEPVLKFLTIKAVIFLSFWQGTLLAILEKFGVIPEVQIIDGKEVGAGTVAAGYQNFIICIEMLFASIALRYAFSCRVYREKKENSTANLAPMQSISSGLKETMSPQDIVQDAIHNFSPTYQQYTQQAMQEAERKAPGENGHVACRAEGAGGRKSKNIEKRVLILSDEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TRU0</accession>
    <name>A0A8C2TRU0_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Epithelial cell transforming 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ECT2</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015727446.1">
        <property type="nucleotide sequence ID" value="XM_015871960.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TRU0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005024366.1">
        <property type="protein sequence ID" value="ENSCJPP00005017488.1"/>
        <property type="gene ID" value="ENSCJPG00005014271.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107318314"/>
    <dbReference type="KEGG" id="cjo:107318314"/>
    <dbReference type="CTD" id="1894"/>
    <dbReference type="GeneTree" id="ENSGT00940000156299"/>
    <dbReference type="OrthoDB" id="9997817at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097149">
        <property type="term" value="C:centralspindlin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032154">
        <property type="term" value="C:cleavage furrow"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070830">
        <property type="term" value="P:bicellular tight junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071277">
        <property type="term" value="P:cellular response to calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070301">
        <property type="term" value="P:cellular response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071479">
        <property type="term" value="P:cellular response to ionizing radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903438">
        <property type="term" value="P:positive regulation of mitotic cytokinetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045666">
        <property type="term" value="P:positive regulation of neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042307">
        <property type="term" value="P:positive regulation of protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051988">
        <property type="term" value="P:regulation of attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000431">
        <property type="term" value="P:regulation of cytokinesis, actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17733">
        <property type="entry name" value="BRCT_Ect2_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17732">
        <property type="entry name" value="BRCT_Ect2_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01229">
        <property type="entry name" value="PH_Ect2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.900.10:FF:000022">
        <property type="entry name" value="protein ECT2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000016">
        <property type="entry name" value="protein ECT2 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026817">
        <property type="entry name" value="Ect2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049396">
        <property type="entry name" value="ECT2_BRCT0"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049395">
        <property type="entry name" value="ECT2_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16777">
        <property type="entry name" value="PROTEIN ECT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16777:SF2">
        <property type="entry name" value="PROTEIN ECT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21243">
        <property type="entry name" value="ECT2_BRCT0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21242">
        <property type="entry name" value="ECT2_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12738">
        <property type="entry name" value="PTCB-BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="3">
        <location>
            <begin position="178"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="3">
        <location>
            <begin position="266"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="452"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005017488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="914" mass="102853" checksum="3DC5284171CED59D" modified="2022-01-19" version="1">MADNSTLVSESGRSLLADSSVLDSKIVENSKENVFPGSVVDVEEEMPQIETRVVLVQEAGKNEELLKALETIRIMEVPVIKIKETSPGKSEEKLIKSIIHMEIKVPYMKTNTIEELGDCDSPEFETVFVVTDFEGSIFNNLCKADCRVIGPPVVLHCAQKGEPLPFSCRPLYCASMLNLVLCFTGFRKKDELVKLVTLVHHMGGIIRKDFNSKVTHLVANSTQGDKFRIAVSLGAPITKAEWICKAWEKRNEIDFCAADDDVRNQFKVPPFQDCLLSFLGFSDEEKASMEEMTEMQGGCYLPVGDERCTHLVVEESTVKEIPFEPLKKLYIVKQEWFWGSIQMDARAGESMYLFEKSESPGLKKSVSQLSLSTPNSNRKRRRLKETLAQLTRETDMSPFPPRKRPSAEHSLSLGSLLDISNTPESSTTNGETPKSCARPSRNSTPLPLKQSARWQVAKELYQTESNYVDILTTIIQLFQVPLEKEGQLGGPILAQEEIKTIFGSIPDILDVHTKIKEDLEDLMVNWTESKSIGDIFLKYSKDLLKTYPPFVNFFEMSKETITRCEKQKPRFHAFLKINQAKPECGRQSLAELLIRPVQRLPSVVLLLNDLKKHTAEDNPDKIILERAIESLKEVMTHINEDKRKTEAQRQFFDVVYEVDGCPANLLSSHRSLVQRLETVALGDDICDRGEQVTLFLFNDCLEIARKRHKVIGAFKSPHGHTRPPASLKHVVLMPLSQIKKVLDIRETEDCHKAFALVVRPPTEHNNKLLSFQMTSEEPPKEDWLKTLCRHVANTICKADAENLIYAADPDSVEVNTKDMDSTLSRASRAIKKTSKKVTRAFSFSKTPKRALRRALMSHSATEGRSPSSANESYIGSRLTSTSSLAGISSPSLVSLPSIFEKRSHTLSRSTTHLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TSD6</accession>
    <name>A0A8C2TSD6_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane protein 238</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TSD6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005023067.1">
        <property type="protein sequence ID" value="ENSCJPP00005016395.1"/>
        <property type="gene ID" value="ENSCJPG00005013480.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162720"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029365">
        <property type="entry name" value="TMEM238"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28613">
        <property type="entry name" value="SI:CH211-232M10.4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28613:SF9">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 238"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15125">
        <property type="entry name" value="TMEM238"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005016395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="197" mass="20663" checksum="8FC92B46C8892313" modified="2022-01-19" version="1">VPFWAEVSASQGKKPHVRSHRAAANMAAPGGLGRCVVAFWLALAFDAVGLAVLLAGVFADVFFADLLIYAGGIGIFLSLIWWVFWYAGNLEVSPEELLDDVGLASPKGRGDSVLRGLVHGFSLRLSSVLGTASRSRRAADLELQRARCPPRHYDGSRQVVRGEGCGSAGGGRSVLPGAGTAGESSTRKLGWGKIGCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TSH5</accession>
    <name>A0A8C2TSH5_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TSH5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005023460.1">
        <property type="protein sequence ID" value="ENSCJPP00005016742.1"/>
        <property type="gene ID" value="ENSCJPG00005013733.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163166"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF134">
        <property type="entry name" value="CYTOCHROME P450, FAMILY 2, SUBFAMILY AB, POLYPEPTIDE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005016742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="187" mass="21433" checksum="36D0F0335FEAD65B" modified="2022-01-19" version="1">MTVGLTDCCAFKADYFFPEKVHKELDAVLGSSRLICYTDRKNLPYTNAVIHEIQRYSNIVLIALPRYTVKDTELLGFRIPKDTIVLVNIDSVLTDPEKWETPDQFNPEHFLDKDGNFVHREAFLPFSIGQRACMGELLARLELFIIFCTLLQSFTFTLPDGVKEINTKFVFSSTMKPPPHQLCAIPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TT87</accession>
    <name>A0A8C2TT87_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ADP-ribosylation factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ARF4</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015730397.1">
        <property type="nucleotide sequence ID" value="XM_015874911.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TT87"/>
    <dbReference type="SMR" id="A0A8C2TT87"/>
    <dbReference type="Ensembl" id="ENSCJPT00005023005.1">
        <property type="protein sequence ID" value="ENSCJPP00005016344.1"/>
        <property type="gene ID" value="ENSCJPG00005013444.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107319778"/>
    <dbReference type="KEGG" id="cjo:107319778"/>
    <dbReference type="CTD" id="378"/>
    <dbReference type="GeneTree" id="ENSGT00940000156297"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043197">
        <property type="term" value="C:dendritic spine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032587">
        <property type="term" value="C:ruffle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005154">
        <property type="term" value="F:epidermal growth factor receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106274">
        <property type="term" value="F:NAD+-protein-arginine ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990583">
        <property type="term" value="F:phospholipase D activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045176">
        <property type="term" value="P:apical protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060996">
        <property type="term" value="P:dendritic spine development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045197">
        <property type="term" value="P:establishment or maintenance of epithelial cell apical/basal polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007612">
        <property type="term" value="P:learning"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061512">
        <property type="term" value="P:protein localization to cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902017">
        <property type="term" value="P:regulation of cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099175">
        <property type="term" value="P:regulation of postsynapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000377">
        <property type="term" value="P:regulation of reactive oxygen species metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd04150">
        <property type="entry name" value="Arf1_5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000024">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045872">
        <property type="entry name" value="Arf1-5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 14" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10 14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 14" id="KW-0519">Myristate</keyword>
    <keyword evidence="5 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU369003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005016344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="180" mass="20529" checksum="8A9D1DA9C9AEF081" modified="2022-01-19" version="1">MGLTISSLFSRLFGKKQMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKNICFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRERIEEAADELQKMLQEDELRDAVLLLFANKQDLPNAMAISEMTDKLGLQSLRNRTWYVQATCATQGTGLYEGLDWLSNELSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TU57</accession>
    <name>A0A8C2TU57_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AP-1 complex subunit mu-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">AP1M1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8 9">Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Cytoplasmic vesicle</location>
            <location evidence="9">Clathrin-coated vesicle membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TU57"/>
    <dbReference type="Ensembl" id="ENSCJPT00005026312.1">
        <property type="protein sequence ID" value="ENSCJPP00005018962.1"/>
        <property type="gene ID" value="ENSCJPG00005015181.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157924"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030665">
        <property type="term" value="C:clathrin-coated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035646">
        <property type="term" value="P:endosome to melanosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032438">
        <property type="term" value="P:melanosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09258">
        <property type="entry name" value="AP-1_Mu1A_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14835">
        <property type="entry name" value="AP1_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1170:FF:000002">
        <property type="entry name" value="AP-1 complex subunit mu-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000006">
        <property type="entry name" value="AP-1 complex subunit mu-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018240">
        <property type="entry name" value="Clathrin_mu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00990">
        <property type="entry name" value="CLAT_ADAPTOR_M_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00991">
        <property type="entry name" value="CLAT_ADAPTOR_M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="10">
        <location>
            <begin position="196"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00057121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005018962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="449" mass="51391" checksum="315C76611DC2A011" modified="2022-01-19" version="1">PLPADHCAYPSARPDLVQPLPTGSGGRKRKSLAVYVLDLKGKVLICRNYRGDVDMSEVEHFMPILMEKEEEGTLSPILAHGGVRFMWIKHNNLYLVATSKKNACVSLVFSFLYKVVQVFSEYFKELEEESIRDNFVIIYELLDELMDFGYPQTTDSKILQEYITQEGHKLETGAPRPPATVTNAVSWRSEGIKYRKNEVFLDVIESVNLLVSANGNVLRSEIVGSIKMRVFLSGMPELRLGLNDKVLFDNTGRDKSVELEDVKFHQCVRLSRFENDRTISFIPPDGEFELMSYRLNTHVKPLIWIESVIEKHSHSRIEYMIKAKSQFKRRSTANNVEIHIPVPNDADSPKFKTTVGSVKWVPENSEIVWSIKSFPGGKEYLMRAHFGLPSVEAEDKEGKPPISVKFEIPYFTTSGIQVRYLKIIEKSGYQALPWVRYITQNGDYQLRTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TU71</accession>
    <name>A0A8C2TU71_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein uL29m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MRPL47</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015727013.1">
        <property type="nucleotide sequence ID" value="XM_015871527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TU71"/>
    <dbReference type="Ensembl" id="ENSCJPT00005024329.1">
        <property type="protein sequence ID" value="ENSCJPP00005017465.1"/>
        <property type="gene ID" value="ENSCJPG00005014249.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107318122"/>
    <dbReference type="KEGG" id="cjo:107318122"/>
    <dbReference type="CTD" id="57129"/>
    <dbReference type="GeneTree" id="ENSGT00390000002837"/>
    <dbReference type="OrthoDB" id="270763at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038340">
        <property type="entry name" value="MRP-L47_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010729">
        <property type="entry name" value="Ribosomal_uL29_mit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21183:SF18">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL29M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21183">
        <property type="entry name" value="RIBOSOMAL PROTEIN L47, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06984">
        <property type="entry name" value="MRP-L47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005017465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="249" mass="29409" checksum="614E2C7D576F85B1" modified="2022-01-19" version="1">MAAATVMAALGRRLAGAMRLSGARQGLGAAGLPGFTLNLCRENLARAEPLRHVRSVQTTLPRKGLEEFFDDPKNWGEKTVKSGDAWDIKQLRAKSSQDLHKLWYVLLKEKNMLLTLEQESKRQQKPMPSPERLEKVEKSMKNIDLVVREREIALRLLQTGHEKPVPGEWRNDFLGRTYWYSYKEWPIPWYLNKKHKRRKFYYLPHVNRFIRLRLEKYLRLRNRRQNLAKKKQKLLEKKFPHLAVKSQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TV87</accession>
    <name>A0A8C2TV87_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13">RNA cytidine acetyltransferase</fullName>
            <ecNumber evidence="13">2.3.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">18S rRNA cytosine acetyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">NAT10</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA-binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a cytidine in 18S rRNA + acetyl-CoA + ATP + H2O = an N(4)-acetylcytidine in 18S rRNA + ADP + phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51424"/>
            <dbReference type="Rhea" id="RHEA-COMP:13575"/>
            <dbReference type="Rhea" id="RHEA-COMP:13576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a cytidine in tRNA + acetyl-CoA + ATP + H2O = an N(4)-acetylcytidine in tRNA + ADP + phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53876"/>
            <dbReference type="Rhea" id="RHEA-COMP:13670"/>
            <dbReference type="Rhea" id="RHEA-COMP:13671"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Interacts with THUMPD1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3. Interacts with THUMPD1. Interacts with SUN1 (via N-terminus). Interacts with TERT.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
            <location evidence="1 13">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="13"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2TV87"/>
    <dbReference type="Ensembl" id="ENSCJPT00005026589.1">
        <property type="protein sequence ID" value="ENSCJPP00005019159.1"/>
        <property type="gene ID" value="ENSCJPG00005015492.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000009140"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005697">
        <property type="term" value="C:telomerase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990883">
        <property type="term" value="F:18S rRNA cytidine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070182">
        <property type="term" value="F:DNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106162">
        <property type="term" value="F:mRNA N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032211">
        <property type="term" value="P:negative regulation of telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010824">
        <property type="term" value="P:regulation of centrosome duplication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904812">
        <property type="term" value="P:rRNA acetylation involved in maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051391">
        <property type="term" value="P:tRNA acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11040:FF:000006">
        <property type="entry name" value="RNA cytidine acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000019">
        <property type="entry name" value="RNA cytidine acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002218">
        <property type="entry name" value="tRNA(Met) cytidine acetyltransferase TmcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03211">
        <property type="entry name" value="RNA_acetyltr_Nat10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033688">
        <property type="entry name" value="NAT10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007807">
        <property type="entry name" value="TcmA/NAT10_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032672">
        <property type="entry name" value="TmcA/NAT10/Kre33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013562">
        <property type="entry name" value="TmcA/NAT10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027992">
        <property type="entry name" value="tRNA_bind_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925">
        <property type="entry name" value="N-ACETYLTRANSFERASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925:SF5">
        <property type="entry name" value="RNA CYTIDINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13718">
        <property type="entry name" value="GNAT_acetyltr_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05127">
        <property type="entry name" value="NAT10_TcmA_helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08351">
        <property type="entry name" value="TmcA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13725">
        <property type="entry name" value="tRNA_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10 13" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 13" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 13" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="14">
        <location>
            <begin position="558"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="287"/>
            <end position="296"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="470"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="629"/>
            <end position="631"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="636"/>
            <end position="642"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="725"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00065380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00068357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005019159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1025" mass="115391" checksum="B380E4EC65251373" modified="2022-01-19" version="1">MQRRKVDNRIRVLIENGVAERQRGLFVVVGDRGKDQVVILHHMLSKATVKARPSVLWCYKKELGFSSHRKKRMRQLQKKIKSGTLNIKDDDPFELFIAATNIRYCYYNETHKILGNTFGMCVLQDFEALTPNLLARTVETVEGGGIVVILLRTMNSLKQLYTMTMDVHSRYRTEAHQDVVGRFNERFILSLASCKNCIVIDDQLNILPISSHVANITPVPPQSQEDSLRPQDLELKELKESLQDTQPVGVLVDGCKTLDQAKAVLKFIEAISEKTLRSTVALTAARGRGKSAALGLAIAGAVAFGYSNIFVTSPSPDNLHTLFEFIFKGFDALQYQEHLDYEIIQSLNPEFNKAVVRVNVFKEHRQTIQYIHPADSVKLGQAELVVIDEAAAIPLPLVKKLLGPYLVFMASTINGYEGTGRSLSLKLIQQLRQQSAQAQVSMTAENKSTATAKLASARTLHEVSLHESIRYAPGDPVEKWLNDLLCLDCLNITRIISGCPLPEACDLYYVNRDTLFCYHRASEVFLQRLMALYVASHYKNSPNDLQMLSDAPAHHLFCLLPPVPPTQNSLPEVLAVVQVCMEGEISRQSIMNSLSRGKKASGDLIPWTISEQFQDPDFGALSGGRVVRIAVHPDYQGMGYGSRALNLLQMYYEGKFPCLEEKPVQKPKEIATVSSETVSLLEEVVTPRKDLPPLLLKLSERQAESLDYLGVSYGLTPRLLKFWKRAGFVPVYLRQTPNDLTGEHSCIMMKMLNEEDAEQEPWLTAFWKDFRRRFLSLLSYQFSTFSPSLALNILQNKNIKQQSQPPISRAELESAFIPYDLKRLEMYSRNMVDYHLIMDMVPTIARMFFLNQLGDISLSAAQSALLLGIGLQHKSLDQLEKEVELPSSQLMGLFNRIIRKVVQLFNTVQEKAVEEQMVATKDIVMEPTIKSLNDDLEEAAKEFQEKHKQEVGKLKEMDLTQYIIQGDDEEWNEVLSKAGQNASIVSVKRLGKLKYCGKVSPVFPAGFSVMDSTHSASLSCCCRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TXP1</accession>
    <name>A0A8C2TXP1_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methyltransferase 22, Kin17 lysine</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">METTL22</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TXP1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005027473.1">
        <property type="protein sequence ID" value="ENSCJPP00005019877.1"/>
        <property type="gene ID" value="ENSCJPG00005016074.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00510000048539"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038899">
        <property type="entry name" value="METTL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23108:SF0">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23108">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="61"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005019877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="308" mass="34450" checksum="48335EFC7F5EAFDC" modified="2022-01-19" version="1">MGDITEKEMDSGTFKSDAVLSDVHLHCPNKSHLMVRLNAVGQPVFLSCFKLLWNTDDQASEKYRGETTTEREHQYGRGDELPNEDGMNLKCEKELNTEGIEALLDEDGDLEVVRRPQSASDSEAEDLMRDRVYPVILMKGKANAFEDEEQECTYSSVIKIEHTMATPLEDAGKQVCIVPSIVLLLVCCALESVWFNCYSSPKVWRAAFLLADYILFKRDVFRNCTVLELGGGTGIASIIMGMVAKRVYCTDVGEDLLAMCEQNVALNKHLMEPGGKCCTGCVCAIACLWISVELNSISHRRSGWHVYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TXQ9</accession>
    <name>A0A8C2TXQ9_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Protocadherin 11 X-linked</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">PCDH11X</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Potential calcium-dependent cell-adhesion protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TXQ9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005028183.1">
        <property type="protein sequence ID" value="ENSCJPP00005020439.1"/>
        <property type="gene ID" value="ENSCJPG00005016454.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158335"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000005">
        <property type="entry name" value="Protocadherin 9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000016">
        <property type="entry name" value="Protocadherin 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000030">
        <property type="entry name" value="Protocadherin 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000036">
        <property type="entry name" value="Protocadherin 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000069">
        <property type="entry name" value="Protocadherin-11 X-linked"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000077">
        <property type="entry name" value="Protocadherin-11 X-linked"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013164">
        <property type="entry name" value="Cadherin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013585">
        <property type="entry name" value="Protocadherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050174">
        <property type="entry name" value="Protocadherin/Cadherin-CA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028">
        <property type="entry name" value="CADHERIN-87A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028:SF254">
        <property type="entry name" value="PROTOCADHERIN-11 X-LINKED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08266">
        <property type="entry name" value="Cadherin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08374">
        <property type="entry name" value="Protocadherin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 12" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="830"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="50"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="157"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="267"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="379"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="484"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="588"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="702"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="858"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="953"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1016"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1166"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="864"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="881"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1044"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1175"/>
            <end position="1194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005020439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1246" mass="137309" checksum="C9B58CB80234FB9A" modified="2022-01-19" version="1">MKASPGVVHEYSLVSLEMDLLSGTYLLAVLLACIVFQSGAQEKNYTVREELPENVLIGNLLKDLNLTLDPDVPLSSPLQFKLVYKTGDVPLVRVEENTGEIFTTANRIDREKLCSGIFSENRCFYEVEVAVLPDEVFRLVKIRFLIEDINDNAPLFPSTVINISIPENTAINSRYSVPSAIDPDIGMNGIQHYELLKGQNVFGLDIIETPEGDKWPQLIVQQILDREQKDTYVMKIKVEDGGSPPRSSTAILQVTVTDVNDNRPVFKENDIEVSIPENAPVGTSVSQLHATDADLGSNAQIHFYFSNQISSLAKKLFTIDNATGLITIREPLDREESPVHKLTVLASDGSSTPSRATVTVNVTDINDNVPSIDTRYIINPVNGTVLLSEKAPLNTKIALITVMDKDADLNGKVTCFTDHDVPFRLKPVFDNQFLLETATFLDYESTREYAIKIVASDSGKPPLNQSAMLLIKIKDENDNAPVFTQPIIGLSIPENNAPGTQLTKISATDADSGRNAEISYILGSDAPPIFNLDRRTGILTAVRKLDREKQDRYSFTVLAKDNGMPPLQTNATVTVSVLDQNDNSPAFTHSEYNFYVPENLPMYGTVGLITVTDADSGENAAVTLSILNGRDNFIIDPLTGVIRPNITFDREQQGSYTFQVKAVDGGRLQRSSTAKVTINVVDVNDNRPVFVIPSSNYSYELVPISSSPGSVVTKVFAVDNDTGMNAELRYSIIGGNSRGLFAIDQLTGNITLKEKVITSDHGLHRLVIKVNDLGQPESLYTIALVHLFVNETVTNSSYIQELVRRSMETPVGQNIGDGEITPQTNDYVKIIIAIIAGTMTVILVIFVTALVRCRQTPRHKVVQKNKQSGEWVSPNQENRQIKKKKKKKKRSPKSLLLNFVTIEESKPDDPGHEHINGTLDIPVELEEQTMGKYNWATTPTTFKPDSPDLAKHYKSASPQPTFQIKPETPVPPKKHHVIQELPLDNTFVVGCDSLSKCSSSSSDPYSVSECSCQGGFKTPGPIHTRQHTKEMGRPQTPLKESTLEPWTQPQPQRRVTFHLPDGSQESCSDSGLGDHEPSSGASTSHPLPLGFPQEEYYEQASPNSRTEGDGNSDPESTIEVNLQKALAEASETCTQECLILGHSDNCWMPPSLTQYQQSNTTLPSFGFQQSWGRGARSDGRHTLGRPLPKDDTDKGQGGPRPQFYNSCERHCTSEDPVKVIPLANFAMSHQAAVSGNSTTFIHEHQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TXZ8</accession>
    <name>A0A8C2TXZ8_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">GDNF family receptor alpha-2</fullName>
            <shortName evidence="12">GDNF receptor alpha-2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">GFRA2</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Receptor for neurturin (NRTN), a growth factor that supports the survival of sympathetic neurons. NRTN-binding leads to autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the GDNFR family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015738663.1">
        <property type="nucleotide sequence ID" value="XM_015883177.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TXZ8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005025864.1">
        <property type="protein sequence ID" value="ENSCJPP00005018615.1"/>
        <property type="gene ID" value="ENSCJPG00005015143.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107323784"/>
    <dbReference type="KEGG" id="cjo:107323784"/>
    <dbReference type="CTD" id="2675"/>
    <dbReference type="GeneTree" id="ENSGT00940000156168"/>
    <dbReference type="OrthoDB" id="9435188at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016167">
        <property type="term" value="F:glial cell-derived neurotrophic factor receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904399">
        <property type="term" value="F:heparan sulfate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.110:FF:000001">
        <property type="entry name" value="GDNF family receptor alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.110">
        <property type="entry name" value="GDNF binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016017">
        <property type="entry name" value="GDNF/GAS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037193">
        <property type="entry name" value="GDNF_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003438">
        <property type="entry name" value="GDNF_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003504">
        <property type="entry name" value="GDNF_rcpt_a2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017372">
        <property type="entry name" value="Glial_neurotroph_fac_rcpt_a1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10269:SF4">
        <property type="entry name" value="GDNF FAMILY RECEPTOR ALPHA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10269">
        <property type="entry name" value="GDNF RECEPTOR ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02351">
        <property type="entry name" value="GDNF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038071">
        <property type="entry name" value="GDNF_family_receptor_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01318">
        <property type="entry name" value="GDNFRALPHA2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01316">
        <property type="entry name" value="GDNFRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00907">
        <property type="entry name" value="GDNF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110035">
        <property type="entry name" value="GDNF receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10 14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034356209" description="GDNF family receptor alpha-2" evidence="12">
        <location>
            <begin position="22"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="GDNF/GAS1" evidence="15">
        <location>
            <begin position="40"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="GDNF/GAS1" evidence="15">
        <location>
            <begin position="159"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="GDNF/GAS1" evidence="15">
        <location>
            <begin position="249"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="14">
        <location>
            <position position="355"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="14">
        <location>
            <position position="412"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="47"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="159"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="166"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="183"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="193"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="222"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="249"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="256"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="283"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="323"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR038071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR038071-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR038071-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005018615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="467" mass="52120" checksum="2F7191C25FCB6D29" modified="2022-01-19" version="1">MILANAFCIVLFVDETLRSLATPPSPPGQDLQGWRVPVDCVRASELCAAEGSCSSRYRTLRQCLAGRDRNTMLANKECQAALEVLQESPLYDCRCKRGMKKELQCLQIYWSIHLGLAEGEEFYEASPYEPITSRLSDIFRLASIFSGMDPATNSKSNHCLDAAKACNLNDNCKRLRSGYISTCNKEISATEHCSRRKCHKALRQFFDRVPSEYTYRLLFCSCKDQACAERRRQTIVPSCSYEDKEKPNCLDLRNVCRADHLCRSRLADFHANCQASFQSLTNCPGDNYQACLGSYTGLIGFDMTPNYVDASTTSITISPWCSCKGSGNLEEECEKFLRDFTENPCLRNAIQAFGNGTDVNLSPKNPSPPITVLPKVEKSPALPDDINDSNTMYDTSIITTCTSIQEHGQKLNKSKEQSLCYSETQLTTDTMPDQKSFVDQKAAASSRHRAAQILPAVPIVLLKLLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TYM4</accession>
    <name>A0A8C2TYM4_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Hypoxanthine phosphoribosyltransferase</fullName>
            <ecNumber evidence="16">2.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">HPRT1</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>GMP + diphosphate = guanine + 5-phospho-alpha-D-ribose 1-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:25424"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="EC" id="2.4.2.8"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="14">
            <dbReference type="Rhea" id="RHEA:25426"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:17973"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="2.4.2.8"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="15">
            <dbReference type="Rhea" id="RHEA:17975"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 16">Purine metabolism; IMP biosynthesis via salvage pathway; IMP from hypoxanthine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 16">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.8" evidence="16"/>
    <dbReference type="RefSeq" id="XP_015715837.1">
        <property type="nucleotide sequence ID" value="XM_015860351.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TYM4"/>
    <dbReference type="SMR" id="A0A8C2TYM4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005027928.1">
        <property type="protein sequence ID" value="ENSCJPP00005020250.1"/>
        <property type="gene ID" value="ENSCJPG00005016326.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107312700"/>
    <dbReference type="KEGG" id="cjo:107312700"/>
    <dbReference type="CTD" id="3251"/>
    <dbReference type="GeneTree" id="ENSGT00940000155028"/>
    <dbReference type="OrthoDB" id="9449045at2759"/>
    <dbReference type="UniPathway" id="UPA00591">
        <property type="reaction ID" value="UER00648"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052657">
        <property type="term" value="F:guanine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004422">
        <property type="term" value="F:hypoxanthine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046083">
        <property type="term" value="P:adenine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021954">
        <property type="term" value="P:central nervous system neuron development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021895">
        <property type="term" value="P:cerebral cortex neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048813">
        <property type="term" value="P:dendrite morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042417">
        <property type="term" value="P:dopamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071542">
        <property type="term" value="P:dopaminergic neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046038">
        <property type="term" value="P:GMP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032263">
        <property type="term" value="P:GMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007625">
        <property type="term" value="P:grooming behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006178">
        <property type="term" value="P:guanine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043103">
        <property type="term" value="P:hypoxanthine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007626">
        <property type="term" value="P:locomotory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046651">
        <property type="term" value="P:lymphocyte proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045964">
        <property type="term" value="P:positive regulation of dopamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051289">
        <property type="term" value="P:protein homotetramerization"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001975">
        <property type="term" value="P:response to amphetamine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021756">
        <property type="term" value="P:striatum development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001913">
        <property type="term" value="P:T cell mediated cytotoxicity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000019">
        <property type="entry name" value="Hypoxanthine phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050408">
        <property type="entry name" value="HGPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005904">
        <property type="entry name" value="Hxn_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01203">
        <property type="entry name" value="HGPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43340">
        <property type="entry name" value="HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43340:SF6">
        <property type="entry name" value="HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 16" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 16" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="17">
        <location>
            <begin position="41"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008391"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU364099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005020250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="218" mass="24609" checksum="2228B84B0B6AF727" modified="2022-01-19" version="1">MATHSPCIVIGDDEQGYDLDLFCIPKHYADDLEKVYIPHGLIMDRTERLAREIMKGMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSDKSIPMTVDFIRLKSYCNDQSTGDIKVIGGDDLSTLTGKNVLIVEDIIDTGKTMKTLLSLLKQYNPKMVKVASLLVKRTPRSVGYRPDFVGFEVPDKFVVGYALDYNEYFRDLNHICVISETGKQKYKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TZK3</accession>
    <name>A0A8C2TZK3_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized LOC107317856</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC107317856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015726484.1">
        <property type="nucleotide sequence ID" value="XM_015870998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TZK3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005028958.1">
        <property type="protein sequence ID" value="ENSCJPP00005021046.1"/>
        <property type="gene ID" value="ENSCJPG00005016863.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107317856"/>
    <dbReference type="KEGG" id="cjo:107317856"/>
    <dbReference type="GeneTree" id="ENSGT01030000235137"/>
    <dbReference type="OrthoDB" id="9014577at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005021046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="288" mass="33579" checksum="128BE48051435B37" modified="2022-01-19" version="1">MESLDTEVKARKTLGTVEYVESSGFTQGILPTKKDVVQNMLYLLQPKRAGQAQRSKEDAAQLLAEHLQEHWLVCNLHTIGTQSIKKLILKMYEEFTRLYQTRKQRQNQAYTERADKFNESSEKLFDIFCVDTHMRNKLEEYSGIKMTGIELKFLEDQRSERKMYYEDFTDKQELKMMERRQKIQCLEHFRKLAREEKEGNKAKGTTYKTDEQSDEGTSVDEAYPVEEENGGAPAFSLRGRRKRRCTAWSAGAATPASDAMPLECQHIRMSIRRVRPGFYETVEKVENC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U0K1</accession>
    <name>A0A8C2U0K1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">MYLIP</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="RefSeq" id="XP_015710208.1">
        <property type="nucleotide sequence ID" value="XM_015854722.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U0K1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005029513.1">
        <property type="protein sequence ID" value="ENSCJPP00005021490.1"/>
        <property type="gene ID" value="ENSCJPG00005017194.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107309697"/>
    <dbReference type="KEGG" id="cjo:107309697"/>
    <dbReference type="CTD" id="29116"/>
    <dbReference type="GeneTree" id="ENSGT00940000156206"/>
    <dbReference type="OrthoDB" id="10037309at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008092">
        <property type="term" value="F:cytoskeletal protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042632">
        <property type="term" value="P:cholesterol homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010989">
        <property type="term" value="P:negative regulation of low-density lipoprotein particle clearance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010977">
        <property type="term" value="P:negative regulation of neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045732">
        <property type="term" value="P:positive regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031648">
        <property type="term" value="P:protein destabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032803">
        <property type="term" value="P:regulation of low-density lipoprotein particle receptor catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13195">
        <property type="entry name" value="FERM_C_MYLIP_IDOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17104">
        <property type="entry name" value="FERM_F1_MYLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16523">
        <property type="entry name" value="RING-HC_MYLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1170.10:FF:000002">
        <property type="entry name" value="Baculoviral IAP repeat containing 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000019">
        <property type="entry name" value="E3 ubiquitin-protein ligase MYLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000129">
        <property type="entry name" value="E3 ubiquitin-protein ligase MYLIP isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000164">
        <property type="entry name" value="Putative E3 ubiquitin-protein ligase MYLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000175">
        <property type="entry name" value="Putative E3 ubiquitin-protein ligase MYLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000798">
        <property type="entry name" value="Ez/rad/moesin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018979">
        <property type="entry name" value="FERM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018980">
        <property type="entry name" value="FERM_PH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041790">
        <property type="entry name" value="MYLIP_FERM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23280">
        <property type="entry name" value="4.1 G PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23280:SF13">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MYLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09380">
        <property type="entry name" value="FERM_C"/>
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    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00935">
        <property type="entry name" value="BAND41"/>
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        <property type="entry name" value="ERMFAMILY"/>
    </dbReference>
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        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
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    </dbReference>
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        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FERM" evidence="12">
        <location>
            <begin position="1"/>
            <end position="279"/>
        </location>
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        <location>
            <begin position="387"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
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        <source>
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            <dbReference type="ARBA" id="ARBA00022723"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022833"/>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005021490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="445" mass="50138" checksum="4CF0BC5722E6E39B" modified="2022-01-19" version="1">MLCYVTRPDAVVMEVEVEAKANGEDCLNQVCRRLGIIEVDYFGLQFTGSKGENLWLNLRNRISQQMDGLAPYRFKLRVKFFVEPHLILQEQTRHMFFLHIKEDLLAGNLQCSSEHAIELSALLAQMKFGDYNQNTAKYNYEELCAKELTTTILESIIAKHKDLEGLSQASAEYQILQIVTTLENYGVEWHSVRDSEGQKLLIGVGPEGISICKEDFSPINRIAYPVVQMATQSGKNVYLTVTKESGNSVVLLFKMISTRAASGLYRAITETHAFYRCDTVTSAVMMQYSRDLKGHLASLFLNENINLGKKYVFDIKRTSKEVYDHARRALYNAGIVDLVSRSDQTPPSSPLKSSESSMNCDNCEGLSCQQTKALQEKLRKLKESMLCMVCCEEEINSTFCPCGHTVCCKACAAQLQSCPVCRSRVEHVQHVYLPTHTSLLNLTVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U0U8</accession>
    <name>A0A8C2U0U8_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Integrin alpha FG-GAP repeat containing 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ITFG2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U0U8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005028571.1">
        <property type="protein sequence ID" value="ENSCJPP00005020725.1"/>
        <property type="gene ID" value="ENSCJPG00005016633.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000005378"/>
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        <property type="component" value="Chromosome 1"/>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="C:lysosomal membrane"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:cellular response to amino acid starvation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
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    </dbReference>
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        <property type="entry name" value="Integrin_alpha_N"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR16317:SF1">
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    </dbReference>
    <dbReference type="Pfam" id="PF15907">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005020725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="459" mass="50461" checksum="06F1A9020F01EA2F" modified="2022-01-19" version="1">MRSVSYVQRVALEFSGSLFPHAICLGDADNDTLNELVVGDTNGKLYVYKNDDSKPWTVRSCQGMLTCVGVGDVCNKGKNLTVAVSAEGWFHLFDLTSPSKHSDTSGHHELAEEQKPVFKQHIPANTKVMLISDIDGDGKCELVVGYTDRVVRAFRWEDSSENSDHVCGQLILLKKWLLEGQVDSLSVNPGPNGLPEMMVSQPGCGYAILLCTWDSEQQPVVEGSDSSSPSRETPVRDVILHQTSGRIHNKNVSTHLIGSIGRGCSNVGNGSGLFALCTLDGTLKLMEGADKLLWSVQVDHQLFALEKLDVTGNGHEEVIACAWDGQTYIIDHNRTVARFQADENVSAFCAGLYACKRGSNSPCLVYVSFNQKIYIYWDVQLERMESTNLLKILENDPEFDSLLQELGVGDDVPAVQDLIYKTLYFPEKLQPNSALQCQNPAGTDSSAHHTVIHKPLQDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U168</accession>
    <name>A0A8C2U168_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ciliary microtubule inner protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">CIMIP3</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U168"/>
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        <property type="gene ID" value="ENSCJPG00005016659.1"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054446">
        <property type="entry name" value="CIMIP3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35444">
        <property type="entry name" value="RIKEN CDNA 1700001C19 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35444:SF1">
        <property type="entry name" value="RIKEN CDNA 1700001C19 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22581">
        <property type="entry name" value="CIMIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005020746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="117" mass="13537" checksum="5CD8A9ABC5CD3536" modified="2022-01-19" version="1">LPLSPRCRRSTLPSRPQRGEAFARRLFASQRRTDQTLASRFVPVVAHPGGQDPDSFRFCFYTRRCSNSYSPFYTSQRPTCGYHFHYDTDHTRKVMDIQSANLAKWGPKPTQSPRAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U1M6</accession>
    <name>A0A8C2U1M6_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UbiA prenyltransferase domain-containing protein 1</fullName>
            <ecNumber evidence="14">2.5.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">UBIAD1</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>all-trans-decaprenyl diphosphate + 4-hydroxybenzoate = 4-hydroxy-3-(all-trans-decaprenyl)benzoate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:44564"/>
            <dbReference type="ChEBI" id="CHEBI:17879"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60721"/>
            <dbReference type="ChEBI" id="CHEBI:84503"/>
            <dbReference type="EC" id="2.5.1.39"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:44565"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>menadiol + (2E,6E,10E)-geranylgeranyl diphosphate = menaquinol-4 + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:74083"/>
            <dbReference type="ChEBI" id="CHEBI:6746"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58756"/>
            <dbReference type="ChEBI" id="CHEBI:193091"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:74084"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.39" evidence="14"/>
    <dbReference type="RefSeq" id="XP_015737922.1">
        <property type="nucleotide sequence ID" value="XM_015882436.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015737923.1">
        <property type="nucleotide sequence ID" value="XM_015882437.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032304649.1">
        <property type="nucleotide sequence ID" value="XM_032448758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U1M6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005030060.1">
        <property type="protein sequence ID" value="ENSCJPP00005021946.1"/>
        <property type="gene ID" value="ENSCJPG00005017513.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107323409"/>
    <dbReference type="KEGG" id="cjo:107323409"/>
    <dbReference type="CTD" id="29914"/>
    <dbReference type="GeneTree" id="ENSGT00390000012439"/>
    <dbReference type="OrthoDB" id="203513at2759"/>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008412">
        <property type="term" value="F:4-hydroxybenzoate polyprenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042371">
        <property type="term" value="P:vitamin K biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd13962">
        <property type="entry name" value="PT_UbiA_UBIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.140:FF:000005">
        <property type="entry name" value="UbiA prenyltransferase domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1780">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026046">
        <property type="entry name" value="UBIAD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13929">
        <property type="entry name" value="1,4-DIHYDROXY-2-NAPHTHOATE OCTAPRENYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13929:SF0">
        <property type="entry name" value="UBIA PRENYLTRANSFERASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005355">
        <property type="entry name" value="UBIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="148"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="204"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005021946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="327" mass="35261" checksum="DF31A38BA0C7453A" modified="2022-01-19" version="1">MGPAELVQKISINAERNECGPGAERGPAGGWRQKCAAYVLALRPWSFSASLTPVALGSALAYRAQGALDPRLLVGSAVVVLAVHGAGNLVNTYYDFSKGIDHKKSDDRTLVDQILEPQDVVRFGVFLYTVGCVCAAGLYVVSTLKLEHLALIYFGGLSSSFLYTGGIGFKYVALGDVVILITFGPLAVMFAHAVQVGYLSVSPLLYAVPLALSTEAILHSNNTRDMESDQQAGIVTLAILIGPAFSYVLYTVLLFLPYLIFCVLATRYTISMALPLLTIPMAFSLERQFRSQNFNKIPQRTAKLNLLLGLFYVFGIMLAPAGALPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U3N6</accession>
    <name>A0A8C2U3N6_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Rap guanine nucleotide exchange factor 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Exchange factor directly activated by cAMP 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Exchange protein directly activated by cAMP 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">cAMP-regulated guanine nucleotide exchange factor II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">RAPGEF4</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA-independent exocytosis through interaction with RIMS2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015723983.1">
        <property type="nucleotide sequence ID" value="XM_015868497.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U3N6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005030517.1">
        <property type="protein sequence ID" value="ENSCJPP00005022231.1"/>
        <property type="gene ID" value="ENSCJPG00005017761.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107316695"/>
    <dbReference type="KEGG" id="cjo:107316695"/>
    <dbReference type="CTD" id="11069"/>
    <dbReference type="GeneTree" id="ENSGT00940000156075"/>
    <dbReference type="OrthoDB" id="21144at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030552">
        <property type="term" value="F:cAMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017156">
        <property type="term" value="P:calcium-ion regulated exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030073">
        <property type="term" value="P:insulin secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032024">
        <property type="term" value="P:positive regulation of insulin secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017157">
        <property type="term" value="P:regulation of exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098693">
        <property type="term" value="P:regulation of synaptic vesicle cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd04437">
        <property type="entry name" value="DEP_Epac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1240:FF:000001">
        <property type="entry name" value="Rap guanine nucleotide exchange factor (GEF) 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000096">
        <property type="entry name" value="Rap guanine nucleotide exchange factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.840.10:FF:000002">
        <property type="entry name" value="Rap guanine nucleotide exchange factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.870.10:FF:000005">
        <property type="entry name" value="Rap guanine nucleotide exchange factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000015">
        <property type="entry name" value="Rap guanine nucleotide exchange factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000052">
        <property type="entry name" value="Rap guanine nucleotide exchange factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000038">
        <property type="entry name" value="Rap guanine nucleotide exchange factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019804">
        <property type="entry name" value="Ras_G-nucl-exch_fac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF175">
        <property type="entry name" value="RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00103">
        <property type="entry name" value="CAMPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00720">
        <property type="entry name" value="RASGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0114">cAMP</keyword>
    <keyword evidence="5" id="KW-0116">cAMP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="6 16" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="18">
        <location>
            <begin position="43"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="DEP" evidence="19">
        <location>
            <begin position="231"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="18">
        <location>
            <begin position="371"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="20">
        <location>
            <begin position="511"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="17">
        <location>
            <begin position="787"/>
            <end position="1024"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00057413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00076925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00077599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00081536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005022231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1026" mass="117037" checksum="049C74BC2A66958C" modified="2022-01-19" version="1">MVAAHTSHSASSGEWIACLDKRPLERSSEDVDIIFTRLKEVKAFEKFHPNLLQQICLCGYYENLEKGITLFRQGDIGSNWYAVLTGSLDVKVSDTSNHQDAVTICTLGIGTAFGESILDNTPRHATIVTREYSELLRIEQKDFKALWEKYRQYMSGLLTPPYGVMETGSNNDRMPDKDSMSSGALCQVSKNCNKTPLIDSHIPHRPSKTITQVPSEKILRAGKILRNTILSRAPHMIRDRKYHLKTYRQCCVGTELVDWMMQQSTCVHSRSQAVGMWQVLLEEGVLNHVDQEHHFQDKYLFYRFLDDEREDAPLPTEEEKKECDEELQDTMLLLSQIGPDAHMRMILRKPPGQRSMDDLEIIYEELLHIKALSHLSTTVKRELAGVLIFESHPKAGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKIPAGNRVSNQGSSQPQHKYIVMSGTPEKILEHFLETMRLEATLNEATDSALNDFIMMHCVFMPNSQLCPALMAHYHAQPSQGTEQEKMDYALNNKRRVIRLVLQWAALYGDLLQEDEAAMAFLEEFYVSVSDDTRMIAALKEQLPELEKIVKQVAEEPKGPQKKHKVLLQLFNTSDDRAQKRQPIRGSDEVLFKVYCIDQTYTTIRVPVSSSVKEVISAVADKLGSGEGLIIVKMSSGGEKVVLKPHDVSVFTTLSVNGRLFACPRDQFDSLAPLPEQEGPSAGTVGTFELMSSKDLAHQMTIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEICLCSQLSKRVQILKKYIKIAAHCKEYKNLNSFFAIIMGLSNVAVSRLSLTWEKLPSKFKKIYAEFESLMDPSRNHRAYRLTVAKLDPPIIPFMPLLIKDMTFTHEGNKTLTDNLVNFEKMRMIANTVRTVKFCRSQSFNPDAALANKNHQDVRSYVRQLNVIDNQRTLSQMSHRLEPRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U4Y8</accession>
    <name>A0A8C2U4Y8_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Lipoyl synthase, mitochondrial</fullName>
            <ecNumber evidence="9">2.8.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Lipoate synthase</fullName>
            <shortName evidence="9">LS</shortName>
            <shortName evidence="9">Lip-syn</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Lipoic acid synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">LIAS</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine + 4 H(+) = [[Fe-S] cluster scaffold protein] + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 5'-deoxyadenosine + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:16585"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:14568"/>
            <dbReference type="Rhea" id="RHEA-COMP:14569"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33722"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="2.8.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the radical SAM superfamily. Lipoyl synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.8" evidence="9"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2U4Y8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005030667.1">
        <property type="protein sequence ID" value="ENSCJPP00005022379.1"/>
        <property type="gene ID" value="ENSCJPG00005017828.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000006234"/>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00593"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016992">
        <property type="term" value="F:lipoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001843">
        <property type="term" value="P:neural tube closure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032496">
        <property type="term" value="P:response to lipopolysaccharide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000036">
        <property type="entry name" value="Lipoyl synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00206">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031691">
        <property type="entry name" value="LIAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003698">
        <property type="entry name" value="Lipoyl_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00510">
        <property type="entry name" value="lipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004019">
        <property type="entry name" value="PRK05481.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009544">
        <property type="entry name" value="PRK12928.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949">
        <property type="entry name" value="LIPOYL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949:SF0">
        <property type="entry name" value="LIPOYL SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16881">
        <property type="entry name" value="LIAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00271">
        <property type="entry name" value="lipoyl_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01058">
        <property type="entry name" value="lipoyl_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="11">
        <location>
            <begin position="144"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="7"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="374"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005022379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="394" mass="43807" checksum="65B2A9E2FCC59539" modified="2022-01-19" version="1">MVFILQTTTTTSCSPGGTAAPRTAPLPARTRGPQLRCPGSSRPQTTYGTSSSLPEETKKALQTGPDLEDFLSGDLADKSVWAEYKGNLKRQKGERLRLPPWLKTEIPMGKNYNKLKNTLRSLNLHTVCEEARCPNIGECWGGGEYATATATIMLMGDTCTRGCRFCSVKTAKNPPPLDPEEPYNTAKAIAEWGLDYVVLTSVDRDDMPDGGAEHFAKTVSHLKERNPKIVVECLTPDFRGDLSAVEKVALSGLDVYAHNVETVPELQRRVRDPRANFEQSLRVLQHAKEVQPRVISKTSLMLGLGETDAQVLSTMKLLREAGVDCLTLGQYMQPTKRHLKVEEYVTPEKFKYWEKVGNDLGFHYTASGPLVRSSYKAGEFFLKNLVEKRKTKVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U545</accession>
    <name>A0A8C2U545_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Dual specificity protein phosphatase 12</fullName>
            <ecNumber evidence="5">3.1.3.16</ecNumber>
            <ecNumber evidence="4">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">DUSP12</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Dual specificity phosphatase; can dephosphorylate both phosphotyrosine and phosphoserine or phosphothreonine residues. Can dephosphorylate glucokinase (in vitro). Has phosphatase activity with the synthetic substrate 6,8-difluoro-4-methylumbelliferyl phosphate and other in vitro substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="5"/>
    <dbReference type="EC" id="3.1.3.48" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2U545"/>
    <dbReference type="Ensembl" id="ENSCJPT00005029509.1">
        <property type="protein sequence ID" value="ENSCJPP00005021486.1"/>
        <property type="gene ID" value="ENSCJPG00005017176.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00930000151041"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008138">
        <property type="term" value="F:protein tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000056">
        <property type="entry name" value="Dual specificity phosphatase 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016278">
        <property type="entry name" value="DUSP12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45848:SF4">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45848">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000941">
        <property type="entry name" value="DUSP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="16">
        <location>
            <begin position="43"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="17">
        <location>
            <begin position="100"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="15">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00068797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000941-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005021486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="352" mass="37879" checksum="CF861B57ECDDD813" modified="2022-01-19" version="1">MILEVPSNPGHSVILCDSVNLPLLGTAGSRHYGRDRSRSRGGGMVPVLPGLYVGGAESCSSSKALEAAGVMAVLTVDAEEPPPVPGLQSLYIRALDEPGADLLSRLDECAAFIGAARAGGGAVLVRCQAGVSRSVAVVTAYLMKTQGLGWEEAYAAVRAAKPDAEVNPGFQRQLKLYEAMGCVVDSSSALYKQHRLQVLTERFSDLQDLPQEVFAVDPTNTHQTPNTEVLYRCRKCRRALFRSSSILSHMEGSGPTAFAHKRITESMHLRGSGPAKCTSYFIEPVQWMEPALLGVTEGQLLCPKCTSKLGSFSWWGEQCSCGHWVTPAFQIHKSRVDEARTLSVGNFPAAKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U6L6</accession>
    <name>A0A8C2U6L6_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">BAI1-associated protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Membrane-associated guanylate kinase inverted 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">MAGI1</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Plays a role in coupling actin fibers to cell junctions in endothelial cells, via its interaction with AMOTL2 and CDH5. May regulate acid-induced ASIC3 currents by modulating its expression at the cell surface.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Tight junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015730688.1">
        <property type="nucleotide sequence ID" value="XM_015875202.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005031099.1">
        <property type="protein sequence ID" value="ENSCJPP00005022697.1"/>
        <property type="gene ID" value="ENSCJPG00005018045.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107319886"/>
    <dbReference type="CTD" id="9223"/>
    <dbReference type="GeneTree" id="ENSGT00940000155820"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U6W1</accession>
    <name>A0A8C2U6W1_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Homeobox D3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">HOXD3</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Antp homeobox family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015723937.1">
        <property type="nucleotide sequence ID" value="XM_015868451.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015723938.1">
        <property type="nucleotide sequence ID" value="XM_015868452.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015723941.1">
        <property type="nucleotide sequence ID" value="XM_015868455.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U6W1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005030460.1">
        <property type="protein sequence ID" value="ENSCJPP00005022194.1"/>
        <property type="gene ID" value="ENSCJPG00005017726.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107316673"/>
    <dbReference type="KEGG" id="cjo:107316673"/>
    <dbReference type="CTD" id="3232"/>
    <dbReference type="GeneTree" id="ENSGT00940000160027"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016235">
        <property type="term" value="C:aggresome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009952">
        <property type="term" value="P:anterior/posterior pattern specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051216">
        <property type="term" value="P:cartilage development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048704">
        <property type="term" value="P:embryonic skeletal system morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021615">
        <property type="term" value="P:glossopharyngeal nerve morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045666">
        <property type="term" value="P:positive regulation of neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030878">
        <property type="term" value="P:thyroid gland development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000094">
        <property type="entry name" value="Homeobox protein Hox-A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025281">
        <property type="entry name" value="DUF4074"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001827">
        <property type="entry name" value="Homeobox_Antennapedia_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45664:SF5">
        <property type="entry name" value="HOMEOBOX PROTEIN HOX-D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45664">
        <property type="entry name" value="PROTEIN ZERKNUELLT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13293">
        <property type="entry name" value="DUF4074"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00032">
        <property type="entry name" value="ANTENNAPEDIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6 10 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0371">Homeobox</keyword>
    <keyword evidence="9 10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="13">
        <location>
            <begin position="176"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="10">
        <location>
            <begin position="178"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="65"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="150"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="236"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="381"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="107"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="392"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005022194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="413" mass="43290" checksum="131DCD7327151F37" modified="2022-01-19" version="1">MIFEQGPRALAIAESKMQKTAYYDNAGLFGGYTYGKADAYPYGAAQQPYGAAGLDGEYPGSACSVQGSAPGRGPAPKGPELGGSCMRTAGGGPGGSQPPGIGEQQPPALPPSSPPNPSSAPPPKKAKGGPNASGSASATLSKQIFPWMKESRQNSKQKSTCPPSGESCEDKSPPGPASKRVRTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLTERQIKIWFQNRRMKYKKDQKAKGIMHSPAGQSPERSPPLSGAAHAGYSGQLPAVGGLGYDAPSPTPFAKAQQSMYGLAAYTAPLGGCLPQQKRYAGAEYEPHPLQSGGGFGNPGLQGSPVYVGGNFVDSMPASGPVFNLGHLQHPSSASVDYSCAAQIPGGHHHGPCDPHPTYTDLSSHHASQGRLQEAPKLTHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U6X7</accession>
    <name>A0A8C2U6X7_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Glycoprotein Ib platelet subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">GP1BB</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015733057.1">
        <property type="nucleotide sequence ID" value="XM_015877571.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U6X7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005032937.1">
        <property type="protein sequence ID" value="ENSCJPP00005024138.1"/>
        <property type="gene ID" value="ENSCJPG00005019060.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107321060"/>
    <dbReference type="KEGG" id="cjo:107321060"/>
    <dbReference type="CTD" id="2812"/>
    <dbReference type="GeneTree" id="ENSGT00530000064244"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990779">
        <property type="term" value="C:glycoprotein Ib-IX-V complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007597">
        <property type="term" value="P:blood coagulation, intrinsic pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010572">
        <property type="term" value="P:positive regulation of platelet activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052313">
        <property type="entry name" value="GPIb-IX-V_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22650">
        <property type="entry name" value="GLYCOPROTEIN IB BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22650:SF7">
        <property type="entry name" value="PLATELET GLYCOPROTEIN IB BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034220527" evidence="10">
        <location>
            <begin position="20"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="143"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="LRRCT" evidence="11">
        <location>
            <begin position="84"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005024138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="199" mass="22880" checksum="79A6FECE66D6EFFB" modified="2022-01-19" version="1">MNSGILFLSLLGFLPFVTPTCPSPCKCATNIIDCMSKGLTVTKLPAAFRPSAEIINLSYNRLTSIPSGLFDNLQSLQAVHLQGNPWECNCDILYLRSWLQWQQNRTFYRDVRCASPAHLQGRVIAYLTEDEISSTCQYWYCTLAFFSQVVLIVLLFLQAVLVIFIIIYLQRFRRMTAEARSTTRDLYQQQADTWSLQER</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U8E2</accession>
    <name>A0A8C2U8E2_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">B cell linker</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BLNK</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015722666.1">
        <property type="nucleotide sequence ID" value="XM_015867180.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U8E2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005033745.1">
        <property type="protein sequence ID" value="ENSCJPP00005024774.1"/>
        <property type="gene ID" value="ENSCJPG00005019504.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107316071"/>
    <dbReference type="KEGG" id="cjo:107316071"/>
    <dbReference type="CTD" id="29760"/>
    <dbReference type="GeneTree" id="ENSGT00940000155715"/>
    <dbReference type="OrthoDB" id="10044490at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140693">
        <property type="term" value="F:molecular condensate scaffold activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043274">
        <property type="term" value="F:phospholipase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990782">
        <property type="term" value="F:protein tyrosine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042169">
        <property type="term" value="F:SH2 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050853">
        <property type="term" value="P:B cell receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd09929">
        <property type="entry name" value="SH2_BLNK_SLP-76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000016">
        <property type="entry name" value="B-cell linker protein isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051751">
        <property type="entry name" value="Immunoreceptor_sig_adapters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14098:SF3">
        <property type="entry name" value="B-CELL LINKER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14098">
        <property type="entry name" value="SH2 DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="SH2" evidence="4">
        <location>
            <begin position="491"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="103"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="123"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="217"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="237"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="366"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="417"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005024774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="601" mass="67211" checksum="028C2A3F9BCACD31" modified="2022-01-19" version="1">MATKLPSQEECEGWTAFQVADLLRQFGMPESAVLVEKLGMDGSHFLNLSDYELSRFKIMHQPKLQKMVHDIKKNESGIINKFKKFQNEQVALICKTGKDTWDRLKKKTPPSLPQRDYASEHADNEEEQWSDDFDSDYENPDGHSDSEMYVVPSEENPDDSYEPPPSEQENKKIPSAFPISRGEYADNRTSHHQLPPINKPLPSTPSSALPRPKKPSKPSLPSPATKPKLPPKPRECSDDEDNYIVPVDNDDDNYIEPTEGSAPLPVKPPVNRFTKPPTKSALPTPAKPSLASDMQEVYEVPEEEEELSPPPVSRFTKPLPATRAQNAEHSHMHSMTRESPKLDTSRNILPLPRNRLHPKTDHEANNNDANHSFNNTQESKFPTGAAPSPLPRALKKTSNAVNPAKPCLPSRDNFTVNEDKPTAAERRQGSSHEFPLPPLPSGNPKSSLQKPLILPKVPEAPSRALGTSPHSSISSISSTADQDAGVHSKAWYAATCDRKTAEDALYRSNKDGSFLIRKSSGQDSRQPYTLVVFYNRRVYNIPIRFIESTGQYALGREKCGEERFDSVAEIVENHQHTSLVLIDSQNNTKDSTKLKYIVRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U919</accession>
    <name>A0A8C2U919_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Translation initiation factor eIF2B subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">eIF2B GDP-GTP exchange factor subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">EIF2B1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on eukaryotic initiation factor 2 (eIF2) gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2U919"/>
    <dbReference type="SMR" id="A0A8C2U919"/>
    <dbReference type="Ensembl" id="ENSCJPT00005034502.1">
        <property type="protein sequence ID" value="ENSCJPP00005025355.1"/>
        <property type="gene ID" value="ENSCJPG00005019910.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00550000074853"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002183">
        <property type="term" value="P:cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014003">
        <property type="term" value="P:oligodendrocyte development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050852">
        <property type="term" value="P:T cell receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1070:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 2B subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10470:FF:000001">
        <property type="entry name" value="Translation initiation factor eIF-2B subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1070">
        <property type="entry name" value="Translation initiation factor eIF-2B, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051501">
        <property type="entry name" value="eIF2B_alpha/beta/delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042528">
        <property type="entry name" value="elF-2B_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45860">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45860:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005025355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="302" mass="33594" checksum="D089D91EBB1A2E01" modified="2022-01-19" version="1">MSTDDLIETFRAQLRDDPDVASAVAAIRALLGFLRQDRGETIQGLRSSLRDAIDTLSRVDSSVAVNSGGELFLRFISLTSLEYSDYSKCKEIMIERGEIFLRKVSLSRNKIAKLCHPFIRDGARILTHAYSRVVLRVLEAAVESKKRFSVYVTESQPDQAGQKMAKALRKLNIPVTVILDAAVGYIMEKVDLVLVGAEGVVESGGIINKIGTNQIAVCAKAQNKPFYVVAESFKFVRLFPLNQQDVPDKFKYKADTLKTSQNLTEEHPWIDYTSPSLITLLFTDLGVLTPSAVSDELIKLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U991</accession>
    <name>A0A8C2U991_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Twist-related protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC107325715</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_032296968.1">
        <property type="nucleotide sequence ID" value="XM_032441077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U991"/>
    <dbReference type="Ensembl" id="ENSCJPT00005034593.1">
        <property type="protein sequence ID" value="ENSCJPP00005025439.1"/>
        <property type="gene ID" value="ENSCJPG00005019961.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107325715"/>
    <dbReference type="KEGG" id="cjo:107325715"/>
    <dbReference type="GeneTree" id="ENSGT00940000162831"/>
    <dbReference type="OrthoDB" id="8583783at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome LGE22C19W28_E50C23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11412">
        <property type="entry name" value="bHLH_TS_TWIST1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000030">
        <property type="entry name" value="Twist transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050283">
        <property type="entry name" value="E-box_TF_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047093">
        <property type="entry name" value="TWIST1_bHLH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349:SF66">
        <property type="entry name" value="TWIST HOMLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="2" id="KW-0221">Differentiation</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="8">
        <location>
            <begin position="67"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005025439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="161" mass="18435" checksum="9B0EEE90FA6BB6F5" modified="2022-01-19" version="1">MKEENMCPESPEGSLVTSEEEGERLHKKCLRKRGQAGKALEDGRATSPQGKRCKRSPVPQSFEDVHTQRVIANVRERQRTQSLNDAFAELRKIIPTLPSDKLSKIQTLKLAARYIDFLYQVLQSDELDHKITSCNYLAHERLSYAFSVWRMEGAWSMSASH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U9L8</accession>
    <name>A0A8C2U9L8_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Solute carrier family 48 member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">SLC48A1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>heme b(in) = heme b(out)</text>
            <dbReference type="Rhea" id="RHEA:75443"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Phagosome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endosome membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HRG family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2U9L8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005034594.1">
        <property type="protein sequence ID" value="ENSCJPP00005025440.1"/>
        <property type="gene ID" value="ENSCJPG00005019962.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000002307"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome LGE22C19W28_E50C23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036019">
        <property type="term" value="C:endolysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061474">
        <property type="term" value="C:phagolysosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015232">
        <property type="term" value="F:heme transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030218">
        <property type="term" value="P:erythrocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097037">
        <property type="term" value="P:heme export"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140357">
        <property type="term" value="P:heme export from vacuole to cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042168">
        <property type="term" value="P:heme metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051674">
        <property type="term" value="P:localization of cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007041">
        <property type="term" value="P:lysosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006909">
        <property type="term" value="P:phagocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026218">
        <property type="entry name" value="HRG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31525">
        <property type="entry name" value="HEME TRANSPORTER HRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31525:SF1">
        <property type="entry name" value="HEME TRANSPORTER HRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16954">
        <property type="entry name" value="HRG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02095">
        <property type="entry name" value="TRNSPORTRHRG"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0967">Endosome</keyword>
    <keyword evidence="10" id="KW-0458">Lysosome</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00035075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005025440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="198" mass="21817" checksum="CC46FCB562C1CBD6" modified="2022-01-19" version="1">MAVSRALAVRLAYSAAGALMGFSAFFTWSLAPKFRQPATAAAGGLSGVLALWALITHVMYVQDYWRTWLKGLRFFLFIGILFSALSMVGFCTFLVLAITQHQSLTDPRSFYLSCVWSFISLKWAFLLSLYSYRCWMSELPPSAMAGGAVLIPADHRGVCKCFYTGCPNPSPTQHCPWVCCLAAVPSPISCCWSLPITE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UBR0</accession>
    <name>A0A8C2UBR0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Solute carrier family 25 member 25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">SLC25A25</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2UBR0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005034534.1">
        <property type="protein sequence ID" value="ENSCJPP00005025381.1"/>
        <property type="gene ID" value="ENSCJPG00005019853.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157207"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 17"/>
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        <property type="term" value="F:ATP:phosphate antiporter activity"/>
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        <property type="term" value="F:calcium ion binding"/>
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        <property type="term" value="P:adipose tissue development"/>
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        <property type="term" value="P:response to dietary excess"/>
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        <property type="entry name" value="calcium-binding mitochondrial carrier protein SCaMC-2 isoform X1"/>
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        <property type="entry name" value="Putative calcium-binding mitochondrial carrier protein scamc-2"/>
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        <property type="entry name" value="Putative calcium-binding mitochondrial carrier protein scamc-2"/>
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        <property type="entry name" value="EF-hand"/>
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        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="EF-hand-dom_pair"/>
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        <property type="entry name" value="GDC-like"/>
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        <property type="entry name" value="MCP"/>
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    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
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        <property type="entry name" value="MCP_transmembrane"/>
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        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
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    <dbReference type="PRINTS" id="PR00928">
        <property type="entry name" value="GRAVESDC"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <feature type="domain" description="EF-hand" evidence="15">
        <location>
            <begin position="47"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="15">
        <location>
            <begin position="114"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="13">
        <location>
            <begin position="232"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="13">
        <location>
            <begin position="326"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="13">
        <location>
            <begin position="423"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
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            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022692"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
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            <dbReference type="Ensembl" id="ENSCJPP00005025381.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="517" mass="57321" checksum="FBCF026EC96189CD" modified="2022-01-19" version="1">MPGARRSLASPVMSGVLCPCGSPRAAATPGPGSEGSPCGRAACEASEQDRRLRALFQKLDVNRDGALCIHDLAVGLGRLGLHRTELDLLKIVKAGDKDLDGQLDFEEFVHYLQDHEKKLRLVFKSLDKKNDGRIDAQEIVQSLRDLGVKISEEQAEKILKRIRTGHFWGPVTYMDKNGTMTIDWNEWRDYHLLHPVENIPEIILYWKHSTIFDVGENLTVPDEFTVEERQTGMWWRHLVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMCIIGGFTQMIREGGTRSLWRGNGINVLKIAPESAIKFMAYEQIKRFIGTDQEMLRIHERLLAGSLAGAIAQSSIYPMEVLKTRMALRKTGQYSGMLDCAKNILSKEGMAAFYKGYIPNMLGIIPYAGIDLAVYETLKNAWLQRYAVNSADPGVFVLLACGTISSTCGQLASYPLALVRTRMQAQASVEGAPEVTMRGLFKHILKTEGAFGLYRGLAPNFMKVIPAVSISYVVYENLKMTLGVQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UBV1</accession>
    <name>A0A8C2UBV1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Exosome complex exonuclease RRP44</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Protein DIS3 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">Ribosomal RNA-processing protein 44</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="primary">DIS3</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="28" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="28" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="20">Component of the RNA exosome complex; within the complex interacts with EXOSC4, EXOSC7 and EXOSC9 of the exosome core complex (Exo-9). The catalytically inactive RNA exosome core complex (Exo-9) associates with the catalytic subunit EXOSC10/RRP6. Exo-9 may associate with DIS3 to form the nucleolar exosome complex, or DIS3L to form the cytoplasmic exosome complex. Exo-9 is formed by a hexameric base ring consisting of the heterodimers EXOSC4-EXOSC9, EXOSC5-EXOSC8 and EXOSC6-EXOSC7, and a cap ring consisting of EXOSC1, EXOSC2 and EXOSC3; DIS3 associates with the base ring of Exo-9. The RNA exosome complex associates with cofactors C1D/RRP47, MPHOSPH6/MPP6 and MTREX/MTR4. Interacts with DHX34; the interaction is RNA-independent.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 24">Belongs to the RNR ribonuclease family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015707134.1">
        <property type="nucleotide sequence ID" value="XM_015851648.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UBV1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005033893.1">
        <property type="protein sequence ID" value="ENSCJPP00005024895.1"/>
        <property type="gene ID" value="ENSCJPG00005019586.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107308064"/>
    <dbReference type="KEGG" id="cjo:107308064"/>
    <dbReference type="CTD" id="22894"/>
    <dbReference type="GeneTree" id="ENSGT00530000063106"/>
    <dbReference type="OrthoDB" id="372421at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071034">
        <property type="term" value="P:CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071031">
        <property type="term" value="P:nuclear mRNA surveillance of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09862">
        <property type="entry name" value="PIN_Rrp44-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000010">
        <property type="entry name" value="Exosome complex exonuclease DIS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.700:FF:000001">
        <property type="entry name" value="Exosome complex exonuclease exoribonuclease (Rrp44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000125">
        <property type="entry name" value="exosome complex exonuclease RRP44 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.690:FF:000002">
        <property type="entry name" value="exosome complex exonuclease RRP44 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041505">
        <property type="entry name" value="Dis3_CSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022966">
        <property type="entry name" value="RNase_II/R_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033771">
        <property type="entry name" value="Rrp44_CSD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033770">
        <property type="entry name" value="RRP44_S1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF35">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RRP44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17849">
        <property type="entry name" value="OB_Dis3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17216">
        <property type="entry name" value="Rrp44_CSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17215">
        <property type="entry name" value="Rrp44_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01175">
        <property type="entry name" value="RIBONUCLEASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="14" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="13" id="KW-0271">Exosome</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="18" id="KW-0464">Manganese</keyword>
    <keyword evidence="10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="PIN" evidence="26">
        <location>
            <begin position="65"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="RNB" evidence="27">
        <location>
            <begin position="470"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="942"/>
            <end position="963"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005785"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
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    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00065106"/>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00077221"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00077930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="RuleBase" id="RU003901"/>
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    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="SMART" id="SM00670"/>
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    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="SMART" id="SM00955"/>
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    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005024895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="963" mass="109589" checksum="BD4CC2450C1235F2" modified="2022-01-19" version="1">MLTSRTFLKRTRAGAVVKVVREHYLRDDIPCGVEFCPLCPIRPGQPLGLEARPSGAASSLCRGPHYLLPDTNLLLHQIDILEDPVIKNVIVLQTVLQEVRSRSAPVYKRIRDVIGNPEKHFYSFTNEHHRETYIEQEQGESSNDRNDRAIRVAVKWYSEHLKKIQNEENEDIQVVFLTNDRNNKEKALEEGITAYTCEEYIKSLIDNPDLVDRLACVSDEGKEIESGKIIFPEHVPLSKLQQGIKSGIYLQGTYRASRDNYLEATVWVHGDGEENKEIIIQGLKHLNRAVHEDIVAVELLAKDEWVAPSSVVLQDDGQNEDDVETEEEKENILKVSVDKNMLRPTGKVVGIIKRNWRPFCGMLSKSQIKEARRHLFTPSDRRIPRIRIETRQADKLEGQRIIVAIDGWPRNSRYPNGHFVKNLGSAGDKETETEVLLLEHDVPHQPFSQNVLSFLPKMPWSITEKDMKHREDLRHLHVCSVDPPGCTDIDDALHCRELENGNLEVGVHIADVSHFIRPGNALDEESAKRGTTVYLCEKRIDMVPELLSSNLCSLRSNVDRLAFSCIWEMNQKADILKTRFTKSIINSKASLTYAEAQMRIDSAALNDDITVSLRGLNKLAKILKKKRIDNGALTLSSPEVRFHMDSETHDPIDLQTKELKETNSMVEEFMLLANVSVAQKIYDEFPEFALLRKHPAPPPSNYDILVKAAKSKNLEIKTDSAKALAESLDKAESPDFPYLNTLLRILTTRCMMQAVYFCSGMDSDFHHYGLASPIYTHFTSPIRRYADIIVHRLLAVAIGADRTYPELMDKHKLADLCKNLNYRHKMAQYAQRASVAFHTQLFFKTKGVVNEDAYILFIRRNAVVVLIPKYGLEGTVFFEEKDKPMPKLHYNSEVPSLTVEGTILCLFDKVKVNITLDASNIQHQKIRMELVEPKILASGVPAHLSTETSSNNEPEKKKKKLQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UG14</accession>
    <name>A0A8C2UG14_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Pre-mRNA-processing factor 40 homolog A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Formin-binding protein 11</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Formin-binding protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">PRPF40A</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. May play a role in cytokinesis. May be involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus matrix</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the PRPF40 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2UG14"/>
    <dbReference type="Ensembl" id="ENSCJPT00005035704.1">
        <property type="protein sequence ID" value="ENSCJPP00005026364.1"/>
        <property type="gene ID" value="ENSCJPG00005020508.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00930000150980"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.440:FF:000003">
        <property type="entry name" value="Pre-mRNA processing factor 40 homolog A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.440:FF:000002">
        <property type="entry name" value="pre-mRNA-processing factor 40 homolog A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.440:FF:000009">
        <property type="entry name" value="pre-mRNA-processing factor 40 homolog A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.440:FF:000011">
        <property type="entry name" value="pre-mRNA-processing factor 40 homolog A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.440:FF:000012">
        <property type="entry name" value="pre-mRNA-processing factor 40 homolog A isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000102">
        <property type="entry name" value="Pre-mRNA-processing factor 40 homolog B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000050">
        <property type="entry name" value="pre-mRNA-processing factor 40 homolog B isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.440">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002713">
        <property type="entry name" value="FF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036517">
        <property type="entry name" value="FF_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039726">
        <property type="entry name" value="Prp40-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11864:SF20">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 40 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11864">
        <property type="entry name" value="PRE-MRNA-PROCESSING PROTEIN PRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01846">
        <property type="entry name" value="FF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25432">
        <property type="entry name" value="FF_PRPF40A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00441">
        <property type="entry name" value="FF"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81698">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51676">
        <property type="entry name" value="FF"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="WW" evidence="19">
        <location>
            <begin position="168"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="19">
        <location>
            <begin position="208"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="20">
        <location>
            <begin position="375"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="20">
        <location>
            <begin position="442"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="20">
        <location>
            <begin position="509"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="20">
        <location>
            <begin position="589"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="20">
        <location>
            <begin position="654"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="20">
        <location>
            <begin position="724"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="305"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="785"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="428"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="560"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="18">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="305"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="789"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="849"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="865"/>
            <end position="898"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00057440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00061317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00072041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00078214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00080815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005026364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="940" mass="107245" checksum="2BD3B550CBB56DE4" modified="2022-01-19" version="1">MQLTPGDAVRPVASAADQSPKGSRLTGRPDWPAGKPVSLLAPLLPPRGEPEPLMPFGPTSRQPLRGRMMGRCGGGSLLSTAMRPGERSAIMMGHPGMPHYPPMGMHPMGQRPPNMPPVPHSMMPQMMPPMGGPPMGQMPGMMQSVMPGMMMSHMSQAAMQPTVPKSTWTEHKSPDGRTYYYNTETKQSTWEKPDDLKTPAEQLLSKCPWKEYKSDSGKPYYYNSQTKESRWAKPKELEDLEGNVGNKDEQRGCCYVLLGLNVIVPIFLTYSTKTEESASTTAAADAANTAATATAAAEAATAGTASTAAASETETTAASAAVENESAAAATAEEQSAESATNAADDSKQDGSADTSKKEGDDAQPVKKTYTWNTKEEAKQAFKELLKEKRVPSNASWEQAMKMIINDPRYSALAKLSEKKQAFNAYKVQTEKEEKEEARSKYKEAKESFQRFLENHEKMTSTTRYKKAEQMFGEMEVWNAISERDRLEIYEDVLFFLSKKEKEQAKQLRKRNWEALKNILDNMANVTYCTTWSEAQQYLMDNPTFAEDEELQNMDKEDALICFEEHIRALEKEEEEEKQKSLLRERRRQRKNRESFQIFLDELHEHGQLHSMSSWMELYPTISSDIRFTNMLGQPGSTALDLFKFYVEDLKARYHDEKKIIKDILKDKGFVVEVNTSFEDFVTVISSTKRATTLDAGNIKLAFNSLLEKAEAREREREKEEARKMKRKESAFKSMLKQATPPIELDAVWEDIRDRFVKEPAFEDITLESERKRIFKDFMHVLEHECQHHHSKNKKHSKKSKKHHRKRSRSRSGSESEDDDSHSKKKRQRSESRSASERSSSAESERSYKKSKKHKKKSKKRRHKSDSPESDIEREKDKKERERESEKDRARQRSESKHKSPTKKRPGKDSGNWDTSGSELSEGELEKQRRTLLEQLDEDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UGC7</accession>
    <name>A0A8C2UGC7_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ATP-binding cassette sub-family A member 10-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC107322188</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCA family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015735427.1">
        <property type="nucleotide sequence ID" value="XM_015879941.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005037090.1">
        <property type="protein sequence ID" value="ENSCJPP00005027435.1"/>
        <property type="gene ID" value="ENSCJPG00005021277.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107322188"/>
    <dbReference type="KEGG" id="cjo:107322188"/>
    <dbReference type="GeneTree" id="ENSGT00940000162673"/>
    <dbReference type="OrthoDB" id="8061355at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03263">
        <property type="entry name" value="ABC_subfamily_A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000335">
        <property type="entry name" value="ATP binding cassette subfamily A member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000436">
        <property type="entry name" value="ATP binding cassette subfamily A member 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056264">
        <property type="entry name" value="R2_ABCA1-4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF274">
        <property type="entry name" value="ABC-TYPE ORGANIC ANION TRANSPORTER ABCA8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12698">
        <property type="entry name" value="ABC2_membrane_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23321">
        <property type="entry name" value="R1_ABCA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="223"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="359"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="861"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1014"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1061"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1097"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1133"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1160"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1199"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="481"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1281"/>
            <end position="1525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="447"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005027435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1628" mass="184902" checksum="EACF72E1D49F4FBC" modified="2022-01-19" version="1">MRRLKRNLSVFQQTKILLWKNVLIKWRMKMQSFQEWMLSLLFLPLLFIVSSFMMYIPYPEAPRSLLGQLDDPAYNATGVTIAFTPDTAATRHIMNTVASKSVMAGIKLKALDTERALEEAWISNEEIIGVVFKSNFSYHLRFPYGNVFVPNENLEYIDTCYNYSASHCDSPRYWYRGFLSLQSSIDAAIIEVVANHSVWEEMRTISGVRMKSRSVISSITLEYSYFMITIVMCFSSFMYFSSVNVIREKKKLKVLMKLMGLHDMAFWLSWSLLYAIYVLILSCMLTALVVQETFYTSSFSAVLLLLFLYGLACVHLVFMLCSLLRTSKLVGSLGFLITFLFGCLSLSVLIENLPAPLKWFLSLFCPFTFNAGIAKIFSLERYRIGFSFSNLMEESYFLLSTYIMLIFDSVLYMLLAIYFDKVLQGKYGIPAPPLFCLKPSYWMRSRRGSPGEGHRGAGSPEENPGDNVEPMPLEFRGKEAIRLHNIKKTYKKKDKKTEALRGLSLNIYEGQITALLGHSGAGKTTLLNVLSGLTLPSEGSATIYDYKLSEIGDREEIREMVGVCPQFNTHFEVLTVKENLQTFAEIKGIKSKEVEQEVQNILELLDISSVQDTQAEKLSGGQKRKLSIGIAMLGNPQVLLLDEPTAGLDPLSRHQVWSLLKEHRAGRVILFSTQFMDEADILADRKAFISRGRLKCVGSSLFLKNKWGIGYHLRIHVSDSCVAENVTSLVKQYIPNVIFSGHGQYELRYKLPLENVNKFPDLFRGLDSCSGLGIINYGVSMTTLEDVFLRVEEAAVDQEDERVPGEWAEGGARSPEEMESGSLLLSDTGRMTVSSWALWRQQVSAMAWVHFLKLKSSVKNLLSILLLYVVFLLPLILQLALMAVWQSMSAWELCSSRYFLPLRTRAHADTTNLLVLNSTGSSIEDFIHALESQDLALEITSKENITEELKYNGAIKVSREGQSYRFTIFCHMEAINCFPVLVNIISNALLRAFNSTAHIQIWSHPFYYVDNTRYWDYFASFYLIYMLLLFPGFPPHFAMGYLQDYKTGARAQLRVSGLFPSAYWCGQALVDVPLCWLLLFSMFGLQFGMSNRVSGTFSSFFCLITCAFGYGISIIFFIYLISFLFRKGWNCDFWSFILIVVCLVTFIVSRIMDYIIDLEISLYLLSLLIPSYPALAVMLDSEQMFIEDSNLHVGFRNNNILIAVFAPYIHSVVFVFLLRYLEIKYERPVLRKDPVFRISPIKENSHQHLEEPEGEDEDVKAEREAVKNAIAAPSPEEKSVIIVSNLYKEYKIKKAGSIFRKKKKMATKNISFCVKKGEVLGLLGPNGAGKSTVIKMIAGETTLTAGQVLLRSRDATPCWPQDHVLAYLGHCPQEDPLWPDLTVHEHLKIYAAVKGLCKEDTATAINRLVNALELQDYLKKPTRKLPAGITRKLCFAVCMLGNPSVLLLDEPSTGMDPNGQRCIWEMIRAALKTQETGTVLTTHYMEEAEAVCDRVAILVAGQLRFIGSIQYLKNKFGKGYLLEIKVKDPESTDLLHAEILRIFPSAARQERFPSLLVYKVPMEDALPLSQSFSKLEEAKQNFNLEEYSFSLNTLAQVFLELSREQEKDNFDLTLDGPFEWKQLQQEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UH43</accession>
    <name>A0A8C2UH43_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Intraflagellar transport protein 122 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">IFT122</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2UH43"/>
    <dbReference type="Ensembl" id="ENSCJPT00005036295.1">
        <property type="protein sequence ID" value="ENSCJPP00005026796.1"/>
        <property type="gene ID" value="ENSCJPG00005020797.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000001016"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030991">
        <property type="term" value="C:intraciliary transport particle A"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097730">
        <property type="term" value="C:non-motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035721">
        <property type="term" value="P:intraciliary retrograde transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061512">
        <property type="term" value="P:protein localization to cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000003">
        <property type="entry name" value="intraflagellar transport protein 122 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000005">
        <property type="entry name" value="Intraflagellar transport protein 122 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056153">
        <property type="entry name" value="Beta-prop_IFT122_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056152">
        <property type="entry name" value="Beta-prop_IFT122_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039857">
        <property type="entry name" value="Ift122/121"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057411">
        <property type="entry name" value="TPR_IFT122"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056838">
        <property type="entry name" value="Zn_ribbon_IFT122"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12764:SF4">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 122 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12764">
        <property type="entry name" value="WD REPEAT DOMAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23381">
        <property type="entry name" value="Beta-prop_IFT122_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23377">
        <property type="entry name" value="Beta-prop_IFT122_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25295">
        <property type="entry name" value="TPR_IFT122"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25144">
        <property type="entry name" value="Zn_ribbon_IFT122"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25143">
        <property type="entry name" value="Zn_ribbon_IFT122_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="7" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="IFT122 first beta-propeller" evidence="14">
        <location>
            <begin position="10"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="38"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="IFT122 second beta-propeller" evidence="13">
        <location>
            <begin position="344"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="Intraflagellar transport protein 122 homolog TPR" evidence="16">
        <location>
            <begin position="605"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="domain" description="IFT122 zinc ribbon" evidence="15">
        <location>
            <begin position="1036"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="189"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF23381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF25144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF25295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005026796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1227" mass="140711" checksum="35571A29B718940C" modified="2022-01-19" version="1">MRAALTWRDRPDGTQLIIAAGNRLLVYDTSDGTLIQPLKGHKDTVYCVAYAKDGKRFASGSADKSVIIWTSKLEGILKYTHNDSIQCVSYNPLTHQLASCSSSDFGLWSPEQKSVSKHKASSRITCCSWTNDGQYLALGMFNGVISIRNKNGDEKVKIERTGAGSSPIWSICWNPSSRWETFWSRADEEDSDNGHLEKSDNSQLEEIPELKPKPGSGQDNEEKVEDNEKEEAMHFNERNDTLAVADWGQRLSFYQLSGKQIGKDRMLNFDPCCVSYFTKGEYLLLGGSDKQVSLFTKDGVRLGTIGEQSSWVWTCKAKPDSNYVVMGCQDGTISFYQLIFSTVHGLYKDRYAYRDSMTDVIVQHLITEQKVRIKGRELVKKIAIYKNRLAIQMPEKILIYELYSDDSSDMYYRVKEKIVKKFECNLLVVCSDHIILCQEKRLQCLSFSGVKEREWLMESLIRYIKVIGGPPGREGLLVGLKNGQILKIFVDNVFAIVLLKQSTAVRCLDMSASRNKLAVVDENDTCLVYDIHTKELLFQEPNANSVAWNTQCEDMLCFSGGGYLNIKAGNFPVHQQKLQGFVVGYNGSKIFCLHVFSMSAVEVPQSAPMYQYLERKMFKEAYQIACLGVTDADWRELAMEALEGLEFETAKKAFTRIRDLRYLELISSIEERKKHGENLNELFLADVYAYQGKFHEAAKLYKKSGHESVALDMYSDLRMFDYAKDFLRSGDPKDTKMLIKKQADWAKNINEPKAAVEMYLSAGEHMKAIEISGDHGWVDMLIEIARKLDKAEREPLSKCAFYFKKLNNPGYAAETYMKVGDLKALVSLHVETHRWEEAFAVSEKHPEFKDEVYVPYAQWLAENDRFEEAQKAFHKAGRQREAVRVLEQLTHNAVVESRFNDAAYYYWMLSMQCLDIAQEQQTEMLQKFHHFQQLAEIYHVYHYIQRYTEEPFSFHLPETLFNISRFLLHSLTKETPLGISKVNTLFALAKQSKALGAYKLARHAYDKLQGLQIPARFQKSVELGSLTIRSKPFHDSEELVPLCYRCSTNNPLLNNLGNVCVNCRQPFVFSASSYEVLHLVEFYLEDGITDEEAVSLIDLEAPRLNKSRNKWQEMMNAQSLRLNDSTVIIEDDDPFTAKLSFEQGGSEFVPVIVNRAVLQSMSRRDVLIKRWPKPLRWQYYRSLLPDASITMCPSCFQMFHTEDYELLVLQHNCCPFCRRRIDDSPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UHH3</accession>
    <name>A0A8C2UHH3_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Repulsive guidance molecule BMP co-receptor a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">RGMA</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the repulsive guidance molecule (RGM) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015728628.1">
        <property type="nucleotide sequence ID" value="XM_015873142.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UHH3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005035859.1">
        <property type="protein sequence ID" value="ENSCJPP00005026494.1"/>
        <property type="gene ID" value="ENSCJPG00005020589.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107318854"/>
    <dbReference type="KEGG" id="cjo:107318854"/>
    <dbReference type="CTD" id="56963"/>
    <dbReference type="GeneTree" id="ENSGT00950000183112"/>
    <dbReference type="OrthoDB" id="10013795at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015026">
        <property type="term" value="F:coreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990459">
        <property type="term" value="F:transferrin receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030509">
        <property type="term" value="P:BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006509">
        <property type="term" value="P:membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010977">
        <property type="term" value="P:negative regulation of neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001843">
        <property type="term" value="P:neural tube closure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051044">
        <property type="term" value="P:positive regulation of membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030510">
        <property type="term" value="P:regulation of BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1000.10:FF:000001">
        <property type="entry name" value="Repulsive guidance molecule BMP co-receptor a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.10">
        <property type="entry name" value="Mog1/PsbP, alpha/beta/alpha sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040287">
        <property type="entry name" value="RGM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009496">
        <property type="entry name" value="RGM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010536">
        <property type="entry name" value="RGM_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31428:SF4">
        <property type="entry name" value="REPULSIVE GUIDANCE MOLECULE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31428">
        <property type="entry name" value="RGM DOMAIN FAMILY MEMBER DRAG-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06534">
        <property type="entry name" value="RGM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06535">
        <property type="entry name" value="RGM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Repulsive guidance molecule N-terminal" evidence="13">
        <location>
            <begin position="48"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Repulsive guidance molecule C-terminal" evidence="12">
        <location>
            <begin position="158"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF06534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005026494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="450" mass="49814" checksum="69975F25F06AC738" modified="2022-01-19" version="1">MRPLRERIVVKAQAGWMGMGRGAGSTALGLFQILPVFLCIFPPVTSPCKILKCNSEFWAATSGSHHLGAEETPEFCTALRAYAHCTRRTARTCRGDLAYHSAVHGIDDLMVQHNCSKDGPTSQPRLRTLPPGDSQERSDSPEICHYEKSFHKHSAAPNYTHCGLFGDPHLRTFTDTFQTCKVQGAWPLIDNNYLNVQVTNTPVLPGSSATATSKLTIIFKSFQECVEQKVYQAEMDELPAAFADGSKNGGDKHGANSLKITEKVSGQHIEIQAKYIGTTIVVRQVGRYLTFAVRMPEEVVNAVEDRDSQGLYLCLRGCPVNQQIDFQTFRLAQAAEGRARRKGPSLPAPPEAFTYESATAKCREKLPVEDLYFQSCVFDLLTTGDVNFMLAAYYAFEDVKLLHSNKDKLHLYERTRALAPGNAAPSEHPWALSALWVALLSLSQCWLGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UI90</accession>
    <name>A0A8C2UI90_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Voltage-dependent R-type calcium channel subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">CACNA1E</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="19">Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 19">Membrane</location>
            <topology evidence="1 19">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSCJPT00005037355.1">
        <property type="protein sequence ID" value="ENSCJPP00005027669.1"/>
        <property type="gene ID" value="ENSCJPG00005021390.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155601"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008331">
        <property type="term" value="F:high voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000001">
        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000063">
        <property type="entry name" value="Voltage-dependent N-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="1.20.120.350:FF:000011">
        <property type="entry name" value="Voltage-dependent N-type calcium channel subunit alpha"/>
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    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000013">
        <property type="entry name" value="Voltage-dependent N-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Voltage-dependent R-type calcium channel subunit alpha"/>
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        <property type="match status" value="4"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
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        <property type="entry name" value="GPHH_dom"/>
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        <property type="entry name" value="Ion_trans_dom"/>
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        <property type="entry name" value="VDCC_alpha-1_subunit"/>
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    <dbReference type="InterPro" id="IPR005449">
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    <dbReference type="InterPro" id="IPR002077">
        <property type="entry name" value="VDCCAlpha1"/>
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    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628:SF5">
        <property type="entry name" value="VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ca_chan_IQ"/>
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        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00167">
        <property type="entry name" value="CACHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01633">
        <property type="entry name" value="RVDCCALPHA1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01062">
        <property type="entry name" value="Ca_chan_IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="EF_HAND_2"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 18 19" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 19" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="4 19" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16" id="KW-0407">Ion channel</keyword>
    <keyword evidence="12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="10 19" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
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            <begin position="133"/>
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    </feature>
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        </source>
    </evidence>
    <sequence length="2268" mass="256425" checksum="89D664C1932B3C61" modified="2022-01-19" version="1">MARFGEAVAGRLGSGDGGSEQNRSRQGAAAPAGGSPGAFKQTKAQRARTMALYNPIPVKQNCFTVNRSLFLFGEDNIVRKYAKKLIDWPYPFCTPLRAPPCSPCPDLPWWLHRTRVQKQPAGKRLPSEKTEPYFIGIFCFEAGIKIVALGFVFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNTHVDLRTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHRACYTNNSGELEELDPPHPCGVQGCPPGYECREWIGPNDGITQFDNILFAVLTVFQCITMEGWTTVLYNTNDALGATWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERERVENRRAFMKLRRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTSALEVLRRATIKRNRTDAMNRDSSDEHCVDISSVGERRLARSGLKGVDGASYLRHKERLLRISVRHMVKSQVFYWIVLSLVALNTACVAIVHHNQPAWLTHFLYYAEFLFLGLFLLEMSLKMYGMGPRLYFHSSFNCFDCGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGGFNFIDGTPSANFDTFPAAIMTVFQILTGEDWNEVMYNGIRSQGGVRSGMWSSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAFNQKHALQKAKEVSPMSAPNMPAIERDRRRRHHMSMWEPRSSHLRERRRRHHMSVWEQRTSQLRRHMQMSSQEGINKDEPPLINPHASIFRRKKPGDGVALEKCDEEQGGKGERPPAEGPEQPAPGTNPGGGEDRKSPSPRARRDKEMWQHKVCHGNCEPGEEGAGGGIEERARMRQSQRRSRHRKARMEGKEPTGALESRAGSQETGLEEPCPAEGMQDGEQHGDSAAALDLIQGELEASGDTTRLSLYHSPEPPRGMESSLGEQDCSSPDTSEQALLGGAALGASRTVSHSEPDLSSVTANTEKATESTTIMIDVQDSTVVQISNKTDGEASPLKEAESKEDEEQMEKKKRKKEKSETGKAMVPHSSMFIFSTTNPVRRACHYIVNLRYFEMCILLVIAASSIALAAEDPVLTNSDRNKVLRYFDYVFTGVFTFEMVIKMIDQGLILQDGSYFRDLWNILDFIVVVGALVAFALATNKGRDIKTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYKLFMFIFAVIAVQLFKGKFFYCTDSSKDTEKDCIGNYVDHEKNKMEVKCREWKRHEFHYDNIIWALLTLFTVSTGEGWPQVLQHSVDVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEECSLEKNERACIDFAISAKPLTRYMPQNRHTFQYRVWHFVVSPSFEYTIMAMIALNTVVLMMKYYSAPYTYELALKYLNIAFTMVFSLECVLKIIAFGFLNYFRDTWNIFDFITVIGSITEIILTDTKLVNTSSFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLDEESHINRHNNFRSFLGSLMLLFRSATGEAWQEIMLSCLEGKGCEPDTTATSGQNENERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEFVRIWAEYDRAACGRIHYTEMYEMLTLMSPPLGLGKRCPSKVAYKRLVLMNMPVAEDMTVHFTSTLMALIRTALDIKIAKGGADWQQLDSELQKEILTIWPHLSQKMLDLLVPMPKTSDLTVGKIYAAMMIMDYYKQSKAKKQRQQLEEQKNAPMFQRMEPSSLPQEIISNAKALPYLQQETLTGLSSRSGFPSLSPLSPQEIFQLACMDPSHGQFQEHQSLEPEVREFQRVQPSNRGSYLPVDTQDHAVSGRASSMPRLTVDPQVVTDTSSMRRSFSTIRDKRTNTSWLDEFSMERSSENTYKSRRRSYHSSLQLSARRLNADSGHRSEGHRSGGRERGRSKERKHLLSPDISRCNSEERSPQAHDESPERRRESRSPSEGRSQTPNRQGTGSLSESSIPSISDTSTPRRGRRQLPPVPPKPRPLLSYASMLRHAAGDASPPPDETEGGSPLLSKEPNTAGLTESSSSPAGKPSRPSTPQRYISEPYLALHDDSHASDCGEEETLTFEAAVATSLGRSNTIGSAPPLRHSWQMPNGHYRRRRRGAGQGVMCGASIDVLSDTEEDDKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UJ48</accession>
    <name>A0A8C2UJ48_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Vav guanine nucleotide exchange factor 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">VAV3</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UJ48"/>
    <dbReference type="Ensembl" id="ENSCJPT00005036754.1">
        <property type="protein sequence ID" value="ENSCJPP00005027139.1"/>
        <property type="gene ID" value="ENSCJPG00005020974.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155252"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001772">
        <property type="term" value="C:immunological synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005154">
        <property type="term" value="F:epidermal growth factor receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050853">
        <property type="term" value="P:B cell receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030032">
        <property type="term" value="P:lamellipodium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030593">
        <property type="term" value="P:neutrophil chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030890">
        <property type="term" value="P:positive regulation of B cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045785">
        <property type="term" value="P:positive regulation of cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051897">
        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009410">
        <property type="term" value="P:response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd20869">
        <property type="entry name" value="C1_VAV3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21264">
        <property type="entry name" value="CH_VAV3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01223">
        <property type="entry name" value="PH_Vav"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11981">
        <property type="entry name" value="SH3_VAV3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11978">
        <property type="entry name" value="SH3_VAV3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.900.10:FF:000009">
        <property type="entry name" value="Vav guanine nucleotide exchange factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000015">
        <property type="entry name" value="Vav guanine nucleotide exchange factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000019">
        <property type="entry name" value="Vav guanine nucleotide exchange factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000050">
        <property type="entry name" value="Vav guanine nucleotide exchange factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000024">
        <property type="entry name" value="Vav guanine nucleotide exchange factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000039">
        <property type="entry name" value="Vav guanine nucleotide exchange factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022613">
        <property type="entry name" value="CH_CAMSAP_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037832">
        <property type="entry name" value="PH_Vav"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003096">
        <property type="entry name" value="SM22_calponin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055251">
        <property type="entry name" value="SOS1_NGEF_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047015">
        <property type="entry name" value="VAV3_SH3_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035734">
        <property type="entry name" value="VAV3_SH3_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45818:SF1">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR VAV3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45818">
        <property type="entry name" value="PROTEIN VAV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11971">
        <property type="entry name" value="CAMSAP_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22697">
        <property type="entry name" value="SOS1_NGEF_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00888">
        <property type="entry name" value="SM22CALPONIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 9" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="1 10" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="15">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="14">
        <location>
            <begin position="192"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="13">
        <location>
            <begin position="400"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="16">
        <location>
            <begin position="513"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="12">
        <location>
            <begin position="579"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="11">
        <location>
            <begin position="658"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="12">
        <location>
            <begin position="774"/>
            <end position="833"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005027139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="833" mass="96424" checksum="1E0A6D8BDE124BAD" modified="2022-01-19" version="1">MEPWKQCGQWLISCKVLPPNHRVTWDTAQVFDLAQTLRDGVLLCQLLNNLRSHSINLKEINLRPQMSQFLCLKNIRTFLSACCEIFGMKKSELFEAFDLFDVRDFGKVIETLSKLSRTPIAIGTGIRPFPTEESIDDEDIYKCLPDLIDETGIDEDEELYDCVYGEDEGGEVYEDLMKDEAAQQPKHTENDVRSCCLAEIKQTEEKYTETLESIEKFFMVPLKRFLSASEFETVFINIPDLVKIHRSLTQDISDSIINKNDQNLYQIFINYKERLVIYGQYCSQVETAISCLDNISKTKEDVKLKLEECSKRANNGKFTLRDLLVVPMQRVLKYHLLLQELVKHTTDPMEKANLRLALDAMKDLAQYVNEVKRDNETLREIRQFQLSIENLNHSLLQYGRPQGDGEIRITTLDKRARQDRHIFLFDLAVIVCKRRGDNYEMKEIIDLQKYKITNNPTTDKENKKWSYGFYLIHIQGQNGLEVYCKTKDLKKKWLEQFQMALSNIRPDYADTSFHEFKMHTFSRVTSCKVCQMLLRGTFYQGYLCSKCGAGAHKECLGRLDNCGRKRTNGIRRNSRHVDPGLPRMQVIRNYKGIPQPAPQDGPPLHIQIGDTIELITGDAHSLFWQGRNLTTGELGFFPSDAVKPSPCVYNFCCSLCYRFAGAMERLQAESELINRVNSTYLVRHRTKESGEYAISIKYNNEVKHIKILTRDGYFHIAENRKFKNLMELVDYYKHHSLKEGFRSLDTTLQFPYKESENSVGQRGNRAGGNLLSPKVIGIAIARYDFCARDMRELSLLKGDVVKIYTKMSANGWWRGEVNGRVGWFPSTYVEEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UKS0</accession>
    <name>A0A8C2UKS0_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Niban apoptosis regulator 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">NIBAN1</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Niban family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015725322.1">
        <property type="nucleotide sequence ID" value="XM_015869836.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UKS0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005037469.1">
        <property type="protein sequence ID" value="ENSCJPP00005027775.1"/>
        <property type="gene ID" value="ENSCJPG00005021478.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107317308"/>
    <dbReference type="KEGG" id="cjo:107317308"/>
    <dbReference type="CTD" id="116496"/>
    <dbReference type="GeneTree" id="ENSGT00940000154149"/>
    <dbReference type="OrthoDB" id="9010513at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd23949">
        <property type="entry name" value="Niban-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026088">
        <property type="entry name" value="Niban-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059060">
        <property type="entry name" value="Niban_1/2/3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14392">
        <property type="entry name" value="NIBAN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14392:SF3">
        <property type="entry name" value="PROTEIN NIBAN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26086">
        <property type="entry name" value="Niban2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26089">
        <property type="entry name" value="PH_Niban2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Niban 1/2/3" evidence="3">
        <location>
            <begin position="337"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="584"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="689"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="911"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="951"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1048"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="584"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="697"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="719"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="790"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="825"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="915"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="951"/>
            <end position="993"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005027775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1106" mass="124553" checksum="68D73D7077A3A1B9" modified="2022-01-19" version="1">MGGSASGPLDDSKCAYIRGKTEAIIKNFSPHYKHQYAVAFCKHVQDELEQHRNSQSQFLKTRPKSEAGTVLYETELLHFAEDVKKWKDRYVVIKNDYTVDCFETKEAYQKGLSPKHHLVPAGGKVLTLEEDYNLLSDKHFPDPVGLCGKETAQAFVQLPREFPVYLWQPFTRHSYYCFQEPEAQRQFSAVLSDCVRHSNYDFLKQTTYEVEAFLEAIQFFRQEKGHYGTWEMITGNEKEILSNLVMEELLPNLQTMILPKMKGKRNDRKRAWFGFVEEAYGLVQQQVAEGLSTLKEECRDFAKTLEGTIRSDMDQILSSKSFLAGKIKAAVSEPAQKCCAENIQPFLTSILEELMGPVSSGFTEVRSLFDKEVNEIIQNFQKTNDLTKLKEDVDQLMNLPFNSLKMEPSYVKVNLLQELLHDLKSRFKVYHIDFVVQRTQNFMQELMENAVYTFEQLFSPSRQADPVKVTTTLEKVKQRVLKQYDYDSSTIRKKIFQEALVQITLPTMQKTLASTCKPELQKYEQFIFADYTSVIQVENVYEEILYQMLLEETLKVIKEAAVLKKHNLFEDNLNLPCESVSSLTDLKTPSGSAQTTPAKKPSTIRMEASDTETQSEETLIVTEKILWEKDHEDRKPSDREADVNVDGRQARKSEEVVITDISEKWESLPTTAVKQEFAEGNTSLENESMVKADSVGDTEKKLKTREEAGEEEVASETENTLRDVSPEQELKVHEGAVEEKVTSEKESKEQEEGAEIELTSPPNKTAETEVLGSAEMKIKIEEGVAEEPSQNEKDSKEKSKDQGASMEISVASQDEHTGKGASGDNPDKESKSEVKNSEPLDDVNEIRNLLMVTVELPADTPPEKVKEICEAETLKLQEYEGNTEISKTAAVDVKVCEMMVNKDATECMEFKENKPSSSSCGTNGTSIGNVSKVGRGVAQAEWLVEISDTPQEVKSEVEIKQSMCHKDAGSCDSDRLHPEEHTENASEDKRLSGEEGGAENSHAGLVEAETESFFHKPAENPDATQVPIVNTEEPRTGLVDVPFLLVAEPDKESAVQVTAGAELGESEGKPEDESSSSHVEIKSSEVNNVFTQENREDSSVQQSPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y553</accession>
    <name>A0A8C2Y553_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Neuronal PAS domain protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">NPAS2</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y553"/>
    <dbReference type="Ensembl" id="ENSCJPT00005002097.1">
        <property type="protein sequence ID" value="ENSCJPP00005001224.1"/>
        <property type="gene ID" value="ENSCJPG00005001288.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160744"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990513">
        <property type="term" value="C:CLOCK-BMAL transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032922">
        <property type="term" value="P:circadian regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045739">
        <property type="term" value="P:positive regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051775">
        <property type="term" value="P:response to redox state"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd19737">
        <property type="entry name" value="bHLH-PAS_NPAS2_PASD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000016">
        <property type="entry name" value="Circadian locomoter output cycles protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000022">
        <property type="entry name" value="circadian locomoter output cycles protein kaput"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000013">
        <property type="entry name" value="Circadian locomoter output cycles protein kaput"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047230">
        <property type="entry name" value="CLOCK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001067">
        <property type="entry name" value="Nuc_translocat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46055">
        <property type="entry name" value="CIRCADIAN LOCOMOTER OUTPUT CYCLES PROTEIN KAPUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46055:SF1">
        <property type="entry name" value="NEURONAL PAS DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14598">
        <property type="entry name" value="PAS_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00785">
        <property type="entry name" value="NCTRNSLOCATR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
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    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="110"/>
            <end position="160"/>
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            <begin position="506"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
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    </evidence>
    <sequence length="915" mass="101072" checksum="230CEE05BBD24A3B" modified="2022-01-19" version="1">MRHGTGPGTGSEAGGVPGSSAATKSLPAPEPGLLRAWSSGGRCRSGTGRQRRSGGIQPGGTGTQVATADSSSGGGGGGGGWGFPAELPQHRQPRKNCLDNLMDEDEKDRAKRASRNKSEKKRRDQFNVLIKELSSMLPGNTRKMDKTTVLEKVIGFLQKHNEVSAQTEISEIQQDWKPSFLSNEEFTQLMLEALDGFIIAVTTGGSIIYVSDSITPLLGHLPCDVLDQNLLNFLPEQEHSEIYKMLSSCMLMTDSASSDYLKTDNELEFYCHLLRGSLNPKEFPTYEYIKFVGNFRSYSNVPNSTCNGFDEAVPRAYRASPGKQICFVATVRLATPQFLKEMCIVEEPLEEFTSRHSLEWKFLFLDHRAPPIIGYLPFEVLGTSGYDYYHIDDLELLARCHEHLMQFGKGKSCYYRFLTKGQQWIWLQTHYYITYHQWNSKPEFIVCTHMVVSYADVRVERRQEMGLEEVSSEVVSSALKDSGSSLDPEQHFNTLDIGASILSASRTPSVSSRSSPKSSHTPKSDPASTPTKLTAEASTPLQRTSSTQQDLASHRLSQSTALQAPLPSQPSCELLPQQLLPQATLQSQPAPLAQFSAQFSMFQTIKDQLEQRTRILQANIRWQQEELQKIQEQLCLVQDSSVQMFLQQPAVSLSFSNIQQPEPQPLQQRSGVISQQQLVPSPQLPGQIASPQTPSQQVLREASVISSQGPKAERNTELTTGSSRPTRSTATLFGPSTPLSRRGPGPSSGPSASAAGCSHDQQLRLLLSQPIQPMMPTSCNARHPSDLSMAGSQAKYSQNQQMFPSLEVQTSSSGSPIVLMGQAVLNQGFATTPPSQSSSLPPMQLQHQQHQQQRYLQVQTPSSLHNEQTDSLLLPSYSPQQGNMGYHQTQQQQQQQLPRRSNSLSESSDLSQPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y5A4</accession>
    <name>A0A8C2Y5A4_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Anion exchange protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">SLC4A4</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 hydrogencarbonate(out) + Na(+)(out) = 2 hydrogencarbonate(in) + Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:72215"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>3 hydrogencarbonate(out) + Na(+)(out) = 3 hydrogencarbonate(in) + Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:72219"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Basolateral cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Membrane</location>
            <topology evidence="15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the anion exchanger (TC 2.A.31) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y5A4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005002561.1">
        <property type="protein sequence ID" value="ENSCJPP00005001548.1"/>
        <property type="gene ID" value="ENSCJPG00005001554.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156290"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008509">
        <property type="term" value="F:monoatomic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008510">
        <property type="term" value="F:sodium:bicarbonate symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005452">
        <property type="term" value="F:solute:inorganic anion antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045821">
        <property type="term" value="P:positive regulation of glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.570:FF:000001">
        <property type="entry name" value="Anion exchange protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.930.10:FF:000002">
        <property type="entry name" value="Anion exchange protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.570">
        <property type="entry name" value="Helical hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.930.10">
        <property type="entry name" value="Mannitol-specific EII, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013769">
        <property type="entry name" value="Band3_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011531">
        <property type="entry name" value="HCO3_transpt-like_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003020">
        <property type="entry name" value="HCO3_transpt_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003024">
        <property type="entry name" value="Na/HCO3_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016152">
        <property type="entry name" value="PTrfase/Anion_transptr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00834">
        <property type="entry name" value="ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453">
        <property type="entry name" value="ANION EXCHANGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453:SF10">
        <property type="entry name" value="ELECTROGENIC SODIUM BICARBONATE COTRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07565">
        <property type="entry name" value="Band_3_cyto"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00955">
        <property type="entry name" value="HCO3_cotransp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01231">
        <property type="entry name" value="HCO3TRNSPORT"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01232">
        <property type="entry name" value="NAHCO3TRSPRT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55804">
        <property type="entry name" value="Phoshotransferase/anion transport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0915">Sodium</keyword>
    <keyword evidence="11" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="6" id="KW-0769">Symport</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="627"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="661"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="710"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="740"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="848"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="886"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="934"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="974"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1034"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1060"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1111"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="domain" description="Band 3 cytoplasmic" evidence="18">
        <location>
            <begin position="241"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="17">
        <location>
            <begin position="598"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="174"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1168"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="174"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1218"/>
            <end position="1235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010993"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00035820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00036309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF07565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005001548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1235" mass="139503" checksum="489C4C92C139773F" modified="2022-01-19" version="1">MLPKFVWRICAANRHWAEAAGCAGVVARVHVLVLREWSKCWSMLQVKMQELCRAIKCVWLMFGLETQPYLFQMFSLVFIANSYCAALGEKKKVIGVCLHNTYMQASAALMMLKDLMKNLSFRGRLLCHGRMLCWMEDEAVLDRGASFLKHVCDEEEVEGHHTVYIGVHVPKSYRRRRRHRRRTGHKEKKEKEKISENYSDKSDVENADETSSSILKPLISPAAERVRFILGEDDDSPAPPQLFTELDELLAVDGQEMEWKETARWIKFEEKVEQGGERWSKPHVATLSLHSLFELRTCIEKGSIMLDMEATSLPQVVEMIVDHQIETGLLKPDMKDKVTYTLLRKHRHQTKKSNLRSLADIGKTVSSATRSPLESSVPCLATRTLDDEIQVQRSPSVGWLSSPAMTHRNLTSTSLNDISDKPEKDQLKNKFMKKLPRDAEASNVLVGEVDFLDSPFIAFVRLQQAVMLGALTEVPVPTRFLFILLGPKGKAKSYHEIGRAIATLMSDEVFHDIAYKAKDWQDLIAGIDEFLDEVIVLPPGEWDPAIRIEPPKSLPSSDKRKNMYSGGENVQMNGDTPHDGGHGGGGHGDCEELQRTGRFCGGLIKDIKRKAPFFASDFYDALNIQSLSAILFIYLATVTNAITFGGLLGDATENMQGVLESFLGTAVTGAIFCLFAGQPLTILSSTGPVLVFERLLFNFSKDNDFDYLEFRLWIGLWSAFQCLILVATDASFLVKYFTRFTEEGFSSLISFIFIYDAFKKMIKLADYYPINPNFNVDYITRYYCACEPQFPDSSLLFNGTTVPSVEGPFYSSTEMYNTSIDWSSLTKKECFKYGGRLVGNNCGYVPDITLMSFILFFGTYTCSMALKKFKTSRYFPTTARKLISDFAIILSILIFCGLDALVGVATPKLIVPSEFKPTSPERGWFIPPFGGNPWWVYLAAAIPALLVTILIFMDQQITAVIVNRKEHKLKKGAGYHLDLFWVAILMIICSFMGLPWYVAATVISIAHIDSLKMETETSAPGEQPKFLGVREQRVTGVIVFILTGVSVFMAPILKFIPMPVLYGVFLYMGVASLNGVQFMDRLKLLLMPLKHQPDFIYLRHVPLRRVHLFTFLQVVCLALLWILKSTVAAIIFPVMILALVAVRKAMDYLFSQHDLSFLDDVIPEKDKKKKEDEKKKKKKKGSLDSDNEDSDCPYSEKVPSIKIPMDIMEQEPFLSDSKPADKEKSPTFLERHTSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y5L6</accession>
    <name>A0A8C2Y5L6_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synaptophysin/synaptobrevin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y5L6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005002714.1">
        <property type="protein sequence ID" value="ENSCJPP00005001609.1"/>
        <property type="gene ID" value="ENSCJPG00005001654.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234637"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001285">
        <property type="entry name" value="Synaptophysin/porin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10306">
        <property type="entry name" value="SYNAPTOPHYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10306:SF9">
        <property type="entry name" value="SYNAPTOPHYSIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51225">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="9">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005001609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="141" mass="14808" checksum="EC33A0C03C5A9306" modified="2022-01-19" version="1">LKPSPSALCGPPLPSPPPSYLRGDFSPSARFFVTVAVLAFLYSAAAIVAYLGWMTPPNPHFPPYFPPQDLAVTALLAFLWLCSSSAWGKALTDIHSSVGSPLPHCSPPNVTCVPGDVTSMRSLSVSVVRPHSFGGLYGAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y5M3</accession>
    <name>A0A8C2Y5M3_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y5M3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005002806.1">
        <property type="protein sequence ID" value="ENSCJPP00005001657.1"/>
        <property type="gene ID" value="ENSCJPG00005001707.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005001657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="97" mass="10237" checksum="00A670F26F7BCDD7" modified="2022-01-19" version="1">DLPAAGSAGTGRAASAQPPLCSRCTLCWVCEALCLSICAFLPFYYAPGKGSSFLFDDLPPASSSDAGERLCWLCWPDLPSLFITNLLAAGLCVVLKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y603</accession>
    <name>A0A8C2Y603_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">small monomeric GTPase</fullName>
            <ecNumber evidence="3">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">KRAS</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="3"/>
    <dbReference type="RefSeq" id="XP_015724699.1">
        <property type="nucleotide sequence ID" value="XM_015869213.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015724708.1">
        <property type="nucleotide sequence ID" value="XM_015869222.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y603"/>
    <dbReference type="SMR" id="A0A8C2Y603"/>
    <dbReference type="Ensembl" id="ENSCJPT00005005466.1">
        <property type="protein sequence ID" value="ENSCJPP00005003025.1"/>
        <property type="gene ID" value="ENSCJPG00005003266.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107317023"/>
    <dbReference type="KEGG" id="cjo:107317023"/>
    <dbReference type="CTD" id="3845"/>
    <dbReference type="GeneTree" id="ENSGT00940000155871"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060441">
        <property type="term" value="P:epithelial tube branching involved in lung morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021897">
        <property type="term" value="P:forebrain astrocyte development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014009">
        <property type="term" value="P:glial cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048873">
        <property type="term" value="P:homeostasis of number of cells within a tissue"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030857">
        <property type="term" value="P:negative regulation of epithelial cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043524">
        <property type="term" value="P:negative regulation of neuron apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051402">
        <property type="term" value="P:neuron apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060252">
        <property type="term" value="P:positive regulation of glial cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035022">
        <property type="term" value="P:positive regulation of Rac protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016601">
        <property type="term" value="P:Rac protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048169">
        <property type="term" value="P:regulation of long-term neuronal synaptic plasticity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032228">
        <property type="term" value="P:regulation of synaptic transmission, GABAergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035914">
        <property type="term" value="P:skeletal muscle cell differentiation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051146">
        <property type="term" value="P:striated muscle cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008542">
        <property type="term" value="P:visual learning"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd04138">
        <property type="entry name" value="H_N_K_Ras_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="KRAS proto-oncogene, GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
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    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005003025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="189" mass="21660" checksum="8A90D0C2E10CF6E1" modified="2022-01-19" version="1">MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRVKKISKEEKTPGCMKIKKCLVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y688</accession>
    <name>A0A8C2Y688_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Keratin 80</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">KRT80</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y688"/>
    <dbReference type="Ensembl" id="ENSCJPT00005006244.1">
        <property type="protein sequence ID" value="ENSCJPP00005003541.1"/>
        <property type="gene ID" value="ENSCJPG00005003693.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107325786"/>
    <dbReference type="GeneTree" id="ENSGT00940000161279"/>
    <dbReference type="OrthoDB" id="2441647at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome LGE22C19W28_E50C23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045095">
        <property type="term" value="C:keratin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030280">
        <property type="term" value="F:structural constituent of skin epidermis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045109">
        <property type="term" value="P:intermediate filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031424">
        <property type="term" value="P:keratinization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1160:FF:000001">
        <property type="entry name" value="Keratin type II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000004">
        <property type="entry name" value="Keratin, type II cytoskeletal 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.500">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1160">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039008">
        <property type="entry name" value="IF_rod_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003054">
        <property type="entry name" value="Keratin_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45616">
        <property type="entry name" value="GATA-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45616:SF1">
        <property type="entry name" value="KERATIN, TYPE II CYTOSKELETAL 80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00038">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01276">
        <property type="entry name" value="TYPE2KERATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01391">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64593">
        <property type="entry name" value="Intermediate filament protein, coiled coil region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51842">
        <property type="entry name" value="IF_ROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0403">Intermediate filament</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF rod" evidence="5">
        <location>
            <begin position="88"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="18"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="433"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="85"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="143"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="345"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="445"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005003541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="485" mass="54541" checksum="FA43A8D9F3E73CB9" modified="2022-01-19" version="1">MTNPCKAFSSGSLCSWEASGRMSRGRTGSTSPDSLGRCSPSSVTSPSCGTLHGDGGYQSSSYLSIDGRLLAPVHLDIDTDFHAVREQEKEDIKLLNNQFVTLIEKVQCLEQQNKILTTRWNFLKDQDNSHSESDMKAIYDQYMSKMNQEMQALNYEQENLESELTEVLSTMDNFRSKYEDEIRLCSGMEYTFMELKKDLDASTLHRTELEVKLSGLQELMDLKKTIYEQELEELLTEIKDISVVMGIDNTCKLDLSRIVEEVRAQYEALALRSWEEAEALTRRKLNEGNTQSATYGGHLLDSRREIADLNIQIQKLRSCIVSQKSQCLYLEENIKETGEHGETALKDAKAKLVKLEEALQKSKEDMAHLVKEYQELMNIKLALDLEILTYRKLVEGEESSMESPIPTVISAVHSRPKHLSASTLRNSKLFARGTGSANGEMKLNGGSTKSLPSRSHSNKLAAPEADPYTYSARPKLSSLLAEECS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y7I0</accession>
    <name>A0A8C2Y7I0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein 218</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y7I0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005009191.1">
        <property type="protein sequence ID" value="ENSCJPP00005005711.1"/>
        <property type="gene ID" value="ENSCJPG00005005411.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026771">
        <property type="entry name" value="Tmem218"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31622">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31622:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034859010" description="Transmembrane protein 218" evidence="2">
        <location>
            <begin position="34"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005005711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="118" mass="12421" checksum="8D547FF9C05389A1" modified="2022-01-19" version="1">MAGAVAVGPGAVLLAGLWGAALLLCLLLARAHGIPVTRDAVVEPQQSPPAVTSPAVPFLSHTQGWGCNAVFCPQIVDTFVVGRLVLLVFMALLLVGCVLLLGMHLLEPIHARPLRCWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y7L5</accession>
    <name>A0A8C2Y7L5_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mitochondrial glutathione transporter SLC25A40</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Solute carrier family 25 member 40</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">SLC25A40</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>glutathione(in) = glutathione(out)</text>
            <dbReference type="Rhea" id="RHEA:74819"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y7L5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005010009.1">
        <property type="protein sequence ID" value="ENSCJPP00005006334.1"/>
        <property type="gene ID" value="ENSCJPG00005005950.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160249"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034634">
        <property type="term" value="F:glutathione transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048821">
        <property type="term" value="P:erythrocyte development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990542">
        <property type="term" value="P:mitochondrial transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045315">
        <property type="entry name" value="Mtm1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45760">
        <property type="entry name" value="FI19922P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45760:SF5">
        <property type="entry name" value="MITOCHONDRIAL GLUTATHIONE TRANSPORTER SLC25A40-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="13">
        <location>
            <begin position="12"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="13">
        <location>
            <begin position="138"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="13">
        <location>
            <begin position="232"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00036017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="327" mass="36610" checksum="0645F0419152375E" modified="2022-01-19" version="1">MDEMSNSDFSKTTSFQHAVSSCCGAIVTSLFVTPLDVVKTRLQAQSSPSPKGKCLVYSNGQVHHTHVCENGDGKVFYNRNRHFKGMLDAFVKIIQIEGIKSLWSGLSPTLIMALPTSVIYFTCYEKLREALRFRLGEDNDHIPIVASSLSRFVSVTAVSPVELIKTRMQYHTLSYKQLQLSIRSTVARDGWLFLWRGWSSTVLRDVPFSAVYWYNYERFKKMMCKNGGAHEPTFFIAFTAGAASGSIAAVVTLPFDVVKTHRQTEIWESETLQSKLQRDSASTWAVMRKIVAKKGIAGLFAGLFITRNVLGQAGKNALRLSESQRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y848</accession>
    <name>A0A8C2Y848_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="49">Acyl-coenzyme A thioesterase 8</fullName>
            <ecNumber evidence="5">3.1.2.1</ecNumber>
            <ecNumber evidence="48">3.1.2.11</ecNumber>
            <ecNumber evidence="14">3.1.2.2</ecNumber>
            <ecNumber evidence="47">3.1.2.27</ecNumber>
            <ecNumber evidence="46">3.1.2.3</ecNumber>
            <ecNumber evidence="45">3.1.2.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="50">Choloyl-coenzyme A thioesterase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="52">Peroxisomal acyl-coenzyme A thioester hydrolase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="51">Peroxisomal long-chain acyl-CoA thioesterase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="55" type="primary">ACOT8</name>
    </gene>
    <organism evidence="55 56">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="55" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="55" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="55" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="44">Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels. Displays no strong substrate specificity with respect to the carboxylic acid moiety of Acyl-CoAs. Hydrolyzes medium length (C2 to C20) straight-chain, saturated and unsaturated acyl-CoAS but is inactive towards substrates with longer aliphatic chains. Moreover, it catalyzes the hydrolysis of CoA esters of bile acids, such as choloyl-CoA and chenodeoxycholoyl-CoA and competes with bile acid CoA:amino acid N-acyltransferase (BAAT). Is also able to hydrolyze CoA esters of dicarboxylic acids. It is involved in the metabolic regulation of peroxisome proliferation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>(3S)-3-hydroxy-3-methylglutaryl-CoA + H2O = 3-hydroxy-3-methylglutarate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16305"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17325"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="EC" id="3.1.2.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="29">
            <dbReference type="Rhea" id="RHEA:16306"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40151"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32395"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57368"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:40152"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>(9Z)-hexadecenoyl-CoA + H2O = (9Z)-hexadecenoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40131"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32372"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:61540"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:40132"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(9Z)-octadecenoyl-CoA + H2O = (9Z)-octadecenoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40139"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:40140"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>(9Z)-tetradecenoyl-CoA + H2O = (9Z)-tetradecenoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40135"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32370"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:65060"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:40136"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="35">
            <text>(9Z,12Z)-octadecadienoyl-CoA + H2O = (9Z,12Z)-octadecadienoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40143"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30245"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57383"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="35">
            <dbReference type="Rhea" id="RHEA:40144"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="34">
            <text>2,6-dimethylheptanoyl-CoA + H2O = 2,6-dimethylheptanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:59952"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:84847"/>
            <dbReference type="ChEBI" id="CHEBI:143533"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="34">
            <dbReference type="Rhea" id="RHEA:59953"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>2-methyloctadecanoyl-CoA + H2O = 2-methyloctadecanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:59940"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:143530"/>
            <dbReference type="ChEBI" id="CHEBI:143531"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:59941"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="40">
            <text>3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + H2O = 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:59936"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:63001"/>
            <dbReference type="ChEBI" id="CHEBI:85674"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="40">
            <dbReference type="Rhea" id="RHEA:59937"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="39">
            <text>4,8-dimethylnonanoyl-CoA + H2O = 4,8-dimethylnonanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40223"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:77061"/>
            <dbReference type="ChEBI" id="CHEBI:77063"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="39">
            <dbReference type="Rhea" id="RHEA:40224"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>acetoacetyl-CoA + H2O = acetoacetate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15673"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57286"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="EC" id="3.1.2.11"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:15674"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="43">
            <text>acetyl-CoA + H2O = acetate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20289"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="3.1.2.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="43">
            <dbReference type="Rhea" id="RHEA:20290"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>butanoyl-CoA + H2O = butanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40111"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17968"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57371"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:40112"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>chenodeoxycholoyl-CoA + H2O = chenodeoxycholate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31511"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36234"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:62989"/>
            <dbReference type="EC" id="3.1.2.27"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:31512"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="33">
            <text>choloyl-CoA + H2O = cholate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14541"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29747"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57373"/>
            <dbReference type="EC" id="3.1.2.27"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="33">
            <dbReference type="Rhea" id="RHEA:14542"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>decanedioyl-CoA + H2O = decanedioate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40591"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:76283"/>
            <dbReference type="ChEBI" id="CHEBI:76316"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:40592"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>decanoyl-CoA + H2O = decanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40059"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:27689"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:61430"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:40060"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="36">
            <text>dodecanedioyl-CoA + H2O = dodecanedioate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40595"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:76273"/>
            <dbReference type="ChEBI" id="CHEBI:76315"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="36">
            <dbReference type="Rhea" id="RHEA:40596"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>dodecanoyl-CoA + H2O = dodecanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:30135"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18262"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57375"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:30136"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="37">
            <text>eicosanoyl-CoA + H2O = eicosanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40147"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32360"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57380"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="37">
            <dbReference type="Rhea" id="RHEA:40148"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="32">
            <text>glutaryl-CoA + H2O = glutarate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40575"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30921"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57378"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="32">
            <dbReference type="Rhea" id="RHEA:40576"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>hexadecanoyl-CoA + H2O = hexadecanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16645"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="EC" id="3.1.2.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:16646"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>hexanedioyl-CoA + H2O = hexanedioate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40583"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17128"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:76327"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:40584"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>hexanoyl-CoA + H2O = hexanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40115"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17120"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:62620"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:40116"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="38">
            <text>malonyl-CoA + H2O = malonate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40219"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15792"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="38">
            <dbReference type="Rhea" id="RHEA:40220"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>octadecanoyl-CoA + H2O = octadecanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:30139"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57394"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="31">
            <dbReference type="Rhea" id="RHEA:30140"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>octanedioyl-CoA + H2O = octanedioate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40587"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:76282"/>
            <dbReference type="ChEBI" id="CHEBI:76317"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:40588"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>octanoyl-CoA + H2O = octanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:30143"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25646"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57386"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:30144"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="41">
            <text>propanoyl-CoA + H2O = propanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40103"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17272"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="41">
            <dbReference type="Rhea" id="RHEA:40104"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>prostaglandin F2alpha-CoA + H2O = prostaglandin F2alpha + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:59948"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57404"/>
            <dbReference type="ChEBI" id="CHEBI:143532"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="30">
            <dbReference type="Rhea" id="RHEA:59949"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="42">
            <text>succinyl-CoA + H2O = succinate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11516"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="EC" id="3.1.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="42">
            <dbReference type="Rhea" id="RHEA:11517"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>tetradecanoyl-CoA + H2O = tetradecanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40119"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30807"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:40120"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the C/M/P thioester hydrolase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.1" evidence="5"/>
    <dbReference type="EC" id="3.1.2.11" evidence="48"/>
    <dbReference type="EC" id="3.1.2.2" evidence="14"/>
    <dbReference type="EC" id="3.1.2.27" evidence="47"/>
    <dbReference type="EC" id="3.1.2.3" evidence="46"/>
    <dbReference type="EC" id="3.1.2.5" evidence="45"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y848"/>
    <dbReference type="Ensembl" id="ENSCJPT00005010962.1">
        <property type="protein sequence ID" value="ENSCJPP00005007055.1"/>
        <property type="gene ID" value="ENSCJPG00005006509.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000004207"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047603">
        <property type="term" value="F:acetoacetyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003986">
        <property type="term" value="F:acetyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033882">
        <property type="term" value="F:choloyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047994">
        <property type="term" value="F:hydroxymethylglutaryl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052816">
        <property type="term" value="F:long-chain fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052815">
        <property type="term" value="F:medium-chain fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004778">
        <property type="term" value="F:succinyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036109">
        <property type="term" value="P:alpha-linolenic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043649">
        <property type="term" value="P:dicarboxylic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901570">
        <property type="term" value="P:fatty acid derivative biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042759">
        <property type="term" value="P:long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010561">
        <property type="term" value="P:negative regulation of glycoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006636">
        <property type="term" value="P:unsaturated fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd03444">
        <property type="entry name" value="Thioesterase_II_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03445">
        <property type="entry name" value="Thioesterase_II_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.210:FF:000002">
        <property type="entry name" value="acyl-coenzyme A thioesterase 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="entry name" value="Acyl-CoA thioesterase, double hotdog domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003703">
        <property type="entry name" value="Acyl_CoA_thio"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049449">
        <property type="entry name" value="TesB_ACOT8-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025652">
        <property type="entry name" value="TesB_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00189">
        <property type="entry name" value="tesB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066">
        <property type="entry name" value="ACYL-COA THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066:SF34">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13622">
        <property type="entry name" value="4HBT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02551">
        <property type="entry name" value="Acyl_CoA_thio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="56" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Acyl-CoA thioesterase-like N-terminal HotDog" evidence="54">
        <location>
            <begin position="54"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA thioesterase 2 C-terminal" evidence="53">
        <location>
            <begin position="211"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00035852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00050199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00050280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00050352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00050576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00050783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00051113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00051162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00051199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00051261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00051360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00051390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00051478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00051487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="ARBA" id="ARBA00051522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="ARBA" id="ARBA00051584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="35">
        <source>
            <dbReference type="ARBA" id="ARBA00051757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="36">
        <source>
            <dbReference type="ARBA" id="ARBA00052008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="37">
        <source>
            <dbReference type="ARBA" id="ARBA00052034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="38">
        <source>
            <dbReference type="ARBA" id="ARBA00052089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="39">
        <source>
            <dbReference type="ARBA" id="ARBA00052112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="40">
        <source>
            <dbReference type="ARBA" id="ARBA00052155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="41">
        <source>
            <dbReference type="ARBA" id="ARBA00052772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="42">
        <source>
            <dbReference type="ARBA" id="ARBA00052821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="43">
        <source>
            <dbReference type="ARBA" id="ARBA00052880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="44">
        <source>
            <dbReference type="ARBA" id="ARBA00057463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="45">
        <source>
            <dbReference type="ARBA" id="ARBA00066312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="46">
        <source>
            <dbReference type="ARBA" id="ARBA00066314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="47">
        <source>
            <dbReference type="ARBA" id="ARBA00066445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="48">
        <source>
            <dbReference type="ARBA" id="ARBA00066473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="49">
        <source>
            <dbReference type="ARBA" id="ARBA00068564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="50">
        <source>
            <dbReference type="ARBA" id="ARBA00081170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="51">
        <source>
            <dbReference type="ARBA" id="ARBA00081380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="52">
        <source>
            <dbReference type="ARBA" id="ARBA00081859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="53">
        <source>
            <dbReference type="Pfam" id="PF02551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="54">
        <source>
            <dbReference type="Pfam" id="PF13622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="55">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005007055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="56">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="325" mass="36379" checksum="327B00C3610C1881" modified="2022-01-19" version="1">MAAPGDGGGAGSGSGSGSGLQRLAAAGDLRSVLLTSVLNLERLELDLFRGQHHWVPATRRLFGGQIVGQALVAAARAVSRELQAHSLHCYFVRAGDPKVPVLYEVERTRTGKSFSVRSVKAIQHGKPIFICQASFQLAQQSPVQHQFTMPNVPPPEELLTQEELIEKFLQNPNLAERYRKHLNKIQAEDVPIDIKPVNPPDIFCTEPQEPKQFFWVRARGYIGETDMKVHCCVAAYISDYAFLGTALLPHRQYNVKFMVSLDHSMWFHAPFRSDHWMLYECESPWAGGCRGLVHGRLWRRDGVLAVTCTQEGVIRVEENPNQSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y8C9</accession>
    <name>A0A8C2Y8C9_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Rap1 GTPase-GDP dissociation stimulator 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">RAP1GDS1</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015717592.1">
        <property type="nucleotide sequence ID" value="XM_015862106.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y8C9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005011662.1">
        <property type="protein sequence ID" value="ENSCJPP00005007535.1"/>
        <property type="gene ID" value="ENSCJPG00005006934.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107313661"/>
    <dbReference type="CTD" id="5910"/>
    <dbReference type="GeneTree" id="ENSGT00390000014293"/>
    <dbReference type="OrthoDB" id="26149at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0086098">
        <property type="term" value="P:angiotensin-activated signaling pathway involved in heart process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080120">
        <property type="term" value="P:CAAX-box protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003300">
        <property type="term" value="P:cardiac muscle hypertrophy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032471">
        <property type="term" value="P:negative regulation of endoplasmic reticulum calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051561">
        <property type="term" value="P:positive regulation of mitochondrial calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034504">
        <property type="term" value="P:protein localization to nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070376">
        <property type="term" value="P:regulation of ERK5 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904464">
        <property type="term" value="P:regulation of matrix metallopeptidase secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010821">
        <property type="term" value="P:regulation of mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000127">
        <property type="entry name" value="rap1 GTPase-GDP dissociation stimulator 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000141">
        <property type="entry name" value="rap1 GTPase-GDP dissociation stimulator 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000144">
        <property type="entry name" value="rap1 GTPase-GDP dissociation stimulator 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040144">
        <property type="entry name" value="RAP1GDS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10957">
        <property type="entry name" value="RAP1 GTPASE-GDP DISSOCIATION STIMULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ARM" evidence="8">
        <location>
            <begin position="89"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="8">
        <location>
            <begin position="357"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005007535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="607" mass="66340" checksum="5AA2BF2724F4A05C" modified="2022-01-19" version="1">MDNLSDALKKLKITATDSTADSLEGCLDCLLQALAQNNMETSEKIQKSGVLQVFASLLMPQSSCTAKVANIIAEVARNEFMRNPCVDAGLIPPLVQMLNCKDQEVLLQTGRALGNICYDSHEGRNAVDHAGGAHIVVDLIRSLCSKTDPASEKLLTVFCGMLMNYSNENDTLQSQLINMGVIPTLVKLLGIHCQNAALTEMCLVAFGNLAELESSKEQFAYTNIAEELVKLFKKQVEHDKKEMIFEVLAPLAENDVIKLQLVEAGLVECLLEVVQKTVDSDKEDDVAELKTASDLMVLLLLGDESMQKLFEGGRGSVFQRVLSWIPSNSHQLQLAGALAIANFARNDGNCIHMVDNGIVQKLMDLLDRHVEDGNVTVQHAALSALRNLAIPVVNKAKMLSAGVAEAVLKFLRSEMPPVQFKLLGTLRMLIDAQAEAAEQLGKNAKLVERLVEWCEAKDHAGVMGESNRLLSALIRHSKSKDVIRTIVQSGGIKHLVTMATSEHVIMQNEALVALALIAALELVTAEKDLENAQLVQILHRLLSDDRSAPEIKYNSMVLVCALIGSESLQKEVQNMAFLEVVSKLRSHENKTVAQQASLTEQRLAVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y9H4</accession>
    <name>A0A8C2Y9H4_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cyclin-G2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">CCNG2</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">May play a role in growth regulation and in negative regulation of cell cycle progression.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclin family. Cyclin G subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y9H4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005015276.1">
        <property type="protein sequence ID" value="ENSCJPP00005010284.1"/>
        <property type="gene ID" value="ENSCJPG00005008990.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156423"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd20584">
        <property type="entry name" value="CYCLIN_CCNG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000056">
        <property type="entry name" value="Cyclin G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000006">
        <property type="entry name" value="Cyclin I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="6 10" id="KW-0195">Cyclin</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="11">
        <location>
            <begin position="52"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00058130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00073878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005010284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="349" mass="40185" checksum="7CA30070B4415960" modified="2022-01-19" version="1">MGSEALRLFRQLNLHLELEGRYQPRERGISLIECAAENENTLCPRQRNAKVEDLWSLTNFFGFATETFVLAVNILDRFLALMKVKPKHLSCIGVCCFQLAARVVEEECNIPSAHEIIRISQCKCTVSDLKRMEKIISEKLHFEFKATTALTFLHLYHTIVLCHTSERKEVLNLDKLEAQLKACNCRLVFSKAKPSVLALCLLTLEVQSLKSVELFEILLRVQKHSKISDCDLLYWRELVSKCLADYSSPECCKPDHKKLVWIVSRRTAQNLQNSYYSVPELPTIPEGGCFKESERWKCSTSNWQLCEPRWSQSPLIARRPATILLTEWVLGTELQQHREVRILGSFVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YAP5</accession>
    <name>A0A8C2YAP5_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">PurE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">PAICS</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (carboxylase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the AIR carboxylase family. Class II subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the SAICAR synthetase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_032300127.1">
        <property type="nucleotide sequence ID" value="XM_032444236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YAP5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005018040.1">
        <property type="protein sequence ID" value="ENSCJPP00005012458.1"/>
        <property type="gene ID" value="ENSCJPG00005010590.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107313717"/>
    <dbReference type="KEGG" id="cjo:107313717"/>
    <dbReference type="CTD" id="10606"/>
    <dbReference type="GeneTree" id="ENSGT00390000010172"/>
    <dbReference type="OrthoDB" id="9991235at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004638">
        <property type="term" value="F:phosphoribosylaminoimidazole carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004639">
        <property type="term" value="F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097294">
        <property type="term" value="P:'de novo' XMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006177">
        <property type="term" value="P:GMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01416">
        <property type="entry name" value="SAICAR_synt_Ade5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000183">
        <property type="entry name" value="Probable multifunctional protein ADE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000020">
        <property type="entry name" value="Probable multifunctional protein ADE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1970:FF:000006">
        <property type="entry name" value="Probable multifunctional protein ADE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02045">
        <property type="entry name" value="PurE_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00137">
        <property type="entry name" value="SAICAR_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033626">
        <property type="entry name" value="PurE_classII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000031">
        <property type="entry name" value="PurE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028923">
        <property type="entry name" value="SAICAR_synt/ADE2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050089">
        <property type="entry name" value="SAICAR_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018236">
        <property type="entry name" value="SAICAR_synthetase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01162">
        <property type="entry name" value="purE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43599:SF11">
        <property type="entry name" value="BIFUNCTIONAL PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE_PHOSPHORIBOSYLAMINOIMIDAZOLE SUCCINOCARBOXAMIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43599">
        <property type="entry name" value="MULTIFUNCTIONAL PROTEIN ADE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00731">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01259">
        <property type="entry name" value="SAICAR_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01001">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52255">
        <property type="entry name" value="N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01057">
        <property type="entry name" value="SAICAR_SYNTHETASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01058">
        <property type="entry name" value="SAICAR_SYNTHETASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PurE" evidence="13">
        <location>
            <begin position="267"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005012458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="426" mass="47224" checksum="B4A990AEB2B337EC" modified="2022-01-19" version="1">MAPAASELKLGKKVNEGKTKEVYELPDIPGCVLMQSKDQITAGNAARKDRMEGKAAISNTTTSCVFQLLQEAGIKTAFVRKQSDTAFIAAHCEMIPIEWVCRRIATGSFLKRNPGVKEGYKFYPPKIEMFYKDDANNDPQWSEEQLIEAKFSFAGLTIGKTEVDIMARSTQAIFEILEKSWQPQNCTLVDLKIEFGVNILTKEIVLADVIDNDSWRLWPSGDRSQQKDKQSYRDLKEVTPEALQMVKRNFEWVAERVELLLKTKSQGRVVVLMGSTSDLGHCEKIKKACATFGIPCELRVTSAHKGPDETLRIKAEYEGDGIPTVFVAVAGRSNGLGPVMSGNTAYPVVNCPPLSSDWGAQDVWSSLRLPSGLGCPTTLSPEGAAQFAAQIFGLNNHLVWAKLRANMLNTWISLKQADKKLRECTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YCG1</accession>
    <name>A0A8C2YCG1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">TGF-beta-activated kinase 1 and MAP3K7-binding protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Mitogen-activated protein kinase kinase kinase 7-interacting protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">TGF-beta-activated kinase 1-binding protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">TAB1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Key adapter protein that plays an essential role in JNK and NF-kappa-B activation and proinflammatory cytokines production in response to stimulation with TLRs and cytokines. Mechanistically, associates with the catalytic domain of MAP3K7/TAK1 to trigger MAP3K7/TAK1 autophosphorylation leading to its full activation. Similarly, associates with MAPK14 and triggers its autophosphorylation and subsequent activation. In turn, MAPK14 phosphorylates TAB1 and inhibits MAP3K7/TAK1 activation in a feedback control mechanism. Also plays a role in recruiting MAPK14 to the TAK1 complex for the phosphorylation of the TAB2 and TAB3 regulatory subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with XIAP and BIRC7. Interacts with TRAF6 and MAP3K7; during IL-1 signaling. Identified in the TRIKA2 complex composed of MAP3K7, TAB1 and TAB2. Interacts with TRAF6 and MAPK14; these interactions allow MAPK14 autophosphorylation. Interacts with STING1; interaction takes place following cGAMP activation and promotes TAB1 recruitment to the endoplasmic reticulum, triggering MAP3K7/TAK1 activation and STING1 phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015715820.1">
        <property type="nucleotide sequence ID" value="XM_015860334.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YCG1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005022797.1">
        <property type="protein sequence ID" value="ENSCJPP00005016186.1"/>
        <property type="gene ID" value="ENSCJPG00005013320.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107312690"/>
    <dbReference type="KEGG" id="cjo:107312690"/>
    <dbReference type="CTD" id="10454"/>
    <dbReference type="GeneTree" id="ENSGT00510000048276"/>
    <dbReference type="OrthoDB" id="10049211at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035904">
        <property type="term" value="P:aorta development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007249">
        <property type="term" value="P:canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003279">
        <property type="term" value="P:cardiac septum development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140896">
        <property type="term" value="P:cGAS/STING signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060976">
        <property type="term" value="P:coronary vasculature development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003007">
        <property type="term" value="P:heart morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030324">
        <property type="term" value="P:lung development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038061">
        <property type="term" value="P:non-canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141111">
        <property type="term" value="P:positive regulation of cGAS/STING signaling pathway"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032481">
        <property type="term" value="P:positive regulation of type I interferon production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032527">
        <property type="term" value="P:protein exit from endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007179">
        <property type="term" value="P:transforming growth factor beta receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000014">
        <property type="entry name" value="TGF-beta-activated kinase 1 and MAP3K7-binding protein 1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF533">
        <property type="entry name" value="TGF-BETA-ACTIVATED KINASE 1 AND MAP3K7-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="15">
        <location>
            <begin position="28"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="414"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="414"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00057862"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00062935"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00074232"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00080486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00080658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005016186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="502" mass="54802" checksum="8DC482440C3D2CA8" modified="2022-01-19" version="1">MAAQRRSLLQSEQQPSWTDDLPSCHLSGVGSAPNRSYSADGKGTEGHPLEDNWLKFRSENNCYLYGVFNGYDGNRVTNFVGQRLSAELLLGQLHADHSDADVRRVLLQAFDVVERSFLESIDDALAEKASLQSQLPEGVPHHQLPPQYQKIVERLKVVEQEISGGAMAIVAVVLNNKLYIANVGTNRALLCKSTVDGLQVTQLNVDHTTENEDELFRFSQLGLDAGKIKQVGTIRGQESTRRIGDYKVKYGYTDIELLSAAKSKPIIAEPEIHGGHSLDGVTGFLVLMSEGLYKALEAAHGPGQANQEIAAMIATEFAKQTSLDAVAQAVVDRVKRIHCDTFASGGERSKFCPRHEDMTLLVRNFGYPLGEMSQPTLTPTQGGRVYPVSVPYSSSQSTSKMSVTLSLVMPSQGQMVNGAHSSSTLDEATPTLTNQSPTVTLQSTNTHTQSSSSSSDGGLFRSRPTHSLQPDEDGRVEPYVDFAEFYRLWNMDHGEQGALTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YDZ9</accession>
    <name>A0A8C2YDZ9_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mal, T cell differentiation protein like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MALL</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2YDZ9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005027123.1">
        <property type="protein sequence ID" value="ENSCJPP00005019606.1"/>
        <property type="gene ID" value="ENSCJPG00005015879.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161444"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019911">
        <property type="term" value="F:structural constituent of myelin sheath"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042552">
        <property type="term" value="P:myelination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013295">
        <property type="entry name" value="MAL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050578">
        <property type="entry name" value="MARVEL-CKLF_proteins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22776:SF24">
        <property type="entry name" value="MAL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22776">
        <property type="entry name" value="MARVEL-CONTAINING POTENTIAL LIPID RAFT-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01884">
        <property type="entry name" value="MALPROTEIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51225">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="7">
        <location>
            <begin position="23"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005019606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="155" mass="17086" checksum="CC3C0DD1B91BEB4E" modified="2022-01-19" version="1">GAMASASPTAATSQPSLPSGPVIFKTIPYAFILPEIICGAWVWILVAATSVSFPLLQGWVMYVSLTSCLISLLLLISYLFGFHRNSNNWKVLDSLYHGATAILYMSAAVLQANATINSEFHFSSPLYYQLNCAASFFAFITTFLYILHAFSNYYQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1986-07-21" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>P67886</accession>
    <accession>P01018</accession>
    <name>ANGT_COTJA</name>
    <protein>
        <recommendedName>
            <fullName>Angiotensinogen</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Serpin A8</fullName>
        </alternativeName>
        <component>
            <recommendedName>
                <fullName>Angiotensin-1</fullName>
            </recommendedName>
            <alternativeName>
                <fullName>Angiotensin I</fullName>
                <shortName>Ang I</shortName>
            </alternativeName>
        </component>
        <component>
            <recommendedName>
                <fullName>Angiotensin-2</fullName>
            </recommendedName>
            <alternativeName>
                <fullName>Angiotensin II</fullName>
                <shortName>Ang II</shortName>
            </alternativeName>
        </component>
        <component>
            <recommendedName>
                <fullName>Angiotensin-3</fullName>
            </recommendedName>
            <alternativeName>
                <fullName>Angiotensin III</fullName>
                <shortName>Ang III</shortName>
            </alternativeName>
            <alternativeName>
                <fullName>Des-Asp[1]-angiotensin II</fullName>
            </alternativeName>
        </component>
    </protein>
    <gene>
        <name type="primary">AGT</name>
        <name type="synonym">SERPINA8</name>
    </gene>
    <organism>
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1990" name="Gen. Comp. Endocrinol." volume="79" first="12" last="22">
            <title>Vasopressor and depressor effects of native angiotensins and inhibition of these effects in the Japanese quail.</title>
            <authorList>
                <person name="Takei Y."/>
                <person name="Hasegawa Y."/>
            </authorList>
            <dbReference type="PubMed" id="2191893"/>
            <dbReference type="DOI" id="10.1016/0016-6480(90)90083-X"/>
        </citation>
        <scope>PROTEIN SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">In response to lowered blood pressure, the enzyme renin cleaves angiotensin-1, from angiotensinogen. ACE (angiotensin converting enzyme) then removes a dipeptide to yield the physiologically active peptide angiotensin-2, the most potent pressor substance known, which helps regulate volume and mineral balance of body fluids.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the serpin family.</text>
    </comment>
    <dbReference type="PIR" id="A60624">
        <property type="entry name" value="A60624"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042310">
        <property type="term" value="P:vasoconstriction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0903">Direct protein sequencing</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0838">Vasoactive</keyword>
    <keyword id="KW-0839">Vasoconstrictor</keyword>
    <feature type="peptide" id="PRO_0000032479" description="Angiotensin-1" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="peptide" id="PRO_0000032480" description="Angiotensin-2" evidence="1">
        <location>
            <begin position="1"/>
            <end position="8"/>
        </location>
    </feature>
    <feature type="peptide" id="PRO_0000032481" description="Angiotensin-3" evidence="1">
        <location>
            <begin position="2"/>
            <end position="8"/>
        </location>
    </feature>
    <feature type="non-terminal residue">
        <location>
            <position position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P01019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="2191893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <evidence type="ECO:0000305" key="4">
        <source>
            <dbReference type="PubMed" id="2191893"/>
        </source>
    </evidence>
    <sequence length="10" mass="1232" checksum="CEFBEDD761F2DB42" modified="1986-07-21" version="1" fragment="single">DRVYVHPFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SL78</accession>
    <name>A0A8C2SL78_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Histone deacetylase 1</fullName>
            <shortName evidence="14">HD1</shortName>
            <ecNumber evidence="14">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">HDAC1</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also functions as deacetylase for non-histone proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N(6)-(2E)-butenoyl-L-lysyl-[protein] + H2O = (2E)-2-butenoate + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:69172"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:13707"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:35899"/>
            <dbReference type="ChEBI" id="CHEBI:137954"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:69173"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:58197"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(6)-acetyl-L-lysyl-[protein] + H2O = L-lysyl-[protein] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58108"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:58109"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13 14">Belongs to the histone deacetylase family. HD Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="14"/>
    <dbReference type="RefSeq" id="XP_015738807.2">
        <property type="nucleotide sequence ID" value="XM_015883321.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SL78"/>
    <dbReference type="Ensembl" id="ENSCJPT00005000922.1">
        <property type="protein sequence ID" value="ENSCJPP00005000499.1"/>
        <property type="gene ID" value="ENSCJPG00005000595.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107323875"/>
    <dbReference type="KEGG" id="cjo:107323875"/>
    <dbReference type="CTD" id="3065"/>
    <dbReference type="GeneTree" id="ENSGT00940000154301"/>
    <dbReference type="OrthoDB" id="1918432at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000792">
        <property type="term" value="C:heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016581">
        <property type="term" value="C:NuRD complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070822">
        <property type="term" value="C:Sin3-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017053">
        <property type="term" value="C:transcription repressor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070888">
        <property type="term" value="F:E-box binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042826">
        <property type="term" value="F:histone deacetylase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160009">
        <property type="term" value="F:histone decrotonylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035851">
        <property type="term" value="F:Krueppel-associated box domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051059">
        <property type="term" value="F:NF-kappaB binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002039">
        <property type="term" value="F:p53 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990841">
        <property type="term" value="F:promoter-specific chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160216">
        <property type="term" value="F:protein lysine delactylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000979">
        <property type="term" value="F:RNA polymerase II core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001222">
        <property type="term" value="F:transcription corepressor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032922">
        <property type="term" value="P:circadian regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006346">
        <property type="term" value="P:DNA methylation-dependent constitutive heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042733">
        <property type="term" value="P:embryonic digit morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007492">
        <property type="term" value="P:endoderm development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009913">
        <property type="term" value="P:epidermal cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061029">
        <property type="term" value="P:eyelid development in camera-type eye"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061198">
        <property type="term" value="P:fungiform papilla formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043922">
        <property type="term" value="P:host-mediated suppression of viral transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060766">
        <property type="term" value="P:negative regulation of androgen receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043124">
        <property type="term" value="P:negative regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001243">
        <property type="term" value="P:negative regulation of intrinsic apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048709">
        <property type="term" value="P:oligodendrocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033148">
        <property type="term" value="P:positive regulation of intracellular estrogen receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048714">
        <property type="term" value="P:positive regulation of oligodendrocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000003">
        <property type="entry name" value="Histone deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF49">
        <property type="entry name" value="HISTONE DEACETYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037913">
        <property type="entry name" value="His_deacetylse_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="19" id="KW-0732">Signal</keyword>
    <keyword evidence="8 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 14" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034744445" description="Histone deacetylase 1" evidence="19">
        <location>
            <begin position="18"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Histone deacetylase" evidence="20">
        <location>
            <begin position="33"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="381"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="393"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="406"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="422"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="460"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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            <name>a divalent metal cation</name>
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        <location>
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        <ligand>
            <name>substrate</name>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
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        <source>
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    <sequence length="485" mass="55579" checksum="251C386554A29BE7" modified="2022-01-19" version="1">MWLYLKQFVFFPAVTKSFLFPGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSAGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVISKVMETFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQPIPEDAVQEDSGDEEEEDPEKRISIRNSDKRISCDEEFSDSEDEGEGGRKNVANFKKAKRVKTEEEKEEEEKKDEKEEEKAKEEKAEPKGVKEEAKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SMZ0</accession>
    <name>A0A8C2SMZ0_COTJA</name>
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        <recommendedName>
            <fullName evidence="3">Transmembrane protein 192</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">TMEM192</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
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            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
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            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
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            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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        <text evidence="2">Belongs to the TMEM192 family.</text>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="269" mass="30675" checksum="11226153940DC01F" modified="2022-01-19" version="1">MAVTARQQDLDNGSLEITQSLEDEALLDAPLISSRTLYSQLRPRFHAIPVVLLANFLLLLHVAFVVLAFLAAMFCSYPNPNQDKCPGNYTHPFKVQTVIIIAKVILWILHVFFERYVHHHHSKIRSRGYFLIYRSTRHLKRLPLVMHSTGNAALLLILSTQHSFPDHSKVYLYLILGVLGLELISSLTCLVIYTVKISNFNRAKPRPDIIEEEKLYAYSSHITSEVGFGENSSLEEIVEKQGDVIEYLQRHNALLSKRLLALTSQQIKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SNN9</accession>
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        <submittedName>
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    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
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        <lineage>
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            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
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            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
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            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
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    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
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                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    </dbReference>
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        <property type="gene ID" value="ENSCJPG00005001453.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005002404.1">
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        <property type="gene ID" value="ENSCJPG00005001453.1"/>
    </dbReference>
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    <dbReference type="GeneTree" id="ENSGT00940000157028"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Znf_MYM"/>
    </dbReference>
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        <property type="entry name" value="ZnF_MYMT-QRICH1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45736">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45736:SF6">
        <property type="entry name" value="ZINC FINGER MYM-TYPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12012">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="9"/>
    </dbReference>
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        <property type="match status" value="9"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
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            <end position="280"/>
        </location>
    </feature>
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        </location>
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        </location>
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        </location>
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        </location>
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        </location>
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        </location>
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        <location>
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            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="715"/>
            <end position="734"/>
        </location>
    </feature>
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        <location>
            <begin position="910"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="196"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="922"/>
            <end position="932"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005001450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1260" mass="142494" checksum="38553865EA08FA3A" modified="2022-01-19" version="1">MDTSSLGGLELSEHTPDLANTTMAAGLANVGNTFASPPSSIVSRPGKFQNSTVDDDDDVVFIEPVQTPQNSTSLIAEQRNAAFALSKNDELQGDDCKMLPPPKDLNSQKGSISETIIIDDEEDIETNQGQEKNASSFNERRLPECKNRANDMDFSASSFSRSKTKTGVGPFNPGRMNVAGDVFQNGESVTHHNPDSWISQSASFPRNQKQPGVDSLSPVASLPKQIFQPSTQQPPPSKQVKVTCANCKKPLQKGQTAYQRKGSAHLFCSTTCLSSFSHKPAPKKLCVMCRKDITTMKGTIVAQVDSSESFQEFCSTSCLSFYEDKQNPSKGALNKSRCTICGKLTEIRHEVSFKNMTHKLCSDHCFNRYRMANGLIMNCCEHCGEYLPSKGAGNNTLTIDGQQKRFCCQNCVGEYKQKYGKLTSCTGCRAQCRFFDMTQCIGPNGYLEPYCSTACMNTHKSKHAESQSMEIICHFCKRNSLPQYQASMPDGKLYNFCSSSCVAKFQALSDQSSTNGQFVSPGDIQLKCNYCKSSFCSKPEVLEWENKVYQFCSRACSDDYKKLHCIVTYCEYCQEEKTLHETVNFSGIKRPFCSEGCKLLYKQDFARRLGLRCVTCNYCSQLCKKGATKELDGVVRDFCSEECCKKFQDWYYKAARCDCCKSQGTLREKVQWRGEMKHFCDQHCLLRFYCQQNEPNLATQKGPENLQYDQGCQTPRTKVTGSAPPPSPTPNREMKNKAVLCKPLTMTKATYCKPHMQTKSCQTEDDWKKEYVPVPIPVPIYVPVPMNMYSQTVPVPTSIPVPVPVPIFLPTTLDSTEKIFAAIEDLRGKVPSNPLETELLTLSGMVPEHEGKAEVSDAACVIAESNLLNSETEAQTSLPDVLYEPDLDIEIDFPRATEELDTENEFLLPPVFGEEYEEQPRPRPKKKGVKRRAVSEYQSHDDSSENSECSFPFKYTYGVNAWKHWVKSQHLDKELPESEELKSTKSVKLKEDLLSHTAAELNYGLAHFVNEIRRPNGENYAPDSIYYLCLGIQEYLYGSNRKDNIFIDPTYQTFEQELNKILRSWQPSILPDGSIFSRVEEDYLWRIKQLGSHSPVALLNTLFYFNTKYFGLKTVEQHLRLSFGTVFRQWKKNPLTMESKACLRYQVSSLCRADSEDKITTGKRKHEDDEPVFEQIENTSDPTRCPVKLFECYLSKSPQNLNQRTDVFYLQPECSVSSDSSVWYTSTSLDRNTLENMLVRVLLVKDIYEKDNYELDEDID</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SNS9</accession>
    <name>A0A8C2SNS9_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="27">Vesicular glutamate transporter 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="28">Solute carrier family 17 member 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="32" type="primary">LOC107307478</name>
    </gene>
    <organism evidence="32 33">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="32" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="32" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>3 Na(+)(out) + phosphate(out) = 3 Na(+)(in) + phosphate(in)</text>
            <dbReference type="Rhea" id="RHEA:71255"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>K(+)(in) + H(+)(out) = K(+)(out) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:29467"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>L-glutamate(out) = L-glutamate(in)</text>
            <dbReference type="Rhea" id="RHEA:66336"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>chloride(in) = chloride(out)</text>
            <dbReference type="Rhea" id="RHEA:29823"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>phosphate(in) = phosphate(out)</text>
            <dbReference type="Rhea" id="RHEA:32823"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Secretory vesicle</location>
            <location evidence="1">Synaptic vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="22">Synapse</location>
            <location evidence="22">Synaptosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="26">Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. VGLUT subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SNS9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005002474.1">
        <property type="protein sequence ID" value="ENSCJPP00005001498.1"/>
        <property type="gene ID" value="ENSCJPG00005000657.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159110"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060076">
        <property type="term" value="C:excitatory synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005326">
        <property type="term" value="F:neurotransmitter transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098700">
        <property type="term" value="P:neurotransmitter loading into synaptic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050803">
        <property type="term" value="P:regulation of synapse structure or activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035249">
        <property type="term" value="P:synaptic transmission, glutamatergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000226">
        <property type="entry name" value="Vesicular GLUtamate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF29">
        <property type="entry name" value="VESICULAR GLUTAMATE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="18" id="KW-0868">Chloride</keyword>
    <keyword evidence="16" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="20" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="19" id="KW-0407">Ion channel</keyword>
    <keyword evidence="14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="15 30" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0532">Neurotransmitter transport</keyword>
    <keyword evidence="6" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="33" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0915">Sodium</keyword>
    <keyword evidence="17" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="10" id="KW-0769">Symport</keyword>
    <keyword evidence="12" id="KW-0770">Synapse</keyword>
    <keyword evidence="7" id="KW-0771">Synaptosome</keyword>
    <keyword evidence="8 30" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 30" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="30">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="30">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="30">
        <location>
            <begin position="184"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="30">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="30">
        <location>
            <begin position="280"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="30">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="30">
        <location>
            <begin position="355"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="31">
        <location>
            <begin position="53"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00024167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00034102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00035839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00036616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00036683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00038044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00039390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00041351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00047912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="31">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005001498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="499" mass="53693" checksum="D4329DBF8E83333F" modified="2022-01-19" version="1">MVCPPPRLLERRQDDAEVLELSCGVTGGVSSPTSPPRPPIVDCHCFGLPRRYGIAVLCAVGFCISFGIRCNLGVAVVSMVNGEHAQFHWDPETVGMIHGSFFWGYIITQIPGGFIAQKFAANRVFGLAIVSTSVLNMLIPSAARTHVGCVIAVRVMQGLVEGVTYPACHGIWSKWAPPLERSRLATTAFCGSYAGAVIAMPLAGILVQYTGWSSVFYVYGSFGLCWYMFWVLVSYESPAVHPTISSEERKYIQDSIGESQGSNPLLLATPWRQFLTSLPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGLLSALPHLVMTIVVPIGGQIADHLRSRGIMSTTNVRKMMNCGGFYGVLLSMGSLLWGLGSLWVSMGSLMGGGLYGGLYGVSMGPRGPMGLSMGSLWGLYGSSIGPYGGLTLLDLKPNTLLEVGGPSIWGGGLYGALYGVPIYGLGSHLADSQTQTLLKVGRLADEQQSRRSNCGKKLATMMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SP31</accession>
    <name>A0A8C2SP31_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Kelch like family member 30</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">KLHL30</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SP31"/>
    <dbReference type="Ensembl" id="ENSCJPT00005002786.1">
        <property type="protein sequence ID" value="ENSCJPP00005001648.1"/>
        <property type="gene ID" value="ENSCJPG00005001693.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158597"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="CDD" id="cd18469">
        <property type="entry name" value="BACK_KLHL30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.420:FF:000001">
        <property type="entry name" value="Kelch-like family member 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017096">
        <property type="entry name" value="BTB-kelch_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030582">
        <property type="entry name" value="KLHL30_BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412">
        <property type="entry name" value="KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412:SF398">
        <property type="entry name" value="KELCH-LIKE PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037037">
        <property type="entry name" value="Kelch-like_protein_gigaxonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="33"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005001648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="591" mass="65844" checksum="F0329FF1CBB38919" modified="2022-01-19" version="1">MVRNVDDFDFCLPSHAQGVLEGLQRLRAHPKLSDVTLLAGGREFPCHRGVLALCSHYFHAMFSGDFAESIAARVELKEVDPAALEMLLDFAYTGKVTVNQSNVEGLMRTSSQLHFPTIQQVCSRYLRQQMDATNCLGICEFGESHGCPEVSSKAWSFLQENFEAVSQQEEFLQLSKERLAVYLSNEQLQVQEEQSVAEAVLRWVRYDPGQRAQFLPELLELARLVSLPDHYLQNLLATEPLVRDSAASQALVARSRAALGATGTVPAPPKAAPPQKLEEVLVVVGGRVLEESEDEEGGLETPAAPRNFAFYNPKTRRWMALPDFPDYNKWGFSLVALNNDVYVTGGSRGSRNDTWSTTQAWRFCPKDGVWTAIASMLRARTNHTSAVLNGEIYVLGGTTVEVVEVERYDPYNQSWAAISPALKYVSNFAAAGCLGKLYLVGSCAVKYNALTLQCYNPVRGERPSNPRGSPSGYLSAPRCATLHGLIYLIGDNTKKVHVYDPEANIWQKVQLLHTLHENGGMVPLGDRLFVTGGHWKGMDGDYRVEMEVYDCAKDRWVREGSLPCLWLFHSSSSIFMDTSKWTEAFPGDQEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SPI2</accession>
    <name>A0A8C2SPI2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NELL2-interacting cell ontogeny regulator 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">NICOL1</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NICOL family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SPI2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005001357.1">
        <property type="protein sequence ID" value="ENSCJPP00005000779.1"/>
        <property type="gene ID" value="ENSCJPG00005000845.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000013043"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028147">
        <property type="entry name" value="NICOL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35451">
        <property type="entry name" value="NEUROPEPTIDE-LIKE PROTEIN C4ORF48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35451:SF1">
        <property type="entry name" value="NEUROPEPTIDE-LIKE PROTEIN C4ORF48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15161">
        <property type="entry name" value="Neuropep_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00046322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005000779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="138" mass="15100" checksum="8E77EFF5D95BF589" modified="2022-01-19" version="1">MSVALCVPAGLCVSQFISFSAGSKLLIFTLSPHSRLGRELELLTRAMALPSAWSAMRLVIPFISVLGLLSVRLVGASQDSGSVIPAESRPCVDCHAFEFMQRALQDLKKMAYNLDTRTETLLLRAEKRGLCDCFPAMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SQ31</accession>
    <name>A0A8C2SQ31_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Gap junction protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">GJA10</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">A connexon is composed of a hexamer of connexins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Gap junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 9">Cell membrane</location>
            <topology evidence="2 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the connexin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SQ31"/>
    <dbReference type="Ensembl" id="ENSCJPT00005003778.1">
        <property type="protein sequence ID" value="ENSCJPP00005002110.1"/>
        <property type="gene ID" value="ENSCJPG00005002275.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286954"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005922">
        <property type="term" value="C:connexin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005243">
        <property type="term" value="F:gap junction channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007267">
        <property type="term" value="P:cell-cell signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050908">
        <property type="term" value="P:detection of light stimulus involved in visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007276">
        <property type="term" value="P:gamete generation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007416">
        <property type="term" value="P:synapse assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.80:FF:000001">
        <property type="entry name" value="Gap junction alpha-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.80">
        <property type="entry name" value="Gap junction channel protein cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000500">
        <property type="entry name" value="Connexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019570">
        <property type="entry name" value="Connexin_CCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017990">
        <property type="entry name" value="Connexin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013092">
        <property type="entry name" value="Connexin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038359">
        <property type="entry name" value="Connexin_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11984">
        <property type="entry name" value="CONNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11984:SF9">
        <property type="entry name" value="GAP JUNCTION ALPHA-10 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00029">
        <property type="entry name" value="Connexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00206">
        <property type="entry name" value="CONNEXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00037">
        <property type="entry name" value="CNX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01089">
        <property type="entry name" value="Connexin_CCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00407">
        <property type="entry name" value="CONNEXINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00408">
        <property type="entry name" value="CONNEXINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0965">Cell junction</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0303">Gap junction</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="210"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Connexin N-terminal" evidence="12">
        <location>
            <begin position="43"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Connexin cysteine-rich" evidence="13">
        <location>
            <begin position="167"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005002110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="321" mass="36641" checksum="4E45CC7767AB289E" modified="2022-01-19" version="1">MGDWNLLGSILEEVHIHSTIVGKIWLTILFIFRMLVLGVAAEDVWDDEQSEFICNTEQPGCSNICYDKAFPISLIRYWVLQIIFVSSPSLVYMAHALYRLRALEKERQKRKAHLRAQLEDLEPMPEEHRRVERELRKLEEQKKVNKAPLRGSLLRTYVLHILTRSVVEVGFMIGQYLLYGFHMSPLYKCTRPPCPNTVDCFVSRPTEKTIFMVFMHSIAAVSLFLNILEIAHLGLKKIHKTLYGRPRQPLGPADDEASPYNSKKNSVVPPASWAQNKISSEGYSAAIVLPVPMQSSGSERDFPCSCGVFIVSTSRFKIETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SSY3</accession>
    <name>A0A8C2SSY3_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SSY3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005004308.1">
        <property type="protein sequence ID" value="ENSCJPP00005002395.1"/>
        <property type="gene ID" value="ENSCJPG00005002582.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000290435"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="268"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="383"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="87"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005002395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="404" mass="38539" checksum="DB9965B1C3685227" modified="2022-01-19" version="1">MPRWRGTIEFSKIIEFLGDTKAAMGRIIELVVGRIIELLGRIIELVGRIIELVEVMGLVVAAMLAALSVVLMAAMLGPVTMLVAAILAAAAMLVIGAMLIVAAILVAAAILVAAILVAAAILVVAAILVAAILVPAAVLVAAAILVAAILVPAAILVAAAILEVAAILVAAILAAAAILVVAAILEVAAILAAAILVVAAILVAAILVAAAILVLAAILVAAILAAAAILVAAAILEVAAILVAAILVAAILVAAILVAAAILAAAAILVAAILAAAAIPVPAAILAAAAILAAIFLPPAILVAAILAAAAILAAILAVAAILAAILAAAAILAAAILAAAAILVAAAILVAIMAAILAAAAILAAILAAAAILAAIFLPPAILVAAILAAAAILAAILVAPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2STU0</accession>
    <name>A0A8C2STU0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Nuclear pore complex protein Nup133</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">NUP133</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Involved in poly(A)+ RNA transport. Involved in nephrogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Forms part of the Nup160 subcomplex in the nuclear pore which is composed of NUP160, NUP133, NUP107 and Nup96. This complex plays a role in RNA export and in tethering Nup98 and NUP153 to the nucleus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
            <location evidence="2">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the nucleoporin Nup133 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015713394.2">
        <property type="nucleotide sequence ID" value="XM_015857908.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2STU0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005006493.1">
        <property type="protein sequence ID" value="ENSCJPP00005003701.1"/>
        <property type="gene ID" value="ENSCJPG00005003844.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107311419"/>
    <dbReference type="KEGG" id="cjo:107311419"/>
    <dbReference type="CTD" id="55746"/>
    <dbReference type="GeneTree" id="ENSGT00390000011529"/>
    <dbReference type="OrthoDB" id="103454at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072006">
        <property type="term" value="P:nephron development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021915">
        <property type="term" value="P:neural tube development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022008">
        <property type="term" value="P:neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048339">
        <property type="term" value="P:paraxial mesoderm development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061053">
        <property type="term" value="P:somite development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000972">
        <property type="term" value="P:transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.700:FF:000001">
        <property type="entry name" value="Nuclear pore complex protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1380:FF:000001">
        <property type="entry name" value="Nuclear pore complex protein Nup133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000238">
        <property type="entry name" value="Nuclear pore complex protein Nup133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007187">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014908">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037624">
        <property type="entry name" value="Nup133-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13405">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13405:SF11">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03177">
        <property type="entry name" value="Nucleoporin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08801">
        <property type="entry name" value="Nucleoporin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117289">
        <property type="entry name" value="Nucleoporin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0137">Centromere</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="10" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like N-terminal" evidence="18">
        <location>
            <begin position="108"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like C-terminal" evidence="17">
        <location>
            <begin position="757"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="27"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00055775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00061981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00068592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF08801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005003701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1175" mass="131131" checksum="93D44F8A54D0F90C" modified="2022-01-19" version="1">MDVIQPRQAGAFALPPFLLPAMFPSAPASPRTPSGSARRALGSAAPSPLSRPGSRKNLSVVAATGSPGLFSPVARRSGSLSARATPTRVIQHPSGSETVNYDVKAFGSALPVKVMEALKKADADDHLSVHVDESGWAWLVHKERLIIWKIGQSPLAKLSLCKELQLPPSDYQWSSSLAAVSCLGSSGDAPSLQSLAIMVATCEGSVRYWPNLAHEGSYTETFADFGGSLCSFLTAVKGGSFILSSSRGQLIRLIPDSTGKIHQHALPQGQGMFSGIGRKVSSLLGILSPGNDAVISSVLWDKERSSFYMLTSSNLNKWEIDSSSERYILSWDVNRVLKEHISDAIWGSESNYEDIKGGVNIQYMDLQQNRDGLVILAAAWHPGDHPCLVYYTLVTVEDKGFQMSDDVVVEVTQYNPSFQSEEEVMCCLVVPDYFSHAAYIYKDDEVFACSTGTGRISLPQEKILFGFQGDSILGAGSYTGLPIFFVKRSGLITILSRENISVLPEDLEDSLSSSIAGPISESPAFDQTSRLEMVAQEDKTKLLKAAFLQYCRKDIVNAQSMVVELFPSNADADSDAELDRAVTQISVDLMDDYPASDPRWAESVPEEASGFSNTSLILLHQLEDKTKAHSFFIDFLHQVGIFERLGSFPVRGMPMATRLLLCEHAEKLAAAIVLKNHHSRLPDLLNAAILIALNKRDCDIPPSLTPADIFFREVSQIDSIFGCLLEEEEQILRETHIESVEWAQVVVNVNNIIKDMLQAACQYRQSRASLYKTGELPEREPEYIPWTASSSVRAAITRQHGIILKVVYPQVDSNLRSIVAEQVVALLDCFLDGYVSQLKSVDRPADQERYSNLEMEYVQKRSELLSPLLSLGQYQMAAALAEKYCDFDILVQMCEQTDNQARLQRYMSQFADQNFSDFLFRWYLEKGKRGKLLSQPIAQHGQLASFLQAHEHLSWLHEINSQDLQKAHRTLQTLANMETRYFAKKKTLLGLSKLAALASDFSEDILQEKIEEIVEQEHFLLHQETLPEQLLVDKQMNLNDMPVLSATQLIDMYICDENRRANEYDFKKALDLLEYIDEEEEVDVNDLKLKILCMALRRDGWSTSEGKDDPIEASKDSIFVKILQKLLKEGVQLSEYLPDVKDFLQADELGSLRYNAYFEFVLKANYEHYVQGQTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SUF2</accession>
    <name>A0A8C2SUF2_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Actin related protein 3B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ACTR3B</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the actin family. ARP3 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SUF2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005005147.1">
        <property type="protein sequence ID" value="ENSCJPP00005002784.1"/>
        <property type="gene ID" value="ENSCJPG00005001362.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158304"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10221">
        <property type="entry name" value="ASKHA_NBD_Arp3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000029">
        <property type="entry name" value="Actin-related protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000315">
        <property type="entry name" value="Actin-related protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000803">
        <property type="entry name" value="Actin-related protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000006">
        <property type="entry name" value="Actin-related protein 3 (ARP3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.36.70:FF:000002">
        <property type="entry name" value="actin-related protein 3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.36.70">
        <property type="entry name" value="Actin, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005002784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="417" mass="47804" checksum="045293DEAD961C37" modified="2022-01-19" version="1">MLWNRLPREVVDAPYTKLGYAGNTEPQFIIPSCIAIRESAKVGDQAQRRVMKGVDDLDFFIGDEAIDKPTYATKWPIRHGIVEDWDLMERFMEQVIFKYLRAEPEDHYFLMTEPPLNTPENREYLAEIMFESFNIPGLYIAVQAVLALAASWTSRQVGERTLTGIVIDSGDGVTHVIPVAEGYVIGSCIKHIPIAGRDITYFIQQLLREREVGIPPEQSLETAKAIKEKYCYICPDIVKEFAKYDGDPRKWIKQYTGINAINKTKFVIDVGYERFLGPEIFFHPEFANPDFMESISDVVDEVIQNCPIDVRRPLYKNVVLSGGSTMFRDFGRRLQRDLKRVVDARLRLSEELSGGRIKPKPVEVQVITHHMQRYAVWFGGSMLASTPEFFQVCHTKKDYEEYGPSICRHNPVFGVMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SUY7</accession>
    <name>A0A8C2SUY7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 17">Receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="2 17">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">ERBB3</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2 17"/>
    <dbReference type="Ensembl" id="ENSCJPT00005005928.1">
        <property type="protein sequence ID" value="ENSCJPP00005003307.1"/>
        <property type="gene ID" value="ENSCJPG00005002126.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156107"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome LGE22C19W28_E50C23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038143">
        <property type="term" value="C:ERBB3:ERBB2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016328">
        <property type="term" value="C:lateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043125">
        <property type="term" value="F:ErbB-3 class receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038132">
        <property type="term" value="F:neuregulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038131">
        <property type="term" value="F:neuregulin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030296">
        <property type="term" value="F:protein tyrosine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021545">
        <property type="term" value="P:cranial nerve development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003197">
        <property type="term" value="P:endocardial cushion development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038133">
        <property type="term" value="P:ERBB2-ERBB3 signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097192">
        <property type="term" value="P:extrinsic apoptotic signaling pathway in absence of ligand"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097049">
        <property type="term" value="P:motor neuron apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042552">
        <property type="term" value="P:myelination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007162">
        <property type="term" value="P:negative regulation of cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000672">
        <property type="term" value="P:negative regulation of motor neuron apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051048">
        <property type="term" value="P:negative regulation of secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009968">
        <property type="term" value="P:negative regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043491">
        <property type="term" value="P:phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070886">
        <property type="term" value="P:positive regulation of calcineurin-NFAT signaling cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055025">
        <property type="term" value="P:positive regulation of cardiac muscle tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014044">
        <property type="term" value="P:Schwann cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd05111">
        <property type="entry name" value="PTK_HER3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12095">
        <property type="entry name" value="TM_ErbB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.220.10:FF:000001">
        <property type="entry name" value="Receptor protein-tyrosine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.220.10:FF:000002">
        <property type="entry name" value="Receptor protein-tyrosine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.20.20:FF:000004">
        <property type="entry name" value="Receptor protein-tyrosine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000233">
        <property type="entry name" value="receptor tyrosine-protein kinase erbB-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000276">
        <property type="entry name" value="Receptor tyrosine-protein kinase erbB-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.220.10">
        <property type="entry name" value="Hormone Receptor, Insulin-like Growth Factor Receptor 1, Chain A, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.20.20">
        <property type="entry name" value="Receptor L-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044912">
        <property type="entry name" value="Egfr_JX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006211">
        <property type="entry name" value="Furin-like_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032778">
        <property type="entry name" value="GF_recep_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000494">
        <property type="entry name" value="Rcpt_L-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036941">
        <property type="entry name" value="Rcpt_L-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016245">
        <property type="entry name" value="Tyr_kinase_EGF/ERB/XmrK_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF88">
        <property type="entry name" value="RECEPTOR TYROSINE-PROTEIN KINASE ERBB-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00757">
        <property type="entry name" value="Furin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14843">
        <property type="entry name" value="GF_recep_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01030">
        <property type="entry name" value="Recep_L_domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000619">
        <property type="entry name" value="TyrPK_EGF-R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00261">
        <property type="entry name" value="FU"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 17 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14 17" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12 17" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="628"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="21">
        <location>
            <begin position="697"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1031"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1096"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1187"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1054"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="1229"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="703"/>
            <end position="711"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="730"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR000619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000619-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005003307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1319" mass="146130" checksum="568E5860949FA2C6" modified="2022-01-19" version="1">MVGGWYWIGDTIGVGGAMVGDTVVLGMLLGLRMLRVCAGTLNGLSVTGDAQHQYRTLHKMYNNCEIVMGNLEIVLIDHSQDLSFLQTIREVTGYILIAMNVFSTLPLRNLRVIRGTQFYEEKYALFVLLNYNPNTTHALRQLGLNHLTEILAGGVYIEKNEQLCHVDTVEWRDIMRDPRLEPVVGDNGRACAPCHESCGGHCWGPGPEDCQQLTKTICAPQCNGRCFGRAPNECCHEECAGGCTGPLQTHCFACRHFNDSGACVPLCPQPLIYNKLTFQLEPNPDTKYQYGSVCVRSCPHNFVVDQSSCVRACPSNKMEVEKNGMKMCEPCAGLCPKGVGITGAAPLPQTVDSRDPWRNISALDPEKLNVFRHSEEITGYLNIQSWPKHMHNFSVFSNLETIGDGPHIPTPSLPLTPPAPNSRGFSLLIMKNDNVTSLGLRSLREVSAGRVYITENRRLCYLHTVQWAALSRRRSDLDIRNNKPRGKCQQEGKVCDPLCSADGCWGPGPAQCLSCRHYSRRGVCVESCSFTQGETREFAEGTECFECHPECERVEGGITCNGSGADTCTRCAHYRDGPHCVERCPEGILGERGPIYKYPDSSQECRPCHENCTRGCTGPLLRDCLGDALPMIAVLVVGGLFLFCSCVLLSLLYWRGKKIQKKRAMRRYLERGESLEPLDPSEKANKVLARIFKETELKRLKVLGSGVFGTVHKGIWIPDGDSIKIPVSIKVIQDWSGQQSFHSVTDHMLAIGSLDHAYIVRLLGICPGPQLQLVTQLLPLGSLLDYVRKNRGSISPQLLLNWCVQVAKGMYYLEEHRMVHRNLAARNVLLKSPSQAQVADFGIADLLYPDDKKYFYNEVKTPIKWMALESIHFGKYTHQSDVWSYGVTLWEMMTFGAEPYAGIRLPEVPDLLEKGERLPQPHICTIDVYMVMVKCWMIDENIRPTFKELANEFTRMARDPPRYLVIKQESGAVPPAEPPTLSDKELDEMETLELEEEELDVSFGLCPPRPRGSCTRVRVGLKGNSDCRLGYPPPNHCHVPQGTGTRPPRRSRQESVGRTVSESSEGRGTASELDLAEGLSLSGSLCRSLRSRGDSAYLSQRESFPPPPPSSEGSEEDANGYVTPSCAGRGEGPSSGGLIPNCEGSLPIPELDEEYEYMNRQPGASLQAPPPRPASLEELGYEYMEVGSELGSPTGPPLGRGEEEEDYEYMNKQPRLSRSLGNMVGGLGPRHEGCPPRHDGYTDMRPGEPTPAPAEEQGYEEMEAVLAPRGPPCPGCRSPPGPPPTCMKPLRSLEASDCAFDNPDYWHSRLFAKVDAQRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SV54</accession>
    <name>A0A8C2SV54_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">KIF5B</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SV54"/>
    <dbReference type="Ensembl" id="ENSCJPT00005006018.1">
        <property type="protein sequence ID" value="ENSCJPP00005003391.1"/>
        <property type="gene ID" value="ENSCJPG00005003582.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154801"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035253">
        <property type="term" value="C:ciliary rootlet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045335">
        <property type="term" value="C:phagocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099524">
        <property type="term" value="C:postsynaptic cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071346">
        <property type="term" value="P:cellular response to type II interferon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051642">
        <property type="term" value="P:centrosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007028">
        <property type="term" value="P:cytoplasm organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032418">
        <property type="term" value="P:lysosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047497">
        <property type="term" value="P:mitochondrion transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160040">
        <property type="term" value="P:mitocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042267">
        <property type="term" value="P:natural killer cell mediated cytotoxicity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072383">
        <property type="term" value="P:plus-end-directed vesicle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043268">
        <property type="term" value="P:positive regulation of potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903078">
        <property type="term" value="P:positive regulation of protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032230">
        <property type="term" value="P:positive regulation of synaptic transmission, GABAergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098987">
        <property type="term" value="P:regulation of modification of synapse structure, modulating synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035617">
        <property type="term" value="P:stress granule disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd23649">
        <property type="entry name" value="Khc_CBD_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01369">
        <property type="entry name" value="KISc_KHC_KIF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000009">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059182">
        <property type="entry name" value="Khc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF68">
        <property type="entry name" value="KINESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 10" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 9 10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="13">
        <location>
            <begin position="8"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="908"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="330"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="418"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="85"/>
            <end position="92"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005003391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="966" mass="110170" checksum="574512D775E99D11" modified="2022-01-19" version="1">MADPAECSIKVMCRFRPLNESEVTRGDKYVAKFQGEDTVVIASKPYIFDRVFQSNTSQEQVYNDCAKKIVKDVLEGYNGTIFAYGQTSSGKTHTMEGKLHDPDGMGIIPRIVQDIFNYIYSMDENLEFHIKVSYFEIYLDKIRDLLDVSKTNLSVHEDKNRVPYVKGCTERFVCSPEEVMDTIDEGKSNRHVAVTNMNEHSSRSHSIFLINVKQENTQTEQKLSGKLYLVDLAGSEKVSKTGAEGAVLDEAKNINKSLSALGNVISALAESSTYVPYRDSKMTRILQDSLGGNCRTTIVICCSPSSYNESETKSTLLFGQRAKTIKNTVCVNVELTAEQWKKKYEKEKEKNKTLRNTIQWLENELNRWRNGETVPVDEQFDKEKANLEAFAVDKDITVINDKPATTIGVTGNFTDAERRKCEEEIAKLYKQLDDKDEEINQQSQLVEKLKQQMLDQEELLASTRRDQDNLQAELNRLQAENDASKEEVKEVLQALEELAVNYDQKSQEVEDKAKEYELLSDELNQKSVTLASIDAELQKLKEMTNHQKKRATEMMASLLKDLAEIGIAVGNNDVKQPEGTGMIDEEFTVARLYISKMKSEVKTMVKRCKQLEGTQAESNKKMEENEKELAACQLRISQHEAKIKSLTEYLQNVEQKKRQLEESVDSLNEELVQLRAQEKVHEMEKEHLNKVQTANEVKQAVEQQIQSHRETHQKQISSLRDEVDAKEKLITELQDQNQKMMLEQERLRVEHEKLKATDQEKSRKLHELTVMQDRREQARQDLKGLEETVARELQTLHNLRKLFVQDLATRVKKSAEIDSDDTGGSAAQKQKISFLENNLEQLTKVHKQLVRDNADLRCELPKLEKRLRATAERVKALESALKEAKENASRDRKRYQQEVDRIKEAVRSKNMARRGHSAQIAKPIRPGQHPAASPTHPSAIRGGGAFTQNSQPVALRGGGGRQDKVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SYZ1</accession>
    <name>A0A8C2SYZ1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]</fullName>
            <ecNumber evidence="3">3.6.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Nucleoside diphosphate-linked moiety X motif 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">NUDT2</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the asymmetric hydrolysis of diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) to yield AMP and ATP. Exhibits decapping activity towards FAD-capped RNAs and dpCoA-capped RNAs in vitro.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>P(1),P(4)-bis(5'-guanosyl) tetraphosphate + H2O = GMP + GTP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:22484"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57553"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="EC" id="3.6.1.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 5'-end CoA-ribonucleoside in mRNA + H2O = a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + (R)-4'-phosphopantetheine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:67592"/>
            <dbReference type="Rhea" id="RHEA-COMP:15719"/>
            <dbReference type="Rhea" id="RHEA-COMP:17276"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="ChEBI" id="CHEBI:144051"/>
            <dbReference type="ChEBI" id="CHEBI:172371"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:67593"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 5'-end FAD-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + FMN + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:67588"/>
            <dbReference type="Rhea" id="RHEA-COMP:15719"/>
            <dbReference type="Rhea" id="RHEA-COMP:17275"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:144051"/>
            <dbReference type="ChEBI" id="CHEBI:172372"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:67589"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.17" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2SYZ1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005009444.1">
        <property type="protein sequence ID" value="ENSCJPP00005005923.1"/>
        <property type="gene ID" value="ENSCJPG00005005599.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000002416"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome Z"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004081">
        <property type="term" value="F:bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006167">
        <property type="term" value="P:AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006754">
        <property type="term" value="P:ATP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03428">
        <property type="entry name" value="NUDIX_Ap4A_Nudt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000037">
        <property type="entry name" value="Nudix hydrolase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051325">
        <property type="entry name" value="Nudix_hydrolase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003565">
        <property type="entry name" value="Tetra_PHTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21340:SF0">
        <property type="entry name" value="BIS(5'-NUCLEOSYL)-TETRAPHOSPHATASE [ASYMMETRICAL]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21340">
        <property type="entry name" value="DIADENOSINE 5,5-P1,P4-TETRAPHOSPHATE PYROPHOSPHOHYDROLASE MUTT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01405">
        <property type="entry name" value="TETRPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="13">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005005923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="208" mass="23832" checksum="5FA333238AA639D5" modified="2022-01-19" version="1">MAVRACGLIIYRRLQPSPSSKAADSIEYLLLQTSYGTHHWTPPKGHVDPGEDDLQTAFRETQEEAGLQASQLTLVEGYRKELQYPVHGKPKTVVYWLAEVKDCNTEIKLSEEHQAFRWLKLEDACRFAEYEDMQATLKDAHQFLSSKKNFLKLEYKKGTEQSEGCFPGKPGAERAATWQLWCTISITSDNRLALIKSCHFYRRVNKAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SZH9</accession>
    <name>A0A8C2SZH9_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Oxaloacetate tautomerase FAHD1, mitochondrial</fullName>
            <ecNumber evidence="5">3.7.1.5</ecNumber>
            <ecNumber evidence="2">4.1.1.112</ecNumber>
            <ecNumber evidence="9">5.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Acylpyruvase FAHD1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Fumarylacetoacetate hydrolase domain-containing protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Oxaloacetate decarboxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">FAHD1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:26168"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16854"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 3-acylpyruvate + H2O = a carboxylate + pyruvate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19009"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57278"/>
            <dbReference type="EC" id="3.7.1.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>acetylpyruvate + H2O = acetate + pyruvate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16097"/>
            <dbReference type="ChEBI" id="CHEBI:15360"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>oxaloacetate + H(+) = pyruvate + CO2</text>
            <dbReference type="Rhea" id="RHEA:15641"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="EC" id="4.1.1.112"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>oxaloacetate = enol-oxaloacetate</text>
            <dbReference type="Rhea" id="RHEA:16021"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:17479"/>
            <dbReference type="EC" id="5.3.2.2"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="8">
            <dbReference type="Rhea" id="RHEA:16023"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.5" evidence="5"/>
    <dbReference type="EC" id="4.1.1.112" evidence="2"/>
    <dbReference type="EC" id="5.3.2.2" evidence="9"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2SZH9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005009432.1">
        <property type="protein sequence ID" value="ENSCJPP00005005912.1"/>
        <property type="gene ID" value="ENSCJPG00005005586.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160452"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018773">
        <property type="term" value="F:acetylpyruvate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047621">
        <property type="term" value="F:acylpyruvate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034545">
        <property type="term" value="F:fumarylpyruvate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008948">
        <property type="term" value="F:oxaloacetate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050163">
        <property type="term" value="F:oxaloacetate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000003">
        <property type="entry name" value="Fumarylacetoacetate hydrolase domain-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF7">
        <property type="entry name" value="ACYLPYRUVASE FAHD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="15">
        <location>
            <begin position="17"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005005912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="222" mass="24712" checksum="6314E2AF5608C6F3" modified="2022-01-19" version="1">MASSRPLTRFWEWGKNIVCVGRNYAEHAKEMGNALPSEPLFFLKPSSAYLREGSPILRPYYCTDLHHEVELGVVIGKRTQAVTKEAAMEHVAGYALCLDMTARDTQKECKKKGLPWTLAKGFSTSCPVSEFVPKEKIPDPHKLKIWLKVNGQLRQEGETSSMIFSIPHLISYISEIVTLEEGDLILTGSPSGVGSVQADDEIEAGIGDILSMRFKVKPNYNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SZN6</accession>
    <name>A0A8C2SZN6_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Angiopoietin 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ANGPT4</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015737426.1">
        <property type="nucleotide sequence ID" value="XM_015881940.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SZN6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005009836.1">
        <property type="protein sequence ID" value="ENSCJPP00005006218.1"/>
        <property type="gene ID" value="ENSCJPG00005005834.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107323139"/>
    <dbReference type="KEGG" id="cjo:107323139"/>
    <dbReference type="CTD" id="51378"/>
    <dbReference type="GeneTree" id="ENSGT00940000160129"/>
    <dbReference type="OrthoDB" id="9933375at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030971">
        <property type="term" value="F:receptor tyrosine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030297">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001525">
        <property type="term" value="P:angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007596">
        <property type="term" value="P:blood coagulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071456">
        <property type="term" value="P:cellular response to hypoxia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016525">
        <property type="term" value="P:negative regulation of angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043537">
        <property type="term" value="P:negative regulation of blood vessel endothelial cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045766">
        <property type="term" value="P:positive regulation of angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043536">
        <property type="term" value="P:positive regulation of blood vessel endothelial cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.215.10:FF:000001">
        <property type="entry name" value="Tenascin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057439">
        <property type="entry name" value="ANG-1/2/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037579">
        <property type="entry name" value="FIB_ANG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020837">
        <property type="entry name" value="Fibrinogen_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47221">
        <property type="entry name" value="FIBRINOGEN ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47221:SF6">
        <property type="entry name" value="FIBRINOGEN ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25443">
        <property type="entry name" value="ANG-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00514">
        <property type="entry name" value="FIBRINOGEN_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0037">Angiogenesis</keyword>
    <keyword evidence="5 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034595861" evidence="9">
        <location>
            <begin position="22"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="10">
        <location>
            <begin position="272"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="183"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="493" mass="55350" checksum="A04BDC6F2B9983EA" modified="2022-01-19" version="1">MSALRLVALAALCTAASQRRAMDVGSRRRWHRVQHGHCSYTFVLPEAEPSPCPLAAPGPVNALQRDSPSGSGHAARGAAQRLQHLERILENSTQWLLKLESSIQSSMKPEVSRLRQTAVQNHTATMLEIGSSLLNRSAEQSRKLTDVEAQVLNQTSRIEMQLLENSLSTTKLEKQLLVQTNEIHRLQSRNNILEVRVLDMEAKHQAELAGIRSEKERLQHLVSRQSGTIEELEKSLLAANANASLLQRQQLQLLESVQSLVRLVAEGRAVLPGEEQRFQDCTEVLRAGSRTSGVYTLHITNLSEPRKAFCDMETDGGGWTVIQLRTNGSVSFQRGWREYKQGFGDAAGEHWLGNEAVHLLTSREPYVLRVELRDWEGSQVYAHYGRFQLDSERQLYRLSLQDYSGTAGQQSSLAMQGTNFSTRDADNDNCLCKCAQMLSGGWWFDACGLSNLNGIYYPARHNVRKLNGIRWHYFQGPSYSLKGTRMLIRPAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SZT5</accession>
    <name>A0A8C2SZT5_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glycoprotein hormone beta-5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Thyrostimulin subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">GPHB5</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Functions as a heterodimeric glycoprotein hormone with GPHA2 able to bind and activate the thyroid-stimulating hormone receptor (TSHR), leading to increased cAMP production. Plays a central role in controlling thyroid cell metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterodimer with GPHA2; this heterodimer interacts with thyroid-stimulating hormone receptor (TSHR), and hence stimulates cAMP production.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycoprotein hormones subunit beta family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015721122.1">
        <property type="nucleotide sequence ID" value="XM_015865636.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SZT5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005008878.1">
        <property type="protein sequence ID" value="ENSCJPP00005005474.1"/>
        <property type="gene ID" value="ENSCJPG00005005234.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107315346"/>
    <dbReference type="KEGG" id="cjo:107315346"/>
    <dbReference type="CTD" id="122876"/>
    <dbReference type="GeneTree" id="ENSGT00730000111179"/>
    <dbReference type="OrthoDB" id="10006958at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031531">
        <property type="term" value="F:thyrotropin-releasing hormone receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002155">
        <property type="term" value="P:regulation of thyroid hormone receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00069">
        <property type="entry name" value="GHB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.90.10:FF:000029">
        <property type="entry name" value="glycoprotein hormone beta-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006208">
        <property type="entry name" value="Glyco_hormone_CN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001545">
        <property type="entry name" value="Gonadotropin_bsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11515">
        <property type="entry name" value="GLYCOPROTEIN HORMONE BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11515:SF14">
        <property type="entry name" value="GLYCOPROTEIN HORMONE BETA-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00007">
        <property type="entry name" value="Cys_knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00068">
        <property type="entry name" value="GHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0372">Hormone</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034041344" description="Glycoprotein hormone beta-5" evidence="12">
        <location>
            <begin position="21"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoprotein hormone subunit beta" evidence="13">
        <location>
            <begin position="34"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00054534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00064459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00079540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005005474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="129" mass="14277" checksum="62E2AC781E3232B9" modified="2022-01-19" version="1">MKLPCVTLGALLLLLPAGHGGTETSAIDLRTFIGCAVREFTFLAKKPGCKVLRITTDACWGRCETWEMPLLKPPYIESYHRVCTYNETKLVTVMLPKCAPGVDPFYTYPVAIRCNCDFCSTSTTECETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T259</accession>
    <name>A0A8C2T259_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Draxin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Dorsal inhibitory axon guidance protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Dorsal repulsive axon guidance protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">DRAXIN</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the draxin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015738202.1">
        <property type="nucleotide sequence ID" value="XM_015882716.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015738203.1">
        <property type="nucleotide sequence ID" value="XM_015882717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T259"/>
    <dbReference type="Ensembl" id="ENSCJPT00005011354.1">
        <property type="protein sequence ID" value="ENSCJPP00005007322.1"/>
        <property type="gene ID" value="ENSCJPG00005006762.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107323526"/>
    <dbReference type="KEGG" id="cjo:107323526"/>
    <dbReference type="CTD" id="374946"/>
    <dbReference type="GeneTree" id="ENSGT00390000013828"/>
    <dbReference type="OrthoDB" id="9931375at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021960">
        <property type="term" value="P:anterior commissure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021528">
        <property type="term" value="P:commissural neuron differentiation in spinal cord"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021516">
        <property type="term" value="P:dorsal spinal cord development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110088">
        <property type="term" value="P:hippocampal neuron apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030517">
        <property type="term" value="P:negative regulation of axon extension"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110091">
        <property type="term" value="P:negative regulation of hippocampal neuron apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03060">
        <property type="entry name" value="Draxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029094">
        <property type="entry name" value="Draxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28610">
        <property type="entry name" value="DRAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28610:SF1">
        <property type="entry name" value="DRAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15550">
        <property type="entry name" value="Draxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035026093" description="Draxin" evidence="5">
        <location>
            <begin position="26"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="37"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="119"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="246"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="140"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005007322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="349" mass="39166" checksum="5CB26C36287EF6A1" modified="2022-01-19" version="1" precursor="true">MAASSTFFFPSLFLCVLLLSDVTLAVSLDTDMKLKNENNNRLQNQETWPQQPRSGHHHKHGLAKKGRVLALPARVQPAGKETLRVGSGAPAMEDLVPLSQPAALKQDKDKDVFLGFELPHAGQENQSPGSERGKKQNREQRRHSRRDRLKHHRGKAAVGPSSLYKKPESFEQQFQNLQAEEATSPTPTVLPFTVLDVVVSTEEPPVLPATSPRSQARLRQDGDVMPTLDMALFDWTDYEDLKPEMWPSAKKKEKRRSKSSNGGNETSSAEGEPCDHHLDCHPGSCCDLREHLCKPHNRGLNNKCYDDCMCTEGLRCYAKFHRNRRVTRRKGRCVEPESANGEQGSFINV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T378</accession>
    <name>A0A8C2T378_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRK SH3-binding GNRP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">RAPGEF1</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T378"/>
    <dbReference type="Ensembl" id="ENSCJPT00005010271.1">
        <property type="protein sequence ID" value="ENSCJPP00005006513.1"/>
        <property type="gene ID" value="ENSCJPG00005005477.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156235"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001568">
        <property type="term" value="P:blood vessel development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070371">
        <property type="term" value="P:ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070373">
        <property type="term" value="P:negative regulation of ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000178">
        <property type="term" value="P:negative regulation of neural precursor cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051898">
        <property type="term" value="P:negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046580">
        <property type="term" value="P:negative regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061351">
        <property type="term" value="P:neural precursor cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043491">
        <property type="term" value="P:phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048008">
        <property type="term" value="P:platelet-derived growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.840.10:FF:000009">
        <property type="entry name" value="rap guanine nucleotide exchange factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019804">
        <property type="entry name" value="Ras_G-nucl-exch_fac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF224">
        <property type="entry name" value="RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00720">
        <property type="entry name" value="RASGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="6">
        <location>
            <begin position="872"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="5">
        <location>
            <begin position="1030"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="220"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="347"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="447"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="712"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="369"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="735"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="747"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="764"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="832"/>
            <end position="843"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00083313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1267" mass="141257" checksum="08F7446D10A58DC3" modified="2022-01-19" version="1">PFLHTEAHKPVISLSLCLWFRSHLSSFTMKLKGKFHSPKIKRTPSKKGKQAELTVKTPEKSANKVIYGNSESFPVVVESLQCAVPDIQTFWIICSEDCCNVSWLEEKEKEVVSALRYFKTIVDKMAIDKKVLEMLPGSASKVLEAILPLVQTDPRIQQSSAISSCYSRVYQSLANLIRWSDQVMLEGVNSEDKEMVTTVKDVIKAVLDGVKELVKLTIEKQEHPSPTSPVKPSLPACKSDSPSELPLTDREMEILNKTTNMTQSNELLTDSMDEEVAPPKPPLPCIRVAENSPPPALPPKKRQSAPSPTRVAVVAPMSRATSGSSLPVGINRQDFDVDCYAQRRLSGGSHSYGGESPRLSPCSSIGKLSKSDEQLSSLDRDSGQCSRNTSCETLDHYDPDYEFLQQDLSNADQIPQQVPGILSPLPESLGESGSPFHGHAFQLPQGSSSPLEFCSPSGAVQPTETPPALPEKKRRSAASQTSDSGCRVSYERHPSQYDNISEDDMQNAGSLSSVSCTPFAPILPFQQGNSSAPVEFIADFAAPDSNSDPEKPPPLPEKKNKHMMAYMQFVEDYSEPQPSMFYQTPQNEHIYQQKNKHLMEVYGFNDSFISLDPSQDLAPPPALPPKQRQLASYAASSFPSVSYCVQQTKVPFTPEDTGATQGLTMSVSNSFLNRHSSFPVHSYKSVFRSYSQDFVPHNQVSVPPFLSSTSSSCSTAPFPPVHPSPSSDLAVPATASPSPSTGDVPNSSSQESSFNGSAPVCLPSETSLTDSLENASEEAGEGEYVNLYSSGQSNGELPHSGGESPSVKDGHSKDSTSNSSAMGKEGKEGAERQQQSPDALESSQLEEEVDELSLIDHSEIMARLTLKQEGDDGPDVRGGSGDILLVHATETDRKDLVLYCEAFLTTYRTFITPEELIKKLQYRYPLHERQLKFCHFPDTFKKRVSKNTFFVLVRVVDELCLVELTEEILKLLMDLVFRLVCNGELSLARVLRKNILDKVDQKKMLRYANSIKPLAARGVAARPGTLHDFHSHEIAEQLTLLDAELFYKIEIPEVLLWAKEQNEEKSPNLTQFTEHFNNMSYWVRSIIMLQEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRLEWQKQTSEGLAEYCTLIDSSSSFRAYRAALADVEPPCIPYLGLILQDLTFVHLGNPDYIDSKVNFSKRWQQFNILDSMRCFQQVHYDIKRNDDIVSFFNDFSDHLAEEALWELSLKIKPRNITRRKTDREEKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T4A6</accession>
    <name>A0A8C2T4A6_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha-1D adrenergic receptor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Alpha-1D adrenoreceptor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">ADRA1D</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with FLNA (via filamin repeat 21); increases PKA-mediated phosphorylation of FLNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015718525.1">
        <property type="nucleotide sequence ID" value="XM_015863039.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T4A6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005011534.1">
        <property type="protein sequence ID" value="ENSCJPP00005007440.1"/>
        <property type="gene ID" value="ENSCJPG00005006860.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107314122"/>
    <dbReference type="KEGG" id="cjo:107314122"/>
    <dbReference type="CTD" id="146"/>
    <dbReference type="GeneTree" id="ENSGT00940000160795"/>
    <dbReference type="OrthoDB" id="5977853at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004937">
        <property type="term" value="F:alpha1-adrenergic receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071880">
        <property type="term" value="P:adenylate cyclase-activating adrenergic receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T5H9</accession>
    <name>A0A8C2T5H9_COTJA</name>
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        <submittedName>
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        <name type="scientific">Coturnix japonica</name>
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        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
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            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
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        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="term" value="P:spermatogenesis"/>
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        <property type="entry name" value="Znf_FCS"/>
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        <property type="entry name" value="POLYCOMB GROUP PROTEIN"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ZF_FCS"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FCS-type" evidence="11">
        <location>
            <begin position="352"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="10">
        <location>
            <begin position="521"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
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            <begin position="1"/>
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        </location>
    </feature>
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            <end position="493"/>
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            <begin position="13"/>
            <end position="29"/>
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    </feature>
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            <end position="271"/>
        </location>
    </feature>
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    </evidence>
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        </source>
    </evidence>
    <sequence length="585" mass="62509" checksum="17FECCFA7F61E3FD" modified="2022-01-19" version="1">MENEQVPAPPPSSSAGSTGTTPSSTGTTRPPAPQISVYSGIPDRQTVQVIQQALHRQPNTAAQYLQQMYAAQQQHLMLQTAALQQQHLTSAQLQSLAAVQQASLAANRQSGSSGSNGTQQAPVQQPTINLATSPAAAQLLNRAQSVNPGASGIAQQAVLLGNAASPALTASQAQMYLRAQMVRGAWPRGTVGQLGPTGWQCKVSTDPQEADAIGSPLPHSSYSCALTVPSSRPPPPAEPGAERVDAPPAAPAPGMTSGSGSAASTVAGAAPHNGENKPPQAVVKPQILTHVIEGFVIQEGAEPFPVGRSSLLVGGLKPQYAQELLAERAPQHDNTTTTDSEMEEPYLQESKEEGAPPKLKCELCGRVDFAYKFKRSKRFCSMACAKRYNVGCTKRVGLFHPDRSKLQKPGVPPHGRRRACKVPTLSKDTKKQTPVSLPPGSGPLSVTASLQLNHSQEDSSRCSDNSSYEEPLSPISASSSASRRRQAERDLELHDMELPDMHVRELAGIGHRFLPSEPSKWNVEDVYEFIRSLPGCQEIAEEFRAQEIDGQALLLLKEDHLMSTMNIKLGPALKIYARISMLKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T5Q5</accession>
    <name>A0A8C2T5Q5_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Neuromedin U receptor 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">NMUR2</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Receptor for the neuromedin-U and neuromedin-S neuropeptides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015731093.1">
        <property type="nucleotide sequence ID" value="XM_015875607.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T5Q5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005012045.1">
        <property type="protein sequence ID" value="ENSCJPP00005007865.1"/>
        <property type="gene ID" value="ENSCJPG00005007135.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107320102"/>
    <dbReference type="KEGG" id="cjo:107320102"/>
    <dbReference type="CTD" id="56923"/>
    <dbReference type="GeneTree" id="ENSGT01120000271823"/>
    <dbReference type="OrthoDB" id="5950040at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005229">
        <property type="term" value="F:intracellularly calcium-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042924">
        <property type="term" value="F:neuromedin U binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001607">
        <property type="term" value="F:neuromedin U receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050482">
        <property type="term" value="P:arachidonate secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007625">
        <property type="term" value="P:grooming behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007200">
        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002023">
        <property type="term" value="P:reduction of food intake in response to dietary excess"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048265">
        <property type="term" value="P:response to pain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd15357">
        <property type="entry name" value="7tmA_NMU-R2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005390">
        <property type="entry name" value="NeuromedU_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005392">
        <property type="entry name" value="NeuromedU_rcpt_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045561">
        <property type="entry name" value="NMU-R2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF14">
        <property type="entry name" value="NEUROMEDIN-U RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19285">
        <property type="entry name" value="NmU-R2_C_term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01565">
        <property type="entry name" value="NEUROMEDINUR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01567">
        <property type="entry name" value="NEUROMEDNU2R"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 12" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 12" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="164"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="209"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="266"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="303"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="15">
        <location>
            <begin position="59"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="373"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="378"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005007865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="395" mass="44927" checksum="3FA22A4157D44D30" modified="2022-01-19" version="1">MAWISNSSWFNHLVLQEHFRRYLNSTEDYLAFLCGPKRSHLFLPMALVYSVIFVVGVIGNFLVCLVILKHRNMKTPTNYYLFSLAVSDLLVLLFGMPLEVYEMWSNYPFLFGPIGCYFKTALFETVCFASILSVTTVSVERYFAILHPFRAKLESTRKRALRTIVVLWVLSVLFALPNMGTHGIMLQYFPNGTMVPGSATCTVVAPMWIYNWIVQITSFLFYVLPMGVISVLYYLMGLRLKGDRSLEAEEMSVNVQRPSRKSVTKMLFVLVMVFAVCWAPFHIDRLFFSFVVEWTEPLANIFNLIHVVSGVFFYLSSAVNPIIYNLLSQRFRMAFLSVISPGCKRWAPKQAASKTPAQQSIFMVEDHNLVDSAEDTSVPGTNRTSVSSSQLSTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T5T9</accession>
    <name>A0A8C2T5T9_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Attractin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="primary">ATRN</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="27" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="27" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Involved in the initial immune cell clustering during inflammatory response and may regulate chemotactic activity of chemokines. May play a role in melanocortin signaling pathways that regulate energy homeostasis and hair color. Low-affinity receptor for agouti. Has a critical role in normal myelination in the central nervous system.</text>
    </comment>
    <comment type="subunit">
        <text evidence="17">Monomer and homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSCJPT00005012962.1">
        <property type="protein sequence ID" value="ENSCJPP00005008564.1"/>
        <property type="gene ID" value="ENSCJPG00005007640.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157346"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021549">
        <property type="term" value="P:cerebellum development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042552">
        <property type="term" value="P:myelination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043473">
        <property type="term" value="P:pigmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040014">
        <property type="term" value="P:regulation of multicellular organism growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000031">
        <property type="entry name" value="attractin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000034">
        <property type="entry name" value="Attractin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.100.10:FF:000012">
        <property type="entry name" value="Attractin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000079">
        <property type="entry name" value="Attractin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000164">
        <property type="entry name" value="Attractin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000008">
        <property type="entry name" value="Attractin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056737">
        <property type="entry name" value="Beta-prop_ATRN-MKLN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056732">
        <property type="entry name" value="GBD_ATRN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056863">
        <property type="entry name" value="LMN_ATRN_NET-like_EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051568">
        <property type="entry name" value="LZTR1/Attractin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002165">
        <property type="entry name" value="Plexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016201">
        <property type="entry name" value="PSI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46376:SF3">
        <property type="entry name" value="ATTRACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46376">
        <property type="entry name" value="LEUCINE-ZIPPER-LIKE TRANSCRIPTIONAL REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24981">
        <property type="entry name" value="Beta-prop_ATRN-LZTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24973">
        <property type="entry name" value="EGF_LMN_ATRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24972">
        <property type="entry name" value="GBD_ATRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01437">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00423">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50027">
        <property type="entry name" value="EGF_LAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11 19" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 19" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0395">Inflammatory response</keyword>
    <keyword evidence="2" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="15 20" id="KW-0424">Laminin EGF-like domain</keyword>
    <keyword evidence="7" id="KW-0430">Lectin</keyword>
    <keyword evidence="10 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 22" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="1275"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="24">
        <location>
            <begin position="69"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="23">
        <location>
            <begin position="104"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="24">
        <location>
            <begin position="218"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="26">
        <location>
            <begin position="767"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="25">
        <location>
            <begin position="1031"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="21">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="21">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="222"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="245"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="1048"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="1060"/>
            <end position="1074"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00058400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00065783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00074596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005008564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1318" mass="146790" checksum="C3FDD2D9DD50DE04" modified="2022-01-19" version="1">MVLVVPPPPGRPSSRSRSRRQMARRGPAWRVGRPQRLLLALLLLLLPAVPGLGPAATAAADEKEEDGGTAKECDKPCANGGRCQPGTGQCECQPGWVGDQCQHCGGRFRLTEPSGYVTDGPGNYKYKTKCTWLIEGRPNTILRLRFNHFATECSWDHLYVYDGDSIYAPLLAAFSGLIVPEKDSNETVPEVVATSGYALLHFFSDAAYNLTGFNITYNFNMCPNNCSGRGECRLSNSTNALECECAKYWKGEACDIPYCTDDCGAPERGFCNFNETKACVCSAGWQGPGCSVPVPADRSFWTREEYSLPKLPRASHKTIIHDNKMWVVGGYVFNHSDSQKVLAYDLISEEWLPLNNTVNSVEMRYGHSLALHKDDIYMYGGKIDATGNVSSQLWVFNIPRQSWTLAAPKAKEQYAVVGHSAHIVTLEDKSVVMLVIFGHCPLYGYISNVQEYNLATNTWSILQTSGALVQGGYGHSSVYDPHTRSIYIHGGYKAFSANKYRLADDLYRYEVDSKMWTILKDSRFFRYLHTAVIMSGTMLVFGGNTHNDTSMSHGAKCFSSDFMAYDIACNKWSVLPRPGLHHDVNRFGHSAVLYNSTMYIFGGFNSLLLSDILKYTPERCEAFANESSCMHAGPGVRCVWAPALPGCVPWEMATVQQQQKVLEDCPAKSVVDNEKCDQITDCYSCTANTNSCQWCTDQCISMHNNCTEEQVPITAYENCPKDNPAYYCNKRTSCKSCAMDQNCQWEPRNQECIALPENICGTNWHLVSNSCLKITNAKENYDHAKLSCRSIGASLASLTTQKKVEFVLKELQKMQSSSKALTPWVGLRKINVSYWCWEDMSPFTNTLLQWLPEEPSDAGFCGYLAEPTNQGLKAATCINEVNGSVCERAANHSAKQCRTPCALRTMCGECTSGSSECMWCSNMKQCVDSNAYVASFPYGQCMEWYTMSSCPPENCSGYCTCSHCLEQPGCGWCTDPSNTGKGKCIEGAYRGAVKFPTPSATGKQSLEPVLNVSMCPAEHSSNWSFIQCPACQCNGHSKCINESICEKCENLTTGKHCETCISGYYGDPTNGGTCQPCKCNGHASVCNTNTGKCFCTTKGIKGDECQLCEVENRYQGNPLKGTCYYTLLIDYQFTFSLSQEDDRYYTAINFVATPEEQNRDLDMFINASKNFNLNITWATSFAAGTQAGEEIPVVSRTNIKEYKDSFSNEKFDFRNNPNITFFVYVSNFTWPIKIQIAFSQHSNFMDLVQFFVTFFRYISLQTAQCFCFIFFPSRFVLQCSVCFSVVVVVVVVVAPLIKHPAYMTAQKMEIPTVFKAFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T6J6</accession>
    <name>A0A8C2T6J6_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Copine-8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Copine VIII</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">CPNE8</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the copine family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015707187.1">
        <property type="nucleotide sequence ID" value="XM_015851701.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T6J6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005013671.1">
        <property type="protein sequence ID" value="ENSCJPP00005009118.1"/>
        <property type="gene ID" value="ENSCJPG00005008073.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107308100"/>
    <dbReference type="KEGG" id="cjo:107308100"/>
    <dbReference type="CTD" id="144402"/>
    <dbReference type="GeneTree" id="ENSGT00940000159679"/>
    <dbReference type="OrthoDB" id="5855668at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071277">
        <property type="term" value="P:cellular response to calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04048">
        <property type="entry name" value="C2A_Copine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04047">
        <property type="entry name" value="C2B_Copine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01459">
        <property type="entry name" value="vWA_copine_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000071">
        <property type="entry name" value="Copine 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000013">
        <property type="entry name" value="copine-9 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037768">
        <property type="entry name" value="C2B_Copine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045052">
        <property type="entry name" value="Copine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010734">
        <property type="entry name" value="Copine_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10857">
        <property type="entry name" value="COPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10857:SF133">
        <property type="entry name" value="COPINE-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07002">
        <property type="entry name" value="Copine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="C2" evidence="9">
        <location>
            <begin position="16"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="9">
        <location>
            <begin position="156"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="10">
        <location>
            <begin position="323"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00057254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00074840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00075514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005009118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="578" mass="64744" checksum="11831365F49B5DBE" modified="2022-01-19" version="1">MFGLEKPPGQQKLDRSGGFPNMASVGDFNVLSSSIPATKVELSVSCRNLLDRDTFSKSDPICVLYTQAIGNKEWREFGRTEVIDNTLNPDFVRKFIMDYFFEERENLRFDFYDVDSKSPNLSKHDFLGQMFCTLGEIVGSQGSRLEKPITGIPGKKCGTVIVTAEELGCCRDSVLMQFCANKLDKKDFFGKSDPFLVFHRSNEDGSFTICHKTEVVKNTLNPVWQAFKISVRALCNGDYDRTIKVEVYDWDRDGSHDFIGEFTTSYRELSRGQSQFNVYEVINPKKKGKKKKYVNSGTVTLLSFLIETEVSFLDYIKGGTQINFTVAIDFTASNGNPSQPTSLHYMNPYQLNAYGMALKAVGEIIQDYDSDKMFPALGFGARLPPDGRVSHEFALNGNPQNPYCHGIDGVMEAYYRSLKSVQLYGPTNFAPVINHVARYAASVKDGSQYFVLLIITDGVISDMAQTKESIVNASKLPMSIIIVGVGPAEFDAMEELDGDVVRISSRGKFAERDIVQFVPFRDYIDRSGNHVLSMARLAKDVLAEIPEQFLSYMRVRGIKPSPAPPPYTPPIHVLQTQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T7Q0</accession>
    <name>A0A8C2T7Q0_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Period circadian regulator 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PER3</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T7Q0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005012523.1">
        <property type="protein sequence ID" value="ENSCJPP00005008215.1"/>
        <property type="gene ID" value="ENSCJPG00005007394.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160817"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019900">
        <property type="term" value="F:kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001222">
        <property type="term" value="F:transcription corepressor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032922">
        <property type="term" value="P:circadian regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043153">
        <property type="term" value="P:entrainment of circadian clock by photoperiod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045187">
        <property type="term" value="P:regulation of circadian sleep/wake cycle, sleep"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000013">
        <property type="entry name" value="Period circadian protein homolog 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000004">
        <property type="entry name" value="Period circadian protein homolog 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057310">
        <property type="entry name" value="PER1-3_bHLH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048814">
        <property type="entry name" value="Per1-3_PAS-A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022728">
        <property type="entry name" value="Period_circadian-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050760">
        <property type="entry name" value="Period_circadian_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11269">
        <property type="entry name" value="PERIOD CIRCADIAN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11269:SF13">
        <property type="entry name" value="PERIOD CIRCADIAN PROTEIN HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23170">
        <property type="entry name" value="bHLH_PER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21353">
        <property type="entry name" value="Per3-like_PAS-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12114">
        <property type="entry name" value="Period_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="PAS" evidence="10">
        <location>
            <begin position="229"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="660"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="843"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="897"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="664"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="687"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="726"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="856"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="897"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="912"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="925"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="938"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="949"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="978"/>
            <end position="993"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005008215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1098" mass="122035" checksum="2142FF2F51BB9263" modified="2022-01-19" version="1">MVTIQEIKKCLPEEKRSPSKPSTISALNYALRCVQQVRANNEFFQALNDRRMFQTDVMTYSTEELVTVASEHTPKNSDTFVAVFSLLSGRIVHISEQAASILNHKKKVLESSRFVELLAPQDASVFYAHTDQSHLPLWNTESQTASLYEYAQVKSFFCRIRGGRDQEQETHWYPFRITPYLVHVCTSVHVDAESCCLALAEKIHSGYEAPRIPMDKRIFTTTHTPGCVFLEVDDRAVPLLGYLPQDLIGTSILMYLHPEDRPLMIAIHHKILKLAGQPPFEYLPIRFCTQNGDYVILDTSWSSFVNPWSRKVAFIIGRHKVRTSPLNEDVFATRSQETSSVEKEIKELQGQIYRLLLQPVHSNVSSGYGSLGSSGSYEHYISVASSSDSNGNCAEETQEPMTLQQVCADVNRIKNLGQQLYIASRSKTQHGNGQPMSSEVLEGKRHDASCFLPTLRSDSAEELGNALHGDSKKAPHVPSYQQLNCVDSIIRYLESCSIPLLKRKCKSSTNTSSSSSDGDKKNQQRLQEIKALGVFADEEEMLKKQTNEGTVRAPLPDLTLSNKSPSVVSATSQCSYSSTIVHVPHPESEVTIMENTPFRNEHIELPPLNAQNPVTVAEELKPVGLTKETLSAHTQKEEQNYVDKFRQRILLSPFRTYLQRDSRSTNGHSCDQGNSPSKEMIPASCKNGKKGKLKHQKPQRRSSDRRFFSKNRNGLPSEKRRIQKQLLSPSEASHLSSSSTNLFPPVGFPVYSDALSSFAASSVGEELAICSSKPELTSLSQLCCGAPSFPALSPPNIGMFMAVFLHSFPIYTQMPQYVFLPGTQNVYLPSSYPCTAVPHAPPPPAPSPIVPDSVDQSCPVSSATSTEEQPEGQHGQVLQLSSSRSSSPLQLNLLQEELPESVEPSVSTDVKACAEAERDNSLEDSGNSASSHCASSEFTDRLLHEDSQSGAGSAASGSGLALSSSLGPQSCEAGTETEQEKKEEETPHKSEHESAWVMMDRTPEQVLMTYQMPNRIKEEVLKEDMEKLIVMRKQQPWFSDRQKRELAEVHTWIQTQTVPLQISTQGCVTCDIREATYETTMADDNMENKGKPLPVLEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T8G6</accession>
    <name>A0A8C2T8G6_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="4">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">TENT2</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>RNA(n) + ATP = RNA(n)-3'-adenine ribonucleotide + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11332"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17347"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="ChEBI" id="CHEBI:173115"/>
            <dbReference type="EC" id="2.7.7.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the DNA polymerase type-B-like family. GLD2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="4"/>
    <dbReference type="RefSeq" id="XP_015704097.1">
        <property type="nucleotide sequence ID" value="XM_015848611.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T8G6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005013566.1">
        <property type="protein sequence ID" value="ENSCJPP00005009041.1"/>
        <property type="gene ID" value="ENSCJPG00005008009.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107305917"/>
    <dbReference type="CTD" id="167153"/>
    <dbReference type="GeneTree" id="ENSGT00940000156640"/>
    <dbReference type="OrthoDB" id="2274644at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome Z"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002244">
        <property type="term" value="P:hematopoietic progenitor cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071044">
        <property type="term" value="P:histone mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000626">
        <property type="term" value="P:negative regulation of miRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140958">
        <property type="term" value="P:target-directed miRNA degradation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1410.10:FF:000007">
        <property type="entry name" value="poly(A) RNA polymerase GLD2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000022">
        <property type="entry name" value="poly(A) RNA polymerase GLD2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF40">
        <property type="entry name" value="POLY(A) RNA POLYMERASE GLD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="16">
        <location>
            <begin position="168"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="PAP-associated" evidence="15">
        <location>
            <begin position="394"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005009041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="492" mass="56354" checksum="37A54FEB35C50E20" modified="2022-01-19" version="1">MFPNSSNLGRPPFPPKYQHRNNFLNKVPLNIQPIVSHQQIINARINFQNAMASLSGNLVTTLAGMPQPLVYGNGSPVNTPSPSPTFRGKKRLSEQSVPFGVKRQRYRSPHRETHAVNQAVPSPEQSARLFSGCNARYVPDLGIHVPRLQDILFPPVTETTLPVAKDKLSLQVLKLFEACQQQTCDLNRKELCRSELQREIQRIFPCSRLFLVGSSLNGFGTRTSDGDLCLVVTEEPVNQKTEARHILSLVHKLFSTKLSRYIERPQLIRAKVPIVKFRDKVSCVEFDLNVNNIVGIRNTFLLRTYAYVEKRVRPLVLVVKKWASFHDINDASRGTLSSYSLVLMVLHYLQTLPEPILPSLQKNYPESFDPTMQLNLVHQAPCTIPPYLSKNESSLGELLIGFFKYYATEFDWNHQIISVREAKAIPRPDDAEWRNKYICVEEPFDRTNTARAVHEKQKFDIIKEEFLKSWQILKDKKDLSFVLPLKATIQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TBK8</accession>
    <name>A0A8C2TBK8_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sulfate transporter-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC107320347</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015731575.1">
        <property type="nucleotide sequence ID" value="XM_015876089.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TBK8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005014938.1">
        <property type="protein sequence ID" value="ENSCJPP00005010043.1"/>
        <property type="gene ID" value="ENSCJPG00005008787.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107320347"/>
    <dbReference type="KEGG" id="cjo:107320347"/>
    <dbReference type="GeneTree" id="ENSGT01150000286920"/>
    <dbReference type="OrthoDB" id="288203at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00815">
        <property type="entry name" value="sulP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="480"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="7">
        <location>
            <begin position="535"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="710"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005010043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="730" mass="81008" checksum="4CAE708CCC9A4D8B" modified="2022-01-19" version="1">MENKSSQTSRQSSLTQGEPPVGFTHIRLEENEPIKFRTKDFILNKAREVCKCNHQTIITFFCHLFPVLDWLPRYNIKTQLLGDVISGLLVGIVAIPQSISYSLLASQDPIYGIYTNFFSGIIYVAMATSRHNSVGSFGVLCLMIGQSVNRHLQIAGYDDDTGSLLVGNATSSNNGTDTCDRSCYAITVALSLSFLVGLYQILLGVLQLGFVSVYLSEPLLSGFVVGSSLTIITSQMKYLLGLNIPRHEGVGSFILTWVDLFRYIQNTNICDLVTSLVALAIIIPVKMINDRYKDKMKAPLPVELFVVIIATVVSHYFKFEERYKSSVCGAIPTGFMKPTLPDIKLFSSLAVDALPIAIIGFAMTVSLAEIFGKKHGYPVSANQEMIAIGMCNLVPSFFYCFASSAALTKTLLKESTGTHTQLSSLVTSLVLLLVLLWVAPLFYSLQTAILGVVTIVNLRGGLRAFCETPRMWQLSKLDTVVWWITMLASTLITTEIGLLVGVCFALLCVIFRTQRPRAALLGKVSNTEIYEDQSAYKQLSSIANIKIFRFESSLYYANKDYFKTALYQKTGVNPVLLAARHQRAETKAKADTGNRKSIINTVFGCLKPSKKHNEKSPTDICLPSIDMHTLIIDCGAMQFIDTTGLSMLKEMHRDYQELGVQVLLANCNPLLRRRLRDGGWAAGPPGDQLAFHSVHHAVQFAQQWYHEKQENKERRDAALDPEELSFQASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TC31</accession>
    <name>A0A8C2TC31_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Myosin IF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">MYO1F</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015742117.1">
        <property type="nucleotide sequence ID" value="XM_015886631.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TC31"/>
    <dbReference type="Ensembl" id="ENSCJPT00005016719.1">
        <property type="protein sequence ID" value="ENSCJPP00005011457.1"/>
        <property type="gene ID" value="ENSCJPG00005009837.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107325593"/>
    <dbReference type="KEGG" id="cjo:107325593"/>
    <dbReference type="CTD" id="4542"/>
    <dbReference type="GeneTree" id="ENSGT00940000158870"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005902">
        <property type="term" value="C:microvillus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01378">
        <property type="entry name" value="MYSc_Myo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11827">
        <property type="entry name" value="SH3_MyoIe_If_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.4820:FF:000004">
        <property type="entry name" value="Myosin IE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000007">
        <property type="entry name" value="Myosin IE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000101">
        <property type="entry name" value="Slow myosin heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000072">
        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.720:FF:000010">
        <property type="entry name" value="Unconventional myosin-Ie"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035507">
        <property type="entry name" value="Ie/If_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010926">
        <property type="entry name" value="Myosin_TH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036072">
        <property type="entry name" value="MYSc_Myo1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF663">
        <property type="entry name" value="UNCONVENTIONAL MYOSIN-IF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06017">
        <property type="entry name" value="Myosin_TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51757">
        <property type="entry name" value="TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="8 11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="7 11" id="KW-0518">Myosin</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="Myosin motor" evidence="14">
        <location>
            <begin position="17"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="domain" description="TH1" evidence="15">
        <location>
            <begin position="728"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="13">
        <location>
            <begin position="1042"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="11">
        <location>
            <begin position="567"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="915"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="939"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="1029"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="110"/>
            <end position="117"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005011457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1099" mass="126212" checksum="FCF786797CB15C76" modified="2022-01-19" version="1">MGSKERFHWQSHNVKQSGVDDMVLLAKISEEAIVENLKKRFMDDYIFTYIGPVLISVNPFKQMPYFTDREIELYQGAAQYENPPHIYALTDNMYRNMLIDGENQCVIISGESGAGKTVAAKYIMGYISKVSGGGDKVQHVKDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSRGGEPDGGKISNFLLEKSRVVNQNEHERNFHVYYQLIEGASQEQRQNLGIMSPDYYYYLNQSDTYQVEGTDDRSDFLETMNAMQVIGIRGEDQQLVLQIVAGILHLGNISFREEGNYARVENADSLAFPAYLLGIDRDRLNDKITSRKMDSKWGGRSESITVTLNVEQAAYTRDALAKGLYARVFDFLVESINRAMQKPYEEYSIGVLDIYGFEIFQKNGFEQFCINFVNEKLQQIFIELTLKAEQEEYVQEGIKWTQIQYFNNKVVCDLIENKLNPPGIMSVLDDVCATMHATGEGADQTLLQKLQAAVGTHEHFNSWSSGFVIHHYAGKVSYDVNGFCERNRDVLFTDLIELMQSSEYAFIRMLFPEKLDADKKGRPTTAGSKIKKQANDLVNTLMKCTPHYIRCIKPNETKKPRDWEESRVKHQVEYLGLKENIRVRRAGFAYRRIFHKFLQRYAILTPETWPSWRGDERQGVQHLLRSVNMDPDQYQMGRSKVFVKNPESLFLLEEMRERKFDGFARVIQKAWRRHVAIRKYEQMREEASNILYNFKERRRNSINRNFVGDYLGMEERPELRQFLAKRERIDFADSITKYDRRFKPIKRDFILTPKYFYLIGREKVKKGPEKGQIKEVLKKKVEIQAVSGVSLSTRQDDFFILHEKDADSFLESIFKTELVSLLCKRYEELTRSKLHLNFQDTLQFRVKKEGWGGGGTRTVTFTRGQGDVAALKAGGKTLTVSIADGLPRNSKPTRKGVMQSKGGSRRPPPPRSAPPAPQGTYRNGAPQFPRGDAQPKRDTYTTPQKQARAPPATALPPQNANRRSKARPPSEQNMEFLNVPDQGVAGMQRRRSVGQRPPPASRPKPQPKAAMPRCRALYQYIGQDVDELSFNVGDVIDILLEDISGWWKGRLHGREGLFPGNYVQKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TC43</accession>
    <name>A0A8C2TC43_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uroplakin 3B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">UPK3B</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TC43"/>
    <dbReference type="Ensembl" id="ENSCJPT00005016663.1">
        <property type="protein sequence ID" value="ENSCJPP00005011410.1"/>
        <property type="gene ID" value="ENSCJPG00005009801.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153392"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024831">
        <property type="entry name" value="Uroplakin-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15446">
        <property type="entry name" value="UROPLAKIN III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15446:SF15">
        <property type="entry name" value="UROPLAKIN-3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005011410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="257" mass="26888" checksum="09761B5E469B7DA0" modified="2022-01-19" version="1">ASWPVTCCHPAVPLYLMGLCVAGGLPLTAVPPALLPYVPRVAPGAMVGKVTATTFVLERPRCVFDPFSNASDAVWLVVAFADASTAFKNPTSSSEVPPYEGLPTARAYMTLEMAAATYGCSAPGPAVLRVGADTTCHSRAPCNGPLPSPGPYRVKFLLMGCSGPKAETKWSEPIVLRRGTGGSGAETTTPTPKGGRAPQCPHVTPHHVPFQLALCVPLCCRDLGAHLPYRTHHVPPALPHTLPPACICGCTPWPRGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TCD1</accession>
    <name>A0A8C2TCD1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Small ribosomal subunit protein uS17m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">28S ribosomal protein S17, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">MRPS17</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015735981.1">
        <property type="nucleotide sequence ID" value="XM_015880495.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015735982.1">
        <property type="nucleotide sequence ID" value="XM_015880496.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TCD1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005017065.1">
        <property type="protein sequence ID" value="ENSCJPP00005011692.1"/>
        <property type="gene ID" value="ENSCJPG00005010031.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107322451"/>
    <dbReference type="KEGG" id="cjo:107322451"/>
    <dbReference type="CTD" id="51373"/>
    <dbReference type="GeneTree" id="ENSGT00530000064130"/>
    <dbReference type="OrthoDB" id="274752at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00364">
        <property type="entry name" value="Ribosomal_uS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000137">
        <property type="entry name" value="28S ribosomal protein S17, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_uS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039193">
        <property type="entry name" value="Ribosomal_uS17m_metazoa"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24088">
        <property type="entry name" value="28S RIBOSOMAL PROTEIN S17, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24088:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US17M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00070246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00078462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005011692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="137" mass="15449" checksum="34259FC9C2399587" modified="2022-01-19" version="1">MSVPRGAVHAKWIVGKVIGTKMQKTAKVRVTRLVLDPYLLKFFNKRKTYFAHDPLQQCVVGDIVLLKALPERRSKHVKHELAEIVFKVGNVIDPITGKPCAGTRFLENLSDSENLTEADTTYLSEKLQELKVCSTDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TDT3</accession>
    <name>A0A8C2TDT3_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Carbohydrate sulfotransferase</fullName>
            <ecNumber evidence="11">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">CHST9</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Golgi apparatus membrane</location>
            <topology evidence="1 11">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the sulfotransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="11"/>
    <dbReference type="RefSeq" id="XP_015710984.1">
        <property type="nucleotide sequence ID" value="XM_015855498.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015710985.1">
        <property type="nucleotide sequence ID" value="XM_015855499.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TDT3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005016748.1">
        <property type="protein sequence ID" value="ENSCJPP00005011474.1"/>
        <property type="gene ID" value="ENSCJPG00005009853.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005016749.1">
        <property type="protein sequence ID" value="ENSCJPP00005011475.1"/>
        <property type="gene ID" value="ENSCJPG00005009853.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107310134"/>
    <dbReference type="KEGG" id="cjo:107310134"/>
    <dbReference type="CTD" id="83539"/>
    <dbReference type="GeneTree" id="ENSGT00940000160563"/>
    <dbReference type="OrthoDB" id="2019940at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001537">
        <property type="term" value="F:dermatan 4-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016051">
        <property type="term" value="P:carbohydrate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030166">
        <property type="term" value="P:proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018011">
        <property type="entry name" value="Carb_sulfotrans_8-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005331">
        <property type="entry name" value="Sulfotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137:SF6">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03567">
        <property type="entry name" value="Sulfotransfer_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044679378" description="Carbohydrate sulfotransferase" evidence="12">
        <location>
            <begin position="27"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005011474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="411" mass="48116" checksum="45567B6BE21D5E19" modified="2022-01-19" version="1">MNVRQVFVSLLMFGVAGLLLFMYLQAWTEEQNTVSGEKLQQQITIQDFMLPPPETQRRVTQSSHIPPVLGRQEVAIMDSQQWQGKADLFGAVAVSLVPGLSDHQKISKLPFSQFKEVYLPPVLHPLNKTLVTGDQWKDVDSIQEKRRSFLYEFCKKYNSMKKLRTHLVHIVSRIYVEDRHKVLYCEVPKAGCSNWKRVLMVLNGLATSVRNISHDDVHYGKHLRKLDSYDLKGIYTRLNTYTKTIFVRDPLERLVSAFRDKFEHPNSYYHPVFGKAIIKKYRHNANKEALETGSGVKFKEFIQYLLDSHRPVGMDIHWEQVSKLCYPCLINYDFIGKFETLEEDANYFLQLVGAPAELKFPRFKDRHSSDERTSAEVVRQYLKELSKEERQLTYDFYYLDYLMFNYTSPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TEF7</accession>
    <name>A0A8C2TEF7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Group XIIB secretory phospholipase A2-like protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Group XIII secretory phospholipase A2-like protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">sPLA2-GXIIB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">PLA2G12B</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Not known; does not seem to have catalytic activity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phospholipase A2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TEF7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005016494.1">
        <property type="protein sequence ID" value="ENSCJPP00005011255.1"/>
        <property type="gene ID" value="ENSCJPG00005009694.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000008798"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050482">
        <property type="term" value="P:arachidonate secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042632">
        <property type="term" value="P:cholesterol homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070328">
        <property type="term" value="P:triglyceride homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.90.10:FF:000003">
        <property type="entry name" value="Group XIIB secretory phospholipase A2-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.90.10">
        <property type="entry name" value="Phospholipase A2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010711">
        <property type="entry name" value="PLA2G12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036444">
        <property type="entry name" value="PLipase_A2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12824">
        <property type="entry name" value="GROUP XII SECRETORY PHOSPHOLIPASE A2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12824:SF2">
        <property type="entry name" value="GROUP XIIB SECRETORY PHOSPHOLIPASE A2-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06951">
        <property type="entry name" value="PLA2G12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48619">
        <property type="entry name" value="Phospholipase A2, PLA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034121145" description="Group XIIB secretory phospholipase A2-like protein" evidence="12">
        <location>
            <begin position="30"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00055969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00076135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00076881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005011255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="207" mass="23128" checksum="1F53F83E50D6F60A" modified="2022-01-19" version="1">GSLLSRSLPQMRLLLEAAVLCLTLHLGHCTEETTQENTAQTSDTESFLPEWGIGAIRGSFETVNSYFDSFLELLGGKNGVCQYRCRYGKAPMPRPHYKPQEPNGCSSYFLGLKLDLGIPAMTKCCNQLDVCYDTCGANKYRCDAKFRWCLHSICSDLKRSLGFVSKVEACESIADTVFNAVWTLGCRPFMNSQRSACICSEEERDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TH80</accession>
    <name>A0A8C2TH80_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Chromatin assembly factor 1 subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">CHAF1A</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CHAF1A family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TH80"/>
    <dbReference type="Ensembl" id="ENSCJPT00005017607.1">
        <property type="protein sequence ID" value="ENSCJPP00005012128.1"/>
        <property type="gene ID" value="ENSCJPG00005010320.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00440000034888"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033186">
        <property type="term" value="C:CAF-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070087">
        <property type="term" value="F:chromo shadow domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021644">
        <property type="entry name" value="CAF-1_p150_acidic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029105">
        <property type="entry name" value="CAF1-p150_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029091">
        <property type="entry name" value="CAF1_p150_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022043">
        <property type="entry name" value="CAF1A_DD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15272:SF0">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15272">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT A CAF-1 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15539">
        <property type="entry name" value="CAF1-p150_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15557">
        <property type="entry name" value="CAF1-p150_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11600">
        <property type="entry name" value="CAF1A_acidic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12253">
        <property type="entry name" value="CAF1A_dimeriz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromatin assembly factor 1 subunit p150 N-terminal" evidence="13">
        <location>
            <begin position="2"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Chromatin assembly factor 1 p150 subunit acidic region" evidence="10">
        <location>
            <begin position="390"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="Chromatin assembly factor 1 subunit A dimerization" evidence="11">
        <location>
            <begin position="510"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="Chromatin assembly factor 1 subunit p150 C-terminal" evidence="12">
        <location>
            <begin position="615"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="28"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="232"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="326"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="550"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="729"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="883"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="232"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="255"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="550"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="570"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="732"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="886"/>
            <end position="900"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF11600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF15539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF15557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005012128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="913" mass="102352" checksum="7FA3EA4601F36AFE" modified="2022-01-19" version="1">FVAMECRDKAVVPPRRLVQARLPFKRLNPVPKEKDDAEAEGKKGKSCKGGLGQSKDSSTDTSHASMDNMENDCQLNSDVNFVPKLVNGKGPLDYFIQKGTKDNTDEIIVIIDSVDESHQRLGDDVDHVNLDSKASTATLTNGVIGKDMNELDCLNSTQNNQTDESMETDVRCEAIANKGEDLVDGIQSCSELTECNNLENTKVNQGELKDIIFEGKMPVVLLEDIMAAKSPQVTSLDGSVTSENETVELSHEGDSVLTNSSLSSLSVSSPEAQPVAETKRNTSPLAVSTPVRKVGLFSWLFKTYYMVDGLFDQERADKLQKLQAEREEKERLKEEAKAAKERAKEEAKKRKEEEKELKEKERREKKEKEEKEKAEKLRVKEEKRKERQERINAQKAEITRFFQKPKTPQAPKILAGSCGKFAPFEIKENMVLAPLCRIALYPDFLEQLDQLLRAQNSEVSFLRDLKCRKPRRTGPTFVNNSTDIVNSDVVVVDNCKTDAVPERGKFGRMKLLQFCENHRPAYWGTWNKKTTMIRPRNPWSKDSKLLDYEVDSDEEWEEEEPGESLSHSEGDDEEEGEDEDDDDGFFVPHGYLSEDEGVTEECDPENQKVRQKLKAKEWDELMAKGKRLHVLQPVKIGCIWESSQNDSGTNADLKVLQQFTACILDSSVAEEEQQIQKCSKKRAKDQQILGQLLPLLHGNVNGSKVIIQEFQECCRQGLFSDVTAAADCGDTSPVSPNTSRPQTPVGEDSGVPSKARLKRIISENSVYEKRPEYRMCWYVHSEVLKSFDQEHLPVPCQWNYITQVPSSGKEDGGGVPGVATVQSTPMSVKRKSTGSMCITKFMKRPRDAEQAEAMEMDGFQADTEEDEDDDDCMIVDVQPCKDSTLTASETAPEPSATTAAHQDANMVSPSNTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2THV3</accession>
    <name>A0A8C2THV3_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ubiquitin-ribosomal protein eL40 fusion protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">UBA52</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the ubiquitin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015742197.1">
        <property type="nucleotide sequence ID" value="XM_015886711.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2THV3"/>
    <dbReference type="SMR" id="A0A8C2THV3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005019907.1">
        <property type="protein sequence ID" value="ENSCJPP00005013898.1"/>
        <property type="gene ID" value="ENSCJPG00005011684.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107325632"/>
    <dbReference type="KEGG" id="cjo:107325632"/>
    <dbReference type="CTD" id="7311"/>
    <dbReference type="GeneTree" id="ENSGT00940000153593"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 28"/>
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        <property type="term" value="C:cytosolic large ribosomal subunit"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01803">
        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000014">
        <property type="entry name" value="Ubiquitin-60S ribosomal L40 fusion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1060.50:FF:000001">
        <property type="entry name" value="ubiquitin-60S ribosomal protein L40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001975">
        <property type="entry name" value="Ribosomal_eL40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038587">
        <property type="entry name" value="Ribosomal_eL40_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01020">
        <property type="entry name" value="Ribosomal_L40e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01377">
        <property type="entry name" value="Ribosomal_L40e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="11">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00035298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005013898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="128" mass="14728" checksum="7BCB602ABEFAD02A" modified="2022-01-19" version="1">MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGIIEPSLRQLAQKYNCDKMICRKCYARLHPRAVNCRKKKCGHTNNLRPKKKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TIW9</accession>
    <name>A0A8C2TIW9_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">WD repeat-containing protein 81</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">WDR81</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasmic vesicle</location>
            <location evidence="5">Autophagosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Early endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Late endosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Lysosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the WD repeat WDR81 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TIW9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005019196.1">
        <property type="protein sequence ID" value="ENSCJPP00005013346.1"/>
        <property type="gene ID" value="ENSCJPG00005011274.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00930000151039"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070530">
        <property type="term" value="F:K63-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141039">
        <property type="term" value="F:phosphatidylinositol 3-kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035973">
        <property type="term" value="P:aggrephagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045022">
        <property type="term" value="P:early endosome to late endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000341">
        <property type="entry name" value="WD repeat-containing protein 81 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000355">
        <property type="entry name" value="WD repeat-containing protein 81 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052651">
        <property type="entry name" value="WDR81"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44662">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44662:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="10" id="KW-0967">Endosome</keyword>
    <keyword evidence="14" id="KW-0458">Lysosome</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="8 18" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="18">
        <location>
            <begin position="594"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="38"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="482"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="69"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="496"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00060735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00070555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005013346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="893" mass="97165" checksum="8A3F6758AD854A02" modified="2022-01-19" version="1">GLREPHSSTALDLLDYTSGVSFHDQAYLPESEDFQSGLYVGESLQPQEQESLSLGRLSDKSSASEVSLGEDRPADGDSQKDKSSLKSVDSSQDLKQSEDSEEEEEERDEEEHDDTAVEAELVGAVDVGVSVDAGTSVDVTLADDGSEPEDGEGEELPDHSDDKEQTILLDTACKMVRWLSAKLGPTVTSRFIARNLLRLLTSCYVGPTRQQFVPSSDENGPLSTGNIYQKRPVLGDQVSKPVLACLLHMAYLYGEPVLTYQYLPYISYLVASGGGSGGGWLNSRKEAGLLAAVTLTQKIVVCLSDTTLMDILPKISQEVLLPVLGFLTSLSVGFPSGAQARVVLCVKTISLIALICLRIGQEMVQQHLSDTVRNFFGAFSLLQELQDQGLTAESLSGCEVPVMEVPLMEGKLLALDPAVLMELQKVFNPEMAYITYIPFSCLLGDVIRTVVPNHSLVEKLASLYLENVNPKNLQVVGLEQAPGMAGSDQDTRGTEAFSSPQEDSQSGTFGSVLVGNRIQVPMDTQREGLGLLHLSAGTDGFNPSLSSEENTLKHDLPRSTHMLCGNWLAYWQYEIGVSQHDPRFHFHQIKLQSFSGHSGAIKCVAPLSSEDFFLSGSKDKTVRLWPLYNYGDGTSEVPPRFTYSEHKKSVFYVSQLEASQHVVSCDGTVHIWDQFTGKLIRTFDELDSKAPITAVTTMPPPYHSISVASADSVLRFIDHRKPGLQHEFRLASGVNAGLIRCLAVSPNGRSVMAGFSSGFIVLLDTRTGLIMRGWPAHEGDILQIKAAEGNVLISSSSDHSMTVWKELEQKPLHHYKSASEPIHAFDLYGNEVVTGTVANKIGVYSMLESSALPVSTTKLSSENFRGTLTSLAVLPMKCHLLLGSDNGVIRLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TKA7</accession>
    <name>A0A8C2TKA7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Galanin receptor type 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC107319203</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Receptor for the hormone galanin. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Interacts with GRP39 AND HTR1A.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015729363.1">
        <property type="nucleotide sequence ID" value="XM_015873877.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032302984.1">
        <property type="nucleotide sequence ID" value="XM_032447093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TKA7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005021137.1">
        <property type="protein sequence ID" value="ENSCJPP00005014908.1"/>
        <property type="gene ID" value="ENSCJPG00005012389.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107319203"/>
    <dbReference type="KEGG" id="cjo:107319203"/>
    <dbReference type="GeneTree" id="ENSGT01150000286969"/>
    <dbReference type="OrthoDB" id="2132067at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004966">
        <property type="term" value="F:galanin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd15098">
        <property type="entry name" value="7tmA_Gal1_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000135">
        <property type="entry name" value="galanin receptor type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000405">
        <property type="entry name" value="Galanin_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF25">
        <property type="entry name" value="GALANIN RECEPTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00663">
        <property type="entry name" value="GALANINR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 16" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="9 16" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 16" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 16 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="18">
        <location>
            <begin position="59"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00053116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00063558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00074701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005014908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="363" mass="40544" checksum="11B1919739336638" modified="2022-01-19" version="1">MEEEEDSFMLFLGANTSNCSLKTNETGDPPCWSGAAKGGPEVVIVPVLFGFIFLLGMVGNTLVLVVLGRLRPGGRPSRSATNIFILNLSIADFSFLLFCVPFQATIYSLPEWIFGAFFCKWVHYLAMATMLVSIFTLVAMSVDRYIAVVHAKRSSGIRSKRNAALGVGVIWLLSLLIAIPVAQHQALMSGHQQAPNSSFCWENWAEGSTAKQTYKVMILLVGYLLPLVLITCCYAKVLYHLHTKVKNISKKSERSKKKTAQTVLLVVAVFLLSWLPHHIITMWAEFGHFPLNNISFTFRIISHCLAYGNSCINPIIYAFLSENFRKACQQAFNCKCFLQPVPTEKLVRIRMENFSTTHSTTNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TKW5</accession>
    <name>A0A8C2TKW5_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Estradiol 17-beta-dehydrogenase 2-like</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TKW5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005019783.1">
        <property type="protein sequence ID" value="ENSCJPP00005013803.1"/>
        <property type="gene ID" value="ENSCJPG00005011600.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163363"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05325">
        <property type="entry name" value="carb_red_sniffer_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF38">
        <property type="entry name" value="C-FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005013803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="272" mass="28778" checksum="828A7C8BA9A620A0" modified="2022-01-19" version="1">MGELRVRSALVTGANRGIGLGFVRHLLALPNPPEWVFAGCRDPKGQRAQVSKLALKHPNLVMQVTDPASIKAAAASVGERLKGSGLNLLINNAGIVRANKLDNETLKDMSEVYMTNTIAPLLLSQAFLPLLKKAAQGSPGSGLSCNKAAIVNISSNGGSIKEVYLWEGIQAACYRCSKVCAVFETKCQSMGYRETRHLHCSFHPSDGCKTDLGYEGGGTPPLTVDASVGGMLKVLSNLSDKDSALPGPGKGTLWPVFAWSVPPGFAHKPILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TL03</accession>
    <name>A0A8C2TL03_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">poly(ADP-ribose) glycohydrolase</fullName>
            <ecNumber evidence="2">3.2.1.143</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">PARG</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the poly(ADP-ribose) glycohydrolase family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.143" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2TL03"/>
    <dbReference type="Ensembl" id="ENSCJPT00005021492.1">
        <property type="protein sequence ID" value="ENSCJPP00005015134.1"/>
        <property type="gene ID" value="ENSCJPG00005012368.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000003652"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004649">
        <property type="term" value="F:poly(ADP-ribose) glycohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990966">
        <property type="term" value="P:ATP generation from poly-ADP-D-ribose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009225">
        <property type="term" value="P:nucleotide-sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006282">
        <property type="term" value="P:regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046372">
        <property type="entry name" value="PARG_cat_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048362">
        <property type="entry name" value="PARG_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007724">
        <property type="entry name" value="Poly_GlycHdrlase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12837">
        <property type="entry name" value="POLY ADP-RIBOSE GLYCOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12837:SF15">
        <property type="entry name" value="POLY(ADP-RIBOSE) GLYCOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05028">
        <property type="entry name" value="PARG_cat_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20811">
        <property type="entry name" value="PARG_cat_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PARG helical" evidence="8">
        <location>
            <begin position="611"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="domain" description="PARG catalytic Macro" evidence="7">
        <location>
            <begin position="735"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="224"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="313"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="408"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="243"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="446"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="766"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="784"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="785"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="769"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="783"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="824"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR607724-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR607724-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1008" mass="113956" checksum="31C72C33C3F83B5E" modified="2022-01-19" version="1">MDHSDIWFNPLLARSQPAAPSCRAIQPGLECLQGWGIHSLLGQPVPVRHHPLGAKPNLIQPKPALSQFKTIPPCPVSIQCSCAVVLQCHYASCSNVVRCGFSACKQRTITTWLENKGSKTTESRSLQSKINNNTEENTKMTSVKKENACEHDDKQLENICQQNYPEISGEVGTKHVSLPQTGSMCNWEAEGRDLDSDRVSVKAEQTEEAFKNANMDQMHRTGKEAQRRCEDSGDIWTQRKRSSGQSLRTGNTKLCSKDPETDGQVGLCGSQKLKSCDSVDAGEQEEGDVVPESPLSDTGCDACVSRVGGHEKLSKCRSSSGDSPAFEKESEPESPMDVDNSKNSCHGSEADEETSPLLDEREENNMAKPINKSYRIQYGDVELESRKSRFSTKGCEGFEGMDNSVKDDGLHIKPPGMSPAPTLESKGAKPGAKKDSKITSHFMRIPKTEEKSRKDKCEFKPQRAGRKIPKYEPPPLPTNKKWFGTPIEEMRRMPMCGARLPHLRPSANHTVTVRVDLLKEGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGDRTAGSRWELIQTALLNKFTCSHDLKEAILRYNVAYAKKWDFTALTDFCDKVLEDAEAQHLFQSILPDMVKLALCLPTICTQPIPLLKQKMNHSITMSQEQIASFLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSPRKPEKLKTLFCYFRRVTERKPTGLVTFTRQCLQEFPDWERSQKKLSRLHVTYEGTIESNGQGMLQVDFANRFVGGGVTGAGLVQEEIRFLINPELIVSRLITEVLDHNECLIITGTEQYSEYTGYAETYRWARSHEDKTPRDEWQRRYTEIVAIDAFHFRRFLDQFGPEKIRRELNKAYCGFSRPNVPPQNLSAIATGNWGCGAFGGDSRLKALIQILAAAEAGRDIVYFTFGDVELMRDIYSMHTFLCEKNQTVGDIYRLLLRYYNEECRTCSTSGPEVKLYSFIYNTIESYADSTDDDEEKGLCFED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TLR0</accession>
    <name>A0A8C2TLR0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">L-threonine 3-dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="5">1.1.1.103</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC107312408</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate, mediating L-threonine catabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-threonine + NAD(+) = (2S)-2-amino-3-oxobutanoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13161"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78948"/>
            <dbReference type="EC" id="1.1.1.103"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid degradation; L-threonine degradation via oxydo-reductase pathway; glycine from L-threonine: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.103" evidence="5"/>
    <dbReference type="RefSeq" id="XP_015715305.1">
        <property type="nucleotide sequence ID" value="XM_015859819.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TLR0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005022305.1">
        <property type="protein sequence ID" value="ENSCJPP00005015791.1"/>
        <property type="gene ID" value="ENSCJPG00005013038.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107312408"/>
    <dbReference type="KEGG" id="cjo:107312408"/>
    <dbReference type="GeneTree" id="ENSGT00390000014037"/>
    <dbReference type="OrthoDB" id="10058185at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008743">
        <property type="term" value="F:L-threonine 3-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd05272">
        <property type="entry name" value="TDH_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000077">
        <property type="entry name" value="L-threonine 3-dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051225">
        <property type="entry name" value="NAD(P)_epim/dehydratase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42687">
        <property type="entry name" value="L-THREONINE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42687:SF1">
        <property type="entry name" value="L-THREONINE 3-DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="7">
        <location>
            <begin position="58"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00050613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00059023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00060557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00066604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00069940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="373" mass="41443" checksum="CD2191FBBFC71E10" modified="2022-01-19" version="1">MPVIRNLSRAVSQLLQNPACGCGVSIVPVRCIGISPRQVASDASFHSVSFSESDHPRVLITGGLGQLGVGLAKLLRKRFGKNNVILSDIRKPADHVFHSGPFIYSDILDYKNLREIVVNNRITWLFHYSALLSAVGEANVPLARAVNITGLHNVLDIAAEHNLRLFVPSTIGAFGPTSPRDPTPDLCIQRPRTIYGVSKVHAELMGEYYHYRYGLDFRCLRYPGIISADSQPGGGTTDYAVQIFHDAIKTGKFECNLKPDTRLPMMYIDDCLKATLEVMEAPAEALSMRTYNISAMSFTPEELAQEVQKHVPELQVTYNVDAVRQAIADSWPMNFDDSNARRDWGWKPDYDLPELVSTMFSFLGSDSRIAQAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TM15</accession>
    <name>A0A8C2TM15_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tetratricopeptide repeat protein 27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TTC27</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TTC27 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TM15"/>
    <dbReference type="Ensembl" id="ENSCJPT00005019631.1">
        <property type="protein sequence ID" value="ENSCJPP00005013690.1"/>
        <property type="gene ID" value="ENSCJPG00005011386.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00500000044929"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044244">
        <property type="entry name" value="TTC27/Emw1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16193">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16193:SF0">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="589"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="623"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005013690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="905" mass="102918" checksum="AEFC6CAFA49EB5F8" modified="2022-01-19" version="1">MWARVRQLLGACSFPSRLRRATSRRARRDCHGGVLRPLPSHGLRGRRQRAAFGASEAERGHCGSAMLGLERSLLRGFLSQAESQEWKQGEISATESGSILQLIFDGKYEAIFSNAAIQNVFSASSVVEEDIESYLEKQILMYLDCSAEVDNLERQRLMFLLGVGSLQLFVQSNWTGPPVHLQLQDILPSALLQKCLEPKMLHATILKMLVLDAESVYTLTSHPVLLLIARVILVNLRDKLSSLQTLPWWTLRCVNIHQQLLEERSPQLFTLAQMCIRDMTEAEALFAGDESWHLAVQFNLECAYTFLYYYEYKKAKQCFSTAKDIAKLQINLTGALGKRTRFQEKYVAQLILDVQRSEEFIPPHSELTPAPTPLENLAMNCDLNDDTILNEIKLADADRYQVPDLCAEELATEFVLENGVKNLTFLSFKLLFSLQCLLSQPKFWAIQTSALLLRTKLEKGSTRRMERAMKQTQALADQFEDAKTSVSERMKIFYCCQVSPHWAIQRQLASLLFELGCTSSALQIYEELEMWEDAVICYERAGQHGKAEEILRRELEKKETPGLYCLLGDVLKDHQCYDKAWELSRHRSARAQRSKGLLHLRNREFRECIECFERSVQINPMQLGVWFSLGCAYIALEGYEGAAKAFQRCVTLEPDVCTFQQAIQMAYLKATRIIKAFRTLQEALKCNYEHWQIWENYLFTSTDVGEFSEAIKAYHRLMDLREKYKDTQVLAILVRAVVDGIGGRTGEAASGLKGKLKELLGRVTSRVTNDGEIWRLYAQLYGNGQNDSIEDMEKSLQCLTKAHKCEIQSNDWEKDVSAFKEVAKGAIEIAHVAIKCSKNKSNHQEALQILSSARLNLRGLSSKAKQRFVDVGSHEICSEIADEVTTMDNLIAELQELSNQLRDQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TPP8</accession>
    <name>A0A8C2TPP8_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transmembrane BAX inhibitor motif containing 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TMBIM1</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TPP8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005022397.1">
        <property type="protein sequence ID" value="ENSCJPP00005015846.1"/>
        <property type="gene ID" value="ENSCJPG00005013088.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01050000244890"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001234">
        <property type="term" value="P:negative regulation of apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10428">
        <property type="entry name" value="LFG_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="BAX INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291:SF35">
        <property type="entry name" value="PROTEIN LIFEGUARD 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="455"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="485"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="512"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="542"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="572"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="605"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="51"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="210"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="286"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="630" mass="68583" checksum="3C670015804BB0A3" modified="2022-01-19" version="1">MKDVTCSNLHLYPIPIRKEPPRALHPAPAYRIMARCGMRLEERSWWVGTDTRGQNKGEQPWRPLAFNLSSPPRRQRFRRSPPSASRRESPADPSSTHPRRKTSGPASAMITAAARRAMRRSAGQRPSQAATPSPHVTTPTASTARQRAPAMPLSRPRHAPPPSRQPIGERRDSVARPLRRSRHHFARPLPEGFPRVTSLREGGPRGCRGRGPPWGRGAACPRGAQPHRGTVGRPRLPSLPRGCRRDAPLGTDPPRSVPAPLPCTGAVARGRAAAGRPGAGRLLSVPPDPPRQPCPGPSRPSSSPAKQRSRCPAGQLAAGMAQPSAPPPYDDKNPLYPPSAYPQPSHYAGGYPQPGGYPAPAGYAAPGGYGTPGGYPQPGMAMPTMPMRFGDTYGGDGIGGSSPIQTADWDDRKVRHTFIRKVYAIISVQLLVTVGIIAMFTFVSPVRSFVQRNAAIYYASYAVFLVTYLVLVCCQGPRRRFPWNIILLSIFTLAMGFMTGTIASMYRTNAVLIAMIITAIVAIIVTIFCFQTKVDFTSCPGLFCVLGIVVMVTGLVTVIVLSFKYVPWLHMLYAAIGAIAFTLFLAYDTQLVLGNRKNTLSPEEYIYGALTIYTDIIYIFTFLLQIVGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TQ79</accession>
    <name>A0A8C2TQ79_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Ras-related protein Rab-43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">RAB43</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Phagosome membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Golgi apparatus</location>
            <location evidence="12">trans-Golgi network membrane</location>
            <topology evidence="12">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TQ79"/>
    <dbReference type="Ensembl" id="ENSCJPT00005022045.1">
        <property type="protein sequence ID" value="ENSCJPP00005015565.1"/>
        <property type="gene ID" value="ENSCJPG00005012876.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161980"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033106">
        <property type="term" value="C:cis-Golgi network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033116">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030670">
        <property type="term" value="C:phagocytic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007193">
        <property type="term" value="P:adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090382">
        <property type="term" value="P:phagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903358">
        <property type="term" value="P:regulation of Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035526">
        <property type="term" value="P:retrograde transport, plasma membrane to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019068">
        <property type="term" value="P:virion assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01864">
        <property type="entry name" value="Rab19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000803">
        <property type="entry name" value="Ras-related protein Rab-43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048040">
        <property type="entry name" value="Rab19/43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00067841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="245" mass="26616" checksum="CAC1925E173EC000" modified="2022-01-19" version="1">MEARAALRGAAGAAQSPAPLGGGGHKAEGRSAMPGPAVPSPDPEESYDFLFKLVLIGDASVGKTCLVQRFKTGAFAERQGSTIGVDFTMKSLEIQGKRVKLQIWDTAGQERFRTITQSYYRSANGAILAYDISKRGSFLSIPRWIEDVRKYAGSNIVQLLIGNKSDLSDLREVQLEEAQNLADHYDNIICAIETSAKDSSNVEEAFVKMATELMMRHGGPMFSEKNTDSIKLDSKDVVEGWGCGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TQU8</accession>
    <name>A0A8C2TQU8_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Contactin associated protein family member 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">CNTNAP5</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May play a role in the correct development and proper functioning of the peripheral and central nervous system and be involved in cell adhesion and intercellular communication.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the neurexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015724320.1">
        <property type="nucleotide sequence ID" value="XM_015868834.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005022328.1">
        <property type="protein sequence ID" value="ENSCJPP00005015805.1"/>
        <property type="gene ID" value="ENSCJPG00005013048.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107316848"/>
    <dbReference type="KEGG" id="cjo:107316848"/>
    <dbReference type="CTD" id="129684"/>
    <dbReference type="GeneTree" id="ENSGT00940000160532"/>
    <dbReference type="OrthoDB" id="26719at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1000:FF:000005">
        <property type="entry name" value="Contactin associated protein-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000016">
        <property type="entry name" value="Contactin-associated protein-like 4 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000026">
        <property type="entry name" value="contactin-associated protein-like 4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050372">
        <property type="entry name" value="Neurexin-related_CASP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036:SF46">
        <property type="entry name" value="CONTACTIN-ASSOCIATED PROTEIN-LIKE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036">
        <property type="entry name" value="PIKACHURIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01285">
        <property type="entry name" value="FA58C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01286">
        <property type="entry name" value="FA58C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 11" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034121152" evidence="14">
        <location>
            <begin position="23"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1238"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="15">
        <location>
            <begin position="23"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="16">
        <location>
            <begin position="180"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="16">
        <location>
            <begin position="368"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="17">
        <location>
            <begin position="547"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="18">
        <location>
            <begin position="583"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="16">
        <location>
            <begin position="792"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="17">
        <location>
            <begin position="958"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="16">
        <location>
            <begin position="1018"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="930"/>
            <end position="957"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1306" mass="145818" checksum="82B4E212D942E703" modified="2022-01-19" version="1">MDSPALGAVALLFAGFWHLGLTATNYNCDGTLVSTLPSSAFTSSSEFFSTHSPSFAKLNRRDGAGGWSPLDSNEQQWLQVDLGDRVEIVGVATQGRYGSSDWVTSYTLMFSDTGRNWKQYRKDDTIWVFTGNSNADSVVHHKLPHSMKARFLRFVPLKWNAGGHIGLRVEVFGCSYKSDIADFDGRSSLLYRFNQKLMSTFKDVVSLKFKSMQEDGVLFHGEGQRGDYITLELQKGKLSLHINLGDSNLHFTNSHTSITLGSLLDDQHWHSVLIERFNKQVNFTVDKHTQHFRTKGDSDHLDIDYELSFGGIPVPGKPGTFQRKNFHGCIENLYYNGVNIIDLAKRRKPQIYTVGNVTFFCSEPQIVPITFVSSSRSYLLLPGTPQIDGLSVSFQFRTWNKDGLLLSTELSENSGSLLVYLHGGRLTLLIQKVAEDPVEISEGTNLHDGLWHSLNINARRHRITLTLDNNAASASHATTVSRIYSGNSYYFGGCPDNFTDSQCLNPTAAFQGCMRLIFIDNQPKDLILVQQGSLGNFSDLHIDLCDIKDRCLPNYCEHGGKCSQSWTTFYCDCNDTSYMGATCHNSIYEQSCEAYRHQGKTSDFFYIDSDGSGPLGPLRVFCNITEDKIWTAVQHNNTGLTRVQGAGPEKPYTMSFNYNSSAEQLEAVINSAEYCEQEAAYYCKKSRLLNTPNGMPFAWWVGRANEKHLYWGGSLPGIQQCACGLEESCLDMRYFCNCDADREEWTNDTGLLGFKDHLPVTQIVITDTNRSNSEAAWKIGPLRCYGDRQFWNAASFNTEASYLHFPTFHAEVSADISFFFKTTSLSGVFLENLGMKDFIRVEIRSPKEITFSIDVGNGPTEATVQSPTPLNDNQWHYVRAERNLKQTSLQVDNLPKKVLEAPAEGHFRLQLNSQLFVGGTASRQKGFLGCIRSLHLNGQKLDLEERAKMTPGVKPGCPGHCSSYGNLCHNGGKCVEKYNGYSCDCTSSAYEGPFCKEEVSALFEAGTSITYIFQEPYPVTKNASTSSSAIYADAIMSKENIAFSFLTAHAPSLLLYINTYFHEYLAVILSKNGSLQVRYKLSKDGLLIFTIDSGNFANREMHHVKINREGRELIIQVDQVIKLKHNFSEIDFKAIKSLTLGKVTDSLSLDPEVSKANAYGFTGCMSSVWYNHIAPLKAALRHPSIAPVTVKGSLTESSCSSLMEADVNTATTIYSSSDPFGKTDEREPLTNAVRSDSAVIGGVIAVVIFIIFCIIAIMSRFLYQHKQAHRSSQTKEKEYPENLESSFKADIDLQNTVSECKREYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TRA0</accession>
    <name>A0A8C2TRA0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">ZNRF2</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="RefSeq" id="XP_015709508.1">
        <property type="nucleotide sequence ID" value="XM_015854022.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TRA0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005021990.1">
        <property type="protein sequence ID" value="ENSCJPP00005015514.1"/>
        <property type="gene ID" value="ENSCJPG00005012849.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107309323"/>
    <dbReference type="KEGG" id="cjo:107309323"/>
    <dbReference type="CTD" id="223082"/>
    <dbReference type="GeneTree" id="ENSGT00940000159017"/>
    <dbReference type="OrthoDB" id="10057496at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001650">
        <property type="term" value="C:fibrillar center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160177">
        <property type="term" value="P:positive regulation of autophagosome-lysosome fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070936">
        <property type="term" value="P:protein K48-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16695">
        <property type="entry name" value="mRING-CH-C4HC2H_ZNRF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000363">
        <property type="entry name" value="E3 ubiquitin-protein ligase ZNRF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051878">
        <property type="entry name" value="ZNRF_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46661">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ZNRF1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46661:SF3">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ZNRF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0967">Endosome</keyword>
    <keyword evidence="16" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="15" id="KW-0458">Lysosome</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0519">Myristate</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 17" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="19">
        <location>
            <begin position="190"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="18">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="42"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="233" mass="23303" checksum="2FD66F5F107FBC59" modified="2022-01-19" version="1">MGAKQSSPTAANGRTRAYSGGDLPSSSGGGGGGANGTGGRAASGRYPHLAAAPHGAHGGSAAAAATGGAAGTAPRSRSLGGAGAAARAAQSAFNIPHSSGPYGSQDSVSSTPEEGGRDRPAGGGGSAGGPRLVIGSLPAHLSPHLFGGFKCPVCSKFVSSDEMDLHLVMCLTKPRITYNEDVLSKDTGECAICLEELQQGDTIARLPCLCIYHKGCIDEWFEVNRSCPEHPSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TTF2</accession>
    <name>A0A8C2TTF2_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SH2 domain containing 2A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">SH2D2A</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TTF2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005023907.1">
        <property type="protein sequence ID" value="ENSCJPP00005017114.1"/>
        <property type="gene ID" value="ENSCJPG00005014002.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107324420"/>
    <dbReference type="KEGG" id="cjo:107324420"/>
    <dbReference type="CTD" id="9047"/>
    <dbReference type="GeneTree" id="ENSGT00940000161903"/>
    <dbReference type="OrthoDB" id="67310at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000103">
        <property type="entry name" value="Si:ch73-109i22.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14388:SF9">
        <property type="entry name" value="SH2 DOMAIN-CONTAINING PROTEIN 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14388">
        <property type="entry name" value="T CELL-SPECIFIC ADAPTER PROTEIN TSAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="SH2" evidence="4">
        <location>
            <begin position="135"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="229"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="384"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="279"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005017114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="456" mass="49682" checksum="BDCF6B072AF4F7F2" modified="2022-01-19" version="1">MQLAASCPSPCCKAAPALPTPRPPGPGGGRGGSMDDTQPLFITFKCIAEDKAGNIQPGHGTTLLQPQSIIEQCDAHSRGGQGAMEGPQPPIAPCHVLQGCSQPGGVAASLRARTKLWFEQTQAHRLRAAGNLPAWFHGFISRRDTEKMLQNEPLGCFLIRFSESTVGFVLSYRGRERCRHFVLDQLPNGHYVILGEHSAHPELAELLQHYTHVPIPPYGELLTVPWGQDKARGGMHTPDSSSASCKAPANHPEYSTIAKRVPGDGQAAESGNEEGPRSPANSKGAETNSSSMQTHHEATPTEMLDAKYQQLMRFHTYAEPHEGAALPVEPIPFYAMGWGSNPSPEANIYAEVATTRQEPPSRGTRGPGSILTPTMFLRRRLSRSLSSQGFHRRQLPATPTAGTMQRAAPRPTPEIPPLQMNSALEFDDPVYSLRMRRTKQATAQENIYEQVPRGHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TTZ5</accession>
    <name>A0A8C2TTZ5_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Junctional adhesion molecule A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Junctional adhesion molecule 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">F11R</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="18">Interacts with the ninth PDZ domain of MPDZ. Interacts with the first PDZ domain of PARD3. The association between PARD3 and PARD6B probably disrupts this interaction. Interacts with ITGAL (via I-domain). Interacts with CD151.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Tight junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the immunoglobulin superfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TTZ5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005023853.1">
        <property type="protein sequence ID" value="ENSCJPP00005017067.1"/>
        <property type="gene ID" value="ENSCJPG00005013969.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159186"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030165">
        <property type="term" value="F:PDZ domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031032">
        <property type="term" value="P:actomyosin structure organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071260">
        <property type="term" value="P:cellular response to mechanical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090557">
        <property type="term" value="P:establishment of endothelial intestinal barrier"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050892">
        <property type="term" value="P:intestinal absorption"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007159">
        <property type="term" value="P:leukocyte cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035683">
        <property type="term" value="P:memory T cell extravasation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051497">
        <property type="term" value="P:negative regulation of stress fiber assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903142">
        <property type="term" value="P:positive regulation of establishment of endothelial barrier"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901731">
        <property type="term" value="P:positive regulation of platelet aggregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035025">
        <property type="term" value="P:positive regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902396">
        <property type="term" value="P:protein localization to bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000810">
        <property type="term" value="P:regulation of bicellular tight junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001817">
        <property type="term" value="P:regulation of cytokine production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090559">
        <property type="term" value="P:regulation of membrane permeability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000342">
        <property type="entry name" value="Junctional adhesion molecule A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042456">
        <property type="entry name" value="F11R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45113">
        <property type="entry name" value="JUNCTIONAL ADHESION MOLECULE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45113:SF1">
        <property type="entry name" value="JUNCTIONAL ADHESION MOLECULE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0965">Cell junction</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="13 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 20" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0796">Tight junction</keyword>
    <keyword evidence="8 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034130061" description="Junctional adhesion molecule A" evidence="20">
        <location>
            <begin position="38"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="243"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="21">
        <location>
            <begin position="37"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="21">
        <location>
            <begin position="138"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00030590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00046718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005017067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="277" mass="30140" checksum="DC6C0E3618A6D699" modified="2022-01-19" version="1">MAAGGTRNGGVWDGGLRNIRVWDALVLSAAALSLVGAQVTQETKEVPENQPVDIPCSAYRSAWRDARIEWKFQKGSSLVLFYYAGQLTEPYKDRVVFSVTSIHFNTVTREDTGKYICEVVGDGSQIAKSEVNLIVQVPPSKPVAHVPSSATIGRTAVLRCSESDGSPPPTFRWYRDGMLVPADPKSSLSFRNSSYTLDSATGELTFNPVSAFDTGDYYCEASNNVGMAQRSDTARMEASEVNVGGIVAAVVVLLMLLGLIAFGIWFAYSRGYFQRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TUR7</accession>
    <name>A0A8C2TUR7_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cilia and flagella associated protein 68</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">CFAP68</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Microtubule inner protein component of sperm flagellar doublet microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Flagellum axoneme</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TUR7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005023761.1">
        <property type="protein sequence ID" value="ENSCJPP00005016980.1"/>
        <property type="gene ID" value="ENSCJPG00005013910.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000002905"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160111">
        <property type="term" value="C:axonemal A tubule inner sheath"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036126">
        <property type="term" value="C:sperm flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030317">
        <property type="term" value="P:flagellated sperm motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009524">
        <property type="entry name" value="CFAP68"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037662">
        <property type="entry name" value="CFAP68/107"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31180">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 107-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31180:SF3">
        <property type="entry name" value="EXPRESSED SEQUENCE EH456644"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06608">
        <property type="entry name" value="CFAP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0282">Flagellum</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005016980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="139" mass="16580" checksum="41E74CFC5985527A" modified="2022-01-19" version="1">MFSFLNGLKHATGYGEVWTETNKFSQFGWRCTTNESDYSPKVLIGNWNEERYDIRNFAQHKPLPSQYSHCFETTYSSDYNKDKDQRRRRFQQEPHWFPCHQPELEPPLFKSTARCSPNSWSKIRLGVNQENRGLRIRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TW01</accession>
    <name>A0A8C2TW01_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="24">Dipeptidase</fullName>
            <ecNumber evidence="24">3.4.13.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">DPEP1</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="21">Independently of its dipeptidase activity, acts as an adhesion receptor for neutrophil recruitment from bloodstream into inflamed lungs and liver.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>L-cystine-bis-glycine + 2 H2O = L-cystine + 2 glycine</text>
            <dbReference type="Rhea" id="RHEA:60520"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35491"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:143812"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a beta-lactam + H2O = a substituted beta-amino acid</text>
            <dbReference type="Rhea" id="RHEA:20401"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35627"/>
            <dbReference type="ChEBI" id="CHEBI:140347"/>
            <dbReference type="EC" id="3.5.2.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 24">
            <text>an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:48940"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="ChEBI" id="CHEBI:77460"/>
            <dbReference type="EC" id="3.4.13.19"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>glycyldehydrophenylalanine + H2O = 2,3-didehydrophenylalanine + glycine</text>
            <dbReference type="Rhea" id="RHEA:62704"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:145925"/>
            <dbReference type="ChEBI" id="CHEBI:145926"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>leukotriene D4 + H2O = leukotriene E4 + glycine</text>
            <dbReference type="Rhea" id="RHEA:48616"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57462"/>
            <dbReference type="ChEBI" id="CHEBI:63166"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 24">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6 24">Homodimer; disulfide-linked.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Apical cell membrane</location>
            <topology evidence="5">Lipid-anchor</topology>
            <topology evidence="5">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="24">Membrane</location>
            <topology evidence="24">Lipid-anchor</topology>
            <topology evidence="24">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="24">Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.13.19" evidence="24"/>
    <dbReference type="RefSeq" id="XP_015729846.1">
        <property type="nucleotide sequence ID" value="XM_015874360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TW01"/>
    <dbReference type="Ensembl" id="ENSCJPT00005025724.1">
        <property type="protein sequence ID" value="ENSCJPP00005018488.1"/>
        <property type="gene ID" value="ENSCJPG00005015058.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107319498"/>
    <dbReference type="KEGG" id="cjo:107319498"/>
    <dbReference type="CTD" id="1800"/>
    <dbReference type="GeneTree" id="ENSGT00940000159615"/>
    <dbReference type="OrthoDB" id="445695at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030054">
        <property type="term" value="C:cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008800">
        <property type="term" value="F:beta-lactamase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072341">
        <property type="term" value="F:modified amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016999">
        <property type="term" value="P:antibiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050667">
        <property type="term" value="P:homocysteine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901749">
        <property type="term" value="P:leukotriene D4 catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030336">
        <property type="term" value="P:negative regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030593">
        <property type="term" value="P:neutrophil chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01301">
        <property type="entry name" value="rDP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000030">
        <property type="entry name" value="Dipeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000180">
        <property type="entry name" value="Dipep_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008257">
        <property type="entry name" value="Pept_M19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443:SF38">
        <property type="entry name" value="DIPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443">
        <property type="entry name" value="MICROSOMAL DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01244">
        <property type="entry name" value="Peptidase_M19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00869">
        <property type="entry name" value="RENAL_DIPEPTIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51365">
        <property type="entry name" value="RENAL_DIPEPTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14 24" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="18 24" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="19" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 24" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="12 24" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="20" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 24" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15 24" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="9 24" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="13 24" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00029402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00048518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="RuleBase" id="RU341113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005018488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="456" mass="49883" checksum="45DFDBD1BE0F9468" modified="2022-01-19" version="1">MAPVLVIDLPRGRAVSSVGALSGTAQQQGRNLIPPPGHRARMLHRIVLLLCLLLPCSGQTFQQEAERIMSTTPVIDGHNDLPWQLLKLFNNQLLLPASNLTQLNSTHTNIPKLNTGHVGGQFWSVYVPCDTQNKDAVKRTLEQIDVVHRMCELYPETFTCVVDSAGIEQAFRDKKVASLIGVEGGHSIDSSLGVLRTFYRLGVRYMTLTHSCNTPWADNWLVDTEQEQPVHHGLTPFGKMVLEEMNRLGMIIDLAHVSVETMKMALNVSKAPVIFSHSSAYSICPHARNVPDDVLQMVASTGSLVMVNFYNQYVTCNNVATLADVADHMDHVKKVAGAEFVGFGGDYDGVTGLPTGLEDVSKYPALVAELLARNWTEQEVRAALADNLLRVFKKVEMVKASLQGTLPLEEPIALEELEGGCRTNYGYTTTTTNTSPALSLPAALVLVLPLLSPLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TW13</accession>
    <name>A0A8C2TW13_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tyrosine-protein phosphatase</fullName>
            <ecNumber evidence="11">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">PTPN3</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
            <location evidence="1 11">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="11"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2TW13"/>
    <dbReference type="Ensembl" id="ENSCJPT00005025384.1">
        <property type="protein sequence ID" value="ENSCJPP00005018230.1"/>
        <property type="gene ID" value="ENSCJPG00005014850.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157888"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008092">
        <property type="term" value="F:cytoskeletal protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001784">
        <property type="term" value="F:phosphotyrosine residue binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017080">
        <property type="term" value="F:sodium channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051045">
        <property type="term" value="P:negative regulation of membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045930">
        <property type="term" value="P:negative regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098902">
        <property type="term" value="P:regulation of membrane depolarization during action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902305">
        <property type="term" value="P:regulation of sodium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13189">
        <property type="entry name" value="FERM_C_PTPN4_PTPN3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06706">
        <property type="entry name" value="PDZ_PTPN3-4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14600">
        <property type="entry name" value="PTPc-N3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000002">
        <property type="entry name" value="Band 4.1-like protein 5 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000045">
        <property type="entry name" value="Tyrosine-protein phosphatase non-receptor type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000104">
        <property type="entry name" value="Tyrosine-protein phosphatase non-receptor type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000023">
        <property type="entry name" value="Tyrosine-protein phosphatase non-receptor type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000003">
        <property type="entry name" value="Tyrosine-protein phosphatase non-receptor type 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019747">
        <property type="entry name" value="FERM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018979">
        <property type="entry name" value="FERM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018980">
        <property type="entry name" value="FERM_PH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041783">
        <property type="entry name" value="PTPN3/4_FERM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012151">
        <property type="entry name" value="Tyr_Pase_non-rcpt_typ-3/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45706">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45706:SF5">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09380">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09379">
        <property type="entry name" value="FERM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000927">
        <property type="entry name" value="Tyr-Ptase_nr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00935">
        <property type="entry name" value="BAND41"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01196">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00660">
        <property type="entry name" value="FERM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00661">
        <property type="entry name" value="FERM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8 11" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FERM" evidence="17">
        <location>
            <begin position="121"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="18">
        <location>
            <begin position="614"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="15">
        <location>
            <begin position="749"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="16">
        <location>
            <begin position="922"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="453"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="509"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="510"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="541"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="12">
        <location>
            <position position="945"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="914"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="945"/>
            <end position="951"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="989"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000927-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000927-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005018230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1016" mass="115267" checksum="A7388D7FA884858C" modified="2022-01-19" version="1">MRVGARPELWLLPARRRQWTDGRAASLPTALPAAPRPTPPSPAQGAGAGGSGPGGAAFRTCSLRCCSSWRRPQRPSAPPGAAGWLRGYSAIVMNSRLRALGGRINNIRASELPKEKTRSEITCNVHFLDGSIQSFKVNKQDTGQILLDMTYSQLGVTEKEYFGLQQNETSVDSPRWLEPNKPIRKQLKGGFPCTFRFRVRFFIPDPNTLQQEQTRHLFFLQLKTDIVEGRLSCPINSAVVLASYAVQSQLGDYDASIHHSGYLSNYNFIPEQNKDFLTKVEALHEQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASSGIAVYRKLICTSFYPWVNILKISFKRKKFFIQQRQKHNESREHIVAFNMLNYRACKNLWKSCVEHHTFFQAKKSLPHEKKVLSHYWTLGSRNPAKSANSQYCRKVIGGMVWNPSMRRSLSVEHLETKSLPSRSPPVTPNWRSPRLRHEIRKARHSSVDNLTNEISYITETEDVFYTYKGSPTSKDSDSEFSQNHSPQRRPSEQESPKNVLGNSPARNSLTHTSPKALTQSPNGVGNISDSYPLEGVDKHFLETYDSVTKSSSTDDSSLYYCDKNEVIDGDLLLVRITPDEDGKFGFNLKGGIDQKMPLVVSRITPGSPADKCIPKLNEGDQIVLINGRDISEHTHDQVVMFIKASRESHTRELALLVRRKVVKQFVEPRSEDEVDSQNIPEALLCTEYADTLEESMEQLRKGLETGTVIHQFEQLYRKKPGLAVTCAKVPQNMDKNRYKDVLPYDATRIILQGDEDYINANYVNMEIPSVGIVNRYIATQGPLPHTCAHFWQVVWDHKLSLIIMLTTLTERGRTKCHQYWPDPPDVMEYGGFRVRCHSEDCTIAYVVREMVITNVETEQQHTVTHLQYVAWPDHGVPDDSMDFLEFVTCMRPKRIANEPVLVHCSAGIGRTGVLVTMETAMCLIERNQPVYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVYKEGLIRPLDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TWA5</accession>
    <name>A0A8C2TWA5_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Diacylglycerol lipase-beta</fullName>
            <ecNumber evidence="16">3.1.1.116</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">PUFA-specific triacylglycerol lipase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Sn1-specific diacylglycerol lipase beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="primary">DAGLB</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="19">Lipase that catalyzes the hydrolysis of arachidonic acid (AA)-esterified diacylglycerols (DAGs) to produce the principal endocannabinoid, 2-arachidonoylglycerol (2-AG) which can be further cleaved by downstream enzymes to release arachidonic acid (AA) for cyclooxygenase (COX)-mediated eicosanoid production. Preferentially hydrolyzes DAGs at the sn-1 position in a calcium-dependent manner and has negligible activity against other lipids including monoacylglycerols and phospholipids. Plays a key role in the regulation of 2-AG and AA pools utilized by COX1/2 to generate lipid mediators of macrophage and microglia inflammatory responses. Also functions as a polyunsaturated fatty acids-specific triacylglycerol lipase in macrophages. Plays an important role to support the metabolic and signaling demands of macrophages.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>1,2,3-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + H2O = 1,2-di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63436"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:77016"/>
            <dbReference type="ChEBI" id="CHEBI:147311"/>
            <dbReference type="ChEBI" id="CHEBI:228170"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>1,2,3-tri-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = 1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63432"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32395"/>
            <dbReference type="ChEBI" id="CHEBI:147308"/>
            <dbReference type="ChEBI" id="CHEBI:228166"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:63433"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33275"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17389"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.116"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:33276"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17855"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:12045"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.116" evidence="16"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2TWA5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005027160.1">
        <property type="protein sequence ID" value="ENSCJPP00005019640.1"/>
        <property type="gene ID" value="ENSCJPG00005015672.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156486"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046340">
        <property type="term" value="P:diacylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022008">
        <property type="term" value="P:neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000064">
        <property type="entry name" value="Sn1-specific diacylglycerol lipase beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052214">
        <property type="entry name" value="DAG_Lipase-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792:SF2">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE-BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 23" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="24">
        <location>
            <begin position="373"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00024531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00026104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00051030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00052740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00056838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00069149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00082880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00083401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005019640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="678" mass="75446" checksum="30E1A7ED44029ED5" modified="2022-01-19" version="1">MPGLVVFGRRWAIGSDDFVLPGTFELFLRLLWWLGIVVLYAVHKGQFSCPGGALLHSYLLVLLALLAAIICTLCALVYVSMQGTISNPGPRKSLPKLLYTRLLLYLPEFIWAVVGAVWVSDSSVRCESTVINVILGTVIASWVIIVFTIIGVLIVFDPLGGKKTFYLTDGLDRNLESSQSGQLLYNVKNTATRVWEKRIRLMCCCIVQDDDHRVAFTSIAELFRAYFSDTDLVPSDIAAGLILLHQEQDKMESCPKEPEEVLCHSPSSLVADDLDIELENAAHYMLFAAAAYGWPYYIYTNPFTALCKLNGDCCRSRPEDCDITGSDRRNFHFGSILRITGLQYRDFIHISFHNKIYEIPFFVALDHKKEAIVVAVRGTLSFEDILTDLSADCEDLTLEDVLENGFVHKGITQAANYIYQKLINDGILNQAFTIAPEYKLVIVGHSLGGGTASVLAIMLRNSFPTLKCYAFSPPGGLLSKALAEYSKRFIISIILGKDLVARLSMPNMEDLKRRIVRIVANCNRPKYQILLRGCWYEVFGGDPDNFPTELDGRNDDALTQPLLAEESLMVHRSPSYNALDGESHLNSPPQYPHLYLPGRIIHIVEESSSRRLCSSDIKYSANWSNETVFSSILISPKMITDHMPDVVLNALNSLVCSIPGGGGGSRVKCCLGLHVQYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TWM3</accession>
    <name>A0A8C2TWM3_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ankyrin repeat domain-containing protein 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ANKRD11</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Chromatin regulator which modulates histone acetylation and gene expression in neural precursor cells. May recruit histone deacetylases (HDACs) to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation. Has a role in proliferation and development of cortical neural precursors. May also regulate bone homeostasis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with the PAS region of the p160 coactivators.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="Ensembl" id="ENSCJPT00005025716.1">
        <property type="protein sequence ID" value="ENSCJPP00005018482.1"/>
        <property type="gene ID" value="ENSCJPG00005015051.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155966"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060325">
        <property type="term" value="P:face morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048705">
        <property type="term" value="P:skeletal system morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000039">
        <property type="entry name" value="Ankyrin repeat domain-containing protein 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042636">
        <property type="entry name" value="ANKRD11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24145">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24145:SF3">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 9" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="167"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="200"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="233"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="128"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="289"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="402"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="517"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="668"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="857"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="891"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1000"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1144"/>
            <end position="1646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1668"/>
            <end position="1694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1701"/>
            <end position="1720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2125"/>
            <end position="2332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2344"/>
            <end position="2400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="21"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="128"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="156"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="309"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="356"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="438"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="452"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="463"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="481"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="517"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="541"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="555"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="591"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="633"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="668"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="685"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="781"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="892"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="953"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1152"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1303"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1330"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1377"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1436"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1484"/>
            <end position="1556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1567"/>
            <end position="1585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1598"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1616"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="2171"/>
            <end position="2181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="2200"/>
            <end position="2215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="2280"/>
            <end position="2296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="2308"/>
            <end position="2321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="2389"/>
            <end position="2400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00059495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00062257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00067265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005018482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="2661" mass="299504" checksum="844CE51CA271A66B" modified="2022-01-19" version="1">MPKGGCSKTPQPEDFSLSNDMVEKQTGKKDKDKVSLTKTPKLDRSDGGKEVKERATKRKLPFTVGTNGDQKDSDTEKQGPERKRIKKEPATRKPGLLFGMGLSGIRAGYPLSERQQVALLMQMTAEESANSPVDTTPKHPSQSTVCQKGTPNSASKTKDKVNKRNERGETRLHRAAIRGDARRIKELIIEGADVNVKDFAGWTALHEACNRGYYDVAKQLLAAGAEVNTKGLDDDTPLHDAANNGHFKVVKLLLHYGGNPHQSNRKGETPLKVANSPTMVNLLLGKTTYPSSEESSTETSEEEDAPSFAPSSSVDGNNTDSEFEKGLKHKPKAQEPPKTITPVKDEYEFDEDDEQDRVPPVDDKHLLKKDYRKETKANSFISIPKMEVKTYTKNNTITPKKAAHRILSDSSDEEEAGVAVGTGEKLRLSTHSILPSSKIREPASTKAPKEKSKVKKKRKKETKSKEVRFGKKNDKFCSSESESENVESEEDDRDSLQSSSCVKDSRLVLKESSLFNSLSASSTSSHGSLGSQKHNANLTEQHSKHWRTDNWKTISSPAWSDVSSLSDSTRTRLTSESDYSSEESSLESLKPVRKKPEHKKKNTSHGTVSEKKNSFHSNVDGAIPKLDKEGKVVKKHKTKHKHKNKDKGQCPIGQDIKIIKTFSFEFEDSKQKPEKGLIVETENPVENKLKALKHEREHCKKEDKLPKGKVEEKDWLFKDETGKSSKEEKSLRKVKDGSKDMSKSFREGLSKSEKEKPAKEKSPKEEKPRIHKEERKKKSKDKQSKSEKKNELKEEKAAKLEKEKSFKEEKEKCKKDKMYREEPGFDEFSNKAQFPESEDTKFSLSDDQQERWFSDLSSDSSFDFKGEDSWDSPVTDFREIKNDSVAKLIIEPVKEEIKDKKKENKTKEKKEYSEKRSEKDSFLKKKERDYVEKSSEKKKDQTERHKAAPGYLPEKDKKRKDSAEDRKESKTKQEEPYRDDFKEYGCEAFFKEKSDAEFSGKALESWERHHSGKDKEKKDASEKEKKEKVKPEKYKEKSKEGDKEKNEKAAPEKIPKDKELEKSFKEKKESKEKYKDLHGKDKERKSSFDQVKEKKEKSFSTDREDFSEKKDEKKGKEKSWYSIADIFTDESEDERDDYSLTGFKVGESVGSEMHRLDSLQEKDEGEKELYSDKHRKYSSDRQHSGEKQKEKESKEKKKDKGTSEGGKEKKEKNSFEKHKEKKDKDSSEKYKDRKDRTSIDSNQEKKNKQKLPEKADKKHASDEKVKNKHKEKLDKEHSKEKKSSKGGEPEKSLLEKLEEEALNDYRDDSNDKISEISSDSFTDRGQDPGLSSLFESSNLSLADASEEKFKDSLPLPCLQDKLKEKERHRHSSSSSKKSHEKEKAKKEKTEKKEKADEFKESSSRKDSSHYEKDFSVDGEAFSTSYGMKAEPDEEPEKSIDYLFSEKKDKNDSERELSKKAEKEKAYGSSAISTTKEKKKRDKHKEKWKEEKEKHRDKHTDGFFKHHKDEPKSALKDKDSPQVTAFKDKSKEENLKFGESKLKEKLKENQEKDKAESIKISNGNEKITLSKDSGKKDARPREKLLGDGDLMMTSFERMLSQKDLEIEERHKRHKERMKQMEKMRHRSGDPKLKDKIKSSEDVRKRSLDLTAKKPLGLDTQLKDKKLKELGPLTPILSPENKAQPTAGADSKDWITGPQLKEILPASPRPDQNRPTGVPTPASVVSCPSYEEVMQTPRTPSCSNEDYTDLMFECADSQHSLPISTMSMNACSPSFFDRYTNVAGALPENPAQTPTRTIPSSNLYRSISVDIRRAPEEEFSVGDKFFRQQSVPATSNYDSPVQHLMEEKVPLPSVPTEKFQCLSPGYYSPDYGVSSPKVEALHCPPAAVSGVSQSPESVFSGLQAKSSPSHRDELLAPSVESALPPDLGMPLDTTEEQQATASIMPPEPSYLPPMEENNFGSAMPEQTNMDWDAPPARNPDTAIPPSLMANAAEHSVGWSMGSELLMKSPQQFAESPKPALCSLEPIHPTPVAFIPTDASYPVSPISYPLSVSEPGLDEVKEDAEEAVPGEMASAEEQAPYMSPTRLDTFFTGCKPLPEEAPEIPAEAPCVPAEPQAEVVSVPENTYLENNSTTPANGEEAVTWPDPFTTTEDELDLGPFSLPELPLQPKDVAEAEVAEAEPAEEGMAAAPEVSAGSTKASMAATAGGEVEEPAAVPAAPIPPTDTEPPAEEQKPDGAVPETTSEATSGTEEKGGEEAEAQMLPAAPSEPAQAEGREAEAPTEGSTSPESAAGRTGSQGPSSQPEAPPAPAEVVEPVQKPVAEAPKPPKIEEIPQRITRNRAQMLANQNKQNAAAAEKEFAPVPAPTTRTKGRGTEEDDSQAQHPRKRRFQRSNQQLQQQINTSTQQTREMIQQTLAAIVDAIKLDDIEPYHSDRSNPYFEYLQIRKKIEEKRKILCYITPQAPQCYAEYVTYTGSYLLDGKPLSKLHIPVIAPPPSLAEPLKELFKQQEAVRGKLRLQHSIEREKLIVSCEQEILRVHCRAARTIANQAVPFSACTMLLDSEVYNMPLENQGDENKSVRDRFNARQFISWLQDVDDKYDRMKTCLLMRQQHEAAALNAVQRMEWQLKVQELDPAGHKSLCVNEVPSFYVPMVDVNDDFVLLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TY18</accession>
    <name>A0A8C2TY18_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">RIB43A domain with coiled-coils 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">RIBC2</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="9">Microtubule inner protein component of sperm flagellar doublet microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Flagellum axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RIB43A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015725978.1">
        <property type="nucleotide sequence ID" value="XM_015870492.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TY18"/>
    <dbReference type="Ensembl" id="ENSCJPT00005027658.1">
        <property type="protein sequence ID" value="ENSCJPP00005020022.1"/>
        <property type="gene ID" value="ENSCJPG00005016177.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107317604"/>
    <dbReference type="KEGG" id="cjo:107317604"/>
    <dbReference type="CTD" id="26150"/>
    <dbReference type="GeneTree" id="ENSGT00390000010825"/>
    <dbReference type="OrthoDB" id="429119at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160111">
        <property type="term" value="C:axonemal A tubule inner sheath"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036126">
        <property type="term" value="C:sperm flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030317">
        <property type="term" value="P:flagellated sperm motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008805">
        <property type="entry name" value="RIB43A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14517:SF10">
        <property type="entry name" value="RIB43A-LIKE WITH COILED-COILS PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14517">
        <property type="entry name" value="RIB43A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05914">
        <property type="entry name" value="RIB43A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0282">Flagellum</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005020022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="380" mass="45500" checksum="0CD9BD64C7C64419" modified="2022-01-19" version="1">MSGLTVQQRELQEAAALERRRQRELQRQGRIFNVRVRTIGVDKDALDAQVKDRKFQEATEKARNEEFANEMKKHDKMLCMLEERQKCNIRNINKAVSNFQKNFQKPETRREFDLYDPQALKKDKPARLSDNDPRCTVSGLQKFMGEDLNYAQRTKFQKEQLREWSLQQQRERKNALADQKYLDDLHDKNRIQLDQKIMEQQRMEERTRRAVCEATKDFNKSQAADLADRKRRDKRQTMKDNMDEISNLLQGDLLSENPDQAISSFGPHRVVTDRWKGMSHDQLMKIRSDQQQQVLEKLRQKEEERHRDAEWDRQNMQAARALLILERHQERQNRERRQALDSINAQLSHEQKSRNIYLKEEEYSNCPTSQYFAQFNTTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TZ12</accession>
    <name>A0A8C2TZ12_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pumilio homolog 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PUM1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasmic granule</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015739053.1">
        <property type="nucleotide sequence ID" value="XM_015883567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TZ12"/>
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        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0810">Translation regulation</keyword>
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    <sequence length="1191" mass="126846" checksum="59EA5A88A8F39E6F" modified="2022-01-19" version="1">MSVACVLKRKAVLWQDSFSPHLKQHAQDTANPNMPVVLTSGTGSQAQPQPAANQALAAGTHSSPVPGSIGVAGRSQDDAMVDYFFQRQHGEQLGGGGSGGGGYNNSKHRWPTGDNIHAEHQVRSMDELNHDFQALALEGRAMGEQLLPGKKFWESDDSSKDGPKGIFLGDQWRDSAWGTSDHSVSQPIMVQRRPGQGFHVNSEVNSVLSPRSESGGLGVSMVEYVLSSSPGDSCLRKGGFGPRDAENDENDKGDKKNKGTFDGDKLGDLKEEGDVMDKTNGLPVQNGIDTDVKDFSRTPGNCQNSASEVDLLGPNQNGSEGLAQLASTNGAKPVEDFSNIESQSVPLDPMEHVGMEPLQFDYSGTQVPVDSAAATVGLFDYNSQQQLFQRPNALAVQQLTAAQQQQYALAAAQQPHIGVFSAGLAPAAFVPNPYIISAAPPGTDPYAAGLAAAATLGPAVVPHQYYGVTPWGVYPASLFQQQAAAAAAATNSANQQTTQQTQQGQQQVLRGGASQRPLTPNQNQQGQQTDPLVAAAAVNSALAFGQGLAAGMPGYPVLAPAAYYDQTGALVVNAGARNGLGAPVRLVAPAPVIISSSAAQAAVAAAAASANGAAGGLAGTTNGPFRPLGTQQPQPQPQQQPTNNLASSSFYGNNSLSSNSQSSSLFSQGSAQPANTSLGFGSSSSLGATLGSALGGFGTAVANSNTGSGSRRDSLTGSSDLYKRTSSSLTPIGHSFYNGLGFSSSPGPVGMPLPSQGPGHSQTPPPSLSSHGSSSSLNLGGLTNGSGRYISAAPGAEAKYRSASSASSLFSPSSTLFPSSRLRYGMSDVMPSGRSRLLEDFRNNRYPNLQLREIAGHIMEFSQDQHGSRFIQLKLERATPAERQLVFNEILQAAYQLMVDVFGNYVIQKFFEFGSLEQKLALAERIRGHVLSLALQMYGCRVIQKALEFIPPDQQNEMVRELDGHVLKCVKDQNGNHVVQKCIECVQPQSLQFIIDAFKGQVFALSTHPYGCRVIQRILEHCLPEQTLPILEELHQHTEQLVQDQYGNYVIQHVLEHGRPEDKSKIVAEIRGNVLVLSQHKFASNVVEKCVTHASRTERAMLIDEVCTMNDGPHSALYTMMKDQYANYVVQKMIDVAEPAQRKIVMHKIRPHIATLRKYTYGKHILAKLEKYYMKNGVDLGPICGPPNGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U0G7</accession>
    <name>A0A8C2U0G7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="27">Tyrosine-protein kinase</fullName>
            <ecNumber evidence="27">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="33" type="primary">TEC</name>
    </gene>
    <organism evidence="33 34">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="33" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="33" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="33" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="27">Belongs to the protein kinase superfamily. Tyr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="27"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2U0G7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005028349.1">
        <property type="protein sequence ID" value="ENSCJPP00005020569.1"/>
        <property type="gene ID" value="ENSCJPG00005016505.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155951"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050853">
        <property type="term" value="P:B cell receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010543">
        <property type="term" value="P:regulation of platelet activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01238">
        <property type="entry name" value="PH_Btk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05114">
        <property type="entry name" value="PTKc_Tec_Rlk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10396">
        <property type="entry name" value="SH2_Tec_Itk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11905">
        <property type="entry name" value="SH3_Tec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000052">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000210">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000151">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000053">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000041">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
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        <property type="entry name" value="PH-like_dom_sf"/>
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        <property type="entry name" value="PH_domain"/>
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        <property type="entry name" value="Prot_kinase_dom"/>
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        <property type="entry name" value="Protein_kinase_ATP_BS"/>
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    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
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        <property type="entry name" value="SH2"/>
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        <property type="entry name" value="SH3-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
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    <dbReference type="InterPro" id="IPR035572">
        <property type="entry name" value="Tec_SH3"/>
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    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
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    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
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    <dbReference type="InterPro" id="IPR001562">
        <property type="entry name" value="Znf_Btk_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
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    <dbReference type="PRINTS" id="PR00402">
        <property type="entry name" value="TECBTKDOMAIN"/>
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    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
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        <property type="entry name" value="BTK"/>
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    </dbReference>
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        <property type="entry name" value="PH"/>
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        <property type="entry name" value="SH2"/>
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    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH2 domain"/>
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    </dbReference>
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    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
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    <dbReference type="PROSITE" id="PS50011">
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    <dbReference type="PROSITE" id="PS51113">
        <property type="entry name" value="ZF_BTK"/>
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    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="20 27" id="KW-0829">Tyrosine-protein kinase</keyword>
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        <location>
            <begin position="33"/>
            <end position="139"/>
        </location>
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            <begin position="209"/>
            <end position="269"/>
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            <begin position="277"/>
            <end position="375"/>
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            <begin position="400"/>
            <end position="650"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
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    <feature type="binding site" evidence="26">
        <location>
            <position position="428"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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            <dbReference type="ARBA" id="ARBA00001947"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
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            <dbReference type="ARBA" id="ARBA00004245"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022553"/>
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    <sequence length="659" mass="76545" checksum="6E7FFC25FB1CA3B5" modified="2022-01-19" version="1">MPELSCVIVNFCEFPGASWTPVVCIFMAEMNMTAILQEILIKRSQQKKRTSPLNYKERLFVLTDSMLTYYEGRAEKKYRKGFVDISRIKCVEVVQNDGIIPCQNKYPFQVVYDANTLYIFAPSAQSRDQWVRNLKEGIKNNSNIMIKYHPKFWTEGIYQCCRQTEKLAPGCEKYNLFENSVVTLPLPVPEKSMRRPPPPVPPAEENDNEEEEVVVAMYDFQPTERHDLRLDKGEEYTVIEKNDIHWWKARDKHGHEGYIPSNYVTGKKSNNLDQYEWYSRNLNRSKAEQLLRNEDKEGGFVVRDSSQPGLYTVSLYTKFGGEGSSGIRHYHIKETVTSPKQYYLAEKHLFNSIPEIIEYHRHNAAGLVTRLRYPVTPKKTTAPTTAGFSYEKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMYEEDFIEEAKVMMKLTHPKLVQLYGVCTQQRPIYIVTEFMEHGCLLNYLRQKRGVLSKDVLLTMCQDVCEGMEYLERNSFIHRDLAARNCLVNDLGVVKVSDFGMTRYVLDDQYTSSSGAKFPVKWCPPEVFNYSRFSSKSDVWSFGVLMWEVFTEGKMPFEKSSNYDVVTMVSQGHRLYRPKLACKQVYEVMMMCWQEKPEGRPTFEDLLHIIIDIAEGEDAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U1I4</accession>
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        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="nucleotide sequence ID" value="XM_015851480.2"/>
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            <end position="211"/>
        </location>
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        <source>
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        </source>
    </evidence>
    <sequence length="227" mass="25552" checksum="2FB21EFEC6A0C188" modified="2022-01-19" version="1">MSGHAEVKVKIPFGNKQLDAIFNVPRKKLRYGVILTHGAGGDMNFPQLVSLSAYLASQGILCLRFTCKGLNIAYRTKAYKTVVEYLKLSDDYKLSGVFLAGRSMGSRAAASVIRQLSQDGDKDDFIQGLICLSYPLHRPKLQSKLRDEDLLFIRCPVLFVSGSADEMCEKRLLEGVASKMKAPKRIHWIDKANHGMAVKGRTEDDVMEEINVQVFSWLRENIEMEHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U4W2</accession>
    <name>A0A8C2U4W2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Gap junction protein</fullName>
        </recommendedName>
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        <name evidence="13" type="primary">GJB5</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">A connexon is composed of a hexamer of connexins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Gap junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 9">Cell membrane</location>
            <topology evidence="2 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the connexin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2U4W2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005029369.1">
        <property type="protein sequence ID" value="ENSCJPP00005021390.1"/>
        <property type="gene ID" value="ENSCJPG00005017108.1"/>
    </dbReference>
    <dbReference type="KEGG" id="cjo:107323840"/>
    <dbReference type="GeneTree" id="ENSGT01030000234513"/>
    <dbReference type="OrthoDB" id="9441654at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005922">
        <property type="term" value="C:connexin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005243">
        <property type="term" value="F:gap junction channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007267">
        <property type="term" value="P:cell-cell signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.80:FF:000001">
        <property type="entry name" value="Gap junction alpha-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.80">
        <property type="entry name" value="Gap junction channel protein cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000500">
        <property type="entry name" value="Connexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019570">
        <property type="entry name" value="Connexin_CCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017990">
        <property type="entry name" value="Connexin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013092">
        <property type="entry name" value="Connexin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038359">
        <property type="entry name" value="Connexin_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11984">
        <property type="entry name" value="CONNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11984:SF29">
        <property type="entry name" value="GAP JUNCTION BETA-5 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00029">
        <property type="entry name" value="Connexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00206">
        <property type="entry name" value="CONNEXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00037">
        <property type="entry name" value="CNX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01089">
        <property type="entry name" value="Connexin_CCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00407">
        <property type="entry name" value="CONNEXINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00408">
        <property type="entry name" value="CONNEXINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0965">Cell junction</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0303">Gap junction</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="185"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Connexin N-terminal" evidence="11">
        <location>
            <begin position="42"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Connexin cysteine-rich" evidence="12">
        <location>
            <begin position="141"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005021390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="291" mass="32696" checksum="2C862501B4D17D09" modified="2022-01-19" version="1">MNWSVFEGLLSGVNKYSTAFGRIWLSLVFIFRLLVYVVAAERVWSDDHKDFDCNTRQPGCTNVCYDHFFPVSHIRLWALQLILVTCPSLLVIMHVAYREAKAQQHRAARGESYRSRFPNPGKKRGGLWWTYLFSLIVKAGVDMVFLYIFYRFYRNYTLPRLVKCQLPPCPNVVDCFISRPTEKTIFTLFMVVTTCICIVLSVVEAAYLIGKRCRERLQASTGESHQDSHDCAEPASTAGQVFHGVGFKDPTASIPSASIPTTSIPVASVPAASIPTTSIPTTLPEQEKTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U592</accession>
    <name>A0A8C2U592_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="23">ADAM metallopeptidase with thrombospondin type 1 motif 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">ADAMTS9</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="16">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015730743.1">
        <property type="nucleotide sequence ID" value="XM_015875257.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005031085.1">
        <property type="protein sequence ID" value="ENSCJPP00005022694.1"/>
        <property type="gene ID" value="ENSCJPG00005018038.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107319904"/>
    <dbReference type="KEGG" id="cjo:107319904"/>
    <dbReference type="CTD" id="56999"/>
    <dbReference type="GeneTree" id="ENSGT00940000156409"/>
    <dbReference type="OrthoDB" id="5948003at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048593">
        <property type="term" value="P:camera-type eye morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061303">
        <property type="term" value="P:cornea development in camera-type eye"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002088">
        <property type="term" value="P:lens development in camera-type eye"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030318">
        <property type="term" value="P:melanocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045636">
        <property type="term" value="P:positive regulation of melanocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009617">
        <property type="term" value="P:response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd04273">
        <property type="entry name" value="ZnMc_ADAMTS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000006">
        <property type="entry name" value="A disintegrin and metalloproteinase with thrombospondin motifs 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.830:FF:000001">
        <property type="entry name" value="A disintegrin and metalloproteinase with thrombospondin motifs 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000001">
        <property type="entry name" value="A disintegrin and metalloproteinase with thrombospondin motifs 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000005">
        <property type="entry name" value="ADAM metallopeptidase with thrombospondin type 1 motif 9"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000010">
        <property type="entry name" value="ADAM metallopeptidase with thrombospondin type 1 motif 9"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000040">
        <property type="entry name" value="ADAM metallopeptidase with thrombospondin type 1 motif 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1620.60:FF:000005">
        <property type="entry name" value="ADAM metallopeptidase with thrombospondin type 1 motif 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.830">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1620.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013273">
        <property type="entry name" value="ADAMTS/ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050439">
        <property type="entry name" value="ADAMTS_ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041645">
        <property type="entry name" value="ADAMTS_CR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045371">
        <property type="entry name" value="ADAMTS_CR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010294">
        <property type="entry name" value="ADAMTS_spacer1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012314">
        <property type="entry name" value="Pept_M12B_GON-ADAMTSs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002870">
        <property type="entry name" value="Peptidase_M12B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723:SF33">
        <property type="entry name" value="A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723">
        <property type="entry name" value="ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17771">
        <property type="entry name" value="ADAMTS_CR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19236">
        <property type="entry name" value="ADAMTS_CR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05986">
        <property type="entry name" value="ADAMTS_spacer1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08685">
        <property type="entry name" value="GON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01562">
        <property type="entry name" value="Pep_M12B_propep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01421">
        <property type="entry name" value="Reprolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19030">
        <property type="entry name" value="TSP1_ADAMTS"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01857">
        <property type="entry name" value="ADAMTSFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51046">
        <property type="entry name" value="GON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="16" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="13 17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 16 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 20" id="KW-0732">Signal</keyword>
    <keyword evidence="10 16 18" id="KW-0862">Zinc</keyword>
    <keyword evidence="12" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034843901" evidence="20">
        <location>
            <begin position="18"/>
            <end position="1929"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="21">
        <location>
            <begin position="283"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="GON" evidence="22">
        <location>
            <begin position="1729"/>
            <end position="1929"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="198"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="active site" evidence="15 18">
        <location>
            <position position="427"/>
        </location>
    </feature>
    <feature type="binding site" description="in inhibited form" evidence="16">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="375"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16 18">
        <location>
            <position position="426"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16 18">
        <location>
            <position position="430"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16 18">
        <location>
            <position position="436"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="486"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="489"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="489"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="358"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="386"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="404"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="442"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="513"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="524"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="531"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="559"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="593"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="597"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="608"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR613273-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR613273-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR613273-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005022694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1929" mass="215859" checksum="8E70E55924D00B40" modified="2022-01-19" version="1">MQLAPLALALTTLFIDGLRTGARRQKLHPRQAKLLEKLSEYEIVTPTRVNEFGEPFPTDVHFRRRRRSTNAAPDAWTAAASSSSSSPKAHYRLSAFGQQFLFNLTANSAFIAPLFTVSILGEPAAEQRNLYAETADTDVKHCFYRGHVNARPRHTAVISLCSGMLGTFKSDDGDYFVEPLLSLEQEYEEEHNKPHLVYRHRTPPTNSSGDRQTCDTPDHEHSHKKNKRKHWRKQWVESSLLSDTEMLKHSLEVNPFSADSNETGNVSEKKSHRRTKRFLSYPRFVEVMVVADSRMVAYHGANLQHYVLTLMSIVASIYKDPSIGNLINIVIVKLVVIHNEQDGPAISYNAQTTLKNFCQWQQSQNHPEGSHLQHDTAVLVTRQDICRAHDKCDTLGLAELGTVCDPYRSCSISEDNGLSTAFTIAHELGHVFNMPHDDNHKCKEDGIKHQYHVMAPTLNYHTSPWTWSKCSQKYITEFLDTGYGECLLDEPSSRTYALPQQLPGLIYDVNKQCELIFGPGSQVCPYMQMQCRRLWCINIDGAHKGCRTQHTPWADGTECEPGKHCRFGMCVPKEREAPVVDGAWGTWSPFGTCSRTCGGGIKTAIRECNRPEPKNGGKYCVGRRMKFKSCNTEPCSKLKKDFRDEQCADFDGKHFNINGLPTNVRWVPKYSGILMKDRCKLFCRVAGNTAYYQLRDRVIDGTPCGPDTNDICVQGLCRQAGCDHVLNSKARRDKCGVCGGDNSSCKTVAGTFNTVHYGYNVVVRIPAGATNIDVRQHSYSGKPEDDNYLALSNSQGDFILNGDFVVSMFKREIKVGNAVIEYSGSDNAIERINSTDRIEQEITLQVLSVGNLYNPDVRYTFNIPIEDKPQQFYWNAYGPWQPCSKLCQGERKRKPVCTRESDQLTVSDQRCDRIPQPDPIMEPCGTECELRWHVARRSECTAQCGLGYRMLEIYCSKYNRLEGKTEKVDDRFCSSQTKPSAREKCTGDCNVGGWRYSAWTECSKSCGGGTRRRRAMCVSTYNDVLDDSKCSQQEKLTVQRCSDFLCPQWKTGDWSECLVTCGKGHKHRQTWCQFGEDRLNDRFCDPETKPESVQTCQQQECAAWQVGPWGQCTVTCGQGYQMRAVKCVVGTYMSVVDDNECNAATKPTDTQDCEIAACPPHPNSPEAKRSISGVHRTQWRFGSWTPCSATCGKGTRMRYVSCRDEQGSVADESACFHLPKPSATEVCTVTPCGQWKALEWSSCSVTCGQGKATRQVICIDYSDQLVDRSECDPDDLPATEQDCSMSPCHPNSHDYGRPIHPFLYPDHRLKLHPGGSPNRNRAHIPGGNQWRIGPWGACSSTCAGGFQRRVVVCQDENGYTANNCDEKTKPMEQRSCESGPCPQWAYGNWGECTKPCGAGTRTRLVVCQRPNGERFTDLSCEILDKPPDREQCNVQDCPRDAAWSAGPWSSCSVSCGRGQRHRTVYCLTKEGRHVEEDYCKHLVKPNVQKKCRGGRCPKWKSGDWGQCSVSCGRGVQRRAVQCHGGGPTAECDPASQPASQRDCQLPECPTHRWAAGEWQACMKTCGEAARYRKVFCVDENKQVQSSDHCDASKRPPEMESCGLPPCEYIWITGEWSECSVTCGKGYRQRLVSCSEIYTGKDHYEYGYQNTVSCPGTQPPNIQPCYLGECPVSASWRVSNWGSCSVTCGVGVMHRSVQCLTNDDQLSSLCRADLKPEERRTCHNVHDCELPRSCNDVKNLKGVTEDGEYFLKVKGKTLKVYCSGMQTDSPKEYVTLVNGDAENFSEVYGYRLHNPTECPYNGSRREDCQCRKDYTAAGFSTFSKVRLDLNTMQIITTDLQFARTHDGRPVPYATAGDCYSAAKCPQGRFSIDLYGTGLSLTATAKWLSQGNYAVSEIQKSPDGTKVVGRCGGYCGKCTPSSGTGLDVQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U5P4</accession>
    <name>A0A8C2U5P4_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Debranching RNA lariats 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">DBR1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the lariat debranching enzyme family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015726480.1">
        <property type="nucleotide sequence ID" value="XM_015870994.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U5P4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005032372.1">
        <property type="protein sequence ID" value="ENSCJPP00005023646.1"/>
        <property type="gene ID" value="ENSCJPG00005018720.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107317854"/>
    <dbReference type="KEGG" id="cjo:107317854"/>
    <dbReference type="CTD" id="51163"/>
    <dbReference type="GeneTree" id="ENSGT00510000047481"/>
    <dbReference type="OrthoDB" id="407609at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008419">
        <property type="term" value="F:RNA lariat debranching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000292">
        <property type="term" value="P:RNA fragment catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00844">
        <property type="entry name" value="MPP_Dbr1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000035">
        <property type="entry name" value="Lariat debranching enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007708">
        <property type="entry name" value="DBR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041816">
        <property type="entry name" value="Dbr1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12849:SF0">
        <property type="entry name" value="LARIAT DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12849">
        <property type="entry name" value="RNA LARIAT DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05011">
        <property type="entry name" value="DBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01124">
        <property type="entry name" value="DBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lariat debranching enzyme C-terminal" evidence="14">
        <location>
            <begin position="235"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="388"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="414"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="430"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="484"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005023646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="536" mass="60848" checksum="AC4F8875C6E1DD7C" modified="2022-01-19" version="1">MKVAVAGCCHGALDKMYETLELLQRRHNVRPDLLLCCGDFQAVRNEADLRCMAVPAKYRHMQTFYRYYSGEKKAPVLTVFIGGNHEASNHLQELPYGGWVAPNIYYLGYAGVVRFRGVRIGGISGIFKSHDYRKGHFECPPYNQQTIRSAYHVRNIEVFKLKQLKHPMDIFMSHDWPRSIYHYGNKKQLLKMKSFFRQEVESNTLGSPAASELLQHLKPNYWFSAHLHVKFAAFMQHETKSKEELPKATKFLALDKCLPHRDFLQIIDIEHDPTAGDSLEYDAEWIAVLKATNSLISVTQSSWNMPENNGLHAKWDYSVTEEAIKEVLEELNHNLKIPCNFTLTAACYDPSKPQKNMEPVHTINPQTTEFCAQFGLTDINNRIQQVKEEGSVRGEYEEEEEEMDSSGSAEEPSEYNTDNSGLSSINPDEIMLDDEGGDEDLSTCSVDPSPDHPPEFSASFSDIRIMPDSMAVSSDDAMDSTNEELEKSGVNKQVEEKSLNERPLKRVSGGENGNSGIKIKRRNQAIYAAEDEEETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U5Y0</accession>
    <name>A0A8C2U5Y0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DCN1-like protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Defective in cullin neddylation protein 1-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">DCUN1D3</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015732960.1">
        <property type="nucleotide sequence ID" value="XM_015877474.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015732961.1">
        <property type="nucleotide sequence ID" value="XM_015877475.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015732962.1">
        <property type="nucleotide sequence ID" value="XM_015877476.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U5Y0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005032470.1">
        <property type="protein sequence ID" value="ENSCJPP00005023742.1"/>
        <property type="gene ID" value="ENSCJPG00005018775.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107321008"/>
    <dbReference type="KEGG" id="cjo:107321008"/>
    <dbReference type="CTD" id="123879"/>
    <dbReference type="GeneTree" id="ENSGT00940000154944"/>
    <dbReference type="OrthoDB" id="27198at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032182">
        <property type="term" value="F:ubiquitin-like protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030308">
        <property type="term" value="P:negative regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000134">
        <property type="term" value="P:negative regulation of G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000435">
        <property type="term" value="P:negative regulation of protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000436">
        <property type="term" value="P:positive regulation of protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010332">
        <property type="term" value="P:response to gamma radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010225">
        <property type="term" value="P:response to UV-C"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000126">
        <property type="entry name" value="DCN1-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.200:FF:000003">
        <property type="entry name" value="DCN1-like protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.200">
        <property type="entry name" value="Cullin, PONY binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014764">
        <property type="entry name" value="DCN-prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042460">
        <property type="entry name" value="DCN1-like_PONY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005176">
        <property type="entry name" value="PONY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281:SF31">
        <property type="entry name" value="DCN1-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281">
        <property type="entry name" value="RP42 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03556">
        <property type="entry name" value="Cullin_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51229">
        <property type="entry name" value="DCUN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0519">Myristate</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DCUN1" evidence="12">
        <location>
            <begin position="86"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005023742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="304" mass="34366" checksum="DF25440B013E29B7" modified="2022-01-19" version="1">MGQCVTKCKNPSSTLGSKNGERETGSKSHSKRSAVHKDDHTSACGKSSGDILVNGTKKADAAVESGPPSVFSGDTKKDSVSSAEESSLQKIGELFRRYKDEREDAILEEGMERFCSDLCVDPTEFKVLVLAWKFQAATMCKFTRKEFFEGCKAINADSIDGICARFPSLLHEAKQEDKFKDLYRFTFQFGLDSEEGQRSLHREIAIALWKLVFTQNKPPILDQWLHFLVENPSGIKGISRDTWNMFLNFTQVIGPDLSNYSEDEAWPSLFDTFVEWEMERRKKEEETKCIMSSDTGGLCREEQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U6G8</accession>
    <name>A0A8C2U6G8_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">WD repeat domain 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">WDR1</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the WD repeat AIP1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2U6G8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005031836.1">
        <property type="protein sequence ID" value="ENSCJPP00005023198.1"/>
        <property type="gene ID" value="ENSCJPG00005018439.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000009416"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030043">
        <property type="term" value="P:actin filament fragmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043297">
        <property type="term" value="P:apical junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030865">
        <property type="term" value="P:cortical cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042247">
        <property type="term" value="P:establishment of planar polarity of follicular epithelium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040011">
        <property type="term" value="P:locomotion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045199">
        <property type="term" value="P:maintenance of epithelial cell apical/basal polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002446">
        <property type="term" value="P:neutrophil mediated immunity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990266">
        <property type="term" value="P:neutrophil migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030220">
        <property type="term" value="P:platelet formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030836">
        <property type="term" value="P:positive regulation of actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060307">
        <property type="term" value="P:regulation of ventricular cardiac muscle cell membrane repolarization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045214">
        <property type="term" value="P:sarcomere organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000097">
        <property type="entry name" value="WD repeat domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000203">
        <property type="entry name" value="WD repeat domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011045">
        <property type="entry name" value="N2O_reductase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19856:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19856">
        <property type="entry name" value="WD-REPEATCONTAINING PROTEIN WDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50974">
        <property type="entry name" value="Nitrous oxide reductase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50960">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="243"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="374"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="419"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="505"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="717"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005023198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="796" mass="85339" checksum="0CC49C591E2200C4" modified="2022-01-19" version="1">MGGSGWTCGGFSSGRLGRLTAHSSQLTCPSPSLPRLHGRSCACVAAREESSHAQTFRRHPPRGRPEPPCSARCAHRCGSSAAPCRGGAGSCGRLSTHSLIHAALPGPAEPTAFPGVGAACGAGGERRGASRVDYIWSKAGESGGPRGRFLLRAAGRRGAEAVGGEQSAAAVVCPPASASAAPQRELGTRMPYEIKKVFASLPQVERGVSKIIGGDPKGNNFLYTNGKCVVIRNIDNPAIADIYTEHAHQVVVAKYAPSGFYIASGDVSGKLRIWDTTQKEHLLKYEYQPFAGKIKDLAWTEDSKRIAVVGEGREKFGAVFLWDSGSSVGEITGHNKVINSVDIKQTRPYRLATGSDDNCAAFFEGPPFKFKFTLSDHTRFVNCVRFSPDGNRFATASADGQIFIYDGKTGEKVCALGGGKAHDGGIYAISWSPDSSQLLSASGDKTAKIWDVGANSVVSTFNMGSNVLDQQLGCLWQKDHLLSLSLSGYINYLDKNNPDKPLRVIKGHSKSIQCLTVHKNGGKSYIYSGSNDGHINYWDSDTGENDGFSGKGHTNQVSRMAVDEMDQLVTCSMDDTVRYTNLSKRDYSGQDAVKMDVQPKCLAVGPGGYTVVLCIGQIVLMKDKKKCFAIDDLGYEPEAVAVHPGGTSVAVGGTDGNVRLYSIQGNSLKSDDKTLEAKGPVTDLAYSHDGAFLAVCDANKVVTVFSVPDGYAEHNVFYGHHAKVVCIAWSPDNEHFASGGMDMMVYVWTVSDPETRVKIPDAHRLHHVSGLAWLDEHTLVTTSHDASVKEWSISYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U7G4</accession>
    <name>A0A8C2U7G4_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein lin-52 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LIN52</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lin-52 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2U7G4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005033216.1">
        <property type="protein sequence ID" value="ENSCJPP00005024354.1"/>
        <property type="gene ID" value="ENSCJPG00005019214.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000008402"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070176">
        <property type="term" value="C:DRM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018737">
        <property type="entry name" value="DREAM_LIN52"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31489">
        <property type="entry name" value="LIN52 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31489:SF2">
        <property type="entry name" value="PROTEIN LIN-52 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10044">
        <property type="entry name" value="LIN52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005024354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="112" mass="12467" checksum="06D666CCA9BF6272" modified="2022-01-19" version="1">MSAPGTRADLEASLLSFEKLDRASPDLWPEQLPGVAEFAASFKSPITSSPPKWMAELENDDIDMLKELGSLTTANLMEKVRGLQNLAYQLGLDESREMTRGKFLNILEKPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U7W2</accession>
    <name>A0A8C2U7W2_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">F-box and leucine rich repeat protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">FBXL3</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015707111.1">
        <property type="nucleotide sequence ID" value="XM_015851625.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U7W2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005033851.1">
        <property type="protein sequence ID" value="ENSCJPP00005024863.1"/>
        <property type="gene ID" value="ENSCJPG00005019556.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107308052"/>
    <dbReference type="KEGG" id="cjo:107308052"/>
    <dbReference type="CTD" id="26224"/>
    <dbReference type="GeneTree" id="ENSGT00940000159491"/>
    <dbReference type="OrthoDB" id="9974792at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042752">
        <property type="term" value="P:regulation of circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048511">
        <property type="term" value="P:rhythmic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22178">
        <property type="entry name" value="F-box_FBXL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23957">
        <property type="entry name" value="FBXL3_LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.50:FF:000005">
        <property type="entry name" value="F-box/LRR-repeat protein 3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000010">
        <property type="entry name" value="F-box/LRR-repeat protein 3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10224">
        <property type="entry name" value="ES1 PROTEIN HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10224:SF19">
        <property type="entry name" value="F-BOX AND LEUCINE-RICH REPEAT PROTEIN 21, PSEUDOGENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="11">
        <location>
            <begin position="44"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005024863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="433" mass="49075" checksum="CF76F13F870D588F" modified="2022-01-19" version="1">MKRGRKTNEANNSSSEETAGKESKRHKSVDDKAAVVQSPDWGNLLQDIILQVFQYLPLLDRAHASQVCRSWNQVFHMPDLWRCFEFELNQPATSYLRATHPELIKQIIKRHSNHLQYVSFKVDSSKESAEAACDILSQLVNCSLKTLGLISTARPSFMDLPKAHFASALTVVFVNSKSLSSIKIDDTPVDDPSLKVLVANNSDTLKLLKMSSCPHVSPAGILCVADQCHGLRELALNYHLLSDELLLALSSEKHVRLEHLRIDVVSENPGQVEFHTIKKQSWDAFVKHSPKVNIVMYFFLYEDEFDPFFREETPVTHLYFGRSVSKDVLGRVGMTCPRLVELVVCANGLRPLDEELIRIAERCKYLSAVGLGECEVSCSAFVEFVKMCGGRLSQLSIMEEVLIPDQKYSLEQIHWEVSKHLGRVWFPDMMPTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U8P9</accession>
    <name>A0A8C2U8P9_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Keratin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC107324999</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the avian keratin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015740921.1">
        <property type="nucleotide sequence ID" value="XM_015885435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U8P9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005032828.1">
        <property type="protein sequence ID" value="ENSCJPP00005024037.1"/>
        <property type="gene ID" value="ENSCJPG00005018995.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107324999"/>
    <dbReference type="KEGG" id="cjo:107324999"/>
    <dbReference type="GeneTree" id="ENSGT01030000234722"/>
    <dbReference type="OrthoDB" id="9117292at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005882">
        <property type="term" value="C:intermediate filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003461">
        <property type="entry name" value="Keratin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31203">
        <property type="entry name" value="BETA-KERATIN-RELATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31203:SF1">
        <property type="entry name" value="BETA-KERATIN-RELATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02422">
        <property type="entry name" value="Keratin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0416">Keratin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="92"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005024037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="104" mass="10819" checksum="4CD2EC4923C3B66A" modified="2022-01-19" version="1">MSCYDQCLPRLPCQPCGPTPLANSCNEPCFRQCQDSNVFIQPSPVVVTLPGPILSSFPQNTAVGSSTSAAVGSILSSEGVPISSGGFGLSGLGSRYSSRRFFPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U8X9</accession>
    <name>A0A8C2U8X9_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin recognition factor in ER-associated degradation protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">UFD1</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-derived structures. Acts as a negative regulator of type I interferon production via the complex formed with VCP and NPLOC4, which binds to RIGI and recruits RNF125 to promote ubiquitination and degradation of RIGI.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein degradation; proteasomal ubiquitin-dependent pathway.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UFD1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015733020.1">
        <property type="nucleotide sequence ID" value="XM_015877534.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U8X9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005032931.1">
        <property type="protein sequence ID" value="ENSCJPP00005024133.1"/>
        <property type="gene ID" value="ENSCJPG00005019054.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107321039"/>
    <dbReference type="KEGG" id="cjo:107321039"/>
    <dbReference type="CTD" id="7353"/>
    <dbReference type="GeneTree" id="ENSGT00390000002408"/>
    <dbReference type="OrthoDB" id="422728at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036501">
        <property type="term" value="C:UFD1-NPL4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034098">
        <property type="term" value="C:VCP-NPL4-UFD1 AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036435">
        <property type="term" value="F:K48-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071218">
        <property type="term" value="P:cellular response to misfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0039536">
        <property type="term" value="P:negative regulation of RIG-I signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032480">
        <property type="term" value="P:negative regulation of type I interferon production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.50:FF:000001">
        <property type="entry name" value="Ubiquitin fusion degradation protein 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.330.10:FF:000002">
        <property type="entry name" value="ubiquitin fusion degradation protein 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.50">
        <property type="entry name" value="Ubiquitin fusion degradation protein UFD1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004854">
        <property type="entry name" value="Ufd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042299">
        <property type="entry name" value="Ufd1-like_Nn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055417">
        <property type="entry name" value="UFD1_N1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055418">
        <property type="entry name" value="UFD1_N2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555">
        <property type="entry name" value="UBIQUITIN FUSION DEGRADATON PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555:SF13">
        <property type="entry name" value="UBIQUITIN RECOGNITION FACTOR IN ER-ASSOCIATED DEGRADATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03152">
        <property type="entry name" value="UFD1_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24842">
        <property type="entry name" value="UFD1_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin fusion degradation protein UFD1 N-terminal subdomain 1" evidence="7">
        <location>
            <begin position="56"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin fusion degradation protein UFD1 N-terminal subdomain 2" evidence="8">
        <location>
            <begin position="157"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="268"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00058252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00060618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00072593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005024133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="344" mass="38811" checksum="35CA5AE4ED82AD66" modified="2022-01-19" version="1">MAAGGRSRGRISGVRQRSGRVRRQHRERLRELRRAANMFSFNMFDHPIPRVFQNRFSTQYRCFSVSMLAGPNDRSDVEKGGKIIMPPSALDQLSRLNITYPMLFKLTNKNSDRMTHCGVLEFVADEGICYLPHWMMQNLLLEEGGLVQVESVNLQVATYSKFQPQSPDFLDITNPKAVLENALRNFACLTTGDVIAINYNEKIYELRVMETKPDKAVSIIECDMNVDFDAPLGYKEPERSAQHEEATDVEADHSGYVSDVGFRAFSGSGNRLDGKKKGVEPSPSPIKPGDIRRGIPNYDFKIGRITFIRNSRPLVKKVEEDDAGGRFIAFSGEGQSLRKKGRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UB58</accession>
    <name>A0A8C2UB58_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Armadillo like helical domain containing 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ARMH3</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2UB58"/>
    <dbReference type="Ensembl" id="ENSCJPT00005034217.1">
        <property type="protein sequence ID" value="ENSCJPP00005025129.1"/>
        <property type="gene ID" value="ENSCJPG00005019742.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000002554"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903358">
        <property type="term" value="P:regulation of Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039868">
        <property type="entry name" value="ARMD3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013636">
        <property type="entry name" value="ARMH3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13608">
        <property type="entry name" value="ARMADILLO-LIKE HELICAL DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13608:SF3">
        <property type="entry name" value="ARMADILLO-LIKE HELICAL DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08427">
        <property type="entry name" value="ARMH3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01158">
        <property type="entry name" value="DUF1741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Armadillo-like helical" evidence="5">
        <location>
            <begin position="426"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005025129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="680" mass="77768" checksum="397F0BA89C402829" modified="2022-01-19" version="1">MAQTEKKGGLLRKSSASKKPLKEKVVLMYDEIFTTEDPSKSNPRFWEELFLMKVNLEYLEGKLEALDGEELMKIKDNINCLFQHCIQALGEEHPIRVVNALQTLCALIRGVHQKNKSTSGFDIINMLVGFDKAELCMKNLMESLDSLLCAEGSESLKSLCLKLLLCLVTVTDNISQNTILEYVMINSIFEAILQILSSPLSRREHGYDAVVLLALLVNYRKYESVNPYIVKLSIVDDEATFILISLFRQYKDKEEEHQSGFFSALTNMVGSMFIADADEKISVQTNEAILLALYEAVHLNRNFITVLAQSHPEMGLMTTPASPIPTTPVTPLGTTPPSSDVISSAELPLDADVQTSNLLITFLKYSSIVMQDTKDEHRLHSGKLCLIILTCIAEDQYANAFLHDDNMNFRVNLHRMPMRHRKKAADKNLPCRPLVCAVLDLMVEFIVTHMMKEFPMDLYIRCIQIVHKLLCYQKKCRVRLHYTWRELWSALINLLKFLMSNETVLLAKHNIFTLALMVVNLFNMFITYGDTFLPTPSSYDELYYEIIRMHQNFDNLYSMVLRISTNAGQWKEPASKVTHALVNIRAIINHFNPKIESYAAVNHISQLSEDQVLEVVRSNYDTLTLKLQDGLDQYERYSEQHKEAAFFKELVRSISINVRKNLAFNTLSQELLLKEFSTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UBF8</accession>
    <name>A0A8C2UBF8_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Coiled-coil domain containing 92</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">CCDC92</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UBF8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005034382.1">
        <property type="protein sequence ID" value="ENSCJPP00005025257.1"/>
        <property type="gene ID" value="ENSCJPG00005019843.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00430000031027"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040370">
        <property type="entry name" value="CCDC74A/CCDC74B/CCDC92"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039496">
        <property type="entry name" value="CCDC92/74_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14882">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING 74A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14882:SF4">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14916">
        <property type="entry name" value="CCDC92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCDC92/74 N-terminal" evidence="4">
        <location>
            <begin position="15"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="154"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="67"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="157"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005025257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="318" mass="35771" checksum="0ABA4A28025C47E6" modified="2022-01-19" version="1">PVSPHFSGMATSNLENQLHSAQKNLLFLQREHASTLKGLHAEIRRLQQHCTDLTYELTVKSSDFSRSDELKRKCEDLEAQLKAKEAENNELLKELEQKNAMIMVLENTIKEREKKYLEELKMKSHKLNMLSSELEQRASTIAYLTSQLHATKKKLMSSSGTSEGTPSGSPVLSSYKPAPPKDKLPETPRRRMKKSLSTPLNPEFEEAYRIGSDSRKLLLREHVDAMPDPTPFLLARETSEVHLIKERPLVIPPIASDRASGESQSPAREKPHKAHVGVAHRIHHVAPSQPQPEVETLAVDQVNGSKVVRKHSGTDRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UBI1</accession>
    <name>A0A8C2UBI1_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UBI1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005035586.1">
        <property type="protein sequence ID" value="ENSCJPP00005026270.1"/>
        <property type="gene ID" value="ENSCJPG00005020450.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000235139"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034189666" evidence="2">
        <location>
            <begin position="21"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005026270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="107" mass="12079" checksum="B141C861200CF4EF" modified="2022-01-19" version="1">MYRKSCKLLFVGMLYRQVAAEDLQKHTAELLRRDIVQQGVHHGAEVEEDVSNGKEDDVRPEVGDGPVLLWFSSSHDPSNLVWHPAYCQGCNNQSYEQKEGGGGNMKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UBJ5</accession>
    <name>A0A8C2UBJ5_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CFAP97 domain containing 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CFAP97D1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CFAP97 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2UBJ5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005033436.1">
        <property type="protein sequence ID" value="ENSCJPP00005024550.1"/>
        <property type="gene ID" value="ENSCJPG00005019338.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000018148"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007288">
        <property type="term" value="P:sperm axoneme assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038792">
        <property type="entry name" value="CFAP97D1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029488">
        <property type="entry name" value="Hmw/CFAP97"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33768">
        <property type="entry name" value="MIP11318P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33768:SF5">
        <property type="entry name" value="SPERM AXONEMAL MAINTENANCE PROTEIN CFAP97D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13879">
        <property type="entry name" value="Hmw_CFAP97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005024550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="144" mass="16721" checksum="F34EC3CEE857AC92" modified="2022-01-19" version="1">EIVTIKCLQLGFYICLSLSCNGSHLTSAAIKHHCKLSLAQKDQKRISQIERDNERLMENLAAIQRGPASVDCWNIDFQRSNKKNKKIMAITVENQALLKRITDCKPTYDRKKFEIEWQACKYLQGVLRFLLIQETLGHFFSFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UC44</accession>
    <name>A0A8C2UC44_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Low-density lipoprotein receptor-related protein 1B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Low-density lipoprotein receptor-related protein-deleted in tumor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">LRP1B</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Potential cell surface proteins that bind and internalize ligands in the process of receptor-mediated endocytosis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Binds LRPAP1, PLAU, PLAT and SERPINE1; binding is followed by internalization and degradation of the ligands.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LDLR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSCJPT00005035672.1">
        <property type="protein sequence ID" value="ENSCJPP00005026336.1"/>
        <property type="gene ID" value="ENSCJPG00005020489.1"/>
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    <dbReference type="GeneTree" id="ENSGT00940000157521"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
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        <property type="term" value="F:calcium ion binding"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0042562">
        <property type="term" value="F:hormone binding"/>
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        <property type="term" value="P:receptor-mediated endocytosis"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="LDLa"/>
        <property type="match status" value="19"/>
    </dbReference>
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        <property type="entry name" value="LDL receptor related protein 1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="LDL receptor related protein 1B"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Low-density lipoprotein receptor isoform 1"/>
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        <property type="entry name" value="Low-density lipoprotein receptor-related protein 1"/>
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        <property type="entry name" value="Low-density lipoprotein receptor-related protein 1"/>
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        <property type="entry name" value="Low-density lipoprotein receptor-related protein 1"/>
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        <property type="entry name" value="prolow-density lipoprotein receptor-related protein 1"/>
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    <dbReference type="FunFam" id="2.120.10.30:FF:000009">
        <property type="entry name" value="Putative low-density lipoprotein receptor-related protein 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000065">
        <property type="entry name" value="Transmembrane protease serine 7"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Laminin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="22"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
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    </dbReference>
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        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026823">
        <property type="entry name" value="cEGF"/>
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    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
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        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
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        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
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        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
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        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
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        <property type="entry name" value="LDLR-related"/>
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    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
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    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
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    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
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        <property type="entry name" value="LRP1-like_beta_prop"/>
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    <dbReference type="PANTHER" id="PTHR22722:SF5">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 1B"/>
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    <dbReference type="PANTHER" id="PTHR22722">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="DUF5050"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FXa_inhibition"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="21"/>
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        <property type="entry name" value="Ldl_recept_b"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="16"/>
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    <dbReference type="SMART" id="SM00179">
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        <property type="match status" value="4"/>
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    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="22"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="34"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="22"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
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    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="22"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51120">
        <property type="entry name" value="LDLRB"/>
        <property type="match status" value="18"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="11 18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 20" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034389077" description="Low-density lipoprotein receptor-related protein 1B" evidence="20">
        <location>
            <begin position="22"/>
            <end position="3385"/>
        </location>
    </feature>
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        <location>
            <begin position="77"/>
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    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="19">
        <location>
            <begin position="237"/>
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        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="19">
        <location>
            <begin position="281"/>
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    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="19">
        <location>
            <begin position="467"/>
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    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="19">
        <location>
            <begin position="510"/>
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    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="19">
        <location>
            <begin position="556"/>
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    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="19">
        <location>
            <begin position="606"/>
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    <feature type="repeat" description="LDL-receptor class B" evidence="19">
        <location>
            <begin position="1199"/>
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    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="19">
        <location>
            <begin position="1246"/>
            <end position="1288"/>
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    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="19">
        <location>
            <begin position="1289"/>
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    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="19">
        <location>
            <begin position="1517"/>
            <end position="1559"/>
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    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="19">
        <location>
            <begin position="1604"/>
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    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="19">
        <location>
            <begin position="1821"/>
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    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="19">
        <location>
            <begin position="1864"/>
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    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="19">
        <location>
            <begin position="1907"/>
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    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="19">
        <location>
            <begin position="1951"/>
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    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="19">
        <location>
            <begin position="2229"/>
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        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="21">
        <location>
            <begin position="2850"/>
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        </location>
    </feature>
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        <location>
            <begin position="2998"/>
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    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="19">
        <location>
            <begin position="3041"/>
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    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="744"/>
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    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="751"/>
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    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="785"/>
            <end position="797"/>
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    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="792"/>
            <end position="810"/>
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    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="826"/>
            <end position="838"/>
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    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="833"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="874"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="886"/>
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="905"/>
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="912"/>
            <end position="930"/>
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    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="972"/>
            <end position="987"/>
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    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="1015"/>
            <end position="1030"/>
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    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="2417"/>
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    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="2451"/>
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    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="2458"/>
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    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="2470"/>
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    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="2490"/>
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    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
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    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="2509"/>
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    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
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    <feature type="disulfide bond" evidence="18">
        <location>
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    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
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    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="2600"/>
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    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="2619"/>
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    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="2626"/>
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    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="2704"/>
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
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    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="2744"/>
            <end position="2756"/>
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    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="2790"/>
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    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="2797"/>
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    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="2809"/>
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    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="3216"/>
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    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="3223"/>
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="3256"/>
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    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="3263"/>
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    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
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    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="3315"/>
            <end position="3330"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="3355"/>
            <end position="3370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00059602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00063344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00074267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00080211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS01186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005026336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="3385" mass="379646" checksum="1ED30B7D167F0E81" modified="2022-01-19" version="1">MFSNNLLSIILFTELLPRCQQMNCQYKCAITRNGTKCYCGDGYETSSDGRSCTDLNECNSYGSCSQMCMNTDGSYTCSCVEGYVLQPDNKSCKAKNEPADRPPLLLIANSETIEVLHLNGSKVSARTPLKGSSVLTVDYSYREDTICWIESRDLASQLKCTKMTRAGKLTDEWIINVVQYLNNVQQIAIDWITGNFYFLDHVSDRIFVCNQNGTVCITLIELDLSNPKAIAVDPTSGKLFFTDYGNVAKVERCDMDGMNRTWIVDSKIEQPTALALDLINKYVYWIDIYLDNVEVVDYEGRKRHTVIKGRQVRHLCGLAVFENYLYAVNSDNFSIWQINRYNGTDVRALTRLENAKEIRVYQKRTQTSVRSHACEVDPYGMPGGCSHICLLSNSYKTRTCRCRTGFILGSDGRSCKRPKNELFLFYGKGRPGIIRGMDLNTKVSDEYMIPIENLVNPRALDFHAETNYIYFADTTSFLIGRQKIDGTERETILKDDLDNVEGIAVDWIGNNLYWTNDGHRKTIAVARLEKAAQSRKTLLEGDMSHPRGIVVDPVNGWMYWTDWEEDEIDDSVGRIEKAWMDGYSRQIFVTSKMLWPNGLTLDYHANVLYWCDAYYDHIERIFLNGTERKVIYSGKDLNHPFGLSHHGNHIYWTDYMNGSIFQLDLITRNVTLLRSERPPLFGLQIYDPRKQQGDNACRVNNGGCSTLCLAIPGGRVCACADNQFLEENSTTCMIKHGEPPPQLCKAEQFQCNNKRCIHDRWRCDGDDDCLDGSDEHADICFNHSCPENQFKCQNNRCIPKRWLCDGANDCGNNEDESNKTCAARTCQIDQFSCGNGRCIPTSWLCDREDDCGDQTDEMTSCEFPTCEPLTQFICENGRCISSKWLCDSDDDCGDGSDEVGCIHSCSADQFRCYNGRCIPSHWACDGDNDCGDYSDETRTNCTKEETPTPGRCSGKEFQCSPDGNCVPELWRCDGEKDCEDGSDEKGCNGTIRLCDERTKFSCVSTGRCISKAWLCDGDIDCEDQSDEDNCEGYMCGPPKYPCANDTSICLQPEKLCNGRRDCPDGSDEGDLCDECSLNNGGCSHQCSVVPGGRIVCSCPAGFNLSVDNKTCEIMDYCTKHLKCSQVCEQHKNNVKCSCYEGWKLSKDGENCISTDPFEAFIIFSIRHEIRKIDLHKRDYSLLVPGLRNTIALDFHFSQSLLYWTDVVEDKIYRGKLSDTGGVSAIEVVVQHGLATPEGLTVDWIAGNIYWIDSNLDQIEVAKLDGTLRTTLIAGAMEHPRAIALDPRYGILFWTDWDANFPRIESASMSGAERKIIYKDMDTGAWPNGLTVDHFEKRIVWTDARSDAIYSALYDGTGMIEIIRGHEYLSHPFAVSLYGSEVYWTDWRTNTLAKANKWTGQNVSVIQKTSAQPFDLQIYHPSRQPQASNPCAANEGRGPCSHMCLINHNRSAACACPHLMKLSLDKKTCYERKKFLLYARRSEIRGVDIDNPYFNFITAFTVPDIDDVTVIDFDAVEERLYWTDVKTQTIKRAFINGTGLETIISRDIQSIRGLAVDWISRNLYWISSEFDETQINVARLDGSLKTSIIHGIDKPQCLAVHPVKGKLYWTDGNTINMANMDGSNSKILFQNQKDPVGLSIDYVENKLYWISSGNGTINRCNLDGGNLEIIDSMKEDLPKATALTIMDKKLWWADQNLAQIGTCNKRDGRNPTILRNKTSGVVHMKVYDKAAQQGSNSCQFNNGGCSQLCLPTSETTRTCVCTVGYNLQKNRMACKGIESFVMYSVHEGIRGIPLDPNDKMEALMPISGTSFAVGIDFHAGNDTVYWTDMGFNKISRSKRDQTWKEDVVTNGLGRVEGIAVDWIAGNIYWTDHGFNLIEVARLNGSFRYVIISQGLDQPRSIAVHPEKGYLFWTEWGQIPCIGRAYLDGSEKVVLVSLGIVWPNGISIDYEENKLYWCDARTDKIERIDLESGGNREIVLSGSNVDMFSVAVFGAYIYWSDRAHANGSIRRGHKNEATDAVTMRTGLGINLKEVKVFNRAREKGTNICAKNNGGCHQLCLYRGNARRTCACAHGYLADDGITCLRHEGYLLYSGRTILKSIHLSDENNLNSPVRPYENPEYFKNVIALAFDYSLKGRGTNRIFFSDAHFGNIQVIKDNWAGRKVLIENVGSVEGLAYHRAWDTLYWTSSTTSSITRHTVDQRRRGAFNREAVITMSEDDHPHVLALDECQNLMFWTNWNEQLPSIMRSTLSGKNAQVIISTDILTPNGLTIDHRAEKLYFSDGSLGKIERCEYDGSQRYVIVKSGPGTFLSLAVYDDYVFWSDGVRRAILRSSKYTGGDTKVLRSDIPHQPMGIIAVANDTNSCELSPCAQMNGGCHDLCLLTPDGRVNCSCRGDRILIDDNRCVTKNSTCNIYSEFECGNGECIDYQLTCDGTAHCKDKSDEKLFYCENRGCRKGFKPCSNRRCILRNKVCDGTNDCGDNSDEFDCKDSACTSTEFRCADGTCIGKSARCNQIIDCADATDEKNCNNTNCAYFYKLGIKSTGFISCNSTSLCILPEWICDGSNDCGDYTDELKCPVQNKPTCEENYFGCPSGRCILNTWLCDGQKDCEDGVDELHCDSSCSWNQFACSADKCISKQWICDGEDDCGNGFDESDAICGSVTCAVGTFSCLGSHACVPQHWLCDGERDCPNGSDELSTAGCAPNNTCDENAFTCHNNICIPKQFVCDHDDDCGDGSDESLECGYRRCHPGEFTCADGRCLLNSQWQCDGDFDCPDHSDEAPINKKCRSSEQSCNSSFFMCKNGKCIPQSNVCNNKEDCSDGSDEKSCHINECLSKKVSGCSQDCQDLPVGYKCKCWPGFQLKDDGKTCTDIDECSSGFPCSQQCINTYGTYKCLCADGYEIQPDNLNGCKSLSDEEPFLILADHHEIRKISTDGSNYTLLKQGLNNVIAIDFDYREEFIYWIDSSRPNGSRINRMCLNGSDIKVVHNTAVPNALAVDWIGKNLYWSDTEKRIIEVSKVNGLYPTVLVSKRVKFPRNLSLDPQAGYLYWIDCCEYPHIGRVGMDGSSQTVVIETQISRPMALTIDYVNHRLYWADENHIEFSDMDGSHRHKVPNQDIPGVIALTLFEDYIYWTDGKTKSLNRAHKTSGLDRLSLINSWHTITDIQVYHSYRQPDVSKHLCTVNNGGCSHLCLLAPGKMHTCACPTNFYLAADNRTCLSNCTASQFRCKTDKCIPFWWKCDTVDDCGDGSDEPEECPEFRCQPGRFQCGTGLCALPAFICDGENDCGDNSDELNCDTHVCLTGQFKCTKNQKCIPINLRCNGQDDCGDEEDERDCPENSCSPDHFQCQTTKHCISKLWVCDEDPDCADGSDEANCGEYVSGLEYITVLSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UCG0</accession>
    <name>A0A8C2UCG0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RZZ complex subunit KNTC1/ROD C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UCG0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005036148.1">
        <property type="protein sequence ID" value="ENSCJPP00005026690.1"/>
        <property type="gene ID" value="ENSCJPG00005020744.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000007883"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005828">
        <property type="term" value="C:kinetochore microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990423">
        <property type="term" value="C:RZZ complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903394">
        <property type="term" value="P:protein localization to kinetochore involved in kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052802">
        <property type="entry name" value="KNTC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019527">
        <property type="entry name" value="RZZ-complex_KNTC1/ROD_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15688">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15688:SF1">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10493">
        <property type="entry name" value="Rod_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RZZ complex subunit KNTC1/ROD C-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005026690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="140" mass="16264" checksum="691334FEC16E7620" modified="2022-01-19" version="1">MLIPQSEKREQQIQAFLSTCNTETVLQQIDEHMNTGEVVAFASQIRSLILDSIINEKLYEKFLKTKYFPLVKQQLMSTHRMKELVDYFASKNRTEDAAALIREYQEKYGNPNLLDKSSSDLLKMYLNGPQETCVQELSHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UD39</accession>
    <name>A0A8C2UD39_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UD39"/>
    <dbReference type="Ensembl" id="ENSCJPT00005036521.1">
        <property type="protein sequence ID" value="ENSCJPP00005026978.1"/>
        <property type="gene ID" value="ENSCJPG00005020946.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00960000192850"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005026978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="59" mass="6429" checksum="B3643F043A1899C0" modified="2022-01-19" version="1">MESKPSRIPRRISVQAPSSTLGSRTLTGNSLAGAYSARDSSRRLDSGYQVMCFDFLCEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UD62</accession>
    <name>A0A8C2UD62_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Interferon regulatory factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">IRF1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2UD62"/>
    <dbReference type="Ensembl" id="ENSCJPT00005036588.1">
        <property type="protein sequence ID" value="ENSCJPP00005027014.1"/>
        <property type="gene ID" value="ENSCJPG00005020982.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156288"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="C:nucleus"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
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        <property type="term" value="P:apoptotic process"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0043374">
        <property type="term" value="P:CD8-positive, alpha-beta T cell differentiation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:cellular response to interferon-beta"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:defense response to virus"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:positive regulation of interferon-beta production"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:positive regulation of interleukin-12 production"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:regulation of CD8-positive, alpha-beta T cell proliferation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:regulation of cell cycle"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0034124">
        <property type="term" value="P:regulation of MyD88-dependent toll-like receptor signaling pathway"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:transcription by RNA polymerase II"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="IRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000065">
        <property type="entry name" value="Interferon regulatory factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR019817">
        <property type="entry name" value="Interferon_reg_fac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001346">
        <property type="entry name" value="Interferon_reg_fact_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11949">
        <property type="entry name" value="INTERFERON REGULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11949:SF3">
        <property type="entry name" value="INTERFERON REGULATORY FACTOR 1"/>
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    </dbReference>
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        <property type="entry name" value="IRF"/>
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        <property type="entry name" value="INTFRNREGFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00348">
        <property type="entry name" value="IRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00601">
        <property type="entry name" value="IRF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51507">
        <property type="entry name" value="IRF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="IRF tryptophan pentad repeat" evidence="10">
        <location>
            <begin position="50"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="155"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="162"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51507"/>
        </source>
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        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005027014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="371" mass="41913" checksum="B2672C0E4415F9DF" modified="2022-01-19" version="1">MEQKAPSAALVTGSAGRAGRGEALRGGWGRRDEVSADPVYPPAGNMPVSRMRMRPWLEMQINSNQIPGLIWINKDKMIFQIPWKHAAKHGWDMEKDACLFRSWAIHTGRYKVGEKDPDPKTWKANFRCAMNSLPDIEEVKDKSINKGSSAVRVYRMLPPLTKDQKKERKSKSSREARNKSKRKLYEDMRTEESAERLTSTPLPDDHSSYTAHDYTGQEVEVENTSITLDLSSCEVSGSLNDWRMPMEIAMADSTNDIYHHLQVSPLGSSSEDEDEMNSNLIKMLEPTPTQDWHTTSVEGKGFFTNEPGTQNMCSTFGYKEQDGEIDKSGTKTRYHCGPGGRHRKGFSSETLLELGGRNRNLMTWETVNSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UDA2</accession>
    <name>A0A8C2UDA2_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Glypican 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">GPC5</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Cell surface proteoglycan.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Lipid-anchor</topology>
            <topology evidence="1 12">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glypican family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2UDA2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005033603.1">
        <property type="protein sequence ID" value="ENSCJPP00005024689.1"/>
        <property type="gene ID" value="ENSCJPG00005019430.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01050000244955"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090263">
        <property type="term" value="P:positive regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905475">
        <property type="term" value="P:regulation of protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001863">
        <property type="entry name" value="Glypican"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019803">
        <property type="entry name" value="Glypican_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10822">
        <property type="entry name" value="GLYPICAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10822:SF12">
        <property type="entry name" value="GLYPICAN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01153">
        <property type="entry name" value="Glypican"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01207">
        <property type="entry name" value="GLYPICAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 12" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="9 12" id="KW-0357">Heparan sulfate</keyword>
    <keyword evidence="10 12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0654">Proteoglycan</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034684800" evidence="13">
        <location>
            <begin position="25"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010260"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005024689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="568" mass="63755" checksum="09250225E6CCAEBE" modified="2022-01-19" version="1">MEARSLSVLLLLLAAAATPAPRDGEPRSCEAVRKVFQLRQLGSFRGVPEFPRAGVDLQVCTSKNPTCCTKKMEERYQTAAKQDIQQVLQTSSATLKFLISRNAAAFQETFEMLIKLAENYTSTLFCNAYRNMAAEAATRVQEFFTDIALYIFGTDISTKECVNRFFDNLFPVVYNHMINPGLTDVTLEYAECLQMVRRDIRPFGDIPEKVIRQMGRSLLPSRNFLQALNLGIEVINTTDHLHFSKDCSRALLRMQYCPHCQGLILSKPCMGYCLNVIRGCLAYVAEVDLHWQGYIQSLEELSSAMHGTYDVEHVLLNFHSLVNDALMQARVNGPELTEQVNKVCGPPVRKPTQSPHCSFDRNKYSQGLKMFSRDVEETLASRRKEFISHLRLYRAFYGGLADQLCGNELAAADDIPCWNGEDVVKSYTHHVVGSGIKAQAGNPEVRVKGTDPVINQIIDKLKHIIQLLRGKSFPKYDNWDLRQTGSGGSVDEQISGVCDDEDGCGGSGSGEVKRVLKITDCKSMIPFPSYIQRVKLSYVPLGNTIELFWKKCAEVVYIMFPRYTGIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UE80</accession>
    <name>A0A8C2UE80_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Calcium release-activated calcium channel protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Protein orai-1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Transmembrane protein 142A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">ORAI1</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Orai family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015733624.1">
        <property type="nucleotide sequence ID" value="XM_015878138.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UE80"/>
    <dbReference type="Ensembl" id="ENSCJPT00005036062.1">
        <property type="protein sequence ID" value="ENSCJPP00005026610.1"/>
        <property type="gene ID" value="ENSCJPG00005020697.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107321339"/>
    <dbReference type="KEGG" id="cjo:107321339"/>
    <dbReference type="CTD" id="84876"/>
    <dbReference type="GeneTree" id="ENSGT00390000015354"/>
    <dbReference type="OrthoDB" id="61124at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044853">
        <property type="term" value="C:plasma membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015279">
        <property type="term" value="F:store-operated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070509">
        <property type="term" value="P:calcium ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990806">
        <property type="term" value="P:ligand-gated ion channel signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007200">
        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051928">
        <property type="term" value="P:positive regulation of calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032024">
        <property type="term" value="P:positive regulation of insulin secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002115">
        <property type="term" value="P:store-operated calcium entry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.140:FF:000001">
        <property type="entry name" value="Calcium release-activated calcium modulator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.140">
        <property type="entry name" value="Calcium release-activated calcium channel protein Orai"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012446">
        <property type="entry name" value="CRAC_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038350">
        <property type="entry name" value="Orai_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31501">
        <property type="entry name" value="CALCIUM RELEASE-ACTIVATED CALCIUM CHANNEL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31501:SF3">
        <property type="entry name" value="CALCIUM RELEASE-ACTIVATED CALCIUM CHANNEL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07856">
        <property type="entry name" value="Orai-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="5" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0391">Immunity</keyword>
    <keyword evidence="15" id="KW-0407">Ion channel</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="111"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00039339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00041729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00042240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005026610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="226" mass="25099" checksum="3E62056B733B1954" modified="2022-01-19" version="1">MSLNEHSMQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLDAEHDYPRGLLIAFSACTTVLVAVHLFALMISTCILPNIEAVSNVHNLNSVKESPHERMHRHIELAWAFSTVIGTLLFLAEVVLLCWVKFLPLKKNPLDPAQNSNSSITSGQAAAIASTSIMVPFGLIFIVFAVHFYRSLVSHKTDRQFQELNELAEFARLQDQLDHRGDAISPAVTHFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UE96</accession>
    <name>A0A8C2UE96_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transmembrane protein 178B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">TMEM178B</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM178 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015722231.1">
        <property type="nucleotide sequence ID" value="XM_015866745.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UE96"/>
    <dbReference type="Ensembl" id="ENSCJPT00005035209.1">
        <property type="protein sequence ID" value="ENSCJPP00005025939.1"/>
        <property type="gene ID" value="ENSCJPG00005020271.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107315866"/>
    <dbReference type="KEGG" id="cjo:107315866"/>
    <dbReference type="CTD" id="100507421"/>
    <dbReference type="GeneTree" id="ENSGT00390000015299"/>
    <dbReference type="OrthoDB" id="8809386at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004031">
        <property type="entry name" value="PMP22/EMP/MP20/Claudin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039625">
        <property type="entry name" value="T178A/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32005:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 178B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32005">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 178B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13903">
        <property type="entry name" value="Claudin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034138583" evidence="8">
        <location>
            <begin position="24"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005025939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="294" mass="33226" checksum="20205E70EDBE932F" modified="2022-01-19" version="1">MAAGRLLLYAGLSLALCALGMLAVAICSDHWYETDARKHRERCKSITTKRNDPGFIYNSNNNLPLRASRSRLDRWEGKLLLARNRRQIFAMSAVDECNRQYNSTNMGLWRKCHRQGFDQELEELIAKGAIERCSYIKYHYSSATIPKNLTYNITKTIRQDEWHALHLRRMTAGFMGMAVAIILFGWIIGVLGCCWDRGLMQYVAGLLFLMGGTFCIISLCTCVAGINFELSRYPRYVYGLPEDISHGYGWSMFCAWGGLGLTLISGFFCTLAPSVQPVPRTNCPKSRPENGTVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UEA9</accession>
    <name>A0A8C2UEA9_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Myeloid-associated differentiation marker-like protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">MYADML2</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MAL family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2UEA9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005036819.1">
        <property type="protein sequence ID" value="ENSCJPP00005027200.1"/>
        <property type="gene ID" value="ENSCJPG00005021101.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182933"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047123">
        <property type="entry name" value="MYADM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17068">
        <property type="entry name" value="MYELOID-ASSOCIATED DIFFERENTIATION MARKER MYADM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17068:SF5">
        <property type="entry name" value="MYELOID-ASSOCIATED DIFFERENTIATION MARKER-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51225">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="10">
        <location>
            <begin position="14"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="10">
        <location>
            <begin position="154"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005027200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="302" mass="33210" checksum="57AD0E03BB0F8B74" modified="2022-01-19" version="1">MMESTGGPYLNTAAVTSPVGIVRLLQMMFGCTTFSLVAHQGGFSAAYGTFCMFVWTFCFAVTVFITTCEFTHLHSCLSISWGNFTAAFAMLATLMSVTAAVIYPLYFVQLGCYPITCEVRDFRIAASVFAGLVFIVYGVEVFLTRAKPGQVTSYMATVSGLLKIVQAFVACIIFGALVNDSQYSKYVATQWCVAVYSFCFMVTVVVVAFSVTGKTAQLCFPFERSVVVYTFGAVLLYVSAAVIWPVFCFDSKYGSPQRPSACAKGRCPWDSQLVVAIFTYINLLLYVVDLAYSQRIRFVSHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UFE2</accession>
    <name>A0A8C2UFE2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyclin-I</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">CCNI2</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2UFE2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005036577.1">
        <property type="protein sequence ID" value="ENSCJPP00005027003.1"/>
        <property type="gene ID" value="ENSCJPG00005020976.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162679"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="CDD" id="cd20526">
        <property type="entry name" value="CYCLIN_CCNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000006">
        <property type="entry name" value="Cyclin I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000052">
        <property type="entry name" value="cyclin-I isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0195">Cyclin</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="44"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="331"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="349"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00073755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005027003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="359" mass="40019" checksum="9CE5E540EAE33755" modified="2022-01-19" version="1">MKCPGPPESSRLVCFLENALVREARIWKAPGTDISPLCYEKTILWIAEISSQFQFHSETFALSISILNRLLASVKARLKYLQCIAISCLVLAAKTNEEDEVIPSVKTLAEQSGCKCSPAEILRMERTILDKLHWDLYTATPMDFLSIFHAMVMSNWPHLLNGLPQTNPSRHVALLTKQLQHCMACHQLVQFKGSTLALVIITLELERQTPDWFPVITDLLKKAQITSTEFKHCKELVDQELMHLQPSNAIYIFCPISQATHGDAEAKFPCHYPSEFKSSHQVRLQVAVSQPVSAAVTSATAQIPEGTMETDEYYDGLRYLYSENRGADGRRVHRGGLCPQLKSGGGSSPCPPLQPPGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UG74</accession>
    <name>A0A8C2UG74_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transmembrane protein 121</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">TMEM121</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TMEM121 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015725004.1">
        <property type="nucleotide sequence ID" value="XM_015869518.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015725005.1">
        <property type="nucleotide sequence ID" value="XM_015869519.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015725006.1">
        <property type="nucleotide sequence ID" value="XM_015869520.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UG74"/>
    <dbReference type="Ensembl" id="ENSCJPT00005037004.1">
        <property type="protein sequence ID" value="ENSCJPP00005027363.1"/>
        <property type="gene ID" value="ENSCJPG00005021226.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107317172"/>
    <dbReference type="KEGG" id="cjo:107317172"/>
    <dbReference type="CTD" id="80757"/>
    <dbReference type="GeneTree" id="ENSGT00390000003866"/>
    <dbReference type="OrthoDB" id="9926693at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032776">
        <property type="entry name" value="CECR6/TMEM121"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042314">
        <property type="entry name" value="TMEM121"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31046">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31046:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14997">
        <property type="entry name" value="CECR6_TMEM121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005027363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="312" mass="35666" checksum="1459C8F504C96A48" modified="2022-01-19" version="1">MVLPPPDKRHVCLTTIVIMTSMAFMDAYLVEQNQGPRKIGVCIIVLVGDICFLIVLRYVAVWVGAEVKTAKRGYAMILWFLYIFVLEIKLYFIFQNYKADKKNLETVARKALTLLLSICVPGLYLVLVALDSMEYIRTFRKKEDLRGRLFWVALDLLDILDIQANLWEPQKKGLPIWAEGLMFFYCYILLLILPCVSLSEISMQGEHIAPQKMMLYPVLSLVTINIVTIFIRAINMVLFQDSRVSTIFIGKNIIAIATKACTFLEYKRQVKEFPQNAIALELQQNSLSHNQTIHSTQGIPHEPSPTSEILDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UIL7</accession>
    <name>A0A8C2UIL7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP synthase subunit f, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">MTNAP1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase F chain family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2UIL7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005037064.1">
        <property type="protein sequence ID" value="ENSCJPP00005027420.1"/>
        <property type="gene ID" value="ENSCJPG00005021261.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107322282"/>
    <dbReference type="KEGG" id="cjo:107322282"/>
    <dbReference type="CTD" id="55028"/>
    <dbReference type="GeneTree" id="ENSGT00940000167290"/>
    <dbReference type="OrthoDB" id="8921675at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006754">
        <property type="term" value="P:ATP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019344">
        <property type="entry name" value="F1F0-ATPsyn_F_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037694">
        <property type="entry name" value="MTNAP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16270">
        <property type="entry name" value="HYPOTHETICAL LOC287798"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16270:SF5">
        <property type="entry name" value="HYPOTHETICAL LOC287798"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10206">
        <property type="entry name" value="WRW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4" id="KW-0138">CF(0)</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="117"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="117"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005027420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="431" mass="48091" checksum="D8D4079551EE5B13" modified="2022-01-19" version="1">MADAPLGTELCPHCRRPFKRLRSHLPHCKAAPGRETETTGRWEGLAAEVKGEEVLRKRRKQQKQQQAAVRPRVEVEAEARDVAQCLDLLPEEVEGVPEKLRDGVKIVIENHRVKVLRDRNGPKAGRQREEGHKGLKSTGPEGRNTPKSAHTVIPDHRAPSSKGGKDTALNGVKTRGLRGPPEAESTRSPPDLAQQEGTDKRLVEEKQVYTGSAVEYKAPIAVLHAHLAAREDWRGHKEWTSKNDLTDTQMLSVNKKQMAVVSEPILNAGRDSRLALDHSLLHTSKSQPICLPQASGRSTQSGAVGLEWFPDLHSNYHSLSMFPGKSFQDDVGITMKTPKGNFSEGHQGPLSERHLMDVRLGELPMWLTTCDFSPRGLLGGVQKVWSSYYNKYINVKRGGAAGISMLLAGYCVLSYSWNYQHIKCNRWRKYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UJH2</accession>
    <name>A0A8C2UJH2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-histidine N-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">METTL18</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the methyltransferase superfamily. METTL18 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.85" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2UJH2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005037408.1">
        <property type="protein sequence ID" value="ENSCJPP00005027720.1"/>
        <property type="gene ID" value="ENSCJPG00005021448.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000000464"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018064">
        <property type="term" value="F:protein-L-histidine N-tele-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090069">
        <property type="term" value="P:regulation of ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000232">
        <property type="term" value="P:regulation of rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006448">
        <property type="term" value="P:regulation of translational elongation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF39">
        <property type="entry name" value="HISTIDINE PROTEIN METHYLTRANSFERASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="52"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="221"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="223"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005027720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="363" mass="40898" checksum="DD463B704DE7BD0E" modified="2022-01-19" version="1">MQLQKQHSLSLPLPGTNCWTDRCKITFLFVSQHCRLLFLSMDFRFNFFPDEDESKEPSADNETQPCSPTQQDERQPERKGCIKAAKEHRVPEDISEVLRNKVLETASGLHYVNMAVVEMTCRDGSHEEDIVSKSVSSHSDLIPGVYEGGMKIWECTYDLMDFLAEAEIRFNNKTVLDLGCGAGLLGIVALKGDAAEVHFQDYNSTVIEEITMPNVVANCINDGNKDSKEDGKNIKPPSKRRKESEPLPDELSKCRFFSGGWAEVSQLLSSSSKPCIKYDLILTSETIYNPDYYGALHDTLAQLLAKDGRVYLASKVHYFGVGGGTYLFEKFLEERKVFRSSTVKEVEEGLKRFVLEIAFQDST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y656</accession>
    <name>A0A8C2Y656_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y656"/>
    <dbReference type="Ensembl" id="ENSCJPT00005005148.1">
        <property type="protein sequence ID" value="ENSCJPP00005002786.1"/>
        <property type="gene ID" value="ENSCJPG00005003088.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005002786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="84" mass="8854" checksum="460A9E8A720E3B4E" modified="2022-01-19" version="1">MRAKHIKLKLSALTPISVIVHACPRLPAPAPGSSSPFRTPWWAALNTTSLLAAAVPPALPGSHLISSNKTTQKMCQFEAEVLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y692</accession>
    <name>A0A8C2Y692_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcription elongation factor A2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TCEA2</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y692"/>
    <dbReference type="Ensembl" id="ENSCJPT00005006285.1">
        <property type="protein sequence ID" value="ENSCJPP00005003565.1"/>
        <property type="gene ID" value="ENSCJPG00005003707.1"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 20"/>
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        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="C:ciliary basal body"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
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        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
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        <property type="entry name" value="Transcription elongation factor S-II, central domain"/>
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        <property type="entry name" value="TFIIS_N"/>
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        <property type="entry name" value="TFSII"/>
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        <property type="entry name" value="TFSII"/>
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        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR A PROTEIN 2"/>
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    <dbReference type="PANTHER" id="PTHR11477">
        <property type="entry name" value="TRANSCRIPTION FACTOR S-II ZINC FINGER DOMAIN-CONTAINING PROTEIN"/>
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        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="TFIIS_M"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="TFS2M"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
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        <property type="entry name" value="Elongation factor TFIIS domain 2"/>
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        <property type="entry name" value="TFIIS_CENTRAL"/>
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        <property type="entry name" value="TFIIS_N"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="5">
        <location>
            <begin position="75"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS central" evidence="6">
        <location>
            <begin position="209"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="45"/>
            <end position="69"/>
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    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="152"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="166"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
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    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51321"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005003565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="434" mass="47062" checksum="0E88FDD3E8853074" modified="2022-01-19" version="1">MLGVVVPPLGLALGGGGRVGATRTTNPIVPRAPPVRTAVAGVEVGNGNNRRPSVPPPSQPPGIVATGSGAMGGEEEIVRIAKRLDKMVAKKNADGAMDLLKELKSMPMTLDLLQSTRIGMSVNALRKQSTDEEVIALAKSLIKSWKKLLDASEEKSEEKKKNLSLPTSSSKETGNSRDQSSNKRQEPPKTPTTPKITTFPPAPITCDAVRNKCREMLTTALQADDDYIAIGADCEHIAAQIEECIYQDIKNTDMKYKNRVRSRISNLKDSKNPELKKNVLCGAITPEQIAVMTSEEMASNELKEIRKAMTKEAIREHQMAKTGGTQTDLFTCGKCKKKNCTYTQVRLPAPPASLALSSAQETICHGLEVSLLLSTPCSMAETLLLVGRSFWHAQCSLKYSTDGFGGIFCWSLCNFVQMLLYGRAGLVQCQGMSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y6D4</accession>
    <name>A0A8C2Y6D4_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Abl interactor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ABI1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Filopodium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Lamellipodium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ABI family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015708726.1">
        <property type="nucleotide sequence ID" value="XM_015853240.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y6D4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005006628.1">
        <property type="protein sequence ID" value="ENSCJPP00005003805.1"/>
        <property type="gene ID" value="ENSCJPG00005003924.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107308954"/>
    <dbReference type="KEGG" id="cjo:107308954"/>
    <dbReference type="CTD" id="10006"/>
    <dbReference type="GeneTree" id="ENSGT00940000154811"/>
    <dbReference type="OrthoDB" id="2159336at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032433">
        <property type="term" value="C:filopodium tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031209">
        <property type="term" value="C:SCAR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030296">
        <property type="term" value="F:protein tyrosine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048813">
        <property type="term" value="P:dendrite morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072673">
        <property type="term" value="P:lamellipodium morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035855">
        <property type="term" value="P:megakaryocyte development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001764">
        <property type="term" value="P:neuron migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001756">
        <property type="term" value="P:somitogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd11971">
        <property type="entry name" value="SH3_Abi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000002">
        <property type="entry name" value="abl interactor 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028457">
        <property type="entry name" value="ABI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035725">
        <property type="entry name" value="Abi1_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012849">
        <property type="entry name" value="Abl-interactor_HHR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10460:SF2">
        <property type="entry name" value="ABL INTERACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10460">
        <property type="entry name" value="ABL INTERACTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07815">
        <property type="entry name" value="Abi_HHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="14">
        <location>
            <begin position="45"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="13">
        <location>
            <begin position="446"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="159"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="388"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="161"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="222"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="248"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="278"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="307"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="323"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="393"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="410"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005003805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="508" mass="54991" checksum="D544EF74867E75D7" modified="2022-01-19" version="1">MAELQMLLEEEIPSGKRALLESYQNLTRVADYCENNYIQAPDKRKALEETKAYTTQSLASVAYQINALANNVLQLLDIQASQLRRMESSINHISQTVDIHKEKVARREIGILTTNKNTSRTHKIIAPANMERPVRYIRKPIDYTVLDDVGHGVKWLKAKHGNNQPARTGTLSRTNPPTQKPPSPPMSGRGTLGRNTPYKTLEPVKPPTVPNDYMTSPARLGSQHSPGRTASLNQRPRTHSGSSGGSGSRENSGSSSIGIPIAVPTPSPPTIGPAHISVPPPPGAPPAPPLPPPLPMGSLIAAPGSAPGSQYGTMTRQISRHNSTTSSASSGGYRRNPSVTAPFSAQPHVNGGPLYSQNSISIAPPPPPMPQLTPQIPLTGFVARVQENIADSPTPPPPPPPDEMPMFDDSPPPPPPPPVDYEDEEAAVVQYSDPYADGDPAWAPKNYIEKVVAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGVCNRVTGLFPGNYVESIMHYAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y6M6</accession>
    <name>A0A8C2Y6M6_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">X-C motif chemokine receptor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">XCR1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y6M6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005007299.1">
        <property type="protein sequence ID" value="ENSCJPP00005004360.1"/>
        <property type="gene ID" value="ENSCJPG00005004323.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01110000267168"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019957">
        <property type="term" value="F:C-C chemokine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016493">
        <property type="term" value="F:C-C chemokine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060326">
        <property type="term" value="P:cell chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007204">
        <property type="term" value="P:positive regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd15182">
        <property type="entry name" value="7tmA_XCR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000130">
        <property type="entry name" value="Chemokine (C-C motif) receptor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050119">
        <property type="entry name" value="CCR1-9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005393">
        <property type="entry name" value="Chemokine_XCR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10489">
        <property type="entry name" value="CELL ADHESION MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10489:SF730">
        <property type="entry name" value="CHEMOKINE XC RECEPTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01568">
        <property type="entry name" value="LYMPHOTACTNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="47"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005004360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="331" mass="38490" checksum="2E6C86696E8C998B" modified="2022-01-19" version="1">METKQNNYSFEYFLNESNVCEMGNYFTFYTHLTTVLYTLAFLLSLLGNTLVLWILFKYENLTSLTNIFIMNLCVSDLVFSCMLPFWAVDQTFGWIFGEFLCKAVNAIFSVGYYSGVFFLTLMTILRYLYVVNPLSTLRSQTQYCGSLVCLFVWTCSILIVVPEMIHTTVVETLEEVSACDYDDWKWKKVDIYQRNILFLISFGIIVFCYINILIILLGTRSRRKQRTVKLILVIVVAFFLSWAPYNILSFLTTFPPPSCQYEKDIVLAFHISRKIAFSHCCLNPVLYAFAGVKFKRHLFRLCRQYLPCGDEVSSPRIGSQGKFHYEDASIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y7P4</accession>
    <name>A0A8C2Y7P4_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Lon protease homolog, mitochondrial</fullName>
            <ecNumber evidence="11">3.4.21.53</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 20" type="primary">LONP1</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>Hydrolysis of proteins in presence of ATP.</text>
            <dbReference type="EC" id="3.4.21.53"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homohexamer or homoheptamer. Organized in a ring with a central cavity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11 12 15 16">Belongs to the peptidase S16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.53" evidence="11"/>
    <dbReference type="RefSeq" id="XP_015742060.1">
        <property type="nucleotide sequence ID" value="XM_015886574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y7P4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005010257.1">
        <property type="protein sequence ID" value="ENSCJPP00005006502.1"/>
        <property type="gene ID" value="ENSCJPG00005006078.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107325567"/>
    <dbReference type="KEGG" id="cjo:107325567"/>
    <dbReference type="CTD" id="9361"/>
    <dbReference type="GeneTree" id="ENSGT00530000063553"/>
    <dbReference type="OrthoDB" id="2411602at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070182">
        <property type="term" value="F:DNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051880">
        <property type="term" value="F:G-quadruplex DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070407">
        <property type="term" value="P:oxidation-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001666">
        <property type="term" value="P:response to hypoxia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd19500">
        <property type="entry name" value="RecA-like_Lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000021">
        <property type="entry name" value="Lon protease homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000043">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.5270:FF:000001">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1480:FF:000002">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.130.40:FF:000004">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000015">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.5270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="entry name" value="LON domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03120">
        <property type="entry name" value="lonm_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004815">
        <property type="entry name" value="Lon_bac/euk-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054594">
        <property type="entry name" value="Lon_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027503">
        <property type="entry name" value="Lonm_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008268">
        <property type="entry name" value="Peptidase_S16_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00763">
        <property type="entry name" value="lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43718">
        <property type="entry name" value="LON PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43718:SF2">
        <property type="entry name" value="LON PROTEASE HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22667">
        <property type="entry name" value="Lon_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001174">
        <property type="entry name" value="Lon_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00830">
        <property type="entry name" value="ENDOLAPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01046">
        <property type="entry name" value="LON_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 11 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 11 12" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 12" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="19">
        <location>
            <begin position="106"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="18">
        <location>
            <begin position="740"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="28"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="202"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="17">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="active site" evidence="11 13 15">
        <location>
            <position position="833"/>
        </location>
    </feature>
    <feature type="active site" evidence="11 13 15">
        <location>
            <position position="876"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11 14">
        <location>
            <begin position="504"/>
            <end position="511"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR001174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001174-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001174-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="933" mass="103855" checksum="71AFF0A82FE58DEB" modified="2022-01-19" version="1">MAAARCLRLCVRWRPVLLGPARRRVPAAASSVSPAAPTGPAPPPRAALSTAPRWQRWSNGGLAGGDGLEGGGGGEENGGGGAEPGGSAPVMTALTPLMVPEHFPNVPLIAVTRNPVFPRFIKIIEVKNKKLVELLRRKVRLAQPYAGVFLKKDDNNESDVVEDLNEIYQMGTFVQIHEMQDLGDKLRMIVMGHRRIRINRQLEVEPEEPEGKQKARRKQKRTKKEAEEEPGVKEQAVEVVLDPVAASSQEVLMVEVENVVHEDFQITEEVKALTAEIVKTIRDIIALNPLYRESVLQMMQAGQRVVDNPIYLSDMGAALTGAESHELQDILEETSIPKRLYKALSLLKKEYELSKLQQRLGREVEEKIKQTHRKYLLQEQLKIIKKELGLEKEDKDAIEEKFRERLKELVVPKHVMDVIDEELNKLSLLDNHSSEFNVTRNYLDWLTSIPWGKCSEENLELSRAQAVLEEDHYGMDDVKKRILEFIAVSQLRGSTQGKILCFYGPPGVGKTSIARSIARALNREYFRFSVGGMTDVAEIKGHRRTYVGAMPGKIIQCLKKTKTENPLILIDEVDKIGRGYQGDPSSALLELLDPEQNSNFLDHYLDVPVDLSKVLFICTANVTETIPEPLRDRMEVINVSGYVAEEKLAIAERYLVPQARALCGLDENKAKITSDVLTVLIKQYCRESGVRNLQKQVEKVLRKSAYKIVSGEVEMVQVTPENLQDFVGKPIFTVDRMYETTPPGVVMGLAWTAMGGSTLFIETSLKRPKDTEGKDGSLEVTGQLGDVMKESAKIAYTFARAFLMQKEPNNDFLMSSHIHLHVPEGATPKDGPSAGCTIVTALLSLAMNCPVRQNVAMTGEVSLTGKILPVGGIKEKTIAAKRAGVTCIILPSENKKDYYDLAGFITEGLEVHFVEHYKEVFDIAFSKRDLAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y7R1</accession>
    <name>A0A8C2Y7R1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Riboflavin transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">SLC52A3</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>riboflavin(in) = riboflavin(out)</text>
            <dbReference type="Rhea" id="RHEA:35015"/>
            <dbReference type="ChEBI" id="CHEBI:57986"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cell membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the riboflavin transporter family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015737434.1">
        <property type="nucleotide sequence ID" value="XM_015881948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y7R1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005009833.1">
        <property type="protein sequence ID" value="ENSCJPP00005006215.1"/>
        <property type="gene ID" value="ENSCJPG00005005832.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107323142"/>
    <dbReference type="KEGG" id="cjo:107323142"/>
    <dbReference type="CTD" id="113278"/>
    <dbReference type="GeneTree" id="ENSGT00390000003774"/>
    <dbReference type="OrthoDB" id="9995836at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032217">
        <property type="term" value="F:riboflavin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072388">
        <property type="term" value="P:flavin adenine dinucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006771">
        <property type="term" value="P:riboflavin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007605">
        <property type="term" value="P:sensory perception of sound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009357">
        <property type="entry name" value="Riboflavin_transptr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12929">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12929:SF4">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 52, RIBOFLAVIN TRANSPORTER, MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06237">
        <property type="entry name" value="SLC52_ribofla_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="105"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="347"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="414"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="454" mass="49313" checksum="C4CC5719C5E896AF" modified="2022-01-19" version="1">MALLTHLLACVFGTGSWVAINGLWVELPLLVSVLPEQWDLPSYITIIIQMANIGPLFVTLMHRFWPGSLKEVVVIYVVVSVGIVACLLLAFLWDYTSPIAGTTHSTAFLILTFFLSLVDCTSSVTFLPFMMQLQAQYLTTFFIGEGLSGLIPALIALGQGSGISSCANVSQVVNITSDNETMEGTVFQMETRYLPARFSTFIFFLLMAAMMVACLVAFFFLTRQPKVWELSQQQLCPSTIILNSFDQILEDGGGTARGEGYSCPKSTKGPMETHPEKVSYSVAKLAFIYLLITWVSSLTNGVLPSVQSYSCLPYGNTAYHLSATLSSMANPLACIVAMVLPSRSLALLGALSLAGTGFGAYNMAIAVMSPCPLLQHSQWGDAIIILSWVLFTGTLSYVKVMAGVILRSRSHSALVWYGALEQLGSLLGALLMFPLVNIYGFFQSADYCSLQCPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y9W4</accession>
    <name>A0A8C2Y9W4_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Sodium/potassium-transporting ATPase subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">ATP1B3</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-3 subunit is not known.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 18">Belongs to the X(+)/potassium ATPases subunit beta family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015726965.1">
        <property type="nucleotide sequence ID" value="XM_015871479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y9W4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005015854.1">
        <property type="protein sequence ID" value="ENSCJPP00005010765.1"/>
        <property type="gene ID" value="ENSCJPG00005009320.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107318078"/>
    <dbReference type="KEGG" id="cjo:107318078"/>
    <dbReference type="CTD" id="483"/>
    <dbReference type="GeneTree" id="ENSGT01030000234579"/>
    <dbReference type="OrthoDB" id="5912413at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005890">
        <property type="term" value="C:sodium:potassium-exchanging ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036126">
        <property type="term" value="C:sperm flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141109">
        <property type="term" value="F:transporter activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0086009">
        <property type="term" value="P:membrane repolarization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903288">
        <property type="term" value="P:positive regulation of potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903278">
        <property type="term" value="P:positive regulation of sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000068">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1660:FF:000005">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1660">
        <property type="entry name" value="Na, k-atpase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000402">
        <property type="entry name" value="Na/K_ATPase_sub_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038702">
        <property type="entry name" value="Na/K_ATPase_sub_beta_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01107">
        <property type="entry name" value="Na_K_ATPase_bet"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11523">
        <property type="entry name" value="SODIUM/POTASSIUM-DEPENDENT ATPASE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11523:SF47">
        <property type="entry name" value="SODIUM_POTASSIUM-TRANSPORTING ATPASE SUBUNIT BETA-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00287">
        <property type="entry name" value="Na_K-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00390">
        <property type="entry name" value="ATPASE_NA_K_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00391">
        <property type="entry name" value="ATPASE_NA_K_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 18" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="11" id="KW-0915">Sodium</keyword>
    <keyword evidence="16" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="6" id="KW-0740">Sodium/potassium transport</keyword>
    <keyword evidence="7 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 18" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00037667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU362099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005010765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="280" mass="31868" checksum="5EC5A126280E4EE1" modified="2022-01-19" version="1">MSKETKKPFRQSVAEWRQFVYNPNSGEFLGRTAKSWGLILLFYLVFYGFLAALFTFTMWVMLQTLSSDIPKYRDRISSPGLMISPKPDTALEFYFNKSDAQTYAEYVSTLRKFLETYDDSKQSQNINCTPGKVFDQNDVAVKKACRFNLSELGQCSGKEDKTFGYSKGTPCVLVKMNRIIGLKPEGEPYIQCTSKDPGAVEMNYFPSGGMIDLMYFPYYGKALHAHYLQPLVAVQLAINSNSTNEEITIECKILGSPNLKNEDDRDKFLGRIAFKVEMTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YBH9</accession>
    <name>A0A8C2YBH9_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Anterior gradient 2, protein disulphide isomerase family member</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">AGR2</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the AGR family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2YBH9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005020268.1">
        <property type="protein sequence ID" value="ENSCJPP00005014192.1"/>
        <property type="gene ID" value="ENSCJPG00005011874.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063273"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002162">
        <property type="term" value="F:dystroglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005154">
        <property type="term" value="F:epidermal growth factor receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048546">
        <property type="term" value="P:digestive tract morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060480">
        <property type="term" value="P:lung goblet cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070254">
        <property type="term" value="P:mucus secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010811">
        <property type="term" value="P:positive regulation of cell-substrate adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048639">
        <property type="term" value="P:positive regulation of developmental growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045742">
        <property type="term" value="P:positive regulation of epidermal growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903896">
        <property type="term" value="P:positive regulation of IRE1-mediated unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903899">
        <property type="term" value="P:positive regulation of PERK-mediated unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903078">
        <property type="term" value="P:positive regulation of protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd02960">
        <property type="entry name" value="AGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000036">
        <property type="entry name" value="anterior gradient protein 2 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051099">
        <property type="entry name" value="AGR/TXD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15337:SF1">
        <property type="entry name" value="ANTERIOR GRADIENT PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15337">
        <property type="entry name" value="ANTERIOR GRADIENT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13899">
        <property type="entry name" value="Thioredoxin_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034753983" evidence="7">
        <location>
            <begin position="32"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005014192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="189" mass="21627" checksum="4E09F6B1EF9A10C3" modified="2022-01-19" version="1">MKALFLIPGAAMEKSYVSVFLLLVAISCVLAKDIGKKETKETKPKLPQTLSRGWGDQLIWTQTYEEALFRSKNSNKPLMIIHHLDDCPHSQALKKVFAEHKEIQKLAEKFILLNLVYETTDKNLAPDGQYVPRILFIDPSLTVRADITGRYSNRLYAYEPSDISLLYSNMQKALKRSSQVSSAWQIYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YBL8</accession>
    <name>A0A8C2YBL8_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Integrin subunit beta 1 binding protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ITGB1BP2</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YBL8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005020513.1">
        <property type="protein sequence ID" value="ENSCJPP00005014408.1"/>
        <property type="gene ID" value="ENSCJPG00005012034.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159429"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd06488">
        <property type="entry name" value="p23_melusin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1130.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007051">
        <property type="entry name" value="CHORD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039790">
        <property type="entry name" value="CHRD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46983">
        <property type="entry name" value="CYSTEINE AND HISTIDINE-RICH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46983:SF2">
        <property type="entry name" value="INTEGRIN SUBUNIT BETA 1 BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04968">
        <property type="entry name" value="CHORD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51401">
        <property type="entry name" value="CHORD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CHORD" evidence="6">
        <location>
            <begin position="46"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="CHORD" evidence="6">
        <location>
            <begin position="192"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="CS" evidence="5">
        <location>
            <begin position="260"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="99"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="351"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="132"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005014408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="420" mass="45911" checksum="E205F71F51C00F39" modified="2022-01-19" version="1">MRAVQPCAVLLPSSELISFLPSSIKHSEGTSSVTDLCSTSLLCRGCLQPALRAFLSSDSCLYHPGVPIFHDALKGWSCCKKRTTDFSEFLSIKGCMKGFHSKEKPPEPSQEETSDKPKAKPMAEIIVQGPKSAEKMQRERPSSDEPRQLLPIKVSRSLEHALEKLSLSPNNKEPKGDCAGSDELMAITGTTCKNAACKAIYQGPESNTEVCTFHPGVPVFHEGMKYWSCCGIRTTDFSAFLEQPGCSTGRHCWMGKDKKAVSCRQDWHQTGNQVVVTIYGKNPLPTLSSVKANRTVLEVHVIFEGNKIFQAELDLWGVIDTEKSFVSMVPTKVEITLCKSSPGAWARLEQPQSKACAQGQPDPAAVSTEEPEDESDDSLSWSEDEEDEELGAARGLCGALCESGRSPERPVALPADRDEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YBX6</accession>
    <name>A0A8C2YBX6_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Fibrillin-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">FBN2</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-2-containing microfibrils regulate the early process of elastic fiber assembly. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Hormone secreted by trophoblasts that promotes trophoblast invasiveness. Has glucogenic activity: is able to increase plasma glucose levels.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Interacts with BMP2, BMP4, BMP7, BMP10 and GDF5. Interacts with MFAP2 and MFAP5. Interacts with ADAMTSL5. Interacts with MFAP4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fibrillin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015705146.1">
        <property type="nucleotide sequence ID" value="XM_015849660.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005021799.1">
        <property type="protein sequence ID" value="ENSCJPP00005015355.1"/>
        <property type="gene ID" value="ENSCJPG00005012752.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107306465"/>
    <dbReference type="KEGG" id="cjo:107306465"/>
    <dbReference type="CTD" id="2201"/>
    <dbReference type="GeneTree" id="ENSGT00950000183158"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome Z"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001527">
        <property type="term" value="C:microfibril"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060346">
        <property type="term" value="P:bone trabecula formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043010">
        <property type="term" value="P:camera-type eye development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048048">
        <property type="term" value="P:embryonic eye morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030326">
        <property type="term" value="P:embryonic limb morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030501">
        <property type="term" value="P:positive regulation of bone mineralization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045669">
        <property type="term" value="P:positive regulation of osteoblast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035583">
        <property type="term" value="P:sequestering of TGFbeta in extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="27"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000005">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000023">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000038">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000049">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000058">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000071">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000086">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000087">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000097">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000107">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000131">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000141">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000149">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000159">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000171">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000196">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000264">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.290.10:FF:000005">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.290.10:FF:000006">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.290.10:FF:000007">
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        </source>
    </evidence>
    <sequence length="2902" mass="313226" checksum="97742731B71A892E" modified="2022-01-19" version="1">MGRRRWLCLQPCFLWLSCLALYAHGAAGQQKPPPRVRPAGGAGGIYPAAAAAHREEGAGSAAAAGRVRRRGQQEALRGPNVCGSRFHSYCCPGWKTLPGGNQCIVPICRNSCGDGFCSRPNMCTCASGQISPTCGPKSTQQCSIRCMNGGTCADDRCQCQKGYIGVYCGQPVCEKGCQNGGRCIGPNRCACVYGFTGPQCERDYRTGPCFTQVNNQMCQGQLTGIVCTKTLCCATIGRAWGHPCEMCPAQPQPCRRGFIPNIRTGACQDVDECQAIPGVCQGGNCINTVGSYECKCPAGHRQNEATQKCDDIDECIIIPGVCEGGECSNTVGSYFCLCPRGYVSSTDGSRCIDQRASTCFANLVNGRCAQELPGRFTKRQCCCESGRCWAAGSVPEMCPIRGSDEHRRLCLDGVPAGGGSRGGGGTGGNGFLPGGNGNGYSPGGAGFIPIPGSNGFSPGVGGAGVGTGGQTATGNGPIITGLTILNQTIDICKHHPNLCLNGRCIPTISSYRCECNMGYKQDANGDCIDVDECTSNPCSNGDCVNTPGSYYCKCHEGFQSTPTKQACIDIDECIQNGVLCKNGRCVNTDGSFQCICNAGFELTTDGKNCVDHDECTTTNMCLNGMCINEDGSFKCICKPGFVLAPNGRYCTDIDECQTSGICMNGHCINTEGSFRCECPPGLAVGVDGRVCVDTHMRSTCYGGIKKGSCIRPFPGAVTKSECCCANPDYGFGEPCHPCPAKNSAEFHGLCSSGVGITVDGRDINECALDPDICSNGICENLRGSYRCNCNSGYEPDPSGRNCVDIDECSVNGLLCDNGLCRNTPGSYSCTCPKGYVFSTETDTCEDINECESSPCVNGACRNNLGSFSCECSPGSKLDSTGLICIDSLKGTCWLNIQDSRCEVNINGATLKSECCATLGAAWGSPCERCELDTACSRGFARVKGVTCEDVNECDVFPGVCPNGRCVNSRGSFHCECPEGLTLDGTGRVCLDIRMEQCYLKWDEDECIQSVPGKFRMDACCCAVGAAWGSDCEECPKPGTKEYEALCPRGPGFSNRGDILTGRPFYKDINECKVFPGMCMNGKCRNTIGSFKCRCNSGFALDMEERNCTDIDECRISPDLCGSGTCVNTPGSFECECFDGYESGFMMMKNCMDIDECERNPLLCRGGMCVNTEGSFQCDCPAGHELSPSQEECIDVNECSLSDNLCRNGNCVNMVGTYQCSCNSGYQATADRQGCVDIDECMIMNGGCDTHCTNSEGSYECSCSDGYALMPDVRTCADIDECENNPDICDGGQCSNIPGEYRCLCYDGFMASMDMKTCIDVNECDLNSNICMFGECENTKGSFICHCQLGYSVKKGTTGCTDVDECEISAHNCDMHASCVNVPGSFKCTCREGWFGNGIKCIDLDECSNGTHQCSVNAQCVNTPGSYRCACAEGFTGDGFSCSDVDECAENINLCENGQCLNVPGAYRCECEMGFTPASDSKSCQDIDECSFQNICVFGTCNNLPGMFHCICDDGYELDRTGGNCTDIDECADPINCVNGLCVNTPGRYECNCPPDFQLNPTGVGCVDNRVGNCYLKYGPRGDGSLSCNTEIGVGVSRSSCCCSLGKAWGNPCETCPSVNSTEYNTLCPGGEGFRPNPITIILEDIDECQELPGLCQGGNCINTFGSFQCECPKGYYLSEETRICEDIDECVAHPGVCGPGTCYNTLGNYTCICPPEYMQVNGGHNCMDMRKSFCYRSYNGTTCENELPFNVTKRMCCCTYNVGKAWNKPCEPCPTPGTAEFKNICGNIPGFTFDIHTGKAVDIDECKEIPGICANGVCINQIGSFRCECPTGFSYNDLLLVCEDIDECSNGDNLCQRNADCINSPGSYRCECAAGFKLSPNGACVDRNECLEIPNVCSHGLCVDMQGSYQCICHNGFKASQDQTMCMDVDECERHPCGNGTCKNTVGSYNCLCYPGFELTHNNDCMDVDECSSFFGQVCRNGRCFNEIGSFKCLCNEGYELTLDGKNCIDTNECVALPGSCSPGTCQNLEGSFRCICPPGYEVKSESCIDINECNEDPNICLFGSCTNTPGGFQCICPTGFVLSDNGRRCFDTRQSFCFTNFENGKCSVPKAFNTTKAKCCCSKMPGEGWGDPCELCPKEEEVAFQDLCPYGHGTIPGIDDTREDVNECLESPGICSNGHCINTDGSFRCECPMGYNLDFTGVHCIDTDECSIGNPCGNGTCTNVIGSFECNCHEGFEPGPMMNCEDINECAQNPLLCAFRCINTYGFYECTCPVGYELREDQKMCKDLDECAEGLHDCESRGMMCKNLIGTFMCICPPGMTRRPDGEGCTDENECRTKPGICENGRCMNVIGSYRCECNEGFLSSPSGIECLDNRQGFCFAEVLQTMCQMASSSRNLVTKSECCCDGGRGWGNQCELCPLPGTTQYKKLCPHGPGYTTDGRDIDECKVMPNLCRHGQCINTMGSFRCFCKVGYTTDISSTSCVDLDECSQSPKPCNFICKNSEGSYQCSCPRGYILQEDGKTCKDLDECQTKQHNCQFLCVNTLGGFTCKCPPGFTQHHTACIDNNECGSQPSLCGSKGICQNTPGSFTCECQRGFSLDSTGLNCEDVDECDGNHRCQHGCQNILGGYRCGCPQGYIQHYQWNQCVDENECSNPNTCGSASCYNTLGSYKCACPSGFSYDQFSSACHDVNECSSAKNPCNYGCSNTEGGYLCGCPPGYYRVGQGHCVSGMGFNKGQYLPVDGDADEENALSPEACYECKINGYPKKDNRKKRSLNETIEQVSLESLDMDSPLKMRVNISRLDNKEHILELMPAIEPLNNHVRYVISHGNDDGIFRIHQQDGLSYLHTAKKKSVPGTYTLEITSIPLYKKKELKKLEDSNEGNYLLGELGEALRMRLWLELY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YC17</accession>
    <name>A0A8C2YC17_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">IQ motif and Sec7 domain ArfGEF 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">IQSEC1</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BRAG family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015730176.1">
        <property type="nucleotide sequence ID" value="XM_015874690.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YC17"/>
    <dbReference type="Ensembl" id="ENSCJPT00005022051.1">
        <property type="protein sequence ID" value="ENSCJPP00005015571.1"/>
        <property type="gene ID" value="ENSCJPG00005012881.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107319669"/>
    <dbReference type="CTD" id="9922"/>
    <dbReference type="GeneTree" id="ENSGT00940000156915"/>
    <dbReference type="OrthoDB" id="430364at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13318">
        <property type="entry name" value="PH_IQSEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1000.11:FF:000001">
        <property type="entry name" value="IQ motif and SEC7 domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.20:FF:000001">
        <property type="entry name" value="IQ motif and SEC7 domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000004">
        <property type="entry name" value="IQ motif and SEC7 domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033742">
        <property type="entry name" value="IQSEC_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF327">
        <property type="entry name" value="IQ MOTIF AND SEC7 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16453">
        <property type="entry name" value="IQ_SEC7_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="8">
        <location>
            <begin position="638"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="131"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="434"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="499"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="993"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1039"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="11"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="440"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="552"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="592"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1007"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1061"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1100"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1136"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1178"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1206"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1226"/>
            <end position="1235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1271" mass="143672" checksum="1B770C2F246CABCB" modified="2022-01-19" version="1">MESPAENPSKAAEYLKELNKIIETQQELLEKQKRRIDELEQQVAKLYHENACLQDEHHRHLATCRLQQGVPPAYPGVLSAIQENAKHEKSEGDSSRSVRSLNTLHQFCCPAPLYHTQLAVPATHSEYRTSLETGSSISTDPLSVEGEAPSSETGTSLDSPSAYHQGPITHSSAISPDHYDHSAYGLYSVSPGQQRTRRPKLQHSTSILRKQAEEEAIKRSRSLSESYELSSDLQDKQVEMLERKYGGRLITRHAARTIQTAFRQYQMNKNFERLRSSMSENRMSRRIVLSNMRMQFSFEGPEKVHSSYFEGKQVSVTNDGSKLGSLVQSECSDLGESATMKSPATSTDFADAITELEDAFSRQVKSLAESIDDALNCRSLHSDEVQTPDQVRSREMERDSCAQTKPIHNVDHRKLDEMTASYSDVTLYIDEEELSPPLPLSQSVDRPSSTESDLRLRSVNSSQEYWSMTHKDDKIDTDTSCRSTPSLECQEQRIRMDHLPLLTIEPPSDSSVDLSDRSERGSLKRQNAYDRGITSQQGSPKHIPHSIPAKIISREEQEARHRPRPIDSHLAINGTANRQSKSESDYSDGDNDSINSTSNSNDTINCSSESSSRDSLREQTLSKQTYHKETRNSWDSPAFSNDIIRKRHYRIGLNLFNKKPEKGVQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCICNPGVVRQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFVKNLRGVDDGEDIPREMLIGIYERIRKRELKTNEDHVSQVQKVEKLIVGKKPIGSLHHGLGCVLSLPHRRLVCYCRLFEVPDPNKPQKLGLHQREIFLFNDLLVVTKIFQKKKNSVTYSFRQSFSLYGMQVLLFENQYYPNGIRLTSAVPGADIKVLINFNAPNPQDRKKFTDDLRESIAEVQEMEKHRIESELEKQKGVVRPSMSQCSSLKKDSGNGTLNRACLDDSYATGEGLKRSALSSSLRDLSEAGKRGRRSSAGSLDSNMEGSIISSPHMRRRATSTRECPSRPHQTMPNSSSLLGSLFGSKRGKPPSQGHPPSGSSQQPPHPPVIPHQQHSQHPSAMHHAGPAEGQTQAQVHSHHSQYCHMQQNPPPYHHHHHYHPPQHIQHPHQYHQHVPHSQHVAHSQHTPYMQHSHAQHTHSPHPPLPPPHPGHSSHPQHTQHHHGPPPPPSTSASTKPKHSGISTIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YC27</accession>
    <name>A0A8C2YC27_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Multiple C2 and transmembrane domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">MCTP1</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasmic vesicle</location>
            <location evidence="3">Secretory vesicle</location>
            <location evidence="3">Synaptic vesicle membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Recycling endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MCTP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2YC27"/>
    <dbReference type="Ensembl" id="ENSCJPT00005021838.1">
        <property type="protein sequence ID" value="ENSCJPP00005015392.1"/>
        <property type="gene ID" value="ENSCJPG00005012764.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156031"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome Z"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046928">
        <property type="term" value="P:regulation of neurotransmitter secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04042">
        <property type="entry name" value="C2A_MCTP_PRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08376">
        <property type="entry name" value="C2B_MCTP_PRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08377">
        <property type="entry name" value="C2C_MCTP_PRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000050">
        <property type="entry name" value="Multiple C2 and transmembrane domain containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000068">
        <property type="entry name" value="multiple C2 and transmembrane domain-containing protein 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000019">
        <property type="entry name" value="Multiple C2 and transmembrane domain-containing protein 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013583">
        <property type="entry name" value="MCTP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45911">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45911:SF3">
        <property type="entry name" value="DYSFERLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08372">
        <property type="entry name" value="PRT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00360">
        <property type="entry name" value="C2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="14" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0770">Synapse</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="711"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="818"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="18">
        <location>
            <begin position="206"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="18">
        <location>
            <begin position="369"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="18">
        <location>
            <begin position="508"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="118"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="145"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00074931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="902" mass="102133" checksum="0369504F52E635E2" modified="2022-01-19" version="1">MEPGKEPRAAGEKPGEPEPAVSFQARLWKNLQLGSKGRSGGGGRAAADRRTAEPPAPPAGGKADPLPPARWAGFRRRRQVLDRVFSSSQPNLCCSAAEPLEPGGESGFALRRLREHLLPQGKGPPPARREGPAAAPPPPAGPKAGGEEGHRAGKEGRRPGAHLSHQKSSSLPSTACLEQLLHGSPTAGRRTEHRAEELLYSFPLQKTSSVGPSNADFPSGDPGMYQLDITLKRGQNLAARDRGGTSDPYVKFKLGGKEVFRSKTIHKNLNPIWEEKTCILIDNPREPLYIKVFDYDFGLQDDFIGSAFLNLASLELNRQTDVTLSLKDPHYPDHDLGNILLSVLLSPREEQREVTMLMRKSWKRSSKFQTQSLRLSDLHRKSQLWRGIVSITLIEGRELKAMDANGLSDPYVKFRLGHQKYKSKIMPKTLNPQWREQFDFHLYEERGGIIDITVWDKDAGKKDDFIGRCQVDLSTLSKEQTHKLEMPLEEGEGCLVLLVTLTASAAVTISDLSVNSLEDPKEREEILKRYVWSSLLPFVYVKMLTIKGKSDPFCVVELNNDRLLTHTVYKNLNPEWNKIFTFNIKDIHSVLEVTVYDEDRDRSADFLGKVAIPLLSIQNGEQKAYVLKNKQLTGPTKGVIYLEIDVIFNAVKASIRTLMPKEQKYIEEENRLSKQLLLRNFIRMKRCVMVLINAAYYINSCFDWDSPPRSLAAFLLFLFVVWNFELYMIPLALLLLLAWNYFLIISGKDNRQHDTVVEDMLEDEEEEDDRDDKDSEKKGFMDKLYAIQEVCVSVQNILDEVASFGERIKNTFNWTVPFLSWLAIVALCVFTVILYLIPLRYIVLVWGINKFTKKLRSPYAIDNNELLDFLSRVPSDVQVVQYHELKQDPSHSPSKRKKNNPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YDG9</accession>
    <name>A0A8C2YDG9_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sushi domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2YDG9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005025787.1">
        <property type="protein sequence ID" value="ENSCJPP00005018549.1"/>
        <property type="gene ID" value="ENSCJPG00005015098.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000164219"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.70.10:FF:000014">
        <property type="entry name" value="Membrane cofactor protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050350">
        <property type="entry name" value="Compl-Cell_Adhes-Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19325:SF570">
        <property type="entry name" value="COMPLEMENT COMPONENT 4 BINDING PROTEIN, MEMBRANE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19325">
        <property type="entry name" value="COMPLEMENT COMPONENT-RELATED SUSHI DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1 6" id="KW-0768">Sushi</keyword>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="70"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="181"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="183"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005018549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="248" mass="26453" checksum="0B12BDA76CAC556F" modified="2022-01-19" version="1">MSPCSTGACGPPPLMPHSQPSDIEQLSSFPVGSRVTYLCVHGAVRIPGVLDTVQCLPGSQWSELRDPCGLSCTTPTTLHFAALSEVDEMINFYPVGFTVSYSCRPGYENITENQPSSTCLENLMWSEVPELCQRKSCGPPMAPPAGRTLQPTDFLFGTRVSVLCNEGLSVMLLLAFCHAVITCSSPPRISNGKHDGEGVEKFAYNSTVSYSCDSGFQLIGNVSIRCTRAGNAGGGWSGAVPQCKGDFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YE21</accession>
    <name>A0A8C2YE21_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sedoheptulokinase</fullName>
            <ecNumber evidence="10">2.7.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Carbohydrate kinase-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">SHPK</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Acts as a modulator of macrophage activation through control of glucose metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>sedoheptulose + ATP = D-sedoheptulose 7-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23844"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16802"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.14" evidence="10"/>
    <dbReference type="RefSeq" id="XP_015735870.1">
        <property type="nucleotide sequence ID" value="XM_015880384.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YE21"/>
    <dbReference type="Ensembl" id="ENSCJPT00005027139.1">
        <property type="protein sequence ID" value="ENSCJPP00005019619.1"/>
        <property type="gene ID" value="ENSCJPG00005015889.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107322397"/>
    <dbReference type="CTD" id="23729"/>
    <dbReference type="GeneTree" id="ENSGT01000000214434"/>
    <dbReference type="OrthoDB" id="10264182at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050277">
        <property type="term" value="F:sedoheptulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035963">
        <property type="term" value="P:cellular response to interleukin-13"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071353">
        <property type="term" value="P:cellular response to interleukin-4"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071222">
        <property type="term" value="P:cellular response to lipopolysaccharide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050727">
        <property type="term" value="P:regulation of inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043030">
        <property type="term" value="P:regulation of macrophage activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd07777">
        <property type="entry name" value="ASKHA_NBD_FGGY_SHK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000111">
        <property type="entry name" value="Sedoheptulokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000132">
        <property type="entry name" value="Sedoheptulokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196:SF67">
        <property type="entry name" value="SEDOHEPTULOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="13">
        <location>
            <begin position="10"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="13">
        <location>
            <begin position="142"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00052736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00057196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00066341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00069425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00076706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005019619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="470" mass="50809" checksum="1483503825FAAE4D" modified="2022-01-19" version="1">MEGGPDSACVLGIDLGTTSVKVALVLRTEQGLVVAESCSRETQAYTSSVEAGLQGMEQDSRRIIRALNECLAALPQQQLQRVSHIGISGQMHGIVFWKRDQGCKWTEGATGPVFEPDKVSHLVTWQDGRCSPAFLSSLPLPQSHISLATGFGCATIYWYLKKSPDFLKSYDAAGTIHDYVVAMLCDLKKPLMSVQNAASWGYFNSRNKSWNTDILKKSGFPVHLLPEVGDPGSIAGRTISAWHGIPKGTKVGIALGDFQCSVYSCLTERTDAVLNISTSAQLTISMPSGFQPPETPDPSSAVTYFPYFDGDYLAVAASLNGGNVLATFVDMVAQWTAELGFQIQESAIYAKIIKAALGQNDSHLSVHPTIFGERHTPEQLASVTSIAASELSLGHVTRALCRGVIENLCSMLPVQRLMETGVRRILGSGSALARNEVLRQEVERILPFPVVYGKDVDAAVGAAMVMFHRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YEX3</accession>
    <name>A0A8C2YEX3_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">RAB39B, member RAS onco family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">RAB39B</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Autolysosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Cytoplasmic vesicle membrane</location>
            <topology evidence="12">Lipid-anchor</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015716058.1">
        <property type="nucleotide sequence ID" value="XM_015860572.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YEX3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005029566.1">
        <property type="protein sequence ID" value="ENSCJPP00005021540.1"/>
        <property type="gene ID" value="ENSCJPG00005017230.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107312827"/>
    <dbReference type="KEGG" id="cjo:107312827"/>
    <dbReference type="CTD" id="116442"/>
    <dbReference type="GeneTree" id="ENSGT00940000158132"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120281">
        <property type="term" value="C:autolysosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031489">
        <property type="term" value="F:myosin V binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032482">
        <property type="term" value="P:Rab protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd04111">
        <property type="entry name" value="Rab39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000358">
        <property type="entry name" value="RAB39B, member RAS oncogene family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041818">
        <property type="entry name" value="Rab39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00060425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005021540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="213" mass="24589" checksum="F5B370A8FBC64ED1" modified="2022-01-19" version="1">MEAIWLYQFRLIVIGDSTVGKSCLLHRFTEGRFAQISDPTVGVDFFSRLVEIEPGKRIKLQIWDTAGQERFRSITRAYYRNSVGGLLLFDITNRRSFQNVHEWLEETKVHVQPYQIVFVLVGHKCDLDTQRQVTRHEAEKLAAAYGMKYIETSARDAINVEKAFTDLTRDIYELVKRGEISIQEGWEGVKSGFVPNVVHSSEEVVKSDRRCLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YF55</accession>
    <name>A0A8C2YF55_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">TIMM10</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="function">
        <text evidence="14">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Mitochondrion inner membrane</location>
            <topology evidence="1 14">Peripheral membrane protein</topology>
            <orientation evidence="1 14">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="14">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the small Tim family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015719149.1">
        <property type="nucleotide sequence ID" value="XM_015863663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YF55"/>
    <dbReference type="SMR" id="A0A8C2YF55"/>
    <dbReference type="Ensembl" id="ENSCJPT00005030211.1">
        <property type="protein sequence ID" value="ENSCJPP00005022032.1"/>
        <property type="gene ID" value="ENSCJPG00005017603.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107314454"/>
    <dbReference type="KEGG" id="cjo:107314454"/>
    <dbReference type="CTD" id="26519"/>
    <dbReference type="GeneTree" id="ENSGT00390000003068"/>
    <dbReference type="OrthoDB" id="274922at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042719">
        <property type="term" value="C:mitochondrial intermembrane space chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042721">
        <property type="term" value="C:TIM22 mitochondrial import inner membrane insertion complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.810:FF:000002">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11038">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11038:SF16">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 14" id="KW-0143">Chaperone</keyword>
    <keyword evidence="11 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 14" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7 14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Tim10-like" evidence="15">
        <location>
            <begin position="7"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005022032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="90" mass="10271" checksum="A7B350793C6EE009" modified="2022-01-19" version="1">MDPLRAQQLAAELEVDMMADMYNRMTQACHLKCVPPHYKEAELSKGESVCLDRCVAKYLDVHERMGKKLTELSLQDEELLKRMQQGTGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YF80</accession>
    <name>A0A8C2YF80_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Metaxin-2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Mitochondrial outer membrane import complex protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">MTX2</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in transport of proteins into the mitochondrion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with MTX1/metaxin-1. Associates with the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MICOS10/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOOL/MIC27, IMMT/MIC60, APOO/MIC23/MIC26 and QIL1/MIC13. This complex was also known under the names MINOS or MitOS complex. The MICOS complex associates with mitochondrial outer membrane proteins SAMM50, MTX1 and MTX2 (together described as components of the mitochondrial outer membrane sorting assembly machinery (SAM) complex) and DNAJC11, mitochondrial inner membrane protein TMEM11 and with HSPA9. The MICOS and SAM complexes together with DNAJC11 are part of a large protein complex spanning both membranes termed the mitochondrial intermembrane space bridging (MIB) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metaxin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2YF80"/>
    <dbReference type="Ensembl" id="ENSCJPT00005030453.1">
        <property type="protein sequence ID" value="ENSCJPP00005022188.1"/>
        <property type="gene ID" value="ENSCJPG00005017723.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182919"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001401">
        <property type="term" value="C:SAM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006839">
        <property type="term" value="P:mitochondrial transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03211">
        <property type="entry name" value="GST_C_Metaxin2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000033">
        <property type="entry name" value="metaxin-2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033468">
        <property type="entry name" value="Metaxin_GST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050931">
        <property type="entry name" value="Mito_Protein_Transport_Metaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019564">
        <property type="entry name" value="Sam37/metaxin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289">
        <property type="entry name" value="METAXIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289:SF38">
        <property type="entry name" value="METAXIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17171">
        <property type="entry name" value="GST_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10568">
        <property type="entry name" value="Tom37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Mitochondrial outer membrane transport complex Sam37/metaxin N-terminal" evidence="14">
        <location>
            <begin position="121"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Metaxin glutathione S-transferase" evidence="15">
        <location>
            <begin position="211"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00058396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00063864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00072180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00076977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF10568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005022188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="300" mass="34049" checksum="98795BDDDA29A28A" modified="2022-01-19" version="1">MSLVAEAFMNQLAAAEPWPENAALYQQLKEDQILLSDNAASLAVQEDKMASLSYIVWRAAAAELEMSFLSQEGRAKVSELCASRPWQSSTDCFFQPSCKCAICRFGWFAGPMLSTCPHLGHSLSDGLDEVQKAEMKAYMELVNNMLLTAELYLQWCDDVTVEEITHPRYGSPYPWPLNRILSYQKQWEIRRKMKAIGWAGKSLEQVLEDVDQCCQALSQRLGTQPYFFNKQPTELDALVFGHLFTILTTQLITDELSEKVKNYGNLTAFCRRIEQQYFEGHDKDNSATAPARSAKRSSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YFP6</accession>
    <name>A0A8C2YFP6_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">LIM domain binding 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LDB2</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Binds to the LIM domain of a wide variety of LIM domain-containing transcription factors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the LDB family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2YFP6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005031775.1">
        <property type="protein sequence ID" value="ENSCJPP00005023160.1"/>
        <property type="gene ID" value="ENSCJPG00005018404.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000005639"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030274">
        <property type="term" value="F:LIM domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000063">
        <property type="entry name" value="LIM domain-binding protein 2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041363">
        <property type="entry name" value="LID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029005">
        <property type="entry name" value="LIM-bd/SEUSS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10378">
        <property type="entry name" value="LIM DOMAIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17916">
        <property type="entry name" value="LID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01803">
        <property type="entry name" value="LIM_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51957">
        <property type="entry name" value="LID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LIM interaction" evidence="7">
        <location>
            <begin position="492"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="438"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="521"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="457"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="535"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00056808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005023160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="567" mass="63504" checksum="B19FBADA381140F8" modified="2022-01-19" version="1">MPHPSAPSRPGDSGAPRASTHPAAPRRSRRLWVSGRPRAPLGAPRAERPRAGSGSVKTSYMLTSPAAGLLRGPGGQTPSGAPHLGGAARGKCRRRGAPTARTGNDPLGSRRFKAERRCPRPPAPLAHRRPPRRAPRPPRRRPRRGLAGSSPAAPRPHVCVCACRYFVPRRARSPCALHGGWRYSVSLEPPRAGKMSSAPHDPFYSSPFGPFYRRHTPYMVQPEYRIYEMNKRLQARSEDSDNLWWDAFATEFFEDDATLTLSFCLEDGPKRYTIGRTLIPRYFSTVFEGGVTDLYYILKHSKESYHNSSITVDCDQCTMVTQHGKPMFTKVCTEGRLILEFTFDDLMRIKTWHFTIRQYRELVPRSILAMHAQDPQVLEQLSKNITRMGLTNFTLNYLRLCVILEPMQELMSRHKTYNLSPRDCLKTCLFQKWQRMVAPPAEPTRQPTTKRRKRKNSTSSTSNSSAGNNANSTNSKKKSAAANLSLSSQVPDVMVVGEPTLMGGEFGDEDERLITRLENTQYDAANGMDDEEDFNNSPALGNNSPWNSKPPANQETKSENPTPQASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YFX5</accession>
    <name>A0A8C2YFX5_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Retinol dehydrogenase 3-like</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2YFX5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005032308.1">
        <property type="protein sequence ID" value="ENSCJPP00005023583.1"/>
        <property type="gene ID" value="ENSCJPG00005018686.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000164857"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313:SF47">
        <property type="entry name" value="RETINOL DEHYDROGENASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005023583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="327" mass="36544" checksum="827F3B7C660CABEC" modified="2025-10-08" version="2">MHIVILASILSLIIYWLIRDRHRVRDLSEKYVFITGCDTTLGNALAKWLDKRGFCVIAACANEKEGQELLSCSSLSLKTVDLDLADSSSISRAVLFVTEETAGKGLFGLVNAAEGATPAAPTDWLRIDDFHSVLDVNLLGLIEITLKLLPLLKKAEGRVVNLINAKGFMAFVGGGYNLSKWGMESFSDILRRDIQHFGVKVSIVGHSFFNTKVNSSIMERDLLRLWNRLPNDIRDSYGEKYFSEYRKAQRSSVKRLCNSDISKVIKCMEHALLAKYPRTRYGAGWDAKFFWLFLYYAPSCLSDMLFHMMLPAPAASGSSVPGALINI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1990-11-01" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>P18638</accession>
    <name>H5_COTJA</name>
    <protein>
        <recommendedName>
            <fullName>Histone H5</fullName>
        </recommendedName>
    </protein>
    <organism>
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1976" name="Biochem. Biophys. Res. Commun." volume="71" first="196" last="202">
            <title>Species variability of N-terminal sequence of avian erythrocyte-specific histone H5.</title>
            <authorList>
                <person name="Seligy V."/>
                <person name="Roy C."/>
                <person name="Dove M."/>
                <person name="Yaguchi M."/>
            </authorList>
            <dbReference type="PubMed" id="962913"/>
            <dbReference type="DOI" id="10.1016/0006-291X(76)90268-0"/>
        </citation>
        <scope>PROTEIN SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text>Histone H5 performs the same function as H1, being necessary for the condensation of nucleosome chains into higher order structures, and replaces histone H1 in certain cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location>Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="tissue specificity">
        <text>Erythroid cells.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the histone H1/H5 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="P18638"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0158">Chromosome</keyword>
    <keyword id="KW-0903">Direct protein sequencing</keyword>
    <keyword id="KW-0226">DNA condensation</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000196007" description="Histone H5">
        <location>
            <begin position="1"/>
            <end position="16" status="greater than"/>
        </location>
    </feature>
    <feature type="non-terminal residue">
        <location>
            <position position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="16" mass="1665" checksum="DB528219B3074D3C" modified="1990-11-01" version="1" fragment="single">TESLVLSPAPAKPKRA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-07-15" modified="2025-02-05" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>P81061</accession>
    <name>CYT_COTJA</name>
    <protein>
        <recommendedName>
            <fullName>Cystatin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Egg-white cystatin</fullName>
        </alternativeName>
    </protein>
    <organism>
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1997" name="FEBS Lett." volume="412" first="551" last="558">
            <title>Quail cystatin: isolation and characterisation of a new member of the cystatin family and its hypothetical interaction with cathepsin B.</title>
            <authorList>
                <person name="Gerhartz B."/>
                <person name="Engh R.A."/>
                <person name="Mentele R."/>
                <person name="Eckerskorn C."/>
                <person name="Torquato R."/>
                <person name="Wittman J."/>
                <person name="Kolb H.J."/>
                <person name="Machleidt W."/>
                <person name="Fritz H."/>
                <person name="Auerswald E.A."/>
            </authorList>
            <dbReference type="PubMed" id="9276465"/>
            <dbReference type="DOI" id="10.1016/S0014-5793(97)00806-5"/>
        </citation>
        <scope>PROTEIN SEQUENCE</scope>
        <scope>PHOSPHORYLATION AT SER-80</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <source>
            <tissue>Egg white</tissue>
        </source>
    </reference>
    <comment type="function">
        <text>This protein binds tightly to and inhibits papain and cathepsin B.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cystatin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="P81061"/>
    <dbReference type="SMR" id="P81061"/>
    <dbReference type="MEROPS" id="I25.011"/>
    <dbReference type="iPTMnet" id="P81061"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031982">
        <property type="term" value="C:vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004869">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00042">
        <property type="entry name" value="CY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.10:FF:000004">
        <property type="entry name" value="Cystatin C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000010">
        <property type="entry name" value="Cystatin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046350">
        <property type="entry name" value="Cystatin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018073">
        <property type="entry name" value="Prot_inh_cystat_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46186">
        <property type="entry name" value="CYSTATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46186:SF2">
        <property type="entry name" value="CYSTATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00031">
        <property type="entry name" value="Cystatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00043">
        <property type="entry name" value="CY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54403">
        <property type="entry name" value="Cystatin/monellin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00287">
        <property type="entry name" value="CYSTATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0903">Direct protein sequencing</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-0646">Protease inhibitor</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0789">Thiol protease inhibitor</keyword>
    <feature type="chain" id="PRO_0000207151" description="Cystatin">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Secondary area of contact">
        <location>
            <begin position="53"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="site" description="Reactive site">
        <location>
            <position position="9"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="1">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <feature type="disulfide bond">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="disulfide bond">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="9276465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="116" mass="13093" checksum="48248621053A2F70" modified="1998-07-15" version="1">SEGRSRLLGAPVPVRENDEGLQRALQFAMAEYNKASNDKYSSRVVRIISAKQQLVSGIKYIMEVEIGRTTCPKSSADLQSCEFHDEPEMAKYTTCNFVVYSIPWLNQIKLLKSSCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SMX5</accession>
    <name>A0A8C2SMX5_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Methylsterol monooxygenase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MSMO1</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015716376.1">
        <property type="nucleotide sequence ID" value="XM_015860890.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SMX5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005001135.1">
        <property type="protein sequence ID" value="ENSCJPP00005000638.1"/>
        <property type="gene ID" value="ENSCJPG00005000721.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107313018"/>
    <dbReference type="KEGG" id="cjo:107313018"/>
    <dbReference type="CTD" id="6307"/>
    <dbReference type="GeneTree" id="ENSGT00940000158012"/>
    <dbReference type="OrthoDB" id="1658724at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="6">
        <location>
            <begin position="144"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005000638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="296" mass="35456" checksum="8B205C22985DF1AC" modified="2022-01-19" version="1">MATNDSVNILNSAYLAVEYIDSFLPDNPLQQPFKNAWNYMLDNYTKFQIATWGSLLVHEASYFLLCVPGFIFQFIPYMQKYKIQPDKPETWEKQWKCFKTLLFNHFFIQLPLICGTYYFTEFFNIPYEWEKMPRWYVLLAQCFGCAVIEDAWHYFLHRLLHHKRIYKYIHKVHHEFVSPFGMQAEYAHPLETLILGAGFFIGIVVFCNHVVLLWAWVICRLMETIDVHSGYDVPLNPLHLVPFYAGARFHDFHHMNFIGNYASTFTWWDRIFGTDSQFIAYKEKEKKQQLRMKKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SNG8</accession>
    <name>A0A8C2SNG8_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box and leucine rich repeat protein 18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FBXL18</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SNG8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005000482.1">
        <property type="protein sequence ID" value="ENSCJPP00005000236.1"/>
        <property type="gene ID" value="ENSCJPG00005000327.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000015109"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22128">
        <property type="entry name" value="F-box_FBXL18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.50:FF:000159">
        <property type="entry name" value="F-box and leucine rich repeat protein 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001401">
        <property type="entry name" value="F-box and leucine rich repeat protein 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000606">
        <property type="entry name" value="F-box and leucine-rich repeat protein 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047948">
        <property type="entry name" value="FBXL18_F-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045627">
        <property type="entry name" value="FBXL18_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16134:SF19">
        <property type="entry name" value="F-BOX AND LEUCINE-RICH REPEAT PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16134">
        <property type="entry name" value="F-BOX/TPR REPEAT PROTEIN POF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19729">
        <property type="entry name" value="LRR_FBXL18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="19"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005000236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="711" mass="79322" checksum="BAB53603FC841E35" modified="2022-01-19" version="1">MSCCAQDPVSGENEEESNGINLMEFSDEILLHILSYVPCTDLVLNVRKTCRKLATLCLDKSLTHTVLLQKDYKVNKDKVKQLMRDIGKEIYQLNMAGCYWLPSSTTDHVTRCKNLVKLNLSGCRITSLRLSKMLSMLQHLRSLAIDVNPGFDASQLSSECKATLSRVSELKQTLYTPSYGVVPCCTSLEKLLLYFEILDRSREGLMLSGQLMVGESNVPHYQNLRVFYARLAPGYVNQEVVRLYLAVLSDRTPENLHAFLISAPGSFAETGATKNLLDSMARNVRLDALQLPKAWLNGSGLLQHLKFNNPFYFSFSRCTLSGGHLIQRVINGGKDLKSLTSLNLSGCVHCLAPESLFRRAEDDIDSSILESLVVSCCNLRHLNLSAAHHHSSESIGNHLCQLLSRLKHLLSLALPVCSITDVAVSTEKPPTQPNATPQTFGKKTRVGVQTYQRNSADQTCQKLESSVFWTLMRSLRFLETLEIIGSSFSSAMPRNEPAIRNSLPPCVRAQSVGDSEVAAISQLTYLQSLTLAQLPNIVTGSGLVSIGLQCQHLRTLSLANLGMMGKMVYMSALMDMLKHCRCLRDLRLEQPYFSAGSQFFQALSHCSSLQRLCIVSRSGTLQSDAVMSFMANCLEVIMCHMFMGESLTVCRNLQQSIVRSFQADRPALNVVIFPLLHEDLTEVIRDVPMRHLDEITLFKSRVAEEPPNLWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SNZ2</accession>
    <name>A0A8C2SNZ2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Guanine nucleotide-binding protein subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">GNG4</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">G proteins are composed of 3 units; alpha, beta and gamma.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Lipid-anchor</topology>
            <orientation evidence="1 9">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the G protein gamma family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015713319.1">
        <property type="nucleotide sequence ID" value="XM_015857833.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015713320.1">
        <property type="nucleotide sequence ID" value="XM_015857834.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015713321.1">
        <property type="nucleotide sequence ID" value="XM_015857835.2"/>
    </dbReference>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
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        <source>
            <dbReference type="PROSITE" id="PS50058"/>
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        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005000702.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
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    </evidence>
    <sequence length="74" mass="8287" checksum="ACF5F25644D4157A" modified="2022-01-19" version="1">MKELTSNSTTNISQARKAVEQLKMEAYMDRMKVSKAAADLLAYCDAHIGEDPLIIPVPASENPFREKKLFCTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SPU9</accession>
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        <submittedName>
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        <name evidence="5" type="primary">ANKRD46</name>
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        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
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            <taxon>Theropoda</taxon>
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            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
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        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39"/>
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    </dbReference>
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        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
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    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
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        <location>
            <begin position="11"/>
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        </location>
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        <location>
            <begin position="44"/>
            <end position="76"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005000788.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="228" mass="25266" checksum="15DF578B46496FBD" modified="2022-01-19" version="1">MSYVFVNDSSQTNVPLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLATDYQGNTALHLCGHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLLESLEEQEVKGFNRGAHSKLETMQTAESESAMESHSLLNPNLQQGEGVLSSFRTTWQEFVEDLGFWRVLLLIIVIALLSLGIAYYVSGVLPFVENQPELVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SQE1</accession>
    <name>A0A8C2SQE1_COTJA</name>
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        <submittedName>
            <fullName evidence="4">Exosome component 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">EXOSC4</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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                <consortium name="Ensembl"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
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    <reference evidence="4" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNase PH family.</text>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:cytosol"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="C:euchromatin"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="C:nuclear exosome (RNase complex)"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:nucleolus"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="C:nucleoplasm"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0045006">
        <property type="term" value="P:DNA deamination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0071044">
        <property type="term" value="P:histone mRNA catabolic process"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:maturation of 5.8S rRNA"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:U4 snRNA 3'-end processing"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ExoRNase_PH_dom1"/>
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        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
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        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF0">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP41"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="3">
        <location>
            <begin position="21"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="Pfam" id="PF01138"/>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="207" mass="22616" checksum="C2A87ECA123CEAF1" modified="2022-01-19" version="1">MAALELLSDEGYRADGRRAAELRKVRARMGVFAQADGSAYIEQGNTKALAVVYGPHEPRGPRSKALSDRAVLNCQYSMATFSTAERKRRPHGDRKSMEMALHLKQTFEAAIITELYPRSQIDIYVQIPSGGWQQLLRLRERRHVGSDGRRHRAARLRLRRLGGFGRGRGVGRPELHRGGGRGPAGGAGVTAGLWSHGLGADGRAAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SQP0</accession>
    <name>A0A8C2SQP0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UDENN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SQP0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005002344.1">
        <property type="protein sequence ID" value="ENSCJPP00005001398.1"/>
        <property type="gene ID" value="ENSCJPG00005001431.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160472"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032483">
        <property type="term" value="P:regulation of Rab protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.100.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051696">
        <property type="entry name" value="DENN_Domain_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023341">
        <property type="entry name" value="MABP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005113">
        <property type="entry name" value="uDENN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296:SF18">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03456">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00800">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51498">
        <property type="entry name" value="MABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MABP" evidence="4">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="UDENN" evidence="3">
        <location>
            <begin position="133"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="38"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005001398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="345" mass="37666" checksum="8670099EB1395592" modified="2022-01-19" version="1">WAAPVPARRAEPITSWRYRCGSEGRRFPQDFTCIDRTTGGRPAELSNGSGADKTALIRGRDPPRPGVVVLDTTPYSRSANLGSGGPGSPRWFLCYRRAERGHNALGVTELCLVMPSKGESTPHTFSRVPRSLNCGTVRNGSGARNGGGGHRDGLLCRYPEQDAPSFPLPGSVPSFCLPMGAAIEGCAAGTRYPLPVFSTFVLTGASGDKVYGAAIQFHEPFPLSRLSERQRLRLGLLSVVERRPVPGRVVLGTKALCVLSHWPLFDVFRKFLMFLYRYSVSGPHVLPIETHIAHFMHNVPFPSPQRPRILVQMSPYDSLLLCQPVSSPLPLRWGPIMGSGLWGDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SQS7</accession>
    <name>A0A8C2SQS7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP synthase mitochondrial F1 complex assembly factor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ATPAF2</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Plays a role in the assembly of the F1 component of the mitochondrial ATP synthase (ATPase).</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with ATP5F1B; involved in the assembly of the F1 component of the mitochondrial ATP synthase (ATPase). Interacts with FMC1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP12 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015732399.1">
        <property type="nucleotide sequence ID" value="XM_015876913.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SQS7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005004248.1">
        <property type="protein sequence ID" value="ENSCJPP00005002363.1"/>
        <property type="gene ID" value="ENSCJPG00005002547.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107320731"/>
    <dbReference type="KEGG" id="cjo:107320731"/>
    <dbReference type="CTD" id="91647"/>
    <dbReference type="GeneTree" id="ENSGT00390000009492"/>
    <dbReference type="OrthoDB" id="5673at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3580.10:FF:000001">
        <property type="entry name" value="ATP synthase mitochondrial F1 complex assembly factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2180.10:FF:000001">
        <property type="entry name" value="ATP synthase mitochondrial F1 complex assembly factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3580.10">
        <property type="entry name" value="ATP12 ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2180.10">
        <property type="entry name" value="ATP12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011419">
        <property type="entry name" value="ATP12_ATP_synth-F1-assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042272">
        <property type="entry name" value="ATP12_ATP_synth-F1-assembly_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023335">
        <property type="entry name" value="ATP12_ortho_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21013:SF10">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21013">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 2/ATP12 PROTEIN, MITOCHONDRIAL PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07542">
        <property type="entry name" value="ATP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160909">
        <property type="entry name" value="ATP12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00054849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00065339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00072488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005002363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="278" mass="31347" checksum="7F82F50ECCA0C624" modified="2022-01-19" version="1">MCRLLQALGRIPAVAARSRPLCPGGSRTYAPPAERKRFYQNVSISQGEGGFEINLDHRKLKTPQAKLFTVPSEALAIAVATEWDSQKDTIKFYTMHLTTLCNTALDNPTQRNKVQLIRAAVKFLETDTVCYRVEEPVALAELQKKEWDPIVAWAEKRYNVAIGSSTSIMGPNIPASTRDTFISHLASYNMWALQGIEYVITQLKSLILSMGLIDRHITVEKAVLLSRLEEEYQIQRWGNVEWAHDYDLCELRARAAAGTLFVHLCSESSTVKHKLLQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SQV2</accession>
    <name>A0A8C2SQV2_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">EBF transcription factor 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">EBF3</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the COE family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SQV2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005002192.1">
        <property type="protein sequence ID" value="ENSCJPP00005001295.1"/>
        <property type="gene ID" value="ENSCJPG00005001333.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182859"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11606">
        <property type="entry name" value="COE_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.4280:FF:000001">
        <property type="entry name" value="transcription factor COE1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.3180:FF:000001">
        <property type="entry name" value="transcription factor COE1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3180">
        <property type="entry name" value="Transcription factor COE1, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032200">
        <property type="entry name" value="COE_DBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038173">
        <property type="entry name" value="COE_DBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032201">
        <property type="entry name" value="COE_HLH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003523">
        <property type="entry name" value="Transcription_factor_COE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018350">
        <property type="entry name" value="Transcription_factor_COE_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10747">
        <property type="entry name" value="TRANSCRIPTION FACTOR COE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16422">
        <property type="entry name" value="COE1_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16423">
        <property type="entry name" value="COE1_HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00429">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01345">
        <property type="entry name" value="COE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="IPT/TIG" evidence="13">
        <location>
            <begin position="262"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="446"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005001295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="619" mass="67781" checksum="52042799709D823E" modified="2022-01-19" version="1">MFGIQENIPRGGTTMKEEPLGSGMNPVRSWMHTAGVVDANTAAQSGVGLARAHFEKQPPSNLRKSNFFHFVLALYDRQGQPVEIERTAFVDFVEKEKEPNNEKTNNGIHYKLQLLYSNGVRTEQDLYVRLIDSMTKQAIVYEGQDKNPEMCRVLLTHEIMCSRCCDKKSCGNRNETPSDPVIIDRFFLKFFLKCNQNCLKTAGNPRDMRRFQVVVSTTVNVDGHVLAVSDNMFVHNNSKHGRRARRLDPSEGTAPSYLENATPCIKAISPSEGWTTGGATVIIIGDNFFDGEVSYLNWWLITPHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGAPGRFVYTALNEPTIDYGFQRLQKVIPRHPGDPERLPKEVLLKRAADLVEALYGMPHNNQEIILKRAADIAEALYSVPRNHNQIPTLANTPAHTGMMGVNSFSSQLAVNVSETSQANDQGYSRNTSSVSPRGYVPSSTPQQSNYNTVSNSMNGYGNAGMPNLGVPGSPGFLNGSSANSPYGIVPSSPTMAASSVTLPSNCSSTHGIFSFSPANVISAVKQKSAFAPVVRPQASPPPSCTSANGNGLQGEPDLSIFFVLLFGACTKTIGGLCRRKVPCCILWFLMLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SR20</accession>
    <name>A0A8C2SR20_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Spindle and kinetochore associated complex subunit 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">SKA3</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
            <location evidence="2">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SKA3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SR20"/>
    <dbReference type="Ensembl" id="ENSCJPT00005002164.1">
        <property type="protein sequence ID" value="ENSCJPP00005001268.1"/>
        <property type="gene ID" value="ENSCJPG00005001324.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00500000045005"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0170027">
        <property type="term" value="C:SKA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140499">
        <property type="term" value="P:negative regulation of mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031110">
        <property type="term" value="P:regulation of microtubule polymerization or depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd12957">
        <property type="entry name" value="SKA3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1400">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033341">
        <property type="entry name" value="SKA3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48118">
        <property type="entry name" value="SPINDLE AND KINETOCHORE-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48118:SF1">
        <property type="entry name" value="SPINDLE AND KINETOCHORE-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="12" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="105"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="176"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="318"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005001268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="490" mass="54578" checksum="36F1CB7E5E984544" modified="2022-01-19" version="1">MDVSRGFFGKLRSLALTLEKEVKHLERAMNGEDADYEEESPMRVLQDLHSEIRTVKEDASAVLAKSSSEKKEVNDFLKATEILMQRSAEDLAKIREVFEKYGYKPQVEVPTEEQEEEANGDSKTSDQSKSDQEQADDVPPLPACAENPAEPRDPLWNPQLSDFGLSHYAFSRPRRALHGQQHAANASQENAEHKTPPKTQAPCALPKTPKCMLKMDDFECVTPKLEHFGISEHTMCMNEDYTMTLICKTAQSNNSVKTGDREVNVAKMPPMETAVTPEPKTKATDENVPAADYMASPVMPVFCTPCFAPGVKIPSRADSAVSARSPERDKLPLPSHAATPPPPDFEARWLKGGVLEMQEKKITLVTENNATEKQSIEGSIPSAVSSDAYLQHLGNQSPPKIKQYDHLLSTPPPPEITRIPDDVLQILSKYNHKVDSSVSKKVETKAGDAARFGSDFSAYCSKENRYDQMFHIWLRNWILIIIIESQNGQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SR32</accession>
    <name>A0A8C2SR32_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Runt-related transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">RUNX2</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="13">Interacts with DDX5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SR32"/>
    <dbReference type="Ensembl" id="ENSCJPT00005004569.1">
        <property type="protein sequence ID" value="ENSCJPP00005002483.1"/>
        <property type="gene ID" value="ENSCJPG00005002743.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160171"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043425">
        <property type="term" value="F:bHLH transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="entry name" value="AML1_Runt"/>
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        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
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        <property type="entry name" value="RUNT-RELATED TRANSCRIPTION FACTOR 2"/>
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    <keyword evidence="7" id="KW-0221">Differentiation</keyword>
    <keyword evidence="10 14" id="KW-0238">DNA-binding</keyword>
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    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
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    <sequence length="472" mass="51690" checksum="EABBDD9A456495E8" modified="2022-01-19" version="1">MASNSLFSSVTPCQQNFFWDPSTSRRFTPPSSSLQPGKMSEVSPVVVAQQQQQQQQQQQQEAAVPRLRPHDNRTMVEIIADHPGELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGEVPDGTVVTVMAGNDENYSAELRNASAVMKNQVARFNDLRFVGRSGRGKSFTLTITVLTNPPQVATYHRAIKVTVDGPREPRRHRQKLDDSKPSLFPERLSDLGRIPHPSMRVGVPTQSPRPSLNSAPSPFNPQGQSQITDPRQAQSSPPWSYDQSYPSYLSQMTSPSIHSTTPLSSTRGTGLPAITDVPRRLSGASELGPFSDPRQFTSISSLTESRFSNPRMHYPATFTYTPPVTSGMSLGMSATTHYHTYLPPPYPGSSQNQSGPFQTSSTPYLYYGTSSGSYQFPMVPGGDRSPSRMLPPCTTTSNGSTLLNPNLPNQSDGVEADGSHSSSPTVLNSSGRMDESVWRPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SRC2</accession>
    <name>A0A8C2SRC2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribonuclease H</fullName>
            <ecNumber evidence="2">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="2"/>
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        <property type="protein sequence ID" value="ENSCJPP00005002645.1"/>
        <property type="gene ID" value="ENSCJPG00005002966.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000165350"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006259">
        <property type="term" value="P:DNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051320">
        <property type="entry name" value="Viral_Replic_Matur_Polypro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064:SF29">
        <property type="entry name" value="PEPTIDASE A2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064">
        <property type="entry name" value="POL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA/RNA polymerases"/>
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    </dbReference>
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        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNASE_H_1"/>
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    </dbReference>
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        <property type="entry name" value="RT_POL"/>
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    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="RNase H type-1" evidence="4">
        <location>
            <begin position="382"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005002645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="510" mass="58257" checksum="ED11B77B7CCDD709" modified="2022-01-19" version="1">MLELQYELESKEAKWYATIDIANAFFSVPLATECRPQFAFTWRGVQYTWNRLPQGWKHSPTICHGLIQATLEQGGAPEHLQYIDDIVVWGDTATEVFKKGERIIQILLSAGFAIKRDKVKGPAQEIQFLGVKWQDGRRHIPTDVINKITAMSAPTDKKETQSFLGVVGFWRMHIPNYSLIVSPLYQVTRKKNSFAWGPEQQQAFEQIKQEIARAVALGPVRMGQDVKNILYTAAGEKGPTWSLWQRTSDETRGRPLGFWSRAYRGSEEGYTPTEKEILAAYEGVRAASEVIGTETQLLLAPRLPVLNWMFKGQVPSTHHATDATWSKWVALITQRARMGNLSRPGILEVIMDWPEGKKFEAPPAEEVSRAKEAPPYNELPENEKKFALFTDGSCRIVGKHRRWKAAVWSPTRQVAEATEGRGESSQFAEVKAVQLALDIAEREKWPVLYLYTDSWMVANALWGWLQQWEQNNWQRKGKPIWAAELWKNIAARIKKRWPKSSRRCPLPTSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SRN7</accession>
    <name>A0A8C2SRN7_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Somatomedin-B and thrombospondin type-1 domain-containing protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC107323006</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015737171.1">
        <property type="nucleotide sequence ID" value="XM_015881685.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SRN7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005004089.1">
        <property type="protein sequence ID" value="ENSCJPP00005002259.1"/>
        <property type="gene ID" value="ENSCJPG00005002463.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107323006"/>
    <dbReference type="KEGG" id="cjo:107323006"/>
    <dbReference type="GeneTree" id="ENSGT00390000008325"/>
    <dbReference type="OrthoDB" id="98591at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000019">
        <property type="entry name" value="Thrombospondin type 1 domain containing 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SBSPO"/>
    </dbReference>
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        <property type="entry name" value="SBSPON_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036024">
        <property type="entry name" value="Somatomedin_B-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001212">
        <property type="entry name" value="Somatomedin_B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044004">
        <property type="entry name" value="TSP1_spondin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20920">
        <property type="entry name" value="RPE-SPONDIN"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR20920:SF4">
        <property type="entry name" value="SMB DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF25031">
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        <property type="entry name" value="Somatomedin B domain"/>
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    </dbReference>
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        <property type="entry name" value="TSP-1 type 1 repeat"/>
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    </dbReference>
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        <property type="entry name" value="SMB_1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TSP1"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034999955" evidence="4">
        <location>
            <begin position="35"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="SMB" evidence="5">
        <location>
            <begin position="46"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005002259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="274" mass="30167" checksum="90AA2A57096352B9" modified="2022-01-19" version="1">MPRCPGHTTALPPPPPPPLLLFLLLLPAPRPAAAGCAAVGLCCPGRSPSCRSTGWRPDGSYGECYCDQACEQTLDCCHDYNQACPVIPCIVSQWSAWSGCAEPCKMTYRVRRRHIIQEPRNGGEACPALEERAGCVEYWTEQGAECKQSLIPALITTGGFGKARKKRAAADGHERVGYCVEFQLVAITQGCLHSHHSYTHWMQYLREGHTVCVECQHPALDSESLHCYGDGSGSQRNQLLHWQAVGNPRCSGTWKRIRQLDTCSCPSVHSFLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SRU7</accession>
    <name>A0A8C2SRU7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Rho GTPase-activating protein 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Rho-type GTPase-activating protein 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">ARHGAP10</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">GTPase-activating protein that catalyzes the conversion of active GTP-bound Rho GTPases to their inactive GDP-bound form, thus suppressing various Rho GTPase-mediated cellular processes. Also converts Cdc42 to an inactive GDP-bound state. Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death. Associates with MICAL1 on the endosomal membrane to promote Rab8-Rab10-dependent tubule extension. After dissociation with MICAL1, recruits WDR44 which connects the endoplasmic reticulum (ER) with the endosomal tubule, thereby participating in the export of a subset of neosynthesized proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endosome membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015716579.1">
        <property type="nucleotide sequence ID" value="XM_015861093.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SRU7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005003314.1">
        <property type="protein sequence ID" value="ENSCJPP00005001903.1"/>
        <property type="gene ID" value="ENSCJPG00005001985.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107313139"/>
    <dbReference type="KEGG" id="cjo:107313139"/>
    <dbReference type="CTD" id="79658"/>
    <dbReference type="GeneTree" id="ENSGT00940000159559"/>
    <dbReference type="OrthoDB" id="3183924at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="BAR-PH_GRAF_family"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RhoGAP_Graf"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Putative rho GTPase-activating protein 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000006">
        <property type="entry name" value="Rho GTPase activating protein 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000001">
        <property type="entry name" value="Rho GTPase-activating protein 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000055">
        <property type="entry name" value="rho GTPase-activating protein 26 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047234">
        <property type="entry name" value="GRAF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047225">
        <property type="entry name" value="PH_GRAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12552">
        <property type="entry name" value="OLIGOPHRENIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12552:SF5">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16746">
        <property type="entry name" value="BAR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="5" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="PH" evidence="16">
        <location>
            <begin position="265"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="17">
        <location>
            <begin position="388"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="15">
        <location>
            <begin position="721"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="586"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="621"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="598"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="622"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="633"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00054039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00083384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005001903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="779" mass="88998" checksum="BD3D49E9CC0E79B0" modified="2022-01-19" version="1">MGLQPLEFSDCYLDSPWFRERVRAHEAELEKTNKFIKDLLKDGKNLIAATKNLSAAQRKFAHSLRDFKFEFIGDAETDDERYIDASLHEFSNFLKNLEEQREILALSVTETLIKPLERFRKEQLGAVKEEKKKFDKETEKNYSLLEKHLNLSAKKKEVQLQEADNQVEQNRKHFYELSLEYVCKLQEIQERKKFECVEPVLSFFQGLFTFYHQGYELAKDFSHYKMALQINIQNTRNRFEGTRSEVEELMNKIRRNPQEHKRANHNTMEGYLYVQEKRPAPFGSSWVKHYCTYRKETKKFTMIPFEHRSGGKVGDGELFILTYCTKRNVDTIDRRFCFDLESSDRPGVPVTMQAFSEEDRKLWMEALDGKEALFINLNKANAKQEGSAQLDKIGFTVIKKCISAVETRGINDQGLYRVVGVSSKVQRLLSLLMDAKTCNEVDLENSVDWEVKTITSALKQYLRSLPEPLMTYELHGEFIIPAKSGSPESRVNAVHFLVHKLPEKNKEMLDILVKHLANVSKHAKRNLMTVANLGVVFGPTLMRPQEETVAAIMDLKFQNIVVEILIENHEKIFKTLPDVTFPESISMSVSPPNAPPRQSRRQGQRTKRPLAVYNLCLELDDADSHSSPKEDTPTGSMDSLSSQSPTPVLSGSPPGLLDRNHLIMDSGDLADWTTNLSGQSRSSMVSWMNTPCTNPLATNTAPSAFSFPHPSTGSDRAVESVAHRKARAVYPCEAEHSSELSFQTGAIFEDVQFSREPGWLEGTLNGKRGLIPQNYVQFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SS50</accession>
    <name>A0A8C2SS50_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Calponin 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">CNN1</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the calponin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SS50"/>
    <dbReference type="Ensembl" id="ENSCJPT00005004494.1">
        <property type="protein sequence ID" value="ENSCJPP00005002439.1"/>
        <property type="gene ID" value="ENSCJPG00005002691.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159680"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031032">
        <property type="term" value="P:actomyosin structure organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904706">
        <property type="term" value="P:negative regulation of vascular associated smooth muscle cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050606">
        <property type="entry name" value="Calponin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001997">
        <property type="entry name" value="Calponin/LIMCH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000557">
        <property type="entry name" value="Calponin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003096">
        <property type="entry name" value="SM22_calponin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385">
        <property type="entry name" value="CALPONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385:SF12">
        <property type="entry name" value="CALPONIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00402">
        <property type="entry name" value="Calponin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00889">
        <property type="entry name" value="CALPONIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00888">
        <property type="entry name" value="SM22CALPONIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01052">
        <property type="entry name" value="CALPONIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51122">
        <property type="entry name" value="CALPONIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="230"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="251"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005002439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="260" mass="28868" checksum="C2B6DC5CD1A1B86A" modified="2022-01-19" version="1">MSKRELQRGPAYGLSAEVKNKLAQKYDPQTERQLRVWIEGATGRRIGDNFMDGLKDGVILWNFLRAIKHYGVKPHDIFEANDLFENTNHTQVQSTLIALASQAKTKGNNVGLGVKYAEKQQRRFQPEKLREGRNIIGLQVMLRGLQETWRGWGGGTQPRSPLCQPVRHDSLWHQEAGMTAPGTKRQIFEPSLGMERCDTNIIGLQMGSNKGASQQGMTVYGLPRQVYDPKYCDPQVPASGTPSSRIPAPGPQSQGPSSGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SY28</accession>
    <name>A0A8C2SY28_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Histone-lysine N-methyltransferase</fullName>
            <ecNumber evidence="18">2.1.1.355</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="primary">SUV39H1</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60276"/>
            <dbReference type="Rhea" id="RHEA-COMP:15538"/>
            <dbReference type="Rhea" id="RHEA-COMP:15546"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.355"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 18">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.355" evidence="18"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2SY28"/>
    <dbReference type="Ensembl" id="ENSCJPT00005006551.1">
        <property type="protein sequence ID" value="ENSCJPP00005003748.1"/>
        <property type="gene ID" value="ENSCJPG00005003870.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160063"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061773">
        <property type="term" value="C:eNoSc complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033553">
        <property type="term" value="C:rDNA heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140949">
        <property type="term" value="F:histone H3K9 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140947">
        <property type="term" value="F:histone H3K9me2 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042149">
        <property type="term" value="P:cellular response to glucose starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071456">
        <property type="term" value="P:cellular response to hypoxia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007623">
        <property type="term" value="P:circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008340">
        <property type="term" value="P:determination of adult lifespan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097009">
        <property type="term" value="P:energy homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044725">
        <property type="term" value="P:epigenetic programming in the zygotic pronuclei"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045786">
        <property type="term" value="P:negative regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000183">
        <property type="term" value="P:rDNA heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030500">
        <property type="term" value="P:regulation of bone mineralization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000772">
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SYW2</accession>
    <name>A0A8C2SYW2_COTJA</name>
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            <fullName evidence="4">RNA pseudouridine synthase domain containing 1</fullName>
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        <name evidence="4" type="primary">RPUSD1</name>
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        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
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        <property type="component" value="Chromosome 14"/>
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        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pseudouridine synthase"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050188">
        <property type="entry name" value="RluA_PseudoU_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600">
        <property type="entry name" value="MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600:SF87">
        <property type="entry name" value="RNA PSEUDOURIDYLATE SYNTHASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pseudouridine synthase RsuA/RluA-like" evidence="3">
        <location>
            <begin position="57"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005005885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="342" mass="38765" checksum="8706E5E1CBD78B1D" modified="2022-01-19" version="1">MRGDERGRRSERCGGAMRGQTRPARPRPQPRRCPRRALAMEPGTIDNLCILYQSPDFIVVNKHWDIRIDSKMWYETLTLQSQLKHRFPELADPDTYYGFRFCHQLDFSTSGALCVALNKAAAGSAYKCFKDRLVTKAYLALVRGHVDQTRMTIRYAIGKNTVEGMTHMMCIEGTEGCENPKPCQSELIVLEHGSYSGDPVTKVLLQPLTGRTHQLRVHCSAIGHPIVGDFTYSHKKDSGPYRMMLHAYYLRIPTSKELIEVCAPDPFVTAMDGNWVPQRVVHHLDETIQELKDKAVQKGDVGQSQQAVPGHKGEEALSKAKSLELEEQRVQCEQWLAEWALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T0Q2</accession>
    <name>A0A8C2T0Q2_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">General transcription factor IIH subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC107306658</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTF2H2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T0Q2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005010100.1">
        <property type="protein sequence ID" value="ENSCJPP00005006404.1"/>
        <property type="gene ID" value="ENSCJPG00005005958.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00490000043395"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome Z"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01453">
        <property type="entry name" value="vWA_transcription_factor_IIH_type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000282">
        <property type="entry name" value="General transcription factor IIH subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000015">
        <property type="entry name" value="General transcription factor IIH subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007198">
        <property type="entry name" value="Ssl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004595">
        <property type="entry name" value="TFIIH_C1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012170">
        <property type="entry name" value="TFIIH_SSL1/p44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00622">
        <property type="entry name" value="ssl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12695">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12695:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07975">
        <property type="entry name" value="C1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04056">
        <property type="entry name" value="Ssl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015919">
        <property type="entry name" value="TFIIH_SSL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01047">
        <property type="entry name" value="C1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="VWFA" evidence="13">
        <location>
            <begin position="43"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="12">
        <location>
            <begin position="268"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR015919-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="372" mass="42137" checksum="BAE3D55D604ADBE1" modified="2022-01-19" version="1">MDDEPERTKRWEGGYERTWEILKEDESGSLKATIEDILFKMRHLYVVIDGSRTMEDQDLKPNRLTCTLKLLEYFVEEYFDQNPISQVIISAEVFYLFAGNPKKHIVALKKAVDMNCQGEPSLYNSLNLAMQTLKHMPGHTSREVLIVFSSLTTCDPANIYELIKSLKAMKIRVSVIGLSAEVRVCTVLTRETGGTYHVILDESHYKELLMHHVSPPPASSSSECSLIRMGFPQHTIASLSDQDAKPSFSMAQLENNSEPCLTLDGYFCPQCRAKYSELPVECKICGLTLVSAPHLARSYHHLFPLDAFQEIPLEEYQGERYCQGCQAEFKDQSVFVCKMCKNAFCVECDMFVHDSLHCCPGCIHEHPTPASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T0V8</accession>
    <name>A0A8C2T0V8_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transducin beta like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">TBL3</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015732401.1">
        <property type="nucleotide sequence ID" value="XM_015876915.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T0V8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005009466.1">
        <property type="protein sequence ID" value="ENSCJPP00005005944.1"/>
        <property type="gene ID" value="ENSCJPG00005005614.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107320734"/>
    <dbReference type="KEGG" id="cjo:107320734"/>
    <dbReference type="CTD" id="10607"/>
    <dbReference type="GeneTree" id="ENSGT00940000157651"/>
    <dbReference type="OrthoDB" id="5414888at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:002582">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:002453">
        <property type="entry name" value="Transducin beta like 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000230">
        <property type="entry name" value="Transducin beta-like protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013934">
        <property type="entry name" value="Utp13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854:SF15">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08625">
        <property type="entry name" value="Utp13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="105"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="147"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="191"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="381"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="426"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="485"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="527"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="569"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="611"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 13 C-terminal" evidence="7">
        <location>
            <begin position="664"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="699"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005005944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="811" mass="90397" checksum="D730462236418DCF" modified="2022-01-19" version="1">MAAAAGSAVRFKSNYAVSRKIEPFYKGGRVQLSRDGKFMFCPCGTKLNVIDVETGAVLHSLEQDDQEDITSFVLSTDGEILVTGSRALLLKQWNWRENKCVRTWKAVHIAPVATMVFDSTSTLLATGGCDSTIKIWDMIKQYCTHNLKGSSGVVHLVEFHPDISRLQLFSSSMDYKIRIWDLNSSKCVAVLDGHFSAVTSLAFTADGNTLISSGRDKICMVWNLKTRESKRTIPIYESVEAAILLPEQGDFSQLGVKKQGLHFLTAGSKGVLKIWEVATAACVYTQPVPFEPMESEEETSNHSLTHCMLVPEKNEIVTVSVEHNIVFYDAQTLQLRKQLVGYNDEVLDVKFLGPSDSHIVVATNSPQLKVFELSTSHCQILYGHTETILALDVFRKGLMFVSCAKDKSIRVWRMNKEGRVVCVAQGLGHAHGVGTVSCSRLKESFIVTSSQDCTIKVWNIPESLTSKAKAALISSPETLHAQVTERGHDKDINSVAVSPNDKLIATGSQDRLAKLWSCSDCSLLGVFTGHKRGIWCVQFSPVDQILATSSADGTLKLWGLQDFSCLKTFEGHDASVLKIIFVSRGTQLLSGGSDGLLKLWTIKTNECVKTLDGHEDKIWGLHSNKQDDMVVTASSDSSITLWKDVTEIEQEEAEAKREEQIMKEQELSNLLHEKRYLKALGLAISLDRPHTVLTVVKAILKESDGRKRLEENIARLRKDQKEAVLTFLVTWNTNSRNCHEAQAVIETLLKHEAPDDLLQYSGIKSAVESLLPYTERHFQRLSRLLQASMFIDFMWQNMKLSDVSHQEDVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T132</accession>
    <name>A0A8C2T132_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rho guanine nucleotide exchange factor 17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ARHGEF17</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPases.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015708152.2">
        <property type="nucleotide sequence ID" value="XM_015852666.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005010647.1">
        <property type="protein sequence ID" value="ENSCJPP00005006833.1"/>
        <property type="gene ID" value="ENSCJPG00005006203.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107308644"/>
    <dbReference type="KEGG" id="cjo:107308644"/>
    <dbReference type="CTD" id="9828"/>
    <dbReference type="GeneTree" id="ENSGT00940000153798"/>
    <dbReference type="OrthoDB" id="4066896at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.900.10:FF:000025">
        <property type="entry name" value="Rho guanine nucleotide exchange factor 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000206">
        <property type="entry name" value="Rho guanine nucleotide exchange factor 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000434">
        <property type="entry name" value="Rho guanine nucleotide exchange factor 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039919">
        <property type="entry name" value="ARHGEF10/ARHGEF17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12877">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12877:SF15">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19057">
        <property type="entry name" value="PH_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19056">
        <property type="entry name" value="WD40_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="6">
        <location>
            <begin position="931"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="243"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="570"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="719"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="793"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="890"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1434"/>
            <end position="1564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1829"/>
            <end position="1854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="67"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="729"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="798"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="891"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="919"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1436"/>
            <end position="1452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1457"/>
            <end position="1467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1490"/>
            <end position="1509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1547"/>
            <end position="1557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00056029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00074304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1893" mass="204396" checksum="720BA4ECEE567836" modified="2022-01-19" version="1">MAEGGSGRGALQGRMLPASSPPSSSSSSFSFPARKVSPPPNAESPGRAFRSLAPSVRQLSLRFAEPEPAPGPAHAGTPPPPPPPPPPPLPPPLPPRGPALSAEPPPRWPSVPAMRKLFGENGRRSPGCGAGSGSGRASQPPPPPPRSRVPHPALRAARGAPPGPGPHSWHSSTHPPPPPPSSSSSSSSSRSLEEPRRGVEGEGRSSQRLAERDGEAPGKAGSRQPLAPAGPVVARVAKVNLLPFGSPAGSRYASSETLKEEEQPSGCWALHGGRRSPALGPSDGLAWGQPQIRARPKLPSGMAKVSADLGSDALQLVGDRAEHRKSLSNPDIATETLTLLSFLKSDLSELKVKKKGVRIGEAAACDIPTSNLRARSSTQPSGRWAPGERPTLKDLTATLRRAKSFTCSDKSGTRRLFLQSAMKQSSSELLLASASSHDGGRLGDEEEVLPVVIQDQYIQEARQVFEKINRMGSQQDYGLTAEQKDSGGVDGAEEVAPMAGMDVALRGQPVGTQCLKKVELEESVSCRKSMEELLGHDTSVMDEGIVTEPEPGPTRVALGDLHETWQLHDTNVNATEPPPPPAPAAEDALPCKAQAPSEAPSTPSSLRRRRKFPSVGTNGVESGIGEGPGEPYRSLSDPMPHRRCPVAEEAKNFSVDSNLLGSLSSKGGIPQPSAIALAGHAGSAGSDLSLCSDGLRDYSSLIQTIVSQPGAMDKVIDEKGNGKTIKKKSLSDPSRRGELPAGAFEGPSEAISELEGSIPPSSSEPILSEQRAVPVCPQGVGHGYGFDPKLAEVLSPRGARRSSKKRSSRVSHQENQVVPTTMARARPATKHIRHTSEPATFIPITVPEPHAGHHAQHPTLEATHPPVKSFPALQPPSLEDVTKRYMLALNSSDTSPSPGDGSRSSPVTPTAPEPARCPRQPDPRSKPQVDMRKHVIMTLLDTEQSYVESLRTLMQGYMKPLKQPENSLLCDPSLVDEIFDQIPELLEHHEQFLEQIHDCVQNWHEKQKVGDLLVQSFSKDVLVNIYSAYIDNFLNAKDAVRIAKEARPAFMKFLEQSMRENKEKQALSDLMIKPVQRIPRYELLVKDLLKHTPEDHPDHPFLIDAQRNIKQVAERINKGMKSAEEVERNARIVQEIESHIEGMEDLQAPLRRFLRQEMVVEVKAVGGKKDRSLFLFTDLLVCTTLKRKSGSLRRSSMSLYTAASVIDTASKYKLLWKLPLEDVDIIKGASQATNRESIQKSICRLDEDLSTLGQVSKLSETLSFPHQSLDDVIKDLMAAIHRELAEKQSLSFSMAFPPNKVELSAAKADGTESFIFEFPNPDARLGFEQALEDAKKKLASSKNCLDPEFLKAIPIMKTRSGMQFSCASPSHNSPENAHEVWVCNSDGYVGQVCLLSIRKEPIVEACIAVCSARILCIASVPGLKRPYRERMEPIVSPSSEPAPTQSEDSGPQQCLHISISGSSLELSEPVDSTHRELVPFDSDDTDDESSPSPSGTLQSQASHSTISSSFGNEEIPSCKEAAAETTSSEEEQEPGFLPLATAFGQSRRGESPTDGRALRRSSRGSFTRGSLEDLLSLDPEAYQSSMWLGTEDGCIHVYQSSDNIRNRKNSMKMQHAASVMCILYLDNQVFVSLANGELIVYQREPGRFWDPQNSKSLSLGSPGSPITKMVAVAGKLWCGCQNRVIVLNTTTLEQEHTLQVGQDSGRSVSCMVSAAPGVWLSLQGSALVRLYHPTSYEQLAEADITPPVHKMLAGSDAIIRQHKAACLRITALLACQDLLWVGTSAGVVLSLAMPGKRGAEPPPPPLGLPQGHTGHVRFLTAMEVPEGCELRAGGPEQPNDAEQRDPTHPRLPLSKAKMLVISGGDGYEDFRLTNSSESVGRDDSTNHLLLWRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T1X0</accession>
    <name>A0A8C2T1X0_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosylated integral membrane protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">GINM1</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T1X0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005010463.1">
        <property type="protein sequence ID" value="ENSCJPP00005006672.1"/>
        <property type="gene ID" value="ENSCJPG00005006199.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000008373"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042319">
        <property type="entry name" value="GINM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28549">
        <property type="entry name" value="GLYCOPROTEIN INTEGRAL MEMBRANE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28549:SF1">
        <property type="entry name" value="GLYCOPROTEIN INTEGRAL MEMBRANE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="329" mass="37790" checksum="4EA7C2DC7650FF5D" modified="2022-01-19" version="1">GEGNKLASKWPFSCQLNELLTDLAEMGWKEDVPERELQSVSQTELQHRGRTAHSFRLSVFQVVFNITYVNGQMYLNDFPMRSGVAHITCQTVICEYSLFIFLEQQRLGTVSVRIMVHEWPLASSSDLQLIVIQEEVTEIDGRQVQQEEVTEIDILVKDLRVLRHSNYTVPLKESMLYSIPRDNDVLFTLPNLSGKDIQDPLQTTSQYLIWQVETTVDEETLPGKLPETPLRIEPQSSYKVMCQWVEDLRKWLCRFWFKSLPIFFNLMEVIVVGVIGAALILKVLKVIFPSCEPKGILLLDQVSFLPVVTISLPSDVPDRKNNLDERTCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T2D5</accession>
    <name>A0A8C2T2D5_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ran-binding protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">RANBP3</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with CHC1 in a Ran-stimulated manner. Interacts with XPO1. Interacts (via its C-terminal R domain) with SMAD2 (dephosphorylated form via its MH1 and MH2 domains); the interaction results in the nuclear export of SMAD2 and termination of the TGF-beta signaling. Interacts (via its C-terminal R domain) with SMAD3 (dephosphorylated form via its MH1 domain); the interaction results in the nuclear export of SMAD3 and termination of the TGF-beta signaling.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T2D5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005010290.1">
        <property type="protein sequence ID" value="ENSCJPP00005006532.1"/>
        <property type="gene ID" value="ENSCJPG00005006096.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158588"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070412">
        <property type="term" value="F:R-SMAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13180">
        <property type="entry name" value="RanBD_RanBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000106">
        <property type="entry name" value="ran-binding protein 3 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045255">
        <property type="entry name" value="RanBP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138">
        <property type="entry name" value="RAN BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138:SF91">
        <property type="entry name" value="RAN-BINDING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00638">
        <property type="entry name" value="Ran_BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00160">
        <property type="entry name" value="RanBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50196">
        <property type="entry name" value="RANBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RanBD1" evidence="13">
        <location>
            <begin position="374"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="49"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="309"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="502"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="192"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="206"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="266"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="315"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00058720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00065474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00072605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="550" mass="59567" checksum="1D9C45852AD2CC4E" modified="2022-01-19" version="1">MRSWCRTQEGREVKDVLYVTTNTACVFHYKEQISCASQREKPAIAPPVFVFQKDKAQKRSADGSSPEDGDESDREDGNYCPPVKRERTSSLTQFPPSQSVTKNNVFMPSSFCEPSAGNSDSEPEEKSSGFRLKPPILIHGQAPSAGLPSQKPKEQQRSVLRPAVLQAPQPKAFSQMVLSSGTNGVNIPPDSAATSESLSNATLKSSDSEDKAGECQKKESNSTSDDDSGEKAEQNAQQAFVFGQNLRDRVKLGDESDETADVQNAGLPTSDTPSATNYFLQYISSSIENSTNSADASSNKFVFGQNMSERVLSPPKSNEGSTESNKENAATESGSESSSQEATPEKANNISESLAESAAAYTKATARKCLLAKVEVITGEEAESNVLQIQCKLFVFDKNSQSWVERGRGLLRLNDMASTDDGTLQSRLVMRTQGSLRLILNTKLWAQMQIDKASEKSIRITAMDTEDQGVKVFLISASSKDTGQLYAALHHRILALRSRVEQEQEVKNVAPEPEVTQSNEEDSDDDVLAPSGSVGSGPSDERDGQNAGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T324</accession>
    <name>A0A8C2T324_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cocaine- and amphetamine-regulated transcript protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">CARTPT</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CART family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015705432.1">
        <property type="nucleotide sequence ID" value="XM_015849946.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T324"/>
    <dbReference type="Ensembl" id="ENSCJPT00005010115.1">
        <property type="protein sequence ID" value="ENSCJPP00005006417.1"/>
        <property type="gene ID" value="ENSCJPG00005006000.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107306639"/>
    <dbReference type="KEGG" id="cjo:107306639"/>
    <dbReference type="CTD" id="9607"/>
    <dbReference type="GeneTree" id="ENSGT00390000018319"/>
    <dbReference type="OrthoDB" id="9118670at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome Z"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030141">
        <property type="term" value="C:secretory granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005184">
        <property type="term" value="F:neuropeptide hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008343">
        <property type="term" value="P:adult feeding behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032099">
        <property type="term" value="P:negative regulation of appetite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045779">
        <property type="term" value="P:negative regulation of bone resorption"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007218">
        <property type="term" value="P:neuropeptide signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045777">
        <property type="term" value="P:positive regulation of blood pressure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032812">
        <property type="term" value="P:positive regulation of epinephrine secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051971">
        <property type="term" value="P:positive regulation of transmission of nerve impulse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd22741">
        <property type="entry name" value="CART_CTD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.40.30:FF:000001">
        <property type="entry name" value="Cocaine-and amphetamine-regulated transcript protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.40.30">
        <property type="entry name" value="CART, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009106">
        <property type="entry name" value="CART"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036722">
        <property type="entry name" value="CART_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16655">
        <property type="entry name" value="COCAINE AND AMPHETAMINE REGULATED TRANSCRIPT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16655:SF0">
        <property type="entry name" value="COCAINE- AND AMPHETAMINE-REGULATED TRANSCRIPT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06373">
        <property type="entry name" value="CART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64546">
        <property type="entry name" value="Satiety factor CART (cocaine and amphetamine regulated transcript)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0527">Neuropeptide</keyword>
    <keyword evidence="6" id="KW-0529">Neurotransmitter</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034241011" description="Cocaine- and amphetamine-regulated transcript protein" evidence="10">
        <location>
            <begin position="23"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="110" mass="11855" checksum="57ED91E0034EEB98" modified="2022-01-19" version="1">MESCRALALCAVAAALLLSARGQGPAPPRRDRDLGPNGAGTSREKELIEALQEVLEKLKSKRVPHYEKKFGQVPMCDAGEQCAVRKGARIGKLCDCPRGTSCNSFLLKCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T330</accession>
    <name>A0A8C2T330_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Nuclear valosin-containing protein-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">NVL</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Participates in the assembly of the telomerase holoenzyme and effecting of telomerase activity via its interaction with TERT. Involved in both early and late stages of the pre-rRNA processing pathways. Spatiotemporally regulates 60S ribosomal subunit biogenesis in the nucleolus. Catalyzes the release of specific assembly factors, such as WDR74, from pre-60S ribosomal particles through the ATPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Interacts with NCL/nucleolin. Isoform 1 and isoform 2 interact with TERT and isoform 1 exhibits a higher binding affinity for TERT compared to isoform 2. Isoform 1 interacts with MTREX in an ATP-dependent manner; the interaction is required to associate NVL with nuclear RNA exosome. Isoform 1 interacts with RPL5 in an ATP-dependent manner. Interacts with WDR74 (through WDR repeats); the interaction is independent of RNA or pre-60S ribosome particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T330"/>
    <dbReference type="Ensembl" id="ENSCJPT00005011950.1">
        <property type="protein sequence ID" value="ENSCJPP00005007791.1"/>
        <property type="gene ID" value="ENSCJPG00005006952.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00570000079239"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005697">
        <property type="term" value="C:telomerase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990275">
        <property type="term" value="F:preribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032206">
        <property type="term" value="P:positive regulation of telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904749">
        <property type="term" value="P:regulation of protein localization to nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905323">
        <property type="term" value="P:telomerase holoenzyme complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd19518">
        <property type="entry name" value="RecA-like_NVL_r1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19530">
        <property type="entry name" value="RecA-like_NVL_r2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2010:FF:000001">
        <property type="entry name" value="Nuclear valosin-containing protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000063">
        <property type="entry name" value="Nuclear valosin-containing protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000172">
        <property type="entry name" value="Nuclear valosin-containing protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000149">
        <property type="entry name" value="Nuclear valosin-containing protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000600">
        <property type="entry name" value="Nuclear valosin-containing protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2010">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038100">
        <property type="entry name" value="NLV2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031996">
        <property type="entry name" value="NVL2_nucleolin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF171">
        <property type="entry name" value="NUCLEAR VALOSIN-CONTAINING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16725">
        <property type="entry name" value="Nucleolin_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="272"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="587"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="86"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="189"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="195"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00063085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00067714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005007791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="822" mass="91082" checksum="1E0E16881E525474" modified="2022-01-19" version="1">MRSRPGSFVDLRLKQRVKQYLASSKCGHYVDIGILASDLQKTYSTEYGRRKRNAFRIQVAKVFGIISNEKKKEDLTALEAEHLAKRARHEHKRNETTGSSTEDSEDDDYPEDLSTNHMNSSLMTLYKKGNPDSVPATPKNEPMETSTPGQTAPQTSTHSPASQVETRITKGGWFIDKNPSGKDFFIDLSEDGEGDEKKPISEKSTEFSVLESEKKKTKGKRAKRKKEEFPDVDEEIESILLKRKGEKLFLEICKMLIHVRHPEVYLHLGVVPPRGFLLHGPPGCGKTLLAQAIAGELELPMLKVAATEMVSGVSGESEQKLRELFDQAVLNAPCVLFIDEIDAITPKREVASKDMERRIVAQLLTCLDDLNNAAATAQVLVIGATNRPDSLDPALRRAGRFDREICLGIPDEAAREKILQTLCRKLKLPESFDFLHLAHLTPGYVGADLMALCREAAMCTVNRVLIKTEKQQGKYMQAGGNATEESMGIETEIPVKENEELQRLLDLLKEQDPLPEEQLQKLCIEMNDFIVALSSVQPSAKREGFVTIPDVTWADIGALEDVREELTMAILAPVRNPEQFKALGLTTPAGVLLAGPPGCGKTLLAKAVANESGLNFISVKGPELLNMYVGESERAVRQVFQRARNSAPCVIFFDEVDALCPRRSDRESGASVRVVNQLLTEMDGLENRQQVFIMAATNRPDIIDPAILRPGRLDKTLYVGLPPPEDRFAILKTITKDGTRPPLDADVNLEEIAYSQQCDCYTGADLSALVREASICALRQEMALPSANSKKGEIKISHKHFEEAFRKVKSSVSKKVRTASGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T3F5</accession>
    <name>A0A8C2T3F5_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Hepatic and glial cell adhesion molecule</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">HEPACAM</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Endomembrane system</location>
            <topology evidence="11">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T3F5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005009245.1">
        <property type="protein sequence ID" value="ENSCJPP00005005749.1"/>
        <property type="gene ID" value="ENSCJPG00005005431.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01130000278319"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097450">
        <property type="term" value="C:astrocyte end-foot"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0150105">
        <property type="term" value="P:protein localization to cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000922">
        <property type="entry name" value="hepatocyte cell adhesion molecule isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052280">
        <property type="entry name" value="HEPACAM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44888">
        <property type="entry name" value="HEPACAM FAMILY MEMBER 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44888:SF2">
        <property type="entry name" value="HEPATIC AND GLIAL CELL ADHESION MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="14">
        <location>
            <begin position="139"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="263"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="335"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="283"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="345"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="366"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="377"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005005749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="408" mass="44376" checksum="5CFBD482E0EB7BFF" modified="2022-01-19" version="1">SHYPHKSLKKQSKALKQAPSLLAGVNITSPSALVRGTAGKAALLSVRYASASPDKPVVKWQLKRDKPVTVVQSIGTEIIGNLRPDYRDRIRVLENGSLLISPLQLADEGSYEVEVSITDDTFTGEKTINLTVDIPISKPQVLVASSTVLELSEFFTLNCSHENGTKPTYTWLKDGRPLNNDSRLLLSPDQKILTITRVLMADDDVYSCLVENPISQGRSVPVKLTVYRRSSLYIILSTGGIFLLVTLVTVCACWKPSKNLCSLSRPKQQAEPPPPDYTEQDEEHPKHEAETIPRGADHDRKTPLALYILKEQVSGGRAGMPRSAMQSIALTLVPPQDTAAPQEDSSPPAGRSPGRGARRYHRSPAPARPPRSPPGSPARSRSAARLLRAAGVPAIREQEEGSALEISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T3I5</accession>
    <name>A0A8C2T3I5_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Natriuretic peptides A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC107323379</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T3I5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005010865.1">
        <property type="protein sequence ID" value="ENSCJPP00005006987.1"/>
        <property type="gene ID" value="ENSCJPG00005006455.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00960000187988"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051427">
        <property type="term" value="F:hormone receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097746">
        <property type="term" value="P:blood vessel diameter maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006182">
        <property type="term" value="P:cGMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019934">
        <property type="term" value="P:cGMP-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003085">
        <property type="term" value="P:negative regulation of systemic arterial blood pressure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007218">
        <property type="term" value="P:neuropeptide signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000663">
        <property type="entry name" value="Natr_peptide"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050787">
        <property type="entry name" value="Natriuretic_peptide"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002408">
        <property type="entry name" value="Natriuretic_peptide_brain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14066">
        <property type="entry name" value="ATRIAL NATRIURETIC FACTOR PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14066:SF10">
        <property type="entry name" value="NATRIURETIC PEPTIDES B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00212">
        <property type="entry name" value="ANP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00712">
        <property type="entry name" value="BNATPEPTIDE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00183">
        <property type="entry name" value="NAT_PEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0838">Vasoactive</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034264479" evidence="7">
        <location>
            <begin position="23"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="45"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="127" mass="14167" checksum="627FF0ED9588BD3B" modified="2022-01-19" version="1">MQLLALCCRTSLLLLFMPWAGGENDAELQSLQELLEALEQLQEEEGAPALEDELGAGAEIDGSEGALLPAPSPPQPEEGQSQWRSLLSSYRRRQFSGCFGTRMERIGAQTGLGCNHYKARFWRRRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T3R9</accession>
    <name>A0A8C2T3R9_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Gamma-secretase subunit APH-1</fullName>
            <shortName evidence="7">APH-1</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC107305821</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Potential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the gamma-secretase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the APH-1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T3R9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005010895.1">
        <property type="protein sequence ID" value="ENSCJPP00005007012.1"/>
        <property type="gene ID" value="ENSCJPG00005006473.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000002049"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome Z"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070765">
        <property type="term" value="C:gamma-secretase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009294">
        <property type="entry name" value="Aph-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12889">
        <property type="entry name" value="GAMMA-SECRETASE SUBUNIT APH-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06105">
        <property type="entry name" value="Aph-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU369072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005007012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="270" mass="30039" checksum="D16936DC402463DF" modified="2022-01-19" version="1">MTLAVFFGCTFIAFGPAFSLFLFTIARDPLRIIILIAGAFFWLVSLLLSSLIWFIAVKVSDPRDEPLQKGLLIFGVMFSVLLQEAFRFLYYKLLRKAIEGLVALSEDGCSPISIQQMAYVAGVGFGLMSGAFSMINLLADALGPGTVGIHGDSQLYFLTSAFMTMVLIFLHTFWGILFFHGCENRHWWEILAVVVMHLAVSGSTFFNPLYVGSLVPSYVLMAIAAVWAYMLSGGSLQNLRRFLLCKSPTWWFLLLLCPEVGQSVLEAEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T3U8</accession>
    <name>A0A8C2T3U8_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Protein eyes shut homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
            <location evidence="3">Extracellular space</location>
            <location evidence="3">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSCJPT00005012430.1">
        <property type="protein sequence ID" value="ENSCJPP00005008151.1"/>
        <property type="gene ID" value="ENSCJPG00005007343.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000165329"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048646">
        <property type="term" value="P:anatomical structure formation involved in morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009952">
        <property type="term" value="P:anterior/posterior pattern specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048589">
        <property type="term" value="P:developmental growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045197">
        <property type="term" value="P:establishment or maintenance of epithelial cell apical/basal polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030097">
        <property type="term" value="P:hemopoiesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007157">
        <property type="term" value="P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051241">
        <property type="term" value="P:negative regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050877">
        <property type="term" value="P:nervous system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051240">
        <property type="term" value="P:positive regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035282">
        <property type="term" value="P:segmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048863">
        <property type="term" value="P:stem cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="30"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000142">
        <property type="entry name" value="Crumbs cell polarity complex component 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000012">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000318">
        <property type="entry name" value="Eyes shut homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000508">
        <property type="entry name" value="Eyes shut homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000004">
        <property type="entry name" value="Neurogenic locus notch 1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000279">
        <property type="entry name" value="Neurogenic locus notch 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000100">
        <property type="entry name" value="neurogenic locus notch homolog protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000327">
        <property type="entry name" value="neurogenic locus notch homolog protein 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000143">
        <property type="entry name" value="Protein crumbs 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000122">
        <property type="entry name" value="Protein crumbs homolog 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000722">
        <property type="entry name" value="Protein eyes shut homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000183">
        <property type="entry name" value="Protein eyes shut homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000190">
        <property type="entry name" value="Protein eyes shut homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000210">
        <property type="entry name" value="Protein eyes shut homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000045">
        <property type="entry name" value="Slit guidance ligand 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000472">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000006">
        <property type="entry name" value="Versican core protein-like isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="38"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051022">
        <property type="entry name" value="Notch_Cell-Fate_Det"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049">
        <property type="entry name" value="CRUMBS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049:SF26">
        <property type="entry name" value="EYES SHUT HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25024">
        <property type="entry name" value="EGF_TEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="38"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="36"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T4C5</accession>
    <name>A0A8C2T4C5_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 8 open reading frame 76</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">C8orf76</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T4C5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005009667.1">
        <property type="protein sequence ID" value="ENSCJPP00005006097.1"/>
        <property type="gene ID" value="ENSCJPG00005005730.1"/>
    </dbReference>
    <dbReference type="KEGG" id="cjo:107310491"/>
    <dbReference type="GeneTree" id="ENSGT00390000011435"/>
    <dbReference type="OrthoDB" id="6334002at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041404">
        <property type="entry name" value="DUF5588"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31919">
        <property type="entry name" value="ZINC FINGERS AND HOMEOBOXES PROTEIN 1, ISOFORM 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31919:SF1">
        <property type="entry name" value="ZINC FINGERS AND HOMEOBOXES PROTEIN 1, ISOFORM 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17826">
        <property type="entry name" value="DUF5588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="403" mass="44981" checksum="353ED64A06D9FE6A" modified="2022-01-19" version="1">MEMELPLGWEFEEAVFSQSRERGAGGGAGPPYSAKRCEPRWFCAETSSEEDAEVLTAHKFRADLAYRERQFEKALCEYSNCLQRLPPGNIAMRRDVQEGQARCLSQLGRHKEALDIAEGMRNGATNTDHLTTVLNLQFAIYRDLENIEKKMVCLQQLICLHPFNPWYWKSLAEAYMDLLQSLSPLHIPEANLNQSEEVSDGSFKMSAGGEINLHPHRSDCQREGPQSGPEAETRSESAETCSSSQAVTETLRTSDSAGRKAEGKQAACESWEPDMAKDVGVKACASFVRARLLLQLTQLQQSSFALENNIKCQKEIDDKVAQFGLNENSLLQVTKVMGADLVPEKLKEEFQGEVKCIGSSALSSLVTTTASEFEIKWFDILRDDLRHLDGQFSPDIHIPPLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T5F2</accession>
    <name>A0A8C2T5F2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Complex I-B14.7</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">NADH-ubiquinone oxidoreductase subunit B14.7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">NDUFA11</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I NDUFA11 subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015741946.2">
        <property type="nucleotide sequence ID" value="XM_015886460.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T5F2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005010302.1">
        <property type="protein sequence ID" value="ENSCJPP00005006541.1"/>
        <property type="gene ID" value="ENSCJPG00005006111.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107325519"/>
    <dbReference type="KEGG" id="cjo:107325519"/>
    <dbReference type="CTD" id="126328"/>
    <dbReference type="GeneTree" id="ENSGT00390000012434"/>
    <dbReference type="OrthoDB" id="1913277at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039205">
        <property type="entry name" value="NDUFA11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21382:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21382">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="200" mass="20505" checksum="B312084D9BB71D67" modified="2022-01-19" version="1">MCGGTDVCRNRCVSEPMCVGTDVWRNGTARGQGGGGSTGPAGADLARGALCSRESSAVPVPLYMMAGYWDGPEGERCPERTWLSTRVGAAAGLLGSAYRIILLRPGSALAALQMAASDTVTMATLGAVFGVTTCISAQLRDEHDSPLDYFIGGCTTGAVLGARAHSYMTGTVACLGLGTAAALMKIGNKEGWRLTGPPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T650</accession>
    <name>A0A8C2T650_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide repeat domain 33</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">TTC33</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T650"/>
    <dbReference type="Ensembl" id="ENSCJPT00005013443.1">
        <property type="protein sequence ID" value="ENSCJPP00005008938.1"/>
        <property type="gene ID" value="ENSCJPG00005007920.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000017462"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome Z"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052658">
        <property type="entry name" value="TPR-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15544">
        <property type="entry name" value="OSMOSIS RESPONSIVE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15544:SF0">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="97"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005008938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="299" mass="33468" checksum="00B57327275F2C4E" modified="2022-01-19" version="1">MKGVLLHVTAQDEQAVFVFPHAVNLALLIAEICFPLVLPMASFGWKRKIGEKVSRATSQQFEAEAAEEKGPGGDEDEDWVNAAKRRKEVIEDCVKKSKQLKDEGASLAENRRYREAIQKWDEALQLTPEDATLYEMKSQVLMSLHEMFPAVHAAEMAVQRNPRSWDAWQTLGRAQLGLGEIVLAIRSFQISLHIFPMNPEVWKEDLSWARKLHEQQKATKTEAEQSQAKGKEIAQASIPDYDFESDEIVAVCAAIAEKEKALSEAKTVVIVSASGTVETVTEKENCTSTPDESIFIRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T684</accession>
    <name>A0A8C2T684_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Tumor protein p53 binding protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">TP53BP2</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ASPP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T684"/>
    <dbReference type="Ensembl" id="ENSCJPT00005012031.1">
        <property type="protein sequence ID" value="ENSCJPP00005007858.1"/>
        <property type="gene ID" value="ENSCJPG00005007112.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153463"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030054">
        <property type="term" value="C:cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051059">
        <property type="term" value="F:NF-kappaB binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002039">
        <property type="term" value="F:p53 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072332">
        <property type="term" value="P:intrinsic apoptotic signaling pathway by p53 class mediator"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900119">
        <property type="term" value="P:positive regulation of execution phase of apoptosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd17225">
        <property type="entry name" value="RA_ASPP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11953">
        <property type="entry name" value="SH3_ASPP2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Apoptosis-stimulating of p53 protein 2 isoform 1"/>
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    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000030">
        <property type="entry name" value="Apoptosis-stimulating of p53 protein 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047163">
        <property type="entry name" value="ASPP1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048942">
        <property type="entry name" value="ASPP2-like_RA"/>
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    <dbReference type="InterPro" id="IPR047166">
        <property type="entry name" value="ASPP2_RA"/>
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        <property type="entry name" value="RA_dom"/>
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    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24131">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24131:SF8">
        <property type="entry name" value="APOPTOSIS-STIMULATING OF P53 PROTEIN 2"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    <dbReference type="PRINTS" id="PR01887">
        <property type="entry name" value="SPECTRNALPHA"/>
    </dbReference>
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        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="Ras-associating" evidence="15">
        <location>
            <begin position="2"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="954"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="987"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="14">
        <location>
            <begin position="1053"/>
            <end position="1115"/>
        </location>
    </feature>
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            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
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            <begin position="315"/>
            <end position="337"/>
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    <feature type="region of interest" description="Disordered" evidence="13">
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            <end position="430"/>
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            <begin position="528"/>
            <end position="594"/>
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    </feature>
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            <begin position="825"/>
            <end position="850"/>
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    </feature>
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        <location>
            <begin position="317"/>
            <end position="328"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
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            <begin position="393"/>
            <end position="410"/>
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        <location>
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    </evidence>
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    <sequence length="1124" mass="125276" checksum="154EE78B5A7FDBDC" modified="2022-01-19" version="1">LFQMFLTVYLSNNEQHFTEVPVTPETTCRDVVELCKEPGESECHLAEVWCGSERPIADNERMLDILQRFGMQRGEVRFFLRHERSPCRESGRSQDPVLKRNGVKMPGDRRMENGVSAPRMDMTLAELQEMASRQQQQIEAQQQMLANKEQRLKFLKQQDQRQQQQAAEQEKLKRLKEIAENQEAKLKKVRALKGHVEQKRLSNGKLVEEIEQMNSLFQQKQRELVLAVSKVEELTRQLEMLKNGRIDGYHDNQSAVAELDRLYKELQLRNKLNQEQNAKLQQQRECLNKRNSEVAVMDKRVNELRERLWKKKAALQQKENVPVSSDGNLPQAVGSAPSRVAAVGPYIQSSTMPRIASRPELLVKPAFSDGTQALQASDGPLKTQTLPNMRAGSSSVVPSSKPSPSAEWSSLNTDNHLSQGSALTSGKGTMAGEDAYLRDKEKKVRPFSMFDSVDQSAGLGMLRKNQSSEDLLREAQVSNKNVTKVPPPVPTKPKQINLPYFGQANHQQLSDPKLDGNLQKLPLAVASMGSKQKPVAQQPSHSQQIQRISVPPVGPSSSQDQILPSSKQESPPAAAVRPFTPQPSKETSLPPFRKPQTVAASSIYSMYTQQQTPGKNFQQAVQSALTRAQTRAPHFPSVYGKPVMAGAGVQNQLPQTENIYSNLQGKPGSPEPEMETTASAHESHETERIPRPLSPTKLLPFLSNPYRNQSDADLEALRKKLSNAPRPLKKRSSITEPEGPNGPNIQKLLYQRTTLAAMETISAPSHPSKQTASAVSPESPVEIPNPYASAESEKETVSSMPEPTIAEEAENIPADQSEAVLPSTVLDPVPEGVSDSDESMQPKMEEPSHEAPLPLEVYMEEYPPYPPPPYPSGEPESLGEDSFNMRPPEVTGQFSLPPGKRTNLRKAGSDRIAHGMRVKFNPLALLLDSSLEGEFDLVQRIIYEVEDPSMPNDEGITALHNAVCAGHTEIVKFLLEFGVNVNAADSDGWTPLHCAASCNNVQVCKFLVESGAAVFATTYSDMQTAADKCEEMEDGYTQCSQFLYGVQEKMGIMNKGVIYGLWDYEAQNDDELSMKEGDCMTILRREDEDEIEWWWARLNDKEGYVPRNLLGLYPRIKPRQRSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T6W1</accession>
    <name>A0A8C2T6W1_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Leucine rich repeat containing 8 VRAC subunit B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LRRC8B</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>chloride(in) = chloride(out)</text>
            <dbReference type="Rhea" id="RHEA:29823"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>iodide(out) = iodide(in)</text>
            <dbReference type="Rhea" id="RHEA:66324"/>
            <dbReference type="ChEBI" id="CHEBI:16382"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>taurine(out) = taurine(in)</text>
            <dbReference type="Rhea" id="RHEA:66328"/>
            <dbReference type="ChEBI" id="CHEBI:507393"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LRRC8 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015725553.1">
        <property type="nucleotide sequence ID" value="XM_015870067.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015725554.1">
        <property type="nucleotide sequence ID" value="XM_015870068.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T6W1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005014024.1">
        <property type="protein sequence ID" value="ENSCJPP00005009379.1"/>
        <property type="gene ID" value="ENSCJPG00005008244.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107317419"/>
    <dbReference type="KEGG" id="cjo:107317419"/>
    <dbReference type="CTD" id="23507"/>
    <dbReference type="GeneTree" id="ENSGT00940000160703"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005225">
        <property type="term" value="F:volume-sensitive anion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000089">
        <property type="entry name" value="volume-regulated anion channel subunit LRRC8B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000225">
        <property type="entry name" value="volume-regulated anion channel subunit LRRC8B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052595">
        <property type="entry name" value="LRRC69/RLP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021040">
        <property type="entry name" value="LRRC8_Pannexin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48057">
        <property type="entry name" value="LEUCINE-RICH REPEAT SERINE/THREONINE-PROTEIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48057:SF7">
        <property type="entry name" value="LEUCINE-RICH REPEAT SERINE_THREONINE-PROTEIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12534">
        <property type="entry name" value="Pannexin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="10 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="LRRC8 pannexin-like TM region" evidence="18">
        <location>
            <begin position="1"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="189"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00024167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF12534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005009379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="801" mass="92996" checksum="04AE8FFB48235FA8" modified="2022-01-19" version="1">MITLTELKFLADAQSSYHILKPWWDVFWYYLTMIMLLVAVLAGALQLTQTRVLCCLPCKLEFDNHCAVPWDLIKTNLNMSASSTAQIIIPLKIQNDLHRQQYSYIDAVCYERQLHWFAKFFPYLVLLHTFIFAACSNFWLYYPSTSSRLEHFVAILQKCFDSPWTTRALSETVAEQSVRKSPIAKSKAVISSPGSSVDVGASRQSLPYTQPGLETTGRENSSVLDKKEGEQAKAIFEKVKKFRVHVEEKDVIYRVYMKQIIVKVIVFVIIIIYVPYYLSFIKLEIDCIVNVQAFTGYKRYQCVYSLAEIFKVLASFYVVLVIFYGLTCTYSLWWMLRSSLKQYSFEKLREKSNYSDIPDVKNDFAFILHLADQYDPLYSQRFSIFLSDLSENKLKQINLNNEWSVEKLKNKLVRNSQDKVELHLFILSGLPDSVFELTEIEVLTLELIPEAKLSSAVSQLVNLKDLNVYHSSITMDYPAVSFLEENLKTLRLKSSEMGRIPFWVFHLKNLKELCLTGYFMLDHHNSIYNESFQGLKNLRSIHLKNNLSRIPQVITDLLPSLQHLSINNEGNKLIVLNNLKKLVNLRTLELICCDLERIPHSIFTLNNLHEIDLRENNLRTVEEIISFQHLKNLSCLKLWHNSISYVPLQIGALSNLEQLYLNYNNIKDVPLQLFLCKKLQYLDLSYNKLTSIPEEIGYLTNLQYLALTKNHIEMLPDRLFQCKKLQFLLLGNNSLMNLSPLVGQLLNLVHLELIGNYLESLPAELEECQFLKRNSLIVEERLLKTLPPRVRDRLQTSSDKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T7D8</accession>
    <name>A0A8C2T7D8_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Single-pass membrane protein with coiled-coil domains 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">SMCO3</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015715150.1">
        <property type="nucleotide sequence ID" value="XM_015859664.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015715158.1">
        <property type="nucleotide sequence ID" value="XM_015859672.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T7D8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005014280.1">
        <property type="protein sequence ID" value="ENSCJPP00005009568.1"/>
        <property type="gene ID" value="ENSCJPG00005008397.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107312347"/>
    <dbReference type="KEGG" id="cjo:107312347"/>
    <dbReference type="CTD" id="440087"/>
    <dbReference type="GeneTree" id="ENSGT00390000013440"/>
    <dbReference type="OrthoDB" id="6112619at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027895">
        <property type="entry name" value="DUF4533"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040004">
        <property type="entry name" value="SMCO3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35972">
        <property type="entry name" value="SINGLE-PASS MEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35972:SF1">
        <property type="entry name" value="SINGLE-PASS MEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15047">
        <property type="entry name" value="DUF4533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="185"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005009568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="225" mass="25119" checksum="0E91E2870B3CC498" modified="2022-01-19" version="1">MALSDLIYPENPRRRQELIHLHQELFGCMSMNFHATNELAEVLNAHLGCTITHIKMRESSTVKENCDIIIRAMREIQCQVQKIDGDMKEKLEPVLYQKLYDIKEPELEKIAIAHKVFSILLGEATSAAGMVAVKLLSSNLITITVCKLVSLLAQIGASVLGGISITVLGLGMEMILHAILGAVERNQLLAAVRSYEEHLAEFKEASEKYQCAIREVTSLVRHQVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T9G9</accession>
    <name>A0A8C2T9G9_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T9G9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005014100.1">
        <property type="protein sequence ID" value="ENSCJPP00005009438.1"/>
        <property type="gene ID" value="ENSCJPG00005008278.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00910000147048"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005009438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="130" mass="14388" checksum="B206E409D85615DB" modified="2022-01-19" version="1">MVAVRRKFFWCLFRVEPGHAVFKLQTVLRKGSPEHGRFDVTLQIPKEPDQIGVSFLSLLGDGFTCCSLLAFGCSLAAFVSRTPSLCCCEAPPRFSASSSSCCSDLARCNSRSCTRSSMMASRSSWIAWFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T9T8</accession>
    <name>A0A8C2T9T8_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb/SANT-like DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T9T8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005015424.1">
        <property type="protein sequence ID" value="ENSCJPP00005010413.1"/>
        <property type="gene ID" value="ENSCJPG00005009066.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00960000187715"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028002">
        <property type="entry name" value="Myb_DNA-bind_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23098">
        <property type="entry name" value="AGAP001331-PA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23098:SF22">
        <property type="entry name" value="MYB-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13873">
        <property type="entry name" value="Myb_DNA-bind_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like DNA-binding" evidence="2">
        <location>
            <begin position="15"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005010413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="405" mass="43863" checksum="06C8E60C917E7CC1" modified="2022-01-19" version="1">MAAAGGAARRGLLKRKPNFTLQEIEILMSEVLRYEPLLFGAAASTVNAYEKQKIWWRITNKINAAGRNQRDIGEVKNRWRGLRRRANDKITRHRQERQGPAPRPNANRHHGAAGTGTAELGPGPAPRAAPAPEGEAVALLALSEEAQWVIAAIPLVTRAAAERQRLAVEAGVPRAVLVHVPQTVLAPRHWGPPLSPRCHHPGATSSSPRLQPRVGTLCVSLRPVPRSMPSPQPCQATVPPSTPPPCPHIPLHAVPMSSYPFDPTLISPYLTHPTSHTLSHSVPTFLYPVLSHSHAPTLAPRPHTPLHPSRLHPTPHPHTPIPIRPPNPQLYPIPTSPHPFNPSPRPHAALHPTPTFPPIHLLIPAPSTTSPRPIPVPSPSHPLVPRPGSPPHPALFLSPPPSLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TAV6</accession>
    <name>A0A8C2TAV6_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Arginine--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Arginyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">RARS1</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Arg) + L-arginine + ATP = L-arginyl-tRNA(Arg) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="3"/>
    <dbReference type="RefSeq" id="XP_015731412.1">
        <property type="nucleotide sequence ID" value="XM_015875926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TAV6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005014835.1">
        <property type="protein sequence ID" value="ENSCJPP00005009978.1"/>
        <property type="gene ID" value="ENSCJPG00005008726.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107320245"/>
    <dbReference type="KEGG" id="cjo:107320245"/>
    <dbReference type="CTD" id="5917"/>
    <dbReference type="GeneTree" id="ENSGT00530000063407"/>
    <dbReference type="OrthoDB" id="68056at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00671">
        <property type="entry name" value="ArgRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000016">
        <property type="entry name" value="Arginine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.70:FF:000002">
        <property type="entry name" value="arginine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000084">
        <property type="entry name" value="arginine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="entry name" value="Arginyl tRNA synthetase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00123">
        <property type="entry name" value="Arg_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005148">
        <property type="entry name" value="Arg-tRNA-synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00456">
        <property type="entry name" value="argS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956:SF5">
        <property type="entry name" value="ARGININE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="ARGINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03485">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM01016">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arginyl tRNA synthetase N-terminal" evidence="16">
        <location>
            <begin position="79"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="DALR anticodon binding" evidence="15">
        <location>
            <begin position="536"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="6"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005009978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="662" mass="75668" checksum="7F4FB0E7D567C020" modified="2022-01-19" version="1">MMEARVAQAAARLERQENEIKSLTAEIEHLKNFGCLGVSPSLEGLRDENAKLKYRLSFLQKSLQEERNKTVKSMININSCLQEIFGAAIQAAYPELENPPLVVTPSQQPKFGDYQCNSAMGITQILLKTREQKVSPREIAEKITKHIPANECIEKVEIAGPGFINVHLRKDFVSKQLSSLLMNGVQPPAIGKRKRVILDFSSPNIAKEMHVGHLRSTIIGESMCRLFEFAGHDVLRLNHLGDWGTQFGMLIAHLQDRFPDYLSVSPPIGDLQAFYKESKRRFDTEEEFKKRAYQCVVLLQSKDPDFIKAWQLICDVSRKEFQKIYNCLDITLTERGESFYQDMMKDIIKEFEDKGFVQVDDGRKVVFVPGFSVPLTIMKSDGGYTYDTSDLAALRHRLLEEKGDILIYVVDSGQSVHLQTIFAAGQMIGWYDPKVTRITHAAFGVVLGEDKKKFKTRSGDTVRLTDLLEEGLKRAMDKLKDKERDKVLTPEELKAAQMSVAFGCIKYADLSHNRLNDYVFSFDKMLDDRGNTAAYLLYAFTRIRAIARLANIDEKMLRKAAREEVLVLDHEKEWKLGKCILRFPEILQKILDDLLLHTLCDYLYELATTFTEFYDNCYCVEKDRQSGQIVKVNMWRLLLCEATATVMAKGFDILGIKPVERM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TB03</accession>
    <name>A0A8C2TB03_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Interleukin-12 subunit beta</fullName>
            <shortName evidence="5">IL-12B</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Cytotoxic lymphocyte maturation factor 40 kDa subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">IL-12 subunit p40</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">IL12B</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="5">Heterodimer with IL12A; disulfide-linked. The heterodimer is known as interleukin IL-12.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the IL-12B family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TB03"/>
    <dbReference type="Ensembl" id="ENSCJPT00005014919.1">
        <property type="protein sequence ID" value="ENSCJPP00005010026.1"/>
        <property type="gene ID" value="ENSCJPG00005008776.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000012630"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043514">
        <property type="term" value="C:interleukin-12 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070743">
        <property type="term" value="C:interleukin-23 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004896">
        <property type="term" value="F:cytokine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042164">
        <property type="term" value="F:interleukin-12 alpha subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045519">
        <property type="term" value="F:interleukin-23 receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007259">
        <property type="term" value="P:cell surface receptor signaling pathway via JAK-STAT"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071222">
        <property type="term" value="P:cellular response to lipopolysaccharide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071346">
        <property type="term" value="P:cellular response to type II interferon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050829">
        <property type="term" value="P:defense response to Gram-negative bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042832">
        <property type="term" value="P:defense response to protozoan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TCB5</accession>
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        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
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            <taxon>Eukaryota</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
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        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="protein sequence ID" value="ENSCJPP00005010379.1"/>
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    </dbReference>
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        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 57"/>
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        </source>
    </evidence>
    <sequence length="1231" mass="141839" checksum="3CC82A6C1AA5A71C" modified="2022-01-19" version="1">MAEPEAAAEVEPVAVFGCRPGVSGGLCFLEEHLVLHAAGAACALFHTEHRWHKFIPGRDKSQGVRALAVSSSGRYMAVSETAEEEPTLTVYEMTAAPPRRRRTLTAAELPVREVAALAFSPDGRHLVALTEPPEAHLVLWLWEKQQLLAVLRLEDKGSGVCQVSFSPHDNTQICLTGNGFFKLYKYSERTLKQTNLQKGEPPNYLCHAWLSEGEIVCGTATGKLCLFETGELLWQIDVGYRKPPKELQEGKKDDESYSDVPSESTSEDSDSLQDIPPQISAVAAYSKGFACSTSPGVVLMFEKTNGNGAYKESQEIWLPQDLFTTVPKPLRRQDIICICFSPSEKTMVASTNKNQLYMFTMPTTDYLKEESSHFEYLHFPLHSAEVTGLDTCIRRPIVATCSVDKSVRVWNYKTNTLELYKEFWEEAYTVALHPTGLFCLVGFSDKLRFISLLYEGMNVFKDFPVRECKECSFSNGGHLFAAVNENVIQVYSCTTFENVNNLKGHSGKIRAVKWSTDDSKCFSCDTHGAVYEWNLSTGKREMECVTTSCIYSSIALHSDSKLVFAVGSDQTLKEISESSVQHEVPAFDAVYTAVAVSHSGDMVFVGTSLGTVRTMKYPLTLGREFNEYQGHSSAITKMSVTTDDLFLLTASEDGSLFFWKIYSKKGKMMKREKEFEYAEEVLIMKSDIEEKSRAMLDLQIRVSELQTENDYQLRLKDISYTEKIKELEETFTQELESLKNKHQNLQAEKANEETQHQLQLSELLNKHAKELRDLESDSNQKLMMENEKYQELQVTSQRMQEDYEKQMHNLQESKNKALEELTDYYEEKLNEKTLLLEEAEEDMRKQIEEDEDREIQDIKIKYERQLVEERESNMHLRGEVGVMNKRLSSLQKELKERNNDIEDLKVEQQNLLGVIKSLEKDISMLNSNIEQRTNTIQEKEKDIYDLKKKNQELEKFKFVLDHRIEQFKKQIESLENDIKIMKEQIQEMERELEQLHKENTQLKLNIAQLQQRLKATDNELHKERRKKQNMETLIKRFKMDLHNCVGFIQDYKKLKAGIRELYTKYVQQLETVEMEEIDTDLQQEYVRQREYLERNLAALKKRLAKDQETHQAAYMRIMQENVSLIKEINDLRQELTVAHAQVHDLQSALKLTKKKQAIQDTAPSIEVLPSPAVLRLNEQKENEKIIEMQLLEIQHLRDQIQEKGQGLEAQPLFHGMLPKLSLERSHKTHQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TCP8</accession>
    <name>A0A8C2TCP8_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ALF transcription elongation factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">AFF1</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AF4 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TCP8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005017071.1">
        <property type="protein sequence ID" value="ENSCJPP00005011698.1"/>
        <property type="gene ID" value="ENSCJPG00005010035.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182974"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032783">
        <property type="term" value="C:super elongation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007797">
        <property type="entry name" value="AF4/FMR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043640">
        <property type="entry name" value="AF4/FMR2_CHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043639">
        <property type="entry name" value="AF4_int"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10528">
        <property type="entry name" value="AF4/FMR2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10528:SF6">
        <property type="entry name" value="AF4_FMR2 FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05110">
        <property type="entry name" value="AF-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18875">
        <property type="entry name" value="AF4_int"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18876">
        <property type="entry name" value="AFF4_CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AF4/FMR2 C-terminal homology" evidence="6">
        <location>
            <begin position="939"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="121"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="376"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1077"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="166"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="222"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="414"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="455"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="468"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="614"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="720"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="743"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="774"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="812"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="845"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="859"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="884"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="900"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1107"/>
            <end position="1116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005011698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1200" mass="131809" checksum="0D2B0AC88C2D2C17" modified="2022-01-19" version="1">MAAQSSLYNEDRNLLRIQERQRRNQEALQEKDRFPENTPLFPEPYKTTKEDELSSRIQNMLGNYDDLQDLIINDRCHQNLIGIPEIDVPQIPQRKPSRPSFPEKTSCTLSSSFHHATRYPYMGPPVIAPPHPGHYAPHQKAQPGTGPAPGWHAKSHSSSSSWSQGQEHKRGRPDSHAGSHHNRTDRHPAGGGRAPEPQATLLELSPLLPSLSSPVAPLSPLHSIQHTNSKSQKSSKAHGPAYAQSPQDRAVGSRENKSQDNSAVVLAGTTQPSSQPFPPPLPSKTSAMQQKPTAYVRPMDGQEQAPVESPDLKPLLEEYHGEPYENISDLKANTKAKLTKLNISSEPTEQTLPSDSQCVEEILKEMTHSWPPLLTAIHTPSASEPSKFPFPTKESQHITSVAQNHKQYDAPSKTLPSSHPTISVLQEDLQLSDSEESGDDQVVERPPSSLDPPSALQSQPESVASAHSNSTESGSSSDSDSSSDSSETESSSSDSEANDPPRVSAPEPDPPISNKWQLDNWLTKVNPPAVPTESSSDTACSDGHEEDKEQPISNSSSCERVAPREPYDRNSIQTAQAPQDVHLPTQLGCQKSPVRTEEPSQRHTVGIKRPSKLPVHEEPKGGLKVESEPAPYEIREQTCREKPKPKTKSRPKSCDQKELKPQLQEAPKEKKHKSSHHANALLDHGPVRDVLEGSAQERPTLKHLPEGQDAAPTRTSGHRSAAEVKEGFHKGKLPVPTKEKKLVPPVSDVPGSPSLLVRIDLPLLSRVPQLPEKGNQKKRAEVREHPGIKGLDLEKKSTDTPDRSFKKRKREKEKDIDSKKRKLGKEAKSLQSSPNKDSCKLKAWNASSETQNKDLGQPLPLPPMSPTHPAPKPTKKAHKRPRSENGQPPATASSTALDTSNHKDPSSAKQKKMVENHSEQGSAGDVTNPLPVPSVPNGTSKPRRPQIKFEGQHLTEYYLEEAKKMKHEADAMVDKTGKAFQYLDAALSFVEYGMALESNAVAPKPAYSIFADTIDLLKYVMTLKPFTDVSASSHERVFAVLCMRCQSLLHMAMFRYKRDTAVKYSRILNDHFKSSSRVTQAPSPCVARSTGVPSPHSPVPSPARSMSSQQGSNGSNCGCNSVGSSVTIPSITSSYVNITSYVLYAYNIWEHADALSKNNKEFFAELSTAVCPLALTSSMAEMVHYTRQGLHWLRLNTSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TCQ3</accession>
    <name>A0A8C2TCQ3_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Matrix metalloproteinase-23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">MMP23B</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Protease. May regulate the surface expression of some potassium channels by retaining them in the endoplasmic reticulum.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="20">Can bind about 5 Ca(2+) ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="20">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M10A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015737693.1">
        <property type="nucleotide sequence ID" value="XM_015882207.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TCQ3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005017240.1">
        <property type="protein sequence ID" value="ENSCJPP00005011836.1"/>
        <property type="gene ID" value="ENSCJPG00005010117.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107323291"/>
    <dbReference type="KEGG" id="cjo:107323291"/>
    <dbReference type="CTD" id="8510"/>
    <dbReference type="GeneTree" id="ENSGT00940000161187"/>
    <dbReference type="OrthoDB" id="65569at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030574">
        <property type="term" value="P:collagen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04278">
        <property type="entry name" value="ZnMc_MMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000024">
        <property type="entry name" value="Matrix metallopeptidase 23B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000565">
        <property type="entry name" value="Matrix metalloproteinase-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033739">
        <property type="entry name" value="M10A_MMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001818">
        <property type="entry name" value="Pept_M10_metallopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021190">
        <property type="entry name" value="Pept_M10A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201">
        <property type="entry name" value="MATRIX METALLOPROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201:SF7">
        <property type="entry name" value="MATRIX METALLOPROTEINASE-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00413">
        <property type="entry name" value="Peptidase_M10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00138">
        <property type="entry name" value="MATRIXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="20" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="14 21" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="12 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9 20" id="KW-0862">Zinc</keyword>
    <keyword evidence="13" id="KW-0865">Zymogen</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="24">
        <location>
            <begin position="265"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="23">
        <location>
            <begin position="305"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="active site" evidence="19">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="180"/>
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        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
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        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="21">
        <location>
            <begin position="265"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00055848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00074039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005011836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="400" mass="45859" checksum="40BA713597EB6C1C" modified="2022-01-19" version="1">MDQIEQVSADRKKSFLSEDNKKSNGYRTVVGFLCIFPVVALLAIAGDPAGAAVQESQEETPSPGLRAVSASALHSPAFPPRPPARRKRYTITPGHLKWDHFNLTYKILSFPRNLINARDTRRGLAAAFRMWSEVSPFSFREVPRHLPSDLKIGFYSINHTDCLESLIHHCFDGTTGELAHAFFPPNGEIHFDDHEYWILGNTRFSWKKGVWLTDLVHVAAHEIGHALGLMHSQNPNALMHINATLTGKKTISQDEVWGIHRLYGCKDRLFMCPLWAQKGFCEKREKLMKKHCPFTCDFCYEFPFPTVPPTLPPPRTKTKTVSEGRNVTFRCGQKIIHKKGKVYWYKDKELLEYSYPGYLSLNEDHMSIIANAINEGTYTCIVKKKERILTTYSWRIRLRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TD26</accession>
    <name>A0A8C2TD26_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP-dependent DNA helicase PIF1</fullName>
            <ecNumber evidence="13">5.6.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">DNA 5'-3' helicase PIF1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">DNA repair and recombination helicase PIF1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 17" type="primary">PIF1</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer. Interacts with telomerase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the helicase family. PIF1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="13"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2TD26"/>
    <dbReference type="Ensembl" id="ENSCJPT00005015386.1">
        <property type="protein sequence ID" value="ENSCJPP00005010376.1"/>
        <property type="gene ID" value="ENSCJPG00005009044.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063561"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033678">
        <property type="term" value="F:5'-3' DNA/RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032211">
        <property type="term" value="P:negative regulation of telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001117">
        <property type="term" value="P:protein-DNA-RNA complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18037">
        <property type="entry name" value="DEXSc_Pif1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000805">
        <property type="entry name" value="ATP-dependent DNA helicase PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003367">
        <property type="entry name" value="ATP-dependent DNA helicase PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03176">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057437">
        <property type="entry name" value="PIF1/LRR1_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048293">
        <property type="entry name" value="PIF1_RRM3_pfh1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF7">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25344">
        <property type="entry name" value="PH_LRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 13" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9 13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIF1/LRR1 pleckstrin homology" evidence="16">
        <location>
            <begin position="5"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="14">
        <location>
            <begin position="180"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like 2B" evidence="15">
        <location>
            <begin position="436"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="DNA-binding region" evidence="13">
        <location>
            <begin position="550"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="201"/>
            <end position="208"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00065873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF21530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF25344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005010376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="610" mass="66838" checksum="E2CC995B089FAFC5" modified="2022-01-19" version="1">MGDAELRCTAVLERPLPGNAGTTRRVLRGATVLLGRDELRQPVLRVAGGGGEGSAASWVLSGDAVRLFTRFAGEGRAAVRVGPGGAQVLLSDCPPHALRRFLRIMKVKLAAGPRGAPRQPRLLHRPQPAFTVISPLQDRDMRPLRDRGGAERPAQVRPRVAKGELTWRVPRVERRPPARLSVEQEAVLGAVRSGKSVFFTGCAGTGKSFLLKKIVGSLPPNSTYATASTGVAACHIGGTTLHAFAGIGSGKAPLEQCIQLAERPGVRQHWLACQRLIIDEISMVDGKFFDKLEAVARAVRKRDEPFGGIQLIICGDFLQLPPVCKVNEETTFCFQAKSWRKCIHVNMELTEVRRQTDKTFISLLSAVRLGRCTDEVIRLLMQTATNRSECDGILATRLCTHKDDVELTNERRLRQLPGDLHTFEALDSDPMLVKLIDAQCPVGGRVELKVGAQVMLAKNLDVSQGLVNGARGVVVGFETEQKGLPKVRFLCGVTRVIKMERWLFKGPSGVHLSRQQLPLKLAWAISIHKSQGMSLDSVEISLSRVFESGQAYVALSRARSLAGLRVLDFDPKVVRADPTVLQFYRQLKRHQLQTQVNNIPVPAECLVQPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TD57</accession>
    <name>A0A8C2TD57_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">NAD-capped RNA hydrolase NUDT12</fullName>
            <ecNumber evidence="6">3.6.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">NADH pyrophosphatase NUDT12</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Nucleoside diphosphate-linked moiety X motif 12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="primary">NUDT12</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="28" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="28" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="21">mRNA decapping enzyme that specifically removes the nicotinamide adenine dinucleotide (NAD) cap from a subset of mRNAs by hydrolyzing the diphosphate linkage to produce nicotinamide mononucleotide (NMN) and 5' monophosphate mRNA. The NAD-cap is present at the 5'-end of some RNAs; in contrast to the canonical N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay. Preferentially acts on NAD-capped transcripts in response to nutrient stress. Also acts on free nicotinamide adenine dinucleotide molecules: hydrolyzes NAD(H) into NMN(H) and AMP, and NADPH into NMNH and 2',5'-ADP. May act to regulate the concentration of peroxisomal nicotinamide nucleotide cofactors required for oxidative metabolism in this organelle. Regulates the levels of circadian clock components PER1, PER2, PER3 and CRY2 in the liver.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>NAD(+) + H2O = beta-nicotinamide D-ribonucleotide + AMP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:11800"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.6.1.22"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:11801"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>NADH + H2O = reduced beta-nicotinamide D-ribonucleotide + AMP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48868"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90832"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.6.1.22"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:48869"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>NADPH + H2O = reduced beta-nicotinamide D-ribonucleotide + adenosine 2',5'-bisphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60820"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:90832"/>
            <dbReference type="ChEBI" id="CHEBI:194156"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:60821"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + beta-nicotinamide D-ribonucleotide + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60876"/>
            <dbReference type="Rhea" id="RHEA-COMP:15698"/>
            <dbReference type="Rhea" id="RHEA-COMP:15719"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:144029"/>
            <dbReference type="ChEBI" id="CHEBI:144051"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:60877"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="22">Homodimer. Homodimerization is essential for its catalytic activity and protein stability. Interacts (via ANK repeats) with BLMH.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasmic granule</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the Nudix hydrolase family. NudC subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.22" evidence="6"/>
    <dbReference type="RefSeq" id="XP_015704955.1">
        <property type="nucleotide sequence ID" value="XM_015849469.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015704956.1">
        <property type="nucleotide sequence ID" value="XM_015849470.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015704957.1">
        <property type="nucleotide sequence ID" value="XM_015849471.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015704958.1">
        <property type="nucleotide sequence ID" value="XM_015849472.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015704959.1">
        <property type="nucleotide sequence ID" value="XM_015849473.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032297252.1">
        <property type="nucleotide sequence ID" value="XM_032441361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TD57"/>
    <dbReference type="Ensembl" id="ENSCJPT00005016426.1">
        <property type="protein sequence ID" value="ENSCJPP00005011198.1"/>
        <property type="gene ID" value="ENSCJPG00005009661.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107306364"/>
    <dbReference type="KEGG" id="cjo:107306364"/>
    <dbReference type="CTD" id="83594"/>
    <dbReference type="GeneTree" id="ENSGT00940000157592"/>
    <dbReference type="OrthoDB" id="10249612at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome Z"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000210">
        <property type="term" value="F:NAD+ diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035529">
        <property type="term" value="F:NADH pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990174">
        <property type="term" value="F:phosphodiesterase decapping endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110153">
        <property type="term" value="F:RNA NAD-cap (NMN-forming) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032922">
        <property type="term" value="P:circadian regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110156">
        <property type="term" value="P:mRNA methylguanosine-cap decapping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019677">
        <property type="term" value="P:NAD+ catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110155">
        <property type="term" value="P:NAD-cap decapping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006742">
        <property type="term" value="P:NADP+ catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd03429">
        <property type="entry name" value="NUDIX_NADH_pyrophosphatase_Nudt13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000167">
        <property type="entry name" value="peroxisomal NADH pyrophosphatase NUDT12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000023">
        <property type="entry name" value="Peroxisomal NADH pyrophosphatase NUDT12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.20:FF:000002">
        <property type="entry name" value="Peroxisomal NADH pyrophosphatase NUDT12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050241">
        <property type="entry name" value="NAD-cap_RNA_hydrolase_NudC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015375">
        <property type="entry name" value="NADH_PPase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049734">
        <property type="entry name" value="NudC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015376">
        <property type="entry name" value="Znr_NADH_PPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001299">
        <property type="entry name" value="PRK00241.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42904:SF6">
        <property type="entry name" value="NAD-CAPPED RNA HYDROLASE NUDT12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42904">
        <property type="entry name" value="NUDIX HYDROLASE, NUDC SUBFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09296">
        <property type="entry name" value="NUDIX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09297">
        <property type="entry name" value="Zn_ribbon_NUD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 26" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-0521">NADP</keyword>
    <keyword evidence="16" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <feature type="repeat" description="ANK" evidence="26">
        <location>
            <begin position="45"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Nudix hydrolase" evidence="27">
        <location>
            <begin position="321"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00030313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00031178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00045837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00046702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00047501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00049196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00049264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005011198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="464" mass="51942" checksum="92016E8D817884C7" modified="2022-01-19" version="1">MTSFEKNFHQEMISQLHNFAAVGDTARLKALLSRSPSLINATSGNGWTALMYAARNGHFDVVRILLEGGCDRSIINKSRQTALDIAKFWGYKHIANLLSAAKGDQKPGFLPTEVKEYSNYFGMTLLDRRSDKRVDSKWLSKKQSHPATVYILFSDLSPLVTLNGGAEKSQQPEVRLCRLHHKDVEQCMSQTEEITLIFLGVDLHVHTNLLAAHNGKVLQEDDEDGLVAWFALSINPTSAERFKQKHEGCYFLHPPMPALLQLPENEAGVVAQARSVLAWHSRYRFCPTCGSATKIEEGGYKKTCVKEDCPSLQGVHNTSYPRVDPVVIMQVIHPDGNHCLLGRQKRFPPGMFTCLAGFVEPGETIEDAVRREVEEEAGVKVGHVQYVSCQPWPMPSSLMIGCLAVAVSTEIRVDKNEIEDARWFTREQVVDVLIKGNQRSFFVPPSRAIAHQLIKHWIGMNANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TEN0</accession>
    <name>A0A8C2TEN0_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aryl-hydrocarbon-interacting protein-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC107312484</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TEN0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005018259.1">
        <property type="protein sequence ID" value="ENSCJPP00005012629.1"/>
        <property type="gene ID" value="ENSCJPG00005010661.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000001289"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000052">
        <property type="entry name" value="Aryl-hydrocarbon-interacting protein-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039663">
        <property type="entry name" value="AIP/AIPL1/TTC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056277">
        <property type="entry name" value="PPIase_AIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11242">
        <property type="entry name" value="ARYL HYDROCARBON RECEPTOR INTERACTING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11242:SF1">
        <property type="entry name" value="PPIASE FKBP-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23322">
        <property type="entry name" value="PPIase_AIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="AIP/AIPL N-terminal FKBP-type PPIase" evidence="7">
        <location>
            <begin position="27"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="264"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="326"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="412"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="575"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="639"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="361"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="441"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="481"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="536"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="603"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005012629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="694" mass="77491" checksum="8E25D5BFD425E3AA" modified="2022-01-19" version="1">MEETYLLNVEGVRKKILHGGQGELPKFQDGSKITFHFQTLKDNFERTVIDDSREAGMPMEIIVGKMFKIEIWETLLCSMRTGEVAEFWCDAIHTGMYALVSKGMRRIAEGRDPLEGQKHRCGMGNMFDYHSTGYDDLDELQRTPQPLIFIMELFRVEEPSAYKRDTWAMSKEEKLAAVPVLHSEGNRLVLQKDFQRAAEKYQEAVICLRNLQAKEKPWEEGWLKLESLVTPLVLNYCQCQLELGEYYEVLEHTTELLQKHNDNAKAYFKRAKAHAAVWNEKEAREDFHRVAHLDPAMAAAVKKELKLLGERMRKKHVEDRKRYQGLFQQPRGGRAAMGGGQQEEGGSLVGEQATGMGEEGVGEREGGKDGDGCGKDERGRGAEPGEAEEVGNGVGQGGEIKLGACRAELESCGAERGLEEGEEEEEEEEDEEEEEEEDKEEEGKVMVEEEGKEMVKEEEVVKDAVEEEEEKTMEKEHEEEKETAEEEEEREETAEGEEEVREVEEEEKVEEVEAVVEEQEEKKEAVEEEEEGEGTVVREEEKEKIEEEENSAAEEEKLAVGQCEVSEKGELMLGQEAGGAEGAEAKSMAGEESGRAAEMAPTSLDQGTSQGQLEQGSCGEQQADNFPFTSLTNGAVLQARPSGADEELGGGTEVPSYLTPAEERDGAAPGVEEPLENCRESRELEATAMGHGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TGI7</accession>
    <name>A0A8C2TGI7_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FERM domain containing 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FRMD6</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TGI7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005019289.1">
        <property type="protein sequence ID" value="ENSCJPP00005013427.1"/>
        <property type="gene ID" value="ENSCJPG00005011319.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155517"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098592">
        <property type="term" value="C:cytoplasmic side of apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035332">
        <property type="term" value="P:positive regulation of hippo signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17198">
        <property type="entry name" value="FERM_F1_FRMD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000015">
        <property type="entry name" value="FERM domain-containing protein 6 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000079">
        <property type="entry name" value="Putative FERM domain-containing protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018979">
        <property type="entry name" value="FERM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018980">
        <property type="entry name" value="FERM_PH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047145">
        <property type="entry name" value="FRMD6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13429">
        <property type="entry name" value="FERM DOMAIN (PROTEIN4.1-EZRIN-RADIXIN-MOESIN) FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13429:SF11">
        <property type="entry name" value="FERM DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09380">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09379">
        <property type="entry name" value="FERM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01196">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FERM" evidence="2">
        <location>
            <begin position="16"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="345"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005013427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="575" mass="65596" checksum="4711AC35885A6BBA" modified="2022-01-19" version="1">MNKLPFHNNRVMQDRRSVCIFLPNDDSLNIIINVKILCHELLVQVCDLLRLKDCHLFGLSVIQNNEHVYMDLAQKLYKYCPKEWKKEASKVSGEGIDQFGPPMIIHFRVQYYVENGRLISDRTARYYYYWHLRKQVLHSQCVLREEAYFLLTAFALQADLGDFKRNKHYGKYFEPEAYFPAWVVAKRGRDYILKHIPNMHKDQFALTASEAHLKYIKEAVRLDDVAVHYYRLYKDKREVDASLTLGLTTRGIQIFQNLDEEKQLLYDFPWTNVGKLVFVGKKFEILPDGLSSHRLYMNLQPVLRQVRSSTVSRTSSDIRWTWTWDQLEKRSRASGSQAPAASGTSACSRHSNHSHSSSHTSGIEADPKPRDMGPEDAGVHRKLKTCSSMTSHGSSHTSAWRVGKDRLGGSIEMLVDDPRELERAGELALEVSPDMCVYITEDMLLSRKFNGHSGLIVKELSSSTSSSSETVVKLRGQHRLLTPGGKPKTSTDRHSLSLDDIRLYQKDFLQLADLCQDTAQSFTFGCSHGLGDDGLYCNGCLARQCLNIQEGFPANGPAKYFSLDLTHDEVPEFVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TGJ7</accession>
    <name>A0A8C2TGJ7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA transcription, translation and transport factor protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">RTRAF</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RTRAF family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015721446.1">
        <property type="nucleotide sequence ID" value="XM_015865960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TGJ7"/>
    <dbReference type="SMR" id="A0A8C2TGJ7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005019302.1">
        <property type="protein sequence ID" value="ENSCJPP00005013439.1"/>
        <property type="gene ID" value="ENSCJPG00005011331.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107315521"/>
    <dbReference type="KEGG" id="cjo:107315521"/>
    <dbReference type="CTD" id="51637"/>
    <dbReference type="GeneTree" id="ENSGT00390000005163"/>
    <dbReference type="OrthoDB" id="514167at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072669">
        <property type="term" value="C:tRNA-splicing ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019265">
        <property type="entry name" value="RTRAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15924">
        <property type="entry name" value="CLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10036">
        <property type="entry name" value="RLL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005013439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="244" mass="28020" checksum="812E7DF775AD926F" modified="2022-01-19" version="1">MFRRKLSALDYHNPGGFNCRDETEFRNFIVWLEDQKIRHYKIEDRGNLRNIHSDDWPKSFEKYMKDVNCPFKMQERQETVDWLLGLAVRLEYGDNADKYKDSTPDGAKNTDNTAKNAEPLINLDVNNPDFKAGVMALANLLQIQRHDDYLVMLKAIRILVQERLTQDAIAKANQSKEGLPVALEKHILGFDTGDAVINEAAQILRLLHIEELRELQTKINEAIVAVQAIIADPKTDHRLGKVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2THM4</accession>
    <name>A0A8C2THM4_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UPAR/Ly6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2THM4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005017875.1">
        <property type="protein sequence ID" value="ENSCJPP00005012320.1"/>
        <property type="gene ID" value="ENSCJPG00005010480.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00960000189320"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030550">
        <property type="term" value="F:acetylcholine receptor inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23543">
        <property type="entry name" value="TFP_LU_ECD_Ly6E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.60.10:FF:000003">
        <property type="entry name" value="lymphocyte antigen 6E isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.60.10">
        <property type="entry name" value="CD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051110">
        <property type="entry name" value="Ly-6/neurotoxin-like_GPI-ap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016054">
        <property type="entry name" value="LY6_UPA_recep-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035076">
        <property type="entry name" value="Toxin/TOLIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16983:SF13">
        <property type="entry name" value="LYMPHOCYTE ANTIGEN 6E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16983">
        <property type="entry name" value="UPAR/LY6 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00087">
        <property type="entry name" value="Toxin_TOLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00134">
        <property type="entry name" value="LU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="UPAR/Ly6" evidence="6">
        <location>
            <begin position="27"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005012320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="121" mass="13588" checksum="015CFEC5F0E4F214" modified="2022-01-19" version="1">MQSFVLWLRDTQPWLPILISRSSRRWEQSNWSCLKAKKCSDEDEYCVTNVAAVGIGSLSFWKRITKKCSKTCPYHNFSLGLATYTSFCCQTFLCNLPACPGPRLGMCLSRGELVSCSSIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TIB5</accession>
    <name>A0A8C2TIB5_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Solute carrier family 22 member 18-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC107314710</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TIB5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005018302.1">
        <property type="protein sequence ID" value="ENSCJPP00005012670.1"/>
        <property type="gene ID" value="ENSCJPG00005010756.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160333"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24002">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24002:SF3">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005012670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="295" mass="32212" checksum="0BADDFFD4631D425" modified="2022-01-19" version="1">MQCCSSTGVLQPKGQQLKLGSFPCQPKTGTAEDPSKATPTEAHEFSRRKQSGNDLIRFPLIFFFPSPSSKAGRENVAWHTCVLLCCVCAGGSTATSQGRPTVTQALLVPREWGSCYCFMHEGREEAEQSSILDPYLVVQGLVIGKLTSHCTEQTLLRFSILLFAGVGLGMALMRTVWHYCIIVVPLVFAFNVQGTITDSILTKAVSSSDTGAMLGICASVQPLTRTVGPTLGVILYRQFGVSSFGYLQLIVNAGLFVYLLKRKSPLRETKSHYFTKAASFFFSTEIKKVTLLCIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TJ46</accession>
    <name>A0A8C2TJ46_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Progestin and adipoQ receptor family member 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">PAQR9</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ADIPOR family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TJ46"/>
    <dbReference type="Ensembl" id="ENSCJPT00005019395.1">
        <property type="protein sequence ID" value="ENSCJPP00005013509.1"/>
        <property type="gene ID" value="ENSCJPG00005011390.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162334"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF143">
        <property type="entry name" value="MEMBRANE PROGESTIN RECEPTOR EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005013509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="376" mass="42035" checksum="7A8F4323E2A0A734" modified="2022-01-19" version="1">MTPARGHRRLRATSRGTARPAGVTVLFAVPSEAAPPARPAALLRWDEVPEDFVECFILSGYRRLHCSAQECLASVLQPTNETLNFWTHFIPLLLFLSRFGRLLLLRGAGDVPFHHPALLPLWCYASGVLLTFAMSCTAHLFSCLSPRLRAAFFYLDYASISYYGFASTVAYSYYLLPGLSLLDAGVLSRYVQQQLGWQLDCSLPIAAYRALVLPVALALAVGCTAACCRSRAACCAYPFAVRTFVFAMPLSMACPIMLESLIFDLRTRNPTLFVYFYRRYFWLLVAAFFNVSKIPERIQPGLFDIVGHSHQLFHIFTFLSIYDQVHYVEDGLAEFLKAAPAAPTYLGTVGYMLLLTVCLAVVVRRFLNVADLCKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TJF2</accession>
    <name>A0A8C2TJF2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial assembly of ribosomal large subunit protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MALSU1</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Required for normal mitochondrial ribosome function and mitochondrial translation. May play a role in ribosome biogenesis by preventing premature association of the 28S and 39S ribosomal subunits. Interacts with mitochondrial ribosomal protein uL14m (MRPL14), probably blocking formation of intersubunit bridge B8, preventing association of the 28S and 39S ribosomal subunits. Addition to isolated mitochondrial ribosomal subunits partially inhibits translation, probably by interfering with the association of the 28S and 39S ribosomal subunits and the formation of functional ribosomes. May also participate in the assembly and/or regulation of the stability of the large subunit of the mitochondrial ribosome. May function as a ribosomal silencing factor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Iojap/RsfS family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TJF2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005020582.1">
        <property type="protein sequence ID" value="ENSCJPP00005014462.1"/>
        <property type="gene ID" value="ENSCJPG00005012072.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000015035"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140978">
        <property type="term" value="F:mitochondrial large ribosomal subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070130">
        <property type="term" value="P:negative regulation of mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090071">
        <property type="term" value="P:negative regulation of ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000018">
        <property type="entry name" value="Mitochondrial assembly of ribosomal large subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01477">
        <property type="entry name" value="Iojap_RsfS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004394">
        <property type="entry name" value="Iojap/RsfS/C7orf30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00090">
        <property type="entry name" value="rsfS_iojap_ybeB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21043">
        <property type="entry name" value="IOJAP SUPERFAMILY ORTHOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21043:SF0">
        <property type="entry name" value="MITOCHONDRIAL ASSEMBLY OF RIBOSOMAL LARGE SUBUNIT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02410">
        <property type="entry name" value="RsfS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00053669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00073331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005014462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="256" mass="28391" checksum="8456654E2E81B545" modified="2022-01-19" version="1">MPAGRSAQLPSQRGGSIPPPLHHSLHTQPRTLRLAPGVSADRQQDKPIVRRVPDNLCTAAGPGAGRRTVGMWRALLGGCRVVRARSALPVVGAAAVRGTGGGGMAATAAEWRQETVPDTPLPKFNIDFVVKLLRQENAKDICVIRVPPEIKYCHYFIVVSGSSTRHLHAMAHYMLKMYKHQKEESDPHTRIEGKETDDWLCIDFGSIVVHFMLPETRETYELEKLWTLGPYDDQLAQMTPQSLPEDFILGLTSEQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TJT0</accession>
    <name>A0A8C2TJT0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Ovotransferrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">MELTF</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Involved in iron cellular uptake. Seems to be internalized and then recycled back to the cell membrane. Binds a single atom of iron per subunit. Could also bind zinc.</text>
    </comment>
    <comment type="subunit">
        <text evidence="17">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the transferrin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015727137.1">
        <property type="nucleotide sequence ID" value="XM_015871651.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TJT0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005021310.1">
        <property type="protein sequence ID" value="ENSCJPP00005014987.1"/>
        <property type="gene ID" value="ENSCJPG00005012469.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107318158"/>
    <dbReference type="KEGG" id="cjo:107318158"/>
    <dbReference type="CTD" id="4241"/>
    <dbReference type="GeneTree" id="ENSGT00940000159265"/>
    <dbReference type="OrthoDB" id="9981115at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900025">
        <property type="term" value="P:negative regulation of substrate adhesion-dependent cell spreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090091">
        <property type="term" value="P:positive regulation of extracellular matrix disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010756">
        <property type="term" value="P:positive regulation of plasminogen activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000108">
        <property type="entry name" value="melanotransferrin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016357">
        <property type="entry name" value="Transferrin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001156">
        <property type="entry name" value="Transferrin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018195">
        <property type="entry name" value="Transferrin_Fe_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11485:SF21">
        <property type="entry name" value="MELANOTRANSFERRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11485">
        <property type="entry name" value="TRANSFERRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00405">
        <property type="entry name" value="Transferrin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002549">
        <property type="entry name" value="Transferrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00422">
        <property type="entry name" value="TRANSFERRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00094">
        <property type="entry name" value="TR_FER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00205">
        <property type="entry name" value="TRANSFERRIN_LIKE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00206">
        <property type="entry name" value="TRANSFERRIN_LIKE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00207">
        <property type="entry name" value="TRANSFERRIN_LIKE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51408">
        <property type="entry name" value="TRANSFERRIN_LIKE_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13 20" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="11 17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 17 19" id="KW-0408">Iron</keyword>
    <keyword evidence="4 17" id="KW-0410">Iron transport</keyword>
    <keyword evidence="15" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 17 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="17" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 21" id="KW-0732">Signal</keyword>
    <keyword evidence="2 17" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034770345" description="Ovotransferrin" evidence="21">
        <location>
            <begin position="19"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="domain" description="Transferrin-like" evidence="22">
        <location>
            <begin position="22"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Transferrin-like" evidence="22">
        <location>
            <begin position="365"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>hydrogencarbonate</name>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>hydrogencarbonate</name>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>hydrogencarbonate</name>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>hydrogencarbonate</name>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="477"/>
        </location>
        <ligand>
            <name>hydrogencarbonate</name>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="481"/>
        </location>
        <ligand>
            <name>hydrogencarbonate</name>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="483"/>
        </location>
        <ligand>
            <name>hydrogencarbonate</name>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="484"/>
        </location>
        <ligand>
            <name>hydrogencarbonate</name>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <label>2</label>
        </ligand>
    </feature>
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        <location>
            <position position="555"/>
        </location>
        <ligand>
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="25"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
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            <end position="215"/>
        </location>
    </feature>
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            <end position="188"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
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            <begin position="185"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
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            <begin position="475"/>
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
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            <begin position="531"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="602"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TNE6</accession>
    <name>A0A8C2TNE6_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Coiled-coil domain containing 9B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">CCDC9B</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015718758.1">
        <property type="nucleotide sequence ID" value="XM_015863272.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TNE6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005023156.1">
        <property type="protein sequence ID" value="ENSCJPP00005016477.1"/>
        <property type="gene ID" value="ENSCJPG00005013536.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107314225"/>
    <dbReference type="CTD" id="388115"/>
    <dbReference type="GeneTree" id="ENSGT00530000063950"/>
    <dbReference type="OrthoDB" id="10058133at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029336">
        <property type="entry name" value="DUF4594"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15635">
        <property type="entry name" value="COILED-COIL DOMAIN CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15635:SF10">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 9B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15266">
        <property type="entry name" value="DUF4594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="50"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="133"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="179"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="275"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="181"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="292"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="332"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="411"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="464"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="522"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="561"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="592"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005016477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="617" mass="68804" checksum="0821045400EE5734" modified="2022-01-19" version="1">MSDMHRADATVDDAVLRKKEQKDVELDKKILALRKKNEALIRRYQEIEEDKKRAEQEGMAVTSRKPKQDGLTITITKAHNDKRVVSEKKSPGPVSTGFGIGSEEEEEEEEEADHMFTFRMGKRMQLAVTMDNKAKGKRIVSEKRTECFPGPGRMPDLSEEETDHLVAVRRGRRMQIAITMDNKEKIEERRTVEKRRSDSDRGPESEHGRKEGGKSVQKCLGDLSFPLSGRERSEYIRWKRERDQIDLERLARHKNAKGEWRRAWDVEKSEHMFEEDFVKDGEPALDNPSNKKGGRNARKFQHRSFPSNGRGAGQHSVNVSDPGPKATSSRAKGKDRLTGRARRWDAKEGEDTSFLKDEPDSQRNLGTDKQKSKGEEVVEENCPAELEEKVKPSNLQEPGRRSGKAWPAHSGQKEERRRVKGLSKEVSEASTGDLELRSKASEELIEEDANGKPGTADIPQENESTNSSASQSGLSSAVQATKHNSEETLLLPVGAELDGGGLEKKTASEQESTEDSSNSHGGKMDTDAGDRLDADQGQLVGKRGEEVAQNTALEGQTLALKRVEDAEDTQHTGEPLPTEKNNSNGTVIPEQDVAKRQSREGDQPEDGKDKDSGDTLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TNW3</accession>
    <name>A0A8C2TNW3_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TNW3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005023394.1">
        <property type="protein sequence ID" value="ENSCJPP00005016681.1"/>
        <property type="gene ID" value="ENSCJPG00005013684.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162399"/>
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        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1930">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050473">
        <property type="entry name" value="A2M/Complement_sys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041555">
        <property type="entry name" value="MG3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040839">
        <property type="entry name" value="MG4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412:SF139">
        <property type="entry name" value="C3 AND PZP-LIKE ALPHA-2-MACROGLOBULIN DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412">
        <property type="entry name" value="MACROGLOBULIN / COMPLEMENT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MG3"/>
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    </dbReference>
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        <property type="entry name" value="MG4"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034919068" description="C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8" evidence="1">
        <location>
            <begin position="23"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Macroglobulin" evidence="3">
        <location>
            <begin position="200"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Macroglobulin" evidence="2">
        <location>
            <begin position="328"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005016681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="479" mass="53985" checksum="98D2688242F91B7C" modified="2022-01-19" version="1">MRRAERRCAWGVLLTLCGLSAAQPRGRGYLIAAPSVFRSGVEEAVSVTIFNAVKETTVQIQLVVKGETVSRGHGTVLDKGTIKLKVPSGLRGQGHLKVWGNRHVTEEGYIFHNYTTVTIDSKGSSVFIQTDKPVYKPKQKGNVASENLSGAGARVHSTWLSFSGMVNMSFPLSDQPVFGEWLIFAEMQGHTYNKSFEVQKYVLPKFELLIDPPRYIRDLTMCEKGTVHARYTFGKPVTGKLIVNMTINGVGYYRHEVGHPVLKTTQIDGSAVFDVCVKDMMPADVPEHFRGTVNIWATVISSDGSKQVTFDDSTPVQKQLIDIKYSKDTRKQFKPGLPYKGKVEVTYPDGSPADRVTIRIKAELTPKDNVYTSELVSRNGLVEFEIPSIPTAAQYVWLEVFKELAEYDVSDAFGALKEEGHFWWPGMSSRRRRRSSVFPWHWDVTKDARFAFTVGRNRLGCNDRYSQLKPQAEWRHVHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TPY3</accession>
    <name>A0A8C2TPY3_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 17">Exonuclease 1</fullName>
            <ecNumber evidence="17">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">EXO1</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">5'-&gt;3' double-stranded DNA exonuclease which may also contain a cryptic 3'-&gt;5' double-stranded DNA exonuclease activity. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for DNA mismatch repair (MMR).</text>
    </comment>
    <comment type="function">
        <text evidence="17">5'-&gt;3' double-stranded DNA exonuclease which may also possess a cryptic 3'-&gt;5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="17">Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="17"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2TPY3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005023664.1">
        <property type="protein sequence ID" value="ENSCJPP00005016914.1"/>
        <property type="gene ID" value="ENSCJPG00005013858.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00510000047676"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051908">
        <property type="term" value="F:double-stranded DNA 5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045145">
        <property type="term" value="F:single-stranded DNA 5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110025">
        <property type="term" value="P:DNA strand resection involved in replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002455">
        <property type="term" value="P:humoral immune response mediated by circulating immunoglobulin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045190">
        <property type="term" value="P:isotype switching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016446">
        <property type="term" value="P:somatic hypermutation of immunoglobulin genes"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd09908">
        <property type="entry name" value="H3TH_EXO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09857">
        <property type="entry name" value="PIN_EXO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000011">
        <property type="entry name" value="exonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000096">
        <property type="entry name" value="Exonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037315">
        <property type="entry name" value="EXO1_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044752">
        <property type="entry name" value="PIN-like_EXO1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF8">
        <property type="entry name" value="EXONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00842">
        <property type="entry name" value="XPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 17" id="KW-0228">DNA excision</keyword>
    <keyword evidence="14 17" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13 17" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="12 17" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="10 17" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="9 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 17" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15 17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG-I" evidence="19">
        <location>
            <begin position="79"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="382"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="476"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="541"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="391"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="541"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00055562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU910737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005016914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="741" mass="82684" checksum="5F12A347759552D5" modified="2022-01-19" version="1">MKLVEMLLSFGIKPILVFDGCTLPSKKEVEKARREKRQANLLKGKQLFREGKFSEARDCFARSVNVTHAMAHEVIKAARARGVDCIVAPYEADAQLAYLNKAGVVQAIITEDSDLLAFGCKKVFLKIDKFGNGLEIDQARLGNCKQLGNVFTEEKFRYMCILSGCDYLSSIHGIGLAKACKLLKLANNPDIIKVIKKIGHYLKMNITVSEEYIQGFTRANNTFLYQLVFDPIKRKLVPLNDYAADIDPETLIYAGRHFGDSTGFQVALGNIDIDTMEQIDNYNPDTAQPTQQRSRGWNDKCANHVNSIWSKDYKLGPSMDDAPHTTHVPEKSTTKGIEKIISIKGLKLPGKELFTKRQRSDLEELSDGDLLNQYSFSKAKKFKESGEDGQSQKSISAIQSIDSSENSVIKESSNSLPRVRNKFASFLQRKNKQTDAVIVPGTRSRFFCNDADTLGFKAKDDSDIIQDVEEDCKQQEVEHVTEDESPILETEKSKTISSLPGERPKSCFQWLSILGNHSGNPGPSHTVLSQQFHQQRSNCMASQADDSNGVQTESGAMCSESDEESSPLIEPQCFSQSQKSVEPSECNLGSSKILKESDSNSKLLDNQCTQRSPVFSAVQTDRKNTVAKIKVPGLRKSSSAGSHIVTKLKPLIPAKVSGLSKKLSPVQKRNHCDAENKLGLQTTIGELWRNFQFKRDYEKLPSCKKSDPLSPIKDNIQLTPETEEEVFNHLEHSHVQRAIFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TSK2</accession>
    <name>A0A8C2TSK2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chromodomain Y-like protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">CDYL2</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">Interacts (via chromo domain) with histone H3K9me3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015729603.1">
        <property type="nucleotide sequence ID" value="XM_015874117.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TSK2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005025136.1">
        <property type="protein sequence ID" value="ENSCJPP00005018067.1"/>
        <property type="gene ID" value="ENSCJPG00005014692.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107319372"/>
    <dbReference type="KEGG" id="cjo:107319372"/>
    <dbReference type="CTD" id="124359"/>
    <dbReference type="GeneTree" id="ENSGT00940000159646"/>
    <dbReference type="OrthoDB" id="6357915at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18634">
        <property type="entry name" value="CD_CDY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.40:FF:000018">
        <property type="entry name" value="Chromodomain Y like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000012">
        <property type="entry name" value="Chromodomain Y-like protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051053">
        <property type="entry name" value="ECH/Chromodomain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684:SF2">
        <property type="entry name" value="CHROMODOMAIN Y-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="6">
        <location>
            <begin position="7"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="62"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00063797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00067127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005018067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="507" mass="56998" checksum="DBA7B9E58B2FD4B9" modified="2022-01-19" version="1">MASGDLYEVERIVDKRKNKKGKWEYLIRWKGYGSNEDTWEPEHHLLHCEEFIDEFNGLHVSREKRSRHGKQTSTTKFLRENRGSSLEKISHRPSESGKAKGSAHKRKRINPSLQKQKRGYTAKPASANDRAAKTVTYRTTPSGLQIMPLKKPQNGLQNGDGSHEKDSRHFGNGSQQQNVDINDHEGEQNLPSVLEVSNESPVVNGIGSSLANGSLNLHSTVKRKLDGEKDYVFDKRLRYSVRQNESNCRFRDIVVRKEDGFTHILLSSQTSDNNALTPEIMKEVRRALCNASADDSKLLLLSAVGSVFCSGLDYSYLIGRLSNDRRKESTRIAEAIRDFVKAFIQFKKPIVVAINGPALGLGASILPLCDIVWASEKAWFQTPYATIRLTPAGCSSYTFPQILGVALANEMLFCGRKLTAQEACSRGLVSQVFWPTTFSQEVMLRVKEMASCSAVVLEESKCLMRSFLKSGLEDVNEKECQMLKQLWSSSKGLDSLFSYLQDKIYEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TSW7</accession>
    <name>A0A8C2TSW7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Polypeptide N-acetylgalactosaminyltransferase</fullName>
            <ecNumber evidence="19">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Protein-UDP acetylgalactosaminyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">GALNT16</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = a 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23956"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:12788"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:53604"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:67138"/>
            <dbReference type="EC" id="2.4.1.41"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = a 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52424"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:67138"/>
            <dbReference type="ChEBI" id="CHEBI:87075"/>
            <dbReference type="EC" id="2.4.1.41"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 19">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 19">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 19">Golgi apparatus membrane</location>
            <topology evidence="2 19">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 19">Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="19"/>
    <dbReference type="RefSeq" id="XP_015720196.1">
        <property type="nucleotide sequence ID" value="XM_015864710.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TSW7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005025639.1">
        <property type="protein sequence ID" value="ENSCJPP00005018409.1"/>
        <property type="gene ID" value="ENSCJPG00005014992.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107314903"/>
    <dbReference type="KEGG" id="cjo:107314903"/>
    <dbReference type="CTD" id="57452"/>
    <dbReference type="GeneTree" id="ENSGT00940000158846"/>
    <dbReference type="OrthoDB" id="429263at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004653">
        <property type="term" value="F:polypeptide N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23479">
        <property type="entry name" value="beta-trefoil_Ricin_GALNT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02510">
        <property type="entry name" value="pp-GalNAc-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000041">
        <property type="entry name" value="Polypeptide N-acetylgalactosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000020">
        <property type="entry name" value="Polypeptide N-acetylgalactosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045885">
        <property type="entry name" value="GalNAc-T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675:SF3">
        <property type="entry name" value="POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 19" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 19" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12 19" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 19" id="KW-0430">Lectin</keyword>
    <keyword evidence="15 19" id="KW-0464">Manganese</keyword>
    <keyword evidence="13 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="21">
        <location>
            <begin position="436"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="32"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00050905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00052209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00060317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU361242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM00458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005018409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="563" mass="63959" checksum="043ECD0456FCA1D1" modified="2022-01-19" version="1">MRRIRANAIAILTAAWILGTFYYLWQDGKPRSATAGGSGRGGQRAAGRPEARREESAVPLGVTRAPQGEKNSRRAFDEKAYLSSKLLKAGEDPYRQHAFNQLESDKLSSDRPIRDTRHYRCTSVRYDTDLPATSLIITFHNEARSALLRTVRSVLNRTPPNLIQEIILVDDFSSDPEDCQLLTKIPKVKCLRNIRREGLIRSRVRGAEVATADILTFLDSHCEVNSEWLQPMLQRVKEDYTRVVSPIIDVISLDNFAYLAASADLRGGFDWSLHFKWEQIPIEQKMSRTDPTQSIRTPVIAGGIFVINKSWFNHLGKYDTQMDIWGGENFELSFRVWMCGGSLEIVPCSRVGHVFRKRHPYDFPEGNALTYIKNTKRTAEVWMDEYKQYYYEARPSAIGKSYGSIADRVEQRRKLNCKSFQWYLEKVYPELKVPEKDLIPGIIRQGGNCLESWAQDTSGNTLVGIGNCKGTVNNPPVTQEWVFSDPVIRQQDKCLSITSFSTGSQITLEACNQKDGRQKWKMKGSFIQHFVSGLCLENQTGRVVTNPCQADVPGQQWELLQAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TWY7</accession>
    <name>A0A8C2TWY7_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Coiled-coil domain containing 157</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">CCDC157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TWY7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005025373.1">
        <property type="protein sequence ID" value="ENSCJPP00005018219.1"/>
        <property type="gene ID" value="ENSCJPG00005014845.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000013684"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029681">
        <property type="entry name" value="CCDC157"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43696">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43696:SF9">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="616"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="684"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="616"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005018219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="707" mass="78366" checksum="18CB4610892C8897" modified="2022-01-19" version="1">MAHLLGHPGCMASLQADLRDLQGAIADVTSRTGPARFPSWKFPNKVSCELDLLALLERYSHAEGDPEFSQHAHVVLLELVIDRLLLLLQSFTGYAENLLSERTVPPAEAVGPCMSAGLTVRRYWHSMLRLGACYQQLQTEKKTCRKDIAALQSTPEAERTAKESSSEPSTPSGAAQPSSLWQVVSNTAGSSQPSSACSPVERSRSISTQTAEPPAPCDSCASAQAGLQEVSKAIISICQSQNIPSALSSALEGTEGRRTLSATDVSYWISEQSKDLSHISTHLHTLLEQVNPLKSELAESKKEKDELQKQVEDFARLLQVEKETQAQQRKEAEQSLEAKNKERLEAVARLEQDKDDLRRGAALLEEQISALKEAVGTKQAAVQELEATKQTLLEDLKTAMVARSRVLELEEEVQLLISQRDSLEQELSAVTTQLEKEKAKVESTLRHEKSLQAKQSTLLQQLDSLDQQREELQASLGEAEEERARMAEQLQESQKQKEQSMHQLRVQQELLDTLQQEKLRLEQSISELRENVSGLEEQAKELKEREKLLVFFPELHIPVETQFESTGNVTEDMEKQLQANHIRIGVLEQENMRLRAALAKVKAAAQQGVLQHIPQTQQWTQLSSQREGEAAGPPSSQGSGDGKGLYRATSKARQRPVGSQQHKLLPTEPAREARACITLPAEGLVLAPHKPRGSSSAPRAHHFSHRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TXB9</accession>
    <name>A0A8C2TXB9_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cingulin like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">CGNL1</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TXB9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005027770.1">
        <property type="protein sequence ID" value="ENSCJPP00005020109.1"/>
        <property type="gene ID" value="ENSCJPG00005016235.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154489"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051058">
        <property type="term" value="P:negative regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051497">
        <property type="term" value="P:negative regulation of stress fiber assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0150105">
        <property type="term" value="P:protein localization to cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1000">
        <property type="entry name" value="arf6 gtpase in complex with a specific effector, jip4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002928">
        <property type="entry name" value="Myosin_tail"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46349:SF2">
        <property type="entry name" value="CINGULIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46349">
        <property type="entry name" value="CINGULIN-LIKE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01576">
        <property type="entry name" value="Myosin_tail_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin tail" evidence="4">
        <location>
            <begin position="588"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="245"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="360"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="467"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="591"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1052"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="266"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="361"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="374"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="467"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005020109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1093" mass="125509" checksum="F56A84A401E2370A" modified="2022-01-19" version="1">MEPYFAGYKPQDYEVTLELASEEIQKNRNGQNSKTGSYGVSIRVQGIDGHPYIVLNNTEGCLSENPPPSGKEHQVISQTINQSITDSNAAFKLEDKNSELTDFPGTQHVQPCTFKSLKITNPDENESGISDFKDGALKSSNLLNFQRHPELLRPYDPEKNNLNLEICQSSVCSKSTSFANEDKTEVKPWISSSKVISLQKTNAYLAESTKANSKKIHLNRTVGIEDQNKQVLDCPGSIISPNEVGVSESFSSTGKSPCLSPAAYPETRKPRPDVLPFRRQDSSGPVLDSRRSSSSSATPTSANSLYRFLLDDQEYAIYADNVNRHENRRYIPFLPGTGRDIDTGSLPGVDQLIEKFDKKVESHKRGRPGKRNRIHPDDRKRSRSVDSALSLELDMNSDYLGEVSKSLGKSTEHLLKPSEVCFQKQLSRDQKPPSKEMKISARSIGKLQMPDKDSQNSHFSSLQHLKQNGDNTESFTFRSSTLPGQKKREEAKTVTSTLLLPNRITVPPDSGAKKISLKTFSSVPNIQATPDLLKGQQDVAHQTNEETAKQILYNYLKEGSTDNDDATKRKVNLVFEKIQTLKSRAAGKTQVSDTSAEVKALMEQKTELERKVEELQKKLDLEITNQQNCKEERDATRASLQDLQLQLDESISEKDALKKKLEENEKELRQNLEELFQVKIEQEKHQTEIRDLQDQLSEMHDELDNAKHTDEREKEVLIEELMQMKQDLQEILIAKDQQEEILRKRERELTALKGALKEEVSSHDMEMDKLKEQHDKEMLNLQQSLEKATENAAVLASERDAVEEVRSSIENEVKKLTEANTQLKRTVDELETKNEELQRHFDNMKGEENSMKEKLKRYKDENERLEEALKYAEKEAKELMALKTSLENQLGAMQESIRCISQERQQLTEQLKDETHQKEQLEKIKNEMENERWQLNKTVEKLQEEMSEMVEASRTSTVELQNQLDEYKEKNRRELADVQRQLKEKILEVEKSRLTTIRMQDEMRLLEENLRDHQRAQDEAITKTQLLEQTVKGLEYELEAKNHLKDDRARQIKLMEDKLSHLELELDEEKNNSDLLSERISRCREQVLRELFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TY92</accession>
    <name>A0A8C2TY92_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GDP-mannose 4,6 dehydratase</fullName>
            <ecNumber evidence="4">4.2.1.47</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">GDP-D-mannose dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">GMDS</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GDP-alpha-D-mannose = GDP-4-dehydro-alpha-D-rhamnose + H2O</text>
            <dbReference type="Rhea" id="RHEA:23820"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:57964"/>
            <dbReference type="EC" id="4.2.1.47"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:23821"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; GDP-L-fucose biosynthesis via de novo pathway; GDP-L-fucose from GDP-alpha-D-mannose: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.47" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2TY92"/>
    <dbReference type="Ensembl" id="ENSCJPT00005026666.1">
        <property type="protein sequence ID" value="ENSCJPP00005019218.1"/>
        <property type="gene ID" value="ENSCJPG00005015622.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00440000033640"/>
    <dbReference type="UniPathway" id="UPA00128">
        <property type="reaction ID" value="UER00190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008446">
        <property type="term" value="F:GDP-mannose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070401">
        <property type="term" value="F:NADP+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042351">
        <property type="term" value="P:'de novo' GDP-L-fucose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05260">
        <property type="entry name" value="GDP_MD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:001053">
        <property type="entry name" value="GDP-mannose 4,6 dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00955">
        <property type="entry name" value="GDP_Man_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006368">
        <property type="entry name" value="GDP_Man_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01472">
        <property type="entry name" value="gmd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43715:SF1">
        <property type="entry name" value="GDP-MANNOSE 4,6 DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43715">
        <property type="entry name" value="GDP-MANNOSE 4,6-DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="11">
        <location>
            <begin position="8"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00050823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00059383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00071431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005019218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="359" mass="40872" checksum="FBD84C19B7E82072" modified="2022-01-19" version="1">MGDKKVALITGITGQDGSYLAEFLLEKGYEVHGIVRRSSSFNTGRIEHLYKNSQAHIEGNMKLHYGDLTDSTCLVKIINEVKPNEIYNLGAQSHVKISFDLAEYTADVDGVGTLRLLDAIKTCGLINSVKFYQASTSELFGKVQEIPQKETTPFYPRSPYGAAKLYAYWIVVNFREAYNLFAVNGILFNHESPRRGANFVTRKISRSVAKIHLGQMDSFSLGNLDAKRDWGHARDYVEAMWLMLQTDEPEDFVIATGEVHSVREFVEKSFKHIGKTIVWEGKNENEVGRCKETGKIHVTVNHKYYRPTEVDFLQGDCTKARQKLNWKPRVTFDVSRGFCAYQEFMSHRSHLGWGAWHGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TZQ5</accession>
    <name>A0A8C2TZQ5_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">F-box/LRR-repeat protein 16</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">F-box and leucine-rich repeat protein 16</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">FBXL16</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with SKP1 and CUL1.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015732698.1">
        <property type="nucleotide sequence ID" value="XM_015877212.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TZQ5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005029111.1">
        <property type="protein sequence ID" value="ENSCJPP00005021177.1"/>
        <property type="gene ID" value="ENSCJPG00005016949.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107320895"/>
    <dbReference type="KEGG" id="cjo:107320895"/>
    <dbReference type="CTD" id="146330"/>
    <dbReference type="GeneTree" id="ENSGT00940000159138"/>
    <dbReference type="OrthoDB" id="10044893at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22127">
        <property type="entry name" value="F-box_FBXL16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000262">
        <property type="entry name" value="F-box/LRR-repeat protein 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000733">
        <property type="entry name" value="F-box/LRR-repeat protein 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050648">
        <property type="entry name" value="F-box_LRR-repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13382:SF66">
        <property type="entry name" value="F-BOX AND LEUCINE RICH REPEAT PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13382">
        <property type="entry name" value="MITOCHONDRIAL ATP SYNTHASE COUPLING FACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box/LRR-repeat protein 15-like leucin rich repeat" evidence="10">
        <location>
            <begin position="348"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="90"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00062674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00074003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00080414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005021177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="503" mass="54705" checksum="8EA5769B05A9D6CC" modified="2022-01-19" version="1">MSNSRNGDTKPPCLPRNGLVKIPTQPNGLGSASITKGTPAVKNRLCQPSSVPAILSPALTPRSDLSVPSLASPLSLAALAGVSSPPGTSLVALNSSEATPGSEHPSPERLPGSPSERQLVVDEKILNRLFWYFSACEKCVLAQVCKAWRRVLYQPKFWVGLTPVLHTKELYNVLPGGEKEFVSLQGFAVRGFDGFCLVGVSDLDICEFIDNYPLSKKGVKSMSLKRSTITDAGLEVMLEQMQGVVRLELSGCNDFTEAGLWSSLNARITALSVSDCINVADDAIAAISQLLPNLAELNLQAYHVTDTALAYFTAKQGYTTHTLRLNSCWEITNHGVVNMVHSLPNLSVLSLSGCSKVTDDGVELVAENLRKLRSLDLSWCPRITDMALEYIACDLHKLEELVLDRCVRITDTGLSYLSTMSSLRSLYLRWCCQVQDFGLKHLLGMGSLRLLSLAGCPLLTTTGLSGLVQLQELEELELTNCPGATPELFKYFSQHLPCCMVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U1C7</accession>
    <name>A0A8C2U1C7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2U1C7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005028244.1">
        <property type="protein sequence ID" value="ENSCJPP00005020467.1"/>
        <property type="gene ID" value="ENSCJPG00005016486.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000166769"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000275">
        <property type="entry name" value="SRSF protein kinase 2 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF23">
        <property type="entry name" value="LOC100144966 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005020467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="188" mass="21121" checksum="BEC67B92F9B0F397" modified="2022-01-19" version="1">SLPLFHLGGDPGNQLEDADLMSIEVKIADLGSACWTYKPFSKEIQTQPYRALEVLLGLDYGTPADIWSTGCLAFEMATGECLFNPQPGKYFSRDDDHVARIIELLGRIPPQIALSWNKSTKFFRRPGALLRISRLVPRSLHTILTARLKWRKHEVPPFTSFLLSALQYAPENRSTAAQCLQHAWLSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U1D4</accession>
    <name>A0A8C2U1D4_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">EF-hand calcium binding domain 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">EFCAB6</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U1D4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005027228.1">
        <property type="protein sequence ID" value="ENSCJPP00005019693.1"/>
        <property type="gene ID" value="ENSCJPG00005015934.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000013629"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000243">
        <property type="entry name" value="EF-hand calcium binding domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000179">
        <property type="entry name" value="EF-hand calcium-binding domain-containing protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052603">
        <property type="entry name" value="EFCB6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20875:SF2">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20875">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="184"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005019693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="246" mass="28657" checksum="2F62A40EF95AB97F" modified="2022-01-19" version="1">VDDSIEHITMSSTTPSATHPETSTKLVRKIIVISWFQTSTSSRPQTTAACSAPVPNCEEIENRIRKNIRCSWRDMLKLCEEKDVSKLGEIPVSDFLAEKFHLDLSKEEINQVTTKYDIKKNGKFAYYDFLQSCILLLKPQKSTLLQRVIIPKPQNLMSPGPQSMLFYSTMLRIQPQILHCWRPMKRTFKSYDESRTGLLNVADFRQILHEYKINLSEEELFNILEYYDKTLSSKISYNDFLRAFLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U1D7</accession>
    <name>A0A8C2U1D7_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Meis homeobox 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U1D7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005030075.1">
        <property type="protein sequence ID" value="ENSCJPP00005021957.1"/>
        <property type="gene ID" value="ENSCJPG00005017524.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155643"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005021957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="160" mass="17192" checksum="659EBAD936B41F2A" modified="2022-01-19" version="1">KQRCSQNAEFINARRRIVQPMIDQSNRAGFLLDPSVSQGAAYSPEGQPMGSFVLDGQQHMGIRPAGLQGMPGDYVSQGGPMGMSMAQPSYTPPQMTPHPTQLRHGPPIHSYLPSHPHHPAMMMHGGPPTYPGITMSAQSPTMLNSVDPSVGGQVMDIHAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U1T5</accession>
    <name>A0A8C2U1T5_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Inward rectifier potassium channel 13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Inward rectifier K(+) channel Kir7.1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Potassium channel, inwardly rectifying subfamily J member 13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">KCNJ13</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ13 has a very low single channel conductance, low sensitivity to block by external barium and cesium, and no dependence of its inward rectification properties on the internal blocking particle magnesium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 20">Membrane</location>
            <topology evidence="1 20">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="20">Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015726645.1">
        <property type="nucleotide sequence ID" value="XM_015871159.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U1T5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005028930.1">
        <property type="protein sequence ID" value="ENSCJPP00005021023.1"/>
        <property type="gene ID" value="ENSCJPG00005016847.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107317930"/>
    <dbReference type="KEGG" id="cjo:107317930"/>
    <dbReference type="CTD" id="3769"/>
    <dbReference type="GeneTree" id="ENSGT01140000282491"/>
    <dbReference type="OrthoDB" id="273257at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005242">
        <property type="term" value="F:inward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034765">
        <property type="term" value="P:regulation of monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000081">
        <property type="entry name" value="inward rectifier potassium channel 13 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1400:FF:000004">
        <property type="entry name" value="inward rectifier potassium channel 13 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1400">
        <property type="entry name" value="G protein-activated inward rectifier potassium channel 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041647">
        <property type="entry name" value="IRK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016449">
        <property type="entry name" value="K_chnl_inward-rec_Kir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013518">
        <property type="entry name" value="K_chnl_inward-rec_Kir_cyto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008062">
        <property type="entry name" value="KCNJ13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040445">
        <property type="entry name" value="Kir_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767">
        <property type="entry name" value="INWARD RECTIFIER POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767:SF3">
        <property type="entry name" value="INWARD RECTIFIER POTASSIUM CHANNEL 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01007">
        <property type="entry name" value="IRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17655">
        <property type="entry name" value="IRK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005465">
        <property type="entry name" value="GIRK_kir"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01679">
        <property type="entry name" value="KIR7CHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01320">
        <property type="entry name" value="KIRCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13 20" id="KW-0407">Ion channel</keyword>
    <keyword evidence="11 20" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9 20" id="KW-0630">Potassium</keyword>
    <keyword evidence="5 20" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 20 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 20" id="KW-0813">Transport</keyword>
    <keyword evidence="8 20" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel inwardly rectifying transmembrane" evidence="22">
        <location>
            <begin position="26"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Inward rectifier potassium channel C-terminal" evidence="23">
        <location>
            <begin position="176"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="site" description="Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesium" evidence="19">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00053687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00067901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00080033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00080232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR005465-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU003822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF17655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005021023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="366" mass="41298" checksum="A30AF35B0473969F" modified="2022-01-19" version="1">MRTDTIESNNTKSSTPLLTQRYLRMVTKDGHSTFQMDGAQGQGLAYLRDAWGILMDMRWRWMMLVFSASFVIHWLVFAVLWYVLAEMNGDLELDHDSPPDNHTICVKYITSFTAAFSFSLETQLTIGYGTMFPSGDCPSAIALLAIQMVLGLMLEAFITGAFVAKIARPKNRAFSIRFTRSAVVTHTEGKPYLMFQVANTRASPLTSVQISAILYQEQENGQLHQTSIDFHLDSVTLDECPFFTFPLTYYHSIIPSSPLAALLQREAARHFELVVFLSAVQEGTGEMCQRRTSYLPSEIMLYHRFAPVLARSAKGEYQIKMENFDKTIPELPAAADSMNPRRTAKEIRINGQHVDSFQLSETGLTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U371</accession>
    <name>A0A8C2U371_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Calsequestrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">CASQ2</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR2; this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Sarcoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the calsequestrin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015730549.1">
        <property type="nucleotide sequence ID" value="XM_015875063.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U371"/>
    <dbReference type="Ensembl" id="ENSCJPT00005029852.1">
        <property type="protein sequence ID" value="ENSCJPP00005021782.1"/>
        <property type="gene ID" value="ENSCJPG00005017386.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107319840"/>
    <dbReference type="KEGG" id="cjo:107319840"/>
    <dbReference type="CTD" id="845"/>
    <dbReference type="GeneTree" id="ENSGT00390000019377"/>
    <dbReference type="OrthoDB" id="10038131at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033018">
        <property type="term" value="C:sarcoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140314">
        <property type="term" value="F:calcium ion sequestering activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048306">
        <property type="term" value="F:calcium-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060048">
        <property type="term" value="P:cardiac muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071313">
        <property type="term" value="P:cellular response to caffeine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051258">
        <property type="term" value="P:protein polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010881">
        <property type="term" value="P:regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010649">
        <property type="term" value="P:regulation of cell communication by electrical coupling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002027">
        <property type="term" value="P:regulation of heart rate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051208">
        <property type="term" value="P:sequestering of calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd03074">
        <property type="entry name" value="PDI_b'_Calsequestrin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03066">
        <property type="entry name" value="PDI_b_Calsequestrin_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03065">
        <property type="entry name" value="PDI_b_Calsequestrin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000031">
        <property type="entry name" value="Calsequestrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000033">
        <property type="entry name" value="Calsequestrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000047">
        <property type="entry name" value="Calsequestrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001393">
        <property type="entry name" value="Calsequestrin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041860">
        <property type="entry name" value="Calsequestrin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018233">
        <property type="entry name" value="Calsequestrin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041858">
        <property type="entry name" value="Calsequestrin_middle_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041859">
        <property type="entry name" value="Calsequestrin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10033">
        <property type="entry name" value="CALSEQUESTRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10033:SF15">
        <property type="entry name" value="CALSEQUESTRIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01216">
        <property type="entry name" value="Calsequestrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00312">
        <property type="entry name" value="CALSEQUESTRN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00863">
        <property type="entry name" value="CALSEQUESTRIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00864">
        <property type="entry name" value="CALSEQUESTRIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0514">Muscle protein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0703">Sarcoplasmic reticulum</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034144877" description="Calsequestrin" evidence="11">
        <location>
            <begin position="20"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="365"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="373"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005021782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="406" mass="47043" checksum="B72C2A772BD6390A" modified="2022-01-19" version="1">MKATCWILAGFCLLFCCKAEEGLNFPTYDGKDRVIDLNEKNYKSALKKYDMLCLLFHEPVGSDRVSQKQFQMTEMVLELAAQVLEPRSIGFGMVDSKKDAKLAKKLGLVEEGSLYVFKEERLIEFDGELATDVLVEFLLDLLEDPVEVINSKLELQAFDQIDDEIKLIGYFKGEDSEHYKAFEEAAEHFQPYVKFFATFDKGVAKKLGLKMNEVDFYEPFMDDPVHIPDKPYTEEELVEFVKEHKRATLRKLRPEDMFETWEDDMEGIHIVAFAEEDDPDGFEFLEILKQVARDNTDNPDLSIVWIDPDDFPLLITYWEKTFKIDLFRPQIGIVNVTDADSVWMDIRDDDDLPTAEELEDWIEDVLSGKINTEDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U3H1</accession>
    <name>A0A8C2U3H1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">EGF domain-specific O-linked N-acetylglucosamine transferase</fullName>
            <ecNumber evidence="2">2.4.1.255</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Extracellular O-linked N-acetylglucosamine transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">EOGT</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in extracellular proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc). Specifically glycosylates the Thr residue located between the fifth and sixth conserved cysteines of folded EGF-like domains.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48904"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:12251"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:90838"/>
            <dbReference type="EC" id="2.4.1.255"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48908"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:12252"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:90840"/>
            <dbReference type="EC" id="2.4.1.255"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 61 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.255" evidence="2"/>
    <dbReference type="RefSeq" id="XP_015730906.1">
        <property type="nucleotide sequence ID" value="XM_015875420.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U3H1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005031217.1">
        <property type="protein sequence ID" value="ENSCJPP00005022762.1"/>
        <property type="gene ID" value="ENSCJPG00005018101.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107319994"/>
    <dbReference type="KEGG" id="cjo:107319994"/>
    <dbReference type="CTD" id="285203"/>
    <dbReference type="GeneTree" id="ENSGT00940000156493"/>
    <dbReference type="OrthoDB" id="529273at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097363">
        <property type="term" value="F:protein O-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049625">
        <property type="entry name" value="Glyco_transf_61_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007657">
        <property type="entry name" value="Glycosyltransferase_61"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20961:SF148">
        <property type="entry name" value="EGF DOMAIN-SPECIFIC O-LINKED N-ACETYLGLUCOSAMINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20961">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04577">
        <property type="entry name" value="Glyco_transf_61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034084611" description="EGF domain-specific O-linked N-acetylglucosamine transferase" evidence="13">
        <location>
            <begin position="17"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 61 catalytic" evidence="14">
        <location>
            <begin position="334"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005022762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="525" mass="61715" checksum="02C147BE2390CFF2" modified="2022-01-19" version="1">MFILLMFALLLQEILANSRDENLTELKNDEPMYSYRTINLPDEHIPYFLHNNRHVADICKQDARCPYKKYLKKLKSCWGYEKSCKSDHRFSYPVCDYVESGWANDIETAQQIFWKQADFGYIRERLNEMKTHCKPTATGDSSLTCSQFLQHCRATNLYVDLRTAKRNHERFKEDFFQKGEIGGHCTLDVKAFLAEGQRKSPLQSWFAELQTFTSLNFRPLDDGKCDVVIEKPTYFMKLDAGVNMYHHFCDFVNLYITQHINNSFSTDVNIVMWDTSSYGYGDLFSETWKAFTDYDIIHLKTFDSKRVCFKEAVFSLLPRMRYGLFYNTPLISGCHGTGLFRAFSQHVLHRLNITQEGPKDGKIRVTILARSTDYRKILNQNELVNALKTVSTLEVKVVDYKYKELEFSEQLRITHNSDIFIGMHGAGLTHLLFLPDWAVVFELYNCEDERCYLDLARLRGIHYITWRKRNKVFPQDQGHHPTLGEHPKFTNYSFDVEEFMYLVLLAANHVSQHSKWPFRVKHDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U465</accession>
    <name>A0A8C2U465_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nuclear transcription factor Y subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">CAAT box DNA-binding protein subunit B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Nuclear transcription factor Y subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">NFYB</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NFYB/HAP3 subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2U465"/>
    <dbReference type="Ensembl" id="ENSCJPT00005031572.1">
        <property type="protein sequence ID" value="ENSCJPP00005023044.1"/>
        <property type="gene ID" value="ENSCJPG00005018303.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154917"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016602">
        <property type="term" value="C:CCAAT-binding factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22907">
        <property type="entry name" value="HFD_NFYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000027">
        <property type="entry name" value="Nuclear transcription factor Y subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027113">
        <property type="entry name" value="Transc_fact_NFYB/HAP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003956">
        <property type="entry name" value="Transcrpt_fac_NFYB/HAP3_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11064">
        <property type="entry name" value="CCAAT-BINDING TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11064:SF9">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00615">
        <property type="entry name" value="CCAATSUBUNTA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00685">
        <property type="entry name" value="NFYB_HAP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="13">
        <location>
            <begin position="191"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="44"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005023044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="382" mass="41667" checksum="AF5C7D8F6698F4B0" modified="2022-01-19" version="1">MIYFPLNRRAKGRCRTAKAACKELPTTTTNQTAATAALHRRAQTPFPGSTPPPPRARCIRPHKGGGQGREGRAGSVEGGSALRGRAGARGGEAARREGRPAAGSGAPRWDWFLRSHFLSNQTADLRREPTRAALEMDGDSSTTDASQLGIAGDYIGGSHYVIQPHDDTEDSMNDHEDTNGSKESFREQDIYLPIANVARIMKNAIPQTGKIAKDAKECVQECVSEFISFITSEASERCHQEKRKTINGEDILFAMSTLGFDSYVEPLKLYLQKFREAMKGEKGIGGTVTTGDGLSEELTEEAFTNQLPAGLITTDGQQQNVMVYTTSYQQISGIGQSCVLFEQVPQKKAVVPTAVNLIHGTAALDFNLIHFFTHKMCKKNTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U508</accession>
    <name>A0A8C2U508_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Coiled-coil domain-containing protein 80</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">CCDC80</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="6">Binds to various extracellular matrix proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CCDC80 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015730711.1">
        <property type="nucleotide sequence ID" value="XM_015875225.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015730720.1">
        <property type="nucleotide sequence ID" value="XM_015875234.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U508"/>
    <dbReference type="Ensembl" id="ENSCJPT00005029971.1">
        <property type="protein sequence ID" value="ENSCJPP00005021872.1"/>
        <property type="gene ID" value="ENSCJPG00005017467.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107319889"/>
    <dbReference type="KEGG" id="cjo:107319889"/>
    <dbReference type="CTD" id="151887"/>
    <dbReference type="GeneTree" id="ENSGT00940000164470"/>
    <dbReference type="OrthoDB" id="9898686at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010811">
        <property type="term" value="P:positive regulation of cell-substrate adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025232">
        <property type="entry name" value="DUF4174"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46792">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46792:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13778">
        <property type="entry name" value="DUF4174"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034794898" description="Coiled-coil domain-containing protein 80" evidence="9">
        <location>
            <begin position="21"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4174" evidence="10">
        <location>
            <begin position="142"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4174" evidence="10">
        <location>
            <begin position="622"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4174" evidence="10">
        <location>
            <begin position="777"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="30"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="290"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="423"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="425"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="471"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="495"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="545"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="595"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005021872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="956" mass="109056" checksum="4DC484ADB5587CD8" modified="2022-01-19" version="1">MNWRPALSLALLWTAWLVCGSEKTGRLAERGSHGVRKVPQSHRAPSNLLRRSGASPKNLSPNLQHPVAKRDSSVPPKAPANLLKEESRSQPRSIGTRTRRVQRLTAAAKYSKSEMIKDEGISTASQSRAVRFPSGSSSPNVLASFAGKNRVWVISAPHASEGYYRLMMSLLKNDVYCELAERHIQQIVLFHEEGEEGGKVRRITNEGKILEQPLDPALIPKLMSFLKLEKGKFGMVLLKKTLQVEERYPYPVRLEAMYEVIDQNPIRKIEKMRQKGFIQTCKAAGVEGQVVEDDNNGGSTPSIPSGGHVQVSAGGRKEEPRRSNNQPTRTKTVRKPMTTTVATPLPTVRTTTLPTTTTATRATTRTVTTASRPTTTTTLLPTTQRTWITKSHTTTEYHRLPAPPEATTARVVAAEDFYSPAWKANRRDRQRGHPEKHLAATRKPSKGGRYESFTEVPTAPSVHYTKASMSRFKDNRTDRKDYNHRDLNVTPGQHKPTKTKPPKKKAQEKILSNEYEDKYDPSKPASSHLEEEIASIPPKKGKESKKHERMDKPEKKKKKDRPDKLQKSEKQSKKDKAEKKGKQDKDRSKKNKKGSRTENEDFPKPNKKPFLQPPRKSVANLLDYFEGKRRLLLITTPKADNTMYVQQRDEYLESFCKMATRKISVITIFGTMNNSSMKIDHFQLDNEKPMKVIEDEDLVDQQLISELRKEYGMTYNDFFMVLTDTDMKVKQYYEVPIAMKSVFDLIDTFQSRIKDMERQKKEGIVCKEDKKQSLESFLSRFRWRRRLVVISAPSDEDWAYSQQLAALSGQACNFGLRHITILKLLGVGEDVGGVLELYPINGSATVDREDIPANLVKDIRNYFQISPEYFSMLLVGKDGNVKSWYPSPMWSMAIVYDLIDSMQLRRQEMTIQQSLGMQCPEDEYGGYGYHSYHQGYQEGYQDDYRHHGSYHHGYPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U5A0</accession>
    <name>A0A8C2U5A0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">adenosine deaminase</fullName>
            <ecNumber evidence="4">3.5.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ADA2</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>adenosine + H2O + H(+) = inosine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:24408"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. ADGF subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.4" evidence="4"/>
    <dbReference type="RefSeq" id="XP_015720720.1">
        <property type="nucleotide sequence ID" value="XM_015865234.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U5A0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005032451.1">
        <property type="protein sequence ID" value="ENSCJPP00005023723.1"/>
        <property type="gene ID" value="ENSCJPG00005018765.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107315162"/>
    <dbReference type="KEGG" id="cjo:107315162"/>
    <dbReference type="CTD" id="51816"/>
    <dbReference type="GeneTree" id="ENSGT00950000183113"/>
    <dbReference type="OrthoDB" id="7202371at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031685">
        <property type="term" value="F:adenosine receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043394">
        <property type="term" value="F:proteoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006154">
        <property type="term" value="P:adenosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046103">
        <property type="term" value="P:inosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01321">
        <property type="entry name" value="ADGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000017">
        <property type="entry name" value="Adenosine deaminase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013659">
        <property type="entry name" value="A_deaminase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006331">
        <property type="entry name" value="ADGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01431">
        <property type="entry name" value="adm_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="ADENOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409:SF39">
        <property type="entry name" value="ADENOSINE DEAMINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08451">
        <property type="entry name" value="A_deaminase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Adenosine/AMP deaminase N-terminal" evidence="11">
        <location>
            <begin position="29"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Adenosine deaminase" evidence="10">
        <location>
            <begin position="202"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005023723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="514" mass="57902" checksum="48979D6FB4EF4BB1" modified="2022-01-19" version="1">MKPPSGQGIRLACLLGLASFCLPIPLWEDRASFMQEEKARMTGGNLVLSIQEQQVSTKLVNLKKKEVAAALNTGQFPPSMHFFRAKSLIEQSAVFSILKRMPKGAVLHLHDYAMLSVDWLVYNATYLPDCYICFTHTGTVRFHFSKPHPPHPVPAQCSQWVLLETYRKQLHNVTEFDDSLLRNLTLVTDAPELAYPSQAFIWKRFEEIFLIASGLICYAPVFKAYFYQGLLELYEDNIQYVEIRAILPAVYELDGTRHNKSWSVAAYQEVSRRFAQEHPDFLGAKVIFAAHRMLNVSQIKETIITAMELRAHFPDTLAGFDLVGNEDQGHSLWEFKDVLTIPYSLGVNLPYFFHAGETDWQGTSVDNNVLDALVLNTSRIGHGLALTKHPVAKNLSLKRDIPVEVCPISNQVLLLVSDLRSHPAANLIAEGHPVVVSPDDPSIFGAKGVSYDFYEVFMAIGGMNADLRTLKQLALNSIKYSAMLPDEKAKAREVWQKKWDQFVADLTDSSLMEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U5Y8</accession>
    <name>A0A8C2U5Y8_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">choline-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="11">2.7.7.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">PCYT1B</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>phosphocholine + CTP + H(+) = CDP-choline + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:18997"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:58779"/>
            <dbReference type="ChEBI" id="CHEBI:295975"/>
            <dbReference type="EC" id="2.7.7.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:18998"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.15" evidence="11"/>
    <dbReference type="RefSeq" id="XP_015741279.1">
        <property type="nucleotide sequence ID" value="XM_015885793.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U5Y8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005029689.1">
        <property type="protein sequence ID" value="ENSCJPP00005021639.1"/>
        <property type="gene ID" value="ENSCJPG00005017302.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107325181"/>
    <dbReference type="CTD" id="9468"/>
    <dbReference type="GeneTree" id="ENSGT00940000156040"/>
    <dbReference type="OrthoDB" id="17102at2759"/>
    <dbReference type="UniPathway" id="UPA00753">
        <property type="reaction ID" value="UER00739"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004105">
        <property type="term" value="F:choline-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031210">
        <property type="term" value="F:phosphatidylcholine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001541">
        <property type="term" value="P:ovarian follicle development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd02174">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000016">
        <property type="entry name" value="Putative choline-phosphate cytidylyltransferase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041723">
        <property type="entry name" value="CCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045049">
        <property type="entry name" value="Pcy1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739:SF20">
        <property type="entry name" value="CHOLINE-PHOSPHATE CYTIDYLYLTRANSFERASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739">
        <property type="entry name" value="CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="15">
        <location>
            <begin position="80"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="312"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="239"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="315"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="343"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00026101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005021639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="367" mass="41495" checksum="49106B395ED9EBB4" modified="2022-01-19" version="1">MPVLCGGAESEAGIPKAPSDERRRGAMEELEHTCPQPRLTLTAPAPFADETSCQCRAPHEKLTIAQARLGTPVDRPVRVYADGIFDLFHSGHARALMQAKTLFPNSYLLVGVCSDELTHNFKGFTVMNENERYDAVQHCRYVDEVVRNAPWTLTPEFLEKHKIDFVAHDDIPYSSAGSDDVYKHIKEAGMFVPTQRTEGISTSDIITRIVRDYDVYARRNLQRGYTAKELNVSFINEKKYRFQNQVDKMKEKVKNVEEKSKEFVNKVEEKSHDLIQKWEEKSREFIGNFLELFGPDGALKQMFQERSGRMLQAFSPRQSPTSSPTRGRSPSRSPSPPWVFNKASPPSSPKAASASLSSMSEGDEDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U6T1</accession>
    <name>A0A8C2U6T1_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">HEXIM P-TEFb complex subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">HEXIM1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HEXIM family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015740985.1">
        <property type="nucleotide sequence ID" value="XM_015885499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U6T1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005032886.1">
        <property type="protein sequence ID" value="ENSCJPP00005024090.1"/>
        <property type="gene ID" value="ENSCJPG00005019034.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107325029"/>
    <dbReference type="KEGG" id="cjo:107325029"/>
    <dbReference type="CTD" id="10614"/>
    <dbReference type="GeneTree" id="ENSGT00390000002808"/>
    <dbReference type="OrthoDB" id="10058500at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120259">
        <property type="term" value="C:7SK snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097322">
        <property type="term" value="F:7SK snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004861">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106140">
        <property type="term" value="F:P-TEFb complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140416">
        <property type="term" value="F:transcription regulator inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002218">
        <property type="term" value="P:activation of innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007507">
        <property type="term" value="P:heart development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034244">
        <property type="term" value="P:negative regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032897">
        <property type="term" value="P:negative regulation of viral transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901798">
        <property type="term" value="P:positive regulation of signal transduction by p53 class mediator"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024872">
        <property type="entry name" value="HEXIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13469">
        <property type="entry name" value="HEXAMETHYLENE BISACETAMIDE INDUCIBLE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13469:SF8">
        <property type="entry name" value="HEXIM P-TEFB COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15313">
        <property type="entry name" value="HEXIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02094">
        <property type="entry name" value="HEXIMFAMILY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="143"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="212"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="78"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="164"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005024090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="281" mass="31950" checksum="C4CA69B85FEE94D1" modified="2022-01-19" version="1">MADAERAPEAAPADPERGEAQPDGDGDGGRLQHRQDAAEAAGDAGDHEARPAEGGEGQPGLRPRYRAAVGRAQEWPAKKKHRRRPSKNKRRWKPYSKLSWEEKQQFDERQSLRASRLRAEMFAKGQPVAPYNTTQFLMEDHDQEEPDLKTGLYPRRNAAKSDDTSEEDFLEEAAEEDGGSDGMGGDGSEFLQRDFSETYERYHVESLQNMSKQELVKEYLELEKCLSRMEDENNRLRMESKKHGEAAEAARLLELEVDRLRAENLQLLRERDVRAAEAAPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U7C8</accession>
    <name>A0A8C2U7C8_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PPFIA binding protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">PPFIBP2</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the liprin family. Liprin-beta subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2U7C8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005032131.1">
        <property type="protein sequence ID" value="ENSCJPP00005023445.1"/>
        <property type="gene ID" value="ENSCJPG00005018604.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005032135.1">
        <property type="protein sequence ID" value="ENSCJPP00005023449.1"/>
        <property type="gene ID" value="ENSCJPG00005018604.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01050000244951"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048786">
        <property type="term" value="C:presynaptic active zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007528">
        <property type="term" value="P:neuromuscular junction development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09563">
        <property type="entry name" value="SAM_liprin-beta1_2_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09566">
        <property type="entry name" value="SAM_liprin-beta1_2_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09569">
        <property type="entry name" value="SAM_liprin-beta1_2_repeat3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000005">
        <property type="entry name" value="Liprin-beta-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000007">
        <property type="entry name" value="Liprin-beta-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000017">
        <property type="entry name" value="Liprin-beta-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058914">
        <property type="entry name" value="LIPB1/2_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037617">
        <property type="entry name" value="LIPB1/2_SAM_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037618">
        <property type="entry name" value="LIPB1/2_SAM_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037619">
        <property type="entry name" value="LIPB1/2_SAM_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029515">
        <property type="entry name" value="Liprin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12587">
        <property type="entry name" value="LAR INTERACTING PROTEIN LIP -RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12587:SF18">
        <property type="entry name" value="LIPRIN-BETA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26022">
        <property type="entry name" value="CC_Liprin_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SAM" evidence="8">
        <location>
            <begin position="580"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="8">
        <location>
            <begin position="657"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="8">
        <location>
            <begin position="740"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="365"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="181"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="442"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="498"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00060046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005023449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="936" mass="105643" checksum="C7AC44B70B79D2A8" modified="2022-01-19" version="1">MASDASHMLEAALEQMDDIIAGTKSAAEYANGAYDIVSPAPSVYLGTFQILHLLEDLKMALEMLEDPQEKEALRNQIPGATAVCIREWFEENLSQVNHHSSVNNETYQERLARLEGDKESLILQVSVLTDQVEAQGEKIRDLEICLEGHQLKLNATEEMLQQELLSRTSLETQKLDLMAEVSDLKIKLVGMEKEQSEYEEKQNKAEGLLQELRHLKIKVEELENERNQYEWKLKATKAEIAQLQEQLALKDAEIERLQCQLSRTSSHSEVAEREEVYKRRLKEKHQEVQRLKIGMESLLAANEEKDRRIEELTLLLSQYRRVKEIMIAAQGSSDRIVSGGGEEELEATLRKLNVLNSPQGELFKAEASSGELSPALLSPVTHKTTEIRVPQKKKSSSLEDLQSESLEKYVDGKPVQPVVEQESKPLVKGSKYQTLPGKLPRPTQNGDQGTYNESNSPDTNDTEDNSIPGLNRIRSVSAPVLGETENMDGTVVSDDLSPLSSGTDSGPQSPLSLENRKSPKGIKKIWGKIRRTQSGNFPADDLGLAEFRRGGLRATAGPRLSRSKETKGQKSDYNAPFAQWSTERVCNWLEDFGLGQYVIFARQWVTSGHTLLTATPQDMEKEMGIKHPLHRKKLVLAIKSINTKQDEKSAQLDHIWVTRWLDDIGLPQYKDQFHESRVDGRMLQYLTVNDLLFLKVTSQLHHLSIKCAIHVLHINSFNPHCLRRRPVEESNVSPSEVVQWSNHRVMEWLRSVDLAEYAPNLRGSGVHGGLIILEPRFNGDTLAMLLNIPPQKTLLRRHLTTNFNVLIGPETQQEKRDITESAAYTPLTTTAKVRPKKLGFSHFGNLRKKKFDESTDYVCPMDTNPGATNGTQKNYTGYKGLSPLTDRELDQMEHSEGTVKQIGAFSQGISNLTTMLSQDEMLNDSRFLTPPLEDWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U7I8</accession>
    <name>A0A8C2U7I8_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Protein phosphatase 1 regulatory subunit 9B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">PPP1R9B</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Synapse</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2U7I8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005033412.1">
        <property type="protein sequence ID" value="ENSCJPP00005024528.1"/>
        <property type="gene ID" value="ENSCJPG00005019321.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158833"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0030175">
        <property type="term" value="C:filopodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032587">
        <property type="term" value="C:ruffle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0071315">
        <property type="term" value="P:cellular response to morphine"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:dendrite development"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:filopodium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030308">
        <property type="term" value="P:negative regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000474">
        <property type="term" value="P:regulation of opioid receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0150052">
        <property type="term" value="P:regulation of postsynapse assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd06790">
        <property type="entry name" value="PDZ_neurabin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000010">
        <property type="entry name" value="Neurabin-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040645">
        <property type="entry name" value="Neurabin-1/2_PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043446">
        <property type="entry name" value="Neurabin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16154">
        <property type="entry name" value="NEURABIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16154:SF24">
        <property type="entry name" value="NEURABIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17817">
        <property type="entry name" value="PDZ_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-0221">Differentiation</keyword>
    <keyword evidence="6" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <feature type="domain" description="PDZ" evidence="13">
        <location>
            <begin position="468"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="241"/>
            <end position="402"/>
        </location>
    </feature>
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        <location>
            <begin position="659"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
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            <begin position="105"/>
            <end position="117"/>
        </location>
    </feature>
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            <end position="254"/>
        </location>
    </feature>
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            <end position="296"/>
        </location>
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            <end position="306"/>
        </location>
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            <end position="364"/>
        </location>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
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            <begin position="387"/>
            <end position="397"/>
        </location>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U826</accession>
    <name>A0A8C2U826_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL10m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">39S ribosomal protein L10, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">MRPL10</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015741360.1">
        <property type="nucleotide sequence ID" value="XM_015885874.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U826"/>
    <dbReference type="Ensembl" id="ENSCJPT00005033513.1">
        <property type="protein sequence ID" value="ENSCJPP00005024618.1"/>
        <property type="gene ID" value="ENSCJPG00005019391.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107325223"/>
    <dbReference type="KEGG" id="cjo:107325223"/>
    <dbReference type="CTD" id="124995"/>
    <dbReference type="GeneTree" id="ENSGT00390000000603"/>
    <dbReference type="OrthoDB" id="360689at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd05797">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1730:FF:000006">
        <property type="entry name" value="39S ribosomal protein L10, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047865">
        <property type="entry name" value="Ribosomal_uL10_bac_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11560">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005024618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="256" mass="28907" checksum="F89DD75743D8E241" modified="2022-01-19" version="1">MAALSSPATWRRGWLPSVQFIRCGSKAVTRHWKAMHFQRQKLMAVTEYIAPRPVVPERCVAPKGKEEEEEEEYGYARLLRRQVEEAFRDNRMIAVCQYNYLPGEDMVLMRHYLRKHNIEVKFVLNEIIRPVLSQSRYKNLLPLFVTRNILLVSPETKVKEMLRVLKGVPQINLLGACIDDTILSRQGVENFAKLPSLEASHGQTLGTLALLPSQTCSMLQHAASHLSALLDGHIHQLQGQTGSPAGTEPTQSTGTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U9F9</accession>
    <name>A0A8C2U9F9_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Xaa-Pro aminopeptidase 1</fullName>
            <ecNumber evidence="6">3.4.11.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Aminoacylproline aminopeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Cytosolic aminopeptidase P</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Soluble aminopeptidase P</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">X-Pro aminopeptidase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">X-prolyl aminopeptidase 1, soluble</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="primary">XPNPEP1</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Metalloaminopeptidase that catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro. Contributes to the degradation of bradykinin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.</text>
            <dbReference type="EC" id="3.4.11.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 22">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.9" evidence="6"/>
    <dbReference type="RefSeq" id="XP_015722614.1">
        <property type="nucleotide sequence ID" value="XM_015867128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U9F9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005034699.1">
        <property type="protein sequence ID" value="ENSCJPP00005025523.1"/>
        <property type="gene ID" value="ENSCJPG00005020024.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107316052"/>
    <dbReference type="CTD" id="7511"/>
    <dbReference type="GeneTree" id="ENSGT00940000157716"/>
    <dbReference type="OrthoDB" id="9995434at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010815">
        <property type="term" value="P:bradykinin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140633">
        <property type="term" value="P:CARD8 inflammasome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043069">
        <property type="term" value="P:negative regulation of programmed cell death"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01085">
        <property type="entry name" value="APP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.350.10:FF:000001">
        <property type="entry name" value="Putative xaa-Pro aminopeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.350.10:FF:000004">
        <property type="entry name" value="xaa-Pro aminopeptidase 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000004">
        <property type="entry name" value="xaa-Pro aminopeptidase 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033740">
        <property type="entry name" value="Pept_M24B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032416">
        <property type="entry name" value="Peptidase_M24_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050422">
        <property type="entry name" value="X-Pro_aminopeptidase_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763:SF6">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16189">
        <property type="entry name" value="Creatinase_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16188">
        <property type="entry name" value="Peptidase_M24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="10 22" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase N-terminal" evidence="24">
        <location>
            <begin position="49"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24" evidence="23">
        <location>
            <begin position="328"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24 C-terminal" evidence="25">
        <location>
            <begin position="557"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00054066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00071973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00078157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00079909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00079919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00081885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU000590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF16188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005025523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="623" mass="70046" checksum="A34CB147E829BB71" modified="2022-01-19" version="1">MSPKITTELLKQLRQVMKSPRYVQEPVQAYIVPSGDAHQSEYIAPCDCRRAFISGFDGSAGTAIVTEQHAAMWTDGRYFLQAANQMDNNWTLMKMGLKDTPTQEDWLVSVLPEGSKVGVDPSIIPADQWKRMSKVLRSAGHDLVPVKENLIDTIWTDRPQRPCKPLIVLDLNYTGVSWREKIVALRSKMAERKVVWFVVTALDEVAWLFNLRGSDVEYNPVFFAYAVIGMNTIRLFIDGDRMMDPAVREHLQLDSTLEPEFKIQVMPYGSILTELHAVGADLSSKEKVWLSDKASYALTEAIPKAYRYLTPYTPICIAKAVKNALETEGMRRAHIKDAVALCELFNWLEKEVPKGTVTEIIAADKAEEFRSQQKDFVELSFATISSTGPNGAIIHYKPVPETNRTLSVNEIYLLDSGAQYKDGTTDVTRTMHFGTPSAYEKECFTYVLKGHIAVSAAIFPNGTKGHLLDSFARSALWDCGLDYLHGTGHGVGSFLNVHEGPCGISYKTFADEPLEAGMIVSDEPGYYEDGSFGIRIENVVLVIPAETKYNFKNRGSLTFEPLTLVPIQTKMIDVSLLTQKECNWVNDYHQKCREVIGAELERQGRHEALQWLIRETEPLIRVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U9M5</accession>
    <name>A0A8C2U9M5_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Acylphosphatase</fullName>
            <ecNumber evidence="5 6">3.6.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ACYP1</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 5 6">
            <text>an acyl phosphate + H2O = a carboxylate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="3.6.1.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the acylphosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.7" evidence="5 6"/>
    <dbReference type="RefSeq" id="XP_015720586.1">
        <property type="nucleotide sequence ID" value="XM_015865100.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U9M5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005033300.1">
        <property type="protein sequence ID" value="ENSCJPP00005024433.1"/>
        <property type="gene ID" value="ENSCJPG00005019246.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107315100"/>
    <dbReference type="KEGG" id="cjo:107315100"/>
    <dbReference type="CTD" id="97"/>
    <dbReference type="GeneTree" id="ENSGT00390000011103"/>
    <dbReference type="OrthoDB" id="7961613at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003998">
        <property type="term" value="F:acylphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000011">
        <property type="entry name" value="Acylphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020456">
        <property type="entry name" value="Acylphosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001792">
        <property type="entry name" value="Acylphosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036046">
        <property type="entry name" value="Acylphosphatase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017968">
        <property type="entry name" value="Acylphosphatase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10029">
        <property type="entry name" value="ACYLPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10029:SF21">
        <property type="entry name" value="ACYLPHOSPHATASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00708">
        <property type="entry name" value="Acylphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00112">
        <property type="entry name" value="ACYLPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54975">
        <property type="entry name" value="Acylphosphatase/BLUF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00150">
        <property type="entry name" value="ACYLPHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00151">
        <property type="entry name" value="ACYLPHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51160">
        <property type="entry name" value="ACYLPHOSPHATASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0007">Acetylation</keyword>
    <keyword evidence="2 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acylphosphatase-like" evidence="8">
        <location>
            <begin position="9"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005024433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="99" mass="11203" checksum="838E0CBCBB2726EC" modified="2022-01-19" version="1">MAGSEGLVSVDYEVWGRVQGVFFRKYTQSEAKRLGLVGWVQNTRHGTVQGQAQGPAGSVRELQHWLRNVGSPQSRISRAEFTNEKHITALEHTDFHIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UA70</accession>
    <name>A0A8C2UA70_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ecotropic viral integration site 2A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">EVI2A</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015736594.1">
        <property type="nucleotide sequence ID" value="XM_015881108.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015736595.1">
        <property type="nucleotide sequence ID" value="XM_015881109.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UA70"/>
    <dbReference type="Ensembl" id="ENSCJPT00005032313.1">
        <property type="protein sequence ID" value="ENSCJPP00005023588.1"/>
        <property type="gene ID" value="ENSCJPG00005018688.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107322748"/>
    <dbReference type="KEGG" id="cjo:107322748"/>
    <dbReference type="CTD" id="2123"/>
    <dbReference type="GeneTree" id="ENSGT00390000003004"/>
    <dbReference type="OrthoDB" id="9448427at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008608">
        <property type="entry name" value="Ectropic_vir_integratn_site_2A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15568">
        <property type="entry name" value="ECOTROPIC VIRAL INTEGRATION SITE 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15568:SF0">
        <property type="entry name" value="PROTEIN EVI2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05399">
        <property type="entry name" value="EVI2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019625">
        <property type="entry name" value="EVI_S2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034252162" evidence="3">
        <location>
            <begin position="28"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005023588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="254" mass="28060" checksum="B264F11DA729219A" modified="2022-01-19" version="1">MKTKRHGKPHSAFPLGIIFSLCLQISANHTDYPRVSNEIWYPICQNLTCSQNITEDNTTSLPGTDFNGKPTPTAEMQTATPQSLSSTMDPNSSTSSSAQSVPSTGGPRNTSKPKMTMTKETCEDNKFLILICFIIIAALVLICTFLFLSTIVMANKLSYLKKAQQEKRRPRSNGDILATNSFWPSAAGTWQRIPKETTGTDLVMQDLLSARDAAVQTKTQDESTESYTKDTDNKHENKGTMSHKSNSTHFVVEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UA73</accession>
    <name>A0A8C2UA73_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CDK2-associated and cullin domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">CACUL1</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Cell cycle associated protein capable of promoting cell proliferation through the activation of CDK2 at the G1/S phase transition.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts with CDK2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2UA73"/>
    <dbReference type="Ensembl" id="ENSCJPT00005034897.1">
        <property type="protein sequence ID" value="ENSCJPP00005025680.1"/>
        <property type="gene ID" value="ENSCJPG00005020128.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000000403"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000028">
        <property type="entry name" value="CDK2-associated and cullin domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042652">
        <property type="entry name" value="CACUL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46636">
        <property type="entry name" value="CDK2-ASSOCIATED AND CULLIN DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46636:SF1">
        <property type="entry name" value="CDK2-ASSOCIATED AND CULLIN DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cullin N-terminal" evidence="6">
        <location>
            <begin position="49"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00056908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00065663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00068572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005025680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="283" mass="31950" checksum="339F686906B68C2E" modified="2022-01-19" version="1">GDRPPNCDPAGAAGKGGPGGIAAAININASTSKFLMNVITIEDYKSTYWPKLDSAIDQLLTQSPGDYIPISYEQIYSCVYKCVCQQHSEQMYSDLIKKITNHLERVSKELQASPPDLYIERFNVALGQYMGALQSIVPLFIYMNKFYIETKLNRDLKDDLIKLFTEHVAEKHIYNLMPLLLEAQSTPFQITPSTMANIVKGLYTLRPEWVQMAPALFSKFIPNILPPAVESELQEYAAQDQKLQRELMQNGFTRGDQSRKRAGEELSYSKYESSALTTVLSWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UB16</accession>
    <name>A0A8C2UB16_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Claudin 18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">CLDN18</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Tight junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the claudin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2UB16"/>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UCP8</accession>
    <name>A0A8C2UCP8_COTJA</name>
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        <submittedName>
            <fullName evidence="12">Shroom family member 1</fullName>
        </submittedName>
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        <name evidence="12" type="primary">SHROOM1</name>
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        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
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        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
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                <consortium name="Ensembl"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
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        <subcellularLocation>
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            <location evidence="1">Cytoskeleton</location>
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        <text evidence="2">Belongs to the shroom family.</text>
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        <property type="entry name" value="APICAL PROTEIN/SHROOM-RELATED"/>
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        </source>
    </evidence>
    <sequence length="1354" mass="148057" checksum="F55AB50E393CB6AF" modified="2022-01-19" version="1">MAVSENETERWPCRHGGRIGAPVEPMAAPDSSCLSPVPSLGSTDHVLHLPGRADSAYSSFSGSSNVPEYHPPSCFEADCCSAPEQVPYMDSEYVRGIYNLSAASSALRCLQPCQAPSQSISGASHSPTPAECSSGSPSHRMLDQGLLPPAAPPPSPPMRLDSYRVTRHLESTKGRGRQNSGGLSECSAQSAPCMDSWPVGVSHGQTGAGSSKPAMVAARQRALEKKVPSSGSADGVSVSKLQGLRTEENGEWSPSQKPARRSNPHVYSRPSSFIFQEYLKTDSMANIPKILSAYGPADAHSVSEEVKPRPYTPAQSSVGDARGDEPCPCCKQQAALRGAELRSAMLEHGQWKGSPLCAQCLLHAELPPGQEVVEGICDLKCTDSALLIKNASRKASICTDKNECYDYKGEIGNVVREPLLNPQGKMQKSLLSCSCDGVELEQPPSGELDCGNKQCCDNTEQMAVHRSKEDSSSQPLNERCANSSSPGLNVHLEQEQPPVPYQKCQPEIQQELLRQVRDDPAGEQITRQTTPMLYYLSGGRAANTTHHSKLTQCLEGVRSSPRGFATSSHTASAWSTEMQRESSQPRKAEHRQHCANGDPLNEAEDIALGSPASSMEESSKNDYREKLKVAQKKVLRETSFKRKDLQMSLPVRLRQKPSKRPSIEHLRSFSLSSAHEDSKPAPCSASHLESLEGLKKDAEIKRPQAGRIGGRKRVTKEEKKLCYSEPEKLNQLADKEAQGNRGGDESTEQDMATARRRTPERRGRALSSSSISRTELKQIQHTALMEYMERKISQRPGSVQHIPPHKPTLQTGPSHPKWPPGGSSNPSESRKSPSNEASCQVFSKEAAPDVFPPSSPAPPPNADGGSRMVPAKPSLHPAAPDQCVSVQSIPLSGAAALGQEAECPSMQAADRCASCAVPPARPCGNHVSTPSSHDPREDGCQNHEHRDSIVGSSLCQHSEELAASTAIPSPRNRSREDAQVEKENRRGSQTGNTLMMCLELQAKASSAAAAQGNVASCLVLTAQPQPGDGGTAPGEGVKEAAACNGQGDDLQEGEMDLPQRRLWCPEDRRYEELVMDLIAKDSSLVDVLMPYPIRKTALDLMEGLFPVNFSMLEMHRRKAGVRHARENDRKSSKDVTEECPESEFTTKQRREDPTGKGNRVLSRSGDDTKDLDDITCKKLELISSLKAKVQALEEDRELVLAEAKECSMRGEELEAAVRAACKPNEFERYMMFIGDLEKVVSLLLCLSSRLARVQNAMRKVNGNTDAEEKQSLNERHKLLSRQREDAKDLKENLDRRERVVAGILAKYLTDQQLQAYRHFVQLKTSLLIEQKDLEEQIKFFEEQLENLEKSIPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UCX3</accession>
    <name>A0A8C2UCX3_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Family with sequence similarity 180 member A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FAM180A</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015721947.1">
        <property type="nucleotide sequence ID" value="XM_015866461.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UCX3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005035169.1">
        <property type="protein sequence ID" value="ENSCJPP00005025909.1"/>
        <property type="gene ID" value="ENSCJPG00005020248.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107315761"/>
    <dbReference type="KEGG" id="cjo:107315761"/>
    <dbReference type="CTD" id="389558"/>
    <dbReference type="GeneTree" id="ENSGT00940000154479"/>
    <dbReference type="OrthoDB" id="8913792at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029170">
        <property type="entry name" value="FAM180"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34034:SF2">
        <property type="entry name" value="PROTEIN FAM180A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34034">
        <property type="entry name" value="PROTEIN FAM180A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15173">
        <property type="entry name" value="FAM180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034059471" evidence="1">
        <location>
            <begin position="18"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005025909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="172" mass="20037" checksum="3DC34A3FC441CD22" modified="2022-01-19" version="1">MLWKTLLLLLFYYSAHATVNYKWSRAMLYPAAQRLKRSSAAFLNPVLQNSLEDVVLLYEFLLAELDIDKGQRISIKDEELASLRKAAEFDTICNEVIPKSITEIRRLSSRLSSYPRVLKKEDFERTVLTMVYTAYRAAQSQGHQKDTWAESFVNLYKALKHDLMFPYNKQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UEW2</accession>
    <name>A0A8C2UEW2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integrator complex subunit 14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">von Willebrand factor A domain-containing protein 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">INTS14</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the Integrator complex, composed of core subunits INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L, INTS12, INTS13, INTS14 and INTS15. The core complex associates with protein phosphatase 2A subunits PPP2CA and PPP2R1A, to form the Integrator-PP2A (INTAC) complex. INTS14 is part of the tail subcomplex, composed of INTS10, INTS13, INTS14 and INTS15.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the Integrator subunit 14 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015728760.1">
        <property type="nucleotide sequence ID" value="XM_015873274.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015728761.1">
        <property type="nucleotide sequence ID" value="XM_015873275.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UEW2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005036262.1">
        <property type="protein sequence ID" value="ENSCJPP00005026763.1"/>
        <property type="gene ID" value="ENSCJPG00005020803.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107318899"/>
    <dbReference type="KEGG" id="cjo:107318899"/>
    <dbReference type="CTD" id="81556"/>
    <dbReference type="GeneTree" id="ENSGT00390000009486"/>
    <dbReference type="OrthoDB" id="2374335at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160232">
        <property type="term" value="C:INTAC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160240">
        <property type="term" value="P:RNA polymerase II transcription initiation surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034472">
        <property type="term" value="P:snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000137">
        <property type="entry name" value="Integrator complex subunit 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039841">
        <property type="entry name" value="INTS14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045814">
        <property type="entry name" value="IntS14_b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046471">
        <property type="entry name" value="IntS14_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13532">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13532:SF3">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19435">
        <property type="entry name" value="IntS14_b-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20504">
        <property type="entry name" value="IntS14_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="10">
        <location>
            <begin position="3"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Integrator complex subunit 14 beta-barrel" evidence="11">
        <location>
            <begin position="209"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Integrator complex subunit 14 C-terminal" evidence="12">
        <location>
            <begin position="404"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="374"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00061449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00065091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF19435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005026763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="518" mass="57519" checksum="70901F97D73DCA32" modified="2022-01-19" version="1">MPTVVVMDVSLSMTRPVSVEGSEEYQRKHLAVHGLTMLFEHMATNYKLEFTALVVFSSLWELMVPFTRDYNTLQEALSNMDDYDKTCLESALLGVCNIVQQEWGAAIPCQVVLVTDGCLGIGRGSLRHSLATHNQRSESNRFPLPFPFPSKLYVMCMANLEELQSTDSLDCLERLIDLNNGEGQIFTIDGPLCLKNVQSMFGKLIDVAYTPFHAVLKCGHLTSDVQVFPRPEPFIIDEEIDPIPKAINTDLEIVGFVDIADISSPPVLSRHLVLPIALNREGDEVGPGITDDTEDENSANQIAGKIPNFCVLLHGSLKVEGMVAVVQLGPEWYGMLYSQADSKKKSNLMMSLFEPGPEPLPWLGKMAQLGPISDAKENPYGDDDNKSPFPLQPKNKRSYAQNVTVWIKPSGLQTDVQKILRNARKLPEKTQTFYKELNRLRKAALAFGFLDLLKGVADMLERECTLLPDTAHPDAAFQLTHAAQQLKVASTGASEYTAYDHNIAPLQTDFPTTSTERM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UHR6</accession>
    <name>A0A8C2UHR6_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="25">Hemicentin-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="26">Fibulin-6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="32" type="primary">HMCN1</name>
    </gene>
    <organism evidence="32 33">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="32" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="32" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="32" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="24">Involved in transforming growth factor beta-mediated rearrangement of the podocyte cytoskeleton which includes reduction of F-actin fibers and broadening, flattening and elongation of podocytes. Plays a role in basement membrane organization. May promote cleavage furrow maturation during cytokinesis in preimplantation embryos. May play a role in the architecture of adhesive and flexible epithelial cell junctions. May play a role during myocardial remodeling by imparting an effect on cardiac fibroblast migration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cleavage furrow</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Secreted</location>
            <location evidence="4">Extracellular space</location>
            <location evidence="4">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="27">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
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            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="310"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="510"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="553"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="620"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="636"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="666"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="739"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="760"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="778"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="796"/>
            <end position="821"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005000037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="821" mass="94386" checksum="14C689CEE8AC37AB" modified="2022-01-19" version="1">MWDQPWQQWPLNQQQWMQSFQHQQDPSQIDWAALAQAWIAQREASGQQSVVEQQGMMPNGQDISGIESGSNNHNNFQGDPNFNRMWQPEWGMPHQPPHPPPDQQWMAPTTGQMEIVPPSEDSNSQDSGEFASDNRHIFNQNNHNFGAPPDNFAMGPVNQFDYQHGAAFGPPQGGFHPPYWQPGPPGPPGPPAPSAPPQNRRERPSFRDRQRSPIAMPVKQEPPQIDAVKRRTLPAWIREGLEKMEREKQKKLEKERMEQQRSQMSKKDKKENDEAEEGDGPRLPQKSKFDSDEEDEDAENTEAVSVGKISRSPSPVPQEEQSEPEMTEEEKEYQMMMLTKMMLTEILLDVTNEEIYYVAKDVHRKATKAPAKQLAQSSALASLTGLGGLGGYGSGDSEDERSDRGSESSDTDDEELRHRIRQKQEAFWRKEREQQLLLEKQLEEERLQIDKVSKEMNEYMNKEQNSVSTSQEAKEIEADMVHDKKRSPNAIVPDIEPKKEGKEKERTGRSRSGTSSSGSTSSNSRSSSSSSTVSSSSYSTSSGSSRSSSRSSSPKRKKRHSRSRTPSHKVRRSRSRSYSHRNRRERSRSREKIRERRRSSRNQSAERGERRRIQSPSQERSWDRRRSSSSRDRRVGRASRSRSRDRRKPEDQHRSPPGSRHKHKSDGKDQERKKEHGGTVEKDRKKNRERERDQEKRKDKPKKEEKESKAGNHDDSRLKRKRDSERTFPRSETISVKIIRQDSRPDSKKIITKDSRKQSGSESSARSSSESPGSSKEKKAKKSKHIRSCSMEKSQRSGKKASRKHKSKSRSRSTTPPRRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y510</accession>
    <name>A0A8C2Y510_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cathepsin O</fullName>
            <ecNumber evidence="13">3.4.22.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">CTSO</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Proteolytic enzyme possibly involved in normal cellular protein degradation and turnover.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>The recombinant human enzyme hydrolyzes synthetic endopeptidase substrates including Z-Phe-Arg-NHMec and Z-Arg-Arg-NHMec.</text>
            <dbReference type="EC" id="3.4.22.42"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.42" evidence="13"/>
    <dbReference type="RefSeq" id="XP_015716455.1">
        <property type="nucleotide sequence ID" value="XM_015860969.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y510"/>
    <dbReference type="Ensembl" id="ENSCJPT00005000806.1">
        <property type="protein sequence ID" value="ENSCJPP00005000433.1"/>
        <property type="gene ID" value="ENSCJPG00005000520.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107313050"/>
    <dbReference type="KEGG" id="cjo:107313050"/>
    <dbReference type="CTD" id="1519"/>
    <dbReference type="GeneTree" id="ENSGT00940000159253"/>
    <dbReference type="OrthoDB" id="498368at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000079">
        <property type="entry name" value="Cathepsin O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0458">Lysosome</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034975009" description="Cathepsin O" evidence="15">
        <location>
            <begin position="19"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="16">
        <location>
            <begin position="106"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00053492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00066464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00072046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005000433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="319" mass="34730" checksum="CFA93059F1BE82DE" modified="2022-01-19" version="1">MGVLALGLACCLLRAAKAAFPVPPGTAGSPPWDGGGGGEEEAAALRESAKRISLLNSPSNDNGTAFYGKNQFSHLFPEEFKAIYLRSIPHKLPRYIKVPKGKEKPLPKKFDWRDKKVIAEVRNQQTCGGCWAFSVVGGIESAYAIKGNNLEELSVQQVIDCSYSNYGCSGGSTVTALSWLNQTKVKLVRDSEYTFKAQTGLCHYFAHSDFGVSIRGFAAYDFSGQEEEMMRVLVDWGPLAVTVDAVSWQDYLGGIIQYHCSSGKANHAVLITGFDRTGTIPYWIVQNSWGRTWGIDGYARVKIGSNVCGIADTVSSVFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y567</accession>
    <name>A0A8C2Y567_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription elongation regulator 1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TCERG1L</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015723105.1">
        <property type="nucleotide sequence ID" value="XM_015867619.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y567"/>
    <dbReference type="Ensembl" id="ENSCJPT00005002253.1">
        <property type="protein sequence ID" value="ENSCJPP00005001332.1"/>
        <property type="gene ID" value="ENSCJPG00005001381.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107316305"/>
    <dbReference type="KEGG" id="cjo:107316305"/>
    <dbReference type="CTD" id="256536"/>
    <dbReference type="GeneTree" id="ENSGT00940000160593"/>
    <dbReference type="OrthoDB" id="63972at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070063">
        <property type="term" value="F:RNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.440:FF:000001">
        <property type="entry name" value="Transcription elongation regulator 1 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.440:FF:000004">
        <property type="entry name" value="Transcription elongation regulator 1 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000049">
        <property type="entry name" value="Transcription elongation regulator 1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.440">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002713">
        <property type="entry name" value="FF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036517">
        <property type="entry name" value="FF_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045148">
        <property type="entry name" value="TCRG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057565">
        <property type="entry name" value="WW_TCRG1_3rd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15377">
        <property type="entry name" value="TRANSCRIPTION ELONGATION REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15377:SF5">
        <property type="entry name" value="TRANSCRIPTION ELONGATION REGULATOR 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01846">
        <property type="entry name" value="FF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23517">
        <property type="entry name" value="WW_TCERG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00441">
        <property type="entry name" value="FF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81698">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51676">
        <property type="entry name" value="FF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="WW" evidence="5">
        <location>
            <begin position="334"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="6">
        <location>
            <begin position="441"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="6">
        <location>
            <begin position="506"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="274"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="414"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="493"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="424"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00073866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005001332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="577" mass="64433" checksum="CA4E2E58F336AE91" modified="2022-01-19" version="1">MLPVPAAKRQPPLLWPAEPPWPWAVPGLLRVGAAPPPLLLSAPAVGWPVPCEPLLPLLAEHPPPLHGQWIFGAHSPVVGFSPSSGVEFVPVFPPVYTSAVPPHAGKSWIDKRLPSCKIYLNNAFALDSVWVHPEESCLFQGNEKPLLMTNQVALAIARPAPASRPLPTVVLAPPLMPGGCRRGPSPVGSPPSLALLAVEAEAPPGPPPSRVPQCRLLTLSPLRIPVLGSPFPGSASRMDARLSPLMPTQVTRVTAVAAPAVTIMTTNLVEQALKDKGRERSRASCPPALILHTDRRSNSVERDGDKDHSFKLVNEDDSTSNGNKPVASTPVPGSPWCVVWTGDDRVFFFNPTMQLSVWEKPVDLRHRGDINRILEDPPHKRKLDAAATDKNVGSCPGDENDDISVKIKRNKTEDCQVADQGKAGTEERNEKPSAAEVTPPLEERITHFRDMLLERGVSAFSTWEKELHKIVFDPRYLLLNSEERKQIFEQFVKTRIREEYKEKKNKLLLAKEEFKKLLEESKLSPRTTFKEFAEKYGRDQRFRLVQKKKDQEHFFNQFILILKKRDKENRIRLRKMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y5B3</accession>
    <name>A0A8C2Y5B3_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Myogenic factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">MYF5</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2 11">Efficient DNA binding requires dimerization with another bHLH protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015712849.1">
        <property type="nucleotide sequence ID" value="XM_015857363.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y5B3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005001776.1">
        <property type="protein sequence ID" value="ENSCJPP00005001021.1"/>
        <property type="gene ID" value="ENSCJPG00005001107.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107311104"/>
    <dbReference type="KEGG" id="cjo:107311104"/>
    <dbReference type="CTD" id="4617"/>
    <dbReference type="GeneTree" id="ENSGT00950000182959"/>
    <dbReference type="OrthoDB" id="10049614at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043425">
        <property type="term" value="F:bHLH transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043010">
        <property type="term" value="P:camera-type eye development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001502">
        <property type="term" value="P:cartilage condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048704">
        <property type="term" value="P:embryonic skeletal system morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042693">
        <property type="term" value="P:muscle cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060415">
        <property type="term" value="P:muscle tissue morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001503">
        <property type="term" value="P:ossification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045663">
        <property type="term" value="P:positive regulation of myoblast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048743">
        <property type="term" value="P:positive regulation of skeletal muscle fiber development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001952">
        <property type="term" value="P:regulation of cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035914">
        <property type="term" value="P:skeletal muscle cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001756">
        <property type="term" value="P:somitogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd18937">
        <property type="entry name" value="bHLH_TS_Myf5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000005">
        <property type="entry name" value="Myogenic factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022032">
        <property type="entry name" value="Myf5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002546">
        <property type="entry name" value="MyoD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039704">
        <property type="entry name" value="Myogenic_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11534">
        <property type="entry name" value="MYOGENIC FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11534:SF3">
        <property type="entry name" value="MYOGENIC FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01586">
        <property type="entry name" value="Basic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12232">
        <property type="entry name" value="Myf5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00520">
        <property type="entry name" value="BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-0221">Differentiation</keyword>
    <keyword evidence="7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0517">Myogenesis</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="13">
        <location>
            <begin position="85"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="220"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005001021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="258" mass="28301" checksum="2B76BCF9952CB6F0" modified="2022-01-19" version="1">MEVMDSCQFSPSELFYDSSCLSSPEGEFPEDFEPRELPPFGAPAPTEPACPEEEEHIRAPSGHHQAGHCLMWACKACKRKSTTMDRRKAATMRERRRLKKVNQAFETLKRCTTANPNQRLPKVEILRNAIRYIESLQELLREQVENYYHLPGQSCSEPTSPSSSCSDAMADCGSPVWPARGSSFEAGYCPEMPHGYATEQSGALSSLDCLSSIVDRLSPAEEPGLPLRHAGSLSPGASIDSGPGTPGSPPPRRTYQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y6J0</accession>
    <name>A0A8C2Y6J0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cilia- and flagella-associated protein 300</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">CFAP300</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. May play a role in outer and inner dynein arm assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CFAP300 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015707748.1">
        <property type="nucleotide sequence ID" value="XM_015852262.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y6J0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005006362.1">
        <property type="protein sequence ID" value="ENSCJPP00005003626.1"/>
        <property type="gene ID" value="ENSCJPG00005003768.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107308392"/>
    <dbReference type="KEGG" id="cjo:107308392"/>
    <dbReference type="CTD" id="85016"/>
    <dbReference type="GeneTree" id="ENSGT00510000047559"/>
    <dbReference type="OrthoDB" id="10259249at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y6R0</accession>
    <name>A0A8C2Y6R0_COTJA</name>
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        <submittedName>
            <fullName evidence="20">Calcium voltage-gated channel subunit alpha1 H</fullName>
        </submittedName>
    </protein>
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        <name evidence="20" type="primary">CACNA1H</name>
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        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
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        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <reaction evidence="15">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
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            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
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        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="ENSCJPP00005004576.1"/>
        <property type="gene ID" value="ENSCJPG00005004252.1"/>
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        <property type="component" value="Chromosome 14"/>
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        <property type="term" value="C:voltage-gated calcium channel complex"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008331">
        <property type="term" value="F:high voltage-gated calcium channel activity"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:aldosterone biosynthetic process"/>
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        <property type="term" value="P:calcium ion import across plasma membrane"/>
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        <property type="term" value="P:cellular response to potassium ion"/>
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        <property type="term" value="P:cortisol biosynthetic process"/>
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        <property type="entry name" value="VDCC_alpha-1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005445">
        <property type="entry name" value="VDCC_T_a1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628:SF37">
        <property type="entry name" value="VOLTAGE-DEPENDENT T-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1H"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="4"/>
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    <dbReference type="PRINTS" id="PR01629">
        <property type="entry name" value="TVDCCALPHA1"/>
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    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0851">Voltage-gated channel</keyword>
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        </source>
    </evidence>
    <sequence length="2319" mass="260956" checksum="01BB4B9AF4E1BB38" modified="2022-01-19" version="1">MSDGESREPRPAGGEVRVPITVPPRRSAEQPLDDAGSVPSGSPSRDPPPDLASEEEEQVPYPALAPTAFFCLKQTTRPRSWCLRLVCNPYPFPEGHRTPMLVILLNCVTLGMFQPCEDVECQSERCTILEAFDDFIFAFFAVEMVIKMVALGIFGKKCYLGDTWNRLDFFIVMAGMMEYSLDGHNVSLSAIRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLDRNLLPLSLLKFTEENPFICSSHRENGMQKCSNIPTRKEYKVECTLSMDSYTPNLYNPDFSSKNACINWNQYYNVCMAGDVNPHNGAINFDNIGYAWIAIFQVITLEGWVDIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRENQLMQEQRARYLSNDSTIASFSEPGSCYEELLKYICHIFRKVKRRTVRLYNNWQSKRRKKVNPNNTTNGQSRRGKKRITSIHHLIHHHHHHHHHYHLGNGNLRAPHASPEICDLELKVMKPGSQLMLPSPSPNLQSPAPPPDSESVHSIYHADCHVEGPQVNCKSSNAPANIKLAAGLSNRGNMNYPTILPSPTSKASSVPLTVCSSIAGLRRTPSRLSGLSMACPLPSPPGGTLSCELQDCPFCASLLEDPEFAFSESDSCDSDSNGVYEFTQDLRHGDHRDQLQQQRSRRKRKKKKPKERNKVTRLWKAFGSKLKRIVDSKYFNRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKVLVYGPFGYIKNPYNIFDGIIVVISVWEIIGQSDGGLSVLRTFRLLRVLKLVRFMPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFSLKTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILVEGFQAEVGGLSRGREKVQAMCKQDCIPFCDSVILSLWLNIHCVFSLPFFPEMKMYSLAVTPNGHLEGRGSMPPPIIMRTAATPMPTPKCSPHMDSVHTFVDSRRGSNASLDPLTYDQKSSSSLRSSPCANWGTNSNWGSRRSSWNSLGRAPSLKKKNQSGERESLLSGEGKGSTDDDSDDAKSSTVSRPSLHRRAESLDYRSSLDLPELLQLPPMRHSLSISPMAVLPAEYQDCNGKMVHVPSEFFLHIDGHKEEAVDYEDDMEDVILEPYKPEWCKSHEDWSLYLFSPQNRFRVMCQKVIAHKMFDHVVLVFIFLNCITIALERPDIDPHSTERIFLSVSNYIFTAIFVAEMMVKVVALGFFSGENTYLQSSWNVLDGVLVFVSIIDIIVSMASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCDGPDVKNITTKTDCTNAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGIDQQPIQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLEKKRRSKEMYLSEAQRRPYYADYSPARKYIHTLCTSHYLDLFITFIIGVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVFEAVLKLVAFGFRRFFKDRWNQLDLAIVLLSIVGITLEEIEMNAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLDCSEENPCEGLSRHATFTNFGMAFLTLFRVSTGDNWNGIMKDTLRECTREDKHCLSYLPVISPVYFVTFVLIAQFVLVNVVVAVLMKHLEESNKEAKEDAEMDAEIELEMSRGASTSATSGSRGGAVALETPGSDLMKSWCSGPDTCERDGVNSFHKVTEILLRFFLVPFWDFQRSLKHIEALAVPKHGQLGPWVPSYPHQEAEALGLMSQISHKPTQMLTDPSLSLALQGGTGSLQPQDSQNLLTVRKISVSRMHSLPNDSYMFRPVMPAKAPYPLHEVEMETYPCKSQRGSITSIRSQPVGTCSLKVPPESLHVAMRSPGREGWHRWKVLPPHVVPRSPALSKLLCRQVRGQEPAEVNPCSHLAVRHINSSAKDWGEHSEAGSCSTSPFVSPATSPVPLKNCSTSSLVAGSGKERDLKKFYSIDTKGFLTKPSWADDQRRHSIEICPSVRDGDCGFEERTEEKPRSPAHIQPESEYIHGARRKKKMSPPCISIDPPMEDDGGAASRTKPSENSMLRRRTPSSVGGGPCEQAGICSPPGCEVAMVAITPSILRVVISSSEAGKGPSDPQPNPIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y6R8</accession>
    <name>A0A8C2Y6R8_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PET117 cytochrome c oxidase chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">PET117</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PET117 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y6R8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005006950.1">
        <property type="protein sequence ID" value="ENSCJPP00005004070.1"/>
        <property type="gene ID" value="ENSCJPG00005004122.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00520000059926"/>
    <dbReference type="OrthoDB" id="76305at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031568">
        <property type="entry name" value="Pet117"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28163">
        <property type="entry name" value="PROTEIN PET117 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28163:SF1">
        <property type="entry name" value="PROTEIN PET117 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15786">
        <property type="entry name" value="PET117"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034879881" evidence="5">
        <location>
            <begin position="23"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005004070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="81" mass="9346" checksum="8446F970E2FBF007" modified="2022-01-19" version="1">MSRSSRAVLVVTALLSAATIAAVHVQQRRERERLHSGVLRDLERQSQKRENIRLLEEQIALTKRLTEERDKMLVEKGSQQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YA45</accession>
    <name>A0A8C2YA45_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">SPOCK2</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2YA45"/>
    <dbReference type="Ensembl" id="ENSCJPT00005016484.1">
        <property type="protein sequence ID" value="ENSCJPP00005011245.1"/>
        <property type="gene ID" value="ENSCJPG00005009686.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157107"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005518">
        <property type="term" value="F:collagen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050840">
        <property type="term" value="F:extracellular matrix binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005539">
        <property type="term" value="F:glycosaminoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990830">
        <property type="term" value="P:cellular response to leukemia inhibitory factor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010811">
        <property type="term" value="P:positive regulation of cell-substrate adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00104">
        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00191">
        <property type="entry name" value="TY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.30:FF:000003">
        <property type="entry name" value="SPARC/osteonectin, cwcv and kazal-like domains proteoglycan 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.800.10:FF:000001">
        <property type="entry name" value="Testican-3 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.10">
        <property type="entry name" value="Thyroglobulin type-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019577">
        <property type="entry name" value="SPARC/Testican_Ca-bd-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000716">
        <property type="entry name" value="Thyroglobulin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036857">
        <property type="entry name" value="Thyroglobulin_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13866">
        <property type="entry name" value="SPARC OSTEONECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13866:SF18">
        <property type="entry name" value="TESTICAN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10591">
        <property type="entry name" value="SPARC_Ca_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00086">
        <property type="entry name" value="Thyroglobulin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00211">
        <property type="entry name" value="TY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57610">
        <property type="entry name" value="Thyroglobulin type-1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00484">
        <property type="entry name" value="THYROGLOBULIN_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51162">
        <property type="entry name" value="THYROGLOBULIN_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="8 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0357">Heparan sulfate</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0654">Proteoglycan</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034521900" evidence="13">
        <location>
            <begin position="30"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="15">
        <location>
            <begin position="119"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="14">
        <location>
            <begin position="288"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="345"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="371"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="326"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005011245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="403" mass="43926" checksum="DFA83081CCB52EF0" modified="2022-01-19" version="1">MRGCGGHRALLPALLPALLPALLLPGASAATGPAPGGNFLEDEQWLSSIAQYGGRIRHWNRFRDDDYIRSWEDGQPPDEGEDSTKEPCQKVKCSRHKVCVPQGPQRAVCVSRKKLEHRIKQHGGCRPCHAARPAPVCGSDGHTYSSACKLEQQACLAGKQLTARCDGHCPCPTPGSTQGQWGYCGVGVSDLADLGERLRDWFQLLRENAKHNSSGGTPALAAGCKEAVGWMFGRLDTSGDRVLEQPELAAINLDKYEACIRAFFNSCDTSRDGRVTAAEWCLCFWREKPPCLRELERLQMQEAAKAQPGTFVPSCDEDGYYRRAQCEPGGAQCWCVDPQHGTELSGTRSHGHPDCEDAAGFSGDFGSGVGWEDEEEKEPEEAAEEAEEEEAEAGEGDDGGYIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YA73</accession>
    <name>A0A8C2YA73_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Leucine rich adaptor protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LURAP1</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015726001.1">
        <property type="nucleotide sequence ID" value="XM_015870515.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YA73"/>
    <dbReference type="Ensembl" id="ENSCJPT00005017122.1">
        <property type="protein sequence ID" value="ENSCJPP00005011748.1"/>
        <property type="gene ID" value="ENSCJPG00005010059.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107317618"/>
    <dbReference type="KEGG" id="cjo:107317618"/>
    <dbReference type="CTD" id="541468"/>
    <dbReference type="GeneTree" id="ENSGT00530000063790"/>
    <dbReference type="OrthoDB" id="8911462at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043123">
        <property type="term" value="P:positive regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001819">
        <property type="term" value="P:positive regulation of cytokine production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039499">
        <property type="entry name" value="LURA1/LRA25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037443">
        <property type="entry name" value="LURAP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33767:SF2">
        <property type="entry name" value="LEUCINE RICH ADAPTOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33767">
        <property type="entry name" value="LEUCINE RICH ADAPTOR PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14854">
        <property type="entry name" value="LURAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005011748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="278" mass="30597" checksum="C7E61717FCF3DAF9" modified="2022-01-19" version="1">MEGGGDALPADLRELLGKVGRRPPAGLLRGLRSEPAPSPPSPLPAPVRGARPPLADRLRALRLELAYLRAVDVKILQQLVAVNEGIEAVKWLLEEKSTLTSRCSSLASSQYSLAGSQTASRRGSWDSLQDPPDKLDSISIGSYLDTLADDMDEYSQNAAELPRALGRAEQDWGRLDPERGFTKQEKGRAEQEWPHTDLSLDRSCPDPQRFAKEPQVANGYSGKEPKLGPGERLEKGNVGGKARKAEANLENCKLNSELHLEYDAHWLWLQSQDDVTFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YBJ0</accession>
    <name>A0A8C2YBJ0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">MAST3</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005020350.1">
        <property type="protein sequence ID" value="ENSCJPP00005014264.1"/>
        <property type="gene ID" value="ENSCJPG00005011912.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157166"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05609">
        <property type="entry name" value="STKc_MAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:001045">
        <property type="entry name" value="Microtubule-associated serine/threonine kinase 1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000012">
        <property type="entry name" value="microtubule-associated serine/threonine-protein kinase 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1480.20:FF:000001">
        <property type="entry name" value="microtubule-associated serine/threonine-protein kinase 4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1480.20">
        <property type="entry name" value="MAST3 pre-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037711">
        <property type="entry name" value="MAST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015022">
        <property type="entry name" value="MAST_pre-PK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023142">
        <property type="entry name" value="MAST_pre-PK_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF140">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED SERINE_THREONINE-PROTEIN KINASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08926">
        <property type="entry name" value="DUF1908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140482">
        <property type="entry name" value="MAST3 pre-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="454"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="16">
        <location>
            <begin position="728"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="97"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="176"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="221"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="762"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="874"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="918"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="985"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1070"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1289"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="124"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="141"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="241"/>
            <end position="251"/>
        </location>
    </feature>
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        <location>
            <begin position="767"/>
            <end position="778"/>
        </location>
    </feature>
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        <location>
            <begin position="918"/>
            <end position="927"/>
        </location>
    </feature>
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        <location>
            <begin position="1078"/>
            <end position="1093"/>
        </location>
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        </source>
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</entry>
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        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
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                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="77" mass="8735" checksum="B2315B4036853080" modified="2022-01-19" version="1">RNVNAVRTAYSVWAVYCPGFYFYYFTAGTTHLPWQSSRTQESSVKLGVQIHFSQDLNFCSQETDEISNSVANAAIME</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YCG8</accession>
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        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
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                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
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        <scope>IDENTIFICATION</scope>
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        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
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        <location>
            <begin position="27"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005016234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="100" mass="10713" checksum="D6A5FD780EDDC23C" modified="2022-01-19" version="1">MSSTGCTSKLLLVLTSLLLVLPAVEAMDAGDTIAFLLGLAVSVIGFCACLGKLEAFIFLLDCEFSALLRSCLCVRKAIYGSFLAETQVYKGPFSSEEKMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YE84</accession>
    <name>A0A8C2YE84_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transcription factor 12</fullName>
        </submittedName>
    </protein>
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        <name evidence="9" type="primary">TCF12</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2YE84"/>
    <dbReference type="Ensembl" id="ENSCJPT00005027772.1">
        <property type="protein sequence ID" value="ENSCJPP00005020111.1"/>
        <property type="gene ID" value="ENSCJPG00005016236.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155047"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043425">
        <property type="term" value="F:bHLH transcription factor binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070888">
        <property type="term" value="F:E-box binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046332">
        <property type="term" value="F:SMAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045666">
        <property type="term" value="P:positive regulation of neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097210">
        <property type="term" value="P:response to gonadotropin-releasing hormone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd18945">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000001">
        <property type="entry name" value="Putative transcription factor 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051098">
        <property type="entry name" value="NeuroDiff_E-box_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11793">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11793:SF11">
        <property type="entry name" value="TRANSCRIPTION FACTOR 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="8">
        <location>
            <begin position="651"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="56"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="121"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="333"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="396"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="558"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="727"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="128"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="186"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="302"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="399"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="411"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="592"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="610"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="642"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="747"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005020111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="756" mass="81227" checksum="77AA1BD393535805" modified="2022-01-19" version="1">MSILLSAYLPAEIITKYLFCISFLLNVWTRLIAEFRVSKPAYTPLLLLQMFSPPVNSGKTRPTTLGSSQFGGSGMDERTGAASWGASGQPSPSYESSRENGSLHGKSSDLSTDIEKLKPQEGFADSPHYSDHLNDSRLGPHEGLSPTPFMNSNLMGKASDRGPFPLYGRDTGLPGCQTSLLRSDMGLGSPGQLSSSGKPGTAYYPFSGTNQRRRPLHDSSALDPLQTKKVRKVPPGLPSSVYAPSPSSDEFSRESPSYPSPKPPSSMFASTFFMQDGTHNSSDLWSSSNGMSQPGYGGMLGGSSSHMSQSGSYGSLHAHDRLSYPPHSVSPTDINASLPPMSSFHRGSTSSSPYVAASHTPPVNGSDNILGNRGNGAGGSQTGDALGKALASIYSPDHTSSSFPSNPSTPVGSPSPLTGASQWSRSGGQAPSSPNYENSLHSLKNRVEQQLHEHLQDAMSFLKDVCEQSRMEDRLDRLDDAIHVLRNHAVGPSTSLSGGHGDIHSLLGPSHNGPIGSLNSSYGASSLVAANRQASMVGAHREESVSLNSNHAVLPSTVSAQSTELNHKTQESYRALSGGLQSQSVAIGPTEIKSEHKEKDENIHEPPSSDDMKSDDESSQKDIKVSSRGRTSSTNEDEDLNPEQKIEREKERRMANNARERLRVRDINEAFKELGRMCQLHLKSEKPQTKLLILHQAVAVILSLEQQVRERNLNPKAACLKRREEEKVSAVSAEPPTPHPGSHPGLSETTNPMGHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YFQ0</accession>
    <name>A0A8C2YFQ0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Kv channel-interacting protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">KCNIP4</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the recoverin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2YFQ0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005031736.1">
        <property type="protein sequence ID" value="ENSCJPP00005023137.1"/>
        <property type="gene ID" value="ENSCJPG00005018389.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158985"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005267">
        <property type="term" value="F:potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015459">
        <property type="term" value="F:potassium channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901379">
        <property type="term" value="P:regulation of potassium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000043">
        <property type="entry name" value="Kv channel-interacting protein 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF30">
        <property type="entry name" value="KV CHANNEL-INTERACTING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="19" id="KW-0407">Ion channel</keyword>
    <keyword evidence="16" id="KW-0406">Ion transport</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-0630">Potassium</keyword>
    <keyword evidence="12" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="8" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="14" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="domain" description="EF-hand" evidence="21">
        <location>
            <begin position="140"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="21">
        <location>
            <begin position="176"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="21">
        <location>
            <begin position="224"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00040738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005023137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="270" mass="31274" checksum="7794307D703A2B90" modified="2022-01-19" version="1">MNLEGLEMIAVLIVIVLFVKVLEQFGLIEAGLEEIHLMHAVRLVVSFAAVFPWATAEEAHMNKKREVQHHCLKADTVEDEMEMATVRHRPEALELLEAQSKFTKKELQILYRGFKNECPSGVVNEETFKEIYSQFFPQGDSTTYAHFLFNAFDTDHNGSVSFEDFVMGLSILLRGTVQEKLNWAFNLYDINKDGYITKEEMLDIMKAIYDMMGKCTYPVLKEDTPRQHVETFFQKMDKNKDGVVTIDEFIESCQKDENIMRSMQLFENVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YGI2</accession>
    <name>A0A8C2YGI2_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YGI2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005033905.1">
        <property type="protein sequence ID" value="ENSCJPP00005024902.1"/>
        <property type="gene ID" value="ENSCJPG00005019594.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01050000245614"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005024902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="47" mass="4964" checksum="1B7113FC6671070A" modified="2022-01-19" version="1">MPVVPATREAEPAGSLEPRSSGLSGIAPVNSHCSVAWATQRISELRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YGT7</accession>
    <name>A0A8C2YGT7_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ladybird homeobox 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LBX1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015722390.1">
        <property type="nucleotide sequence ID" value="XM_015866904.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YGT7"/>
    <dbReference type="SMR" id="A0A8C2YGT7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005034609.1">
        <property type="protein sequence ID" value="ENSCJPP00005025455.1"/>
        <property type="gene ID" value="ENSCJPG00005019968.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107315950"/>
    <dbReference type="KEGG" id="cjo:107315950"/>
    <dbReference type="CTD" id="10660"/>
    <dbReference type="GeneTree" id="ENSGT00940000161756"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008283">
        <property type="term" value="P:cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905962">
        <property type="term" value="P:glutamatergic neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001947">
        <property type="term" value="P:heart looping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120007">
        <property type="term" value="P:negative regulation of glutamatergic neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048664">
        <property type="term" value="P:neuron fate determination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021519">
        <property type="term" value="P:spinal cord association neuron specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021522">
        <property type="term" value="P:spinal cord motor neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000098">
        <property type="entry name" value="Transcription factor LBX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000047">
        <property type="entry name" value="HTH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051892">
        <property type="entry name" value="LBX_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24336">
        <property type="entry name" value="TRANSCRIPTION FACTOR LBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24336:SF9">
        <property type="entry name" value="TRANSCRIPTION FACTOR LBX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00031">
        <property type="entry name" value="HTHREPRESSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="123"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="125"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="208"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="170"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="258"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005025455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="274" mass="30277" checksum="6736B85193A5383D" modified="2022-01-19" version="1">MTSKEEAKPSSGEERRRSPLDHLPPPANSNKPLTPFSIEDILNKPSVRRSYALCGTAHLLSAAEKHPAAGLPLSGRALLSQTSPLCALEELASKTFKGLEVSVLQAAEGRDGMTIFGQRQTPKKRRKSRTAFTNHQIYELEKRFLYQKYLSPADRDQIAQQLGLTNAQVITWFQNRRAKLKRDLEEMKADVESAKKLGPNPAVDIVALAELEPSAEGRGKARPGSPPPPPATREPGAPPPPRPASPPTERPRSRRDSEEEEDEEEEDVEIDVDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YH77</accession>
    <name>A0A8C2YH77_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transcription factor 15-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC107317045</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015724732.1">
        <property type="nucleotide sequence ID" value="XM_015869246.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YH77"/>
    <dbReference type="Ensembl" id="ENSCJPT00005035658.1">
        <property type="protein sequence ID" value="ENSCJPP00005026332.1"/>
        <property type="gene ID" value="ENSCJPG00005020482.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107317045"/>
    <dbReference type="KEGG" id="cjo:107317045"/>
    <dbReference type="GeneTree" id="ENSGT00940000166136"/>
    <dbReference type="OrthoDB" id="6106870at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11465">
        <property type="entry name" value="bHLH_TS_scleraxis_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000010">
        <property type="entry name" value="Scleraxis bHLH transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050283">
        <property type="entry name" value="E-box_TF_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349:SF40">
        <property type="entry name" value="BHLH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="8">
        <location>
            <begin position="42"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005026332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="135" mass="14740" checksum="F8431A4CF7D05E5B" modified="2022-01-19" version="1">MKANEGAEGAGQHRARDGGGAAGRPPAGNCGRRRRRREGGGRQRAAANARERDRTHSVNTAFTALRTLIPTEPVDRKLSKIETLRLASSYISHLANVLRLQSPAAPQPCPQRPICTFCLSEQRKRHRKPEGSLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SLI9</accession>
    <name>A0A8C2SLI9_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Oxidative stress-induced growth inhibitor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">OSGIN1</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Monooxygenase catalytic activity. Involved in regulation of cytokinesis; promotes RHOA activity, probably acting locally at the midbody in late cytokinesis. Monooxygenase activity is involved in stabilizing transient structures between daughter cells, termed intercellular bridges, before abscission. Regulates differentiation and proliferation through the regulation of cell death.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Midbody</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the OKL38 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015729337.1">
        <property type="nucleotide sequence ID" value="XM_015873851.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015729338.1">
        <property type="nucleotide sequence ID" value="XM_015873852.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032302981.1">
        <property type="nucleotide sequence ID" value="XM_032447090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SLI9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005001105.1">
        <property type="protein sequence ID" value="ENSCJPP00005000610.1"/>
        <property type="gene ID" value="ENSCJPG00005000702.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107319179"/>
    <dbReference type="KEGG" id="cjo:107319179"/>
    <dbReference type="CTD" id="29948"/>
    <dbReference type="GeneTree" id="ENSGT00390000006658"/>
    <dbReference type="OrthoDB" id="412005at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030308">
        <property type="term" value="P:negative regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000152">
        <property type="entry name" value="Oxidative stress-induced growth inhibitor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029731">
        <property type="entry name" value="OSGIN1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15192:SF15">
        <property type="entry name" value="OXIDATIVE STRESS-INDUCED GROWTH INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15192">
        <property type="entry name" value="PROTEIN CBG05349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13738">
        <property type="entry name" value="Pyr_redox_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0221">Differentiation</keyword>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0341">Growth regulation</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00053031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00061663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005000610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="498" mass="55367" checksum="5F6854244D118547" modified="2022-01-19" version="1">MLPDREMYSALGRHQNKSESKTIPVVIIGNGPSGICLSYLLTGYTPYFKRHSLHPHPILQSKLEEAADVSILDQDLEYLSEGLEGRSNSPVALLLDTLLRPDTDFGVSAESVLTWRHETERAISHLVLGKNPPGGAWHSIEGSMITLSRGEWMGLPDLQFKDWLKQKKRGLRNHRATAEDIAQYYQHYVVKKGLQKNFRCGTVVTSVRKVSAKSISNHAQKDLQKSDLLWNFSEENMEVFQVDGFVKTVKGDKEPFTVYAENVVLATGTYDSPTWLRVKGENLSYVHHQLSALEEAVKNNSIGITSDPVLIVGAGLTAADAILFAHHCSIPVIHVFRRRVSDPGLIFNQLPKMMYPEYHKVHQMMKEQSAACAGPYECYVSLPEHHVLSFGKDKKCILQDKNGCQKAFKISMALVLTGSNPNLSFLLNNGIDLAMDSDQPVNPKRNPIDVDPFTYECTQEKGLYALGPLAGDNFVRFVQGGALAAASSLLRKANKNPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SLK2</accession>
    <name>A0A8C2SLK2_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Solute carrier family 35 member A3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">SLC35A3</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SLK2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005000105.1">
        <property type="protein sequence ID" value="ENSCJPP00005000050.1"/>
        <property type="gene ID" value="ENSCJPG00005000092.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182827"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005459">
        <property type="term" value="F:UDP-galactose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990569">
        <property type="term" value="P:UDP-N-acetylglucosamine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3730.20:FF:000037">
        <property type="entry name" value="Nucleotide Sugar TransPorter family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10231">
        <property type="entry name" value="NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005799">
        <property type="entry name" value="UDP-gal_transpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="239"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005000050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="337" mass="37941" checksum="381A219D12439864" modified="2022-01-19" version="1">MSTNLKYLSLGILVFQTTSLVLTMRYSRTLKEEGPRYLSSTAVVLAELLKILSCVLLVYKDSKCNLRTLNRVLHDEILNKPMETLKLAIPSGIYTLQNNLLYVALSNLDAATYQVTYQLKILTTALFSVSMLSKKLGIYQWLSLVILMTGVAFVQWPSDSQATAAKEHSAGSQFVGLMAVLIACFSSGFAGVYFEKILKETKQSVWIRNIQLGFFGSIFGLMGVYIYDGEQLSKNGFFQGYNKLTWIVLQYFAGTWRPGDCCRYKIRRQHFKGICNFSLYYTFNIDLLFLASGFSNFCFFSSIPILFSVFFFGAILVIAATFLYGYDPKPAGNPIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SNK9</accession>
    <name>A0A8C2SNK9_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NRDE-2, necessary for RNA interference, domain containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">NRDE2</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NRDE2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015720835.1">
        <property type="nucleotide sequence ID" value="XM_015865349.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SNK9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005000545.1">
        <property type="protein sequence ID" value="ENSCJPP00005000284.1"/>
        <property type="gene ID" value="ENSCJPG00005000369.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107315227"/>
    <dbReference type="KEGG" id="cjo:107315227"/>
    <dbReference type="CTD" id="55051"/>
    <dbReference type="GeneTree" id="ENSGT00390000005524"/>
    <dbReference type="OrthoDB" id="297219at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048255">
        <property type="term" value="P:mRNA stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046833">
        <property type="term" value="P:positive regulation of RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd22200">
        <property type="entry name" value="NRDE2_MID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000185">
        <property type="entry name" value="NRDE-2, necessary for RNA interference, domain-containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013633">
        <property type="entry name" value="NRDE-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13471:SF0">
        <property type="entry name" value="NUCLEAR EXOSOME REGULATOR NRDE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13471">
        <property type="entry name" value="TETRATRICOPEPTIDE-LIKE HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08424">
        <property type="entry name" value="NRDE-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005000284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1159" mass="131885" checksum="019FF804DD579485" modified="2022-01-19" version="1">MALFPAFAGAPEPGEAPAGSSEGSRRELDWLSNPSFSTEDALLLHQRTTEAANLAPEKSPLVRSTSRSGLSGESDTDESLKKSSKKRKKKKKKHHHYKTKKKAKGDSSSSESDLDTKHIKDKAAANLDDKTSNLTSNRFVWLDDVKAFTEETFRIDKKSDPSNWAYKSLYRGDIARYKRRGESCLGIDAKKQCIAWDNPTSEKKQLQKRPERYFSKSNVKTLNIDGIPVCNRSSPSDPAAFIPVFHAETSDPSDTTEVNPLGIYDPSTTEWLQGKGYKGEEHEPVNTQQAFQEPGINVNPILMAKVEEHNKKVRENPRDVQAWMNFVSFQDELMRGPSPYASTGEQEVRRKSLKLVLEKKLAILERAIESNPSNVELKLARLNVCTEFWESPAVIKEWQKLIFIHPNNPELWKKYLLFCQSQFSTFSVSKINSLYGKCLTTLAAVQDGSMVSHPPLPGTEEAMLAIFIQQCHFLRQAGHSEKAVSLFQALIDFTFFKPDSVKDLPTKGQVEFFEPFWDSGKPRIGEKGARGWRAWMHQQEKGGWVAVDNPDDDDEEEIDEDEEIKDKTRPKWHIWMDIEYSRESRHWLPWRPDKTKNQAEEDCEDPERQVLFDDLGPSLIQLSNPDIQRQLLYSFLQFLGVPCINKLFPPSLYIAMDENNIFDNVLSDEKPLTCIDTPLSGFSSIGHMDTMQRRRHHIGHRKDGEEFIQNVFHALSPLFSGKEKSNLSVCWLQYEISKVVQCIQTKKKKKLKAQGRKSKKLAKNLLKAPDNRNNLALWKLYAYLEWLLGNTDDARKVFDTALCTAGTGGLKSPQLCSLSLLYAQLEVELLQSLEGAVTSRAVHILTKLAESRPYAPYSGQVLSVSVLKARKTYEHALQDCLNKAPVSDQDRTSHSNQLVNLVGCYTVFQYLTVGIDAAELVCAQALEKLEAPHPQKRENAAETPSIQHSPTALEAVTLLRANLLRFHMKISVYPLNPLREALTEALKWFPSNQALWRAYIQSQRKSHSASKARRFFDGVTRSTNSLEPWLFAIQAEQMRKKLIENVQRADVGEVFSTIPETGLTNRIISLFEHATQSENGTHCPLLWRMYLNFLVSVGKIERSKGLFYKAIQNCPWAKVLYMDAVEYFPEQLQETLDLMTEKELRVRVPMEELDLLLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SPB7</accession>
    <name>A0A8C2SPB7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC107310808</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Odorant receptor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cell membrane</location>
            <topology evidence="2 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SPB7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005001249.1">
        <property type="protein sequence ID" value="ENSCJPP00005000707.1"/>
        <property type="gene ID" value="ENSCJPG00005000786.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01050000244828"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15227">
        <property type="entry name" value="7tmA_OR14-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000037">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050516">
        <property type="entry name" value="Olfactory_GPCR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26452">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 12" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13" id="KW-0552">Olfaction</keyword>
    <keyword evidence="10 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="11 12" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="195"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="39"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005000707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="312" mass="34450" checksum="28429E6DE69DD687" modified="2022-01-19" version="1">MSNSSSISEFLLLPLGNTRQLQLLHFWLLLGIYLASLLGNGLISIAVACDQCLHTPMYFFLLNLALLDLGCISTTLPKAMANALWDTRAISYTGCAAQIFFLVFLSSAEYSLLTVMSYDRYVAICKPLHYGTLLDSRACANMAAAAWGTGALYSLLHTINTFSLPLCQGNVLNQFFCEIPQILKLSCSGSYHREVVLLIFSVSLAFGCYVFIVVSYVQIFMAVLRMPSEQGRHKAFSTCLPHLAVVSLFVSTACFALLKPFSISSPLLDLTVALLYSVVPPAVNPFIYSMRNWEVRDAVRKVITKCQLSQLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SPI1</accession>
    <name>A0A8C2SPI1_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Protein O-glucosyltransferase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">POGLUT3</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[EGF-like domain protein] + UDP-alpha-D-glucose = 3-O-(beta-D-glucosyl)-L-seryl-[EGF-like domain protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:58116"/>
            <dbReference type="Rhea" id="RHEA-COMP:14610"/>
            <dbReference type="Rhea" id="RHEA-COMP:16010"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:140576"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose = 3-O-(beta-D-xylosyl)-L-seryl-[EGF-like domain protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:62016"/>
            <dbReference type="Rhea" id="RHEA-COMP:16010"/>
            <dbReference type="Rhea" id="RHEA-COMP:16011"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57632"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132085"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KDELC family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015707725.1">
        <property type="nucleotide sequence ID" value="XM_015852239.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SPI1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005003225.1">
        <property type="protein sequence ID" value="ENSCJPP00005001865.1"/>
        <property type="gene ID" value="ENSCJPG00005001927.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107308374"/>
    <dbReference type="KEGG" id="cjo:107308374"/>
    <dbReference type="CTD" id="143888"/>
    <dbReference type="GeneTree" id="ENSGT00940000159028"/>
    <dbReference type="OrthoDB" id="541052at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035251">
        <property type="term" value="F:UDP-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035252">
        <property type="term" value="F:UDP-xylosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000419">
        <property type="entry name" value="KDEL (Lys-Asp-Glu-Leu) containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001298">
        <property type="entry name" value="Filamin/ABP280_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF18">
        <property type="entry name" value="PROTEIN O-GLUCOSYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00630">
        <property type="entry name" value="Filamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00557">
        <property type="entry name" value="IG_FLMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50194">
        <property type="entry name" value="FILAMIN_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034990645" evidence="12">
        <location>
            <begin position="22"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="10">
        <location>
            <begin position="20"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="13">
        <location>
            <begin position="227"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="480"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="480"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="494"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005001865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="504" mass="58294" checksum="0AD7A9DB3CB8700C" modified="2022-01-19" version="1">MGSRCCALLLLGAALPLLGSAAVSPERSVVWGPGLEAGLALPVRYFYIQAVSETGRNFSRSPPGRTQFKVVIKALSPKEITRIYTPHPLDRNDGTFLMRYRMYGSVRKGLKIEILYGDKHVAQSPYILKGPVYHEYCDCPEEDPEIWQNVFSCPSQEPQITKDFISFPTIDLQRMFKEIPSKFSQTRGAIVHYTILNNHIYRRSLGKYTDFKMFSDEMLLSLARKVHLPNVEFYLNVGDWPVEYRKANDTPGPIPIISWCGSVDSRDIVLPTYDVTHSTLETLRGVTNDLLSIQGNTGPFWDSKTEQALFRGRDSREERLYLVKLSKENPELLDAGITGYFFFREKEKELGKVPLMGFFDFFKYKYQVNVDGTVAAYRFPYLLLGDSLVLKQDSQYYEHFYTVLKPWKHYVPVKRSLEDLLEKIKWAKENDEEAQKIAKEGQSMARELLQPHRLYCYYYKVLQKYAERQASEPEIRDGMELVPQPDDRDSVCSCHRKKPLREDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SPN2</accession>
    <name>A0A8C2SPN2_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pentatricopeptide repeat domain 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">PTCD1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SPN2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005002200.1">
        <property type="protein sequence ID" value="ENSCJPP00005001301.1"/>
        <property type="gene ID" value="ENSCJPG00005001347.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153974"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042780">
        <property type="term" value="P:tRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000638">
        <property type="entry name" value="Pentatricopeptide repeat domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001927">
        <property type="entry name" value="Pentatricopeptide repeat domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000255">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24014">
        <property type="entry name" value="2-OXOGLUTARATE AND IRON-DEPENDENT OXYGENASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24014:SF6">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="PPR" evidence="1">
        <location>
            <begin position="212"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="1">
        <location>
            <begin position="286"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="1">
        <location>
            <begin position="577"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="98"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="734"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="734"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005001301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="762" mass="86006" checksum="915436BAD04BC053" modified="2022-01-19" version="1">MGPRATRAAPPARPGGCRENTSGSGRRFEHASSCRACAVALRWPRGGGAVCAPRFAMRPARLLLSLQPVPWRCCRAAAPLPSALFRYLRPSFPSLRGLRALSSSQPPPEVRGAEGEAGDDDDDDDDEGVEFGTLSAKFSHRKYYHKTTAVFRNLKLEEDGEEEGERRLWYGRRNTPYWYFLRCKALIKEDKLAEALELFEVQMLKEERVKPEEINYTVLIGGCGRAGYVKKAFRLYNDMKKRGLTPTEPTYTALFNACAESPWKDSGLQSALKLRQQLKDKNQELNMITYHALLKVCALCSDLRMCFDVLKEMVHKGHVPTAETFSFLLMSCIKDSENGFRYALQIWKQMTRLGIKADSHSYNLMLRAARDCGIGDPAVASKVLLRPTDENSSQLRLAPGRQKVKNQRKKGEEAAPTVQLDVEAMEKQLFQESSMQPEELIMEQNKDVNQAEIKPVPTGLYSPNVSHSKTGALMRRGQDEMQQEKAYLSQKLQFCILPNLLDSQITDTSVVSLGMVSTPSDRLSLMGDVEGFLKKMKKDNAEPDIKTFTLLAELVEPQSPSESSLLALLDEHKVKVDVTFFNTLIRKKSKCGDLEGAKSILPALAKRRISPNLQTFCNLAIACHQKEDGLQLLSDLKRSGVTPNKFIYSALISAAVKQLNYSYLTEILRDMRNNEVPPNEVIIRQLEFAAQYPPKFDRYKSKNPYLEKVDGFRGYYYRWLKVMAGEETPHPWEKYRTAKRSTDETKEEAVQGQVGHSAPSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SPV3</accession>
    <name>A0A8C2SPV3_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Speedy/RINGO cell cycle regulator family member A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">SPDYA</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Speedy/Ringo family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015712395.1">
        <property type="nucleotide sequence ID" value="XM_015856909.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032299464.1">
        <property type="nucleotide sequence ID" value="XM_032443573.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032299465.1">
        <property type="nucleotide sequence ID" value="XM_032443574.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032299466.1">
        <property type="nucleotide sequence ID" value="XM_032443575.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032299467.1">
        <property type="nucleotide sequence ID" value="XM_032443576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SPV3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005002431.1">
        <property type="protein sequence ID" value="ENSCJPP00005001466.1"/>
        <property type="gene ID" value="ENSCJPG00005001470.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107310871"/>
    <dbReference type="CTD" id="245711"/>
    <dbReference type="GeneTree" id="ENSGT00940000154524"/>
    <dbReference type="OrthoDB" id="9442170at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070200">
        <property type="term" value="P:establishment of protein localization to telomere"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007140">
        <property type="term" value="P:male meiotic nuclear division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070197">
        <property type="term" value="P:meiotic attachment of telomere to nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048477">
        <property type="term" value="P:oogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016233">
        <property type="term" value="P:telomere capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020984">
        <property type="entry name" value="Speedy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052316">
        <property type="entry name" value="Speedy-Ringo_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31545">
        <property type="entry name" value="SEEDY PROTEIN A/C FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31545:SF4">
        <property type="entry name" value="SPEEDY PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11357">
        <property type="entry name" value="Spy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="272"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="274"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005001466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="308" mass="35692" checksum="D220D90C635E3F2A" modified="2022-01-19" version="1">MRHSLVCHTPPAAHLKPSASRTQQQKKPVRAKRLSSRNRREMCEKRVPKGTSGHPAASCLVIQRQEMTAFFKLFDDDLIQDFLWMDCCCKIADKYLLAMTFVYFKRANFTTEEHTRLNFFVALYLANNVEEDNEESKYEIFPWALGKNWRKLFPDFLKLRDHLWSRIDYRAIVSRRCCEEVMAIAPTHYIWQRERSVYHSGAIRNYNKDEAQLPRGPNNSPIPCYLCGKKGRFVRLGLSSSSSSSTSSVEVAELCSPQDLKDTFATEKMLVDSPASSAQDCQSLSSKRRRDNTLNQDKSMDWFMSNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SQ36</accession>
    <name>A0A8C2SQ36_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nucleolar protein interacting with the FHA domain of MKI67</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">NIFK</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SQ36"/>
    <dbReference type="Ensembl" id="ENSCJPT00005001591.1">
        <property type="protein sequence ID" value="ENSCJPP00005000896.1"/>
        <property type="gene ID" value="ENSCJPG00005000944.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000011515"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12307">
        <property type="entry name" value="RRM_NIFK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021043">
        <property type="entry name" value="NIFK_FHA_Ki67-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46754">
        <property type="entry name" value="MKI67 FHA DOMAIN-INTERACTING NUCLEOLAR PHOSPHOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12196">
        <property type="entry name" value="hNIFK_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="43"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="213"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="271"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005000896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="281" mass="31972" checksum="1EB0C89C89F339AA" modified="2022-01-19" version="1">MAEAASCGAAPPSFLSLEPQLQRAVQNKVRRVRSNKAERLTPGVVYVGHLPRGLCEPQLREYFQQFGTVTRMRLSRSKKTGGSKGYAFIEFESDDVAKIVADTMNNYLFSERLLKCQFMPPERVHADLFKNSHRMFHKPSQPAVKRYNKVRSLVEKAKMAKRLLRKENNLRKRLAEKGIKYSFPGFVSLGWFQWVIVPSECFSDQPGKTKRCCHPAPQSIHPEPGGSSLQLEDPTPVCTPTVLQRRKAHQADDDTEDNEIVIKLPPPSAKKTAKREKKRQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SQC9</accession>
    <name>A0A8C2SQC9_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SWIM-type zinc finger 7 associated protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">SWSAP1</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SQC9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005002845.1">
        <property type="protein sequence ID" value="ENSCJPP00005001682.1"/>
        <property type="gene ID" value="ENSCJPG00005001730.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097196">
        <property type="term" value="C:Shu complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28653">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28653:SF1">
        <property type="entry name" value="ATPASE SWSAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005001682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="233" mass="24141" checksum="4AB23383927CD11A" modified="2022-01-19" version="1">AAIGCSRMAAILEQALGPERAEPGPTWPLLVLGPVGSGRTALLLRAALAGGGDGPRVLYMAPTRLELRYPPTLAALTQELAAMATRARPPGLLLVDGLEHYIQWRPNAAARLAAMLLEASRASHPPTPLIASLCLPPVPPHPTGHHVLPILRRYFLAECHLRPTDGTHMGVEVCLIQPGGASRGWRVRFGDQGGISVMARDGDGDGSDGGGGGDGDGGGSLGGDVMLRSLGGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SQS0</accession>
    <name>A0A8C2SQS0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DnaJ homolog subfamily C member 12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">J domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">DNAJC12</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Probable co-chaperone that participates in the proper folding of biopterin-dependent aromatic amino acid hydroxylases, which include phenylalanine-4-hydroxylase (PAH), tyrosine 3-monooxygenase (TH) and peripheral and neuronal tryptophan hydroxylases (TPH1 and TPH2).</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with HSPA8. Interacts with TPH1. Interacts with TPH2.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015721866.1">
        <property type="nucleotide sequence ID" value="XM_015866380.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015721869.1">
        <property type="nucleotide sequence ID" value="XM_015866383.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015721870.1">
        <property type="nucleotide sequence ID" value="XM_015866384.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SQS0"/>
    <dbReference type="SMR" id="A0A8C2SQS0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005001990.1">
        <property type="protein sequence ID" value="ENSCJPP00005001160.1"/>
        <property type="gene ID" value="ENSCJPG00005001223.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107315731"/>
    <dbReference type="KEGG" id="cjo:107315731"/>
    <dbReference type="CTD" id="56521"/>
    <dbReference type="GeneTree" id="ENSGT00940000159378"/>
    <dbReference type="OrthoDB" id="436519at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000049">
        <property type="entry name" value="DnaJ homolog subfamily C member 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029827">
        <property type="entry name" value="JDP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44500">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44500:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="14"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="133"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00053379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00066073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00074358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00076580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005001160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="196" mass="22891" checksum="C9DDA9B8B2C48F94" modified="2022-01-19" version="1">MDAILNCRLDELEDYYNLLGCDELSTVEQILAEFKIKALECHPDKHPGNPKAVENFQKLQQAKEVLINEESRARYDYWRRSKITIPFQQWEALSSSVKTSMHWAVQNKKDQMLEAPDLNNSNNLTNEIWTQKTENSEDGLSDGNREQDVAIPDVKPQSSKNPDSPRFSEGNYWHLRFRWSGDAPSDLLRKFRNYEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SS35</accession>
    <name>A0A8C2SS35_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein eL31</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">60S ribosomal protein L31</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">RPL31</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the large ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL31 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015705855.1">
        <property type="nucleotide sequence ID" value="XM_015850369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SS35"/>
    <dbReference type="SMR" id="A0A8C2SS35"/>
    <dbReference type="Ensembl" id="ENSCJPT00005002101.1">
        <property type="protein sequence ID" value="ENSCJPP00005001227.1"/>
        <property type="gene ID" value="ENSCJPG00005001293.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107306954"/>
    <dbReference type="KEGG" id="cjo:107306954"/>
    <dbReference type="CTD" id="6160"/>
    <dbReference type="GeneTree" id="ENSGT00950000183030"/>
    <dbReference type="OrthoDB" id="9739313at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00463">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.440.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000054">
        <property type="entry name" value="Ribosomal_eL31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020052">
        <property type="entry name" value="Ribosomal_eL31_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023621">
        <property type="entry name" value="Ribosomal_eL31_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956:SF0">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01198">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01380">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54575">
        <property type="entry name" value="Ribosomal protein L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01144">
        <property type="entry name" value="RIBOSOMAL_L31E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005001227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="125" mass="14436" checksum="4A96D36DB9EEADDC" modified="2022-01-19" version="1">MAPAKKGSEKKKGRSAINEVVTREYTINIHKRIHGVGFKKRAPRALKEIRKFAMKEMGTPDVRIDTRLNKAVWAKGIRNVPYRIRVRLSRKRNEDEDSPNKLYTLVTYVPVTTFKGLQTVNVDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2STP2</accession>
    <name>A0A8C2STP2_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Serine protease 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PRSS12</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2STP2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005006346.1">
        <property type="protein sequence ID" value="ENSCJPP00005003620.1"/>
        <property type="gene ID" value="ENSCJPG00005003756.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158131"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098685">
        <property type="term" value="C:Schaffer collateral - CA1 synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043083">
        <property type="term" value="C:synaptic cleft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043195">
        <property type="term" value="C:terminal bouton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031638">
        <property type="term" value="P:zymogen activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000053">
        <property type="entry name" value="Neurotrypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000005">
        <property type="entry name" value="Neurotrypsin isoform A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000006">
        <property type="entry name" value="neurotrypsin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19331:SF22">
        <property type="entry name" value="DELETED IN MALIGNANT BRAIN TUMORS 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19331">
        <property type="entry name" value="SCAVENGER RECEPTOR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00420">
        <property type="entry name" value="SRCR_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SRCR" evidence="10">
        <location>
            <begin position="18"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="10">
        <location>
            <begin position="125"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="10">
        <location>
            <begin position="238"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="9">
        <location>
            <begin position="369"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="43"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="56"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="263"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="276"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="307"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005003620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="613" mass="67990" checksum="95484DEE1F8E18C8" modified="2022-01-19" version="1">MTISYVPYLIIASVFTPIRLAGGNKAYEGRVEVYHAGQWGTICDDQWDDADAEVVCRQLGLGGAAKAWSQAYFGEGSGPVLLDEVRCTGNELSIEQCPKSSWREHNCDHKEDAGVSCTPLTDGALRLTSGKGSHEGRLEVYYSGQWGTICDDGWTELNTQVACRQLGFKYGKSAPESSSEGNSGPIWLDDVSCSGKETNLLQCSRREWGKHDCSHQEDVRLICHPDNNSHKLLLGPPIRLMDGENKKEGRVEIFFNGQWGTICDDGWSDKDAAVVCRQLGYKGQARARTMAYFGEGKGPIHVDNVKCTGSERSLADCIKQDIGTHNCRHSEDAGVICDHLGKKVPGNSNKDSLASVCGLRLLHRRQKRIIGGKNSLRGGWPWQVALRLKSSHGDGRLLCGATLISSCWVLTAAHCFKRYGNNTRNYAVRVGDYHTLVPEEYEEEIGVQEIVMHKEYRPDSSDYDIALVRLQGPEEQCARFSTHVLPACLPLRRERPQKTAPNCYITGWGDTGRAYSRTLQQAAIPLLPKRVCEERYKRRFTGRMLCAGNIQEQKRIDSCQGDSGGPLMCERPGESWVVYGVTSWGYGCGMKDSPGVYTKVSSFVPWIKSVTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SUV0</accession>
    <name>A0A8C2SUV0_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">ATP binding cassette subfamily C member 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">ABCC9</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSCJPT00005005392.1">
        <property type="protein sequence ID" value="ENSCJPP00005002964.1"/>
        <property type="gene ID" value="ENSCJPG00005003226.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156680"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008282">
        <property type="term" value="C:inward rectifying potassium channel"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030017">
        <property type="term" value="C:sarcomere"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005267">
        <property type="term" value="F:potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008281">
        <property type="term" value="F:sulfonylurea receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044325">
        <property type="term" value="F:transmembrane transporter binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061337">
        <property type="term" value="P:cardiac conduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0086003">
        <property type="term" value="P:cardiac muscle cell contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071318">
        <property type="term" value="P:cellular response to ATP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071277">
        <property type="term" value="P:cellular response to calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062197">
        <property type="term" value="P:cellular response to chemical stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035865">
        <property type="term" value="P:cellular response to potassium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060976">
        <property type="term" value="P:coronary vasculature development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019395">
        <property type="term" value="P:fatty acid oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048144">
        <property type="term" value="P:fibroblast proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003007">
        <property type="term" value="P:heart morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000165">
        <property type="term" value="P:MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045776">
        <property type="term" value="P:negative regulation of blood pressure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072592">
        <property type="term" value="P:oxygen metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903409">
        <property type="term" value="P:reactive oxygen species biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901379">
        <property type="term" value="P:regulation of potassium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014823">
        <property type="term" value="P:response to activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043627">
        <property type="term" value="P:response to estrogen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042542">
        <property type="term" value="P:response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904880">
        <property type="term" value="P:response to hydrogen sulfide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001666">
        <property type="term" value="P:response to hypoxia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901652">
        <property type="term" value="P:response to peptide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007519">
        <property type="term" value="P:skeletal muscle tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042311">
        <property type="term" value="P:vasodilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd18591">
        <property type="entry name" value="ABC_6TM_SUR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18602">
        <property type="entry name" value="ABC_6TM_SUR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03290">
        <property type="entry name" value="ABCC_SUR1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03288">
        <property type="entry name" value="ABCC_SUR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000005">
        <property type="entry name" value="ATP-binding cassette, sub-family C (CFTR/MRP), member 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000006">
        <property type="entry name" value="ATP-binding cassette, sub-family C (CFTR/MRP), member 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000197">
        <property type="entry name" value="ATP-binding cassette, sub-family C (CFTR/MRP), member 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000394">
        <property type="entry name" value="ATP-binding cassette, sub-family C (CFTR/MRP), member 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000388">
        <property type="entry name" value="ABCC8/9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001475">
        <property type="entry name" value="ABCC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047080">
        <property type="entry name" value="ABCC9_ATP-bd_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF173">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01094">
        <property type="entry name" value="SULFNYLUR2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01092">
        <property type="entry name" value="SULFNYLUREAR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="328"/>
            <end position="348"/>
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    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="372"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="449"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="479"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="557"/>
            <end position="585"/>
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    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="597"/>
            <end position="621"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1008"/>
            <end position="1025"/>
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    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1066"/>
            <end position="1089"/>
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    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1151"/>
            <end position="1181"/>
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        <location>
            <begin position="329"/>
            <end position="622"/>
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    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="698"/>
            <end position="938"/>
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    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="15">
        <location>
            <begin position="1068"/>
            <end position="1305"/>
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    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="1344"/>
            <end position="1578"/>
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    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="969"/>
            <end position="992"/>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="977"/>
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            <dbReference type="ARBA" id="ARBA00004651"/>
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            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005002964.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1581" mass="178419" checksum="6ABFFCFE8E2DE10F" modified="2022-01-19" version="1">MAAVVLLAVSGMLRLVADLLEAMRLAFCGNDNASAYNITAGVLRNVCFVDALNLVPHVFLLFITFPILFIGWGSQSSKVQIHHNTWLHFPGHNLRWILTFTLLFVHVCEIAEGIVSDTQMKSRHLHLFLPAIMGFVAATVSIVYYHNIETSNFPKLLLALFLYWIMAFVTKTIKLVRYCQDGVPFSQLRFCITGIMVILYGLLMAVEINVIRVRRYVFFMNPQKVKPPEDLQDLGVRFLQPFVNLLSKATYWWMNTLIISAHKKPVDLKAIGKLPIAMRALTNYVCLKEAYEEQKKKVADQPNRSPSIWLAMYSAFGRPILLSSTFRYLADLLGFAGPLCISGIVQGFQNTTHNTNTTEKDPSNSYLSSEEFLRNVYVLAVLLFLALILQRTFLQASYYVTTETGINLRGALLAMIYDKILRLSTSNLSMGEMTLGQINNLVAIETNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGVSALVGAAVIVLLAPIQYFIATKLAEAQKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELTSLKTFALHTSLSIFMNAAIPIAAVLATFVTYAYTNDKPLQPAQAFASLSLFHILVTPLFLLSTVVRFAVKAIISVQKLNEFLLSDEIGDDSWRGGDNSVAYESCKKHTGLHTKAINRRQPLRYQLENYEQSSRRQTRPVETDDIAIKVTNGYFSWGSGLATLSNINIRIPTGQMTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNETEPSFEASRSKNRYSVAYAAQKPWLLNATVEENIIFGSPFNKQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQEDKRTLVLVTHKLQYLPHADWIIAMKDGMVLREGTLKDIQNNDVELYEHWKTLMNRQDQELEKDMEADQTTLERKTLRRAMYPRESKAQLEDEDEEEEEEEDEDDNMSTVLRLRTKMPWKTCWRYLTSGGFFLLFLMIFSKLLKHSVIVAIDYWLATWTSMDNVNEFRNADDVQSAEKTYHVAVFSILSGAGIVLCLITSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDMTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMISYATPWFLVALVPLGIAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHESRFKQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTAAITSITEGPNSGFVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVHSFLNMESENYDGYLDASQVPKDWPQEGEIKIENLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGRIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGGLDAMVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVSHILESNIVLVLSDGFLVECDTASNLLLKEDGLFTTLVKTHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SV02</accession>
    <name>A0A8C2SV02_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Protein delta homolog 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">DLK1</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="12">Monomer. Interacts with SH3RF2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015721103.2">
        <property type="nucleotide sequence ID" value="XM_015865617.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SV02"/>
    <dbReference type="Ensembl" id="ENSCJPT00005004560.1">
        <property type="protein sequence ID" value="ENSCJPP00005002476.1"/>
        <property type="gene ID" value="ENSCJPG00005002737.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107315333"/>
    <dbReference type="KEGG" id="cjo:107315333"/>
    <dbReference type="CTD" id="8788"/>
    <dbReference type="GeneTree" id="ENSGT00940000154225"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045197">
        <property type="term" value="P:establishment or maintenance of epithelial cell apical/basal polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007157">
        <property type="term" value="P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045746">
        <property type="term" value="P:negative regulation of Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000018">
        <property type="entry name" value="Delta-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000321">
        <property type="entry name" value="Protein delta homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000486">
        <property type="entry name" value="Protein delta homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000551">
        <property type="entry name" value="Protein delta homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000118">
        <property type="entry name" value="protein delta homolog 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051022">
        <property type="entry name" value="Notch_Cell-Fate_Det"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049">
        <property type="entry name" value="CRUMBS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049:SF42">
        <property type="entry name" value="DELTA LIKE NON-CANONICAL NOTCH LIGAND 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21700">
        <property type="entry name" value="EGF_DL_JAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 14" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 16" id="KW-0732">Signal</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034751611" description="Protein delta homolog 1" evidence="16">
        <location>
            <begin position="25"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="17">
        <location>
            <begin position="27"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="17">
        <location>
            <begin position="93"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="17">
        <location>
            <begin position="132"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="17">
        <location>
            <begin position="175"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="17">
        <location>
            <begin position="213"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="201"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="240"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00061973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00072386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005002476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="386" mass="41307" checksum="F2C8DDEE237F3536" modified="2022-01-19" version="1">MRLRAAGLLGCCCCCCCLLPLVLPAAPGVSCKAGCHPVNGFCEFPSECRCLPGWQGAFCNQCVPFPGCLHGSCVKPWQCICEEGWVGSLCDIDIQPCSAKPCTNNSTCIETGDGGYICLCAQGFTGKNCHLRKGPCIINGSPCQNGGTCIDDSGFAPHASCLCPSGFAGNFCEIDRDDCESNPCENGGTCTDIGAGFSCLCPHGYTGKLCSSHVTFCASDPCENGGTCKEHPRGGFKCICKPEFVGATCRHASKNTSLSAVNSGTKNMQNYKLPPKAHHRSVHQEHEILKITVKETIQNADPLLSKSQVICFVVLGSLTCLVVLGTTGIVFFSKCEMWLANAKYSHLLRKKKNFLLKSSNGENLSVNIIFPEKIKLTNYTKNYTAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SV16</accession>
    <name>A0A8C2SV16_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Ras homolog family member U</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">RHOU</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015713395.1">
        <property type="nucleotide sequence ID" value="XM_015857909.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SV16"/>
    <dbReference type="Ensembl" id="ENSCJPT00005006466.1">
        <property type="protein sequence ID" value="ENSCJPP00005003687.1"/>
        <property type="gene ID" value="ENSCJPG00005003827.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107311420"/>
    <dbReference type="KEGG" id="cjo:107311420"/>
    <dbReference type="CTD" id="58480"/>
    <dbReference type="GeneTree" id="ENSGT00940000156644"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120183">
        <property type="term" value="P:positive regulation of focal adhesion disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016601">
        <property type="term" value="P:Rac protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd04130">
        <property type="entry name" value="Wrch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000561">
        <property type="entry name" value="rho-related GTP-binding protein RhoV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0564">Palmitate</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005003687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="280" mass="29994" checksum="6C39686B8247D54A" modified="2022-01-19" version="1">MPPQQEGEAGYISKPVPGGCEVPPVPPRRVRSGRAAAALGAALGGRCRAAGSGAGTSAGSGAGAGAEPRRSIKCVLVGDGAVGKTSLVVSYTTNGYPDEYQPTALDTFSAVVSVDGKPVRLQLCDTAGQDEFDKLRPLCYTNTDIFLLCFSVVSPSSFQNVSEKWVPEIRCHCPKAPIILVGTQSDLREDVKVLIELDKCKEKPVPEEAAKLCAEEIKAASYIECSALTQKNLKEVFDAAIVAGIQYSDTQQQPKKSKCRTPDKMKNLSKSWWKKYCCFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SWH3</accession>
    <name>A0A8C2SWH3_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">A disintegrin and metalloproteinase with thrombospondin motifs 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">ADMP-2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Aggrecanase-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="primary">ADAMTS5</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="17">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="21">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015737403.1">
        <property type="nucleotide sequence ID" value="XM_015881917.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SWH3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005008005.1">
        <property type="protein sequence ID" value="ENSCJPP00005004873.1"/>
        <property type="gene ID" value="ENSCJPG00005004720.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107323126"/>
    <dbReference type="KEGG" id="cjo:107323126"/>
    <dbReference type="CTD" id="11096"/>
    <dbReference type="GeneTree" id="ENSGT00940000159090"/>
    <dbReference type="OrthoDB" id="9936463at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050840">
        <property type="term" value="F:extracellular matrix binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003180">
        <property type="term" value="P:aortic valve morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003203">
        <property type="term" value="P:endocardial cushion morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022617">
        <property type="term" value="P:extracellular matrix disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007520">
        <property type="term" value="P:myoblast fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120163">
        <property type="term" value="P:negative regulation of cold-induced thermogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003184">
        <property type="term" value="P:pulmonary valve morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd04273">
        <property type="entry name" value="ZnMc_ADAMTS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000006">
        <property type="entry name" value="A disintegrin and metalloproteinase with thrombospondin motifs 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.830:FF:000001">
        <property type="entry name" value="A disintegrin and metalloproteinase with thrombospondin motifs 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000001">
        <property type="entry name" value="A disintegrin and metalloproteinase with thrombospondin motifs 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1620.60:FF:000006">
        <property type="entry name" value="A disintegrin and metalloproteinase with thrombospondin motifs 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.830">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1620.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006586">
        <property type="entry name" value="ADAM_Cys-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013273">
        <property type="entry name" value="ADAMTS/ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050439">
        <property type="entry name" value="ADAMTS_ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041645">
        <property type="entry name" value="ADAMTS_CR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045371">
        <property type="entry name" value="ADAMTS_CR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010294">
        <property type="entry name" value="ADAMTS_spacer1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013276">
        <property type="entry name" value="Pept_M12B_ADAM-TS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723:SF37">
        <property type="entry name" value="A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723">
        <property type="entry name" value="ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17771">
        <property type="entry name" value="ADAMTS_CR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19236">
        <property type="entry name" value="ADAMTS_CR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05986">
        <property type="entry name" value="ADAMTS_spacer1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01421">
        <property type="entry name" value="Reprolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19030">
        <property type="entry name" value="TSP1_ADAMTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01860">
        <property type="entry name" value="ADAMTS5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01857">
        <property type="entry name" value="ADAMTSFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00608">
        <property type="entry name" value="ACR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="17" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="11 18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="12 20" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 17 21" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="23" id="KW-0732">Signal</keyword>
    <keyword evidence="8 17 21" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034656877" description="A disintegrin and metalloproteinase with thrombospondin motifs 5" evidence="23">
        <location>
            <begin position="20"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="24">
        <location>
            <begin position="217"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="23"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="184"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="22">
        <location>
            <begin position="23"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="22">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="active site" evidence="16 21">
        <location>
            <position position="361"/>
        </location>
    </feature>
    <feature type="binding site" description="in inhibited form" evidence="19">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17 21">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17 21">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17 21">
        <location>
            <position position="370"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="421"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="424"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="424"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="20">
        <location>
            <position position="678"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="292"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="321"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="338"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="376"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="447"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="464"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="492"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
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            <begin position="529"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="533"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="544"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023145"/>
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    </evidence>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00072806"/>
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            <dbReference type="ARBA" id="ARBA00079522"/>
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        <source>
            <dbReference type="PIRSR" id="PIRSR613273-1"/>
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        <source>
            <dbReference type="PIRSR" id="PIRSR613273-2"/>
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    </evidence>
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    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
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    </evidence>
    <sequence length="881" mass="96194" checksum="C3BE03F2C1D79220" modified="2022-01-19" version="1">MLPAPLSLLLVALLPFAPAHPPPPAAAGAPPPPPPGAAPTTPPPRPGPPPGPPRGASGVVRRLDPTYAGGGRAGFVLYAGGRRFLLDLERDEAPGAPRNGGPPRCYYRGTVDGNPRSLAVFNLCGGLDGFFAVGRARYTVKPARRGGEEKDEEEEGGTRIYGEGPARAPHFFRRERFSFETLPARPSCETRGPAGAATAPESGRRKRRRRRSVSRARQVELLLVADASMARKYGKGLQHYLLTLASIASRLYAHASLENHVRLAVVKVVVLGEKEKGLEVNRNAATTLKNFCKWQHQHNRLDDDHDEHYDAAILFTREDLCGHHSCDTLGMADVGTICSPERSCAVIEDDGLHAAFTVAHEIGHLLGLSHDDSKFCEENFGSMEDKRLMSSILTSIDASKPWSKCTSATITEFFDDGHGNCLLDQPRKQILGPEELPGQTYDAIRQCKLAFGPEYTVCPGMDVCSRLWCAVVRQGQMVCLTKKLPAVEGTPCGKGRICLQGKCVDKTKKKYYSASSHGNWGSWGPWGQCSRTCGGGVQFAYRHCNNPAPRNNGRYCTGKRAIYRSCNVTPCPANAKSFRQEQCEARNGYQSDAKGVKTFVEWVPKYAGVLPGDVCKLTCRAKGTGYYVVFSQKVTDGTECRPYSNSVCVRGKCIRTGCDGIIGSKLQYDKCGVCGGDNSSCTKVMGTFTKKSKGYTDIVKIPEGATHIKVRQFKTKDQSRFTAYLALKKKNGEYLVNGKYMISTSETIIDINGTVMNYSGWSHKDDFLHAMGHSATKEVLIVQILATDPTQPVDVRYSFFVPKKQGQMTNSVSGSGSSSKVTPQLTQPRWVTGPWLSCSRTCDTGWHTRTVQCKDGHGKLAKGCLLSQRPSAFKQCLLKKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SWN3</accession>
    <name>A0A8C2SWN3_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">DENN domain containing 5A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">DENND5A</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RAB6IP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSCJPT00005007838.1">
        <property type="protein sequence ID" value="ENSCJPP00005004742.1"/>
        <property type="gene ID" value="ENSCJPG00005003964.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153678"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01757">
        <property type="entry name" value="PLAT_RAB6IP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17692">
        <property type="entry name" value="RUN2_DENND5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.900:FF:000003">
        <property type="entry name" value="DENN domain containing 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.900:FF:000008">
        <property type="entry name" value="DENN domain containing 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.60.20:FF:000001">
        <property type="entry name" value="DENN domain containing 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.900:FF:000007">
        <property type="entry name" value="DENN domain-containing protein 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.900">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.60.20">
        <property type="entry name" value="PLAT/LH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005112">
        <property type="entry name" value="dDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047278">
        <property type="entry name" value="DEN5A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001024">
        <property type="entry name" value="PLAT/LH2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036392">
        <property type="entry name" value="PLAT/LH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047277">
        <property type="entry name" value="PLAT_RAB6IP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047295">
        <property type="entry name" value="RUN2_DENND5A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004012">
        <property type="entry name" value="Run_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037213">
        <property type="entry name" value="Run_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005113">
        <property type="entry name" value="uDENN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46070:SF2">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46070">
        <property type="entry name" value="PINSTRIPE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03455">
        <property type="entry name" value="dDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01477">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02759">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03456">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00801">
        <property type="entry name" value="dDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00799">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00593">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00800">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49723">
        <property type="entry name" value="Lipase/lipooxygenase domain (PLAT/LH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140741">
        <property type="entry name" value="RUN domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50095">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50826">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="779"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="domain" description="UDENN" evidence="11">
        <location>
            <begin position="102"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="domain" description="RUN" evidence="12">
        <location>
            <begin position="871"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="domain" description="PLAT" evidence="10">
        <location>
            <begin position="1034"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="domain" description="RUN" evidence="12">
        <location>
            <begin position="1214"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="56"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005004742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1367" mass="156054" checksum="21C0C3B1C976472F" modified="2022-01-19" version="1">MRSIAVPRPAPPPSPPGHSWGPYPQCRAALPAPLHHGGGRRSWRSWRSPAARRRSAPQPLSPAQPSVSSMSGGSGGGSSAPGRFADYFVICGLDTETGLEPDELSGENFDQTPLRRTFKSKVLARYPENVEWNPFDQDAVGMLCMPKGLAFKTQADSREPQFHSFIITREDGSRTFGFSLTFYEEVTSKQICTAMQTLYQMHNAEYDILHTPPTNDKDSCSSTGDCNGTSISKLQRFNSYDISRDTLYVSKCICLITPMSFMKACKKVLEQLHQAVTSPQPPPLPLESYIYNILYEVPLPPAGRSLKFSGVYGPIICQRPSTNELPLFDFPVKEVFELLGVENVVQLFTCALLEFQILLYSQHYQRLMTVAETITALMFPFQWQHVYVPILPASLLHFLDAPVPYLMGLHSNGLDDRSKLELPQEANLCFVDVDNHFIELPEDLPQFPNKLEFVQEISEILTAFGIPPEGNLHYSESASKMKSLRACDLVSDKRNGNVAGSPLNSYELLKENETIARLQALVKRTGVSLEKVREETSSKKDLKIQCDEEEFKIYQLNIQIREIFANRFTQMFADYEVFVIQPSQDKESWFTNREQMQNFDKASFLSDQPEPYLPFLSRFLETQMFASFIDNKIMCHDEDDKDPILRVFDSRVDKIRLLNVRTPTLRTSMYQKCTTIDEAEHLNFLTISEKSIELRLAKIDHTAVHPHLLDMKIGQGKYELGFFPKLQSDVLSTGPSSVYRWTKRNAPAQWRRKDRQKQHTEHLRLDNDQREVGCKDGFTFSWCCILTCTFICFYQFSVLIQKYIQEARNLGSTIRQPKLSNLSPSVIAQTNWKFVEGLLKECRNKTKRMLVEKMGREAVELGHGEVNITGVEENTLIASLCDLLERIWSHGLQVKQVRNKYSYMLLNGFLLKEDSVLLDLGILLDSERRKSDTSPGMSPLRISLVQDMRHIQNISEIKTDVGKARAWVRLSMEKKLLSRHLKQLLSDHELTKKLYKRYAFLRCDDEKEQFLYHLLSFNAVDYFCFTNVFTTILIPYHILIVPSKKLGGSMFTANPWICISGELGETGVLQIPRNLLEMTFECQNLGKLTTVQIGHDNSGLYAKWLVEYVMVRNEITGHTYKFPCGRWLGKGMDDGSLERVLVGELLTSNTEADERQCRTPPLQQSPSMIRRLVTISPNNKPKLNTGQIQEAIGEAVNGIVKHFHKPEKERGSLTLLLCGESGLVSALEQVFQHGFKSPRLFKNVFIWDFLEKAQTYYETLEQNEMVPEENWQTRARNFCRFITAINNNPRNIGKDGKFQMLVCLGARDHLLHHWIALLADCPITAQMYEDTALIKDHTLVNSLIRVLQTLQEFNITLEASLVKGIDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SX99</accession>
    <name>A0A8C2SX99_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transmembrane protein 170A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">TMEM170A</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TMEM170 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SX99"/>
    <dbReference type="Ensembl" id="ENSCJPT00005007747.1">
        <property type="protein sequence ID" value="ENSCJPP00005004674.1"/>
        <property type="gene ID" value="ENSCJPG00005004580.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159189"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071786">
        <property type="term" value="P:endoplasmic reticulum tubular network organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006998">
        <property type="term" value="P:nuclear envelope organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051292">
        <property type="term" value="P:nuclear pore complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019334">
        <property type="entry name" value="TMEM170A/B/YPR153W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22779">
        <property type="entry name" value="SD17342P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22779:SF2">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 170A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10190">
        <property type="entry name" value="Tmemb_170"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="42"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005004674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="140" mass="14833" checksum="BBC31D6EBBDE61D8" modified="2022-01-19" version="1">MEGGDAGGGGGLLQQILSLRLVPRVGNGTTTYSSPLSTFPEMWYGVFLWALVSSLSFHVPAALLALFTLRHHKYGRFMSVSLLLMGIVGPITAGILTSAAIAGVYRAAGKKMIPFEALIFGVGQTFCVVVVSFLRILATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SY08</accession>
    <name>A0A8C2SY08_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MAGUK p55 subfamily member 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">MPP7</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell junction</location>
            <location evidence="3">Adherens junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Tight junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MAGUK family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SY08"/>
    <dbReference type="Ensembl" id="ENSCJPT00005006516.1">
        <property type="protein sequence ID" value="ENSCJPP00005003724.1"/>
        <property type="gene ID" value="ENSCJPG00005003790.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156232"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097025">
        <property type="term" value="C:MPP7-DLG1-LIN7 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070830">
        <property type="term" value="P:bicellular tight junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031334">
        <property type="term" value="P:positive regulation of protein-containing complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071896">
        <property type="term" value="P:protein localization to adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00071">
        <property type="entry name" value="GMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06799">
        <property type="entry name" value="PDZ_MPP3-MPP4-MPP7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12033">
        <property type="entry name" value="SH3_MPP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.63.10:FF:000002">
        <property type="entry name" value="Guanylate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000046">
        <property type="entry name" value="MAGUK p55 subfamily member 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.650">
        <property type="entry name" value="L27 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014775">
        <property type="entry name" value="L27_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004172">
        <property type="entry name" value="L27_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036892">
        <property type="entry name" value="L27_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050716">
        <property type="entry name" value="MAGUK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035599">
        <property type="entry name" value="MPP7_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23122">
        <property type="entry name" value="MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02828">
        <property type="entry name" value="L27"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00569">
        <property type="entry name" value="L27"/>
        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="L27 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51022">
        <property type="entry name" value="L27"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0965">Cell junction</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 11" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="6" id="KW-0796">Tight junction</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="L27" evidence="16">
        <location>
            <begin position="28"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="L27" evidence="16">
        <location>
            <begin position="83"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="15">
        <location>
            <begin position="157"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="13">
        <location>
            <begin position="246"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate kinase-like" evidence="14">
        <location>
            <begin position="406"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005003724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="614" mass="70075" checksum="96649B58639EBCDA" modified="2022-01-19" version="1">MLQAANYTELLSEINEITPRLHFVFYFHFIGLYELLAALPAQLQPHVDSQEDLTFLWDMFGEKSLHSLVKIHEKLHYYEKQNPVPILHGAAALADDLAEELQSKPLNSEIRELLKLLSKPNLKALLSVHDTVAQKNYDPVLPPMPDDIDEEEDSVKIIRLVKNREPLGATIKRDEHTGAIVVARIMRGGAADRSGLVHVGDELREVNGIAVLHKRPEEIIHILAQSQGAITFKIIPSVKEETPSKEGKMFIRALFDYDPNEDKAIPCKEAGLAFRKGDILQIMSQDDATWWQAKHEGDANPRAGLIPSKHFQESTSVFFAGLLTILLYFLALILCAFTLRPEDAECAGHNSGSYLAGFRRSFRLSRKDKKTNKSMYECKKSDQYDTADIPTYEEVAKYRRQPNDKYRLVVLVGPVGVGLNELKRKLLISDTQHYGVTVPHTTRARRSQESDGVEYIFISKHLFETDVQNNKFIEYGEYKNNYYGTSLDSVRSVLAKNKVCLLDVQPHVMKHLRTYEFKPFVIFIKPPPLDRLRETRKNAKIISSKDDRGTAKPFTEEDFQEMIKSAQVMESQYGHLFDKVIVNDDLATAYSELKATFDRLETETFWVPVSWLHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SYV2</accession>
    <name>A0A8C2SYV2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SYV2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005009384.1">
        <property type="protein sequence ID" value="ENSCJPP00005005873.1"/>
        <property type="gene ID" value="ENSCJPG00005005551.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01130000278319"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
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        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052598">
        <property type="entry name" value="IgSF_CEA-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44337">
        <property type="entry name" value="CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44337:SF23">
        <property type="entry name" value="V-SET AND IMMUNOGLOBULIN DOMAIN CONTAINING 10 LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13895">
        <property type="entry name" value="Ig_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="43"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="140"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005005873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="236" mass="25617" checksum="4C59063EDE8D9D4D" modified="2022-01-19" version="1">YISMGSLYLPMGSLYLYGVSMYLYGVSMYLYGVVPQPPRGLSPTHPLPSRTPPRPEGTEVALTCTVREGTAPLGFSWQHREPHGRLLAAPVGMGGSGAELLLAPANRSHAGWYSCTARNEVNNRTSEPVYLDIVYGPDEPAISVEPFSPEQGSFSAGEREDVVLSCLAPSNPPSRYIWLHNGSQVHIGQTFVMSAIARGQAGTYTCLAENTHLQTRTQATIVLTVYCKYRGPGPAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SZE2</accession>
    <name>A0A8C2SZE2_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fission, mitochondrial 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">FIS1</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FIS1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015706236.1">
        <property type="nucleotide sequence ID" value="XM_015850750.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SZE2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005008543.1">
        <property type="protein sequence ID" value="ENSCJPP00005005221.1"/>
        <property type="gene ID" value="ENSCJPG00005005045.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107307258"/>
    <dbReference type="KEGG" id="cjo:107307258"/>
    <dbReference type="CTD" id="51024"/>
    <dbReference type="GeneTree" id="ENSGT00390000000592"/>
    <dbReference type="OrthoDB" id="421154at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043653">
        <property type="term" value="P:mitochondrial fragmentation involved in apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12212">
        <property type="entry name" value="Fis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016543">
        <property type="entry name" value="Fis1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033745">
        <property type="entry name" value="Fis1_cytosol"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028061">
        <property type="entry name" value="Fis1_TPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028058">
        <property type="entry name" value="Fis1_TPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13247:SF0">
        <property type="entry name" value="MITOCHONDRIAL FISSION 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13247">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 11 TPR REPEAT PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14853">
        <property type="entry name" value="Fis1_TPR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14852">
        <property type="entry name" value="Fis1_TPR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005005221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="138" mass="16219" checksum="B569BCABBDEC084B" modified="2022-01-19" version="1">MDPEFDDVVAPEDLMVLERRYTLACQQGAPSRRCRFEYAWGLLRSRYHGDIRKGVAMFRDLMADGDPDERRDYVYYLAVGNYRLKEYEEALKYVGALLQAEPGNTQGLRLQQLVRKRMNRGETHRNPIETHRDPIEIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T137</accession>
    <name>A0A8C2T137_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WAP four-disulfide core domain 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">WFDC2</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T137"/>
    <dbReference type="Ensembl" id="ENSCJPT00005010643.1">
        <property type="protein sequence ID" value="ENSCJPP00005006830.1"/>
        <property type="gene ID" value="ENSCJPG00005006312.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00730000111410"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019731">
        <property type="term" value="P:antibacterial humoral response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00199">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.75.10:FF:000001">
        <property type="entry name" value="Anosmin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.75.10">
        <property type="entry name" value="Elafin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036645">
        <property type="entry name" value="Elafin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008197">
        <property type="entry name" value="WAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050514">
        <property type="entry name" value="WAP_four-disulfide_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19441:SF34">
        <property type="entry name" value="WAP FOUR-DISULFIDE CORE DOMAIN PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19441">
        <property type="entry name" value="WHEY ACDIC PROTEIN WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00095">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00003">
        <property type="entry name" value="4DISULPHCORE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00217">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57256">
        <property type="entry name" value="Elafin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51390">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="WAP" evidence="7">
        <location>
            <begin position="116"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="WAP" evidence="7">
        <location>
            <begin position="161"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="54"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="56"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="212" mass="21937" checksum="599D494840426ECD" modified="2022-01-19" version="1">MQRAALGCCSCRASFLRRRLGSSRLPLPGQLPAASRYLILGDCAMARRGSLAQPVPYEPPGRQSPPAPPGEELKAQPGGPARAQLPCTMPKASSVLLFAGLLVLGSELLPASVLNVTIKAGVCPEPAAEEANCTLGCQSDGDCESTLKCCPAACGKACQEPNEKPGTCPAVKPGIPMLGLCVNQCKTDSNCSGIMKCCRNGCGKISCMTPLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T3A6</accession>
    <name>A0A8C2T3A6_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transmembrane protein 45B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC107324303</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM45 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015739719.1">
        <property type="nucleotide sequence ID" value="XM_015884233.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015739720.1">
        <property type="nucleotide sequence ID" value="XM_015884234.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T3A6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005010310.1">
        <property type="protein sequence ID" value="ENSCJPP00005006549.1"/>
        <property type="gene ID" value="ENSCJPG00005006117.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107324303"/>
    <dbReference type="KEGG" id="cjo:107324303"/>
    <dbReference type="GeneTree" id="ENSGT00940000157181"/>
    <dbReference type="OrthoDB" id="551896at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006904">
        <property type="entry name" value="DUF716"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042127">
        <property type="entry name" value="TMEM45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16007">
        <property type="entry name" value="EPIDIDYMAL MEMBRANE PROTEIN E9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16007:SF21">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 45A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04819">
        <property type="entry name" value="DUF716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="284" mass="31788" checksum="4FFC9108D2A1E275" modified="2022-01-19" version="1">MPTSFLGCALRGTFFLIFGLWWSVRYPLKYLRRKTNAENQPSYGLQRVEVFEGAIKAFFALAGILVEQFVPSGPHLMLYSPKTHSWTDLTHWHYTTMYLFFLLSGIVDVVSHSPLKLPLGLDRLSLSVALFMEGLLFCFHDYGDAALDQHLHSLMAFAIFAGALCVLLEVFIRDHIILECLRTSTFLLQGSWLWQIGFVLSPPWGGPGWDQTDSSNFSFLTMCFCWHYAGALFTLAANAAASRCCNESCQLRFGDIDVELDCGLCLRKKGSGGALLPEGGTEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T3C7</accession>
    <name>A0A8C2T3C7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Frizzled-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">FZD1</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor Fz/Smo family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T3C7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005010092.1">
        <property type="protein sequence ID" value="ENSCJPP00005006402.1"/>
        <property type="gene ID" value="ENSCJPG00005005989.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162584"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005109">
        <property type="term" value="F:frizzled binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030165">
        <property type="term" value="F:PDZ domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042813">
        <property type="term" value="F:Wnt receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017147">
        <property type="term" value="F:Wnt-protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036520">
        <property type="term" value="P:astrocyte-dopaminergic neuron signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035425">
        <property type="term" value="P:autocrine signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045446">
        <property type="term" value="P:endothelial cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060022">
        <property type="term" value="P:hard palate development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003149">
        <property type="term" value="P:membranous septum morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003150">
        <property type="term" value="P:muscular septum morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030514">
        <property type="term" value="P:negative regulation of BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903377">
        <property type="term" value="P:negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035567">
        <property type="term" value="P:non-canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003151">
        <property type="term" value="P:outflow tract morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045669">
        <property type="term" value="P:positive regulation of osteoblast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000739">
        <property type="term" value="P:regulation of mesenchymal stem cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905606">
        <property type="term" value="P:regulation of presynapse assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009410">
        <property type="term" value="P:response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd07458">
        <property type="entry name" value="CRD_FZ1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.2000.10:FF:000003">
        <property type="entry name" value="Frizzled class receptor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000029">
        <property type="entry name" value="Frizzled class receptor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2000.10">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015526">
        <property type="entry name" value="Frizzled/SFRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000539">
        <property type="entry name" value="Frizzled/Smoothened_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020067">
        <property type="entry name" value="Frizzled_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036790">
        <property type="entry name" value="Frizzled_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309">
        <property type="entry name" value="FRIZZLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309:SF81">
        <property type="entry name" value="FRIZZLED-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01534">
        <property type="entry name" value="Frizzled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01392">
        <property type="entry name" value="Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00489">
        <property type="entry name" value="FRIZZLED"/>
    </dbReference>
    <dbReference type="SMART" id="SM00063">
        <property type="entry name" value="FRI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01330">
        <property type="entry name" value="Frizzled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63501">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50038">
        <property type="entry name" value="FZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="12 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 19" id="KW-0732">Signal</keyword>
    <keyword evidence="15" id="KW-0807">Transducer</keyword>
    <keyword evidence="7 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034588550" description="Frizzled-1" evidence="19">
        <location>
            <begin position="34"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="338"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="471"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="530"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="FZ" evidence="20">
        <location>
            <begin position="50"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="21">
        <location>
            <begin position="251"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="173"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="17">
        <location>
            <begin position="192"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="55"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="63"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="577" mass="64131" checksum="FAB73E78855855E9" modified="2022-01-19" version="1">TVPYAGKFGRGPRRPPALPLLLLLWAAALPAGGQPAAQPAALSERGISVPDHGFCQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSAELKFFLCSMYAPVCTVLEQALPPCRSLCERARQGCEALMNKFGFQWPERLRCENFPVHGAGEICVGQNASERGTPTPALRPESWTSNPQRGGGAGGSGPGEARGRFSCPRALKVPAYLNYRFLGEKDCGAPCEPGRPYGLMYFGPEELRFSRTWIGIWSVLCCASTLFTVLTYLVDMQRFSYPERPIIFLSGCYTAVAVAYIAGFLLEERVVCNERFAEDGSRTVAQGTKREGCTILFMMLYFFGMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQVDGDVLSGVCFVGINSVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLEKLMVRIGVFSVLYTVPATIVIACYFYEQAFREQWERSWVTQSCKSYAIPCPNNHSSHHPPMSPDFTVFMIKYLMTLIVGITSGFWIWSGKTLQSWRKFYTRLTNSKQGETTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T3T7</accession>
    <name>A0A8C2T3T7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP-5 complex subunit mu-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Adaptor-related protein complex 5 subunit mu-1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">AP5M1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="5">Probably part of the adaptor protein complex 5 (AP-5) a tetramer composed of AP5B1, AP5M1, AP5S1 and AP5Z1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Lysosome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015721356.2">
        <property type="nucleotide sequence ID" value="XM_015865870.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T3T7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005010380.1">
        <property type="protein sequence ID" value="ENSCJPP00005006606.1"/>
        <property type="gene ID" value="ENSCJPG00005006162.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107315458"/>
    <dbReference type="KEGG" id="cjo:107315458"/>
    <dbReference type="CTD" id="55745"/>
    <dbReference type="GeneTree" id="ENSGT00390000006191"/>
    <dbReference type="OrthoDB" id="1877176at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030119">
        <property type="term" value="C:AP-type membrane coat adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09256">
        <property type="entry name" value="AP_MuD_MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1170:FF:000014">
        <property type="entry name" value="AP-5 complex subunit mu-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039591">
        <property type="entry name" value="AP5M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16082">
        <property type="entry name" value="AP-5 COMPLEX SUBUNIT MU-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16082:SF2">
        <property type="entry name" value="AP-5 COMPLEX SUBUNIT MU-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
    <keyword evidence="12" id="KW-0458">Lysosome</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="15">
        <location>
            <begin position="260"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="543" mass="60146" checksum="334F93E8AD11DDFE" modified="2022-01-19" version="1">MSSALLSGPQPPHRCRPLCPGTAAPASALRKWPRVTTGSSPVASTRHGPARPGCPRCRVMALRALWVLRYEPRAVLFSRRYPTVEARAEALNGSTHVAVPPDSDFLKAMLFELRLTDDQSFVEHRDTCTRIDHSSVHSVRVEGGDLWPVVAFKKSGLIYACLPLVEDALEPRPPLLTIPGLSQGLALLFGILDYISPSRKNEAELSAKASQLRTLIIQACPLGTPLNTNISSLSSSFDDIQVVPTDAKQPAWRSNTYKGKPQVNVCITEKVKCMQYDKRDVVDMWQVYGAVNCKCDIEGAAPNVTLTLNLPTNGSPLQDIIVHHCVTSVDPAMLMSSSVNPLDDSVYSGPYKFPFIPPSESFNLCYYTSQVPVPPILGCYQLIEEGSHLKITVNLKLHESIKNSFEYCEARIPFFNRGPIAHLEYKVSYGQLDLSREKSILVWVIGQKFPKSLEVSLTGTVSFGAVGEEHPTDYVCTGNTAYVKMYFRIPDFTLTGCYVDQHSVQIFVPGKPKITASRELISSDYYIWNSEASAPTMYKSLYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T406</accession>
    <name>A0A8C2T406_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FERM and PDZ domain containing 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FRMPD1</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015705556.1">
        <property type="nucleotide sequence ID" value="XM_015850070.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005010481.1">
        <property type="protein sequence ID" value="ENSCJPP00005006690.1"/>
        <property type="gene ID" value="ENSCJPG00005006207.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107306731"/>
    <dbReference type="KEGG" id="cjo:107306731"/>
    <dbReference type="CTD" id="22844"/>
    <dbReference type="GeneTree" id="ENSGT00950000183035"/>
    <dbReference type="OrthoDB" id="5859304at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome Z"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090150">
        <property type="term" value="P:establishment of protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008277">
        <property type="term" value="P:regulation of G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17168">
        <property type="entry name" value="FERM_F1_FRMPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06769">
        <property type="entry name" value="PDZ_FRMPD1_3_4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000203">
        <property type="entry name" value="FERM and PDZ domain containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000009">
        <property type="entry name" value="FERM and PDZ domain containing 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000066">
        <property type="entry name" value="FERM and PDZ domain-containing protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46221:SF2">
        <property type="entry name" value="FERM AND PDZ DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46221">
        <property type="entry name" value="FERM AND PDZ DOMAIN-CONTAINING PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21989">
        <property type="entry name" value="RA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="57"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="FERM" evidence="2">
        <location>
            <begin position="181"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="513"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="859"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1176"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="549"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="580"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="594"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="886"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1199"/>
            <end position="1210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1366" mass="150767" checksum="BBAEEF8C1E14B2BB" modified="2022-01-19" version="1">MEDLETNLIQTRKACRIEQMVAKWLHRSRDGASSGRVSVTDVSSDGGAQAISRVKLTVTVYKDLVLHHYGFEICPDLPLTIASVTAGSTADGKLLPGDQLLRINSTMVEDMSIERVADIIRDAGDELLLTVIRCTSGGPKSSFLTEEKRARLKTNPVKVRFAEEVLVNGHSQGNSLLCMPNVLKVYLENGQTKAFRFETSTTVKDIVLTLKEKLSIRSIAHFALTLEEQYNASKIHLLHEEELIEQVVQKRESHDCRCLFRICFVPKDPLDLLQEDPVAFEYLYLQSCSDVLQERFAVEMKCSVALRLAALQIQERIYTCAQPQKVSLKYIERDWGIENFISPTLLRNMRGKDIKKAISYHMKRNQVLLDPRQKHMLAAVQVRLNYLQILGDLKMYSGKIFNATLMLQDRESYVALLVGAKHGVSQIINSKLSIITSLAEFSNISRVEMTEESEKVSMVKIYLQDLKLLTLLLESNSAKDLVCLIVGYYRLFVDANVSVFTWGEKRQQLHRVSAEEGYESRTCSDSEDSWEMDSSSEHCLGIHSSTHPVSEEKMGELQSLEKDSTEPQPIGNYLRDGGDNADSTSDASDSANTESRGFKTSGSSDSMDALEEDELEACSSSRPEFFHFYTPTVHEMNSLDKSFPICAAGGSGGSEARDFFCFLQVPEADKHGCKHSPCEQKGVDSDVSVLRTKLSERNSMDYYSLCCSISPAGSVERSSISHNHNRSPWKDESAHDEVPWGAEQMAEVSDLILEPPLGFGDTSSEEEFYDAADRLSPPCSLPAGCQATSQESAEDNCILQKPRCYSLGENSISREKYGEEKQLMYSKSLRKRRSFLKTNYTSQVTFPLALPGSSQSCCSWPPTPALPAQSSDPSSSDKDAEMGTPAPQTQTDIAGTKSSSGVMEMEPDTMEIKSVTDLVVSSISAVRLQGDHREESADVAVDVGQLSRAAHAVHPNSLFQEEAVHQEQSSAIKESPTVKWPSDESCVTTRDQPAQAAPEGECDVMEPTHKAGNVPPFQGQEMVCPADECTLPPSSCSASPHGVAKEQDLLPTVWRQMGCEESVLVPCGEGKANLDFCAENRRDSALSQAKSRQAISTEALREVYNKNELGFPDVTQLLANNSSSSGVIAQLSWLTVQVRSDLISPNPTQNRRHDPLELLDSQRSAVCVGDDAVRKEMQTSSATLSPEKELESKNGMVEGEPRKDTEDAAHEHHCPVQTPFLGEQSAIVGKDSLQTRELSISPNSIPLGSLGKTGDCVDSNPSFLCFNHKKDERDAAAGSILTRSLGFSVMRKTSAQFGMDKCSCQLSYVSCFHRPDEDRKQETTVPMCSVFLQPVTTPPSTSCSPPIVTGQSVSAEEPRHITFTYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T4N5</accession>
    <name>A0A8C2T4N5_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Neudesin neurotrophic factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">NENF</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015712805.1">
        <property type="nucleotide sequence ID" value="XM_015857319.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T4N5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005012653.1">
        <property type="protein sequence ID" value="ENSCJPP00005008313.1"/>
        <property type="gene ID" value="ENSCJPG00005007470.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107311077"/>
    <dbReference type="KEGG" id="cjo:107311077"/>
    <dbReference type="CTD" id="29937"/>
    <dbReference type="GeneTree" id="ENSGT00940000162504"/>
    <dbReference type="OrthoDB" id="10069062at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000165">
        <property type="term" value="P:MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032099">
        <property type="term" value="P:negative regulation of appetite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF72">
        <property type="entry name" value="NEUDESIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034811550" evidence="7">
        <location>
            <begin position="28"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="8">
        <location>
            <begin position="46"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005008313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="171" mass="18860" checksum="C0179A9BA5F90B60" modified="2022-01-19" version="1">MAGGGAERPLCASVLMAVLVLAGLAAAERELRFKAPPRTEVPVRLFTEHELARYDGQQEGQPIYLAVKGVVFDVTSGKEFYGKGAPYNALVGKDSTRGVAKMSLDPADLTHDITGLTEEELKSLDEVFNNVYKAKYPIVGYTSRRILNEDGSPNLEFKPEDQPHFNIRDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T645</accession>
    <name>A0A8C2T645_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nuclear factor of activated T cells 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">NFATC2</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T645"/>
    <dbReference type="Ensembl" id="ENSCJPT00005012347.1">
        <property type="protein sequence ID" value="ENSCJPP00005008080.1"/>
        <property type="gene ID" value="ENSCJPG00005007292.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156230"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035976">
        <property type="term" value="C:transcription factor AP-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019902">
        <property type="term" value="F:phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050853">
        <property type="term" value="P:B cell receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033173">
        <property type="term" value="P:calcineurin-NFAT signaling cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051216">
        <property type="term" value="P:cartilage development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071277">
        <property type="term" value="P:cellular response to calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140742">
        <property type="term" value="P:lncRNA transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014904">
        <property type="term" value="P:myotube cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905064">
        <property type="term" value="P:negative regulation of vascular associated smooth muscle cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030890">
        <property type="term" value="P:positive regulation of B cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901741">
        <property type="term" value="P:positive regulation of myoblast fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009410">
        <property type="term" value="P:response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.340:FF:000001">
        <property type="entry name" value="Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.340">
        <property type="entry name" value="Rel homology domain (RHD), DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008366">
        <property type="entry name" value="NFAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011539">
        <property type="entry name" value="RHD_DNA_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037059">
        <property type="entry name" value="RHD_DNA_bind_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12533">
        <property type="entry name" value="NFAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12533:SF4">
        <property type="entry name" value="NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00554">
        <property type="entry name" value="RHD_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01789">
        <property type="entry name" value="NUCFACTORATC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50254">
        <property type="entry name" value="REL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RHD" evidence="2">
        <location>
            <begin position="302"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005008080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="510" mass="55476" checksum="5C032125448C9BA9" modified="2022-01-19" version="1">MGRYGQPDSIGTAPTHPASAAGASAPSPRIEITSYPELINSGGPFRSRDTDVLLVEHQSNSATTSPRVTLPVPGFEGYREPLCLSPASSGSSASFISETNLSPCTSPCVSPNNGPSDDLCPQFQNIHTHYSPRTSPIMSPRTSITEETCLGQHSPSPRPNSRSSSPGAKRRYSCTQQPSTSPRQSRTPSPQSSPRIPLREDSSTVTYTQLSSAPLSMDAMSSLPTDPSCGVPTKIWKTSPDPSSMPSHKNSIPCHVFQTVDFHGPCEQEDRRNSAPESILLVPPSWTKQLMPAIPICSLPVQSLPPLEWPLSSQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTGGHPVVQLHGYMENKPLGLQIFIGTADERILKPHAFYQVHRITGKTVTTTSYEKIIGNTKVLEIPLEPKNNMKATIDCAGILKLRNADIELRKGETDIGRKNTRVRLVFRVHIPESSGRIISLQAASNPIECCKYPLRSAWSQHGCADRVEMHRAVRAGGCVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T6B9</accession>
    <name>A0A8C2T6B9_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DnaJ homolog subfamily B member 13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Proteasomal ATPase-associated factor 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Testis and spermatogenesis cell-related protein 6</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Testis spermatocyte apoptosis-related gene 6 protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Testis spermatogenesis apoptosis-related gene 3 protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Testis spermatogenesis apoptosis-related gene 6 protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">WD repeat-containing protein 71</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">PAAF1</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Functions as part of axonemal radial spoke complexes that play an important part in the motility of sperm and cilia.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer. Component of the axonemal radial spoke complex 1 (RS1), at least composed of spoke head proteins RSPH1, RSPH3, RSPH9 and the cilia-specific component RSPH4A or sperm-specific component RSPH6A, spoke stalk proteins RSPH14, DNAJB13, DYDC1, ROPN1L and NME5, and the anchor protein IQUB. Interacts with SUN5. Interacts with IQUB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
            <location evidence="1">Flagellum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the WD repeat PAAF1/RPN14 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T6B9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005010803.1">
        <property type="protein sequence ID" value="ENSCJPP00005006937.1"/>
        <property type="gene ID" value="ENSCJPG00005006417.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000005948"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036126">
        <property type="term" value="C:sperm flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030030">
        <property type="term" value="P:cell projection organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000002">
        <property type="entry name" value="Dnaj homolog subfamily b member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000033">
        <property type="entry name" value="dnaJ homolog subfamily B member 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000006">
        <property type="entry name" value="DnaJ subfamily B member 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000181">
        <property type="entry name" value="Proteasomal ATPase associated factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000212">
        <property type="entry name" value="Proteasomal ATPase associated factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051339">
        <property type="entry name" value="DnaJ_subfamily_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078:SF519">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="4" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-0282">Flagellum</keyword>
    <keyword evidence="6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 20" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="20">
        <location>
            <begin position="116"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="20">
        <location>
            <begin position="158"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="20">
        <location>
            <begin position="200"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="22">
        <location>
            <begin position="428"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00056649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00064985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00068927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00071910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00075378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00075753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00078669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00080190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00081125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="740" mass="81683" checksum="EF8DB24DA063F9C1" modified="2022-01-19" version="1">MWLRTSHTPMTGRRKAEEEGGGCRLKMMAAATLRIQSDWSQALRRDEGEAWLSCRSPGKPTLYGSLTRRGLSSEGVPDIAASEGFVVGEVTKKSILISCPHENVSTKFLAPYTTFARIHQKSITCLDISSGGGLGVSTSTDGTMKIWQAANGEIRRLLEGHVYDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVLSCSRDGTARLWDCGKSSCLGVIADCGSPINGIAVGTADDSVNLGTPEKAPSEREIGTEGKILLLAREDKKLQGVGLQSRQPVFLFDGSDAFNCCTFLSSTYFLAGTQDGNIYQLDVRNTNAPIQIIHRSGAPVLSLLPYRDGFIASQGDGTCFIIQQDLDYVIDLTEADCDPVYKVAQWEKQIYTCCRDGVVRRYQLGDLEEAAMGQDYYAVLELGRQATDADIKKAYRLLALENHPQKCREPEAQERFRLLAEAYDVLSDPVRRGIYDRFGEEGLKGGVPVESGSEDAWTPGYVFHNNPDRVFKEFFGGHNPFAEFFTKDGVEATLPFGGLRGRGVMKQDPPMVWDLHVSLEDLFFGCTKKMKISRRVMNEDGQTSTIRDKILIIDVQPGWKQGTRITFEKEGDQGPNIIPADIIFVIQEKPHPRFKRSNDDLIYVANIPLGKALIGCTVEVRTLDGRLLNIPINDIVHPTYCKVVPGEGMPLLKDPHQKGDLLIQFNVCFPKRLSPNKKVLLKRALLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T6S1</accession>
    <name>A0A8C2T6S1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein VAC14 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">VAC14</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Scaffold protein component of the PI(3,5)P2 regulatory complex which regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Pentamerizes into a star-shaped structure and nucleates the assembly of the complex. The pentamer binds a single copy each of PIKFYVE and FIG4 and coordinates both PIKfyve kinase activity and FIG4 phosphatase activity, being required to maintain normal levels of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 5-phosphate (PtdIns(5)P). Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Forms pentamers. Component of the PI(3,5)P2 regulatory complex/PAS complex, at least composed of PIKFYVE, FIG4 and VAC14. VAC14 nucleates the assembly of the complex and serves as a scaffold by pentamerizing into a star-shaped structure, which can bind a single copy each of PIKFYVE and FIG4 and coordinates their activities. Interacts with NOS1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Microsome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VAC14 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015729339.1">
        <property type="nucleotide sequence ID" value="XM_015873853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T6S1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005012661.1">
        <property type="protein sequence ID" value="ENSCJPP00005008321.1"/>
        <property type="gene ID" value="ENSCJPG00005007146.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107319182"/>
    <dbReference type="KEGG" id="cjo:107319182"/>
    <dbReference type="CTD" id="55697"/>
    <dbReference type="GeneTree" id="ENSGT00390000008385"/>
    <dbReference type="OrthoDB" id="5574975at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070772">
        <property type="term" value="C:PAS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098830">
        <property type="term" value="C:presynaptic endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006661">
        <property type="term" value="P:phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099149">
        <property type="term" value="P:regulation of postsynaptic neurotransmitter receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000631">
        <property type="entry name" value="Vac14, PIKFYVE complex component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026825">
        <property type="entry name" value="Vac14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021841">
        <property type="entry name" value="VAC14_Fig4p-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16023:SF0">
        <property type="entry name" value="PROTEIN VAC14 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16023">
        <property type="entry name" value="TAX1 BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12755">
        <property type="entry name" value="Vac14_Fab1_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11916">
        <property type="entry name" value="Vac14_Fig4_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Vacuolar protein 14 C-terminal Fig4-binding" evidence="13">
        <location>
            <begin position="540"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="348"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="362"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF11916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005008321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="780" mass="87953" checksum="7DB7E64D97470DBB" modified="2022-01-19" version="1">MNAERDLAPLAPSVVRALNDKLYEKRKVAALEIEKLVREFVAQNNTSQIKHVILILSQEFALSQHPHSRKGGLIGLAACSIALGKDSGLYLKELIEPVLTCFNDADSRLRYYACEALYNIVKVARGSVLPHFNVLFDGLSKLAADPDPNVKSGSELLDRLLKDIVTESNQFDLVGFIPLLRERIYSNNQYARQFIISWILVLESVPDINLLDYLPEILDGLFQILGDNSKEIRKMCEVALGEFLKEIKKNPSSVKFAEMANILVIHCQAADDLIQLTAMCWMREFIQLAGRVMLPYSSGILTAVLPCLSYDDRKKNIKEVANVCNQSLMKLVIPEDDEMDEAKQSITLSAEPNPEEPITKPEAASSGSLEASGESNVSNASVCTVTSSERIQVTLNLDGIVQVLDCHLHDTSIGMMTRIAVLKWLYHLYIKTPRKMFRHTDSLFPILLRTLSDESDEVILKDLEVLAEIASSPAGQTEGYGPSEAAEPRPSQVELHVPIRNSQLSSSGPKGLECSPSTPTMNSYFYKFMINLLRRFSSERKLLETRGAFIIRQLCLLLNAENIFHSMADILLREEDLKFASTMVHTLNTILLTSSELFQLRNQLKDLRTPESRNLFCCLYRSWCHNPVTTVSLCFLTQNYKHAYDLIQKFGDLEVTVDFLTEVDKLVQLIECPIFTYLRLQLLDVKNNPYLIKALYGLLMLLPQSSAFQLLSHRLQCVPNPELMQSADSSRASSSSRRPASSTIDYTELLQHFDKVQSKHLEVRHQRAGRAEQPERRVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T7L3</accession>
    <name>A0A8C2T7L3_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">KLF transcription factor 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">KLF9</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the Sp1 C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015704618.1">
        <property type="nucleotide sequence ID" value="XM_015849132.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T7L3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005013116.1">
        <property type="protein sequence ID" value="ENSCJPP00005008680.1"/>
        <property type="gene ID" value="ENSCJPG00005007737.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107306203"/>
    <dbReference type="KEGG" id="cjo:107306203"/>
    <dbReference type="CTD" id="687"/>
    <dbReference type="GeneTree" id="ENSGT00940000160905"/>
    <dbReference type="OrthoDB" id="6365676at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome Z"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071387">
        <property type="term" value="P:cellular response to cortisol stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007623">
        <property type="term" value="P:circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010839">
        <property type="term" value="P:negative regulation of keratinocyte proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd21578">
        <property type="entry name" value="KLF9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000018">
        <property type="entry name" value="Krueppel-like factor 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000232">
        <property type="entry name" value="Krueppel-like factor 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000521">
        <property type="entry name" value="Krueppel-like factor 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF132">
        <property type="entry name" value="KRUEPPEL-LIKE FACTOR 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="134"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="164"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="194"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="80"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="213"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005008680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="235" mass="25723" checksum="CA7B156972E8255F" modified="2022-01-19" version="1">MSAVAYVDFVAAQCLVSISNRSAGPPSPEAAARLKVPGEAETGREMRDPRDAWKDYCALLAIAKSLLELNKYRPLPAPSVCSDSLESPDEDAGSDSDAAATSPCSGPEPAPPSRLRGAAAAAAPKAKLAAEKRHKCPYSGCGKVYGKSSHLKAHYRVHTGERPFPCTWPDCLKKFSRSDELTRHYRTHTGEKQFRCPLCEKRFMRSDHLTKHARRHTEFHPSMIKRSKKSSSGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T7X1</accession>
    <name>A0A8C2T7X1_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Potassium inwardly rectifying channel subfamily J member 15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">KCNJ15</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 15">Membrane</location>
            <topology evidence="1 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015737998.1">
        <property type="nucleotide sequence ID" value="XM_015882512.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T7X1"/>
    <dbReference type="SMR" id="A0A8C2T7X1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005013463.1">
        <property type="protein sequence ID" value="ENSCJPP00005008954.1"/>
        <property type="gene ID" value="ENSCJPG00005007938.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107323438"/>
    <dbReference type="KEGG" id="cjo:107323438"/>
    <dbReference type="CTD" id="3772"/>
    <dbReference type="GeneTree" id="ENSGT01140000282491"/>
    <dbReference type="OrthoDB" id="273257at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005242">
        <property type="term" value="F:inward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034765">
        <property type="term" value="P:regulation of monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000036">
        <property type="entry name" value="ATP-sensitive inward rectifier potassium channel 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1400:FF:000002">
        <property type="entry name" value="ATP-sensitive inward rectifier potassium channel 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1400">
        <property type="entry name" value="G protein-activated inward rectifier potassium channel 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041647">
        <property type="entry name" value="IRK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016449">
        <property type="entry name" value="K_chnl_inward-rec_Kir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003270">
        <property type="entry name" value="K_chnl_inward-rec_Kir1.3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013518">
        <property type="entry name" value="K_chnl_inward-rec_Kir_cyto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040445">
        <property type="entry name" value="Kir_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767:SF20">
        <property type="entry name" value="ATP-SENSITIVE INWARD RECTIFIER POTASSIUM CHANNEL 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767">
        <property type="entry name" value="INWARD RECTIFIER POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01007">
        <property type="entry name" value="IRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17655">
        <property type="entry name" value="IRK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005465">
        <property type="entry name" value="GIRK_kir"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01323">
        <property type="entry name" value="KIR13CHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01320">
        <property type="entry name" value="KIRCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12 15" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10 15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0630">Potassium</keyword>
    <keyword evidence="5 15" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 15" id="KW-0813">Transport</keyword>
    <keyword evidence="7 15" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel inwardly rectifying transmembrane" evidence="17">
        <location>
            <begin position="58"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Inward rectifier potassium channel C-terminal" evidence="18">
        <location>
            <begin position="206"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="site" description="Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesium" evidence="14">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR005465-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF17655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005008954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="403" mass="46102" checksum="3788467DD9074E21" modified="2022-01-19" version="1">MSLFRALKKTFAVVKKSLFSKETTEAVRMEATQINMSRVPLVNGGISTALKAHKPRVMSKSGHSNVRIDKVDGIYLLYLQDLWTTVIDMKWRYKLTLFAATFVMTWFLFGVIYYAIAFLHGDLEINKFTSKREPCVKNVDSLTGAFLFSLESQTTIGYGFRFITEECPHAIFLLVAQLVITTLIEIFITGTFLAKIARPKKRAETIKFSHCAVITKHNGELCLVIRVANMRKSLLIQCQLSGKLLQTYETKEGERILLNQASVKFNVDSSSESPFLILPLTFYHILDESSPLRDLTPQNLKDKDFELVVLLNATVESTSAVCQSRTSYIPDEIHWGYEFVPVVSLSPNGKYVADFSQFEKIRRSTDSSFYSVDSEKQKLEEKYRQEDQRERELRTMLLQQSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T9U3</accession>
    <name>A0A8C2T9U3_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tomoregulin-2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Transmembrane protein with EGF-like and two follistatin-like domains</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">TMEFF2</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the tomoregulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T9U3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005014611.1">
        <property type="protein sequence ID" value="ENSCJPP00005009818.1"/>
        <property type="gene ID" value="ENSCJPG00005008593.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156056"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030336">
        <property type="term" value="P:negative regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045720">
        <property type="term" value="P:negative regulation of integrin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051497">
        <property type="term" value="P:negative regulation of stress fiber assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044319">
        <property type="term" value="P:wound healing, spreading of cells"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00104">
        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000234">
        <property type="entry name" value="tomoregulin-2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.30:FF:000002">
        <property type="entry name" value="tomoregulin-2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.30:FF:000020">
        <property type="entry name" value="tomoregulin-2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21632">
        <property type="entry name" value="REGULATORY PROTEIN ZESTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21632:SF5">
        <property type="entry name" value="TOMOREGULIN-2 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 14" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0654">Proteoglycan</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="18">
        <location>
            <begin position="92"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="18">
        <location>
            <begin position="183"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="17">
        <location>
            <begin position="263"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="358"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00076713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005009818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="376" mass="41276" checksum="34934A5FA0C3433A" modified="2022-01-19" version="1">MVLCEPSAPRQCGGWTLCDCCCWLLLPAALLLLLARPDKLAAFPTSLSDCQTPTGWNCSGYDDRENDLFLCDTNTCKFDGECLRIGDSVTCVCQFKCNNDYVPVCGSNGDTYQNECYLKQAACKQQSEILLVSEGSCATDAGSGSGDGVNEGSGETNQKETSTCDICQFGAECDEDAEDVWCVCNIDCSQTNFNPLCASDGKSYDNACQIKEASCQKQEKIEVMSLGRCQDNTTTTTKSEDGHYARTDYAENANKLEESARGIYIPCPEHYNGFCMHGKCEHSTNMLEPSCRCDAGYTGQHCEKKDYSVLYVVPGPVRFQYVLIAAVIGTIQIAIICVVVLCITRKCPRSNRIHRQKQNTGHYSSDNTTRASTRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TA76</accession>
    <name>A0A8C2TA76_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">G-protein coupled receptor family C group 6 member A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">GPRC6A</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">Homodimer; disulfide-linked.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015714073.1">
        <property type="nucleotide sequence ID" value="XM_015858587.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TA76"/>
    <dbReference type="Ensembl" id="ENSCJPT00005015656.1">
        <property type="protein sequence ID" value="ENSCJPP00005010605.1"/>
        <property type="gene ID" value="ENSCJPG00005009204.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107311768"/>
    <dbReference type="KEGG" id="cjo:107311768"/>
    <dbReference type="CTD" id="222545"/>
    <dbReference type="GeneTree" id="ENSGT00940000158416"/>
    <dbReference type="OrthoDB" id="425344at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035774">
        <property type="term" value="P:positive regulation of insulin secretion involved in cellular response to glucose stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000224">
        <property type="term" value="P:regulation of testosterone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043200">
        <property type="term" value="P:response to amino acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd15281">
        <property type="entry name" value="7tmC_GPRC6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000152">
        <property type="entry name" value="G protein-coupled receptor class C group 6 member A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.30:FF:000004">
        <property type="entry name" value="Taste receptor type 1 member 3-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.30">
        <property type="entry name" value="GPCR, family 3, nine cysteines domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011500">
        <property type="entry name" value="GPCR_3_9-Cys_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038550">
        <property type="entry name" value="GPCR_3_9-Cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000068">
        <property type="entry name" value="GPCR_3_Ca_sens_rcpt-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24061">
        <property type="entry name" value="CALCIUM-SENSING RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24061:SF5">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR FAMILY C GROUP 6 MEMBER A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07562">
        <property type="entry name" value="NCD3G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00592">
        <property type="entry name" value="CASENSINGR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0732">Signal</keyword>
    <keyword evidence="13" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034983101" description="G-protein coupled receptor family C group 6 member A" evidence="16">
        <location>
            <begin position="18"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="589"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="625"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="661"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="697"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="746"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="780"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="808"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="17">
        <location>
            <begin position="590"/>
            <end position="846"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005010605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="927" mass="104857" checksum="1C9BCA3DA6DADA35" modified="2022-01-19" version="1">MALFSLMLIPFVISSDAASACQNTDDFVGASSPGDIIIGGLFAVHSEMLHPEEHPIKPVIQNCAGFEIQIFLQTLAMIHAIEMINNSTLLSGVTLGYEIYDTCAEVTKAMASALRFLSKSNTSKDIVEFKCNYSDYVPRIKAVTGASYSEVSMAVSRLLALQLIPQVSPASSAEILSDKIRFPSFLRTIPSDFHQTRAMAHLICESGWNWIGVIATDDDNGRFAVESFGVQAMANSVCIAFKEMLPAYLSDNTFHTKVDRAIEKIVKETRVNVIVVFMRQFHVLKLFKKAIERKVKKIWIASDNWSTAVKISTMPNIRKLGTVVGFGFKNKDMSTFQDFLRNLHERPTENNKFLLEYIMLLSVCAHLDNYDFQMCISSQSQYDLMQNVENKQQIWRDDFLNANIEPGFIHSTILAVYAIAHAIKGQCKDRNCKDPSAFTPWELLEELKRVTIIDDDKEIKFDSKGDMSSGYDVLLWKEVDGRMEITTMAEYDPENGYFIFEDEEKKKDFLDLKKVPSTCSQHCRPGQMKKVTESPHTCCYECVYCPENHYSNRTDMDYCYRCHNKTYWAPVNSTTCYRKTIHFLGWTDWFAIFLLLLSAFGVVLIFSISAIFTKNLSTPVVKASGGLTVCYIILLSHFFIFLSTVFFIGEPTEFKCRTRQALFGISFALCISCILIKSLKILLAFSFDPKLQNFLKCAYKPIFIVFICTGIQVIICTFWLIFRTPFVKQNFSIPRAIILECNEGSVVAFGIMLGYIAALAFICFICAFKGRKLPENYNEAKFITFGMLIYFIAWIVFIPVYVTTFGKYLPAVEIIVILISNYGILCCTFFPKCYIIIYKQETNTKSAFLKMIYTYSSKSVGSVAVSQISLDSKSSSSRITASDSCNAEKSSVNGNCHFQVPGPTPVKEEDVLKKATRTLSRKRLSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TBT5</accession>
    <name>A0A8C2TBT5_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ring finger protein 220</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">RNF220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TBT5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005016579.1">
        <property type="protein sequence ID" value="ENSCJPP00005011337.1"/>
        <property type="gene ID" value="ENSCJPG00005009733.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000016573"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005652">
        <property type="term" value="C:nuclear lamina"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098794">
        <property type="term" value="C:postsynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021904">
        <property type="term" value="P:dorsal/ventral neural tube patterning"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003358">
        <property type="term" value="P:noradrenergic neuron development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090263">
        <property type="term" value="P:positive regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051865">
        <property type="term" value="P:protein autoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099149">
        <property type="term" value="P:regulation of postsynaptic neurotransmitter receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052443">
        <property type="entry name" value="E3_ubiq-ligase_RNF220-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031824">
        <property type="entry name" value="RNF220_mid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13459:SF3">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13459">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF220 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15926">
        <property type="entry name" value="RNF220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="E3 ubiquitin-protein ligase RNF220 middle" evidence="2">
        <location>
            <begin position="241"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="501"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005011337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="638" mass="71008" checksum="547A151E340F3BDD" modified="2022-01-19" version="1">MDLHRAAFKMENSPYLPNPLASPALMVLASTAEASRDASIPCQQPRPFGVPVSADKDVHIPFTNGSYTFASMYHRQGGVPGAFANRDFPPSLLHLHPQFAPPNLDCTPISMLNHSGVGAFRPFASSEDRESYQSAFTPAKRLKNCHDTDSPHLRFSDADGKEYEFGTQLPSSSPGSLKVDETGKKIFAVSGLISDRETSSSPEDRSDRYRSDSQRGPQASATATHRMILTLPLCKKKATLFDSQAPICPICQVLLRPGELQEHMEQELEKLTQLNISKNSILKDAMAAGTPKSILLSASIKREGDSPTASPHSSDDIHHSDRYQTFLRVRANRQTRLNARIGKMKRRKQDEGQVCPLCNRPLSGSEEEMSRHVEQCLAKREGSCMTEDDSVDIENENGNRFEEYEWCGQKRIRATTLLEGGFRGSGFIMCSGKENPDSDADLDVDGDDTLEYGKPQYTEADVIPCTGEEPGEAKEREALRGAVLNGGTPSTRITPEFSKWASDEMPSTSNGESSKQETMQKTCKNSDIEKITEDSAVTTFEALKARVRELERQLSRGDRYKCLICMVSSTPLVVMNQKCLDVFALSLLRREEGFLFPFFFWGENSPSSLYTMKNLFPFKCKCWFVVELGISLSVRLFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TBX4</accession>
    <name>A0A8C2TBX4_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AMP deaminase</fullName>
            <ecNumber evidence="4">3.5.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">AMPD2</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via salvage pathway; IMP from AMP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.6" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2TBX4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005015526.1">
        <property type="protein sequence ID" value="ENSCJPP00005010505.1"/>
        <property type="gene ID" value="ENSCJPG00005009134.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183011"/>
    <dbReference type="UniPathway" id="UPA00591">
        <property type="reaction ID" value="UER00663"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003876">
        <property type="term" value="F:AMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042632">
        <property type="term" value="P:cholesterol homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052652">
        <property type="term" value="P:cyclic purine nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097009">
        <property type="term" value="P:energy homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046039">
        <property type="term" value="P:GTP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072015">
        <property type="term" value="P:podocyte development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.800.20:FF:000001">
        <property type="entry name" value="AMP deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006650">
        <property type="entry name" value="A/AMP_deam_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006329">
        <property type="entry name" value="AMPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01429">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359:SF3">
        <property type="entry name" value="AMP DEAMINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19326">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00485">
        <property type="entry name" value="A_DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="865"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="743"/>
            <end position="832"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005010505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="932" mass="106052" checksum="DAB127954896F9AA" modified="2022-01-19" version="1">MAAPARFPFKKRGSLQAAGPAELRGGSRPLQSARSLPGTPHCLKHFPVDLRTSMDGKYKEIAEELFSRSMAESEMRSAPYEFPKESPIEQLEERRQRLERQISQDVKLEPDILLRAKQDFLKVDSSTDLLIYKEQHEDRVDHIPKEREALEREFQRVTISGEEKCGVPFTDLLDAAKSVVKALFLREKYMGLSLQSFCKTTARFLQELSEKPLETRSYEEVPETPVAADAAVHPPFAEQHPYEKWDPQSMPADLGFGLKMVDGVVHVYTKQDLTDKSTELDLPYPDLQEFIADMNFLMALIINGPIKSFCYRRLQYLSSKFQMHVLLNEMKELAAQKKVPHRDFYNIRKVDTHIHASSCMNQKHLLRFIKRAMKKHLDEIVHVEKGKEQTLKEVFETMNLTAYDLSVDTLDVHADRNTFHRFDKFNAKYNPIGESILREIFIKTDNRVSGKYFAHIIKEVMSDLEESKYQNAELRLSIYGRSRDEWDKLACWAVNHRVHSNNVRWLVQVPRLFDVYRTKKQLANFQEMLENIFLPLYEATIHPAQHPELHLFLEHVDGFDSVDDESKPEHHIFNLDSPLPVNWVEEDNPPYSYYLYYMYANMTVLNHLRRKRGFHTFVLRPHCGEAGPIHHLVSGFMVSENISHGLLLRKAPVLQYLYYLAQIGIAMSPLSNNSLFLSYHRNPLPEYLSRGLVVSLSTDDPLQFHFTKEPLMEEYSIATQVWKLSTCDMCELARNSVLMSGFSHKVPSPPKPQGPPHAIQVAHSHPPPGEELLAGPPLPEGRPRRERHPSYQRPRHPRWVSLRDAVPGADAHHSGCSERGAGAHPGGGRAVHHPPPTHTLPCSAIPGAPSPPAAPGCCRFPCCSLVLLVVFLVFLCFFLCVCLCLLARFFTAFPPPPPSCYTPLGGGWCCIGCCGGGSWCHSGTMGTLGVVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TC10</accession>
    <name>A0A8C2TC10_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Heart and neural crest derivatives expressed 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">HAND2</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015717314.1">
        <property type="nucleotide sequence ID" value="XM_015861828.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TC10"/>
    <dbReference type="Ensembl" id="ENSCJPT00005016882.1">
        <property type="protein sequence ID" value="ENSCJPP00005011548.1"/>
        <property type="gene ID" value="ENSCJPG00005009924.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107313507"/>
    <dbReference type="KEGG" id="cjo:107313507"/>
    <dbReference type="CTD" id="9464"/>
    <dbReference type="GeneTree" id="ENSGT00940000160772"/>
    <dbReference type="OrthoDB" id="10055449at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
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    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005010052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="731" mass="82290" checksum="E2CF59247B2CF173" modified="2022-01-19" version="1">MCSWKCSLSPGIGGTSVGTKLDPRAPTPVSAAQPLTQTHPCRHPNMASTHEEEPHAEDTADHDAHIYEEVMLCERMEHSQRLAVEELITTEASYVHNLQLCLSDIRAHLEKKQLPGLDLEGLFSNIDDILHVSRRFLRGLQDTTTQEHEQLLSISTLFQEFKEEMEMVYKIYCASYEHALLLVESYRKDPRLQEEIMDTLNATVPHTSASDLSFFLVMPVQRVTKYPLLLGKILENTPANTSTHSALAAAVRAMTQVNANINEYKRRREVATKYNKAEQLTLRDRFARLNPHSIAKKTTRLSRLLMHEAGIVAKTEDKEYDDLEERFQSVASCVTALKENMASYLKHLEAFLLPTPHKCELQMEEGPAQQYRRLAEHLHGTVFPEFRRRLDRLVWQPLCSLAEMLVGPQQLVKKRLDKLLDYEEIQERKRETGSVTYDEEAAMNTYLAINALLVAELPRFNQGAMQLLRQILGSFIVLQEDLAAEVLHEANKELEQMPHGHMPLPAFWRMVEDTLQQSGIQLRTFIQAFETVTPNPVPQPLNPAEERKVRSLVSKHGPDKLYQVTSNVSGSKDMDLTLQRGQIVALLQSVDTKGNTGRWLVDAGGPRGFVPASKLQPYSPGPSQQPSMKTSALEIGTEGRRHSYVPPEAPKPQAATFTPAFQVVAGFSFTARSPQELTLQAGQPVVVLEPHDKKGSTEWSLVEVNGQRGYVPSSYLLTVPVQEPVGWSLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TCY3</accession>
    <name>A0A8C2TCY3_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chondroitin sulfate proteoglycan 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">CSPG5</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TCY3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005017233.1">
        <property type="protein sequence ID" value="ENSCJPP00005011829.1"/>
        <property type="gene ID" value="ENSCJPG00005010113.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00440000034270"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098982">
        <property type="term" value="C:GABA-ergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030660">
        <property type="term" value="C:Golgi-associated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048858">
        <property type="term" value="P:cell projection morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000300">
        <property type="term" value="P:regulation of synaptic vesicle exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010555">
        <property type="entry name" value="CSPG5_S_attach_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009505">
        <property type="entry name" value="Neural_ProG_Cyt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15381:SF1">
        <property type="entry name" value="CHONDROITIN SULFATE PROTEOGLYCAN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15381">
        <property type="entry name" value="CHONDROITIN SULFATE PROTEOGLYCAN 5 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06566">
        <property type="entry name" value="Chon_Sulph_att"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06567">
        <property type="entry name" value="Neural_ProG_Cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="468"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="CSPG5 sulphate attachment" evidence="3">
        <location>
            <begin position="61"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Neural chondroitin sulphate proteoglycan cytoplasmic" evidence="4">
        <location>
            <begin position="496"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="527"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="157"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="532"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005011829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="585" mass="60528" checksum="19AC1478A3AB47A6" modified="2022-01-19" version="1">MAAPPAPCAWGGAASDTAPSLCPAAPEWPPRNGSAGRAWGSPLHSAAPINGTDPLGPQLEPPGGDPATADPALGCVGCSADGAASSVPPDAAQDPRLGVTSDGDGGAVALGSPEEVGSGEQPTRAGVGPTEGLTPGPPGLPSPGLGLSSTRPHLDLPDPNLGLPNPSLGLPSPGPTPDHPIPNPNPNLDLPNPNPSLGVPTPNLGLSNPNIPLPSPSPGPGTEPNILPVAEDSEVPMELPHPSSSPAPAQRARGRTDRTWLGAAEPISAAPGTAEPPEIIDVDYYDVFDGGEGPGGGHGAGGGAQREPGGAATPWGLHELYDDFTPFDEADFYPTTSFYAEGDEEEEEELEEDEEEEEEDGGLEDENGYRPPASAAPRIPPPPSPTEGTPMARPRPGERVVPENSSECRSGYVRHNSSCRSVCDLVPSYCHNGGQCYLVESHGAFCRCNTQDYTWHKGTRCEAIVTDFQVLCVAVGSAALVLLLLFMLTVFFAKKLYLLKTENSKLRKTKYRTPSELHNDNFSLSTIAEGSHPNDDPGAPHKLQDPLKPGLKDEEPLSILSAAPEEGSKGEPGGCGVPCLHNNLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TEH6</accession>
    <name>A0A8C2TEH6_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Exocyst complex component 1-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">EXOC1L</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_032300440.1">
        <property type="nucleotide sequence ID" value="XM_032444549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TEH6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005018163.1">
        <property type="protein sequence ID" value="ENSCJPP00005012548.1"/>
        <property type="gene ID" value="ENSCJPG00005010674.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107313691"/>
    <dbReference type="KEGG" id="cjo:107313691"/>
    <dbReference type="CTD" id="644145"/>
    <dbReference type="GeneTree" id="ENSGT00940000162193"/>
    <dbReference type="OrthoDB" id="8734520at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.90:FF:000004">
        <property type="entry name" value="Exocyst complex component 1 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028258">
        <property type="entry name" value="Sec3-PIP2_bind"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16092:SF14">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 1 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16092">
        <property type="entry name" value="SEC3/SYNTAXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15277">
        <property type="entry name" value="Sec3-PIP2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01313">
        <property type="entry name" value="Sec3-PIP2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exocyst complex component Sec3 PIP2-binding N-terminal" evidence="2">
        <location>
            <begin position="30"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00072567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005012548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="170" mass="20056" checksum="EA4D7605F2715A6E" modified="2022-01-19" version="1">MSSLVKEDLTKRLFGPRRLRLHEFIEVEDSGAERCYLCAAVTKSEEVEICMVKHFRDREEKYEVVEKWFLKDLEMIDGKEADTDNPYFDMHFHKVYSMEAYSCASKYTFARTLSNLNEMYLKKDLKIVNFDSTYLNDDSIWSSNNRDCLVLMRICFYASNLLCLSLCPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TG60</accession>
    <name>A0A8C2TG60_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">hexokinase</fullName>
            <ecNumber evidence="4">2.7.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">HK3</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the phosphorylation of various hexoses to hexose 6-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>D-fructose + ATP = D-fructose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:16126"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-glucose + ATP = D-glucose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17825"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:17826"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>D-mannose + ATP = D-mannose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11028"/>
            <dbReference type="ChEBI" id="CHEBI:4208"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:11029"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a D-hexose + ATP = a D-hexose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22740"/>
            <dbReference type="ChEBI" id="CHEBI:4194"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:229467"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:22741"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the hexokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.1" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2TG60"/>
    <dbReference type="Ensembl" id="ENSCJPT00005019003.1">
        <property type="protein sequence ID" value="ENSCJPP00005013177.1"/>
        <property type="gene ID" value="ENSCJPG00005011139.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182787"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00242"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019158">
        <property type="term" value="F:mannokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.367.20:FF:000001">
        <property type="entry name" value="Hexokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000095">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.367.20:FF:000005">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019807">
        <property type="entry name" value="Hexokinase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF1">
        <property type="entry name" value="HEXOKINASE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00378">
        <property type="entry name" value="HEXOKINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="15">
        <location>
            <begin position="12"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="16">
        <location>
            <begin position="183"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase N-terminal" evidence="15">
        <location>
            <begin position="427"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="16">
        <location>
            <begin position="627"/>
            <end position="861"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00050361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00059457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005013177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="870" mass="94750" checksum="9A722D71FD8C784E" modified="2022-01-19" version="1">YPSENCPAGYVLEALERGMSQQGQAPSPMKMLPTFIRSTPDGTGETALLGASPGRERSAVVLGAEQGSLMHHIFEIPVNIPQGPGEALFDFIAQCLKTFLGEIGSPETRLPLGFVFPFSCRQMALDKAELISWSKGFQCSNVEGKDVVQLLQAAISRQEVVALMNNTVGAMMTCSTPQKPCEIALVVGSGTNCCFMAESRLLELADVTSGRMCVNSEWGCLGDDGALDNVLTPYDHRVDQESSNPGERRFEKLVGSVYLGEIVRHAIITLASEQALFVGKNTSALANRGMLTAQQVLGIMDNENGMAKAQDLLESLGLQPSEQDCCRVQQLCRAVVSRAAALSATGLAAVLSHMCYSRQQEQLMVNVGVDGGLYLTSTRFGEIMRSVVGLLAPECTVNLVPTTDGNGLGAAIVTAVALRLAAQQKKMQQLLGPLQLSHTDLQRVQALMMQEMERGLDKERNAESSLRMLPTYVCHTPDGTERGEFLALDLGGTNFRVLAVNVSQENIDMSSKIYAIPTAIMQGTGELFDHIMDCIIDFQHEKQMRGQALPLGFTFSFPCQQLGLDKAVLLNWTKGFNASDCEGRDVVQLLRDAAQRKRVGKALKVVAVVNDTVGTMMACGYHDPKCEIGLIVGTGTNTCYMEEMAKVGTVEGDQGRMCINMEWGAFGDNGCIDSYFTNFDRQVDEKTINVGKQRFEKLISGMYLGEIVRHILLALVEEEVLLRGKSSQKLKNRNLLQTKFLSTIEAPGLSLLQVQAILRDLDLDANYEDSVLVREVCQIVSRRAAHLCAAGMAAVVEKMRESRGLEQFTVTVGVDGTLYKMHPYFSQNLHKMLKDLAPRCNVTFMQSEDGSGKGAALVAAVHSRQSNQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2THG8</accession>
    <name>A0A8C2THG8_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Class E basic helix-loop-helix protein 22</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Class B basic helix-loop-helix protein 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BHLHE22</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2THG8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005019768.1">
        <property type="protein sequence ID" value="ENSCJPP00005013792.1"/>
        <property type="gene ID" value="ENSCJPG00005011601.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162962"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070888">
        <property type="term" value="F:E-box binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061564">
        <property type="term" value="P:axon development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007423">
        <property type="term" value="P:sensory organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18954">
        <property type="entry name" value="bHLH_TS_bHLHe22_bHLHb5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000026">
        <property type="entry name" value="Basic helix-loop-helix family, member e23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050359">
        <property type="entry name" value="bHLH_transcription_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19290">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19290:SF52">
        <property type="entry name" value="CLASS E BASIC HELIX-LOOP-HELIX PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="9">
        <location>
            <begin position="167"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="22"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="81"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005013792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="258" mass="26391" checksum="E1C3F22A33900E3E" modified="2022-01-19" version="1">MERALGLPAEEDLFHKSLAASAKRMESAFRSPPGLDLSHPRDRQPSPLACYEAPEPEALLQPGVGGDPLALPPGSVCVKYGESASRSSVAESSGGEQSPDDDSDGRCELLLRGAGGDPRDASPAAGGGGGGGGGPGGGGGGGLKAAEGGCSNGHGHGGSKKSKEQRSLRLNINARERRRMHDLNDALDGLRAVIPYAHSPSVRKLSKIATLLLAKNYILMQAQALEEMRRLVAYLNQGQAISAASLPSSAASSAAPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TIM1</accession>
    <name>A0A8C2TIM1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Nuclease EXOG, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Endonuclease G-like 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">EXOG</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Endo/exonuclease with nicking activity towards supercoiled DNA, a preference for single-stranded DNA and 5'-3' exonuclease activity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA/RNA non-specific endonuclease family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015708373.1">
        <property type="nucleotide sequence ID" value="XM_015852887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TIM1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005018702.1">
        <property type="protein sequence ID" value="ENSCJPP00005012981.1"/>
        <property type="gene ID" value="ENSCJPG00005010980.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107308774"/>
    <dbReference type="KEGG" id="cjo:107308774"/>
    <dbReference type="CTD" id="9941"/>
    <dbReference type="GeneTree" id="ENSGT00940000160677"/>
    <dbReference type="OrthoDB" id="5418055at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006309">
        <property type="term" value="P:apoptotic DNA fragmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00091">
        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.570.10:FF:000003">
        <property type="entry name" value="Nuclease EXOG, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.570.10">
        <property type="entry name" value="Extracellular Endonuclease, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044929">
        <property type="entry name" value="DNA/RNA_non-sp_Endonuclease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001604">
        <property type="entry name" value="Endo_G_ENPP1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020821">
        <property type="entry name" value="ENPP1-3/EXOG-like_nuc-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041003">
        <property type="entry name" value="Exog_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040255">
        <property type="entry name" value="Non-specific_endonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966">
        <property type="entry name" value="ENDONUCLEASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966:SF19">
        <property type="entry name" value="NUCLEASE EXOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01223">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18026">
        <property type="entry name" value="Exog_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00892">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00477">
        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="DNA/RNA non-specific endonuclease/pyrophosphatase/phosphodiesterase" evidence="20">
        <location>
            <begin position="90"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="ENPP1-3/EXOG-like endonuclease/phosphodiesterase" evidence="19">
        <location>
            <begin position="91"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="16">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00053281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00074243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00081050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR640255-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR640255-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005012981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="382" mass="43356" checksum="D2E03317BF8BF3EF" modified="2022-01-19" version="1">MAGRQRSLQRSTACLLPSIMAAVPRHRRFLGGFICGAAAGVTVSCWAAWRLLRSQSQAEPGSERALPEEPVEESLLEKYGFPEAGTETRCYTNHALSYDQAKRVPRWVIEHISKQKMLGNADRRHCKFRPDPNIPLMFSAVNEDYLGSGWSRGHMAPAGDNKFSTRAMAETFYLSNIVPQNYENNAGFWNRMEMYCRELTERFEDVWVVSGPLTLPQTSNDGKKSVTYQVIGKDDVAVPSHLYKVILARRTRTSTEPLALGAFVVPNDPIGFSHQLTEFQVKIEDLEKMSGLVFFPQVDKTKDVKDICEVDTCKLMGFKEFTLYIVTRKVQNARTLHRLEKAMSELKEAGIEPDEYLLKLHKKKEEELQQEKQTTAREGRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TJ95</accession>
    <name>A0A8C2TJ95_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NOC2 like nucleolar associated transcriptional repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">NOC2L</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOC2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015738178.1">
        <property type="nucleotide sequence ID" value="XM_015882692.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TJ95"/>
    <dbReference type="Ensembl" id="ENSCJPT00005019174.1">
        <property type="protein sequence ID" value="ENSCJPP00005013328.1"/>
        <property type="gene ID" value="ENSCJPG00005011262.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107323513"/>
    <dbReference type="KEGG" id="cjo:107323513"/>
    <dbReference type="CTD" id="26155"/>
    <dbReference type="GeneTree" id="ENSGT00390000010057"/>
    <dbReference type="OrthoDB" id="10266662at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030690">
        <property type="term" value="C:Noc1p-Noc2p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030691">
        <property type="term" value="C:Noc2p-Noc3p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140297">
        <property type="term" value="F:DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034644">
        <property type="term" value="P:cellular response to UV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002903">
        <property type="term" value="P:negative regulation of B cell apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001243">
        <property type="term" value="P:negative regulation of intrinsic apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045815">
        <property type="term" value="P:transcription initiation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005343">
        <property type="entry name" value="Noc2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12687">
        <property type="entry name" value="NUCLEOLAR COMPLEX 2 AND RAD4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12687:SF4">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03715">
        <property type="entry name" value="Noc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="87"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="656"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="107"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="657"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="693"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="752"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005013328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="766" mass="87753" checksum="38BA1D189EF3B8A7" modified="2022-01-19" version="1">MAAAGRRKLEELSVDEFLANGYESEPDSGLEEEEEAQPVAKGRRPKPKAAVRKKGKASEHKDQLSRLKEKDPEFYKFLEENDRTLLNFDASDSSEEEEGGLHVLPDTLEEASDEGEEDDDDEEREKVKQKKAESIPVNLKMVEEWKKAAARGLTPRLFHEITQAFKAAVATTKGDGGGADPSKFQVLDAAVFNALVSFCVRDLFGCLQKLLLVKAPKNKQKMALPSSSPLWSKLRLDVRMYLSCTIQLLSCLTEASVGAAVLQHVNSIVPYYLSFPKQCRMLLKQAIHLWSTGEETVRVLSFLVLNKICRHRKDVYLSPLLKQMYIAFVKNSRFTSPNVLPMINFMQRTLTEMYALDTHTSYQHAFIYIRQLAIHLRSAMTIKKKENFQSVYNWQYVHCLYFWCRVLSTIYPSEVMEPLIYPLTQVIIGCIKLVPTARFYPLRMHCIRALTLLSENTRTFIPVLPFILEIFQQVDFNKRPGRMSAKPINFAVILKLSNANLQEKAFRDGLIDQLYDLILEYLHSQAHSIGFPELVLPTVIQLKSFLKECKIANYCKPIRQLLEKLQENSAYISSRRQKTTFGVASRESVEQWEKQIKEEGTPLTKYYAQWKKLREKEIQLEITGKERLEDLNFPEIKRRKQDERKEEDKKEFKDLFELDTDSDEEDVGLSIKGKAKGKEESDDSSDASSKEDYGEDDEDEEGEYEVEEDEEDLEEGSDSDEEGKAAPRGSQRAKKSSPQALSRSDLEQLAQGEEDVVEDLAFSDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TK22</accession>
    <name>A0A8C2TK22_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">TLR4 interactor with leucine rich repeats</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">TRIL</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015709352.1">
        <property type="nucleotide sequence ID" value="XM_015853866.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TK22"/>
    <dbReference type="Ensembl" id="ENSCJPT00005021460.1">
        <property type="protein sequence ID" value="ENSCJPP00005015107.1"/>
        <property type="gene ID" value="ENSCJPG00005012555.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107309233"/>
    <dbReference type="KEGG" id="cjo:107309233"/>
    <dbReference type="CTD" id="9865"/>
    <dbReference type="GeneTree" id="ENSGT00940000161975"/>
    <dbReference type="OrthoDB" id="694479at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046696">
        <property type="term" value="C:lipopolysaccharide receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001530">
        <property type="term" value="F:lipopolysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002718">
        <property type="term" value="P:regulation of cytokine production involved in immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034142">
        <property type="term" value="P:toll-like receptor 4 signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000169">
        <property type="entry name" value="TLR4 interactor with leucine rich repeats"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000247">
        <property type="entry name" value="TLR4 interactor with leucine rich repeats"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050328">
        <property type="entry name" value="Dev_Immune_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373">
        <property type="entry name" value="SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373:SF307">
        <property type="entry name" value="TLR4 INTERACTOR WITH LEUCINE RICH REPEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0391">Immunity</keyword>
    <keyword evidence="12" id="KW-0395">Inflammatory response</keyword>
    <keyword evidence="3" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 16" id="KW-0732">Signal</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034099456" description="TLR4 interactor with leucine rich repeats" evidence="16">
        <location>
            <begin position="29"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="649"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="411"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="478"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="421"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="442"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="510"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00074774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="760" mass="82581" checksum="EFA25B73FDF06565" modified="2022-01-19" version="1">MGARRRLLLMVPWGSVALFLLLLPAAEPICPEPCDCQQHQHLLCTNRGLRSVPKTDEPQDVLTYSLGGNFITNISAFDFHRLSGLQRLDLQYNRIRSLHPKAFEHLGRLEELYLGNNLLPALAPGTLSTLAKLRILYVNANEIGRLSAASFSGLGSLVKLRLDGNELGSLGDSTFSGLPNLLYLHLESNRIRWLSRGAFTGLARLRFLDLSGNQQSSLRHPELFGPLRSLHTLLLASNSLQQLAGGLFRHLPTLAKLSLSDNRLAHLAPDAFMGLGSLKELRLEGNQLSHLPDALLEPLRSLEALDLSRNALTTLHPTTFGRLSHLRELSLRDNALTTLPGELFTSSPALFRLELEGNTWSCDCRLRGFKHWLGAWHSQGRLLTVFVQCHLPPNLAGKYLDYLQDNQLLPPPDGSPCLNGASPSASPLPAAEGLGTNSSSAVGPVGLPHGPLGVPPPSASTARLLAVPEDEMVAPQGMVESPSPTLLPARPKASGPVPPSVAWPRRGGKPRSVPSSSMPPLVSDPCDFNKLFLCNLSVEAVGSSSVTVRWAVRPHRSPRLLGPARFRLLFDRFGAAVKFQRFVYLPERGEPAATLRELRPDTPYLVCVEGVLGGRVCPVAPRDHCAGLVTLPEGSAVAAGGPRGPDQQLLTLVLLAVNALLLFAALAAWASRLLRKKVLGRRRRKAAPVHVRQLYSTRRPLRSMGTGVSADFSGFQSHRPPRGAACALSEADLIEFPCERFMDSGSARHGDDHLLQRFAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TKY4</accession>
    <name>A0A8C2TKY4_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Neuritin 1 like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">NRN1L</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the neuritin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TKY4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005020403.1">
        <property type="protein sequence ID" value="ENSCJPP00005014313.1"/>
        <property type="gene ID" value="ENSCJPG00005011955.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063853"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990138">
        <property type="term" value="P:neuron projection extension"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026144">
        <property type="entry name" value="Neuritin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15902:SF2">
        <property type="entry name" value="NEURITIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15902">
        <property type="entry name" value="NEURITIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15056">
        <property type="entry name" value="NRN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="96"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005014313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="133" mass="14331" checksum="FE8E1248C10246A3" modified="2022-01-19" version="1">QLMPEGFLPPLLWSPTAGKCNTIYKGFAGCLISLGDSMAQSVRSWDEFHACASGVLSRCPEEAAAIWESLRQESRKIQFQGNLQELCSTRGRLASAQGSPPAETNQATLRGSAPPRHPTILPLLALVLLGAWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TL00</accession>
    <name>A0A8C2TL00_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Germ cell-less 1, spermatosis associated</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">GMCL1</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus matrix</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015738431.1">
        <property type="nucleotide sequence ID" value="XM_015882945.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TL00"/>
    <dbReference type="Ensembl" id="ENSCJPT00005020025.1">
        <property type="protein sequence ID" value="ENSCJPP00005014003.1"/>
        <property type="gene ID" value="ENSCJPG00005011749.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005020026.1">
        <property type="protein sequence ID" value="ENSCJPP00005014004.1"/>
        <property type="gene ID" value="ENSCJPG00005011749.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107323649"/>
    <dbReference type="KEGG" id="cjo:107323649"/>
    <dbReference type="CTD" id="64395"/>
    <dbReference type="GeneTree" id="ENSGT00940000156185"/>
    <dbReference type="OrthoDB" id="6359943at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007281">
        <property type="term" value="P:germ cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18495">
        <property type="entry name" value="BACK_GCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18305">
        <property type="entry name" value="BTB_POZ_GCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000092">
        <property type="entry name" value="Germ cell-less, spermatogenesis associated 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043380">
        <property type="entry name" value="Gcl-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23231:SF17">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23231">
        <property type="entry name" value="GERM CELL-LESS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0221">Differentiation</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0744">Spermatogenesis</keyword>
    <feature type="domain" description="BTB" evidence="7">
        <location>
            <begin position="90"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="11"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005014004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="510" mass="57188" checksum="C067298FC1473605" modified="2022-01-19" version="1">MGSMGSRLLGRRGGTAVGDGAAGEGGERGGGGRGRRGGKRKRGGGEGPGDSESDSDSDRDEAANSAPRRKKLKSTSVYIYQTLFLNGENSDIKICALGEEWNLHKVYLRQSGYFSSMFSGSWKESCMDTIELEIPDQNIDIEALQVAFGSLYRDDVLIKPGRVVALLAAACMLQLDGLILQCGETMKETISAKTVCSYYSSAGTYGLDSVKKRCLEWLLNNLMTHQSVDLFKELSINLMKQLISSSNLFVMQVEMDLYTALKKWMFLQLVPSWNGPLKQLLAQADAWFAERRRELDGDAAFLDTEQGAAFRPVFSHLRLQYIISDLVSVRIVERDALIPPEWLLSVYKQQWFAMLRVEQDNDTGPQEINKEELEGSSMRCGRKLAQDGDYCWRWTGFNFGFDLLITYTNRYIIFKRNTLNQPCSGSVSLQPRRSIAFRLRLASFDSNGKIICSRTTGYQILSLEKDQEQVVMNLDSRLLVFPLYICCNFLYTSPEKRTGSTAGPEGTDQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TLF2</accession>
    <name>A0A8C2TLF2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Serine/threonine-protein kinase RIO2</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">RIO kinase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Serine/threonine-protein kinase rio2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">RIOK2</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16 25">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 25">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="17">Associated with late 40S pre-ribosomal particles. Interacts with PLK1 (via its N-terminus).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="RefSeq" id="XP_015704985.1">
        <property type="nucleotide sequence ID" value="XM_015849499.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TLF2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005020259.1">
        <property type="protein sequence ID" value="ENSCJPP00005014184.1"/>
        <property type="gene ID" value="ENSCJPG00005011868.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107306384"/>
    <dbReference type="KEGG" id="cjo:107306384"/>
    <dbReference type="CTD" id="55781"/>
    <dbReference type="GeneTree" id="ENSGT00390000003255"/>
    <dbReference type="OrthoDB" id="10258631at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome Z"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000208">
        <property type="term" value="P:positive regulation of ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000234">
        <property type="term" value="P:positive regulation of rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030071">
        <property type="term" value="P:regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd05144">
        <property type="entry name" value="RIO2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000053">
        <property type="entry name" value="Serine/threonine-protein kinase RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000307">
        <property type="entry name" value="Serine/threonine-protein kinase RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000052">
        <property type="entry name" value="Serine/threonine-protein kinase RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030484">
        <property type="entry name" value="Rio2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015285">
        <property type="entry name" value="RIO2_wHTH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018935">
        <property type="entry name" value="RIO_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45852">
        <property type="entry name" value="SER/THR-PROTEIN KINASE RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45852:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09202">
        <property type="entry name" value="Rio2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01245">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RIO kinase" evidence="22">
        <location>
            <begin position="66"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="348"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00064676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00068353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00068837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00076005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="SMART" id="SM00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005014184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="551" mass="63409" checksum="6367518EC7369B9B" modified="2022-01-19" version="1">MGKLNVVMLRYLTREHFRVLTAVEMGMKNHEIVPASLIASIASLKHGGCNKILRELAKHRLLAYERTKTVQGYRLTNAGYDYLALKTLSSRQVISSVGNQMGVGKESDIYIVANEDEQQFAMKLHRLGRTSFRSLKNKRDYHKHRHKMSWLYLSRLAAMKEFAYMKALYDRKFPVPKPVDYNRHAVIMELLDGYPLCQVHQVEDPASVYSELMDLIVKLANHGLIHGDFNEFNLILDNDDHVTMIDFPQMISTSHPNAEWYFDRDVTCIREFFKKRFNYESELFPEFKDIRRESSLDIEIAASGYTKEMQEDDELLHPSVSDEDDNTAEVSEFEEFAESNLRFFKSNQEDNAELIREEDSDSRTSEDAMYRNEEADATETSENLQKLSLSELSSALDEVEGQPVHCKSSEDAESCVTVFSEHERVLEGTSEDKATQGECCIDKDNEGDECPDLVDLSALNRKFKPFRNEDSMPHIAENKARTRTTSVSSLGSCSTIPPELVKKKIKRQLTKQQKSALRQRLQKGEANIYTKQRRENMHNIKSSLDAASFWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TM32</accession>
    <name>A0A8C2TM32_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Fused homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">STK36</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 18">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 18">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="RefSeq" id="XP_015724426.1">
        <property type="nucleotide sequence ID" value="XM_015868940.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005022421.1">
        <property type="protein sequence ID" value="ENSCJPP00005015869.1"/>
        <property type="gene ID" value="ENSCJPG00005013104.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107316911"/>
    <dbReference type="KEGG" id="cjo:107316911"/>
    <dbReference type="CTD" id="27148"/>
    <dbReference type="GeneTree" id="ENSGT00940000158375"/>
    <dbReference type="OrthoDB" id="266718at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001222">
        <property type="term" value="F:transcription corepressor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035082">
        <property type="term" value="P:axoneme assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003351">
        <property type="term" value="P:epithelial cilium movement involved in extracellular fluid movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045880">
        <property type="term" value="P:positive regulation of smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007224">
        <property type="term" value="P:smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd14002">
        <property type="entry name" value="STKc_STK36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000292">
        <property type="entry name" value="Serine/threonine-protein kinase 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22983">
        <property type="entry name" value="PROTEIN KINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22983:SF6">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="4"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="287"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="351"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="358"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00075375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1323" mass="145641" checksum="7DD2072663EC791D" modified="2022-01-19" version="1">MERYHVLEVIGEGSFGRVYKGRRRCSAQVVALKFIPKVGRSEKELKNLQREIEIMRGLRHPNIIQMLDSFETDKEVVMVTDYAEGELFQILEDDGSLPEDQVQIIAAQLVSALYYLHSHRILHRDMKPQNILLGKDGVIKLCDFGFARAMSIHTMVLTSIKGTPLYMSPELVEERPYDHTADLWSVGCILYELFTGKPPFYTSSIFQLVSLIVKDPVKWPKAISPTFKSFLQGLLMKDPRQRLSWPELLSHPFVAGRVTVIDDTEEHGISNPFTTKLSPELQALKEQQAHSLAPRSGQSRILRKARQKMAEEAQKKGQLKAKTPSMKDSGKGHTRHKPREAFGKAALEEGKELPASFQEKNSGVLQGKNSMSEWQLEEPPPSPREHSITQDYEREFPQPEAPLQLGVGRAELEGRQSIEAVDLESEELGSDEEWQHLIEATEPLAMQLSTPLSLLRDSAFRHRVQARLAESAQQVLEGMLEGASHLRSVLRVVGNLLATRCDSELLNLFCQELNVPLSLLHLAKQILESGRTKQQPWCIAVLTDLIMVTTGYFSSERSLEKSGQDSLQTFQESANYFLSLLPDLLAEPADSEMRLCQQSLLCFTLLCESLDAMCSSISVPFYASLREENEPLLDRLLQGLISEQPALQGAAMEAKSAHDQRQCVADLCTAVLAAACSIPPTQSSCWKAKQQVAQEIAGKLMDGESHQLGKLLGRLEHPNCSLNVLKILYTGCYASPNLCQHLGRSQQVFDFLMQLSKSKVPMAEVTQRVACEGSLCLLALLTLQPQVSPSRLEEVVTLARDLLTQSPVISVVGAAAFILTQLDQRGVPVALEGKEILPAVTNAMMEPAELHFSLPMGAGLYDGIIFLLLKLLAQEDATVEQSFAASELWSVVWHCVSAVLCMGGGAALEGNSPGAEPDWSLLSPQGTLLFLSLALFIFTRETHRCLPHLTQSHGVFMVMLKTLLSPRFLACLAMTQAGENGEAELIPAVVIQACQLLCFPFALDVDGNTIALVIEAVRDSQIPLQLLQVCCHHLPFSDTELPMSLLCRLVVSDEQVTDQVAREAAASEHIIAYLSTVLFSGSLTLTTDLLSLLTHVARTCPEHLPFLQRILGGSDMSYQALTHLLSHKEHPIRAKTCYLLGNLFRHSFPQVLQNQPGLLESLLLCLADEDDAVRKAASFAVGNAAYHESSPAGTLGRAVPRLTQLLRDHQAKTRCNAASALGNLGRRSAGLGELLIESRAPHILLEVACRDPQARVREGALMALRAVSQHPGIQQVLQSLGAGDQLAALANSNSWPVAGGSPRPSSARHCQKLIRLLTPLQST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TM84</accession>
    <name>A0A8C2TM84_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transcription factor CP2 like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">TFCP2L1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the grh/CP2 family. CP2 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TM84"/>
    <dbReference type="Ensembl" id="ENSCJPT00005022146.1">
        <property type="protein sequence ID" value="ENSCJPP00005015650.1"/>
        <property type="gene ID" value="ENSCJPG00005012935.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159158"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007028">
        <property type="term" value="P:cytoplasm organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008340">
        <property type="term" value="P:determination of adult lifespan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002070">
        <property type="term" value="P:epithelial cell maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045927">
        <property type="term" value="P:positive regulation of growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007431">
        <property type="term" value="P:salivary gland development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd09590">
        <property type="entry name" value="SAM_LBP9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000022">
        <property type="entry name" value="Transcription factor CP2 like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007604">
        <property type="entry name" value="CP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057520">
        <property type="entry name" value="GRHL1/CP2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041418">
        <property type="entry name" value="SAM_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040167">
        <property type="entry name" value="TF_CP2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037598">
        <property type="entry name" value="TFCP2L1_SAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11037">
        <property type="entry name" value="TRANSCRIPTION FACTOR CP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11037:SF18">
        <property type="entry name" value="TRANSCRIPTION FACTOR CP2-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04516">
        <property type="entry name" value="CP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25416">
        <property type="entry name" value="GRHL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18016">
        <property type="entry name" value="SAM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51968">
        <property type="entry name" value="GRH_CP2_DB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Grh/CP2 DB" evidence="9">
        <location>
            <begin position="161"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="337"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="386"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="339"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="386"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="400"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="646" mass="73307" checksum="4A7FEA43E19B02DD" modified="2022-01-19" version="1">MLDSKLRKDVSHPVPQTPSRGTQPHIAPPHPHGATCAPRLLCGAGRGRSRCSAAQPTRARRGWAIKAPGAVGAATGAVGRRRQRCPVRLGVGSPAGTLLVTPPSDRAGLPPSHPRRAKMLFWHTQPEHYNQHSTGSYLRDVLALPIFKQEEPQLSPENEAKLPPFQYVLCTATSPAVKLHEETLTYLNQGQSYEIRLLENRKLGEFQDLNTKYVKSIIRVVFHDRRLQYTEHQQLEGWRWSRPGDRILDIDIPLSVGILDPRASPTQLNTVEFLWDPSKRASAFIQVHCISTEFTPRKHGGEKGVPFRVQIDTFKQNENGEYTEHLHSASCQIKVFKPKGADRKQKTDREKMEKKTTQEKEKYQPSYETTILTECSPWPDLPYQMNSAPSPSYNSSPNSFNLGDGNSSPTHQVELLPPSNDHLLPSASIQDAQQWLHRNRFSPFCRLFSSFSGADLLKMSKEDFVQICGPADGIRLFNAIKGRNVRPKMTIYVCQEPEQNRSHLHQKRENGDGSLCVYHAIFLEELTTLELMEKIANLYSISPQQINRIYRQGPTGIHVLVSNEMVQNFQDESCFVISTLKGNYWCSYYVFLKVFSLFSATKLFHKLGAGVLKRKLMLFLKVVKKLHLFTDRLLCVFLCYTAIRFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TNU2</accession>
    <name>A0A8C2TNU2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">P-type phospholipid transporter</fullName>
            <ecNumber evidence="2">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">ABCA1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 18">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005021563.1">
        <property type="protein sequence ID" value="ENSCJPP00005015180.1"/>
        <property type="gene ID" value="ENSCJPG00005012486.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154658"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome Z"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045335">
        <property type="term" value="C:phagocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034186">
        <property type="term" value="F:apolipoprotein A-I binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034188">
        <property type="term" value="F:apolipoprotein A-I receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120020">
        <property type="term" value="F:cholesterol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031210">
        <property type="term" value="F:phosphatidylcholine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="F:phosphatidylcholine floppase activity"/>
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        <property type="term" value="F:phosphatidylserine floppase activity"/>
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        <property type="term" value="F:protein transmembrane transporter activity"/>
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        <property type="term" value="F:signaling receptor binding"/>
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        <property type="term" value="F:small GTPase binding"/>
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        <property type="term" value="F:sphingolipid floppase activity"/>
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        <property type="term" value="F:syntaxin binding"/>
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        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0071222">
        <property type="term" value="P:cellular response to lipopolysaccharide"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0071300">
        <property type="term" value="P:cellular response to retinoic acid"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0033344">
        <property type="term" value="P:cholesterol efflux"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:cholesterol homeostasis"/>
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        <property type="term" value="P:cholesterol metabolic process"/>
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    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:export across plasma membrane"/>
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    <dbReference type="GO" id="GO:0034380">
        <property type="term" value="P:high-density lipoprotein particle assembly"/>
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    <dbReference type="GO" id="GO:0032367">
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        <property type="term" value="P:lipoprotein biosynthetic process"/>
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        <property type="term" value="P:lysosome organization"/>
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    <dbReference type="GO" id="GO:0002790">
        <property type="term" value="P:peptide secretion"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006911">
        <property type="term" value="P:phagocytosis, engulfment"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:phospholipid efflux"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0055091">
        <property type="term" value="P:phospholipid homeostasis"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0060155">
        <property type="term" value="P:platelet dense granule organization"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010875">
        <property type="term" value="P:positive regulation of cholesterol efflux"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0090108">
        <property type="term" value="P:positive regulation of high-density lipoprotein particle assembly"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0032489">
        <property type="term" value="P:regulation of Cdc42 protein signal transduction"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0034616">
        <property type="term" value="P:response to laminar fluid shear stress"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:reverse cholesterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:signal release"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd03263">
        <property type="entry name" value="ABC_subfamily_A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000232">
        <property type="entry name" value="ATP-binding cassette, sub-family A (ABC1), member 1"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.40.50.300:FF:000264">
        <property type="entry name" value="ATP-binding cassette, sub-family A (ABC1), member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056264">
        <property type="entry name" value="R2_ABCA1-4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF34">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE ABCA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12698">
        <property type="entry name" value="ABC2_membrane_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23321">
        <property type="entry name" value="R1_ABCA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="647"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="685"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="721"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="750"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="782"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1353"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1660"/>
            <end position="1682"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1702"/>
            <end position="1728"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1740"/>
            <end position="1759"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1771"/>
            <end position="1795"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1858"/>
            <end position="1880"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="906"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="1917"/>
            <end position="2149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1291"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1293"/>
            <end position="1305"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012189"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
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            <dbReference type="ARBA" id="ARBA00022967"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
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    <evidence type="ECO:0000256" key="9">
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            <dbReference type="ARBA" id="ARBA00023136"/>
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            <dbReference type="ARBA" id="ARBA00023157"/>
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            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="2266" mass="254575" checksum="AEAFEE767B4AA9D0" modified="2022-01-19" version="1">RRNGLYWKLCSVLYFGYDILILCVCCFQFQLLIEVAWPLFIFFILISVRLSYPPYEQHECHFPNKAMPSAGTLPWIQGIICNANNPCFRYPTPGESPGIVGNFNASIVSRLFSDAKRLLLYSQQDTSIKDVQKVLAKLRKLGNSSDLKLRDFLVDNETFSDFLSHNASMPSSAVEELLDAEVNLQKVIVSGYQMQLQDLCNSSVLSEFLTIQNRSVAMDSEAFLCTLPKETLHGAELAFRANLNPLKPLQRQFFFNSSLRDLSETVETLRDSLGKLIKELLSMKSWSDMRQEVMFLTNVNASNSSTQIYQAVSRIVCGHPEGGGLKIKSLNWYEDNNYKALFGGNSTEDDVTNFYDNSTTPYCNELMKNLESSPLSRIIWKALKPLLIGKVLYTPDTPAIRKIMAEVNRTFQELGVFRDLGGMWEEISPKIWTFMESSQEMDLIRTLLKSKAFWDMHLPASNWTVEDVARFLSKHPEESETDNGMVYTWVDAFNETDRAIQTISRFMECVNLDKLEPVATEVRLINKSLELLDERRFWAGVVFTEIAPNSTELPQHVKYKIRMDIDNVERTNKIKDGYWDPGPRADPFEDMRYVWGGFTYLQDVVEQAIIRVQTGTEKKTGVYVQQMPYPCYVDDIFLRVMSRSMPLFMTLAWIYSVAVIIKGIVYEKEARLKETMRIMGLDNGILWLSWFISSLIPLLMSAGLLVLILKMGNLLPYSDPSVVFVFLSIFGIVTILQCFLISTVFSRANLAAACGGIVYFTLYLPYVLCVAWQDYVSFSLKIFASLLSPVAFGFGCEYFALFEEQGVGVQWDNFFESPLEEDGFSITTSAVMMLFDTFLYGVMTWYIESVFPGQYGIPRPWYFPFTKSYWFGEESQDRHPSYSLLLFSVFLSVCKEEEPMHLSLGVSIQNLVKVYRDGKKVAVDGLTLNFYEGQITSFLGHNGAGKTTTMSILTGLFPPTSGTAFILGKDIRSELSTIRQNLGVCPQHNVLFDLLTVEEHIWFYARLKGLPEKKVKEEMEQMAMDVGLPHKLKARTSKLSGGMQRKLSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELLLKYRQGRTIILSTHHMDEADILGDRIAIISHGKLCCVGSSLFLKNQLGTGYYLTLVKKDVDSSLSSCRNSSSTVSYLKKDDSVSQSSSDAGLGSDHESDTLTIDVSAISNLITKHVPEARLVEDIGHELTYVLPYKAAKEGAFVELFHEIDDRLSDLGISSYGISETTLEEIFLKVADDSGVDAETSDGTLPARRNRRAFGDRQSCLRPFTEDDAFDPNDSDIDPESRETDLLSGMDGKGSYQMKGWKLSQQQFVALLWKRLLIAKRSRKGFFAQIVLPAVFVCIALMFSLIVPPFGKYPSLELQPWMYNEQYTFISNDAPEDAGTQKLLDALLNKPGFGTRCMQGHSIPDTPCTVGQKEWTTASVPDSVLEILRGNWSMENPSPSCECSNEKIKKMLPVCPPGAGGLPPPQREQDTADILQNLTGRNISDYLVKTYAQIIGKSLKNKIWVNEFRYGGFSLGARSSHVLPPSNEVSDAIKQVKRILELAQGSSGDRFLNSLASFMKGLDTKNNVKVWFNNKGWHAIASFLNVINNAILRANLQQGKNPSAYGITAFNHPLNLTKQQLSEVALMTTSVDVLVSICVIFAMSFVPASFVVFLIQERVSKAKHLQFVSGVKPVIYWLANFVWDMCNYIVPATLVIIIFICFQQKSYVSSSNLPVLALLLLLYGWSITPLMYPASFVFKIPSTAYVVLTSVNLFIGINGSVATFVLELFTNNKLNNINDILKSVFLIFPHFCLGRGLIDMVKNQAMADALERFGENRFVSPLSWDLVGRNLFAMAVEGVVFFLITVLIQYRFFIKPRPVYAKLPPVNDEDEDVNRERQRIISGGGQSDILEIKELTKIYRMKRKPAVDRICVGIPPGECFGLLGVNGAGKSSTFKMLTGDTDVTGGEAFLKGNSILSNIQEVHQNMGYCPQFDAVNELLTGREHLEFFALLRGVPEKEVCKVGEWAIRKLGLVKYGEKYAGNYSGGNRRKLSTAIALIGGPPVVFLDEPTTGMDPKARRFLWNCALSVIKEGRSVVLTSHSMEECEALCTRMAIMVNGRFRCLGSVQHLKNRFGDGYTIVVRIAGGNPDLKPVEEFFGHAFPGSVLKEKHRNMLQYQLPSSQSSLARIFSVLSQNKKRLHIEDYSVSQTTLDQVFVNFAKDQSDDDHTKDLSLHKNQTVVDIAILNSFLQDEKVKESCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TPN9</accession>
    <name>A0A8C2TPN9_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Coronin 6</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat coronin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TPN9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005022477.1">
        <property type="protein sequence ID" value="ENSCJPP00005015921.1"/>
        <property type="gene ID" value="ENSCJPG00005013135.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159031"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015505">
        <property type="entry name" value="Coronin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856:SF24">
        <property type="entry name" value="CORONIN-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16300">
        <property type="entry name" value="WD40_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01167">
        <property type="entry name" value="DUF1900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="152"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="159"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="202" mass="22009" checksum="E471196363AB9AC1" modified="2022-01-19" version="1">MGLQELDSSNGALLPFYDPDTNVVYVCGKGDSSIRYFEITDESPYVHYLNTFSSKEPQRGMGFMPKRGLDVSKCEIARFFKLHERKCEPIIMTVPRKSDLFQDDLYPDTAGPEAALEAEEWVAGQTAGPLLVSLRQAYVPSKQRELKVNRHSLLHDGRSTATSPASSTPNPAGTGSTGSSRLSAPPALGTGTVNDERVLDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TPT4</accession>
    <name>A0A8C2TPT4_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">small monomeric GTPase</fullName>
            <ecNumber evidence="2">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC107314270</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2TPT4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005023410.1">
        <property type="protein sequence ID" value="ENSCJPP00005016696.1"/>
        <property type="gene ID" value="ENSCJPG00005013697.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000164949"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051065">
        <property type="entry name" value="Ras-related_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45704">
        <property type="entry name" value="RAS-LIKE FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005016696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="203" mass="23016" checksum="312331374BBF0C63" modified="2022-01-19" version="1">MSFPRPLRRSISLSPARTLRLVVLGQGAVGKTEMIYRHMAVIDGEMVHFEILDTAGQEDSLQIEEKIKWGDGFAVVYSVTDRCSFDEVMRLCFLINHIHSSPKRSGGSEQPPVVIVANKKDLQFDRMVSTQDGENLSKALKLPFYEISTRDSYEETVTVFSTLYQELMRQGHFSPGSFKRRTVSKVMEKIPKMQAISNKGCSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TQY6</accession>
    <name>A0A8C2TQY6_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mothers against decapentaplegic homolog</fullName>
            <shortName evidence="7">MAD homolog</shortName>
            <shortName evidence="7">Mothers against DPP homolog</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">SMAD family member</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC107324492</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the dwarfin/SMAD family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015740044.1">
        <property type="nucleotide sequence ID" value="XM_015884558.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TQY6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005024197.1">
        <property type="protein sequence ID" value="ENSCJPP00005017346.1"/>
        <property type="gene ID" value="ENSCJPG00005014182.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107324492"/>
    <dbReference type="KEGG" id="cjo:107324492"/>
    <dbReference type="GeneTree" id="ENSGT00940000158146"/>
    <dbReference type="OrthoDB" id="5946219at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071144">
        <property type="term" value="C:heteromeric SMAD protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070411">
        <property type="term" value="F:I-SMAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140416">
        <property type="term" value="F:transcription regulator inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060395">
        <property type="term" value="P:SMAD protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10489">
        <property type="entry name" value="MH1_SMAD_6_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.10:FF:000004">
        <property type="entry name" value="Mothers against decapentaplegic homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.520.10">
        <property type="entry name" value="SMAD MH1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013790">
        <property type="entry name" value="Dwarfin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003619">
        <property type="entry name" value="MAD_homology1_Dwarfin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013019">
        <property type="entry name" value="MAD_homology_MH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017855">
        <property type="entry name" value="SMAD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001132">
        <property type="entry name" value="SMAD_dom_Dwarfin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036578">
        <property type="entry name" value="SMAD_MH1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13703:SF67">
        <property type="entry name" value="MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13703">
        <property type="entry name" value="SMAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03165">
        <property type="entry name" value="MH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03166">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00523">
        <property type="entry name" value="DWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00524">
        <property type="entry name" value="DWB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56366">
        <property type="entry name" value="SMAD MH1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51075">
        <property type="entry name" value="MH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51076">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MH1" evidence="8">
        <location>
            <begin position="8"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="MH2" evidence="9">
        <location>
            <begin position="178"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005017346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="343" mass="38207" checksum="225317D452A06DA2" modified="2022-01-19" version="1">MFRSRRAALLRRLWRQRCATPGPEEGPGALKPAAHALFKKLKDEELELLLQAVESRGAWESGCVWVPRGAKQALPPQVLLCRLFRWPDLRQPHELKHLCYCQSAGGRGGCGDAAALCCNPYHFSRLAAPETPPPPYSKSISPSWPTEPKSPQLLEFNCNHTEWRDTSLSRSSSRDGCWCKLAYWEHRTRVGRLYSVHEASINVFNELPRGNGFCLGQLPAVHRSRAVRRARGKIGRGLLLSRELGAVWAYNRSEHPIFVSSPTLGPPGAHGLAVLKVLPGYSVKVFDYERVGGMGVLGWQNGDGPCDPHSVRISFGKGWGPCYSRQFITSCPCWLEVLLAQPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TSU1</accession>
    <name>A0A8C2TSU1_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TSU1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005024897.1">
        <property type="protein sequence ID" value="ENSCJPP00005017908.1"/>
        <property type="gene ID" value="ENSCJPG00005014552.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01140000282757"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005017908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="326" mass="34995" checksum="03D162DE64BE4552" modified="2022-01-19" version="1">QWAPPSELREVEVVGQEVALMGQEIELLGQEMALVGRKVELMGQEVELVGLEVALVGQEELALVGQDVALVCQEEEVVWREVGLVGPEVEVMWREVALVEQEMEVAGQELALVGQEMELLGQEVELVGQDVAHGQELALVWRDVEVVGREVALVGQEVALVGQEVEVVGQEVALVGQEVAVVGRELALVKHELALVGQEVELVGQEVALVGQEVALVGQEMEVVGREVALVGQEVAHLGEKVEHEVALLRQEVEVVGQEVELEGQEVEVVRQDMANVGEEVALVGLDVEVVGQELALVGQELALVGQEVALVALVGQEVEIVGLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TTW9</accession>
    <name>A0A8C2TTW9_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FA core complex associated protein 24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FAAP24</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015729445.1">
        <property type="nucleotide sequence ID" value="XM_015873959.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TTW9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005024707.1">
        <property type="protein sequence ID" value="ENSCJPP00005017735.1"/>
        <property type="gene ID" value="ENSCJPG00005014445.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107319259"/>
    <dbReference type="KEGG" id="cjo:107319259"/>
    <dbReference type="CTD" id="91442"/>
    <dbReference type="GeneTree" id="ENSGT00390000009456"/>
    <dbReference type="OrthoDB" id="5975714at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071821">
        <property type="term" value="C:FANCM-MHF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043240">
        <property type="term" value="C:Fanconi anaemia nuclear complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd20076">
        <property type="entry name" value="XPF_nuclease_FAAP24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10130:FF:000006">
        <property type="entry name" value="Fanconi anemia core complex-associated protein 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041663">
        <property type="entry name" value="DisA/LigA_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026985">
        <property type="entry name" value="FAAP24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040646">
        <property type="entry name" value="PND"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31786">
        <property type="entry name" value="FANCONI ANEMIA CORE COMPLEX-ASSOCIATED PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31786:SF2">
        <property type="entry name" value="FANCONI ANEMIA CORE COMPLEX-ASSOCIATED PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12826">
        <property type="entry name" value="HHH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17949">
        <property type="entry name" value="PND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="2" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fanconi anemia core complex-associated protein 24 pseudonuclease" evidence="4">
        <location>
            <begin position="15"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="DisA/LigA helix-hairpin-helix motif" evidence="3">
        <location>
            <begin position="168"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005017735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="215" mass="23637" checksum="41664C4B40E681AB" modified="2022-01-19" version="1">MAAKGNVPAAPGSVIVPYGHVVGNEKWRGSELARRLQGKTKLIFEDGLGLVDFHLSNRICVLYISEADLVAGDEFKRRLVRFRNASSLGGIVIVEKTPLSEQYFSAVQKLVVLQLGMVLLPVANQEEASQLITQIVREQSKDHTSNPFIRKQCSQLVEASMFRTVQQIPGVGKTKALLLLQQFGSIHQICNASVKELEPVVGQTVAQQIHTFFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TUQ5</accession>
    <name>A0A8C2TUQ5_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ITPRIP like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ITPRIPL2</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ITPRIP family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the mab-21 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015732575.1">
        <property type="nucleotide sequence ID" value="XM_015877089.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TUQ5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005026318.1">
        <property type="protein sequence ID" value="ENSCJPP00005018968.1"/>
        <property type="gene ID" value="ENSCJPG00005015423.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107320848"/>
    <dbReference type="KEGG" id="cjo:107320848"/>
    <dbReference type="CTD" id="162073"/>
    <dbReference type="GeneTree" id="ENSGT01050000244827"/>
    <dbReference type="OrthoDB" id="8745755at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026250">
        <property type="entry name" value="ITPRIP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046903">
        <property type="entry name" value="Mab-21-like_nuc_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046906">
        <property type="entry name" value="Mab-21_HhH/H2TH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024810">
        <property type="entry name" value="MAB21L/cGLR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10656">
        <property type="entry name" value="CELL FATE DETERMINING PROTEIN MAB21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10656:SF9">
        <property type="entry name" value="INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR-INTERACTING PROTEIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03281">
        <property type="entry name" value="Mab-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20266">
        <property type="entry name" value="Mab-21_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02107">
        <property type="entry name" value="INOS145TPRIP"/>
    </dbReference>
    <dbReference type="SMART" id="SM01265">
        <property type="entry name" value="Mab-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034544571" evidence="8">
        <location>
            <begin position="28"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Mab-21-like nucleotidyltransferase" evidence="9">
        <location>
            <begin position="150"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Mab-21-like HhH/H2TH-like" evidence="10">
        <location>
            <begin position="334"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF20266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005018968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="493" mass="53751" checksum="A3A5F6A26DBE357B" modified="2022-01-19" version="1">MAARVPEPRASWALLTVCTALLCLCQALGGRAAAAAEGEEEEGAAEAGSVPLLKGSALLLLGCLLARCCGSAGGGPRPGGGWGPAAARRGALEGFHARRLRLSPHVLGHSKAHVGRVVAELVRAAKAQGLQPGPAALSLRGDFVRVGSAYEQHKVRSPDRFDVLVPLRLPPRLQPEPRRAATSGAFVCGLRAPAGSGWPRRYRPFVEGFCAEPHGRQLLSSALVLRWFQGHLQRCLGAVRYRLQERCRISLAVCPGRPPTLHIRPCSDYVCCHISMAVRLIPAIPLGDALYLTVPPHDVPGAGPAHEALWGLDTSRHEQRLLAWLKEQAPASSCHLKCLQLLKGLRDLGGQRLEEPFCSLWGRVLSSYVLKTALFSLMLHGPLEAWDEQFLVERLEDLVMYLRDCLRKQTLMHFFMGNTSLPEAVALPRFLKEAAPVNLLSAFDGATLDLVAFQLLYTWSQAPHLIRTYSRARILQPAACRHGTETRHELPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TW05</accession>
    <name>A0A8C2TW05_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Atypical chemokine receptor 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Duffy antigen/chemokine receptor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">ACKR1</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Early endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Recycling endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the G-protein coupled receptor 1 family. Atypical chemokine receptor subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TW05"/>
    <dbReference type="Ensembl" id="ENSCJPT00005025910.1">
        <property type="protein sequence ID" value="ENSCJPP00005018647.1"/>
        <property type="gene ID" value="ENSCJPG00005015175.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000006372"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019956">
        <property type="term" value="F:chemokine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070098">
        <property type="term" value="P:chemokine-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005384">
        <property type="entry name" value="Duffy_chemokine_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14181:SF1">
        <property type="entry name" value="ATYPICAL CHEMOKINE RECEPTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14181">
        <property type="entry name" value="DUFFY ANTIGEN/CHEMOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01559">
        <property type="entry name" value="DUFFYANTIGEN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0967">Endosome</keyword>
    <keyword evidence="9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0807">Transducer</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="108"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="250"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="287"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005018647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="343" mass="36751" checksum="FFCCFA4692EC9337" modified="2022-01-19" version="1">APHCWHPAELCSSPGIIGNRTSLLLLDYNYSDYVDYMDNNTDINQDMGINQEDFAAAAPCHNRYCPFFHRAAPPYLIATSVTSLMATAALLLALSLRPKAWPRGRMLVAQLAACCGLFAITLLPMAAGIAWGWQMGEGPCKVALLLWHGSVLAQGLLLGVGCCNVWAHGWCLAVVLWVTAMGMAVPAALSGGIMGTGLSTQCVHRNVDVDSVVHLLQLTVYCCILLLLPGALLMTAVLRGMWGAMGQKVGWMFWVLWAPHGVVMVVEVLLEVGVIPTSCGAFESFDFALGLSAALGGLHCCLMPLMLLLTAFYGHKTPCPPPWGWGKEPRSPGTSMGCSPQPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TXM5</accession>
    <name>A0A8C2TXM5_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">INSM transcriptional repressor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">INSM1</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the INSM1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015712175.1">
        <property type="nucleotide sequence ID" value="XM_015856689.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TXM5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005026615.1">
        <property type="protein sequence ID" value="ENSCJPP00005019185.1"/>
        <property type="gene ID" value="ENSCJPG00005015593.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107310751"/>
    <dbReference type="KEGG" id="cjo:107310751"/>
    <dbReference type="CTD" id="3642"/>
    <dbReference type="GeneTree" id="ENSGT00940000162552"/>
    <dbReference type="OrthoDB" id="8953942at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017053">
        <property type="term" value="C:transcription repressor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042826">
        <property type="term" value="F:histone deacetylase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061104">
        <property type="term" value="P:adrenal chromaffin cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008283">
        <property type="term" value="P:cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003358">
        <property type="term" value="P:noradrenergic neuron development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042421">
        <property type="term" value="P:norepinephrine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003310">
        <property type="term" value="P:pancreatic A cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045597">
        <property type="term" value="P:positive regulation of cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000179">
        <property type="term" value="P:positive regulation of neural precursor cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010564">
        <property type="term" value="P:regulation of cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043254">
        <property type="term" value="P:regulation of protein-containing complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061549">
        <property type="term" value="P:sympathetic ganglion development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060290">
        <property type="term" value="P:transdifferentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003323">
        <property type="term" value="P:type B pancreatic cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001329">
        <property type="entry name" value="INSM transcriptional repressor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042972">
        <property type="entry name" value="INSM1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15065">
        <property type="entry name" value="INSULINOMA-ASSOCIATED 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15065:SF5">
        <property type="entry name" value="INSULINOMA-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6" id="KW-0221">Differentiation</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="257"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="363"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="391"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="144"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="276"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="152"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="298"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005019185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="432" mass="46045" checksum="8B43CD7F0E284E7C" modified="2022-01-19" version="1">MAPSLLKAAAASGRRREGGRERRSPPGADRPPARPKMPRGFLVKRSRRPTPVSYRVRVPPPAAPPPPPPPPPPPPPPPPPVPFGTPDGPVQALRSPTRPVSRDALLERGFSLGSPVSAESFPAPAVPSSMDPLLLGPAELKLWAARPPPNPNGGGGGGGGGGGSSAPAAKRPAEPGRQKAAAGKKAKAIRKLTFEDEVTTSPVLGLRIKEGPVEAPARRGGCARPLGEFICQLCKEEYGDPLALAQHRCSRIVRVEYRCPECHKIFSCPANLASHRRWHKPRPPAKSGPEPAEPPKEPTAAAAERDTPSPGGASEAGSEEGLFECPRCARRFRRQAYLRKHLLGHPAAPGPAPEPAAEPAEPRPCPVCGESFPSKSSQERHLRLLHAAQLFPCKYCPATFYSSPGLTRHINKCHPSENRQVVLLQVPLRPHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TYI3</accession>
    <name>A0A8C2TYI3_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TYI3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005028448.1">
        <property type="protein sequence ID" value="ENSCJPP00005020624.1"/>
        <property type="gene ID" value="ENSCJPG00005016582.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161421"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005020624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="154" mass="16183" checksum="48A3329D38589E0F" modified="2022-01-19" version="1">SRAFPLCALSPPDTAWNVSLSARGLQLRLHLTSHVPASFSAALCQRRAGRCEPEAPVYTVTRSSAPGELALLLPVQVLGSCVLVWRSDVRFARKQLLCPDGERSPRAGGDGAGCRGCLLTVPLPVSHRHFGLLGPRWAPSCTSPPTAAHAAAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TYU2</accession>
    <name>A0A8C2TYU2_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">G protein-coupled receptor 162</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">GPR162</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015728325.1">
        <property type="nucleotide sequence ID" value="XM_015872839.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015728336.1">
        <property type="nucleotide sequence ID" value="XM_015872850.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032302911.1">
        <property type="nucleotide sequence ID" value="XM_032447020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TYU2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005028745.1">
        <property type="protein sequence ID" value="ENSCJPP00005020884.1"/>
        <property type="gene ID" value="ENSCJPG00005016752.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107318693"/>
    <dbReference type="KEGG" id="cjo:107318693"/>
    <dbReference type="CTD" id="27239"/>
    <dbReference type="GeneTree" id="ENSGT00390000017213"/>
    <dbReference type="OrthoDB" id="9887972at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15906">
        <property type="entry name" value="7tmA_GPR162"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022347">
        <property type="entry name" value="GCR_153/162"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022348">
        <property type="entry name" value="GPR162"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16518">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 153, 162"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16518:SF6">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 162-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01991">
        <property type="entry name" value="GPR153GPR162"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01993">
        <property type="entry name" value="GPR162"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="27"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="545"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="545"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005020884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="568" mass="64222" checksum="8FCA6411ACEBE455" modified="2022-01-19" version="1">MGDSESESTLHNNSLWWLACGMLALLANSWIILSITAKQQKHKPLELLLCFLAGTHILMAAVPLTTYAVVQLRRESSNYDWNESICKVFVSTYYTLALATCFTVASLSYHRMWMVRWPVNYRLSNAKKQALHAVMGIWMVSFILSTLPSIGWHNNGERYYARGCQFIVSKIGLGFGVCFSLLLLGGIVMGLVCVGITFYQTLWAHRRRRQCCHQRPEEASSCSSAHNTFNVPAIVVEDVRGKRRSSLDGSESAKTSLQMTNLISAIVFLYDTLTGVPILVVSFFSLRYDTAPTWMVLAVLWCSMVQTLLLPSFIWSCERYRADLRTIWEQCVAIMSEEDGDDDGVCDDYGDGRICKVRFDANGAAAVKRDSRDIKLLPMHHMLLPQDKVHYLQVPISRRMSHDETNIFSAHRSAPSFLHKWSSSDDIRISTLRKPGGPGFLPPQLHDYQHRRQLPEDELTSLRQFLEGGLVPRGSSSSACFFRDEITTFIDETPQPTPVCSPRHSRLPLAACRDRRLSLGSREEESTDRPRWCSLAGSEAWRLQDEGQAPRDRTPEACEAQALQDPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TZC9</accession>
    <name>A0A8C2TZC9_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerase II subunit RPB4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">DNA-directed RNA polymerase II subunit D</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">DNA-directed RNA polymerase II subunit rpb4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">POLR2D</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. POLR2D/RPB4 is part of a subcomplex with POLR2G/RPB7 that binds to a pocket formed by POLR2A/RPB1, POLR2B/RPB2 and POLR2F/RPABC2 at the base of the clamp element. The POLR2D/RPB4-POLR2G/RPB7 subcomplex seems to lock the clamp via POLR2G/RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site cleft. The POLR2D/RPB4-POLR2G/RPB7 subcomplex binds single-stranded DNA and RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eukaryotic RPB4 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015726696.1">
        <property type="nucleotide sequence ID" value="XM_015871210.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TZC9"/>
    <dbReference type="SMR" id="A0A8C2TZC9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005027143.1">
        <property type="protein sequence ID" value="ENSCJPP00005019623.1"/>
        <property type="gene ID" value="ENSCJPG00005015890.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107317953"/>
    <dbReference type="KEGG" id="cjo:107317953"/>
    <dbReference type="CTD" id="5433"/>
    <dbReference type="GeneTree" id="ENSGT00390000004912"/>
    <dbReference type="OrthoDB" id="2186918at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.40:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006590">
        <property type="entry name" value="RNA_pol_Rpb4/RPC9_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045222">
        <property type="entry name" value="Rpb4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005574">
        <property type="entry name" value="Rpb4/RPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038324">
        <property type="entry name" value="Rpb4/RPC9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21297">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03874">
        <property type="entry name" value="RNA_pol_Rpb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00657">
        <property type="entry name" value="RPOL4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb4/RPC9 core" evidence="10">
        <location>
            <begin position="24"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00057061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00072215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00073914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00081598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005019623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="142" mass="16325" checksum="BDF37D9AF64702EF" modified="2022-01-19" version="1">MAAGGSDPRTADVEEDASQLVFPKEFETAETLLNSEVHMLLEHRKQQNESAEDEQELSEVFMKTLNYTARFSRFKNRETIASVRSLLLQKKLHKFELACLANLCPETAEEAKALIPSLEGRFEDEELQQILDDIQTKRSFQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TZF2</accession>
    <name>A0A8C2TZF2_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TZF2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005029106.1">
        <property type="protein sequence ID" value="ENSCJPP00005021172.1"/>
        <property type="gene ID" value="ENSCJPG00005016945.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01010000222629"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005021172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="307" mass="32378" checksum="82228571F48554D8" modified="2022-01-19" version="1">PGSQNHRIINQLPSHTHHPHLVGSGGQVGQGLSLPFLLGHDQPGQVRVQLVLLVDPFLLDAVPAFLLGDAQRAGDVIPKIQPLLLGEVGDGLVVVLHLHLALPQEEVSFDRLPIQLQRPLTVGQCLVVLLHLQVAQRPVGVIHGHQRVPVLRGNHTGSGLGVLAAAEQPVAQLLVLLRAMALLGAASPRSRSRCARSRGSSSLPFPFPFLLPLHGPARPGRSGPAAPLPPAAQCDSAATPLHFRGGASRGAGHQSNVGVVAKWAWSACGRGLWACGRGLLWFPAGAPPHSRPVFRPNNPWPGSLFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TZP7</accession>
    <name>A0A8C2TZP7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Exportin-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Chromosome region maintenance 1 protein homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">XPO1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the exportin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015712243.1">
        <property type="nucleotide sequence ID" value="XM_015856757.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015712246.1">
        <property type="nucleotide sequence ID" value="XM_015856760.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032299529.1">
        <property type="nucleotide sequence ID" value="XM_032443638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TZP7"/>
    <dbReference type="SMR" id="A0A8C2TZP7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005027373.1">
        <property type="protein sequence ID" value="ENSCJPP00005019794.1"/>
        <property type="gene ID" value="ENSCJPG00005016017.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107310786"/>
    <dbReference type="KEGG" id="cjo:107310786"/>
    <dbReference type="CTD" id="7514"/>
    <dbReference type="GeneTree" id="ENSGT00940000153408"/>
    <dbReference type="OrthoDB" id="27218at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005642">
        <property type="term" value="C:annulate lamellae"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034504">
        <property type="term" value="P:protein localization to nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010824">
        <property type="term" value="P:regulation of centrosome duplication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032434">
        <property type="term" value="P:regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046825">
        <property type="term" value="P:regulation of protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:001255">
        <property type="entry name" value="Exportin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041123">
        <property type="entry name" value="CRM1_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041235">
        <property type="entry name" value="Exp1_repeat_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045065">
        <property type="entry name" value="XPO1/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014877">
        <property type="entry name" value="XPO1_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040485">
        <property type="entry name" value="XPO1_repeat_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223">
        <property type="entry name" value="EXPORTIN 1/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223:SF2">
        <property type="entry name" value="EXPORTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08767">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18777">
        <property type="entry name" value="CRM1_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18784">
        <property type="entry name" value="CRM1_repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18787">
        <property type="entry name" value="CRM1_repeat_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01102">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="9">
        <location>
            <begin position="46"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00075318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005019794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1071" mass="123157" checksum="79B420FCE8C17E6F" modified="2022-01-19" version="1">MPAIMTMLADHAARQLLDFNQKLDINLLDNVVNCLYHGEGAQQRMAQEVLTHLKEHPDAWTRVDTILEFSQNMNTKYYGLQILENVIKTRWKILPRNQCEGIKKYVVGLIIKTSSDPTCVEKEKVYIGKLNMILVQILKQEWPKHWPTFISDIVGASRTSESLCQNNMVILKLLSEEVFDFSSGQITQVKAKHLKDSMCNEFSQIFQLCQFVMENSQNAPLVHATLETLLRFLNWIPLGYIFETKLISTLIYKFLNVPMFRNVSLKCLTEIAGVSVSQYEEQFVTLFTLTMMQLKQMLPLNTNIRLAYSNGKDDEQNFIQNLSLFLCTFLKEHGQLIEKRLNLRETLMEALHYMLLVSEVEETEIFKICLEYWNHLAAELYRESPFSTSASPLLSGSQHFDVPPRRQLYLPVLSKVRLLMVSRMAKPEEVLVVENDQGEVVREFMKDTDSINLYKNMRETLVYLTHLDYADTERIMTEKLHNQVNGTEWSWKNLNTLCWAIGSISGAMHEEDEKRFLVTVIKDLLGLCEQKRGKDNKAIIASNIMYIVGQYPRFLRAHWKFLKTVVNKLFEFMHETHDGVQDMACDTFIKIAQKCRRHFVQVQVGEVMPFIDEILNNINTIICDLQPQQVHTFYEAVGYMIGAQTDQTVQEHLIEKYMLLPNQVWDSIIQQATKNVDILKDPETVKQLGSILKTNVRACKAVGHPFVIQLGRIYLDMLNVYKCLSENISAAIQANGEMVTKQPLIRSMRTVKRETLKLISGWVSRSNDPQMVAENFVPPLLDAVLIDYQRNVPAAREPEVLSTMAIIVNKLGGHITAEIPQIFDAVFECTLNMINKDFEEYPEHRTNFFLLLQAVNSHCFPAFLAIPPAQFKLVLDSIIWAFKHTMRNVADTGLQILYTLLQNVAQEEAAAQSFYQTYFCDILQHIFSVVTDTSHTAGLTMHASILAYMFNLVEEGKISTPLNPGNPVNNQMFIQEYVANLLKSAFPHLQDAQVKLFVTGLFSLNQDIPAFKEHLRDFLVQIKEFAGEDTSDLFLEERETALRQAQEEKHKLQMSVPGILNPHEIPEEMCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U0B7</accession>
    <name>A0A8C2U0B7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cAMP-responsive element-binding protein-like 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">CREBL2</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family. ATF subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2U0B7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005027707.1">
        <property type="protein sequence ID" value="ENSCJPP00005020059.1"/>
        <property type="gene ID" value="ENSCJPG00005016203.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000005388"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14709">
        <property type="entry name" value="bZIP_CREBL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000044">
        <property type="entry name" value="cAMP-responsive element-binding protein-like 2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039250">
        <property type="entry name" value="CREBL2/REPTOR-BP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21051">
        <property type="entry name" value="CAMP-RESPONSIVE ELEMENT-BINDING PROTEIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21051:SF4">
        <property type="entry name" value="CAMP-RESPONSIVE ELEMENT-BINDING PROTEIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0221">Differentiation</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="11">
        <location>
            <begin position="26"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005020059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="137" mass="15612" checksum="17C1E1542C3F80CB" modified="2022-01-19" version="1">MDDSKVVGGKVKKPGKRGRKPAKIDLKAKLERSRQSARECRARKKLRYQYLEELVSSRERAICALREELEMYKQWCMAMDQGKIPSEIKALLTGEEQGKAQQNSAKLTKAGKTEPNNSNPCKYPTIINSYFITSFIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U0D4</accession>
    <name>A0A8C2U0D4_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bromodomain and WD repeat-containing protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BRWD3</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSCJPT00005028772.1">
        <property type="protein sequence ID" value="ENSCJPP00005020911.1"/>
        <property type="gene ID" value="ENSCJPG00005016501.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183107"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05529">
        <property type="entry name" value="Bromo_WDR9_I_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000071">
        <property type="entry name" value="Bromodomain and WD repeat domain containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.1040:FF:000003">
        <property type="entry name" value="Bromodomain and WD repeat domain containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000008">
        <property type="entry name" value="Bromodomain and WD repeat domain containing 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000034">
        <property type="entry name" value="Bromodomain and WD repeat domain containing 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000328">
        <property type="entry name" value="Bromodomain and WD repeat domain containing 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052060">
        <property type="entry name" value="Bromo_WD_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057451">
        <property type="entry name" value="BRWD/PHIP_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057452">
        <property type="entry name" value="BRWD/PHIP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16266:SF25">
        <property type="entry name" value="BROMODOMAIN AND WD REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16266">
        <property type="entry name" value="WD REPEAT DOMAIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25437">
        <property type="entry name" value="BRWD1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25313">
        <property type="entry name" value="BRWD_AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_1"/>
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        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="178"/>
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    <feature type="repeat" description="WD" evidence="8">
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            <begin position="1305"/>
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            <begin position="750"/>
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            <begin position="768"/>
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    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
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    </evidence>
    <sequence length="1757" mass="198742" checksum="77FB1B7C758B447E" modified="2022-01-19" version="1">MATAAAPTQLEAELYYLIARFLQSGPCKKSAQVLVEELEEHQLIPRRLDWQGKEHRRSFEDLVAVNAHIPPDYLLRICERLGPLLDKEIPQSVLGVQTLLGVGRQSLLRAAKDFRHTLWKGSAFAALHRGRPPELPVNYGKPPNVVNILSARQLTGCGRFSHLFPTSTYQQMKMHKRILGHLSSVYCIAFDRSGRRIFTGSDDCLVKIWATDDGRLLSTLRGHSAEISDMAVNYENTLLAAGSCDKIVRVWCLRTCAPVAVLQGHSASITSIQFSPARKGTTRYLTSTGADGTICFWQWHANTMKFKDRPVKFAERSRPGVQISCSSFSSGGMFIATGSTDHVIRIYYLGSESPEKMAELESHTDKVVAVQFCNNGDSLRFVSGSRDGTARVWHYHQQEWKSVVLDMATKMTGNNVASGEDKVTKLKVTMVAWDRYDATVITAVNNFLLKVWNSSTGQLLHSLSGHDDEVFVLEAHPFDQRIVLSAGHDGNIFIWDIDKGTKIRNYFNMIEGQGHGAVFDCKFSPDGHKYYEKIPDQMFFHTDYRPLIRDANNYVLDEQTQQAPHLMPPPFLVDVDGNPHPTRFQRLVPGRENCKDEQLIPQLGYVANGDGEVVEQVIGQQTNDQDESILDGMIRELQREQDLRLINEGETLPNPPLNRSHSVNGALRSPALEIASPPNVGLRRSGQIEGVRQMHQNAPRSQMATERDLMAWSRRVVVNELPPGISKVQEECRAAKGEIEIGLYTVEKKRKPSHTLQRNDYQPGSGRSLRRNQRKRQHAYQTRSTIEHSQQGASQNSRAREESDSSSEEDETAGTSDASVDDPVATWQSDSSSSDSSSEYSDWTADAGINLQPPKRQTRQAARKICSSSEDENVKGTKGVEQKRRKLKQPRKKKPSGLLSMEGEPSEEWLAPQWILDTIPRRSPFVPQMGDEIIYFRQGHEAYVRAVRKAKIYSINMQKQPWNKMELREQEFVKTVGIKYEVGPPTLCCLKLAFLDPITGKMTGESFSIKYHDMPDVIDFLVLHQFYNEAKERNWQIGDRFRSIIDDAWWFGTVESQQPFQAEYPDSSFQCYSVHWDNGDTEKMSPWDMEPIPEGTAYPEEVGAGVPVTPDELTALLYKPQEGEWGAHSRDEECERVIRGIEQLLSLDISNPFAVPVDLSAYPMYCTVVAYPTDLTTIRRRLENRFYRRISALMWEVRYIEHNARTFNEPDSPIVKAAKIVTDVLLRFIGDQSCTDILDIYNKVKAEDLSSTDEEEEVAEVDVDSDAPGTSSGKRRVRRRIRRQPMKGSPDAWKEQCKQLLNLIYEREDSEPFRQPVDLFSYPVSTTSTLKILISQCSSFGKDYRDIVDTPMDFSTVKETLEAGNYTSPLEFYKDIRLIFCNSKAYTPNKKSRIYSMTLRLSALFENHMKNIISEYKSAMQCQKRKRPRYRKRLRSSSSSPSTSRASSPKGKQKQMKIQPKTNQNTSLPLTRTSSSVSSHGEKFSNRHPFSPSNHSPDGPLTNGDGREPRTGVKRKLISASEDEHLEEGDAEEEEKKKRELKEKSGLSSSESGESGSSSSSESRSGSDSDSETTSRTDQDYIDGDHDYSKVVQSKKPKRKIKRKFTSGKRTWQSRGTGRRGRWGRWGRWSRGGRGGRGGRGCGRGRRGGSRGGRRGRGGRGASRGATRAKRARITDDEFETLFGGQFGENVFGGRFSRPPRIRTRNEGRRTVLYNDDSDNDNFVHTEDPLNLGTSRSGRVRKMTEKARVSHLMGWNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U245</accession>
    <name>A0A8C2U245_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA helicase</fullName>
            <ecNumber evidence="4">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">ATP-dependent helicase ATRX</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">X-linked nuclear protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="primary">ATRX</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="28" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="28" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4"/>
    <dbReference type="RefSeq" id="XP_015715923.1">
        <property type="nucleotide sequence ID" value="XM_015860437.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005029269.1">
        <property type="protein sequence ID" value="ENSCJPP00005021302.1"/>
        <property type="gene ID" value="ENSCJPG00005017052.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107312762"/>
    <dbReference type="KEGG" id="cjo:107312762"/>
    <dbReference type="CTD" id="546"/>
    <dbReference type="GeneTree" id="ENSGT00940000155902"/>
    <dbReference type="OrthoDB" id="2020972at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099115">
        <property type="term" value="C:chromosome, subtelomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000779">
        <property type="term" value="C:condensed chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005721">
        <property type="term" value="C:pericentric heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016605">
        <property type="term" value="C:PML body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070087">
        <property type="term" value="F:chromo shadow domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015616">
        <property type="term" value="F:DNA translocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062072">
        <property type="term" value="F:histone H3K9me2/3 reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072711">
        <property type="term" value="P:cellular response to hydroxyurea"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030330">
        <property type="term" value="P:DNA damage response, signal transduction by p53 class mediator"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030900">
        <property type="term" value="P:forebrain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000212">
        <property type="term" value="P:meiotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035264">
        <property type="term" value="P:multicellular organism growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904908">
        <property type="term" value="P:negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010571">
        <property type="term" value="P:positive regulation of nuclear cell cycle DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032206">
        <property type="term" value="P:positive regulation of telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035128">
        <property type="term" value="P:post-embryonic forelimb morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070198">
        <property type="term" value="P:protein localization to chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072520">
        <property type="term" value="P:seminiferous tubule development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060009">
        <property type="term" value="P:Sertoli cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd11726">
        <property type="entry name" value="ADDz_ATRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18068">
        <property type="entry name" value="DEXHc_ATRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000011">
        <property type="entry name" value="Transcriptional regulator ATRX homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000377">
        <property type="entry name" value="transcriptional regulator ATRX isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="SWI2/SNF2 ATPases, N-terminal domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
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        <property type="entry name" value="ADD"/>
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        <property type="entry name" value="ADD_ATRX"/>
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        <property type="entry name" value="ATRX_C"/>
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        <property type="entry name" value="ATRX_domain-containing"/>
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        <property type="entry name" value="Helicase_ATP-bd"/>
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        <property type="entry name" value="Helicase_C-like"/>
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    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="SNF2-like_sf"/>
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        <property type="entry name" value="SNF2/RAD54-like_C"/>
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        <property type="entry name" value="SNF2_N"/>
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        <property type="entry name" value="Znf_FYVE_PHD"/>
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        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
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        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR ATRX"/>
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        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR ATRX"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="HELICc"/>
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    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0227">DNA damage</keyword>
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    <keyword evidence="18" id="KW-0238">DNA-binding</keyword>
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    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
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    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="16" id="KW-0832">Ubl conjugation</keyword>
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    <sequence length="2417" mass="273671" checksum="FA3380D83CB00B07" modified="2022-01-19" version="1">MTAEPMSESKLNTLVQKLHDFLAHSSEESEDTNSPPASSKTKSTGKSREPERSPASMENNKEEGGSSSERATFLGSSRSKRKPTVVTKYVGSDDEQILDETVNEDNSNENSENDVDMKSLPKGTVVVQPEPVLNEDKDDFKGPEFRSRNTVKMKPEVPKKRGEEGLHGIVSCTACGQQVNHFQKDSIYRHPTLKVLICKTCYKYYMSDDISRDSDGMDEQCRWCAEGGNLICCDFCHNAFCKKCILRNLGRKELSTILDENNQWHCYSCQPEPLLDLVTACDSVFENLEQLLQQNKKKTKVESEKSKIYDNTVKLSPKRNNSNCNGEEKKLDDSYSGSLTYSYKALMVPKDMLKKTKKLVETTANMNSSFVSFLKKAAENSEVSPAVQLRQLKAFRSVLSDIKKAHLALEEGLNLEIQALDVKIKEKNTKEKKTDVKSEKNEVKKDEGKEHVALKGDDTVKKHKKVVSEQPDNEPMDQDVSTVEKKDSKRTSGEDKKSGTNEEPQYEPNSTEALDMDIVSVPSSVPEDIFETLESAMEVQTAGDEQGNGNARADHENPNIKLTTPLKDTKGSKLKASAKGTKELIVKLTPVSLSESPVKSEDQDSSVEKGSKDERTEKCDSVKENSNADSERSTENEAVSLAEDSDLRRSPRVKTTPLRRPTDVNPSTSNSEEDSNDTSNEKRKRRSSKQSRRKKDKRNSSDSTVDGPRPNKLCKSKKPAVLDNSSDSDEMPAVLKEVAMMSRSSSDIDSNSELPARDQKASSVVKDQPVMDENGKRKRKSSSSGSDLDAKRGKSAKNSAVAKKKRQNYSDSSNYDSELEKEIKHLSKIESAKKAKKKYSRKEDSYDSSEEEQKRRVSKRKVNVKKQRGKSSEDDAAEKSSPENEMNHSSEDKKVSVGSNAKEKLKKNLKKEALKGKHDESSDAEKEESSPKGTKVAEGKKNKDSMKKKAQEDSSSESTEKHARKELSFDSPKEKFKTKRRSENKEKKSENLKQKSFKKEQEDSSSDVEKSSPEKGSCNSSENNKTKSETVGKERKRRNLRERVPKRIQTDLSSDADKSPLKEESSSEDAVRSKKRPEAKEKKKISHKKKIPKKEQNDSSSSDEESYEDNKKKMKKGSVKENKRSNLTEKKKISKKVILSSSSSSDKEENDEQNSTGDGSSDEQKIMPVTENLMLSAGAGFCQSSGDEGETKSRIVPVEEEEDDDDDDPENRIAKKMLLEEIKANLSSDEEASSDEESDEGKKKTGKQTENTGEDEENEKEDNSESNSEEEEDSKKPRYRHRLLRHKLTVSDGESGEEKKGKPKETKEGKRRNRRKVSSDDSNDSEFHESAVSEEVSESEDDQRPRTRSAKKAEAEENQRSYKQKKKRRRIKVPDDSSSENNNKSNSENEENDDSKSPGKGRKKIRKIIKDDKLRTETQNALKEEEERRKRIAEREREREKLREVIEIEDASPLKCPITTKLVLDEDEETKEPLVQVHRSIVTKLKPHQVDGVQFMWDCCCESVKKTKTSPGSGCILAHCMGLGKTLQVVSFLHTVLLCDKLDFRTALVVCPLNTALNWLNEFEKWQEGLEDDEKLEVCELATVKRPQERSYMLQRWQDDGGVMIIGYEMYRNLAQGRNVKSRKLKEIFNKALVDPGPDFVVCDEGHILKNEASAVSKAMNSIRSRRRIILTGTPLQNNLIEYHCMVNFIKENLLGSIKEFRNRFINPIQNGQCADSTLVDVRVMKKRAHILYEMLAGCVQRKDYTALTKFLPPKYEYVLEVRMTPIQCKLYQYYLDHLTGVGGGNEGGRGKAGAKLFQDFQMLSRIWTHPWCLQLDYISKENKGYFDEDSMDDFIASDSDETSMSLSSDDYAKKKKSKGKKGKKECSSSGSGSDNDVEVIKVWNSRSRGGGEGNVEELGNNPSSVVKSEEGKATSSSNPGSPAPDWYKDFVTDADAEVLEHSGKMVLLFEILRMAEELGDKVLVFSQSLISLDLIEDFLELANREKTDKDKPPIYKGEGKWFRNIDYYRLDGSTTAQSRKKWAEEFNDETNVRGRLFIISTKAGSLGINLVAANRVIIFDASWNPSYDIQSIFRVYRFGQSKPVFVYRFLAQGTMEDKIYDRQVTKQSLSFRVVDQQQVERHFTMNELTELYTFEPDLLDDPNSEKKKKRDTPMLPKDTILAELLQINKEYIVGYHEHDSLLDHKEEEELTEEERKAAWAEYEAEKKGLTMRFNMPTGTNVLPTNFNSQTPYIPFNLGTLSAMSNQQLEDLINQGREKVVEATNSVTAARIQPLEDIISTIWKENVTLTESQVQALALNRQASQELDVKRREAIYNDVLTKQQMLISCVQRILMNRRLQQQYNQQQQQHMSYQQTAMSHLMMPKPPNLIMNPSNYQQIDIRGMYQSVSGGMQPPPLQRAPPPMRGKNAGPSQGKSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U4K9</accession>
    <name>A0A8C2U4K9_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">RLIM</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the RNF12 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="RefSeq" id="XP_015716049.1">
        <property type="nucleotide sequence ID" value="XM_015860563.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015716050.1">
        <property type="nucleotide sequence ID" value="XM_015860564.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U4K9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005029241.1">
        <property type="protein sequence ID" value="ENSCJPP00005021282.1"/>
        <property type="gene ID" value="ENSCJPG00005017030.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107312823"/>
    <dbReference type="KEGG" id="cjo:107312823"/>
    <dbReference type="CTD" id="51132"/>
    <dbReference type="GeneTree" id="ENSGT00940000155753"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050767">
        <property type="term" value="P:regulation of neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd16674">
        <property type="entry name" value="RING-H2_RNF12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000054">
        <property type="entry name" value="E3 ubiquitin-protein ligase RLIM isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051834">
        <property type="entry name" value="RING_finger_E3_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058896">
        <property type="entry name" value="RNF6/12_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931:SF4">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RLIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931">
        <property type="entry name" value="SI:CH211-59O9.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25914">
        <property type="entry name" value="RNF6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="539"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="72"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="281"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="337"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="425"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="104"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="142"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="154"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="213"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="341"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="432"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005021282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="593" mass="65701" checksum="A9386FF16A06154F" modified="2022-01-19" version="1">MESSDSSDKGNIDQSEAQRQSQLDRLDREEAFYQFVNNLSEEDYRLMRDNNLLGTPGEITEEELLRRLHQVKEGPPQQNSDENRGAESTEDVSNGDSIIDWLNSVRQTGNTTRSGQRGNQSWRAVSRTNPNSGDFRFSLEINVNRNNGNTNPETENEPSVEPSGGEDLENSQSDSEIPRSESPSVRQPGSERSTSEELTEEASPRGQRRARSRSPEQRRTRARTDRSRSPINPVSEAPRRSHHNTSSQTFDHSAVNEAEGSSRTRQHVTLRQHAVGTEIPSENAVLFSAPETRPVPQAAGSSETNGAGESAAPGQRPPTIVLDLQVRRVRPGEYRQRDSIANRTRSRSQTPNNTVTYESERGGFRRTFSRSERAGVRTYVSTIRIPIRRILNTGLSETTSVAIQTMLRQIMTGFGELSYFMYSDSDADASGPTPNQNVDASEPQNGGGGSSSNENTDVSSGEVFEGSNEGGSTSGARREGRNTRGSVTFEESGSLPFLSLAQFFLLNEDDDDQPRGLTKEQIDNLAMRNFGESDALKTCSVCITEYTEGNKLRKLPCSHEYHVHCIDRWLSENSTCPICRRAVLASGNRESVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U4Z0</accession>
    <name>A0A8C2U4Z0_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Leucine rich repeat neuronal 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LRRN1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015730905.1">
        <property type="nucleotide sequence ID" value="XM_015875419.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U4Z0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005032304.1">
        <property type="protein sequence ID" value="ENSCJPP00005023579.1"/>
        <property type="gene ID" value="ENSCJPG00005018683.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107319991"/>
    <dbReference type="KEGG" id="cjo:107319991"/>
    <dbReference type="CTD" id="57633"/>
    <dbReference type="GeneTree" id="ENSGT00940000157154"/>
    <dbReference type="OrthoDB" id="266138at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051965">
        <property type="term" value="P:positive regulation of synapse assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000355">
        <property type="entry name" value="Leucine-rich repeat neuronal protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000481">
        <property type="entry name" value="Leucine-rich repeat neuronal protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000056">
        <property type="entry name" value="Leucine-rich repeat neuronal protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000074">
        <property type="entry name" value="Leucine-rich repeat neuronal protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000090">
        <property type="entry name" value="Leucine-rich repeat neuronal protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050467">
        <property type="entry name" value="LRFN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45842:SF22">
        <property type="entry name" value="INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN COMPLEX ACID LABILE SUBUNIT ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45842">
        <property type="entry name" value="SYNAPTIC ADHESION-LIKE MOLECULE SALM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01463">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 13" id="KW-0732">Signal</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034158666" evidence="13">
        <location>
            <begin position="24"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="631"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="14">
        <location>
            <begin position="424"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="525"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="691"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="691"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="702"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005023579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="716" mass="80874" checksum="E2DD3F6772A20011" modified="2022-01-19" version="1">MAKIRLVLTVCQVVLELLTNSLTESSVQSNECPQLCVCEIRPWFTPQSTYREATTVDCNDLRLTKIPSNLSSDTQVLLLQSNNIAKTTDELQLLFNLTELDFSQNNFTSIKDVGLSDLTQLTTLHLEENQIMEMTDYCLQDLCNLQELYINHNQISSISANAFSGLKNLLRLHLNSNKLKVIDSRWFDSTPNLEILMIGENPVIGILDMNFKPLSNLRSLVLAGMYLTDIPGNALVGLDSLESLSFYDNKLVKVPQLALEKVPNLKFLDLNKNPIHKIQEGDFRNMLRLKELGINNMGELVSVDRYALDNLPELTKLEATNNPKLSYIHRLAFRNVPALESLMLNNNALNAVYQKTVESLPNLREISIHSNPLRCDCVIHWINSNKTNIRFMEPLSMFCAMPPEYRGQQVKEVLIQDSNEQCLPMISHETFPNHLNSDIGMTVFLDCRAMAEPEPEIYWVTPLGNKVTVESLSDKYKLSNEGTLEISNIQIEDSGRYTCVAQNIEGADTRVATIRVNGTLLDGTQVLKIFVKQAESHSILVSWKVNSNVMTSNLKWSSATMKIDNPHITYTARVPVDVHEYNLTHLQPSTDYEVCLTVSNIHQQTQKSCVNVTTKNAAFALDISDQETSTALAAVMGSMFAVISLASISVYIAKRFKRKNYHHSLKKYMQKTSSIPLNELYPPLINLWEGDSDKDKDGSAETKPTQVDTSRSYYMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U5F5</accession>
    <name>A0A8C2U5F5_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">von Willebrand factor A domain containing 5B1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">VWA5B1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U5F5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005032366.1">
        <property type="protein sequence ID" value="ENSCJPP00005023640.1"/>
        <property type="gene ID" value="ENSCJPG00005018713.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158938"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013694">
        <property type="entry name" value="VIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052627">
        <property type="entry name" value="VWA_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46299:SF1">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 5B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46299">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 5B2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13757">
        <property type="entry name" value="VIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13768">
        <property type="entry name" value="VWA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51468">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VIT" evidence="2">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="660"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
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            <dbReference type="PROSITE" id="PS51468"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005023640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1001" mass="109037" checksum="7C3B1030076AABCE" modified="2022-01-19" version="1">MPGLINQSSHCPLLLTASEVTSCVSGYALGMTASLTYRNLQAQPCKGLFIFPLDEGTTVVGFEAVICQRAVTVQIKDKAKIDDLYLDSISLPDGGAPDGGGERIWSRLGNTGSQGEGEVVESGWLSCAVLPPGDPGAMFAGRYRAACDVHTHHPPFLPLRGVLWPSLTTPCSLYAGVESPTHEIRADADPSARSAKSIVITLANRHTFDRPVEILIHPSEPHMPHILMEEGDMTPAEYEQHLKGKNDFIKGIKKDPSMEIIRKRLHKDIPHHPVLMLNFCPELSAAPADLQKAAGEFIFLVDCSGSSTSIGHAKDALLVALKSLMPACLFNIITFSSTFKILFPASRTYCEVSAGLAVACESIRRMHADTGSPNILSPLKWIIRQPIRRGHPRLLFLLSHGAVDNAGMVLELLRNHSCSTRCYSFGIGPRACRRLVQGAAAVSRGIAEFLVEGERLQPKLIRSLKKAMAPVLSDVSVEWVFPESTEVLVSPLSSSCLFPGDRLVGYSIICDTSLYTSKPRAVSATLLPLSLSSLAETHISPPVQIGREPLGPECLGDALQVCPSRGVKLNVFAFPSPSLPPHASPPPGSAVQAPAGPPCCSKALYPPATAPRPHQHLTWLWDGVQGYSMPACSPHPTAGALGSQVMWERDLEAVQHPSFTFETETSSDYEPQDWDSGATRGSPRSPRASCKAVVKGLRGGEPRQWEITFDLPALLRERDGQEEGEEDVWSETFHQLAARAVIRDLELLAERERDIEHGNGASASCRPGRRYQLNAVHTSKSCNVISKYTAFVPVEQRKHRLPSIGEQLSPGQGTPGPSSIVSGGPFGDRNLLFPHTGCMWLVFRASRCSLQVSLQLACGAFLMNSAFCEAVSIPMEKLRWTSPFSCHRLQPEQWDASISEADSTDIQMLLLDIELQKQTEPEGMLWATAVALAWLEHSSASHFTEWELVAAKASLWLGEQDFPQGCSLAAVKSAAQQLFVLLRHWDENLEFNLLCYNPSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U735</accession>
    <name>A0A8C2U735_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">MOB kinase activator 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Mob2 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Mps one binder kinase activator-like 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">MOB2</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Stimulates the autophosphorylation and kinase activity of STK38 and STK38L.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Binds STK38 and STK38L.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MOB1/phocein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2U735"/>
    <dbReference type="Ensembl" id="ENSCJPT00005031969.1">
        <property type="protein sequence ID" value="ENSCJPP00005023317.1"/>
        <property type="gene ID" value="ENSCJPG00005018514.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01120000271909"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.30:FF:000003">
        <property type="entry name" value="MOB kinase activator 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="78"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="364"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="364"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00059848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00074347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00075754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00083426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005023317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="387" mass="42574" checksum="BFD777D96B8CDCB4" modified="2022-01-19" version="1">MSGALGTICSGLCRTEPVPVLLQSLIAEPWAQLPAGHVCAGGCSVCAYGKPRGKRTTVGGAAPRTRLRARPGAVARLEAERGGPGGAAAPRCPLTGRSGRGERREAAVRRVVPRGAPLRRTMVGDQCSLPAERPVHAQSPKAGLSCKMVLQAVGKVLRKSKGKPNGKKPAPEEKKLYLEPEYTKSRITDFEFKELVMLPREIDLNEWLASNTTTFFHHINLQYSTISEFCTGESCQTMAVCNTQYYWYDERGKKIKCTAPQYVDFVMSSVQKLVTDEDVFPTKYGKEFPNSFESLVKKICKYLFHVLAHIYSSHFKETLALELHGHLNTLYTHFILFIREFNLVDLKETTIMDDLTEVLCSSSGSSSNGSGNGSSNSAAAQNHVKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U8Q7</accession>
    <name>A0A8C2U8Q7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Elongation factor G, mitochondrial</fullName>
            <shortName evidence="11">EF-Gmt</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Elongation factor G 1, mitochondrial</fullName>
            <shortName evidence="11">mEF-G 1</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Elongation factor G1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">GFM1</name>
        <name evidence="11" type="synonym">EFG1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Does not mediate the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="11">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015727574.1">
        <property type="nucleotide sequence ID" value="XM_015872088.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U8Q7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005031222.1">
        <property type="protein sequence ID" value="ENSCJPP00005022767.1"/>
        <property type="gene ID" value="ENSCJPG00005018104.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107318365"/>
    <dbReference type="KEGG" id="cjo:107318365"/>
    <dbReference type="CTD" id="85476"/>
    <dbReference type="GeneTree" id="ENSGT00550000074911"/>
    <dbReference type="OrthoDB" id="198619at2759"/>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01886">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01434">
        <property type="entry name" value="EFG_mtEFG1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04097">
        <property type="entry name" value="mtEFG1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04091">
        <property type="entry name" value="mtEFG1_II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000003">
        <property type="entry name" value="Elongation factor G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000001">
        <property type="entry name" value="Elongation factor G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000022">
        <property type="entry name" value="Elongation factor G, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000008">
        <property type="entry name" value="Elongation factor G, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000539">
        <property type="entry name" value="Elongation factor G, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00054_B">
        <property type="entry name" value="EF_G_EF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047872">
        <property type="entry name" value="EFG_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004540">
        <property type="entry name" value="Transl_elong_EFG/EF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00484">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009381">
        <property type="entry name" value="PRK12740.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43636">
        <property type="entry name" value="ELONGATION FACTOR G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43636:SF2">
        <property type="entry name" value="ELONGATION FACTOR G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="9 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tr-type G" evidence="12">
        <location>
            <begin position="32"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="108"/>
            <end position="112"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="162"/>
            <end position="165"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005022767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="738" mass="82470" checksum="884C95F0587E1EAE" modified="2022-01-19" version="1">MLRAVRAARGRGRRQLLLALCRRCSSAALPNERIRNIGISAHIDSGKTTLTERVLFYTGRIAQMHEVKGKDGVGAVMDSMELERQRGITIQSAATYTMWKDTNINIIDTPGHVDFTIEVERSLRVLDGAILVLCAVGGVQCQTITVNRQMKRYNVPFLTFINKLDRMGSSPDRAVQQMRSKLQHNAAFVQIPMGLEGNFKGVIDLIEERAIYFDGTFGQTVRYDEIPAEFRAEAAERRSELIECVANSDDHLGELFLEEKIPTVADIKLAIRRATLKKSFTPVLVGSALKNKGVQPLLDAVLEYLPNPSEVENYAILNQGDSEDKAKFLLNSARDNSQPFVGLAFKLEAGRFGQLTYIRVYQGMLKKSDYIYNTRTGKRVRVQRLVRMHSDNMEDVNEVYAGDICALFGIDCASGDTFTDKTSTDISMESIHIPDPVISVAMKPSNKNDFDKFSKGLSRFTREDPTFRVHFDDESKETIVSGMGELHLEIYSQRMEREYSCPCTMGKPKVAFRENISAPVHFEYTHKKQTGGAGQYGKVIGVLEPLDPEDYTKIEFEDRTIGTNIPKQFVPAIEKGFRDACEKGPVSGHRISGVRFVLEDGAHHMVDSNEFSFIRAGEGALKQAMENAAVRLLEPIMAVEVMAPTEFQGAVIAGINRRHGVITGQDGTEGYFTLYAEVPLNDMFGYATELRSCTEGKGEYTMEYSKYHPCLPSTQEEIINKYLEATGRLPAKKGKAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U8S1</accession>
    <name>A0A8C2U8S1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">B-cell antigen receptor complex-associated protein beta chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">B-cell-specific glycoprotein B29</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Ig-beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Immunoglobulin-associated B29 protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">CD79B</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Heterodimer of alpha and beta chains; disulfide-linked. Part of the B-cell antigen receptor complex where the alpha/beta chain heterodimer is non-covalently associated with an antigen-specific membrane-bound surface immunoglobulin of two heavy chains and two light chains. Interacts with LYN.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2U8S1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005033057.1">
        <property type="protein sequence ID" value="ENSCJPP00005024225.1"/>
        <property type="gene ID" value="ENSCJPG00005019126.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154363"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071755">
        <property type="term" value="C:IgM B cell receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030183">
        <property type="term" value="P:B cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050853">
        <property type="term" value="P:B cell receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001554">
        <property type="entry name" value="B-cell antigen receptor complex-associated protein beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14334">
        <property type="entry name" value="B-CELL ANTIGEN RECEPTOR COMPLEX-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14334:SF2">
        <property type="entry name" value="B-CELL ANTIGEN RECEPTOR COMPLEX-ASSOCIATED PROTEIN BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0391">Immunity</keyword>
    <keyword evidence="13" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="9 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Immunoglobulin" evidence="21">
        <location>
            <begin position="44"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00056166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00063513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00068183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00076791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00078678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00079736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005024225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="223" mass="25821" checksum="D56AE82903F5C468" modified="2022-01-19" version="1">MGDLYTRLWVLQANLWLMAVAPVGLPCPSMSPIGSGCSGIWQHPRFMAAKKNMPVQFICYTRQPHNMRWYKAPVDKEEFQVLDQSSDRFSIQNTENYINFTIFKVSYEDNGVYVCDSKNLTEEKRQPYLCGTELRVVSRSSIQQIQSRNTLKDTIIIIQTILLVIFISVPMLLFLEKGDRKEIPDEDHTYEGLEVEQIATYEDITPFRDMKAKWTVGEHPGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U9H1</accession>
    <name>A0A8C2U9H1_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Estrogen related receptor beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">ESRRB</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the nuclear hormone receptor family. NR3 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_032300526.1">
        <property type="nucleotide sequence ID" value="XM_032444635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U9H1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005033338.1">
        <property type="protein sequence ID" value="ENSCJPP00005024465.1"/>
        <property type="gene ID" value="ENSCJPG00005019268.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107315104"/>
    <dbReference type="CTD" id="2103"/>
    <dbReference type="GeneTree" id="ENSGT00940000153433"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003707">
        <property type="term" value="F:nuclear steroid receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005496">
        <property type="term" value="F:steroid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07170">
        <property type="entry name" value="NR_DBD_ERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06946">
        <property type="entry name" value="NR_LBD_ERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.565.10:FF:000009">
        <property type="entry name" value="estrogen-related receptor gamma isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000008">
        <property type="entry name" value="estrogen-related receptor gamma isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024178">
        <property type="entry name" value="Est_rcpt/est-rel_rcp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050200">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027289">
        <property type="entry name" value="Oest-rel_rcp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48092">
        <property type="entry name" value="KNIRPS-RELATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002527">
        <property type="entry name" value="ER-like_NR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500939">
        <property type="entry name" value="ERR1-2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="14">
        <location>
            <begin position="100"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="15">
        <location>
            <begin position="208"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR002527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005024465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="433" mass="48229" checksum="FFAF346C821FC58F" modified="2022-01-19" version="1">MATEERHLSSSCGSFIKTEPSSPSSGIDAISHHSPSGSSDASGGYGIAMGGHPNGLDSPPMFNGAGIGGGSCRKRYDDCASAIMEDSPTKCEYMLNAIPKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRLDSESSTYLSLQIPPPAKKPLTKIVSHLLVAEPEKIYAMPDPTMPESDIKALTTLCDLADRELVVIIGWAKHIPGFSNLSLGDQMSLLQSAWMEILILGIVYRSLPYEDKLVYAEDYIMDEEHSRLTGLLELYLAILQLVRRYKKLKVEKEEFVTLKALALANSDSMHIEDMDAVQKLQDLLHEALQDYELSQRNEEPRRAGKLLLTLPLLRQTAAKAVQHFYSIKLQGKVPMHKLFLEMLEAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UA91</accession>
    <name>A0A8C2UA91_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribosome assembly factor mrt4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">MRTO4</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 8">Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Associates with the pre-60S ribosomal particle. Interacts with MINAS-60 (product of an alternative open reading frame of RBM10).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
            <location evidence="8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015737803.1">
        <property type="nucleotide sequence ID" value="XM_015882317.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UA91"/>
    <dbReference type="Ensembl" id="ENSCJPT00005032338.1">
        <property type="protein sequence ID" value="ENSCJPP00005023612.1"/>
        <property type="gene ID" value="ENSCJPG00005018697.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107323341"/>
    <dbReference type="KEGG" id="cjo:107323341"/>
    <dbReference type="CTD" id="51154"/>
    <dbReference type="GeneTree" id="ENSGT00390000006238"/>
    <dbReference type="OrthoDB" id="10262308at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05796">
        <property type="entry name" value="Ribosomal_P0_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1730:FF:000004">
        <property type="entry name" value="Ribosome assembly factor mrt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.105.20:FF:000002">
        <property type="entry name" value="Ribosome assembly factor mrt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033867">
        <property type="entry name" value="Mrt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040637">
        <property type="entry name" value="Ribosomal_uL10-like_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="Ribosomal_uL10-like_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051742">
        <property type="entry name" value="Ribosome_Assembly_uL10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45841:SF1">
        <property type="entry name" value="MRNA TURNOVER PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45841">
        <property type="entry name" value="MRNA TURNOVER PROTEIN 4 MRTO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17777">
        <property type="entry name" value="RL10P_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL10-like insertion" evidence="10">
        <location>
            <begin position="125"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="215"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="221"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00066238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005023612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="246" mass="28530" checksum="C687452B3D056813" modified="2022-01-19" version="1">MPKSKRDRKVSLTRTPKKGLEAKQALITELRRCVDTYKHIFIFSVANMRNNKLKDVRNAWKHSRIFFGKNKVMMVALGREPSSEYRENLHKVSEHLRGEVGLLFTNRTKEEVDEWFSNFRKVDFARAGNKATYTVSLDMGPLEQFPHSMEPQLRQLGLPTALKKGVVTLLSDYEVCKEGDILTPEQARVLKLFGYEMAEFKVTIKFLWSSETGDFEKLAGDGEDEEEEEEEKEEEEEEEDADINED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UB05</accession>
    <name>A0A8C2UB05_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Ecto-NOX disulfide-thiol exchanger 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">ENOX1</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the ENOX family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2UB05"/>
    <dbReference type="Ensembl" id="ENSCJPT00005034142.1">
        <property type="protein sequence ID" value="ENSCJPP00005025069.1"/>
        <property type="gene ID" value="ENSCJPG00005019716.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000006788"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007624">
        <property type="term" value="P:ultradian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12228">
        <property type="entry name" value="RRM_ENOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000083">
        <property type="entry name" value="Putative ecto-NOX disulfide-thiol exchanger 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038876">
        <property type="entry name" value="ENOX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056611">
        <property type="entry name" value="ENOX1/2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034140">
        <property type="entry name" value="ENOX_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16001">
        <property type="entry name" value="ECTO-NOX DISULFIDE-THIOL EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16001:SF6">
        <property type="entry name" value="ECTO-NOX DISULFIDE-THIOL EXCHANGER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23267">
        <property type="entry name" value="ENOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="130"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="295"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="414"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00061134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005025069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="622" mass="70869" checksum="0FEDFCF98E562F91" modified="2022-01-19" version="1">MLPCSCVSSLAAADGLGSIAIDTTQLNMSVTDPTAWATAMNNLGMVPVGLAGQQLVTDSICVPGFDPSLSMMTGITPINPMIPGMGLVPPPPPTDVPVVKEIIHCKSCTLFPPNPNLPPPSTRERPPGCKTVFVGGLPENATEEIIQEVFEQCGDITAIRKSKKNFCHIRFAEEFMVDKALYLSGYRMRLGSSTDKKDSGRLHVDFAQARDDFYEWECKQRMLAREERHRRKMEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVLLTWIERGEVNRRSANQFYSMVQSANSHVRRLMNEKAAHEQEMEQAKESFKNALTGILTQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAHSEQLMGIRREEEMEMSDDDSDDNPTKKLRVDDSALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKGQLFRTEESLTKDQQLQFLQQTMQGMQQQLLSIQEELNNKKSELEQAKEEQTHTQAMLKVLQEQKQTDLIEVNTEINVLTVALVNQDREKTSEKRSPGLKSEKEALLIGIISTFLHVHPFGANIEYLWSYMQQLDSRISANEIEMLLMRLPRMFKQEFTGVGATLEKRWKFCAFEGIKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UBZ1</accession>
    <name>A0A8C2UBZ1_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UBZ1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005034620.1">
        <property type="protein sequence ID" value="ENSCJPP00005025461.1"/>
        <property type="gene ID" value="ENSCJPG00005019975.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000235534"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005025461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="79" mass="8680" checksum="AA09F1F8288AC5E8" modified="2022-01-19" version="1">MPGTRPIRRTTMRRRLLPVRTLTALLMVMFSRLTLFTSVILSPTHSPACSARGVQLSWAPSLTLLGAPFPSRLTCSQVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UCJ8</accession>
    <name>A0A8C2UCJ8_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Activating signal cointegrator 1 complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">DHX37</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UCJ8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005034017.1">
        <property type="protein sequence ID" value="ENSCJPP00005024982.1"/>
        <property type="gene ID" value="ENSCJPG00005019654.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00550000074985"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000020">
        <property type="term" value="P:positive regulation of male gonad development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042255">
        <property type="term" value="P:ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd17982">
        <property type="entry name" value="DEXHc_DHX37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000014">
        <property type="entry name" value="Probable ATP-dependent RNA helicase DHX37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000895">
        <property type="entry name" value="probable ATP-dependent RNA helicase DHX37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056371">
        <property type="entry name" value="DHX37-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF99">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23362">
        <property type="entry name" value="DHX37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="350"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="547"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="154"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="231"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="632"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="259"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="633"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00014590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005024982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1240" mass="137906" checksum="53D038F05AEA942E" modified="2022-01-19" version="1">MGGYMGGYLSGWISGWVSISVDIWVGISVVPRPHPCPFLNGAPSSKAPPPTPRPRPLTYKPRPLPPCCPCAQAQSLLVTPLDPEVGCPVLHVVRPGSEMGRARRRHNWKARAGCGAEPIHTAGTEPAGLQLELELGDETPLKGIDGSNALVLPAKKEKKKKVPRAAQQQKKPLSRKQKKNLQRVLEQKEKKKQRAELLSKLSEVQASQAEMKLLYTTSKLGVGGRMFQPKRVLQEPGAAGPEKIRSISGANKRRHSSDSEPEPEGESSSSEEEEKEEEKQETEKPSASNVNSAGKPEEGMKKPVVSQQAAPAVSSKAACKPAVFVPVARSPEIQEARLKLPILAEEQVIMEAINENPIVVICGETGSGKTTQVPQFLYEAGYTSSNGIIGITEPRRVAAVSMSQRVAKEMNLSHRAVSYQIRYEGNVTDETQIKFMTDGVLLKEVQKDFLLSKYKVIIIDEAHERSMYTDILIGLLSRIVPLREKKGLPLKLIIMSATLRVEDFTDNTRLFAVTPPVLQVDARQFPVTVHFNKKTPLDDYSGECFRKVCKIHRMLPSGGILVFLTGQAEVHSLCRRLRKAFPFQKNSTAGDDDDDRKESVEEMRKFKKSRRRKKTTTLPRINLDNYAVVPVDEGNEDRDAESDDDIAGSDIDLDLGDGDSEEEEKSDSSLPLYVLPLYSLLAPEKQAKVFRPPPPGTRLCVVATNVAETSLTIPGIKYVVDCGKVKKRFYDKITGVSSFRVTWISQASANQRAGRAGRTEPGHCYRLYSSAVFMDFEKFSAPEITKRPVEDLILQMKALNIEKVINFPFPTPPPAEALAAAEELLIALGALKEPPMTGRLKEQQAAKLSCPISPLGRVMATFPVAPRYAKMLALSRQHDCLPYTITIVSAMTVRELFEEFDRPAASEEETVKLKGKKGRLVQMQKIWAGQGSLQKLGDLMVMLGAVGSCEYSGCTPKFCEENGLRYKAMLEIRRLRGQLTTAVNSVCADAGLYVDPKMKPPTEAQATYLRQIVLAGLGDHVARRVQAEELLDEKWKNAYKTALLDDPVFIHPSSVLFKQLPEFVVYQEIVETTKLYMKGVSAVEPEWIPALLPPYCHFGKPLENPPPSYCPETGQVRCHRPSVFYRVGWQLPAVEVDYPEGIDRYKYFARFLLEGKVIEKLGSYSQCLLSNPLIMLKTWSKLQPRTESLLQALVAEHCDNRDALLAAWKKNPKYLLTAYCQWIPEVMHDDVAKQWPPVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UDM9</accession>
    <name>A0A8C2UDM9_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Adenylate kinase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">AK1</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the adenylate kinase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2UDM9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005034543.1">
        <property type="protein sequence ID" value="ENSCJPP00005025390.1"/>
        <property type="gene ID" value="ENSCJPG00005019936.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158325"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019205">
        <property type="term" value="F:nucleobase-containing compound kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="210"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="265"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005025390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="324" mass="34786" checksum="583E70942953EA95" modified="2022-01-19" version="1">MQRESCCPGNIPRPQCWVPLCPCRAAHSALLPLQPDVLLHPDSSSMSTEKLKHHKIIFVVGGPGSGKGTQCEKIVHKYGYTHLSTGDLLRAEVSSGSERGKKLKAIMEKGELVPLDTVLDMLRDAMLAKADSSKGFLIDGYPREVKQGEEFEKKVRAVPLVSAVPCCAVPPYTVLAPWPCWVSHLGETWGPPDPHGDSCVPADWPPHAAALRGCGEGDDGEAAAEEGRDQWEGGRQRGDHQEAPGDLLQGYRASHRLLQGPGHRPPGERGTGRREAIHGDGPAANSPPINTAEGCSAPSLSPQLNAEGSVDEVFQQVCSYLDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UDN3</accession>
    <name>A0A8C2UDN3_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mesoderm posterior bHLH transcription factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC107318991</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015728946.1">
        <property type="nucleotide sequence ID" value="XM_015873460.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UDN3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005036866.1">
        <property type="protein sequence ID" value="ENSCJPP00005027242.1"/>
        <property type="gene ID" value="ENSCJPG00005021136.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107318991"/>
    <dbReference type="KEGG" id="cjo:107318991"/>
    <dbReference type="GeneTree" id="ENSGT00530000063712"/>
    <dbReference type="OrthoDB" id="9946827at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003007">
        <property type="term" value="P:heart morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001707">
        <property type="term" value="P:mesoderm formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032525">
        <property type="term" value="P:somite rostral/caudal axis specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18938">
        <property type="entry name" value="bHLH_TS_Mesp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000150">
        <property type="entry name" value="Mesoderm posterior protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040259">
        <property type="entry name" value="Mesogenin/MesP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20937">
        <property type="entry name" value="IP14615P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20937:SF6">
        <property type="entry name" value="MESODERM POSTERIOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="67"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="222"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005027242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="303" mass="31476" checksum="16975721A87353D9" modified="2022-01-19" version="1">MAHPAAPSLALRTASPPLDWGLPAVPEPEGYSSSSPAPSPDSCGLSPPARAPRRGPAGRRGSGVAGGPRQSASEREKLRMRRLAQAMHRLRHYLPPALAPAGQSLTKIETLRLATRYIAHLSALLGLSEEVLLLRRGAAPRHCPLCPQGLGCCQPPHPRLCPPAPWDASPPSSEGWGSPPDLHGALDAGMGTWGPLSTGPVMETCPELHGVPDMEMGLWSSPSYSPTAGSPPALHGAPASSVSSWPSPPHCAVAGTSPDHPGDPILDGGLLLPDSVDAEMVTQDISADLLSLLEALLPPQLQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UIE1</accession>
    <name>A0A8C2UIE1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RAB6-interacting golgin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">N-terminal kinase-like-binding protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">SCY1-like 1-binding protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">GORAB</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GORAB family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015725283.1">
        <property type="nucleotide sequence ID" value="XM_015869797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UIE1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005037417.1">
        <property type="protein sequence ID" value="ENSCJPP00005027729.1"/>
        <property type="gene ID" value="ENSCJPG00005021455.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107317286"/>
    <dbReference type="CTD" id="92344"/>
    <dbReference type="GeneTree" id="ENSGT00390000014886"/>
    <dbReference type="OrthoDB" id="9909311at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021904">
        <property type="term" value="P:dorsal/ventral neural tube patterning"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045880">
        <property type="term" value="P:positive regulation of smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007033">
        <property type="entry name" value="GORAB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21470:SF2">
        <property type="entry name" value="RAB6-INTERACTING GOLGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21470">
        <property type="entry name" value="RAB6-INTERACTING PROTEIN GORAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04949">
        <property type="entry name" value="Transcrip_act"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="290"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="90"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="290"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="328"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005027729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="373" mass="42123" checksum="4817B32B981D8306" modified="2022-01-19" version="1">MAGAEAWAGFTQEELRRLQRDLSEPSERPRRPHPANKNRKQVQRAQAVQQQWQQLGLQGGAAPVPPEQLLSVPAHKPCDPQQPVPTPRHNPADQRQHDSRDEQKEPVPAGPCNGSDSTRNVTPKTSTKVEKKKVELQEKSRWEILQQEQRLIEEKNKRKKALLAKAIAERSKRTQAETVKLKRIQKELQALDDMVSADIGILRNRIDQASLDYSYARKRYDKAESEYVAAKLDLQHKTEIKEHLTEHLCTIIQQNELRKARKLEELMQQLEVEADEENLELEIEVERMLQQQEAEAGRQASQSHSRAGTVKENSAPTVTTKESEHANHAAASPAPSEQLVLSENSATKSFSNMDNQTQAVNVTPGDSPARSDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y5A7</accession>
    <name>A0A8C2Y5A7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal recognition particle receptor subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">SRPRB</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SRP receptor beta subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015726665.1">
        <property type="nucleotide sequence ID" value="XM_015871179.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y5A7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005001723.1">
        <property type="protein sequence ID" value="ENSCJPP00005000985.1"/>
        <property type="gene ID" value="ENSCJPG00005001070.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107317939"/>
    <dbReference type="KEGG" id="cjo:107317939"/>
    <dbReference type="CTD" id="58477"/>
    <dbReference type="GeneTree" id="ENSGT00940000156055"/>
    <dbReference type="OrthoDB" id="41266at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04105">
        <property type="entry name" value="SR_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019009">
        <property type="entry name" value="SRP_receptor_beta_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09439">
        <property type="entry name" value="SRPRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005000985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="258" mass="28086" checksum="EE5940D9900BAED8" modified="2022-01-19" version="1">MAGAVEPYLDSLRRELQSPGPAALSVLVALLVVAFTLLLWRLAQGARSSRRAVLLLGLCDAGKTLLFARLLTGRYRDTQTSITDSAAVYRVSNDKGTNVTLIDLPGHESLRLQFLERFKAAARAIVFVVDSVAFQREVKDVAEFLYQVLVDSTVLKNAPALLIACNKQDVTMAKSAKLIQQQLEKELNTLRVTRSAAPTSLDASATGGPAQLGKKGKDFDFSQLPMKVEFVECSARGSKGEEGDADFEDLEKWLAKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y6U8</accession>
    <name>A0A8C2Y6U8_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C-C motif chemokine</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC107322695</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV).</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Self-associates. Also heterodimer of MIP-1-alpha(4-69) and MIP-1-beta(3-69). Interacts with CCR1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the intercrine beta (chemokine CC) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015736486.1">
        <property type="nucleotide sequence ID" value="XM_015881000.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y6U8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005007193.1">
        <property type="protein sequence ID" value="ENSCJPP00005004262.1"/>
        <property type="gene ID" value="ENSCJPG00005004275.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107322695"/>
    <dbReference type="KEGG" id="cjo:107322695"/>
    <dbReference type="GeneTree" id="ENSGT00960000188078"/>
    <dbReference type="OrthoDB" id="9930747at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048020">
        <property type="term" value="F:CCR chemokine receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008009">
        <property type="term" value="F:chemokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061844">
        <property type="term" value="P:antimicrobial humoral immune response mediated by antimicrobial peptide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070098">
        <property type="term" value="P:chemokine-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00272">
        <property type="entry name" value="Chemokine_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039809">
        <property type="entry name" value="Chemokine_b/g/d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000827">
        <property type="entry name" value="Chemokine_CC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001811">
        <property type="entry name" value="Chemokine_IL8-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036048">
        <property type="entry name" value="Interleukin_8-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12015:SF183">
        <property type="entry name" value="C-C MOTIF CHEMOKINE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12015">
        <property type="entry name" value="SMALL INDUCIBLE CYTOKINE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00048">
        <property type="entry name" value="IL8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00199">
        <property type="entry name" value="SCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54117">
        <property type="entry name" value="Interleukin 8-like chemokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00472">
        <property type="entry name" value="SMALL_CYTOKINES_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="3 9" id="KW-0202">Cytokine</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034782570" description="C-C motif chemokine" evidence="9">
        <location>
            <begin position="27"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Chemokine interleukin-8-like" evidence="10">
        <location>
            <begin position="30"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005004262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="95" mass="10548" checksum="9B9888188E2AC60B" modified="2022-01-19" version="1">MKSSTAAIAVLTVAVLCFQVSSTTLAVGSFGRCCYQFLNKALPRNKVMMYEYTGSKCPYHGVIFTTFEGKMCCARPEEQWVQDILNVGKHKDGIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y7Z9</accession>
    <name>A0A8C2Y7Z9_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein Smaug homolog 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Sterile alpha motif domain-containing protein 4A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">SAMD4A</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Dendrite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Synapse</location>
            <location evidence="10">Synaptosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMAUG family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015721304.1">
        <property type="nucleotide sequence ID" value="XM_015865818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y7Z9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005010556.1">
        <property type="protein sequence ID" value="ENSCJPP00005006755.1"/>
        <property type="gene ID" value="ENSCJPG00005006252.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107315439"/>
    <dbReference type="CTD" id="23034"/>
    <dbReference type="GeneTree" id="ENSGT00940000157933"/>
    <dbReference type="OrthoDB" id="2155283at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001650">
        <property type="term" value="C:fibrillar center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030371">
        <property type="term" value="F:translation repressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd09557">
        <property type="entry name" value="SAM_Smaug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000013">
        <property type="entry name" value="Protein Smaug homolog 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.170:FF:000001">
        <property type="entry name" value="Protein Smaug homolog 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.170:FF:000002">
        <property type="entry name" value="Protein Smaug homolog 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.170">
        <property type="entry name" value="Smaug, PHAT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037093">
        <property type="entry name" value="PHAT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058599">
        <property type="entry name" value="PHAT_Smg/ZCCHC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050897">
        <property type="entry name" value="SMAUG/VTS1_RNA-bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037634">
        <property type="entry name" value="Smaug_SAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12515:SF8">
        <property type="entry name" value="PROTEIN SMAUG HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12515">
        <property type="entry name" value="STERILE ALPHA MOTIF DOMAIN CONTAINING PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26034">
        <property type="entry name" value="PHAT_SMAUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0770">Synapse</keyword>
    <keyword evidence="6" id="KW-0771">Synaptosome</keyword>
    <keyword evidence="7" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="SAM" evidence="14">
        <location>
            <begin position="320"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="278"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="419"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="559"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="425"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="442"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="705" mass="77919" checksum="5655ADC850465425" modified="2022-01-19" version="1">MMFRDQVGVLAGWFKGWNECEQTVALLSLLKRVSRTQARFLQLCLEHSLADCTELHVLEGEANNPGIINQWQQESKDKVISLLLTHLPLLKPGNIEAKVEYMKLLPKILAHSIEHNQHIEESRQLLSYALIHPATSLEDRSALAMWLNHLEDRTSGTFGSQGRGRSDSVDYGQTHYYHQRQNSDDKLNGWQNSRDSGISVSASSWQDKNLACENGHLPLYSSSSVPTTINTIGTSTSTILSGQTHHSPLKRSVSLTPPMNVPNQPLGHGWMSHEDLRARGPQCIPSDHAPLSPQSSVASSGSGGSEHLEDQPSARNTFQEEGSGMKDVPAWLKSLRLHKYAALFSQMTYEEMMALTECQLEAQNVTKGARHKIVISIQKLKERQNLLKSLERDILEGGNLRVPLQELHQMILTPIKAYSSQISSPEEHSRDTDSHHPPSLLGSDSQGSDGKDSAAGAMQQHHLPGCEGESGGGPLPEGDLPGQFTRVMGKVCTQLLVSRPDEENISSYLQLIDKCLIHEAFTEIQKKRLLSWKQQVQKLFRSFPRKSLLELSGYRQQRSRGFGQSNSLPTAGSAGAGLGRRNPRQFQIPSRNLPTARLGLLGPSGLLGTPQRSPAASPAILKQGRQNLWFANPGGSNSMPSRSHSSVQRTRSLPVHTSPQTMLMFQQPEFQVPVTEPDINNRLESLCLSMTEHALSDGVDRTSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y846</accession>
    <name>A0A8C2Y846_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Leucine rich repeat and fibronectin type III domain containing 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LRFN1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y846"/>
    <dbReference type="Ensembl" id="ENSCJPT00005010946.1">
        <property type="protein sequence ID" value="ENSCJPP00005007043.1"/>
        <property type="gene ID" value="ENSCJPG00005006499.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107307367"/>
    <dbReference type="KEGG" id="cjo:107307367"/>
    <dbReference type="GeneTree" id="ENSGT00940000160922"/>
    <dbReference type="OrthoDB" id="6159398at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050467">
        <property type="entry name" value="LRFN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45842:SF7">
        <property type="entry name" value="LEUCINE-RICH REPEAT AND FIBRONECTIN TYPE III DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45842">
        <property type="entry name" value="SYNAPTIC ADHESION-LIKE MOLECULE SALM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01463">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034691177" evidence="9">
        <location>
            <begin position="17"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="507"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="273"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="11">
        <location>
            <begin position="400"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="367"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="580"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="599"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005007043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="638" mass="66460" checksum="37795AC273AA8E07" modified="2022-01-19" version="1">MMAKLLVPLVVLGAVAQRCPPRCLCPTAAPSPTLLCARTGLLAVPPSLDRGAVELRLADNFIGAVGRADFANMSSLVHLTLSRNGLRRLAPGAFADLRALRALHLDGNRLPALSGPQLRGLASLRHLILANNQLAAIEPAAFAAFASTVEDLDLSHNNLPALPWDAVASMASLATLTLDHNLLERVPAAALSSLPRLARLDLTANRLRALPPVPGPPGPSLAAGGNPLHCNCELLWLRRLAKPDGLESCASPPSLAGRLLWAVPEEELACRAPHIAGAAASPSAVLEGQPLHLGCAANGDPPPALHWLGPDGRLVQNGSRRAVGADGSLQLRVATLLDHGAFTCVASNAAGEAAARVEVAVLPLPVQQHQHGDGDGEAQSNPSPSDMARAGANESVHAGAERRIVAAELTASSARIHWLPQRHVPGLRMIQIQYNSSSDDSLVYRLLPPSTRSFVLRDLASGREYDLCVSALYAEAVAAPPVSRPLGCVRFSTAGGSAGCAAPRPHFLGGTVIIVIGAAIAASVLVFILILTARYKAARRPPAAVASVCSQTNGTHRAPEPEPPPLQPAVMAAAVPAAPPTLNASGSGGSRALFPSHSFPRRSRTRRHGSLPRLDAPDAMPALRPSFGSTHWMLESTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y8Q2</accession>
    <name>A0A8C2Y8Q2_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cerebellin 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">CBLN2</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015710709.1">
        <property type="nucleotide sequence ID" value="XM_015855223.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015710710.1">
        <property type="nucleotide sequence ID" value="XM_015855224.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y8Q2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005012591.1">
        <property type="protein sequence ID" value="ENSCJPP00005008280.1"/>
        <property type="gene ID" value="ENSCJPG00005007436.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107309993"/>
    <dbReference type="KEGG" id="cjo:107309993"/>
    <dbReference type="CTD" id="147381"/>
    <dbReference type="GeneTree" id="ENSGT00940000159988"/>
    <dbReference type="OrthoDB" id="10070467at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043083">
        <property type="term" value="C:synaptic cleft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098820">
        <property type="term" value="C:trans-synaptic protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099558">
        <property type="term" value="P:maintenance of synapse structure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051965">
        <property type="term" value="P:positive regulation of synapse assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098814">
        <property type="term" value="P:spontaneous synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007416">
        <property type="term" value="P:synapse assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099550">
        <property type="term" value="P:trans-synaptic signaling, modulating synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.40:FF:000002">
        <property type="entry name" value="Cerebellin 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050822">
        <property type="entry name" value="Cerebellin_Synaptic_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22923:SF50">
        <property type="entry name" value="CEREBELLIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22923">
        <property type="entry name" value="CEREBELLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00007">
        <property type="entry name" value="COMPLEMNTC1Q"/>
    </dbReference>
    <dbReference type="SMART" id="SM00110">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50871">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034511316" evidence="6">
        <location>
            <begin position="40"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="C1q" evidence="7">
        <location>
            <begin position="76"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005008280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="212" mass="22860" checksum="8461380A5DA2F4D0" modified="2022-01-19" version="1">MGRRRRGALPEAAGGCCCCLAAALPLLLLLLPAGCPVRAQNDTEPIVLEGKCLVVCDSSPSADGAITSSLGISVRSGSAKVAFSAIRSTNHEPSEMSNRTMTIYFDQVLVNIGNHFDLASSIFVAPRKGIYSFSFHVVKVYNRQTIQVSLMQNGYPVISAFAGDQDVTREAASNGVLLLMEREDKVHLKLERGNLMGGWKYSTFSGFLVFPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y9J3</accession>
    <name>A0A8C2Y9J3_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Gamma-aminobutyric acid receptor subunit alpha-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">GABA(A) receptor subunit alpha-1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="primary">GABRA1</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>chloride(in) = chloride(out)</text>
            <dbReference type="Rhea" id="RHEA:29823"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="21">Postsynaptic cell membrane</location>
            <topology evidence="21">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA1 sub-subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015731852.1">
        <property type="nucleotide sequence ID" value="XM_015876366.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015731853.1">
        <property type="nucleotide sequence ID" value="XM_015876367.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y9J3"/>
    <dbReference type="SMR" id="A0A8C2Y9J3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005014884.1">
        <property type="protein sequence ID" value="ENSCJPP00005009997.1"/>
        <property type="gene ID" value="ENSCJPG00005008755.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107320465"/>
    <dbReference type="KEGG" id="cjo:107320465"/>
    <dbReference type="CTD" id="2554"/>
    <dbReference type="GeneTree" id="ENSGT00940000159136"/>
    <dbReference type="OrthoDB" id="203862at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043197">
        <property type="term" value="C:dendritic spine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902711">
        <property type="term" value="C:GABA-A receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098982">
        <property type="term" value="C:GABA-ergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004890">
        <property type="term" value="F:GABA-A receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022851">
        <property type="term" value="F:GABA-gated chloride ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904315">
        <property type="term" value="F:transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007214">
        <property type="term" value="P:gamma-aminobutyric acid signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904862">
        <property type="term" value="P:inhibitory synapse assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051932">
        <property type="term" value="P:synaptic transmission, GABAergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd19034">
        <property type="entry name" value="LGIC_ECD_GABAAR_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19052">
        <property type="entry name" value="LGIC_TM_GABAAR_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000001">
        <property type="entry name" value="Gamma-aminobutyric acid A receptor subunit alpha-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000002">
        <property type="entry name" value="Putative gamma-aminobutyric acid receptor subunit alpha-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001390">
        <property type="entry name" value="GABAAa_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005431">
        <property type="entry name" value="GABBAa1_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047024">
        <property type="entry name" value="Gabra-1-6_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047079">
        <property type="entry name" value="GABRA1_ECD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="15" id="KW-0868">Chloride</keyword>
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    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="18 22" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 22" id="KW-0406">Ion transport</keyword>
    <keyword evidence="17" id="KW-1071">Ligand-gated ion channel</keyword>
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    <keyword evidence="16" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 22" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0770">Synapse</keyword>
    <keyword evidence="5 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 22" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="22">
        <location>
            <begin position="1"/>
            <end position="27"/>
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    <feature type="chain" id="PRO_5034280041" description="Gamma-aminobutyric acid receptor subunit alpha-1" evidence="22">
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            <begin position="28"/>
            <end position="455"/>
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    <sequence length="455" mass="51842" checksum="23AD620C56762E8D" modified="2022-01-19" version="1">MKRLLVLCDCLWAWSLLLNALTERSYGQTSSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDVHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYTAAATSYTPNIARDPGLATIAKSATIEPKEVKPETKPAEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YAS4</accession>
    <name>A0A8C2YAS4_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Sodium channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="primary">LOC107308859</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="27" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="27" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="21">Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.</text>
    </comment>
    <comment type="function">
        <text evidence="19">Tetrodotoxin-resistant channel that mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Plays a role in neuropathic pain mechanisms.</text>
    </comment>
    <comment type="subunit">
        <text evidence="20">The channel consists of an ion conducting pore forming alpha-subunit regulated by one or more associated auxiliary subunits SCN1B, SCN2B and SCN3B; electrophysiological properties may vary depending on the type of the associated beta subunits. Found in a number of complexes with PRX, DYNLT1 and PDZD2. Interacts with proteins such as FSTL1, PRX, DYNLT1, PDZD2, S100A10 and many others. Interacts with NEDD4 and NEDD4L.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 21">Cell membrane</location>
            <topology evidence="1 21">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.8/SCN10A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_032298869.1">
        <property type="nucleotide sequence ID" value="XM_032442978.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005018669.1">
        <property type="protein sequence ID" value="ENSCJPP00005012950.1"/>
        <property type="gene ID" value="ENSCJPG00005010965.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107308859"/>
    <dbReference type="KEGG" id="cjo:107308859"/>
    <dbReference type="GeneTree" id="ENSGT00940000154992"/>
    <dbReference type="OrthoDB" id="2984333at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001518">
        <property type="term" value="C:voltage-gated sodium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005248">
        <property type="term" value="F:voltage-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0086010">
        <property type="term" value="P:membrane depolarization during action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019228">
        <property type="term" value="P:neuronal action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13433">
        <property type="entry name" value="Na_channel_gate"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sodium channel protein"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Sodium channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sodium channel protein"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Sodium channel protein"/>
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        <property type="entry name" value="Sodium channel protein"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Voltage-dependent sodium channel 2"/>
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    </dbReference>
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        <property type="entry name" value="Voltage-gated sodium channel Nav2.1"/>
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        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="iswi atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
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        <property type="entry name" value="IQ_SCN5A_C"/>
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        <property type="entry name" value="Na_channel_asu"/>
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        <property type="entry name" value="Na_chnl_inactivation_gate"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010526">
        <property type="entry name" value="Na_trans_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043203">
        <property type="entry name" value="VGCC_Ca_Na"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10037:SF208">
        <property type="entry name" value="SODIUM CHANNEL PROTEIN TYPE 10 SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10037">
        <property type="entry name" value="VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24609">
        <property type="entry name" value="IQ_SCN5A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06512">
        <property type="entry name" value="Na_trans_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00170">
        <property type="entry name" value="NACHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="22" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="18 21" id="KW-0407">Ion channel</keyword>
    <keyword evidence="13 21" id="KW-0406">Ion transport</keyword>
    <keyword evidence="14 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="12 21" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 21" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="17 21" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="7 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 21" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="10 21" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
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    <feature type="transmembrane region" description="Helical" evidence="21">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
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    </feature>
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            <begin position="1047"/>
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    </feature>
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    <feature type="transmembrane region" description="Helical" evidence="21">
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            <begin position="1573"/>
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        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="24">
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            <begin position="130"/>
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    </feature>
    <feature type="domain" description="Ion transport" evidence="24">
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        </location>
    </feature>
    <feature type="domain" description="Sodium ion transport-associated" evidence="25">
        <location>
            <begin position="809"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="24">
        <location>
            <begin position="1041"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="24">
        <location>
            <begin position="1360"/>
            <end position="1609"/>
        </location>
    </feature>
    <feature type="domain" description="SCN5A-like C-terminal IQ motif" evidence="26">
        <location>
            <begin position="1721"/>
            <end position="1753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="439"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="948"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="22">
        <location>
            <begin position="21"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="439"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="463"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="948"/>
            <end position="962"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00025291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU361132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF06512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF24609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005012950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1816" mass="206490" checksum="95F38A159990919D" modified="2022-01-19" version="1">MDPLYWPPETICFQRFTPESLAAIEKKIAEKKEKQAKRKQENTDQEVEEDKVTPQLDLKTYKKLPSLYGDVPVELIGEPLEDLDPYYSDHRTFMVINKRRIIFRFTATPALCILGPFNPIRKVAIKILIHSLFVGFITCTVILNCASMAINNPPPEFNKTEHIFTAIYTGEILIKVVARGLFWNEFTFLRDPWNILDFVVLVVTYVSICTTSGNVSALRTFRVLRTLKAISVIPGLKVIVNSLLESVKKLTDVLILTVFCLSIFALIGLQLFMGNLRNKCVLTNVTFNDTFCKEAKIYNASETDICARMNGTADILLCGYGGNSTGECPENYTCVKHGKNPDFGYTSFDHFGWAFLSLFRLMTQDSWERLYRQTIRSSGKSYILFFIAVIFLCSFYLFNLILAVVTMAYEEQNRATLAETQAKEKLLEEAKKILEKEQMLSTGESNKPSHIGSEMSVSGLENSQEKETRGEKPVSRQSLIVGGQSNEESLFHSQPDHCHKKLRQILLSYELSVDSINDPFRRQRLMSAATVITDNMKLQNSKARFTTVWKRLGQKYLIWNCCPFWRKVKGKVQLIALDPLLDLIIMICIIVNTFFMALEHPGMTDEEKKLICISDKVFTMIFAAEMVLKIIALDPYYYFQQKWNVFDSIVVMIGLISFHKNLSFLRLLRIFKLAKMWPALNTLMKIILNSVGALGNLTLVLIITVFIFAVVGKQVLGKYYITNFYKISTSKELRWHMKDFYHSFLVIFRILCGEWIETMWECMEVAGQGPCLLIFLLVLVIGNLVVLNLFIALLLSSFSTDSSLGQEEDAKKSKCEIAIARICKGLQSVKERILDKCGKMMERSNKTSAKKKTSVKTSFKDLEKNNYAMADLGKGMDSSCFDIGCYNNEGSSSVERKCEGSLNYHTGHIPLAVAEAYTDEGDGDEQSVCTERENRKWEDRVRHREQCRNSSRLSQISSTSETYQKKEQEEGFDVGSYSEASTVDPVTLIELYPEPKKAHLPKDCCTESCVKCFPCCNVDTTKFPGSTWWKFRKTCYKIVNHSWFENFIIFIIVLSSAALAFEDIHLEKRRTVKKLLEYADIVFTYIFIMEMLLKWVAYGLQSYFTNTWCCLDFIIVCLSCVSWGLRKNSQQSSQCSSESALKSLRTLRALRPLRALSRFEGIKVVVNALLGAIPSILNVLLVCVVFWLLFNIVGVKLLGQKFWKCVLKAGDNRGVENKSDCESYGGKWTNSDVNFDHVGMGYLALLQVATFKGWMDIMYAAVDSREIGQQPEFEAFLPMYSYFVIFIIFGSFFMLNLFIGVVISNFNQQRKKLGGKDLFLTEEQKKYYNALKKLGAKKPQRPIPRPLNAFQGFFFDIVSHKAFDVSVVTLICLNMVVMMAESDNGDVREVLKRINYFFVAVFTGECVIKIIALRHYFFTTGWNIFDLVVVVLSLVSIALSEVFSKFISPTLLRIIRLARIGRILRLVKRAKGIRTLLFALLMSLPSLFNIGLLLFLVMFIYAIVGMTNFACLAWEGGINNLFNFQTFDSSILCLFQITTSAGWDGLLSPVLKESKTCAPNLPDKNSTNCRNKVVGITFFVSYVIISFLIVVNMYIAVILENFSVATEESADPLSEDDFDMFYETWGNFDPQATQFIEYSALSDFADALAEPLRIPKPNTVQLISMDLPIVSGDKIHCLDILLAFTKRVLGEAGNFEDLELHMEEKFMAANPSTASYKPITTTLKRKQEEVSALVIQRAFRRHLLQRTMKHKPFLHCRRRFNSAACAEEIHEKDGLIASMLSENYGRKLNKSQTTSSISLPLFYDGIAGADTDKVGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YCE3</accession>
    <name>A0A8C2YCE3_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Paxillin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">PXN</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Focal adhesion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cell cortex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the paxillin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015733445.1">
        <property type="nucleotide sequence ID" value="XM_015877959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YCE3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005023020.1">
        <property type="protein sequence ID" value="ENSCJPP00005016353.1"/>
        <property type="gene ID" value="ENSCJPG00005013456.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107321237"/>
    <dbReference type="CTD" id="5829"/>
    <dbReference type="GeneTree" id="ENSGT00940000158897"/>
    <dbReference type="OrthoDB" id="15567at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043542">
        <property type="term" value="P:endothelial cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034446">
        <property type="term" value="P:substrate adhesion-dependent cell spreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007179">
        <property type="term" value="P:transforming growth factor beta receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09336">
        <property type="entry name" value="LIM1_Paxillin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09407">
        <property type="entry name" value="LIM2_Paxillin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09338">
        <property type="entry name" value="LIM3_Paxillin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09411">
        <property type="entry name" value="LIM4_Paxillin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000008">
        <property type="entry name" value="Paxillin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000009">
        <property type="entry name" value="Paxillin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000012">
        <property type="entry name" value="Paxillin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000018">
        <property type="entry name" value="Paxillin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.330">
        <property type="entry name" value="Nucleotidyltransferases domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047072">
        <property type="entry name" value="Paxillin_Lim_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001904">
        <property type="entry name" value="Paxillin_Lim_dom4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047075">
        <property type="entry name" value="Paxillin_TGFB1I1_LIM_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017305">
        <property type="entry name" value="Tgfb1i1/Leupaxin/TGFB1I1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216:SF11">
        <property type="entry name" value="PAXILLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216">
        <property type="entry name" value="PAXILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03535">
        <property type="entry name" value="Paxillin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037881">
        <property type="entry name" value="Leupaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00832">
        <property type="entry name" value="PAXILLIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="10" id="KW-0965">Cell junction</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11 14 15" id="KW-0440">LIM domain</keyword>
    <keyword evidence="6 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 15" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="17">
        <location>
            <begin position="324"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="17">
        <location>
            <begin position="384"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="17">
        <location>
            <begin position="442"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="17">
        <location>
            <begin position="502"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="11"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="156"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="226"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="121"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="237"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR037881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005016353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="559" mass="61281" checksum="EF49195A0F8002A5" modified="2022-01-19" version="1">MDDLDALLADLESTTSHISKRPVFLTEETPYSYPTGNHTYQEIAVPPPVPPPPSSEALNGTVIDPLDQWQPNVSRYAHQQPQSQSPIYSSSAKSSSTSVPRDGLSSPSPRASEEEHVYSFPNKQKSAEPSPTMTSTSLGSNLSELDRLLLELNAVQHNPPSGFPADEVSRSPSLPNVAGPHYVIPESSSSAGGKAAPPTKEKPKRNGGRGIEDVRPSVESLLDELESSVPSPVPAITVSQGEVSSPQRVTASQQQTRISASSATRELDELMASLSDFKFMAQGKAGGSSSPPSTTPKPGSQLDTMLGSLQSDLNKLGVATVAKGVCGACKKPIAGQVVTAMGKTWHPEHFVCTHCQEEIGSRNFFERDGQPYCEKDYHNLFSPRCYYCNGPILDKVVTALDRTWHPEHFFCAQCGVFFGPEGFHEKDGKAYCRKDYFDMFAPKCGGCARAILENYISALNTLWHPECFVCRECFTPFINGSFFEHDGQPYCEVHYHERRGSLCSGCQKPITGRCITAMGKKFHPEHFVCAFCLKQLNKGTFKEQNDKPYCQNCFLKLFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YCL7</accession>
    <name>A0A8C2YCL7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Parvalbumin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC107320558</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the parvalbumin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015731986.1">
        <property type="nucleotide sequence ID" value="XM_015876500.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YCL7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005023219.1">
        <property type="protein sequence ID" value="ENSCJPP00005016534.1"/>
        <property type="gene ID" value="ENSCJPG00005013570.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107320558"/>
    <dbReference type="KEGG" id="cjo:107320558"/>
    <dbReference type="GeneTree" id="ENSGT00940000163861"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16255">
        <property type="entry name" value="EFh_parvalbumin_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000060">
        <property type="entry name" value="Parvalbumin, thymic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008080">
        <property type="entry name" value="Parvalbumin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11653:SF4">
        <property type="entry name" value="ONCOMODULIN-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11653">
        <property type="entry name" value="PARVALBUMIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01697">
        <property type="entry name" value="PARVALBUMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0106">Calcium</keyword>
    <keyword evidence="2 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="39"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="78"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR608080-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005016534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="109" mass="12089" checksum="FDA3BB18B7D59757" modified="2022-01-19" version="1">MSLTDILSPSDIAAALRDCQAPDSFSPKKFFQISGMSKKSSSQLKEIFRILDNDQSGFIEEDELKYFLQRFECGARVLTASETKTFLAAADHDGDGKIGAEEFQELVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YF29</accession>
    <name>A0A8C2YF29_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Anoctamin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ANO1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the anoctamin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2YF29"/>
    <dbReference type="Ensembl" id="ENSCJPT00005029975.1">
        <property type="protein sequence ID" value="ENSCJPP00005021876.1"/>
        <property type="gene ID" value="ENSCJPG00005016846.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157182"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005229">
        <property type="term" value="F:intracellularly calcium-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015111">
        <property type="term" value="F:iodide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070254">
        <property type="term" value="P:mucus secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032394">
        <property type="entry name" value="Anoct_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007632">
        <property type="entry name" value="Anoctamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049452">
        <property type="entry name" value="Anoctamin_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308:SF13">
        <property type="entry name" value="ANOCTAMIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16178">
        <property type="entry name" value="Anoct_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04547">
        <property type="entry name" value="Anoctamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="424"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="501"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="579"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="625"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="669"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="795"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin dimerisation" evidence="11">
        <location>
            <begin position="148"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin transmembrane" evidence="10">
        <location>
            <begin position="413"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="171"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1016"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1025"/>
            <end position="1047"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU280814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005021876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1047" mass="120256" checksum="7D515DAD474CA88B" modified="2022-01-19" version="1">MYERSLESAVVPDWDVGLQPVPRKQVSASQKSPLCVPAAGILTGVPTAGFSGSGGMTHRSAMRRDEAEISDTDSDFHGVDFLPDNLSEVPDESGMRVNKKYSCLPAEEKGIHIINIRAIEDIGYDQHESTLLNSLSKNPDADCKYGLYFRDGKRKVDYILVYHYKKSSAGRTLTRRSQHNDAGARSTKQDPLPGKSLQMEMGESEPHADCHEDDKRFRREEYEGNLVEAGLELEHDEDTKIHGVGFVKIHAPWNVLCREAEFLKLKMPTKKMYQINQTHGLLKKINSVIQKITEPIQPKVAEHKPQTVKRLSYPFSREKQHLFDLSDRDSFFDSKTRSSAFGRKKESALLNKRRKCGKYGITSLLANGVYSAAYPLHDGDYEGENVEPNDRKLLCEEWASYGVFYKYQPIDLVRKYFGEKIGLYFAWLGVYTQMLIPASIVGIIVFLYGCATVDENIPSMEMCDERNNITMCPLCDRTCSYWKMSSACATARASHLFDNPATVFFSVFMALWAATFMEHWKRKQMRLNYRWDLTGFEEEEAHPRAEYEAKVLEKSLRKEHKHKETDKEKLTWKDRFPAYLTNFVGIIFMVGLTFAIVFGVIIYRISTAAALAISATPSGRSSVRVTVTATAVIINLVVIIFLDEVYGCIARWLTQIEVPKTDKNFEERLIFKAFLLKFVNAYTPIFYVAFFKGRFVGRPGDYVYIFHSFRMEECAPGGCLMELCIQLSIIMLGKQLIQNNLFEIGIPKMKKFIRYMKLKRRRSLDHEEHMKKKQRYEVDYNLEPFSGLTPEYMEMIIQFGFVTLFVASFPLAPLFALLNNIIEIRLDAKKFVTELRRPVAVRAKDIGIWYNILRGIGKLAVIINAFVISFTSDFIPRLVYLYMYSENGTMHGFVNHTLSSFNVSDFQAGTAPNDPMELGYEVQICRYKDYREPPWSENKYDISKDFWAVLAARLAFVIVFQNLVMFMSDFVDWIIPDIPKDISQQIHKEKVLMVEVFMREEQGKLQMLETWKDKDKKKGENCNNHSPRLSLSHSGSLSSCHSYPVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YFB9</accession>
    <name>A0A8C2YFB9_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Pyruvate dehydrogenase E1 component subunit alpha</fullName>
            <ecNumber evidence="15">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">PDHA1</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H(+) = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 15">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="15"/>
    <dbReference type="RefSeq" id="XP_015741801.1">
        <property type="nucleotide sequence ID" value="XM_015886315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YFB9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005030693.1">
        <property type="protein sequence ID" value="ENSCJPP00005022404.1"/>
        <property type="gene ID" value="ENSCJPG00005017845.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107325438"/>
    <dbReference type="CTD" id="5160"/>
    <dbReference type="GeneTree" id="ENSGT00530000063174"/>
    <dbReference type="OrthoDB" id="10256198at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02000">
        <property type="entry name" value="TPP_E1_PDC_ADC_BCADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000020">
        <property type="entry name" value="Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050642">
        <property type="entry name" value="PDH_E1_Alpha_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017597">
        <property type="entry name" value="Pyrv_DH_E1_asu_subgrp-y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03182">
        <property type="entry name" value="PDH_E1_alph_y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516:SF60">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT BACTERIAL AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13 15" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <keyword evidence="11 15" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034805743" description="Pyruvate dehydrogenase E1 component subunit alpha" evidence="16">
        <location>
            <begin position="20"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Dehydrogenase E1 component" evidence="17">
        <location>
            <begin position="74"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00051231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005022404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="399" mass="44349" checksum="E59092BB06AF84E6" modified="2022-01-19" version="1">MRKMLLAALSRVLQGPAAAAGRTASRVMVASRNYADFANEASFEIKPCDLHRLEEGPATTAVLTREEGLHYYKSMQMIRRMELKSDQLYKQKIIRGFCHLYDGQEACCVGIEAAIKPTDHVITAYRAHGFTYARGVPVREILAELTGRKGGCAKGKGGSMHMYTKNFYGGNGIVGAQVPLGAGIALACKYFGKNEVCLTLYGDGAANQGQIFETYNMAALWKLPCIFICENNRYGMGTSVERAAASTDYYKRGDFIPGIRVDGMDVLCVREAAKFAAEHCRAGKGPIVMELQTYRYHGHSMSDPGISYRTREEIQEVRSKSDPITLLKDRMINNNLASVEELKEIDVAVRKEIEEAAQFATTDPEPPLEELGNHIYFNEPPFEVRGPNQWIKYKSVSHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YGK2</accession>
    <name>A0A8C2YGK2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">WW domain-binding protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">WBP4</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in pre-mRNA splicing as a component of the spliceosome. May play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015707209.1">
        <property type="nucleotide sequence ID" value="XM_015851723.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YGK2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005034080.1">
        <property type="protein sequence ID" value="ENSCJPP00005025022.1"/>
        <property type="gene ID" value="ENSCJPG00005019684.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107308105"/>
    <dbReference type="KEGG" id="cjo:107308105"/>
    <dbReference type="CTD" id="11193"/>
    <dbReference type="GeneTree" id="ENSGT00390000013956"/>
    <dbReference type="OrthoDB" id="191651at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071005">
        <property type="term" value="C:U2-type precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070064">
        <property type="term" value="F:proline-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000767">
        <property type="entry name" value="WW domain-binding protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013085">
        <property type="entry name" value="U1-CZ_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040023">
        <property type="entry name" value="WBP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13173">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13173:SF10">
        <property type="entry name" value="WW DOMAIN-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06220">
        <property type="entry name" value="zf-U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="14">
        <location>
            <begin position="11"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="13">
        <location>
            <begin position="130"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="13">
        <location>
            <begin position="177"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="83"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="196"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="293"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="92"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="109"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="299"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="318"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="378"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00072304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005025022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="393" mass="44698" checksum="6C7E04C9587B69E1" modified="2022-01-19" version="1">MADYWKSQPKKFCDYCKCWIADNRPSIDFHERGKNHKENVAKRISEIRKKSMEKAKEEENMSKEFAAMEEAAMKAYQEDLKRLGIKPDEVGPSSTQNKTLSNTTEGKGKKEKKEKKEKKEKKKKTREGTSESPKEWVQGLSPEGYTYYYNTKTGESQWEKPKGFQGNCKNSHTGAVWVEGVSDDGHTYYYNTQTGVSTWEKPDGFVSSSNENSQRGKHSEGADSGASESDSEQEDSENEGQSPGTNIKKKGENDEESEKSPKAKKSGPYGKWREVKWQEVKWQEEAVDKEKIALASKEASNDESKTDSYGKWKAIKNEEEEEETDEKVDLELPSTENDSVLPPVLDVPEEGTVIFKEKTVTSLGDLTEGAPTFKKRKFENGKSRNLRQRLDDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YGQ3</accession>
    <name>A0A8C2YGQ3_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SPT20 homolog, SAGA complex component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">SUPT20H</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SPT20 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015707432.1">
        <property type="nucleotide sequence ID" value="XM_015851946.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YGQ3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005034461.1">
        <property type="protein sequence ID" value="ENSCJPP00005025322.1"/>
        <property type="gene ID" value="ENSCJPG00005019888.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107308212"/>
    <dbReference type="CTD" id="55578"/>
    <dbReference type="GeneTree" id="ENSGT00390000013549"/>
    <dbReference type="OrthoDB" id="1932706at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021950">
        <property type="entry name" value="Spt20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046468">
        <property type="entry name" value="Spt20-like_SEP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13526">
        <property type="entry name" value="TRANSCRIPTION FACTOR SPT20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13526:SF8">
        <property type="entry name" value="TRANSCRIPTION FACTOR SPT20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12090">
        <property type="entry name" value="Spt20_SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spt20-like SEP" evidence="3">
        <location>
            <begin position="75"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="423"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="514"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="744"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="460"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="485"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="514"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="565"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="744"/>
            <end position="762"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005025322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="769" mass="83395" checksum="F8E999FED1D8874E" modified="2022-01-19" version="1">MQQALEQALDRAEYIIESARQRPPKRKYLSSGRKSVFQKLYDLYIEECEKEPEIKKLRRNVNLLEKLVMQETLSCLVVNLYPGNEGYSLMLRGKNGSDSETIRLPYEEGELLEYLDAEELPPILVDLLEKSQVNIFHCGCVIAEIRDYRQSGNMKSPTYQSKHILLRPTMQTLICDVHSITSDNHKWTQEDKLLLESQLILATAEPLCLDPSIAVTCTTNRLLYNKQKMNTRPMKRCFKRYSKSSLNRQQEVAHYSTPPQLRLVDYVQKKKEKKVAQQYDLKISKAGNCVDMWKQNPCYLTAPSEVDVEKYAKVESSIKPDDSQPTVWPAHEVKDDYVFECEVGNQLQKTKLTIFQSLGNPLYYGKIQTLKGDDESDSLLVPPQFLIGSKTDAERVVNQYHELVKSEAKCPVKMFHNSGGSISLSHLSPGKEMEPESISGSVQSSVLGKGVKHRPPPIKLPSSSGSSSSGNIFSPQQSSGHLKSPTPPPPPPSSKPPGLSRKQSMDLNQVSMLSPAAMSPASSSQRSGTPKPSTPTPTNTPSSTPHPSDAQSSTPITPSATPTPQESGFTPQPTLLTPFAQQQMSLSQALPVMTIPLSTMVTSITTGTTSTQVMANPAGLNFINVVGSVCGAQTLMSGSNPMLGCNTGAIAPAGINLSSILPPGGLVPSALPATMQSASQAGSPFGLKNASNLRPLNLLQGSDQGPSNQDQALSAQQAAVINLTGVGNFMQPQATVAILAASNGYGSSNSSSTSSSSATSAAFRQPLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YH18</accession>
    <name>A0A8C2YH18_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="30">Thromboxane-A synthase</fullName>
            <ecNumber evidence="7">4.2.1.152</ecNumber>
            <ecNumber evidence="29">5.3.99.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="31">Cytochrome P450 5A1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="25">Hydroperoxy icosatetraenoate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="36" type="primary">TBXAS1</name>
    </gene>
    <organism evidence="36 37">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="36" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="36" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="36" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="32">Catalyzes the conversion of prostaglandin H2 (PGH2) to thromboxane A2 (TXA2), a potent inducer of blood vessel constriction and platelet aggregation. Also cleaves PGH2 to 12-hydroxy-heptadecatrienoicacid (12-HHT) and malondialdehyde, which is known to act as a mediator of DNA damage. 12-HHT and malondialdehyde are formed stoichiometrically in the same amounts as TXA2. Additionally, displays dehydratase activity, toward (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate (15(S)-HPETE) producing 15-KETE and 15-HETE.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:48856"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:57409"/>
            <dbReference type="ChEBI" id="CHEBI:57446"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:48857"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:48636"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57410"/>
            <dbReference type="ChEBI" id="CHEBI:57446"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:48637"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a hydroperoxyeicosatetraenoate = an oxoeicosatetraenoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:55556"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:59720"/>
            <dbReference type="ChEBI" id="CHEBI:131859"/>
            <dbReference type="EC" id="4.2.1.152"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:55557"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>prostaglandin H2 = (12S)-hydroxy-(5Z,8E,10E)-heptadecatrienoate + malonaldehyde</text>
            <dbReference type="Rhea" id="RHEA:48644"/>
            <dbReference type="ChEBI" id="CHEBI:57405"/>
            <dbReference type="ChEBI" id="CHEBI:90694"/>
            <dbReference type="ChEBI" id="CHEBI:566274"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>prostaglandin H2 = thromboxane A2</text>
            <dbReference type="Rhea" id="RHEA:17137"/>
            <dbReference type="ChEBI" id="CHEBI:57405"/>
            <dbReference type="ChEBI" id="CHEBI:57445"/>
            <dbReference type="EC" id="5.3.99.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:17138"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 33">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 34">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.152" evidence="7"/>
    <dbReference type="EC" id="5.3.99.5" evidence="29"/>
    <dbReference type="RefSeq" id="XP_015722799.1">
        <property type="nucleotide sequence ID" value="XM_015867313.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015722808.1">
        <property type="nucleotide sequence ID" value="XM_015867322.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032301670.1">
        <property type="nucleotide sequence ID" value="XM_032445779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YH18"/>
    <dbReference type="Ensembl" id="ENSCJPT00005035246.1">
        <property type="protein sequence ID" value="ENSCJPP00005025972.1"/>
        <property type="gene ID" value="ENSCJPG00005020297.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107316123"/>
    <dbReference type="KEGG" id="cjo:107316123"/>
    <dbReference type="CTD" id="6916"/>
    <dbReference type="GeneTree" id="ENSGT00940000157903"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106256">
        <property type="term" value="F:hydroperoxy icosatetraenoate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004796">
        <property type="term" value="F:thromboxane-A synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001516">
        <property type="term" value="P:prostaglandin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20649">
        <property type="entry name" value="CYP5A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000003">
        <property type="entry name" value="cytochrome P450 3A12-like isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050705">
        <property type="entry name" value="Cytochrome_P450_3A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24302:SF47">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24302">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="22" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="15" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="11 33 34" id="KW-0349">Heme</keyword>
    <keyword evidence="18 33 34" id="KW-0408">Iron</keyword>
    <keyword evidence="23" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="20" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="24" id="KW-0456">Lyase</keyword>
    <keyword evidence="21 35" id="KW-0472">Membrane</keyword>
    <keyword evidence="13 33 34" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19 34" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="17 34" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0643">Prostaglandin biosynthesis</keyword>
    <keyword evidence="8" id="KW-0644">Prostaglandin metabolism</keyword>
    <keyword evidence="37" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 35" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16 35" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="35">
        <location>
            <begin position="6"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="35">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="33">
        <location>
            <position position="480"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00033404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00036380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00036424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00036475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00038872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00040834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00042726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00054825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="35">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="36">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005025972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="37">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="534" mass="60703" checksum="4BC308C9EBA4972F" modified="2022-01-19" version="1">MELADLLVFASAEVNSTTVTLALLVILMVLLYWYSTSAFSKLSKVGIRHPSPLPFIGNLLFFREGFWENHTKLITEYGPVCGYYIGRQMFVVISTPEVIKQILVTDFSNFTNRIKPNLISKPMLDSILCLRDERWKYVRSLLTPAFSDAKLKEMIPLINRACDVLLSNLKVYADSGRAFDIQRCYNCFTLDVVGSVAFGTEVDSQKNPDDPFVKNCRTFFEMSLFKPLLFLILSFPSIMIPLLQILPNKKQKELNGFFIQTIKNAVVFRDQQDAAERRRDFLQWMLDSRNSADALAGGYFDKVCPATTSSQNEVPLDTTSSEKAQKMLTEDEIAGQAFLFLIAGYETTTSTLSFATYLLATNPECQEKLLQEIDEFSAKHVVTDYQNVQELPYLDMVIAETLRMFPPAFRFTREAAKDCVVLGQRIPAGAVIETAVGHLHHNPEFWPEPEKFIPERFTEEAKKERHPFAYLPFGAGPRGCIGRKMGLLETKMTLLRILQMFRFKICPETEIPLQLKSKATLGPKNGVYIILESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YHB3</accession>
    <name>A0A8C2YHB3_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein 28</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YHB3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005035977.1">
        <property type="protein sequence ID" value="ENSCJPP00005026537.1"/>
        <property type="gene ID" value="ENSCJPG00005020646.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157771"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005026537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="263" mass="29652" checksum="B67C8E51A2257725" modified="2022-01-19" version="1">MCLSLQYLTADRNHLWYVPRHLCQLPSLNELSMAGNRLAFLPLDLGRSRELQYVYVDNNIHLKGLPSFLYNKVIGCSGFRINVSLRRITAAASSSPFATNVLLIADFQYLHVKPEVGAVILKEFIMIICGSPIQVSEVKLLSFSSGQLTVFLPAEVKSIGTETDRVLPLQELAMRTLYNTYYVYLKDLNFLTPISLPKSLLELLHCPLGHCHRCSQPMFTIVYPKLFPLRETPMAGLHQGRTTVSFVAYCCSTQCLQTFDLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YHJ3</accession>
    <name>A0A8C2YHJ3_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Solute carrier family 22 member 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">SLC22A4</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">Interacts with PDZK1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Basal cell membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015731061.1">
        <property type="nucleotide sequence ID" value="XM_015875575.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YHJ3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005036591.1">
        <property type="protein sequence ID" value="ENSCJPP00005027017.1"/>
        <property type="gene ID" value="ENSCJPG00005020984.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107320084"/>
    <dbReference type="KEGG" id="cjo:107320084"/>
    <dbReference type="CTD" id="6583"/>
    <dbReference type="GeneTree" id="ENSGT00940000154155"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0009925">
        <property type="term" value="C:basal plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015651">
        <property type="term" value="F:quaternary ammonium group transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015879">
        <property type="term" value="P:carnitine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17376">
        <property type="entry name" value="MFS_SLC22A4_5_OCTN1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000070">
        <property type="entry name" value="Solute carrier family 22 member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004749">
        <property type="entry name" value="Orgcat_transp/SVOP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045915">
        <property type="entry name" value="S22A4/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00898">
        <property type="entry name" value="2A0119"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0915">Sodium</keyword>
    <keyword evidence="15" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="9" id="KW-0769">Symport</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="172"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="426"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="489"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="18">
        <location>
            <begin position="88"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005027017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="553" mass="61837" checksum="A6D63B0E78B3E2E9" modified="2022-01-19" version="1">MRDYEEVTAFLGEWGRFQRLIFFLLSASIIPNGFNGMSAVFLAGTPEHRCAVPPGANLSEEWRNASIPLELRGGLTEPSRCRRYRLAVLANLSALGLRPGSDVQLAELEQEPCLDGWEYSRDVYHSTIVTEWNLVCEDDWKVPLTTSLFFVGVLIGSFISGQLSDRFGRKSILFLTMAVQTGFSFLQIFSTSWEMFTVLFLIVGMGQISNYVVAFILGTEILGKSVRIIFSTLGVCIFFAIGYMLLPLFAYFIRDWQMLLLALTLPGLLCVPLWWIIPESPRWLISQGRYKEAEVIIRKAAKINNTPAPAVLFDATEMQDSKPQQQQKAILLDLFRTRNIATITIMSLLLWFFTSVGYFGLSLNTPNLHGDAYINCFLSAVIEVPAYIIAWLLLRSLPRRYSISSTLVLGGGVVLFIKLVPADLNVLSVCLVMLGKFGITAAFSMLYVYSVELYPTLVRNMAVGATSTASRLGSIISPYFVYLGAYDRYLPYIVMGSLTVLIGILTLFLSEGYGNALPESFEQMLKVKCFRNGQQNTSIRNSKESPKTLITTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YHM1</accession>
    <name>A0A8C2YHM1_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">G protein signaling modulator 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">GPSM2</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GPSM family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015724877.1">
        <property type="nucleotide sequence ID" value="XM_015869391.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015724878.1">
        <property type="nucleotide sequence ID" value="XM_015869392.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015724879.1">
        <property type="nucleotide sequence ID" value="XM_015869393.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015724880.1">
        <property type="nucleotide sequence ID" value="XM_015869394.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YHM1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005036803.1">
        <property type="protein sequence ID" value="ENSCJPP00005027184.1"/>
        <property type="gene ID" value="ENSCJPG00005021090.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107317117"/>
    <dbReference type="CTD" id="29899"/>
    <dbReference type="GeneTree" id="ENSGT00940000161257"/>
    <dbReference type="OrthoDB" id="286233at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097575">
        <property type="term" value="C:lateral cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097431">
        <property type="term" value="C:mitotic spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070840">
        <property type="term" value="F:dynein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001965">
        <property type="term" value="F:G-protein alpha-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005092">
        <property type="term" value="F:GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051661">
        <property type="term" value="P:maintenance of centrosome location"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904778">
        <property type="term" value="P:positive regulation of protein localization to cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905832">
        <property type="term" value="P:positive regulation of spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060236">
        <property type="term" value="P:regulation of mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009642">
        <property type="term" value="P:response to light intensity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000043">
        <property type="entry name" value="G-protein-signaling modulator 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003109">
        <property type="entry name" value="GoLoco_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052386">
        <property type="entry name" value="GPSM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45954:SF3">
        <property type="entry name" value="G-PROTEIN-SIGNALING MODULATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45954">
        <property type="entry name" value="LD33695P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02188">
        <property type="entry name" value="GoLoco"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13176">
        <property type="entry name" value="TPR_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00390">
        <property type="entry name" value="GoLoco"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50877">
        <property type="entry name" value="GOLOCO"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 10" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="244"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="459"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="459"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005027184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="663" mass="74222" checksum="CE90CE777BA0CBD2" modified="2022-01-19" version="1">MEENNVLISMREDQSFHVRYRMEASCLELALEGERLCKAGDCRAGVSFFEAAVQVGTEDLKTLSAIYSQLGNAYFYLHEYAKALEYHHHDLTLARTIGDLVGEAKASGNLGNTLKVLGNFEEAIVCCQRHLDISRELNDKVGEARALYNLGNVYHSKGKNVASAGTHDPGELPEDVKNALQKAANYYEENLTIVTELGDRAAQGRAFGNLGNTHYLLGNFRSAVLAHEQRLLIAKEFGDRSAERRAYSNLGNAYIFLGEFETASEYYKRTLQLARQLKDRAVEAQACYSLGNTYTLLQDYEKAIDYHLKHLVIAQELNDKIGEGRACWSLGNAYTALGNHDQAMHFAERHLEISREVGDRSGELTARLNLSDLQMVLGLSYSTNTSMMSESHAVDNSLNGTRPRVGRRHSMENMELMKLTPEKVQNWNSEILAKQKPLIAKPSAKLHFVNRLKGKKYKNGTTSKVLQDASNSIDSRLPNSQRRNSRETVADEGFFDLLSRFQSNRMDDQRCHFQEKNRFSAASVATSSTPPKTIRKSFSASVVSPHTDEFLDLLASSQSRRLDDQRASFSNLPGLRLNHRTSPSVLGHLMASNNRELDEDFFDILIKCQGSRLDDQRCAPPPSAKGPTVPDEDFFSLIVRSQAKRMDEQRVHLPSAIKGPSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YHQ9</accession>
    <name>A0A8C2YHQ9_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Protein tweety homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">TTYH2</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Probable chloride channel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cell membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the tweety family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015735657.1">
        <property type="nucleotide sequence ID" value="XM_015880171.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YHQ9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005037057.1">
        <property type="protein sequence ID" value="ENSCJPP00005027413.1"/>
        <property type="gene ID" value="ENSCJPG00005021257.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107322280"/>
    <dbReference type="KEGG" id="cjo:107322280"/>
    <dbReference type="CTD" id="94015"/>
    <dbReference type="GeneTree" id="ENSGT00950000183060"/>
    <dbReference type="OrthoDB" id="187568at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005229">
        <property type="term" value="F:intracellularly calcium-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072320">
        <property type="term" value="F:volume-sensitive chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015813">
        <property type="term" value="P:L-glutamate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd07912">
        <property type="entry name" value="Tweety_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006990">
        <property type="entry name" value="Tweety"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12424:SF6">
        <property type="entry name" value="PROTEIN TWEETY HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12424">
        <property type="entry name" value="TWEETY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04906">
        <property type="entry name" value="Tweety"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11 13" id="KW-0868">Chloride</keyword>
    <keyword evidence="9 13" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
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            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005027413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="534" mass="59157" checksum="8E0BA03467245F72" modified="2022-01-19" version="1">MPPARADYLAPWWAAWLHGLPHRDLRLQPVSAAFHPRDPDYQQSLLFFALVSAVCLGLNLLFLTVYLICFCCCKRDQEPDAKRPRSCCVTWMAVTAGLICCTAVGIGFYGNSETNDGVYQLLYALDNANHTLTGIDTLVASTTQQLQVALEQHLEQLTEVLAARADYLQTLKFLQQLAGSIVLQLSGLPSWHSVSDDLTALAANVGYVEYYRWLSYLLFFILVLTVCLLACLGLAKHSRCLLAMMLCCGLLTLILSWCSMAVDTAAAVGTSDFCVAPDKFIMNQTDSDISAEVVRYYLYCEQSLSSPFQQALTVFQRSLTTMQMQTQGLIQFALPLFPMAEKDLLGVQQLLNTSETSLHQLTALLDCRGLHKDYLDALIGICYDGVEGLLYLVLFSLLVAASFSTIVCAASRAWRHLVGRDQDYDDIDEEDPFNPQARRIAAHHPVRGQLRSFCSYSSSLGSQSSLHPPAQTISNAPVSEYMNQAVLFGGNPRYENVPLIGRGSPPPTYSPSMRATYLSVTDEHLRPQHTEFPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YHW4</accession>
    <name>A0A8C2YHW4_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Proline rich coiled-coil 2C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">PRRC2C</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="Ensembl" id="ENSCJPT00005037425.1">
        <property type="protein sequence ID" value="ENSCJPP00005027737.1"/>
        <property type="gene ID" value="ENSCJPG00005021459.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183161"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002244">
        <property type="term" value="P:hematopoietic progenitor cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009738">
        <property type="entry name" value="BAT2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033184">
        <property type="entry name" value="PRRC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14038">
        <property type="entry name" value="BAT2 HLA-B-ASSOCIATED TRANSCRIPT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14038:SF6">
        <property type="entry name" value="PROTEIN PRRC2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07001">
        <property type="entry name" value="BAT2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAT2 N-terminal" evidence="3">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
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        <location>
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        </location>
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        <location>
            <begin position="1161"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1184"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1208"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1260"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1333"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1381"/>
            <end position="1398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1404"/>
            <end position="1418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1421"/>
            <end position="1444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1458"/>
            <end position="1470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1573"/>
            <end position="1587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1645"/>
            <end position="1657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1686"/>
            <end position="1711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1718"/>
            <end position="1730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1782"/>
            <end position="1800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1838"/>
            <end position="1851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1871"/>
            <end position="1895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1943"/>
            <end position="1967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1991"/>
            <end position="2001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2033"/>
            <end position="2064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2085"/>
            <end position="2099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2444"/>
            <end position="2467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005027737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="2661" mass="293355" checksum="4BDA805E6191119E" modified="2022-01-19" version="1">MSEKSGQSTKAKDGKTKYATLSLFNTYKGKSLETQKTTVATRHGLQSLGKVAISRRMPPPANLPSLKAENKGNDPNVNIVPKDGTGWASKQEQHEEEKQPEVPQTQPKPAVPAPPEAAPVAKSWANTKPGGQDALPVNSYFQQEFPSLPAAGDQEKSGKEKDASEEVHGPSLRPQSKWREGGNNNSLNSPTDQEAKALGQEDGNATSAEQSDGQKAAEKRDARLPQIPQPKMNGQQQPPISSQYRAMMPPYMFNQYPRMAYPPSMQGPTRFPNSEGPRGRGPPSWCSEPIERPSILSASELKELDKFDNLDAEADEGWAGAQSEVDYTEQLNFSDDDEQGSSQKEKESGDEQTPSKDSQSPDGQKEAEEQTNAKSATQTSAAATKGSYGKSSQLDQVCIFFSLALPTLLLHPPPPDRQLGPGRQGPFPPKPVPDEDEIWKQRRRQQSEISAAVERARKRREEEERRMEEQRKAACAEKLKRLNEKFEREREREREREREREREREREKEREREKEKEREREREKEEKEKLEKAKEQEREKEKENEREKEEKEKEKEKEEEKPVHEAPEPVEPVVTPVVEKQESESRNNKEEKAVFTRQDSGRNEKEISQVTHESEPESGSQPRPAVSSGYSKQFQKSLPPRFQRQQEQMKQQQWQQQQQGVIPQSAPSQPSSGPVPPPQHRPLYQPMQPHPQHLASMGFDPRWLMMQSYMDPRMMSGRPAMDMPPIHPGIMPPKPLMRRDQLEGSATSSDSFEHIARSAREHAVPLSEPRIMWGSDPYPHAEPQQASSPPKVLEEPDNLSAAYPVEHNQLDSHPKTDFFREPGEMEVQKFPSRPLEDAQPLQTDISNTKVNFEGIDESVSRSSAEELMPVGESHSSLKRSISHGSSHSLKSEEQRNETTANIPKISSRPVESKETIERIEIKPKKEVLINNRTSEGPKLEKTFKPKSETRWGPRPGYGRREEGSDRPIRRSGPIKKPVLRDMKEEREQREEREQRKEKEGEKIASEKPSKSEKSDKKEAPQVPVPQTEPETSTSSGAPLAKKIVQDAAPTPAVSESTQAEQPLTQPAAQQQPQAQQPVTTVKEEKQAEKVVNKEVVEKPRLETRPVKREPGLPPRTYWKEARDRDWFPDQGYRGRGRGEYYSRGRSYRGSYGGRGRGSRGHNREYPHYRDTKPRTDHVPSGPVRQREESETRSESSDFEVIPKRRRQHGSETDSDSEVHESASDTLLSDKDSLIKGKHPKREERADSKKPTKPLSFKPENNIRVDNRSLEKTYVRDDENKPKPGFLPKGEPSRRGRGGMYRRGGRDPGGRPPRPSTIRRPAYRDNQWNPRQTEIIKPEDGEPPRRNEHYGPMPVDKRPPKFERKFDPTRERPRRQRPARPPRQDKPPRFRRLKEREAASKINEAVTSSSTTAAVTNAVPEPSNTALDVSGSKTPDLSNQNSSDQANEEWETASESSDFNERRERDEKKTADIAAQVAAKAGENTGAPKREIAKRSFSSQRPGIDRQNRRGNSGPAKPGRTFSGPRSDRRSGPPPRSGKRGPFEEQTASVPGVDPSNNNSLHQEEGVNAAGQKSTKDASGKKREEPKAGPKKPKEKVDALSQFDLNNYASVVIIDDHPEVTVVEDSQSNLNDDGFTEVVSKKQQKRLQDEERRKKEEQTVQVWTKKGSSEKGRGQNSKLPPRFAKKQQQQAAAAAAQQAQAQAQTPCTTQTPGQPPASVQPQNQAAGVATASTEFTVSGKVLQNTQAHNGLGTELWENKVPPTAVLNDISKKLGPISPPQPPSVSAWNKPLTSFGSATSPEGTKPGQEGGVELGIETIQFGAPASSGSDNEVGPVLSEKSTDKLPEPKEQRQKQPRAGPIKAQKLPDLSPVENKEYKPGPIGKERSLKNRKVKDAQQGEPEGQEKSSPTSVRSPEPVTVKETKATSELSTEIGTMISVSAPEFGTSTKESVTDYTTPSHPNTVATSSTKMEETLVTNVPLPHTLPLPRRETLQQSSSLTPVSPATVDLTLKMESARKAWENSPNMGEKSSPVTSAASPIAGGSSSNSSSSNAVPSSGTYSSFSSASMPPIPVASVTPTTSLSGAGTYTTSSLSTKTASTSDPPNICKVKPQQLQTSSLASASHFSQLSCMPSLIAQQQQSPQVYVSQSAAAQIPTFYMDTSHLFNTQHARLAPPSLAQQQGFQPGLSQPASVQQIPIPIYAPLQGQHQAQLSLGAAPAVSQAQELFNSSLQPYRSQQAFMQSGLSQPSPVVLSGTALHNFPTVQHQELAKAQSSLAFQQTSNTQPIPILYEHQLSQASGLGGSQLLDTHILQARATLTQASNLYSGQVQQPGQSNFYNTAQSPSALQQVTVPLPGSQLSLPNFGSTAQPLIALPQSLQPPLQHTPPQAQAQNLSRPAQVTQPFRGLIPAGTQHSMIAATGKISEMELKAFGGSIDVKPGTPPVSGRSTTPTSSPFRASSTSPNNQSNKMNSIVYQKQFQSAAAAVRMTQPFPAQFAPQILSQPNLLPPLVRAPYTNTFPAPVQRLPIVLHSQMPSQMITGLMSHPRLPHVARGLCGSVSGARGSQAQAAMKAEQDMKAKQRAEVLQSTQRFFSEQQQSKPIGGKAQKVDENGSKPSEAIADSSGVCQDKAEEKPAPAPPAATKPVRTGPIKPQAIKTEETKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0U5AEQ2</accession>
    <name>A0A0U5AEQ2_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">AvBD5 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="12">Avian beta-defensin 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">AvBD5</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Anim. Sci. J." volume="87" first="311" last="320">
            <title>Basic characterization of avian beta-defensin genes in the Japanese quail, Coturnix japonica.</title>
            <authorList>
                <person name="Ishige T."/>
                <person name="Hara H."/>
                <person name="Hirano T."/>
                <person name="Mannen H."/>
                <person name="Kono T."/>
                <person name="Hanzawa K."/>
            </authorList>
            <dbReference type="PubMed" id="26338292"/>
            <dbReference type="DOI" id="10.1111/asj.12436"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <tissue evidence="11">Bone marrow</tissue>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="journal article" date="2020" name="J. Hered." volume="111" first="436" last="443">
            <title>Analysis of the Diversity of the AvBD Gene Region in Japanese Quail.</title>
            <authorList>
                <person name="Ishige T."/>
                <person name="Hara H."/>
                <person name="Hirano T."/>
                <person name="Kono T."/>
                <person name="Hanzawa K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the beta-defensin family.</text>
    </comment>
    <dbReference type="EMBL" id="AB698001">
        <property type="protein sequence ID" value="BAT57452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AB698002">
        <property type="protein sequence ID" value="BAT57453.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AB698018">
        <property type="protein sequence ID" value="BAT57472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AB698020">
        <property type="protein sequence ID" value="BAT57491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LC509028">
        <property type="protein sequence ID" value="BBP06471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LC509029">
        <property type="protein sequence ID" value="BBP06485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LC509030">
        <property type="protein sequence ID" value="BBP06497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LC509031">
        <property type="protein sequence ID" value="BBP06513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LC509032">
        <property type="protein sequence ID" value="BBP06529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0U5AEQ2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005001712.1">
        <property type="protein sequence ID" value="ENSCJPP00005000978.1"/>
        <property type="gene ID" value="ENSCJPG00005001067.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000235483"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031731">
        <property type="term" value="F:CCR6 chemokine receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042056">
        <property type="term" value="F:chemoattractant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060326">
        <property type="term" value="P:cell chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.360.10">
        <property type="entry name" value="Antimicrobial Peptide, Beta-defensin 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001855">
        <property type="entry name" value="Defensin_beta-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20515">
        <property type="entry name" value="BETA-DEFENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20515:SF20">
        <property type="entry name" value="GALLINACIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00711">
        <property type="entry name" value="Defensin_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57392">
        <property type="entry name" value="Defensin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="7" id="KW-0044">Antibiotic</keyword>
    <keyword evidence="4" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="6" id="KW-0211">Defensin</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011370616" evidence="9">
        <location>
            <begin position="25"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-defensin-like" evidence="10">
        <location>
            <begin position="28"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAT57453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="BAT57491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="BBP06471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="BBP06513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005000978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="66" mass="7244" checksum="801C340270C0C7DA" modified="2016-03-16" version="1">MQILPLLFAVLLLMLQGEPGLSLARASPQDCERRGGFCSHSSCPPGIGRIGLCSEQVFCCRSRWYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SKC7</accession>
    <name>A0A8C2SKC7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Iduronate 2-sulfatase</fullName>
            <ecNumber evidence="15">3.1.6.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Alpha-L-iduronate sulfate sulfatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">IDS</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Lysosomal enzyme involved in the degradation pathway of dermatan sulfate and heparan sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Hydrolysis of the 2-sulfate groups of the L-iduronate 2-sulfate units of dermatan sulfate, heparan sulfate and heparin.</text>
            <dbReference type="EC" id="3.1.6.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="14">Monomer. The 58-kDa mature form is composed of two chains resulting from proteolitic processing, the 42-kDa chain and the 14-kDa chain that remain stably associated and form the 58-kDa intermediate form which is enzymatically active.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Lysosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.6.13" evidence="15"/>
    <dbReference type="RefSeq" id="XP_015716319.1">
        <property type="nucleotide sequence ID" value="XM_015860833.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SKC7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005000373.1">
        <property type="protein sequence ID" value="ENSCJPP00005000187.1"/>
        <property type="gene ID" value="ENSCJPG00005000265.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107312964"/>
    <dbReference type="KEGG" id="cjo:107312964"/>
    <dbReference type="CTD" id="3423"/>
    <dbReference type="GeneTree" id="ENSGT00940000156803"/>
    <dbReference type="OrthoDB" id="96314at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043202">
        <property type="term" value="C:lysosomal lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004423">
        <property type="term" value="F:iduronate-2-sulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030209">
        <property type="term" value="P:dermatan sulfate proteoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006027">
        <property type="term" value="P:glycosaminoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030200">
        <property type="term" value="P:heparan sulfate proteoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd16030">
        <property type="entry name" value="iduronate-2-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000027">
        <property type="entry name" value="iduronate 2-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035874">
        <property type="entry name" value="IDS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45953">
        <property type="entry name" value="IDURONATE 2-SULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45953:SF1">
        <property type="entry name" value="IDURONATE 2-SULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0458">Lysosome</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 18" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034178049" description="Iduronate 2-sulfatase" evidence="18">
        <location>
            <begin position="28"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="19">
        <location>
            <begin position="44"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00050460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00056350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00062513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00066413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00068336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00081076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005000187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="566" mass="63903" checksum="36A51CA25B8C1877" modified="2022-01-19" version="1">MAEAGRVFHCLLAALCGVFALFSPAAAASRLRTHSTTGPGDGMNVLFIVVDDLRPVLGCYGDNLVKSPNIDQLASQSIVFSNAYAQQAVCAPSRVSFLTGRRPDTTRLYDFYSYWRVHSGNYSTMPQYFKENGYMTMSVGKVFHPGVSSNYSDDYPYSWSIPPFHPSTEKYENDKTCRGKDGRLYANLVCPVDVTEMPGGTLPDIQSTEEAIRLLNVMKTKKQKFFLAVGYHKPHIPLRYPQEFLKLYPLENITLAPDPWVPEKLPPVAYNPWMDIRQRDDVKALNVTFPYGPLPDDFQRLIRQSYYAAVSYLDMQVGLLLNALDDVGLSNSTIVVFTADHGWSLGEHGEWAKYSNFDVATQVPLMFYVPGMTTSSARQGGRVFPYLDPFSHILGLGPQGQSTKMVELVSLFPTLAELAGLQVPPACPGASFHVALCTEGASIVRYFKSSEQKVLMKEDGCNDTDKCYSEEPIAFSQYPRPADTPQWDSDKPKLKDIRIMGYSMRTIDYRYTVWVQFNPENFSANFEDIHAGELYMMETDPNQDNNIYNNTLHRHLYQKMIDFLKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SRT1</accession>
    <name>A0A8C2SRT1_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Calpain 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">CAPN1</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase C2 family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSCJPT00005004157.1">
        <property type="protein sequence ID" value="ENSCJPP00005002307.1"/>
        <property type="gene ID" value="ENSCJPG00005002503.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159147"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097264">
        <property type="term" value="P:self proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00044">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000001">
        <property type="entry name" value="Calpain-1 catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022682">
        <property type="entry name" value="Calpain_domain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022683">
        <property type="entry name" value="Calpain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036213">
        <property type="entry name" value="Calpain_III_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183">
        <property type="entry name" value="CALPAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183:SF284">
        <property type="entry name" value="CALPAIN-1 CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01067">
        <property type="entry name" value="Calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00704">
        <property type="entry name" value="CALPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00720">
        <property type="entry name" value="calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49758">
        <property type="entry name" value="Calpain large subunit, middle domain (domain III)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8 14" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="11 14" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="16">
        <location>
            <begin position="73"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="832"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="835"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="active site" evidence="13 14">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="active site" evidence="13 14">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <feature type="active site" evidence="13 14">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR622684-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005002307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="861" mass="94255" checksum="FE09C9A75690C629" modified="2022-01-19" version="1">MATFNPFPPFFPPFLRRPMAEEPVVAVYCTGVSAQVQRQRAKALGLGQHQNALRFRGQDYAALRDRCLQDGTLFRDETFPPSASSLGFKELGPGSSKTRGVTWKRPTELCRHPQFIVDGATRTDICQGALGDCWLLAAIASLTLNETILHRVVPHGQSFQNGYAGIFHFQIWQFGEWEDVVVDDYLPTKDGKLLFVHSAEGTEFWSALLEKAYAKVNGCYEALSGGSTTEGFEDFTGGVTEWYDLRKPPPDLYQIILKALDRGSLLGCSIDITSAFDMEAVTFKKLVKGHAYSVTGAKQISYRGQSLGLIRMRNPWGEVEWTGAWSDNSSEWNAVEPALRQQLMVRMEDGEFWMSFRDFLREFTRLEICNLTPDALQSHKFRKWNTKLYDGSWRRGSTAGGCRNYPATFWINPQFKICLEEVDDDDDVGGREPGCSFLLALMQKHRRRERRYGKDMETIGFAVYEVSSCPSIRLSVCPSIRLSVHLSVCPSSVHLSVCLSIYLYVHLSVCPSSVHLSVCCLSYWPSGACLSACCPLVCLSVHPSVCPSSVRLSVCCLSFWPSGACLSVCLPPSVSIAFLPVTSWPVRLSLSVCLSLLGSVHPCLSLAPCLSVSVPIRLSIPACLVSLSVCPCLSSCLSLLVSAHPCLCPCLSVPVCLSVCLCLSLSVCLSLPVFLSIPPCLCPCLSVGLCLSVCPHPSYPCLPVSVSVPGHPSLSLSLLVCLSVPICLSVPVCPCLSSCLSILVCLSVPVCWSLSLPICLSVHPSLPTPHTHHLSSFPLQVPPEVCTPPPKPLTPPXXXXXXXXPPPASSPSHFLFLLPKTALFSPRKCCPKAKSMTTSSSSSSSWRGRTWRSASRSCRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SRY9</accession>
    <name>A0A8C2SRY9_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">GLIS family zinc finger 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">GLIS3</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GLI C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SRY9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005005327.1">
        <property type="protein sequence ID" value="ENSCJPP00005002909.1"/>
        <property type="gene ID" value="ENSCJPG00005003188.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156896"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome Z"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000019">
        <property type="entry name" value="GLI family zinc finger 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000031">
        <property type="entry name" value="GLI family zinc finger 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000036">
        <property type="entry name" value="GLI family zinc finger 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000048">
        <property type="entry name" value="GLI family zinc finger 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000453">
        <property type="entry name" value="GLIS family zinc finger 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043359">
        <property type="entry name" value="GLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056436">
        <property type="entry name" value="Znf-C2H2_ZIC1-5/GLI1-3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718:SF1">
        <property type="entry name" value="ZINC FINGER PROTEIN GLIS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23561">
        <property type="entry name" value="zf-C2H2_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="348"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="387"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="415"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="445"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="475"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="281"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="488"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="565"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="126"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="334"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="576"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005002909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="776" mass="84811" checksum="72D4836DDF6927C6" modified="2022-01-19" version="1">MTVHQLGPVLSPASQVSRACNQISPHLQRSMDVSSISIPPSNTRSLFSHKTLDSTTSGLSESQFTLTVKQEWSHEYGILHSPPPDQGLRNGSVLGDLLNFPPATSVSSNCVSSPLPSYILGMENSHSPNPSACNSSSQSQSTHSKKKALSLSPLSDGIGIDFNTIIRTSPTSLVAYINSSRTSPCNVSPQPEVYGHFLGVRGSCIPQNCPVPAYQKGLLMANCNITIPEFIENGAGEYQRMQQLEQISLQTDMMTNMVIQQGMFPMDSQAVGVLKNEQLDDFSGHTIDMPPPTPLLPPTPQGPPPPYHAHQHQLPHSLPHMHSLPVPPSAPDPQPEEDGDLDDFNGKHGCRWIDCNMLYDQQEELVRHIEKIHIDQRKGEDFTCFWAGCPRRLKPFNARYKLLIHMRVHSGEKPNKCTFEGCNKAFSRLENLKIHLRSHTGEKPYICQHPGCQKAFSNSSDRAKHQRTHLDTKPYACQVPGCTKRYTDPSSLRKHVKAHSSKDQQVRKKLRSSSELGQDILNDCLTIQPLQTAPSPHNAVDNALGQSPGPAHDIYPVAVFPSMQTSGSGTAAGAVSLSQPSSHPSPGCNVQSSSLHPPSQLSLLSVADSERFVAQTSSSQHISPQRISVPPSVIQRQTPQLPHLQQPAGVHLKTYESASNPFQPNSLHFQGFYGQLQTFCPPHYPDTQKDIQHNVSCSMVPPFEDCLFPASVGQAGLGVFHRTFSAHSGITVYDFPAGPTGVFGDSTHSVPEGSSFLQINTVDRCPTQLSSVYTEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SS09</accession>
    <name>A0A8C2SS09_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Branched-chain-amino-acid aminotransferase</fullName>
            <ecNumber evidence="18">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">BCAT1</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:24802"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:18322"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:24814"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="18"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2SS09"/>
    <dbReference type="Ensembl" id="ENSCJPT00005005254.1">
        <property type="protein sequence ID" value="ENSCJPP00005002867.1"/>
        <property type="gene ID" value="ENSCJPG00005003144.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000009532"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004084">
        <property type="term" value="F:branched-chain-amino-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009083">
        <property type="term" value="P:branched-chain amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.10.10:FF:000005">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.10:FF:000002">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01123">
        <property type="entry name" value="ilvE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009897">
        <property type="entry name" value="PRK13357.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825:SF70">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE, CYTOSOLIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825">
        <property type="entry name" value="SUBGROUP IIII AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 18" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 18" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="11 18" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 17" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 18" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00050522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00050614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00057137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU004517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005002867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="425" mass="47573" checksum="92FA1BFEACD9C5F0" modified="2022-01-19" version="1">MKGCENKCMAGGCSEEATKHVTESFKASDLIITPATTFKEKPDTSGLVFGTVFTDNMLTIEWSSASGWEKPCIRPLQNLSLHPACSSLHYATELFEGLKAYRGVDGKIRLFRPGLNMERMARSARRMTLPCFDQNELLECIRKLVEVEKEWVPYSTSASLYIRPTLIGTEPSLGVKKPTKALLYVILSPVGAYFSSECFNPISLWADPKYVRAWKGGTGDCKLGGNYGSSIYAQQEALELGCQQVLWLYGEDHQITEVGTMNLFLYWINEDGENELATPPLDGIILPGVTRQSILDLARNWGEFKVSERYITMSDLTAALEENRVKEMFGAGTACIVCPISKILYKGKHLHIPTMENGPQLTTRILNKLTDIQDNIGHYWLQLRKKISPNILLLPLCWWLSQLSWGQIATLLPHFHLSAVLTVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SSC0</accession>
    <name>A0A8C2SSC0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ATP-dependent 6-phosphofructokinase</fullName>
            <shortName evidence="16">ATP-PFK</shortName>
            <shortName evidence="16">Phosphofructokinase</shortName>
            <ecNumber evidence="16">2.7.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Phosphohexokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">PFKP</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16 17">
            <text>beta-D-fructose 6-phosphate + ATP = beta-D-fructose 1,6-bisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="16">Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 16 17">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Homo- and heterotetramers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.11" evidence="16"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2SSC0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005005546.1">
        <property type="protein sequence ID" value="ENSCJPP00005003068.1"/>
        <property type="gene ID" value="ENSCJPG00005003311.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155002"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005945">
        <property type="term" value="C:6-phosphofructokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070095">
        <property type="term" value="F:fructose-6-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061621">
        <property type="term" value="P:canonical glycolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990830">
        <property type="term" value="P:cellular response to leukemia inhibitory factor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00764">
        <property type="entry name" value="Eukaryotic_PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.460:FF:000001">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.460:FF:000003">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.450:FF:000043">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase, platelet type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.450:FF:000064">
        <property type="entry name" value="Phosphofructokinase, platelet b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="entry name" value="Phosphofructokinase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03184">
        <property type="entry name" value="Phosphofructokinase_I_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009161">
        <property type="entry name" value="6-Pfructokinase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041914">
        <property type="entry name" value="PFK_vert-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015912">
        <property type="entry name" value="Phosphofructokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02478">
        <property type="entry name" value="6PF1K_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697:SF5">
        <property type="entry name" value="ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE, PLATELET TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000533">
        <property type="entry name" value="ATP_PFK_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="Phosphofructokinase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00433">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4 16" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="10 16 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 16" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13 16 17" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 16 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 16 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphofructokinase" evidence="18">
        <location>
            <begin position="18"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphofructokinase" evidence="18">
        <location>
            <begin position="556"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal catalytic PFK domain 1" evidence="16">
        <location>
            <begin position="1"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal regulatory PFK domain 2" evidence="16">
        <location>
            <begin position="403"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="16">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="88"/>
            <end position="89"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="118"/>
            <end position="121"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="16">
        <location>
            <begin position="164"/>
            <end position="166"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="16">
        <location>
            <begin position="208"/>
            <end position="210"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="16">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="16">
        <location>
            <begin position="298"/>
            <end position="301"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="16">
        <location>
            <position position="472"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="16">
        <location>
            <begin position="580"/>
            <end position="584"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="618"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="16">
        <location>
            <begin position="625"/>
            <end position="627"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="16">
        <location>
            <position position="681"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="707"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="16">
        <location>
            <begin position="713"/>
            <end position="716"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="16">
        <location>
            <position position="789"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR000533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005003068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="837" mass="91640" checksum="D0CBF80044671276" modified="2022-01-19" version="1">MDHQPKFFENLSGSGKAIGVLTSGGDAQGMNAAVRAVVRMGIYVKAKVYFIYEGYQGMVDGGDNIVEVSWESVSSILQIGGTVIGSARCKAFRTRAGRLQAAYNLVRRGITNLCVIGGDGSLTGANLFREEWSGLLEELAQKGKIDEEAVKKYAYLNIVGMVGSIDNDFCGTDMTIGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALACGADWVFIPEYPPEEGWEDTMCVKLSENRARKKRLNIIIVAEGAIDCHNKPITSEKVKDLVVQRLGFDTRVTILGHVQRGGTPSAFDRILASRMGVEAVLALLEGTPDTPACVVSLSGNQSVRLPLMECVQMTQAVQKAMDEGRFDDAVRLRGRSFENNLNTYKLLSQKKPDAELPKSNFNVAVLNVGAPAAGMNAAVRSAVRVGITEGHKMFAVIDGFEGFAKGKIKEINWGDVGGWTGQGGSILGTKRTLPGKFLEKIAEQMRTNNINALMVIGGFEAYLGLLELSAAREKYDEFCVPMVMVPATVSNNVPGSDFSIGADTALNTITDGYESCLQIYEARSRFEEFCVPVCVVPATLSNNMPGSDLSMGGDTALNVIVETCDRIKQSASGTKRRVFIIETMGGYCGYLANMGALAAGADAAYIFEEQFDIRELQANVEHLTEKMKTSIQRGLVLRNENCNENYTTDFIYQLYSEEGKGVFDCRKNVLGHMQQGGAPSPFDRNFGTKISAKAMQWISKKLTETYRKGAGKVFANTEDSVCLLGMRRRNLVFQPVTELKKETDFVHRIPMEQWWLKLRPLMKILAKYKTSYDVSDSGQLEHVAMHSPKEAETGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SSU2</accession>
    <name>A0A8C2SSU2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">tRNA (guanosine(18)-2'-O)-methyltransferase TARBP1</fullName>
            <ecNumber evidence="10">2.1.1.34</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">TAR RNA-binding protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">TARBP1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methylguanosine at position 18 (Gm18) in a subset of tRNA. Selectively mediates Gm18 methylation of tRNAGln-TTG/CTG and tRNASer-TGA/GCT. Gm18 modification can enhance the stability of modified tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>guanosine(18) in tRNA + S-adenosyl-L-methionine = 2'-O-methylguanosine(18) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20077"/>
            <dbReference type="Rhea" id="RHEA-COMP:10190"/>
            <dbReference type="Rhea" id="RHEA-COMP:10192"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74445"/>
            <dbReference type="EC" id="2.1.1.34"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:20078"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer and homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.34" evidence="10"/>
    <dbReference type="Ensembl" id="ENSCJPT00005005914.1">
        <property type="protein sequence ID" value="ENSCJPP00005003293.1"/>
        <property type="gene ID" value="ENSCJPG00005003419.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000003939"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141100">
        <property type="term" value="F:tRNA (guanine(18)-2'-O)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd18091">
        <property type="entry name" value="SpoU-like_TRM3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1280.10:FF:000010">
        <property type="entry name" value="probable methyltransferase TARBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025806">
        <property type="entry name" value="TARBP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056921">
        <property type="entry name" value="TARBP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045330">
        <property type="entry name" value="TRM3/TARBP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044748">
        <property type="entry name" value="Trm3/TARBP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12029:SF11">
        <property type="entry name" value="METHYLTRANSFERASE TARBP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12029">
        <property type="entry name" value="RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25050">
        <property type="entry name" value="TARBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51624">
        <property type="entry name" value="SAM_MT_TRMH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TARBP1" evidence="14">
        <location>
            <begin position="242"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA/rRNA methyltransferase SpoU type" evidence="13">
        <location>
            <begin position="1393"/>
            <end position="1534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00093266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00093361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00093594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00093636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00093656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF25050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005003293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1549" mass="173823" checksum="AA3A609F4E29BBFB" modified="2022-01-19" version="1">MEVVLADALLSRAVDPGAVLRAVCAPLSADGAEALRLLLQRLSAGGARGEAAGEAVRRAAWELALERCRPLLRLGEGAAGGAERLRLCRAVRGALRHCVQLCGAPLAARLARDALDELAGGGTGAEAAVEALAAAAPLLEEPALVGRCAEVALALVREEGEGEAAAALVAGRLLPALGGNGPALGRVWDGLLGRGPAPRVGRALLALSALCDALLPRGPGAAMDARLCPRFWRLVQEGLTERDGLCRKRARYLLKRAVDLSGGQAACMRCPPDGPDGTSLFWWSAEENDKLLQFWETYILIMETLEGNQIHVIKPVLPKLNSLYELAISGKEGCWLFHPSWHMCIYKRMFESENKSLTKEGVLHFLELYETKHLPNSLGFSEFVIGPLMDALSESSLYSRTPSQLMGACPSLGMRLQKFLATYLTLLPEEEKGGFLLKFIQKMTNRHWCAVPILFLSMALAYIPACKVLGTDGLHALRDVLQCTMITHQILLRGAAQCYLLQTAMHLTDVEKVSLPEVASFLLSLRPEESLRRDTVLWMEVRTKATFMFIKRENCFMPDWFEAKLVATMILLAADVEQMRNKSSGKSNIKWIELEAFLNPLLDVLMKLGTNAYIPTLKTDKSLQLLLKLLQTRSLKCSKTQDDEVLSFIRKSLVMPVESVLEFILRRLTTDELSTVGDLDRCDLYLALIPEIVNLCLQLSSKKLPTVKNFISSLTNASIHNFHETDSTEVIQKVTSIASLTVVCELVDQKPEAHLQDLPFVDALKRFTAFSQFNEVLKKPSYIEEKSGTNIPFSCSSVLETSSQGWGRIVARYVRDQWICLRFVLNKFPMLAQKYEEGTSELSSLTAERSREILESALEALTILPSDQVLPVFDCMKVLVPKLLNSLESLCIEAFDLAWKIISSLSNTQLIFWSNLKAFVRFIFDNEVLATAASTKGQAYAKIKEIILKLIDMSTTKTGVFNVVLSHCCQSWILPTCDNRGAVRNAFLNAGDYCELITEGCVFGTVFRRDQRRLIQDVHAFIESLGEKCAANVVTESTNRDDHYVRICAIKFLCLLDGSNILHKSFMEDIVIKLLEKDELVSRTRTRYYANSLQHRIKNRVWQTLLVLLPKLDQNFLCGILDKVFQAGFGNNQASVKYFIEWIIILSLHKYPQFLTKFWDCFCYDEEKLKTSICTFLSVLSHFDTILQNTSEKKPVVKKALLIVLQWCFNHNFSVRLYALVALKKIWAMCRMLDVEEFEALTPVIESSLQQVENMHGTGNARRNWQRIQDHFFFATFHPLEDYSLETIFYTLPRLSEVAEDEWISLCKFERFTDIPLPAAFQWYRSRAELLDLKPSDWSQQDMGSSSVDTDGQTEWTDVQKKIIPWKHSTPSSDLDMVLQDRAAKLGKSNSRLIVVASLIDKPTNLGGLCRTSEIFGASALVVGSLHYIQDKQFQHLSVSAEQWLPLVEVKPSQLVDYLQQKKTEGYTAIGVEQTAKSYDLTEYCFPEKSLLLLGNEHEGIPANLIHHLDVCVEIPQQGIIRSLNVHVSGALLIWEYTRQQVIKHKQQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SSW5</accession>
    <name>A0A8C2SSW5_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="36">Potassium channel subfamily K member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="42" type="primary">KCNK1</name>
    </gene>
    <organism evidence="42 43">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="42" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="42" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="42" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="34">
            <text>Cs(+)(in) = Cs(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:78555"/>
            <dbReference type="ChEBI" id="CHEBI:49547"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>L-glutamate(out) = L-glutamate(in)</text>
            <dbReference type="Rhea" id="RHEA:66336"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="32">
            <text>Li(+)(in) = Li(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:78551"/>
            <dbReference type="ChEBI" id="CHEBI:49713"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NH4(+)(in) = NH4(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:28747"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>Na(+)(in) = Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:34963"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="33">
            <text>Rb(+)(in) = Rb(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:78547"/>
            <dbReference type="ChEBI" id="CHEBI:49847"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>chloride(in) = chloride(out)</text>
            <dbReference type="Rhea" id="RHEA:29823"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="35">Homodimer; disulfide-linked. Heterodimer with KCNK2; disulfide-linked. In astrocytes, forms mostly heterodimeric potassium channels with KCNK2, with only a minor proportion of functional channels containing homodimeric KCNK1. Interacts with KCNK3 and KCNK9, forming functional heterodimeric channels. Interacts with GNG4. Identified in a complex with PSD and ARF6; interacts only with PSD that is bound to ARF6. Interacts with UBE2I.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Apical cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cell projection</location>
            <location evidence="4">Dendrite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cytoplasmic vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Perikaryon</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Recycling endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="28">Synaptic cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 38">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015713370.1">
        <property type="nucleotide sequence ID" value="XM_015857884.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SSW5"/>
    <dbReference type="GlyCosmos" id="A0A8C2SSW5">
        <property type="glycosylation" value="1 site, No reported glycans"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005005929.1">
        <property type="protein sequence ID" value="ENSCJPP00005003308.1"/>
        <property type="gene ID" value="ENSCJPG00005003530.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107311406"/>
    <dbReference type="KEGG" id="cjo:107311406"/>
    <dbReference type="CTD" id="3775"/>
    <dbReference type="GeneTree" id="ENSGT00940000155293"/>
    <dbReference type="OrthoDB" id="297496at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902937">
        <property type="term" value="C:inward rectifier potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043204">
        <property type="term" value="C:perikaryon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097060">
        <property type="term" value="C:synaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005242">
        <property type="term" value="F:inward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005272">
        <property type="term" value="F:sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905030">
        <property type="term" value="F:voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902476">
        <property type="term" value="P:chloride transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014047">
        <property type="term" value="P:glutamate secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060075">
        <property type="term" value="P:regulation of resting membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000076">
        <property type="entry name" value="Potassium channel subfamily K member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003092">
        <property type="entry name" value="2pore_dom_K_chnl_TASK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005408">
        <property type="entry name" value="2pore_dom_K_chnl_TWIK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001779">
        <property type="entry name" value="2pore_dom_K_chnl_TWIK1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF59">
        <property type="entry name" value="POTASSIUM CHANNEL SUBFAMILY K MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038061">
        <property type="entry name" value="K_channel_subfamily_K_type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01096">
        <property type="entry name" value="TWIK1CHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01586">
        <property type="entry name" value="TWIKCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="24" id="KW-0966">Cell projection</keyword>
    <keyword evidence="26" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="22" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0967">Endosome</keyword>
    <keyword evidence="23" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="25 38" id="KW-0407">Ion channel</keyword>
    <keyword evidence="20 36 38" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="21 36 40" id="KW-0472">Membrane</keyword>
    <keyword evidence="17 36" id="KW-0630">Potassium</keyword>
    <keyword evidence="15 36" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="12 36" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="43" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="19" id="KW-0770">Synapse</keyword>
    <keyword evidence="13 38 40" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="18 40" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9 36 38" id="KW-0813">Transport</keyword>
    <keyword evidence="16" id="KW-0832">Ubl conjugation</keyword>
    <feature type="transmembrane region" description="Helical" evidence="40">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="40">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="40">
        <location>
            <begin position="178"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="40">
        <location>
            <begin position="215"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="40">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="41">
        <location>
            <begin position="95"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="41">
        <location>
            <begin position="192"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="39">
        <location>
            <begin position="306"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="39">
        <location>
            <begin position="321"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="37">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00006666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00024167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00034109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00036239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00036683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00044635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="ARBA" id="ARBA00044657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="ARBA" id="ARBA00044691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="35">
        <source>
            <dbReference type="ARBA" id="ARBA00046361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="36">
        <source>
            <dbReference type="PIRNR" id="PIRNR038061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="37">
        <source>
            <dbReference type="PIRSR" id="PIRSR038061-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="38">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="39">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="40">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="41">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="42">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005003308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="43">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="336" mass="38109" checksum="941F7CCF99065584" modified="2022-01-19" version="1">MLQSLAGSSCVRLVEQHRSAWCFALLVLGYLLYLVFGAVVFSSVELPYEDLLRQELGKLKQRFLVEHACLSEQQLEQFLQRVLEASNYGVSVLSNASGNWNWDFTSSLFFASTVLSTTGYGHTVPLSDGGKAFCIIYSVIGIPFTLLFLTAVVQRIIVYVTRRPVLYFHIRWGFSKQIVAIIHAVVLGFITVSCFFFIPAAIFSVLEEDWNFLESFYFCFISLSTIGLGDYVPGEGYNQKFRELYKIGITCYLLLGLIAMLVVLETFCELHELKKFRKLFYVKKDKEEDHVHIMEHDQLSFSSISDQAASMKDDQKANEPFVSSQSPTSNDSSLNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2ST02</accession>
    <name>A0A8C2ST02_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-actin-capping protein subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">CAPZA3</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the F-actin-capping protein alpha subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2ST02"/>
    <dbReference type="Ensembl" id="ENSCJPT00005005012.1">
        <property type="protein sequence ID" value="ENSCJPP00005002694.1"/>
        <property type="gene ID" value="ENSCJPG00005003009.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183119"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030863">
        <property type="term" value="C:cortical cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008290">
        <property type="term" value="C:F-actin capping protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061827">
        <property type="term" value="C:sperm head"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007028">
        <property type="term" value="P:cytoplasm organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007286">
        <property type="term" value="P:spermatid development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.210:FF:000003">
        <property type="entry name" value="F-actin-capping protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.60">
        <property type="entry name" value="F-actin capping protein, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.210">
        <property type="entry name" value="F-actin capping protein, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002189">
        <property type="entry name" value="CapZ_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037282">
        <property type="entry name" value="CapZ_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042276">
        <property type="entry name" value="CapZ_alpha/beta_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042489">
        <property type="entry name" value="CapZ_alpha_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017865">
        <property type="entry name" value="F-actin_cap_asu_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10653">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10653:SF6">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT ALPHA-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01267">
        <property type="entry name" value="F-actin_cap_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00191">
        <property type="entry name" value="FACTINCAPA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90096">
        <property type="entry name" value="Subunits of heterodimeric actin filament capping protein Capz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00749">
        <property type="entry name" value="F_ACTIN_CAPPING_A_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0117">Actin capping</keyword>
    <keyword evidence="3 4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005002694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="287" mass="32937" checksum="8F91835F47B162AC" modified="2022-01-19" version="1">MADYFVGQGLPESEKVSLICRLLHQSPPGEFRQIVQDLCDLLQDDELVKQEAARAGARHNKSNFTPVLVNGSTVLLTQYNDLGGNRFFYPQDKFSFEIDHLSGVTSNTHLHKVMLDEGELWRGALHKGLNVYVNCHFPVGNCCVFKKSLGKSPILVACIEAHQYQPSKHWNSLWKSDWTFALTPFMTRVTGIFVLQLHYFRDANFHVTVKKSVSESLHVIDLNQFVTDFVKFVKAEDNKIHAAILQNIQALSEHAWRKNLRRRLPITRTFMNWNELLNSQHMKTSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2ST64</accession>
    <name>A0A8C2ST64_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2ST64"/>
    <dbReference type="Ensembl" id="ENSCJPT00005006083.1">
        <property type="protein sequence ID" value="ENSCJPP00005003437.1"/>
        <property type="gene ID" value="ENSCJPG00005003614.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000287265"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome Z"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16574">
        <property type="entry name" value="RING-HC_Topors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058746">
        <property type="entry name" value="Znf_RING-type_Topors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46077">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TOPORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46077:SF1">
        <property type="entry name" value="TOP1 BINDING ARGININE_SERINE RICH PROTEIN, E3 UBIQUITIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="64"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="161"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="287"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="471"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="172"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="189"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="246"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="287"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="344"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="379"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="397"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="427"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="481"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="521"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="546"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="561"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005003437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="690" mass="77183" checksum="89193CA13ECEF326" modified="2022-01-19" version="1">FQGQLKSATELISLSLQPPPPCPPSPFQYFINVTGKPVCRGQQLLAQPDNMQAMPANTIPNSKCPICLDTFDNAVYLEPCCHVFCFYCIQRWSRFKTECPVCQQPYFSLYCVDHAESDTSSLSENRAGPSENRYFMSTDQSTASFADSPADLETWERNAKYGSPVPLHDESSISLSEVSSGFSDEGNPQERQWTSSEYSVDLLPQHDETPGPLYSHSEEDGASTVSSTGLEMSHESSARGRATVQSSVNSSNSLSEHCDISGHVNLYTERTPELTELSSDSEVFIREEKREDVKKEQSIQDSSGSDRELSRFSPPLYPHASEYQVKKRLEKSGDISWSDRELSKASSPQSPHTSGYQFKKRQKKSGYSSGSDRKLRRASSPQSPHTSGYQFKKKRVKSGDGSKHQSKESRRSSSCDTCLSLKGHAESSNCESTSSSDSSITWSHCKSYGQSSSSSLDSDWCYRRGYYQNKNRYLLQTPKTAGDDAPCRKRTYSEAHSSQKPTEPEFKSQAFTEGTDLPRSPSEERHNSRYEQRRSKSPSTRSRPRSPSEDTDRRRREKPGGKRKCKTRHLPKRFFSMQASSSACRRSRSEASGVRKPQIRGLSVPFLSFFFPAFVTFLEGSGQSHVNSSEMAIFLEIGPHKKTTLGPLISILSLFRISRTCPSLEQRDFSNLGSCVSQTKGVLEPWPGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2STF0</accession>
    <name>A0A8C2STF0_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="Ensembl" id="ENSCJPT00005003932.1">
        <property type="protein sequence ID" value="ENSCJPP00005002193.1"/>
        <property type="gene ID" value="ENSCJPG00005002361.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005002193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="104" mass="10374" checksum="C2CDB2E7747F5A1A" modified="2025-10-08" version="2">MXXXGGGPCGPYIPNPGGPNDPNPIDPIGPYIPNPGGPHVPSSKGPNDPDPIDPSVPSPIGPNVPSPDPTADPINPEHPHVPNPSQTPHVPSAVGPSAGPHIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SVG5</accession>
    <name>A0A8C2SVG5_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Arylsulfatase family member J</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ARSJ</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015717429.1">
        <property type="nucleotide sequence ID" value="XM_015861943.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SVG5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005006432.1">
        <property type="protein sequence ID" value="ENSCJPP00005003666.1"/>
        <property type="gene ID" value="ENSCJPG00005003806.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005006434.1">
        <property type="protein sequence ID" value="ENSCJPP00005003667.1"/>
        <property type="gene ID" value="ENSCJPG00005003806.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107313582"/>
    <dbReference type="KEGG" id="cjo:107313582"/>
    <dbReference type="CTD" id="79642"/>
    <dbReference type="GeneTree" id="ENSGT00940000159954"/>
    <dbReference type="OrthoDB" id="103349at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16029">
        <property type="entry name" value="4-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1120.10:FF:000002">
        <property type="entry name" value="Arylsulfatase family member J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000007">
        <property type="entry name" value="Arylsulfatase family, member J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047115">
        <property type="entry name" value="ARSB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10342">
        <property type="entry name" value="ARYLSULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10342:SF69">
        <property type="entry name" value="ARYLSULFATASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="9">
        <location>
            <begin position="66"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="521"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="545"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="559"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005003666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="587" mass="65971" checksum="7AC234FE000EC5E9" modified="2022-01-19" version="1">MARGGCSWPQRLRKGKMLAVGVLAGLSVLSLLTYGYLSWDSLGRGPAEAPAALGEERGVGALSSQPHIVFILADDQGFRDVGYHGSEIRTPTLDKLAAEGVKLENYYVQPMCTPSRSQFITGKYQIHTGLQHSIIRPTQPNCLPLDNVTLPQKLKEVGYSTHMVGKWHLGFYRKECMPTQRGFDTFFGSLLGSGDYYTHFKCDSPGICGYDLYENDNAAWDHDNGIYSTQMYTQKVQQILASHDPRKPIFLYIAYQAVHSPLQAPGKYFEHYRSINNINRRRYAAMLACLDEAINNVTLALKKYGYYDNSIIIYSSDNGGQPMAGGSNWPLRGSKGTYWEGGIRAVGFVHSPLLKNKGSVCKELVHITDWFPTLITLAEGQIDEDIQLDGYDIWETISEGRRSPRVDILHNIDPIYTKAKNGSWAAGYGIWNTAIQSAIRVNHWKLLTGNPGYSDWVPPQAFSNVGPNRWHNERVSWSAGKTVWLFNITADPYERVDLSSKYPDVVKQLLRRLSQFNKTAVPVRYPPKDPRSNPKLNGGVWGPWFKEDEKKKKSDKSKGANKQKKNKKKANRKKGQSLHCRSRLAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SVJ7</accession>
    <name>A0A8C2SVJ7_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">XPA, DNA damage recognition and repair factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">XPA</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SVJ7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005006274.1">
        <property type="protein sequence ID" value="ENSCJPP00005003559.1"/>
        <property type="gene ID" value="ENSCJPG00005003712.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000002721"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome Z"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005662">
        <property type="term" value="C:DNA replication factor A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008630">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to DNA damage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035264">
        <property type="term" value="P:multicellular organism growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901255">
        <property type="term" value="P:nucleotide-excision repair involved in interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000715">
        <property type="term" value="P:nucleotide-excision repair, DNA damage recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060261">
        <property type="term" value="P:positive regulation of transcription initiation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034504">
        <property type="term" value="P:protein localization to nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009650">
        <property type="term" value="P:UV protection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21076">
        <property type="entry name" value="DBD_XPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.530.10">
        <property type="entry name" value="XPA C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000465">
        <property type="entry name" value="XPA/RAD14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022656">
        <property type="entry name" value="XPA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022658">
        <property type="entry name" value="XPA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037129">
        <property type="entry name" value="XPA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00598">
        <property type="entry name" value="rad14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10142">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-A CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10142:SF0">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-A CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05181">
        <property type="entry name" value="XPA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <sequence length="301" mass="32442" checksum="13C3136A139BAB1B" modified="2022-01-19" version="1">MSAQSKGTASSSSSPSEGPPAASKAKVKEQIKIIVEDLELVLGDLKDVAKELKEVVDQIDTLTSDLQLEDEMTDSSKTDTLNSSSSSTTASSLEKVKVRGTTPLIKNPVHPSAILTVLRKPNPPPPPPRLTPVKCDKPLRPPPSANPVKTNGTLLRNGPSRIPNGDLCCIPNSNLDNVAIPPLMHRPEKERCPQAGARERVRFSEKVQYHGYCPDCDVRYNIKNREVHLHSEPAHLLGALPHQCPPLPPPPPPLPPFPLENGGLGISSSNSFPPPRPVTVPPQTAPKPQKTILRKSTTTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SZ06</accession>
    <name>A0A8C2SZ06_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Catenin beta 1</fullName>
        </submittedName>
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        <name evidence="7" type="primary">CTNNB1</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
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    <reference evidence="7" key="1">
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                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the beta-catenin family.</text>
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    </dbReference>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_032442400.1"/>
    </dbReference>
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        <property type="gene ID" value="ENSCJPG00005004427.1"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016328">
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031528">
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990909">
        <property type="term" value="C:Wnt signalosome"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0097718">
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0070411">
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0030331">
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0019903">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0003713">
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090425">
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034333">
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                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="3067" mass="341159" checksum="A9AEC5B6445B6EA5" modified="2022-01-19" version="1">MNLHQVLTGAVNPGDNCFSVGSLHDQPFTAYASGCDIVVLGTDFERLQIIPGAKHGNIQVGCVDCSMQQGKIAASYGNVVCIFEPVSLLKQSSRHHNLHYQWQKNAQILLDGIAHNLTWDPTGTRLLTGSSCLQLWSNVPLESSSDNDSTDRTDVGEWRCIWQCNTASQVCLMKFSPDGEFFATAGKDDCLVKVWYNTDNWRSSVTSPSASPGKQAQEVDFSFVYLAHPRSVNSFSWRKTSKFMPRGAVCNVLLTCCKDNVCRLWAETLLPSDSLLYGGGHNNWTEAVNFTNSFKRNTSSKERMQNALELNLRHFRRGRRRSGAVVAHTGCSPHQQDPHEVHRNIAPHANALCHFHIAASINPATDIPLLPSITSLSLGENEEKSGPFVVHWLNNKELHFTLSMEVFLQQLKKNFEHHSPETNTEESSQMDVRSEEETDENGDEQKGNEEKKELGDEKTTPASSLVPLSSAVVDHEVELLLSEWSKNADMLFSIHPMDGSLLVWHVDWLDEYQPGMFRQVQVSFVSRIPVAFPTGDANSLCRSIVMYACTKNVDLAIQQGRQKPPGLTRSSSMLISSGHSKSTNSLKLSIFTPNVMMISKHADGSLNQWLVSFAEESAFSTVISISHKSRYCGHRFHLNDLACHSVLPLLLTTSHHNALSSPDVENAKQANDSLKSQESSVRLQGRGNANVTSQDPNAVYSELILWRVDPVGPLSFSGGVSELARINSLHVSAFSNVAWLPTLIPSYCLGAYCNSPSACFVASDGQHLRLYQAVIDAKKLLCEQSNPEISKYVGEVFNIISQQSTARPGCIIELDHGRKTQLFHVFQEDFILNNQEKGTLDKKNNVADSGKQKNGFSEKFYLIVVEYTQNHSLLHMWHLHLKSVPVSVDSNTPEATTQTEESYSSPDPEKIQSPFTQKYQACRANLQSTSWLTLSSKMVYSQELSLPEGVEIISVKPSAGHLSSSSIYPVCRAPYLLATSCTDGKVRFWRCRVTTESSVSSMPESKVHSDVTYIWEEWPLLIEDGLLSSSAINVPGRPTEVSCAHTNRLAVAYKQVTSKNSHLSQDFVMHVSIFECESTGGSSWVLEQTLHLDEIGTMLDSAVSIDSNLVAYNRQEVSLSCGNVIPSTKHLVHLDWMSREDGSHILTVGIGSKLYMFGQLSGKMQEQNGKETVAISHIGSTTTKATNFSRFVLLRSVDLVSSVEGSPPFPVSLSWVRDGILVVGMDCEMHVYSQWQPPAKQGLVSTDSCSMPSITSLMKESQSAASGLPPPKRTLTRSMTSLAQKLSGKRSAFDLSAEMEDSGLFEAAHMLSPTLPQYHPHQLLELMDLGKVRRTKAILSHLVKCIAGEVVAINESEPNHDRRLRSLTISASGSTSRDPKTFSKTETTDYIEIDSVPPLPLYALLAADDDSSHSCSEKSHSQNSQSKNDMPKDNYEDLFQNSVISTDELVTFDAEEDGEKPKVIDLSQFSPTYFGPEHAQVLSRHLLHSSLPGLTRMEQMSLMALADTIATTSTDIGESRDRSQGGETLDECGLKFLLAVRLHTFLTTSLPPVHRAQLLHQGLSTSHFAWAFHSVAEEELLSMLPAMQKGDPTWSELRAMGVGWWVRNIHSLRKCIEKVAKAAFQRNNDPLDAAIFYLAMKKKAVIWGLYRSQKDTKMTQFFGNNFTEDRWRKAALKNAFSLLGKQRFEHSAAFFLLAGHLKDAVEVCLEKLNDIQLALVISRLYESEFEVSSTYKSVLQKRILGSVFSGKESTGNMYSDPFLRSMGYWILEDYSKALDTLIKHSVEDEEGAGSASCNPAVFNFYNYLRTHPLLLRRHFGSSDASSTHMCLTVENGLADKINLDERRLFFTTAYAHLKAGCPMLALEVLSKMPKVVKRSKPFCRSPSLMDTSKDFSPSSPLKELEIKDESSSIDWSQPTLNDLGSSSDCSSGKHSSSTLSFDWSQPNIIIHDEGLKLQLDSDEGGENEDSSLVMKELKPLKKSEKSYETSSSYTGSFSVVDEKDILSPSEDIISAQLKFRACLKILTVELRTLSTGCEVDGGKLRYQLYQWLEREVIALQKTCDYNVEIDEIPSEISMMPEEVVLHGNTVDLTDQQKNKLQKVNFQKRRQWLLKYQSLLRMFLSYCVLHGSHGGGLASVRMELILLLQESHSPHWVEQSSVPLLFACTASAKTVVANPLLHLGNLTHDILHAIINLDSPPHPDTQNNKIYVMHNLAASLSACIYQCLCDGHSYSSFQANQFTGTVYQTVLLTQRHSLRSTLEETVTPNTSPAQWPGITALVRLLNSAGEEAQPGLTVLLCEILTAVYLSLFIHGLATHSSNELYRIMAHPLNNKMWSAIFGGGAHTPISGQQQLKTKTGRHFPMPSPHQVVVFSMECVGFSKSLTTFSTHSPTKSQCLLSSPLDDGEKQQKRFKPSSKTSLKESSQVPAVPWLDQESPPDKERFIPPELSIWDYFIAKPFLPSQSRAEYDSEESQESDEDDDDIDGDAFAANSHNQEHSNANSYSWSLMRLAMVQLVLNNLKIFYPLAGHDLSELPVSSPVCHAVLKTLQRWEQVLLRRLELYGGPPQHYISVHASEDALAAGPALLRHKTLLEPANTPFRSNSHVALSVKRLWQYLVKQEEVQETFIRNIFTKKRCLNESLEDHNETLKNSVAEEPIINKIETDLGYPGGKARIIHKESDIITAFAVNKANRNCIAIASSHDIQELDVSAILATQIYTWVDDDAEIENKGADDFLVIHARDDLVNVQGTTPYTHSNPGTPINMPWLGSTQTGRGASVMLKKAINNVRRMASHPTLPYYLTGAQDGSVRMFEWGHAQQITCFRSGGNSRVTRMRFNYQGNKFGVVDADGYISLYQTNWKCCPLTGTTPKPYLTWQCHNKTANDFVFISSSSLIATAGLSSDNRNICLWDTLVSPTNSLVHAFVCHDSGATVLAYAPKHQLLISGGRKGFTCIIDLRQKQQQQLLQSHDSQVKAIAVDPTEEFFVTGSAEGNIKVWSLSTFNLLHTFINEHSRQSLFRNIGTGVMQIETGPANHIFSCGADGTVKMRILPDRFSPFNEVLKNDVKFLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T3N2</accession>
    <name>A0A8C2T3N2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zinc finger CCHC domain-containing protein 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">TRAMP-like complex RNA-binding factor ZCCHC7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ZCCHC7</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015705575.1">
        <property type="nucleotide sequence ID" value="XM_015850089.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015705576.1">
        <property type="nucleotide sequence ID" value="XM_015850090.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015705577.1">
        <property type="nucleotide sequence ID" value="XM_015850091.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T3N2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005010521.1">
        <property type="protein sequence ID" value="ENSCJPP00005006729.1"/>
        <property type="gene ID" value="ENSCJPG00005006234.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107306745"/>
    <dbReference type="KEGG" id="cjo:107306745"/>
    <dbReference type="CTD" id="84186"/>
    <dbReference type="GeneTree" id="ENSGT00950000183041"/>
    <dbReference type="OrthoDB" id="7608935at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome Z"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031499">
        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071031">
        <property type="term" value="P:nuclear mRNA surveillance of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071039">
        <property type="term" value="P:nuclear polyadenylation-dependent CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071036">
        <property type="term" value="P:nuclear polyadenylation-dependent snoRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071037">
        <property type="term" value="P:nuclear polyadenylation-dependent snRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.60.10:FF:000020">
        <property type="entry name" value="Zinc finger CCHC domain-containing protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051644">
        <property type="entry name" value="TRAMP_AT-DNA-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46543">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46543:SF1">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="11">
        <location>
            <begin position="268"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="11">
        <location>
            <begin position="376"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="59"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="432"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="110"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="441"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="487"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="502"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="559"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="571" mass="64604" checksum="2CA0C278DEF5B830" modified="2022-01-19" version="1">MFYECEDSEESDAYEDELYREDSSSEPSIDSEVEFHLYSQVHYSQNLSEIGSVEVSEEAEDAVGFTDQSPGLTVTPLEDKNIVELPDPDGQISDDPEIIVLSDTPEEDSVYNSKAQKSTGSLAEGKTRIHGSSKANRSKATEYDAPYPAGSDTEFSGQGPGGKLTSISSGPLSNQEVMVIDDSSDDDEESVISESDDVESWMLLGCSADDKDKDIMLNLEGCATPTEEGDADVDWSISNKDLQAQICNYASVRRAGVRYYTADKNLTCRNCGRPGHLSKNCPIPKKTPPCCLCAERGHLQNTCPARYCLNCCLPGHYFRECLERSYWNKHCSRCDMKGHYADACPEIWRQYHLTTIPGPIKAASSQSEHSAAAVYCYNCSRKGHFGYECTEQRMRGSMFPASPFIHYYDDEYDLKRRANRLKRKIAELQEAGLLPVQPETPRQEGMHGGRSCKKEPWEEHSKRNKDEYHKRKSSSWADKQRAKKHKSDVERGHEMEDDFPRGHHKKTSRGSKKHHKSVLRIHGSKEYSQQLLEAAKRKKKRKKQRDSSPDVNENLFLIKQRRKKSKKSSGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T3Q3</accession>
    <name>A0A8C2T3Q3_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Epoxide hydrolase</fullName>
            <ecNumber evidence="6">3.3.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">EPHX1</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>1-(4-methoxyphenyl)-N-methyl-N-[(3-methyloxetan-3-yl)methyl]methanamine + H2O = 2-{[(4-methoxybenzyl)(methyl)amino]methyl}-2-methylpropane-1,3-diol</text>
            <dbReference type="Rhea" id="RHEA:55764"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:139161"/>
            <dbReference type="ChEBI" id="CHEBI:139164"/>
            <dbReference type="EC" id="3.3.2.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>cis-stilbene oxide + H2O = (1R,2R)-hydrobenzoin</text>
            <dbReference type="Rhea" id="RHEA:23900"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:50004"/>
            <dbReference type="ChEBI" id="CHEBI:50014"/>
            <dbReference type="EC" id="3.3.2.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the peptidase S33 family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_015857238.2"/>
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        <property type="protein sequence ID" value="ENSCJPP00005007212.1"/>
        <property type="gene ID" value="ENSCJPG00005006652.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107311037"/>
    <dbReference type="KEGG" id="cjo:107311037"/>
    <dbReference type="CTD" id="2052"/>
    <dbReference type="GeneTree" id="ENSGT00390000002210"/>
    <dbReference type="OrthoDB" id="7130006at2759"/>
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        <property type="component" value="Chromosome 3"/>
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        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:cis-stilbene-oxide hydrolase activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="P:arachidonate metabolic process"/>
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        <property type="entry name" value="alpha/beta hydrolase"/>
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        <property type="entry name" value="AB_hydrolase_fold"/>
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        <property type="entry name" value="Epox_hydrolase-like"/>
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        <property type="entry name" value="Epoxide_hydro_N"/>
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        <property type="entry name" value="Epoxide_hydrolase"/>
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        <property type="entry name" value="EPOXIDE HYDROLASE 1"/>
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    </dbReference>
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        <property type="entry name" value="EPOXIDE HYDROLASE 1-RELATED"/>
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        <property type="entry name" value="Epoxide_hydrolase"/>
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        <property type="entry name" value="EPOXHYDRLASE"/>
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    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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            <begin position="47"/>
            <end position="156"/>
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            <position position="225"/>
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            <position position="375"/>
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            <position position="432"/>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T4B6</accession>
    <name>A0A8C2T4B6_COTJA</name>
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        <submittedName>
            <fullName evidence="8">PHD finger protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">PHF3</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="protein sequence ID" value="ENSCJPP00005008169.1"/>
        <property type="gene ID" value="ENSCJPG00005007351.1"/>
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        <property type="component" value="Chromosome 3"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:DNA-templated transcription"/>
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        <property type="entry name" value="Znf_PHD"/>
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    </dbReference>
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        <property type="entry name" value="TRANSCRIPTION FACTOR S-II ZINC FINGER DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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    <dbReference type="SUPFAM" id="SSF57903">
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    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
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            <end position="784"/>
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        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005008169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="2069" mass="230665" checksum="13096252FA44487E" modified="2022-01-19" version="1">MIFFLSFYRAERHTGLFMDIVDTFNHLIPTEHLDDALFLGSNLENEVCEDFSTSQNVLEDSLKIMLSDKDPMLGSASAQFCLPVLDSNDPNFQMPCSTVIGLDVIMDEEGVKESGNDAIDEDELTVPNRSLRSRLEETSVASPRKSPRLMAQEPVRSLRQSTLAKRSNIAPVASTKKSSVKSGSAFKTGQKQQEKNPAKEADVATPLKVEQPKEVRRSTRRSGQTEGTVADSQSTKSITGPGEVNEVKSEPLEQAKVEETSQELSSNFGGACTLPKETKEISEIATKAESGNVESVCSADTEITALNDEANDVNDSMGSEASSEEKTENKTVELEKITEEQSGLTGKTNDPSSVGVNQCEIYETFSNLSGSVEDGVECRLGSCSVEVPDENTLLVKECVTEPVDDGKGLEETVTSSEKLMDSTEFDNKDLKSEEFTSVDPGNSILESTVLDHTSQNVQQQIDSTKVEDSDTLKFQVDDDKQFNIPSKCEKNMKPRHSKSVVENKQNVTVSAEQKSSATQQDVKHSRTSLHSSSSASLKRNADEHESHQHPNNPVKIRKKQTDLALKTKSRLTAATVKKQTNAVLKKVPRVQASGLVHKSSIQKAIEKSSQSSSKDTHHPGHPVPGHILNLGQKQAQKHQLASVLKTNSSTKEELEAKDALAVEHLKEDDKEKYKSKRTDKNLQPRQRRSSKSLSLDEPPLFIPDNISTIKREGLEHTPATECKHVWVPNKQCGFCKKPHGNRFMVGCGRCDDWFHGDCVGLSLSQAQQMGEEDKEYVCVKCCAEEDKKAECLDQSVLDTQLKTDSHKEEKTIEHEKPGVSKQGPTCNLNVTTEKGKQTEDTGKHKVKIFKRESGDGKNLSESRDSDTKKGQHVPARKALQTAVIPRRSSEEKGEKMSKESLNVVEKSSKSGVHEKQEIKKKKNEKGPISANVPASKPSADQIRHSVKQSLKEILMKRLTDSSLKIPEERAAKVATKIERELFSYFRDTDSKYKNKYRSLMFNLKDPKNNILFKKVLKGEVTPDHLIKMSPEELASKELAAWRQRENRHTIEMIEKEQREVERRPITKITHKGEIEIESETPMKEQEVMEIQEPNMMKLHEKSEEAEKDKEGNESASPDTTSQHKNHLFDLNCKICIGRMAPPTDDDPSAKKVKVSVGVARKQSDNEAESIADALSSTSSILASELLEDDKQDSSKSSLPTLPKSETPGTVECESLFLARLNFIWKGFINMPSVAKFVIKAYPVSGSFEYLTEDLPDSIQVGGRISPHTVWEYVEKIKASGTKEICVVRFTPVTEEDQISYALLFAYFSSRKRYGVAANNMKQVKDLYLIPLGSSDKVPHHLVPFDGPGIEIHRPNLLLGLIIRQKMKRQISAVTSVTSSFVDEVSESTLSSAPPEKKSKPSKPEVSHNELALEEEEENDFFNSFTTVLHKQRNKPQQSNIEDVPTAIEPLVESTKHEPPKPLRFLPGVLVGWENQPSTLELANKPLPVDDILQSLLGTTGQVCEQSKPEASSGEDIPLLNEQATLKEENMEVDEVTAEVSETKASSDDTQEFTSSTLVPADAALVGSSSSTRNSGTLGLSLKGKPPDVTTEAFIANLSAQSQNKETEESKENDSNLQTPDKDNVTQEIRRTTNSSFSSSNAGKSNENNTNVSSAEGTSGNTSKSPPFINLKRDPRQAAGRNQQTSASENKDGDVSKNEDQQVVSGNDQVEPENKQSAGEIGLNLYPSDAQTDEMQCSSAATKADNVCASQAEDTKQSQEDAMQNIEALNSFRRGPAATSSHFETENSCSEFISKVPSPVTSGSFSSVRLPQQNFQHPKSNPPGFQFQAPTPPNFPPQNSPMFGFPPHLPPQHLPPPGFGFPQNPMVPWPPVDHLSGQPPPYAGPVAQGLPVAQKQSRFLGPENFFQSKDCRRPERRHSDPWGRQEQHLERGFSRGKNDQQRQRFYSDSHHQKKERHEKEWNNEKYWEQDSERNRRRDRNQEKERERKSREEGHRDKERLRLPHSDRGADGKSPRETRNPEKKTEKPKAEEQAQEKDKEREKSKEKHRERESEKSRDRHRDHSDRSKSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T4T3</accession>
    <name>A0A8C2T4T3_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Chloride intracellular channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">CLIC6</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>chloride(in) = chloride(out)</text>
            <dbReference type="Rhea" id="RHEA:29823"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Membrane</location>
            <topology evidence="16">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="16">Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the chloride channel CLIC family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015737579.1">
        <property type="nucleotide sequence ID" value="XM_015882093.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T4T3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005012716.1">
        <property type="protein sequence ID" value="ENSCJPP00005008373.1"/>
        <property type="gene ID" value="ENSCJPG00005007501.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107323225"/>
    <dbReference type="KEGG" id="cjo:107323225"/>
    <dbReference type="CTD" id="54102"/>
    <dbReference type="GeneTree" id="ENSGT00940000159602"/>
    <dbReference type="OrthoDB" id="1935530at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031749">
        <property type="term" value="F:D2 dopamine receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031750">
        <property type="term" value="F:D3 dopamine receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031751">
        <property type="term" value="F:D4 dopamine receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10301">
        <property type="entry name" value="GST_C_CLIC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03061">
        <property type="entry name" value="GST_N_CLIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000001">
        <property type="entry name" value="Chloride intracellular channel 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000021">
        <property type="entry name" value="Chloride intracellular channel 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002946">
        <property type="entry name" value="CLIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053823">
        <property type="entry name" value="CLIC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00862">
        <property type="entry name" value="O-ClC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45476:SF1">
        <property type="entry name" value="CHLORIDE INTRACELLULAR CHANNEL PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45476">
        <property type="entry name" value="CHLORIDE INTRACELLULAR CHANNEL PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22441">
        <property type="entry name" value="CLIC-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01263">
        <property type="entry name" value="INTCLCHANNEL"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13 16" id="KW-0868">Chloride</keyword>
    <keyword evidence="12 16" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="5 16" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14 16" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10 16" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 16" id="KW-0813">Transport</keyword>
    <keyword evidence="7 16" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="domain" description="GST C-terminal" evidence="18">
        <location>
            <begin position="536"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="345"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="17">
        <location>
            <begin position="416"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="451"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00024167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005008373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="707" mass="73558" checksum="BF45E61A0BA87C0E" modified="2022-01-19" version="1">MEESPGQPVGSDEPRGAGEEGAEAVVNPQTSLSPNGAAELSDVSSEGGGGTGGQEAAAVPSEGGDEEPGGAAESPGTGQQEAELPGLGRDGAALHGGEPAAAEGADSEPTGVEPEQTAGKVAPVGTESEEAAVAPAVVEPEELTVTGPSGSDPEGVVQEVNAVGAEPEEAVRDEAPSGTVPEEAPSETVPEEAIREEAPSGAVLEEPAREAPSGTVPEEAVGEEAPSGTVLEEAAIEEAPSRPSPEEVLRNETSSETDPVEAIREEALPGTEPEEAMREEAPSGLRPEEGAREEAPSGTEPEEEMGEEARAGTDPEDAVQEEVPSAPSPEEEAVIVETPSGAELEKEDEEALAGDEEAPQRPGVAEDAVPPPGETDGGQQSPAGPEGDDGAEVLPGAERGAGTGEPAGAGEESAASGGGGAAGRPGGWPGPEGGEWESAGLSLNGVRGPAEDEEDETGSPAALEDEEEKQEYDISLFVKAGSDGESIGNCPFSQRLFMILWLKGVIFNVTTVDLKRKPADLQNLAPGTNPPFMTFDGEVKTDVNKIEEFLEEKLAPPRYPKLAPKHPESNSAGNDVFAKFSAFIKNPRKDANENLEKALLKALRKLDNYLNSPLPDEIDAYSTEEITVSCRKFLDGDELTLADCNLLPKLHIIKVVAKKYRNFDFPPEMTGISRYLSNAYARDEFTNTCPADQEIEYAYLDVAKRMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T5M7</accession>
    <name>A0A8C2T5M7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">General transcription factor IIE subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Transcription initiation factor IIE subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC107313709</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Tetramer of two alpha and two beta chains. Interacts with TAF6/TAFII80. Interacts with ATF7IP. Interacts with SND1. Part of TBP-based Pol II pre-initiation complex (PIC), in which Pol II core assembles with general transcription factors and other specific initiation factors including GTF2E1, GTF2E2, GTF2F1, GTF2F2, TCEA1, ERCC2, ERCC3, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2A1, GTF2A2, GTF2B and TBP; this large multi-subunit PIC complex mediates DNA unwinding and targets Pol II core to the transcription start site where the first phosphodiester bond forms.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIE alpha subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T5M7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005012043.1">
        <property type="protein sequence ID" value="ENSCJPP00005007864.1"/>
        <property type="gene ID" value="ENSCJPG00005007134.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000016696"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005673">
        <property type="term" value="C:transcription factor TFIIE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000087">
        <property type="entry name" value="General transcription factor IIE subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039997">
        <property type="entry name" value="TFE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017919">
        <property type="entry name" value="TFIIE/TFIIEa_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002853">
        <property type="entry name" value="TFIIE_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021600">
        <property type="entry name" value="TFIIE_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024550">
        <property type="entry name" value="TFIIEa/SarR/Rpc3_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097:SF10">
        <property type="entry name" value="HTH TFE_IIEALPHA-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE, ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11521">
        <property type="entry name" value="TFIIE-A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02002">
        <property type="entry name" value="TFIIE_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00531">
        <property type="entry name" value="TFIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51344">
        <property type="entry name" value="HTH_TFE_IIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HTH TFE/IIEalpha-type" evidence="16">
        <location>
            <begin position="14"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="209"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00065242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00073913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00080958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005007864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="426" mass="48440" checksum="F967C28796B8620C" modified="2022-01-19" version="1">MEEQNVTTEVPAALKRLAKYIVRGFYGVEYSLAVDVLTRYPCVKEDDLLELLKYERKQLRTVLNTLKADKFVKMRIRFETGPNGKSTRHNYYYINYKVLVDVTKYKLDHVRRKIEADERDSTTRASFKCPSCSSTYTDLEVNQLFDVFTGTFRCTYCNTEVEEDASALPPHDARTLLAKFNEQMEPIFVLLRETEDTVLPHDLLEPQPTAIPGISESGSGPLASVMSRPEKWATKNSSSGSLYSQHLTIDVQDSEHKKKKKEKATKEQPIWMSESTVEGATTASINNKVLQNACISDNAEQNREKYFTYISLFITLMYCTLLIHESMKSLSSTDYASDVKSKLPESGSDMESENTKCSGTVITKLEGSKLEQEEEQEALDPILMVAGQPYSYSEISENPELVSLMTNEEREAYIKVGQEMFQSVFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T5R4</accession>
    <name>A0A8C2T5R4_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein dispatched homolog 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal. Synergizes with SCUBE2 to cause an increase in SHH secretion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the dispatched family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T5R4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005012074.1">
        <property type="protein sequence ID" value="ENSCJPP00005007877.1"/>
        <property type="gene ID" value="ENSCJPG00005007154.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157407"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904680">
        <property type="term" value="F:peptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007224">
        <property type="term" value="P:smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1640.10:FF:000009">
        <property type="entry name" value="Dispatched homolog 1 (Drosophila)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1640.10:FF:000011">
        <property type="entry name" value="Dispatched RND transporter family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052081">
        <property type="entry name" value="Dispatched_Hh_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45951:SF4">
        <property type="entry name" value="PROTEIN DISPATCHED HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45951">
        <property type="entry name" value="PROTEIN DISPATCHED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034098935" description="Protein dispatched homolog 1" evidence="12">
        <location>
            <begin position="23"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="289"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="411"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="677"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="702"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="731"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="771"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="800"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="13">
        <location>
            <begin position="216"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1127"/>
            <end position="1149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005007877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1235" mass="139672" checksum="3E25FA27D94956D7" modified="2022-01-19" version="1">MLLRNHTVVLIWIFALPVFIQIRSHSQFGDLCQRATAASCCPSWTLGNYIAILNNRSSCQKIVERDVSHTLKLLRTCAKYYYNGTLGPDCWDMNAKRKDQLKCTNVPRKCTKYNAVYQILHYLVDKDFLSPKTADYVLPALKYSMLFSPTEKGESMMSIYLDNFENWNSSDGVTTVTGIEFGIKHSLFQDYLLMDTVYPAIAIVIVLLVMCVYTKSMFITLMTMFAIISSLIVSYFLYRVVFNFEFFPFMNLTALIILVGIGADDAFVLCDVWNYTKFDKPHAGTSETVSITLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVVVLHERYLLNIFSCFKKPQQRVYNNKNCWTVLCQMFHKVIFAVSEASRIFFEKVLPCIVIKFRYIWLFWFLALTVGGAYIVCVNPKMKLPSLELSEFQVFRSSHPFERYDAEYKKLFMFERVHHGEELHMPITVIWGVTPEDNGDPLNPKSKGKLQLDSSFNIASPASQVWILRFCQKLRNQTFFYQTEEQDFTSCFIETFKQWMENQDCDEPSLYPCCSHWSFPYKQEVFELCIKRAIMELERSTGYHLDSKTPGPRFDLNDTIRAVVLEFQSTYLFTLAYEKMHQFYKEVDSWISSELSSAPEGLSNGWFVSNLEFYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIVSIAGTIFVTVGSLVLLGWELNVLESVTISVAVGLSVDFAVHYGVAYRLAPDPDREGKVIFSLSRMGSAIAMAALTTFVAGAMMMPSTVLAYTQLGTFMMLIMCISWAFATFFFQCMCRCLGPQGTCGQIPLPKKLRCNAFSQTFSGAQGSRGQNKSHPISKYQLDSRNQKPEMEHEHYELEPLASQPGICNPTEKVTYEETHICSELFSSRPQNTCMPMHSVYNSEVSKSIKNVASSAVLQSSIDQHALCPLFSQNRQCSCPDPYKQVTVKWSPHSCQQLSDPFCYQCSPSPGAMQIQSSVTPINTLQQTAEGYVHPVQHVLHCNCLQGRLKRTMTQNSLPKNFFLQSVQQFQAHQRVNRTDSHTHQNPEENIRMVPKVMSSSQFLCRNVGPLIVHCSECENSISNNQKGLCQKADKCDEKGGTEANGVESKKASMSKQKKKAESKIDQCSLQNDQVLKGDKAANKHLLNRSAGEAHCEGRHENSHCCSMAVAVKCNSVDCQMPNIEANVPPMLMRPELSNESLLIKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T680</accession>
    <name>A0A8C2T680_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Zinc finger protein 777</fullName>
        </submittedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T680"/>
    <dbReference type="Ensembl" id="ENSCJPT00005013655.1">
        <property type="protein sequence ID" value="ENSCJPP00005009112.1"/>
        <property type="gene ID" value="ENSCJPG00005008061.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155153"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000065">
        <property type="entry name" value="B-cell CLL/lymphoma 6, member B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001158">
        <property type="entry name" value="zinc finger protein 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000540">
        <property type="entry name" value="zinc finger protein 263 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000410">
        <property type="entry name" value="Zinc finger protein 777"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000617">
        <property type="entry name" value="Zinc finger protein 777"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KRAB" evidence="17">
        <location>
            <begin position="130"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="281"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="331"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="359"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="389"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="417"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="445"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="473"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="501"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="302"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005009112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="526" mass="58759" checksum="198E498839962661" modified="2022-01-19" version="1">MAEGAPAQVRARPGLGGGRRAAQTQTAELSLTVVAAVQAVERKVDSHATRLLDLEGRTGVAEKKLIDCEKTAAELGNQLESKCAALGTLIQEYGLLQRRLENMENLLKNRNFWILRLPPGRKGEVPKVPVTFDDVSVCFNDKEWEKLEGWQKELYKNVMKGNYESLISLGKSGRYFPAVHLLQVLGILLLPPEGPKWVPGSGQRVLRGSGGSGALCAAFTVRLGGGQGHSLHLGGGHSSGESPVGGSQGLLGALRMTAGCISPCCSWDQSRDQNGGAEGPYECHECDLSFRNKQQFLLHQRSHTRRAVGVPRRPEHGLKAPTRPPAPGKPYKCSECESSFSHKSSLSKHQITHVGERPFTCGECRRSFRLQISLIMHQRIHAGKNEMAFLCPQCGKNFTRPSHLLRHQRTHTGERPYQCSQCDKTFSEKSKLTNHYRIHTRERPHACAVCGKGFIRKHHLLEHQRIHTGERPYHCTECGKNFTQKHHLLEHQRAHTGERPYPCTECTKCFRYKQSLKYHLRTHVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T6L3</accession>
    <name>A0A8C2T6L3_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Piezo type mechanosensitive ion channel component 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">PIEZO2</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PIEZO (TC 1.A.75) family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSCJPT00005013868.1">
        <property type="protein sequence ID" value="ENSCJPP00005009271.1"/>
        <property type="gene ID" value="ENSCJPG00005007948.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154456"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027272">
        <property type="entry name" value="Piezo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031334">
        <property type="entry name" value="Piezo_cap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056770">
        <property type="entry name" value="Piezo_THU9_anchor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056769">
        <property type="entry name" value="Piezo_TM1-24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031805">
        <property type="entry name" value="Piezo_TM25-28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056768">
        <property type="entry name" value="THU_Piezo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47049:SF6">
        <property type="entry name" value="PIEZO-TYPE MECHANOSENSITIVE ION CHANNEL COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47049">
        <property type="entry name" value="PIEZO-TYPE MECHANOSENSITIVE ION CHANNEL HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12166">
        <property type="entry name" value="Piezo_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24874">
        <property type="entry name" value="Piezo_THU9_anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24871">
        <property type="entry name" value="Piezo_TM1-24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15917">
        <property type="entry name" value="Piezo_TM25-28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23188">
        <property type="entry name" value="THU_Piezo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="266"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="502"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="532"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="570"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="654"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="680"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="711"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="763"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T950</accession>
    <name>A0A8C2T950_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ALK and LTK ligand 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ALKAL2</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ALKAL family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015714795.1">
        <property type="nucleotide sequence ID" value="XM_015859309.2"/>
    </dbReference>
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    <dbReference type="Ensembl" id="ENSCJPT00005013910.1">
        <property type="protein sequence ID" value="ENSCJPP00005009306.1"/>
        <property type="gene ID" value="ENSCJPG00005008184.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005013912.1">
        <property type="protein sequence ID" value="ENSCJPP00005009308.1"/>
        <property type="gene ID" value="ENSCJPG00005008184.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107312147"/>
    <dbReference type="KEGG" id="cjo:107312147"/>
    <dbReference type="CTD" id="285016"/>
    <dbReference type="GeneTree" id="ENSGT00940000162505"/>
    <dbReference type="OrthoDB" id="9807651at2759"/>
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        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030298">
        <property type="term" value="F:receptor signaling protein tyrosine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030971">
        <property type="term" value="F:receptor tyrosine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030297">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070374">
        <property type="term" value="P:positive regulation of ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070378">
        <property type="term" value="P:positive regulation of ERK5 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010976">
        <property type="term" value="P:positive regulation of neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029364">
        <property type="entry name" value="ALKL1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28676:SF2">
        <property type="entry name" value="ALK AND LTK LIGAND 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28676">
        <property type="entry name" value="ALK AND LTK LIGAND 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15129">
        <property type="entry name" value="ALKL1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0202">Cytokine</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044679382" evidence="10">
        <location>
            <begin position="23"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005009306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="152" mass="17694" checksum="F34A86E0327E3423" modified="2022-01-19" version="1">MSGLRSPGLLGLVLLVLSAGYCKEKTDGADLKDRQSLLNLIMEIIQELKRYRLEKDSGVQYFSKHDYSLDRREVADYGGYQDEQRVEIVPRDLRMKDKFLKHLTGPLYFSPKCSKHFHRLYHNTRDCTIPAYYKRCARLLTRLAVSPMCMEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T990</accession>
    <name>A0A8C2T990_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcriptional activator Myb</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">MYB</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T990"/>
    <dbReference type="Ensembl" id="ENSCJPT00005015079.1">
        <property type="protein sequence ID" value="ENSCJPP00005010137.1"/>
        <property type="gene ID" value="ENSCJPG00005008875.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156248"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071987">
        <property type="term" value="F:WD40-repeat domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030183">
        <property type="term" value="P:B cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006816">
        <property type="term" value="P:calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071354">
        <property type="term" value="P:cellular response to interleukin-6"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990830">
        <property type="term" value="P:cellular response to leukemia inhibitory factor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048566">
        <property type="term" value="P:embryonic digestive tract development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030218">
        <property type="term" value="P:erythrocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901533">
        <property type="term" value="P:negative regulation of hematopoietic progenitor cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045653">
        <property type="term" value="P:negative regulation of megakaryocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902895">
        <property type="term" value="P:positive regulation of miRNA transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048536">
        <property type="term" value="P:spleen development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017145">
        <property type="term" value="P:stem cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045064">
        <property type="term" value="P:T-helper 2 cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048538">
        <property type="term" value="P:thymus development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000010">
        <property type="entry name" value="Transcriptional activator Myb isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000016">
        <property type="entry name" value="Transcriptional activator Myb isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000042">
        <property type="entry name" value="Transcriptional activator Myb isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015395">
        <property type="entry name" value="C-myb_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050560">
        <property type="entry name" value="MYB_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012642">
        <property type="entry name" value="Tscrpt_reg_Wos2-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614">
        <property type="entry name" value="MYB PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614:SF5">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09316">
        <property type="entry name" value="Cmyb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07988">
        <property type="entry name" value="LMSTEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH myb-type" evidence="12">
        <location>
            <begin position="15"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="11">
        <location>
            <begin position="15"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="12">
        <location>
            <begin position="67"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="11">
        <location>
            <begin position="67"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="11">
        <location>
            <begin position="119"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="12">
        <location>
            <begin position="123"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="416"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="467"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="537"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="430"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="484"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="498"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="537"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00093768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00093793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005010137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="741" mass="82132" checksum="48106D5A31DFDFC9" modified="2022-01-19" version="1">MYDHDYDGLLPKAGKRHLGKTRWTREEDEKLKKLVEQNGTEDWKVIASFLPNRTDVQCQHRWQKVLNPELIKGPWTKEEDQRVIELVQKYGPKRWSVIAKHLKGRIGKQCRERWHNHLNPEVKKTSWTEEEDRIIYQAHKRLGNRWAEIAKLLPGRTDNAIKNHWNSTMRRKVEQEGYLQESSKAGLPSAATGFQKSSHLMTFAHNSPAGPLPGAGQAPLGSDYPYYHITEPQNVPGQIPYPVALHVNIVNVPQPAAAAIQRHYNDEDPEKEKRIKELELLLMSTENELKGQQALPTQNHTANYPGWHSTTVADNTRTSGDNAPVSCLGEHHHCTPSPPVDHGCLPEESASPARCMIVHQSNILDNVKNLLEFAETLQLIDSDPSSWGDLSSFEFFEDADILAGKATSGRAVQLQHGGASACGPPGHPISNLSKTMSSQGPPGSPKSLSASQGSAAPWVLRKRRGHVSPLASGPSSTLGLADGSSSTSKHSPVKSLPFSPSQFLNTSSNHENPNLDNPALTSTPVCGHKMAVTTPFHRDQTFKTQKENHVFRTPAIKRSILESSPRTPTPFKNALAAQEIKYGPLKMLPQTPTHLVEDLQDVIKQESEESAIVAGLHESGPPLLKKIKQEVESPTDKAGNFFCSNHWEGENLNTQLFTHASTMEDVPNLLTSSILKMPASEEEGSFHKTFGIPRNRPLASPLQHLNNAWESASCGKTEDQMALTDQARKYMAAFPTRTLVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T9B2</accession>
    <name>A0A8C2T9B2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome biogenesis protein BOP1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Block of proliferation 1 protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">BOP1</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the PeBoW complex, composed of BOP1, PES1 and WDR12. Within the PeBoW complex BOP1 interacts directly with PES1 and WDR12. The PeBoW complex also associates with the 66S pre-ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat BOP1/ERB1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T9B2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005014075.1">
        <property type="protein sequence ID" value="ENSCJPP00005009413.1"/>
        <property type="gene ID" value="ENSCJPG00005008168.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000018422"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008283">
        <property type="term" value="P:cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0000448">
        <property type="term" value="P:cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:1901796">
        <property type="term" value="P:regulation of signal transduction by p53 class mediator"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000576">
        <property type="entry name" value="Ribosome biogenesis protein ERB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03027">
        <property type="entry name" value="BOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028598">
        <property type="entry name" value="BOP1/Erb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012953">
        <property type="entry name" value="BOP1_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17605:SF0">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17605">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BOP1 BLOCK OF PROLIFERATION 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08145">
        <property type="entry name" value="BOP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM01035">
        <property type="entry name" value="BOP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BOP1 N-terminal" evidence="8">
        <location>
            <begin position="119"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="60"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005009413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="655" mass="74760" checksum="916DA07291094D90" modified="2022-01-19" version="1">MSGFWACGAGFGPHRYRPDPARPPLVQPLELQSDEELTDSEESVYSGLEDSGSDSTNSSDQEEEEDEEDEEESEEPGNGADPQVRSGDGGRLVPDEYEEDSSDEEDIRNTVGNIPMEWYQDFPHIGYDLEGKRIYKPIRNKDELDKFLEKMENPDYWRTVQDKMTGADIKLTDEQVELVHRLQRGQFGDVHFNPYEPAIDFFTHEVMIHPVTNRPADKRSFIPSLVEKEKVSRLVHAIKMGWIKPRRPKEETPTYYDLWAHEDPNSILGRHKMHVPAPKMKLPGHEESYNPPPEYLLSEEEKLAWEQQDPVDRRLSFIPQQFRCLRAVPAYPRFIHERFERCLDLYLCPRQRKMRVNVDPEDLIPKLPKPRDLQPFPTTQALVYRGHSSLVRCISVSPSGQWLASGTAPLRASHPNTLSAAPAPGLCTGDGLVVGLKNLSGLLQALKQVTWHGKGDYFATVVADNSSMQVLIHQTSKRWSQNPFRKSKGLVQCVLFHPIRPYFFVATQRYVRIYNLLKQELTKKLMANCKWVSSMAIHPAGDNVICGSYDSKLAWFDLDLSTRPYQLLRHHRRALRSVAFHKHYPLFASGSDDGTVIVCHGMVYNDLLQNPLLVPVKVLKGHALTMDLGVLDVVFHPTQPWVFSSGADGTIRLYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T9Z2</accession>
    <name>A0A8C2T9Z2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA endonuclease RBBP8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">RBBP8</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the COM1/SAE2/CtIP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015710885.1">
        <property type="nucleotide sequence ID" value="XM_015855399.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015710886.1">
        <property type="nucleotide sequence ID" value="XM_015855400.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015710887.1">
        <property type="nucleotide sequence ID" value="XM_015855401.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015710888.1">
        <property type="nucleotide sequence ID" value="XM_015855402.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032298582.1">
        <property type="nucleotide sequence ID" value="XM_032442691.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032298583.1">
        <property type="nucleotide sequence ID" value="XM_032442692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T9Z2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005015771.1">
        <property type="protein sequence ID" value="ENSCJPP00005010684.1"/>
        <property type="gene ID" value="ENSCJPG00005009274.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107310081"/>
    <dbReference type="KEGG" id="cjo:107310081"/>
    <dbReference type="CTD" id="5932"/>
    <dbReference type="GeneTree" id="ENSGT00530000063835"/>
    <dbReference type="OrthoDB" id="5801062at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070533">
        <property type="term" value="C:BRCA1-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017053">
        <property type="term" value="C:transcription repressor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061629">
        <property type="term" value="F:RNA polymerase II-specific DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010792">
        <property type="term" value="P:DNA double-strand break processing involved in repair via single-strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110025">
        <property type="term" value="P:DNA strand resection involved in replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019518">
        <property type="entry name" value="CtIP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013882">
        <property type="entry name" value="Ctp1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033316">
        <property type="entry name" value="RBBP8-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15107:SF4">
        <property type="entry name" value="DNA ENDONUCLEASE RBBP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15107">
        <property type="entry name" value="RETINOBLASTOMA BINDING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10482">
        <property type="entry name" value="CtIP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08573">
        <property type="entry name" value="SAE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="19" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="14 20" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="18" id="KW-0469">Meiosis</keyword>
    <keyword evidence="11" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DNA endonuclease Ctp1 N-terminal" evidence="23">
        <location>
            <begin position="21"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="DNA endonuclease activator Ctp1 C-terminal" evidence="22">
        <location>
            <begin position="841"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="269"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="609"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="891"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="29"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="111"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="271"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="291"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="309"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF08573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF10482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005010684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="912" mass="103542" checksum="B7C20EB366F739EA" modified="2022-01-19" version="1">MNASGGTCGSPSSAEPAGDFFKELWSKLKECHDKEVQGLQLKISKLKKERCLDAERLEEFYTKNQQLREQQKALHDTIKVLEDRLRAGLCDRCAVTEEHMRKKQLEFENIRQQNLKLITELMNEKNSLQDENKKISEQFQQLQKELEEQKQQALDVEEGVIPDSPVLTSSFSMINRMRRKKENRHIRYTEHTHPDLELAKSNSEFQIPLYSTQASSHHEEEMLVADTCDPQLSPVPNKPRMGGYPVTKPSFNLAAVVAETIGLAVQDESESQSVLSSPHASTAMNQAPEGIRSEDSRKHSAPESRNEDNSLGFSGPSQNTPPRVDWDSQVVSPVFGASSNTRSNSSTSHASCILDSDSKHNVKINLFNHPSGSRSHKNRSKSEDVAFVAPLNLGTEINSVISQVSVNRQMVVKKNNNEVATSVGNTCAAKNEVIKSDFLLIHQKQPEGRCAKRKKAEDENEISCEKASFNKENSVPFLSDIQHVNGEHTGDKPLDLSDRFCGVRCQEKKQGNEETCKNKLKQVTLYDVFLQLGKPNHEGSSSVQNANNERSLFGRGMQEEPYIQEAVLAKTFADTKKQIQMKEEVPPLKITPLPSTVDTEQLFNDVKVASDHVPNRKKTRTGHGESEPASVLQPNPCRLSKNKVQPNEQDLKEKPLENLQWSIDPGADLAQYKMDVTVIDTKDDSQSRIGGEVVDMDYTYVSESVLLKMKNQEQTQESSPRREKKMNDTITEMFDRTADEEYESCLPEDSLSACDEKETVHGEELDRGITVANKKLKKHEDKQDKAKQKAFVEPYFKSDERKNTMLDFPHIEVIRNKEERRKLQGHTCKECEIYYADIPEEEREKKLAACSRHRFRYIPPNTPENFWEVGFPSTQTCMERGYIKEDVAPCQRPKRRQPYAVTFSPKGKEQKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TAV9</accession>
    <name>A0A8C2TAV9_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Histone deacetylase 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">HDAC10</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histone deacetylase family. HD type 2 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015708036.1">
        <property type="nucleotide sequence ID" value="XM_015852550.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TAV9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005014546.1">
        <property type="protein sequence ID" value="ENSCJPP00005009779.1"/>
        <property type="gene ID" value="ENSCJPG00005008558.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107308576"/>
    <dbReference type="KEGG" id="cjo:107308576"/>
    <dbReference type="CTD" id="83933"/>
    <dbReference type="GeneTree" id="ENSGT00940000160061"/>
    <dbReference type="OrthoDB" id="424012at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004407">
        <property type="term" value="F:histone deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042826">
        <property type="term" value="F:histone deacetylase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035825">
        <property type="term" value="P:homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032425">
        <property type="term" value="P:positive regulation of mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106048">
        <property type="term" value="P:spermidine deacetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd11683">
        <property type="entry name" value="HDAC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000005">
        <property type="entry name" value="histone deacetylase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF43">
        <property type="entry name" value="POLYAMINE DEACETYLASE HDAC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="5">
        <location>
            <begin position="28"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005009779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="681" mass="75804" checksum="30521B80DE734D37" modified="2022-01-19" version="1">MASGTALIYDEAMTRHKLLWNDPVCDIEVPERLSASYEQLQRYHLVERCVPVPAREGSEEEILLVHSSEHLEVAKSTQTMNEEELKRISGNYDAFFFHPNTYHCARLAVGAALQLVDSVMSGKVCNGMALVRPPGHHSQRNAANGFCLFNNVAIAAEYAKLKYGLKRILIVDWDVHHGQGIQYIFEEDPSVLYFSWHRYEHQKFWPSLKESDYDAVGLGKGKGFNINLPWNKVGMGNSDYLAAFFHVLLPVAFEFDPELVLVSSGYDSGIGDPEGQMNATPEVFAHLTHFLMHLAHGKLCVILEGGYHLKSLSESVCTTVKTLLRDPVPQLTGEMAPCLSAIESIQNVRAAHKPYWKWLMYEDTPFLYNLSTKSDLPGTADTNPSTDDEAKITDSKETDKIERFLESHMKNVIFPDPPIKTAITAGLKASADLNTFPVHLHVVEEMDKNEVKALVSDFHPDLVKANKTLLSLGSTLTILDKILKKEVCNGIAESPAASASVAVALRRSLHFGFQRMLCIFVGDMHIIPNTEDGKVLVIHVCKNEQPGKSSSKHYIVLNWKEDADRNDFYSAVLGFILPIAYSYQPNLIVIAIGPNRSLGISGISLLFGLLQGLAESRILAVIEDTDINLMQSVAKTLAGASMPHFGVHVPPTQEKVNQIKMLRKQLQQDWKMLQCSVNDGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TAW6</accession>
    <name>A0A8C2TAW6_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cyclin G1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">CCNG1</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TAW6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005014875.1">
        <property type="protein sequence ID" value="ENSCJPP00005009990.1"/>
        <property type="gene ID" value="ENSCJPG00005008749.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154726"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="CDD" id="cd20583">
        <property type="entry name" value="CYCLIN_CCNG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000006">
        <property type="entry name" value="Cyclin I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0195">Cyclin</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="4">
        <location>
            <begin position="96"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005009990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="334" mass="38061" checksum="69E7D612014B04EE" modified="2022-01-19" version="1">MSCAGGACAAPSGPGWFGVVSVCVCVCVWGCVGTCFFLQMIETLVSSDARALLYQLTALLEQEVRCQPKGSGLRLIEAAHDNGLRMTARLRDFEVKDLLSLTQFFGFHTETFSLAVNFLDRFLSKMKVQPKHLGCVGLSCFYLAVKATEEERNVPLATDLIRISQYRFTVSDMMRMEKIVLEKLSWKVKATTAFQFLQLYHSLIHENLSCERKRYLNFERLETQLKACHCRIMFSKAKPSVLALSILALEIEEQKLLELTEALEFLQLQSKINNRDLTFWKELVLKCLTEYSSSKCSKPNVQKLKWIVSGRTARQLKHSYYRITHLPTIPETSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TBW8</accession>
    <name>A0A8C2TBW8_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TBW8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005016555.1">
        <property type="protein sequence ID" value="ENSCJPP00005011314.1"/>
        <property type="gene ID" value="ENSCJPG00005009719.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005011314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="277" mass="29123" checksum="B942D29434266B5A" modified="2022-01-19" version="1">MGLSSTRGCWAHLEDAGSIRGAPGVEQVVLPRAHKPLPCGRRQSSRVGPLVHGGLGAAGTPQRERPKGSSAARTAGGELEGEDAALVQVQLVLVGLGVVHAEGVGALHAQRGPQAQGCRERWCQRMWWWVWGCARCPAMLTQGVHRGFGGSGAELWGTAGSRGYGIALRCGGAGLEAGCPRLLHLLGQNNVTLPSSTHHPQVLPPSLNPARYKGSPPDLQPSSFPLCGAERRRLLPAQWQLLQPVLTGGIGMDTVWGRGVLRGRDNSRAGMGGITPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TBX8</accession>
    <name>A0A8C2TBX8_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Solute carrier family 6 member 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">SLC6A9</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TBX8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005016567.1">
        <property type="protein sequence ID" value="ENSCJPP00005011326.1"/>
        <property type="gene ID" value="ENSCJPG00005009726.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157263"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016328">
        <property type="term" value="C:lateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015375">
        <property type="term" value="F:glycine:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903804">
        <property type="term" value="P:glycine import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061537">
        <property type="term" value="P:glycine secretion, neurotransmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001504">
        <property type="term" value="P:neurotransmitter uptake"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070455">
        <property type="term" value="P:positive regulation of heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046985">
        <property type="term" value="P:positive regulation of hemoglobin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060092">
        <property type="term" value="P:regulation of synaptic transmission, glycinergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd11498">
        <property type="entry name" value="SLC6sbd_GlyT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF263">
        <property type="entry name" value="SODIUM- AND CHLORIDE-DEPENDENT GLYCINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00754">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="361"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="462"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="495"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="542"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="571"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="630"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="672"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="704"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="744"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="779"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="211"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="846"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="872"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="545"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="577"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="642"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
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        <location>
            <begin position="400"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005011326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="886" mass="96459" checksum="D830D27BF098E9A5" modified="2022-01-19" version="1">MGTHFLCCPLCCHCPQCELALSQPAQSSHSCTPSLCPPPPPIQHPMIRNTGLRGCPSRTGWQLLQNTFPGVGEASVCCHHCTPLPSWGSHLVAQPRGSVGPLQPWAVATQRGPSCQARGVGELEQRSLCAQAPEPALYDLQALPSLQPGSGESYSSGLAWGRGGFPPAPWHCACMVGGCRHRAAHAGDGWGRMQGATQPLSAAVTPPMGPVRVPSPAEAPHGISPQNGAVPGERSKQDKSVKRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGGCYGEMGFGGPKGAGAAELCWGVQGAACSHCGLCLPGAFMFPYFIMLVFCGIPLFFMELSFGQFASQGCLGVWRVSPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFVSMTRVLPWTYCSNAWNTPDCVGVLDGNLSSHAAVNLTRLFNATQKRTSPSKEYWRRYVLNLSDDIGNLGEVRLPLLGCLGVSWVVVFLCLIKGVKSSGKVVYFTATFPYVVLTILFVRGITLEGALTGIMYYLTPQWDKILDAKVWGDAASQIFYSLGIGFGGLLSMASYNKFHNNCYRDSIIISITNCATSFFAGFVIFSVLGFMANHLGVDISKVADHGPGLAFVAYPEALTLLPISPLWSILFFFMLILLGLGTQFCLLETLVTAIVDEVGNEWIIRRKTFVTLGVAVAGFLLGIPLTTQAGIYWLLLMDNYAASFSLVVISCIMCVAIMYIYGHRNYFKDIEMMLGFPPPLFFQICWRFISPAIIFFILVFTVIQYRPISYNEYVYPTWAISIGFLMALSSVICIPIYAIYKVCHSEGDTLLERLKNATKASKDWGPALAEHRSGRYAPVFSPSTESHLEVQPLHPEKARNEAVAASPAQGSNGSAHSQDSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TEW9</accession>
    <name>A0A8C2TEW9_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Heteroous nuclear ribonucleoprotein D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">HNRNPD</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TEW9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005017103.1">
        <property type="protein sequence ID" value="ENSCJPP00005011729.1"/>
        <property type="gene ID" value="ENSCJPG00005010050.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158010"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106002">
        <property type="term" value="C:mCRD-mediated mRNA stability complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097167">
        <property type="term" value="P:circadian regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070934">
        <property type="term" value="P:CRD-mediated mRNA stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900152">
        <property type="term" value="P:negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000767">
        <property type="term" value="P:positive regulation of cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904355">
        <property type="term" value="P:positive regulation of telomere capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032212">
        <property type="term" value="P:positive regulation of telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042752">
        <property type="term" value="P:regulation of circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd12756">
        <property type="entry name" value="RRM1_hnRNPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12583">
        <property type="entry name" value="RRM2_hnRNPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000030">
        <property type="entry name" value="Heterogeneous nuclear ribonucleoprotein d0 isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000156">
        <property type="entry name" value="Heterogeneous nuclear ribonucleoprotein d0 isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48033:SF3">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN D0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48033">
        <property type="entry name" value="RNA-BINDING (RRM/RBD/RNP MOTIFS) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="84"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005011729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="257" mass="29341" checksum="30E114DCD5BF8ABB" modified="2022-01-19" version="1">MFIGGLSWDTTKKDLKDYFSKFGEVVDCTLKLDPITGRSRGFGFVLFKESESVDKVMDQKEHKLNGKVIDPKRAKAMKTKEPVKKIFVGGLSPDTPEEKIREYFGAFGEVDSIELPMDNKTNKRRGFCFITFKEEEPVKKIMEKKYHNVGLSKCEIKVAMSKEQYQQQQQWGSRGGFVGRARGRGGGPSQNWNQGYSNYWNQGYGNYGYNSQGYGGYGGYDYTGYNNYYGYSDYSNQQSGYGKVSRRGGHQNSYKPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TEX5</accession>
    <name>A0A8C2TEX5_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteasome subunit alpha type-5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PSMA5</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7. PSMA5 interacts directly with the PSMG1-PSMG2 heterodimer which promotes 20S proteasome assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TEX5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005015510.1">
        <property type="protein sequence ID" value="ENSCJPP00005010491.1"/>
        <property type="gene ID" value="ENSCJPG00005009127.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00550000074958"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03753">
        <property type="entry name" value="proteasome_alpha_type_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000019">
        <property type="entry name" value="Proteasome subunit alpha type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033812">
        <property type="entry name" value="Proteasome_alpha_type_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6 9" id="KW-0647">Proteasome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="10">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00062795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005010491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="541" mass="57764" checksum="3032E62A0E888F07" modified="2022-01-19" version="1">MGPCIPMGPCISMGSFDPMGPCVPMGHCIPVEPCIPMGPCIPMGPCIPMGPCDPIGPCDPMGSLCPYGALYPYWACVPMGLLCPYGGPVTLWGPVSLWGPVSLWDLCVPMGPCEPMGPLCPYGALYPYGTFVSLWGPCVPMGSCDPMAPVSLWGPCDPMGAPVTLWGLPSCGTAGCIKPSVGLMCGDGALGVSNFWVLGMALGVLCYLLLKSLPPSAGGFAAWGLYPRPYCAMRTTVPPAQCCLLLHPQLNIAGVRGLNPSCVLCQLDFLSASICFSCHLCSYRGVNTFSPEGRLFQVEYAIEAIKLGSTAIGIQTSEGVCLAVEKRITSPLMEPSSIEKIVEIDSHIGCAMSGLIADAKTLIDKARVETQNHWFTYNETMTVESVTQAVSNLALQFGEEDADPGAMSRPFGVALLFGGVDEKGPQLFHMDPSGTFVQCDARAIGSASEGAQSSLQEVYHKSMTLKEAIKSSLVILKQVMEEKLNATNIEARRCQTFENHVVLTLLLLFSHCCPPNTRIPFPKQPSSVHPFVLINCCWRLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TG76</accession>
    <name>A0A8C2TG76_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pancreatic secretory trypsin inhibitor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC107320453</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TG76"/>
    <dbReference type="Ensembl" id="ENSCJPT00005019130.1">
        <property type="protein sequence ID" value="ENSCJPP00005013294.1"/>
        <property type="gene ID" value="ENSCJPG00005011229.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00930000151769"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01327">
        <property type="entry name" value="KAZAL_PSTI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21312:SF28">
        <property type="entry name" value="OVOINHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21312">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00050">
        <property type="entry name" value="Kazal_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00282">
        <property type="entry name" value="KAZAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0722">Serine protease inhibitor</keyword>
    <feature type="domain" description="Kazal-like" evidence="6">
        <location>
            <begin position="8"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005013294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="73" mass="7934" checksum="7BDC2A58EC949DF4" modified="2022-01-19" version="1">EPDGAGDQGTEAACGNYDIRKGCTKNFDPICGTDNVLYGNECLLCVQNMQRHTNVRIKNRGKCQEPSPRSSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TGE1</accession>
    <name>A0A8C2TGE1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondria-eating protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Spermatogenesis-associated protein 18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">SPATA18</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MIEAP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TGE1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005018218.1">
        <property type="protein sequence ID" value="ENSCJPP00005012591.1"/>
        <property type="gene ID" value="ENSCJPG00005010710.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000013532"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901612">
        <property type="term" value="F:cardiolipin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140693">
        <property type="term" value="F:molecular condensate scaffold activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035965">
        <property type="term" value="P:cardiolipin acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035694">
        <property type="term" value="P:mitochondrial protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035695">
        <property type="term" value="P:mitophagy by internal vacuole formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900210">
        <property type="term" value="P:positive regulation of cardiolipin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026169">
        <property type="entry name" value="MIEAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031981">
        <property type="entry name" value="MIEAP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21771:SF0">
        <property type="entry name" value="MITOCHONDRIA-EATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21771">
        <property type="entry name" value="MITOCHONDRIA-EATING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16026">
        <property type="entry name" value="MIEAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mitochondria-eating protein C-terminal" evidence="14">
        <location>
            <begin position="180"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="142"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="158"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005012591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="395" mass="45113" checksum="28A66676C77F270C" modified="2022-01-19" version="1">MAGSLRKLVKAESCQLMQEKLESWAKDYEINSCDQNLNQCCELLEMTSVIQRQLFAILNETSQEGGHYAGVDTIKTRLLPWLGTSFSYATSGRLFETSLSLTQDSIEKERQLRQLATSQTFHLQELQEELTSTRLELDHVQQEIARSRSPSPRRVRSRSPSPLPLRSFSPGRARRTNASRHTFLVARFGDIYSKDRFDAERILRAYIDDMEMVQRIIYTAVVESFQAAKMAYRQFKIRVRKTLSIGHTGPESLEDTVMDYIVRHEDLYDVQASVNEVIRSMNISPKISSPPELDFAVISSFIRDLCRVAFSMQTLIPPLDVAFGMDGEFFSETKYHRSVDSDYTAALVAYHVWPALMENDVVIVKGEAVTKRGALLPRSRSPSPQRCGSPSRWEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TIC9</accession>
    <name>A0A8C2TIC9_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">PBX homeobox 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">PBX3</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TALE/PBX homeobox family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015734903.1">
        <property type="nucleotide sequence ID" value="XM_015879417.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TIC9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005018870.1">
        <property type="protein sequence ID" value="ENSCJPP00005013094.1"/>
        <property type="gene ID" value="ENSCJPG00005011074.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107321934"/>
    <dbReference type="KEGG" id="cjo:107321934"/>
    <dbReference type="CTD" id="5090"/>
    <dbReference type="GeneTree" id="ENSGT00940000154374"/>
    <dbReference type="OrthoDB" id="4187154at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008344">
        <property type="term" value="P:adult locomotory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021516">
        <property type="term" value="P:dorsal spinal cord development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048666">
        <property type="term" value="P:neuron development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002087">
        <property type="term" value="P:regulation of respiratory gaseous exchange by nervous system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007585">
        <property type="term" value="P:respiratory gaseous exchange by respiratory system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000008">
        <property type="entry name" value="Pre-B-cell leukemia transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005542">
        <property type="entry name" value="PBX_PBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050224">
        <property type="entry name" value="TALE_homeobox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11850">
        <property type="entry name" value="HOMEOBOX PROTEIN TRANSCRIPTION FACTORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03792">
        <property type="entry name" value="PBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51978">
        <property type="entry name" value="PBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="PBC" evidence="11">
        <location>
            <begin position="40"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="232"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="8">
        <location>
            <begin position="234"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="402"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="325"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005013094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="433" mass="47103" checksum="08FECEAEFA5637B1" modified="2022-01-19" version="1">MDEQSRMLQTLAGVNLAGHSVQGGMALPPPHGHDGADGDGRKQDIGDILHQIMTITDQSLDEAQAKKHALNCHRMKPALFSVLCEIKEKTGLSIRGAQEEDPPDPQLMRLDNMLLAEGVSGPEKGGGSAAAAAAAAASGGSSDNSIEHSDYRAKLTQIRQIYHTELEKYEQACNEFTTHVMNLLREQSRTRPISPKEIERMVGIIHRKFSSIQMQLKQSTCEAVMILRSRFLDARRKRRNFSKQATEILNEYFYSHLSNPYPSEEAKEELAKKCSITVSQVSNWFGNKRIRYKKNIGKFQEEANLYAAKTAVTAAHAVAAAVQNNQTNSPTTPNSGSSGSFNLPNSGDMFMNMQSLNGDSYQGAQVGANVQSQVDTLRHVINQTGGYNDGLGGNSLYSPHNLNANGGWQDATTPSSVTSPTEGPGSVHSDTSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TIS1</accession>
    <name>A0A8C2TIS1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Protein phosphatase 1G</fullName>
            <ecNumber evidence="5">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">PPM1G</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:47005"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="18">Interacts with NOL3; may dephosphorylate NOL3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 21">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="5"/>
    <dbReference type="RefSeq" id="XP_015715042.1">
        <property type="nucleotide sequence ID" value="XM_015859556.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TIS1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005020334.1">
        <property type="protein sequence ID" value="ENSCJPP00005014248.1"/>
        <property type="gene ID" value="ENSCJPG00005011911.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107312276"/>
    <dbReference type="KEGG" id="cjo:107312276"/>
    <dbReference type="CTD" id="5496"/>
    <dbReference type="GeneTree" id="ENSGT00940000158427"/>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000023">
        <property type="entry name" value="Protein phosphatase, Mg2+/Mn2+-dependent, 1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000029">
        <property type="entry name" value="Protein phosphatase, Mg2+/Mn2+-dependent, 1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF803">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0007">Acetylation</keyword>
    <keyword evidence="11 21" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16" id="KW-0464">Manganese</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0488">Methylation</keyword>
    <keyword evidence="8" id="KW-0519">Myristate</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13 21" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="23">
        <location>
            <begin position="26"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="171"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="525"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="22">
        <location>
            <begin position="123"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="203"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="220"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="22">
        <location>
            <begin position="277"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="552"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00038798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00040767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005014248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="561" mass="60759" checksum="1482312CA0DA648B" modified="2022-01-19" version="1">MGAYLSQPNTVKSSGDGAGLGPRPLHFGFSAMQGWRVSMEDAHNCIPELDSETAMFSVYDGHGGEEVALYCAKYLPEIIKDQKAYKEGKLQKALEDAFLAIDAKLTTEEVIKELSQMAGRPQDDEDEKEKVADEDDVDNEEAALLHEEATMTIEELLTRYGQNCTKNLKHKSLAPAGDNAAEGTGKQHDGESNMNGEADPGDLIDHKERKNGKPDEEFTGISSTSDKASTGGNSPALQKPELGKGDEAVTSSTGEAGPSCSSTGKPQRTTKSKFFEDSEDESDEVEEEEEDSEECSEDEDGYSSEEAENEDDEDDTEEAEEDEDEEEEMLLPGMEGKEEPGSDSGTTAVVALIRGKQLIVANAGDSRCVVSEGGKAVDMSYDHKPEDEVELARIKNAGGKVTMDGRVNGGLNLSRAIGDHFYKRNKNLPPEEQMISALPDIKVLTINDDHDFMVIACDGIWNVMSSQEVVDFIQSKITQKDENGVLRPLSSIVEELLDQCLAPDTSGDGTGCDNMTCIIISFKPRNTHPPAESGKRKLDDVAAPAAPAEENGSDKKKAKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TJ10</accession>
    <name>A0A8C2TJ10_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="27">Glycine receptor alpha 4 (pseudo</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="27" type="primary">LOC107312646</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="27" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="27" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>chloride(in) = chloride(out)</text>
            <dbReference type="Rhea" id="RHEA:29823"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Postsynaptic cell membrane</location>
            <topology evidence="20">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="24">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TJ10"/>
    <dbReference type="Ensembl" id="ENSCJPT00005017937.1">
        <property type="protein sequence ID" value="ENSCJPP00005012376.1"/>
        <property type="gene ID" value="ENSCJPG00005010521.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158789"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098690">
        <property type="term" value="C:glycinergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099634">
        <property type="term" value="C:postsynaptic specialization membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016934">
        <property type="term" value="F:extracellularly glycine-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016594">
        <property type="term" value="F:glycine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022824">
        <property type="term" value="F:transmitter-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043200">
        <property type="term" value="P:response to amino acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd19060">
        <property type="entry name" value="LGIC_TM_GlyR_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000002">
        <property type="entry name" value="Glycine receptor alpha 1 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000003">
        <property type="entry name" value="Glycine receptor alpha 2 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008127">
        <property type="entry name" value="Glycine_rcpt_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01673">
        <property type="entry name" value="GLYRALPHA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-0966">Cell projection</keyword>
    <keyword evidence="14" id="KW-0868">Chloride</keyword>
    <keyword evidence="12" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="10 22" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="18 24" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 24" id="KW-0406">Ion transport</keyword>
    <keyword evidence="17" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="9 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 24" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 24" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="297"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="25">
        <location>
            <begin position="37"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="26">
        <location>
            <begin position="239"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <begin position="214"/>
            <end position="219"/>
        </location>
        <ligand>
            <name>strychnine</name>
            <dbReference type="ChEBI" id="CHEBI:90700"/>
            <note>antagonist</note>
        </ligand>
    </feature>
    <feature type="site" description="Important for obstruction of the ion pore in the closed conformation" evidence="21">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="22">
        <location>
            <begin position="160"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="22">
        <location>
            <begin position="210"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00024167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR608127-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR608127-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR608127-53"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005012376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="433" mass="49956" checksum="77DA3252005AA989" modified="2022-01-19" version="1">FAPALVLGEAWLVSGREEIKSHSRSAPQPMSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSVTETTMDYRVNIFLRQQWNDPRLAYNEYPDDSLDLDPSMLDSIWKPDLFFANEKGAHFHEITTDNKLLRIFKNGNVLYSIRLTLILACPMDLKNFPMDIQTCTMQSFGWLEEQEAVQVAEGLTLPQFILRDEKDLGYCTKYYNTGKFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKEFMRLRRRQRRQRMEEELIRESRFYFRGYGLGHCLQAKEGAGEGPGIYSPPPPSALLREGETLHKRYIDRAKRIDTISRAVFPFTFLVFNIFYWVVYKVLRSEDIHPVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TJF5</accession>
    <name>A0A8C2TJF5_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Metalloendopeptidase OMA1, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Overlapping with the m-AAA protease 1 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">OMA1</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homooligomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase M48 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TJF5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005021042.1">
        <property type="protein sequence ID" value="ENSCJPP00005014819.1"/>
        <property type="gene ID" value="ENSCJPG00005012337.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107317776"/>
    <dbReference type="KEGG" id="cjo:107317776"/>
    <dbReference type="CTD" id="115209"/>
    <dbReference type="GeneTree" id="ENSGT00390000007027"/>
    <dbReference type="OrthoDB" id="7464992at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002024">
        <property type="term" value="P:diet induced thermogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140468">
        <property type="term" value="P:HRI-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033108">
        <property type="term" value="P:mitochondrial respiratory chain complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010637">
        <property type="term" value="P:negative regulation of mitochondrial fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120162">
        <property type="term" value="P:positive regulation of cold-induced thermogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901526">
        <property type="term" value="P:positive regulation of mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016540">
        <property type="term" value="P:protein autoprocessing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070585">
        <property type="term" value="P:protein localization to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903850">
        <property type="term" value="P:regulation of cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006413">
        <property type="term" value="P:translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031638">
        <property type="term" value="P:zymogen activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd07331">
        <property type="entry name" value="M48C_Oma1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051156">
        <property type="entry name" value="Mito/Outer_Membr_Metalloprot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726">
        <property type="entry name" value="METALLOENDOPEPTIDASE OMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726:SF1">
        <property type="entry name" value="METALLOENDOPEPTIDASE OMA1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M48" evidence="13">
        <location>
            <begin position="222"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="450"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="450"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="462"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005014819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="471" mass="54176" checksum="E12C3DA2BFA99DF8" modified="2022-01-19" version="1">MNITCGFKLLRRNCLFFRLPLAQTKNCYRTCLVKGQSCVSNVPSTEVWKNAHHVSRRLCFQSPRLLKEKITSLQISSVGPIPNGLSAGNTQLIRSFHTSPSLRAAPFPLFWILFKPVQKLFAILIGRSIRKWWKALPPNKRELFKESVRTNKWKILLGVCSLGVLFVVFYFTHLEETPITGRARLLVFRKEHLRQLSQMEYSMWMAKYESKMLPETDARYQVVKRVVGHLSESNKDIPQFSTLIWSIHVVDEPEVNAFVLPNGEVFVFTGLLNAVSDIHQLSFILGHEIAHAVLEHAIEKASLVHFLDFLSLIFLTMIWAICPHDILAVVGQRIQSKLQEFIFDRPYSRTLEAEADKVGLQFAAKACVDVRASSVFWQLMELVETVKGEPRLPEWLSTHPSHENRAEHLDRLIPEALKIRERCNCPSLSGPDPRLVFRLNRQHLLESFKAQETQNSTNQDLSKMKLDFPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TN11</accession>
    <name>A0A8C2TN11_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TN11"/>
    <dbReference type="Ensembl" id="ENSCJPT00005020214.1">
        <property type="protein sequence ID" value="ENSCJPP00005014146.1"/>
        <property type="gene ID" value="ENSCJPG00005011841.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161976"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041681">
        <property type="entry name" value="PH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001605">
        <property type="entry name" value="PH_dom-spectrin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34147:SF3">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 4 WD40 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34147">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15410">
        <property type="entry name" value="PH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00683">
        <property type="entry name" value="SPECTRINPH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="1">
        <location>
            <begin position="37"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005014146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="341" mass="36732" checksum="2316FB31E5874CD4" modified="2022-01-19" version="1">MEREGCHQPHGCPTAAPHIQPHLPIEPISVVPNRHLERQRCPLFVGVNGGKKAPWGRRGWKSFHAVLRGTLLCFLKVGAAPTAEAEEMLGVHHGLAEQDSHYTKRPHVFRLHTADSRVLLLQAPSHADMLAWISRLNLAAALLSSPPFPAAVGSQRRLTRHILPAAPSHCPPVSGDGGYGGLWGAMGRYGGLWGAMGRYGALWGTMGLYGALWGSMGRYGGLWGSMGCYGALWGSMGRYGALWGHMGLYGALWGAMGALWGHYGVSMGPYGVPMGSLWGHKRSSWGLWGHYGDIIGTLWGHYGDTMGSLWGHYGVSMGSLWGLYGVSMGLKGHYGDTMGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TNS7</accession>
    <name>A0A8C2TNS7_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TNS7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005021531.1">
        <property type="protein sequence ID" value="ENSCJPP00005015156.1"/>
        <property type="gene ID" value="ENSCJPG00005012595.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="84" mass="9242" checksum="09C9DE447B02F62A" modified="2022-01-19" version="1">SVVASLFRASHPARQTQMMKSCVSNLCDNQGMTNVVENQKSRPWKIRHEIVCSVILRVSAPCGVSSHQGNGTTEDLPRFSGEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TPV0</accession>
    <name>A0A8C2TPV0_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tissue factor pathway inhibitor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TFPI</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TPV0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005023593.1">
        <property type="protein sequence ID" value="ENSCJPP00005016866.1"/>
        <property type="gene ID" value="ENSCJPG00005013821.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160767"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005901">
        <property type="term" value="C:caveola"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071383">
        <property type="term" value="P:cellular response to steroid hormone stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030195">
        <property type="term" value="P:negative regulation of blood coagulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd22613">
        <property type="entry name" value="Kunitz_TFPI1_1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22614">
        <property type="entry name" value="Kunitz_TFPI1_2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22615">
        <property type="entry name" value="Kunitz_TFPI1_TFPI2_3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.10:FF:000004">
        <property type="entry name" value="Tissue factor pathway inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.10:FF:000013">
        <property type="entry name" value="Tissue factor pathway inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020901">
        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050098">
        <property type="entry name" value="TFPI/VKTCI-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10083">
        <property type="entry name" value="KUNITZ-TYPE PROTEASE INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10083:SF328">
        <property type="entry name" value="TISSUE FACTOR PATHWAY INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00759">
        <property type="entry name" value="BASICPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00280">
        <property type="entry name" value="BPTI_KUNITZ_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034294332" evidence="5">
        <location>
            <begin position="24"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="6">
        <location>
            <begin position="48"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="6">
        <location>
            <begin position="117"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="6">
        <location>
            <begin position="206"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005016866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="326" mass="37196" checksum="814591DE691CF1D1" modified="2022-01-19" version="1">MKGRKRGWFLAFSFILLYSTANQLDNSCPVFFITGVPLPPLKLGHSDCALKADEGPCKAIHMRFYFNIRSRECEIFEYGGCQGNANNFLTLEECQNKCVVTGQYPFSSSSIKKPNLCYHDKDPGICRGFFSRYFYNKETKKCELFMYGGCLGNRNNFRSLEECQATCQGNLVPNEERPTHMNSSSPEEEPNQLPGIFEPPPIPSLCLTPMDKGLCRAKETRFFYNYSTGRCRPFTYSGCGGNENNFTSRKSCLRICRKGMGTDIATECHKRQVLCMLWAEIFLWKKINKNQEKKETVTKDQGGGNHPRKNTALIFMEMGSKLLLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TQE8</accession>
    <name>A0A8C2TQE8_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Keratin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the avian keratin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TQE8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005024039.1">
        <property type="protein sequence ID" value="ENSCJPP00005017215.1"/>
        <property type="gene ID" value="ENSCJPG00005014080.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234722"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005882">
        <property type="term" value="C:intermediate filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003461">
        <property type="entry name" value="Keratin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31203">
        <property type="entry name" value="BETA-KERATIN-RELATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31203:SF1">
        <property type="entry name" value="BETA-KERATIN-RELATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02422">
        <property type="entry name" value="Keratin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0416">Keratin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005017215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="116" mass="11812" checksum="51D8B9A76F85B593" modified="2022-01-19" version="1">MSCYDLCAPTTCGPTPLANSCSEPCVRQCQDSTVVIQPSPVVVTLPGPILSSFPQNTTVGSSASAAVGSALSAGGVPISSGSSLGFGSFAYPSLGSGYSRPYRRYNTYRSSFNGPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TQV7</accession>
    <name>A0A8C2TQV7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">CD6</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Binds to extracellular matrix proteins. Binds to pathogen-associated molecular patterns (PAMPs) present on the cell walls of Gram-positive and Gram-negative bacteria and fungi, behaving as a pattern recognition receptor (PRR). Induces bacterial and fungal aggregation and subsequent inhibition of PAMP-induced cytokine release. Does not possess intrinsic bactericidal activity. May play a role in the innate defense and homeostasis of certain epithelial surfaces.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with LGALS1 and laminin.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TQV7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005022534.1">
        <property type="protein sequence ID" value="ENSCJPP00005015977.1"/>
        <property type="gene ID" value="ENSCJPG00005013176.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161029"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001772">
        <property type="term" value="C:immunological synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042101">
        <property type="term" value="C:T cell receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001530">
        <property type="term" value="F:lipopolysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070891">
        <property type="term" value="F:lipoteichoic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002438">
        <property type="term" value="P:acute inflammatory response to antigenic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007157">
        <property type="term" value="P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001771">
        <property type="term" value="P:immunological synapse formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031663">
        <property type="term" value="P:lipopolysaccharide-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900017">
        <property type="term" value="P:positive regulation of cytokine production involved in inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042102">
        <property type="term" value="P:positive regulation of T cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031638">
        <property type="term" value="P:zymogen activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000017">
        <property type="entry name" value="CD6 molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000007">
        <property type="entry name" value="Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071:SF29">
        <property type="entry name" value="OLFACTORY RECEPTOR 292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00420">
        <property type="entry name" value="SRCR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="251"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="12">
        <location>
            <begin position="13"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="12">
        <location>
            <begin position="143"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="296"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="387"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="172"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00058074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00064153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00069168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="448" mass="48381" checksum="6882F8C871F14C12" modified="2022-01-19" version="1">LTGPLFCTESPALRLVGGRSRCEGRVELRKEGKWGTVCDDGWDLADADVVCRQLGCGWALRAPREAAFGWGHGPVLQDEVNLVPWLCPVLMPWCHPDPRRALAEHHEWRLSGGRDGCAGRVEVLYRGTWSTVCDSTWYEMEAEVLCRTLGCGEQLQRPSFRHTLPTKMLYECPDWQPSLAYCRWTYNKSAPCHESRAAGVICSGTAPFGPTGRALGQRPLWVPGLQPPSPLSSSTKGLEAGAALSPLHVPLSILCAVLAALLLLTLVAFTTALLHLRKRSGEALLVTSAPALSLPADPTPTILPTTKGSDSSDSDYEHYDFSSKPPVALSTFHSEIPPAPLHLPSLLGSPVDPVPPTPQTHSADSWVSSCWCPARMGWSHFPQRLSTPWVPPQPPDPDCAGSSSTSSGEWYENVQGAETCGDPAPGEHTQDSSFSEGSDYDDIQGSGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TS10</accession>
    <name>A0A8C2TS10_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Glutamine-dependent NAD(+) synthetase</fullName>
            <ecNumber evidence="4 10">6.3.5.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">NAD(+) synthase [glutamine-hydrolyzing]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">NADSYN1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>deamido-NAD(+) + L-glutamine + ATP + H2O = L-glutamate + AMP + diphosphate + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24384"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homohexamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">In the C-terminal section; belongs to the NAD synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.1" evidence="4 10"/>
    <dbReference type="RefSeq" id="XP_015718843.1">
        <property type="nucleotide sequence ID" value="XM_015863357.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TS10"/>
    <dbReference type="Ensembl" id="ENSCJPT00005023722.1">
        <property type="protein sequence ID" value="ENSCJPP00005016943.1"/>
        <property type="gene ID" value="ENSCJPG00005013780.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107314275"/>
    <dbReference type="KEGG" id="cjo:107314275"/>
    <dbReference type="CTD" id="55191"/>
    <dbReference type="GeneTree" id="ENSGT00390000010152"/>
    <dbReference type="OrthoDB" id="2020662at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00334"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd07570">
        <property type="entry name" value="GAT_Gln-NAD-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00553">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000036">
        <property type="entry name" value="Glutamine-dependent NAD(+) synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.110.10:FF:000007">
        <property type="entry name" value="Glutamine-dependent NAD(+) synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02090">
        <property type="entry name" value="NadE_glutamine_dep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014445">
        <property type="entry name" value="Gln-dep_NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00552">
        <property type="entry name" value="nadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090:SF9">
        <property type="entry name" value="GLUTAMINE-DEPENDENT NAD(+) SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="NH 3 /GLUTAMINE-DEPENDENT NAD + SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006630">
        <property type="entry name" value="NADS_GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="9 10" id="KW-0520">NAD</keyword>
    <keyword evidence="7 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="11">
        <location>
            <begin position="5"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR006630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005016943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="707" mass="78897" checksum="B644731B6717BB82" modified="2022-01-19" version="1">MGRAVTVAACALNQWALDFEGNAERILRSISIAKSKGARYRLGPELEICGYGCADHYYESDTLLHSFQVLAKLLKSPVAQDMICDVGMPVMHRNVRYNCRVIFLNKKILLIRPKISLANAGNYRELRWFTPWNKARHVEEYLLPRIIQEVTGQDTVPFGDAVLATEDTCLGTEICEELWAPNSPHIEMGLDGVEIFTNSSGSHHVLRKAHTRVDLVNSATAKNGGIYILSNQKGCDGDRLYYDGCAMISMNGETIAQGSQFSLDDVEVLVATLDLEDVRSYRAEISSRNLAASKVNPFPRIKVNFALSCSDDLAVPISVPIQWRHHSPGEEICLGPACWLWDYLRRSKQAGFLLPLSGGIDSSATACIVYSMCHQVCLAVKNGNAEVLADARRIVHDETYIPEDPREFCKRVFTTCYMASENSSQDTCNRAKLLAEQIGSYHINLNIDAAVKAIVGIFSMVTGRTPCFAVYGGSSRENLALQNVQARVRMVLAYLFAQLTLWTRGMPGGLLVLGSANVDESLRGYLTKYDCSSADINPIGGISKTDLKSFIQYCIENFQLSALKSIVAAPPTAELEPLVDGQASQTDEADMGMTYAELSIYGKLRKIAKAGPYSMFLKLINLWKETCTPREVASKVKHFFRTYSQNRHKMTTLTPSYHAENYSPDDNRFDLRPFLYNTTWSWQFRCIDNQVSRLERKEGISVSEDTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TSC3</accession>
    <name>A0A8C2TSC3_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phorbol-ester/DAG-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TSC3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005023864.1">
        <property type="protein sequence ID" value="ENSCJPP00005017075.1"/>
        <property type="gene ID" value="ENSCJPG00005013976.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158341"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032587">
        <property type="term" value="C:ruffle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045666">
        <property type="term" value="P:positive regulation of neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035023">
        <property type="term" value="P:regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051632">
        <property type="entry name" value="Rho_GEF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13944">
        <property type="entry name" value="AGAP007712-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13944:SF20">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="3">
        <location>
            <begin position="40"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005017075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="114" mass="12517" checksum="749EAA095F60D21F" modified="2022-01-19" version="1">MGWLHLWGRQDEVPSSVRAVGQSKDRMKEGKDKDARYTNGHLLSSITVSGMTMCFACNKSITAKEALSCPTCNVTIHNRCKDTLPNCTKVKQKVSVGLGGVSWAWMGIWAWDGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TSG8</accession>
    <name>A0A8C2TSG8_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Carbohydrate sulfotransferase</fullName>
            <ecNumber evidence="11">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">CHST8</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Golgi apparatus membrane</location>
            <topology evidence="1 11">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the sulfotransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="11"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2TSG8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005025013.1">
        <property type="protein sequence ID" value="ENSCJPP00005018006.1"/>
        <property type="gene ID" value="ENSCJPG00005014622.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159100"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001537">
        <property type="term" value="F:dermatan 4-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016051">
        <property type="term" value="P:carbohydrate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042446">
        <property type="term" value="P:hormone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030166">
        <property type="term" value="P:proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018011">
        <property type="entry name" value="Carb_sulfotrans_8-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005331">
        <property type="entry name" value="Sulfotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137:SF7">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03567">
        <property type="entry name" value="Sulfotransfer_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034313505" description="Carbohydrate sulfotransferase" evidence="13">
        <location>
            <begin position="18"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="41"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005018006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="414" mass="48723" checksum="11D9A8F6542DAE80" modified="2022-01-19" version="1">MRLTCMFSFILLFGAAGLVVFIHLQDPEEIVHQQTPGYKHLGSPFSMGSPHQSLSPGLHGSLHPPENVPSKFQSTDRRQSSTTFMKDYQEKGEETNSMRLHKRRRRFVIKKSPILISMNSSTPNLPTLKSDDGNNKWKSLYQIQSKRKQIMKETCSKYKSNNRRIITPYHVSRIFVEDKYRVLYCEVPKAGCSNWKRVLMVLNGLASSTKDIQHNTVHYGNYLKRLDGFDRKGIYHRLNTYTKMLFIREPFEKLVSAFRDKFEHPNNYYHPVFGKAIISRYRVNATKEALRTGSGVKFKEFIQYLLDVHRPVGMDIHWDHVNRLCSPCLIDYDFVGKFESMEEDANFFLHLIGAPQNLTFPKFKDRHSNEERTTTKITQQYFAQLSPSQRQRSYDFYYMDYLMFNYSKPFEDLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TT05</accession>
    <name>A0A8C2TT05_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Palmitoyltransferase</fullName>
            <ecNumber evidence="12">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ZDHHC13</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="12"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2TT05"/>
    <dbReference type="Ensembl" id="ENSCJPT00005023737.1">
        <property type="protein sequence ID" value="ENSCJPP00005016958.1"/>
        <property type="gene ID" value="ENSCJPG00005013888.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063074"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030660">
        <property type="term" value="C:Golgi-associated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161:SF16">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="372"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="465"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="514"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="82"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="116"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="217"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="13">
        <location>
            <begin position="419"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005016958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="615" mass="70462" checksum="450E6E9B6E3BC1DD" modified="2022-01-19" version="1">MFDDGPFVNQQCKKHCHGPHRPHVHGCHSVCREKDVPVLPGLHPDAEDPSTCDIVKATQYGMVERCKELVEAGYDVRQPDKENVTLLHWAAINNRQELVKYYISKGAVVDQLGGDLNSTPLHWAIRQGHLPMVILLLKCGADPSLIDGEGFSSIHLAVLFQHVPIVAYLISKGQVCYTADFNGFTPLMLSAQRVMGPEPTRFLLKFNPSLNAVDNIERNTALHWAITSGNVSAVELLLEGGANMDIKNAKGETALDLAIQTQNRFMVYMLMEEERIRSRRNNRLLRIMEKYELFMLLASCLTLMWAIGYVMSLNSESWLLKGCLLFFLLVGMVLFVRHFVGFKNLRYLPTALMLSSIFWMSMTWFFWFMPDILYTGGIIVGLLYFFYKTWRTDPGYIKSSEKDKKENIVALAEAGCLDFRTFCTSCLVRKPLRSVHCLLCDLCVARYDQHSLWIAQCIGVGNHHYYLLFLSFLTVTSVWLLYRTVLYWSHHCETSYHADGAWTYLVQITSCSPWVSYVFVLACFHAVWALLWLTIQLYQIAFLGLTSHERMNLLMDSKSSKHPVSLRRNPYNLGCFQNLADFFQCRCFGMVKPNGVDWTKQYNVNVIKKMNIHSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TU07</accession>
    <name>A0A8C2TU07_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Zinc finger FYVE domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">ZFYVE1</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="13">Interacts with RAB18 (in GTP-bound form). Interacts with BSCL2 in a RAB18-dependent manner. Interacts with ZW10.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
            <location evidence="3">Golgi stack</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Lipid droplet</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015720084.1">
        <property type="nucleotide sequence ID" value="XM_015864598.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015720085.1">
        <property type="nucleotide sequence ID" value="XM_015864599.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015720086.1">
        <property type="nucleotide sequence ID" value="XM_015864600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TU07"/>
    <dbReference type="SMR" id="A0A8C2TU07"/>
    <dbReference type="Ensembl" id="ENSCJPT00005025605.1">
        <property type="protein sequence ID" value="ENSCJPP00005018376.1"/>
        <property type="gene ID" value="ENSCJPG00005014968.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107314859"/>
    <dbReference type="KEGG" id="cjo:107314859"/>
    <dbReference type="CTD" id="53349"/>
    <dbReference type="GeneTree" id="ENSGT00390000016097"/>
    <dbReference type="OrthoDB" id="68108at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097629">
        <property type="term" value="C:extrinsic component of omegasome membrane"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044233">
        <property type="term" value="C:mitochondria-associated endoplasmic reticulum membrane contact site"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005545">
        <property type="term" value="F:1-phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005547">
        <property type="term" value="F:phosphatidylinositol-3,4,5-trisphosphate binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043325">
        <property type="term" value="F:phosphatidylinositol-3,4-bisphosphate binding"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:cellular response to starvation"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:host-mediated activation of viral genome replication"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:lipid droplet formation"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="CDD" id="cd19819">
        <property type="entry name" value="Bbox1_ZFYVE1_rpt1"/>
        <property type="match status" value="1"/>
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    <dbReference type="CDD" id="cd19820">
        <property type="entry name" value="Bbox1_ZFYVE1_rpt2"/>
        <property type="match status" value="1"/>
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    <dbReference type="CDD" id="cd15734">
        <property type="entry name" value="FYVE_ZFYV1"/>
        <property type="match status" value="1"/>
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    <dbReference type="CDD" id="cd01851">
        <property type="entry name" value="GBP"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Zinc finger FYVE domain-containing protein 1"/>
        <property type="match status" value="2"/>
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    <dbReference type="FunFam" id="3.40.50.300:FF:000719">
        <property type="entry name" value="Zinc finger FYVE domain-containing protein 1"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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    <dbReference type="InterPro" id="IPR042427">
        <property type="entry name" value="ZFYV1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047856">
        <property type="entry name" value="ZFYVE1_first_BBox1"/>
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    <dbReference type="InterPro" id="IPR047855">
        <property type="entry name" value="ZFYVE1_second_BBox1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
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    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
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    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
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    <dbReference type="PANTHER" id="PTHR46624">
        <property type="entry name" value="AGAP002036-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46624:SF3">
        <property type="entry name" value="ZINC FINGER FYVE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22586">
        <property type="entry name" value="ANCHR-like_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0551">Lipid droplet</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B box-type" evidence="16">
        <location>
            <begin position="13"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="17">
        <location>
            <begin position="602"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="17">
        <location>
            <begin position="719"/>
            <end position="779"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
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            <dbReference type="ARBA" id="ARBA00022677"/>
        </source>
    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022824"/>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00072911"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
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        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005018376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="781" mass="87708" checksum="591DC51DF85E5735" modified="2022-01-19" version="1">MSAHTQTAEKGQNTALLCQESYVCSGTDEAVFECDECRSLQCQRCEEELHQPERLRNHERTRIRPGHVPYCDSCKGANGNIMHASMTGSRQIAAVRCQVCKINLCVECQKRTHAGGNRRKHPVTVYHAGKAQEQEEEEMDEETRRRKMAEKVVSFLLVDETEEIQVRNEEDFIKKLDCSPDQHLKVVSIFGNTGDGKSHTLNHAFFYGREVFKTSPAQESCTVGVWAAYDPVRKVVVIDTEGLLGATVNLSQRTRLLLKVLAISDLVIYRTRADRLHNDLFKFLGDASEAYLKHFTKELKATTARCGLDVPLSTLGPGVIIFHETVYTKLLGSDHPSEVPEKLIQDRFRKLSCFPEAFSSIHYKGTRTYNPPTDFSGLRRAVEQQLENNTTRSPRQPGVIYKALKALSDRFSGEIPDDQMAHSSFFPDEYFTCSSVCLSCGCGCKKSMNHTKEGVPHESKSRCRYSHQYDNRVYTCKACYERGMEVSVVPKTSASTDSPWLGLAKYAWSGYVIECPNCGVVYRSRQYWFGNQDPVNTVVRTEIEHVWPGTDGFLKDNNNAAQRLLDGMNFMAQSVSELSLGPTKAVTSWLTDQIAPAYWRPNSQILSCNKCNTPFKDNDTKHHCRACGEGFCDGCSSKTRPVPERGWGPAPVRVCDNCYENRGIQLDVAELPSDEEGGTLIARKVGEAVQNTLGAVVTAMDIPLGLVKDAARPAYWVPDHEILHCHNCRKEFSIKLSKHHCRACGQGFCDECSHDRRAVPSRGWDHPVRVCFNCNKKPGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TUC9</accession>
    <name>A0A8C2TUC9_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Histidine-rich glycoprotein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Histidine-proline-rich glycoprotein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">HRG</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015727175.1">
        <property type="nucleotide sequence ID" value="XM_015871689.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TUC9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005023536.1">
        <property type="protein sequence ID" value="ENSCJPP00005016812.1"/>
        <property type="gene ID" value="ENSCJPG00005013786.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107318177"/>
    <dbReference type="KEGG" id="cjo:107318177"/>
    <dbReference type="CTD" id="3273"/>
    <dbReference type="GeneTree" id="ENSGT00950000182930"/>
    <dbReference type="OrthoDB" id="9941887at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072562">
        <property type="term" value="C:blood microparticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004869">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007596">
        <property type="term" value="P:blood coagulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042730">
        <property type="term" value="P:fibrinolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051918">
        <property type="term" value="P:negative regulation of fibrinolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060255">
        <property type="term" value="P:regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010543">
        <property type="term" value="P:regulation of platelet activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00042">
        <property type="entry name" value="CY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.10:FF:000005">
        <property type="entry name" value="Histidine-rich glycoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000010">
        <property type="entry name" value="Cystatin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046350">
        <property type="entry name" value="Cystatin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050735">
        <property type="entry name" value="Kininogen_Fetuin_HRG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13814">
        <property type="entry name" value="FETUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13814:SF3">
        <property type="entry name" value="HISTIDINE-RICH GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00031">
        <property type="entry name" value="Cystatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00043">
        <property type="entry name" value="CY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54403">
        <property type="entry name" value="Cystatin/monellin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0094">Blood coagulation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0280">Fibrinolysis</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0356">Hemostasis</keyword>
    <keyword evidence="3" id="KW-0358">Heparin-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034966381" description="Histidine-rich glycoprotein" evidence="16">
        <location>
            <begin position="19"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="domain" description="Cystatin" evidence="17">
        <location>
            <begin position="18"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Cystatin" evidence="17">
        <location>
            <begin position="140"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="271"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="650"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="274"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="322"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="385"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="448"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="492"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="519"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="578"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="669"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="698"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00041330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005016812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="714" mass="80955" checksum="CC345B4D28F9DC52" modified="2022-01-19" version="1">MLCLTSAFFLALLHCCNAQIKTSQVTVPTDCESIETEAGMVLDLVNRHRQDGYVFGLLRVADAHKLQTENSSVLYLTLDVLETECSVLSGRPWETCEYGDLYSMDFGQCKIITYTSQMLKKPKLYGYNCTLSPVPPDLIECKDCPVKVEVLEVIEQHKDIAAKLLEKFNHEGNHTNYFKVDKVEKILKATASREVHILGFSIKETNCSRGEQQQTDEPLECEFLDDWHAHTGFCKARIVTDPDEPNGMEINCELYHPWQRYYGQRCRSPAPGWPHKHHHHHRHRHRHRGPPTFQFKPGDSEHNHDFNRDQQDSHEEPPPPCHGRHHHHHPPHHGQPPAPQEEPEHPSSTPPLYDKQHRPPLIQEKSDFPPSAPPQYDEQHNPPPPHHHGPHCPPPHGHHHPHHPHHHGPHCPPPHGHHHPHHPHHHGPHCPPPHGHHHPHHPHHHGPHCPPPHGCHHPPPPPQEEPEHTSSAPLYDKQHSPPLIQEKSGFPPSTPPPYDEQHSPPPCPHHGPRCPPPHGHYHPPPHHHGPHCPPPHGHHHLPPPPHHGPHCHPNGHHHPPPPPHHGPHCHPHGHHHPPPPPHHGPHCPPPPPPPGHHPYLYHHYHRHHCNKTHTSGKYFPFQVTGAVYRIPVQNMQDSLTPPRAEFPELSLLGPHSVGTDEGTPFTDSSLREMPEAPHFPDHPSQSKSCPGKPKLDLPKILPLLPHKSTAVTPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TUJ8</accession>
    <name>A0A8C2TUJ8_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleolar protein 58</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Nucleolar protein 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">NOP58</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the biogenesis of box C/D snoRNAs such as U3, U8 and U14 snoRNAs. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) complexes that function in methylation of multiple sites on ribosomal RNAs (rRNAs) and messenger RNAs (mRNAs).</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles; the core proteins SNU13, NOP56, NOP58 and FBL or FBLL1 assemble stepwise onto the snoRNA. Interacts with NOLC1/Nopp140. Interacts with NOPCHAP1, NUFIP1, RUVBL1 and RUVBL2; NOPCHAP1 bridges the association of NOP58 with RUVBL1:RUVBL2 and NUFIP1. Interacts with PIH1D1. Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP5/NOP56 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015723679.1">
        <property type="nucleotide sequence ID" value="XM_015868193.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TUJ8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005026183.1">
        <property type="protein sequence ID" value="ENSCJPP00005018895.1"/>
        <property type="gene ID" value="ENSCJPG00005015334.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107316546"/>
    <dbReference type="KEGG" id="cjo:107316546"/>
    <dbReference type="CTD" id="51602"/>
    <dbReference type="GeneTree" id="ENSGT00940000153534"/>
    <dbReference type="OrthoDB" id="6780543at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015030">
        <property type="term" value="C:Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001650">
        <property type="term" value="C:fibrillar center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070761">
        <property type="term" value="C:pre-snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001094">
        <property type="term" value="F:TFIID-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048254">
        <property type="term" value="P:snoRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.90:FF:000004">
        <property type="entry name" value="Nucleolar protein 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.4070:FF:000001">
        <property type="entry name" value="Probable Nucleolar protein 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045056">
        <property type="entry name" value="Nop56/Nop58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012974">
        <property type="entry name" value="NOP58/56_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894">
        <property type="entry name" value="NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894:SF1">
        <property type="entry name" value="NUCLEOLAR PROTEIN 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08156">
        <property type="entry name" value="NOP5NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Nop" evidence="10">
        <location>
            <begin position="283"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="463"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="480"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00060303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00063404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00082313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005018895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="527" mass="59209" checksum="CC3F9FE3222BD5E2" modified="2022-01-19" version="1">MLVLFETAAGYAIFKVLNEKKLQEVDSLWKEFETPEKANKIVKLKHFEKFQDTTEALAASTALVEGKLSKNLKKILKKIVAKDAHEQLAVADAKLGGVIKDKLNLSCIHSPMVTELMRGIRSQIEGLITGLPSREMAAMCLGLAHSLSRYKLKFSPDKVDTMIVQAISLLDDLDKELNNYIMRCREWYGWHFPELGKIITDNLTYCKCVRKVGDRRNFASSDVSDILPEEIEEDVKAAAEISMGTEVSEEDINNIIHLCDQVIEISEYRTQLYDYLKNRMMAIAPNLTVMVGELVGARLIAHAGSLLNLAKHPASTVQILGAEKALFRALKTKRDTPKFGLIYHASLVGQTTAKNKGKISRMLAAKTALTIRYDALGEDSSAEMGAENRLKVETRLRHLEERGIRRISGTGKALARADKYQNKSEIKVYDPSSDSTLPAVSKKRKIEEVEEQEAGVAVKAKKFKAEMKEEANVEEDEPVKKKKKKKEKKKQAEEEEDLTEEAPTSSTVENTEKKKKKKKKVKNENED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TUR8</accession>
    <name>A0A8C2TUR8_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="23">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">ATP2C2</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="21">ATP-driven pump that supplies the Golgi apparatus with Ca(2+) and Mn(2+) ions, both essential cofactors for processing and trafficking of newly synthesized proteins in the secretory pathway. Within a catalytic cycle, acquires Ca(2+) or Mn(2+) ions on the cytoplasmic side of the membrane and delivers them to the lumenal side. The transfer of ions across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing to outward-facing state. Induces Ca(2+) influx independently of its ATP-driven pump function. At the basolateral membrane of mammary epithelial cells, interacts with Ca(2+) channel ORAI1 and mediates Ca(2+) entry independently of the Ca(2+) content of endoplasmic reticulum or Golgi stores. May facilitate transepithelial transport of large quantities of Ca(2+) for milk secretion via activation of Ca(2+) influx channels at the plasma membrane and active Ca(2+) transport at the Golgi apparatus.</text>
    </comment>
    <comment type="function">
        <text evidence="23">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:18106"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>Mn(2+)(in) + ATP + H2O = Mn(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66820"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:66821"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="22">Interacts (via N-terminus) with ORAI1 (via N- and C-termini); this interaction regulates Ca(2+) influx at the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Basolateral cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="23">Membrane</location>
            <topology evidence="23">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 23">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="23"/>
    <dbReference type="RefSeq" id="XP_015729587.1">
        <property type="nucleotide sequence ID" value="XM_015874101.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TUR8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005025177.1">
        <property type="protein sequence ID" value="ENSCJPP00005018095.1"/>
        <property type="gene ID" value="ENSCJPG00005014722.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107319364"/>
    <dbReference type="CTD" id="9914"/>
    <dbReference type="GeneTree" id="ENSGT00940000160275"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032588">
        <property type="term" value="C:trans-Golgi network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140613">
        <property type="term" value="F:P-type manganese transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090280">
        <property type="term" value="P:positive regulation of calcium ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd02085">
        <property type="entry name" value="P-type_ATPase_SPCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000008">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000006">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000028">
        <property type="entry name" value="Calcium-transporting P-type ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006413">
        <property type="entry name" value="P-type_ATPase_IIA_PMR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01522">
        <property type="entry name" value="ATPase-IIA2_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 23" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 23" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 23" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="17 23" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="18 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 23" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-1278">Translocase</keyword>
    <keyword evidence="8 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 23" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="322"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="804"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="836"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="873"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="902"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="24">
        <location>
            <begin position="58"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00054616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00062966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005018095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="942" mass="103408" checksum="0FF145F75C85714F" modified="2022-01-19" version="1">MVEGVISKLLPKRPSARLTQKYQPLGSIEPEEESQECELKVIEQEKEVTVLLPKDACKYHKEDLAKALNVDLQTGLSEFSVLQRRMKHGWNEFSVDASEPIWKKYLDQFKNPLILLLLASALVSVITKEYEDAASITMAVLIVVTVAFIQEYRSEKSLEELNKLVPPECNCLREGKLQHLLARELVPGDIIYLSVGDRVPADLRLIEVTDLLVDESSFTGEAEPCNKTDGVLLEAGDITTLSNVVFMGTLVRYGKGKGVVIGTGENSQFGEVFKMMQAEETPKTPLQKSMDRLGKQLTLFSFGIIGLIMLIGWLQGKHLLSMFTIGVSLAVAAIPEGLPIVVTVTLVLGVLRMAKKRVIVKKLPIVETLGCCNVICSDKTGTLTANEMTVTRLVTSDGFQAEVSGVGYNGEGNVYLLPSKEILKEFSNVSVGKLVEAGCVVNNAVIRKNSVIGQPTEGALLALAMKMELADIRDIYARKKEIPFSSEQKWMAVKCTLKNQDQEDIYFMKGAFEEVIRYCTMYNSSGISLMLTPQQKASYQQEEKRMGSSGLRVLALASGSELGKLTFLGLVGIIDPPRAGVKEAVQVLVESGVSVKMITGDALETAVAIGQNIGLCNGKLKAMSGEELDQVEESELSSTVKNISIFFRTSPKHKLKIIKALQRAGAIVSMTGDGVNDAVALKSADIGIAMGQAGTDVSKEAANMILVDDDFSTVMNAIEEGKGIFYNIKNFVRFQLSTSISALSLITLSTVLNLPNPLNAMQILWINIIMDGPPAQSLGVEPVDRDTIKQPPRCITDTILSKSLILKIFMSALIIISGTLFVFWKENPTGGITPRTTTMTFTCFVFFDLFNALTCRSQTKLILEIGFFRNRMFLYSVLGSFLGQLAVIYVPPLQKIFQTENLGVLDLLFLTGLASSVFIVSELVKLCEKRCCHQKHSKEYRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TV01</accession>
    <name>A0A8C2TV01_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 16">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="12 16">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">USP13</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 12 16">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="12 16"/>
    <dbReference type="RefSeq" id="XP_015727003.1">
        <property type="nucleotide sequence ID" value="XM_015871517.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TV01"/>
    <dbReference type="Ensembl" id="ENSCJPT00005024327.1">
        <property type="protein sequence ID" value="ENSCJPP00005017463.1"/>
        <property type="gene ID" value="ENSCJPG00005014247.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107318115"/>
    <dbReference type="KEGG" id="cjo:107318115"/>
    <dbReference type="CTD" id="8975"/>
    <dbReference type="GeneTree" id="ENSGT00940000157401"/>
    <dbReference type="OrthoDB" id="361536at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904288">
        <property type="term" value="F:BAT3 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:1990380">
        <property type="term" value="F:K48-linked deubiquitinase activity"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
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    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:protein stabilization"/>
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        <property type="term" value="P:regulation of DNA-templated transcription"/>
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    <dbReference type="CDD" id="cd02658">
        <property type="entry name" value="Peptidase_C19B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UBA1_UBP13"/>
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        <property type="entry name" value="UBA2_UBP5"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
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    <dbReference type="FunFam" id="3.30.40.10:FF:000026">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
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    </dbReference>
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        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="UV excision repair protein RAD23 homolog"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
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    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
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        <property type="entry name" value="UBA"/>
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        <property type="entry name" value="UBA-like_sf"/>
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        <property type="entry name" value="Ubiquitinyl_hydrolase"/>
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        <property type="entry name" value="UBP13_Znf-UBP_var"/>
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        <property type="entry name" value="USP"/>
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    <dbReference type="InterPro" id="IPR018200">
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        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
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        <property type="entry name" value="Znf_UBP"/>
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    <dbReference type="PANTHER" id="PTHR21646">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF105">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 13"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00627">
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    <dbReference type="Pfam" id="PF17807">
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    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RING/U-box"/>
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        <property type="entry name" value="ZF_UBP"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8 12 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 12 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 12 16" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 12 16" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="7 12 16" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10 12 14" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="19">
        <location>
            <begin position="182"/>
            <end position="290"/>
        </location>
    </feature>
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        <location>
            <begin position="331"/>
            <end position="860"/>
        </location>
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        <location>
            <begin position="647"/>
            <end position="688"/>
        </location>
    </feature>
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        <location>
            <begin position="722"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="13">
        <location>
            <position position="340"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="822"/>
        </location>
    </feature>
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        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
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        <location>
            <position position="209"/>
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        <ligand>
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        </ligand>
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        <location>
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        </ligand>
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        <location>
            <position position="239"/>
        </location>
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            <name>Zn(2+)</name>
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        </ligand>
    </feature>
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            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="862" mass="96719" checksum="D7945C9C52753CC4" modified="2022-01-19" version="1">MQRAALFGGGDAQMAAGDLGELLVPYMPTIRVPKSGDRVYKTECAFSYDSPDSEGGLYVCMNTFLGFGREHIERHYRKTGQCVYLHLKRRVIEKVPGASGGALPKRRNAKLFLDLEANGDLSGDDFEYEDEAKLVIFPDHYEISLPNIEELPALVTIASDALLSAKSPYRKQEPDSWEEELQASKHAKSLVQLDNGVRIPPSGWKCSKCDLRENLWLNLTDGSVLCGKWFFDGRGGNGHALEHYKETGYPLAVKLGTITPDGADVYSFDEEEPVLDPHIAKHLAHFGIDMLQMQVTENGLRDNDIKPRVSEWEVIQEAGVKLKPMYGPGYTGMKNLGNSCYLNAVMQAIFSIPEFQRAYVGNLPRIFDYSPIDPTQDFNTQMAKLGHGLLSGQYSKPPMKSELIEQVMKEEHKPQQNGISPQMFKAFISKDHTEFSSNRQQDAQEFFLHLINLVERNPVGSENPSDVFRFLVEERTQCCQSRKVRYTERVDCIMQLPVAMEAATNKDELIAYELKRREAEAARRPPPELVRAKIPFSACLQAFSEPSNVEDFWSSALQAKSAGVKTSRFASFPQYLVVQIKKFTFGLDWIPKKLDVSIDMPDFLDINHLRATGLQPGEEELPDIAPPIVIPEDPKDRMVNHFVESLDIDESSVMQLAEMGFPLEACRKAVYYTGNLGAEVAFNWIIAHMEEPDFAEPLVVPVFGGAASSGMAGLGAVGLDNQPPEEMVSIIISMGFQRSLAIRALKATNNNLERALEWIFSHPELEEEDGEPALNMMDLENHTNANILAETRSEGPRIKDGPGRYELLGFISHMGTSTMSGHYVCHLKKEGRWVIYNDLKVCASERPPKDLGYIYFYHRIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TW65</accession>
    <name>A0A8C2TW65_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NOTCH regulated ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">NRARP</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the NRARP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015734324.1">
        <property type="nucleotide sequence ID" value="XM_015878838.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TW65"/>
    <dbReference type="Ensembl" id="ENSCJPT00005027035.1">
        <property type="protein sequence ID" value="ENSCJPP00005019531.1"/>
        <property type="gene ID" value="ENSCJPG00005015819.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107321679"/>
    <dbReference type="KEGG" id="cjo:107321679"/>
    <dbReference type="CTD" id="441478"/>
    <dbReference type="GeneTree" id="ENSGT00940000161928"/>
    <dbReference type="OrthoDB" id="5314041at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004857">
        <property type="term" value="F:enzyme inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019208">
        <property type="term" value="F:phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002043">
        <property type="term" value="P:blood vessel endothelial cell proliferation involved in sprouting angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001569">
        <property type="term" value="P:branching involved in blood vessel morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045746">
        <property type="term" value="P:negative regulation of Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045581">
        <property type="term" value="P:negative regulation of T cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090263">
        <property type="term" value="P:positive regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905564">
        <property type="term" value="P:positive regulation of vascular endothelial cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032525">
        <property type="term" value="P:somite rostral/caudal axis specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030217">
        <property type="term" value="P:T cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101023">
        <property type="term" value="P:vascular endothelial cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000085">
        <property type="entry name" value="Notch-regulated ankyrin repeat-containing protein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051226">
        <property type="entry name" value="PP1_Regulatory_Subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24179:SF21">
        <property type="entry name" value="MYOSIN BINDING SUBUNIT, ISOFORM O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24179">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="50"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005019531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="114" mass="12438" checksum="C65A5465B1D33E9A" modified="2022-01-19" version="1">MSHSDVSPCAAPPSQRVFQEAVRRGNTKELQSLLQNMTNCEFNVNSFGPEGQTALHQSVIDGNLELVKLLVKFGADIRLANRDGWSALHIAAFGGHQDIVLYLITKAKYSAGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TW74</accession>
    <name>A0A8C2TW74_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">RLF zinc finger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">RLF</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015738893.1">
        <property type="nucleotide sequence ID" value="XM_015883407.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005027369.1">
        <property type="protein sequence ID" value="ENSCJPP00005019790.1"/>
        <property type="gene ID" value="ENSCJPG00005016014.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107323901"/>
    <dbReference type="KEGG" id="cjo:107323901"/>
    <dbReference type="CTD" id="6018"/>
    <dbReference type="GeneTree" id="ENSGT00950000183034"/>
    <dbReference type="OrthoDB" id="8691423at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052251">
        <property type="entry name" value="GH-ZnFinger_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057986">
        <property type="entry name" value="TPR_Rlf/292/654"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058902">
        <property type="entry name" value="zf_C2H2_ZNF292/Rlf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15507">
        <property type="entry name" value="ZINC FINGER PROTEIN RLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15507:SF18">
        <property type="entry name" value="ZINC FINGER PROTEIN RLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25580">
        <property type="entry name" value="TPR_Rlf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25420">
        <property type="entry name" value="zf-C2H2_ZN292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26218">
        <property type="entry name" value="zf_C2H2_ZNF292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="554"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="649"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="692"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="720"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="749"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="1161"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="1303"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="1355"/>
            <end position="1385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="595"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="823"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="976"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1239"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1591"/>
            <end position="1650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1682"/>
            <end position="1702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1799"/>
            <end position="1818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="832"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="989"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1000"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1244"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1591"/>
            <end position="1614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1624"/>
            <end position="1635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1807"/>
            <end position="1816"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005019790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1902" mass="216902" checksum="81E08C6CDA9F8255" modified="2022-01-19" version="1">MADAEAEAAPRAEMARLVAALRGRLWQLQTELCEQEVSEASSRAYCRGFCQTLLHYAGSRGASEHILPFLEVYRISIQSFANARPYLTTECEDVLLVLGRLVLSCFELLLSIPESELPHEVWVEFHQSIQDSHDALLEFGNNNLQVLVDITREGVWKNPVLMKILSQQPVETEEANKLITREGPSFLQMRIKHLMKSNCIPQATSLSKLCADSPDIANVASFRQAYITCVCSMLPNEDSIKEIAKVDCKEVLDIICNLESEGQENTAFILCTTYLTHQLQTANVYCSWELTLFWSKLQRRIDPSLDSFLERCRQFGIIAKTLQHLFFLIRVIQSEAEEAGLAVSVLLCVRALQIRSNGSDEMKTSVCKTIACLLPEDLEVRRACQLTEFLLEPTLSGFNMLEELYMQPDQKFDEENALVPNSLRCELLLALKAYWPFDPEFWDWKTLKRHCLKLLGKAGSDSEDDASCNMSINETDMLETFFSDYDEAKDHKYYDGKDPINYHKEKARVKKPIGSSERYQRWLQYKFFCVLCKRECIEARILHHSKMHMEDGIYTCPVCTKKFKRKEFFVPHVMEHVKMPPSRTHRPKKKIILKKERSPQKIAAPVSPTSTSQEKSHQPELSEDFGNDTQEYVTFSQLENCQLQDRDIYPCPGTDCSRVFKQFKYLSVHLKAEHQNNDENAKHYLDMKNRREKCAFCRRHFMTSFHLREHERVHCGPQPYMCVSMDCYARFGSVNELLNHKQTHEDLRYKCELNGCNIVFSDLGQLYHHEAQHFRDASYTCNFFGCKKFYYSKTEFQNHLAVHNIAVSNGEVKQTVKLEESQLLEQSESSHQNETLDSTGSEEIPQIKEEALSDSEDLDSESNCSLHCGNRSGTASVNEGQVPPLLIETLAHGQTVPGFLMSQEGVFHSADVKQQCSDAAVCFDEKKFSCGFEGCCSAHKNSRSVHKHLRRAHPYNFKGKKGMEVKTKDVLDLLNDAPESQSPTDDSTELGHKSDRNTDSPENSYCNINAKGNNSFKEETYPSSPETSFYDSSRESNIEDNMLELMLGLKHLSLKNSNIQSSSRSKRVLGSLQSCSSRDTKCPESGVDATTSKLQFQEQQDNLPSQYLTQLAAKPFFCECQGCTCEFVTREALLMHYVKKHNYSKEMVLQLNMFQHRYSPFKCHICQRSFTRKTHLRIHYRNKHQIGCEQVAHKVCSGEKMDHVGLCSDNVHKNSAVSTPVCPTKVEYVDRSEQRCHPKKEECSSETDLESGEEMDGNIRKSSKIATLDGHREELEAREGRGSKRTVAKGNLCYILHKYHKPFHCIHKSCNSAFTNQKGLIRHYRTVHQYNKEQVCLEKDKAGSKRELVKCKKIFACKHKECGKRFFCSKDLAKHCSDFHNEQLDDQKLLAGTESVRFACNQAQCPAVFCTFPELKQHLIEEHANGEKINKDFEIHCDLNGCNRIFTNYSHYSQHVYFRHSEYYNDLFGNQKEEQDNHDKSKGGQGCVRGGFGLSKQIRKEIKEKPKRPSRSKDKHLLTFKTKEEALQMCQENSNQTQYPCMVVGCLSVVKLESSILRHYKRTHQMTNVYIEQRLQNLVLCVKCGTMTEKRSCSEPASDMDKKDVEVKEEKPADPECPQETEKSLVSNTDCQHQDVSSEEQNRCPSSSESFNTSAFTYSGTLDCNHGSKSSCLEEHNVRESVAGNTEELSENSEKENSSCLSGLQLELPREKETEGCDNSAVNQNAKRNAVFAAKDKFQKPPVSRPFDLKTYKPMGFESSFLKFIQESEGKDDDDDDDFDEVVEWESPEQLPVDRALQNEGEGQKDSPPNSCTSGDKSVIVPQSDDGQLAEMQPLLAEPSSAPSLENLRAILDKALTGCGDLALKQLHYLRPVVVLERSKFSTALIDLFPTKKADELCVGSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TY31</accession>
    <name>A0A8C2TY31_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyridoxal phosphate homeostasis protein</fullName>
            <shortName evidence="2">PLP homeostasis protein</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Proline synthase co-transcribed bacterial homolog protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">PLPBP</name>
        <name evidence="2" type="synonym">PROSC</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TY31"/>
    <dbReference type="Ensembl" id="ENSCJPT00005025927.1">
        <property type="protein sequence ID" value="ENSCJPP00005018663.1"/>
        <property type="gene ID" value="ENSCJPG00005015174.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000004928"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06822">
        <property type="entry name" value="PLPDE_III_YBL036c_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.10:FF:000007">
        <property type="entry name" value="Pyridoxal phosphate homeostasis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02087">
        <property type="entry name" value="PLP_homeostasis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011078">
        <property type="entry name" value="PyrdxlP_homeostasis"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00044">
        <property type="entry name" value="YggS family pyridoxal phosphate-dependent enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146">
        <property type="entry name" value="PROLINE SYNTHETASE CO-TRANSCRIBED BACTERIAL HOMOLOG PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146:SF14">
        <property type="entry name" value="PYRIDOXAL PHOSPHATE HOMEOSTASIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004848">
        <property type="entry name" value="YBL036c_PLPDEIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alanine racemase N-terminal" evidence="6">
        <location>
            <begin position="39"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="251"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2 3">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR004848-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005018663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="277" mass="29932" checksum="96C06E1517B75037" modified="2022-01-19" version="1">GMWRAAMAAGEGLGPALRAVTEQVLQAAARRPQGLPAVQPRLVAVSKTKPAEMVLDAYSHGQRSFGENYVQELLEKASDSRILSSCPEIKWHFIGHLQKSNVNKLIAVPNLFMLETVDSVKLADKVNSSWQKKGSPQKLKVMVQVNTSGEDSKHGLPPRDTAAAVEHIINKCPSLEFVGLMTIGSIGHDLSKGPNPDFQVLLSLRKEVCEKLNLPIEKVELSMGMSTDFQHAIEVGSTNVRIGSTIFGERDYSNKADGGKAPAETKGKTEASTALGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TZA8</accession>
    <name>A0A8C2TZA8_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Tubulin gamma complex component 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">TUBGCP3</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TUBGCP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015704665.1">
        <property type="nucleotide sequence ID" value="XM_015849179.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TZA8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005027128.1">
        <property type="protein sequence ID" value="ENSCJPP00005019611.1"/>
        <property type="gene ID" value="ENSCJPG00005015884.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107306225"/>
    <dbReference type="KEGG" id="cjo:107306225"/>
    <dbReference type="CTD" id="10426"/>
    <dbReference type="GeneTree" id="ENSGT00940000157872"/>
    <dbReference type="OrthoDB" id="5860513at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005827">
        <property type="term" value="C:polar microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF14">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="8">
        <location>
            <begin position="251"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="555"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="216"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="216"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005019611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="907" mass="103662" checksum="E05F2F45047A636F" modified="2022-01-19" version="1">MATPDQKSPNVLLQNLCCRILGKSEADVAQQFQYAVRVIGSNFAPTVERDEFLVAEKIKKELVRQRREADAALFSELYRKLGSQGILKNKWAILYLLLSLSEDPRKQSNKVSSYATLFAQALPRDAHSTPYYYARPQSLPLNYQDRSAQSAQSSGSMGSSGISSINLYALNGPTPTPQSLLPGQSYQAPSVGDCLRQQLGSRLAWTLTASQPSLQNTTSKGFSNAVSRGVPRSRREGDTSGSVEITEANLVRDVLYVFQGIDGKNIKMCNSENCYKVEGKVSLSKSLRDTTSRLAELGWLHNKIRKYTDQRSLDRAFGLVGQSFCAALHQELKEYYRLLSVLHSQLQLEDDQGVNLGLESSLTLRRLLVWTYDPKIRLKTLAALVDHCQGRKGGELASAVHAYTKTGDPYMRSLVQHILGLVSHPVLNFLYRWIYDGELEDTYHEFFVASDPTVKTDRLWHDKYTLRKSMIPSFITMEQSKKVLLIGKSINFLHQVCHDQTPSTKMIAVAKSAESSKGAADLFTDLENAFQEKIDAAYFETSKYLLDVLNKKYNLLEHMQAMRRYLLLGQGDFIRHLMDLLKPELARPATTLYQHNLTGILETAVRATNAQFDNPEILKRLDVRLLEVSPGDTGWDVFSLDYHVDGPIATVFTRECMSHYLRVFNFLWRAKRMEYILTDIWKGHMCNAKLLKSMPELSGVLHQCHVLASEMVHFIHQMQYYITFEVLECSWDELWNKVQQAQDLDHIIAAHEVFLDTIIARCLLDSDSRVLLNQLRAVFDQIIELQNAQDAMYRAALEELQLRLQFEERKKQRELEGKWGVTASEEEEEKKRIKEFQDSIPKMCSQLRILTHFYQGIVQQFLVLLTTSSDESLRFLSFRLDFNEHYKAREPRLRVSLGVRGKRSSHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U097</accession>
    <name>A0A8C2U097_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cysteine-rich tail protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U097"/>
    <dbReference type="Ensembl" id="ENSCJPT00005027062.1">
        <property type="protein sequence ID" value="ENSCJPP00005019552.1"/>
        <property type="gene ID" value="ENSCJPG00005015839.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00960000191971"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018904">
        <property type="entry name" value="UPF0574"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10631">
        <property type="entry name" value="DUF2477"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005019552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="136" mass="15152" checksum="65D6C07E2E040013" modified="2022-01-19" version="1">RDPRETDGDMDRGVTLENPYASVNIPRSQFQQSFITRYLEDEPASPTVIANPAVVPVYSTEEQAGSWDKQPISTEKSWSRPYNPYASMKMPNGESPNSFYTVTLDKPPKGHGHEDGGRSGCRRCCPCCRKCCCVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U136</accession>
    <name>A0A8C2U136_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2 8">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">FKBP7</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 8"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2U136"/>
    <dbReference type="Ensembl" id="ENSCJPT00005029784.1">
        <property type="protein sequence ID" value="ENSCJPP00005021718.1"/>
        <property type="gene ID" value="ENSCJPG00005017345.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159964"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000006">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052273">
        <property type="entry name" value="PPIase_FKBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46222:SF2">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46222">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP7/14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8" id="KW-0697">Rotamase</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034327214" description="peptidylprolyl isomerase" evidence="9">
        <location>
            <begin position="24"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="10">
        <location>
            <begin position="48"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005021718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="148" mass="15817" checksum="E8467DAA79555CB4" modified="2022-01-19" version="1">MSPGLSLILAALVLLAASERAEGSAAEEEVKIEVLHLPESCSPKSKKGDLLNAHYDGFLASNGSKFYCSRTQNDGHPKWFVLGVGQVIKGLDIAMMNMCPGEKRKVVIPPSLAYGQQGYGSTSRNCSVSATYLSSVSAYSCMLRKMPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U1Y6</accession>
    <name>A0A8C2U1Y6_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="30 31">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="30" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="30" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="30" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="26">Membrane</location>
            <topology evidence="26">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="26">Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2U1Y6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005029182.1">
        <property type="protein sequence ID" value="ENSCJPP00005021230.1"/>
        <property type="gene ID" value="ENSCJPG00005016989.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000166132"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019838">
        <property type="term" value="F:growth factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005021">
        <property type="term" value="F:vascular endothelial growth factor receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001525">
        <property type="term" value="P:angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045446">
        <property type="term" value="P:endothelial cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045766">
        <property type="term" value="P:positive regulation of angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043408">
        <property type="term" value="P:regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:002412">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000041">
        <property type="entry name" value="Vascular endothelial growth factor receptor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000143">
        <property type="entry name" value="Vascular endothelial growth factor receptor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001824">
        <property type="entry name" value="Tyr_kinase_rcpt_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041348">
        <property type="entry name" value="VEGFR-2_TMD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF552">
        <property type="entry name" value="RECEPTOR PROTEIN-TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21339">
        <property type="entry name" value="VEGFR-1-like_Ig-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17988">
        <property type="entry name" value="VEGFR-2_TMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000615">
        <property type="entry name" value="TyrPK_CSF1-R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00240">
        <property type="entry name" value="RECEPTOR_TYR_KIN_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0037">Angiogenesis</keyword>
    <keyword evidence="12 22 25" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="18" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="19 26" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="23" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="23" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 22 25" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17 26" id="KW-0675">Receptor</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 26" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="15" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="Ig-like" evidence="29">
        <location>
            <begin position="264"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="29">
        <location>
            <begin position="355"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="28">
        <location>
            <begin position="526"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="664"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="21">
        <location>
            <position position="722"/>
        </location>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <begin position="533"/>
            <end position="540"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22 25">
        <location>
            <position position="560"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="726"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="727"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="740"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for interaction with phosphotyrosine-binding proteins" evidence="24">
        <location>
            <position position="867"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="RuleBase" id="RU000311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005021230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1003" mass="111756" checksum="45070EEE74F06E48" modified="2022-01-19" version="1">MVGKGMVLQISVLLSADYRNPFVEFHPEHPKIIYILEAKKTVVIPCRVTSPDIRPKLFQYPHPVEINFKKMLWDPKRGFVIPSHAYSGVLTCTANINGSVFTSYYLVQKLGESFTWSCNSVTVPDLCSQIALPGCCSFSCFQLLHICNCKRSRIGTALCKDMSTALWQICHSLSSSLFLFQDKPFLEVSHKKGLYYEITSGHKSLKLSAKVDAFPPFTFSLFAWQIVSTLTMENSSTSGIYYCVASNKIGEEERSIEFYVSDVPSGLQTAPQVTAIAGSTAKLTCRASRYIYSNLAWSYPSLGAAHGGSLTRSADAYSISLTLVIANVTEEHSGLYKCRAHTNTGLLPVSLKAAPYVLQNLTDLEVNISGKIILECRVSGTPEPQVTWSKDGYPISAASGESLIAGISMENNTLVIERVKKDDEGLYECKATNDMGQDSTSAFIKIQGSEEKSNIEVIILVCTGLAATLFWLLLTLFIRKLRKPDATDIKTGYLSIIMDPEEMPLDEQCDRLPYDSSKWEFPRDRLRLGKTLGHGAFGKVVEASAFGIDKSSTCKTVAVKMLKECATTNECKALMSELKILIHIGHHLNVVNLLGACTKAGGPLMVIVEYCKYGNLSNYLRGKRGDFIAYKENSGQAEKSLDESSSDLTELIKRRLESVASTGSSASSGFIEDKSYSDSEEDEEDAEDLYKRPLTLEDLICYSFQVAKGMEFLASRKCIHRDLAARNILLSENNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPEAIFDKIYTTQSDVWSFGVLLWEIFSLGASPYPGVQIDEDFCRRLKEGTRMRSPEYSTPEVYQTMLDCWHGVPTERPTFTELVERLGDLLQANVQQVHYQCLSGPHSAPQLSCSSSSKRRPLSVKTFDEVSVGKEKVMHEVSGATTGLYKNLWRWDQYIILLILNRRRAVSKSKESILSDHEREAVKYQPAVQVEEDTMDFPLEDSVLLPMDPSLECHSPPPDYNSVVHCSAPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U2Q4</accession>
    <name>A0A8C2U2Q4_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="22">Gamma-aminobutyric acid receptor subunit beta-4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">LOC107312849</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Postsynaptic cell membrane</location>
            <topology evidence="17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015716127.1">
        <property type="nucleotide sequence ID" value="XM_015860641.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U2Q4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005028965.1">
        <property type="protein sequence ID" value="ENSCJPP00005021053.1"/>
        <property type="gene ID" value="ENSCJPG00005016866.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107312849"/>
    <dbReference type="KEGG" id="cjo:107312849"/>
    <dbReference type="GeneTree" id="ENSGT00940000164188"/>
    <dbReference type="OrthoDB" id="8890589at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902711">
        <property type="term" value="C:GABA-A receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004890">
        <property type="term" value="F:GABA-A receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18999">
        <property type="entry name" value="LGIC_ECD_GABAAR_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19053">
        <property type="entry name" value="LGIC_TM_GABAAR_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000004">
        <property type="entry name" value="Gamma-aminobutyric acid receptor subunit beta-2 isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000004">
        <property type="entry name" value="Gamma-aminobutyric acid receptor subunit beta-2 isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002289">
        <property type="entry name" value="GABAAb_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01160">
        <property type="entry name" value="GABAARBETA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0868">Chloride</keyword>
    <keyword evidence="11" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16 18" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 18" id="KW-0406">Ion transport</keyword>
    <keyword evidence="15" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 18" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 18" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034274042" evidence="18">
        <location>
            <begin position="26"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="271"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="308"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="469"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="20">
        <location>
            <begin position="37"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="21">
        <location>
            <begin position="249"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="338"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005021053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="488" mass="56086" checksum="1F32BD98EECC9B89" modified="2022-01-19" version="1">MWTFQADRLSGIVSALAALCVACCAQSPSTGNISVVKEIVDKLLKGYDVRLRPDFGGNPVTVGMSIHISSIDQISEVNMDYTITMYFQQSWRDKRLAYNDLPLNLTLDNRVADQLWVPDTYFLNDKKSFLHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDQQNCTLEIESYGYTVDDIVFFWQGNDSAVTGMEVLELPQFTIIEQRLVSREVVFTTGSYLRLSLSFRIKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGVTTVLTMTTINTHLRETLPKIPYVKAIDVYLMGCFVFVFLALLEYAFVNYIFFGRGPRQQKKQSERISKANNERHRYEEKRVREQVDPYGNILLSTLDMNNELLATDMMSSVGDSRNSVMSFEGSGIQFRKQLASRDGFGHHPTLDRHVPLTHHAAARNRANCRLRRRSSKLKLKIPDLTDVSTIDKWSRIIFPITFGFFNLVYWLYYVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U3U1</accession>
    <name>A0A8C2U3U1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Centrosomal protein of 97 kDa</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Leucine-rich repeat and IQ domain-containing protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">CEP97</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as a key negative regulator of ciliogenesis in collaboration with CCP110 by capping the mother centriole thereby preventing cilia formation. Required for recruitment of CCP110 to the centrosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015732739.1">
        <property type="nucleotide sequence ID" value="XM_015877253.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U3U1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005030225.1">
        <property type="protein sequence ID" value="ENSCJPP00005022046.1"/>
        <property type="gene ID" value="ENSCJPG00005017615.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107320919"/>
    <dbReference type="KEGG" id="cjo:107320919"/>
    <dbReference type="CTD" id="79598"/>
    <dbReference type="GeneTree" id="ENSGT00910000144283"/>
    <dbReference type="OrthoDB" id="5954088at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030030">
        <property type="term" value="P:cell projection organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902018">
        <property type="term" value="P:negative regulation of cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901673">
        <property type="term" value="P:regulation of mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000165">
        <property type="entry name" value="Centrosomal protein of 97 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050576">
        <property type="entry name" value="Cilia_flagella_integrity"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973:SF2">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 97 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT SDS22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="313"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="445"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="729"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="776"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="578"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="445"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="748"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="776"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="798"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="814"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00058656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00068862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00076677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005022046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="870" mass="95986" checksum="11AACF5F9391FE70" modified="2022-01-19" version="1">MAATGAEERNEPGSSAAGGLVVNWSGQGLQKLGPTLPCDPDTHTLILDKNQIIKLEHLEKCRNLMQLSVANNRLVRMMGVAKLTQLRVLNLPHNSIGYVEGLKELVHLEWLNLAGNNLKAIEQMNSCASLQHLDLSDNNISQLGDLSKLTSLKTLLLHGNIITSLRTAPVCLPHNLTVFSLAENEIRDLNEVSFLASLPQLEQLSIMNNPCVMATPSVPGFDYRPYIVSWCLNLKVLDGYMVSQKESLKAEWLYSQGKGRSYRPGQHVQLVQYLATVCPLISTYGLQTEEDAKLEKILSKQRLHQRQLMCQNQNEGPATSASNRTLPVTSEHSSPVHPPQIVLESERVIQKNSWVGPSVNDDHSYAVKNTFLHERNCRKELYLEDVQTDEDKLNSSLLSSESTFMPVASGLSPASPTSEPKLCGISLDLEDNDSTVLEFAKDANRRETVNKQEESSWLTKEHSNKVTESAETQEQMKERVQLSSSDLVKANQTDAGNSSASSEDQLLHGQPGTELRVTTVCTEKVAGENLDSLAAVDRGADELQRMTKAATKLQACWRGFYTRNYHPRAKEVRYEIRLSRMQEHILCLTDEIQKLRKEREEDKIQRLVQEEAVRFVWNQVKSLQQWQLTVTQHLGTTCQPGIPSAGTSCLSEPSTQTSTLEQETPSDVSSACLAPAGDVLQEKPLLQFPDSGFHSAMADQTHTGDLCTDEKSLTEGTEGSLSVETIKQCGNSASERSSDVEDDGGGCEQSTESSNNEQDNRLLQQYLESVEQLVEADEGTNCNDEGEEGGWPQVDISAESQDSSSDLLSVGIPQGTSSPARGEMNQTPDSCKLDSGIENRIESLLCKEKNLMKEDESSCLSELLTTASVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U5B3</accession>
    <name>A0A8C2U5B3_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Diamine acetyltransferase 1</fullName>
            <ecNumber evidence="5">2.3.1.57</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Polyamine N-acetyltransferase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Putrescine acetyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Spermidine/spermine N(1)-acetyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">SAT1</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>an alkane-alpha,omega-diamine + acetyl-CoA = an N-acetylalkane-alpha,omega-diamine + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11116"/>
            <dbReference type="Rhea" id="RHEA-COMP:9766"/>
            <dbReference type="Rhea" id="RHEA-COMP:9767"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:70977"/>
            <dbReference type="ChEBI" id="CHEBI:70988"/>
            <dbReference type="EC" id="2.3.1.57"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:11117"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>spermidine + acetyl-CoA = N(1)-acetylspermidine + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28150"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
            <dbReference type="ChEBI" id="CHEBI:58324"/>
            <dbReference type="EC" id="2.3.1.57"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:28151"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>spermine + acetyl-CoA = N(1)-acetylspermine + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33099"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:45725"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58101"/>
            <dbReference type="EC" id="2.3.1.57"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:33100"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amine and polyamine degradation; putrescine degradation; N-acetylputrescine from putrescine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.57" evidence="5"/>
    <dbReference type="RefSeq" id="XP_015741074.1">
        <property type="nucleotide sequence ID" value="XM_015885588.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U5B3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005029614.1">
        <property type="protein sequence ID" value="ENSCJPP00005021570.1"/>
        <property type="gene ID" value="ENSCJPG00005017262.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107325080"/>
    <dbReference type="CTD" id="6303"/>
    <dbReference type="GeneTree" id="ENSGT00950000183121"/>
    <dbReference type="OrthoDB" id="7305308at2759"/>
    <dbReference type="UniPathway" id="UPA00188">
        <property type="reaction ID" value="UER00363"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004145">
        <property type="term" value="F:diamine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019809">
        <property type="term" value="F:spermidine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001525">
        <property type="term" value="P:angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006596">
        <property type="term" value="P:polyamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009447">
        <property type="term" value="P:putrescine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042127">
        <property type="term" value="P:regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032918">
        <property type="term" value="P:spermidine acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000011">
        <property type="entry name" value="Diamine acetyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051016">
        <property type="entry name" value="Diverse_Substrate_AcTransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545:SF36">
        <property type="entry name" value="DIAMINE ACETYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545">
        <property type="entry name" value="DIAMINE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="16">
        <location>
            <begin position="4"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005021570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="171" mass="19949" checksum="C7B8C383B1C15B2E" modified="2022-01-19" version="1">MASFSIRAARPEDCSDLLRLIKELAKYEDMEDQVVLTEKELLEDGFGEHPFYHCLVAEVPKEQWSAEGHSIVGFAMYYFTYDPWIGKLLYLEDFYVMAEYRGLGIGSEILKNLSQVAVKCRCSSMHFLVAEWNEPSIRFYKRRGASDLSTEEGWRLFKIDKEYLLKMATEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U6F5</accession>
    <name>A0A8C2U6F5_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Growth hormone-releasing hormone receptor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Growth hormone-releasing factor receptor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC107325042</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015741010.1">
        <property type="nucleotide sequence ID" value="XM_015885524.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U6F5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005033060.1">
        <property type="protein sequence ID" value="ENSCJPP00005024227.1"/>
        <property type="gene ID" value="ENSCJPG00005019129.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107325042"/>
    <dbReference type="KEGG" id="cjo:107325042"/>
    <dbReference type="GeneTree" id="ENSGT00940000166534"/>
    <dbReference type="OrthoDB" id="5967113at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016520">
        <property type="term" value="F:growth hormone-releasing hormone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017046">
        <property type="term" value="F:peptide hormone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004999">
        <property type="term" value="F:vasoactive intestinal polypeptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051240">
        <property type="term" value="P:positive regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040008">
        <property type="term" value="P:regulation of growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd15271">
        <property type="entry name" value="7tmB1_GHRHR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1240.10:FF:000014">
        <property type="entry name" value="Growth hormone-releasing hormone receptor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000032">
        <property type="entry name" value="Vasoactive intestinal polypeptide receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.10">
        <property type="entry name" value="GPCR, family 2, extracellular hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050332">
        <property type="entry name" value="GPCR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036445">
        <property type="entry name" value="GPCR_2_extracell_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001879">
        <property type="entry name" value="GPCR_2_extracellular_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017983">
        <property type="entry name" value="GPCR_2_secretin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001771">
        <property type="entry name" value="GPCR_2_VIP_rcpt_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620:SF16">
        <property type="entry name" value="GROWTH HORMONE RELEASING HORMONE RECEPTOR 2 PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620">
        <property type="entry name" value="PDF RECEPTOR-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02793">
        <property type="entry name" value="HRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01154">
        <property type="entry name" value="VIP1RECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00008">
        <property type="entry name" value="HormR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111418">
        <property type="entry name" value="Hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00650">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50227">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 17" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034382811" description="Growth hormone-releasing hormone receptor" evidence="17">
        <location>
            <begin position="26"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="219"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 1" evidence="18">
        <location>
            <begin position="42"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="19">
        <location>
            <begin position="140"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00055347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00071070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00079039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005024227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="422" mass="48150" checksum="8BA390EC88584A33" modified="2022-01-19" version="1">MGCPRLNSGSCVLLLLMLPVLQVRATHPDCSIILYFQERENECLEAIRSESQTQPPNGQRGCRTAWDGVSCWPAMPVGQSYAVACPDVPHIFKKSQVLIHRNCTEVGWSPPSPPYYSACELEPVGSSNNTEAKRGYFITMKVLYTCGYSTSLAALFMAIGIFSCFRKLHCTRNSIHIHFFTSFILRGASVLIKDAVLFSDESVDHCTMSTVKCKASIAFVQYSVLANFFWLLVEGMYLQTLLLLTFTSDRSYIWWYILIGWGVPVLTVCVWVFTRLQYDDHGCWDDYSSPYWWVIKAPILLAIFVNFLIFLNVTRMLAQKIRSPDISKNHKQQYMRLTKSTLLLIPLFGVHYVVFALFPEHIGVDARLYFELVLGSYQGFLVALLYCFLNGEVQAEIKRNWGKWQTSMESNVFNMATQDFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U6J8</accession>
    <name>A0A8C2U6J8_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LDL receptor related protein associated protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LRPAP1</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015718375.1">
        <property type="nucleotide sequence ID" value="XM_015862889.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U6J8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005032066.1">
        <property type="protein sequence ID" value="ENSCJPP00005023397.1"/>
        <property type="gene ID" value="ENSCJPG00005018568.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107314029"/>
    <dbReference type="KEGG" id="cjo:107314029"/>
    <dbReference type="CTD" id="4043"/>
    <dbReference type="GeneTree" id="ENSGT00390000004855"/>
    <dbReference type="OrthoDB" id="5817428at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048237">
        <property type="term" value="C:rough endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035473">
        <property type="term" value="F:lipase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050750">
        <property type="term" value="F:low-density lipoprotein particle receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048019">
        <property type="term" value="F:receptor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048018">
        <property type="term" value="F:receptor ligand activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070326">
        <property type="term" value="F:very-low-density lipoprotein particle receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0150093">
        <property type="term" value="P:amyloid-beta clearance by transcytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900222">
        <property type="term" value="P:negative regulation of amyloid-beta clearance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002091">
        <property type="term" value="P:negative regulation of receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010916">
        <property type="term" value="P:negative regulation of very-low-density lipoprotein particle clearance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd14806">
        <property type="entry name" value="RAP_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14807">
        <property type="entry name" value="RAP_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14808">
        <property type="entry name" value="RAP_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.81.10">
        <property type="entry name" value="RAP domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038003">
        <property type="entry name" value="A2-macroglobuin_RAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010483">
        <property type="entry name" value="Alpha_2_MRAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009066">
        <property type="entry name" value="MG_RAP_rcpt_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038001">
        <property type="entry name" value="RAP_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037999">
        <property type="entry name" value="RAP_D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036744">
        <property type="entry name" value="RAP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16560">
        <property type="entry name" value="ALPHA-2-MACROGLOBULIN RECEPTOR-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16560:SF2">
        <property type="entry name" value="ALPHA-2-MACROGLOBULIN RECEPTOR-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06401">
        <property type="entry name" value="Alpha-2-MRAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06400">
        <property type="entry name" value="Alpha-2-MRAP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47045">
        <property type="entry name" value="RAP domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034845700" evidence="1">
        <location>
            <begin position="23"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-2-macroglobulin receptor-associated protein" evidence="2">
        <location>
            <begin position="9"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-2-macroglobulin RAP C-terminal" evidence="3">
        <location>
            <begin position="137"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005023397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="349" mass="40961" checksum="3400C1D094F7A65E" modified="2022-01-19" version="1">MAAARALVAALAVFLVVVSVQASKYSREANEGLPDAKRRETGEFRVVRLNQIWEKAQRLHLSAVKLAELHSDLKIQEKDELSWKKLKAEGLDEDGEKEAKLRRNLNVIMTKYGMNGKKDSHLTDTNYIKDGTESDTLDDPRLEKLWSKAKTSGKFSDEELDKLWREFKHHKEKIREYNILLETVSRTEDIHKNVINPSEENLVKEEVLHNKHRELKDKLRSINQGFERLRKVSHQGYDATSEFEEPRVIDLWDMAKSANFTEKELESFREELKHFEAKIEKHHHYQKQLEISHEKLKHIEGTGDKEHLNRNREKYAMLEEKTKELGYKVKKHLQDLSSRISQGLQHNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U6V4</accession>
    <name>A0A8C2U6V4_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Ankyrin repeat and LEM domain-containing protein 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">LEM domain-containing protein 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">ANKLE2</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit. Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly. May regulate nuclear localization of VRK1 in non-dividing cells. It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex. Involved in brain development.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Interacts with BAF/BANF1. Interacts with protein phosphatase 2A (PP2A) components PPP2C (PPP2CA or PPP2CB) and PPP2R1A.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type III membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ANKLE2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015733065.1">
        <property type="nucleotide sequence ID" value="XM_015877579.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U6V4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005033104.1">
        <property type="protein sequence ID" value="ENSCJPP00005024264.1"/>
        <property type="gene ID" value="ENSCJPG00005019164.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107321065"/>
    <dbReference type="CTD" id="23141"/>
    <dbReference type="GeneTree" id="ENSGT00390000016767"/>
    <dbReference type="OrthoDB" id="7446186at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004860">
        <property type="term" value="F:protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051721">
        <property type="term" value="F:protein phosphatase 2A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007417">
        <property type="term" value="P:central nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007084">
        <property type="term" value="P:mitotic nuclear membrane reassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd12944">
        <property type="entry name" value="LEM_ANKL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000072">
        <property type="entry name" value="Ankyrin repeat and LEM domain containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.720.40:FF:000001">
        <property type="entry name" value="LEM domain containing 2, isoform CRA_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056237">
        <property type="entry name" value="ANKLE2_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011015">
        <property type="entry name" value="LEM/LEM-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035006">
        <property type="entry name" value="LEM_ANKL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003887">
        <property type="entry name" value="LEM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12349">
        <property type="entry name" value="ANKYRIN REPEAT AND LEM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12349:SF4">
        <property type="entry name" value="ANKYRIN REPEAT AND LEM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24567">
        <property type="entry name" value="ANKLE2_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03020">
        <property type="entry name" value="LEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00540">
        <property type="entry name" value="LEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63451">
        <property type="entry name" value="LEM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50954">
        <property type="entry name" value="LEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="LEM" evidence="18">
        <location>
            <begin position="5"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="743"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="850"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="755"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="850"/>
            <end position="859"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00056222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00063367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00074558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00081980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005024264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="934" mass="104027" checksum="5AB38001C31962AB" modified="2022-01-19" version="1">MDAILSRLKQLSPDELREELVRAGLKCGPVTSTTRFIFEKKLAQFLLEQQGTLEGEGSAWSEEAAGSALSDGTHPALKTTAANHSHHVSEEVDFGYCVGLNPPEEEAVAHTNCSAPVSGAGYGGSQGSAQMPSRDPPLYYGVCPVYDDILARNERIHVYEDKKEALQAVKMIKGSRFKAFSNREDAEKFAKGICDYFPSPSKSSLCLSPMKTGPLNRDGLCSLEMETANKERANSYKSPRTQDLTAKLRKAVEKGDISTFSELIWSNPRYLIGSGDNPTVVQEGCRYNVMHVAAKENQPAICQLLLDTLENPEFMRLMYPDDDNTMLKNRIRYIVDLYLNTPDKMGFDTPLHFACKFGNLDVVNVLTSHPAIVKNPRNKYDQTPAEVVCERSKNKSAELKEKLREYLKGRYYVPLLRAEDNSSAPVIGAPWSPDQTDESPQAALSKYIGSPKDPVLSIRAFAGPMSPSKAEEFRRLWKTPPRERAGFFHNVRKSDLERGVERVGRELAHELGFPWVEYWEFLGCFVDLSSQEGLRKLEEYLSHWEMSEKAQQETGENETCNRYKTPHPSGKSKKCCNSISVGAFLDEDDDDMSLEEIKNRQNAARNNSPPVVLKEPSIDAIGDAECEILSRERTRNIIETSAQPRHYEKGVSSSRNGFCNPVATERIIGDRKHMHDGEDCLVSPVCNLMSEFESLTFQPQAGTGESNTISEKMKNERILPERTRQGRIPKDWLDKSCYAVSPVSSSESSVTGKPGETKLRTEHKVQSERERLSVESGIQTNEAQQFQEPPAQKFLLKTSPTNESSKKLFLLGEHPSKLDSDVLAAIEAVQIDPQKYPAIYRWKHEVQSYSSADRQSWPSPAQKGRFRSQSTAAGPPNASVYSSPGRNSPMPGSPGKHGSAASFSPDLGSPGRYSPASVNHSMLKLRYFSEPSAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U946</accession>
    <name>A0A8C2U946_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein 98</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">TMEM98</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Extracellular exosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TMEM98 family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSCJPT00005033048.1">
        <property type="protein sequence ID" value="ENSCJPP00005024217.1"/>
        <property type="gene ID" value="ENSCJPG00005019117.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000012062"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070062">
        <property type="term" value="C:extracellular exosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1410.10:FF:000003">
        <property type="entry name" value="Transmembrane protein 98"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1410.10">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029668">
        <property type="entry name" value="TMEM98"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32510">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 98"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32510:SF3">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 98"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005024217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="294" mass="32066" checksum="D84AAD5657BF3DDA" modified="2022-01-19" version="1">METVVIVAIGVLATIFLASFVALVVVCRQRYCRPKDLLHPYDTKPIVDLIGAMETQSEPSELELDDVVITNPHIEAILENEDWIQDASGLVSHCIAILKICHTLTEKLVAMTMGSGSRVKSPSSLSDVIVAAKRISPRVDDVVRSMYPPLDPKLLDARAAALLLSVTHLVLVTRSACPQPGDRDWVDRSLAAAEQHMEALRHAAMAAEPERNGTGTEPHRQEQSXXXXXXXXTPICGQSHAPSLTYTPKPRPSLTYVPIYGQADHAPSLTYTAIYGQARHSPSLTYTPQATPPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U984</accession>
    <name>A0A8C2U984_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cohesin subunit SA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">SCC3 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Stromal antigen</fullName>
        </alternativeName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Part of the cohesin complex which is composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the SCC3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2U984"/>
    <dbReference type="Ensembl" id="ENSCJPT00005031505.1">
        <property type="protein sequence ID" value="ENSCJPP00005022983.1"/>
        <property type="gene ID" value="ENSCJPG00005018265.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182972"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008278">
        <property type="term" value="C:cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039662">
        <property type="entry name" value="Cohesin_Scc3/SA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056396">
        <property type="entry name" value="HEAT_SCC3-SA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020839">
        <property type="entry name" value="SCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013721">
        <property type="entry name" value="STAG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11199:SF2">
        <property type="entry name" value="COHESIN SUBUNIT SA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11199">
        <property type="entry name" value="STROMAL ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24571">
        <property type="entry name" value="HEAT_SCC3-SA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21581">
        <property type="entry name" value="SCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08514">
        <property type="entry name" value="STAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51425">
        <property type="entry name" value="SCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="2" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="921"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="domain" description="SCD" evidence="4">
        <location>
            <begin position="259"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU369063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005022983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="938" mass="107451" checksum="FD9A0128B8CE9AFC" modified="2022-01-19" version="1">QVGVQAGLEYLQRRRLHHLPGQPVPVLRHPHCKEVLVHVRAELPMLYFHPIIITFCCCSVVDDWVEAYKQDRNVALLDLINFFIQCSGCQGMVTAEMFQNSHKRDGNKIPSNRMDVMQKMTETFDEVDYPVIRTGPYWKKFKANFCEFIAVLVQQCQCSILYDSYLMDTIISLLTGLADSVIRAFRHTSTLAAMKLLTAVISVHLNLDVNKHNAQRLYEVEKNRISGKRTNYRLDQLERKKKELVEIQNMMHAIFKGTFLSRYRDIVPEIRATCIEEIGNWIKTYPDVFLNDGYLKYIGWMLYDKQAEVRLKCLLGLQGIYSRKDLVSKMDLFTCRFKDRIVSMPLDKDHEVAVQAMKLLMLMSQNCEDVLSAEDCETLYQLVYTTHRPLAVAAGEFLYKRYLCLPAYFLLICFFLESELHKHVAYLIDSLWDWAGKFLKDWECMTTLLLKNDEGDGKVLNDAQESALIEIILATVREAAEGHPPVGRGAAKKILSVKEKKIQSEDCTKITEHFIMVLPQLLAKYSTDAQKVANLLHIPQYYDLDVYSTGHLEKHLDALLSEIKDIVAKHSDLSVLEASSRTYYILCSEKIAIYSKVDCARTQLIDELMGQLNQLLDGFWQKVSVTHCGDKQTVSIFDLLCLLDVQIAAAMKSNTVSKSFIGFVCFIQAFVILCDWLLILSHQDSNNNEEAIGLLDYLPSTSLQEKLLFFIQEHVFVEEEEGKEGRKDESCKLDNLHKKRSLLAAYCKLIVYNVVEMAAAAEIYKHYVKTYSDFGDIIKETLSRTRHRLHVVADLGLLLQLFQTYAESQDSSTGVDLSSASFINMKELARRFSLTFGWDQLRSRESVAMIHKEGIEFAFQGTTGTDGKCLPPNLGFLLIISEFSNKLLKPDKRVVCSEGGGWGLFLLLCCSLGLYAALIHQLYYFFIYILYIFWIVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UAN9</accession>
    <name>A0A8C2UAN9_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Probable ATP-dependent RNA helicase DHX34</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC107325041</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015741009.2">
        <property type="nucleotide sequence ID" value="XM_015885523.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UAN9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005033044.1">
        <property type="protein sequence ID" value="ENSCJPP00005024214.1"/>
        <property type="gene ID" value="ENSCJPG00005019114.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107325041"/>
    <dbReference type="KEGG" id="cjo:107325041"/>
    <dbReference type="GeneTree" id="ENSGT00940000158721"/>
    <dbReference type="OrthoDB" id="9111495at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF221">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="76"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005024214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="322" mass="36704" checksum="83C02BCE244F3085" modified="2022-01-19" version="1">MAIVEPETLQGDPIHGDPIQSTNRAQSQPQTPYSDQSIPYGDQSKPHKTQALYDDQSRPYNPQTPYSDQSKPHRPQTLQDDPIQTQYGDISRPYKPQTPYRDPYIPHNLYDDLYIPYKHHIELHSALLHYITFTQQRSFNKLTQIHRDRSNLPIAPYRAAILDALDQNRVVLVSGDPGCGKSTQVPQFLLEGGYKHVACTQPRRIACIALANRVAYESLQQYGQQVIYNPIPKEESEFTPTKWDRLDPRPYLRVLESIDRRFPQEECGDLLVFLSGVPEIGVVMEAVRGYVETSGRWVLLPLHSALPVAEQDKVIMGGYRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UAP8</accession>
    <name>A0A8C2UAP8_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cyclic nucleotide gated channel subunit alpha 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">CNGA3</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015706503.1">
        <property type="nucleotide sequence ID" value="XM_015851017.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UAP8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005034112.1">
        <property type="protein sequence ID" value="ENSCJPP00005025048.1"/>
        <property type="gene ID" value="ENSCJPG00005019699.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107307507"/>
    <dbReference type="KEGG" id="cjo:107307507"/>
    <dbReference type="CTD" id="1261"/>
    <dbReference type="GeneTree" id="ENSGT00940000156074"/>
    <dbReference type="OrthoDB" id="421226at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017071">
        <property type="term" value="C:intracellular cyclic nucleotide activated cation channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030553">
        <property type="term" value="F:cGMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005222">
        <property type="term" value="F:intracellularly cAMP-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005223">
        <property type="term" value="F:intracellularly cGMP-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000002">
        <property type="entry name" value="Cyclic nucleotide gated channel alpha 1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.630:FF:000001">
        <property type="entry name" value="Cyclic nucleotide-gated channel alpha 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000030">
        <property type="entry name" value="Cyclic nucleotide-gated channel alpha 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.630">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032406">
        <property type="entry name" value="CLZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050866">
        <property type="entry name" value="CNG_cation_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638:SF6">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED CATION CHANNEL ALPHA-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16526">
        <property type="entry name" value="CLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="344"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="416"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="14">
        <location>
            <begin position="520"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="146"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="712"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="661"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="149"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="721"/>
            <end position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005025048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="731" mass="84689" checksum="B496171FEAE2625E" modified="2022-01-19" version="1">MAKINTQHSYPGMHGLSVRTTDEDIERIENGFIRPIRLCEDTSSELQRVISMEGRHLSGSQTSPFTGRGAMARLSRFVVSLRSWATRHLHHEDQRPDSFLERIRGPEFVEVSSRQSNIRSFLGIREQPGGVNSPWPLARFNVNFSNNTNEDKKEEKKEVKEEKKEEKKEEKKEEKKDDKKDDKKDDKKKEEQKKEVFVIDPSSNMYYNWLTIIAAPVFYNWCMLICRACFDELQIDHIKLWLFLDYCSDIIYVFDMFVRFRTGFLEQGLLVKDEKKLRDHYTQTTQFKLDVLSLLPTDLAYLKLGLNYPELRFNRLLRIARLFEFFDRTETRTNYPNMFRIGNLVLYILIIIHWNACIYFAISKVIGFGTDSWVYPNVSNPEYGRLSRKYIYSLYWSTLTLTTIGETPPPVKDEEYFFVVVDFLVGVLIFATIVGNVGSMISNMNATRAEFQAKVDAIKQYMQFRKVTKDMETKVIKWFDYLWTNKKAVDEREVLKSLPDKLRAEIAINVHLETLKKVRIFQDCEAGLLIELVLKLKPTVFSPGDYVCRKGDIGREMYIIKEGKLAVVADDGMTQFVVLSDGSYFGEISILNIKGSKAGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPEAKKALEEKGRQILMKDNLIDEEAAKAGADPKDLEEKIDRLETALDTLQTRFARLLAEYSSSQQKVKQRLARVETRVKKYGSGTLSVGEAESEKPEEQKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UAR6</accession>
    <name>A0A8C2UAR6_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Sodium/potassium/calcium exchanger 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">Na(+)/K(+)/Ca(2+)-exchange protein 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="24">Solute carrier family 24 member 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="29" type="primary">SLC24A5</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="29" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="29" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="21">Calcium, potassium:sodium antiporter that transports 1 Ca(2+) and 1 K(+) to the melanosome in exchange for 4 cytoplasmic Na(+). Involved in pigmentation, possibly by participating in ion transport in melanosomes. Predominant sodium-calcium exchanger in melanocytes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>Ca(2+)(out) + K(+)(out) + 4 Na(+)(in) = Ca(2+)(in) + K(+)(in) + 4 Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:69967"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Melanosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2UAR6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005034029.1">
        <property type="protein sequence ID" value="ENSCJPP00005024993.1"/>
        <property type="gene ID" value="ENSCJPG00005019658.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234532"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042470">
        <property type="term" value="C:melanosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008273">
        <property type="term" value="F:calcium, potassium:sodium antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070509">
        <property type="term" value="P:calcium ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042438">
        <property type="term" value="P:melanin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030318">
        <property type="term" value="P:melanocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048022">
        <property type="term" value="P:negative regulation of melanin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000009">
        <property type="entry name" value="sodium/potassium/calcium exchanger 5 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000015">
        <property type="entry name" value="sodium/potassium/calcium exchanger 5 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004481">
        <property type="entry name" value="K/Na/Ca-exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00367">
        <property type="entry name" value="calcium/sodium antiporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846">
        <property type="entry name" value="SODIUM/POTASSIUM/CALCIUM EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846:SF61">
        <property type="entry name" value="SODIUM_POTASSIUM_CALCIUM EXCHANGER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0050">Antiport</keyword>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="15" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="18 26" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="10 27" id="KW-0732">Signal</keyword>
    <keyword evidence="16" id="KW-0915">Sodium</keyword>
    <keyword evidence="19" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="12" id="KW-0769">Symport</keyword>
    <keyword evidence="9 26" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 26" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="27">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034861919" description="Sodium/potassium/calcium exchanger 5" evidence="27">
        <location>
            <begin position="33"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="332"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="395"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="459"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="28">
        <location>
            <begin position="72"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="28">
        <location>
            <begin position="333"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="32"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00033627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00058187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00069887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00081356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00082809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005024993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="492" mass="54240" checksum="90AC991CED5393B2" modified="2022-01-19" version="1">ALRAVEMQWRRRAALLLLLLALRGWEPRGARAQRPAADTDNSTDCVPPSSEFPEGFFTPQERKDGGIVIYFLIILYMFLAASIVCDDYFLPSLEIITECLGLSQDVAGATFMAAGSSAPELVTAFLGVFVTKGDIGVSTILGSAIYNLLGICAACGLLSSVVSRLSCWPLFRDCLAYTISAAAVLAMISDSRIYWYESASLLLIYGCYILVLCFDIKINRCLMRKLSPCCWCFTKAAEQSGEQQPLAGWREESGPLIRQQSRTDSGIFQDELDYSQLSTSLHGLDEISEDHPSVFTMPEEDMKRILWVLSLPITTLLYLTIPDCRRRFWRNWFMVTFFMSAAWISAITYVLVWMITIAGETLGIPESVMGLTLLAAVASVLVARKGNGDMAMSNIVGSNVFDMLCLGIPWFIKTAFINTSGPIEVNSGGLTYTATSLICSVVFIFLAIHLNGWKIDKKLGAICLILYLVFTVLSILYELGIIGNNPTRVCGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UAZ1</accession>
    <name>A0A8C2UAZ1_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Lysophosphatidic acid receptor 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LPAR6</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015707298.1">
        <property type="nucleotide sequence ID" value="XM_015851812.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UAZ1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005034266.1">
        <property type="protein sequence ID" value="ENSCJPP00005025168.1"/>
        <property type="gene ID" value="ENSCJPG00005019776.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107308153"/>
    <dbReference type="KEGG" id="cjo:107308153"/>
    <dbReference type="CTD" id="10161"/>
    <dbReference type="GeneTree" id="ENSGT01040000240444"/>
    <dbReference type="OrthoDB" id="5781782at2759"/>
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    <keyword evidence="4 10" id="KW-0297">G-protein coupled receptor</keyword>
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    <sequence length="363" mass="41912" checksum="8142EC89BD17A2FA" modified="2022-01-19" version="1">MITTAVGREERAPGDEPQHTQRFSEALRRSRSTSTAVLEACKSCPENTGESCASQQLRLGFLIDHYNVRNETTTYMLNLAISDLLFVFTLPFRIYYFVVRNWPFGDVLCKISVTLFYTNMYGSILFLTCISVDRFLAIVHPFRSKTLRTKRNARIVCVAVWITVLAGSTPASFFQSTNRQNNTEQRTCFENFPESTWKTYLSRIVIFIEIVGFFIPLILNVTCSTVVLRTLNKPLTLSRNKLSKKKVLKMVFVHLVIFCFCFVPYNITLILYSLMRTQTWVNCSVVTAVRTMYPVTLCIAVSNCCFDPIVYYFTSDTIQNSIKNNRFTRTRDNRFSETPLSDNFLQHSFQTIKMKIFDSDSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UCA6</accession>
    <name>A0A8C2UCA6_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Actin binding LIM protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ABLIM1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2UCA6"/>
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        <property type="protein sequence ID" value="ENSCJPP00005025621.1"/>
        <property type="gene ID" value="ENSCJPG00005020075.1"/>
    </dbReference>
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        <property type="component" value="Chromosome 6"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="C:postsynaptic density"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:cytoskeleton organization"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:lamellipodium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:transcription by RNA polymerase II"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="LIM1_abLIM"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="LIM2_abLIM"/>
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    <dbReference type="CDD" id="cd09329">
        <property type="entry name" value="LIM3_abLIM"/>
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        <property type="entry name" value="actin-binding LIM protein 1 isoform X1"/>
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    </dbReference>
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        <property type="entry name" value="actin-binding LIM protein 1 isoform X1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="actin-binding LIM protein 1 isoform X2"/>
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        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="Villin headpiece domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032402">
        <property type="entry name" value="AbLIM_anchor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051618">
        <property type="entry name" value="Actin-binding_LIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003128">
        <property type="entry name" value="Villin_headpiece"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036886">
        <property type="entry name" value="Villin_headpiece_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24213">
        <property type="entry name" value="ACTIN-BINDING LIM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24213:SF18">
        <property type="entry name" value="ACTIN-BINDING LIM PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16182">
        <property type="entry name" value="AbLIM_anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02209">
        <property type="entry name" value="VHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00153">
        <property type="entry name" value="VHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47050">
        <property type="entry name" value="VHP, Villin headpiece domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51089">
        <property type="entry name" value="HP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0440">LIM domain</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="10">
        <location>
            <begin position="49"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="10">
        <location>
            <begin position="109"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="10">
        <location>
            <begin position="176"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="HP" evidence="11">
        <location>
            <begin position="707"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="385"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="467"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="640"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="392"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="418"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
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    </evidence>
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        </source>
    </evidence>
    <sequence length="775" mass="86831" checksum="239E9B71D2556368" modified="2022-01-19" version="1">NKLLVKGVNISLIPCSVLTDSFCVGLNYILCLTVAHPQEPHHPSEKPVIHCHKCGEPCKGEVLRVQSRHFHIKCFTCKVCGCDLAQGGFFIKNGEYLCTLDYQRMYGTRCNGCGEFVEGEVVTALGKTYHPNCFACTVCKRPFPPGDRVTFNGRDCLCQLCAQPMSSSPKELSASSNCAGCGRDIKNGQALLALDKQWHLGCFKCKACGKVLTGEYISKDGAPYCEKDYQVLFGVKCEACHQFITGKVLEAGDKHYHPSCARCSRCNQMFTEGEEMYLPHWFIAILCNVCIEDCSLSSLQLLIALDSSEKLLFVFQPTRTSSESIYSRPGSSIPGSPGHTIYAKVDNEILDYKDLAAIPKVKAIYDIERPDLITYEPFYTSAYEDRQERQSLGESPRTLSPTPSAEGYQDVRDRMIHRSTSQGSINSPVYSRHSYTPTMSRSPQHFHRPELLSTGVQRFSYLRTSSLSSAHHDSRPNSPFRHHFIPHVKGNEPSSGRNSPVPYRPDSRPLTPTYAQAPKHFHVPDQGVNIYRKPPIYKQHAALAAQSKSSEDIIKSSKFPAAHAPAPNEIPKIETDHWPGPPSLAAIGADMRRRSSGREEDDEELLRRRQLQEEQLMKLNSGLGQLILKEEMEKERLALSASRYDSPAHASASKTSSLPGYGKNGLHRPVSTDFGQYNSYGDVSGGSLPDGHVPGMRMDRGVSMPNMLEPKIFPYEILMVTNRGRNKILKDVDRTRLERHLAPEVFQEIFGMTIQEFDKLPLWRRNDMKKKAKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UCS4</accession>
    <name>A0A8C2UCS4_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Proline and serine rich 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">PROSER1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015707390.1">
        <property type="nucleotide sequence ID" value="XM_015851904.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UCS4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005034436.1">
        <property type="protein sequence ID" value="ENSCJPP00005025303.1"/>
        <property type="gene ID" value="ENSCJPG00005019876.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107308203"/>
    <dbReference type="KEGG" id="cjo:107308203"/>
    <dbReference type="CTD" id="80209"/>
    <dbReference type="GeneTree" id="ENSGT00730000111188"/>
    <dbReference type="OrthoDB" id="5968166at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028011">
        <property type="entry name" value="DUF4476"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042616">
        <property type="entry name" value="PROSER1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14880">
        <property type="entry name" value="PROLINE AND SERINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14880:SF2">
        <property type="entry name" value="PROLINE AND SERINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14771">
        <property type="entry name" value="DUF4476"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4476" evidence="2">
        <location>
            <begin position="31"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="500"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="913"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="506"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="539"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="554"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="918"/>
            <end position="938"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005025303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="938" mass="95150" checksum="6ACF8181919781FF" modified="2022-01-19" version="1">MDKKSFETVLDEIRKAVLTEYKLKAIEYVHGYFSSEQVVELLRYFSWAEPQLKAIKALQHKIVAVPASKMVNILNCFTFSKDKLIALEILASNIVDAQNYRLIEDLFRINMSEKKRCRRILEQASKTGCKAPHAMISSCGMIPGNPYPKGKPSRINGIFPGTPIKKDTEECTSEGKGIAARILGPSKPAPSTYNPHKPVPYPIPPCRPHATIAPSAYNNAGLVPMANVIAPGLPAPSTYTANQGVSENEDLSNQAKPSQNQAFSAQTNQLFTPHGSNPSTPAATPVPTPSPVKAISHPLAPATPLISGMNMSTPVLPVFPGQVSSSTHTSQPSTPTPTVIKSLSLPGVPVTSVHSATSTPIPAVFSGLASIPSAMPAPQGSSTPCATPAPSEAFASATTPFAGLPFSAASSVASASNPTPLSSVFAGLPLSLPPSVQGISSPVPSTIANSPATTIPGSLSLPNPILSVLKGFLTSNDTSLINSSALPSAMTSELASLSALANQSSDPPTSSVKCYTPSATPTSQRSSTPGLAIFPGLPSPSVTNSSSTPPTLPAQSPLTTSPSVMPVNCGSSASLLHGTSPTNPDQQLSSTPVATSIPQVLIKTEPMSPTLSAFKGPSHSAGPSHGTVGLSALGRAYTSATSVPVSLPSSLNPALSSLSSLSAPLNNPSSLASISLAPHGSTAPIAPVFNGLPPFTSLTSNFAFTGNPALTPPVTLPGSLLATPATTASAVSAPHVNSTAAVLSGLAASATVSAPPFSLNLSSAVPSLFSVAQGPLGSSNPSFPGFPVSNTPSVTPALPSFPGLQASSAVAAVAPLPAAATAPSPAPVLPGFASAFSSNFNSALVAQAGLTSGLQTPGNAVFPGLLSLPGIPGFPQSAAQSSLQELQHSAAAQSALLQAHSASALENYTAQPEGFANYPSTPGTPFSLQTSLPQSGWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UE25</accession>
    <name>A0A8C2UE25_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Myocyte enhancer factor 2A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">MEF2A</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2UE25"/>
    <dbReference type="Ensembl" id="ENSCJPT00005035978.1">
        <property type="protein sequence ID" value="ENSCJPP00005026538.1"/>
        <property type="gene ID" value="ENSCJPG00005020647.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156205"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035035">
        <property type="term" value="F:histone acetyltransferase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042826">
        <property type="term" value="F:histone deacetylase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061629">
        <property type="term" value="F:RNA polymerase II-specific DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046332">
        <property type="term" value="F:SMAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061337">
        <property type="term" value="P:cardiac conduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071277">
        <property type="term" value="P:cellular response to calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070375">
        <property type="term" value="P:ERK5 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048311">
        <property type="term" value="P:mitochondrion distribution"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010613">
        <property type="term" value="P:positive regulation of cardiac muscle hypertrophy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046326">
        <property type="term" value="P:positive regulation of D-glucose import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055005">
        <property type="term" value="P:ventricular cardiac myofibril assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00265">
        <property type="entry name" value="MADS_MEF2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1810.10:FF:000001">
        <property type="entry name" value="Myocyte-specific enhancer factor 2A homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022102">
        <property type="entry name" value="HJURP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033896">
        <property type="entry name" value="MEF2-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11945">
        <property type="entry name" value="MADS BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11945:SF637">
        <property type="entry name" value="MYOCYTE-SPECIFIC ENHANCER FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12347">
        <property type="entry name" value="HJURP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00404">
        <property type="entry name" value="MADSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00432">
        <property type="entry name" value="MADS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00350">
        <property type="entry name" value="MADS_BOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="10">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="218"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="426"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="426"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="466"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="482"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="504"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="525"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005026538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="546" mass="59241" checksum="9E5EE5DF5FF0E322" modified="2022-01-19" version="1">MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSSNKLFQYASTDMDKVLLKYTEYNEPHESRTNSDIVETLRKKGLNGCESPDADDYFEHSPLSEDRFSKLNEDSDFIFKRGPALNKKEHRGCDSPDPDTSYVLTPHTEEKYKKINEEFDNMMRNHKIAPGLPAQNFSMSVTVPVSNPNTLTYSNPGSSLVSPSLAASSSLTDTTMLSPPQTTLHRNVSPGAPQRPPSTGNAGGMLGTTDLSVPNGAGTSPVGNGFVNSRASPSLLGTAGGGNGLGKVMPTKSPPPPGGGNLGMNNRKPDLRVVIPPSSKGMMPPLTEEDELELNTQRISSSQSTQPLATPVVSVTTPSLPPQGLVYSAMPTAYNTDYSLTSADLSALQGFNSPGMLSLGQVSAWQQHHLGPATLSSLVSGSQLSQGSNLSINTNQNINIKSEPISPPRDRVTPSGFPQQPPQQPQPPQPPQQPPQRQELGRSPVDSLSSSSSSYDGSDREDPRSDFHSPVVLGRPPNSEDRESPSVKRMRMDTFCFQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UGI7</accession>
    <name>A0A8C2UGI7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucosamine-6-phosphate isomerase</fullName>
            <ecNumber evidence="9">3.5.99.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glucosamine-6-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">GNPDA1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the reversible conversion of alpha-D-glucosamine 6-phosphate (GlcN-6P) into beta-D-fructose 6-phosphate (Fru-6P) and ammonium ion, a regulatory reaction step in de novo uridine diphosphate-N-acetyl-alpha-D-glucosamine (UDP-GlcNAc) biosynthesis via hexosamine pathway. Deamination is coupled to aldo-keto isomerization mediating the metabolic flux from UDP-GlcNAc toward Fru-6P. At high ammonium level can drive amination and isomerization of Fru-6P toward hexosamines and UDP-GlcNAc synthesis. Has a role in fine tuning the metabolic fluctuations of cytosolic UDP-GlcNAc and their effects on hyaluronan synthesis that occur during tissue remodeling. Seems to trigger calcium oscillations in mammalian eggs. These oscillations serve as the essential trigger for egg activation and early development of the embryo.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>alpha-D-glucosamine 6-phosphate + H2O = beta-D-fructose 6-phosphate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12172"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:75989"/>
            <dbReference type="EC" id="3.5.99.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 9">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.99.6" evidence="9"/>
    <dbReference type="RefSeq" id="XP_015730976.1">
        <property type="nucleotide sequence ID" value="XM_015875490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UGI7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005036452.1">
        <property type="protein sequence ID" value="ENSCJPP00005026913.1"/>
        <property type="gene ID" value="ENSCJPG00005020901.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107320042"/>
    <dbReference type="KEGG" id="cjo:107320042"/>
    <dbReference type="CTD" id="10007"/>
    <dbReference type="GeneTree" id="ENSGT00390000014316"/>
    <dbReference type="OrthoDB" id="7663298at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004342">
        <property type="term" value="F:glucosamine-6-phosphate deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006091">
        <property type="term" value="P:generation of precursor metabolites and energy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006043">
        <property type="term" value="P:glucosamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006046">
        <property type="term" value="P:N-acetylglucosamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019262">
        <property type="term" value="P:N-acetylneuraminate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01399">
        <property type="entry name" value="GlcN6P_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1360:FF:000004">
        <property type="entry name" value="Glucosamine-6-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01241">
        <property type="entry name" value="GlcN6P_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004547">
        <property type="entry name" value="Glucosamine6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018321">
        <property type="entry name" value="Glucosamine6P_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00502">
        <property type="entry name" value="nagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11280">
        <property type="entry name" value="GLUCOSAMINE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11280:SF8">
        <property type="entry name" value="GLUCOSAMINE-6-PHOSPHATE ISOMERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01161">
        <property type="entry name" value="GLC_GALNAC_ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine/galactosamine-6-phosphate isomerase" evidence="10">
        <location>
            <begin position="12"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005026913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="288" mass="32319" checksum="6BFF660AF4583A20" modified="2022-01-19" version="1">MKLIIQETYAQASEWAAKYIRNRIVHFAPGPGRFFTLGLPTGSTPLGCYRKLVEYYRNGDLSFKYVKTFNMDEYVGLPRDHPESYHSFMWNNFFKHVDISAENVHILDGNAADLQAECDAFEDKIKAAGGIELFVGGIGPDGHIAFNEPGSSLVSRTRVKTLAMDTILANARFFDGDLSKVPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHPKTVFVCDEDATLELRVKTVKYFKGLMLVHNKLVEPLYSMKETEAERSQSKKPYSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UH26</accession>
    <name>A0A8C2UH26_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Antithrombin-III</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Serpin C1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">SERPINC1</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Forms protease inhibiting heterodimer with TMPRSS7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the serpin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015725185.1">
        <property type="nucleotide sequence ID" value="XM_015869699.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UH26"/>
    <dbReference type="Ensembl" id="ENSCJPT00005037185.1">
        <property type="protein sequence ID" value="ENSCJPP00005027515.1"/>
        <property type="gene ID" value="ENSCJPG00005021333.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107317248"/>
    <dbReference type="KEGG" id="cjo:107317248"/>
    <dbReference type="CTD" id="462"/>
    <dbReference type="GeneTree" id="ENSGT00940000157967"/>
    <dbReference type="OrthoDB" id="9440847at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002020">
        <property type="term" value="F:protease binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007596">
        <property type="term" value="P:blood coagulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030193">
        <property type="term" value="P:regulation of blood coagulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02045">
        <property type="entry name" value="serpinC1_AT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.497.10:FF:000008">
        <property type="entry name" value="antithrombin-III isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033829">
        <property type="entry name" value="Antithrombin_3_serpin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023795">
        <property type="entry name" value="Serpin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461:SF53">
        <property type="entry name" value="ANTITHROMBIN-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00093">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00284">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0094">Blood coagulation</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0356">Hemostasis</keyword>
    <keyword evidence="7" id="KW-0358">Heparin-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="11" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="10 18" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034125502" description="Antithrombin-III" evidence="18">
        <location>
            <begin position="16"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Serpin" evidence="19">
        <location>
            <begin position="81"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
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            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023084"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00033153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005027515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="452" mass="51425" checksum="F0A9862A6AA79BA9" modified="2022-01-19" version="1">MQLFLVCLFALWGMAAPVRYAVEDICTAKPRDIPVNPICIYRNPEKKAQESEVLEPGKGRIPGSTNPRVWELSRANSRFAVVFYKHLADSKDNEENIFLSPLSISTAFAMTKLGACGDTLQQLMEVFQFDTISEKTSDQVHFFFAKLNCRLYKKANKSSELISANRLFGEKSLVFNETYQNISEIVYGAKLWPLNFKEKPELSRQIINEWVANKTERRITEVIPERGIDDLTVLVLVNTIYFKGHWKSQFPALNTRLDLFHKANGETCKVPIMYQEARFRHAFIQDKVQVLELPYKGDDITMVLVLPRAGTPLVEVERDLTSDKLQDWIDSLVEVSLTVSLPRFRIEDSFSVKEKLRKMGLEDLFSPENAKLPGIVAEGRTDLYVSEAFHKAFLEVNEEGSEASAATAVVISGRSFPMNRITFEANRPFLLFIREAALNTIIFMGRISNPCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UH32</accession>
    <name>A0A8C2UH32_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Tripartite motif containing 65</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">TRIM65</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UH32"/>
    <dbReference type="Ensembl" id="ENSCJPT00005036283.1">
        <property type="protein sequence ID" value="ENSCJPP00005026784.1"/>
        <property type="gene ID" value="ENSCJPG00005020812.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161851"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140374">
        <property type="term" value="P:antiviral innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050728">
        <property type="term" value="P:negative regulation of inflammatory response"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900226">
        <property type="term" value="P:negative regulation of NLRP3 inflammasome complex assembly"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044546">
        <property type="term" value="P:NLRP3 inflammasome complex assembly"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032727">
        <property type="term" value="P:positive regulation of interferon-alpha production"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032728">
        <property type="term" value="P:positive regulation of interferon-beta production"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of NLRP3 inflammasome complex assembly"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032461">
        <property type="term" value="P:positive regulation of protein oligomerization"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070936">
        <property type="term" value="P:protein K48-linked ubiquitination"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070534">
        <property type="term" value="P:protein K63-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060337">
        <property type="term" value="P:type I interferon-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003879">
        <property type="entry name" value="Butyrophylin_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051051">
        <property type="entry name" value="E3_ubiq-ligase_TRIM/RNF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058030">
        <property type="entry name" value="TRIM8/14/16/25/29/45/65_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25465">
        <property type="entry name" value="B-BOX DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25465:SF14">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25600">
        <property type="entry name" value="TRIM_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01407">
        <property type="entry name" value="BUTYPHLNCDUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0391">Immunity</keyword>
    <keyword evidence="1" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="10"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="9">
        <location>
            <begin position="314"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="137"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
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            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005026784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="516" mass="58464" checksum="8F9775012A0CE0C5" modified="2022-01-19" version="1">MLSLEDKLLCSICLELFVVPITLPCGHNFCEHCIDNHRNKQEQAVNGPKRGYTCPTCRYSCEQHLELKKNVTLSDVVELARTGRVQAGGCEVAHVGLCSLHGRPLELYCEDEQRCICCVCVVRRCQQHRTALFEDVRSRKQAQLERSLEEAQREAERMEQALRELEERAQSIEVRPQPPQAVILSKFTHLEEALAKFREQMVAKVKQEESVAMGHIEKDRNALKDHLEALGQHRDQAQHLMDCTDHQTFLKEFLQLPTLQSMEVPPLVEFNVAVVMEPMSEILTATSRLLLEELPASLSPSAPEAPDPIAPGELQAALNASTSLWPLRLYHRNLTFDPDTANKYLELSCAQRRAKHGPSTAAGWQERSHRFEPWQVLCVQSYGQGRHYWEVTISSHSVVLGVTYGGLSRHKVKGCKFNIGLDGGSWGLQVREDSYVARHKGQEEKIQLRPYTELGVCLDYECGLLSFYGLGEEVQLIHSFHTVFTEPLFPVFWLCEGRTITLCHRDCEGNDGELGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UJ84</accession>
    <name>A0A8C2UJ84_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Pyrroline-5-carboxylate reductase</fullName>
            <ecNumber evidence="4 15">1.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">PYCR1</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-proline + NAD(+) = (S)-1-pyrroline-5-carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14105"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="13">
            <dbReference type="Rhea" id="RHEA:14107"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-proline + NADP(+) = (S)-1-pyrroline-5-carboxylate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:14111"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 15">Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.2" evidence="4 15"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2UJ84"/>
    <dbReference type="Ensembl" id="ENSCJPT00005036825.1">
        <property type="protein sequence ID" value="ENSCJPP00005027202.1"/>
        <property type="gene ID" value="ENSCJPG00005021103.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183044"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000064">
        <property type="entry name" value="Pyrroline-5-carboxylate reductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3730.10:FF:000003">
        <property type="entry name" value="Pyrroline-5-carboxylate reductase 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.10">
        <property type="entry name" value="ProC C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053790">
        <property type="entry name" value="P5CR-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00112">
        <property type="entry name" value="proC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645:SF62">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00521">
        <property type="entry name" value="P5CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6 15" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 14 15" id="KW-0521">NADP</keyword>
    <keyword evidence="10 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7 15" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034007027" description="Pyrroline-5-carboxylate reductase" evidence="16">
        <location>
            <begin position="27"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase catalytic N-terminal" evidence="17">
        <location>
            <begin position="3"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase dimerisation" evidence="18">
        <location>
            <begin position="164"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="6"/>
            <end position="11"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="69"/>
            <end position="72"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="95"/>
            <end position="97"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000193-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005027202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="318" mass="33434" checksum="75C85E134CD4D4DB" modified="2022-01-19" version="1">MSVGFIGAGQLAFALARGFTAAGVLAAHKITASSPDTELPTVTGLRKMGVNFTVSNKDTVKSSDVLFLAVKPPIIPFILDEVGPDIEERHIVVSCAAGVTISSIEKKLSAFCPTPKVIRCMTNTPVIVREGATVYATGTHADVEDGKLLEQLMASVGFCTEVEEDLIDAVTGLSGSGPAYAFTALDALADGGVKMGLPRRLAVRLGAQALLGAAKMLLESEQHPGQLKDNVCSPGGATIHALHFLESGGFRSLLINAVEASCIRTRWLQHLADKEKISPAAIKKTLLDKVKLESPSLSVASTNKVSLFNSKNPSSKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y4Y8</accession>
    <name>A0A8C2Y4Y8_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Complex I-18 kDa</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">NADH-ubiquinone oxidoreductase 18 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">NDUFS4</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFS4 subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015704211.1">
        <property type="nucleotide sequence ID" value="XM_015848725.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y4Y8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005001432.1">
        <property type="protein sequence ID" value="ENSCJPP00005000816.1"/>
        <property type="gene ID" value="ENSCJPG00005000889.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107305993"/>
    <dbReference type="KEGG" id="cjo:107305993"/>
    <dbReference type="CTD" id="4724"/>
    <dbReference type="GeneTree" id="ENSGT00390000013835"/>
    <dbReference type="OrthoDB" id="3089at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome Z"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.190:FF:000001">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 21 kDa subunit mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.190">
        <property type="entry name" value="atu1810 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006885">
        <property type="entry name" value="NADH_UbQ_FeS_4_mit-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038532">
        <property type="entry name" value="NDUFS4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12219:SF8">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12219">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04800">
        <property type="entry name" value="NDUS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="57"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="109"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="112"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005000816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="338" mass="36801" checksum="C391FC5BCCA286CB" modified="2022-01-19" version="1">MTQTSANITRATSGANSRPCTGRGPRPLWRNGGSRPLRLPAFMGNAPLGLRRRWARHDAVTSEQQPRGPAPSAPGARQAQQGRSDRPTLSGRSTLAADADRTAISRLLLASPSRQLAAPQSGTGRRTQPSRTHPAPSSSPARLRVSCLGGGGLAQRRRRPPAAEASVMAAALSMSTALRHLVAGSGAAVLRLSPARSLSTSTWRLAQDQTRDTQLITVDEKLDISTLTGVPDEHIKTRRVHIFVPARNAMQAGVNNTKKWKMEFDNRERWENPLMGWASTADPLSNMVLTFSTKEDAIAFAEKNGWSYDVEEKKIPKPKSKSYGANFSWNKRTRVSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y557</accession>
    <name>A0A8C2Y557_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Neutral amino acid transporter 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Solute carrier family 38 member 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">SLC38A9</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-asparagine(out) = L-asparagine(in)</text>
            <dbReference type="Rhea" id="RHEA:73423"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-glutamine(out) = L-glutamine(in)</text>
            <dbReference type="Rhea" id="RHEA:73419"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-leucine(in) = L-leucine(out)</text>
            <dbReference type="Rhea" id="RHEA:73011"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-tyrosine(in) = L-tyrosine(out)</text>
            <dbReference type="Rhea" id="RHEA:68572"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lysosome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the amino acid/polyamine transporter 2 family. SLC38A9 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015704213.1">
        <property type="nucleotide sequence ID" value="XM_015848727.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y557"/>
    <dbReference type="Ensembl" id="ENSCJPT00005002154.1">
        <property type="protein sequence ID" value="ENSCJPP00005001260.1"/>
        <property type="gene ID" value="ENSCJPG00005001322.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107305996"/>
    <dbReference type="KEGG" id="cjo:107305996"/>
    <dbReference type="CTD" id="153129"/>
    <dbReference type="GeneTree" id="ENSGT00390000005646"/>
    <dbReference type="OrthoDB" id="294730at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome Z"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990877">
        <property type="term" value="C:FNIP-folliculin RagC/D GAP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071986">
        <property type="term" value="C:Ragulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015485">
        <property type="term" value="F:cholesterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061459">
        <property type="term" value="F:L-arginine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015182">
        <property type="term" value="F:L-asparagine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015186">
        <property type="term" value="F:L-glutamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015190">
        <property type="term" value="F:L-leucine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032935">
        <property type="term" value="F:sterol sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071230">
        <property type="term" value="P:cellular response to amino acid stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF244">
        <property type="entry name" value="NEUTRAL AMINO ACID TRANSPORTER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0458">Lysosome</keyword>
    <keyword evidence="10 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="452"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="485"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="516"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="551"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="22">
        <location>
            <begin position="128"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="22">
        <location>
            <begin position="303"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00036663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00036878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00036887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00036984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00038442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00040233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00042870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005001260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="572" mass="63737" checksum="EBC9F9B42869CE58" modified="2022-01-19" version="1">MQKVHIEKTLVGVAAFFCSGRDHTCSICITGEEGKGGHLPAVFLFLRGPFHVEPTNIVSANDDMQRVSDEASAMNKRIHYYSRLTSPSDKALIAPDHVLPAPDEIYVYSPLGTAFKVDSCTDGHGKNSSIVTIFMIWNTMMGTSILSIPWGIKQAGFTSGIILIILMGILTLYCCYRVVKSRKMIPLTDTSNWEFPDVCKYYFGSFGQWSSLLFSMVSLVGAMVVYWVLMSNFLFNTGKFIYNFVHDINVTDIVPGTNGSNKVICPNAATGHPPQNQSVMFSSGNSTGFQLFEEWWSKSQTVPFYLVAVLLPLLNLKSPSFFAKFNVLGSVSVIYLVLLVTVKAAHLGIHLEFNWFTENEFFVPEFRVLFPQLTGVLTLAFFIHNCVITLLQNNKNQENNVRDLSIAYFLVGLTYLYVGVIIFASFPSPPLSKECIEQNFLDNFPSNDIMSFIARIFLLFQMITVYPLLGYLARVQLLRQVFGNAYPSVFHVLALNVAIVGAGVAMARFYPNIGGIIRYSGATCGLAFVFVYPSLIYVISLHRAGQLTWPALIIHIFIILLGLANLIAQFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y584</accession>
    <name>A0A8C2Y584_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y584"/>
    <dbReference type="Ensembl" id="ENSCJPT00005001479.1">
        <property type="protein sequence ID" value="ENSCJPP00005000841.1"/>
        <property type="gene ID" value="ENSCJPG00005000918.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000287554"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome LGE22C19W28_E50C23"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="297"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005000841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="351" mass="38148" checksum="1F096C5CCAF149B6" modified="2022-01-19" version="1">MVPWGGGGSAHPGAPHPPLGGGFGGVPLTNTSSISSNNRHPQPHTVVWAAPMLYPILPYPTAPYPIVPYPIKPYPIVPYPIVLYPPAPHPIVPYPTAPYPIVLYPIVLYPTVPYLPAPHPITPYPIVPYPIMPYPIVPYPTSPYPIVPYAPEPPPITPYPTAPYPIEPYPTAPFPIVAQALSICPAPTGCGSAVCSCNHWAWIQSVCSCINWVWVLSVCLVLYHWTWVCLSVCPVPLDMGLSVCPVSLGMDQSVCPVSLGMGLSVCLSCITGHGYVCLSVLYLWIWVCLSVLYRWAWVCLSVCPVSLGMGLSVCLSCITGYGSVCLSVLYHWVWVCLSVLHLWIWVCLSVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y703</accession>
    <name>A0A8C2Y703_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Homologous-pairing protein 2 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">PSMC3-interacting protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Proteasome 26S ATPase subunit 3-interacting protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">PSMC3IP</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HOP2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y703"/>
    <dbReference type="Ensembl" id="ENSCJPT00005008351.1">
        <property type="protein sequence ID" value="ENSCJPP00005005096.1"/>
        <property type="gene ID" value="ENSCJPG00005004930.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000006890"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120231">
        <property type="term" value="C:DNA recombinase auxiliary factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120230">
        <property type="term" value="F:recombinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007129">
        <property type="term" value="P:homologous chromosome pairing at meiosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000709">
        <property type="term" value="P:meiotic joint molecule formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010774">
        <property type="term" value="P:meiotic strand invasion involved in reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000394">
        <property type="entry name" value="Homologous-pairing protein 2 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010776">
        <property type="entry name" value="Hop2_WH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040661">
        <property type="entry name" value="LZ3wCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15938:SF0">
        <property type="entry name" value="HOMOLOGOUS-PAIRING PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15938">
        <property type="entry name" value="TBP-1 INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18517">
        <property type="entry name" value="LZ3wCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07106">
        <property type="entry name" value="WHD_TBPIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7" id="KW-0469">Meiosis</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homologous-pairing protein 2 winged helix" evidence="11">
        <location>
            <begin position="14"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine zipper with capping helix" evidence="12">
        <location>
            <begin position="154"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="86"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00077080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00078996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF18517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005005096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="218" mass="24944" checksum="4C1153D5551C45E7" modified="2022-01-19" version="1">MSKGREGPEGRPGAVVLRYLREQNRPYSAQDVHGNLQRETGMGKAAVLKALEQLAQQGRVREKPYGKHKIYFADQEQLPAAGDAELRALDADITARSRELQELLNNCRQLEAELKELNGTMTTTDMAREVEELRKDCSSYTEKLERIKSATNHVTPEEKEKVCSEHKLYCKEWRRRKRMATELLDAILEGYPKSKKQFFEEVGIETDEEHNVTLPAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y7G8</accession>
    <name>A0A8C2Y7G8_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the APC15 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y7G8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005009084.1">
        <property type="protein sequence ID" value="ENSCJPP00005005626.1"/>
        <property type="gene ID" value="ENSCJPG00005005353.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090266">
        <property type="term" value="P:regulation of mitotic cell cycle spindle assembly checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026182">
        <property type="entry name" value="ANAPC15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22526">
        <property type="entry name" value="ANAPHASE PROMOTING COMPLEX C SUBUNIT 15, PSEUDOGENE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22526:SF2">
        <property type="entry name" value="ANAPHASE PROMOTING COMPLEX C SUBUNIT 15, PSEUDOGENE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15243">
        <property type="entry name" value="ANAPC15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005005626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="118" mass="13099" checksum="7DDB7FCA74982AD4" modified="2022-01-19" version="1">MFTLFPSLLPRLTEPLWFNLDRPSVDETELQQQEQQHQAWKDNNLVRCWKRFRGGHTWDVGPPRASPWGAGDGRRINVAYGYKFWGGGGGGGGCQADGGRVGMGAFWGPPHPIPPLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y7M8</accession>
    <name>A0A8C2Y7M8_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Mab-21 like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MAB21L2</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the mab-21 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015716602.1">
        <property type="nucleotide sequence ID" value="XM_015861116.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y7M8"/>
    <dbReference type="SMR" id="A0A8C2Y7M8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005009558.1">
        <property type="protein sequence ID" value="ENSCJPP00005006011.1"/>
        <property type="gene ID" value="ENSCJPG00005005667.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107313147"/>
    <dbReference type="KEGG" id="cjo:107313147"/>
    <dbReference type="CTD" id="10586"/>
    <dbReference type="GeneTree" id="ENSGT01050000244827"/>
    <dbReference type="OrthoDB" id="5961151at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043010">
        <property type="term" value="P:camera-type eye development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008283">
        <property type="term" value="P:cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010172">
        <property type="term" value="P:embryonic body morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1410.40:FF:000002">
        <property type="entry name" value="protein mab-21-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.90:FF:000001">
        <property type="entry name" value="protein mab-21-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046903">
        <property type="entry name" value="Mab-21-like_nuc_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046906">
        <property type="entry name" value="Mab-21_HhH/H2TH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024810">
        <property type="entry name" value="MAB21L/cGLR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10656">
        <property type="entry name" value="CELL FATE DETERMINING PROTEIN MAB21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10656:SF37">
        <property type="entry name" value="PROTEIN MAB-21-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03281">
        <property type="entry name" value="Mab-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20266">
        <property type="entry name" value="Mab-21_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01265">
        <property type="entry name" value="Mab-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mab-21-like nucleotidyltransferase" evidence="7">
        <location>
            <begin position="62"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Mab-21-like HhH/H2TH-like" evidence="8">
        <location>
            <begin position="246"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="359" mass="40907" checksum="24B7A0CF0E78A1AA" modified="2022-01-19" version="1">MIAAQAKLVYQLNKYYTERCQARKAAIAKTIREVCKVVSDVLKEVEVQEPRFISSLSEIDARYEGLEVISPTEFEVVLYLNQMGVFNFVDDGSLPGCAVLKLSDGRKRSMSLWVEFITASGYLSARKIRSRFQTLVAQAVDKCSYRDVVKMIADTSEVKLRIRERYVVQITPAFKCTGIWPRSAAQWPMPHIPWPGPNRVAEVKAEGFNLLSKECYSLTGKQSSAESDAWVLQFGEAENRLLMGGCRNKCLSVLKTLRDRHLELPGQPLNNYHMKTLLLYECEKHPRETDWDEACLGDRLNGILLQLISCLQCRRCPHYFLPNLDLFQGKPHSALESAAKQTWRLAREILTNPKSLDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y9F4</accession>
    <name>A0A8C2Y9F4_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MYB binding protein 1a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">MYBBP1A</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="Ensembl" id="ENSCJPT00005015103.1">
        <property type="protein sequence ID" value="ENSCJPP00005010152.1"/>
        <property type="gene ID" value="ENSCJPG00005008886.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000017457"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110016">
        <property type="term" value="C:B-WICH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042564">
        <property type="term" value="C:NLS-dependent protein nuclear import complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070888">
        <property type="term" value="F:E-box binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042149">
        <property type="term" value="P:cellular response to glucose starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032922">
        <property type="term" value="P:circadian regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072332">
        <property type="term" value="P:intrinsic apoptotic signaling pathway by p53 class mediator"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000210">
        <property type="term" value="P:positive regulation of anoikis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045945">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903450">
        <property type="term" value="P:regulation of G1 to G0 transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007015">
        <property type="entry name" value="DNA_pol_V/MYBBP1A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13213:SF2">
        <property type="entry name" value="MYB-BINDING PROTEIN 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13213">
        <property type="entry name" value="MYB-BINDING PROTEIN 1A FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04931">
        <property type="entry name" value="DNA_pol_phi"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="694"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1146"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="695"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1159"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1197"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1216"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1250"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1291"/>
            <end position="1300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005010152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1307" mass="147844" checksum="B248B3BB0564907E" modified="2022-01-19" version="1">MAWRTRQHLDPLHSTRYPGRGGAGSPTCRGGGMAEREARQGAGIPSDPRGVLRKGRAFLDLFWDIAKPEQGVRLEATENLLRHLKDGGELQYALKRLVEGLGATREAARPGFSLALAQVLKAFEEIPLCSVLEQIKEKHNLEKVKKKLVRNAAFGNFFGVMALFQSGRLIKDQKALLECMQLLQQLAHHQTHLRDLPSKTLVDILLEVPEAVFEEVLFGILQADLTSAFTSPENLHLLLVGMQKFPGVLKPKKLKKLFGSPTIVNEENIPRLVELLESAAKSEKKDKKLPSVGLDLLQVSLKEGAFELFWNEAVENGLFKEKSGPVSYMCFRLLGSALPLLSLDQLQMVLKGRVMQHYGEHVVTTQLPDRFKFAPEMEGYVDKFLTSCDDPERQLAVMIGFSTLTNQGYPVVPSIWRVVRHLQPEALQKYIDWLKDMFLRPDLDCCLDFTTNRQKQNHEYKNIAQHKIARLRKWIIHRLMSIVESPVKKEESLVMDISRFCFFHAFFETKKKTSQIPETNALISDPLDEQFSLHTLSLREKHIHGVTADGKLWIFHLVEYANELLSSEKYVKAVKPFTKEQRDAWERTLQTVENLQKKKSKSDSAKLFAFQQLLLLMAIHLFKVSSPNCCLSICSCAENEEPEWVEVIVEILLSLLAQPSLLIRRISNSVFGRICPNLTKKGLQLILDVSLVRDSEEDSSDDGDTEEENDSEDEKNEEVDEDFRSQLINVLQGGNALGEDDSDEELDDEAMMALDKNISALFAEQQKRIQAKKDEKDRIRKEKILRRDFKIKVLDLVEVFLNKQPENPLVFDIIEPLLHVIEQCMSSDSDKQEIDFLQKTAHIFTNSLCRAKQYCKKVDVLQDDLHAFVERLIKKACKHNDSSVALYYFSASLYLLKVLRGNVSDKPPAPPVPLSKKQTNTIPQACQVRAGCCQGNAFASKLALPCFAENALLIHTGCLDVERVTSIYQQALTQFLSKRNSALTSSMFLDLFTRFPWGICIANTFPLRASSFTSHVSSPFLFQAQACLLLQKVLPLRELKLSTTKEEWEELIRESISQVTEVRTFNTVKAEKEKVARCLELLNFLLKTATQQVRVGLILSCLYFLHHSCAPACLWLPATWIALLLALKRVALDFWCSLCRKPKKEKTANKPVQEAEPLKRKKKGFLPETKKRKNRKKAVRENGGAPAASEDGDSAAPDEKPLGTETPEQKDGRLPGSKKHRKRNRGVRENGVAAEGRENGAVNGEDAVAAKKRKKKKNRKRKGDAGNEAEQIPAAKKVKGDVNQETQQKQGKAKKKRKEKKSAVLQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YA13</accession>
    <name>A0A8C2YA13_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="25">Cytochrome P450 2U1</fullName>
            <ecNumber evidence="24">1.14.14.80</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="26">Long-chain fatty acid omega-monooxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="29" type="primary">CYP2U1</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="29" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="29" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="23">A cytochrome P450 monooxygenase involved in the metabolism of arachidonic acid and its conjugates. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Acts as an omega and omega-1 hydroxylase for arachidonic acid and possibly for other long chain fatty acids. May modulate the arachidonic acid signaling pathway and play a role in other fatty acid signaling processes. May down-regulate the biological activities of N-arachidonoyl-serotonin, an endocannabinoid that has anti-nociceptive effects through inhibition of fatty acid amide hydrolase FAAH, TRPV1 receptor and T-type calcium channels. Catalyzes C-2 oxidation of the indole ring of N-arachidonoyl-serotonin forming a less active product 2-oxo-N-arachidonoyl-serotonin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = 19-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:39759"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:32395"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:76627"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:39760"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:39755"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:32395"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:76624"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:39756"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin + reduced [NADPH--hemoprotein reductase] + O2 = 2-oxo-N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50296"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:132255"/>
            <dbReference type="ChEBI" id="CHEBI:132256"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:50297"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>an omega-methyl-long-chain fatty acid + reduced [NADPH--hemoprotein reductase] + O2 = an omega-hydroxy-long-chain fatty acid + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:56748"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:140991"/>
            <dbReference type="ChEBI" id="CHEBI:140992"/>
            <dbReference type="EC" id="1.14.14.80"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:56749"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 27">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 28">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.80" evidence="24"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2YA13"/>
    <dbReference type="Ensembl" id="ENSCJPT00005016232.1">
        <property type="protein sequence ID" value="ENSCJPP00005011065.1"/>
        <property type="gene ID" value="ENSCJPG00005009541.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157714"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052869">
        <property type="term" value="F:arachidonate omega-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0102033">
        <property type="term" value="F:long-chain fatty acid omega-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:omega-hydroxylase P450 pathway"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:xenobiotic metabolic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20666">
        <property type="entry name" value="CYP2U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000017">
        <property type="entry name" value="cytochrome P450 2U1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008069">
        <property type="entry name" value="Cyt_P450_E_grp-I_CYP2D-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF364">
        <property type="entry name" value="CYTOCHROME P450 2U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01686">
        <property type="entry name" value="EP450ICYP2D"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 27 28" id="KW-0349">Heme</keyword>
    <keyword evidence="14 27 28" id="KW-0408">Iron</keyword>
    <keyword evidence="16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="18" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 27 28" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0492">Microsome</keyword>
    <keyword evidence="17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15 28" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="13 28" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="27">
        <location>
            <position position="467"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00051320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00052159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00052378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00058812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00066560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00067282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00079181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005011065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="528" mass="59944" checksum="FBACADBDC7D08CCF" modified="2022-01-19" version="1">MAADGEWLLRAPTATELLLAAVCWLGCYWMLRPRAPPGLPPGPAPWPLVGNCAFALLPPPLLRRWVLEVWGRGPGSPVFSPHVFLTGLTKMYGSIFRLFVGSRPFIVLNTFGAVREALVQKAEVFSDRPSVPIVLLITHNKGVIFAPYGPVWKQQRKFSLATLRHFGVGRHSLEPKIIEELKFIKEEMLKHGKDSFNPFPIIRNAVSNVICSMAFGRRFNYEDVEFKTMLKNMARALELSVNSSMILVNICPWLYYLPFGPFRELRKTELDITAFLKQIIAQHRDTLDAANPRDFIDMYFLHAEEEKNNKESSFNEDYLFFIIGDLFIAGTDTTSNTILWCLLYMSLYPEVQEKVHAEIEAVLGRDKVPSLTHKAQMPFTEATIMEVQRMTAVVPLSIPRMASETAVLQGYTIPKGSVIVPNLWSVHRDPNIWENPDDFQPTRFLDENGQIIKKEAFIPFGMGKRVCMGEQLAKMELFLIFASLMQSFTFLYPENATKPSMEGSAVYHCQTEHRGSLFSEDSIHITTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YA39</accession>
    <name>A0A8C2YA39_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="26">Metalloendopeptidase</fullName>
            <ecNumber evidence="26">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="33" type="primary">MEP1B</name>
    </gene>
    <organism evidence="33 34">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="33" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="33" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="33" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>Hydrolysis of proteins, including azocasein, and peptides. Hydrolysis of 5-His-|-Leu-6, 6-Leu-|-Cys-7, 14-Ala-|-Leu-15 and 19-Cys-|-Gly-20 bonds in insulin B chain.</text>
            <dbReference type="EC" id="3.4.24.63"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="25 26">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="25 26">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="21">Homotetramer consisting of disulfide-linked beta subunits, or heterotetramer of two alpha and two beta subunits formed by non-covalent association of two disulfide-linked heterodimers. Interacts with MBL2 through its carbohydrate moiety. This interaction may inhibit its catalytic activity. Interacts with TSPAN8.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="24">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="26"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2YA39"/>
    <dbReference type="Ensembl" id="ENSCJPT00005016876.1">
        <property type="protein sequence ID" value="ENSCJPP00005011544.1"/>
        <property type="gene ID" value="ENSCJPG00005009919.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107310133"/>
    <dbReference type="KEGG" id="cjo:107310133"/>
    <dbReference type="GeneTree" id="ENSGT00950000183111"/>
    <dbReference type="OrthoDB" id="291007at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017090">
        <property type="term" value="C:meprin A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00053">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06263">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03782">
        <property type="entry name" value="MATH_Meprin_Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04282">
        <property type="entry name" value="ZnMc_meprin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000363">
        <property type="entry name" value="Meprin A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000037">
        <property type="entry name" value="Meprin A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.210.10:FF:000009">
        <property type="entry name" value="Meprin A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000015">
        <property type="entry name" value="Meprin A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000998">
        <property type="entry name" value="MAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008294">
        <property type="entry name" value="Meprin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034038">
        <property type="entry name" value="ZnMP_meprin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF814">
        <property type="entry name" value="MEPRIN A SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00629">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001196">
        <property type="entry name" value="Meprin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00020">
        <property type="entry name" value="MAMDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00137">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00740">
        <property type="entry name" value="MAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50060">
        <property type="entry name" value="MAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 24" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="18" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 25 26" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="19" id="KW-0395">Inflammatory response</keyword>
    <keyword evidence="15 28" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 23 25" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14 25 26" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7 25 26" id="KW-0645">Protease</keyword>
    <keyword evidence="34" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 26" id="KW-0732">Signal</keyword>
    <keyword evidence="8 28" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 28" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12 23 25" id="KW-0862">Zinc</keyword>
    <keyword evidence="16" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="26">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034972088" description="Metalloendopeptidase" evidence="26">
        <location>
            <begin position="20"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="726"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="32">
        <location>
            <begin position="63"/>
            <end position="257"/>
        </location>
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    <feature type="domain" description="MAM" evidence="30">
        <location>
            <begin position="264"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="MATH" evidence="31">
        <location>
            <begin position="428"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="29">
        <location>
            <begin position="676"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="615"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="27">
        <location>
            <begin position="623"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="active site" evidence="22 25">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
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        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
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        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
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        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
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            <dbReference type="ARBA" id="ARBA00004613"/>
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            <dbReference type="ARBA" id="ARBA00022475"/>
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            <dbReference type="ARBA" id="ARBA00022525"/>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022670"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
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            <dbReference type="ARBA" id="ARBA00022692"/>
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            <dbReference type="ARBA" id="ARBA00022801"/>
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            <dbReference type="ARBA" id="ARBA00022833"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
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            <dbReference type="ARBA" id="ARBA00023180"/>
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            <dbReference type="ARBA" id="ARBA00051946"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="775" mass="87195" checksum="03FF905C910127D8" modified="2022-01-19" version="1">MDWLSVLVLLSCLLQVVWNQPALETTEVDIDGGIDQDIFDINEALGLDLFEGDIKLDRMQERNSIIGDEYRWPHVVPYVLEDSLEVNAKGVILKAFEQYRLKTCIDFKPWEGEENYISVFKGSGCWSSVGNRQQGLQQLSIGANCDRIATIEHEFLHALGFWHEQSRSDRDDYVSIIWDRIQTGREHNFNKYDDKTSDSLNVPYDYTSVMHYSKTAFRNGTEPTIVTNIPYFMDVIGQRMDFSDSDLQKLNQLYNCSSSLIFMDTCSFELENICGMIQSSDDNSDWQHLSHVPAGPNTDHTNMGECEDSGYFMHFNTSAVAGGSTAILESRILYPKRGFQCLQFYFYNSGSESDQLYVWVREYSDAHPNGTLRLIEEIKGSPVNYWQLHHVSLNVTSKFRVVFQGVRGTGLSNGGLSIDDINLSETQCPHHVWHIRNFTDLLNTSPAGTAGKIYSPPFYSSKGYAFQVGLYINGTIDSPFNLGIYLYLISGANDDQLQWPCAWQQVTMILLDQHPDIRQRMSNQRSVTTDPLELSDSSSNYFWDRPDKVGSAASFPNGTTFMRGPGRGTSAFITHQRLRSRDFIKEGGVYVLLTMEDVSHLVSAQPSVPPTVVMNSTDSAVRPTPIANTTTTRPTTRTTTTTKPTTTTRPTDKPTAAKTPIPTLLVTLTEKPEMDTPESCPDNPCENDGVCVIVDRKAVCRCPSGNNWWYMGERCERKGTTQENTIIAVSSTITVFVVMLIVTITTVVCLKKKYSKGEGKEKAESLSLEENKTSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YAD3</accession>
    <name>A0A8C2YAD3_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Potassium channel subfamily K member 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">KCNK9</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015711892.1">
        <property type="nucleotide sequence ID" value="XM_015856406.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YAD3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005017201.1">
        <property type="protein sequence ID" value="ENSCJPP00005011797.1"/>
        <property type="gene ID" value="ENSCJPG00005010102.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107310598"/>
    <dbReference type="KEGG" id="cjo:107310598"/>
    <dbReference type="CTD" id="51305"/>
    <dbReference type="GeneTree" id="ENSGT00940000159791"/>
    <dbReference type="OrthoDB" id="297496at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005272">
        <property type="term" value="F:sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071468">
        <property type="term" value="P:cellular response to acidic pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000859">
        <property type="term" value="P:negative regulation of aldosterone secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099605">
        <property type="term" value="P:regulation of action potential firing rate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060075">
        <property type="term" value="P:regulation of resting membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000057">
        <property type="entry name" value="Potassium channel subfamily K member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003092">
        <property type="entry name" value="2pore_dom_K_chnl_TASK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005407">
        <property type="entry name" value="KCNK9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF75">
        <property type="entry name" value="POTASSIUM CHANNEL SUBFAMILY K MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01585">
        <property type="entry name" value="TASK3CHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01095">
        <property type="entry name" value="TASKCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14 15" id="KW-0407">Ion channel</keyword>
    <keyword evidence="11 15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0630">Potassium</keyword>
    <keyword evidence="8" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="6" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="314"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="18">
        <location>
            <begin position="171"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="18">
        <location>
            <begin position="262"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="35"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005011797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="468" mass="52808" checksum="E69F55E08140CE50" modified="2022-01-19" version="1">MALRTGTAWFGQVLRRVSRLQGTWSRRSSSLLCLSSSQEPEQAGGERPQPQHKLPRSSRQPPRQLPHCCGCCGLSDPRAARGGHGPLTRPLLAAMKRQNVRTLSLIICTFTYLLVGAAVFDALESDNEMREEEKLKAEEIRLKGKYNITSEDYRQLELVIMQSEPHRAGVQWKFAGSFYFAITVITTIGYGHAAPGTDAGKAFCMFYAVLGIPLTLVMFQSLGERMNTFVKYLLKRIKKCCGMRSTEVSMENMVTVGFFSCMGTLCIGAAAFSQYEEWSFFHAYYYCFITLTTIGFGDYVALQTKGALQKKPLYVAFSFMYILVGLTVIGAFLNLVVLRFLTMNSEDERRDAEERASLAGNRNSMIIHIQEDSQHGRPRYKAEVTDLQSVCSCMCYRSHEYTSRVVSHQNSFSSKLNPQYFHSISYKIEEISPSTLKNSLFPSPVSSISPGLHSFTDNHRLMRRRKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YBJ8</accession>
    <name>A0A8C2YBJ8_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">EBF transcription factor 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">EBF2</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the COE family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_032304777.1">
        <property type="nucleotide sequence ID" value="XM_032448886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YBJ8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005020750.1">
        <property type="protein sequence ID" value="ENSCJPP00005014599.1"/>
        <property type="gene ID" value="ENSCJPG00005011991.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107323697"/>
    <dbReference type="CTD" id="64641"/>
    <dbReference type="GeneTree" id="ENSGT00950000182859"/>
    <dbReference type="OrthoDB" id="25246at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060612">
        <property type="term" value="P:adipose tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001709">
        <property type="term" value="P:cell fate determination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120162">
        <property type="term" value="P:positive regulation of cold-induced thermogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd11606">
        <property type="entry name" value="COE_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01175">
        <property type="entry name" value="IPT_COE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.4280:FF:000001">
        <property type="entry name" value="transcription factor COE1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.3180:FF:000002">
        <property type="entry name" value="transcription factor COE2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001696">
        <property type="entry name" value="Transcription factor COE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3180">
        <property type="entry name" value="Transcription factor COE1, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032200">
        <property type="entry name" value="COE_DBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038173">
        <property type="entry name" value="COE_DBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032201">
        <property type="entry name" value="COE_HLH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038006">
        <property type="entry name" value="COE_IPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003523">
        <property type="entry name" value="Transcription_factor_COE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018350">
        <property type="entry name" value="Transcription_factor_COE_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10747">
        <property type="entry name" value="TRANSCRIPTION FACTOR COE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16422">
        <property type="entry name" value="COE1_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16423">
        <property type="entry name" value="COE1_HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00429">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01345">
        <property type="entry name" value="COE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0010">Activator</keyword>
    <keyword evidence="3 12" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="IPT/TIG" evidence="14">
        <location>
            <begin position="252"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="441"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="441"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="454"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005014599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="584" mass="63825" checksum="265ECE1C08A1B566" modified="2022-01-19" version="1">MFGIQDTLGRGPILKDKTLGSEMDSVRSWVRNVGVVDANVAAQSGVALSRAHFEKQPPSNLRKSNFFHFVLALYDRQGQPVEIERTAFVDFVENDKEQGNEKTNNGTHYKLQLLYSNGVRTEQDLYVRLIDSVTKQPITYEGQNKNPEMCRVLLTHEVMCSRCCEKKSCGNRNETPSDPVIIDRFFLKFFLKCNQNCLKTAGNPRDMRRFQVVLSTTVNVDGHVLAVSDNMFVHNNSKHGRRARRLDPSEATPCIKAISPSEGWTTGGAMVIIIGDNFFDGLQVVFGTMLVWSELITPHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGAPGRFIYTALNEPTIDYGFQRLQKVIPRHPGDPERLAKEMLLKRAADLVEALYGTPHNNQDIILKRAADIAEALYSVPRNPAQIPALSSSPAHSSMMGINSYGSQLGVSISESTQGNNQGYIRNTSSISPRGYSSSSTPQQSNYSTSSNSMNGYSNVPMSNLGVPGSPGFINGSPTGSPYGIMSSSPTVGSSSTSSILPFSSSVFPAVKQKSAFAPVIRPQGSPSPACSSGNGNGFRGKKCTINIQLAYTKHTVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YBV4</accession>
    <name>A0A8C2YBV4_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Iroquois homeobox 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">IRX6</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TALE/IRO homeobox family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2YBV4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005021160.1">
        <property type="protein sequence ID" value="ENSCJPP00005014924.1"/>
        <property type="gene ID" value="ENSCJPG00005012397.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159909"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000003">
        <property type="entry name" value="Iroquois-class homeobox protein IRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11211:SF47">
        <property type="entry name" value="IROQUOIS HOMEOBOX PROTEIN 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11211">
        <property type="entry name" value="IROQUOIS-CLASS HOMEODOMAIN PROTEIN IRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="329"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="331"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="37"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="137"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="392"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="174"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="402"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="441"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="492"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="502"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="520"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="586"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005014924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="619" mass="65358" checksum="0517C72F520F3F34" modified="2022-01-19" version="1">MSRSCCVRLKQIARTSHSEKRLGNRCFLPPLPFHRSLGSATNKHTRGRSVPPRRVLRAPLPAEPPSDPGAPRTATRVGWDGSGAASAARCVCLPRSGSSPSLSTSPNRVPSIALADIFTALSIVELTAIATSCLEIDANGPRGAGRGEPRGSLDVFERDRSLRVPPAPLRASPLPAPGAPPPPPAPAAPGLPRGRSALPVSPSQFLVPGSPGASCCEPAPRSGPDASSAPAAASLCCAPYESRLLAPGRAELNAALGMYGAPYAAGQGYGNYLPYSAEPAAIYTALNPQYEIKEGASTLHSGIAQPAAYYSYEHSLGQYQYDRYGPVDFTASARRKNATRETTSTLKTWLYEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWSPKNKAGEERKEDGTRHDGEYGAGSDGREPKSCKEDKELRLSDLDDLEEEDEEDEDEEEAGKAANGRPGSLQEAPGPRSACSVPGPCRAFPCSRAPTAAPAPAALAPPPPYAPPEKPRIWSLARTAGANATRRGSPEGRGTEEGGGTTAELPPTPDAPFRSSAFSPQPVPRSCASHRGLGQPCQYAAGEGFGRGGGGGPGGAEPGGTCLERLRTAFRPVLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YCL9</accession>
    <name>A0A8C2YCL9_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Class A basic helix-loop-helix protein 15</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Class B basic helix-loop-helix protein 8</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Muscle, intestine and stomach expression 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">BHLHA15</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="8">Forms homodimers or heterodimers with TCF3 gene products E12 and E47. These dimers bind to the E-box site, however, heterodimer with MYOD1 does not bind target DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2YCL9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005023231.1">
        <property type="protein sequence ID" value="ENSCJPP00005016546.1"/>
        <property type="gene ID" value="ENSCJPG00005013578.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161824"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070888">
        <property type="term" value="F:E-box binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061564">
        <property type="term" value="P:axon development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044331">
        <property type="term" value="P:cell-cell adhesion mediated by cadherin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045216">
        <property type="term" value="P:cell-cell junction organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007267">
        <property type="term" value="P:cell-cell signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042149">
        <property type="term" value="P:cellular response to glucose starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051649">
        <property type="term" value="P:establishment of localization in cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002071">
        <property type="term" value="P:glandular epithelial cell maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042593">
        <property type="term" value="P:glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051674">
        <property type="term" value="P:localization of cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006851">
        <property type="term" value="P:mitochondrial calcium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010832">
        <property type="term" value="P:negative regulation of myotube differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007423">
        <property type="term" value="P:sensory organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072560">
        <property type="term" value="P:type B pancreatic cell maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd19711">
        <property type="entry name" value="bHLH_TS_MIST1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000065">
        <property type="entry name" value="class A basic helix-loop-helix protein 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050359">
        <property type="entry name" value="bHLH_transcription_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19290">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19290:SF160">
        <property type="entry name" value="CLASS A BASIC HELIX-LOOP-HELIX PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="13">
        <location>
            <begin position="71"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00064489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00076138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00077672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005016546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="194" mass="21560" checksum="93184C4263003208" modified="2022-01-19" version="1">MDPGPALRAGGARAAPMDAAAAPGFSQSAMRKKELGKCVRHTERRSGGSRESSKIAAARAKCPWSSKDRHLRRLESNERERQRMHKLNNAFQALREVIPHVRAENKLSKIETLTLAKNYIKSLTSIILNMSNGHFPAAEGLGGSWGPKLYQNYQQQLQGTGTAPSSVLSLSLLRSEPKGYCERYIWGKCRDREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YD94</accession>
    <name>A0A8C2YD94_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">V-set and immunoglobulin domain containing 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">VSIG10</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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            <end position="1558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005018382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1785" mass="197595" checksum="65CD1730CD46221D" modified="2022-01-19" version="1">MTSLKRSQTERSVATGVSVGTDGTTKVHSDDFYMRRFRSQNGSLGSAVMAPVGPPRNESSHHVTSTPGVPKMGVRARIADWPPRKENIKETSRSSQDIETASCLDSMSSKSSPGSQGSSVNLNASDSVMLKSIQNTLKSKTRQSENLDSRFLTPDGYPSSPRKALRRIRQRSNSDITISELDVDSFDECISPTFKSGPSLHREYGSTSSIDKQGTSGESFFDLLKGYKDEKSDQRSPGTTKLSELLIASGSKGSGFSLDVIDGPITQRENLRLFKEREKPLKRRSKSETGDSSIFRKLRNAKGEGDLGKSSDLEDNRSEDSVKPWTCPKCFAHYDVQSILFDLNEAAINRHNVIKRRNTTTGASAAAVASLVSGPLSHSASFNSPMGSTEDLNSKGSLNMDQGDDKSNELVMSCPYFRNEIGGEGERKISLSKSNSGSFSGCESASFESTLSSHCTNAGVAVLEVPKENLILHLDRVKRYIVEHVDLGAYYYRKFFYQKEHWNYFGADENLGPVAVSIRREKPEEIKENGPQYNYRIIFRTSELMTLRGSVLEDAIPSTAKHCTARGLPLKEVLEYVVPELNIHCLRLAFNTPKVTEQLMKLDEQGLSYQLKVGIMYCKAGQSTEEEMYNNESAGPAFEEFLQLLGERVRLKGFEKYRAQLDTKTDSTGTHSLYTTYKDYEIMFHVSTMLPYTPNNKQQLLRKRHIGNDIVTIVFQEPGAQPFSPKNIRSHFQHVFVIVRVHGPCTDSVCYSVAVTRSRDVPSFGPPIPKGVTFPKSNVFRDFLLAKVINAENAAHKSEKFRAMATRTRQEYLKDLAEKNVTNTPIDPSGKFPFISLASKKKEKSKPYPGAEIYSSGAIVWSVHAKDYSKGMEIDCLLGVSNEFVVLIEQDTKSVVFNCSCRDVIGWTSTDTNIKIFYERGECVSLESFISNIDDIKEIVKRLELVTKGCETVEMTLRRNGLGQLGFHVNYEGIVADVEPYGYAWQAGLRQGSRLVEICKVAVATLSHEQMIDLLRTSVTVKVVIVPPYEDCTPRRSCSENYRMPVMEYKVNEGMPYEFKFPFRNNNKWQRNTNKGQGPHVAQVPSQVQSPVPSRIGSGKGEGKMPPPERAANIPRSISSDGRPLESRRLSPGSDVYVTVSSIALARSQQCRNSPSNLSTSSETGSAGSTYRQKSMPEGFGISRRSPASIDRQSTQSDTGGSGKSTPSWQRSEDSIADQMEPTCHLPAVSKVLPSFRESPSGRLMRQDPVVHLSPNKQGHSDSHYSSHSSSNTLSSNASSAHSDEKWYDSGERTESELNSYNYLQGTSADSGIDTTSYGPSHGSTASLGAATSPRTGLTKEKVTPLWHSSSEVVSIADRTLEKESHIDRKAESSLSLDIHSKSQPASNPLTRENSAYSLSDAVSHTSTMSSRHSASPVVFTSARSSPKEELHSATSPQLAPSFSSSSSSSSGPRTFYPRQGATSKYLIGWKKPEGTINSVGFMDTRKRHQSDGNEMAHPRLRASARDLRASPKRASKSTVEEDLKKLIDLDSPTPESQKNFKSHTLSCQSPFPSTPTTRRALQRTLSDESIYSGQRDHFFASRASLLDQAMPNDVLFTSTYPSLPKSLPLRRPSYTLGMKSLHGEFSASDSSLTDIQEQRRQPMPDPGLMPLPDSASDLDWSNLVDAAKAFEVQRASFFAVADENHRPVSAASSGDQAEDQLTAQIKPYTGKESPPTLASKVDQLEGLLKMLQEDLRKEKEDKANLQAEVQHLREDNLRLQEESQNATEKLKKFTEWVFNTIDMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YF79</accession>
    <name>A0A8C2YF79_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Holliday junction recognition protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">HJURP</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015733249.1">
        <property type="nucleotide sequence ID" value="XM_015877763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YF79"/>
    <dbReference type="Ensembl" id="ENSCJPT00005030296.1">
        <property type="protein sequence ID" value="ENSCJPP00005022081.1"/>
        <property type="gene ID" value="ENSCJPG00005017648.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107321145"/>
    <dbReference type="KEGG" id="cjo:107321145"/>
    <dbReference type="CTD" id="55355"/>
    <dbReference type="GeneTree" id="ENSGT00390000005575"/>
    <dbReference type="OrthoDB" id="9948556at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15992">
        <property type="entry name" value="HOLLIDAY JUNCTION RECOGNITION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15992:SF5">
        <property type="entry name" value="HOLLIDAY JUNCTION RECOGNITION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="716"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005022081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="769" mass="87286" checksum="021CEFE4C5653CD2" modified="2022-01-19" version="1">MALDLDGRLRRSKDRFQTSILSILERYNYPFEDDFLVSIETLTYDTPDGPKQWGELSLQELRKLFKRHVRSKRTEDQTVGEESDAEIVRRRFEDIHVQSLDEDDAEVGKKVQVQVDVIVQDDERRIPKWITLTPSSSHCTSPARGLLGNKSSPCRNKAELANECSSSSPHQLQLSDVPMLPDVITLPRHQSFQEMNETCYNSTLEEYQSADEGCSWSNVTLADLYPKMVEVLTKLMTRENRIKAFKYMFRLHRHKRGHGKRPKLSITVEKIKKFRPLKLKKSLPSICSSSEDIQNQTFGNNVNKNSRPCDNQCFINNSSGLVPFSRSDTSEMEMDCSDSSSDYHLVSGKDQRLSELIAVPNALARIGETFLAEDQLQTTVSWNSSKYNKSGNLTYKHSLKPPFRTSASSGSAVHHLDKESKTQKNDFPSNDTSGFCSSTCSIVSDSNTLTPVKDCYLASGALLINPEIKIFEKQNCLQRRHSFSSLSVKQSPSKTPQKYEDAFEKLYYKLCSRGSQKPLTLTKLPSSSHKLEEKGGIVKNTFSDSLRSNIQYDIAFEKIYQQLSTEVVPKIPGFQRASNLRKYEGIQMSETVNALVNSPIRSLYAIPRVKRLGNFQNDLLSSPVKRLKNIPEHFFSTECQQISHKKYGDLQTVGMDFVSLHNRSSTRFFNGRNCHHQDSGFHASSDKTFLVIPDDSLKESEYAHVCCSSPRAIPNYSSPQNALKHPQKVSRKLSYTDGKDRNPSNPLDDASIKTHQGTFMAYRENGFVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YFX8</accession>
    <name>A0A8C2YFX8_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="Ensembl" id="ENSCJPT00005032381.1">
        <property type="protein sequence ID" value="ENSCJPP00005023654.1"/>
        <property type="gene ID" value="ENSCJPG00005018728.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183199"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11852:SF4">
        <property type="entry name" value="LITTLE ELONGATION COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11852">
        <property type="entry name" value="PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1523"/>
            <end position="1563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1527"/>
            <end position="1536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1537"/>
            <end position="1547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005023654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1687" mass="185953" checksum="65798358672080F4" modified="2022-01-19" version="1">MNTELLGSDCLKNKATEDYLQGCEDNAIDAIVQRDRTHSSSAFSDQEQKGQGGNVIDILNWVRPLPALLSPVRLSPVATQDVLFGELTDSSDEEVDCTASAVECILQEDQVQPQNCCNLFKPNEEYNKWNKPHGHSLDAEISHNSSGTEKIVHIGPETFIKEERNTKQCEAETSVTNIESNRDYLEENSENIETTKGDLMEATACELETKEEWKGDIKEINDEERASSVHSMLHSFDLQNKIERCSEFEQTEEKAILVRTSAYEGTHEKYGELMKVEHEREIPKALSIPHNVTHLPPEQYLQRKDSEEKSGMLLESEVVEIECKDAMKLTNMAVNVEENIKEVVTGEEATAAVQMQGLCAEPNNERELSENILYNFSSSESSCKDKCPENLIVQCDGEGIVVETDECTESTEISVCSQCFEIRHDSAKIMEGKCTHTLKCEIVRKCELETDQVSQCYLPVSAVEGIEHALYTDDTDKKVCVVGNASSAFPDDDGQLRIQDINIIKPKSAEPTTKLNKESVLEIAESSGLLHSAQNGKLLYEKGREDLKGENHQEESYSNFFQGKSDFESIPEVPKVACITDAESSVVKCESPVMDFTERNGEIKQPENLCSTLEYGLSTTQNFRAIESQETEFKVNRDFTGESSELLEEEDTIQSVLVESNLSSQTQFGKPQNQVLVTTNTKCDETKAEFNRQSKELIEACPSSCEEEKNVVKKNNVSEIVEQPSPEMDFNSGFALCSQMDLKTDCINSKETGSPVQAGNGLESAVPSDLNFSLQKVVGVVETNLTENSDVSSTWEKKGDKNCIVSSAFNCSLEGFKKDAEIISTKKVNICKELDSCSEKYMHKNEGEVPGEKELPVDKEPETSVELQILHAGSHEKNTLTFQNSICQESECKISTQEARTDSSRTCSLTAGRKSEGLNCFEASEENSIKSSKNAFDIAEQSNESKEKDCPLQSVRCVKCSEYMFRKELRASTRIVVDALKAGAVVDADDQPHEFHSTVHSGNTATDSCLKPDAVMDMDIHCEIGSSPNAASEKTVVVEEGYPKDYSELKRECTLVASENTDGASEFRVDNSITGRMSDSREDLLKTEAFKGSPVMLSASKSRLPLRQMLTTFSEAYRIAVKHNKLDTRMLELGSFVEENYSKKFESDVQRLPHSVDMDISIFEEYNHNQNCSACNSGENNTNVMLDGLHHSCCFSGTAWKDFLDSGRKNLIVKYFANPALSDINCNSQMVSQASKPQKMVFEDSRMLESESSVDVALKKTNKLNCKGQEQSEVLSVSTKTAVQVMHGRLSKKLFQGKRKTSALEAKVTEPVVANADTSMPAKCSSETINKIRQELGPPLPPLLLPLIASPPRATAHSMGSVMSSADRSSLLSPLDELISPLHESPVPPLMSPLTDTPTVKSALLFSSPSPSEMTVGKRILSSPLQFCTSIPKHALPVPGRLPLCAADGAAAGAPQENSVKILDTMYPELSARARTLNILKGNIQLNLCALSDSHSSPGPVAQIGGFKTIASTSTAFVKTGSNLKSDGSKDQDKNVKNQQLISSSSSRLEKRTLLPVPMPKSAKRLRLDSEPPKLEPTDIATNRNGQNTVSEVEENFDVESCEISDSAHSCSLETSLPVKEIVDPGCEKVDLALKKIAESCFDLLPVIESNLGSISKIPIMRDEEKEVVNEFGIKNKVSSIILSFVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YG73</accession>
    <name>A0A8C2YG73_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Alpha-2-macroglobulin-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC107325044</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015741014.1">
        <property type="nucleotide sequence ID" value="XM_015885528.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005033063.1">
        <property type="protein sequence ID" value="ENSCJPP00005024230.1"/>
        <property type="gene ID" value="ENSCJPG00005019132.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107325044"/>
    <dbReference type="KEGG" id="cjo:107325044"/>
    <dbReference type="GeneTree" id="ENSGT00940000154904"/>
    <dbReference type="OrthoDB" id="9998011at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02897">
        <property type="entry name" value="A2M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000001">
        <property type="entry name" value="CD109 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1930:FF:000001">
        <property type="entry name" value="CD109 isoform 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.130.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1930">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.690">
        <property type="entry name" value="Alpha-macroglobulin, receptor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009048">
        <property type="entry name" value="A-macroglobulin_rcpt-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036595">
        <property type="entry name" value="A-macroglobulin_rcpt-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050473">
        <property type="entry name" value="A2M/Complement_sys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011625">
        <property type="entry name" value="A2M_N_BRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041813">
        <property type="entry name" value="A2M_TED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047565">
        <property type="entry name" value="Alpha-macroglob_thiol-ester_cl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011626">
        <property type="entry name" value="Alpha-macroglobulin_TED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001599">
        <property type="entry name" value="Macroglobln_a2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019742">
        <property type="entry name" value="MacrogloblnA2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002890">
        <property type="entry name" value="MG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041555">
        <property type="entry name" value="MG3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040839">
        <property type="entry name" value="MG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412:SF185">
        <property type="entry name" value="ALPHA-2-MACROGLOBULIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412">
        <property type="entry name" value="MACROGLOBULIN / COMPLEMENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00207">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07703">
        <property type="entry name" value="A2M_BRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07677">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01835">
        <property type="entry name" value="MG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17791">
        <property type="entry name" value="MG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17789">
        <property type="entry name" value="MG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07678">
        <property type="entry name" value="TED_complement"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01360">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01359">
        <property type="entry name" value="A2M_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01361">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01419">
        <property type="entry name" value="Thiol-ester_cl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49410">
        <property type="entry name" value="Alpha-macroglobulin receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00477">
        <property type="entry name" value="ALPHA_2_MACROGLOBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034043492" evidence="9">
        <location>
            <begin position="25"/>
            <end position="1475"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-2-macroglobulin bait region" evidence="10">
        <location>
            <begin position="450"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-2-macroglobulin" evidence="11">
        <location>
            <begin position="754"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-macroglobulin receptor-binding" evidence="12">
        <location>
            <begin position="1372"/>
            <end position="1459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005024230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1475" mass="163084" checksum="FD5F5B49C994FCC2" modified="2022-01-19" version="1">MKSPAAPTWLLLLILQLTIGSSEALYYVVTSPPVFYYPYSATLWVHLSNVHQPTQVTIQLQRAGGAGNITLLERKVEEPQLLLNVTFPTPAPSKGKEEIAHLHVSIEGDSLNTTKKSVMLRALEPGIFIQTDKAVYKPGQQVKFRIVSLDKDLVASDKKLPLVFLKDPRGNRIAQWRDVSPQQGIVDLSLPLAAEPALGTYTIHVERKTHSFTVEEYVLPKFEVTIDLPPTVWEKDEKFHLKICGRYTYGKPVQGKVHASLCQPWSFRGYPFALEENKDICTEVGGQTEKNGCFSTEVMMSSFNLNNYRLRKEVHVKASLVEEGTGVEMNNTKTCKILEKIFTVTFEDSDDFYKRGLPYTGTMQLKRADGSALGGQQLVVLVNNKERHSFLTDESGRASFELDTSGWTNKVSLVGEVNTSTSSQNGSSPPAFNSAYLNLRPFFSKSQSFLHIRRLEGKLFCSQSEQLQVDYILNKEALGSELQSLDVVFLVMAKGTIANILRKELPLGAGLKGSFSMELPTSPELAPTATVLGYAVLPNGEMLAGSTRLDVLNCLPNKVKMAFSKERALPGSALRMELTAAPGSLCAIRAVDRSVLLLKPEAELTTAEIYKVLPRFDYPGSIQELPPCTRWYHHRIYFTDVIARGPEGARLSKRSILGPYWDDLEINPYKLFQKAALKLLTNAKTMHDCEEFYRPYMHVMMGTPGRVAARVTEDMVDMRMLENRVQTMPVLAAAPAAPSNEEETVAPRTHFPETWLWDLVPVGEEGTAEMAMTVPDAITEWKAEMFCTAPVGLGLAPATTLTVFKPFFVDLALPYAVIRGEAFSLVATVFNYLRQCLRVQVTLADSVELEVSAVEGVTYSSCICADEAKTFRWDVKATNLGEVNITVSTEAISSEELCGNEQPVVPAQGRVDTVIKPLLVQPGGILVEKAHSSLICQEASEEVSLELPANILEGSQRAHVLVMGDIMGNALQNVDRLLAMPYGCGEQNMVRFAPNIYIQQYLEKSGQMNPDIRAKAQSFLQSGYQRELLYKHSDGSYSAFGERDDSGNTWLTAFVLKSFGQARAFVAIEERHITDALQWLQKQQQESGCFRSVGKLFNNALQGGVSDELSLSAYVTAALLELGMSPKDPVVISALKCLEASSTDNVYTEALMAYVYGLAKHEQQQARLQCLLQRGTSADGLLFWKRKDKALSTESLWAEAAPAEVEMTAYVLLAFLTQPQVSQADMARAAQIVRWLSKQQNPYGGFASTQDTVVALQALAKYATLTYSNNGDLAVTVTSPTGSKQDFVLEASNRLVLQQAALHELPGQYGVKTQGQGCALVQVTLRYNMPPPPSTGTFNLSVETEPKTCTSDASTHFRLLLRARYTGNRAATNMVVIEAKMPSGYIPDKSSVVELKRQKLVKKVEVQSDQVTIYLDQLTNEEETFSFAATQDFPVRNLQPATVTLYDYYETGDRTDAAYSAPCSSEADKQAKENF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YGF2</accession>
    <name>A0A8C2YGF2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Secernin-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">SCRN2</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C69 family. Secernin subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2YGF2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005033510.1">
        <property type="protein sequence ID" value="ENSCJPP00005024615.1"/>
        <property type="gene ID" value="ENSCJPG00005019389.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000013474"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070004">
        <property type="term" value="F:cysteine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.60.10:FF:000001">
        <property type="entry name" value="Secernin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.60.10">
        <property type="entry name" value="Penicillin V Acylase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005322">
        <property type="entry name" value="Peptidase_C69"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12994">
        <property type="entry name" value="SECERNIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12994:SF16">
        <property type="entry name" value="SECERNIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03577">
        <property type="entry name" value="Peptidase_C69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00040986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005024615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="497" mass="54597" checksum="EA13799BD7CDF1AF" modified="2022-01-19" version="1">MRGAEPGGEGDPLGDLGTGGNGGGPVPPPCDLRPPGAAVGRTGWDGAGMRGAEPGGEGRRRRGNSGRTGGWRVRMAGQDPGPSSCDCFVALPPHTAAPFVIFGKNADRPRHEVQEIVHIPSRIHPPGDKVRCTYIEIQQVERTHAVVLSRPAWLWGAEMGANEHGVCVGNEGVWTREPIGEDEALLGMDLVRLGLERGGSAKEALEVMTALLEQHGQGGSCKEEPIPFVYHNTFLLADRHEAWVLETAGRYWAAQRIREGSRNISNQLSIGTDITAEHPELRQRARSQGWWNGDGQFSFAEVFSLEKQPPRMEAAKTRYRAGKELLQLHAGRITAETFMAILRDKASGICVDSEGFRTAGSMVSILPQDPALPCIHFFTATPDPSRSVFKPFIFVPGLKPVPQVCSPTFSNDPAKKVPRFQSTVDRRHELYRRHQAALELMEKDQEQGKKLLQTLRELEKQGLDAVNALLEGNVAPRLEELAELFFDCVDAEMKFYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YGI6</accession>
    <name>A0A8C2YGI6_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Aspartate aminotransferase</fullName>
            <ecNumber evidence="14">2.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">GOT1</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(2S)-2-aminobutanoate + 2-oxoglutarate = 2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:70223"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:74359"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:70225"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>3-sulfino-L-alanine + 2-oxoglutarate = 3-sulfinopyruvate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:70295"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:61085"/>
            <dbReference type="ChEBI" id="CHEBI:140699"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:70297"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21824"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="EC" id="2.6.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:21825"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-cysteine + 2-oxoglutarate = 2-oxo-3-sulfanylpropanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:17441"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57678"/>
            <dbReference type="EC" id="2.6.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:17442"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 14">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="14">In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.1" evidence="14"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2YGI6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005033805.1">
        <property type="protein sequence ID" value="ENSCJPP00005024819.1"/>
        <property type="gene ID" value="ENSCJPG00005019532.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183082"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120554">
        <property type="term" value="F:2-aminobutanoate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047801">
        <property type="term" value="F:L-cysteine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006532">
        <property type="term" value="P:aspartate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032869">
        <property type="term" value="P:cellular response to insulin stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055089">
        <property type="term" value="P:fatty acid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006114">
        <property type="term" value="P:glycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006533">
        <property type="term" value="P:L-aspartate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019550">
        <property type="term" value="P:L-glutamate catabolic process to aspartate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043490">
        <property type="term" value="P:malate-aspartate shuttle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051384">
        <property type="term" value="P:response to glucocorticoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000044">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000001">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006719">
        <property type="entry name" value="PRK09257.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF3">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 14" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="16">
        <location>
            <begin position="75"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00036027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005024819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="456" mass="50107" checksum="2EE977C2FCDFE178" modified="2022-01-19" version="1">MGGVCPGSSPIGGAAPQPRPPAEGEGLLQELRGGCCAPCGTGSAMAASIFAPVPRAPPVAVFKLTADFREDGDSRKVNLGVGAYRTDEGQPWVLPVVRKVEQLIAANTSLNHEYLPILGLPEFRANASRIALGDDSPAIAQKRVGSVQGLGGTGALRIGAEFLRRWYNGNNNTATPVYVSSPTWENHNSVFMDAGFKDIRTYRYWDAANRGLDLQGLLDDMEKAPEFSIFILHACAHNPTGTDPTPDQWKQIAAVMKRRCLFPFFDSAYQGFASGSLDKDAWAVRYFVSEGFELFCAQSFSKNFGLYNERVGNLTVVGKDEDNVQRVLSQMEKIVRTTWSNPPTQGARIVATTLTSPQLFAEWKDNVKTMADRVLLMRSELRSRLESLGTPGTWSHITDQIGMFSFTGLNPKQVEYMIKEKHIYLMASGRINMCGLTTKNLDYVAKSIYEAVTKIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SLI8</accession>
    <name>A0A8C2SLI8_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Acyl-CoA thioesterase 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ACOT12</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>butanoyl-CoA + H2O = butanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40111"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17968"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57371"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:40112"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; fatty acid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015705253.1">
        <property type="nucleotide sequence ID" value="XM_015849767.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SLI8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005001114.1">
        <property type="protein sequence ID" value="ENSCJPP00005000619.1"/>
        <property type="gene ID" value="ENSCJPG00005000706.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107306526"/>
    <dbReference type="KEGG" id="cjo:107306526"/>
    <dbReference type="CTD" id="134526"/>
    <dbReference type="GeneTree" id="ENSGT00940000160328"/>
    <dbReference type="OrthoDB" id="3184331at2759"/>
    <dbReference type="UniPathway" id="UPA00199"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome Z"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045171">
        <property type="term" value="C:intercellular bridge"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003986">
        <property type="term" value="F:acetyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006084">
        <property type="term" value="P:acetyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03442">
        <property type="entry name" value="BFIT_BACH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000029">
        <property type="entry name" value="Acyl-CoA thioesterase 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000011">
        <property type="entry name" value="Acyl-coenzyme A thioesterase 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040170">
        <property type="entry name" value="Cytosol_ACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033120">
        <property type="entry name" value="HOTDOG_ACOT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11049:SF3">
        <property type="entry name" value="ACETYL-COENZYME A THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11049">
        <property type="entry name" value="ACYL COENZYME A THIOESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00234">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51770">
        <property type="entry name" value="HOTDOG_ACOT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="HotDog ACOT-type" evidence="11">
        <location>
            <begin position="7"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HotDog ACOT-type" evidence="11">
        <location>
            <begin position="182"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="START" evidence="10">
        <location>
            <begin position="367"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005000619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="554" mass="62154" checksum="68EB055714265BEB" modified="2022-01-19" version="1">MERSGAAGGWVPMCQSVLPAHANHRGELSAGQLLKWMDATACLAAEKHAGVSCVTASMDDIQFEEAARVGQVITIKARVNRAFKTSMEVGIKVTVQDVLTNVEKIVSVAYATYVVKPVGAEKIELEPVKLMSAEDYLEHALATERKRIRLGYQEVFQNLMQESNKEGDHYDTFEEENAVSTDLTHVQSIELVQPPHANHHGNTFGGQIMAWMETVASISASRLCRSYPILKSVNMFKFWGPSVVGDRLVFNAIVNNTFQNSVEVGVRVEAYNCEEWIRNQARHINSAFLIFNAMNDKGELLTFPKIKPITKDGVRRYHGAIARKRIRLARKYMLSAKEDKPYDLWEKSNEAYMSYSNIATLTYLAAKPGWEVTSTLNNIKIWTHEDGDVLSLKVEMQVKTASHVAFSLLSNFMYRQQWDKHFLTCEVLQAVSEDDIIYYVTAPPPPMTGLQPRDFVILVSRRQPLEPSEPYIVAVKSVTLTSKPPSSEHCRSEILCAGFQIYSDSSSSCRVHYFNQMTSGLMPYLAANLIGSSNSIEDAALECIKFLELKGSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SLJ3</accession>
    <name>A0A8C2SLJ3_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Cytochrome b-c1 complex subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">UQCRB</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with cytochrome c oxidase (complex IV, CIV).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the UQCRB/QCR7 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SLJ3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005001001.1">
        <property type="protein sequence ID" value="ENSCJPP00005000549.1"/>
        <property type="gene ID" value="ENSCJPG00005000646.1"/>
    </dbReference>
    <dbReference type="KEGG" id="cjo:107310358"/>
    <dbReference type="GeneTree" id="ENSGT00390000012916"/>
    <dbReference type="OrthoDB" id="425749at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1090.10:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1090.10">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003197">
        <property type="entry name" value="QCR7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036544">
        <property type="entry name" value="QCR7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12022:SF0">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12022">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX 14 KD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02271">
        <property type="entry name" value="UCR_14kD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000022">
        <property type="entry name" value="Bc1_14K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81524">
        <property type="entry name" value="14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR000022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005000549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="111" mass="13530" checksum="C64A4E5B87E89AC1" modified="2022-01-19" version="1">MAARATVSGGGRLMDRLRKWYYNAAGFNKYGLMRDDTLYEDEDVKEALKRLPEDLYNERMFRIKRALDLSLKHRILPKEQWVKYEEDKPYLEPYLKEVIRERLEREAWNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SMA0</accession>
    <name>A0A8C2SMA0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GPR158/179 extracellular domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SMA0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005001609.1">
        <property type="protein sequence ID" value="ENSCJPP00005000907.1"/>
        <property type="gene ID" value="ENSCJPG00005001001.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160776"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043458">
        <property type="entry name" value="GPR158/179"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054714">
        <property type="entry name" value="GPR158_179_extracellular"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32546">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 158-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32546:SF7">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 179-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22572">
        <property type="entry name" value="GPR158_179_EC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="GPR158/179 extracellular" evidence="10">
        <location>
            <begin position="235"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005000907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="386" mass="41359" checksum="A3A3D7ACC4366AFD" modified="2022-01-19" version="1">MSPSRSVPSLLLPAAPGPSAVAQALSRARQLRSPPVPSVPIPRYRPSAAALGAEQGSAALSFLRTGDVRSLALTNCSRSAALRPPAPDPPQTLRAALRAAPEALTQAANFLNMLLQGNDLRESSVAEDVEWYQALTRSLAGGHPWARRSLLALDAHPAAPSPRLVLQATAADGEIHLRDVSAPGNRSSDGEWVAELRERRGPPLRKRVLSNDLRSMETPKWLRGDGYVAGPGHVRWSQPFLECRDGKFVPVWAVALSAAFYGLKPDLSPEFNSEPGACSARDPRPPSPPQPHRAMLWVTPPHSSPFYPQYRLMVPLACRAAGAGRAVRAAGTMLRARCRRIVPFVLPCCAARRAACWPCSSACCSLITAGGARREQSGVPNIPPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SNQ1</accession>
    <name>A0A8C2SNQ1_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome c oxidase VIII family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SNQ1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005000634.1">
        <property type="protein sequence ID" value="ENSCJPP00005000332.1"/>
        <property type="gene ID" value="ENSCJPG00005000420.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00960000189643"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.81.10">
        <property type="entry name" value="Cytochrome c oxidase, subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003205">
        <property type="entry name" value="Cyt_c_oxidase_su8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036548">
        <property type="entry name" value="Cyt_c_oxidase_su8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16717">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE VIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16717:SF5">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 8, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02285">
        <property type="entry name" value="COX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81431">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit VIIIb (aka IX)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005000332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="115" mass="12430" checksum="6BB40535F35554FB" modified="2022-01-19" version="1">MGRSGVWVCRGCEGWVREGARVSRGAGSRAPVGVRVGPPHPASSFRALRRVGCCPSRRPPDPDSRVWSAPPLSLCERNGRAPIHSTVVGLAAMFVTCLGPAAWVLSHLEEYKKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SPB2</accession>
    <name>A0A8C2SPB2_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleoredoxin like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">NXNL1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015705948.1">
        <property type="nucleotide sequence ID" value="XM_015850462.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SPB2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005002973.1">
        <property type="protein sequence ID" value="ENSCJPP00005001769.1"/>
        <property type="gene ID" value="ENSCJPG00005001803.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107307018"/>
    <dbReference type="KEGG" id="cjo:107307018"/>
    <dbReference type="CTD" id="115861"/>
    <dbReference type="GeneTree" id="ENSGT00940000161246"/>
    <dbReference type="OrthoDB" id="189920at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048018">
        <property type="term" value="F:receptor ligand activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045494">
        <property type="term" value="P:photoreceptor cell maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd03008">
        <property type="entry name" value="TryX_like_RdCVF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029520">
        <property type="entry name" value="RdCVF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47109">
        <property type="entry name" value="NUCLEOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47109:SF1">
        <property type="entry name" value="NUCLEOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13905">
        <property type="entry name" value="Thioredoxin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="21"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005001769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="239" mass="27499" checksum="932C0912181BBC35" modified="2022-01-19" version="1">MNSSRERAGKGEGRLCGSSRPIWALTALHIPLMASLFAGKVLLVNNRDRDEVETERELCLVLENRVVLLYFGAAECPRCRRFVPRLKDFFVRLTDEFYVERASQLCLVYVSRDATAQQEEAFLKSMPKRWLSLPFGDEFKRELELRFEVSEVPRVVVLKPNGDVIVGNAVDEITRMGPACFQNWQEAAELVDRNFRLAEDFDDCARRSITDPLRRLKYKLGKGEESRSEEQKEEGDESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SPX2</accession>
    <name>A0A8C2SPX2_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mab-21 like 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">MAB21L4</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SPX2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005003465.1">
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        <property type="gene ID" value="ENSCJPG00005002089.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01050000244827"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046906">
        <property type="entry name" value="Mab-21_HhH/H2TH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024810">
        <property type="entry name" value="MAB21L/cGLR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10656">
        <property type="entry name" value="CELL FATE DETERMINING PROTEIN MAB21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10656:SF7">
        <property type="entry name" value="PROTEIN MAB-21-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20266">
        <property type="entry name" value="Mab-21_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01265">
        <property type="entry name" value="Mab-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mab-21-like HhH/H2TH-like" evidence="2">
        <location>
            <begin position="322"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005001979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="499" mass="55314" checksum="BA5BE1A0B4217A08" modified="2022-01-19" version="1">MPSALQCSRGDDGAAPSPGSALPLARPGSHPGATPQPGFPPPSSHSLPALPPTELCARSRAAPAMAAGGCRWRSCLEVVASRQGQRVQHFQQAEDILLTLLEHIHAEEPRFLVDYSRNLEAFEFVLCASEDAVVVEVPLRIDGDALRVRLCQAMDSGSTGHGQLGACSLEVPSAVTGVEDWSSTGTTDSMEQVRCLAPGKVLQHLKELLVSAIVQCQRRSLLQPGDLSAENLKEGATELPLLVRGGWRTIRFDVVPVVRRRQETPGLDGRQRDRGFPEGTLQKATADAHFVPASNHCWRPSTHLPILKLLWAVDTLQGPRLDSLRLLEQLRSQDWREEDGRDGLTFNHLKMVLLWSTELFPSPEDWQDLEGSVYRLLVVLLRCLATQCLPHFLHPEQNLFQGDPQHLASLYPKVEAFARDPARFLRFHFGLPTRADGVQADPALRALLQLPAKDGAHWDTAYFDVLLSQLQVYHIQDATRRSAMSWLLNKLRRDIPLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SQM3</accession>
    <name>A0A8C2SQM3_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Coiled-coil domain containing 125</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CCDC125</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015705275.1">
        <property type="nucleotide sequence ID" value="XM_015849789.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015705276.1">
        <property type="nucleotide sequence ID" value="XM_015849790.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SQM3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005001914.1">
        <property type="protein sequence ID" value="ENSCJPP00005001112.1"/>
        <property type="gene ID" value="ENSCJPG00005001183.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107306536"/>
    <dbReference type="KEGG" id="cjo:107306536"/>
    <dbReference type="CTD" id="202243"/>
    <dbReference type="GeneTree" id="ENSGT00440000039958"/>
    <dbReference type="OrthoDB" id="9939852at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome Z"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000146">
        <property type="term" value="P:negative regulation of cell motility"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:negative regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034608">
        <property type="entry name" value="CCDC125"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28616">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 125"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28616:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 125"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="49"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="90"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005001112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="507" mass="56750" checksum="010C4774D50E0CD4" modified="2022-01-19" version="1">MEEAEEDDMACGDLGNGLGRRPGGVYEGEKLQNYSFRSKKVSVKAHNTLSSIKGVEENDATPLPCSKRNSFHDGSPKKHLLSPARQSSCESTAEVSNEELKQQLQEALEEIELLKVELEAAQRKLEGKDEALRILQSMAVFSKATSHTKAMLEKTEEEKRTLEKEINILQWEIEFDQDRFKNIEDTWTEKYDRIYCENTALKEALKLRTEEVKTLKSENAILNQQHLEFLAMLDVNKQKIVQENMSIDRRDITDITGLELAVLGACTCSTSGGQPCSCARMAAVTRKQVLHLKQEMELLMKSKDEAYVMADAFRIAFEQQLMQRKDQALRLAEVIKIKKETKFINWRRLKEDGSVKLQGNKNSLGQKLSGLLSSDADSRKVEVLDNPHEILKMLIDLVNDKEEALAHQRKVSYMLARAMELKEAAQETQGRSPSGHGGKAVQSCVPAAVGRACCCDLASTSSLSSAPNGNGLQNSVRVLRKSHSWPSEAVCREESDPCGKAYETVVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SQN1</accession>
    <name>A0A8C2SQN1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kish</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">TMEM167A</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 9">Involved in the early part of the secretory pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the KISH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015705244.1">
        <property type="nucleotide sequence ID" value="XM_015849758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SQN1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005001073.1">
        <property type="protein sequence ID" value="ENSCJPP00005000591.1"/>
        <property type="gene ID" value="ENSCJPG00005000681.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107306520"/>
    <dbReference type="KEGG" id="cjo:107306520"/>
    <dbReference type="CTD" id="153339"/>
    <dbReference type="GeneTree" id="ENSGT00940000155186"/>
    <dbReference type="OrthoDB" id="10034655at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome Z"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045054">
        <property type="term" value="P:constitutive secretory pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051523">
        <property type="entry name" value="KISH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009653">
        <property type="entry name" value="Ksh1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13229">
        <property type="entry name" value="PROTEIN KISH-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06842">
        <property type="entry name" value="DUF1242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU910717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005000591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="89" mass="9885" checksum="164811989458D39B" modified="2022-01-19" version="1">MLKGRTDSSEDSYSVQLKSAIFNFQSILTVILLLICTCAYIRSVAPSLLDKNKTGLLGIFWKCARIGERKSPYVAVCCVVMAFSILFVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SRM0</accession>
    <name>A0A8C2SRM0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Delta-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">JAG2</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Putative Notch ligand involved in the mediation of Notch signaling.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Membrane</location>
            <topology evidence="1 15">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015721151.1">
        <property type="nucleotide sequence ID" value="XM_015865665.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005005100.1">
        <property type="protein sequence ID" value="ENSCJPP00005002765.1"/>
        <property type="gene ID" value="ENSCJPG00005003061.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107315355"/>
    <dbReference type="KEGG" id="cjo:107315355"/>
    <dbReference type="CTD" id="3714"/>
    <dbReference type="GeneTree" id="ENSGT00940000160944"/>
    <dbReference type="OrthoDB" id="283575at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005112">
        <property type="term" value="F:Notch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009912">
        <property type="term" value="P:auditory receptor cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990134">
        <property type="term" value="P:epithelial cell apoptotic process involved in palatal shelf morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042492">
        <property type="term" value="P:gamma-delta T cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016331">
        <property type="term" value="P:morphogenesis of embryonic epithelium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045747">
        <property type="term" value="P:positive regulation of Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030155">
        <property type="term" value="P:regulation of cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042127">
        <property type="term" value="P:regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003016">
        <property type="term" value="P:respiratory system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001501">
        <property type="term" value="P:skeletal system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045061">
        <property type="term" value="P:thymic T cell selection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000018">
        <property type="entry name" value="Delta-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000007">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000061">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000117">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000148">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000310">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000431">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000445">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000473">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000824">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.140:FF:000001">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.3510:FF:000006">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000095">
        <property type="entry name" value="Notch, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000143">
        <property type="entry name" value="Protein crumbs 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000146">
        <property type="entry name" value="Putative neurogenic locus notch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001774">
        <property type="entry name" value="DSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056986">
        <property type="entry name" value="JAG1_1/2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026219">
        <property type="entry name" value="Jagged/Serrate"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011651">
        <property type="entry name" value="Notch_ligand_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001007">
        <property type="entry name" value="VWF_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12916">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE VIC-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12916:SF12">
        <property type="entry name" value="DELTA-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01414">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21700">
        <property type="entry name" value="EGF_DL_JAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25024">
        <property type="entry name" value="EGF_TEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23575">
        <property type="entry name" value="JAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07657">
        <property type="entry name" value="MNNL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00010">
        <property type="entry name" value="EGFBLOOD"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02059">
        <property type="entry name" value="JAGGEDFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00051">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SMART" id="SM00215">
        <property type="entry name" value="VWC_out"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51051">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="2 15" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="11 13 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 13 15" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 15 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0677">Repeat</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="5 15 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1149"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="domain" description="DSL" evidence="19">
        <location>
            <begin position="258"/>
            <end position="302"/>
        </location>
    </feature>
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            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="409"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="447"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="485"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="523"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="560"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="598"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="663"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="702"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="740"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="778"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="817"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="855"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="893"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1180"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1237"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1180"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="1237"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1291"/>
            <end position="1304"/>
        </location>
    </feature>
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        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
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    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="273"/>
            <end position="285"/>
        </location>
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    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="293"/>
            <end position="302"/>
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            <begin position="397"/>
            <end position="406"/>
        </location>
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            <begin position="435"/>
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
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            <begin position="473"/>
            <end position="482"/>
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    <feature type="disulfide bond" evidence="13">
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            <begin position="511"/>
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
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            <begin position="527"/>
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            <end position="557"/>
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    <feature type="disulfide bond" evidence="13">
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        </location>
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    <feature type="disulfide bond" evidence="13">
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            <begin position="624"/>
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        </location>
    </feature>
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        <location>
            <begin position="919"/>
            <end position="928"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
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        </source>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023157"/>
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    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    <sequence length="1304" mass="143843" checksum="25C5768183C5629D" modified="2022-01-19" version="1">MGNEAVTPAPTCWPSAELRRIEGERSPREGSGGGGALRAAPPAAHALRPPRRPCRQLRARRAALRRPRGAAAMRPPAPLGPALLLLLLAASVQVSRGTGYFELQLNSVRNVNGELFNGECCDGTRNPTERDCGRDECDTYVKVCLKEYQAKISPGGPCSYGSGSTPVLGGNILYLNGDKYHPRGRSPETGRIVIPFQYAWPRSFTLILEAWDWDNDTKSGEDLLIERVAHAGMINPEDRWKTLQFNGPVANFEVQIRVKCDENYYSALCNKFCGPRDDFVGHYTCDQNGNKACMEGWMGEECKQAVCKQGCNLLHGGCSVPGECKCHYGWQGQYCDECVRYPGCAHGSCNEPWQCNCETNWGGLLCNKDLNYCGNHHPCLNGGTCMNTEPDEYRCACPDGYSGKNCEIAEHACVSNPCANGGTCHEISSSFKCHCPSGWSGPTCAIDIDECASNPCAQGGTCIDHINSFECICPQQWIGATCQLDANECEGKPCVNAYSCKNLIGGYYCDCIPGWKGVNCHININDCHGQCQHGGTCKDEVNDYHCICPRGFTGKNCEIETNECESNPCQNGGRCKDLVNGFACLCTQGFSGVFCEVDIDFCEPNPCQNGAKCYDLGGDYYCACPDDYDGKNCSHLKDHCKNNSCKVIDSCTIEVFSNTTQEGIRFISSNVCGPHGRCISQPGGNFTCACDRGFTGIYCHENINDCLGKPCKNGGTCIDEVDSFKCFCSSGWEGELCDTNFNDCSPNPCHNGGRCIDLVNDFYCECKNDWKGKTCHSREYQCDANTCSNGGTCYDDGDTFRCSCPPEWIGSTCNIAKNSSCLPNPCMNGGTCVGSGDSFSCICKEGWEGRTCTQNTNDCNPHPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCGYGATCIDEINGYRCTCPPGRVGPRCQEVIGIGKPCWLKGMTFPHGSRWDQECNSCHCLDGRIDCTKVWCGKKPCLLHKHWENSNYQCPMGQECQEKYMKCFQPPCTEWGECSASEPLPANIKCLPNSGYLDNDCARITLIFNGNKVPQGTTTENICSEIRYLPATRSVSRDRVLIILCDLSYSTENAVEVAISFVPHRDEQDNSLIQNAANIIVNAITKRQNSTVMLAVTEVKVETIVVGNSSSDYLVPILCAVFSVVWLTCIIICVWWTRKRRKERERSHPPREEGANNQWAPLNPIRNPIDRSYSNKDIRYECKNFISPQKRTCDAVEEYVEYEEEEDEEEERDEEMDKFLSHKLTKPLPTKASDASESSPVKKSLQIGKMDNRSVKNVNASNFESSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SRY2</accession>
    <name>A0A8C2SRY2_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Extracellular tyrosine-protein kinase PKDCC-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC107315363</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SRY2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005004253.1">
        <property type="protein sequence ID" value="ENSCJPP00005002367.1"/>
        <property type="gene ID" value="ENSCJPG00005002549.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000001205"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001501">
        <property type="term" value="P:skeletal system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022049">
        <property type="entry name" value="FAM69_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042983">
        <property type="entry name" value="PKDCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46448">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46448:SF2">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12260">
        <property type="entry name" value="PIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="152"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005002367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="528" mass="57706" checksum="CD19FEE98F22792B" modified="2022-01-19" version="1">MASLLIPSHCITPHSVVSRTISPLPFWEATPLRDTRRCRSRPGRRPPAPPGLSLPAPPLGSVHLPARRSSARRCPAPTMQAAGRLRAAVLSAALLALSALALLLLPALRAGSALPPGLLEELRQRRRDLRRLEAGGKAEEGGLSCGDVRRAAGTATVLGSGFTKVVVRAALEGGGAVALKSVHGAGREVRQCEQRYGAPDGCRRLAAYKLLKEVTLLRLLRHPGIVQLHGQCYDSGGEPEAGVTAVLELGAPLEMIQLLQTPWEERFKICLGLVELLFYLAHSPLGSIVLLDFQPRQFVMVDGNLKVTDMDDASTEELSCEEDNDCTLDFPTKSFPLQCSSAGKCEGINEKRNLFNAYRYFFTYLLPHSAPPALQPFLSDILNATGNLRYGINETLRAFEKVLHLYKSGLYLQKRPILLKDYIFLRGFRTEEAEAYKCWPSYSHLGCLLSVHSPEEAAAICSSQPQCQSFIITQQRTWTGELGMGLLSSCHVVPCCLGLCPPLWCCVTLGVYKCCLSYLDQKSSVMGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2ST22</accession>
    <name>A0A8C2ST22_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DnaJ homolog subfamily C member 22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">DNAJC22</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May function as a co-chaperone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2ST22"/>
    <dbReference type="Ensembl" id="ENSCJPT00005006007.1">
        <property type="protein sequence ID" value="ENSCJPP00005003380.1"/>
        <property type="gene ID" value="ENSCJPG00005003572.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000012136"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome LGE22C19W28_E50C23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007829">
        <property type="entry name" value="TM2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44733">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44733:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05154">
        <property type="entry name" value="TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="322"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005003380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="386" mass="41859" checksum="5C176B824C04E330" modified="2022-01-19" version="1">MGTGGPGWRVWDLDGHGLTLCGHTGLGSIWAQGFWGVGMEQFWAGWWVHMGHRGVCQCPPTPSHVPSHRTPDARATPEPHCEPASMAKRLLVAYGLWALGGPLGLHHLYLGRDSHALLWMLTLGGFGAGWLSDLWNLHRWVATANSTGRQHRGAVPALSPIRLVGQVVVGIYFGLMAALALPWVPQLLAQPLAVGLGVLLTASVGQQSTKAHRVLTAAFLTSLLFQAQLLAVLPSSLAAGMAAQRHRRHQHPIEPPLRLRARLFRLGMAYMAFAIPVGYSLLHSTAGVLGWVGAIPMRSFQSLAWLLGLKAGTGGCTERQLWASQVLGVPPCSGIEEVQRSYRELVKLWHPDHNMQRAEEAEQRFIELQEAYEVLGGPRRAAAGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2STT8</accession>
    <name>A0A8C2STT8_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mastermind-like protein 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2STT8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005006498.1">
        <property type="protein sequence ID" value="ENSCJPP00005003706.1"/>
        <property type="gene ID" value="ENSCJPG00005003848.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183201"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007221">
        <property type="term" value="P:positive regulation of transcription of Notch receptor target"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046369">
        <property type="entry name" value="MAML1-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15692">
        <property type="entry name" value="MASTERMIND-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15692:SF9">
        <property type="entry name" value="MASTERMIND-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005003706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="357" mass="38409" checksum="EC8BBE117DAC51CB" modified="2022-01-19" version="1">MHVFSFPGGSPAVSMSSSMSLSNPISTHSIMPQSSSLMSTPAGTRMPSVPAARSMSCYGNLPCNQPSAYSVTSGMNQMQPHRNQNQVLPTQNNPMMSRQQSMTQNNNTAAFGTGSVVSSQQVRPSLNHGATGIPVQRPPNVMITATATAQNWAPQEAAVKQQDALKPTGVRFPTSTPYSNQSLQRNMGNQHFPQRALAPPNQLTAGVQMRPPLNQMHQTVNGQSAGSLRGLSVRPNQIRGQTVPTLNQPGTSMTPPSSLPSTSFTSTNQNSRAYQGGDHGSDLTFDFLNQQSDSIGPALNSDSDFIDSLLKTEPGNDDWMKDINLDEILGNHSACSQYQRKPPSCQQHIWSIEGDMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SUL9</accession>
    <name>A0A8C2SUL9_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MAM and LDL receptor class A domain containing 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MALRD1</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSCJPT00005006932.1">
        <property type="protein sequence ID" value="ENSCJPP00005004054.1"/>
        <property type="gene ID" value="ENSCJPG00005004109.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158809"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042632">
        <property type="term" value="P:cholesterol homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070858">
        <property type="term" value="P:negative regulation of bile acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="CDD" id="cd06263">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000182">
        <property type="entry name" value="MAM and LDL-receptor class A domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000998">
        <property type="entry name" value="MAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051560">
        <property type="entry name" value="MAM_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23282">
        <property type="entry name" value="APICAL ENDOSOMAL GLYCOPROTEIN PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23282:SF140">
        <property type="entry name" value="MAM AND LDL-RECEPTOR CLASS A DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00629">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00137">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50060">
        <property type="entry name" value="MAM_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034449150" evidence="6">
        <location>
            <begin position="17"/>
            <end position="2122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="2037"/>
            <end position="2058"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="8">
        <location>
            <begin position="58"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="8">
        <location>
            <begin position="219"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="8">
        <location>
            <begin position="422"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="8">
        <location>
            <begin position="602"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="8">
        <location>
            <begin position="813"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="8">
        <location>
            <begin position="1038"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="8">
        <location>
            <begin position="1258"/>
            <end position="1420"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="8">
        <location>
            <begin position="1474"/>
            <end position="1634"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="8">
        <location>
            <begin position="1685"/>
            <end position="1850"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="1985"/>
            <end position="2019"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="794"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="1020"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="1217"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="1224"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="1438"/>
            <end position="1450"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="1445"/>
            <end position="1463"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="1457"/>
            <end position="1472"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="1650"/>
            <end position="1668"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="1662"/>
            <end position="1677"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="1881"/>
            <end position="1896"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="1909"/>
            <end position="1921"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="1916"/>
            <end position="1934"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="1928"/>
            <end position="1943"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="2009"/>
            <end position="2018"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005004054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="2122" mass="236237" checksum="AE41C337F523C6B9" modified="2022-01-19" version="1">MNKSICLCVLYCIALADICSPAGREWQHGDGSSAPAGELCVFTNQCGSRSDKRQGSFEKCDFETDLCKHLQVVNLNPGWIRRNGNSGVGPPYSDHNGNDSTYFLSLSSEMRLSSATLRSNVLLPTDEEHVCQITFQYWISQSGVLIVELQKHSEDTIKNIWHDAGELESQWKAKTITVNSSENFEVIFHGMVENQRQNETVAIDDVSFSEGCSLASVLQTSNFELGMCEWNSNQPVVPAWWAQLQSGHKITSCSSVKDHSNDTKGHLVCLEANDSALYRSAYLNSSMCHCSSKSCHFQFQYSMADSSVIKAVLYTNQEEHVLWETNTTTNKEWAKACMQIPTGLEKIKLKLKGTFQSKTGFICLNNIQFLDTTCSELSAFNSLEEFMCTNGKSTEHGSSCVFHPDCSDNSDEDPAACSANYSICNFDTDFCGWKTLNTTDTKWNIMKEGASFDSRLPDRDQTTKSGHETFIYFSGSSQMHKETAMSDLGSPFLVKLSPGYSCCQVRFWYWLSQDSQLSVFRRTALTGSLEKMCSISGLPEMEWTKASIPVESAAGDLPFQIIFQATTLAENATVAIDNISITKECEVVNISPSAIKSENKVSVCDFESDSCGWSEAANADGFDWIRSSSSTLEPAFQRQAPPQDHTYNKAEGHFMFILKNSSSISQVAQLRSPEFGQTGSNCTMSFWYYNYGQSVGAAEMQLLVDGLDEPTVLWRVYYNQGNQWLKSVIQLGRLSHPFQFSLIKISLGFYDGVSAIDDITFENCALPPPASSCEGPNRFWCRDTKACISRLLVCDLVDDCGDGSDEDKCNPDLQCDFENGLCNWVQDTEDDFDWIRIQGPTPTVNTGPLKDHTTGTSLGHYLYMESSEPQEFGDKAVLLSPLFSPTYNRTCIFRFHYHMSGKQVYTLSVFQRTMSNMKGTLLWYKYGNQGGRWIRHTLYISSSKPFQILVKGTVGDGFTGDIGLDDLSFLDCALYNGSLPTISTTLSGTSSPITLPFNNCTENEFVCRDSGHCIHMNQKCNFRPDCSDNSDESDCAKEICSFEDNTQCGWYQPALEEIQDTDSIAKMFKWELGSGAKLYPGEEEHCPSTDHTTNTEEGVYLFADSSNGEYGQIADIATPAISFTGPHCKITFWNHMNGSTVGSLEVLCKTGNKTSTLWTQSGSQGPKWNRAEVFLGIRSDFQIIFRAKCGVSYMGDVAVDDITFEDCSPLLIPDRPCTLEEFTCANKYCIPKDKLCDFVNDCADNSDENPAICRTSIGRCDFEFDLCDWKQEENDDFDWHLRTSSASKLGSGPAADHTLQELSGHYIFIKSSFLQLPGQKARISSPVLSRMNKNCKIFFYYHMYGAHIGSLIVYQMTMSKHEKILLILTGNQGNFWQSKALNLVGDGNEDFQVIFEGIVGRGLKHGIALDDITLSRECLRSQEFLPAESTTEPSTGSCSHGYWQCQNGKCYRPEQSCDFEDNCGDNTDESECGTSCTFENGRCGWQNSLADSFDWVLGAGSPQSLRPPRDHTLGNRTGQFLYLEATAIGLKNQKAHVRSSRWKESSRSCVLSFWYFKSSKATGCIQVLIKAMYKTDDGIIKMWSDSGSVSEEWRKVELHLGKLRNFEVIFEGIRTRDLGGGAALDDIEFNNCSTAGENPRECPAFTDFVCLNEDCIESQLVCDYKPDCEDLSDETDCSYYTSIPGSCNFETQEQEWTTVCGLTQDPWDDFDWTIGSGGVTGQMSPDTDHTPGKGKHFLYVNSTAQEEGSRARIITTEFFPASLGVCRVRFWFWMFPSRQTGVLKVYSVEEHGMDILMWSSSKNEENKWMYANVVLSSNAPFRVAFEVEVGQREPTEFALDDISFTPECMDGGPAKPQPPTCSSDQFPCVYMQQCLPLNAKCNGVEECLDGTDEMNCPSVTPTTVSPSSCKPTEFLCPSKGCIPALLKCDGVPDCPLNEDEIGCSITDCFNGSLLCVSTNQCIAVSQRCNGIADCIDFSLDESSCSVCPDEYCKNGGTCIIKDDIPLCQCGKEWKGNRCHISAKPLQSPISSLLQNDIWIGLGISFLLIKISVAALCFLSKKKEHKMKAEENINTSFANPLYEDLSSSGKAKSPGYTTSPVVQISVSPWHEYPFNEERNTRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SUU0</accession>
    <name>A0A8C2SUU0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sorting nexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">SNX5</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in several stages of intracellular trafficking.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015712603.1">
        <property type="nucleotide sequence ID" value="XM_015857117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SUU0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005006955.1">
        <property type="protein sequence ID" value="ENSCJPP00005004076.1"/>
        <property type="gene ID" value="ENSCJPG00005004126.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107310971"/>
    <dbReference type="KEGG" id="cjo:107310971"/>
    <dbReference type="CTD" id="27131"/>
    <dbReference type="GeneTree" id="ENSGT00940000154632"/>
    <dbReference type="OrthoDB" id="9976382at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098559">
        <property type="term" value="C:cytoplasmic side of early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070685">
        <property type="term" value="C:macropinocytic cup"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097422">
        <property type="term" value="C:tubular endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034452">
        <property type="term" value="F:dynactin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006907">
        <property type="term" value="P:pinocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046628">
        <property type="term" value="P:positive regulation of insulin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd07663">
        <property type="entry name" value="BAR_SNX5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000008">
        <property type="entry name" value="Sorting nexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000001">
        <property type="entry name" value="Sorting nexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028654">
        <property type="entry name" value="BAR_SNX5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014637">
        <property type="entry name" value="SNX5/SNX6/SNX32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45850">
        <property type="entry name" value="SORTING NEXIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45850:SF5">
        <property type="entry name" value="SORTING NEXIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036924">
        <property type="entry name" value="Snx5_Snx6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="5">
        <location>
            <begin position="37"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR036924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005004076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="415" mass="47638" checksum="4F2E51EF39F527AC" modified="2022-01-19" version="1">MRGGGGREAAGGGWRYRDMALLRDGAKNKLRSVSVDLNVDPSLQIDIPDALSEKDRVKFTVHTKTTLPAFQSPEFSVTRQHEDFVWLHDTLSETEEYAGLIIPPAPSKPDFDGPREKMQKLGEGEVSMTKEEFAKMKQELEAEYLAVFKKTVSSHEIFLQRISSHPVLSKDHNFCVFLEYDQDLSVRRKNTKEMLGFLLKSVVKSADEILLSGVKEVDDFFEQEKTFLVNYHNRIKDACAKADKMTRSRKNVADDYIYTSACLNSLALEEPTVIKKYLLKVAELFEKLRKVESRISSDEDLKLSELLRYYMLNIDAAKDLLYRRARALVGYENSNKALDKARLKSKDVNLAEAHQQDCYQKFEKISESAKQELISFKQKRIIAFRKNLIEMAELEIKHAKNNVSLLQSCIDLFKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SW89</accession>
    <name>A0A8C2SW89_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="26">Solute carrier family 22 member 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="27">Organic cation transporter 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="30" type="primary">SLC22A3</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="30" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="30" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="30" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(R)-adrenaline(out) = (R)-adrenaline(in)</text>
            <dbReference type="Rhea" id="RHEA:73875"/>
            <dbReference type="ChEBI" id="CHEBI:71406"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>(R)-noradrenaline(out) = (R)-noradrenaline(in)</text>
            <dbReference type="Rhea" id="RHEA:73871"/>
            <dbReference type="ChEBI" id="CHEBI:72587"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>(R)-salsolinol(in) = (R)-salsolinol(out)</text>
            <dbReference type="Rhea" id="RHEA:74791"/>
            <dbReference type="ChEBI" id="CHEBI:194082"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-histidyl-L-proline diketopiperazine(in) = L-histidyl-L-proline diketopiperazine(out)</text>
            <dbReference type="Rhea" id="RHEA:74787"/>
            <dbReference type="ChEBI" id="CHEBI:90039"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>agmatine(out) = agmatine(in)</text>
            <dbReference type="Rhea" id="RHEA:72131"/>
            <dbReference type="ChEBI" id="CHEBI:58145"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>dopamine(out) = dopamine(in)</text>
            <dbReference type="Rhea" id="RHEA:73863"/>
            <dbReference type="ChEBI" id="CHEBI:59905"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>guanidine(out) = guanidine(in)</text>
            <dbReference type="Rhea" id="RHEA:73883"/>
            <dbReference type="ChEBI" id="CHEBI:30087"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>histamine(out) = histamine(in)</text>
            <dbReference type="Rhea" id="RHEA:73879"/>
            <dbReference type="ChEBI" id="CHEBI:58432"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>serotonin(out) = serotonin(in)</text>
            <dbReference type="Rhea" id="RHEA:73867"/>
            <dbReference type="ChEBI" id="CHEBI:350546"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>spermidine(in) = spermidine(out)</text>
            <dbReference type="Rhea" id="RHEA:35039"/>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>tyramine(in) = tyramine(out)</text>
            <dbReference type="Rhea" id="RHEA:74783"/>
            <dbReference type="ChEBI" id="CHEBI:327995"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Apical cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Basolateral cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015713549.1">
        <property type="nucleotide sequence ID" value="XM_015858063.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SW89"/>
    <dbReference type="Ensembl" id="ENSCJPT00005007615.1">
        <property type="protein sequence ID" value="ENSCJPP00005004574.1"/>
        <property type="gene ID" value="ENSCJPG00005004486.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107311525"/>
    <dbReference type="KEGG" id="cjo:107311525"/>
    <dbReference type="CTD" id="6581"/>
    <dbReference type="GeneTree" id="ENSGT00940000160810"/>
    <dbReference type="OrthoDB" id="5141738at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005640">
        <property type="term" value="C:nuclear outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008504">
        <property type="term" value="F:monoamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005326">
        <property type="term" value="F:neurotransmitter transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015651">
        <property type="term" value="F:quaternary ammonium group transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019534">
        <property type="term" value="F:toxin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990748">
        <property type="term" value="P:cellular detoxification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090494">
        <property type="term" value="P:dopamine uptake"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048241">
        <property type="term" value="P:epinephrine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051625">
        <property type="term" value="P:epinephrine uptake"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051615">
        <property type="term" value="P:histamine uptake"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015718">
        <property type="term" value="P:monocarboxylic acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051620">
        <property type="term" value="P:norepinephrine uptake"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032098">
        <property type="term" value="P:regulation of appetite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051610">
        <property type="term" value="P:serotonin uptake"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042908">
        <property type="term" value="P:xenobiotic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd17379">
        <property type="entry name" value="MFS_SLC22A1_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000165">
        <property type="entry name" value="Solute carrier family 22 member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004749">
        <property type="entry name" value="Orgcat_transp/SVOP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00898">
        <property type="entry name" value="2A0119"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 28" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 28" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 28" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="427"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="462"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="488"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="29">
        <location>
            <begin position="110"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00035884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00035897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00035901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00036470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00036483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00036490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00036661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00036754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00036845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00036998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00037001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00072456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00079877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005004574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="549" mass="61006" checksum="8ABBF2D33456D656" modified="2022-01-19" version="1">MPSFDEVLKEAGEFGRFQKRVFFLLCQTGITFSFLFASVVFLGTVPDNYWCRIPGAADLSEKCGWTLEEEQNFTVLPLLLVNGSSGGHCERLDVTWDAATGCASPLTHHLDGRVGSPPLITCQDSWVYRQPHASIVSEYNLVCGRAWMLDLSQAILNLGFLAGAFTLGYAADRYGRILIYLLSCLGVGICGVIVAFAPNFTLFLIFRFLQGVFGKGTWMTCYVIVTEIVGSDQRFVGIAIQIFFTLGIIILPGIAYLVPTWQGIQLAISLPNFLFLLYYWVVPESPRWLLTRKEGEKALKIMHDIAKHNGKYLSPHYSEITVSNMEVTNPSFLDLVKTPWMRRNTLILMYAWFTSALIYQGLVMRLGIVGGNLYLDFFISGAVELPAALIILITIDRIGRRLPFAISNIVAGIACLITAFLPEDIPWFKTTVATLGRLGITIAFEIVYLVNSELYPTTLRNFGVSLCSSLCDLGGIIAPFLLFRLAAIWLELPLIIFSVLAAVCGILVLLLPETKGIPLPETVEDVEQLSGHYCKCGKKRKHQNTNSYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SWE1</accession>
    <name>A0A8C2SWE1_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Nebulette</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">NEBL</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SWE1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005006903.1">
        <property type="protein sequence ID" value="ENSCJPP00005004026.1"/>
        <property type="gene ID" value="ENSCJPG00005004092.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154775"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09447">
        <property type="entry name" value="LIM_LASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000087">
        <property type="entry name" value="LIM zinc-binding domain-containing Nebulette"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051759">
        <property type="entry name" value="LIM-SH3_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000900">
        <property type="entry name" value="Nebulin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46218">
        <property type="entry name" value="LASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46218:SF3">
        <property type="entry name" value="NEBULETTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00880">
        <property type="entry name" value="Nebulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00227">
        <property type="entry name" value="NEBU"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51216">
        <property type="entry name" value="NEBULIN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="9">
        <location>
            <begin position="3"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="8">
        <location>
            <begin position="213"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005004026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="345" mass="39554" checksum="0228EE0BE794D930" modified="2022-01-19" version="1">MNPQCARCGKVVYPTEKVNCLDKYWHKGCFHCEVCKMALNMNNYKGYEKKPYCNAHYPKQSFTTVADTPENLRLKQQSELQSQVKYKRDFEESKGRGFSIVTDTPELQRLKRTQEQISNVKYHEDFEKTKGRGFTPVVDDPITERVRKNTQVVSDAAYKGVHPHIVEMDRRPGIIVAPVLPGAYQQSQSQGYGYMHQTSMSSMRSVHSQPHPAGLRTYRAMYDYSAQDEDEVSFRDGDYIINVQPIDDGWMYGYYQRICHVSSCCSADVWMRIAHFVSLGGKWKLWSTALVLMAKTSETYHQVNLGRMAVEGGFIYMANKVKKGQDVRSTFSTVQGLYLCRLSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SWS9</accession>
    <name>A0A8C2SWS9_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ammonium transporter AmtB-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SWS9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005006305.1">
        <property type="protein sequence ID" value="ENSCJPP00005003585.1"/>
        <property type="gene ID" value="ENSCJPG00005003720.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182844"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097272">
        <property type="term" value="P:ammonium homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002229">
        <property type="entry name" value="RhesusRHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11730">
        <property type="entry name" value="AMMONIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11730:SF48">
        <property type="entry name" value="AMMONIUM TRANSPORTER AMTB-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00342">
        <property type="entry name" value="RHESUSRHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="7">
        <location>
            <begin position="24"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005003585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="432" mass="45703" checksum="CDD5E7F5E14A02E4" modified="2022-01-19" version="1">MALPPPSSTRCLLPLSLGLFQAALLLFFALFITYDQHSAAPTNSEDTEHAAKQLHSTFPFFQDIQVMLVVGLGLLLAFLPRYGLSALTHNFLLLNVSAQWALMLQGLLDRLHHGKALLGLHSMLSAEFAAVTVLISAGAMLGRTSPSQLLAMALCEVPIYLASEWLIVTRLGVLDVGGTITIHVFACYFGLGVSKALFGNTKPTVHPKETPTPRSDLMALLGALILWVFWPSFVAVLCQPGDAQHRAILHTLLALSASSITTVLISILLEHDGKLSAAHLQNGSLAGGVAIGAVADMHITPAAALALGSLSSLLCILGFQFLTPLLAKKLSLQDRCGIHNLHGLPGILGAVASIVAALVAPKDSSEAARHWQAQWQAAGLVVALGGSLLSGLLVGAALRLPCLAPPPEPLCFEDALYFKFRVVSLMLSLCII</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SXG0</accession>
    <name>A0A8C2SXG0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TENT5A</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>RNA(n) + ATP = RNA(n)-3'-adenine ribonucleotide + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11332"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17347"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="ChEBI" id="CHEBI:173115"/>
            <dbReference type="EC" id="2.7.7.19"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:11333"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TENT family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="2"/>
    <dbReference type="RefSeq" id="XP_015714496.1">
        <property type="nucleotide sequence ID" value="XM_015859010.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SXG0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005007345.1">
        <property type="protein sequence ID" value="ENSCJPP00005004402.1"/>
        <property type="gene ID" value="ENSCJPG00005004348.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107312004"/>
    <dbReference type="KEGG" id="cjo:107312004"/>
    <dbReference type="CTD" id="55603"/>
    <dbReference type="GeneTree" id="ENSGT00940000157191"/>
    <dbReference type="OrthoDB" id="10065073at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048255">
        <property type="term" value="P:mRNA stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030501">
        <property type="term" value="P:positive regulation of bone mineralization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045669">
        <property type="term" value="P:positive regulation of osteoblast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009617">
        <property type="term" value="P:response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012937">
        <property type="entry name" value="TET5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12974">
        <property type="entry name" value="PRION-LIKE- Q/N-RICH -DOMAIN-BEARING PROTEIN PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12974:SF25">
        <property type="entry name" value="TERMINAL NUCLEOTIDYLTRANSFERASE 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07984">
        <property type="entry name" value="NTP_transf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01153">
        <property type="entry name" value="DUF1693"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005004402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="423" mass="47997" checksum="1E56CD8F078B94FF" modified="2022-01-19" version="1">MERAEERQRGAAAGPGSPRRPRTMADDEKAGGGYAGGCESAHCNVLSWEQVQRLDRILSETIPIHGRGNFPTLAMQPRQIVKVVRSRLEEKGIGLRDVRLNGSAASHVLHQDSGLGYKDLDLIFCADLKGEAEFQTVKDVVLDCLLDFLPEGVNKEKITPLTLKEAYVQKMVKVCNDSDRWSLISLSNNSGKNVELKFVDSLRRQFEFSVDSFQIKLDSLLLFYECSENPMTETFHPTIIGESVYGDFQEAFDHLCNKIIATRNPEEIRGGGLLKYCNLLVRGFRAASESEIKSLQRYMCSRFFIDFSDIGEQQRKLESYLQNHFVGLEDRKYDYLMTLHGVVNESTVCLMGHERRQTLNLITMLAIRVLAEQNIIPNVTNVTCYYQPAPYVADANFSNYYIAQVQTVFPCQQHTYSTWLPCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SXN7</accession>
    <name>A0A8C2SXN7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">2-oxoadipate dehydrogenase complex component E1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">2-oxoadipate dehydrogenase, mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Alpha-ketoadipate dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Dehydrogenase E1 and transketolase domain-containing protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">DHTKD1</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">2-oxoadipate dehydrogenase (E1a) component of the 2-oxoadipate dehydrogenase complex (OADHC). Participates in the first step, rate limiting for the overall conversion of 2-oxoadipate (alpha-ketoadipate) to glutaryl-CoA and CO(2) catalyzed by the whole OADHC. Catalyzes the irreversible decarboxylation of 2-oxoadipate via the thiamine diphosphate (ThDP) cofactor and subsequent transfer of the decarboxylated acyl intermediate on an oxidized dihydrolipoyl group that is covalently amidated to the E2 enzyme (dihydrolipoyllysine-residue succinyltransferase or DLST). Can catalyze the decarboxylation of 2-oxoglutarate in vitro, but at a much lower rate than 2-oxoadipate. Responsible for the last step of L-lysine, L-hydroxylysine and L-tryptophan catabolism with the common product being 2-oxoadipate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 2-oxoadipate + H(+) = N(6)-[(R)-S(8)-glutaryldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:69576"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:20093"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57499"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:184385"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:69577"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alpha-ketoglutarate dehydrogenase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SXN7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005007559.1">
        <property type="protein sequence ID" value="ENSCJPP00005004522.1"/>
        <property type="gene ID" value="ENSCJPG00005004273.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183125"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160167">
        <property type="term" value="C:oxoadipate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160166">
        <property type="term" value="F:2-oxoadipate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006091">
        <property type="term" value="P:generation of precursor metabolites and energy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002244">
        <property type="term" value="P:hematopoietic progenitor cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd02016">
        <property type="entry name" value="TPP_E1_OGDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1150:FF:000005">
        <property type="entry name" value="probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11610:FF:000005">
        <property type="entry name" value="Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11610">
        <property type="entry name" value="Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1150">
        <property type="entry name" value="TPP helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011603">
        <property type="entry name" value="2oxoglutarate_DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042179">
        <property type="entry name" value="KGD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031717">
        <property type="entry name" value="ODO-1/KGD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00239">
        <property type="entry name" value="2oxo_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006914">
        <property type="entry name" value="PRK09404.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152:SF4">
        <property type="entry name" value="2-OXOADIPATE DEHYDROGENASE COMPLEX COMPONENT E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152">
        <property type="entry name" value="2-OXOGLUTARATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16870">
        <property type="entry name" value="OxoGdeHyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000157">
        <property type="entry name" value="Oxoglu_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="13">
        <location>
            <begin position="556"/>
            <end position="759"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005004522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="906" mass="101670" checksum="FE9F2BDFEF816454" modified="2022-01-19" version="1">GAAMAASTARCALWRWSWRAGSRRWYRTERGVYGYKPRKAAGEGWRSRVELGERQIDHALARLITAYSEHGHKAAKINPLFAGQAVMNVVPEIQELAEVLQGPLITTGLLNMGKEEASVEDVLAYLDHVYCGHISIETSQLPTLEERQWFTKRFEELKQEAFTTEEKKHLCKLMLESQEFDRFLATKFSTVKRYGGEGAESMMGFFHELFKMCAYSGVTDIILGMPHRGRLNLLTGLLQLPPELMFRKMRGLSEFPENSAAIGMFLSHLTSSVDLDFEAINPVAVGKTRGRQQSLLDGDYSPESSAQPGDKVICLQVHGDGAFSGQGIVPETLTLSGLPHFRVGGSIHLIVNNQLGYTTPPERGRSSLYCSDIGKIVGCAVIHVNGDDPEEVLRATRLAVEYQRQFRRDVIVDLLCYRQWGHNELDEPFFTNPSMYKIIRSRKSIPDTYAEHLVATGLMTDVEVSEIKTTYYSKLNDHLANMTLYSPPPTNLQAHWKGLVEPSAKITTWDTGMPIPLLQFIGVKSVEVPEELQMHSHLLKTYAQSRVQKMEEGNKLDWATAETLAFGSLLSQGFNIRLSGQDVGRGTFSQRHAMLVCQETDDTYIPLNHMSPDQKGFLEVSNSPLSEEAVLGFEYGMSIESPKLLPIWEAQFGDFFNGAQIIFDTFISGGEAKWLLQSGIVILLPHGYDGAGPEHSSCRMERFLQMCDSSEEGVDGDRVNMSIVHPTTPAQYFHLLRRQMVRNFRKPLIVASPKVLLRLPAAVSSFEEMAPRTTFKPVIGDSSVEPKSVTHVVFCSGKHYYALVKQRETLGEKQHNTAIIRLEELCPFPLEALQQELSKYSHAKVFIWSQEEPQNMGPWSFVSPRFEKQLGVKLRLVSRPPLPAPAVGIGTLHQQQQEDILTSTFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SZU2</accession>
    <name>A0A8C2SZU2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Nicotinamide-nucleotide adenylyltransferase</fullName>
            <ecNumber evidence="20">2.7.7.1</ecNumber>
            <ecNumber evidence="20">2.7.7.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">NMNAT3</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>beta-nicotinamide D-ribonucleotide + ATP + H(+) = diphosphate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:21360"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="EC" id="2.7.7.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:21361"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="18">
            <dbReference type="Rhea" id="RHEA:21362"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>nicotinate beta-D-ribonucleotide + ATP + H(+) = deamido-NAD(+) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22860"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="EC" id="2.7.7.18"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:22861"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="17">
            <dbReference type="Rhea" id="RHEA:22862"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 20">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from nicotinamide D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="19">Homohexamer. Interacts with ADPRT/PARP1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 20">Belongs to the eukaryotic NMN adenylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.1" evidence="20"/>
    <dbReference type="EC" id="2.7.7.18" evidence="20"/>
    <dbReference type="RefSeq" id="XP_015726782.1">
        <property type="nucleotide sequence ID" value="XM_015871296.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015726784.1">
        <property type="nucleotide sequence ID" value="XM_015871298.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015726785.1">
        <property type="nucleotide sequence ID" value="XM_015871299.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032302472.1">
        <property type="nucleotide sequence ID" value="XM_032446581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SZU2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005009595.1">
        <property type="protein sequence ID" value="ENSCJPP00005006044.1"/>
        <property type="gene ID" value="ENSCJPG00005005694.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107317993"/>
    <dbReference type="KEGG" id="cjo:107317993"/>
    <dbReference type="CTD" id="349565"/>
    <dbReference type="GeneTree" id="ENSGT00950000183179"/>
    <dbReference type="OrthoDB" id="422187at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000309">
        <property type="term" value="F:nicotinamide-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004515">
        <property type="term" value="F:nicotinate-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034355">
        <property type="term" value="P:NAD+ biosynthetic process via the salvage pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006769">
        <property type="term" value="P:nicotinamide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009611">
        <property type="term" value="P:response to wounding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd09286">
        <property type="entry name" value="NMNAT_Eukarya"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000101">
        <property type="entry name" value="Nicotinamide-nucleotide adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051182">
        <property type="entry name" value="Euk_NMN_adenylyltrnsfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005248">
        <property type="entry name" value="NadD/NMNAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045094">
        <property type="entry name" value="NMNAT_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00482">
        <property type="entry name" value="nicotinate (nicotinamide) nucleotide adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12039">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12039:SF7">
        <property type="entry name" value="NICOTINAMIDE_NICOTINIC ACID MONONUCLEOTIDE ADENYLYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 20" id="KW-0520">NAD</keyword>
    <keyword evidence="11 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 20" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8 20" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="21">
        <location>
            <begin position="12"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00007064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00064648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU362021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="275" mass="31917" checksum="2DA5EB1CEFF99FB6" modified="2022-01-19" version="1">MSVKSRIPLILLACGSFNPITNMHMRLFELARDHLHQTGRYQVIEGIMSPVSDDYRKKGLVSAKHRIAMAKLALETSDWIRVDPWETEQESWTETIKVLRHHYNESVRLLQSRKECMKNKQFTERSTDNSVSSQSSVLPEVKLLCGADFLQTFQTPNLWKKEHIQEIVEQFGLVCISLAGSDPVQYINESELLTKFQHNIFLVKEWIQNEISSTQIRYALCRGLSVKYLIPDSVIDYIAYHNIYTEESERKNEGELLQPQKLYKAAVRLLNDKCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T033</accession>
    <name>A0A8C2T033_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Family with sequence similarity 53 member A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FAM53A</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM53 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T033"/>
    <dbReference type="Ensembl" id="ENSCJPT00005008081.1">
        <property type="protein sequence ID" value="ENSCJPP00005004920.1"/>
        <property type="gene ID" value="ENSCJPG00005004768.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063371"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029356">
        <property type="entry name" value="FAM53"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28567:SF2">
        <property type="entry name" value="PROTEIN FAM53A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28567">
        <property type="entry name" value="PROTEIN FAM53A-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15242">
        <property type="entry name" value="FAM53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="198"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="205"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="248"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005004920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="476" mass="52436" checksum="E88D1C22EDD07E77" modified="2022-01-19" version="1">MVTLITEKLQNQSLDDLTCKTYNINLYSSEKLNKSGSLFSFEINEDSPWKALNGGCPIQTDARNSAYPFPVCPFSTGPASNGALQWQQEPSSTSMVSGWISELNLNENSGQPLAPPTKRHCRSLSEPDELARCRSPWKPGNSKVWTPVSKRRCNSGGSATLQRCNSHGSATLQRSTSISLPQNILSLNNVFTVTSFNTSPVPRPSSASSGFVDSSEGSTSSSTRWNSGGPCDFNPRRRLSLSQEHITETGNLLPSANSTPTSTPELSRRQGLLRCRSQPCVLNEKKSRLKRRREEDVRWNRPSLDFFKMTRTLKNSKSLCSLDYEDDDDDTQMKTIVSSPCDSNDLMNIITPGSSPMKEQLDEVKSSIITGLERRPETDTGKGTSLKLQEGDPWLSVKDGCELASSQNVLVKVGENQSVGAPLPLKPPLCEQELELSCKESIYVTKRCDDKHLGILQGCNVKKFKIFGSGNNLGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T1C6</accession>
    <name>A0A8C2T1C6_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Envelope glycoprotein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T1C6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005010819.1">
        <property type="protein sequence ID" value="ENSCJPP00005006953.1"/>
        <property type="gene ID" value="ENSCJPG00005006422.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000165291"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018154">
        <property type="entry name" value="TLV/ENV_coat_polyprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10424:SF73">
        <property type="entry name" value="ENDOGENOUS RETROVIRUS GROUP FC1 ENV POLYPROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10424">
        <property type="entry name" value="VIRAL ENVELOPE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00429">
        <property type="entry name" value="TLV_coat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58069">
        <property type="entry name" value="Virus ectodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034821346" description="Envelope glycoprotein" evidence="3">
        <location>
            <begin position="24"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="520"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="564" mass="64959" checksum="679739C6951DD3B3" modified="2022-01-19" version="1">MDPSYSCEKGLCILFFLVCIASGHRYQYEFSYHDILTGHQVTLKTKEVSTTQREFIIEGERNTDLLQLNNVRTPFGTFRWYIPSITRANFSFCIRARFSYPSYPRVPPPRLRAVWVNHNINFREPSSGTGIWCVGMLPGFNNSCCHKFSIACPRDGFKLVHTHWQEVKWRPMSWHDTGRYAQQMRHRRSLRPHVSYELGHYRYWTDNSHVSIMQSFAQNLNVSDCWICSALPRSVAHGVYLIGIPIHVNTTIGHIWNTTILRSNFTTHALSLAHTRLENNIYIHCVENRDSTGTYLGNWTLRCDNLAAVKNRNQLILSLPGAYWLCREHAYRILPKKWRGRYTLGLVVPNMEIIPREINGTLWHRSFYGRTKRTILNPLIERLTGFHAFVRWFIPGLGVSELEKAILNVSGEVEKLANATAYGLLTIQGELTNLSKVVLQNRMARDMLLALQGGVCTVLNASRCMYVDQTGELLTDVGKIWEVSKTMQEIQKDDTRWGFSETWHWLTSWLPNLSAIAKKIILIIIVVIVLIVIVYVLIQCCMRMGSALTVKAPPPPKIVFGRYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T357</accession>
    <name>A0A8C2T357_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Family with sequence similarity 91 member A1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FAM91A1</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM91 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T357"/>
    <dbReference type="Ensembl" id="ENSCJPT00005009990.1">
        <property type="protein sequence ID" value="ENSCJPP00005006318.1"/>
        <property type="gene ID" value="ENSCJPG00005005939.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000009543"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099041">
        <property type="term" value="P:vesicle tethering to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039199">
        <property type="entry name" value="FAM91"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028097">
        <property type="entry name" value="FAM91_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028091">
        <property type="entry name" value="FAM91_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28441">
        <property type="entry name" value="PROTEIN FAM91A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28441:SF2">
        <property type="entry name" value="PROTEIN FAM91A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14648">
        <property type="entry name" value="FAM91_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14647">
        <property type="entry name" value="FAM91_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM91 N-terminal" evidence="3">
        <location>
            <begin position="8"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="FAM91 C-terminal" evidence="4">
        <location>
            <begin position="375"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="333"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="667"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="338"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="670"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="849" mass="95320" checksum="F6A36FB2670F6E3E" modified="2022-01-19" version="1">MNIDVEFHIRHNYLWARLPASVKQALGNSQREYERQVVLYSIRNQLRYRNNLVKHVKKDERKYYEDLLKYSRDHLMLYPYHLSDIMVKGLRVTPFSYYTGIMEDIMNSEKSYDSLPNFTAADCLRLLGIGRNQYIDLMNQCRSSKKFFRRKTARDLLPVKPVEITIEAWWVVQSGYITEDDIKICTTSEKSAIDKIIDSGPQLAGSLDFNVVHSLYNKGFIYLDVPISDDSCIAVPPLEGFVMNRVQGDYFETLLYKIFVSIDEHTNVAELANVLEIDLSLVKNAVSMYCRLGFAHKKGQVINLDNLHPSWKNVPSVNRLKSTLDPQKMLLSWDSGENRSPVQEAGSSATDTDTNSQDDPAETASVSSLNLSSGHTKRIAFLFDSTLTAFLMMGNLSPNLKSHAVTMFEVGKLSDESLDSFLVELEKVQSTGEGEAQRYFDHALTLRNTILFLRHNKDLGAQAIQPDQPTNGFPLDLLRCESLLGLDPATCSRVLNKNYTLLVSMAPLTNEIRPISSCTPQHIGPAIPEVSSVWFKLYIYHITGQGPPSLLLSKGTRLRKLPDIFQGYDRLLITSWGHDPGVVPTSNVLTMLNDALTHSAVLIQGHGMHGMGETVHIPFPFDEAEQQGDFSRVNMGIHSALKILRNKVDLQHFCGYVTMLNPTSRQANRKLSDASDGRGDADLASGSDVNGSTESFEMVIEETSMDSAIKQSLEVPTSELEWVPLELCFGIPLFSSELNQKVCRKIATHGLCRKESLQKLLHSSRKLSLQVLNFVHSFQEGTSTLDQLHDAGCSSSLLQPTSADMGVPLPAKNLMFKEGKELKADGEEECCWAWKRGCLCPRNMLSLEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T5F7</accession>
    <name>A0A8C2T5F7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 17">Alpha-1,3/1,6-mannosyltransferase ALG2</fullName>
            <ecNumber evidence="5 17">2.4.1.132</ecNumber>
            <ecNumber evidence="4 17">2.4.1.257</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">ALG2</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;3)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29515"/>
            <dbReference type="Rhea" id="RHEA-COMP:19511"/>
            <dbReference type="Rhea" id="RHEA-COMP:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58472"/>
            <dbReference type="ChEBI" id="CHEBI:132510"/>
            <dbReference type="EC" id="2.4.1.132"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:29516"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;6)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:79023"/>
            <dbReference type="Rhea" id="RHEA-COMP:19511"/>
            <dbReference type="Rhea" id="RHEA-COMP:19514"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58472"/>
            <dbReference type="ChEBI" id="CHEBI:229641"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:79024"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>an alpha-D-Man-(1-&gt;3)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29519"/>
            <dbReference type="Rhea" id="RHEA-COMP:19513"/>
            <dbReference type="Rhea" id="RHEA-COMP:19515"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:132510"/>
            <dbReference type="ChEBI" id="CHEBI:132511"/>
            <dbReference type="EC" id="2.4.1.257"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:29520"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>an alpha-D-Man-(1-&gt;6)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:79027"/>
            <dbReference type="Rhea" id="RHEA-COMP:19514"/>
            <dbReference type="Rhea" id="RHEA-COMP:19515"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:132511"/>
            <dbReference type="ChEBI" id="CHEBI:229641"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:79028"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 17">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Endoplasmic reticulum membrane</location>
            <topology evidence="1 17">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.132" evidence="5 17"/>
    <dbReference type="EC" id="2.4.1.257" evidence="4 17"/>
    <dbReference type="RefSeq" id="XP_015710667.1">
        <property type="nucleotide sequence ID" value="XM_015855181.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T5F7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005011935.1">
        <property type="protein sequence ID" value="ENSCJPP00005007780.1"/>
        <property type="gene ID" value="ENSCJPG00005007072.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107309970"/>
    <dbReference type="KEGG" id="cjo:107309970"/>
    <dbReference type="CTD" id="85365"/>
    <dbReference type="GeneTree" id="ENSGT00550000075033"/>
    <dbReference type="OrthoDB" id="448893at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
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        <property type="term" value="C:cytoplasmic side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004378">
        <property type="term" value="F:GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102704">
        <property type="term" value="F:GDP-Man:Man(2)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd03805">
        <property type="entry name" value="GT4_ALG2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000085">
        <property type="entry name" value="alpha-1,3/1,6-mannosyltransferase ALG2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="alpha-1,3/1,6-mannosyltransferase ALG2"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027054">
        <property type="entry name" value="ALG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45918">
        <property type="entry name" value="ALPHA-1,3/1,6-MANNOSYLTRANSFERASE ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45918:SF1">
        <property type="entry name" value="ALPHA-1,3_1,6-MANNOSYLTRANSFERASE ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 17" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Glycosyltransferase subfamily 4-like N-terminal" evidence="19">
        <location>
            <begin position="25"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="18">
        <location>
            <begin position="218"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00050465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU367136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005007780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="412" mass="46697" checksum="F679136FED416755" modified="2022-01-19" version="1">MAEREEEEEGTGPSVLFLHPDLGLGGAERLVVDAALALQARGCRVQVWTAHYDPQRCFAETRRLAVHCAGDWLPRSLCGRGHAVCAALRMAFVALYVLLLSGQSADAFICDQVSACIPILRLARRRKKVLFYCHFPDQLLTKRESFLKRLYRKPLDWLEEYTTGMADCIVVNSKFTAGVFKETFKSLSHINPDVLYPSLNTDSFETVVPVDITDLIPKKTKFLFLSINRYERKKNLALALEALHELRGRLDSQQWSEVHLVMAGGYDKRVLENVEHYEELRRIATKLNVSDHVTFLRSFTDEQKVSLLNNCVCVLYTPSNEHFGIVPLEAMYMRCPVIAVNSGGPLESILNNVTGFLCDPLPTQFSEAMEKIVRDPLLKDSMGAAGRVRFMEKFSSEAFSEQLYQYICKLTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T6F4</accession>
    <name>A0A8C2T6F4_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Bromodomain containing 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BRD3</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the BET family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_032303925.1">
        <property type="nucleotide sequence ID" value="XM_032448034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T6F4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005013765.1">
        <property type="protein sequence ID" value="ENSCJPP00005009196.1"/>
        <property type="gene ID" value="ENSCJPG00005008115.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107321861"/>
    <dbReference type="KEGG" id="cjo:107321861"/>
    <dbReference type="CTD" id="8019"/>
    <dbReference type="GeneTree" id="ENSGT00940000153385"/>
    <dbReference type="OrthoDB" id="21449at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140017">
        <property type="term" value="F:histone H3K18cr reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140038">
        <property type="term" value="F:histone H3K27cr reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140019">
        <property type="term" value="F:histone H3K9cr reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062072">
        <property type="term" value="F:histone H3K9me2/3 reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106222">
        <property type="term" value="F:lncRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140693">
        <property type="term" value="F:molecular condensate scaffold activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035987">
        <property type="term" value="P:endodermal cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071168">
        <property type="term" value="P:protein localization to chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd05497">
        <property type="entry name" value="Bromo_Brdt_I_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05498">
        <property type="entry name" value="Bromo_Brdt_II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000003">
        <property type="entry name" value="Bromodomain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.220:FF:000001">
        <property type="entry name" value="bromodomain-containing protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000002">
        <property type="entry name" value="Bromodomain-containing protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043508">
        <property type="entry name" value="Bromo_Brdt_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043509">
        <property type="entry name" value="Bromo_Brdt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050935">
        <property type="entry name" value="Bromo_chromatin_reader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027353">
        <property type="entry name" value="NET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038336">
        <property type="entry name" value="NET_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880:SF246">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880">
        <property type="entry name" value="FALZ-RELATED BROMODOMAIN-CONTAINING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17035">
        <property type="entry name" value="BET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51525">
        <property type="entry name" value="NET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="2" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Bromo" evidence="7">
        <location>
            <begin position="47"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="7">
        <location>
            <begin position="322"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="NET" evidence="8">
        <location>
            <begin position="558"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="232"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="412"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="633"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="250"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="417"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="442"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="483"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="500"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="519"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="651"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="688"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005009196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="722" mass="79658" checksum="DDF886A401E62F87" modified="2022-01-19" version="1">MSAVTSAIQAPQGPVNPPPPEVTNPNKPGRKTNQLQYMQNVVVKTLWKHQFAWPFYQPVDAIKLNLPDYHKIIKNPMDMGTIKKRLEHNYYWSASECMQDFNTMFTNCYIYNKPTDDIVLMAQALEKIFLQKVAQMPQEEVELLPPVPKGKGRKPSVGTQSTGAQQAVAVSSVSPPAPFQSVPPAVSQTPVIAATPVPTITANVPPVTAPPAAAPPPPAAPIMPVVPPTPPVVKKKGVKRKADTTTPTTSVITASRSESPTPLSDPKQAKIIARRESGGRPIKPPKKDLEDGEVPQHAGKKGKLSEHLKYCDSILKEMLSKKHAAYAWPFYKPVDAEALELHDYHDIIKHPMDLSTVKKKMDSREYQDAQGFAADIRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEPAEAPPPPPPTAPVVSKSTESSHSSEESSSDSDSSDSEEERATRLAELQEQLKAVHEQLAALSQAPVNKPKKKKEKKEKEKKKKDKEKEKEKHKVKAEEEKKPKVAQPPKQAQQKKAPAKKANSTTTASRQPKKGGKQASATYDSDEEEEGLPMTYDEKRQLSLDINRLPGEKLGRVVHIIQSREPSLRDSNPDEIEIDFETLKPSTLRELERYVKSCLQKKQRKPFSASGKKQAAKSKEELAQEKKKELEKRLQDVSGQLNNNKKPAKKDKSGSAPSGGPSRLSSSSSSESGSSSSSGSSSDSSDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T6K7</accession>
    <name>A0A8C2T6K7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cas scaffolding protein family member 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">CASS4</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Docking protein that plays a role in tyrosine kinase-based signaling related to cell adhesion and cell spreading. Regulates PTK2/FAK1 activity, focal adhesion integrity, and cell spreading.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts (via SH3 domain) with PTK2/FAK1 (via C-terminus).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Focal adhesion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CAS family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015737321.1">
        <property type="nucleotide sequence ID" value="XM_015881835.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T6K7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005012270.1">
        <property type="protein sequence ID" value="ENSCJPP00005008014.1"/>
        <property type="gene ID" value="ENSCJPG00005007253.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107323091"/>
    <dbReference type="CTD" id="57091"/>
    <dbReference type="GeneTree" id="ENSGT00950000183008"/>
    <dbReference type="OrthoDB" id="5983572at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990782">
        <property type="term" value="F:protein tyrosine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051897">
        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900026">
        <property type="term" value="P:positive regulation of substrate adhesion-dependent cell spreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd11568">
        <property type="entry name" value="FAT-like_CASS4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11551">
        <property type="entry name" value="Serine_rich_CASS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12000">
        <property type="entry name" value="SH3_CASS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.830:FF:000001">
        <property type="entry name" value="BCAR1 scaffold protein, Cas family member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000147">
        <property type="entry name" value="Cas scaffold protein family member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.230">
        <property type="entry name" value="Alpha-catenin/vinculin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.830">
        <property type="entry name" value="Serine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021901">
        <property type="entry name" value="CAS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037362">
        <property type="entry name" value="CAS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035744">
        <property type="entry name" value="CASS4_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014928">
        <property type="entry name" value="Serine_rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038319">
        <property type="entry name" value="Serine_rich_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10654">
        <property type="entry name" value="CAS SCAFFOLDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10654:SF19">
        <property type="entry name" value="CAS SCAFFOLDING PROTEIN FAMILY MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12026">
        <property type="entry name" value="CAS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08824">
        <property type="entry name" value="Serine_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="8" id="KW-0965">Cell junction</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="15">
        <location>
            <begin position="3"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="365"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="610"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="407"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="417"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00064074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00071492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005008014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="810" mass="89783" checksum="629D486681578FC2" modified="2022-01-19" version="1">MKVNNALAKALYDNKAECSDELAFRRGDILTVLEQHVVGSEGWWRCSLHGRQGLAPANRLQLLVGPQALPPPAIPSDAPEPPVAPQNIYQVPSVPKGTASSSTYEKMEGWVTSPARAATQPAQGVYQVPALAAQLLSERTRSCKQQHLFTLPRACRASVPNITSEVYDVPSMQSRESLLTQSGATPPASRKVSVLARSPKCFQEEQQLYNVPSSSEKSGAVIQDSAVGNLYDVPPKRETDAAEKKSQKKFWGHCNTLPNPRKSEWIYDIPISPEKTGIKQNSSVHSTENQVLYDIPPARYKALTTNAEANVVNPQLYDIPPTQRKLTFPDVPLYDVPSSKDVLLQQNGSCDVPPSLLASNAENQISGGNVYDVPKGLPTTIQSKKGMEKNSNRSGNQAYHVPPQLSRDTKPEHDRLSVSSVDSRSSTLSTSSDSSSESSSVSSSEEPATEIKLDLEVAIETLTRLQHSVSSSVASLMIFVSSKWRLQEHLEKNIEEIHRAIDHIKVSLGEFLAFARALKVNASYLTDNNLQIRIKKQLEILLNSFQILTETREALNNCNWSLDVLVLKKPYNNPDDLDRFVMVARTIPDDLKRFVSIIIANGKLLFRKNEKEQDMKQPRVSPGSKMPKQIMAPRRIETDPLPVNAPDKPNPSQGSNETTKENVTEDCEYVQLQVLPSTKKNEVRSQPDSAKKVVVPEQCRLCFGALHKAIAVFNNSLSSQQPPEVFISHSKLIIMVGQKIVDSLCQETQLREARSDILHSSSRFCSLLKNLALATKNAAIQYPNADAMRELQIKSDELSKYTQQFRAMLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T6Y9</accession>
    <name>A0A8C2T6Y9_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutamate rich 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ERICH1</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015714825.1">
        <property type="nucleotide sequence ID" value="XM_015859339.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T6Y9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005013884.1">
        <property type="protein sequence ID" value="ENSCJPP00005009286.1"/>
        <property type="gene ID" value="ENSCJPG00005008171.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107312153"/>
    <dbReference type="KEGG" id="cjo:107312153"/>
    <dbReference type="CTD" id="157697"/>
    <dbReference type="GeneTree" id="ENSGT00390000005606"/>
    <dbReference type="OrthoDB" id="6151351at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026719">
        <property type="entry name" value="ERICH1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22444">
        <property type="entry name" value="GLUTAMATE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22444:SF1">
        <property type="entry name" value="GLUTAMATE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005009286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="401" mass="44467" checksum="71070AA245B178AF" modified="2022-01-19" version="1">MAGSRKEVVEYLGKETSVKEKVFIKNVLKRLYPETSPSPVHVLSGKEEAVLINLGSKSKKNDLENVQVLSADAGTSSGTLSKSSQGSDSTIPPPRRVYTVSPPPEGYVAAVADTDNITVSENSEGSADSSDEEHEVQTKRKRIRRKKLKNSLQDSNILHGEQVESGMQETLVEDNLQLQQIDSSKISKNKRRKMKKKRQKEKMRAAGLLTKTTSVDFTYQPDKNNREGASDLKDTDEKADSILDFLQATQQIYFADNKSKCSDSTVNSAAQELLQCLESRNVSSLDVTLLHQMKSLVLLRDIDRLKDALKQFQEHSMMPPGTEIQQRLRNNGYPSAENDTWVYKVAADSSCRKNSHQLIGHNAATGSLAPGRVWDQSLQLQHTPAGSTEETFRDPLSCAGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T7C6</accession>
    <name>A0A8C2T7C6_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Coiled-coil domain containing 33</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CCDC33</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015728260.1">
        <property type="nucleotide sequence ID" value="XM_015872774.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T7C6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005013154.1">
        <property type="protein sequence ID" value="ENSCJPP00005008713.1"/>
        <property type="gene ID" value="ENSCJPG00005007760.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107318662"/>
    <dbReference type="KEGG" id="cjo:107318662"/>
    <dbReference type="CTD" id="80125"/>
    <dbReference type="GeneTree" id="ENSGT00390000017366"/>
    <dbReference type="OrthoDB" id="552574at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039889">
        <property type="entry name" value="CCD33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21623:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21623">
        <property type="entry name" value="SPERIOLIN-BINDING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="190"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="255"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="578"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="393"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="536"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="265"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005008713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="615" mass="68459" checksum="0B3A7BFB067FCD39" modified="2022-01-19" version="1">MAGESRIPASLQRWRLRAEDKVLDFEFEVLSAQFNRRGRYALRLSVENPLLRDSGDNVRLRIGDGDSVPSSTGTTDTVLQGHLGEICAFQRKKFTFTLPRGYCKNDKNHDVRLHIEALHCPGTLLRRRRVGEAFFAIYPRPDQPRVKLLAGRDEDWYRYSAVLALLRAGSEQPAMHCGRLAFTAALHEHRPPANVSPAPSPRAQERGHQAASTAPSPASPAGPSPSVPLQSPESAYHSLPTEVPQADAVLSSSLDLRGDSTGEQSSSSSSSSLGPPLSFHLSSPESSLDPSPCAVQLHRDAVALPPTDALSTILPRTQQRSQDVPQEREVSRYRLALRRMAGDLVSLHQRVTSLEVENGHLRHSLAGRQEPGHALLTDGDVDVMTREEVLDRLATMKGELVSSTAEMRQLRDRVQQLQNELIRKNDQEKELVLLQRAHKQQQAALRRCQAEVARTKGLEEVVRQQEKVIRVMEQMLQEKLSRGAEKPAGEVPAGQLHTQLLAENRRLREELVRPTFPPLPSGTPLPPQDTFSGTEKLSLLAKLEEAQARGRAMERQLEEAARRWAREKQELGTRLLEQDHGFGGSAPHFLHATTLKRPPEPTLPPRRPRTLDPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T7G5</accession>
    <name>A0A8C2T7G5_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Bone morphotic protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">BMP5</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the TGF-beta family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015714712.1">
        <property type="nucleotide sequence ID" value="XM_015859226.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T7G5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005013214.1">
        <property type="protein sequence ID" value="ENSCJPP00005008761.1"/>
        <property type="gene ID" value="ENSCJPG00005007795.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107312103"/>
    <dbReference type="KEGG" id="cjo:107312103"/>
    <dbReference type="CTD" id="653"/>
    <dbReference type="GeneTree" id="ENSGT00940000158644"/>
    <dbReference type="OrthoDB" id="5987191at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070700">
        <property type="term" value="F:BMP receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905069">
        <property type="term" value="P:allantois development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097065">
        <property type="term" value="P:anterior head development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030509">
        <property type="term" value="P:BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048738">
        <property type="term" value="P:cardiac muscle tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060411">
        <property type="term" value="P:cardiac septum morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051216">
        <property type="term" value="P:cartilage development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043583">
        <property type="term" value="P:ear development"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003272">
        <property type="term" value="P:endocardial cushion formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061384">
        <property type="term" value="P:heart trabecula morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030902">
        <property type="term" value="P:hindbrain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030539">
        <property type="term" value="P:male genitalia development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032348">
        <property type="term" value="P:negative regulation of aldosterone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000065">
        <property type="term" value="P:negative regulation of cortisol biosynthetic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043569">
        <property type="term" value="P:negative regulation of insulin-like growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021502">
        <property type="term" value="P:neural fold elevation formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001503">
        <property type="term" value="P:ossification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007389">
        <property type="term" value="P:pattern specification process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003344">
        <property type="term" value="P:pericardium morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060037">
        <property type="term" value="P:pharyngeal system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900006">
        <property type="term" value="P:positive regulation of dendrite development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050679">
        <property type="term" value="P:positive regulation of epithelial cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060391">
        <property type="term" value="P:positive regulation of SMAD protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003323">
        <property type="term" value="P:type B pancreatic cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd19395">
        <property type="entry name" value="TGF_beta_BMP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.90.10:FF:000003">
        <property type="entry name" value="Bone morphogenetic protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001839">
        <property type="entry name" value="TGF-b_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001111">
        <property type="entry name" value="TGF-b_propeptide"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015615">
        <property type="entry name" value="TGF-beta-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017948">
        <property type="entry name" value="TGFb_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848:SF139">
        <property type="entry name" value="BONE MORPHOGENETIC PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848">
        <property type="entry name" value="TGF-BETA FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00019">
        <property type="entry name" value="TGF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00688">
        <property type="entry name" value="TGFb_propeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00204">
        <property type="entry name" value="TGFB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00250">
        <property type="entry name" value="TGF_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51362">
        <property type="entry name" value="TGF_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0891">Chondrogenesis</keyword>
    <keyword evidence="3" id="KW-0202">Cytokine</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 11" id="KW-0339">Growth factor</keyword>
    <keyword evidence="6" id="KW-0892">Osteogenesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034697773" evidence="13">
        <location>
            <begin position="24"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="TGF-beta family profile" evidence="14">
        <location>
            <begin position="333"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="316"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="331"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005008761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="453" mass="51614" checksum="B6A0ECB08A2026F9" modified="2022-01-19" version="1">MNLTALKAFVGLLWNCWVLVGHAQGGLGDNHVHSSFIYRRLRNHERREIQREILSILGLPHRPRPFSPGKQASSAPLFMLDLYNAMTNEEDTEELDYSLKGSMAGESRGMRKGYPASPNGYSRRIQLSRMTTLATQNPPLASLHDTNFLNDADMVMSFVNLVERDKDFSHQRRHYKEFRFDLTQIPHGEAVTAAEFRIYKDRSNSRFENETIQISIYQIIKEYPNRDADLFLLDTRKAQASDVGWFVFDITVTSNHWVINPQNNLGLQLCAETGDGRSINVKSAGLIGRHGPQSKQPFMVAFFKASEVLFRSVRAANNKRKNQNRNKSSSHQESSRMPSVGDYNTSEQKQACKKHELYVSFRDLGWQDWIIAPEGYAAFYCDGECSFPLNAHMNATNHAIVQTLVHLMFPDHVPKPCCAPTKLNAISVLYFDDSSNVILKKYRNMVVRSCGCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T8R2</accession>
    <name>A0A8C2T8R2_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc finger C2HC-type containing 1B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ZC2HC1B</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T8R2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005014750.1">
        <property type="protein sequence ID" value="ENSCJPP00005009897.1"/>
        <property type="gene ID" value="ENSCJPG00005008668.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161511"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026319">
        <property type="entry name" value="ZC2HC1A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049899">
        <property type="entry name" value="Znf_C2HC_C3H"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13555">
        <property type="entry name" value="C2H2 ZINC FINGER CGI-62-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13555:SF36">
        <property type="entry name" value="ZINC FINGER C2HC DOMAIN-CONTAINING PROTEIN 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13913">
        <property type="entry name" value="zf-C2HC_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52027">
        <property type="entry name" value="ZF_C2HC_C3H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2HC/C3H-type" evidence="6">
        <location>
            <begin position="5"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="C2HC/C3H-type" evidence="6">
        <location>
            <begin position="108"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS52027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005009897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="227" mass="25593" checksum="7C7ED9BA2638A90D" modified="2022-01-19" version="1">VGSQDLVPCRICGRQFAQDVLMRHEPICKKVFNKKRKPFNSFKQRLQGTDIGTVKRQPLLKNQPVKKSNWRQHHEDFINAIKSAKEVTKAMQEGRPLPPPPPPSINPDYIQCPFCLRRFNEAAAEKHIRFCEEQAARRAIAAKITKQPVVTKHPTVTILPYLLISYDAFEAGLQLVVLKRAHPEVTTTSPSAWGPTTASPKADLGWRIPWASCFGRASFLSRSPSFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T982</accession>
    <name>A0A8C2T982_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome b5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">CYB5A</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Microsome membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12 14">Belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T982"/>
    <dbReference type="Ensembl" id="ENSCJPT00005012455.1">
        <property type="protein sequence ID" value="ENSCJPP00005008174.1"/>
        <property type="gene ID" value="ENSCJPG00005007362.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156770"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000002">
        <property type="entry name" value="Cytochrome b5 type B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050668">
        <property type="entry name" value="Cytochrome_b5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359:SF150">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 14" id="KW-0349">Heme</keyword>
    <keyword evidence="9 14" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0492">Microsome</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="15">
        <location>
            <begin position="14"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005008174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="171" mass="19402" checksum="D28A3153BE0FD6E8" modified="2022-01-19" version="1">MVGSSEAGGEKWRGRYYRLEEVQKHNNSQSTWIIVHNRIYDITKFLDEHPGGEEVLREQAGGDATENFEDVGHSTDARALSETFIIGELHPDDRPKLQKPAETLITTVQSNSRYSMASGTKYEIPHNNVSEVQNIMASLCRKHRCGRVLLHNKSHFVYSPVWHLCASLHAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T9R4</accession>
    <name>A0A8C2T9R4_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Retinoic acid receptor gamma</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">RARG</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T9R4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005013495.1">
        <property type="protein sequence ID" value="ENSCJPP00005008984.1"/>
        <property type="gene ID" value="ENSCJPG00005007958.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156458"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
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                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
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                <person name="Wilson R.K."/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="537"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="618"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="746"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="759"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="949"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1142"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1232"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1421"/>
            <end position="1451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1476"/>
            <end position="1500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1569"/>
            <end position="1584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1587"/>
            <end position="1600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1602"/>
            <end position="1611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1612"/>
            <end position="1627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1665"/>
            <end position="1682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1691"/>
            <end position="1700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1705"/>
            <end position="1714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1790"/>
            <end position="1800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005009606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1820" mass="203128" checksum="9E01B641C6D1D876" modified="2022-01-19" version="1">MATRVEINSTLASLTTVPDLNEIRTEDKSQRVYVSVLSDVSSKAKEPSASLTLEEKSKFGSTLRSATMPSLGSRPRLFPKPFSKDTPSDTFANVKPPITSFRTSSLIRKPSEETTSAKVSAGNVPPLVDQKVIGNESKAGGEVVTNMTFYSGHNTNTVILFETAGTEQSKVSLAQGKRAADDHRVLSTIQTKESQSNVKQEKPSQPSHETSRSPEGSLHRQILLSSSVRPVSWNSLKTGEKKDAPEDRSVEKTNTDANNINNKVGISLDVQQRPKPRPVSAVFLESLRDQTHRTVEASEEKSPTEKSWVRKPRPLSMDLTAKFELKDLSTSKKACSSHESKETVSVTSFTDVGSHGQSETGPKTEEIEFNKGSSSKTNLKCSSQEISILNKGKHTWETKQKSESEQTETKPSIVTNLYSSERAFESAGESRTNREGKRLDQKETCVFLSCESPAASSEKENSIVRGSVKKHISLFTSENPGASVDTETLPSAAERENKCVNIQQRIKELTTESTDAKPGNLRRSLQSRPLSADLTKMFSSPTSSTSEVKPEKAAEVRNNSGSEMQEHQKSKEITMLAHREDPTEAHAAGNPWKSRQVVKITNRTDQTETKGSFPGDSQRFSQQSENSISFTSSFEKRLKPTNVTEKTCIKTVRATMFDHNVQRHNVADDLPGTVSPLKMSGELEAKPDVVTLGHTRRSWVGEAFPSKSPSRDPNDFFSSECTLSERKKDLDKTETDPVLIAEKIPYSTNRNKSSGVNEKTSKLHAEIKTDRSEDSSTDGTGRSNLVKCSSEKSSFRQRGVDYEFGPSFGHEVVSTSVKKQQVHSSSVLLSGQLCKSSSSLHPDVKEESRAFAVRRSLDSNFKDQDLGLHSTAPENREKIRAIDPEEKVRRTKSSISDLKTSERWRRKTLPHDSVKAEEISWLTPDNTKRLSWTDSLQLEENSLKKRNIKERMEGHEAKQTAPGSSDEHLKNQSSTLEPKATYFAVTYQISSIKKEKSFVGTAGTSVSSKISSSSEGGAVNVGPDFPGRSKPDKSIVSMDCREESREVYVKKDWVKGEDKDNASSKNIASSNFHVSGKDKCYEKGLDQAKEKIIDVDAFLLKQERENVAQTDVKSSRGKVSTYHEPRSSLHFAQLHKEGEVVTQKSSESSCGVSGRKAEDGYRLQVLDIDALMAEYKEESVKGGSIQDKVSEEHSLFGRSKSKNKRNVSDRVSSSYTWKEWKGSDHYAVSSKQGERVEEYHRPEKLVPTEKSKEKLDSHGPESDKQKSKDKKLGSPPWENPSCLFPDKFANSPVEFTAKKTFIIDDDQDVNLTSRNQSSQAVIDKVQPVHAVGVDQKLEVNFASRLSIKANDGLLQRKVVTKEQFSEVTLEGDWSKNVARSSVTKNRDDVNKVTCANDSSNVKSKTKDWKSSTSGLGSATPDLRRSYSEKSRPGKDGPSHMQEVRGKKELYRSRQSFPPESVDNGWKTKVVSQSESYFHEDKKAPRKEWTKQSSEKTDGREFSFVSTQRRSHSFFYKDRRTESITDQLKQCFTRQPPEAKDTDTLVQEPDSQYGTWSEQRRSGDSFVPESPSSENDVISTRKQPPNSQPSSLSSQTEPTSLADRCDFSKDQRSTSLDRSSTDIDSTDGTELPPPGDAYPDGKTTDFSFIDQTTILDSSALKNRVQLSKKRRHRAPLSHSVRRSRGLEYDNRFSLTEESGSTWMFKDSTEEKKPMQQEDSDEEEKTQRSGRLSSVQAQRLPIFPGMDHSVLKAQLRKRHESESPGEPSSAQPFKSPKPQLGTPGSRILPSSVEKEERSEEKSPQWLKELKSKKRQSHYENQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TAQ6</accession>
    <name>A0A8C2TAQ6_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Tropomyosin 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">TPM1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the tropomyosin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_032302741.1">
        <property type="nucleotide sequence ID" value="XM_032446850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TAQ6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005015193.1">
        <property type="protein sequence ID" value="ENSCJPP00005010214.1"/>
        <property type="gene ID" value="ENSCJPG00005008946.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107318467"/>
    <dbReference type="CTD" id="7168"/>
    <dbReference type="GeneTree" id="ENSGT01030000234542"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000005">
        <property type="entry name" value="Tropomyosin alpha-1 chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000001">
        <property type="entry name" value="Tropomyosin alpha-1 chain isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000001">
        <property type="entry name" value="Tropomyosin alpha-1 chain isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000533">
        <property type="entry name" value="Tropomyosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19269">
        <property type="entry name" value="TROPOMYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00261">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00194">
        <property type="entry name" value="TROPOMYOSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00326">
        <property type="entry name" value="TROPOMYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0514">Muscle protein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005010214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="284" mass="32715" checksum="74251A413FFE3389" modified="2022-01-19" version="1">MEAIKKKMQMLKLDKENAMDRAEQAEADKKAAEERSKQLEDELVALQKKLKGTEDELDKYSESLKDAQEKLELADKKATDAESEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMEIQEMQLKEAKHIAEEADRKYEEVARKLVIIEGDLERAEERAELSESKCAELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEEIKVLTDKLKEAETRAEFAESSVAKLEKSIDDLEDELYAQKLKYKAISEELDHALNDMTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TD15</accession>
    <name>A0A8C2TD15_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C-factor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC107323276</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015737661.1">
        <property type="nucleotide sequence ID" value="XM_015882175.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TD15"/>
    <dbReference type="Ensembl" id="ENSCJPT00005017258.1">
        <property type="protein sequence ID" value="ENSCJPP00005011854.1"/>
        <property type="gene ID" value="ENSCJPG00005010129.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107323276"/>
    <dbReference type="KEGG" id="cjo:107323276"/>
    <dbReference type="GeneTree" id="ENSGT00940000165046"/>
    <dbReference type="OrthoDB" id="7289984at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05325">
        <property type="entry name" value="carb_red_sniffer_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF7">
        <property type="entry name" value="NADB-LER2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005011854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="253" mass="27495" checksum="53CDADC67CDA09EC" modified="2022-01-19" version="1">MAQPRCRSVLITGCSRGIGLGLVRGLAAADPSPEVVFATCRYPDKAQELQQLSKQYSNIKLLQLDVVCENSIKKVVKEVEEIVGDKGLNCLINNAGINVLASLEDVTAETMLTIYETNTVAQLMVTKAFLPLLRKAAQLSTGMGCHRAAIINMSSLAASMQLVQANEMFLKVYPYRIAKTALNMITRCLAADLKSDGILCISLHPGWVQTDMGGNMAPLQVQEAIPGILSVLDRLGEKENGSFLDWQGETLPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TEN3</accession>
    <name>A0A8C2TEN3_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">CUGBP Elav-like family member 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">CELF5</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CELF/BRUNOL family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015741714.1">
        <property type="nucleotide sequence ID" value="XM_015886228.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TEN3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005016612.1">
        <property type="protein sequence ID" value="ENSCJPP00005011363.1"/>
        <property type="gene ID" value="ENSCJPG00005009760.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107325406"/>
    <dbReference type="KEGG" id="cjo:107325406"/>
    <dbReference type="CTD" id="60680"/>
    <dbReference type="GeneTree" id="ENSGT00940000154201"/>
    <dbReference type="OrthoDB" id="410044at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd12632">
        <property type="entry name" value="RRM1_CELF3_4_5_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12635">
        <property type="entry name" value="RRM2_CELF3_4_5_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12639">
        <property type="entry name" value="RRM3_CELF3_4_5_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000007">
        <property type="entry name" value="CUGBP Elav-like family member 4 isoform 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000010">
        <property type="entry name" value="CUGBP Elav-like family member 4 isoform 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000069">
        <property type="entry name" value="CUGBP Elav-like family member 5 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034648">
        <property type="entry name" value="CELF3/4/5/6_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 9" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="54"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="143"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="410"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005011363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="495" mass="53700" checksum="FAEE0F708EAF7CCD" modified="2022-01-19" version="1">MARLREGEARIQPQPPPLPPAPQPPPPRRASPMSSSGGAEPPAQPDSMKDLDAIKLFVGQIPRNLEEKDLKPLFEQFGKIYELTVLKDRYTGMHKGCAFLTYCARDSAIKAQTALHEQKTLPGMARPIQVKPADSESRGGRDRKLFVGMLNKQQSEDDVLRLFEPFGVIDECTVLRGPDGNSKGCAFVKFSSHTEAQAAIHALHGSQTMPGASSSLVVKFADTDKERTLRRMQQMVGQLGIFTPSLTLPFSPYSAYAQALMQQQTTVLSTSHGSYLSPGVAFSPCHIQQIGAVSLNGLQAAPIAQTSGLHSPPLLGTTAMPGLVAPISNGFTGVVPFPNGHPSLETVYTNGFVPYSAQSPSVAETLHPAFTGVQQYAAVYPTTSITPIAQSIPQPPPVLQQQQREGPEGCNLFIYHLPQEFGDTELMQMFLPFGNVISSKVFVDRATNQSKCFGFVSFDNPSSAQTAIQAMNGFQIGMKRLKVQLKRPKDANHPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TG17</accession>
    <name>A0A8C2TG17_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TG17"/>
    <dbReference type="Ensembl" id="ENSCJPT00005016943.1">
        <property type="protein sequence ID" value="ENSCJPP00005011588.1"/>
        <property type="gene ID" value="ENSCJPG00005009961.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005011588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="72" mass="8646" checksum="0D9F11AC3B8B4FDF" modified="2022-01-19" version="1">VRTFPFLGQFVYVIFSLVIPARNKNHREKCLQEYAECTHTQKLSELEIRLHCLYTLMPCSRAYYFRSLKEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TGD4</accession>
    <name>A0A8C2TGD4_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cryptic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC107306284</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TGD4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005016260.1">
        <property type="protein sequence ID" value="ENSCJPP00005011079.1"/>
        <property type="gene ID" value="ENSCJPG00005009555.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162302"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome Z"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000421">
        <property type="entry name" value="Teratocarcinoma-derived growth factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019011">
        <property type="entry name" value="Cryptic/Cripto_CFC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09443">
        <property type="entry name" value="CFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 5" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034640741" evidence="6">
        <location>
            <begin position="26"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005011079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="194" mass="22172" checksum="C1E0590526D76689" modified="2022-01-19" version="1">MYSRKHVGILFTVTLIWQAIHIGEGREKEDHENDVKNLNVTAQKQHPKNSVTIIDAFSDMNQSYQSRKHQNSMEFVPFTGITESKNLNRNCCQNGGTCILGAFCACPKHFSGRHCELRKCGSIAHGDWVMKGCWLCRCLYGTLKCLSQNTQDSCGKEQRREEEIIRLYSKGLRSQQTVSALICFLTFILELCCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TI52</accession>
    <name>A0A8C2TI52_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Plasmalemma vesicle associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">PLVAP</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015742264.1">
        <property type="nucleotide sequence ID" value="XM_015886778.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TI52"/>
    <dbReference type="Ensembl" id="ENSCJPT00005019020.1">
        <property type="protein sequence ID" value="ENSCJPP00005013193.1"/>
        <property type="gene ID" value="ENSCJPG00005011152.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107325667"/>
    <dbReference type="KEGG" id="cjo:107325667"/>
    <dbReference type="CTD" id="83483"/>
    <dbReference type="GeneTree" id="ENSGT00390000006166"/>
    <dbReference type="OrthoDB" id="9944409at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002693">
        <property type="term" value="P:positive regulation of cellular extravasation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043114">
        <property type="term" value="P:regulation of vascular permeability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009538">
        <property type="entry name" value="PV-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21687">
        <property type="entry name" value="PLASMALEMMA VESICLE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21687:SF5">
        <property type="entry name" value="PLASMALEMMA VESICLE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06637">
        <property type="entry name" value="PV-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="152"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="294"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005013193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="415" mass="47257" checksum="15DF4FEC90B197FD" modified="2022-01-19" version="1">MEKSSYGMAKFGLESKQAMPKRDCAFYMRYVFLFTSLIQFLIILGLVLFMVYGNAHAGTDNYVRQLDGRLQEQYQKIITLSGRNANLTRTLNATLKANQGLQGQLQKVQGQLDKCNSSQAPNSNPRLEDMNRTIIFQKTHLEKCYMGINLINIKCANEKQQLQQQLDMATQQRKELGQNCSTAETALDKAKQEKERCQMDLKVAGAHCVTTKGELDHLRRECDTLSSNVLYNLRTMSMSNKNFGCSQVEEQLRLLMHRIEELFSRQQQHESNYVGKSVCDLTLQQCHLNCSHEKQELGKRLQEVQQQLQGSQEERRKLLADKEKLSKELDEKSKVAAQANYFSQQLSLCMSSKVGTYYTAPWVPGSAVGSVRSGPFPSSYADLLQNQDKINTEEIQKVVQNVLEQYTAMMRNPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TIF4</accession>
    <name>A0A8C2TIF4_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NFKB inhibitor epsilon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">NFKBIE</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TIF4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005017571.1">
        <property type="protein sequence ID" value="ENSCJPP00005012099.1"/>
        <property type="gene ID" value="ENSCJPG00005010303.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159120"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001650">
        <property type="term" value="C:fibrillar center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051059">
        <property type="term" value="F:NF-kappaB binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071356">
        <property type="term" value="P:cellular response to tumor necrosis factor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051070">
        <property type="entry name" value="NF-kappa-B_inhibitor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46680">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46680:SF5">
        <property type="entry name" value="NFKB INHIBITOR EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="146"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="179"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="219"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="253"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="286"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005012099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="353" mass="37647" checksum="B832F695FA7444BC" modified="2022-01-19" version="1">SPRLRKGPAEAGDGQCDSGIESLRSLPGGRDNPAPADTPTLTEPPTPAGGTPTAAGENRTPCEPPTPSEERLDSSYSSGALPEALPTAEPPPPPDGSNRRQLEALTYVSEDGDTLVHLAIIHCVPDVALCCIAQLPRELLEIQNDLFQTPLHLAVYLEQPSVVQALIHKGVNPGLQDRNGNTPLHLACEQQRLRCARQLLQGTAEPPGHSQDLQLQNWQGLACLHISTLKGNIQMMSLLLQSGANIDVQEGTSGKTPLHMAVECHNRSAVQFLLHNGAYVDAQMYNGCTPLHLAVGRKDAAIAAILSHSGADTLLRNMENETAQDLADGNDDLLALLPFDDLKISGKPVMCSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TIP4</accession>
    <name>A0A8C2TIP4_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Kynurenine 3-monooxygenase</fullName>
            <ecNumber evidence="16">1.14.13.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Kynurenine 3-hydroxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16 19" type="primary">KMO</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 16">
            <text>L-kynurenine + NADPH + O2 + H(+) = 3-hydroxy-L-kynurenine + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:20545"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:58125"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.13.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="16">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 16">Mitochondrion outer membrane</location>
            <topology evidence="2 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the aromatic-ring hydroxylase family. KMO subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.9" evidence="16"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2TIP4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005020206.1">
        <property type="protein sequence ID" value="ENSCJPP00005014138.1"/>
        <property type="gene ID" value="ENSCJPG00005011818.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000000747"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00328"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004502">
        <property type="term" value="F:kynurenine 3-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016174">
        <property type="term" value="F:NAD(P)H oxidase H2O2-forming activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043420">
        <property type="term" value="P:anthranilate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070189">
        <property type="term" value="P:kynurenine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006569">
        <property type="term" value="P:L-tryptophan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019805">
        <property type="term" value="P:quinolinate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009651">
        <property type="term" value="P:response to salt stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="Kynurenine 3-monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
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    </dbReference>
    <dbReference type="HAMAP" id="MF_01971">
        <property type="entry name" value="Kynurenine_monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027545">
        <property type="entry name" value="Kynurenine_monooxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46028">
        <property type="entry name" value="KYNURENINE 3-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46028:SF2">
        <property type="entry name" value="KYNURENINE 3-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0274">FAD</keyword>
    <keyword evidence="3 16" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13 16 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 16" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 16" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="11 16" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8 16" id="KW-0521">NADP</keyword>
    <keyword evidence="10 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 16" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="421"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="18">
        <location>
            <begin position="10"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
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            <dbReference type="ARBA" id="ARBA00023002"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023128"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00047818"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00059455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005014138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="477" mass="54924" checksum="12891085B5C6825E" modified="2022-01-19" version="1">MESSNVQGKKVAIVGGGLVGALNACFFAKRGFHVDVYEAREDIRVSSFARGRSINLALSYRGRQALQAVGLEEQIVSKGIPMHARRIHTLLGKKYSIPYGKKNQYILSVDRANLNRELLTAAEKYSNTNLYFGHKLIECNAELGTLTIKRSGQLPLEDTYDLIVGCDGAFSTVRKQFMRQTCFNYSHEYIPHGYMELTIPPRDGDFAMEPNYLHIWPRNTFMMIALPNMDKSFTCTLFMPFEEFEKLKTGEQVLDFFQTYFPDSIPLIGEQELKHDFFLLPAQAMISVKCSSYHLSNRCVLMGDAAHAVVPFYGQGMNAGFEDCLVFDELMDQFHNDLGACLPEFSRLRVPDDHAISDLAMYNYVEMREHVNSTWFIFRKRINNLLHTLMPSTIIPLYTMVTFSRIRYHEVLQRWKWQEKIINRGLFIMGAAGLGGTYLLVKRLTRDWCFFIPNLWGWCHYIRNIGNFPFSIQVAQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TJ26</accession>
    <name>A0A8C2TJ26_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Anion exchange protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">SLC4A5</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 hydrogencarbonate(out) + Na(+)(out) = 2 hydrogencarbonate(in) + Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:72215"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>3 hydrogencarbonate(out) + Na(+)(out) = 3 hydrogencarbonate(in) + Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:72219"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Basolateral cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the anion exchanger (TC 2.A.31) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015738472.1">
        <property type="nucleotide sequence ID" value="XM_015882986.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015738473.1">
        <property type="nucleotide sequence ID" value="XM_015882987.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015738474.1">
        <property type="nucleotide sequence ID" value="XM_015882988.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032304751.1">
        <property type="nucleotide sequence ID" value="XM_032448860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TJ26"/>
    <dbReference type="Ensembl" id="ENSCJPT00005020383.1">
        <property type="protein sequence ID" value="ENSCJPP00005014294.1"/>
        <property type="gene ID" value="ENSCJPG00005011938.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107323668"/>
    <dbReference type="KEGG" id="cjo:107323668"/>
    <dbReference type="CTD" id="57835"/>
    <dbReference type="GeneTree" id="ENSGT00940000157488"/>
    <dbReference type="OrthoDB" id="1735926at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008509">
        <property type="term" value="F:monoatomic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008510">
        <property type="term" value="F:sodium:bicarbonate symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005452">
        <property type="term" value="F:solute:inorganic anion antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.570:FF:000001">
        <property type="entry name" value="Anion exchange protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.930.10:FF:000002">
        <property type="entry name" value="Anion exchange protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.570">
        <property type="entry name" value="Helical hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.930.10">
        <property type="entry name" value="Mannitol-specific EII, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013769">
        <property type="entry name" value="Band3_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011531">
        <property type="entry name" value="HCO3_transpt-like_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003020">
        <property type="entry name" value="HCO3_transpt_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003024">
        <property type="entry name" value="Na/HCO3_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016152">
        <property type="entry name" value="PTrfase/Anion_transptr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00834">
        <property type="entry name" value="ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453">
        <property type="entry name" value="ANION EXCHANGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453:SF20">
        <property type="entry name" value="ELECTROGENIC SODIUM BICARBONATE COTRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07565">
        <property type="entry name" value="Band_3_cyto"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00955">
        <property type="entry name" value="HCO3_cotransp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01231">
        <property type="entry name" value="HCO3TRNSPORT"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01232">
        <property type="entry name" value="NAHCO3TRSPRT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55804">
        <property type="entry name" value="Phoshotransferase/anion transport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="500"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="534"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="585"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="618"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="722"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="753"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="808"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="848"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="908"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="934"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="985"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="domain" description="Band 3 cytoplasmic" evidence="16">
        <location>
            <begin position="111"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="15">
        <location>
            <begin position="471"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1042"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1119"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="233"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1127"/>
            <end position="1140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00035820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00036309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF07565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005014294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1140" mass="128121" checksum="9B97F81F613B156D" modified="2022-01-19" version="1">MLEDEDGLSERGLSSSRRRYDDEEDYHSIYIGVPVPRGYRRKRRRRRSASSRDRTSESERHYERQERSDTDDGGGHGCYESGNDNASRTMSPAAERLRYILGDDDEPPNPTLFTEMDTLQHDGEEMEWKESARWIKFEEKVEEGGERWSKPHVSTLSLHSLFELRTCLQTGTVLLDLDGYSLPQIIDDVIEKQIEDGLLKPELREKISYVLLRKHRHQTKKPIHRSLADIGKSVSSNTNRSPVRSPAAGAAFHRSTEDLRMRQSASYGRLRHVQSRSMNDISDTPSTDQLKNKFIKKIPKDAEASNVLVGEVEFLEKPFVAFVRLLQATMLGGVTEVPVPTRFLFILLGPAGKAKSYNEIGRAIATLMVDDLFSDVAYKARDREDLIAGIDEFLDEVIVLPPGEWDPNIRIEPPKKVPSAEKRKSVFSLNEVGQMNGTAGGAGAGSGGGGSDDGEMPEVHEIGEELAWTGRFCGGLYLDIKRKLPWFPSDFYEGFHIQSISAILFIYLGCITNAITFGGLLGDATDNYQGVMESFLGTAMAGSMFCLFAGQPLIILSSTGPILIFEKLLFDFSKGNGIDYMEFRLWIGLHSALQCLILVATDASFIIKYITRFTEEGFSTLISFIFIYDAIKKMIGAFKYYPINSDFKPDYVTMYKCECIAPDPANMTLFDASVPVAANTTNTSLYNAINLTALDWTQLSKKECLKYGGSLVGKSCKFVPDLALMSFILFFGTYSMTLTLKKFKFSRYFPTKVRAFIADFSNVFSILLFCGVDACFGLDTPKLHIPSIIKPTRVDRGWFVFPFGKNPWWVYLASALPALLVTILIFMDQQITAVIVNRKEHKLRKAAGYHLDLFWVGILMAVCSFMGLPWYVAATVISIAHIDSLKMETETSAPGEQPQFLGVREQRVTGIIVFVLTGISVFLAPILKYIPMPVLYGVFLYMGVASLNGIQFWDRCKLFLMPAKHQPDYVFLRHVPLRRIHLFTLVQIICLAVLWILKSTVAAIIFPVMILALILVRRLLDFVFSQHDLAWIDNIIPEKEKKKEDDKKKKKKGNKGDSSSDEEERGPPPGALRSDSSPNGSDMDRSITLHLKISCPSSPAFNYSRSPICAVPQVKIEMESDYEDTDTEKPPRDMGSETTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TJN7</accession>
    <name>A0A8C2TJN7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cadherin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TJN7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005019600.1">
        <property type="protein sequence ID" value="ENSCJPP00005013674.1"/>
        <property type="gene ID" value="ENSCJPG00005011505.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013164">
        <property type="entry name" value="Cadherin_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08266">
        <property type="entry name" value="Cadherin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034859983" description="Cadherin N-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin N-terminal" evidence="3">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005013674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="74" mass="7881" checksum="3CA6D6AA8023BDD9" modified="2022-01-19" version="1">ISLHQPSLGCWCCRRLWAAVWAVGQVRYSVPEEAEAGTVVGRLWQDLGLGGEAKDGGAAACVWCSRGPAGRVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TJZ9</accession>
    <name>A0A8C2TJZ9_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Rab GTPase-activating protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">GAP and centrosome-associated protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Rab6 GTPase-activating protein GAPCenA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">RABGAP1</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">May act as a GTPase-activating protein of RAB6A. May play a role in microtubule nucleation by centrosome. May participate in a RAB6A-mediated pathway involved in the metaphase-anaphase transition.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with RAB6A and tubulin gamma.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015734691.1">
        <property type="nucleotide sequence ID" value="XM_015879205.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015734692.1">
        <property type="nucleotide sequence ID" value="XM_015879206.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TJZ9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005018462.1">
        <property type="protein sequence ID" value="ENSCJPP00005012785.1"/>
        <property type="gene ID" value="ENSCJPG00005010864.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107321834"/>
    <dbReference type="KEGG" id="cjo:107321834"/>
    <dbReference type="CTD" id="23637"/>
    <dbReference type="GeneTree" id="ENSGT00940000157216"/>
    <dbReference type="OrthoDB" id="295078at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01211">
        <property type="entry name" value="PTB_Rab6GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.750:FF:000004">
        <property type="entry name" value="Putative rab gtpase-activating protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000125">
        <property type="entry name" value="Putative rab gtpase-activating protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000007">
        <property type="entry name" value="Rab GTPase-activating protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000001">
        <property type="entry name" value="TBC1 domain family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022164">
        <property type="entry name" value="Kinesin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF6">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12473">
        <property type="entry name" value="DUF3694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PID" evidence="16">
        <location>
            <begin position="152"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Rab-GAP TBC" evidence="17">
        <location>
            <begin position="566"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="483"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="800"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="993"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="489"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="510"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00056651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00063354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00072920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00078554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00082331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005012785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1069" mass="121802" checksum="84613F955DE9A903" modified="2022-01-19" version="1">MDDKASVGKISVSSDSVSTLNSEDFVLVSRQGDETPSTNNGSDDEKTGLKIVGNGSEQQLQRELEDVLMDPPMEDQSCDRDHGYEVRTDGDGEEPVVLEASASSTINPVSVAGLQKPEMSLPVKPSQGDCGDLSPFTPVTDEDSVVFSKLTYLGCASVNAPRSEVEALRMMCILRSQCQISLDVTLSVPNVSEGTVRLLDPQTNTEIANYPIYKILFCVRGHDGTPECDCFAFTESHYNAELFRIHVFRCEIQEAVSRILYSFATAFRRSAKQTPLSAIATPQTPDSDIFTFSVSLEIKEDDGKGYFSAVPKDKDRQCFKLRQGIDKKIVIYVQQTTNKELAIERCFGLLLSRGKDVRSGDMHLLDLESMGKSSDGKSYVITGSWNQKSPHFQFVNEETPKDKVLFMTTAVDLVITEVQEPVRFILETKVRVCSPNERLFWPFSKRSSTENFFLKLKQIKQKDRKNNSDTLYEVVCLESESERERRKTTASPSLRLPQSGSQGSMIPSPPEDDEEEDNDEPLLSGSGDVSKECAEKILETWGELLSKWHLNLSVRPKTLSALVRSGVPEALRGEVWQLLAGCHNNDHLVEKYRILITKESPQDSAITRDINRTFPAHDYFKDTGGDGQDSLYKICKAYSVYDEEIGYCQGQSFLAAVLLLHMPEEQAFSVLVKIMFDYGLRELFKQNFEDLHCKFYQLERLMQEYIPDLYNHFLDISLEAHMYASQWFLTLFTAKFPLYMVFHIIDLLLCEGISVIFNVALGLLKTTKDDLLLTDFEGALKFFRVQLPKRYRSEENAKKLMELACNMKISQKKLKKYEKEYHTMREQQAQQEDPIERFERENRRLQEANMRLEQENDDLAHELVTSKIALRKDLDNAEEKADALNKELLMTKQKLIDAEEEKRRLEEESAQLKEMCRRELDKAESEIKKNSSIIGDYKQICSQLSERLEKQQTANKAEIEKIRQKVDDCEHCREFFNKEGRVKVASSAKDGSDDDTDEEKETLKNQLREMELELAQTKLQLVEAECKIQDLEHHLGLALNEVQAAKKTWFNRTISSIKTVTGVQGKETC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TLP1</accession>
    <name>A0A8C2TLP1_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Semaphorin 3G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">SEMA3G</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the semaphorin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015730125.1">
        <property type="nucleotide sequence ID" value="XM_015874639.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TLP1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005020789.1">
        <property type="protein sequence ID" value="ENSCJPP00005014625.1"/>
        <property type="gene ID" value="ENSCJPG00005012193.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107319641"/>
    <dbReference type="KEGG" id="cjo:107319641"/>
    <dbReference type="CTD" id="56920"/>
    <dbReference type="GeneTree" id="ENSGT00940000157677"/>
    <dbReference type="OrthoDB" id="9988752at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045499">
        <property type="term" value="F:chemorepellent activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030215">
        <property type="term" value="F:semaphorin receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030517">
        <property type="term" value="P:negative regulation of axon extension"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001755">
        <property type="term" value="P:neural crest cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071526">
        <property type="term" value="P:semaphorin-plexin signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05871">
        <property type="entry name" value="Ig_Sema3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000015">
        <property type="entry name" value="Semaphorin 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000030">
        <property type="entry name" value="Semaphorin 3F like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1680.10">
        <property type="entry name" value="ligand-binding face of the semaphorins, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041416">
        <property type="entry name" value="IL-1RAcP-like_ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016201">
        <property type="entry name" value="PSI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001627">
        <property type="entry name" value="Semap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036352">
        <property type="entry name" value="Semap_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027231">
        <property type="entry name" value="Semaphorin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036">
        <property type="entry name" value="SEMAPHORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036:SF20">
        <property type="entry name" value="SEMAPHORIN-3G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18452">
        <property type="entry name" value="Ig_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01403">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00423">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00630">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103575">
        <property type="entry name" value="Plexin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101912">
        <property type="entry name" value="Sema domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51004">
        <property type="entry name" value="SEMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034891571" evidence="10">
        <location>
            <begin position="17"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="domain" description="Sema" evidence="12">
        <location>
            <begin position="23"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="588"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005014625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="761" mass="86053" checksum="57389138030EDD32" modified="2022-01-19" version="1">MRAAAALSWLWGALLAAGSSPPRLRLPYRELLGTNRSVLFFGHRGFLGFRSLYVDEYRDRLFIGGKDVLYSLRLDKASTDTKEIYWPPLPGQTEECFQKGKDPATDCANYIRLLQPYNRTHLLACGTGACHPVCTFIYVGHRGETQHAFSLDPGSMESGRGRCPHEPDRAFASIIIGGELYAGLTADFLGRDPGIFRSTGTRSALRTEVDQRLLNDPKFVAAYMIPDNDDRDDDKAYFFFTEKVVEADSREHTIVSRVARVCVNDAGGQRVLVNKWSTFNKARLVCSVPGPDGIDTHFDELEDVFLLRTKDGKNPEIYALFSTVSHVFQGSAVCVYRMADIREVFNGPFAHQDSPLHQWGAYEGRVPYPRPGVCPSKTTNQPRRPYSSTKELPDEVLHFARAHPLMYRAVRPRHHRPLLVKTDLQHRLRQLVVDRVDTEDGQHDVLFLGTDAGSVLKVVVLQKQNSAVMEEVVLEELQVFKVPVPITQMEISVKRQKLYVGASLGVAQVQLHQCKSYGTACAECCLARDPYCAWDGTTCTRYQPSGKRRYVRHTSSVHQCLDQNLTVDDLEHVEEKVLYGMEHNSTFLECVPRSPQATVQWFVQRPPDEQRDEVKTDERVLQTEQGLLFRQLHRRDAGVYYCKTLEHGFTQTVARTALEVLGGEQLARAAPRQREDRRPLCPEPWMAAPAPKTWYKDILHLASSADRQRVEEQCLRLWCGHRKGKMAKGKHTLAGMDVGKKGRVAKPQGERIRVPRQAAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TMI9</accession>
    <name>A0A8C2TMI9_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein NipSnap homolog 3A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC107306431</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NipSnap family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015705084.1">
        <property type="nucleotide sequence ID" value="XM_015849598.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TMI9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005021347.1">
        <property type="protein sequence ID" value="ENSCJPP00005015021.1"/>
        <property type="gene ID" value="ENSCJPG00005012485.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107306431"/>
    <dbReference type="KEGG" id="cjo:107306431"/>
    <dbReference type="GeneTree" id="ENSGT00950000183018"/>
    <dbReference type="OrthoDB" id="10262843at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome Z"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000017">
        <property type="entry name" value="Protein NipSnap homolog 3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000019">
        <property type="entry name" value="Protein NipSnap homolog 3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012577">
        <property type="entry name" value="NIPSNAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051557">
        <property type="entry name" value="NipSnap_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21017">
        <property type="entry name" value="NIPSNAP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21017:SF19">
        <property type="entry name" value="PROTEIN NIPSNAP HOMOLOG 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07978">
        <property type="entry name" value="NIPSNAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NIPSNAP" evidence="2">
        <location>
            <begin position="40"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="NIPSNAP" evidence="2">
        <location>
            <begin position="149"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="250" mass="28255" checksum="0798723DDB61DA19" modified="2022-01-19" version="1">MLSPAALRRPLAAAARLARGNPQVFASLATGPRQDNGIFYEIRTYDVKPSKMKEFVELVHKFLHLRTAHSELVGYWTTELGAMNKAVHVWKYDNFAHRTAVRHALANDKEWQGQFISSALPLIEKQHNEVAYLVPWCQLGKPPKEGGVYEWVTFQMKPGGPALWGEAFQAAINAHINTGYTKLIGVFHTEYGLLNTVHVIWWNESPDHRAAGRHRAHEDARVVAAVRDSVRFLESQKNMLLTPLAFSPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TMR2</accession>
    <name>A0A8C2TMR2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Doublecortin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TMR2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005022418.1">
        <property type="protein sequence ID" value="ENSCJPP00005015866.1"/>
        <property type="gene ID" value="ENSCJPG00005013101.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154895"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035082">
        <property type="term" value="P:axoneme assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007417">
        <property type="term" value="P:central nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042461">
        <property type="term" value="P:photoreceptor cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060041">
        <property type="term" value="P:retina development in camera-type eye"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.230:FF:000001">
        <property type="entry name" value="serine/threonine-protein kinase DCLK1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.230:FF:000002">
        <property type="entry name" value="serine/threonine-protein kinase DCLK2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.230">
        <property type="entry name" value="Doublecortin domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003533">
        <property type="entry name" value="Doublecortin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036572">
        <property type="entry name" value="Doublecortin_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23005:SF4">
        <property type="entry name" value="OXYGEN-REGULATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23005">
        <property type="entry name" value="RETINITIS PIGMENTOSA 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03607">
        <property type="entry name" value="DCX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00537">
        <property type="entry name" value="DCX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89837">
        <property type="entry name" value="Doublecortin (DC)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50309">
        <property type="entry name" value="DC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Doublecortin" evidence="7">
        <location>
            <begin position="30"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Doublecortin" evidence="7">
        <location>
            <begin position="135"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="258" mass="29114" checksum="2F4726F035071DB2" modified="2022-01-19" version="1">NRANITTFQLPKTSQDPFRTDPFPFLGQCFRSFEALLADLTRTLSDNVNLPQGVRTIYTIDGSKKISSLDQLVEGESYVCGSIEPFKKLEYMKNVNPNWSVNVKTTSTSHSVLSLATAKGGTPDTKENKDFIRPKLVTIIRSGVKPRKAGRILLNKKTSHSFEQVLTNITDAIKLDSGVVKRLYTLDGKQVMCLQDFFSLFPFPFLGHQPCATAAPPPRPARCPSPPRRSPRRRAALYGYFLFRRLPATHPLEDRKWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TMX1</accession>
    <name>A0A8C2TMX1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial</fullName>
            <shortName evidence="1">Glu-AdT subunit C</shortName>
            <ecNumber evidence="1">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">GATC</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-glutamyl-tRNA(Gln) + L-glutamine + ATP + H2O = L-glutaminyl-tRNA(Gln) + L-glutamate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GatC family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2TMX1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005022887.1">
        <property type="protein sequence ID" value="ENSCJPP00005016261.1"/>
        <property type="gene ID" value="ENSCJPG00005013378.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000018351"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070681">
        <property type="term" value="P:glutaminyl-tRNAGln biosynthesis via transamidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00122">
        <property type="entry name" value="GatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036113">
        <property type="entry name" value="Asp/Glu-ADT_sf_sub_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003837">
        <property type="entry name" value="GatC"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00135">
        <property type="entry name" value="gatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15004">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT C, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15004:SF0">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT C, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02686">
        <property type="entry name" value="GatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141000">
        <property type="entry name" value="Glu-tRNAGln amidotransferase C subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005016261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="139" mass="15286" checksum="1F779372C3218B85" modified="2022-01-19" version="1">PAARDVGAGVMAGTAGRDGESTQDQRDGVTMEVLDHLERLALVDFRDADGVERLRDAVRFAERLREVDTEGVQPMDSVLEDRCLYLREDDVTEGNCTAQLLKNATEKVEEYFVAPPGTIMWAKNIPQSPFSISVGKNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TNS9</accession>
    <name>A0A8C2TNS9_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pre-mRNA-splicing factor ISY1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ISY1</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="4">Identified in the spliceosome C complex. Component of the XAB2 complex, a multimeric protein complex composed of XAB2, PRPF19, AQR, ZNF830, ISY1, and PPIE. Identified in a pentameric intron-binding (IB) complex composed of AQR, XAB2, ISY1, ZNF830 and PPIE that is incorporated into the spliceosome as a preassembled complex. The IB complex does not contain PRPF19. Interacts with CPSF3; this interaction is in an RNA independent manner. Interacts with the microprocessor complex subunits DGCR8 and DROSHA; this interaction is in an RNA dependent manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ISY1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015730222.1">
        <property type="nucleotide sequence ID" value="XM_015874736.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TNS9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005022041.1">
        <property type="protein sequence ID" value="ENSCJPP00005015561.1"/>
        <property type="gene ID" value="ENSCJPG00005012874.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107319681"/>
    <dbReference type="KEGG" id="cjo:107319681"/>
    <dbReference type="CTD" id="57461"/>
    <dbReference type="GeneTree" id="ENSGT00390000014109"/>
    <dbReference type="OrthoDB" id="1739576at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.660:FF:000001">
        <property type="entry name" value="pre-mRNA-splicing factor ISY1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009360">
        <property type="entry name" value="Isy1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037200">
        <property type="entry name" value="Isy1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13021">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ISY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06246">
        <property type="entry name" value="Isy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140102">
        <property type="entry name" value="ISY1 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="196"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="220"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00065310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00070851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="280" mass="32372" checksum="77A146A6C167FDA1" modified="2022-01-19" version="1">MARNAEKAMTALARFRQAQLEEGKVKERRPFLASECNELPKAEKWRRQIIGEISKKVAQIQNAGLGEFRIRDLNDEINKLLREKGHWEVRIRELGGPDYARIGPRMLDHEGKEVPGNRGYKYFGAAKDLPGVRELFEKEPLPPPRKTRAELMKSIDAEYYGYRDEDDGILEPLEQEHEKKVIAEAVEKWKMEREARLARGDEEEEEEVNIYAVDDESDEEGGKEKEGEEGQQKFIAHVPVPSQQEIEEALVRRKKMELLQKYASETLMAQSEEAKRLLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TQ93</accession>
    <name>A0A8C2TQ93_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ras homolog family member D</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TQ93"/>
    <dbReference type="Ensembl" id="ENSCJPT00005022306.1">
        <property type="protein sequence ID" value="ENSCJPP00005015792.1"/>
        <property type="gene ID" value="ENSCJPG00005013033.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158903"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000983">
        <property type="entry name" value="Rho family GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="181" mass="20413" checksum="CE7C788D682EE5B1" modified="2022-01-19" version="1">MQIKAVVVGDGGCGKTSLLMVFARGDFPKVYVPTVFEKYTASFRISGKPAKIHLWDTAGQEDYDRLRPLSYQNTNVVLICFDVTSRSSYDNILTKWYPEVNHFCKDVPVLLVGCKTDLRQGHHQPVTFQEGEAMARQVQAAAYLECSALQQDNVRDVFIKVCTIALRGTLFCKIGENQLWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TQ95</accession>
    <name>A0A8C2TQ95_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Homeobox A2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">HOXA2</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Antp homeobox family. Proboscipedia subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015709379.1">
        <property type="nucleotide sequence ID" value="XM_015853893.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TQ95"/>
    <dbReference type="Ensembl" id="ENSCJPT00005021422.1">
        <property type="protein sequence ID" value="ENSCJPP00005015082.1"/>
        <property type="gene ID" value="ENSCJPG00005012526.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107309252"/>
    <dbReference type="KEGG" id="cjo:107309252"/>
    <dbReference type="CTD" id="3199"/>
    <dbReference type="GeneTree" id="ENSGT00940000155029"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000145">
        <property type="entry name" value="homeobox protein Hox-A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001827">
        <property type="entry name" value="Homeobox_Antennapedia_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45664:SF3">
        <property type="entry name" value="HOMEOBOX PROTEIN HOX-A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45664">
        <property type="entry name" value="PROTEIN ZERKNUELLT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00032">
        <property type="entry name" value="ANTENNAPEDIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5 10 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 10 11" id="KW-0371">Homeobox</keyword>
    <keyword evidence="8 10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="13">
        <location>
            <begin position="138"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="10">
        <location>
            <begin position="140"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="29"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="197"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="255"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="31"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="209"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="255"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="266"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="375" mass="41066" checksum="8D42F25093D066EF" modified="2022-01-19" version="1">MNFEFEREIGFINSQPSLAECLTSFPPVGDTFQSSSIKNSTLSHSTLIPPPFEQTIPSLNPGGHPRHSGGGRPKASPRARSGSPGPAGAPPPPEYPWMKEKKASKRSSLPPASASASAAGPACLSHKDPLEIPDSGNGGSRRLRTAYTNTQLLELEKEFHFNKYLCRPRRVEIAALLDLTERQVKVWFQNRRMKHKRQTQCKENQNGEGKFKGLEDPEKAAEDEEEEKALFEQALGTVSGALLEREGYAFQQNALSQQQAQNAHNGESQSFPVSPLTSNEKNLKHFQHQSPTVQNCLSTMAQNCAAGLNNDSPEALEVPSLQDFNVFSTDSCLQLSDAVSPSLPGSLDSPVDISADSFDFFTDTLTTIDLQHLNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TQB2</accession>
    <name>A0A8C2TQB2_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">ARF like GTPase 4C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ARL4C</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015723309.1">
        <property type="nucleotide sequence ID" value="XM_015867823.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TQB2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005022351.1">
        <property type="protein sequence ID" value="ENSCJPP00005015816.1"/>
        <property type="gene ID" value="ENSCJPG00005013058.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107316404"/>
    <dbReference type="KEGG" id="cjo:107316404"/>
    <dbReference type="CTD" id="10123"/>
    <dbReference type="GeneTree" id="ENSGT00940000160639"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043014">
        <property type="term" value="F:alpha-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd04152">
        <property type="entry name" value="Arl4_Arl7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000458">
        <property type="entry name" value="ADP-ribosylation factor-like protein 4C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0519">Myristate</keyword>
    <keyword evidence="7 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="20"/>
            <end position="27"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="127"/>
            <end position="130"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="192" mass="21533" checksum="A3B2E862F73438F3" modified="2022-01-19" version="1">MGNISSNISAFQSLHIVMLGLDSAGKTTVLYRLQFNEFVNTVPTIGFNTEKIRLSNGTAKGISCHFWDVGGQEKLRPLWKSYSRCTDGIIYVVDSVDVDRLEEAKTELHKVTKFAENQGTPLLVIANKQDLPKSLPVAEIEKQLALHELTPSTTYHIQPACAIIGEGLTEGMDKLYEMILKRRKSLKQKKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TQG4</accession>
    <name>A0A8C2TQG4_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Ras-related protein Rab-17</fullName>
            <ecNumber evidence="6">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">RAB17</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Dendrite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Melanosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Recycling endosome membrane</location>
            <topology evidence="4">Lipid-anchor</topology>
            <orientation evidence="4">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="6"/>
    <dbReference type="RefSeq" id="XP_015723592.1">
        <property type="nucleotide sequence ID" value="XM_015868106.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TQG4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005024054.1">
        <property type="protein sequence ID" value="ENSCJPP00005017227.1"/>
        <property type="gene ID" value="ENSCJPG00005014087.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107316508"/>
    <dbReference type="CTD" id="64284"/>
    <dbReference type="GeneTree" id="ENSGT00940000161839"/>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032839">
        <property type="term" value="C:dendrite cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042470">
        <property type="term" value="C:melanosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098794">
        <property type="term" value="C:postsynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019003">
        <property type="term" value="F:GDP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098937">
        <property type="term" value="P:anterograde dendritic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046847">
        <property type="term" value="P:filopodium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002415">
        <property type="term" value="P:immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032402">
        <property type="term" value="P:melanosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050773">
        <property type="term" value="P:regulation of dendrite development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051489">
        <property type="term" value="P:regulation of filopodium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051963">
        <property type="term" value="P:regulation of synapse assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01860">
        <property type="entry name" value="Rab5_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001282">
        <property type="entry name" value="RAB17, member RAS oncogene family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0966">Cell projection</keyword>
    <keyword evidence="11" id="KW-0967">Endosome</keyword>
    <keyword evidence="15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="18" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-0636">Prenylation</keyword>
    <keyword evidence="14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00067808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005017227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="213" mass="23806" checksum="F3DF77EEF34835E0" modified="2022-01-19" version="1">MAQPAVPGSSLGDNRPTYIYKMVLLGSTSVGKSSLAYRYVKNDFKESLPTVGCSFFTQLIHLETATIKLEIWDTAGQEKYHSVCHLYYRGAHAALLVYDLTNKETLSRAKQWLIELEKEFLPDEIVIALVGNKKDLAEEREVATEDGEEFARSRSLLFMETSAKSNHQVNEIFMAVAQELLRHEGEKAAIPSTGSGQRLDLHANGTRRGCCHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TQR3</accession>
    <name>A0A8C2TQR3_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nucleoside diphosphate kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the NDK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TQR3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005022280.1">
        <property type="protein sequence ID" value="ENSCJPP00005015769.1"/>
        <property type="gene ID" value="ENSCJPG00005013014.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00960000189467"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030308">
        <property type="term" value="P:negative regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045839">
        <property type="term" value="P:negative regulation of mitotic nuclear division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037994">
        <property type="entry name" value="NDPk6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023005">
        <property type="entry name" value="Nucleoside_diP_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46956">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46956:SF1">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00469">
        <property type="entry name" value="NDPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51374">
        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside diphosphate kinase-like" evidence="10">
        <location>
            <begin position="40"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="108" mass="12648" checksum="93F95A4173B41743" modified="2022-01-19" version="1">MNRVRLLYRAPISASYIYITEHGEAYRVTSREFVPPNTSAYGLTDSRNTTHGSDSPASASREIAFFFPEFNEQLWYQQEEPRLRCGQMYYNAEKRVHCVIRDEETDLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TQR8</accession>
    <name>A0A8C2TQR8_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Plastin-3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">T-plastin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">PLS3</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Actin-bundling protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_032300110.1">
        <property type="nucleotide sequence ID" value="XM_032444219.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032300111.1">
        <property type="nucleotide sequence ID" value="XM_032444220.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032300112.1">
        <property type="nucleotide sequence ID" value="XM_032444221.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032300113.1">
        <property type="nucleotide sequence ID" value="XM_032444222.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032300114.1">
        <property type="nucleotide sequence ID" value="XM_032444223.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032300115.1">
        <property type="nucleotide sequence ID" value="XM_032444224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TQR8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005024403.1">
        <property type="protein sequence ID" value="ENSCJPP00005017521.1"/>
        <property type="gene ID" value="ENSCJPG00005014287.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107312588"/>
    <dbReference type="CTD" id="5358"/>
    <dbReference type="GeneTree" id="ENSGT00950000183097"/>
    <dbReference type="OrthoDB" id="431378at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032432">
        <property type="term" value="C:actin filament bundle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051639">
        <property type="term" value="P:actin filament network formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060348">
        <property type="term" value="P:bone development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd21331">
        <property type="entry name" value="CH_PLS3_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21334">
        <property type="entry name" value="CH_PLS3_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21292">
        <property type="entry name" value="CH_PLS_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000059">
        <property type="entry name" value="Plastin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000010">
        <property type="entry name" value="Plastin-3 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000012">
        <property type="entry name" value="Plastin-3 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000014">
        <property type="entry name" value="Plastin-3 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000025">
        <property type="entry name" value="Plastin-3 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039959">
        <property type="entry name" value="Fimbrin/Plastin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19961">
        <property type="entry name" value="FIMBRIN/PLASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19961:SF32">
        <property type="entry name" value="PLASTIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="12">
        <location>
            <begin position="10"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="12">
        <location>
            <begin position="50"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="11">
        <location>
            <begin position="121"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="11">
        <location>
            <begin position="265"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="11">
        <location>
            <begin position="404"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="11">
        <location>
            <begin position="525"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005017521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="637" mass="71857" checksum="2425E8C5856BE1F6" modified="2022-01-19" version="1">MAVTMQISKDELEELKEAFAKVDLNSNGFICDYELHELFKEANLPLPGYKVREIIQKLMIDSDKNKDGKISFEEFVYIFQEVKSSDIAKTFRKAINRKEGICAIGGTSELSSEGTQHSYSEEEKYAFVNWINKALENDPDCRHVIPMNPNTDDLFNAVGDGIVLCKMINLSVPDTIDERAINKKKLTPFIIQENLNLALNSASAIGCHVVNIGAEDLREGKPHLVLGLLWQIIKIGLFADIELSRNEALAALLRDGENLEDLMKLSPEELLLRWANFHLENAGWHKINNFSTDIKLTDFGNSVKDSRAYFHLLNQIAPKGQKEGEPQIDINMSGFNEKDDLRRAEFMLQQAERLGCRQFVTATDVVRGNPKLNLAFIANLFNKYPALTKPENQDIDWTLLEGETREERTFRNWMNSLGVNPHVNHLYGDLQDALVILQLYEKIKVPVDWNKVNKPPYPKLGANMKKLENCNYAVDLGKHPAKFSLVGIGGQDLNDGNPTLTLALVWQLMRRYTLNVLEDLGDGQKANDDIIVNWVNQTLKEAGKSTSIQNFKDKTISTSLAVVDLIDAIQPGCINYDLVKTGHLSEDDKQNNAKYAVSMARRIGARVYALPEDLVEVKPKMVMTVFACLMGRGMKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TSC7</accession>
    <name>A0A8C2TSC7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Voltage-dependent calcium channel gamma-2 subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">CACNG2</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015717706.1">
        <property type="nucleotide sequence ID" value="XM_015862220.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TSC7"/>
    <dbReference type="SMR" id="A0A8C2TSC7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005023373.1">
        <property type="protein sequence ID" value="ENSCJPP00005016661.1"/>
        <property type="gene ID" value="ENSCJPG00005013668.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107313713"/>
    <dbReference type="KEGG" id="cjo:107313713"/>
    <dbReference type="CTD" id="10369"/>
    <dbReference type="GeneTree" id="ENSGT01050000244893"/>
    <dbReference type="OrthoDB" id="9990458at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032281">
        <property type="term" value="C:AMPA glutamate receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098839">
        <property type="term" value="C:postsynaptic density membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098685">
        <property type="term" value="C:Schaffer collateral - CA1 synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036477">
        <property type="term" value="C:somatodendritic compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016247">
        <property type="term" value="F:channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005245">
        <property type="term" value="F:voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051899">
        <property type="term" value="P:membrane depolarization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060081">
        <property type="term" value="P:membrane hyperpolarization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007528">
        <property type="term" value="P:neuromuscular junction development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099590">
        <property type="term" value="P:neurotransmitter receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099645">
        <property type="term" value="P:neurotransmitter receptor localization to postsynaptic specialization membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098943">
        <property type="term" value="P:neurotransmitter receptor transport, postsynaptic endosome to lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051968">
        <property type="term" value="P:positive regulation of synaptic transmission, glutamatergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098970">
        <property type="term" value="P:postsynaptic neurotransmitter receptor diffusion trapping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019226">
        <property type="term" value="P:transmission of nerve impulse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.150:FF:000002">
        <property type="entry name" value="Voltage-dependent calcium channel gamma-2 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051072">
        <property type="entry name" value="CACNG_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004031">
        <property type="entry name" value="PMP22/EMP/MP20/Claudin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005422">
        <property type="entry name" value="VDCC_g2su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008368">
        <property type="entry name" value="VDCC_gsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12107">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12107:SF1">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-2 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00822">
        <property type="entry name" value="PMP22_Claudin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01792">
        <property type="entry name" value="VDCCGAMMA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01602">
        <property type="entry name" value="VDCCGAMMA2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 14" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="5 14" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13 14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="11 14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <keyword evidence="9 14" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="233"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005016661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="323" mass="36053" checksum="13406FCB050CB430" modified="2022-01-19" version="1">MGLFDRGVQMLLTTVGAFAAFSLMTIAVGTDYWLYSRGVCKTKTVSENETSKKNEEVMTHSGLWRTCCLEGNFKGLCKQIDHFPEDADYEADTAEYFLRAVRASSIFPILSVILLFMGGLCIAASEFYKTRHNIILSAGIFFVSAGLSNIIGIIVYISANAGDPSKSDSKKNSYSYGWSFYFGALSFIIAEMVGVLAVHMFIDRHKQLRANARATDYLQSSAITRIPSYRYRYQRRSRSSSRSTEPSHSRDASPVGIKGFNTLPSTEISMYTLSRDPLKATTTPTATYNSDRDNSFLQVHNCIQKENKDSIHTNTANRRTTPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TSX6</accession>
    <name>A0A8C2TSX6_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Gremlin 2, DAN family BMP antagonist</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">GREM2</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DAN family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015713252.1">
        <property type="nucleotide sequence ID" value="XM_015857766.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TSX6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005023677.1">
        <property type="protein sequence ID" value="ENSCJPP00005016925.1"/>
        <property type="gene ID" value="ENSCJPG00005013864.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107311316"/>
    <dbReference type="KEGG" id="cjo:107311316"/>
    <dbReference type="CTD" id="64388"/>
    <dbReference type="GeneTree" id="ENSGT00940000154209"/>
    <dbReference type="OrthoDB" id="10061784at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036122">
        <property type="term" value="F:BMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038098">
        <property type="term" value="P:sequestering of BMP from receptor via BMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.90.10:FF:000013">
        <property type="entry name" value="Gremlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006207">
        <property type="entry name" value="Cys_knot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004133">
        <property type="entry name" value="DAN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15283">
        <property type="entry name" value="GREMLIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15283:SF2">
        <property type="entry name" value="GREMLIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03045">
        <property type="entry name" value="DAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00041">
        <property type="entry name" value="CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0202">Cytokine</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034304812" evidence="9">
        <location>
            <begin position="22"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="CTCK" evidence="10">
        <location>
            <begin position="75"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005016925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="168" mass="19215" checksum="E813CC3DAE89D69C" modified="2022-01-19" version="1">MIWKFAVSVFLMAALARVADSRKNRPAGAIPSPYKDSSSNNSERRQQLNKEVLASSQEALVVTERKYLKSDWCKTQPLRQTVSEEGCISRTIINRFCYGQCNSFYIPRHVKKEEESFQSCAFCKPHKVTSSTVQLECPELDPPFRLKKIQKVKQCRCMSVNLNNSGKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TTL0</accession>
    <name>A0A8C2TTL0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">MAPKAPK2</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="RefSeq" id="XP_015740612.1">
        <property type="nucleotide sequence ID" value="XM_015885126.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TTL0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005025696.1">
        <property type="protein sequence ID" value="ENSCJPP00005018463.1"/>
        <property type="gene ID" value="ENSCJPG00005015040.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107324781"/>
    <dbReference type="KEGG" id="cjo:107324781"/>
    <dbReference type="CTD" id="9261"/>
    <dbReference type="GeneTree" id="ENSGT00940000157261"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070935">
        <property type="term" value="P:3'-UTR-mediated mRNA stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035924">
        <property type="term" value="P:cellular response to vascular endothelial growth factor stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048839">
        <property type="term" value="P:inner ear development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044351">
        <property type="term" value="P:macropinocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038066">
        <property type="term" value="P:p38MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060907">
        <property type="term" value="P:positive regulation of macrophage cytokine production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032760">
        <property type="term" value="P:positive regulation of tumor necrosis factor production"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032675">
        <property type="term" value="P:regulation of interleukin-6 production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034097">
        <property type="term" value="P:response to cytokine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032496">
        <property type="term" value="P:response to lipopolysaccharide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002224">
        <property type="term" value="P:toll-like receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048010">
        <property type="term" value="P:vascular endothelial growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd14170">
        <property type="entry name" value="STKc_MAPKAPK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000094">
        <property type="entry name" value="MAP kinase-activated protein kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000156">
        <property type="entry name" value="MAP kinase-activated protein kinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1170.10:FF:000001">
        <property type="entry name" value="MAP kinase-activated protein kinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1170.10">
        <property type="entry name" value="MAP kinase activated protein kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027442">
        <property type="entry name" value="MAPKAPK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00049">
        <property type="entry name" value="WILMSTUMOUR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="59"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005018463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="395" mass="44743" checksum="A28790FA6476D1BB" modified="2022-01-19" version="1">MLSGAPPPPSGFPSPPPPQPPPPPPPAAPHGPPPPPQFPPFPVKSGLQIRKNAITDDYKVTTQVLGLGINGKVLEIFSKKSGEKFALKMLQDCPKARREVELHWRASQCAHIVRIMDVYENLYQGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAVLKLTDFGFAKETTTHNSLATPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKKRIRMGQYEFPNPEWSEVSEEVKQLIRNLLKTDPTQRMTITEFMNHPWIMQSMQVPQTPLHTSRVLKEEKDLWEDVKEEMTSALATMRVDYEQIKIKKIEDSSNPLLMKRRKKANPAEPAALPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TUN2</accession>
    <name>A0A8C2TUN2_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Autophagy and beclin 1 regulator 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">AMBRA1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the DCX(AMBRA1) E3 ubiquitin ligase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the WD repeat AMBRA1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015719883.1">
        <property type="nucleotide sequence ID" value="XM_015864397.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005023723.1">
        <property type="protein sequence ID" value="ENSCJPP00005016944.1"/>
        <property type="gene ID" value="ENSCJPG00005013782.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107314775"/>
    <dbReference type="CTD" id="55626"/>
    <dbReference type="GeneTree" id="ENSGT00390000016223"/>
    <dbReference type="OrthoDB" id="6363363at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045335">
        <property type="term" value="C:phagocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051020">
        <property type="term" value="F:GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072542">
        <property type="term" value="F:protein phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019903">
        <property type="term" value="F:protein phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990756">
        <property type="term" value="F:ubiquitin-like ligase-substrate adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008406">
        <property type="term" value="P:gonad development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007626">
        <property type="term" value="P:locomotory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043524">
        <property type="term" value="P:negative regulation of neuron apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021915">
        <property type="term" value="P:neural tube development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904544">
        <property type="term" value="P:positive regulation of free ubiquitin chain polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901526">
        <property type="term" value="P:positive regulation of mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051897">
        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045591">
        <property type="term" value="P:positive regulation of regulatory T cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000045">
        <property type="term" value="P:regulation of G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098780">
        <property type="term" value="P:response to mitochondrial depolarisation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048741">
        <property type="term" value="P:skeletal muscle fiber development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000361">
        <property type="entry name" value="Activating molecule in beclin-1-regulated autophagy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052596">
        <property type="entry name" value="AMBRA1_autophagy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22874">
        <property type="entry name" value="ACTIVATING MOLECULE IN BECN1-REGULATED AUTOPHAGY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22874:SF1">
        <property type="entry name" value="ACTIVATING MOLECULE IN BECN1-REGULATED AUTOPHAGY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="91"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="254"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="329"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="378"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="481"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="542"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="592"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="660"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="749"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1062"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1194"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1231"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="254"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="268"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="336"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="378"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="552"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="592"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="630"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="661"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="757"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="775"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1062"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1099"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="1135"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1194"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1274"/>
            <end position="1300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00061691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00062236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005016944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1300" mass="142704" checksum="D12CAC3FBA2E792C" modified="2022-01-19" version="1">MKVVPEKNAVRILWGRERGTQALGAQRLLQELVEDKTRWMKWEGKKVELPDSPRSTFLLAFSPDRTLMASTHVNHNIYITEVKTGKCVHSLVGHRRTPWCVTFHPTIPGLIASGCLDGEVRIWDLHGGSESWFTDSNNAIASLAFHPTAQLLLIATANEIHFWDWSRREPFAVVKTASEMERVRLVRFDPLGHYLLTAIVNPSNQQSDEEVEISVDSTEMPHYRQRAILPSQPVRRTPLLHNFLHMLSSRSSGIQVGEQNSVQDSATPSPPPPPPPPPPPPASENTRASVYNRLRERVSYPTAECCQHLGMLCLCSRCSSARLPSSLFPHQENAPSTSSGATGTSFSSVQTEPYQPPEQASVAQEEQGILNRPSAFSTVQSSAAGNTLRNLSLGPTRRSLSGPLAGHQSRYQQSAREMASGLGGSDWSRTVLNMSSRSELEAMPPPRTSASSVSLLSVLRQQEGGSQASVYTSATEGRGFLAPGAEADSGSGTGPSNPASIRNELQCDLRRFFLEYDGLHELDQGIAGEPSQSQQAQEMLNNNIEPDRPGPSHQQTPHSSENNSSLSRGHLNRCRACHNLLTFNNDTLRWERSTPSYTPGQVQSTFEGVPPNTSQVQPAERTEGRAPASSRLQLGSSSTPQEERTVGVVFNQETGHWERVYSQSASSRPGNVSQEALNQEMPEESSEEDSLRRRLLESSLISLSRYDGAGSREHPIYPDPARLSPAAYYAQRMIQYLSRRDSIRQRSMRYQQNRLRSSSSSSSTSENSSPSVEGNDLEFEDFEDNGDRSRHRAPRNARMSAPSLGRFVPRRFLLPEYLPYAGIFHERGQPGLATHSSVNRVLAGAVIGDGQSAVASNIANTTYRLQWWDFTKFDLPEISNASVNVLVQNCKIYNDASCDISADGQLLAAFIPSSQRGFPDEGILAVYSLAPHNLGEMLYTKRFGPNAISVSLSPMGRYVMVGLASRRILLHPSTEHMVAQVFRLQQPHGGETSMRRVFNVLYPMPADQRRHVSINSARWLPEPGLGLAYGTNKGDLVICRPEALNSGVEYHWDQQNENVFTVHSSSRSTERPGTSRATWRTDRDMGLMNAIGLQPRNPPTSVTSQGTQTLAPQLQNAETQTEREVQEQESTSAGTGEGEGPEYGAGGEDALSRIQRLMAEGGMTAVVQREQSTTMASMGGFGNNIIVSHRIHRSSQTGAESTGAEGTSAHQSTSQQLASELEGRILSESMQLSEHGLSPRTSSGGSEGRGTGDLDLPEQAQPSMDTEGPIEYSDLTNNNHLPDSTNFYSNDSTSGESRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TVS2</accession>
    <name>A0A8C2TVS2_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Golgi phosphoprotein 3 like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">GOLPH3L</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">Golgi stack membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GOLPH3/VPS74 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015740102.1">
        <property type="nucleotide sequence ID" value="XM_015884616.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TVS2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005025765.1">
        <property type="protein sequence ID" value="ENSCJPP00005018527.1"/>
        <property type="gene ID" value="ENSCJPG00005015087.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107324525"/>
    <dbReference type="KEGG" id="cjo:107324525"/>
    <dbReference type="CTD" id="55204"/>
    <dbReference type="GeneTree" id="ENSGT00390000007153"/>
    <dbReference type="OrthoDB" id="2189106at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140312">
        <property type="term" value="F:cargo adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048194">
        <property type="term" value="P:Golgi vesicle budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050714">
        <property type="term" value="P:positive regulation of protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140450">
        <property type="term" value="P:protein targeting to Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3630.10:FF:000004">
        <property type="entry name" value="Probable VPS74-protein involved in protein-vacuolar targeting"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3630.10">
        <property type="entry name" value="yeast vps74-n-term truncation variant domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008628">
        <property type="entry name" value="GPP34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038261">
        <property type="entry name" value="GPP34-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12704:SF4">
        <property type="entry name" value="GOLGI PHOSPHOPROTEIN 3-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12704">
        <property type="entry name" value="TRANS-GOLGI PROTEIN GMX33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05719">
        <property type="entry name" value="GPP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="77"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005018527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="349" mass="39048" checksum="199F2795DBA1BE3F" modified="2022-01-19" version="1">MALWALQQYECEGLVCKNPTSQPGSPQGRMAPWWLRFLVPFLEVQPSESTRHRVAVAAPCCGSAALGQVGMTTLTHRGWRGDKRAEPEEDVAADKELPDDDSDNSKAPRLTLMEEVLLLGLQDKEGYPSFWNDCLSPGLRGGILIELALRGRIHLEPLTARKKRLLDRKVLLKSAAPTGDVLLDETLRHIKAAESIETVQTWIELLTGETWNPFKLQYQLRNVREHVAKGLVEKGILTTGKQSFLLFDMTTHPVCDTTEKQRLLRKLQSSLLERWTGDVRRMERRLLALLVLAHTSDVLEKALGGLEDTQYELAMSRAKDVLEADTELEAAQGRGTEVIWAVLAALSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TVV9</accession>
    <name>A0A8C2TVV9_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Probable JmjC domain-containing histone demethylation protein 2C</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Jumonji domain-containing protein 1C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">JMJD1C</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the JHDM2 histone demethylase family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSCJPT00005027168.1">
        <property type="protein sequence ID" value="ENSCJPP00005019646.1"/>
        <property type="gene ID" value="ENSCJPG00005015908.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158210"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032454">
        <property type="term" value="F:histone H3K9 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="DUF7030"/>
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        <property type="entry name" value="KDM3AB_Tudor"/>
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        <property type="entry name" value="LSDs-like"/>
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    <dbReference type="InterPro" id="IPR054504">
        <property type="entry name" value="PWWP_KDM3B"/>
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        <property type="entry name" value="JMJC DOMAIN-CONTAINING HISTONE DEMETHYLATION PROTEIN"/>
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    <dbReference type="PANTHER" id="PTHR12549:SF6">
        <property type="entry name" value="JMJC DOMAIN-CONTAINING HISTONE DEMETHYLATION PROTEIN 2C-RELATED"/>
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        <property type="entry name" value="DUF7030"/>
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        <property type="entry name" value="JmjC"/>
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        <property type="entry name" value="PWWP_KDM3B"/>
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        <property type="entry name" value="Tudor_KDM3B"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="10" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0804">Transcription</keyword>
    <keyword evidence="13" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
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            <begin position="2267"/>
            <end position="2491"/>
        </location>
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            <begin position="1964"/>
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            <begin position="274"/>
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            <begin position="316"/>
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    <sequence length="2533" mass="282411" checksum="8FCA60FF4EDB87BC" modified="2022-01-19" version="1">MAVAVETRPELVGKRFLCVGGGEEPAESGRWRAGVIRAVSQRDSHSPDLAVYVEFDDLEWEKREWVKVYEDFATFLVEYQLVWAKRKDPSQTQGSKIKQIQWPALTFKPLVGKSVYDSITAVEFLVDKQLDFITEDSAFQPYQDDVDSLNPVLRDNPQLHEEVKAWVKEQKVQEIFMQGPYSLNGYRVRVYRQDSATQWFTGIITHHDLFTRTMVVMNDQVLEPQNVDPSMVQMTFLDDVVHSLLKGENIGITSRRRSRSNQNSNTVHGHYTRAQANSPRPAMNSQTAPKQNSHQQQQQRNTRPNKRKGSDSSMPDEEKVKEERFDYIGRGENPKNKNKHFLSKRRKPEEDEKKLNMKRLRTDNISDYSESSDSEISNKRLTDSSSEQNSENELKSKNTSKINGEEGKSQTAERVEQTLTDRRSPWDEVQEDKKHEEPERLKSSLLDQQEKPSLHAAEQPTPYEQNSKDPHVQECNAEKHHAVELKSEQFVPKPPTPKSIVDKTNKNNSEKESQDNAASTFGLQTVQKIESHSSDLKQQFANANFLEARKQEADQSWVSCVVNKMDLIQPGVVKALPVNEHLNPEKEKVQYGSFMSSLNVASVAEDSKLRKQSPVPDSVKSKPSASVDHPKTKSPDVKPKFTPSSDTVKSKVSSQNSHAPGLTRSANKTDHDLPRSSFHPVPARVSALEATKSPLIIDKNEHFTVYRDPTLIGQETGTNHISPFLHQHNYPLHSSSHRTCLNPNAHHPALTGSSHLLPGSSTQTPLSAINTHPLSTAPHHSVHHPHLLPAVLPGVPAASLLGGHPRLETAHASSLSHLALAHQQQQQMLQHQSPHLLGQAHPSASYNQLGLYPIIWQYPNGTHAYSGLGLPSSKWVHPETPVNAEASLRRNTPSPWLHQPTPVTSADSLGLLSHIPVRPSSAEPLRPLKLAAHSSPPLSKSIVEHHKEELERKAFIEPLRSATAAPIKTELEQSRTQAAKESHMHRHFADPMLNQLPRPPQETGERLSKYKEEHRRILQESIEVAPFTAKIKALEGERENYPRVTSLSSSPKSHSVKYDKDAERSVSELYKMKHSVPQSLPQSNYFTTLSNSVVNEPPRSYPSKEASSAYVDKQTNCPSTAASPQSLPSYISSLSKPPPLIKHQPESEGSVSKVAEQLSQSVQSHSVGSFRSDSRSPTQLSVSSSNTLRSMPALHRAPVFHPPVHQNLEKKESSYSSLSPPTLTPVQPVNAGGGKIQELQKPPTLVPEPKEAQAVYKGSSEQNLSEAWKSNNAAANEKVNWHVERASGKSQSATASVIVRPPSSTKYESVAAVQPASKDRVSERSSAVANQADCLKTAEARETGRVILPNMNSDSARTQYEKKFPAVSQGTVARSVTPTTAMVCSTKMDVTTSAATTTSVLSWGSSEVTYSLSSTALACTPLESAAPRATGQAAAPAQECKGSAPAPAAAAPSKAGSAVQPSPGFSTSADFVHLKKHKAALAAAQFRSCNPSETESNSVKNQTFSTSLSLDSAIVCNTINKANSVGSGQTSQASQPNYHTKLKKAWLTRHSEEDKNTNKKENSGNSVSEIIKPCTVNLIASTSNDLQNNIDSKILADKFVKEDKHPRRKAKRTYESGSESGDSDESESKSEQRTKRQPKPTYKKKQNDLQRKKGDAEEEVKPNGVLSRSAKEKSKLKLQSGSNSTGIPRSVLKDWRKVKKLKQTGESFLQDDSCSEIGPNLQKCRECRLIRSKKGEEPTHSPVFCRFYYFRRLSFSKNGVVRIDGFSSPDQYDDEALSLWTHENYEDDELDLETCKYILDIIGDKFCQLVTSEKTAMSWVKKDAKIAWKRAVRGVREMCDACEATLFNIHWVCQKCGFVVCLDCYKAKERKSSRDKELYAWMKCVKGQPHDHKHLMPTQIIPGSVLTDLLDAMHNIRDKFEIKSHCQCTSKQNMQAGKLPAMNGVSQVLQNVLNHSNKISLCMPESEQQNTPPKSEANGNASPRSDVSTDSKLTPPESQSPLHWLADLAEQKAREEKKENKECPSGKLSKEEKDQDSLESQNCKSSPTASQNNEQGSTLRDLLTTTAGKLRLGSTDAGIAFAPVYSTGTASGKSGRTMPNILDDIIASVVENKIPPNRAPKINVKSEVKDEPKEDRKCIQDDGNKLYSDIQYSWICDKHVLWLRDHKNSNNWKLFKECWKQGRPVLVSGMHKKMNFSLWKAESISLDFGNQQADILNCKDSIISNTNVKEFWDGFEDVSKRQKVKNGETALLKLKDWPSGEDFKAMMPARYEDLLKSLPLPEYCSPEGKLNLASHLPGFFVRPDLGPRLCSAYGVAATKDHDIGTTNLHIEVSDVVNILVYVGIAKGNGVLSKSGVLKKFEEEDLDDLLRKRLKDSSELPGALWHIYAGKDADKIREFLQKIAKEQGLEVLPEHDPIRDQSWYVNKKLRQRLLEEYGVKTCTVIQFLGDAIILPAGALHQVQNFHSCVQVTEDFVSPEHLVQSFHLTQELRLSKEEINYDDKLQVKNILYHAVKEMVRALKIHESEMEDMEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TW34</accession>
    <name>A0A8C2TW34_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carbonic anhydrase</fullName>
            <ecNumber evidence="4">4.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC107319420</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the alpha-carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2TW34"/>
    <dbReference type="Ensembl" id="ENSCJPT00005025499.1">
        <property type="protein sequence ID" value="ENSCJPP00005018293.1"/>
        <property type="gene ID" value="ENSCJPG00005014765.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156978"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="entry name" value="Alpha carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023561">
        <property type="entry name" value="Carbonic_anhydrase_a-class"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018338">
        <property type="entry name" value="Carbonic_anhydrase_a-class_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952:SF25">
        <property type="entry name" value="CARBONIC ANHYDRASE 5B, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01057">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51069">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00162">
        <property type="entry name" value="ALPHA_CA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51144">
        <property type="entry name" value="ALPHA_CA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005018293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="270" mass="31195" checksum="EC79CE1C4F208844" modified="2022-01-19" version="1">MTNSHLWNQYFPIPKPAYNSRGQWRDSVYDPVLKPLKISYDPTTCLHIWNNGYSFLVEFDDSADRSIIVGGPLENQYRLKQFHFHWGAINEWGSEHTVDCKFYPAELHLVHWNAVAYPTFEEAVMEGDGLAVIGVFLKLGAHHEGLQTLVDALPAIKHKDTVIEFDVFDPSCLIPQCPDYWTYAGSLTTPPLTESVTWIIKKQPIEVDENQLEAFRMLLFTSDGEEEKRMVDNFRPLQPLMNRTVRSSFQSRHLLDIEAQYSDHAQQIRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TZ86</accession>
    <name>A0A8C2TZ86_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">XK-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">XKR8</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)</text>
            <dbReference type="Rhea" id="RHEA:38663"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the XK family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TZ86"/>
    <dbReference type="Ensembl" id="ENSCJPT00005026574.1">
        <property type="protein sequence ID" value="ENSCJPP00005019144.1"/>
        <property type="gene ID" value="ENSCJPG00005015569.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01140000282565"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902742">
        <property type="term" value="P:apoptotic process involved in development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043652">
        <property type="term" value="P:engulfment of apoptotic cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070782">
        <property type="term" value="P:phosphatidylserine exposure on apoptotic cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018629">
        <property type="entry name" value="XK-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050895">
        <property type="entry name" value="XK-related_scramblase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16024">
        <property type="entry name" value="XK-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16024:SF8">
        <property type="entry name" value="XK-RELATED PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09815">
        <property type="entry name" value="XK-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="334"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="394"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="453"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="87"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU910716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005019144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="548" mass="58524" checksum="CB1EDFBC43C30078" modified="2022-01-19" version="1">MPQGGCNALLCQAEPQRGVHLPSAAPEAQDEGLHVGCNSPVVHRVLKGSTAAALLIQDPLIQADVWRQLQSSAALYGRRSVLFRRGSPKPGRGAALRGGAVPCRAGRPGDGGSGPGSVRSVAVSAAGGGSRGGGVGRGGGRVGGGGIRSGGAAGLRGAGVGAVGRLLRRPAGLQLVVVPIRSAAAAARAAPAPPGRDARPAARLLLPVPAPSRPPPSQPGAVSAPLSAPCSGRCCRALRLGWRLCRTEPTGEERSHMAFVLHDISMLRLFETFLENAPQLAVLLYSVLRTNKAEPAQGMGICTAFLCVTWSLLDYHQSLRSFLQDKYEMGWGSSVIYFLWNLFLLCPRILALALFALLLPYGVAVHFLLVWLAMFIWVSLQGTDFMESPGPEQLYRAMVAVILYFSWFNVAPGRTLQRSIIYHSFILVDIALLSLAWLWGCPIEEQHPHLKPALWAALSCYVLGLLLRVTYYWWLHPNVRAQPPSGDEVDAHGRADGAVQFRSISEPCEPRGVSQPDLVNSRLRCLARTHFPLAALAEPRLLNGAAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U1Q6</accession>
    <name>A0A8C2U1Q6_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Centrosomal protein 15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">CEP15</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U1Q6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005028883.1">
        <property type="protein sequence ID" value="ENSCJPP00005020987.1"/>
        <property type="gene ID" value="ENSCJPG00005016824.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107319870"/>
    <dbReference type="KEGG" id="cjo:107319870"/>
    <dbReference type="CTD" id="57415"/>
    <dbReference type="GeneTree" id="ENSGT00390000005214"/>
    <dbReference type="OrthoDB" id="9871079at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028006">
        <property type="entry name" value="CEP15-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14286:SF2">
        <property type="entry name" value="CENTROSOMAL PROTEIN 15 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14286">
        <property type="entry name" value="GENE, 49355-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15134">
        <property type="entry name" value="CEP15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005020987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="134" mass="15616" checksum="57A7B3482E385D85" modified="2022-01-19" version="1">MSSYLAQEVHLAKRHEEILSQRSALLQQMETYLGDKKTKKTWQTQAADAARRRNAALLNDIEAAEKKLQERMYLLPHPDTVKLETLYWASVKESLPNWEEFLLGRAEYPIGFKKQKTTKQNISNPEEDSQKQIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U2G0</accession>
    <name>A0A8C2U2G0_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">ATP binding cassette subfamily A member 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ABCA3</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>cholesterol(in) + ATP + H2O = cholesterol(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:39051"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:39052"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="Ensembl" id="ENSCJPT00005030747.1">
        <property type="protein sequence ID" value="ENSCJPP00005022437.1"/>
        <property type="gene ID" value="ENSCJPG00005017457.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155289"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097232">
        <property type="term" value="C:lamellar body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008559">
        <property type="term" value="F:ABC-type xenobiotic transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140345">
        <property type="term" value="F:phosphatidylcholine flippase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U2N1</accession>
    <name>A0A8C2U2N1_COTJA</name>
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        <recommendedName>
            <fullName evidence="14">Sodium/bile acid cotransporter 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Na(+)/bile acid cotransporter 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Solute carrier family 10 member 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">SLC10A4</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Transporter for bile acids.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2U2N1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005028278.1">
        <property type="protein sequence ID" value="ENSCJPP00005020501.1"/>
        <property type="gene ID" value="ENSCJPG00005016503.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182808"/>
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        <property type="component" value="Chromosome 4"/>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008508">
        <property type="term" value="F:bile acid:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="sodium/bile acid cotransporter 4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BilAc:Na_symport/Acr3"/>
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    <dbReference type="InterPro" id="IPR004710">
        <property type="entry name" value="Bilac:Na_transpt"/>
    </dbReference>
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        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10361">
        <property type="entry name" value="SODIUM-BILE ACID COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10361:SF41">
        <property type="entry name" value="SODIUM_BILE ACID COTRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01758">
        <property type="entry name" value="SBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0915">Sodium</keyword>
    <keyword evidence="12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="6" id="KW-0769">Symport</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
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            <begin position="74"/>
            <end position="96"/>
        </location>
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            <end position="130"/>
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    <feature type="transmembrane region" description="Helical" evidence="18">
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    <feature type="transmembrane region" description="Helical" evidence="18">
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            <end position="188"/>
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    <feature type="transmembrane region" description="Helical" evidence="18">
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    <feature type="transmembrane region" description="Helical" evidence="18">
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            <begin position="269"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="16"/>
            <end position="58"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="17">
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            <begin position="378"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00071630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00076517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00082913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005020501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="407" mass="43162" checksum="9496AA91C4D15760" modified="2022-01-19" version="1">RPILAGRLDPAVPYTARCPPSSAAPPASIAGPAPAGGGRRGRGRRWRPSGLRRNTAPRAAADGALGERPLSQGLSVLVGLALCVTMLGLGCAVELGQLGRQLRRPVGVLLALLGQFVAMPLVAFLLALIFALDEVAAVAVLLCGCCPGGNLSNLMSVLVDGDMTLSIIMTASSTLLALLLMPLCLWLYSRPWIHTALVRLLPLGAVSLTLGSTLLPIGMGVLIRYRYPRAADILVKVSLWSLLVTLVILFILTGTMLGPDLLAHIPASVYAIAVLMPLTGYALGYGLATLFRMPPHCRRTVSLETGCQNVQLCTAILKLTFPPQLVGGMYMFPLLYALFQAAEAGLFVLAYKVYGRDGPKQEMLGDEEDTDISYRKLKEEEVPDTSYGTVSTAELGAAPTETTQTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U3N8</accession>
    <name>A0A8C2U3N8_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ribosomal protein S6 kinase</fullName>
            <ecNumber evidence="12">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">RPS6KA3</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="12"/>
    <dbReference type="RefSeq" id="XP_015740793.1">
        <property type="nucleotide sequence ID" value="XM_015885307.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U3N8"/>
    <dbReference type="SMR" id="A0A8C2U3N8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005029479.1">
        <property type="protein sequence ID" value="ENSCJPP00005021473.1"/>
        <property type="gene ID" value="ENSCJPG00005017170.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107324891"/>
    <dbReference type="KEGG" id="cjo:107324891"/>
    <dbReference type="CTD" id="6197"/>
    <dbReference type="GeneTree" id="ENSGT00940000159370"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032496">
        <property type="term" value="P:response to lipopolysaccharide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002224">
        <property type="term" value="P:toll-like receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd14176">
        <property type="entry name" value="STKc_RSK2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05582">
        <property type="entry name" value="STKc_RSK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000010">
        <property type="entry name" value="Ribosomal protein S6 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000041">
        <property type="entry name" value="Ribosomal protein S6 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000013">
        <property type="entry name" value="Ribosomal protein S6 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000121">
        <property type="entry name" value="Ribosomal protein S6 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016239">
        <property type="entry name" value="Ribosomal_S6_kinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041905">
        <property type="entry name" value="RPS6KA3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041906">
        <property type="entry name" value="RSK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000606">
        <property type="entry name" value="Ribsml_S6_kin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 12 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="68"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="18">
        <location>
            <begin position="328"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="422"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="13"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="539"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="74"/>
            <end position="82"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14 15">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="428"/>
            <end position="436"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14 15">
        <location>
            <position position="451"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR000606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000606-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000606-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005021473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="740" mass="83609" checksum="98962BBA7E0C99AC" modified="2022-01-19" version="1">MPLAQLADPWQKMAVESAAESSTENGQQIVDEPMGEDDINPQNEEEIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEDDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHPFFSKIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAIASDDESQSMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSICKRCVHKASNMEYAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNTVSDTAKDLVSKMLHVDPHQRLTAAQVLSHPWIVHCDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U3W2</accession>
    <name>A0A8C2U3W2_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">RAB3A interacting protein like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">RAB3IL1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the SEC2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015719126.1">
        <property type="nucleotide sequence ID" value="XM_015863640.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U3W2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005030615.1">
        <property type="protein sequence ID" value="ENSCJPP00005022327.1"/>
        <property type="gene ID" value="ENSCJPG00005017813.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107314440"/>
    <dbReference type="KEGG" id="cjo:107314440"/>
    <dbReference type="CTD" id="5866"/>
    <dbReference type="GeneTree" id="ENSGT00940000159102"/>
    <dbReference type="OrthoDB" id="5560525at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070319">
        <property type="term" value="C:Golgi to plasma membrane transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21069">
        <property type="entry name" value="Rab11BD_RAB3IL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.4880:FF:000001">
        <property type="entry name" value="Guanine nucleotide exchange factor for Rab-3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040351">
        <property type="entry name" value="RAB3IL/RAB3IP/Sec2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009449">
        <property type="entry name" value="Sec2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430:SF5">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR FOR RAB-3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430">
        <property type="entry name" value="RABIN3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25555">
        <property type="entry name" value="RAB3A-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06428">
        <property type="entry name" value="Sec2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144284">
        <property type="entry name" value="Sec2 N-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GDP/GTP exchange factor Sec2 N-terminal" evidence="9">
        <location>
            <begin position="50"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="71"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="47"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005022327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="375" mass="42371" checksum="0A43E583FBDCC3D8" modified="2022-01-19" version="1">MALVSQTHFEEDSQEQPAVGYWKPLKPSKGSKEEPETGCQDAGCGDDSQSTEQRNVSRLRSSSVEIREKGSEFLKEELHKAQKELKLKDKECERLSKVREQLEQELEELTASLFEEAHKMVREANTKQAASEKQLKEAWGKIDMLQAEVTALKTLVITSTPSSPNWELHPQLQSPSKAVFRKGHGRNKSTSSAIVTAVSQSATPAPVSRECKEIDSILFAEFQSWKESPTLDKSCSFLDRIYREDVGPCLDFTKQELSELVRVAVEQNTLTIEPVASQMLPVVVSAEDSGGPKKCALSGLPRTCKHRIMLGDSGNYYYISPSCRARITAVCNFFTYIRYIQQGLVRQDVELMYWEVMRLRREMSLAKLGFYPNEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U3W5</accession>
    <name>A0A8C2U3W5_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Phosphoglucomutase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">PGM2</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015717984.1">
        <property type="nucleotide sequence ID" value="XM_015862498.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U3W5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005031607.1">
        <property type="protein sequence ID" value="ENSCJPP00005023073.1"/>
        <property type="gene ID" value="ENSCJPG00005018323.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107313826"/>
    <dbReference type="KEGG" id="cjo:107313826"/>
    <dbReference type="CTD" id="55276"/>
    <dbReference type="GeneTree" id="ENSGT00940000156247"/>
    <dbReference type="OrthoDB" id="8300170at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004614">
        <property type="term" value="F:phosphoglucomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008973">
        <property type="term" value="F:phosphopentomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05799">
        <property type="entry name" value="PGM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000017">
        <property type="entry name" value="glucose 1,6-bisphosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000018">
        <property type="entry name" value="Glucose 1,6-bisphosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000035">
        <property type="entry name" value="Pgm3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45745">
        <property type="entry name" value="PHOSPHOMANNOMUTASE 45A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45745:SF3">
        <property type="entry name" value="PHOSPHOPENTOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="11">
        <location>
            <begin position="52"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="12">
        <location>
            <begin position="224"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="13">
        <location>
            <begin position="365"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005023073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="609" mass="68029" checksum="7ABECB6EA33AB21C" modified="2022-01-19" version="1">MAAHGSAGDAALRREAEQWLQWDKNPKTSAIVKEVLAGGNVGELQKYFGSRMEFGTAGLRAAMGAGISHMNDLTIIQTTQGFCRYLEKNFSDLKKRGVVIGFDARAHLSSGGSSKRFARLAANTFISQGVPVYLFSDITPTPFVPYTVTHLKLCAGIMVTASHNPKQDNGYKVYWENGAQIISHHDKGISQAIEENKEPWPQAWDDKQIDSSVLLHDPYATINKEYFKDIQKQCFHRNINKETNLKFVHTSVHGVGHKFVQLAFKAFDLRPPFAVPEQKDPDPEFPTVKYPNPEEGKGVLTLSFALAEKDGAKIILANDPDADRLAVAEKQESGEWKVFSGNELGALLGWWIFTCWKNQNRDARSIKDVYMLSSTVSSKILRAIALKEGFHFEETLTGFKWMGNRAKQLMDQGKAVLFAFEEAIGYMCCPAVLDKDGVSAAVITAEMASFLATRNLSLSQQLKAVYDEYGFHITKASYFICHDPKVIQQLFDNLRNYDGKDTYPKSCGRFKVSGIRDLTTGYDSSQPDQKAILPTSKSSQMITFTFANGGVATMRTSGTEPKIKYYSELCAPPGNSDIEQLKKELDELVNALEKHFFQPEKNNLQRKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U4F5</accession>
    <name>A0A8C2U4F5_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1</fullName>
            <ecNumber evidence="5">2.4.99.20</ecNumber>
            <ecNumber evidence="4">3.2.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">2'-phospho-ADP-ribosyl cyclase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">2'-phospho-cyclic-ADP-ribose transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">ADP-ribosyl cyclase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Cyclic ADP-ribose hydrolase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">CD38</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>NAD(+) + H2O = ADP-D-ribose + nicotinamide + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16301"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57967"/>
            <dbReference type="EC" id="3.2.2.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ADP-ribosyl cyclase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.20" evidence="5"/>
    <dbReference type="EC" id="3.2.2.6" evidence="4"/>
    <dbReference type="RefSeq" id="XP_015718173.1">
        <property type="nucleotide sequence ID" value="XM_015862687.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032300077.1">
        <property type="nucleotide sequence ID" value="XM_032444186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U4F5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005031786.1">
        <property type="protein sequence ID" value="ENSCJPP00005023170.1"/>
        <property type="gene ID" value="ENSCJPG00005018410.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107313951"/>
    <dbReference type="KEGG" id="cjo:107313951"/>
    <dbReference type="CTD" id="952"/>
    <dbReference type="GeneTree" id="ENSGT00390000017291"/>
    <dbReference type="OrthoDB" id="10028716at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061809">
        <property type="term" value="F:NAD+ nucleosidase activity, cyclic ADP-ribose generating"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016849">
        <property type="term" value="F:phosphorus-oxygen lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042100">
        <property type="term" value="P:B cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050853">
        <property type="term" value="P:B cell receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030890">
        <property type="term" value="P:positive regulation of B cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009410">
        <property type="term" value="P:response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd04759">
        <property type="entry name" value="Rib_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.82.10">
        <property type="entry name" value="ADP Ribosyl Cyclase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003193">
        <property type="entry name" value="ADP-ribosyl_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10912">
        <property type="entry name" value="ADP-RIBOSYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10912:SF5">
        <property type="entry name" value="ADP-RIBOSYL CYCLASE_CYCLIC ADP-RIBOSE HYDROLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02267">
        <property type="entry name" value="Rib_hydrolayse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52309">
        <property type="entry name" value="N-(deoxy)ribosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00030272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00030418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00031355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00031840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005023170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="308" mass="34424" checksum="52F7E83152411AE3" modified="2022-01-19" version="1">MPSQRGSERRRQRCVLLAGIAFLLIALVLAAVLASMLTGSKEEKSPELLRWQGRGTTRNLREIVLGRCYSYLAEGHVELGDRDCLKIWESLKAAFIHKNPCNSTTEDYQPLMELASHPVPCNKSLFWSRTYDLVHLYSKSNRQFLTLEDTFLGYMLDGLSWCGDPSAPGINYESCPKWSECEGSSVSVFWKMASKMFAEAACGVVHVMLNGSIEAGAFRSSSIFGSVEVFNLNPDKVSELRIWLMHDIGGPQSDSCSGHSIMKLRSILEKRNVKITCEDNYRPVQLLQCAHNPDHPDCSFCTSSTEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U4R4</accession>
    <name>A0A8C2U4R4_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]</fullName>
            <ecNumber evidence="9">1.3.1.124</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">2,4-dienoyl-CoA reductase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">DECR2</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + NADPH + H(+) = (3E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:44920"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:77559"/>
            <dbReference type="ChEBI" id="CHEBI:84791"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a (2E,4E)-dienoyl-CoA + NADPH + H(+) = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:45912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85101"/>
            <dbReference type="ChEBI" id="CHEBI:85493"/>
            <dbReference type="EC" id="1.3.1.124"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a (2E,4Z)-dienoyl-CoA + NADPH + H(+) = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:61892"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85099"/>
            <dbReference type="ChEBI" id="CHEBI:85493"/>
            <dbReference type="EC" id="1.3.1.124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer, dimer and oligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2,4-dienoyl-CoA reductase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.124" evidence="9"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2U4R4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005029067.1">
        <property type="protein sequence ID" value="ENSCJPP00005021135.1"/>
        <property type="gene ID" value="ENSCJPG00005016923.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153801"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008670">
        <property type="term" value="F:2,4-dienoyl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019166">
        <property type="term" value="F:trans-2-enoyl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006636">
        <property type="term" value="P:unsaturated fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd05369">
        <property type="entry name" value="TER_DECR_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000477">
        <property type="entry name" value="Peroxisomal 2,4-dienoyl-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045017">
        <property type="entry name" value="DECR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43296">
        <property type="entry name" value="PEROXISOMAL 2,4-DIENOYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43296:SF2">
        <property type="entry name" value="PEROXISOMAL 2,4-DIENOYL-COA REDUCTASE [(3E)-ENOYL-COA-PRODUCING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00026221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005021135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="293" mass="31165" checksum="35D141A25128AC81" modified="2022-01-19" version="1">IASQAPADVESDECLAEYRHLYSPDILQGRVAFITGGGSGIGFRIAEVFMRHGCRTVIAGRNQQRVAEASKKLVAATGQQCLPLSVDVRQPQTIMAAVDETLKQFKQIDILVNGAAGNFLCPASALSFNAFKTVMDIDTLGTFNTSKVLFEKYFRDHGGVIVNITATLSYRGQALQVHAGSAKAAIDAMTRHLAVEWGPNNIRVNSLAPGPITGTEGFRRLGGKFAQDSNQFDTIPLQRAGNKTEIAHSALYLASPLSSYVTGTTLVVDGGSWLTSANSFSALLGIASSSAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U549</accession>
    <name>A0A8C2U549_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Insulin-like growth factor 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Insulin-like growth factor II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">IGF2</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the insulin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015719328.1">
        <property type="nucleotide sequence ID" value="XM_015863842.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U549"/>
    <dbReference type="Ensembl" id="ENSCJPT00005032094.1">
        <property type="protein sequence ID" value="ENSCJPP00005023418.1"/>
        <property type="gene ID" value="ENSCJPG00005018582.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107314538"/>
    <dbReference type="KEGG" id="cjo:107314538"/>
    <dbReference type="CTD" id="3481"/>
    <dbReference type="GeneTree" id="ENSGT00940000160745"/>
    <dbReference type="OrthoDB" id="9449995at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005158">
        <property type="term" value="F:insulin receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005159">
        <property type="term" value="F:insulin-like growth factor receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030297">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031017">
        <property type="term" value="P:exocrine pancreas development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008286">
        <property type="term" value="P:insulin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048009">
        <property type="term" value="P:insulin-like growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051148">
        <property type="term" value="P:negative regulation of muscle cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001649">
        <property type="term" value="P:osteoblast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042104">
        <property type="term" value="P:positive regulation of activated T cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045725">
        <property type="term" value="P:positive regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046628">
        <property type="term" value="P:positive regulation of insulin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045840">
        <property type="term" value="P:positive regulation of mitotic nuclear division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040018">
        <property type="term" value="P:positive regulation of multicellular organism growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046622">
        <property type="term" value="P:positive regulation of organ growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051897">
        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048633">
        <property type="term" value="P:positive regulation of skeletal muscle tissue growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905564">
        <property type="term" value="P:positive regulation of vascular endothelial cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051146">
        <property type="term" value="P:striated muscle cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd04368">
        <property type="entry name" value="IlGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.100.10:FF:000002">
        <property type="entry name" value="Insulin-like growth factor II preproprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.100.10">
        <property type="entry name" value="Insulin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022350">
        <property type="entry name" value="IGF-1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022334">
        <property type="entry name" value="IGF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013576">
        <property type="entry name" value="IGF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022352">
        <property type="entry name" value="Ins/IGF/rlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016179">
        <property type="entry name" value="Insulin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036438">
        <property type="entry name" value="Insulin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022353">
        <property type="entry name" value="Insulin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46886">
        <property type="entry name" value="INSULIN-LIKE GROWTH FACTOR II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46886:SF1">
        <property type="entry name" value="INSULIN-LIKE GROWTH FACTOR II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08365">
        <property type="entry name" value="IGF2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00049">
        <property type="entry name" value="Insulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02002">
        <property type="entry name" value="INSLNLIKEGF"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02006">
        <property type="entry name" value="INSLNLIKEGF2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00276">
        <property type="entry name" value="INSULINFAMLY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00078">
        <property type="entry name" value="IlGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56994">
        <property type="entry name" value="Insulin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00262">
        <property type="entry name" value="INSULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0339">Growth factor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Insulin-like" evidence="12">
        <location>
            <begin position="66"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="199"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="69"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="81"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="107"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR622350-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005023418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="224" mass="24660" checksum="9D3C9CD966292057" modified="2022-01-19" version="1">MASAGAHTDERCRQPAFLPGPPPTEVESGSGSAKVQRMCAARQMLLLLLAFLAYALDSAAAYGTAETLCGGELVDTLQFVCGDRGFYFSRPVGRNNRRINRGIVEECCFRSCDLALLETYCAKSVKSERDLSATSLVGLPALNKESFQKPSHAKYSKYNVWQKKSSQRLQREVPGILRARRYRWQAEGLQAAEEARAMHRPLISLPSQRPPAPQASPEATGPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U6N3</accession>
    <name>A0A8C2U6N3_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Golgi SNAP receptor complex member 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">27 kDa Golgi SNARE protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Membrin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">GOSR2</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11 17">Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Golgi apparatus</location>
            <location evidence="12">cis-Golgi network membrane</location>
            <topology evidence="12">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13 17">Belongs to the GOSR2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015740972.1">
        <property type="nucleotide sequence ID" value="XM_015885486.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U6N3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005032833.1">
        <property type="protein sequence ID" value="ENSCJPP00005024042.1"/>
        <property type="gene ID" value="ENSCJPG00005018999.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107325027"/>
    <dbReference type="KEGG" id="cjo:107325027"/>
    <dbReference type="CTD" id="9570"/>
    <dbReference type="GeneTree" id="ENSGT00950000183192"/>
    <dbReference type="OrthoDB" id="158360at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15863">
        <property type="entry name" value="SNARE_GS27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000044">
        <property type="entry name" value="Golgi SNAP receptor complex member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027027">
        <property type="entry name" value="GOSR2/Membrin/Bos1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230:SF1">
        <property type="entry name" value="GOLGI SNAP RECEPTOR COMPLEX MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230">
        <property type="entry name" value="VESICLE TRANSPORT V-SNARE PROTEIN VTI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028865">
        <property type="entry name" value="Membrin-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 17 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 17" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 17" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00072070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00076985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00080151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR028865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005024042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="212" mass="24767" checksum="71F78CEA4FE3FE38" modified="2022-01-19" version="1">MEALYHQTNKQVHEVQSYMGRLETSDKESVHLVENEIQARIDKVFSDLERLEILSSKEPPNKRQNAKLRVDQLKYDVQHLQTALRNFQHRRYIREQQERQREELLARTFTTNDSDTTIPIDETLQFNESLQNAHRGMDDLIGSGTNILQGLRDQRLTLKGTQKKILDVANTLGLSNTVMRLIEKRAFQDKYFMIGGMIVTCLVMFLVVQYLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U877</accession>
    <name>A0A8C2U877_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2U877"/>
    <dbReference type="Ensembl" id="ENSCJPT00005032824.1">
        <property type="protein sequence ID" value="ENSCJPP00005024033.1"/>
        <property type="gene ID" value="ENSCJPG00005018991.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162998"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002376">
        <property type="term" value="P:immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009617">
        <property type="term" value="P:response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052051">
        <property type="entry name" value="TCR_complex_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19433:SF111">
        <property type="entry name" value="T CELL RECEPTOR ALPHA VARIABLE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19433">
        <property type="entry name" value="T-CELL RECEPTOR ALPHA CHAIN V REGION-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0391">Immunity</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="106"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005024033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="159" mass="17311" checksum="37250555FCE00F92" modified="2025-10-08" version="2">MTQVERIFYGNLAQPLVETSEDTGINITCSHPSIQSNENIHWYRQLPDRGPVFIVSVFKDSKEVPNPVGRLSVSADRRSSALWLARPRLGDAAVYYCAVGTRGEEPGLRPDTNRFGRPGSTVPSGPAGGAACRANKLHSDQDAPPCAIGRKEQDTHCSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U944</accession>
    <name>A0A8C2U944_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP-dependent RNA helicase DHX15</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">DEAH box protein 15</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">DHX15</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. Identified in the Intron Large spliceosome complex (IL, also named intron lariat spliceosome), a post-mRNA release spliceosomal complex containing the excised intron, U2, U5 and U6 snRNPs, and splicing factors; the association may be transient. The IL complex exists in two distinct conformations, one with the DHX15 (ILS2) and one without (ILS1). Interacts with TFIP11 (via G-patch domain); indicative for a recruitment to the IL complex. Interacts with SSB/La. Interacts with GPATCH2 (via G-patch domain); promoting the RNA helicase activity. Interacts with NKRF (via G-patch domain); promoting the RNA helicase activity. Interacts with NLRP6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="RefSeq" id="XP_015718132.1">
        <property type="nucleotide sequence ID" value="XM_015862646.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U944"/>
    <dbReference type="Ensembl" id="ENSCJPT00005031706.1">
        <property type="protein sequence ID" value="ENSCJPP00005023130.1"/>
        <property type="gene ID" value="ENSCJPG00005018376.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107313929"/>
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            <taxon>Galliformes</taxon>
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            <taxon>Perdicinae</taxon>
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                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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        <scope>IDENTIFICATION</scope>
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        </source>
    </evidence>
    <sequence length="1523" mass="167856" checksum="BEACC292C9F88243" modified="2022-01-19" version="1">MQGNKKHTEGQSDSSSIGSLLDDTDREVSSLTDRAFKSLCVAELEDSYNEPDLAISPDFTHQFSAKFHPGALNHAVKLTASCNKLAARNNEHAIWASTFQQLPKCAPEEKKSAKNNTLGTERRRLNLPVPGLRNNKHVSKVSSLIKTFDKTANQGSGDSLTASKQPIKNSFQRCKLNHGNDMTCWDNTAILNIHKELSGFSEDRQDSHHVSGKQEPQKIPNKIDLSYCGSDGCYPVLIEMSKVAKSNFSRSSKNALKNKNLKVNEPAKKGNFLHSENSAFESWNVHHKKLSEKEEFVDPITKKESLAYLEEAPFIKGSHASELKLPPVKATVTKKQKKDFQMEPIPPETAFSVPLPAVFVPQGPLPSGTDFPAALPPVPPPRIHMYQDPSQPPPVPQSLSLPAPPRPPTPPIHEAPPIPPLPLPAQPSPHAMSQTSISPQSMSHRMVSPSSSSQAPVPPPRVLLATLTKEEAISPPWRRLRATKGASERRQTSEEFPVSNETCLLSEKASGAKPDQDVIPLIKQANSPGSVSPIFNITELLTPIIPPKQEMDPMESEMIPLTPPPTESVSEKDDEESVFSDYRSRDSYKSKASSLLFNLKDVRKRVKTIYTPSPLLRVLENRNKARESIQENLQEKNNMKMAEKDELSDITSALSESVHEKDNKTDLAGHFTDNYLTLSSPQTTADLLFHQTGDNLQQHHSTHEDLIKNTRGNEGHSLLGHQCEEPNLRKSLPYPAMKLYSKDDADRTPGQPLQNSSFRAEEKADELNENVAFKTPSSQLSPAEDVPYSNIQTNMVVTGNEEQGKRSPSSSEQSFISTVEQPFHEEPLSTEPLMKKESHEESQRTKAEMSEESKKSHEERQNAVGEDKLQYYACVSSGTGAAERKEGAVTENEQKSMMKEKLRQEKKEEANGKDSASDSIKDTPTTRLEEPQTRPSSSSAKPRLFMIKDNTFRSPQVIRAVKMPLFRSFSLDDTVSSSYKEMEGRFATPAAHSKQPQDVLHAPEQGWSASMHRGQQDVREGAADRGRDASGSGNTSATLDPNLLEDTESFLLGKLMEKDEETCALLNEVGKMNEESICRDKEKPQIRKAGHSLTQPNLGLENDQAQNSPSYPTERKVNYFKNQHLFNRRGGSCAKKIITTETISPVTESIPEDHTYLSASHEALEDMLDVEDTQVLLDSLECSAVTSPRSGSTMHSLVVSLPSDKTTISSLGETEGAINPALLNMALKSQADTSAEEILNPTQRHLLLDPAGEAERRGLGERGAGKPPAVPPKTEKALRRAKKLASRRKKIEEQQKKHQTEHTDAVGRKVSQSGHTLASPSPLGYSIHPAPHSTLTPPETSIRRLSGASAVSPSPSLTQRKLLQDPDSGQYYVVDLPAEVNLKTFYDPETGKYVQVSVPSSEGNVYQPSPSEIRSSPYSSYPRALPLPASSVAVLRSPSQLSESTWLMPTTQGELEELPKDGQQEYRYTGDVDTQPCIELASQSCSQDTEETHICLGKDMSPTPNTALVSLTNLDNFSAEGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U9T0</accession>
    <name>A0A8C2U9T0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U9T0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005032822.1">
        <property type="protein sequence ID" value="ENSCJPP00005024031.1"/>
        <property type="gene ID" value="ENSCJPG00005018988.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000235023"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042101">
        <property type="term" value="C:T cell receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042605">
        <property type="term" value="F:peptide antigen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051006">
        <property type="entry name" value="TCR_variable_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19343:SF26">
        <property type="entry name" value="T CELL RECEPTOR ALPHA VARIABLE 1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19343">
        <property type="entry name" value="T CELL RECEPTOR ALPHA VARIABLE 1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="2" id="KW-0391">Immunity</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-1279">T cell receptor</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034418780" description="Ig-like domain-containing protein" evidence="7">
        <location>
            <begin position="24"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="19"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005024031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="128" mass="14420" checksum="D2AE22F4521D062E" modified="2022-01-19" version="1">MLAGWSLPCRAPYLCFLLPDAMGQTTVTQQERQVTVEEGNTFQISCTYQTSNFDAFLWYQQKEGQAPQLVTYQPTAGTKQNGRFTTWLNTTAKYSLLQLAEVELSDSALYLCAVKDTLVHTSSLHQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U9V1</accession>
    <name>A0A8C2U9V1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BBSome-interacting protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U9V1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005034713.1">
        <property type="protein sequence ID" value="ENSCJPP00005025536.1"/>
        <property type="gene ID" value="ENSCJPG00005020033.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000235307"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034464">
        <property type="term" value="C:BBSome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097500">
        <property type="term" value="P:receptor localization to non-motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028233">
        <property type="entry name" value="BBIP10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28596">
        <property type="entry name" value="BBSOME-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28596:SF1">
        <property type="entry name" value="BBSOME-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14777">
        <property type="entry name" value="BBIP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005025536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="87" mass="9245" checksum="FE44D1FCA7223477" modified="2022-01-19" version="1">LSRTKTESPYITGKLTTSVGKGTIREVLPKQGPLAAEDTAGMVLCKPKVLPLKSVSLEKLEQLQRAAMEAMEASRPPEGSAGSQPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UAM3</accession>
    <name>A0A8C2UAM3_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Phosphatidylinositol glycan anchor biosynthesis class U</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PIGU</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGU family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2UAM3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005033973.1">
        <property type="protein sequence ID" value="ENSCJPP00005024945.1"/>
        <property type="gene ID" value="ENSCJPG00005019631.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000014941"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034235">
        <property type="term" value="F:GPI anchor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003923">
        <property type="term" value="F:GPI-anchor transamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046425">
        <property type="term" value="P:regulation of receptor signaling pathway via JAK-STAT"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009600">
        <property type="entry name" value="PIG-U"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13121">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13121:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN ANCHOR BIOSYNTHESIS CLASS U PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06728">
        <property type="entry name" value="PIG-U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034199276" evidence="10">
        <location>
            <begin position="18"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="159"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="351"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005024945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="401" mass="45823" checksum="9CE46CFC176D3429" modified="2022-01-19" version="1">MAAPLVLAVLAAVTVRAALYRSSLAAFIAERVEVASPLNAWKRGEAPHFSSITDVLTAVALYLAIQDYNKVVFKKQKLLIELDKYAPDVAELIRTPMEMHYIPLKVALVYLLNPYTVMSCVAKSTCAISNTVIAFFILATIRGSAFLSAVFLALATYQSLYPITLFAPALLYLLQRQFIPIKPKSKSFWLFTMQYAALYLCSLVVVICLSFFLLNSWDFIPSVYGFILSVPDLTPNIGLFWYFFAEMFEHFSLFFVCVFQINVFFYTIPLAVKLKEHPVFFMFVQLAIISIFKSYPTVGDVALYMAFLPVWSHLYRFLRNIFILSCMLIACSLLFPVLWHLWIFAGSANSNFYYAITLTFNIGQILLISDYFYAFLRREYYLTHGLHLTRQDGTEAMLVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UAY2</accession>
    <name>A0A8C2UAY2_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Retinol binding protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">RBP4</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 10">Belongs to the calycin superfamily. Lipocalin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015722631.1">
        <property type="nucleotide sequence ID" value="XM_015867145.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UAY2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005033154.1">
        <property type="protein sequence ID" value="ENSCJPP00005024310.1"/>
        <property type="gene ID" value="ENSCJPG00005019183.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107316059"/>
    <dbReference type="KEGG" id="cjo:107316059"/>
    <dbReference type="CTD" id="5950"/>
    <dbReference type="GeneTree" id="ENSGT00510000047107"/>
    <dbReference type="OrthoDB" id="9923952at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140104">
        <property type="term" value="F:molecular carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019841">
        <property type="term" value="F:retinol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034632">
        <property type="term" value="F:retinol transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048738">
        <property type="term" value="P:cardiac muscle tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050908">
        <property type="term" value="P:detection of light stimulus involved in visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048562">
        <property type="term" value="P:embryonic organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060059">
        <property type="term" value="P:embryonic retina morphogenesis in camera-type eye"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048706">
        <property type="term" value="P:embryonic skeletal system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048807">
        <property type="term" value="P:female genitalia morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042593">
        <property type="term" value="P:glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060347">
        <property type="term" value="P:heart trabecula formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030324">
        <property type="term" value="P:lung development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030277">
        <property type="term" value="P:maintenance of gastrointestinal epithelium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008584">
        <property type="term" value="P:male gonad development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060044">
        <property type="term" value="P:negative regulation of cardiac muscle cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007603">
        <property type="term" value="P:phototransduction, visible light"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002639">
        <property type="term" value="P:positive regulation of immunoglobulin production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032024">
        <property type="term" value="P:positive regulation of insulin secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032868">
        <property type="term" value="P:response to insulin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032526">
        <property type="term" value="P:response to retinoic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042574">
        <property type="term" value="P:retinal metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042572">
        <property type="term" value="P:retinol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060068">
        <property type="term" value="P:vagina development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071939">
        <property type="term" value="P:vitamin A import into cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00743">
        <property type="entry name" value="lipocalin_RBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.128.20:FF:000004">
        <property type="entry name" value="Retinol-binding protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022271">
        <property type="entry name" value="Lipocalin_ApoD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022272">
        <property type="entry name" value="Lipocalin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000566">
        <property type="entry name" value="Lipocln_cytosolic_FA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002449">
        <property type="entry name" value="Retinol-bd/Purpurin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11873">
        <property type="entry name" value="RETINOL-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11873:SF2">
        <property type="entry name" value="RETINOL-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00061">
        <property type="entry name" value="Lipocalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036893">
        <property type="entry name" value="Lipocalin_ApoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500204">
        <property type="entry name" value="RBP_purpurin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00179">
        <property type="entry name" value="LIPOCALIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01174">
        <property type="entry name" value="RETINOLBNDNG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00213">
        <property type="entry name" value="LIPOCALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0683">Retinol-binding</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034355456" evidence="7">
        <location>
            <begin position="26"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Lipocalin/cytosolic fatty-acid binding" evidence="11">
        <location>
            <begin position="46"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="29"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="95"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR036893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR036893-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR036893-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005024310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="200" mass="23071" checksum="9ECFB768C09AE8D2" modified="2022-01-19" version="1">MQDRMAYRRRALLLLALAFLGSSMAERDCRVSSFKVKENFDKNRYSGTWYAMAKKDPEGLFLQDNVVAQFTVDENGQMSATAKGRVRLFNNWDVCADMIGSFTDTEDPAKFKMKYWGVASFLQKGNDDHWVVDTDYDTYALHYSCRELNEDGTCADSYSFVFSRDPKGLPPEAQKIVRQRQIDLCLDRKYRVIVHNGFCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UBU5</accession>
    <name>A0A8C2UBU5_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 2 subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Eukaryotic translation initiation factor 2 subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">EIF2S2</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-beta/eIF-5 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015736838.1">
        <property type="nucleotide sequence ID" value="XM_015881352.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UBU5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005036012.1">
        <property type="protein sequence ID" value="ENSCJPP00005026569.1"/>
        <property type="gene ID" value="ENSCJPG00005020665.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107322845"/>
    <dbReference type="KEGG" id="cjo:107322845"/>
    <dbReference type="CTD" id="8894"/>
    <dbReference type="GeneTree" id="ENSGT00390000001804"/>
    <dbReference type="OrthoDB" id="10255414at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002176">
        <property type="term" value="P:male germ cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008584">
        <property type="term" value="P:male gonad development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.170:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045196">
        <property type="entry name" value="IF2/IF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002735">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016189">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016190">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_Zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001:SF3">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01873">
        <property type="entry name" value="eIF-5_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00653">
        <property type="entry name" value="eIF2B_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100966">
        <property type="entry name" value="Translation initiation factor 2 beta, aIF2beta, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75689">
        <property type="entry name" value="Zinc-binding domain of translation initiation factor 2 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation initiation factor IF2/IF5" evidence="7">
        <location>
            <begin position="200"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005026569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="334" mass="38451" checksum="9EFC088C73749D90" modified="2022-01-19" version="1">MSGDEMIFDPTMSKKKKRKKKPFMLDEEGADTQTEETQQSETKEVEPEPTEDKDVEADEEDSRKKDATDDLDDLNFFNQKKKKKKPKKIFDIDEAEEGVKELKIEGDVPEVVEPEDDLDIMLGNKKKKKKFVKFPDEDEVLEKDEAFEDEDSKKDDGISFSLQSGPAWAGSERDYTYDELLNRVFNIMREKNPDMVAGEKRKFVMKPPQVVRVGTKKTSFVNFTDICKLLHRQPKHLLAFLLAELGTSGSIDGNNQLVIKGRFQQKQIENVLRRYIKEYVTCHTCRSPDTILQKDTRLYFLQCETCHSRCSVASIKTGFQAVTGKRAQLRAKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UE83</accession>
    <name>A0A8C2UE83_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="29">Solute carrier family 25 member 30</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="29" type="primary">SLC25A30</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="29" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="29" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(2R,3R)-tartrate(in) + sulfate(out) = (2R,3R)-tartrate(out) + sulfate(in)</text>
            <dbReference type="Rhea" id="RHEA:73403"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:30924"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(3R)-citramalate(in) + sulfate(out) = (3R)-citramalate(out) + sulfate(in)</text>
            <dbReference type="Rhea" id="RHEA:73227"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:30934"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(3S)-citramalate(in) + sulfate(out) = (3S)-citramalate(out) + sulfate(in)</text>
            <dbReference type="Rhea" id="RHEA:73223"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:30936"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>(S)-malate(in) + sulfate(out) = (S)-malate(out) + sulfate(in)</text>
            <dbReference type="Rhea" id="RHEA:71615"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>(S)-malate(out) = (S)-malate(in)</text>
            <dbReference type="Rhea" id="RHEA:74555"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>(S,S)-tartrate(in) + sulfate(out) = (S,S)-tartrate(out) + sulfate(in)</text>
            <dbReference type="Rhea" id="RHEA:73407"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:30927"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>D-aspartate(in) + sulfate(out) = D-aspartate(out) + sulfate(in)</text>
            <dbReference type="Rhea" id="RHEA:73399"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:29990"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)</text>
            <dbReference type="Rhea" id="RHEA:73395"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>maleate(in) + sulfate(out) = maleate(out) + sulfate(in)</text>
            <dbReference type="Rhea" id="RHEA:73199"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:30780"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>malonate(in) + sulfate(out) = malonate(out) + sulfate(in)</text>
            <dbReference type="Rhea" id="RHEA:73195"/>
            <dbReference type="ChEBI" id="CHEBI:15792"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>oxalate(in) + sulfate(out) = oxalate(out) + sulfate(in)</text>
            <dbReference type="Rhea" id="RHEA:72275"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:30623"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>phosphate(in) = phosphate(out)</text>
            <dbReference type="Rhea" id="RHEA:32823"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>sulfate(in) = sulfate(out)</text>
            <dbReference type="Rhea" id="RHEA:34983"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>sulfate(out) + phosphate(in) = sulfate(in) + phosphate(out)</text>
            <dbReference type="Rhea" id="RHEA:71631"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>sulfate(out) + succinate(in) = sulfate(in) + succinate(out)</text>
            <dbReference type="Rhea" id="RHEA:73411"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>sulfite(in) + sulfate(out) = sulfite(out) + sulfate(in)</text>
            <dbReference type="Rhea" id="RHEA:73207"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>thiosulfate(in) + sulfate(out) = thiosulfate(out) + sulfate(in)</text>
            <dbReference type="Rhea" id="RHEA:73215"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:33542"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 28">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015707242.1">
        <property type="nucleotide sequence ID" value="XM_015851756.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032297981.1">
        <property type="nucleotide sequence ID" value="XM_032442090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UE83"/>
    <dbReference type="Ensembl" id="ENSCJPT00005034173.1">
        <property type="protein sequence ID" value="ENSCJPP00005025085.1"/>
        <property type="gene ID" value="ENSCJPG00005019734.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107308129"/>
    <dbReference type="KEGG" id="cjo:107308129"/>
    <dbReference type="CTD" id="253512"/>
    <dbReference type="GeneTree" id="ENSGT00940000158961"/>
    <dbReference type="OrthoDB" id="756301at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005452">
        <property type="term" value="F:solute:inorganic anion antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000006">
        <property type="entry name" value="brain mitochondrial carrier protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00784">
        <property type="entry name" value="MTUNCOUPLING"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 27" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 27 28" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 28" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="27">
        <location>
            <begin position="7"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="27">
        <location>
            <begin position="104"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="27">
        <location>
            <begin position="198"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00035765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00035807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00035907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00035985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00036015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00036130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00036479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00036514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00036586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00036616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00036751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00036759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00037004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00050259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00052073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00052829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00052901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005025085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="291" mass="32504" checksum="F7A8CDCDEB7281A1" modified="2022-01-19" version="1">MSALSWKPFLYGGLASITAECGTFPIDLTKTRLQVQGQVNDAKYKEIRYRGMMHALVRIFREEGLKALYSGIAPAMLRQASYGTIKIGTYQSLKRMFVEHPEDETLMINVLCGILSGVISSSIANPTDVLKIRMQAQGSVIQGGMMCNFIQIYQNEGTKGLWKGVSLTAQRAALVVGVELPVYDFTKKQIIMSGYMGDTVYTHFLSSFTCGLAGALASNPVDVVRTRMMNQASQPNGGHSNYKGTLDCLLQTWKNEGFFALYKGFWPNWLRLGPWNIIFFVTYEQLKKLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UIE6</accession>
    <name>A0A8C2UIE6_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="19 23">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="19 23">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="primary">UCHL5</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 19 22 23">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 19 22 23">Belongs to the peptidase C12 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="19 23"/>
    <dbReference type="RefSeq" id="XP_015724925.1">
        <property type="nucleotide sequence ID" value="XM_015869439.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UIE6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005036977.1">
        <property type="protein sequence ID" value="ENSCJPP00005027336.1"/>
        <property type="gene ID" value="ENSCJPG00005021205.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107317133"/>
    <dbReference type="KEGG" id="cjo:107317133"/>
    <dbReference type="CTD" id="51377"/>
    <dbReference type="GeneTree" id="ENSGT00940000155195"/>
    <dbReference type="OrthoDB" id="1924260at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048853">
        <property type="term" value="P:forebrain morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021670">
        <property type="term" value="P:lateral ventricle development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030901">
        <property type="term" value="P:midbrain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032435">
        <property type="term" value="P:negative regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045739">
        <property type="term" value="P:positive regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045880">
        <property type="term" value="P:positive regulation of smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904507">
        <property type="term" value="P:positive regulation of telomere maintenance in response to DNA damage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060382">
        <property type="term" value="P:regulation of DNA strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045995">
        <property type="term" value="P:regulation of embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02255">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.532.10:FF:000001">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.860:FF:000009">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase isozyme L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017390">
        <property type="entry name" value="Ubiquitinyl_hydrolase_UCH37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033837">
        <property type="entry name" value="UCH37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041507">
        <property type="entry name" value="UCH_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF16">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE ISOZYME L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18031">
        <property type="entry name" value="UCH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038120">
        <property type="entry name" value="Ubiquitinyl_hydrolase_UCH37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00707">
        <property type="entry name" value="UBCTHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52049">
        <property type="entry name" value="ULD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="24" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="15" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9 19 22" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6 19 22" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-0647">Proteasome</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 19 22" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="14" id="KW-0804">Transcription</keyword>
    <keyword evidence="13" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8 19 22" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="25">
        <location>
            <begin position="9"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="24">
        <location>
            <begin position="223"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="20 22">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="20 22">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="22">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="21 22">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00054164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRNR" id="PIRNR038120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR038120-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR038120-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="RuleBase" id="RU361215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005027336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="331" mass="37819" checksum="D169183280F1A8E5" modified="2022-01-19" version="1">MAGGSSAGEWCLMESDPGVFTELIKGFGCRGAQVEEIWSLEPENFEKLKPVHGLIFLFKWQPGEEPAGSVVQDSRLDTIFFAKQVINNACATQAIVSVLLNCAHQDIRLGETLSEFKEFSQSFDAAMKGLALSNSEVIRQVHNSFARQQMFEFDAKSSAKEEDAFHFVSYVPVNGRLYELDGLREGPIDLGSCNQDDWISAVRPVIEKRIQKYSEGEIRFNLMAIVSDRKMIYEQRIAELQRQLAEEEPMDTDQSSNMLSSIQSEVAKYQMLIEEENQKLKRYKIENIRRKHNYLPFIMELLKTLAEHQQLIPLVEKAKEKQNAKKVQEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y5D0</accession>
    <name>A0A8C2Y5D0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">TUBA1B</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 14">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y5D0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005002887.1">
        <property type="protein sequence ID" value="ENSCJPP00005001704.1"/>
        <property type="gene ID" value="ENSCJPG00005001751.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182825"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome LGE22C19W28_E50C23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071353">
        <property type="term" value="P:cellular response to interleukin-4"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000005">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000007">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11 14" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="16">
        <location>
            <begin position="14"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="17">
        <location>
            <begin position="197"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005001704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="400" mass="44453" checksum="BEA4FB2FF533E6F3" modified="2022-01-19" version="1">MPSDKTIGGGDDSFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLDRIRKLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEPSDCAFMRPTYTNLNRPHQPESVSSITVHLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDMAALEKDYEEVGVDSVEGEGEEEGEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y5J6</accession>
    <name>A0A8C2Y5J6_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">POP7 homolog, ribonuclease P/MRP subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">POP7</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histone-like Alba family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y5J6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005003793.1">
        <property type="protein sequence ID" value="ENSCJPP00005002125.1"/>
        <property type="gene ID" value="ENSCJPG00005002287.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00990000212021"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036882">
        <property type="entry name" value="Alba-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014612">
        <property type="entry name" value="Pop7/Rpp20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15314">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15314:SF1">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82704">
        <property type="entry name" value="AlbA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005002125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="129" mass="13628" checksum="88FCAFCD6F99EE83" modified="2022-01-19" version="1">MSSSHGGAAPTEDPQAQPPPHHHQHHQHRRRRGSAPRPPCAPPGSGTDVFVSMRTDFRAHGGGGPEIRLHGLGLAVTRAINLALQLQAASPGALRLHASTSSDPPDGAAMRPRHNSAIHIRVCREAPCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y6S1</accession>
    <name>A0A8C2Y6S1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine hydroxymethyltransferase</fullName>
            <ecNumber evidence="8">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">SHMT2</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Interconversion of serine and glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the SHMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y6S1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005007703.1">
        <property type="protein sequence ID" value="ENSCJPP00005004636.1"/>
        <property type="gene ID" value="ENSCJPG00005004556.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000002762"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome LGE22C19W28_E50C23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070552">
        <property type="term" value="C:BRISC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006231">
        <property type="term" value="P:dTMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015943">
        <property type="term" value="P:formate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051289">
        <property type="term" value="P:protein homotetramerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070536">
        <property type="term" value="P:protein K63-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070129">
        <property type="term" value="P:regulation of mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002082">
        <property type="term" value="P:regulation of oxidative phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034340">
        <property type="term" value="P:response to type I interferon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000097">
        <property type="entry name" value="Serine hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049943">
        <property type="entry name" value="Ser_HO-MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680:SF28">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Serine hydroxymethyltransferase-like" evidence="10">
        <location>
            <begin position="48"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Serine hydroxymethyltransferase-like" evidence="10">
        <location>
            <begin position="346"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="452"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="453"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005004636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="479" mass="51896" checksum="BEDCE4B2042D521F" modified="2022-01-19" version="1">SWPLPPLWGGPGGRLRSVPCFWRSQHGAAVAAPGHATTPPGWTGQESLADSDPEVWGLVQKEKDRQCRGLELIASENFCSRAALEALGSCLNNKYSRGLHPPPNRYYGGAEVVDQLELLCEQRALDAFDLDPELWGVNVQPYSGSPANFAAYTAVLRPHERLMGLDLPDGGHLTHGFMTDKKKISATSVFFESMPYKLDPLSGLIDYPQLEVTARLFRPRIIIAGTSAYARLIDYGRIKKVCDEVRAFLLADMAHISGLVAAKVIPSPFEHADLVTSTTHKTLRGARSGLIFYRKGVRWVDRQTGRQTLYDLEDKINFAVFPSLQGGPHNHAIAAVAVALKQPPPLFTGGTDNHLVLVDLRPKGIDGARAERVLELVSITANKNTCPGDRSALTPGGLRLGTPALTSRGFGEEDFHKVVEFIDEGIALALDVKSKTTLENFHSFLLAGHGRDPAAPGRAAASASRPSPGPSPMPGFTDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y785</accession>
    <name>A0A8C2Y785_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">MAS1 proto-onco, G protein-coupled receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">MAS1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015713514.1">
        <property type="nucleotide sequence ID" value="XM_015858028.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y785"/>
    <dbReference type="Ensembl" id="ENSCJPT00005009018.1">
        <property type="protein sequence ID" value="ENSCJPP00005005577.1"/>
        <property type="gene ID" value="ENSCJPG00005005311.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107311506"/>
    <dbReference type="KEGG" id="cjo:107311506"/>
    <dbReference type="CTD" id="4142"/>
    <dbReference type="GeneTree" id="ENSGT01030000234639"/>
    <dbReference type="OrthoDB" id="6091802at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001595">
        <property type="term" value="F:angiotensin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002033">
        <property type="term" value="P:angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0086097">
        <property type="term" value="P:phospholipase C-activating angiotensin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043123">
        <property type="term" value="P:positive regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050727">
        <property type="term" value="P:regulation of inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd15110">
        <property type="entry name" value="7tmA_MrgprH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000134">
        <property type="entry name" value="proto-oncogene Mas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026234">
        <property type="entry name" value="MRGPCRFAMILY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11334">
        <property type="entry name" value="MAS-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11334:SF29">
        <property type="entry name" value="MAS-RELATED G-PROTEIN COUPLED RECEPTOR MEMBER X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02108">
        <property type="entry name" value="MRGPCRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="101"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="190"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="49"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005005577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="329" mass="38007" checksum="80C1CC02587A935E" modified="2022-01-19" version="1">MDESNITFHPSEGTENISMHRNISTQERVWEILTPLWVIMIISFLGFCENGIVLWCLCFQIKRNPFTAYITHLSIADISLLFCVFILSIEYIAGFGFAYGFYYYITTTLSIVFLLGYNTGLYLLTAISIERCLSIVYPIWYRCHRSRHQSAIVCAILWTLSFLMTVAEYLTCKDDSTREQFDEANHCQAMLIFIWILTFLIFIPLMILSSLILVIRIHRNSLRPHSSKLYIIIVATVVVFLIFAMPMRLLYLLNYHHWSSLLSQQNHVTIVLSTVNSSINPLVYFFVGSSKKKRFKESLKVVLSRALADGLRPRSQEVGMSLDIAETIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y817</accession>
    <name>A0A8C2Y817_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y817"/>
    <dbReference type="Ensembl" id="ENSCJPT00005010684.1">
        <property type="protein sequence ID" value="ENSCJPP00005006863.1"/>
        <property type="gene ID" value="ENSCJPG00005006336.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034548850" evidence="2">
        <location>
            <begin position="20"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="173" mass="19825" checksum="E15DFCF20B877518" modified="2022-01-19" version="1">WSWLIFVLTLLQRQTPGSSHHKRLLNPRRNLEGNTERETGKQDVSEQSVSLETPKVQGSAYQNERQTPGSALLKWLLYLRRNWEEYKERETWKRNKRLPISEEAGSQDSTSHNISHGELTDLSNDMLGCKLMKNSDTEECEESELCPALATPWPSTGEKSDHQSPVARSPVDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y8Z0</accession>
    <name>A0A8C2Y8Z0_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SPHK1 interactor, AKAP domain containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">SPHKAP</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AKAP110 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015726888.1">
        <property type="nucleotide sequence ID" value="XM_015871402.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005013746.1">
        <property type="protein sequence ID" value="ENSCJPP00005009180.1"/>
        <property type="gene ID" value="ENSCJPG00005008110.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107318053"/>
    <dbReference type="CTD" id="80309"/>
    <dbReference type="GeneTree" id="ENSGT00940000153313"/>
    <dbReference type="OrthoDB" id="6154436at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051018">
        <property type="term" value="F:protein kinase A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018292">
        <property type="entry name" value="AKAP_110_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008382">
        <property type="entry name" value="SPHK1-interactor_AKAP_110"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10226">
        <property type="entry name" value="A KINASE ANCHOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10226:SF7">
        <property type="entry name" value="A-KINASE ANCHOR PROTEIN SPHKAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05716">
        <property type="entry name" value="AKAP_110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="A-kinase anchor 110kDa C-terminal" evidence="4">
        <location>
            <begin position="1602"/>
            <end position="1681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="356"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="516"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1372"/>
            <end position="1395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1433"/>
            <end position="1531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="365"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="518"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="541"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1434"/>
            <end position="1445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1451"/>
            <end position="1464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1472"/>
            <end position="1486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1506"/>
            <end position="1516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005009180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1695" mass="187735" checksum="BE0F67BCEB8D0695" modified="2022-01-19" version="1">MFRPAARRHTALRSNFESPLMQEVAEHQGNSTDSSGSSLGSTVTACKKILCSNSLLESTDYWLQNQRTPCQIGFLEDKSESNCASVCFVNLDANRDDCSNEQVKQKLISVSPNLPKLISSMNVQPPKENEIVLLSGLTSGNLQADYEVPQCPWQADVCLVQCARGDRKNSASCIIFEINKFLIGLELVQERQLQIEAHVSKPEDDTNCSVSSIEEDFLTASEHLEEENETDEYKTVAHDKISVSEASPDVRKNKGKGFESLHYRKARLPLILEGNCVNEDNTDSKVSEAVHVVAEDRISRPEDKPEQEILGQKELVGRASSPLSSEDLTNNVENSCSVNVLDVSLTKMAKEELGPLYDSTAKPSSKAEAEDCEGIRKSDPPLQNEQAATGQYATNLAESVLQDAFIRLSQSQPTFSEEAAVSISVGSSCKSKDASASRSWNELPKIVIVQSPDSSENVPDWPGSAFPNLCHWTETESSEVSDYFEEDHSNGHSQSALEMALACAATVIGTISSPQAAEKFRRDQEATDSKSEKVDNEDLHTNSSQLLEDGTSTEYSFPSALCGMTQVASAVAVCGLGETKEEKYPATSSGLLSAAQTSAAITLHCSIAVGSSMEKLNDSIAEALLKEASIILTKPNTYKNVGHFMESINGRIIETAARPRIPHSNEVIRDELAQNLSNIILRHSIEEVRKKRELQSHSENGSSTQDIFMEAANELLFNVIYFTCKKMNDIRQVEECSPLFSEGLKGKKVTRVEGWPTQATTCETSHRTLDHPAINPFGTSYSASKDTENGISTKKINMRDVNSNESATVNSELTSRAIGHNAFVAKTSPKKRYLKRTTRDCYKSPNQSNIQKKRDYRSFSDRESTFANNECRHGVQDQLPSSVVMNTENQAKCKCDAELSDEVQVSLSLLGNHVLLPSQPVLQVKNSRDKYCITDFAEELAETVVSMATEIAAICLENSNGKQPWFCAWKKGNEYLVTQSISCRTMKRKKETHANGSVVRKHRAPRLSEIKRKTDEHPELKERLMNRVVDESINLEDTPDSVNIFANEVAAKIMNLTELSMVDSIWQGPNHPRNRLHCERWSRAKASSCESIPEEDIDSKASVNTLGLMNALGQPVSQTSSVSKQSSCESITDEFSRFMVNQMENEGRGFDLLLDYYAGKNASSILTSALQQVAKKNGHLNVRPSCPSKQSSTESITEEFYRYMLKEIEKENKDNASSPRSSKDWCGNLLPPSLRSPFCFRQSSVPDGRSSGSRLTVNIPVKANSLDGFAQHHQDSLSVQPVSTVASSGLCKSDSCLYQRCKTDQITDMLIHETWASSIESLMRKNKIITDEAEVAEIDHFHSDSPTHVQQYANRLAADIVENGKNVIVVQQDASDSASQEHVPETKHPQGAAQIQVEPRRSGINLVEQKEHMKNSECLPAGQHREVPLIQIETDQRDESDKDSESLTLHELSEKEHQGKEKPPEAYAGKHTVSSTLLNSKSTQSKPDAEITGETKAAEEFPTHLSSSEESTGSWSQLANDEDNPDDTSSYLQLSERSLSNGNSSTTSSLGIMDLEIYQENVPPSPMINDLVEEKVFLKEQTDNTEESTSGLSVGTANYQKELLVINFDLEPECPNAELRATLQWIAASELGIPTIYFKKSQENRIEKFLDVVQLVQRKAWKVGDIFHAVVQYCKLSEESKEKTPSLFDWLLELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YC12</accession>
    <name>A0A8C2YC12_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Vestigial like family member 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">VGLL4</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May act as a specific coactivator for the mammalian TEFs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the vestigial family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015730272.1">
        <property type="nucleotide sequence ID" value="XM_015874786.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YC12"/>
    <dbReference type="SMR" id="A0A8C2YC12"/>
    <dbReference type="Ensembl" id="ENSCJPT00005022025.1">
        <property type="protein sequence ID" value="ENSCJPP00005015547.1"/>
        <property type="gene ID" value="ENSCJPG00005012862.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107319703"/>
    <dbReference type="CTD" id="9686"/>
    <dbReference type="GeneTree" id="ENSGT00390000003282"/>
    <dbReference type="OrthoDB" id="10040691at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001223">
        <property type="term" value="F:transcription coactivator binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060044">
        <property type="term" value="P:negative regulation of cardiac muscle cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035331">
        <property type="term" value="P:negative regulation of hippo signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045732">
        <property type="term" value="P:positive regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006627">
        <property type="entry name" value="TDU_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028184">
        <property type="entry name" value="VGLL4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17604">
        <property type="entry name" value="TRANSCRIPTION COFACTOR VESTIGIAL-LIKE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17604:SF1">
        <property type="entry name" value="TRANSCRIPTION COFACTOR VESTIGIAL-LIKE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15245">
        <property type="entry name" value="VGLL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00711">
        <property type="entry name" value="TDU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="260"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="98"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="282"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="294" mass="32297" checksum="94CC170A7FC1496A" modified="2022-01-19" version="1">MLFMKMDLLNYQYLDKMNNNIGILCYEGEAALRGEPRMQSLPVSSALTNHRTGPPPISPNKRKLSMDQGDDEIDCENEHVSKMSRMFNPHLNKTANGDYRKEHRERSRSPIERAAAPTMSLHANHMYASIPSLTMDQPLALTKNSMDATRTVGITPTLTSVERQQNRPSVITCASANNRNCNLSHCPIAHSGCGSAVPAYRRPSSTTTACDPVVEEHFRRSLGKNYKEPEPVANSVSITGSVDDHFAKALGDTWLQIKAAKDGVSSSPESASRRGQSSPSSHMVNHNHSPSVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YC22</accession>
    <name>A0A8C2YC22_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="3">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">UBE2D1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="3"/>
    <dbReference type="RefSeq" id="XP_015721676.1">
        <property type="nucleotide sequence ID" value="XM_015866190.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YC22"/>
    <dbReference type="Ensembl" id="ENSCJPT00005022099.1">
        <property type="protein sequence ID" value="ENSCJPP00005015607.1"/>
        <property type="gene ID" value="ENSCJPG00005012916.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107315637"/>
    <dbReference type="KEGG" id="cjo:107315637"/>
    <dbReference type="CTD" id="7321"/>
    <dbReference type="GeneTree" id="ENSGT00940000155109"/>
    <dbReference type="OrthoDB" id="7851174at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031669">
        <property type="term" value="P:cellular response to nutrient levels"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902916">
        <property type="term" value="P:positive regulation of protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070936">
        <property type="term" value="P:protein K48-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd23792">
        <property type="entry name" value="UBCc_UBE2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000101">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="10">
        <location>
            <begin position="4"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="8">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="150" mass="16897" checksum="F85F08EA93451E88" modified="2022-01-19" version="1">MEGSERTTRCLELSDLQRDPPAHCSAGPVGDDLFHWQATIMGPPDSAYQGGVFFLTVHFPTDYPFKPPKIAFTTKIYHPNINSNGSICLDILRSQWSPALTVSKVLLSICSLLCDPNPDDPLVPDIAQIYKSDKEKYNRHAREWTQKYAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YCA4</accession>
    <name>A0A8C2YCA4_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Villin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">VIL1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell projection</location>
            <location evidence="4">Filopodium tip</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cell projection</location>
            <location evidence="5">Lamellipodium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Microvillus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Ruffle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the villin/gelsolin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2YCA4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005022412.1">
        <property type="protein sequence ID" value="ENSCJPP00005015860.1"/>
        <property type="gene ID" value="ENSCJPG00005013096.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160544"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032432">
        <property type="term" value="C:actin filament bundle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005903">
        <property type="term" value="C:brush border"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032433">
        <property type="term" value="C:filopodium tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005902">
        <property type="term" value="C:microvillus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001726">
        <property type="term" value="C:ruffle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043027">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035727">
        <property type="term" value="F:lysophosphatidic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051014">
        <property type="term" value="P:actin filament severing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071364">
        <property type="term" value="P:cellular response to epidermal growth factor stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035729">
        <property type="term" value="P:cellular response to hepatocyte growth factor stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060327">
        <property type="term" value="P:cytoplasmic actin-based contraction involved in cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007173">
        <property type="term" value="P:epidermal growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030855">
        <property type="term" value="P:epithelial cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001951">
        <property type="term" value="P:intestinal D-glucose absorption"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032233">
        <property type="term" value="P:positive regulation of actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030836">
        <property type="term" value="P:positive regulation of actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010634">
        <property type="term" value="P:positive regulation of epithelial cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000394">
        <property type="term" value="P:positive regulation of lamellipodium morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040018">
        <property type="term" value="P:positive regulation of multicellular organism growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903078">
        <property type="term" value="P:positive regulation of protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051125">
        <property type="term" value="P:regulation of actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032532">
        <property type="term" value="P:regulation of microvillus length"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061041">
        <property type="term" value="P:regulation of wound healing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009617">
        <property type="term" value="P:response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902896">
        <property type="term" value="P:terminal web assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd11290">
        <property type="entry name" value="gelsolin_S1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11289">
        <property type="entry name" value="gelsolin_S2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11292">
        <property type="entry name" value="gelsolin_S3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11293">
        <property type="entry name" value="gelsolin_S4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11288">
        <property type="entry name" value="gelsolin_S5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11291">
        <property type="entry name" value="gelsolin_S6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000001">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000002">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000004">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000005">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000027">
        <property type="entry name" value="Villin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.950.10:FF:000005">
        <property type="entry name" value="Villin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.950.10">
        <property type="entry name" value="Villin headpiece domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007122">
        <property type="entry name" value="Villin/Gelsolin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003128">
        <property type="entry name" value="Villin_headpiece"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036886">
        <property type="entry name" value="Villin_headpiece_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977">
        <property type="entry name" value="VILLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977:SF35">
        <property type="entry name" value="VILLIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02209">
        <property type="entry name" value="VHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00597">
        <property type="entry name" value="GELSOLIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00262">
        <property type="entry name" value="GEL"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00153">
        <property type="entry name" value="VHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47050">
        <property type="entry name" value="VHP, Villin headpiece domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51089">
        <property type="entry name" value="HP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0117">Actin capping</keyword>
    <keyword evidence="12" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="14" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="HP" evidence="15">
        <location>
            <begin position="803"/>
            <end position="869"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00008418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00017436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="869" mass="97294" checksum="3F47F13F176C8768" modified="2022-01-19" version="1">MVNMGWDSWGQRSLLCWHPSTSPRYAHLVLSSAGKVPLPAANTMVELSKKVTGKLDKTTPGIQIWRIENMEMVPVPTKSYGNFYEGDCYVLLSTRKTGSGYSYNIHYWLGKNSSQDEQGAAAIYTTQMDEYLGSVAVQHREVQGHESETFRAYFKQGLIYKQGGVASGMKHVETNTYNVQRLLQVKGKKNVVAAEVEMSWKSFNLGDVFLLDLGQLIIQWNGPESNRAERLRAMTLAKDIRDRERAGRAKVGVVEGEDEGASPELMQALTHVLGEKKNIKAATPDDQVHEALNSALKLYHISDASGNLVIQEIAIRPLTQDMLQHEDCYILDQAGLKIFVWKGKNANREEKQQAMSRALGFIKAKNYPASTSVETENDGSESAVFRQLFQKWTVPNQTSGLGKTHTVGKVAKVEQVKFDATTMHVRPEVAAQQKMVDDGSGEAEVWRVENQELVPVEKRWLGHFYGGDCYLVLYTYYVGPKVNRIIYIWQGRHASADELAASAYQAVILDQKYNNEPVQVRVTMGKEPAHLMAIFKGKMVVYENGSSRAGNKEPAPSTRLFHVHGTNEYNTKAFEVPVRAASLNSNDVFVLKTPSSCYLWYGKGCSGDEREMGKMVADIISKSEKPVVAEGQEPPEFWVALGGKTSYANSKRLQEENPSVPPRLFECSNKTGRFLATEIVDFTQDDLEESDVYLLDTWDQIFFWIGKDANETEKEAAAVTAQEYLRSHPGSRDLDTPIIVVKQGYEPPTFTGWFMAWDPLCWSDKKSYDELKAELGDNASIGHLVSGLTSKNEVFTATTTLVPTKLETFPLDVLVNTAAEDLPRGVDPSRKENHLSDEDFKAVFGMTRSAFANMPLWKQQNLKKEKGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YD02</accession>
    <name>A0A8C2YD02_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="22">LARGE xylosyl- and glucuronyltransferase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">LARGE2</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Bifunctional glycosyltransferase with both alpha-1,3-xylosyltransferase and beta-1,3-glucuronyltransferase activities involved in the maturation of alpha-dystroglycan (DAG1) by glycosylation leading to DAG1 binding to laminin G-like domain-containing extracellular proteins with high affinity and in a phosphorylated-O-mannosyl trisaccharide dependent manner. Elongates the glucuronyl-beta-1,4-xylose-beta disaccharide primer structure by adding repeating units [-3-Xylose-alpha-1,3-GlcA-beta-1-] to produce a heteropolysaccharide. Supports the maturation of DAG1 more effectively than LARGE1. In addition, can modify both heparan sulfate (HS)- and chondroitin/dermatan sulfate (CS/DS)-proteoglycans (PGs), namely GPC4, with a glycosaminoglycan (GAG)-like polysaccharide composed of xylose and glucuronic acid to confer laminin binding.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>3-O-[beta-D-GlcA-(1-&gt;3)-beta-D-Xyl-(1-&gt;4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1-&gt;3)-beta-D-GlcNAc-(1-&gt;4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + UDP-alpha-D-xylose = 3-O-[alpha-D-Xyl-(1-&gt;3)-beta-D-GlcA-(1-&gt;4)-beta-D-Xyl-(1-&gt;4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1-&gt;3)-beta-D-GlcNAc-(1-&gt;4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:57336"/>
            <dbReference type="Rhea" id="RHEA-COMP:17482"/>
            <dbReference type="Rhea" id="RHEA-COMP:17483"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57632"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:177336"/>
            <dbReference type="ChEBI" id="CHEBI:177352"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:57337"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>3-O-{(1-&gt;[3)-alpha-D-Xyl-(1-&gt;3)-beta-D-GlcA-(1-&gt;](n)-4)-beta-D-Xyl-(1-&gt;4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1-&gt;3)-beta-D-GlcNAc-(1-&gt;4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + UDP-alpha-D-glucuronate = 3-O-{beta-D-GlcA-(1-&gt;[3)-alpha-D-Xyl-(1-&gt;3)-beta-D-GlcA-(1-&gt;](n)-4)-beta-D-Xyl-(1-&gt;4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1-&gt;3)-beta-D-GlcNAc-(1-&gt;4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67924"/>
            <dbReference type="Rhea" id="RHEA-COMP:17484"/>
            <dbReference type="Rhea" id="RHEA-COMP:17486"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:177354"/>
            <dbReference type="ChEBI" id="CHEBI:177355"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:67925"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>3-O-{beta-D-GlcA-(1-&gt;[3)-alpha-D-Xyl-(1-&gt;3)-beta-D-GlcA-(1-&gt;](n)-4)-beta-D-Xyl-(1-&gt;4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1-&gt;3)-beta-D-GlcNAc-(1-&gt;4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + UDP-alpha-D-xylose = 3-O-{(1-&gt;[3)-alpha-D-Xyl-(1-&gt;3)-beta-D-GlcA-(1-&gt;](n+1)-4)-beta-D-Xyl-(1-&gt;4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1-&gt;3)-beta-D-GlcNAc-(1-&gt;4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:68368"/>
            <dbReference type="Rhea" id="RHEA-COMP:17485"/>
            <dbReference type="Rhea" id="RHEA-COMP:17486"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57632"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:177354"/>
            <dbReference type="ChEBI" id="CHEBI:177355"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:68369"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">In the C-terminal section; belongs to the glycosyltransferase 49 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">In the N-terminal section; belongs to the glycosyltransferase 8 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_032300782.1">
        <property type="nucleotide sequence ID" value="XM_032444891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YD02"/>
    <dbReference type="Ensembl" id="ENSCJPT00005024465.1">
        <property type="protein sequence ID" value="ENSCJPP00005017577.1"/>
        <property type="gene ID" value="ENSCJPG00005014313.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107314765"/>
    <dbReference type="KEGG" id="cjo:107314765"/>
    <dbReference type="CTD" id="120071"/>
    <dbReference type="GeneTree" id="ENSGT00940000158758"/>
    <dbReference type="OrthoDB" id="411524at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042285">
        <property type="term" value="F:xylosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd06431">
        <property type="entry name" value="GT8_LARGE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000229">
        <property type="entry name" value="Glycosyltransferase-like protein LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000016">
        <property type="entry name" value="LARGE xylosyl- and glucuronyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051292">
        <property type="entry name" value="Xyl/GlcA_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12270">
        <property type="entry name" value="GLYCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12270:SF23">
        <property type="entry name" value="XYLOSYL- AND GLUCURONYLTRANSFERASE LARGE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13896">
        <property type="entry name" value="Glyco_transf_49"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="21" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="coiled-coil region" evidence="21">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00038461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00038468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00045795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005017577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="739" mass="85593" checksum="E70938475180659C" modified="2022-01-19" version="1">MLCSWRVKLKLLLATITLAVLLSWLYLFVGSLEYGRFLLLPPCLGEQPSRDVEREALASQVRRVEEENQQLRMQLGQVQVEGSDGIPQWAASAEDGSPPGGERNNRTACLKQRMVHKCELLHVAIVCAGHNASRDVVTLVKSILFHRKNPLHFHFITDSVAHQILQTLFQSWMVPSIHVSFYNADDLKPEVSWIPNKHYSGIYGLMKLTLTKALPSNLSKVIVLDTDITFATDIAELWAVFGKFSEKQVIGLVENQSDWYLGNLWKNHKPWPALGRGFNTGVILLLLDRLRRLGWEQMWRLTAERELMSMLSTSLADQDIFNAVIKQNPALVYRLPCFWNVQLSDHTRSELCYTEVSDLKVIHWNSPKKLRVKNKHVEFFRNLYLTFLEYDGNLLRRELFGCASLPSPPSDQLQQALEELDEDDPCYDFRRQHLTQHRVHLFFLQYEFLALPNPTDVTLVAQLSMDRLQMLEAICKHWAGPISLALYMSDAEAQQFLRYAQASEVLSARRNVAYHIVYKEGQFYPINLLRNVALANTQTPYVFLTDIDFLPMYGLYDYLRNSIQQLELPHRKAALIVPAFETLHYRLTFPKSKAELLSMLDMGSLYTFRYHVWPKGHAPTDYAKWRTATVPYRVAWQPDFEPYVVVRRDCPKYDQRFVGFGWNKVSHIMELDAQEYELLVLPNAFMIHMPHAPSFDISKFRLSAGYRGCLQTLREEFHQDLSRRYGAAALKYLTAERNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YDZ1</accession>
    <name>A0A8C2YDZ1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">B30.2/SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YDZ1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005026917.1">
        <property type="protein sequence ID" value="ENSCJPP00005019439.1"/>
        <property type="gene ID" value="ENSCJPG00005015746.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153527"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="CDD" id="cd12888">
        <property type="entry name" value="SPRY_PRY_TRIM7_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000004">
        <property type="entry name" value="Butyrophilin subfamily 1 member A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003879">
        <property type="entry name" value="Butyrophylin_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006574">
        <property type="entry name" value="PRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050143">
        <property type="entry name" value="TRIM/RBCC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24103">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13765">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01407">
        <property type="entry name" value="BUTYPHLNCDUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00589">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="1">
        <location>
            <begin position="16"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005019439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="203" mass="23162" checksum="F5ACCF85F48C2DCA" modified="2022-01-19" version="1">MCPSPPVFVVSSRRPVGIWGRIQLNRFNSFFSIVNVTLDPDTAHPRLILSEDQKSVRWEYSFQESPDGPERFDVDPCVLGCESFTSGRHCWVVDLSEGQYCAVGVSRESLQRKGAVSFNPDEGIWAVQQWGFKNRALTSPPTPLNLPRVPKKIRISLDYEWGEVAFFDAENQIPIFTFPLARFGGERLRPWFWVELGSLSLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YEX9</accession>
    <name>A0A8C2YEX9_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Organic solute transporter subunit alpha-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC107325174</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015741255.1">
        <property type="nucleotide sequence ID" value="XM_015885769.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YEX9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005029621.1">
        <property type="protein sequence ID" value="ENSCJPP00005021576.1"/>
        <property type="gene ID" value="ENSCJPG00005017268.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107325174"/>
    <dbReference type="KEGG" id="cjo:107325174"/>
    <dbReference type="GeneTree" id="ENSGT00940000163831"/>
    <dbReference type="OrthoDB" id="5832279at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005021576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="336" mass="37923" checksum="ED7716D0D67535AD" modified="2022-01-19" version="1">MEGEVNGTFLPSCGESEPPYAQELLESLDLAGRFLFAILTLMTLIANLVFIEEVIYIYRKIPSSKRSILIWINAAAPVIATTSCIGMWIPRSTMFTDFTASVFFAIVIHKFLMMMIKECGGQKLFLKRFENGHFKISTGPCCCCCLCLPGVRITRRSLFWLKLGTFQFAVFRPVFMFLSTVLWTNGNYSLSNLSPKGAAIWISCFIAILTIIALWPVAIMFQQVRVLLNCKKIIPKFALYQFILILNHLQTAIINILAMQRIIPCAPPLSSPARGAYISHQVLIMEMFLITLIARVVYRRRYDELDPPECITEEAGVKKQTPILNVTVSEDGLRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YF28</accession>
    <name>A0A8C2YF28_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Nescient helix-loop-helix 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">NHLH2</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015730518.1">
        <property type="nucleotide sequence ID" value="XM_015875032.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015730527.1">
        <property type="nucleotide sequence ID" value="XM_015875041.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032303263.1">
        <property type="nucleotide sequence ID" value="XM_032447372.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032303269.1">
        <property type="nucleotide sequence ID" value="XM_032447378.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032303270.1">
        <property type="nucleotide sequence ID" value="XM_032447379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YF28"/>
    <dbReference type="Ensembl" id="ENSCJPT00005029851.1">
        <property type="protein sequence ID" value="ENSCJPP00005021781.1"/>
        <property type="gene ID" value="ENSCJPG00005017385.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107319825"/>
    <dbReference type="KEGG" id="cjo:107319825"/>
    <dbReference type="CTD" id="4808"/>
    <dbReference type="GeneTree" id="ENSGT00940000162602"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061629">
        <property type="term" value="F:RNA polymerase II-specific DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001223">
        <property type="term" value="F:transcription coactivator binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021535">
        <property type="term" value="P:cell migration in hindbrain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021888">
        <property type="term" value="P:hypothalamus gonadotrophin-releasing hormone neuron development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008584">
        <property type="term" value="P:male gonad development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060179">
        <property type="term" value="P:male mating behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042698">
        <property type="term" value="P:ovulation cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007422">
        <property type="term" value="P:peripheral nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd19701">
        <property type="entry name" value="bHLH_TS_HEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000027">
        <property type="entry name" value="Nescient helix-loop-helix 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040238">
        <property type="entry name" value="TAL-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13864:SF19">
        <property type="entry name" value="HELIX-LOOP-HELIX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13864">
        <property type="entry name" value="T-CELL ACUTE LYMPHOCYTIC LEUKEMIA/STEM CELL LEUKEMIA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="2" id="KW-0221">Differentiation</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="8">
        <location>
            <begin position="80"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="71"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005021781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="138" mass="14829" checksum="0FF7AC46DB69A270" modified="2022-01-19" version="1">MMLSPDQAADSDHPSSAPSDPESLGGADGRALSCCVSDPEPAEGGGGGGGGESRGGGRPGLHPPPLSREEKRRRRRATAKYRSAHATRERIRVEAFNMAFAELRKLLPTLPPDKKLSKIEILRLAICYISYLNHVLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YFU1</accession>
    <name>A0A8C2YFU1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pleckstrin homology-like domain family A member 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Imprinted in placenta and liver protein</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Plays a role in regulating placenta growth. May act via its PH domain that competes with other PH domain-containing proteins, thereby preventing their binding to membrane lipids.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PHLDA2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2YFU1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005032116.1">
        <property type="protein sequence ID" value="ENSCJPP00005023438.1"/>
        <property type="gene ID" value="ENSCJPG00005018595.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00440000039564"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901981">
        <property type="term" value="F:phosphatidylinositol phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000270">
        <property type="entry name" value="Pleckstrin homology-like domain family A member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042832">
        <property type="entry name" value="PHLA1/2/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15478:SF8">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY-LIKE DOMAIN FAMILY A MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15478">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY-LIKE DOMAIN, PQ-RICH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="10">
        <location>
            <begin position="7"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="119"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005023438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="160" mass="18385" checksum="FFD94EB91C0EE8D6" modified="2022-01-19" version="1">MKMQAEVIREGELEKRSDSLFQLWKKKLVVLTKDSLSLFPDGHKQAKGKELGFGSILKVDCVERTGKYIYFTIVTKDRKEIDFRCPDQSCWNASITMALIDFQNKRAIQDFKSRQEMEQAAGTQERRLARAKKASSPLLSSPHPQPGMPVAEYYCCRLYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YGT8</accession>
    <name>A0A8C2YGT8_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Inositol 1,4,5-trisphosphate receptor-interacting protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">ITPRIP</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Enhances Ca(2+)-mediated inhibition of inositol 1,4,5-triphosphate receptor (ITPR) Ca(2+) release.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus outer membrane</location>
            <topology evidence="3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ITPRIP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015722709.1">
        <property type="nucleotide sequence ID" value="XM_015867223.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015722710.1">
        <property type="nucleotide sequence ID" value="XM_015867224.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015722711.1">
        <property type="nucleotide sequence ID" value="XM_015867225.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015722712.1">
        <property type="nucleotide sequence ID" value="XM_015867226.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YGT8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005034677.1">
        <property type="protein sequence ID" value="ENSCJPP00005025514.1"/>
        <property type="gene ID" value="ENSCJPG00005020012.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107316086"/>
    <dbReference type="KEGG" id="cjo:107316086"/>
    <dbReference type="CTD" id="85450"/>
    <dbReference type="GeneTree" id="ENSGT01050000244827"/>
    <dbReference type="OrthoDB" id="9923553at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005640">
        <property type="term" value="C:nuclear outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004860">
        <property type="term" value="F:protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008625">
        <property type="term" value="P:extrinsic apoptotic signaling pathway via death domain receptors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902042">
        <property type="term" value="P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1410.40:FF:000008">
        <property type="entry name" value="Inositol 1,4,5-trisphosphate receptor-interacting protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026250">
        <property type="entry name" value="ITPRIP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046906">
        <property type="entry name" value="Mab-21_HhH/H2TH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024810">
        <property type="entry name" value="MAB21L/cGLR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10656">
        <property type="entry name" value="CELL FATE DETERMINING PROTEIN MAB21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10656:SF8">
        <property type="entry name" value="INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20266">
        <property type="entry name" value="Mab-21_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02107">
        <property type="entry name" value="INOS145TPRIP"/>
    </dbReference>
    <dbReference type="SMART" id="SM01265">
        <property type="entry name" value="Mab-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034614006" description="Inositol 1,4,5-trisphosphate receptor-interacting protein" evidence="15">
        <location>
            <begin position="16"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="Mab-21-like HhH/H2TH-like" evidence="16">
        <location>
            <begin position="403"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="31"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF20266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005025514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="549" mass="63084" checksum="F82AFB9231724E67" modified="2022-01-19" version="1">MPMGIFRVCLVVITAIVNHPLLFPKENGTVLENTEEIIQKMKEREEILRLEKLRLEQEIESQEAAQKVLEKAAKVVEDVKEDKVQWDMWTALSMVIFLLIELWRQDFQEGNWQDTGADEDDIAVLGKAFKGVAFPDKAILASFYEKRILGTTGDMARMREMVEGFADDLLEALRSVCNRDADMEVEDCMGVGSMYENWRVRKPFVCDLIVPFAPPEPYCFRSQIWCSGDSFPPDEQGYGTIKVCRADEDETGCICDKTKLGEDMLCLLHSQGNTTRLSSEMEDLLCFKNTQYLDADQVMKWFQIAVTKAWNKISHKYEFDLSFSLLDSPGALKIKFRSGKSIAFNLTPVVQYENSDVYFISHFPRNCLAADVPSSTHWFLTFAVYERRFIQMVSKMLPANACHVSCLQILTFLHGKQCSLTGPSGLTNYHLKTVLLHLLQTRPSQDWAPEKLEARLQDMLKFLEKCLHEKKLYHFFIGNGKVPAELGFPIIFQRAEPLNLFRPFVLHRAVYKKTVDTFHEMLRNTSALINEYMVHIPHVHTNGIQKESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YHK4</accession>
    <name>A0A8C2YHK4_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Oxysterol-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">OSBPL11</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Plays a role in regulating ADIPOQ and FABP4 levels in differentiating adipocytes and is also involved in regulation of adipocyte triglyceride storage. Weakly binds 25-hydroxycholesterol. Interacts with OSBPL9 to function as lipid transfer proteins. Together they form a heterodimer that localizes at the ER-trans-Golgi membrane contact sites, and exchanges phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine, PS) for phosphatidylinositol-4-phosphate (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate), PI(4)P) between the two organelles, a step that is critical for sphingomyelin synthesis in the Golgi complex.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(out) + a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(in) + a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)</text>
            <dbReference type="Rhea" id="RHEA:81667"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Heterodimer with OSBPL9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Late endosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the OSBP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2YHK4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005036691.1">
        <property type="protein sequence ID" value="ENSCJPP00005027088.1"/>
        <property type="gene ID" value="ENSCJPG00005021041.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158398"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045444">
        <property type="term" value="P:fat cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070328">
        <property type="term" value="P:triglyceride homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd13291">
        <property type="entry name" value="PH_ORP10_ORP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2720:FF:000001">
        <property type="entry name" value="Oxysterol-binding OBPalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000154">
        <property type="entry name" value="Oxysterol-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000002">
        <property type="entry name" value="Oxysterol-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3490:FF:000001">
        <property type="entry name" value="Oxysterol-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF46">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 15" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 15" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PH" evidence="17">
        <location>
            <begin position="39"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00058048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00065555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005027088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="745" mass="83820" checksum="99D5CA82C1AD47DB" modified="2022-01-19" version="1">MQCAEPAAVKGPEGEGKAEPAAGKSGGRSAKGWQYSDHMENICGYLMKYTNLVTGWQYRFFVLNNDAGLLEYFVNEQSRHLKPRGTLQLAGAVISPSDEDSHTFTVNAASGEQYKLRATDAKERQHWVSRLQICTQHHTEAIGKNNPPLKSRSFSLASQGSINSPGLQRRPSQNAVSFFNVGHHRLPAGKKGPILQPDHLVDVREMMSQAEGQQRDLIRSIECLPVSGHLTSLDQDLLMLKATSMATMNCLNDCFHILQLQHASQQKGSLPAGTTISWLEPKISLSNHFKNGAAQNFPAEINKPASVREEQSVAEPCQLTREPEEINSDEELEDLCDNKEDDLGGVEEQRSVILHLLSQLKLGMDLTRVVLPTFILEKRSLLEMYADFMSHPDLFIAITNGTTPEERMICFVEYYLTAFHEGRKGAIAKKPYNPIIGETFHCSWRMPKSEVATDGGSNISAHSASEQITLSKDVEGQAESDYYTVKFVAEQVSHHPPVSGFYAECVERKMCVNAHVWTKSKFLGMSIGVTMVGEGLLSLLEHEEEYTFSLPCAYARSILTVPWVELGGKVNINCAKTGYSASINFHTKPFYGGKLHRVTGEVKQNATNTVVCRVQGEWNSVLEFTYSNGETKYVDLTKLSVTRKRVRPIEKQGPFESRRLWQHVTESLRDGDIDKATEHKRALEERQRNEERLRAETETPWCTKYFIKEVSPRVVSWQRQSYSRNRCMCGCVLASYHLVTWDAYW</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1996-02-01" modified="2026-01-28" version="130" xmlns="https://uniprot.org/uniprot">
    <accession>P47238</accession>
    <name>PAX6_COTJA</name>
    <protein>
        <recommendedName>
            <fullName>Paired box protein Pax-6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Pax-QNR</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">PAX6</name>
    </gene>
    <organism>
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1992" name="Oncogene" volume="7" first="1721" last="1728">
            <title>Characterization of a paired box- and homeobox-containing quail gene (Pax-QNR) expressed in the neuroretina.</title>
            <authorList>
                <person name="Martin P"/>
                <person name="Carriere C"/>
                <person name="Dozier C"/>
                <person name="Quatannens B"/>
                <person name="Mirabel MAA"/>
                <person name="Vandenbunder B"/>
                <person name="Stehelin D"/>
                <person name="Saule S"/>
            </authorList>
            <dbReference type="PubMed" id="1354346"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA]</scope>
        <source>
            <tissue>Neuroretina</tissue>
        </source>
    </reference>
    <comment type="function">
        <text>May be a transcription factor with important functions in eye and nasal development.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the paired homeobox family.</text>
    </comment>
    <dbReference type="EMBL" id="X70475">
        <property type="protein sequence ID" value="CAA49899.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015718965.1">
        <property type="nucleotide sequence ID" value="XM_015863479.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032301100.1">
        <property type="nucleotide sequence ID" value="XM_032445209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P47238"/>
    <dbReference type="BMRB" id="P47238"/>
    <dbReference type="SMR" id="P47238"/>
    <dbReference type="Ensembl" id="ENSCJPT00005026234.1">
        <property type="protein sequence ID" value="ENSCJPP00005018925.1"/>
        <property type="gene ID" value="ENSCJPG00005015377.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107314344"/>
    <dbReference type="KEGG" id="cjo:107314344"/>
    <dbReference type="CTD" id="5080"/>
    <dbReference type="GeneTree" id="ENSGT00940000155391"/>
    <dbReference type="OrthoDB" id="3225452at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043010">
        <property type="term" value="P:camera-type eye development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007417">
        <property type="term" value="P:central nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050877">
        <property type="term" value="P:nervous system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003322">
        <property type="term" value="P:pancreatic A cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00131">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000003">
        <property type="entry name" value="Paired box protein Pax-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000069">
        <property type="entry name" value="Paired box protein Pax-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000028">
        <property type="entry name" value="Paired box protein Pax-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043182">
        <property type="entry name" value="PAIRED_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001523">
        <property type="entry name" value="Paired_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043565">
        <property type="entry name" value="PAX_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636:SF48">
        <property type="entry name" value="PAIRED BOX PROTEIN PAX-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636">
        <property type="entry name" value="PAIRED BOX PROTEIN PAX-6-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00292">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00027">
        <property type="entry name" value="PAIREDBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00351">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00034">
        <property type="entry name" value="PAIRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51057">
        <property type="entry name" value="PAIRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0217">Developmental protein</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0371">Homeobox</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0563">Paired box</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000050189" description="Paired box protein Pax-6">
        <location>
            <begin position="1"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Paired" evidence="2">
        <location>
            <begin position="4"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="1">
        <location>
            <begin position="210"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="PAI subdomain" evidence="2">
        <location>
            <begin position="7"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="RED subdomain" evidence="2">
        <location>
            <begin position="82"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="164"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="270"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="281"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="416" mass="46028" checksum="0B14695A42B63845" modified="1996-02-01" version="1">MQNSHSGVNQLGGVFVNGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIRPRAIGGSKPRVATPEVVSKIAQYKRECPSIFAWEIRDRLLSEGVCTNDNIPSVSSINRVLRNLASEKQQMGADGMYDKLRMLNGQTGTWGTRPGWYPGTSVPGQPAQDGCPQQEGGGENTNSISSNGEDSDEAQMRLQLKRKLQRNRTSFTQEQIEALEKEFERTHYPDVFARERLAAKIDLPEARIQVWFSNRRAKWRREEKLRNQRRQASNTPSHIPISSSFSTSVYQPIPQPTTPGSMLGRTDTALTNTYSALPPMPSFTMANNLPMQPPVPSQTSSYSCMLPTSPSVNGRSYDTYTPPHMQTHMNSQPMGTSGTTSTGLISPGVSVPVQVPGSEPDMSQYWPRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SN95</accession>
    <name>A0A8C2SN95_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ankyrin repeat domain-containing protein 9-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC107310887</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015712444.1">
        <property type="nucleotide sequence ID" value="XM_015856958.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SN95"/>
    <dbReference type="Ensembl" id="ENSCJPT00005002197.1">
        <property type="protein sequence ID" value="ENSCJPP00005001300.1"/>
        <property type="gene ID" value="ENSCJPG00005001344.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107310887"/>
    <dbReference type="KEGG" id="cjo:107310887"/>
    <dbReference type="GeneTree" id="ENSGT00940000164440"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000206">
        <property type="entry name" value="Ankyrin repeat domain-containing protein 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="142"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005001300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="293" mass="33597" checksum="B698C30D09D9092B" modified="2022-01-19" version="1">MASNQASMQDDQSRHCKFLSYMFYQAVRDHKPVWMLEDMRTMEYFYWEENASLRTYSPSEALLYAVVHNHLPYAQYLLSHFPEEALKVPGEHFCYCPSSAPHLAMAVTYDRRDILGLIIKIAHKLPSLNSYINRTGCFHLEDGKTPLHLACELLRSETVLILLGNGASPRIEDSKGLTPLDVILEQMWDSKVNMATKKLCLDYLLLFMPNPQFKMQKVLQDHPEHWTALLGEEKFNSLVGNTPASLYLQAMQTILQTLPPSHFPKSIQELPIPQALKPLPSYGKKQSTKNVHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SNW2</accession>
    <name>A0A8C2SNW2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Receptor ligand binding region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SNW2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005002594.1">
        <property type="protein sequence ID" value="ENSCJPP00005001564.1"/>
        <property type="gene ID" value="ENSCJPG00005001578.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159109"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005001564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="178" mass="18666" checksum="7708ADC02C8969A0" modified="2022-01-19" version="1">MGQLWVLWGSYGVLWGAIGRSIPLLPAFLAFTLSCAGPFPEVKRPPLNVAIVLRGSPIPSDLLNPPFPPGVTPVPLRMDEGDPRSLLVRLCDLLSSLKLHGVVFDDKAGAEAVAHILDFVSAQAAVPIVGVSGGAATVMAPKVRGGYGGLWVSMGLYGVRGGYGDLWVSMGPYGSLWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SP83</accession>
    <name>A0A8C2SP83_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Translation initiation factor IF-2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">MTIF2</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SP83"/>
    <dbReference type="Ensembl" id="ENSCJPT00005001418.1">
        <property type="protein sequence ID" value="ENSCJPP00005000810.1"/>
        <property type="gene ID" value="ENSCJPG00005000879.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00900000141103"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01887">
        <property type="entry name" value="IF2_eIF5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03702">
        <property type="entry name" value="IF2_mtIF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03692">
        <property type="entry name" value="mtIF2_IVc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000007">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10050:FF:000001">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000019">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000072">
        <property type="entry name" value="translation initiation factor IF-2, mitochondrial isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="entry name" value="Translation initiation factor IF- 2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00100_B">
        <property type="entry name" value="IF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053905">
        <property type="entry name" value="EF-G-like_DII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044145">
        <property type="entry name" value="IF2_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000178">
        <property type="entry name" value="TF_IF2_bacterial-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381:SF20">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22042">
        <property type="entry name" value="EF-G_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="Initiation factor IF2/eIF5b, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01176">
        <property type="entry name" value="IF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tr-type G" evidence="12">
        <location>
            <begin position="185"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="456"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005000810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="733" mass="81957" checksum="D12C9E4AFADE90D9" modified="2022-01-19" version="1">MWAKCEEMNRRLILKLENLIRFHGACSQLHTLVCRRVCRAQWKPVPSSVHPTRSVHPYPQCWEKDKLIRAASSPCRCLATKEEKKKDRRKLPMTKGEVEIRQQMTIEELARAMGKDVDHVYEALLYTDIDVNSLEPDSILYEDSIKLIVKKSGMKYKSAKLREEKERENKDAVKRPPADPAFLTPRPPVVTIMGHVDHGKTTLLDSLRKTQVAAMEAGGITQHIGAFLVHLPSGEKITFLDTPGHAAFSAMRARGTYVTDIVILVVAAEDGVMQQTIESIEHAKNAGVPLVLAINKCDKPEADPERVKKELLAHGVVCEEFGGDVQAVNISALKGDNLMVLAEATVVLAEMLELKADYTGLVEGTIIESRKDKGKGPVTTAIIQRGTLRKGCVLVAGKTWAKVRLMFDENGKAVDAASPGIPVEIMGWKEVPSAGDEILEVESEQRAHEVVAWRTYVEQQEKMKKDREVIEAKQKEHRMEYEKKQQNLAHLTWRQRKAALYKEGKHLMLIKPKERAEIDKNVLSIIIKGDVDGSVEAILNVLDSYDADDECKLEVIHFGMGDISETDLSLAETFNGVVYGFSVKANETIKKMAAKKGIKIKLHNIIYKLIEDLKDELSSRLPPSVVENTVGEASVLDTFSVTVGKNKVPVAGCRVQKGQLDKKMKFKLIRKGNVIWKGSLSSLKHHKDDVQVIKTGMDCGLSLDKHIEFSIGDEIICYEEKEIQQTTSWNPGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SQZ3</accession>
    <name>A0A8C2SQZ3_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SQZ3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005002487.1">
        <property type="protein sequence ID" value="ENSCJPP00005001506.1"/>
        <property type="gene ID" value="ENSCJPG00005001521.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161745"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071456">
        <property type="term" value="P:cellular response to hypoxia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000076">
        <property type="entry name" value="hypoxia-inducible factor 3-alpha isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23043">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23043:SF18">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 3-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23171">
        <property type="entry name" value="bHLH_HIF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="5">
        <location>
            <begin position="13"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005001506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="82" mass="9156" checksum="EB1F011C5BD2680D" modified="2022-01-19" version="1">GEGGGGSSSTPELRKERSRDAARCRRSRETEVFYQLAHTLPFARGVSAHLDKASIMRLTISYLRVHRLLAAGETLYRIRGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SRE7</accession>
    <name>A0A8C2SRE7_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SRE7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005004967.1">
        <property type="protein sequence ID" value="ENSCJPP00005002672.1"/>
        <property type="gene ID" value="ENSCJPG00005002981.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005002672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="186" mass="19430" checksum="6C3197936EDB2FAF" modified="2022-01-19" version="1">SRCTAGGDGVRCVCMVNSIPDSSLVFELPTRNQTVSDGHRDFTAAPPGSDGSITGILTLRGPLEPRLLVLCAARNRHGTTARQLRFHHPGGLVWAKVGPVGAVVAFAIVIAVVCYLSQSRPPNFRRNPPTLLIPEVPLLTPAAAALSLPLYRPLAAGGKTSPPSSPLTILTAPFALPSPPPTPEPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SRL8</accession>
    <name>A0A8C2SRL8_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Potassium two pore domain channel subfamily K member 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">KCNK12</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_032299462.1">
        <property type="nucleotide sequence ID" value="XM_032443571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SRL8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005002449.1">
        <property type="protein sequence ID" value="ENSCJPP00005001484.1"/>
        <property type="gene ID" value="ENSCJPG00005001496.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107310864"/>
    <dbReference type="CTD" id="56660"/>
    <dbReference type="GeneTree" id="ENSGT00940000161424"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000070">
        <property type="entry name" value="Potassium channel, subfamily K, member 12 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005410">
        <property type="entry name" value="2pore_dom_K_chnl_THIK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF11">
        <property type="entry name" value="POTASSIUM CHANNEL SUBFAMILY K MEMBER 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01588">
        <property type="entry name" value="THIKCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14 16" id="KW-0407">Ion channel</keyword>
    <keyword evidence="12 16" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0630">Potassium</keyword>
    <keyword evidence="8" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="5" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 16" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="18">
        <location>
            <begin position="98"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="18">
        <location>
            <begin position="210"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005001484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="415" mass="46164" checksum="6D512DEE6F623520" modified="2022-01-19" version="1">MMPRRGAAGPRRRRRPAPLNEDNGRFLLLAALIAAYLSAGATVFSALESPSEAAAQLRWNRTLHNFSRIFNISLPELRAFLRSYEAAMAAGIRVDALRPRWDFPGAFYFVGTVVSTIGFGMTTPATVAGKVFLIVYGLFGCAGTILFFNLFLERIISLLAFIMKACHERQLRRSGLLPPNFRRGSAMSGVGSLIGWKPSVYHVMLILGIFAIMLSCCASAMYTLVEGWNYVDSLYYCFVTFSTIGFGDLVSSQNAVYQNQGLYRFGNFVFILMGVCCIYSLFNVISIVIKQLLNWVLKKFRCRCCPKCHKSSTRLGRRNAITPGARLRRHKISLEADGQYDSDTDGRRLSGEMISMRELTASNKVSLAILQKQLYETANGYPRNVCINTRQNGFSAGVGALAIMNNRLAETSDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SRW7</accession>
    <name>A0A8C2SRW7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Double-stranded RNA-binding protein Staufen homolog 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">STAU1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Binds double-stranded RNA (regardless of the sequence) and tubulin. May play a role in specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in stimulating their translation at the site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Rough endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015737119.1">
        <property type="nucleotide sequence ID" value="XM_015881633.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SRW7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005004074.1">
        <property type="protein sequence ID" value="ENSCJPP00005002250.1"/>
        <property type="gene ID" value="ENSCJPG00005002450.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107322981"/>
    <dbReference type="CTD" id="6780"/>
    <dbReference type="GeneTree" id="ENSGT00940000157304"/>
    <dbReference type="OrthoDB" id="10056847at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032839">
        <property type="term" value="C:dendrite cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005791">
        <property type="term" value="C:rough endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098964">
        <property type="term" value="P:anterograde dendritic transport of messenger ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007281">
        <property type="term" value="P:germ cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0008298">
        <property type="term" value="P:intracellular mRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046726">
        <property type="term" value="P:positive regulation by virus of viral protein levels in host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:positive regulation of viral genome replication"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:protein localization to synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19879">
        <property type="entry name" value="DSRM_STAU1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19881">
        <property type="entry name" value="DSRM_STAU1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19883">
        <property type="entry name" value="DSRM_STAU1_rpt3"/>
        <property type="match status" value="1"/>
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    <dbReference type="CDD" id="cd19885">
        <property type="entry name" value="DSRM_STAU1_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19887">
        <property type="entry name" value="DSRM_STAU1_rpt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000007">
        <property type="entry name" value="Double-stranded RNA-binding protein Staufen homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000014">
        <property type="entry name" value="double-stranded RNA-binding protein Staufen homolog 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000024">
        <property type="entry name" value="double-stranded RNA-binding protein Staufen homolog 1 isoform X1"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.30.160.20:FF:000013">
        <property type="entry name" value="double-stranded RNA-binding protein Staufen homolog 2 isoform X3"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="5"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="DRBM-containing_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044475">
        <property type="entry name" value="STAU1_DSRM_3"/>
    </dbReference>
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        <property type="entry name" value="Staufen_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46054:SF2">
        <property type="entry name" value="DOUBLE-STRANDED RNA-BINDING PROTEIN STAUFEN HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46054">
        <property type="entry name" value="MATERNAL EFFECT PROTEIN STAUFEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16482">
        <property type="entry name" value="Staufen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 10" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DRBM" evidence="12">
        <location>
            <begin position="76"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="12">
        <location>
            <begin position="162"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="12">
        <location>
            <begin position="274"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="12">
        <location>
            <begin position="376"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="15"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="137"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="445"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="683"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="255"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="456"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="693"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004427"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
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            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00069815"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005002250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="706" mass="77314" checksum="5868DF6F3CBDDBC9" modified="2022-01-19" version="1">MSQVQIQNPAAALAGSQMLNKNPSLSQPLSIPSTTSSLPSENAGRPIQNSALPSASVTSTNAAAAPSNMANPKEKTPMCLVNELARFNRIQPQYKLLSEQGPAHSKVFTVQLTLGDQHWEAEGTSIKKAQHAAAAKALEGTKFPKPTARPSRSEGKNPDSVTPTVELNALCMKLGKKPLYKPIDPYTGMRSTYNYTMRGGTYPPRYFYPFPVGPLLYQVELSIGGQQFHGKGRTRQAAKHDAAAKALKVLQNEPLPEKPEVNGKEPDDENLNKSEISQVFEIALKRNLPVNFEVTKESGPPHMKSFVTKVSVGEFMGEGEGKSKKISKKNAAIAVLEELKKLPPLPTVEKMKPRIKKKTKSIVKLQTSPEYGQGMNPISRLAQIQQAKKEKEPEYMLITERGLPRRREFVMQVKVGVHTAEGMGTNKKVAKRNAAENMLEILGFKIPQPQPPKPALKTEEKTPVKKTGDGRKVTFFEPGSEETSTSNKEDEFRMPYLSHQQLPAGILPMVPEVAQAVGASQGHHTKEFNRAAPNPAKATVTAMIARELLYGGTSPTAETILKNNNSSGHVPHGPLTRPSEQLDYLSNVQGIQVEYKDFPKNNKNEFVSLINCSSQPPLISHGIGKDVESCHDMAALNILKLLSELDQQNTEMPRTGNGPMSVEVKIPRAVTFLRRTRGCVKQEMESDPLLKPANSNTLGQTLDSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2STL5</accession>
    <name>A0A8C2STL5_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WD repeat domain 25</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">WDR25</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2STL5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005004556.1">
        <property type="protein sequence ID" value="ENSCJPP00005002472.1"/>
        <property type="gene ID" value="ENSCJPG00005002734.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063583"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053053">
        <property type="entry name" value="WD_repeat_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44566">
        <property type="entry name" value="TRANSDUCIN/WD40 REPEAT-LIKE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44566:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
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        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
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        <location>
            <begin position="202"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
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            <end position="289"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="441"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
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            <begin position="471"/>
            <end position="504"/>
        </location>
    </feature>
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            <begin position="1"/>
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    </feature>
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        <location>
            <begin position="108"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="108"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005002472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="504" mass="56141" checksum="AEBB3D945F19B8D9" modified="2022-01-19" version="1">MSSSLVAYDDSEPEAETEKADDFSTSRQGSLPSSANPVQHFAPGILSTKSTYETQLTENTDNFGMSVVCEDRPEHYALNNDSHLTSYSRRAYSSPTALCVPYKNYEQTLSSSRNSGNGASQKRTHTDSPTAPKGIRPYIPKRLRQENSSACEKKESDQSTSCDMKLDGPGEQAVRKISELIKPYLGSRYKLTEVPRSLIFHMSEHNGPVNAVQWCTVREQSHMLLSASMDKTIKVWDAVDTGGCLRTFSCHSCAVRAAQWSSCGRRILSGGFDSMLHLTDVETGKQIISSKNEFRISTLKFHPTDSNVFICGGFSPEVKAWDTRICKVTRVYKAAVQQTLDILFLPEGKEFLTSTDAVSRDSADRTIIAWDFQSAAKISNQIFHERYTCPSLALHPRESAFVAQTNGNYMALFSSQRPYRINKKKRYEGHKVEGFAVGCEFSPDGTLLVTGSSDGKVFFYNYHTSRIVRTLSAHREACVSAVFHPVLPSLLATSDWAGEIKIWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2STV3</accession>
    <name>A0A8C2STV3_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RNA-binding protein 34</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">RNA-binding motif protein 34</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">RBM34</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM RBM34 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2STV3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005005715.1">
        <property type="protein sequence ID" value="ENSCJPP00005003171.1"/>
        <property type="gene ID" value="ENSCJPG00005003409.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000011249"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12394">
        <property type="entry name" value="RRM1_RBM34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12395">
        <property type="entry name" value="RRM2_RBM34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000511">
        <property type="entry name" value="RNA binding motif protein 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000561">
        <property type="entry name" value="RNA-binding protein 34 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034221">
        <property type="entry name" value="RBM34_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF25">
        <property type="entry name" value="RNA-BINDING PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="RRM" evidence="14">
        <location>
            <begin position="217"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="14">
        <location>
            <begin position="320"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="185"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="396"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="441"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00075574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005003171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="460" mass="49855" checksum="F8C89A35607FFEF6" modified="2022-01-19" version="1">MSASQRTAHCVRPREVPPPLLHDGGAPRSRCSSRRVRYLALCPVPFPFPPLLPPRGRLAPRSGRCGATADAALLCRALCGDYVVGQVVGSLFSGGAAAVRPLAGLFRSAAPPPVVVAVPRVSAAQRDRGTGLEMSFFDIKRPVLSHQLQFSCLFLIREGALEQADEEEEQKLFESKAKQKKRAARAVAKSDGNAGTGRTVKQGKKKNEAEETVKNKRTVFVGNLPVSFTAQMLKSLFKEYGAIESIRFRSVVPAEDTVSRRLAAIKRKIHPNAKYINAYVVFKEENAAVKALQKNGAEVASGFHIRVDSASKDSSYDNKRSVFLGNLAYDISDSAVREHFADCGAVVAVRIVRDRQSGMGKGFGYVLFENTDAVHLALKLNNSELLGRKLRVKRCGEKDKAAQKSSTSGSGGRKDKAQHTAKSKRGSNDSFVGEKANPAKKSAKAKRLKSIAKKKGGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SU04</accession>
    <name>A0A8C2SU04_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Insulin-induced gene protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">INSIG1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Mediates feedback control of cholesterol synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the INSIG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SU04"/>
    <dbReference type="Ensembl" id="ENSCJPT00005005263.1">
        <property type="protein sequence ID" value="ENSCJPP00005002875.1"/>
        <property type="gene ID" value="ENSCJPG00005003151.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00580000081600"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032937">
        <property type="term" value="C:SREBP-SCAP-Insig complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008142">
        <property type="term" value="F:oxysterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140311">
        <property type="term" value="F:protein sequestering activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032869">
        <property type="term" value="P:cellular response to insulin stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006695">
        <property type="term" value="P:cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042632">
        <property type="term" value="P:cholesterol homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060363">
        <property type="term" value="P:cranial suture morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042472">
        <property type="term" value="P:inner ear morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042474">
        <property type="term" value="P:middle ear morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901303">
        <property type="term" value="P:negative regulation of cargo loading into COPII-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045541">
        <property type="term" value="P:negative regulation of cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045599">
        <property type="term" value="P:negative regulation of fat cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045717">
        <property type="term" value="P:negative regulation of fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070862">
        <property type="term" value="P:negative regulation of protein exit from endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006607">
        <property type="term" value="P:NLS-bearing protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045542">
        <property type="term" value="P:positive regulation of cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060021">
        <property type="term" value="P:roof of mouth development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032933">
        <property type="term" value="P:SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036316">
        <property type="term" value="P:SREBP-SCAP complex retention in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025929">
        <property type="entry name" value="INSIG_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15301">
        <property type="entry name" value="INSULIN-INDUCED GENE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15301:SF11">
        <property type="entry name" value="INSULIN-INDUCED GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07281">
        <property type="entry name" value="INSIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 12" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="10" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU241113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005002875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="231" mass="25360" checksum="7C87075F09CF7A38" modified="2022-01-19" version="1">MPRLERARGTLHGKERPLAAPHMQPIASAGRAVRDAAGCSATTWRQHLVQRSLVLFVVGAFMRNVTLFPDEVIATLFSSAWWVPPCCGTAAAVVGLLYPCIDSHLGEPHKFKREWASVMRCIAVFVGINHASAKLDFANNVQLSLTLAALSLGLWWTFDRSRSGLGLGITIAFVATLITQFLVYNGVYQYTSPDFLYIRSWLPCIFFSGGVTVGNIGRQLAMGIPEKPHND</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SUE9</accession>
    <name>A0A8C2SUE9_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SUE9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005005818.1">
        <property type="protein sequence ID" value="ENSCJPP00005003246.1"/>
        <property type="gene ID" value="ENSCJPG00005003471.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000235234"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061574">
        <property type="term" value="C:ASAP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052793">
        <property type="entry name" value="EJC-associated_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46589">
        <property type="entry name" value="APOPTOTIC CHROMATIN CONDENSATION INDUCER IN THE NUCLEUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46589:SF1">
        <property type="entry name" value="APOPTOTIC CHROMATIN CONDENSATION INDUCER IN THE NUCLEUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="1">
        <location>
            <begin position="32"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005003246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="83" mass="8627" checksum="3B2A2E35829CD6FC" modified="2022-01-19" version="1">ADAAVGHFRVGSSSAAAKMADGEEVTLDGRPLHLLRVADLKAALERRGLAKSGQKSALVKRLRGVSGDLMVKIRTEGKEGAAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SVD6</accession>
    <name>A0A8C2SVD6_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CWC15 spliceosome associated protein homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">CWC15</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWC15 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015707780.1">
        <property type="nucleotide sequence ID" value="XM_015852294.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015707781.1">
        <property type="nucleotide sequence ID" value="XM_015852295.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SVD6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005006645.1">
        <property type="protein sequence ID" value="ENSCJPP00005003819.1"/>
        <property type="gene ID" value="ENSCJPG00005003933.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107308425"/>
    <dbReference type="KEGG" id="cjo:107308425"/>
    <dbReference type="CTD" id="51503"/>
    <dbReference type="GeneTree" id="ENSGT00390000012084"/>
    <dbReference type="OrthoDB" id="30179at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006973">
        <property type="entry name" value="Cwf_Cwc_15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12718">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12718:SF2">
        <property type="entry name" value="SPLICEOSOME-ASSOCIATED PROTEIN CWC15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04889">
        <property type="entry name" value="Cwf_Cwc_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="52"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005003819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="230" mass="26619" checksum="57704A76794BCD6E" modified="2022-01-19" version="1">MTTAARPTFEPARGGRGKGEGDLSQLSKQYSSRDLPSHTKIKYRQATQDAPEEVRNRDFRRELEERERVAAREKSRDRPTREHTTSSSVSKKPRLDQIPAANLDADDPLTDEDDEDDDLEDSDDDDTAALLAELEKIKKERAEEQARKEQEQKAEEERIRMENILSGNPLLNLTGPAQPQANFKVKRRWDDDVVFKNCAKGIDETKKDKRFVNDTLRSEFHKKFMEKYIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SWC3</accession>
    <name>A0A8C2SWC3_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SWC3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005006877.1">
        <property type="protein sequence ID" value="ENSCJPP00005004002.1"/>
        <property type="gene ID" value="ENSCJPG00005004073.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155126"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005201">
        <property type="term" value="F:extracellular matrix structural constituent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043394">
        <property type="term" value="F:proteoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007044">
        <property type="term" value="P:cell-substrate junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007507">
        <property type="term" value="P:heart development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050991">
        <property type="entry name" value="ECM_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46708:SF7">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46708">
        <property type="entry name" value="TENASCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="52"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="140"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="233"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="332"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="421"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="524"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="524"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="537"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005004002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="579" mass="62613" checksum="AB58A38965C126B2" modified="2022-01-19" version="1">MTYERVLQGDVSSHVLDNLQEDREYSISIYAVYPQGPSQPVTALGRTLKLLPVKSILLQNETTDTLQARWSPVRGATGYRLTWTSADGSIQDVNLSSTYNYYMIQGLQPGTEYTVTINPIFGDVEGPVVSRKATTVASSTVQMLNVSEISTNGALVSWDSVAGATGYRVAWGPTPEFFGKDRPRQLALNKSITSYQLRNLAHDTEYVISLYVLFGSVEGPGITTSARTSPLGYISNFKVTSYTSSSLSLAWSAMLAATKFKVTWRPVGASNEKQVAKTQYLGSRLLAHRIDHLLPDTLYKVSIRAVFSKTEGPEVTLTHRTASLADSSPIHTIQDLRITNTDVNSLKLSWRRLPGATHYKISWVPFNGGLGTSHLVGAESNSFTIPKLKESTTYTIGVSAVIGGQEGNPTLLTAKTLDLPKVTEFTMQEAAETSVLLTWAAVPGASKYLLTWRLSSASDLSLEVLSAALRSYRVTGLSSEETYLFSIRPVFGDREGPETTLIGQTAGLHGDSPPPVSPMTSTKLATVRSPSPSNVRTTPLPLTTTTLPTTLLSSTTASATLTALPGPSECVSMCDFKVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SX71</accession>
    <name>A0A8C2SX71_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TPD52 like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">TPD52L2</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TPD52 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015737306.1">
        <property type="nucleotide sequence ID" value="XM_015881820.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SX71"/>
    <dbReference type="Ensembl" id="ENSCJPT00005007217.1">
        <property type="protein sequence ID" value="ENSCJPP00005004282.1"/>
        <property type="gene ID" value="ENSCJPG00005004290.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107323084"/>
    <dbReference type="CTD" id="7165"/>
    <dbReference type="GeneTree" id="ENSGT00940000155572"/>
    <dbReference type="OrthoDB" id="10000687at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007327">
        <property type="entry name" value="TPD52"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19307">
        <property type="entry name" value="TUMOR PROTEIN D52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19307:SF13">
        <property type="entry name" value="TUMOR PROTEIN D54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04201">
        <property type="entry name" value="TPD52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="176"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="182"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005004282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="205" mass="22139" checksum="A0A5F82995C873FF" modified="2022-01-19" version="1">MESASQDISLNSPNKGLLSDAMMDVPVDNAAAARTAAPEGLSAAEEEELRAEIAKVEEEIGTLRQVLAAKERHCGELKRKLGLTPLDGLKQNLSKSWHDVQVSNAYVRTSEKLGEWNDKVTQSDFYKKTQETLSQAGQKTSAALSNVGSVISRKLGDMRNSATFKSFEDRVGTIKSRVVGSRENSTDGLQSPSAGDKAPQDNAPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SXW8</accession>
    <name>A0A8C2SXW8_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tectonic family member 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">TCTN3</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="1">Part of the tectonic-like complex (also named B9 complex).</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SXW8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005007096.1">
        <property type="protein sequence ID" value="ENSCJPP00005004188.1"/>
        <property type="gene ID" value="ENSCJPG00005004209.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00570000079101"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007224">
        <property type="term" value="P:smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040354">
        <property type="entry name" value="TCTN1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011677">
        <property type="entry name" value="TCTN1-3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14611">
        <property type="entry name" value="TECTONIC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14611:SF4">
        <property type="entry name" value="TECTONIC-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07773">
        <property type="entry name" value="TCTN_DUF1619"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tectonic-1-3" evidence="2">
        <location>
            <begin position="154"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Tectonic-1-3" evidence="2">
        <location>
            <begin position="320"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005004188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="547" mass="60839" checksum="FD7E20570BB61917" modified="2022-01-19" version="1">SSGRVTGCVGSARIRTTLRPAAPLRRSDPARSRCSNERSLHPVTPLVFNKGKCNSARKYYSTDFCLGGSVCRSVNQVCVQKSLIFRANVPYRTATIAVSDGPDVFCVQLDNRKLTYFQQPKRLRGSDIQKLLQKFGRRSFSFSAQPHSRPASSAGDPILTYIDSLSVLSVLKQPVQLGVSGLCVDGNPAGFLESKSTSCARVLTDVIRSCTTDPALNAASYYQDLAVLKVPCFLLWLNNMEEISPIELPGTPYVTDNMCNNAVSEVMYEIEFNGTHGIQSVSVRFKVTSIAGSSVLSLQQRFTVRFWVSTRMLPHMLPRSGNPGYIAGAPLLIANSSMSVLRSEADGSCSQSLRHTVRFGSHMRTGCKLSNCSYIQLKLYEAFQGMDPAEHLARIRSARSTQEEEWVTILIQNCSVASLICNFSCLIPVTLDIQILWSKMGFLSNPQAQILGVRYFYRCQPLKVRDLKSFPYTHSVPLTTVVTFTELTEWPEPPRGLPKVHSKLPTDLFFPFKMALNIERTVKLLGMLWLYFLQVKLLGVVTVEVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SZ19</accession>
    <name>A0A8C2SZ19_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NDUFA4 mitochondrial complex associated like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">NDUFA4L2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2SZ19"/>
    <dbReference type="Ensembl" id="ENSCJPT00005007702.1">
        <property type="protein sequence ID" value="ENSCJPP00005004635.1"/>
        <property type="gene ID" value="ENSCJPG00005004555.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161040"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome LGE22C19W28_E50C23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010530">
        <property type="entry name" value="B12D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14256:SF5">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 4-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14256">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE MLRQ SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06522">
        <property type="entry name" value="B12D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005004635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="173" mass="18771" checksum="D3CE9DC287202DAF" modified="2022-01-19" version="1">MEGGVDGGLEVEGMEGGYRGDAEGMEGGWMWGCRGGLPFRPWRRMGLSCSTGFNAVGTSSHFSFGSQFLSSTRRFFSPSFNSVTPADSSAVLCSPGTASLCHIPPLVPLIGFISVGLGSAVLYLLRLALYSPDVSWDRKNNPEPWNKLGPTDQYKFIAVSTDYKNLKKERPSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2SZS8</accession>
    <name>A0A8C2SZS8_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MGAT4 family member C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MGAT4C</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein glycosylation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2SZS8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005008122.1">
        <property type="protein sequence ID" value="ENSCJPP00005004947.1"/>
        <property type="gene ID" value="ENSCJPG00005004780.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155352"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008375">
        <property type="term" value="F:acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006759">
        <property type="entry name" value="Glyco_transf_54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057279">
        <property type="entry name" value="MGAT4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056576">
        <property type="entry name" value="MGAT4_A/B/C_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12062:SF14">
        <property type="entry name" value="ALPHA-1,3-MANNOSYL-GLYCOPROTEIN 4-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12062">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYLTRANSFERASE VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04666">
        <property type="entry name" value="MGAT4_cons"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23524">
        <property type="entry name" value="MGAT4A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="MGAT4 conserved region" evidence="5">
        <location>
            <begin position="114"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="MGAT4 A/B/C C-terminal" evidence="6">
        <location>
            <begin position="388"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005004947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="528" mass="61433" checksum="4B59D6CA04C7D998" modified="2022-01-19" version="1">MPAASRWEPLISLPCEAQGPLELPAHTRRGQIEQNQLFSLCLVMLPYAFLHMRHNWKYFDKMRCLRKRSAVSFLGVLVICLLFMNLYIEDGYVLEGDKQLIRETATHQLNPERYAHTYKDLSNFSGSINISYRYLAGTPLPRKRYLTIGLSSVKRKKGNYLLETIKSIFEQSSYEELKEITVVVQLADFDSAWCDVMVQDISQKFAHHIIAGRLIVIHVPEEYYPILDGLKRNYNDPEDRVKFRSKQNVDYAFLLNFCANLSDYYVMLEDDVRCSKNFLTTVKKVITSREGSYWVTLEFSKLGYIGKLYHSHDLPRLAHFLLMFYQEMPCDWLLIHFRGLLAQKEVIRFKPSLFQHMGYYSSYKGAENKLKDDDFEEESFDVPDNPPANLHTNMNVFENYEASKAYSSIDEYFWGKPPSTGDFYGIVFEKPIKISKIKVVTGTEDRQNDILRHGALEVGEKIVGSKTGRKCTTYLRLGEFKNGNFEMTDVEHKVLFDISCMRILVTKSQKEWLIIRSISIWTSQTSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T098</accession>
    <name>A0A8C2T098_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Macrophage mannose receptor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">LOC107309030</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015708925.1">
        <property type="nucleotide sequence ID" value="XM_015853439.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005009147.1">
        <property type="protein sequence ID" value="ENSCJPP00005005679.1"/>
        <property type="gene ID" value="ENSCJPG00005005384.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107309030"/>
    <dbReference type="KEGG" id="cjo:107309030"/>
    <dbReference type="GeneTree" id="ENSGT01050000244842"/>
    <dbReference type="OrthoDB" id="6356110at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005537">
        <property type="term" value="F:D-mannose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23407">
        <property type="entry name" value="beta-trefoil_Ricin_MRC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="CDD" id="cd00062">
        <property type="entry name" value="FN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.10.10:FF:000001">
        <property type="entry name" value="Fibronectin 1a isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000032">
        <property type="entry name" value="macrophage mannose receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.100.10:FF:000014">
        <property type="entry name" value="Macrophage mannose receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.100.10:FF:000016">
        <property type="entry name" value="macrophage mannose receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.100.10:FF:000023">
        <property type="entry name" value="Macrophage mannose receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.100.10:FF:000031">
        <property type="entry name" value="macrophage mannose receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.100.10:FF:000022">
        <property type="entry name" value="Mannose receptor C-type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.100.10:FF:000025">
        <property type="entry name" value="Mannose receptor C-type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.100.10:FF:000030">
        <property type="entry name" value="Mannose receptor C-type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.100.10:FF:000027">
        <property type="entry name" value="Mannose receptor, C type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.10.10">
        <property type="entry name" value="Fibronectin, type II, collagen-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000562">
        <property type="entry name" value="FN_type2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036943">
        <property type="entry name" value="FN_type2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013806">
        <property type="entry name" value="Kringle-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24562">
        <property type="entry name" value="CysR_MRC2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00040">
        <property type="entry name" value="fn2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00013">
        <property type="entry name" value="FNTYPEII"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00059">
        <property type="entry name" value="FN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57440">
        <property type="entry name" value="Kringle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00023">
        <property type="entry name" value="FN2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51092">
        <property type="entry name" value="FN2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13 17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0430">Lectin</keyword>
    <keyword evidence="12 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 19" id="KW-0732">Signal</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034511747" description="Macrophage mannose receptor 1" evidence="19">
        <location>
            <begin position="19"/>
            <end position="1458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1395"/>
            <end position="1416"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-II" evidence="21">
        <location>
            <begin position="163"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="20">
        <location>
            <begin position="230"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="20">
        <location>
            <begin position="369"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="20">
        <location>
            <begin position="511"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="20">
        <location>
            <begin position="655"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="20">
        <location>
            <begin position="806"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="20">
        <location>
            <begin position="950"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="20">
        <location>
            <begin position="1100"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="20">
        <location>
            <begin position="1240"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="168"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="182"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00071860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005005679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1458" mass="166594" checksum="AA3129D40F298C5F" modified="2022-01-19" version="1">MAPGPLLLLLAFLPGAFPLLDTSTFLIYNEDHKRCVLALSSNSVTTAPCVQENESQKFRWVSDHQLMSISLKLCLGVPSKKDWVPITLYPCDKASELQRWECRNETLFAIQGEDLFFNYGNKQERNIMLYKGSGLWSRWKVYGTTDDLCSRGYEDTYTVRGNAEGAPCVFPFKFGNKWYADCTDAGRADGWFWCGTTADYDADKRYGFCPLKINSIDLLWNTDPLTNVQYQINSESALTWHQARKSCQQQKAELLSVTELHEQTYLAGLTSKLSSALWFGLNSLNFDSGWQWVGGAPFRYLNWVPGHPSPEPGKICAALNPGKVAKWENRECNQKLGYICKRGNATLASFIVPAETDVPIRCPDQWISYAGHCYIIHRDPKIWRDALTSCRKEDGDLASIHNVEEYSFVISQLGYKPDDELWIGLNDLKVQMYFEWSDGTPVTYAKWLRGEPTHANNRQEDCVVMKGKDGFWADHSCEKKIGYICKRKPLSEAPTEEEAIDMGCQRGWKRHGFYCYFIGNAFVTFSQANQTCERHQAYLATVQDRYEQAYLTSLVGLKTERYFWIGLSDVEEKGTFKWTNGEHVLFTHWNSEMPGRKPGCVAMRTGTAGGLWDVIKCEEKAKFVCKMWAEGVTPPPIPTTTPVPSCPEGWDSNNRISFCFKPFSKGEQKKTWLESQEFCRTIGGDLASINGKEEQYVIWRSIANNGFYHQHFWMGLYYLNPDDGFVWSDGSPVRYENWGFGEPNNYQGIELCAEISGDSSMLWNDRHCDYLYGWICQIRKGASLKPEPTESPVPKYVTTDDGWIINEDRHYYFSTESVPMEKGREFCKKNFGDLAVIESETERKFLWRYILKNGKEDAYFIGLQLSVDQRTSWMDGTPVNYLAWAPHEPNFANNDENCVVMYKNLGFWNDINCGYPNPYICERHNSSINSTVPSTTFSTPRGCNPTWLSFQNKCYKIFGSTEDERVTWHAARTACMNLGGNLATIPNEQVQAFLTFHMKDFPTDTWIGLNDINHELKFLWTDGRGVYFTNWAKGFPSGHVGSYSYDGQADCVVMRNNPVKEAGKWADESCDNNRGYICQIKADAEFLPSTTTDPTSIIRYGNSSYLFVHTKMNWEDARENCKRNQFDLSSILDPYSHSFLWLKILKYGVPIWIGLNSNVTNGRYEWIDNWRMKYTKWAEGEPKRKIGCVYLDISGAWKTGFCNESYFSVCKKPDVQAPTEPPQLPGKCPESEGHRSWIPFRGHCYYIESSSTRNWAQASLECLRLGASLVSVEDSAEASFLTYIIEPLEGKTSTFWTGMYRNVDGEWLWLDNTAVNFVNWNTGEPSPQQNEHCVEMYANSGYWNNIYCTSYKGYVCKKLKTTEILPSAEMPPAEMPTKAMTKDEEAPTLSHGKTGIVVIVVIIILAGSSLAGFLFYKRRKNRLSTNDSFENNLYFNSDGTGDTKDLVTNIERNEHATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T0R9</accession>
    <name>A0A8C2T0R9_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Microtubule actin crosslinking factor 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="Ensembl" id="ENSCJPT00005008483.1">
        <property type="protein sequence ID" value="ENSCJPP00005005176.1"/>
        <property type="gene ID" value="ENSCJPG00005003929.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155824"/>
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        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005882">
        <property type="term" value="C:intermediate filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045104">
        <property type="term" value="P:intermediate filament cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0051893">
        <property type="term" value="P:regulation of focal adhesion assembly"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0032886">
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    </dbReference>
    <dbReference type="GO" id="GO:0042060">
        <property type="term" value="P:wound healing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SPEC"/>
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        <property type="entry name" value="microtubule-actin cross-linking factor 1 isoform X2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="microtubule-actin cross-linking factor 1 isoform X2"/>
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        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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        </source>
    </evidence>
    <sequence length="2783" mass="313067" checksum="E684B01B99911E8F" modified="2022-01-19" version="1">MRINEQIDQGSKLNQLSKSTLGKGDGSTISSNGTLGASNVFESRAPEAKKLDERVIFDALKLSSDVSKPAPPPPRRRPNPERKENVNRRSWKSFMPPNFTEFAERMGASLSEVSEAGASNPSLRDKRDSSALLAEHGGHPDRSEPMSESLTLEHVSKSSGTTEAMQFAADSFGSATDERQPLLPAGDGHARATELARARLLPSATWPRTRKNFPKANLGDGRQETLEASESDCTVENVNLSPCLSEELLDAGLNILITTNLREKTESELRFEEDERWVMMEEWEEATLSERGKAVLVAEEKKSCCLADISEEREHFSAPEDSSAPSPGTAQPCSPRGDASSPIASSAHCTEDVAVQCEAEDFAAGLECSASPAIPELSDTDSVQMFLELEEQCLNEDEGDGAIPVLLGARFSPMDSEGLYPGLEKLTGAADEAREPTAPLEVSASDSAVVSDLEDFDVTCSSQVLSTMEPVTEPFSERDTLAITPTDSDGGTSPSPMATVGPGSSQQCLLALVEDAWGLPPTPQLHLRAVRQKVSLFQKEQVDPLQLKLQQVNGVGQGLIQSAGKNCDVQGLEHDMEEINTRWNTLNKKVAQRIAQLQEALLRCGKFQDALEPLLSWLTDTEELISNQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVEMIQAEGGRIAQSAEPADREKITGQLQSLESRWAALLCRAAGRQKQLEDILVLAKQFHETTEPVSDWLSVTEKKLANSEPIGTQTAKIQQQISRHKALEEDIEGHAADVAHVVHVGQGLSTLSCAAEQRLLAEKLDSLQGRYREVRERCCRKAALLEQALCNARLFGEEEVEVLNWLAEVEDKLGSVSVKDYKRDVLQKQHADQLALNEEIVNRKKNVDQAIRNGQALLKQTTGEEVLLIQEKLDGIKTRYSDITAASSKALRTLEQARQLATKFQSTHEELNAWMSKVEDELASSGGQSPASEQIPQFQQRQKELKKEVMEQRLVLDTVNEVSRALLELVPWRAREGLDKLVSDTNERYKLVSDTVRQRVEEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGAIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSQRNEIFGTCGEEQKAVLQEKTESLVQQYEAVSQLNSERYARLERAQVLVNQFWETYEELSPWIEETQALISQLPPPAIDHEQLKQQQEDMRQLRESIAEHKPHIDKLLKIGPQLKDLNPEEGEMVQKKYSTAEAMYAKIKEEVCQRALALDEAVSQSTQFHDKIEPMLETLEALSSRLRMPPLIPAEVDKIRECISENKNATVELEKLQPSFEALKRRGEELVGRSQGADKDLAAKVIQDKLDQMVFFWEDIKARAEEREMKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRLLGTDLIFACGETEKPEVKKSIDEMNNAWENLNKTWKERLEKLEEAMQAAVQYQDTLQAMFDWLDNAVIKLCNMSPVGTDLNTVKEQMNEMKEFKMEVYQQQIEMEKLNHQGELMLKKATDETDRDIIKEPLTELKHLWENLGEKIAHRQHKLEAALLALGQFQHALAELMAWLTHTEELLDAQKPINGDPKVIEVELAKHHVLKNDVLAHQATVETVNRAGNELLESSAGDDASSLRNRLEGLNACWEAVLQKTEEREQQLQSTLQQAQGFHGEIEDFLLWLTRMESQLSASKPTGGLPETAREQLNAHMELYGQLKAQEDVYSQLLAKGRLMLLNRDDSGSGSKTEQSVALLEQKWCLVSTKMEERKEALALATDFQNSLQDFINWLTLAEQSLNIVPPPSLILNAVMAQIDEHKVFANEVNAHRDRIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSVERGRALDDARKRAKQFHEAWKKLIDWLEDAENHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKALLPDDTQKLDNLLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIESSRDDTTWVKVQLQELSNRWDTVCKLSVSKQSRLEQALKQAEEFRTAVHMLLEWLSEAEQSLRFRGALPDDAEALQSLIDVHKEFMKKVEEKRVDVNAAVGMGEVILSACHPDCITTIKHWITIIRARFEEVLTWARQHQQRLEAALSELVANAELLEELLAWIQWAETTLIQRDQEPMPQNIDQVKALITEHQSFMEEMTRKQPDVDRVTKTYKRKATEPPHGALIDKSRSNRKSLTQAGPPTMPIISQSETKNPRINQLSARWQQVWLLALERQRKLNDALDRLEELKEFANFDFDVWRKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGILASKFPTTKLEMTAVADIFDRDGDGYIDYYEFVAALHPNKDAYRPTTDADKIEDEVTRQVAQCKCAKRFQVEQIGENKYRFFLGNQFGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCRARGRTNLELREKFILPEGASQGMTPFRSRGRRSKPSSRAASPTRSSSSASQSNHSCASMPSSPATPASGAKTPHHFSRCYDKPWLINSKAGTPLRGSDYPDLQLPSSEVTPAAGSKLKRPTFHSSRTSLVGDTSNSSSPVSSGAKSGRADPKKAASRPTSRAGSRTGSRASSRRGSDASDFDLLETQSACSDTSESSVAGSRRGAKPSKIPTMSKKTSTATPKTPGPKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T254</accession>
    <name>A0A8C2T254_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Gastrin/cholecystokinin type B receptor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Cholecystokinin-2 receptor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">CCKBR</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Receptor for gastrin and cholecystokinin. The CCK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T254"/>
    <dbReference type="Ensembl" id="ENSCJPT00005009289.1">
        <property type="protein sequence ID" value="ENSCJPP00005005790.1"/>
        <property type="gene ID" value="ENSCJPG00005005479.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286926"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004951">
        <property type="term" value="F:cholecystokinin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015054">
        <property type="term" value="F:gastrin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008188">
        <property type="term" value="F:neuropeptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017046">
        <property type="term" value="F:peptide hormone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031741">
        <property type="term" value="F:type B gastrin/cholecystokinin receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048565">
        <property type="term" value="P:digestive tract development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001696">
        <property type="term" value="P:gastric acid secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048732">
        <property type="term" value="P:gland development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045851">
        <property type="term" value="P:pH reduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007200">
        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007204">
        <property type="term" value="P:positive regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd15979">
        <property type="entry name" value="7tmA_CCK-BR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009126">
        <property type="entry name" value="Cholcskin_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000314">
        <property type="entry name" value="Gastrin_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24238">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24238:SF79">
        <property type="entry name" value="GASTRIN_CHOLECYSTOKININ TYPE B RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01822">
        <property type="entry name" value="CCYSTOKININR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00527">
        <property type="entry name" value="GASTRINR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 16" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0564">Palmitate</keyword>
    <keyword evidence="10 16" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 16" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 16 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="268"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="397"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="498"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="539"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="19">
        <location>
            <begin position="246"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="31"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="17">
        <location>
            <begin position="55"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="117"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005005790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="609" mass="65592" checksum="76A72C196150D471" modified="2022-01-19" version="1">MVWGEAGTPKAAAVGAASHPRGTPARPRLRAAQLQQTTWGAAQTAAGRSGRWLLGHGGICGERPGGAGGAGSSHPLESLELRSGPAAPPPPPPPPPPPPPPPPPLRSFFAAPRRPRPAPPRSPPPVPPPLTLSEAPKRARRRGAERSRRSPPVPSPVLPRRERWARGGCEGSAMDPRRLNESLQELLCRPGNGTGSANGTGTGPTWNGSACDLLRRGLRGPPAPKELDLTVRVLLYALIFVLSVCGNALVVAVLLLNRRLRTVTNSFLLSLALSDLMLALCCMPFTLIPNLMGTFIFGEAVCKLMAYLMGVSVSVSTFSLVAIAIERYSAICNPLQSRVWQTRSHACRVIASTWLFSALLMLPYAVYSTTRLLPVPGARPPLSQCTHAWPSEHVRQAWYVLLLLVLFFIPGVVMIVAYGLISRELYRGIRFELDIKGEAAAQRGSEPLPTCDEGDGCYLQLSRPGGALELRALGTAGAQQERARINSSEAKLVAKRRVIRMLVVIVAMFFLCWLPIFAANTWRAFAPRAAQRALSGAPISFIHLLSYTSACVNPIIYCFMNRRFRSAFLGTCAGCRRSCPRRAPDEDAANANASLSKFSYTTVSSLGPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T284</accession>
    <name>A0A8C2T284_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Odorant receptor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T284"/>
    <dbReference type="Ensembl" id="ENSCJPT00005009544.1">
        <property type="protein sequence ID" value="ENSCJPP00005005997.1"/>
        <property type="gene ID" value="ENSCJPG00005005655.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286912"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15951">
        <property type="entry name" value="7tmA_OR52R_52L-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000006">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050402">
        <property type="entry name" value="OR51/52/56-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26450:SF156">
        <property type="entry name" value="OLFACTORY RECEPTOR 52R1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26450">
        <property type="entry name" value="OLFACTORY RECEPTOR 56B1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0552">Olfaction</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="63"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="199"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="44"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005005997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="315" mass="35110" checksum="9AA72A9341B339DC" modified="2022-01-19" version="1">MSSVNSTGSSQPPTFFLLGIPGMEKEQFWIAFPFCIMYVIAVLGNIILLIVIKTESSLHEPMYLFLAMLAFTDLVLSTSMLPKMLAIFWRGSGEIGFISCLVQLFFVHNFTAVESGVLMAMALDRYFAICHPLRHSSILSMPVVAALGSLVLLRGVLMVSPACFLLRRKDFCHHRVISHSYCEHMAVVKMVCEDTRVNAAYGLFAAFAVMGFDLAVIAVSYTMILRVVLKLSASDTQLKAFNTCVSHVCVILAFYVSALFTVLTHRFGHSIPHQIHILVANIYLLLPPTLNPIIYGVRTKQLRDKIAVLFQRRGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T2G9</accession>
    <name>A0A8C2T2G9_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T2G9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005010330.1">
        <property type="protein sequence ID" value="ENSCJPP00005006568.1"/>
        <property type="gene ID" value="ENSCJPG00005006129.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00960000190059"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="205" mass="22408" checksum="0565CD481615BC40" modified="2022-01-19" version="1">MDTSKKRDEQLFCVGDCQDSQQGAVFIAAPIELLRANTLKRYWKNPLLCGCSSSLLSIPAAVRPSALSQAALPAPIAPILSLSGRCSRFRRVAHRSRRASRSDSSRVSTSPSRTGPFTLRMMERLPPARHYGPLTCVHCPWEPVRPSTLVTCGHRAARQNPDSPHPTPPARPRAPTLANLMGCTRLVSMAALTAGRRKAFRCSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T2Y0</accession>
    <name>A0A8C2T2Y0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA methyltransferase 10 homolog B</fullName>
            <ecNumber evidence="1">2.1.1.221</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">RNA (guanine-9-)-methyltransferase domain-containing protein 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">tRNA (guanine(9)-N(1))-methyltransferase TRMT10B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">TRMT10B</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">S-adenosyl-L-methionine-dependent guanine N(1)-methyltransferase that catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in tRNAs. Probably not able to catalyze formation of N(1)-methyladenine at position 9 (m1A9) in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>guanosine(9) in tRNA + S-adenosyl-L-methionine = N(1)-methylguanosine(9) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43156"/>
            <dbReference type="Rhea" id="RHEA-COMP:10367"/>
            <dbReference type="Rhea" id="RHEA-COMP:10368"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.221"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.1.1.221" evidence="1"/>
    <dbReference type="RefSeq" id="XP_015705560.1">
        <property type="nucleotide sequence ID" value="XM_015850074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T2Y0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005010503.1">
        <property type="protein sequence ID" value="ENSCJPP00005006711.1"/>
        <property type="gene ID" value="ENSCJPG00005006213.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107306733"/>
    <dbReference type="KEGG" id="cjo:107306733"/>
    <dbReference type="CTD" id="158234"/>
    <dbReference type="GeneTree" id="ENSGT00530000063169"/>
    <dbReference type="OrthoDB" id="278300at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome Z"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042721">
        <property type="term" value="C:TIM22 mitochondrial import inner membrane insertion complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052905">
        <property type="term" value="F:tRNA (guanosine(9)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002939">
        <property type="term" value="P:tRNA N1-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18100">
        <property type="entry name" value="Trm10euk_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028564">
        <property type="entry name" value="MT_TRM10-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038459">
        <property type="entry name" value="MT_TRM10-typ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047911">
        <property type="entry name" value="Trm10_B_MTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007356">
        <property type="entry name" value="tRNA_m1G_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563">
        <property type="entry name" value="TRNA (GUANINE-9-) METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563:SF19">
        <property type="entry name" value="TRNA METHYLTRANSFERASE 10 HOMOLOG B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51675">
        <property type="entry name" value="SAM_MT_TRM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase TRM10-type" evidence="12">
        <location>
            <begin position="32"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="235"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005006711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="271" mass="30453" checksum="D40E3472D8288234" modified="2022-01-19" version="1">MGWHSMVGYGMAGLPSLLCPAGAARQHSRAMVEERLLDARTSGPWLCIDLGLADYMTPKETSRLAAQIRRLYGANRQAEQPFWIYLTELVPGSPIHRECLRMNDGFSGYLMDTTQESYLDLFPLDAIVYLTPDSENVLEDIDPKKVYVLGGLVDESIHKNLTLQRAREQSLQTARLPIREYMVKSMNTKNYYSETLAINQVFDVLSTYYKTQSWPDALKAGVSSGKGYVLPDGEESVKTPQRDNTQENSLFPESLVQARAANCRFQAEAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T3B5</accession>
    <name>A0A8C2T3B5_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">PDZ and LIM domain 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">PDLIM5</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T3B5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005011603.1">
        <property type="protein sequence ID" value="ENSCJPP00005007495.1"/>
        <property type="gene ID" value="ENSCJPG00005006904.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155292"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031941">
        <property type="term" value="C:filamentous actin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051371">
        <property type="term" value="F:muscle alpha-actinin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007507">
        <property type="term" value="P:heart development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061061">
        <property type="term" value="P:muscle structure development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09453">
        <property type="entry name" value="LIM1_ENH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09457">
        <property type="entry name" value="LIM2_ENH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06753">
        <property type="entry name" value="PDZ_PDLIM-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000019">
        <property type="entry name" value="LIM domain binding 3 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000014">
        <property type="entry name" value="PDZ and LIM domain protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000020">
        <property type="entry name" value="PDZ and LIM domain protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050604">
        <property type="entry name" value="PDZ-LIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24214:SF32">
        <property type="entry name" value="PDZ AND LIM DOMAIN PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24214">
        <property type="entry name" value="PDZ AND LIM DOMAIN PROTEIN ZASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0440">LIM domain</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PDZ" evidence="9">
        <location>
            <begin position="10"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="8">
        <location>
            <begin position="439"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="8">
        <location>
            <begin position="498"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="309"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="312"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="356"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="393"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005007495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="639" mass="68856" checksum="AF77761A3C746D66" modified="2022-01-19" version="1">MSNYSVSLVGPAPWGFRLQGGKDFNMPLSISRIRTLFGSCYSGSLQLNDGGKAARAQVGIGDVVLTIDGISTDGMTHLEAQNKIKACTGNLNMTLQRVATATKPDLIHVPKGEPKEVVKPVPVASAAAPKVTAMASVAYNKTPRPFGVVASTKVTSIPSPSSAFTPAQAAPMLPTPAPFAAPGLHVNAKPNANGRLPTPSTAKPAVNVPRQPGTHNAAPGGHVGDGTQELAEGLRRGFRENQGDNKQQNGKIPPKRPPRKHIVDTYTEFYHTPTHSDASKKRLIEDTEDWHPRTGTTQSRSFRILAQITGTDHMKEPEHEGAKKSNDSMESTPPATYTTTSVKNVSASHECPDPRPTSTNNATSPSVPKPTGPSSGAKYSGWQPPSQAAPASGWTSNSIKSGTSGTTAPSQKFDATSQLTEQDTLVQRAEHIPAGKRTPMCAQCNQVIRGPFLVALGKSWHPEEFNCAHCKTSMAYIGFVEEKGALYCEVCYEKFFAPECSKCQRKILGEVINALKQTWHVSCFVCVACHNPIRNNVFHLEDGDPYCETDYYALFGTLCHGCEFKIDAGDRFLEALGFSWHDTCFVCAVSKAVLLFKQTHGGSTCANLTGMGVRAKMPFSPQNPNKKHFHSYLEGMLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T5I4</accession>
    <name>A0A8C2T5I4_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Synaptotagmin 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">SYT14</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Is Ca(2+)-independent.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Can also form heterodimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the synaptotagmin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T5I4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005012782.1">
        <property type="protein sequence ID" value="ENSCJPP00005008432.1"/>
        <property type="gene ID" value="ENSCJPG00005007527.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159420"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08389">
        <property type="entry name" value="C2A_Synaptotagmin-14_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08408">
        <property type="entry name" value="C2B_Synaptotagmin-14_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000153">
        <property type="entry name" value="Synaptotagmin 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000062">
        <property type="entry name" value="synaptotagmin-14 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043541">
        <property type="entry name" value="SYT14/14L/16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46129">
        <property type="entry name" value="SYNAPTOTAGMIN 14, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46129:SF3">
        <property type="entry name" value="SYNAPTOTAGMIN-14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="7">
        <location>
            <begin position="557"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="7">
        <location>
            <begin position="712"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="237"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="456"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="519"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="13"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="245"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00056709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00063654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005008432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="871" mass="94960" checksum="31AB9717A08F69E3" modified="2022-01-19" version="1">MRETKDLRQVGSPCPPSCPSPSPSPFPSPFPPPCPSPCPSPCPSPGPSPGPSPCPFPCPPSCPSPCPSPCPSSSPSPCPSPCHLPAHLPAHLLAHLPAHLPSISLPTSLPTSLPISQPISHTISQPISLPISLPISLPISLPISFPISHTISQPISFPISHTISQPISQPISLPISQPISLPTSLPISFPISLPTSLPISLPISLPISHLPSGRSRCALTGARISRSVAAARARARAVCRGRSPAPRPAPPTRPPHTPHPAPLHPRPAPRVAPVWQTRRSAAPLLRALQLVRPTAGIMAIDGGERTCGVHELICIRKVSPEAIGFLSAVGVFIVLMLLLFLYINKKMCFENVGGFPDLDSGYPTRKNSQDKLYNSYMSKDQHGSSSESEDEALGKYHEALSRTQSSRLPVVDGRQQKNYVWETRQKYSPLSAEYDGYSSEASIDEANCIQRMRRTPPLDELQPPPYQDDSGSPHLSCTPSEVGDGKCEFSQCSNSPRCSYKCPSEGSTGHEIESFHNKGYEEDVPSDSTAVLSPEDMSARGSSSQLPKPFDPEPEAKYGTLDVTFDYDSQEQKLLVTVTAVTDIPTYSRTGGSSWQVHLVLLPIKKQRAKTSIQRGPCPVFTETFKFNHVESEMIGNYAVRFRLYSVRRMKKERIVGEKIFHLTKLNLQGKMSVPVILEPSYSLSGCDSQMSMSEVSCSESTSSCQSLVHGSAPEILVGLLYNATTGRLSAEVIKGSHFKNLAANRPPNGLFCCLKHLIGGQVYIIRDTYVKLTLLNSMGQEMSKCKTSIRRGQPNPVYKETFVFQVALFQLSDVTLILSVYNKRSMKRKEMIGWISLGLNSSGEDELNHWTEMKESKGQQVLLCKIMYGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T691</accession>
    <name>A0A8C2T691_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Annexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ANXA6</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">May associate with CD21. May regulate the release of Ca(2+) from intracellular stores.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Melanosome</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">A pair of annexin repeats may form one binding site for calcium and phospholipid.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the annexin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015731366.1">
        <property type="nucleotide sequence ID" value="XM_015875880.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T691"/>
    <dbReference type="Ensembl" id="ENSCJPT00005011735.1">
        <property type="protein sequence ID" value="ENSCJPP00005007602.1"/>
        <property type="gene ID" value="ENSCJPG00005006964.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107320219"/>
    <dbReference type="KEGG" id="cjo:107320219"/>
    <dbReference type="CTD" id="309"/>
    <dbReference type="GeneTree" id="ENSGT00940000158770"/>
    <dbReference type="OrthoDB" id="37886at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034704">
        <property type="term" value="C:calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042470">
        <property type="term" value="C:melanosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048306">
        <property type="term" value="F:calcium-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015485">
        <property type="term" value="F:cholesterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097190">
        <property type="term" value="P:apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051560">
        <property type="term" value="P:mitochondrial calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051283">
        <property type="term" value="P:negative regulation of sequestering of calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006937">
        <property type="term" value="P:regulation of muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009888">
        <property type="term" value="P:tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000001">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000002">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000003">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000004">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000013">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.10">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001464">
        <property type="entry name" value="Annexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018502">
        <property type="entry name" value="Annexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018252">
        <property type="entry name" value="Annexin_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037104">
        <property type="entry name" value="Annexin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002393">
        <property type="entry name" value="ANX6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502">
        <property type="entry name" value="ANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502:SF19">
        <property type="entry name" value="ANNEXIN A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00191">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00196">
        <property type="entry name" value="ANNEXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00202">
        <property type="entry name" value="ANNEXINVI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00335">
        <property type="entry name" value="ANX"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47874">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00223">
        <property type="entry name" value="ANNEXIN_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51897">
        <property type="entry name" value="ANNEXIN_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0041">Annexin</keyword>
    <keyword evidence="6 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="8 10" id="KW-0111">Calcium/phospholipid-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005007602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="672" mass="75288" checksum="37FFF7FFB13C353D" modified="2022-01-19" version="1">MAPKGKVYRGSVKDFPGFNASQDADALYNAMKGFGSDKDAILDLITSRSNKQRVEICQAYKSQYGKDLIADLKYELTGKFERLIVSLMRPPAYSDAKEIKDAIAGIGTDEKCLIEILASRTNQEIHDLVAAYKDAYERDLEADIVGDTSGHFKKMLVVLLQGAREEDDVVSEDLVEQDAKDLLEAGEQKWGTDEAQFIFILGRRSKQHLRMVFDEYLKISGKPIERSIRGELSGDFEKLMLAVVKCVRSTAEYFAERLYKAMKGLGTRDNTLIRIMVSRSEIDMLDIREVFRTKYEKSLHNMIKEDTSGEYKKALLKLCGGDDDAAGEFFPEAAQVAYRMWELSAVAKVELRGTVQPADNFNDDGDAQVLRKAMKGLGTDEGAIIEVLTQRSNAQRQQILKAYKAHYGRDLMADLKSELSGSLAKLILGLMLTPAQYDAKQLRKAVEGAGTDESTLIEIMATRNNQEIAAINEAYQQAYHKSLEDDLSSDTSGHFKRILVSLALGNRDEGPENLAQAQEDAKVVAETLKLADVASNDSSDSLETRFLSILCTRSYPHLRRVFQEFIKMTNHDVEHAIRKRMSGDVRDAFVAIVRSVKNKPAFFADKLYKSMKGAGTDERTLTRIMISRSEIDLLNIRGEFIDLFDKSLHHMIEKDTSGDYRKALLALCGGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T715</accession>
    <name>A0A8C2T715_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Purkinje cell protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">PCP4</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PCP4 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015738336.1">
        <property type="nucleotide sequence ID" value="XM_015882850.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2T715"/>
    <dbReference type="SMR" id="A0A8C2T715"/>
    <dbReference type="Ensembl" id="ENSCJPT00005014074.1">
        <property type="protein sequence ID" value="ENSCJPP00005009412.1"/>
        <property type="gene ID" value="ENSCJPG00005008270.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107323579"/>
    <dbReference type="CTD" id="5121"/>
    <dbReference type="GeneTree" id="ENSGT00530000064267"/>
    <dbReference type="OrthoDB" id="9944346at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905291">
        <property type="term" value="P:positive regulation of CAMKK-AMPK signaling cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045666">
        <property type="term" value="P:positive regulation of neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052142">
        <property type="entry name" value="Calmodulin_Regulator_PCP4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15359:SF7">
        <property type="entry name" value="CALMODULIN REGULATOR PROTEIN PCP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15359">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005009412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="62" mass="6821" checksum="6CED2578E41BF287" modified="2022-01-19" version="1">MSERQGTGATNGKDKTSGENDGQKKVQEEFDIDMDAPETERAAVAIQSQFRKFQKKKAGSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2T9J3</accession>
    <name>A0A8C2T9J3_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Glutamate receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">GRID2</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Member of the ionotropic glutamate receptor family, which plays a crucial role in synaptic organization and signal transduction in the central nervous system. Although it shares structural features with ionotropic glutamate receptors, does not bind glutamate as a primary ligand. Promotes synaptogenesis and mediates the D-Serine-dependent long term depression signals and AMPA receptor endocytosis of cerebellar parallel fiber-Purkinje cell (PF-PC) synapses through the NRX1B-CBLN1-GRID2 triad complex. In the presence of neurexins and cerebellins, forms cation-selective channels that are proposed to be gated by glycine and D-serine. However, recent research disputes this ligand-gated cation channel activity. Cation-selective ion channel activity can be triggered by GRM1 in Purkinje cells.</text>
    </comment>
    <comment type="function">
        <text evidence="22">Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>Na(+)(in) = Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:34963"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14 22">Postsynaptic cell membrane</location>
            <topology evidence="14 22">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRID2 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2T9J3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005015346.1">
        <property type="protein sequence ID" value="ENSCJPP00005010342.1"/>
        <property type="gene ID" value="ENSCJPG00005009021.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155192"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043197">
        <property type="term" value="C:dendritic spine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008328">
        <property type="term" value="C:ionotropic glutamate receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098688">
        <property type="term" value="C:parallel fiber to Purkinje cell synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098839">
        <property type="term" value="C:postsynaptic density membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030165">
        <property type="term" value="F:PDZ domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097110">
        <property type="term" value="F:scaffold protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904315">
        <property type="term" value="F:transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021707">
        <property type="term" value="P:cerebellar granule cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060079">
        <property type="term" value="P:excitatory postsynaptic potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904861">
        <property type="term" value="P:excitatory synapse assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007157">
        <property type="term" value="P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900454">
        <property type="term" value="P:positive regulation of long-term synaptic depression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051965">
        <property type="term" value="P:positive regulation of synapse assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060134">
        <property type="term" value="P:prepulse inhibition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043523">
        <property type="term" value="P:regulation of neuron apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010975">
        <property type="term" value="P:regulation of neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099151">
        <property type="term" value="P:regulation of postsynaptic density assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099072">
        <property type="term" value="P:regulation of postsynaptic membrane neurotransmitter receptor levels"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099538">
        <property type="term" value="P:synaptic signaling via neuropeptide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035249">
        <property type="term" value="P:synaptic transmission, glutamatergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd13731">
        <property type="entry name" value="PBP2_iGluR_delta_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000024">
        <property type="entry name" value="Glutamate receptor, ionotropic, delta 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000068">
        <property type="entry name" value="Glutamate receptor, ionotropic, delta 1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000045">
        <property type="entry name" value="Glutamate receptor, ionotropic, delta 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000040">
        <property type="entry name" value="Glutamate receptor, ionotropic, delta 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001508">
        <property type="entry name" value="Iono_Glu_rcpt_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00177">
        <property type="entry name" value="NMDARECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 22" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="21" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 22" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 22" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 22" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 22" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="9 22" id="KW-0675">Receptor</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="6 22" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 22" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="577"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="609"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="646"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="841"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="23">
        <location>
            <begin position="452"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="24">
        <location>
            <begin position="462"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="535"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="540"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="752"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="site" description="Crucial to convey clamshell closure to channel opening" evidence="20">
        <location>
            <position position="675"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with the cone snail toxin Con-ikot-ikot" evidence="20">
        <location>
            <position position="702"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="21">
        <location>
            <begin position="93"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="21">
        <location>
            <begin position="766"/>
            <end position="821"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00036239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00056512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00061411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU367118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005010342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1017" mass="113996" checksum="C78D6807DA6EDF49" modified="2022-01-19" version="1">MRVGRDLRDHRVQPPGFESLCCRAALLPLAPQGDSNTWAPVLQRGIPATATPGQKSLFFSLRFSQASFSLYLLCPPFCNPGADPDPQPYLCSCDLMNQGILALVSSIGCTSAGSLQSLADAMHIPHLFIQRSSGGTPRSSCGLTRSNRNDDYTLSVRPPVYLNDVILRVITEYAWQKFIIFYDNDYDIRGIQEFLDRVSQQGMDVALQKVENNINKMITGLFATMRIEELNRYRDTLRRAILVMNPLTAKSFLTEVVETNLVAFDCHWIIINEEISDLDVQELVRRSIGRLTIIRQTFPVPQNISQRCFRGNHRISSSLCDPKDPFSQSMEISNLYIYDTVLLLANAFHKKLEDRKWHSMASLTCIRKNSKPWQGGRSMLETIKKGGVNGLTGELEFAENGGNPNVHFEILGTNYGEDLGRGIRKLGCWNPITGLNGSLTDRKLENNMRGVVLRVVTVLEEPFVMVSENVLGKPKKYQGFSIDVLEALANYLGFKYEIYVAPDHKYGSPQDDGSWNGLIGELVFKRADIGISALTITPDRENVVDFTTRYMDYSVGVLLRKAEKTVDMFACLAPFDLSLWACIAGTVLLVGLLVYLLNWLNPPRLQMGSMTSTTLYNSMWFVYGSFVQQGGEVPYTTLATRLMMGAWWLFALIVISSYTANLAAFLTITRIENSIQSLQDLSRQTDIPYGTVLDSAVYEHVRVKGMNPFERDSMYSQMWRMINRSNGSENNVLESTAGIQKVKHGNYAFVWDAAVLEYVAINDGDCSFYTVGNTVADRGYGIALQHGSPYRDVFSQRILELQQNGDMDILKHKWWPKNGQCDFYSSVDTKQKGGALDIKSFAGVFCILAAGIVLSCFIAMLETWWNKRKGSRVPSKEDDKEIDLEHLHRRVNSLCTDDDSPHKQFSTSSIDLTPLDIDTLPTRQALEQISDFRNTHITTTTFIPEQIQTLSRTLSAKAASGFSFGSVPEHRTGPFRHRAPNGGFFRSPIKTMSSIPYQPTPTLGLNLGSDPDRGTSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TB36</accession>
    <name>A0A8C2TB36_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Trace amine associated receptor 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">TAAR5</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TB36"/>
    <dbReference type="Ensembl" id="ENSCJPT00005015130.1">
        <property type="protein sequence ID" value="ENSCJPP00005010169.1"/>
        <property type="gene ID" value="ENSCJPG00005008906.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161258"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990081">
        <property type="term" value="F:trimethylamine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050890">
        <property type="term" value="P:cognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007606">
        <property type="term" value="P:sensory perception of chemical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000030">
        <property type="entry name" value="trace amine-associated receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050569">
        <property type="entry name" value="TAAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009133">
        <property type="entry name" value="TAAR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009132">
        <property type="entry name" value="TAAR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249">
        <property type="entry name" value="HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249:SF307">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01831">
        <property type="entry name" value="TRACEAMINE1R"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01830">
        <property type="entry name" value="TRACEAMINER"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="47"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005010169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="334" mass="37746" checksum="ADF92528518ACF1C" modified="2022-01-19" version="1">ISSNDEGMLITLCYEVNGSCHRTLHPFGVQLAIYLACALGTLITVLGNLLVVIVVSHFQALHTPTNFLLLSLALADMLLGLTVLPFSTIRSVESCWYFGDDFCKLHTFLDTLFCLTSIFHLCFISIDRHCAICNPLLYPTKFTLKVACMCIGVGWAVPMVYTSVFLYTKEIAEGLGHFLQDVPCVGSCQLLFNKLWGWLNFPVFFFPCLIMIALYVKIFTVANKQARLINSMNKSFGAHLHRRASRSERRAAKTLGVAVGIYLLCWLPFTIDTMVDSLLNFITPPVLFDILIWFAYFNSACNPLIYVFSYHWFRKAVKLVLTQGIFCSREHIQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TCR3</accession>
    <name>A0A8C2TCR3_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">TLE family member 4, transcriptional corepressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">TLE4</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat Groucho/TLE family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TCR3"/>
    <dbReference type="SMR" id="A0A8C2TCR3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005015933.1">
        <property type="protein sequence ID" value="ENSCJPP00005010829.1"/>
        <property type="gene ID" value="ENSCJPG00005009372.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234519"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome Z"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990907">
        <property type="term" value="C:beta-catenin-TCF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140297">
        <property type="term" value="F:DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990830">
        <property type="term" value="P:cellular response to leukemia inhibitory factor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000001">
        <property type="entry name" value="transducin-like enhancer protein 3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005617">
        <property type="entry name" value="Groucho/TLE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009146">
        <property type="entry name" value="Groucho_enhance"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10814">
        <property type="entry name" value="TRANSDUCIN-LIKE ENHANCER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10814:SF31">
        <property type="entry name" value="TRANSDUCIN-LIKE ENHANCER PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03920">
        <property type="entry name" value="TLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01850">
        <property type="entry name" value="GROUCHOFAMLY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="4 10" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Groucho/TLE N-terminal Q-rich" evidence="13">
        <location>
            <begin position="24"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="549"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="591"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="673"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="110"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="158"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="191"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="249"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="266"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="293"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005010829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="749" mass="81169" checksum="88E12DE2B81F2FAB" modified="2022-01-19" version="1">MIRDLSKMYPQTRHPAPHQPAQPFKFTISESCDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSYGLNIEMHKQAEIVKRLNAICAQVIPFLSQEQQQLQAQHLSHGHGLPVPLTPHPSGLQPPAIPPIGSSAGLLALSSALGGQSHLPIKDEKKHHDNDHQRDRDSIKSSSVSPSASFRTAEKHRNSTDYSSESKKQKTEEKEIAARYDSDGEKSDDNLVVDVSNEDPSSPRGSPAHSPRENGLDKTRLLKKDAPISPASIASSSSTPSSKSKELSLNEKSTTPVSKSNTPTPRTDAPTPGSNSTPGLRPVPGKPPGVDPLASGLRTPMAVPCPYPTPFGIVPHAGMNGELTSPGAAYAGLHNISPQMSAAAAAAAAAAAYGRSPVVGFDPHHHMRVPGIPPNLTGIPGGKPAYSFHVSADGQMQPVPFPPDALIGPGIPRHARQINTLNHGEVVCAVTISNPTRHVYTGGKGCVKVWDISHPGNKSPVSQLDCLNRDNYIRSCRLLPDGRTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIFSLGYCPTGEWLAVGMENSNVEVLHVTKPDKYQLHLHESCVLSLKFAHCGKWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISVDDKYIVTGSGDKKATVYEVIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TF27</accession>
    <name>A0A8C2TF27_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Zinc finger MIZ-type containing 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ZMIZ1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015721828.1">
        <property type="nucleotide sequence ID" value="XM_015866342.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TF27"/>
    <dbReference type="Ensembl" id="ENSCJPT00005018494.1">
        <property type="protein sequence ID" value="ENSCJPP00005012813.1"/>
        <property type="gene ID" value="ENSCJPG00005010877.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107315718"/>
    <dbReference type="CTD" id="57178"/>
    <dbReference type="GeneTree" id="ENSGT01030000234539"/>
    <dbReference type="OrthoDB" id="27975at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046332">
        <property type="term" value="F:SMAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061665">
        <property type="term" value="F:SUMO ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030521">
        <property type="term" value="P:androgen receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048844">
        <property type="term" value="P:artery morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090398">
        <property type="term" value="P:cellular senescence"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048589">
        <property type="term" value="P:developmental growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003007">
        <property type="term" value="P:heart morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048146">
        <property type="term" value="P:positive regulation of fibroblast proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045747">
        <property type="term" value="P:positive regulation of Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045582">
        <property type="term" value="P:positive regulation of T cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021852">
        <property type="term" value="P:pyramidal neuron migration to cerebral cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060395">
        <property type="term" value="P:SMAD protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007179">
        <property type="term" value="P:transforming growth factor beta receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001570">
        <property type="term" value="P:vasculogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007296">
        <property type="term" value="P:vitellogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000012">
        <property type="entry name" value="Zinc finger MIZ domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057847">
        <property type="entry name" value="ZMIZ1/ZMIZ2_GBD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040797">
        <property type="entry name" value="ZMIZ1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782">
        <property type="entry name" value="ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782:SF7">
        <property type="entry name" value="ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25527">
        <property type="entry name" value="GBD-like_ZMIZ1_ZMIZ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02891">
        <property type="entry name" value="zf-MIZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18028">
        <property type="entry name" value="Zmiz1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51044">
        <property type="entry name" value="ZF_SP_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SP-RING-type" evidence="10">
        <location>
            <begin position="707"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="112"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="248"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="336"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="848"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="383"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="419"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="437"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="490"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="848"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="862"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="931"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1016"/>
            <end position="1043"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005012813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1043" mass="113138" checksum="842705B46FA5E9B6" modified="2022-01-19" version="1">MNSMDRHIQQTNDRLQCIKQHLQNPANFHNAATELLDWCGDPRAFQRPFEQSLMGCLTVVSRVAAQQGFDLDLGYRLLAVCAANRDKFTPKSAALLSSWCEELGRLLLLRHQKSRQNDPPGKLPMQPPMNSMSSMKPTLSHSDGSFPYDSVPWQQNTNQPPGSLSVVTTVWGVTNTSQSQVLGNPMANANNPMNPGGNPMASGMTTSNPGINSPQFAGQQQQFSAKAGSTQPYIQQGMYGRPNYPGSGGFGGSYPGGPNTPAGMGIPPHTRPPADFTQPAAAAAAAAVAAAAATATATATATVAALQETQNKDMNQYGPVCSSFQMGPTQAYNNQFMNQPGPRGPASMPGNMNPASMGAGMTPSSMSGPPMGMNQPRPPGMSPFSTHGQRMPQQAYPGPRPQSLPIQGIKRPYPGEPNYGNQQYGPNSQFPNQPGQYPTPNPPRPLTSPNYPGQRMPSQQSTGQYPPPTVNMGQYYKPSRPVPVANYPHSPVPGNPTPPMTPGSNIPPYLSPNQDVKPPFPPDIKPNINALPPPPTNHNDELRLTFPVRDGVVLEPFRLEHNLAVSNHVFHLRPTVHQTLMWRSDLELQFKCYHHEDRQMNTNWPASVQVSVNATPLTIERGDNKTSHKPLHLKHVCQPGRNTIQITVTACCCSHLFVLQLVHRPSVRSVLQGLLKKRLLPAEHCITKIKRNFSSVAASSGNATLNGEDGVEQTAIKVSLKCPITFRRIQLPARGHDCKHVQCFDLESYLQLNCERGTWRCPVCNKTALLEGLEVDQYMWGILNAIQNSEFEEVTIDPTCSWRPVPIKSDIHIKDDPDGIPSKRFKTMSPSQMIMPNVMEMIAALGPGPSPYPSLPPPPGSNNSTEYGNQGNSYQGHGNFDFPHGNPGGTSMNDFMHGPQLSHPPDMPSSMAALDKPLSHPMQESIPHPGSTDQSHTSMQQGLHVPHPSSQSGQPLHHSGPPSQQSRQPPPAASGNHPHSDLTFNPSSALEGQAGGQGAPDMPEPSLDLLPELTNPDELLSYLDPPDLPSNSNDDLLSLFENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TFG2</accession>
    <name>A0A8C2TFG2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Guanine nucleotide-binding protein subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">GNA11</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="18">G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the G-alpha family. G(q) subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015742148.1">
        <property type="nucleotide sequence ID" value="XM_015886662.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TFG2"/>
    <dbReference type="SMR" id="A0A8C2TFG2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005016578.1">
        <property type="protein sequence ID" value="ENSCJPP00005011336.1"/>
        <property type="gene ID" value="ENSCJPG00005009735.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107325609"/>
    <dbReference type="KEGG" id="cjo:107325609"/>
    <dbReference type="CTD" id="2767"/>
    <dbReference type="GeneTree" id="ENSGT00940000161033"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071467">
        <property type="term" value="P:cellular response to pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904888">
        <property type="term" value="P:cranial skeletal system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048066">
        <property type="term" value="P:developmental pigmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0086100">
        <property type="term" value="P:endothelin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007507">
        <property type="term" value="P:heart development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990806">
        <property type="term" value="P:ligand-gated ion channel signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060158">
        <property type="term" value="P:phospholipase C-activating dopamine receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007207">
        <property type="term" value="P:phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007208">
        <property type="term" value="P:phospholipase C-activating serotonin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032024">
        <property type="term" value="P:positive regulation of insulin secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008217">
        <property type="term" value="P:regulation of blood pressure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045634">
        <property type="term" value="P:regulation of melanocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001501">
        <property type="term" value="P:skeletal system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000002">
        <property type="entry name" value="guanine nucleotide-binding protein G(Q) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003977">
        <property type="entry name" value="Guanine nucleotide-binding protein G(q) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000692">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000654">
        <property type="entry name" value="Gprotein_alpha_Q"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF328">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00442">
        <property type="entry name" value="GPROTEINAQ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 16 18" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9 17 18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 17 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 16 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0564">Palmitate</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 18" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="49"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="155"/>
            <end position="156"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="180"/>
            <end position="186"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="205"/>
            <end position="209"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="274"/>
            <end position="277"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU369122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005011336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="359" mass="42058" checksum="B9E16427169BE1AE" modified="2022-01-19" version="1">MTLESMMACCLSDEVKESKRINAEIEKQLRRDKRDARRELKLLLLGTGESGKSTFIKQMRIIHGSGYSEEDKKGFTKLVYQNIFTAMQSMIRAMETLKILYKYEQNKANAVLIREVDVEKVMTFEQPYVSAIKTLWNDPGIQECYDRRREYQLSDSAKYYLSDVDRIATPGYLPTQQDVLRVRVPTTGIIEYPFDLENIIFRMVDVGGQRSERRKWIHCFENVTSIMFLVALSEYDQVLVESDNENRMEESKALFRTIITYPWFQNSSVILFLNKKDLLEDKILYSHLVDYFPEFDGPQRDAQAAREFILKMFVDLNPDSDKIIYSHFTCATDTENIRFVFAAVKDTILQLNLKEYNLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TFI0</accession>
    <name>A0A8C2TFI0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine/threonine-protein kinase mos</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Oocyte maturation factor mos</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">MOS</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
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        <property type="nucleotide sequence ID" value="XM_015855594.2"/>
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    <dbReference type="AlphaFoldDB" id="A0A8C2TFI0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005017733.1">
        <property type="protein sequence ID" value="ENSCJPP00005012218.1"/>
        <property type="gene ID" value="ENSCJPG00005010406.1"/>
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    <dbReference type="GeneID" id="107310179"/>
    <dbReference type="KEGG" id="cjo:107310179"/>
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    <dbReference type="GeneTree" id="ENSGT00940000160233"/>
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        <property type="component" value="Chromosome 2"/>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:protein serine/threonine kinase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0051296">
        <property type="term" value="P:establishment of meiotic spindle orientation"/>
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        <property type="term" value="P:oocyte maturation"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:positive regulation of ERK1 and ERK2 cascade"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:regulation of meiotic nuclear division"/>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="STKc_Mos"/>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
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    </dbReference>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
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        <property type="entry name" value="Ser/Thr_kinase_AS"/>
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    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF285">
        <property type="entry name" value="V-MOS MOLONEY MURINE SARCOMA VIRAL ONCO HOMOLOG"/>
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        <property type="entry name" value="Pkinase"/>
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    </dbReference>
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        <property type="entry name" value="S_TKc"/>
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    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="83"/>
            <end position="364"/>
        </location>
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        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>ATP</name>
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        <source>
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    </evidence>
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</entry>
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        <name evidence="6" type="primary">SH2D5</name>
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            <taxon>Archosauria</taxon>
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            <taxon>Saurischia</taxon>
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            <taxon>Coelurosauria</taxon>
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            <taxon>Galliformes</taxon>
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        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
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                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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        <scope>IDENTIFICATION</scope>
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            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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            <end position="123"/>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="387" mass="42460" checksum="318DAEB66067B258" modified="2022-01-19" version="1">MKKKTTGNGRGLDLAPPPPRTRGITKPAEYVGSFMVEELELQQHAGQLEDQLQALKDCPRRRSVVLRFSLQGLKVYGADGETLLMAHALRRILYSTCLHAECQFAFVARNPHSPPSALFCHLFVGPPGETHVLHLLLCRSFQICYLQAHPELQAAEPDPPVLLREPLNPEEVSRTVNALLSLRRLPALGPLGAGERRAEAEGRAVGWRPGNPYCSPVLVRKKAIRSKVLRSGAYRDCGAESTLQQREGAPSGGESRGMRGLVLFPDTEAALAESVWAFAGIARADGIALLHRDVLGAFLLRPEPGGTPRWCLWVRVPCGVVPYCVLRTLQGRFCVEHSHAEFRSLPALLAHYSAVPGSCFCRLSAGRRNPGYERDEDGAALLQHERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2THM5</accession>
    <name>A0A8C2THM5_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized LOC107314652</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="primary">LOC107314652</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
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            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
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            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_015719607.1">
        <property type="nucleotide sequence ID" value="XM_015864121.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2THM5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005018300.1">
        <property type="protein sequence ID" value="ENSCJPP00005012668.1"/>
        <property type="gene ID" value="ENSCJPG00005010755.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107314652"/>
    <dbReference type="KEGG" id="cjo:107314652"/>
    <dbReference type="GeneTree" id="ENSGT00390000015769"/>
    <dbReference type="OrthoDB" id="9931800at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040439">
        <property type="entry name" value="FAM237A/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36690">
        <property type="entry name" value="PROTEIN FAM237A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36690:SF2">
        <property type="entry name" value="PROTEIN FAM237A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034282365" evidence="1">
        <location>
            <begin position="35"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005012668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="185" mass="21446" checksum="09B2CF97EF8CAD59" modified="2022-01-19" version="1">MDFGNRGRIHCNMRLTYFLLVMGMFCLTPSLCHSQIDPLALGRADPQCWESSSAVLLEMRKPHISDSVSGFWDFMIFLRSSENLKHGALFWDLAQLFWDIYVDCVLSRTHGLGRRQLAEAQQRITTLASQFTGRNQGMFTHIQRSPVLRKRDLFEDLIKKHKHKSRSMLLGRIIGELGEKKKQHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TIG1</accession>
    <name>A0A8C2TIG1_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transmembrane protein 178B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC107314802</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM178 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015719958.1">
        <property type="nucleotide sequence ID" value="XM_015864472.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TIG1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005018429.1">
        <property type="protein sequence ID" value="ENSCJPP00005012754.1"/>
        <property type="gene ID" value="ENSCJPG00005010844.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107314802"/>
    <dbReference type="KEGG" id="cjo:107314802"/>
    <dbReference type="GeneTree" id="ENSGT00390000015299"/>
    <dbReference type="OrthoDB" id="9941453at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004031">
        <property type="entry name" value="PMP22/EMP/MP20/Claudin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039625">
        <property type="entry name" value="T178A/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32005:SF3">
        <property type="entry name" value="SI:CH211-150G13.3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32005">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 178B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13903">
        <property type="entry name" value="Claudin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034108121" evidence="9">
        <location>
            <begin position="29"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="45"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005012754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="291" mass="31464" checksum="90CA8F487E5E2749" modified="2022-01-19" version="1">MAAAAQALSGAGLLLAAAALALLAVAIGTDSWYETDARRHRERCRGFGHKRSDPPGSMSAPSSHLPLRARPPRALLPGRPPAPAPAAAAAALDSHCGRRFNSTVSGLWRRCHRAGYEPDSEELIRKGVIQRCTAVKYHYTSSSLPRNLPVNITNTIRQDEWHALHLRRMTAGFIGMAVSIILFGWIIGVLGCCKQQELMQYVAGLLFLMGGTCCIISLCTCVAGINFELSRYPRYVYGLPEDISHGYGWSMFCAWGGLGLTLLAGFLCTLAPSLNTSRASVQKPRQENGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TJ41</accession>
    <name>A0A8C2TJ41_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heme-binding protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC107315490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HEBP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TJ41"/>
    <dbReference type="Ensembl" id="ENSCJPT00005020866.1">
        <property type="protein sequence ID" value="ENSCJPP00005014687.1"/>
        <property type="gene ID" value="ENSCJPG00005012232.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000164539"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.80.10:FF:000007">
        <property type="entry name" value="Heme-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="entry name" value="Regulatory factor, effector binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006917">
        <property type="entry name" value="SOUL_heme-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11220">
        <property type="entry name" value="HEME-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11220:SF7">
        <property type="entry name" value="SOUL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04832">
        <property type="entry name" value="SOUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="Probable bacterial effector-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005014687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="246" mass="28517" checksum="0C88A9084D9A88F5" modified="2022-01-19" version="1">MAEESPDSAYHSHGSSLEEEAAERMDDEEQERLLSYWQSVGRGHQVDVPRDMAEPIQQLTRNNSPQERQSIPFTLIQRKEKLGDLLYEKRQYGKAKWACIKMKEKQYEQSICLGFMKLMRYICEQNSSGLYLGITIPIVTIVHTNESQSEMRQAVTVAYYLPEVLQDQPPHPFDSDIIIEEWPSTIVYSRSFRGITNEDSIMREINLLAEILESPELCLQDTFIIAGYTNPAAANRHNEIWFLQRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TJ82</accession>
    <name>A0A8C2TJ82_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA damage-binding protein 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Damage-specific DNA-binding protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">DDB2</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat DDB2/WDR76 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TJ82"/>
    <dbReference type="Ensembl" id="ENSCJPT00005020552.1">
        <property type="protein sequence ID" value="ENSCJPP00005014440.1"/>
        <property type="gene ID" value="ENSCJPG00005012054.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00510000047881"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030054">
        <property type="term" value="C:cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031464">
        <property type="term" value="C:Cul4A-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031465">
        <property type="term" value="C:Cul4B-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090734">
        <property type="term" value="C:site of DNA damage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051865">
        <property type="term" value="P:protein autoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006290">
        <property type="term" value="P:pyrimidine dimer repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000161">
        <property type="entry name" value="DNA damage-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033312">
        <property type="entry name" value="DDB2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15169">
        <property type="entry name" value="DAMAGE-SPECIFIC DNA BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15169:SF0">
        <property type="entry name" value="DNA DAMAGE-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7 15" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="15">
        <location>
            <begin position="222"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="422"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005434"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014580"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
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    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
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    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
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            <dbReference type="ARBA" id="ARBA00023204"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031670"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005014440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="471" mass="52902" checksum="C2D4BF4A62C108E8" modified="2022-01-19" version="1">MAPVNRPKDKKHEKAHERQSEEAKSSGKRKLDYEGQQNVPLTKKLLLRKNKAQEKIGNVSSGIVSTLSSEIFRDPYKSYHSLLSFPFDRRVTCLEWHPTHPSTVAVGSKGGDIILWDYEVLTKTCFIKGKGPGDSLGGMKFSPYESAKLYVASGDGTLSLQDLEGKLVQVISRAPDCGHENHNVCCWYCSVDVSASCRAVVTGDNLGNVVLLSTSGEEIWKLKLHKKKVTHVEFNSRCEWLLATASVDQTVKIWDLRNIKNKANFLHVLPHDKPVNAAYFSPTDGAKLLSTDQRNEIRVYSCSDWTKPQHLIPHPHRHFQHLTPIKATWHPRYDLIVVGRYPDPNFPGYTAHELRTVDIFDGNTGEMVCQLYDSNASGIISLNKFNPMGDTLASGMGYNILIWSREEMVMKKQEHLLKAMTEQGIGSRSLSRRGRQRQANPGTSKLKAKLLFCEVEETGTKAKDSKSQGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TKQ9</accession>
    <name>A0A8C2TKQ9_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Zona occludens protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Zonula occludens protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">TJP1</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell junction</location>
            <location evidence="3">Gap junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Tight junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MAGUK family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSCJPT00005021725.1">
        <property type="protein sequence ID" value="ENSCJPP00005015305.1"/>
        <property type="gene ID" value="ENSCJPG00005012700.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155164"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005921">
        <property type="term" value="C:gap junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045216">
        <property type="term" value="P:cell-cell junction organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090557">
        <property type="term" value="P:establishment of endothelial intestinal barrier"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905605">
        <property type="term" value="P:positive regulation of blood-brain barrier permeability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0150105">
        <property type="term" value="P:protein localization to cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06727">
        <property type="entry name" value="PDZ1_ZO1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06728">
        <property type="entry name" value="PDZ2_ZO1-like_ds"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06729">
        <property type="entry name" value="PDZ3_ZO1-like_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12026">
        <property type="entry name" value="SH3_ZO-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000009">
        <property type="entry name" value="Putative tight junction protein ZO-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000013">
        <property type="entry name" value="Putative tight junction protein ZO-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.220.30:FF:000004">
        <property type="entry name" value="tight junction protein ZO-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000110">
        <property type="entry name" value="tight junction protein ZO-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000170">
        <property type="entry name" value="tight junction protein ZO-1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005417">
        <property type="entry name" value="ZO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005418">
        <property type="entry name" value="ZO-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035597">
        <property type="entry name" value="ZO-1_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000906">
        <property type="entry name" value="ZU5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13865">
        <property type="entry name" value="TIGHT JUNCTION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13865:SF25">
        <property type="entry name" value="TIGHT JUNCTION PROTEIN ZO-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00791">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01597">
        <property type="entry name" value="ZONOCCLUDNS"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01598">
        <property type="entry name" value="ZONOCCLUDNS1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51145">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0965">Cell junction</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0303">Gap junction</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 15" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="5" id="KW-0796">Tight junction</keyword>
    <feature type="domain" description="PDZ" evidence="19">
        <location>
            <begin position="23"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="19">
        <location>
            <begin position="187"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="19">
        <location>
            <begin position="420"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="17">
        <location>
            <begin position="515"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate kinase-like" evidence="18">
        <location>
            <begin position="689"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="domain" description="ZU5" evidence="20">
        <location>
            <begin position="1637"/>
            <end position="1758"/>
        </location>
    </feature>
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        <location>
            <begin position="115"/>
            <end position="191"/>
        </location>
    </feature>
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            <end position="396"/>
        </location>
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        <location>
            <begin position="825"/>
            <end position="946"/>
        </location>
    </feature>
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        <location>
            <begin position="1098"/>
            <end position="1595"/>
        </location>
    </feature>
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        <location>
            <begin position="123"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="314"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="329"/>
            <end position="338"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="878"/>
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        <location>
            <begin position="892"/>
            <end position="905"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="935"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1104"/>
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        <location>
            <begin position="1116"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1168"/>
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        </location>
    </feature>
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        <location>
            <begin position="1200"/>
            <end position="1212"/>
        </location>
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        <location>
            <begin position="1230"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1284"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1350"/>
            <end position="1361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1400"/>
            <end position="1413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1416"/>
            <end position="1433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1449"/>
            <end position="1459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1515"/>
            <end position="1535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1541"/>
            <end position="1550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00077377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00081594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1758" mass="196881" checksum="5435A13A2284D87D" modified="2022-01-19" version="1">MSARAASSKSATMEETAIWEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVLKGGPAEGLLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRMKKIQIPVARQEPEPVSENEDDSYDEEIRDPRTSRGAASSNRRHEKSWVRDRSASRERSLSPRSDRRSVTSSQPAKPTKVTLVKSRKNEEYGLRLASHIFVKEISQDSLAARDGNIQEGDVVLKINGTVTENMSLADAKTLIERSKGKLKMVVQRDERATLLNVPDLSDSIHSANASERDDISEIQSLASDHSNRSHDRPRRSRSRSPDQRSEPSDHSRHSPQQPSNGSLRSREDERATKPGAVSTPVKNADDISKTMEEVAVERTEKQTPPLPEPKPVYAQGGQPDVDLPVSPSDGPLPNSTHEDGMLRPSMKLVKFRKGDSVGLRLAGGNDVGIFVAGVLEDSPAAKEGLEEGDQILRVNNVDFTNIIREEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGDSFYIRTHFEYEKESPYGLSFNKGEVFRVVDTLYNGKLGSWLAIRIGKNHKEVERGIIPNKNRAEQLASVQYTLPKTAGGDRADFWRFRGLRSSKRNLRKSREDLSAQPVQTKFPAYERVVLREAGFLRPVTIFGPIADVAREKLAREEPDIFQIAKSEPRDAGTDQRSSGIIRLHTIKQIIDRDKHALLDVTPNAVDRLNYAQWYPIVVFLNPDSKQGVKTMRMRLCPESRKSARKLYERAHKLRKNNHHLFTTTINLNSMNEGWYGALKEAIQQQQNQLVWVSEGKADGATSDDLDLHDDRLSYLSAPGSEYSMYSTDSRHTSDYEDTDTEGGAYTDQELDETLNDEVGTPPESAITRSSEPVREDSSGMHHETQTYTGYASQAQPQPNLRIDSSGFKTAASQPKAEASPAVPYLSPSPESNPATSSTSAVNANVNLTNVRLEEPTAAPYNSYQPQAGPLRTSSTEGAHVVLRDQEPSSLPPHIDPAKVYRKDPYVSEEASRQSYVLKQPAVNHPVQRQERDPNLIYESQTQYAEKQPSRDYEQSTYRYDSTNYVDQFSRGYDPRLHYEDRVPPYEEHWSYYDEKQPYNQPRTAYESQPPRDLDSRQNTEESTERSYYPAQPRFEEPPPMSYDGRPRYEHAPKNFSLPQVRYEDQHPVGYDTHAHGRYKQEAQPYQSAISRSPEPKQYFDPHMRGYEQGPPQAYNAKAGQFEPSHSTSSVSLPPPASSQTKPEVLPSNSKPLPTPPSLAEEEEDPAMKPQSVRSRVKIFERRRSPSLEKMKDPSDTSVVKPPELAPKPTLPAMSGPKPTSQSQYEHDKTTYRAPEPQRPQVKPPEDIVRSNHYDPEEDEEYYRKQLSYFDRRNFENKPSAQVPASHHSDSTKPIHSQNQLNFSNYSKGKPTDAESMDRSVGDKRYEPIPQVTTPPPAPSVQYTQPQSINSPVLSLPAHHKPALSEVNSVSDPPPPQNKPAIFRSSREDTVQSTFYPQKSFPDKGPVNGTEQVQKTVTPSYNRFTTKPYTSAARPFERKFESPKFNHNLLPNEAQHKPELPSKSPNSPQPILKAHSSSQPPEFDSGMDTYSVQVDKPKYQPNNVNAVPKAIPVSPSALEDEEEEDGHTVVATARGVFNSNGGVLSSIETGVSIIIPQGAIPEGIEQEIYFKVCRDNSILPPLDKEKGETLLSPLVMCGPHGLKFLKPVELRLPHCASMTPDGDPKTWQNKSLPGDPNYLVGANCVSVLIDHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TKU1</accession>
    <name>A0A8C2TKU1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphorylated adapter RNA export protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">RNA U small nuclear RNA export adapter protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">PHAX</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PHAX family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015705133.1">
        <property type="nucleotide sequence ID" value="XM_015849647.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TKU1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005021780.1">
        <property type="protein sequence ID" value="ENSCJPP00005015341.1"/>
        <property type="gene ID" value="ENSCJPG00005012740.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107306455"/>
    <dbReference type="KEGG" id="cjo:107306455"/>
    <dbReference type="CTD" id="51808"/>
    <dbReference type="GeneTree" id="ENSGT00390000011084"/>
    <dbReference type="OrthoDB" id="20573at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome Z"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140262">
        <property type="term" value="F:mRNA cap binding complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043489">
        <property type="term" value="P:RNA stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006408">
        <property type="term" value="P:snRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1440:FF:000001">
        <property type="entry name" value="phosphorylated adapter RNA export protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1440">
        <property type="entry name" value="PHAX RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039047">
        <property type="entry name" value="PHAX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019385">
        <property type="entry name" value="PHAX_RNA-binding_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038092">
        <property type="entry name" value="PHAX_RNA-binding_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13135">
        <property type="entry name" value="CYTOSOLIC RESINIFERATOXIN BINDING PROTEIN RBP-26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13135:SF0">
        <property type="entry name" value="PHOSPHORYLATED ADAPTER RNA EXPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10258">
        <property type="entry name" value="PHAX_RNA-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Phosphorylated adapter RNA export protein RNA-binding" evidence="12">
        <location>
            <begin position="235"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="399" mass="45380" checksum="ACF9155D0A584194" modified="2022-01-19" version="1">MALEVRRMDGDVEDGELSDSDSDMPGAGSPRERQKKSFDGGNAGRPFQSSISSGAQDVPYRTTKSVDSSDESFSESDDDSCLWKRKRQKCFNLPPAKSEPFTFNQSHAKQTAQGGKKVNNIWGMVLQEQNQDAVATELGILGMDGSIDRSRQSETYNYLLAKKLMKEAQQKEAETLDKELDEYMHDDKKTLPAEEENGQGFLKRKRSVKDRLGERQEMKYKGRYEITEEDSEEKVADEIAYRLCEPKKDLIARVVKIIGKRKAIELLMETAEVEQNGGLFIVNGTRRRTPGGVYLNLLKNTPSVKEEQIKEIFYLENQKEYENKKAAKKRRIQVLGKKMKKAIKGLNLQEYDDASRETFASDTNEALASLDDLQDGHHETKMEPEDIIEIDNAHDLEIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TPJ7</accession>
    <name>A0A8C2TPJ7_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC107312327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_032299368.1">
        <property type="nucleotide sequence ID" value="XM_032443477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TPJ7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005022300.1">
        <property type="protein sequence ID" value="ENSCJPP00005015786.1"/>
        <property type="gene ID" value="ENSCJPG00005013034.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107312327"/>
    <dbReference type="KEGG" id="cjo:107312327"/>
    <dbReference type="GeneTree" id="ENSGT01040000240860"/>
    <dbReference type="OrthoDB" id="9382832at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.360.10">
        <property type="entry name" value="Antimicrobial Peptide, Beta-defensin 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034892601" evidence="1">
        <location>
            <begin position="23"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="62" mass="7003" checksum="882B695E57C7AD87" modified="2022-01-19" version="1">MKLLCVLFAVLLLFSMAVPGYGQYEGACKGFCASVCGKRDEWTFRRFCKNKYCCLPPPKKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TQ18</accession>
    <name>A0A8C2TQ18_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rho GTPase-activating protein 30-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ARHGAP30</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TQ18"/>
    <dbReference type="Ensembl" id="ENSCJPT00005023857.1">
        <property type="protein sequence ID" value="ENSCJPP00005017071.1"/>
        <property type="gene ID" value="ENSCJPG00005013971.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161411"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051576">
        <property type="entry name" value="PX-Rho_GAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15729">
        <property type="entry name" value="CDC42 GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15729:SF12">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="123"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="255"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="123"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="161"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="322"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="385"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="404"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="463"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="483"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="554"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="567"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="621"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="637"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005017071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="669" mass="70858" checksum="022CA4678C3917E7" modified="2022-01-19" version="1">MRSRDIEATGFNGTAAFMEVRVQSIVVEFILTHVEQLFGDAPLCGTVPVTPLPPLGTEALRSSRLFPIDGSGPYNVPAALSQGDGPPPIRPYHTIIELSEHRRKGSLKAKKWKSIFHLGRSDAKRKLGKAEDKEEKCGKLSLRPAKSMDSLSSVPYSSDGEGGHEAPRQLRHLLLPEKLTEEPRGPESESESSTKSEPTTPRPGRVMAAGTRSRAEKCAGVHISGPFSVTVPLHITSNLSRLTRGQHCPALAQHGAVGSLPSTRHRTKEPDPPQDNEGERRGQRPHGAGRPGESPVEQPASYLSIEECTDEDMFYMAPSGSDTEEPPGDTDSDDMFLSAHDELSPLAADPETPPSSAAMGERGAEPQDGNPPPEPCPAEEADLGDGGHLEDHYGDTAEGGGQVLEKEEGDGGDREGSDGWSRAQLGLQGEDGEVMDPGGEEGKDGAAKQSGEGDPQPSEGSVLPEGPLQEPTEPLLPQEAVPEAPPAPLAGDPPTPMLVQGDPPTPMMVQGDPPTPIMVQEDPPTPMLAQGDPPTPVSAPEVPEDPPTPAAIKECTDPPPERHHPALTPPPPPRAAPDPLLPALPPPAGTSPPHPVPCSAMTAAPRFAWRSRSVRVQQRPLRARVSKASVRHRCPTPHAPRPPAAPRPPPLNAGRSSWRSPAAVSLDAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TQP3</accession>
    <name>A0A8C2TQP3_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ankyrin repeat domain 13D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ANKRD13D</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Late endosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TQP3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005022456.1">
        <property type="protein sequence ID" value="ENSCJPP00005015903.1"/>
        <property type="gene ID" value="ENSCJPG00005013126.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182928"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140036">
        <property type="term" value="F:ubiquitin-modified protein reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002091">
        <property type="term" value="P:negative regulation of receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000057">
        <property type="entry name" value="Ankyrin repeat domain-containing protein 13B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021832">
        <property type="entry name" value="ANKRD13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055285">
        <property type="entry name" value="ANKRD13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12447">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12447:SF2">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 13D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11904">
        <property type="entry name" value="ANKRD13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="47"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Ankyrin repeat" evidence="10">
        <location>
            <begin position="163"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="538"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="542"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF11904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005015903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="603" mass="67199" checksum="441B27E1DC9F9D29" modified="2022-01-19" version="1">GSRGHGAGMARAADTFPLHRLVWHNRHQALDSALRSGTHDVELTDPRGRTPLHLATTLGHLESVRVLLRHNANVGRENANGWTVLQEAVSTGDPEIVQLVLQYRDYQRATRRLAGIPELLSKLRRASDFYVEMKWEFTSWVPLVSKVCPSDVYRVWKRGESLRVDTTLLGFEHMTWQRGRRSYIFKGEEEGAVVMEVDHDKQVVYTETLALALHEPDLLLAAMQPSEEHVAGRLTSPIVSTHLDTRNIAFERNKSGIWGWRSEKMEVVSGYEAKVYSASNVELVTKTRTEHLSDQDKSRSKGSRTPFHSFLGLAQQHSTHNGAPAPPAASPTNPTAITLEEYFDPHFDLEARNIGRPIEVSSKVQRFKATLWLCEEHPLSLAEQVAPIIDLMAISNAHFAKLRDFITLKLPPGFPVKIEIPLFHVLNARITFSNLCGCDQPLGSVRVCNPTQPPGARAVEPAVFEVPPGYTVMGAGRSEPLREDEDDLLQFAIQQSLLEAGSETEQVTVWEALTNARPGPRPPPYDEELQLERCVRLRPRGPRSAPSGPAFAARRSPSPGSSRSGSTARRRCGPAGSRRGGSGPVSVSVRLYLLWRPFFFNLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TSS8</accession>
    <name>A0A8C2TSS8_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein S100-A14-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC107324459</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TSS8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005024084.1">
        <property type="protein sequence ID" value="ENSCJPP00005017255.1"/>
        <property type="gene ID" value="ENSCJPG00005014119.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161706"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048306">
        <property type="term" value="F:calcium-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042379">
        <property type="term" value="F:chemokine receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071624">
        <property type="term" value="P:positive regulation of granulocyte chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090026">
        <property type="term" value="P:positive regulation of monocyte chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032496">
        <property type="term" value="P:response to lipopolysaccharide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034142">
        <property type="term" value="P:toll-like receptor 4 signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05022">
        <property type="entry name" value="S-100A13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013787">
        <property type="entry name" value="S100_Ca-bd_sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11639:SF4">
        <property type="entry name" value="PROTEIN S100-A14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11639">
        <property type="entry name" value="S100 CALCIUM-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01023">
        <property type="entry name" value="S_100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01394">
        <property type="entry name" value="S_100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034020940" evidence="3">
        <location>
            <begin position="20"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="S100/CaBP-9k-type calcium binding subdomain" evidence="4">
        <location>
            <begin position="467"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005017255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="547" mass="59014" checksum="1A8467F5A5A8E20D" modified="2022-01-19" version="1">MVPGAWCIAPGAQCMVCSAWCIVPGAQCMVPGAQCMVPGAQCMVHGIRYMLHGIQCMVHGTRCMVHCSWCSMHAMQCMVHGTWCLVHGSLCMVLSAWCIVPGAQCMVPGAQCMVPSALCMVPGAWCMVSIAWCMAPGAQCMVPSALCMVPGAWCMVSIAWCIVLGAQCMAPGAQCMVPSAWYMVPGAQCLAPGAQCMVPGAQCMVPGAQCMAPGAQCMVPGAQCMVPSALCMVPGAWCIVPGAHYMVPGSCCMAPRAHITVPITRCPVPGAGSHAALHGHAGWEKLSVWPCRRRFPAPRWPWARLPNEPPCTTPCRELPLTPPQYKAPQQLNASTAGTALAAGKWPGLSLRDEGGGWGVSSYPRVRHPPLQSPSHARFCRDLQGRSHPRDVSRQLGASQGVFLAPALKEGKSPLNPTLIADIFPHPPSSSTPRPPHPKQRDCRPRRSNMGQCNCRKKRKDSQELTDVERAIETVINQFHCYAVKGQKEYLTPNEMRELVVQKLPHLGKCVGPLDEKIECMGDPDEAKLEFGEYWDMMGDAAKGCRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TT04</accession>
    <name>A0A8C2TT04_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Solute carrier family 41 member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">SLC41A1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Acts as a magnesium transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SLC41A transporter family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TT04"/>
    <dbReference type="Ensembl" id="ENSCJPT00005025678.1">
        <property type="protein sequence ID" value="ENSCJPP00005018445.1"/>
        <property type="gene ID" value="ENSCJPG00005015022.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183042"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061768">
        <property type="term" value="F:magnesium:sodium antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071286">
        <property type="term" value="P:cellular response to magnesium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010961">
        <property type="term" value="P:intracellular magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.20:FF:000001">
        <property type="entry name" value="Solute carrier family 41 member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.20:FF:000002">
        <property type="entry name" value="Solute carrier family 41, member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.20">
        <property type="entry name" value="SLC41 divalent cation transporters, integral membrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006667">
        <property type="entry name" value="SLC41_membr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036739">
        <property type="entry name" value="SLC41_membr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045349">
        <property type="entry name" value="SLC41A1-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16228">
        <property type="entry name" value="DIVALENT CATION TRANSPORTER SOLUTE CARRIER FAMILY 41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16228:SF23">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 41 MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01769">
        <property type="entry name" value="MgtE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161093">
        <property type="entry name" value="MgtE membrane domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="216"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="288"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="446"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="475"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="516"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="SLC41A/MgtE integral membrane" evidence="11">
        <location>
            <begin position="141"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="SLC41A/MgtE integral membrane" evidence="11">
        <location>
            <begin position="388"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="63"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU369007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005018445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="548" mass="58820" checksum="0A35CDDA2EAE9799" modified="2022-01-19" version="1">MSSKQEQKETHQANGAVLPAVPMDCLVSPDRGQLVEPSSFLGPDGVGVEVVVLESRANAKGVREEDALLENGSQSNESDDTSTDRGPEPASPLKETSFSIGLQVLFPFLLAGFGTVAAGMVLDIVQHWDVFKYVTEVFILVPALLGLKGNLEMTLASRLSTAANIGQMDTPKELWKMITGNMALIQVQATVVGFLASIAAVIFGWIPDGHFSLDHAVLLCASSVATAFIASLVLGRISIMYILHAPLPDMLGSPCLHPNFFLFYFAVGMIMIGVIIGSRKMGINPDNVATPIAASLGDLITLALLSGISWGLYKELGSKAYVNPLVCAFFIALLPIWIIIAKKNAATREVLYSGWEPVIIAMAISSVGGLILDRTVSDPNFAGMAVFTPVINGVGGNLVAVQASRISTYLHMSGMPGESPETTPRKCPSPCSTFFSSDVNSRSARVLFLLVVPGHLVFLYTISSMQGGHTTLTPIFIVFYMTAALLQVLILLYIADWMVHWMWGRDLDPDNFSIPYLTALGDLIGTGLLALSFHVLWLIGDRDSDVGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TT71</accession>
    <name>A0A8C2TT71_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transmembrane protein 81</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">TMEM81</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Essential fertilization factor required for male fertility. Part of a conserved trimeric sperm complex with the essential fertilization factors IZUMO1 and SPACA6 which bridges sperm and oocyte membranes during fertilization by binding to IZUMO1R/JUNO on the oocyte.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TT71"/>
    <dbReference type="Ensembl" id="ENSCJPT00005025533.1">
        <property type="protein sequence ID" value="ENSCJPP00005018318.1"/>
        <property type="gene ID" value="ENSCJPG00005014924.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000006349"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035036">
        <property type="term" value="P:sperm-egg recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039293">
        <property type="entry name" value="TMEM81"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35670">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35670:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034104265" description="Transmembrane protein 81" evidence="12">
        <location>
            <begin position="25"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="13">
        <location>
            <begin position="97"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005018318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="251" mass="27926" checksum="76EA32E82669395C" modified="2022-01-19" version="1">MKTFRNGFILGMMLLGLSCLPLEASIPQVTIPAELQSVEAEVAVNSTSCSVTCGLGLQIEEMCEVTPSGERKNCTTRRSHCTTTWGCGLLHFTIPVGKPFVLSCLSSDVINFGLRGYSCTWKVASGLITMNDLLFVPFRNPDYTVVFSPAKESDAGTYRCDVRVLKTFRVIKRIYFGVRVIRDDMVNLDFVKSLTEEQKLAIRKQEGMEANSTLIDLEEQQYFWQKKLFHRYSIGLGVGLVGVIVVRLGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TTE0</accession>
    <name>A0A8C2TTE0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Synaptojanin-2-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Mitochondrial outer membrane protein 25</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">SYNJ2BP</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="7">Binds (via the PDZ domain) to isoform 2A of SYNJ2 (via the unique motif in the C-terminus). Interacts (via C-terminus) with RALBP1. Interacts (via PDZ domain) with ACVR2A (via C-terminus) and ACVR2B (via C-terminus). Forms a ternary complex with ACVR2A and RALBP1. Interacts with MAPK12. Interacts with DLL1; enhances DLL1 protein stability, and promotes notch signaling in endothelial cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TTE0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005025621.1">
        <property type="protein sequence ID" value="ENSCJPP00005018391.1"/>
        <property type="gene ID" value="ENSCJPG00005014979.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107314883"/>
    <dbReference type="KEGG" id="cjo:107314883"/>
    <dbReference type="GeneTree" id="ENSGT00830000128402"/>
    <dbReference type="OrthoDB" id="123971at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030054">
        <property type="term" value="C:cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045197">
        <property type="term" value="P:establishment or maintenance of epithelial cell apical/basal polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010596">
        <property type="term" value="P:negative regulation of endothelial cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001937">
        <property type="term" value="P:negative regulation of endothelial cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070373">
        <property type="term" value="P:negative regulation of ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903671">
        <property type="term" value="P:negative regulation of sprouting angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043113">
        <property type="term" value="P:receptor clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097120">
        <property type="term" value="P:receptor localization to synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030100">
        <property type="term" value="P:regulation of endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008593">
        <property type="term" value="P:regulation of Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd06709">
        <property type="entry name" value="PDZ_SYNJ2BP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000161">
        <property type="entry name" value="Synaptojanin-2-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050614">
        <property type="entry name" value="Synaptic_Scaffolding_LAP-MAGUK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119">
        <property type="entry name" value="DISCS LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119:SF51">
        <property type="entry name" value="DISKS LARGE 1 TUMOR SUPPRESSOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="11">
        <location>
            <begin position="14"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00063547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00070337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00075222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005018391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="144" mass="15325" checksum="F623C67CC639126E" modified="2022-01-19" version="1">MNGSVAGGGVSEEVIRLTRGPSGLGFNIVGGTDQQVDSNDSSIYVSRIKKDGPAYLDGRLQEGDKILAINGRDLKNLRHMDAVELFKNAGYDVILKIQHRPQNGPAGHRGGGDSGGLPLAAILIPGLALTAAAVWILLRYRHRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TTP1</accession>
    <name>A0A8C2TTP1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Caspase-8</fullName>
            <ecNumber evidence="14">3.4.22.61</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">CASP8</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>Strict requirement for Asp at position P1 and has a preferred cleavage sequence of (Leu/Asp/Val)-Glu-Thr-Asp-|-(Gly/Ser/Ala).</text>
            <dbReference type="EC" id="3.4.22.61"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the peptidase C14A family.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.61" evidence="14"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2TTP1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005026034.1">
        <property type="protein sequence ID" value="ENSCJPP00005018769.1"/>
        <property type="gene ID" value="ENSCJPG00005015246.1"/>
    </dbReference>
    <dbReference type="KEGG" id="cjo:107316523"/>
    <dbReference type="GeneTree" id="ENSGT00940000160319"/>
    <dbReference type="OrthoDB" id="6114029at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031265">
        <property type="term" value="C:CD95 death-inducing signaling complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097342">
        <property type="term" value="C:ripoptosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035877">
        <property type="term" value="F:death effector domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097110">
        <property type="term" value="F:scaffold protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071260">
        <property type="term" value="P:cellular response to mechanical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097194">
        <property type="term" value="P:execution phase of apoptosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043124">
        <property type="term" value="P:negative regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060546">
        <property type="term" value="P:negative regulation of necroptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043123">
        <property type="term" value="P:positive regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900119">
        <property type="term" value="P:positive regulation of execution phase of apoptosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032731">
        <property type="term" value="P:positive regulation of interleukin-1 beta production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045651">
        <property type="term" value="P:positive regulation of macrophage differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045862">
        <property type="term" value="P:positive regulation of proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140639">
        <property type="term" value="P:positive regulation of pyroptotic inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070269">
        <property type="term" value="P:pyroptotic inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034612">
        <property type="term" value="P:response to tumor necrosis factor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036462">
        <property type="term" value="P:TRAIL-activated apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00032">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08333">
        <property type="entry name" value="DED_Caspase_8_r1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08813">
        <property type="entry name" value="DED_Caspase_8_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.533.10:FF:000016">
        <property type="entry name" value="CASP8 and FADD-like apoptosis regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.533.10:FF:000038">
        <property type="entry name" value="Caspase 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1460:FF:000008">
        <property type="entry name" value="caspase-8 isoform X1"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033170">
        <property type="entry name" value="Caspase-8_DED1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033139">
        <property type="entry name" value="Caspase_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016129">
        <property type="entry name" value="Caspase_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001875">
        <property type="entry name" value="DED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002138">
        <property type="entry name" value="Pept_C14_p10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001309">
        <property type="entry name" value="Pept_C14_p20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015917">
        <property type="entry name" value="Pept_C14A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48169:SF7">
        <property type="entry name" value="CASPASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48169">
        <property type="entry name" value="DED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01335">
        <property type="entry name" value="DED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00376">
        <property type="entry name" value="IL1BCENZYME"/>
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        <property type="entry name" value="CASc"/>
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    </dbReference>
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        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01122">
        <property type="entry name" value="CASPASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01121">
        <property type="entry name" value="CASPASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50207">
        <property type="entry name" value="CASPASE_P10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50208">
        <property type="entry name" value="CASPASE_P20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50168">
        <property type="entry name" value="DED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="11" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="DED" evidence="17">
        <location>
            <begin position="2"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="DED" evidence="17">
        <location>
            <begin position="100"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Caspase family p20" evidence="19">
        <location>
            <begin position="235"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Caspase family p10" evidence="18">
        <location>
            <begin position="396"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00051626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00066479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00068172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005018769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="482" mass="54885" checksum="7DE8A679955B1A32" modified="2022-01-19" version="1">MEFSQLLYVISEALDRNDLASLKFLSLEHVTVRKQEDIEEPKAFFQALQEKGMIEAGDLFFLKELLYRINRIDLLAFHLGSSREEMERELQVPGRARVSPFRYLLFQLSENITQDEMKCFKFLLWKELPKCKLSPETTMLDVFIEMEKKGILREDDLTVLKSICEKVDKSLLKKIEEYEFNTFGEGEMPVTEGRRSSTGAPRDSAIWLASSVAPDSLGNCDQSSQVEVYKMTSRPRGVCLILNNHNFAKAREAVPELRKMKNRNGTDIDAEALKKVFSNLHFTVVEYRDCTAEEIRKIVSKYRCMDHNNKDCFVCCILSHGKKGIIYGVDGQEVPIQELTTSFTGQNCQSLAGKPKVFFVQACQGDAYQKGVTVETDSGEQDYSLEADARFQLDCIPSEADFLLGMATLQDYVSYRSTSQGTWYIQSLCQHLENSCPRGEDILTILTAVNQEVSSKIDKQNAGKQMPQPSFTLRKKLIFPVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TVR2</accession>
    <name>A0A8C2TVR2_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TAP binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">TAPBP</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TVR2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005026887.1">
        <property type="protein sequence ID" value="ENSCJPP00005019412.1"/>
        <property type="gene ID" value="ENSCJPG00005015724.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159200"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019885">
        <property type="term" value="P:antigen processing and presentation of endogenous peptide antigen via MHC class I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003006">
        <property type="entry name" value="Ig/MHC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003597">
        <property type="entry name" value="Ig_C1-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050380">
        <property type="entry name" value="Immune_Resp_Modulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008056">
        <property type="entry name" value="Tapasin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23411">
        <property type="entry name" value="TAPASIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07654">
        <property type="entry name" value="C1-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01669">
        <property type="entry name" value="TAPASIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00407">
        <property type="entry name" value="IGc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00290">
        <property type="entry name" value="IG_MHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="209"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="328"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="366"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="472"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="373"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="509"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="524"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005019412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="533" mass="57259" checksum="C45CE153B410B3F0" modified="2022-01-19" version="1">MSPHLPMSPHCPHVPPLSPCPPTSLCPTIVPNVPSPPHVPHCPYVPPVSLCPPNVPISPQLPMSHHCPHIPVVSPCPPGIPVSPPVRMSPQCPYVPPLSLCPPGISMSPHVPMSPHLPMSPQCPHVLSPPYITQCPHVPPVFSSPCPLTFPYPPMSSCPLTSLCPLSVPMSPHLPMSPQCPYVPLVSPYPLTSPCPTIVPNVPSPPRVPTVSLAVLTHTPTLHGHAGSPIHLHCAFAAPPSPFVLEWRHQSRGAGQVLLAYDSTSARAPRATPGAELLLGTRDGDGVTAVTLRLARPSPGDEGTYICSVFLPHGHAQTVLQLSVFAPPKVILSPKNLVVTPGMSAELRCHVSGFYPLDVTVTWQRRAEKSRPSRSTGGSVMDSWTSSHRRAADGTYSRTAAARLVPAHPQHHGDVYSCVVTHGALDKPIRVSVRLLLAGTEGPHLEDITGLFLVAFILCGLIRWLYPKAARPEEETKVTSPPRNPKYPQKPQIPPQNTSKHPKTHHSHPTLQPSVSCRNHSDLHSSSQHLSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TWD0</accession>
    <name>A0A8C2TWD0_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Interleukin 17C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">IL17C</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IL-17 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TWD0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005025643.1">
        <property type="protein sequence ID" value="ENSCJPP00005018413.1"/>
        <property type="gene ID" value="ENSCJPG00005014995.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161887"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020440">
        <property type="entry name" value="IL-17_chr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010345">
        <property type="entry name" value="IL-17_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06083">
        <property type="entry name" value="IL17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01932">
        <property type="entry name" value="INTRLEUKIN17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0202">Cytokine</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005018413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="165" mass="19087" checksum="1F7CFD28DF796595" modified="2022-01-19" version="1">LYTHTYTHIYTHIAAELRDGEAPMHLLGRSLRWEQHVPVQLVPQIEAAQRRRRRREHSCPALQLRAGLHSEPHERSISPWRYRIDEDEDRYPRKLAFAECLCTGCVDVKTGRETTALNSVPIHQTMMVLRRKPCPRPSSPGLITFEVDYIRVPVGCTCVLPRTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TWR9</accession>
    <name>A0A8C2TWR9_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tetratricopeptide repeat protein 38</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TTC38 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TWR9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005027682.1">
        <property type="protein sequence ID" value="ENSCJPP00005020043.1"/>
        <property type="gene ID" value="ENSCJPG00005016190.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000002669"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033891">
        <property type="entry name" value="TTC38"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16263">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16263:SF4">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005020043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="216" mass="24300" checksum="718393CBC3F54D19" modified="2022-01-19" version="1">GTAMAPLRDCKAWQDAGLALSTTSNEACKLFDATVRQYATWRNDENLGGIEGCLSKLKAADPNFVMGHVIANGLQLIGIGSSLRLNRDLDNALKTLMTLTKSQPLTEREKLHVLALDMFARGQRPKACEIWEQILQNHPTDLLALKFSQDTYFSIGYQVQMRDSVARVFPFWTPDVPLSSYVKGYYAFGLMESNFFDRAEELAREVICLFMMVKGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TY40</accession>
    <name>A0A8C2TY40_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TY40"/>
    <dbReference type="Ensembl" id="ENSCJPT00005028375.1">
        <property type="protein sequence ID" value="ENSCJPP00005020595.1"/>
        <property type="gene ID" value="ENSCJPG00005016542.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00910000147025"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005020595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="108" mass="12858" checksum="55DE70088E347521" modified="2022-01-19" version="1">KTGCHKGCTYLFVLFFLLPYCMQYCKLITLVCYVTKKKPKNKTKQKKNVLQFFSLPKTKWCFIFRLERISYAKHIKEKARLSQYFFVNGNAEYFVIGLFYSCNESCLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TYP3</accession>
    <name>A0A8C2TYP3_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Bridging integrator 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BIN3</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TYP3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005025840.1">
        <property type="protein sequence ID" value="ENSCJPP00005018600.1"/>
        <property type="gene ID" value="ENSCJPG00005015128.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182882"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014839">
        <property type="term" value="P:myoblast migration involved in skeletal muscle regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010591">
        <property type="term" value="P:regulation of lamellipodium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048741">
        <property type="term" value="P:skeletal muscle fiber development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009826">
        <property type="term" value="P:unidimensional cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046982">
        <property type="entry name" value="BIN3/RVS161-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174:SF3">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAR" evidence="4">
        <location>
            <begin position="1"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005018600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="308" mass="34615" checksum="48970F7770D80FCD" modified="2022-01-19" version="1">DPIPGGFCSHWDPITGGYSHWDPITGGYSHWDPITGVQPLRLHTAIGTLLQGGVQPLGSHPVGGTDIGTPYRHWDPITGGYSHWDPIPGWYSHWDPIPGGYRHWDPITGGLQPLGPHTAIGTPLRRYRHWDPITGGVTAIGTPLWGGTTFSFPQVNQIQKTVMEPLKKFSSVFPSLTMAVKRREQTLQDYRRLQGRVDKYEDKERSGAVLAKLHQAREELRPVREDFEAKNQQLLQEMPQFYSSRVEYFKPSYEALIRAQVGFYSELCSILSHLSAHIGRAALSDEQRERDNEATVTELRGLSIVGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TYW1</accession>
    <name>A0A8C2TYW1_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Steroidogenic acute regulatory protein, mitochondrial</fullName>
            <shortName evidence="12">StAR</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 12">START domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">STAR</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Steroid metabolism; cholesterol metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">May interact with TSPO.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015738575.1">
        <property type="nucleotide sequence ID" value="XM_015883089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TYW1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005025948.1">
        <property type="protein sequence ID" value="ENSCJPP00005018684.1"/>
        <property type="gene ID" value="ENSCJPG00005015198.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107323737"/>
    <dbReference type="KEGG" id="cjo:107323737"/>
    <dbReference type="CTD" id="6770"/>
    <dbReference type="GeneTree" id="ENSGT00940000155477"/>
    <dbReference type="OrthoDB" id="74575at2759"/>
    <dbReference type="UniPathway" id="UPA00296"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015485">
        <property type="term" value="F:cholesterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120020">
        <property type="term" value="F:cholesterol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008211">
        <property type="term" value="P:glucocorticoid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032367">
        <property type="term" value="P:intracellular cholesterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070859">
        <property type="term" value="P:positive regulation of bile acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08905">
        <property type="entry name" value="START_STARD1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.530.20:FF:000015">
        <property type="entry name" value="Steroidogenic acute regulatory protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029866">
        <property type="entry name" value="StAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000799">
        <property type="entry name" value="StAR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46489">
        <property type="entry name" value="STEROIDOGENIC ACUTE REGULATORY PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46489:SF1">
        <property type="entry name" value="STEROIDOGENIC ACUTE REGULATORY PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00978">
        <property type="entry name" value="STARPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00234">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 12" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="8 12" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12" id="KW-0755">Steroidogenesis</keyword>
    <keyword evidence="6 12" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="START" evidence="13">
        <location>
            <begin position="92"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005018684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="281" mass="31035" checksum="106CA0BF34425A0C" modified="2022-01-19" version="1">MLPATFKLCAAISYQHLRNVTGLRRQAAVAISQELSKLSCRSAGPSTWISQVRRRSSLLSSRLEEKPFSEMEMSYIKQGEEALQKSLSILGDQEGWKTETVADNGDKVLSKVLPDVGKVFRLEVVVDQPLDAVYNELVDNMEQMGDWNPSVKEVKILQKIGKDTLITHETAAAVPGNIIGPRDFVSVRCSRRRGSTCVLAGMSTTHGAMPEQQGFIRAENGPTCMVLRPLAGSPSQTKLTWLLSIDLKGWLPKTIINQVLSQTQVDFAKHLRQRMVQAAGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TYY3</accession>
    <name>A0A8C2TYY3_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cystatin B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">CSTB</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cystatin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2TYY3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005028672.1">
        <property type="protein sequence ID" value="ENSCJPP00005020816.1"/>
        <property type="gene ID" value="ENSCJPG00005016706.1"/>
    </dbReference>
    <dbReference type="KEGG" id="cjo:107319025"/>
    <dbReference type="GeneTree" id="ENSGT00940000154826"/>
    <dbReference type="OrthoDB" id="2429551at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004869">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002020">
        <property type="term" value="F:protease binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990000">
        <property type="term" value="P:amyloid fibril formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045861">
        <property type="term" value="P:negative regulation of proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00042">
        <property type="entry name" value="CY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.10:FF:000001">
        <property type="entry name" value="Cystatin-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000010">
        <property type="entry name" value="Cystatin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046350">
        <property type="entry name" value="Cystatin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018073">
        <property type="entry name" value="Prot_inh_cystat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001713">
        <property type="entry name" value="Prot_inh_stefin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11414">
        <property type="entry name" value="CYSTATIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11414:SF22">
        <property type="entry name" value="CYSTATIN-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00031">
        <property type="entry name" value="Cystatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00295">
        <property type="entry name" value="STEFINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00043">
        <property type="entry name" value="CY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54403">
        <property type="entry name" value="Cystatin/monellin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00287">
        <property type="entry name" value="CYSTATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0789">Thiol protease inhibitor</keyword>
    <feature type="domain" description="Cystatin" evidence="7">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005020816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="98" mass="11103" checksum="129948CBA99B7E87" modified="2022-01-19" version="1">MLCGGASKTQPATSETQQIADEVKPQLEEKEGKTFDVFTAVEFKTQLVAGTNYFIKVHVGNDEFMHLRVFRSLPHENKPLSLHGYQSSKTKHDELAYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TZC6</accession>
    <name>A0A8C2TZC6_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">UDP-glucose ceramide glucosyltransferase-like 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">UGGT1</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + UDP-alpha-D-glucose = N(4)-(alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61304"/>
            <dbReference type="Rhea" id="RHEA-COMP:14356"/>
            <dbReference type="Rhea" id="RHEA-COMP:14357"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:59080"/>
            <dbReference type="ChEBI" id="CHEBI:139493"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 8 family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSCJPT00005026622.1">
        <property type="protein sequence ID" value="ENSCJPP00005019192.1"/>
        <property type="gene ID" value="ENSCJPG00005014607.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000004600"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003980">
        <property type="term" value="F:UDP-glucose:glycoprotein glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06432">
        <property type="entry name" value="GT8_HUGT1_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000004">
        <property type="entry name" value="UDP-glucose glycoprotein glucosyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040497">
        <property type="entry name" value="Glyco_transf_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009448">
        <property type="entry name" value="UDP-g_GGtrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040693">
        <property type="entry name" value="UGGT_TRXL_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040694">
        <property type="entry name" value="UGGT_TRXL_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040692">
        <property type="entry name" value="UGGT_TRXL_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040525">
        <property type="entry name" value="UGGT_TRXL_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11226">
        <property type="entry name" value="UDP-GLUCOSE GLYCOPROTEIN:GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11226:SF3">
        <property type="entry name" value="UDP-GLUCOSE:GLYCOPROTEIN GLUCOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18404">
        <property type="entry name" value="Glyco_transf_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18400">
        <property type="entry name" value="Thioredoxin_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18401">
        <property type="entry name" value="Thioredoxin_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18402">
        <property type="entry name" value="Thioredoxin_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18403">
        <property type="entry name" value="Thioredoxin_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06427">
        <property type="entry name" value="UDP-g_GGTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="13">
        <location>
            <begin position="55"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="14">
        <location>
            <begin position="310"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="15">
        <location>
            <begin position="449"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="domain" description="UDP-glucose:glycoprotein glucosyltransferase thioredoxin-like" evidence="16">
        <location>
            <begin position="721"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="domain" description="Glucosyltransferase 24 catalytic" evidence="17">
        <location>
            <begin position="1255"/>
            <end position="1522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00081614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF18400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF18401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF18402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF18403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF18404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005019192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1577" mass="179099" checksum="EC53B1BE777209F5" modified="2022-01-19" version="1">MSPSEKERGTAGARCAGGAATVTGAPGVLGVWVSCSFVKGDSKAVTTSLTTKWSSTPLLLETSEFLSEESQEKFWNFVEASQHIRTAEQEGDDYSAYHEMLKVASQSLSPLQQNLLKFSLSLRSYSATVQAFQQIAADEPPPDGCTLFFAVHGEKTCEYDSLGTLLRTASERPKPFLFKGDHTYPASNPERPVVILYAEIGTEDFYRFHKLLVTKAEAGEITYVFRHYIANPSEEKVYLSGYGVELAIKSTEYKAKDDTQVKGTDVNATVIDEDDPIDEVQGFLFGKLRQLYPDLSEELKELRKHLVESTNEMAPLKVWQLQDLSFQTAARILAAPPVDALMVMKDLSQNFPTKARAITKTVVSLDLRTEIEENQKYFKGTLGLQPGDSALFINGLHVDLDTQDIFSLFDVLRNEARVMEGLHSLGIEGLSLHNVLKLNIQPSDSDYAVDIRSPAISWINNLEVDSRYNSWPASVQELLRPTFPGVIRQIRKNFHNLVLIVDPTHETTAELLNVAEMFFSNHIPLRIGLVFVVNDCDDVDGLQDPGVALLRVYNYVAQEMDNNYAFQTVMSIYNKVKTGDQLKVEHVVSVLEKQYPYVEVKSVLGIDSAYDQNRKAAKSYYEQTGVGPLPVVLFNGMPFQKDQLDPDDLETVTMHKILETTSIFQRAVYLGELSNDQDVVEYIMNQPNVVPRINSRILMSDREYLDLTAMNNFYVDDFARFSTLDSKDKTAAVANSMTYLTKKGMSSKEIYDDSFVRPVTFWIVGDFDKPSGRQLLYDAIKHQKSSNNVRISMINNPSEEPNSSNTIVAKAIWAALQTQTSNNAKNFITKMAKEEIAKALEAGADILEFAVGGMDTNIFKEAFESPKVDFILSHAVYCRDVLKLKKGQRAVISNGRIIGPLEDGEMFNQDDFHLLENIILKTSGQKIKSQIQQLGFEEDLASDLVMKVDALLSAQPKGEARIEYQFFEERYSAVKLRPKEGETYFDVVAIVDPVTRDAQRLAPLLLVLNQLINMNLRVFMNCQSKLSDMPLKSFYRYVLEPEISFTADNSFASGPIAKFLDMPQSPLFTLNLNTPESWMVESVRTPYDLDNIYLEEVDNIVAAEYELEYLLLEGHCYDITTGQPPRGLQFTLGTSSNPVIVDTIVMANLGYFQLKANPGAWTLRLRKGRSEDIYRIYSHDGTDSPPEADEIIVVLNNFKSKIIKVKVQKKLDMMNEDLLSDGTSENESGFWESLKWGFTGGQKNEDVKQDKDDVLNIFSVASGHLYERFLRIMMLSVLKHTKTPLKFWFLKNYLSPTFKEFIPYMAKKYNFQYELVQYKWPRWLHQQTEKQRIIWGYKILFLDVLFPLAVDKILFVDADQIVRTDLKELRDFNLDGAPYGYTPFCDSRREMDGYRFWKSGYWASHLAGRKYHISALYVVDLKKFRKIAAGDRLRGQYQGLSQDPNSLSNLDQDLPNNMIHQVPIKSLPQEWLWCETWCDDSSKKRAKTIDLCNNPMTKEPKLQAAMRIVPEWQDYDQEIKQLHNLFQKEKETGSPEVFVPRGPIVAFTELGKLYPTTPQTGRARCDAPQLHQLVACM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2TZY2</accession>
    <name>A0A8C2TZY2_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Leucine rich repeat and sterile alpha motif containing 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LRSAM1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2TZY2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005028079.1">
        <property type="protein sequence ID" value="ENSCJPP00005020353.1"/>
        <property type="gene ID" value="ENSCJPG00005016287.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00930000151044"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045806">
        <property type="term" value="P:negative regulation of endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000786">
        <property type="term" value="P:positive regulation of autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904417">
        <property type="term" value="P:positive regulation of xenophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051865">
        <property type="term" value="P:protein autoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046755">
        <property type="term" value="P:viral budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd16515">
        <property type="entry name" value="RING-HC_LRSAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09523">
        <property type="entry name" value="SAM_TAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1170.10:FF:000002">
        <property type="entry name" value="Baculoviral IAP repeat containing 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF47">
        <property type="entry name" value="LEUCINE RICH REPEAT AND STERILE ALPHA MOTIF CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SAM" evidence="10">
        <location>
            <begin position="518"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="626"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="594"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="260"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="414"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005020353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="674" mass="77564" checksum="7D434332C940EBBB" modified="2022-01-19" version="1">MPLFFRKKKPSEDAQKRLEYQMFPVVPLLSLVTSFCFYLHDNQLASLPADIGQLTSLQVLNLERNLLKCLPQSIGDLAQLQILNVKGNKLRELPATVSGLRSLRTLNISENLLQELPRVLAHVRTLETLTLDASSMTYPSADICSAGTESIQQFLCKECGIAYYPPTQYVLPALERDGGETTVDGVDRTVSRASTADSWHSSFSSQEKKMQEKLEFERRLNMGQREHALLVQQVSNQKDEILQTVREDQMRLEEGLTKHQRHLEEERLKLLQQLKQAEQGIASRIQKLIEDNQRQKQRSDILKSLENERIRMEQLMAITQEETENLRRREVASAMQQMLAESYKNKLIQMNNESRRQDLVSQACSSLAEMDEKFQQILAWQQMDQNKAVSQILQQSEMQKAAFEALQVKKDLMHRQIRNQIKLIETELLQLTQLELKRQELDTETLQGMIMEQRQALGYLLQQLLKEKKQREEELQQILLEMEAKSETKQENYWLIQYQRLLNQKPLSLKLQEEGLEKQLVNLLTELSAEHYVPVFAHHRISLGVLSTMTASDLEKMGIAETGLQRAILRRAQEILAVAKTIPELLRTVDTEVPAATQPSAPEEETPSSVVPTAPPLQWDEKKSECVVCMEQEAQMIFLPCGHVCCCQTCCKRLQTCPLCRRDIAQHVRIFYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U0M3</accession>
    <name>A0A8C2U0M3_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Family with sequence similarity 98 member B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FAM98B</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM98 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015720312.1">
        <property type="nucleotide sequence ID" value="XM_015864826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U0M3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005028480.1">
        <property type="protein sequence ID" value="ENSCJPP00005020641.1"/>
        <property type="gene ID" value="ENSCJPG00005016600.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107314953"/>
    <dbReference type="KEGG" id="cjo:107314953"/>
    <dbReference type="CTD" id="283742"/>
    <dbReference type="GeneTree" id="ENSGT00440000037341"/>
    <dbReference type="OrthoDB" id="512356at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072669">
        <property type="term" value="C:tRNA-splicing ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018797">
        <property type="entry name" value="FAM98"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31353">
        <property type="entry name" value="FAM98"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31353:SF11">
        <property type="entry name" value="PROTEIN FAM98B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10239">
        <property type="entry name" value="DUF2465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01228">
        <property type="entry name" value="EGGSHELL"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="315"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="316"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="343"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005020641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="431" mass="46020" checksum="61AE4C0032DF5127" modified="2022-01-19" version="1">MKELETSLKMECDILDALEALGYTGPLLEEEALNKAAQSGLSSPEFFDLCVWLGSQIKSLGDMEESITSADGPLSEGRKYCWSGDKDIESFQLEISGFLREMACPYSSLISGDIKDRLKEKEDCLKLLLFLSTELQALKILHSKKSKSSHLEKHNEIHQEVQAICDALGLPNSSSSDIPPLLNSVEQKIKDILSKVQKNHVGKSLLTKPLNSDQVERLEKINDALRSEYECRRRMLMKRLDVTVQSFGWSDRAKVKTDDIARIYQPKRYALSPKSTVTLAHLLAAREDLSKIIRTSSGSTRENTVCAINKVLMGRVPDRGGRPTEIEPPPPEMPPWQKRQEGGGRGGWGGGGGGGRGGWGGGGGRGGGGGGFGGGGGGGFGGGGGGFRGGGRGGGGFQGGRGDYGGRGGYGGRGGYGDPYGGRGGGGYRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U0X3</accession>
    <name>A0A8C2U0X3_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Threonylcarbamoyl-AMP synthase</fullName>
            <ecNumber evidence="5">2.7.7.87</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">YRDC</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Cytoplasmic and mitochondrial threonylcarbamoyl-AMP synthase required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate. Participates in t(6)A37 formation in cytoplasmic and mitochondrial tRNAs. May regulate the activity of some transporters.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonine + hydrogencarbonate + ATP = L-threonylcarbamoyladenylate + diphosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:36407"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="EC" id="2.7.7.87"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Interacts with RSC1A1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SUA5 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.87" evidence="5"/>
    <dbReference type="RefSeq" id="XP_015739087.1">
        <property type="nucleotide sequence ID" value="XM_015883601.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U0X3"/>
    <dbReference type="Ensembl" id="ENSCJPT00005027988.1">
        <property type="protein sequence ID" value="ENSCJPP00005020296.1"/>
        <property type="gene ID" value="ENSCJPG00005016366.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107323981"/>
    <dbReference type="KEGG" id="cjo:107323981"/>
    <dbReference type="CTD" id="79693"/>
    <dbReference type="GeneTree" id="ENSGT00390000015364"/>
    <dbReference type="OrthoDB" id="3648309at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061710">
        <property type="term" value="F:L-threonylcarbamoyladenylate synthase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051051">
        <property type="term" value="P:negative regulation of transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.870.10:FF:000007">
        <property type="entry name" value="YrdC N6-threonylcarbamoyltransferase domain containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.10">
        <property type="entry name" value="DHBP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="Sua5-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050156">
        <property type="entry name" value="TC-AMP_synthase_SUA5"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00057">
        <property type="entry name" value="L-threonylcarbamoyladenylate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17490">
        <property type="entry name" value="SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17490:SF10">
        <property type="entry name" value="THREONYLCARBAMOYL-AMP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="YrdC/RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="YrdC-like" evidence="16">
        <location>
            <begin position="67"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00058524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00063146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005020296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="276" mass="29307" checksum="8A9CF523B84F4F91" modified="2022-01-19" version="1">MLRVKGTAALAGLVRAVDGLQGPVRAVDGLQGSVRAVDGLQDPVPSRSSFLLPLPDSKARPEPRGWREAVGAALSALREGGLVAVPTDTVYGVACLAQDSSAVRSIYSLKGRNGMKPLAICIGDVEHIYRYCHVNVPDELLQDLLPGPVTLVLKRSEELNKDLNPFTSLVGVRIPNHPFIRELARACPGPLALTSANISSQASTLTVSEFQDLWPQLSLVIDGGPIGDVQSPECRLGSTVVDLSVSGKFTIIRPGCALTSTVEILRQKYGLIPESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U238</accession>
    <name>A0A8C2U238_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">PPP2R3C</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2U238"/>
    <dbReference type="Ensembl" id="ENSCJPT00005030400.1">
        <property type="protein sequence ID" value="ENSCJPP00005022138.1"/>
        <property type="gene ID" value="ENSCJPG00005017703.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155583"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:B cell homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030865">
        <property type="term" value="P:cortical cytoskeleton organization"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045579">
        <property type="term" value="P:positive regulation of B cell differentiation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002759">
        <property type="term" value="P:regulation of antimicrobial humoral response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035303">
        <property type="term" value="P:regulation of dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051900">
        <property type="term" value="P:regulation of mitochondrial depolarization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048536">
        <property type="term" value="P:spleen development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043029">
        <property type="term" value="P:T cell homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd21505">
        <property type="entry name" value="PPP2R3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000091">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.220:FF:000002">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041534">
        <property type="entry name" value="EF-hand_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039865">
        <property type="entry name" value="PPP2R3C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12085">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B'' SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12085:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B'' SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17958">
        <property type="entry name" value="EF-hand_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PP2A regulatory subunit B'' EF-hand" evidence="9">
        <location>
            <begin position="240"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005022138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="511" mass="59115" checksum="09AA3801310149D6" modified="2022-01-19" version="1">MPPTRSVGRSRPRSHPDVLPVALDALTTNGIFRVSTGPGAAYQSAPFAPPCQVRVGRCGGAMDWKRSLRNRLAARCAPKKSEQELKDEEMELFTKYYVEWKGGRAKVNTSYTNIPRFYYRLPAEDEVLLQKLREESRAVFLQRKSRELLDNEELQNLWFLLDKHQTSPMIGEEAMINYENFLKVGEKAGPKCKQFFTAKIFAKLLNNDPYGRISIMQFFNYVMRKVWLHQTRIGLSLYDVAGQGYLRESDLENYILELIPTLPQLDGLEKSFYSFYVCTAVRKFFFFLDPLRTGKIKIQDILACSFLDDLLELRDEELSKESQETNWFSAPSALRVYGQYLNLDKDHNGMLSKEELSRYGTGTLTNIFLDRVFQECLTYDGEMDYKTYLDFVLALENRKEPAALQYIFKLLDIENKGYLNVFSLNYFFRAIQEQMKIHGQEPVSFQDVKDEIFDMVKPKDPYKISLQDLINSSQGDTVTSILIDLNGFWTYENREVLVASDNDSIADADDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U343</accession>
    <name>A0A8C2U343_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cilia and flagella associated protein 70</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">CFAP70</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U343"/>
    <dbReference type="Ensembl" id="ENSCJPT00005029084.1">
        <property type="protein sequence ID" value="ENSCJPP00005021152.1"/>
        <property type="gene ID" value="ENSCJPG00005016935.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000013319"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070062">
        <property type="term" value="C:extracellular exosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052628">
        <property type="entry name" value="CFAP70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44314">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44314:SF1">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="C2" evidence="5">
        <location>
            <begin position="143"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="803"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="39"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="541"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="896"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="918"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="930"/>
            <end position="944"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005021152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1113" mass="124053" checksum="B8AE8042B7CB1D25" modified="2022-01-19" version="1">MAAASAGNGMQVSGGDGDTLTQTPIHTAAFHWLPTSNMAPTSNMAPTSNMAPTSNMAPGLTPGSPALRSREICPSREINRVAVVAGSQARHRPPPEAVEAAGSRPAAAQFGSRCSRRFFARSAPPGLLPAPRALRAMEVPKESSPHDTSAHSESQPLQSNVVQITVVKGQDLKSLKSDTSMTMVHVEFNGVILGDSSKTEVTPNGVANYNFTASFEYSPDGPNSWVDIAQKPALLTVIEVLQKDKKQKEEKTVPLGQAVLDLLPLLQGQCSFTVLAPLYAVSTSPSESLHLEAKCSLEVSVCTKKPLLSASQLSDGSFMSVTLEAAYSVPEAFVPTEPPQNYMACLQVPAVGKKEVPLLFMNGILKLHGDKEPLPRPKKWSLANVTAPGALNIPNSFILGGPYEDEDGELNKAEDREFRIQAESTKRIVWDTERRCYLDPAAVLILKKRIAECQYWPVEVCRMPLTPSSKGKTSKADKGDEDKQIFFHGVAYVNMMPLLCPGVKRIRGAFRVFAYQDSEVLEKTKRQQSVLRDLRPQISLIKEGSGTPGTNSSLSRAVPSKAQKEDKEKMSNLTKTQLSDLAEDAASLNPEGKQYVEAGTFLMMEIKLDKALVPKRQQEELTKRVKEMIPPRPLLPPRPGGAKKAVEDYHNHVANIAVAILSEYHELFGKQPPNQGATDHQTLEEQRRQLNFELNSSGKYFAFKEQLKYAVVKIVREKYLRTTAFETQEQFQAFLSELYVYLVDQMHVALNQLMYEETASPVPRIHVTNEQLWLFAREAEINKDYKLASLYHQQRITKDHRNIQYWLDYGAFCLLLEDTLKAQECFREALSLDPRHVRSLLLCGIVAVMLQHYEEAEIFFEDACCLEPSSVVAWTLSGLFYELQNNNTQAGMAFREAKKRLQPQQARERSISGKGKKTSATSVGSSSEEGVPDEEEGSASETDPEGDRQPPCTIFMKAVEFLMKFNAIQFVRMALAHELLIQQEGPSSAYYLALARTCLLKGEFSKCDDCLWNTIRIDFLNPDVWALKGHLCYLRRDFQEAKECYERTVRFVEDAEDMHFVYLRLGSIYLENKEFGKAKQIYLEACKSSASCLTWLGVGIACYRLEELVEAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U439</accession>
    <name>A0A8C2U439_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fibroblast growth factor binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FGFBP1</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fibroblast growth factor-binding protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2U439"/>
    <dbReference type="Ensembl" id="ENSCJPT00005031785.1">
        <property type="protein sequence ID" value="ENSCJPP00005023169.1"/>
        <property type="gene ID" value="ENSCJPG00005018409.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154372"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017134">
        <property type="term" value="F:fibroblast growth factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007267">
        <property type="term" value="P:cell-cell signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008543">
        <property type="term" value="P:fibroblast growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051450">
        <property type="term" value="P:myoblast proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903589">
        <property type="term" value="P:positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090050">
        <property type="term" value="P:positive regulation of cell migration involved in sprouting angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045743">
        <property type="term" value="P:positive regulation of fibroblast growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000288">
        <property type="term" value="P:positive regulation of myoblast proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010510">
        <property type="entry name" value="FGF1-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15258">
        <property type="entry name" value="FGF BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15258:SF2">
        <property type="entry name" value="FIBROBLAST GROWTH FACTOR-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06473">
        <property type="entry name" value="FGF-BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0340">Growth factor binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005023169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="216" mass="24380" checksum="A6DC3C21B7B49A0C" modified="2022-01-19" version="1">MFVFSNYYFYVLVLPNAFCACLLLILITKEKGRKPKGGKASPKGKFKSKENADCTWAVTDMSAATMRIECRNGDSTFWCEFSGDPSTCPHYAENQKTYWKQVSRSLKKQKQICQDPRSILKSKICRKGPRGSHLKLTRSSLLEAVEPAIGHPAHHATEDAQVSAASETEKQPENSLPDCVEDVDYIDQKKVAEEYCPESLLSFCNFFITMVQDKKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U480</accession>
    <name>A0A8C2U480_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cold shock domain-containing protein E1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">CSDE1</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">RNA-binding protein involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Required for efficient formation of stress granules.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of a multi subunit autoregulatory ribonucleoprotein complex (ARC), at least composed of IGF2BP1, PABPC1 and CSDE1. Interacts with STRAP. Part of a complex associated with the FOS mCRD domain and consisting of PABPC1, PAIP1, HNRPD and SYNCRIP. The interaction with PABPC1 is direct and RNA-independent. Interacts with EIF4ENIF1/4E-T.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Stress granule</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the UNR family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2U480"/>
    <dbReference type="Ensembl" id="ENSCJPT00005030524.1">
        <property type="protein sequence ID" value="ENSCJPP00005022238.1"/>
        <property type="gene ID" value="ENSCJPG00005017511.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000016950"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070937">
        <property type="term" value="C:CRD-mediated mRNA stability complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106002">
        <property type="term" value="C:mCRD-mediated mRNA stability complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106222">
        <property type="term" value="F:lncRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905172">
        <property type="term" value="F:RISC complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035613">
        <property type="term" value="F:RNA stem-loop binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070934">
        <property type="term" value="P:CRD-mediated mRNA stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0075522">
        <property type="term" value="P:IRES-dependent viral translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900152">
        <property type="term" value="P:negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070966">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, no-go decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000767">
        <property type="term" value="P:positive regulation of cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000055">
        <property type="entry name" value="Cold shock domain containing E1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000088">
        <property type="entry name" value="cold shock domain-containing protein E1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000093">
        <property type="entry name" value="cold shock domain-containing protein E1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000094">
        <property type="entry name" value="cold shock domain-containing protein E1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056400">
        <property type="entry name" value="CSDE1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024642">
        <property type="entry name" value="SUZ-C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12913:SF1">
        <property type="entry name" value="COLD SHOCK DOMAIN-CONTAINING PROTEIN E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12913">
        <property type="entry name" value="UNR PROTEIN N-RAS UPSTREAM GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
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        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23456">
        <property type="entry name" value="CSDE1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12901">
        <property type="entry name" value="SUZ-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51938">
        <property type="entry name" value="SUZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="CSD" evidence="15">
        <location>
            <begin position="60"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="CSD" evidence="15">
        <location>
            <begin position="146"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="CSD" evidence="15">
        <location>
            <begin position="220"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="CSD" evidence="15">
        <location>
            <begin position="391"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="CSD" evidence="15">
        <location>
            <begin position="559"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="CSD" evidence="15">
        <location>
            <begin position="695"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="domain" description="SUZ-C" evidence="16">
        <location>
            <begin position="770"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00044751"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00057277"/>
        </source>
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            <dbReference type="ARBA" id="ARBA00069501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51938"/>
        </source>
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    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005022238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="820" mass="90627" checksum="2388767D5630A84C" modified="2022-01-19" version="1">PLCAGGLAPPPQPPPSSPPASFPSLPALEAAGPGSMSFDPNLLHNNGHNGYPNGTSAALRETGVIEKLLTSYGFIQCSERQARLFFHCSQYNGNLQELKVGDDVEFEVSSDRRTGKPIAVKLVKIKPEALPEERINGQVVCAVPHNLESKSPAAPGQSPTGSVCYERNGEVFYLTYTPEDVEGNIQLETGDKINFVIDTNKHTGAVSARNIMLLKKKQARCQGVVCAMKEAFGFIERGDVVKEIFFHYSEFKGDLEALQPGDDVEFTIKDRNIHLKKRGGWGEVATDVRLLPQGTVIFEDISIEHFEGTVTKVIPKVPSKNQNDPLPGRIKVDFVIPKELPFGDKDTKSKVTLLESDHVRFNISTDRRDKLERATNIEVLPNTFQFTNETREMGVIAAMRDGFGFIKCVDRDARMFFHFSEIMDGNQLHISDEVEFTVVPDMLSAQRNHAIRIKKLPKGTVSFHTQSDHRFVGTIDKEATPAKATSPNKGKEKEAEDGIIVYDDCGVKLTIPYQAKDVEGSANPQIGDKVEFSVCEVKRTGLQTAVSVRMLGRNYSSKRLLGYVAALKDNFGFIETANHDKEIFFHYSEYCGDIDSLELGDTVEYSLSKGKGNKVSAEKVNKTHAGKTDRIDKQKGLILSCMFSSLGEMKGEFYPFGIVGMANKGDCLQKGETVKFQLCVLGQNGQTMAVNITPFRRATVECVKDQFGFINYEVGDSKKLFFHVKEVQDGVELQAGDEVEFSVILNQRTGKCSACNVWRVCEGAKAVAAPRPDRLVNRLKNINLDDANAPRLTVLRQPRGPDNSKGFGAERKIRQAGVID</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U4J1</accession>
    <name>A0A8C2U4J1_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ubiquitin carboxyl-terminal hydrolase 12-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC107312855</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U4J1"/>
    <dbReference type="Ensembl" id="ENSCJPT00005029216.1">
        <property type="protein sequence ID" value="ENSCJPP00005021258.1"/>
        <property type="gene ID" value="ENSCJPG00005017014.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153284"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02663">
        <property type="entry name" value="Peptidase_C19G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000131">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
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        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF860">
        <property type="entry name" value="UBIQUITIN SPECIFIC PEPTIDASE 12-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="3">
        <location>
            <begin position="42"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005021258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="378" mass="43900" checksum="16452C7957829D05" modified="2022-01-19" version="1">MCWMPVRIAQHCFVSCRKQGANASALEKEIGPEQFPVNEHYFGLVNFGNTCYCNSVLQALYFCRPFREKVLAYKVQPRKKESLLTCLSDLFNSIATQKKKVGVIPPKKFISRLRKENELFDNYMQQDAHEFLNYLLNTIADLLQEEKKQEKQNGKLQNGSIESEEGDKTDLTWVHEIFQGTLTNETRCLNCEAVSSKDEDFLDLSVDVEQNTSITHCLRGFSNTETLCSEYKYYCEQCRSKQEAQKRMRVKKLPMILALHLKRFKYMDQLHRYTKLSYRVVFPLELRLFNTSGDATNPDRMYDLVAVVVHCGSGPNRGHYITIVKSHGFWLLFDDDIVEANSIQLETDENHRYYSICGRNSVKSRRQVSSNEILLQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U4X9</accession>
    <name>A0A8C2U4X9_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">EvC ciliary complex subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">EVC2</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_015718122.1">
        <property type="nucleotide sequence ID" value="XM_015862636.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCJPT00005031987.1">
        <property type="protein sequence ID" value="ENSCJPP00005023334.1"/>
        <property type="gene ID" value="ENSCJPG00005018529.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107313925"/>
    <dbReference type="KEGG" id="cjo:107313925"/>
    <dbReference type="CTD" id="132884"/>
    <dbReference type="GeneTree" id="ENSGT00940000154127"/>
    <dbReference type="OrthoDB" id="8852462at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060170">
        <property type="term" value="C:ciliary membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098797">
        <property type="term" value="C:plasma membrane protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007224">
        <property type="term" value="P:smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022076">
        <property type="entry name" value="Limbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026501">
        <property type="entry name" value="Limbin/EVC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16795:SF14">
        <property type="entry name" value="LIMBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16795">
        <property type="entry name" value="LIMBIN/ELLIS-VAN CREVELD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12297">
        <property type="entry name" value="EVC2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="459"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="774"/>
            <end position="811"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005023334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1311" mass="150904" checksum="02F63D4E9BBF067C" modified="2022-01-19" version="1">MDAKAEARSGSGQRGALRAGPVPCGAGRLLAGLLVVLLPSVPAQLLGAVARRLTQGHGVPGPPRGHCGRTEAGVIKDDPWLQKEMKCLGMTALQLPLMVQASEVPDLILTSAASDDEWSHSIFAMIPSWTRKILFKRESSVSHQLTEDVSKLSASSGFGITFQKCAVVDVEHDPQTAYIRLLINNTNSLLSRNITDLILVDNITGLHVQKDSGNETRDGMQIYRKRFLQVGEYFAINYTALLDAKKTWNGRVLTLPAQLTFRSSSQNQTDLVSLTTLFTITEEEKTEVSYSHAIHASGFFIAFFVSLVLTCAVFFILYRTQLLRWSFYSKNQEIQHELSQSHKLEHSQFNSGDLFSEDVIMNDQIIDILTFEEPGNMLQALEDLEVASLNRADADLEAYRMQICKEVIAMMMKNIVLSHSLIPHVEKRMSSVFKKQFLTMEREFQEEYERKVVALTAECNLETRKKMEAQRQKERAANEEAEELMKKVNEMPAVEYKSLLDRLHSLEQDHLKRFLLVKQEEYFAKAYRQLAVSQRKELHNIFFTQITDATFKGELKLEIAKSLVEDYSKIQGDIEELMDFLQASKKYHLNRRFAYREYLIRKMQLRDSQASALINAAATQILNLINKTERAGHLHESHLGMLLDRAEAEINSVKQKFNHDLKQEKQKLHQKLITKRKWKMLQKKEHRKEQLSIGTPFKTSREITDYLSHWKTLLCDHATEFEELTEKLDSESSEELRDLIFNLSEKTVEELKLIQYGVIVQELLKLGVPKMFLLEVVEEHKKEIIVKHEHLEREEREKSMAAEELLQLTRQKFSQELENSLSQQKKLRSWEQSVFMKLLTLPLSLSEEELLKMRQEFHCCFSQLDSSLALTKIRARALLQAFELEWRDAQLLKVSQNLAMTSKQPHAKTKKTGSKNRNKIDILKKSLQDKIFIYQDSVKVENLTKVNYELLLEKDCQIHDLENKLGEYIASLEFQKSVKKCKMLELYSAIISVQALLLENLSMSKTLSKSECIQILEAHNPEIEELDRKLEYEMLHKESAQQQQQHLVNKQRWTLDGLRPSGEAVETNADRQVTFLLRQAMSKCMQFINLQQQSLRDEQWNGMVLEDLLENREMDAFLALYSQELRIAGYLARLTRVPMGMLHRILNLLLPSSSQSEVLSILDSIGVYSDGAAESDSNADESGSCKKRRNQECWQALEYKVREDLISKSLERILSINRRKDSLIKKKQLALLERPSFIHLESWPTRPPVEQSSPLVSFNSVTAEAIEVLDTGEKIFLFRDRSDPTLSFHNYPRKKKKNFLNSKKAARASIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U556</accession>
    <name>A0A8C2U556_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome c oxidase subunit 7B, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Cytochrome c oxidase polypeptide VIIb</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC107312769</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome c oxidase VIIb family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2U556"/>
    <dbReference type="Ensembl" id="ENSCJPT00005029284.1">
        <property type="protein sequence ID" value="ENSCJPP00005021315.1"/>
        <property type="gene ID" value="ENSCJPG00005017062.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000012178"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01403">
        <property type="entry name" value="Cyt_c_Oxidase_VIIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.51.10:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit 7B, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.51.10">
        <property type="entry name" value="Cytochrome C Oxidase, chain K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008433">
        <property type="entry name" value="Cyt_c_oxidase_suVIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023272">
        <property type="entry name" value="Cyt_c_oxidase_suVIIB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16716">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 7B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16716:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 7B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05392">
        <property type="entry name" value="COX7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81423">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit VIIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005021315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="178" mass="19371" checksum="F739F1D4C8D411F2" modified="2022-01-19" version="1">AYGATAGRLLLPASSGVCFPDSPEPAEQRNSRCVPPATQLSPLGLPRSEHGAFPSPLRGAPAELHYPECSTRRRDVSATSRAAILFFSAVQGYRALSRTMFPVARAALNLTARGVHRTAVRQSHHRKHEPNFHDKYGNLVLLGGAAVFASVWGYVLTQSGMEWGLSPVGRITPKEWRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U5M2</accession>
    <name>A0A8C2U5M2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LIM/homeobox protein Lhx1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Homeobox protein Lim-1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LHX1</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2U5M2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005030553.1">
        <property type="protein sequence ID" value="ENSCJPP00005022265.1"/>
        <property type="gene ID" value="ENSCJPG00005017780.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160834"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001658">
        <property type="term" value="P:branching involved in ureteric bud morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021702">
        <property type="term" value="P:cerebellar Purkinje cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021937">
        <property type="term" value="P:cerebellar Purkinje cell-granule cell precursor cell signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072049">
        <property type="term" value="P:comma-shaped body morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009953">
        <property type="term" value="P:dorsal/ventral pattern formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001705">
        <property type="term" value="P:ectoderm formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060059">
        <property type="term" value="P:embryonic retina morphogenesis in camera-type eye"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048703">
        <property type="term" value="P:embryonic viscerocranium morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001706">
        <property type="term" value="P:endoderm formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021871">
        <property type="term" value="P:forebrain regionalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097477">
        <property type="term" value="P:lateral motor column neuron migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048382">
        <property type="term" value="P:mesendoderm development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072283">
        <property type="term" value="P:metanephric renal vesicle morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072284">
        <property type="term" value="P:metanephric S-shaped body morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008045">
        <property type="term" value="P:motor neuron axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035849">
        <property type="term" value="P:nephric duct elongation"/>
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        <property type="term" value="P:paramesonephric duct development"/>
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        <property type="term" value="P:positive regulation of anterior head development"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:positive regulation of branching involved in ureteric bud morphogenesis"/>
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    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:2000543">
        <property type="term" value="P:positive regulation of gastrulation"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:2000768">
        <property type="term" value="P:positive regulation of nephron tubule epithelial cell differentiation"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0090009">
        <property type="term" value="P:primitive streak formation"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0048793">
        <property type="term" value="P:pronephros development"/>
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    <dbReference type="GO" id="GO:0010842">
        <property type="term" value="P:retina layer formation"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0032525">
        <property type="term" value="P:somite rostral/caudal axis specification"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:spinal cord association neuron differentiation"/>
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        <property type="term" value="P:telencephalon development"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:transcription by RNA polymerase II"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:ureter morphogenesis"/>
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        <property type="term" value="P:urogenital system development"/>
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        <property type="term" value="P:vagina development"/>
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        <property type="term" value="P:ventral spinal cord development"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09367">
        <property type="entry name" value="LIM1_Lhx1_Lhx5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09375">
        <property type="entry name" value="LIM2_Lhx1_Lhx5"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Insulin gene enhancer protein ISL-2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="LIM/homeobox protein Lhx1"/>
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        <property type="entry name" value="LIM/homeobox protein Lhx1"/>
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        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="Homeodomain-like"/>
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        <property type="entry name" value="HD"/>
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        <property type="entry name" value="Homeobox_CS"/>
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    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
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    <dbReference type="InterPro" id="IPR049618">
        <property type="entry name" value="Lhx1/5_LIM1"/>
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        <property type="entry name" value="Lhx1/5_LIM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050453">
        <property type="entry name" value="LIM_Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208">
        <property type="entry name" value="LIM/HOMEOBOX PROTEIN LHX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208:SF106">
        <property type="entry name" value="LIM_HOMEOBOX PROTEIN LHX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
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    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="HOMEOBOX_1"/>
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        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="LIM_DOMAIN_1"/>
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        <property type="entry name" value="LIM_DOMAIN_2"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="6 11 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 11 13" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 12" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="15">
        <location>
            <begin position="2"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="15">
        <location>
            <begin position="62"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="16">
        <location>
            <begin position="178"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="11">
        <location>
            <begin position="180"/>
            <end position="239"/>
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    <feature type="region of interest" description="Disordered" evidence="14">
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        <location>
            <begin position="444"/>
            <end position="467"/>
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        <location>
            <begin position="125"/>
            <end position="136"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
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            <begin position="151"/>
            <end position="167"/>
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            <begin position="392"/>
            <end position="404"/>
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    </feature>
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            <begin position="405"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005022265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="507" mass="56210" checksum="2B850AA38CBB4A37" modified="2022-01-19" version="1">MVHCAGCKRPILDRFLLNVLDRAWHVKCVQCCECKCNLTEKCFSREGKLYCKNDFFRCFGTKCAGCAQGISPSDLVRRARSKVFHLNCFTCMMCNKQLSTGEELYIIDENKFVCKEDYLNNSNTAKENSLHSATTGSDPSLSPDSQDPSQDDAKDSESANVSDKETGSNENDDQNLGAKRRGPRTTIKAKQLETLKAAFAATPKPTRHIREQLAQETGLNMRVIQVWFQNRRSKERRMKQLSALGARRHAFFRSPRRMRPLVDRLEPGELLPNGPFSFYGGGYSAVALRPVLGAGWAERQEPRPGEPQPPVSQPHTGPGLEGFPVAGVAVPGPGCAVALLSVRLVASRCAAAGRGPAAPYPPLRSSPPLRYARALVLRATARVFPYRQITRASTTAPGATTSSSRKARPPRRRRRRWSCRSGRRADRRAHRWARWSIRCPGITRPERRSASPTCWRTPPGTRPAPSPPCPAPCTPCPRKCSAPVLRSPRYPSTAVLTTAITCHTHQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U6H7</accession>
    <name>A0A8C2U6H7_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BTG anti-proliferation factor 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BTG2</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BTG family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015740829.1">
        <property type="nucleotide sequence ID" value="XM_015885343.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U6H7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005032768.1">
        <property type="protein sequence ID" value="ENSCJPP00005023982.1"/>
        <property type="gene ID" value="ENSCJPG00005018956.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107324908"/>
    <dbReference type="KEGG" id="cjo:107324908"/>
    <dbReference type="CTD" id="7832"/>
    <dbReference type="GeneTree" id="ENSGT00950000182952"/>
    <dbReference type="OrthoDB" id="19928at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009952">
        <property type="term" value="P:anterior/posterior pattern specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008306">
        <property type="term" value="P:associative learning"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021954">
        <property type="term" value="P:central nervous system neuron development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007406">
        <property type="term" value="P:negative regulation of neuroblast proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007405">
        <property type="term" value="P:neuroblast proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060213">
        <property type="term" value="P:positive regulation of nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035914">
        <property type="term" value="P:skeletal muscle cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.90:FF:000003">
        <property type="entry name" value="BTG1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.90">
        <property type="entry name" value="Anti-proliferative protein, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002087">
        <property type="entry name" value="Anti_prolifrtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033332">
        <property type="entry name" value="BTG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036054">
        <property type="entry name" value="BTG-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22978">
        <property type="entry name" value="B-CELL TRANSLOCATION GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22978:SF29">
        <property type="entry name" value="PROTEIN BTG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07742">
        <property type="entry name" value="BTG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00310">
        <property type="entry name" value="ANTIPRLFBTG1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00099">
        <property type="entry name" value="btg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160696">
        <property type="entry name" value="BTG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00960">
        <property type="entry name" value="BTG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01203">
        <property type="entry name" value="BTG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anti-proliferative protein" evidence="2">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Anti-proliferative protein" evidence="3">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005023982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="164" mass="18325" checksum="5308140A0373B50D" modified="2022-01-19" version="1">MSQRRVPPQRADMLPEIAAAVGFVSGLLRTRGCVSEQQLQVFSGALREALAEHYKHHWFPEKPFKGSGYRCIRINHKMDPIISKAASQIGLSLPQLYQLLPSELTLWVDPYEVSYRIGEDGSICVLYEATAAKPVSSYGMLTCKNQMMLGRTSPSKNYIMTVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U808</accession>
    <name>A0A8C2U808_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Adiponectin receptor 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ADIPOR2</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ADIPOR family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015720832.1">
        <property type="nucleotide sequence ID" value="XM_015865346.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015720841.1">
        <property type="nucleotide sequence ID" value="XM_015865355.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_032301194.1">
        <property type="nucleotide sequence ID" value="XM_032445303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U808"/>
    <dbReference type="Ensembl" id="ENSCJPT00005033708.1">
        <property type="protein sequence ID" value="ENSCJPP00005024744.1"/>
        <property type="gene ID" value="ENSCJPG00005019485.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107315224"/>
    <dbReference type="KEGG" id="cjo:107315224"/>
    <dbReference type="CTD" id="79602"/>
    <dbReference type="GeneTree" id="ENSGT00940000156451"/>
    <dbReference type="OrthoDB" id="5585746at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097003">
        <property type="term" value="F:adipokinetic hormone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055100">
        <property type="term" value="F:adiponectin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033211">
        <property type="term" value="P:adiponectin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042593">
        <property type="term" value="P:glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120162">
        <property type="term" value="P:positive regulation of cold-induced thermogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061042">
        <property type="term" value="P:vascular wound healing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF33">
        <property type="entry name" value="ADIPONECTIN RECEPTOR PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005024744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="386" mass="43585" checksum="9FE08876AEC740FE" modified="2022-01-19" version="1">MNELTELDNAGSPEPGLRLRKGHMSDTATTQTAFEEDNSEQRLLLVEPPLSSNQENSSEGNNHNDESPQEDEGFMGMSPLLQAHHAMERMEEFVCKVWEGRWRVIPHDVLPDWLKDNDYLLHGHRPPMPSFRACFKSIFRIHTETGNIWTHLLGCVFFLCLGIFYMFRPNMSFVAPVQEKVVVGLFFLGAILCLSFSWLFHTVYCHSEGVSRLFSKLDYSGIALLIMGSFVPWLYYSFYCNPQPCFIYLIVICVLGIAAIIVSQWDMFATPQYRGVRAGVFLGLGLSGVIPTLHFVISEGLLKAATMGQIGWLALMACLYITGAALYAARIPERFFPGKCDIWFHSHQLFHVFVVAGAFVHFHGVSNLQEFRFTVGGGCTEEEGMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U927</accession>
    <name>A0A8C2U927_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serpin family E member 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">SERPINE3</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the serpin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2U927"/>
    <dbReference type="Ensembl" id="ENSCJPT00005034313.1">
        <property type="protein sequence ID" value="ENSCJPP00005025200.1"/>
        <property type="gene ID" value="ENSCJPG00005019806.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160941"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19574">
        <property type="entry name" value="serpinE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031172">
        <property type="entry name" value="Serpin_E3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461:SF129">
        <property type="entry name" value="SERPIN E3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00093">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034070880" evidence="2">
        <location>
            <begin position="19"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Serpin" evidence="3">
        <location>
            <begin position="35"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005025200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="411" mass="45606" checksum="305C20E37386215D" modified="2022-01-19" version="1">MLPTVSFALILTWCLAKGNCISYDELKDLKTEFAINLYRHASEAENRTNLVISPASVAISLELLQFGAQGNTFTELQNALGYNIHDQSVQDMLHKVYEGTADSGQGAVVQLACSFFMHTGVQLSPHFAAHVSHWANSSLQQADFTDPNQTAALIQGHSSPGWMWLWAACRVAVVSTMYFKSTWLKKFSFMDTQILPFTTAESSTLKVPTMHHTAEVNYGQFQTTTQDAFSVVELPYLGEKLSMFIVLPSHKRTPLSQIESHLSAKTIALWSSSLKRTKMDIFLPRFSIQSLFDLKTVFSALGIRDAFDPITANFKGISEQAGLYISEAIHKAKIEVTEDGTKASGATAMVLLKRSRTPVFKADRPFTFFLRQANTGTHTKAQQKSLQFVHSPLQSLSGFSKTLFGDLPKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2U9F5</accession>
    <name>A0A8C2U9F5_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rab9 effector protein with kelch motifs-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC107315137</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2U9F5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005033362.1">
        <property type="protein sequence ID" value="ENSCJPP00005024484.1"/>
        <property type="gene ID" value="ENSCJPG00005019286.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000164710"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF19">
        <property type="entry name" value="RAB9 EFFECTOR PROTEIN WITH KELCH MOTIFS-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13415">
        <property type="entry name" value="Beta-prop_FBX42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005024484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="624" mass="68479" checksum="DDE6E5E3BC083247" modified="2022-01-19" version="1">MGHAVPSARWAARRRLGAVDARRPPTAAPPSGTFMAATHGLFSFSPASHAVRRGPAAQGAGGAACENELAFYVLWALQEPPRRLSSQSSKMGYQAWLPLPLPRQLVVFSLGDWSCYSPDTSITVDVLVAPGIGVQQLGTLGPACRSLVWEGDWRTDVFKASLKETHESNPVKLVLTVHGQLLRGVSSSTPAHSFLVPEATQSPVLPAADRPLDQDVEDPSAVKGQNSEMIARASWPVRKDFHTPLRSLVVPYALKPAPHEVEPSDNWKESPVCPKKPRKILFEPRESERELDVEDLAVEELQGSPSPRWCHAMCLSDLGTAVLVGGEGADQQPCKDALWKLEIDSNFWFPVSLQEQNTMPSCLRGHTATYDPDTKRIYIFGGIKEDEDYSGIYILDTVTWKWLLVDAKGRIPSLTYHSATIYHKELFVFGGAFPKVAPMAVGPCSNILYVFNPEHEIWYQPISEGEKPLPRLGHSATLLKNKLLIFGGRRSCLYLSDMHVLDLGFMEYTPVALCGQPSARCFHAALAVSDWKVLISGGCSAEGALQDAFVFHLDTLSWSTVIHPDLCSVPRAGHTLLDLTPAHTTDVDKENKNKHNLHTVLVFGGSDCAGTFYNITKKIQLDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UBM8</accession>
    <name>A0A8C2UBM8_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cytochrome c oxidase assembly homolog COX15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">COX15</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2</text>
            <dbReference type="Rhea" id="RHEA:63388"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:60530"/>
            <dbReference type="ChEBI" id="CHEBI:61715"/>
            <dbReference type="EC" id="1.17.99.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:63389"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10">Porphyrin-containing compound metabolism; heme A biosynthesis; heme A from heme O: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2UBM8"/>
    <dbReference type="Ensembl" id="ENSCJPT00005033795.1">
        <property type="protein sequence ID" value="ENSCJPP00005024811.1"/>
        <property type="gene ID" value="ENSCJPG00005019524.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000002223"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070069">
        <property type="term" value="C:cytochrome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120547">
        <property type="term" value="F:heme A synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016653">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01665">
        <property type="entry name" value="HemeA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003780">
        <property type="entry name" value="COX15/CtaA_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023754">
        <property type="entry name" value="HemeA_Synthase_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23289">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23289:SF2">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02628">
        <property type="entry name" value="COX15-CtaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="319"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="364"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="423"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="452"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="482"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005024811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="507" mass="55993" checksum="194222264BBB384F" modified="2022-01-19" version="1">MAAPVCLAASRRASRPLPPQAPPPPLHIRPRPLAAQLPLRPSPAPVPRGGDAVALCPGPAPPRWALAPPRPAPPLPLLHLRWRRAGPAAGSGSRATELSWRRLGVTGRARPVSATLPPLPVRLVMLRALCGGAGRFVRPCRQLGSLRYRPQRGLPLQHSPDVPPAVGRWLLACSGAVAGAVVLGGVTRLTESGLSMVDWHLVKEMKPPRTQQEWEAEFQKYQQFPEFKILNRDMTLTEFKFIWYMEYSHRMWGRVVGLAYILPAAYFWRKGWLSRPMKGRVLALCGLVCFQGLLGWYMVKSGLEEKPDSYDIPRVSQYRLAAHLGSALVLYSASLWMGLSLLLPRHQLHETRQLLQLRHFAHGATALIFLTALSGAFVAGLDAGLVYNSFPKMGERWIPDDLLAFSPTLRNIFENPTTVQFDHRILGTASVTAVTALYLFSRKISLPHRTRMAVTSLLAVAWAQVALGISTLLLYVPTPLAATHQSGSLALLSVALWLMSELRRLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UBR7</accession>
    <name>A0A8C2UBR7_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Folylpolyglutamate synthase</fullName>
            <ecNumber evidence="17">6.3.2.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Folylpoly-gamma-glutamate synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Tetrahydrofolylpolyglutamate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">FPGS</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + L-glutamate + ATP = (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10580"/>
            <dbReference type="Rhea" id="RHEA-COMP:14738"/>
            <dbReference type="Rhea" id="RHEA-COMP:14740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:141005"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>a monovalent cation</name>
            <dbReference type="ChEBI" id="CHEBI:60242"/>
        </cofactor>
        <text evidence="17">A monovalent cation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 17">Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 17">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.17" evidence="17"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2UBR7"/>
    <dbReference type="Ensembl" id="ENSCJPT00005034546.1">
        <property type="protein sequence ID" value="ENSCJPP00005025393.1"/>
        <property type="gene ID" value="ENSCJPG00005019938.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000016526"/>
    <dbReference type="UniPathway" id="UPA00850"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006536">
        <property type="term" value="P:glutamate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.20:FF:000007">
        <property type="entry name" value="Folylpolyglutamate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="entry name" value="Mur ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="entry name" value="Mur-like, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023600">
        <property type="entry name" value="Folylpolyglutamate_synth_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136:SF5">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038895">
        <property type="entry name" value="FPGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="MurD-like peptide ligases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="MurD-like peptide ligases, peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01011">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01012">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 17" id="KW-0436">Ligase</keyword>
    <keyword evidence="13 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 17" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="19">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR038895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR038895-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR038895-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005025393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="557" mass="60479" checksum="316B946156CCDF01" modified="2022-01-19" version="1">MRGFLERSGLRVEDLDRLNIIHVTGTKGKGSACAFTERILRGYGLRTGFYSSPHLVQVRERIRINGQPLSKELFSKYFWLVYRRLRGSKDEAQANMPAYFRFLTIMAFHVFLQEKVDLAVVEVGIGGAFDCTNIIRTPVVCGVSSLGIDHTSILGDTVEKIAWQKGGIFKPGVPAFTVPQPEQPLEVLRDRARECGCPLYLCPELDAFEAGMRVLELGLAGSHQRSNAALALQLSRTWLQRRGYEGSDVLQDVLPGAELSAQRSVPLAPTFCPSDAMIQGAVRAGGGGGAVLDCGSPCGAILVLGVAGPRHALCLPPPGLRDTEWPGRTQVLQHGPVTWYIDGAHTTSSIQACVRWFRQAALNEDKPQDGSEVRVLLFNATGDRDTAALLKLLLPCHFDYAVFCPNFTEVSVAPNADQQNFNVTLENALTRCVENQKTWTRLMEEKGGPWLPAPLEVGGLLQPDPLRGALLLVPPAERPLNSTSLVFPCISHALQWITQGRDPHLSLPASKVGAHPHPVATSGAVLLQEAAAIRVLVTGSLHLVGGVLKLLDPTLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UBT5</accession>
    <name>A0A8C2UBT5_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Family with sequence similarity 187 member A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">FAM187A</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAM187 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2UBT5"/>
    <dbReference type="Ensembl" id="ENSCJPT00005032873.1">
        <property type="protein sequence ID" value="ENSCJPP00005024077.1"/>
        <property type="gene ID" value="ENSCJPG00005019026.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063991"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039311">
        <property type="entry name" value="FAM187A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32178">
        <property type="entry name" value="FAM187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32178:SF7">
        <property type="entry name" value="IG-LIKE V-TYPE DOMAIN-CONTAINING PROTEIN FAM187A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="261"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005024077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="405" mass="46711" checksum="43816237D07AE4A1" modified="2022-01-19" version="1">FTLNHTTRAGGGGNAEKDDVFRRMVCPAFLMFDNAAYLADMTFELPCNCKPEEVSNVVWYFQKSMGGHETTVLTDFSGNMVLDSGHIHVGSDVLKRFTIRMFSLIIFRAQESDSGHYICGTKKGDFFYGYDVDVQPTKRITVAFLDEGQHVQDDYTGKAFSVFTTFWDWTKCDRCGVRGEQRRIGLCYMQSTRLHPRYRTVLHNVTSCGSRAVPPRFQRSGRRWKPEVAIRSCTTPCEQEDNPQEGVQAISNIIHKLGQKPWLPNVPTQYYKHPLGRDLVIACPRARPEHAVAWDWDSVRLYRSRYLVGVNRTMRVFIDHGNHLHIRRVRFSDRGTYFCWREGKLVAGLRLTVSYESKSRRKLTDPETIYILKAISVSYILIGAIFFSIHLSRCCWRMLRSSART</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UEA6</accession>
    <name>A0A8C2UEA6_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Sugar phosphate exchanger 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Solute carrier family 37 member 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">SLC37A3</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015722434.1">
        <property type="nucleotide sequence ID" value="XM_015866948.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015722440.1">
        <property type="nucleotide sequence ID" value="XM_015866954.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_015722449.1">
        <property type="nucleotide sequence ID" value="XM_015866963.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UEA6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005035226.1">
        <property type="protein sequence ID" value="ENSCJPP00005025953.1"/>
        <property type="gene ID" value="ENSCJPG00005020286.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107315976"/>
    <dbReference type="KEGG" id="cjo:107315976"/>
    <dbReference type="CTD" id="84255"/>
    <dbReference type="GeneTree" id="ENSGT00940000163139"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006855">
        <property type="term" value="P:xenobiotic transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17342">
        <property type="entry name" value="MFS_SLC37A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000028">
        <property type="entry name" value="Sugar phosphate exchanger 3 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000132">
        <property type="entry name" value="sugar phosphate exchanger 3 isoform X1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000849">
        <property type="entry name" value="Sugar_P_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43184">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY TRANSPORTER 16, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43184:SF12">
        <property type="entry name" value="SUGAR PHOSPHATE EXCHANGER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002808">
        <property type="entry name" value="Hexose_phosphate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0458">Lysosome</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="340"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="364"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="393"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="429"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="463"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="15">
        <location>
            <begin position="27"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005025953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="501" mass="54908" checksum="65AC702B69C6FE8C" modified="2022-01-19" version="1">MAVPGSSRRQPANRGLVSHCTHHHVVVFLLTFFSYSLLHASRKTFSNVKVSISNQWTPSCLNSTTFELRPNELWNSNHLFPSAEEATLFLGTLDTIFLFSYAVGLFVSGIVGDRLNLRWVLSFGMCSSALVVFFFGTLTEWLHFYNKWFYCCLWVVNGLLQSTGWPCVVAVMGNWFGKAGRGFVFGLWSACASVGNILGAFLASCVLKYGYEYAFLVTASVQFAGGVIVFCGLLTSPKEVGLPELGADEEGSVEEDANRPLMGDDDADDDEGNYSIQASDTDSQPQAIGFFQACCLPGVVLYSLAYACLKLVNYSFFFWLPFYLSNNFGWKEAEADQLSIWYDVGGIIGGTIQGLISDVLQKRAPVLAISLLFAVGSLFGYSRSPNSKPINAVIMAITGFFIGGPSNMISSAISADLGRQDLVRGSSEALATVTGIVDGTGSIGAAVGQYLVSLIQENLGWMWVFYFFILMTSSTILFISPLIVREIRLLLHERHLRMLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UF18</accession>
    <name>A0A8C2UF18_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">ATP-dependent clpX-like chaperone, mitochondrial</fullName>
            <ecNumber evidence="2">3.6.4.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">CLPX</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">ATP-dependent chaperone that functions as an unfoldase. As part of the ClpXP protease complex, it recognizes specific protein substrates, unfolds them using energy derived from ATP hydrolysis, and then translocates them to the proteolytic subunit (CLPP) of the ClpXP complex for degradation. Thanks to its chaperone activity, it also functions in the incorporation of the pyridoxal phosphate cofactor into 5-aminolevulinate synthase, thereby activating 5-aminolevulinate (ALA) synthesis, the first step in heme biosynthesis. This chaperone is also involved in the control of mtDNA nucleoid distribution, by regulating mitochondrial transcription factor A (TFAM) activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.10"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="16">Homohexamer that forms a ring structure; this hexamerization requires ATP binding. Component of the ClpXP complex formed by the assembly of two CLPP heptameric rings with two CLPX hexameric rings, giving rise to a symmetrical structure with two central CLPP rings flanked by a CLPX ring at either end of the complex. Interacts with TFAM.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
            <location evidence="1">Mitochondrion nucleoid</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.4.10" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A8C2UF18"/>
    <dbReference type="Ensembl" id="ENSCJPT00005036157.1">
        <property type="protein sequence ID" value="ENSCJPP00005026699.1"/>
        <property type="gene ID" value="ENSCJPG00005020729.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000017625"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009841">
        <property type="term" value="C:mitochondrial endopeptidase Clp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016504">
        <property type="term" value="F:peptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd19497">
        <property type="entry name" value="RecA-like_ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000002">
        <property type="entry name" value="ATP-dependent Clp protease ATP-binding subunit ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000378">
        <property type="entry name" value="ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003247">
        <property type="entry name" value="ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050052">
        <property type="entry name" value="ATP-dep_Clp_protease_ClpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004487">
        <property type="entry name" value="Clp_protease_ATP-bd_su_ClpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059188">
        <property type="entry name" value="Znf_CLPX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059067">
        <property type="entry name" value="Znf_ribbon_CLPX-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00382">
        <property type="entry name" value="clpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003745">
        <property type="entry name" value="PRK05342.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48102:SF7">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPX-LIKE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48102">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPX-LIKE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26040">
        <property type="entry name" value="Zn_ribbon_CLPX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51902">
        <property type="entry name" value="CLPX_ZB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1135">Mitochondrion nucleoid</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ClpX-type ZB" evidence="20">
        <location>
            <begin position="92"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="65"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="597"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="69"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="597"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="610"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00050527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00058714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00065499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00073042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00077425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005026699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="632" mass="69305" checksum="3566DB937A477B3F" modified="2022-01-19" version="1">GRAMSACHSCAAAARLLGSTLPSARRGITCGRTRIPVLGKLGTFETCSLRRIPLRNFSETPAYFASKDGTGKDGSEGSKKSVSEGGGKKSSSGSSGKGGNQLRCPKCGDLCTHVETFVSSTRFVKCEKCHHFFVVLSEADTKKSIIKEPESAAEAVKLAFQQKPPPPPKKIYNYLDKYVVGQCFAKKVLSVAVYNHYKRIYNNIPANLRQQAEVEKQTSLTPRELEIRRREDEYRFTKLLQIAGISPHGNALGASMQQQMNQQIPQEKRGGEVLDSPNDDIKLEKSNILLLGPTGSGKTLLAQTLAKCLDVPFAICDCTTLTQAGYVGEDIESVIAKLLQDANYNVEKAQQGIVFLDEVDKIGSVPGIHQLRDVGGEGVQQGLLKLLEGTIVNVPEKNSRKLRGETVQVDTTNILFVASGAFNGLDRIISRRKNEKYLGFGTPSNMGKGRRAAAAADLANISGESNTHEDIEEKDRLLRHVEARDLIEFGMIPEFVGRLPVVVPLHSLDEKTLVRILTEPRNAVVPQYQALFSMDKCELNVTEDALKAIARLALERKTGARGLRSIMEKLLLEPMFEVPNSDIVCVEVDKDVVEGKKEPGYIRAPTKDSSEEEYDSGVEEDGWPRQADAAHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UFF0</accession>
    <name>A0A8C2UFF0_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">FA complementation group I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FANCI</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="Ensembl" id="ENSCJPT00005035417.1">
        <property type="protein sequence ID" value="ENSCJPP00005026124.1"/>
        <property type="gene ID" value="ENSCJPG00005020338.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000005855"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990391">
        <property type="term" value="C:DNA repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070182">
        <property type="term" value="F:DNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031398">
        <property type="term" value="P:positive regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd11720">
        <property type="entry name" value="FANCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026171">
        <property type="entry name" value="FANCI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029310">
        <property type="entry name" value="FANCI_HD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029312">
        <property type="entry name" value="FANCI_HD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029308">
        <property type="entry name" value="FANCI_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029305">
        <property type="entry name" value="FANCI_S1-cap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029315">
        <property type="entry name" value="FANCI_S2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029313">
        <property type="entry name" value="FANCI_S3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029314">
        <property type="entry name" value="FANCI_S4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21818">
        <property type="entry name" value="BC025462 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21818:SF0">
        <property type="entry name" value="FANCONI ANEMIA GROUP I PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14679">
        <property type="entry name" value="FANCI_HD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14680">
        <property type="entry name" value="FANCI_HD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14675">
        <property type="entry name" value="FANCI_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14674">
        <property type="entry name" value="FANCI_S1-cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14676">
        <property type="entry name" value="FANCI_S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14677">
        <property type="entry name" value="FANCI_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14678">
        <property type="entry name" value="FANCI_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FANCI solenoid 1 cap" evidence="2">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="FANCI solenoid 1" evidence="3">
        <location>
            <begin position="64"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="FANCI helical" evidence="7">
        <location>
            <begin position="286"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="FANCI solenoid 2" evidence="4">
        <location>
            <begin position="379"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="FANCI helical" evidence="8">
        <location>
            <begin position="556"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="domain" description="FANCI solenoid 3" evidence="5">
        <location>
            <begin position="807"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="domain" description="FANCI solenoid 4" evidence="6">
        <location>
            <begin position="1044"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1301"/>
            <end position="1338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005026124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1338" mass="149326" checksum="A67BDCDEC422D178" modified="2022-01-19" version="1">MAQRILQLAAQQNPDGLREALQGLSEAELGDMVTKQALRGRETAALLKGIFRGSPCSQQSGVLRRLQVYKHCVALVESGDLHVGKASEIIGLLMLEARQLPGHALAELATLFVEVIKGGSLSNGKSLELFSTVLTALSNSKESLAYGKGELNGEEFKKQLINTLCSSKYVHLCQLHLRFNRDIPLSGEELQFVVEKVLRMFSRLDLQEIPPLVYQLLLLSAKGSKKTVLEGIISFFNQLDKRQKEEQRVPQSADLEVATVPLDQLRHVEGTVILHIVSAINLDQDIGEELIKHLKTEQQKDPGKALCPFSVALLLSIAVKHRLQEQIFDFLKTSITRSCKDLQFLEASKFLQDLCPQQYDVTAVILEVVKNSAFGWDHVTQGLVDLGFNLMESYEPKKPFGGKAAETNLGLSKMPAQQACKLGASILLETFKVHEPIRSDILEQVLNRVLMKAASPVSHFIELLSNIVVSAPLVLQNSSSRVTETFDNLSFLPIDTVQGLLRAVQPLLKVSMSVRDSLILVLQKAIFSRQLDARKAAVAGFLLLLRNFKILGSLTSSQCSQAIGATQVQADVHACYNSAANEAFCLEILGSLRRCLSQQADVRLMLYEGFYDVLRRNSQLASSIMETLLSQIKQYYLPQPDLLPPLKLEGCIMAQGDQIFLQEPLAHLLCCIQHCLAWYKSTVHLCKGADEEEEEEEDVGFEQNFEEMLESVTRRMIKSELEDFELDKSADFSPSSGVGVKNNIYAIQVMGICEVLIEYNFSTGNFSKNRFEDVLGLFTCYNKLSEILKEKAGKNKSTLGNKIARSFLSMGFVSTLLTALFRDNAQSHEESLAVLRSSTEFLRYAVSVALQKVQQLEETGQTDGPDGQNPEKMFQNLCKITRVLLWRYTSIPTAVEESGKKKGKSISLLCLEGLLRIFNTMQQLYAARIPQFLQALDITDGDAEEADINVTEKAAFQIRQFQRCLVNQLSSGEDDFNSKETQLLITILSTLSKLLDPGSQQFLQFLTWTVKICKENALEDLSCCKGLLTLLFSLHVLYKSPVSLLRELAQDIHACLGDIDQDIEIESRSHFAIVNVKTAAPTVCLLVLGQADKVLEEVDWLIKRLTILGSDTSEDSTQASNQTQALEKGVILQLGTLLTVFHELVQTALPAGSCVDSLLRSLSKTYAILTSLIKHYIQACRSTSNTVPGRLEKLVKLSGSHLTPQCYSFITYVQNIHSESLSFAEEKKKKKKEDETAAISTVMAKVLRDTKPIPNLIFAIEQYEKFLIHLSKKSKVNLMQYMKLSTSRDFRINASMLDSVLQEQNTEDAENEPDNNQSSTTEQPDENQEPQKKRRRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UFK6</accession>
    <name>A0A8C2UFK6_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">High mobility group box 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">HMGB1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HMGB family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSCJPT00005035496.1">
        <property type="protein sequence ID" value="ENSCJPP00005026184.1"/>
        <property type="gene ID" value="ENSCJPG00005020423.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183120"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010858">
        <property type="term" value="F:calcium-dependent protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098761">
        <property type="term" value="P:cellular response to interleukin-7"/>
        <property type="evidence" value="ECO:0007669"/>
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    <dbReference type="GO" id="GO:0032392">
        <property type="term" value="P:DNA geometric change"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="P:endothelial cell chemotaxis"/>
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        <property type="term" value="P:endothelial cell proliferation"/>
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        <property type="term" value="P:eye development"/>
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        <property type="term" value="P:glycogen catabolic process"/>
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        <property type="term" value="P:lung development"/>
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    <dbReference type="GO" id="GO:0002281">
        <property type="term" value="P:macrophage activation involved in immune response"/>
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    <dbReference type="GO" id="GO:0030099">
        <property type="term" value="P:myeloid cell differentiation"/>
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        <property type="term" value="P:myeloid dendritic cell activation"/>
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        <property type="term" value="P:positive regulation of ERK1 and ERK2 cascade"/>
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        <property type="term" value="P:positive regulation of interferon-alpha production"/>
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        <property type="term" value="P:positive regulation of interferon-beta production"/>
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        <property type="term" value="P:positive regulation of interleukin-1 beta production"/>
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        <property type="term" value="P:positive regulation of monocyte chemotactic protein-1 production"/>
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        <property type="term" value="P:positive regulation of non-canonical NF-kappaB signal transduction"/>
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        <property type="term" value="P:positive regulation of sprouting angiogenesis"/>
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        <property type="term" value="P:positive regulation of toll-like receptor 4 signaling pathway"/>
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        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:positive regulation of tumor necrosis factor production"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:positive regulation of wound healing"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:regulation of nucleotide-excision repair"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:regulation of T cell mediated immune response to tumor cell"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:regulation of tolerance induction"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:response to glucocorticoid"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:transcription by RNA polymerase II"/>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="HMG-box_HMGB_rpt1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="High mobility group protein B1"/>
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        <property type="entry name" value="high mobility group protein B1"/>
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        <property type="entry name" value="High mobility group box domain"/>
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        <property type="entry name" value="HMG_box_dom_sf"/>
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    <dbReference type="InterPro" id="IPR017967">
        <property type="entry name" value="HMG_boxA_CS"/>
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        <property type="entry name" value="HMGB"/>
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        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN B1-LIKE 1-RELATED"/>
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        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
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    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="HMG_box_2"/>
        <property type="match status" value="1"/>
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    <dbReference type="PRINTS" id="PR00886">
        <property type="entry name" value="HIGHMOBLTY12"/>
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        <property type="entry name" value="HMG"/>
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        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="HMG_BOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="HMG box" evidence="10">
        <location>
            <begin position="9"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="HMG box" evidence="10">
        <location>
            <begin position="95"/>
            <end position="163"/>
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    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="8">
        <location>
            <begin position="9"/>
            <end position="79"/>
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    <feature type="DNA-binding region" description="HMG box" evidence="8">
        <location>
            <begin position="95"/>
            <end position="163"/>
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    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="145"/>
            <end position="202"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00008774"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005026184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="221" mass="25790" checksum="EE9F2BB6BEF4354A" modified="2022-01-19" version="1">MGKGDPKKPKGKMSAYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSSKEKGKFEDMAKADKLRYEKEMKNYVPPKGETKKKFKDPNAPKRPPSAFFLFCSEFRPKIKGEHPGLSIGDVAKKLGEMWNNLSDGEKQPYNNKAAKLKEKYEKDIAAYRAKGKVDAGKKVVAKAEKRKMKMKRKMMKMMKMMKKMRRKMMMMMKKTXKMRKMMVGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2UGW2</accession>
    <name>A0A8C2UGW2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">U3 small nucleolar RNA-associated protein 18 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">WD repeat-containing protein 50</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">UTP18</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the WD repeat UTP18 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015735730.1">
        <property type="nucleotide sequence ID" value="XM_015880244.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2UGW2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005037349.1">
        <property type="protein sequence ID" value="ENSCJPP00005027663.1"/>
        <property type="gene ID" value="ENSCJPG00005021417.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107322321"/>
    <dbReference type="KEGG" id="cjo:107322321"/>
    <dbReference type="CTD" id="51096"/>
    <dbReference type="GeneTree" id="ENSGT00440000033919"/>
    <dbReference type="OrthoDB" id="1935146at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000121">
        <property type="entry name" value="U3 small nucleolar RNA-associated protein 18 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045161">
        <property type="entry name" value="Utp18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18359:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 18 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18359">
        <property type="entry name" value="WD-REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="87"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="170"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00058527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00075773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005027663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="538" mass="60529" checksum="8FE53D1C0590B3A3" modified="2022-01-19" version="1">MRAVPRVVCAERPERTGRSKKMKMKMKVVKRVRLQHKDTAVQDEASHRARHLRAISSTTAAERELEELVFGDSIGADEDELLHRLGRNELNVAQSGTRPERSRESESEDEGTAGSHVKRPVWVDEEDEAEERIDMTHRYRRELMKSDADKILTKKKLKARLEEQFQQAMGGVPAWADRENRKKSKKAASDSESDEDDDLLCRTGNFISGSESLPRGILEMKNCLPANQERLADGKLSTVQFHPSAQVVLTAGRDRSVSLFQVDGIRNPKIQSIYLESFPIYKARFSADGEQVIATGTHHKMFYVYDMMGGSIIPVPQVRGMEEKFVKNFEVSPDGSFMLLTGMSGYLHLLSMKTKELISTMKVNGRTTACAFTSDSSKIYSYSKEGEVFIWDVRSRKCLHKFEDEGSLEGKCIAVSKNNQYVACGSVSGVVNLYTTDVCVKESHPKPVKAIMNLVTSATSVTFNPTTEILAVASNEADEAVKLVHIPSYTVFSNFPVFRRKQIYLTQSMDFSPRSGFFSIANNKGKALLFRLKHYSDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y4N8</accession>
    <name>A0A8C2Y4N8_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">EMAP like 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">EML5</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat EMAP family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSCJPT00005000409.1">
        <property type="protein sequence ID" value="ENSCJPP00005000204.1"/>
        <property type="gene ID" value="ENSCJPG00005000275.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156613"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000040">
        <property type="entry name" value="echinoderm microtubule-associated protein-like 6 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000042">
        <property type="entry name" value="echinoderm microtubule-associated protein-like 6 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000044">
        <property type="entry name" value="echinoderm microtubule-associated protein-like 6 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000024">
        <property type="entry name" value="Putative echinoderm microtubule-associated protein-like 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000035">
        <property type="entry name" value="Putative echinoderm microtubule-associated protein-like 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000037">
        <property type="entry name" value="Putative echinoderm microtubule-associated protein-like 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055442">
        <property type="entry name" value="Beta-prop_EML-like_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055439">
        <property type="entry name" value="Beta-prop_EML_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005108">
        <property type="entry name" value="HELP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050630">
        <property type="entry name" value="WD_repeat_EMAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13720:SF16">
        <property type="entry name" value="ECHINODERM MICROTUBULE-ASSOCIATED PROTEIN-LIKE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13720">
        <property type="entry name" value="WD-40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23409">
        <property type="entry name" value="Beta-prop_EML"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23414">
        <property type="entry name" value="Beta-prop_EML_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03451">
        <property type="entry name" value="HELP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="25"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="EML-like first beta-propeller" evidence="11">
        <location>
            <begin position="2"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="100"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="EML-like second beta-propeller" evidence="12">
        <location>
            <begin position="178"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="254"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="EML-like first beta-propeller" evidence="11">
        <location>
            <begin position="569"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="749"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="domain" description="EML-like second beta-propeller" evidence="12">
        <location>
            <begin position="851"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="1084"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="domain" description="EML-like first beta-propeller" evidence="11">
        <location>
            <begin position="1256"/>
            <end position="1527"/>
        </location>
    </feature>
    <feature type="domain" description="EML-like second beta-propeller" evidence="12">
        <location>
            <begin position="1547"/>
            <end position="1814"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="1547"/>
            <end position="1581"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="1623"/>
            <end position="1664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="460"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1126"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="465"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1131"/>
            <end position="1144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF23414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005000204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1819" mass="202391" checksum="625A9DDB64B87C44" modified="2022-01-19" version="1">MQIFDISWDLYQPNKLVSCGVKHIKFWSLCGNSLTPKRGVFGKTGDLQTILCLACARDEVTYSGALNGDIYVWKGINLVRTIQGAHAAGIFSMNACEEGFATGGRDGCVRLWDLNFKPITVIDLRETDQGYKGLSVRSVCWRGDHILVGTQDSEIFEIVVHERNKPFLIMQGHCEGELWALAVHPTKPLAMTGSDDRSVRIWSLIDHALIARCNMEEPIRCAAVSTDGIHLALGMKDGSFTVLRVRDMTEVVHIKDRKEAIHELKYSPDGNFLAVGSNDSSVDIYGVVQRYKKVGECIGSLSFITHMDWSSDSKYIQTNDGNGKRLFYRMPSGKEVTNKEELKGIQWASWTCVSGVEVNGIWPKYSDINDINSVDANFIGQVMVTADDYGIVKLFRYPCLRKGAKFKKYLGHSAHVTNVRWSHDHQWVVSIGGADHSVFQWKFVPDRKLKDSLHIAPQESLVDSNSDESDSDQSDVPELDSEIEQETQITYRRQVYKEDLPQLKEQCKEKRKSAASKRRERAPGNSIRLHFVHGYRGYDCRSNLFYTQTGEIVYHVAAVGVVYNRQQNTQRFYLGHDDDILCLAIHPLKDYVATGQVGRDSSIHIWDTETIKPLSVLKGYHQYGVCAVDFSADGKRLASVGIDDNHTIVLWDWKKGEKLSAVRGSKDKIFVVKINPYMPEKLITVGIKHLKFWRRAGGGLIGRKGCIGAMGRADTMMCAVYGWTEEMAFSGTSTGDVCIWRDVFLIKTVKAHDGPVFSMHALEKGFVTGGKDGVVALWDDTFERCLKTYAIKRAALAPGSKGLLLEDNPSIRAISLGHGHILVGTKNGEILEVDKSGPVTLLVQGHMEGEVWGLATHPHLPICATVSDDKTLRIWDLSPSHCMLAVRKLKKGGRCCCFSPDGKALAVGLNDGSFLIVNADTLEDLVSFQHRKDVISEIRFSPGAGKYLAVASCDNFVDIYNVMSSKRVGICKGASSYITHLDWDIRGKLLQVNTGAKEQLFFEAPRGKKQTIPTLEVEKIGWASWTSVLGSCCEGIWPIIGEVTDVTASCLTSDSKVLATGDDFGFVKLFRYPAKGKFGKFKRYVAHSTHVTNVRWTYDDSLLVTVGGADTSLMLWTYEMEGHRDSRQCDSEESDLDSEEDGGYDSDVTRENEINYTIKALSTNIRPMFGIKPHLQQKEPTLDERPPVSRALPQPEKLQTNNVGKKKRPIEDLILELVFGYRGKDCRNNVHYLNDGADVIYHTASIGILYNVATGSQSFYQEHNDDILCLTVNQHPKFTNIVATGQVGDSADMSATAPSIHVWDAMNKQTLSVLRCYHSKGVCSVSFSATGKLLLSVGLDPEHTITIWKWQEGAKIASRAGHNQRIFVAEFRPDSDTQFVSVGVKHVRFWTLAGRALLSKKGLLSSIEDARMQTMLSVAFGANNLTFTGTISGDVCVWKDHVLIRIVAKAHNGPVFTMYTTLRDGLIVTGGKERPSKEGGAVKLWDQELKRCRAFRLETGQITDCVRSVCRGKGKILVGTRNAEIIEVGEKNAACNILINGHMDGPIWGLATHPSRDFFLSAAEDGTVRLWDITEKKMLNKVSLGHAARTVCYSPEGDMVAIGMKNGEFIILLVTSLKIWGKKRDRRSAIQDIRFSPDSRYLAVGSSENAVDFYDLTLGPTLNRVSYCKDIPSFVIQMDFSADSCYLQVSTGSYKRQVYEVPSGKQLVDQALIDRITWATWTSVLGDEVIGIWSRHAEKADVNCACVSHSGINLVTGDDFGMVKLFDFPCPEKFAKHKRFLGHSAHLTNIRFTSGDRYVVSAGGDDCSLFIWKCVHMPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y5C2</accession>
    <name>A0A8C2Y5C2_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Vacuolar protein sorting-associated protein 28 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">VPS28</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the VPS28 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y5C2"/>
    <dbReference type="Ensembl" id="ENSCJPT00005002804.1">
        <property type="protein sequence ID" value="ENSCJPP00005001656.1"/>
        <property type="gene ID" value="ENSCJPG00005001705.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000007486"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1130:FF:000001">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 28 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007143">
        <property type="entry name" value="Vps28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017899">
        <property type="entry name" value="VPS28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037206">
        <property type="entry name" value="VPS28_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12937">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 28, ISOFORM 2 VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12937:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 28 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03997">
        <property type="entry name" value="VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140427">
        <property type="entry name" value="VPS28 C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51310">
        <property type="entry name" value="VPS28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="VPS28 C-terminal" evidence="8">
        <location>
            <begin position="140"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005001656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="237" mass="26739" checksum="BFC2F50B102789D2" modified="2022-01-19" version="1">MGLYGVSMGLHGSLCVSMGPYRSLWVSMVPYGSLWVSMGLYGSLCVSMGLYGPLWVPIGLYGSLLVSMCLYGSLWVSMGLYVSLWVPMGLYGSQCIKAPIKSPLPILTPPFPIYRYTAACSRLLVQFKAALKQVQGPELSNIDEFCRKFRLFITIMDKLRLEIRAMDEIQPDLRELLETMNRMSALPSDFEGRHHVLHWLQTLSSMSASDELDDNQVRQMLFDLESAYNAFNRCLHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y622</accession>
    <name>A0A8C2Y622_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein O-glucosyltransferase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">POGLUT1</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 90 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015735132.1">
        <property type="nucleotide sequence ID" value="XM_015879646.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y622"/>
    <dbReference type="Ensembl" id="ENSCJPT00005005666.1">
        <property type="protein sequence ID" value="ENSCJPP00005003145.1"/>
        <property type="gene ID" value="ENSCJPG00005003378.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107322048"/>
    <dbReference type="KEGG" id="cjo:107322048"/>
    <dbReference type="CTD" id="56983"/>
    <dbReference type="GeneTree" id="ENSGT00940000158283"/>
    <dbReference type="OrthoDB" id="202415at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035251">
        <property type="term" value="F:UDP-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035252">
        <property type="term" value="F:UDP-xylosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048318">
        <property type="term" value="P:axial mesoderm development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072359">
        <property type="term" value="P:circulatory system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060537">
        <property type="term" value="P:muscle tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048339">
        <property type="term" value="P:paraxial mesoderm development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045747">
        <property type="term" value="P:positive regulation of Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010470">
        <property type="term" value="P:regulation of gastrulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001756">
        <property type="term" value="P:somitogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF35">
        <property type="entry name" value="PROTEIN O-GLUCOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034797922" evidence="3">
        <location>
            <begin position="21"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="4">
        <location>
            <begin position="119"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005003145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="390" mass="45667" checksum="4E8DA1E867E95469" modified="2022-01-19" version="1">MERAALWGLLAAVAVWPSGAADGGSEDAKWKAITDQINRAVEVYKPCVKENCSCYQSVWKQDLAPFRSGISKETISDVVSRKLGTHYQIIKNKLYREHDCMFPARCSGVEHFIHGIINRLPDMEMVINVRDYPQVPKWMKPIIPVFSFSKTAEYSDIMYPAWTFWEGGPAVWPIYPTGLGRWDLMREDLRRSAEKWPWKKKISKGYFRGSRTSSERDPLILLSREDPELVDAEYTKNQAWKSEKDTLGKPPAKEIPLVDHCKYKYLFNFRGVAASFRLKHLFLCGSLVFHVGEEWLEFFYQQLKPWVHYIPVRSDLSDVRELLQFAKENDNIAQEIAERGRQFITEHLQMEDVSCYWEHLLSEYSQTLTYKVKRRKNYNEIASEWLKTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y6P0</accession>
    <name>A0A8C2Y6P0_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lebercilin LCA5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LCA5</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LCA5 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015714509.1">
        <property type="nucleotide sequence ID" value="XM_015859023.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y6P0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005007437.1">
        <property type="protein sequence ID" value="ENSCJPP00005004444.1"/>
        <property type="gene ID" value="ENSCJPG00005004400.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107312014"/>
    <dbReference type="KEGG" id="cjo:107312014"/>
    <dbReference type="CTD" id="167691"/>
    <dbReference type="GeneTree" id="ENSGT00560000077266"/>
    <dbReference type="OrthoDB" id="2123794at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032391">
        <property type="term" value="C:photoreceptor connecting cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042073">
        <property type="term" value="P:intraciliary transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026188">
        <property type="entry name" value="Lebercilin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028933">
        <property type="entry name" value="Lebercilin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16650">
        <property type="entry name" value="C21ORF13-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16650:SF10">
        <property type="entry name" value="LEBERCILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15619">
        <property type="entry name" value="Lebercilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lebercilin" evidence="5">
        <location>
            <begin position="103"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="381"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="434"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="496"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="565"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="643"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="115"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="434"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="498"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="573"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF15619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005004444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="683" mass="79538" checksum="A9E0A849CAC1247E" modified="2022-01-19" version="1">MGERVRSPDSEQDRRSDEDRNSDSYYSDEDNASHSSDRSPTLSYPSTSHEKQDHKTRASDSLMHYQATKKLGSKYAPSKRGTQWGLRSQSLTRDSPAKDIDLVTKRVLSARLLKINELRNELTELHIKLDELQKENRALRRLQHRQEKALNKFEDTENEISQLIAQHNNEIRILRERLRKSQERERATERRLKDSEDELYRTKTVLQKLKKLSADKHLAERDDLAKKLAYAESRLEESEKRIKDLEKNLELSGSSFQRELQLKKKKVLEAQDKNRALQEELLQLNQKLKEKERELDAKNIYANRMLKVSPKKGMDVIQRKKANNQNIKKGTQLTKGIQTSGRFSSVELPPESELDCGDAVDKKERILSRIEKELQNKEWKEQTDLLEQEQDREKEEKLKRVQEPQTSEERFQKLRDEWEKEECDKVEKESSFLLNKEDKTKMETEIHKPETETESSEMLEERRKSEFLLAKMNEIDRETQNVMNVKLASQTSFVNALRKSDSPEKKEKNGQMFEIPGKVTNGFPQEDSQEDATRTQGLKQRNLRTVDLSNELTFGSYVPSFGKVSGRPSWLNQKDDSSEENVKENADFHSKKEKKSNLMEQLFGSSASTILLPKSKDMKSFDIDWESSNALLDKNSKIKAKEDNDLFSEGRNLNRHRPQHGGSKPAFKTLGSLEDEIEEVVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y6Z4</accession>
    <name>A0A8C2Y6Z4_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Caveolae associated protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">CAVIN1</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <location evidence="1">Caveola</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CAVIN family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015741200.1">
        <property type="nucleotide sequence ID" value="XM_015885714.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y6Z4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005008286.1">
        <property type="protein sequence ID" value="ENSCJPP00005005044.1"/>
        <property type="gene ID" value="ENSCJPG00005004884.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107325151"/>
    <dbReference type="KEGG" id="cjo:107325151"/>
    <dbReference type="CTD" id="284119"/>
    <dbReference type="GeneTree" id="ENSGT00950000182910"/>
    <dbReference type="OrthoDB" id="8951679at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005901">
        <property type="term" value="C:caveola"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000147">
        <property type="term" value="P:positive regulation of cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009303">
        <property type="term" value="P:rRNA transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006363">
        <property type="term" value="P:termination of RNA polymerase I transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026752">
        <property type="entry name" value="Cavin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15240:SF3">
        <property type="entry name" value="CAVEOLAE-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15240">
        <property type="entry name" value="CAVIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15237">
        <property type="entry name" value="PTRF_SDPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="154"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="221"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="262"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005005044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="361" mass="41294" checksum="707D8B63BEAF0FEB" modified="2022-01-19" version="1">MEDTTLQIIEPPTASEASEEQIPEEPIKSDQINGVMVLTLLDKIIGAVDQIQLTQTQLEERQQEMDSAVVSIQGELTKLTKAHTTTSNTVNKMLEKVRKVSVNVKTVRQNLEKQAGQIKKLEANEAELLKRRNFKVMIYQDEVKLPSKLSISKSLKEGEKQEKEGEGEEVPAGEDHAEEDHIQLSSDEEVEIEEIIEESRAERIKRSGMKRVDDFKKAFSKEKMEKTKLKTKENLEKTRHNLEKTRHNLEKRMNKLGTKIVTNERREKMKTSRDKLRKSFTPDHTIYARSKTAVYKVPPFTFHVKKIREGEVEVKATELVEVGGEEGENSDLMRGESPEMHTLLEITEESDAVLVDKSDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y7A4</accession>
    <name>A0A8C2Y7A4_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 14">Hepatocyte growth factor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 14">Hepatopoietin-A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11 14">Scatter factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">HGF</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Activates MAPK signaling following TMPRSS13 cleavage and activation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Dimer of an alpha chain and a beta chain linked by a disulfide bond. Interacts with SRPX2; the interaction increases HGF mitogenic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the peptidase S1 family. Plasminogen subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015733869.1">
        <property type="nucleotide sequence ID" value="XM_015878383.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y7A4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005008551.1">
        <property type="protein sequence ID" value="ENSCJPP00005005229.1"/>
        <property type="gene ID" value="ENSCJPG00005005049.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107321440"/>
    <dbReference type="KEGG" id="cjo:107321440"/>
    <dbReference type="CTD" id="3082"/>
    <dbReference type="GeneTree" id="ENSGT00940000156019"/>
    <dbReference type="OrthoDB" id="41905at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042056">
        <property type="term" value="F:chemoattractant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060326">
        <property type="term" value="P:cell chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035729">
        <property type="term" value="P:cellular response to hepatocyte growth factor stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050673">
        <property type="term" value="P:epithelial cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048012">
        <property type="term" value="P:hepatocyte growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001889">
        <property type="term" value="P:liver development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051450">
        <property type="term" value="P:myoblast proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902042">
        <property type="term" value="P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901299">
        <property type="term" value="P:negative regulation of hydrogen peroxide-mediated programmed cell death"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050728">
        <property type="term" value="P:negative regulation of inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032715">
        <property type="term" value="P:negative regulation of interleukin-6 production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090201">
        <property type="term" value="P:negative regulation of release of cytochrome c from mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000573">
        <property type="term" value="P:positive regulation of DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032733">
        <property type="term" value="P:positive regulation of interleukin-10 production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051897">
        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060665">
        <property type="term" value="P:regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900744">
        <property type="term" value="P:regulation of p38MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014856">
        <property type="term" value="P:skeletal muscle cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00108">
        <property type="entry name" value="KR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd01099">
        <property type="entry name" value="PAN_AP_HGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000023">
        <property type="entry name" value="Hepatocyte growth factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000026">
        <property type="entry name" value="Hepatocyte growth factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.20.10:FF:000004">
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y7J5</accession>
    <name>A0A8C2Y7J5_COTJA</name>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="2" type="primary">DEPTOR</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
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                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="gene ID" value="ENSCJPG00005005492.1"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:protein serine/threonine kinase inhibitor activity"/>
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        <property type="term" value="P:autophagosome assembly"/>
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        <property type="term" value="P:cellular response to nutrient levels"/>
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        <property type="entry name" value="DEPTOR_DEP_2"/>
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        <property type="entry name" value="mTOR-Rac_regulators"/>
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        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22829">
        <property type="entry name" value="DEP DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22829:SF18">
        <property type="entry name" value="DEP DOMAIN-CONTAINING MTOR-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PDZ domain-like"/>
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    </dbReference>
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        <property type="entry name" value="Winged helix' DNA-binding domain"/>
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    </dbReference>
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        <property type="entry name" value="DEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEP" evidence="1">
        <location>
            <begin position="24"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="DEP" evidence="1">
        <location>
            <begin position="133"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005005807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="475" mass="54033" checksum="63A8629AD60D816B" modified="2022-01-19" version="1">MEEGMSSMQQKATELEHMAEVLLTGEQLRLRLHEEKVIKDRRHHLKTYPNCFVAKELIDWLIDHKEASDRETAIKLVQKLLDHSIIHHVCDEHKEFKDAKLFYRFRKDDGTFPLDNEVKVFMRGQRLYEKLMSSENTLLQAREEEGVKYERTFVASEFIDWLIQEGEATTRTEAEQLGRRLLEHGIIQHVSNKHHFMDSNLLYQCRMNFRRRRRLMELLTEKSRLVPESHDSPFCLRKQNHDNRKHTSFLSVSPTKEIKIVSAVRRSSMSSCGSSGYFSSSPTLSSSPPVLCNPKSVLKRPVTADELLMPGAPYVRKTFTIVGDAVGWGFVVRGSKPCHIQAVDPSGPAAAAGMKVRAQRGMLYCDVWASWGRSWAACTWTVGGTLVSWAECLSDVFIIIHFSCLPPSSCFIFSVLEVLHRITEWFGLDGSLRSASSTPLLWAAITFSRTGTPNVPYNLALKNSRGGKSSSHFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y887</accession>
    <name>A0A8C2Y887_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Tomoregulin-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Transmembrane protein with EGF-like and one follistatin-like domain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">TMEFF1</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="12">May interact with ST14.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the tomoregulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015710669.1">
        <property type="nucleotide sequence ID" value="XM_015855183.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y887"/>
    <dbReference type="Ensembl" id="ENSCJPT00005011777.1">
        <property type="protein sequence ID" value="ENSCJPP00005007642.1"/>
        <property type="gene ID" value="ENSCJPG00005006985.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107309972"/>
    <dbReference type="KEGG" id="cjo:107309972"/>
    <dbReference type="CTD" id="8577"/>
    <dbReference type="GeneTree" id="ENSGT00940000160714"/>
    <dbReference type="OrthoDB" id="328123at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141069">
        <property type="term" value="F:receptor ligand inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046597">
        <property type="term" value="P:host-mediated suppression of symbiont invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046718">
        <property type="term" value="P:symbiont entry into host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00104">
        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.30:FF:000051">
        <property type="entry name" value="LOW QUALITY PROTEIN: tomoregulin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000233">
        <property type="entry name" value="tomoregulin-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.30:FF:000002">
        <property type="entry name" value="tomoregulin-2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21632">
        <property type="entry name" value="REGULATORY PROTEIN ZESTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21632:SF3">
        <property type="entry name" value="TOMOREGULIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="10 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 15" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="9 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 18" id="KW-0732">Signal</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034811318" description="Tomoregulin-1" evidence="18">
        <location>
            <begin position="41"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="20">
        <location>
            <begin position="94"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="20">
        <location>
            <begin position="185"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="19">
        <location>
            <begin position="267"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="362"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="297"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00063182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00072083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00083173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005007642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="376" mass="40642" checksum="2FFB4A180EB48FAB" modified="2022-01-19" version="1">MVAESPAAARPPPRAGPPRGLCCASALLLLALSALPAVRASHPLPAGECQGGGKGKGGNCSELNVKESDVKVCDESSCKYGGVCKEEGDGLKCACQFQCHTNYIPVCGSNGDTYQNECFLRRAACKHQKEITMVSRGPCYSDNGSGSGEGEYEGSGTEVQRKHSKCGVCKYRAECDEDAENVGCVCNIDCSGYSFNPVCASDGSSYNNPCFVREASCLRQEQIDIRHLGHCSEADDTNAVGKKDDGMQYRPEVKDASDQREDIYIGNHIPCSESFNGYCIHGKCEFIYSTQKASCRCESGYTGQHCEKTDFSILYVVPSRQKLTHVLIAAIIGAVQIAIIVAIVMCITRKCPKNNRGRRQKQNLGHFTSDTSSRMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y8H9</accession>
    <name>A0A8C2Y8H9_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Collagen alpha-1(IX) chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">COL9A1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Structural component of hyaline cartilage and vitreous of the eye.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Heterotrimer of an alpha 1(IX), an alpha 2(IX) and an alpha 3(IX) chain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the fibril-associated collagens with interrupted helices (FACIT) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015714610.1">
        <property type="nucleotide sequence ID" value="XM_015859124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y8H9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005011999.1">
        <property type="protein sequence ID" value="ENSCJPP00005007836.1"/>
        <property type="gene ID" value="ENSCJPG00005007115.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107312063"/>
    <dbReference type="KEGG" id="cjo:107312063"/>
    <dbReference type="CTD" id="1297"/>
    <dbReference type="GeneTree" id="ENSGT00940000157935"/>
    <dbReference type="OrthoDB" id="6161718at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005594">
        <property type="term" value="C:collagen type IX trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030020">
        <property type="term" value="F:extracellular matrix structural constituent conferring tensile strength"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000105">
        <property type="entry name" value="Collagen type IX alpha 1 chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050149">
        <property type="entry name" value="Collagen_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048287">
        <property type="entry name" value="TSPN-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023:SF1113">
        <property type="entry name" value="COLLAGEN ALPHA-2(IX) CHAIN-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00210">
        <property type="entry name" value="TSPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0176">Collagen</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="8" id="KW-0379">Hydroxylation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034138663" description="Collagen alpha-1(IX) chain" evidence="14">
        <location>
            <begin position="24"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="domain" description="Thrombospondin-like N-terminal" evidence="15">
        <location>
            <begin position="50"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="264"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="782"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="269"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="364"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="379"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="432"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="489"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="561"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="601"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="637"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="790"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="804"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="826"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="851"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="886"/>
            <end position="898"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00054091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00063820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00074726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005007836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="920" mass="91621" checksum="62050B663E161143" modified="2022-01-19" version="1">MKSNWKITAFLYMCSFLGSFISATIQQQSRLPVILGARQRTDLCPTIRIGQDDLPGFDLISQFQIEKAASQGIVQRIVGSTALQVAYKLGPNVDFRLPTSAIYSNGLPDEYSFLTTFRMTGATLQKYWTIWQIQDSSGKEQVGVNLNGPMKSVEFSYKGVDGNLQTASFLHLPFLFDSQWHKLMISVEATSVTLFIDCIKVESLNIKPKGKISVDGFAVLGRLKNNPQISVPFEVQWMLIHCDPLRPQREGCGELPARISQTVIERGLPGPPGPPGPPGPPGVPGIDGIDGERGPNGPPGPPGPDGDDGKAGSPGLPGEPGADGLTGPDGSPGATGPKGQKGEPGPPGARGLPGKGLLGPPGPAGAAGLPGEVGRAGPPGDPGKRGPPGPPGPPGPRGTIGLQDGDPLCPNACPPGRPGHAGLMGMKGQKGSKGESGEPGKQGYKGEEGDQGPIGEVGAQGPPGILGVRGITGITGPKGNKGARGLDGDPGPQGLPGAPGDQGQRGPLGEEGPKGERGPQGTRGINGLPGPKGESGLPGVDGREGIPGMPGAKGEPGKPGAPGDTGPQGLPGLPGSPGMKGIPGPKGNRGPPGVPGLMGNSGKPGEQGPEGEAGPTGPRGPPGSRGEPGPAGPPGLPGKWGPQGDIGLPGLPGPPGLPGGKGDRGSAGEPGPKGEQGAPGSEGDAGEKGDLGDMGLPGAKGSVGNPGDPGSRGPEGSRGLPGMEGPRGAPGPRGLQGEQGAPGLPGSQGPAGKEPTDQHIKQVCMRVMQEQLSQLAASLRRPEFGAPGLPGRPGPPGAPGPPGENGFPGQLGPRGLPGLKGPPGEIGRKGPKGEAGERGERGFPGRGEKGLPGPRGLPGEPGKPSYGREGRDGVRGPPGVAGQPGIPGPPGPPGPPGYCEPSSCRMQAGQRAAGKNVKGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y8N0</accession>
    <name>A0A8C2Y8N0_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine protease HTRA2, mitochondrial</fullName>
            <ecNumber evidence="5">3.4.21.108</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">HTRA2</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of non-polar aliphatic amino-acids at the P1 position, with a preference for Val, Ile and Met. At the P2 and P3 positions, Arg is selected most strongly with a secondary preference for other hydrophilic residues.</text>
            <dbReference type="EC" id="3.4.21.108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase S1C family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.108" evidence="5"/>
    <dbReference type="RefSeq" id="XP_032297470.1">
        <property type="nucleotide sequence ID" value="XM_032441579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y8N0"/>
    <dbReference type="Ensembl" id="ENSCJPT00005012870.1">
        <property type="protein sequence ID" value="ENSCJPP00005008507.1"/>
        <property type="gene ID" value="ENSCJPG00005007583.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107306835"/>
    <dbReference type="CTD" id="27429"/>
    <dbReference type="GeneTree" id="ENSGT00940000155108"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035631">
        <property type="term" value="C:CD40 receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905370">
        <property type="term" value="C:serine-type endopeptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030291">
        <property type="term" value="F:protein serine/threonine kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990948">
        <property type="term" value="F:ubiquitin ligase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007628">
        <property type="term" value="P:adult walking behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071363">
        <property type="term" value="P:cellular response to growth factor stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035458">
        <property type="term" value="P:cellular response to interferon-beta"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071300">
        <property type="term" value="P:cellular response to retinoic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030900">
        <property type="term" value="P:forebrain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008630">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to DNA damage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905090">
        <property type="term" value="P:negative regulation of type 2 mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048666">
        <property type="term" value="P:neuron development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900119">
        <property type="term" value="P:positive regulation of execution phase of apoptosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001241">
        <property type="term" value="P:positive regulation of extrinsic apoptotic signaling pathway in absence of ligand"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040014">
        <property type="term" value="P:regulation of multicellular organism growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd06785">
        <property type="entry name" value="cpPDZ_HtrA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.120:FF:000004">
        <property type="entry name" value="Serine protease HTRA2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22939">
        <property type="entry name" value="SERINE PROTEASE FAMILY S1C HTRA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22939:SF127">
        <property type="entry name" value="SERINE PROTEASE HTRA2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13365">
        <property type="entry name" value="Trypsin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0720">Serine protease</keyword>
    <keyword evidence="12" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="16" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="PDZ" evidence="17">
        <location>
            <begin position="335"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005008507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="403" mass="43079" checksum="E2D8F5437646622F" modified="2022-01-19" version="1">MAALCRWLRAPPVATRWGRAMCVSAANPRPPPPPPPSCPAPPGGHRLLAAALGAGTAALLLLWCREGRRPALLAAVPAPPAPPPGSPRAAFNFIADVVEKTAPALVYVEIVGRHPFSGREVPISNGSGFVVSPDGLIVTNAHVVANRRRVRVKLASGEQYDAVVQDVDQVADIATIRIKPKHPLPTLPLGRSSEVRQGEFVVAMGSPFALQNTITSGIVSSAQRGSRELGLTASDMEYIQTDAAIDFGNSGGPLVNLDGEVIGVNTMKVTSGISFAIPSDRLRKFLQKEEQRKSSWFGNAETKRRYIGVMMLTLTPSILAELKLRDPSFPDVSYGVLIHKVIIGSPAHQAGLKAGDVVLEINGQATRRAEDVYEAVRTQQSLALLVRRSYDTLLVSVVPEVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2Y9L6</accession>
    <name>A0A8C2Y9L6_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial fission regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MTFR2</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the MTFR1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2Y9L6"/>
    <dbReference type="Ensembl" id="ENSCJPT00005015066.1">
        <property type="protein sequence ID" value="ENSCJPP00005010129.1"/>
        <property type="gene ID" value="ENSCJPG00005008870.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183215"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007972">
        <property type="entry name" value="Mtfr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14215:SF2">
        <property type="entry name" value="MITOCHONDRIAL FISSION REGULATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14215">
        <property type="entry name" value="PROTEIN OF UNKNOWN FUNCTION DUF729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05308">
        <property type="entry name" value="Mito_fiss_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034256890" description="Mitochondrial fission regulator" evidence="6">
        <location>
            <begin position="25"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="265"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="232"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU369053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005010129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="357" mass="39943" checksum="5FA6500D629F5368" modified="2022-01-19" version="1">MALLLHLVRSLLEYLGWPPEQVRAGRGWGAKEYGSTRSVVRRLGTILSLEPYPRPYFQVSDLWLYISFNSPSLADVLWVACDEGQAFARFRTELWRKEKNTAYCDLHPSTDSIPSVSKTTSQKGSLVHQAALQKISALEEELTFLRTQIATIVAAQTLGSIPSRKPFCFFSWLRSLLYYGSYPVPTMTSTPLSVSHNHFAIPSPPPLPSVAPSGVDASNSAIELIKQRRAARNSTSTTSDSADPQMKNVPSMMDVLKDLNKVQLRATERSPGGTPVSKPKKRRSSDWDPVALLTHALKQKFAHKYEEEDDSLDKENRSFDSSPFSSPEIPLVCFAHLSMVQPSSHYHCYHKPLNHIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YCL4</accession>
    <name>A0A8C2YCL4_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">ArfGAP with GTPase domain, ankyrin repeat and PH domain 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">AGAP1</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the centaurin gamma-like family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2YCL4"/>
    <dbReference type="Ensembl" id="ENSCJPT00005023480.1">
        <property type="protein sequence ID" value="ENSCJPP00005016761.1"/>
        <property type="gene ID" value="ENSCJPG00005013461.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154793"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08853">
        <property type="entry name" value="ArfGap_AGAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04103">
        <property type="entry name" value="Centaurin_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01250">
        <property type="entry name" value="PH_AGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000001">
        <property type="entry name" value="Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000178">
        <property type="entry name" value="Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000332">
        <property type="entry name" value="arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000199">
        <property type="entry name" value="Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051282">
        <property type="entry name" value="Arf-GAP_GTPase_ANK_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45819:SF1">
        <property type="entry name" value="ARF-GAP WITH GTPASE, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45819">
        <property type="entry name" value="CENTAURIN-GAMMA-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PH" evidence="15">
        <location>
            <begin position="620"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="domain" description="Arf-GAP" evidence="16">
        <location>
            <begin position="910"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="1069"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="174"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="541"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="680"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="772"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="180"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="549"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="596"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="696"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="779"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="799"/>
            <end position="809"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005016761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="1136" mass="124768" checksum="68460AF3CBAB0877" modified="2022-01-19" version="1">MYLLDSSEPPAAASPERMQRGTPQRKTVYRISVTMVKKELLGPDGGPEPAQRGRRGGGQPGSRSLPRAGLLLVEEEEGEEQEEGGEEKDRVPSPCGFRNFRTLSTGQLELGRLKVPRRSGEHGAAAGSPPAEVAGPGRSPRRQPGLLRRSFSFRQWSGGELLRARALGRVRRHSSSGCIPAPAAPSEDAAAPGSPPAEPPVAEKRNTLDVGEVLSKAEPLTELERWERSKSKNRTLDNSDLQRLSERLGREGTPGGHAAHEHRLLRFFSGIFARKDGTSTLFGTPHGRSPRGSFSRSRAYFSSLRRATADIESSSESIDGSPRKDAFVNSQEWTLSRSVPELKVGIVGNLASGKSALVHRYLTGTYVQEESPEGMWICGRFKKEIVVDGQSYLLLIRDEGGPPEAQFAMWVDAVIFVFSLEDEVSFQTVYHYYSRMANYRNTSEIPMVLVGTQDAISSSNPRVIDDARARKLSNDLKRCTYYETCATYGLNVERVFQDVAQKIVATRKKQQLSIGPCKSLPNSPSHSSVCSAQVSAVHISQTSNGGGSLSDYSSSVPSTPSTSQKELRIDVPPTANTPTPVRKQSKRRSNLFTSRKGSDPDKEKKVLESRTDSIGSGRAIPIKQGMLLKRSGKSLNKEWKKKYVTLCDNGVLTYHPSLHDYMQNVHGKEIDLLRTTVKVPGKRPPRATSACAPISSPKTNGLSKDMSSLHISPNSGNVTTSTSVSQMASGISLVSFNSRPDGMHQRSYSVSSADQWSEATVIANSGISSDTGLGDSVCSSPSISSTTSPKLDPPPSPHANRKKHRRKKSTSNFKADGLSGTAEAKRKAWKLNRVGSLRNIYSSSSTNTEEQEENFEFIIVSLTGQTWHFEATTYEERDAWVQAIESQILASLQSCESSKNKSRLTSQNEAMALQSIRNIRGNSHCVDCEAQNPDWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDDWPIELIKVMSSIGNELANSVWEESSQGHMKPSSDSTREEKERWIRAKYEQKLFLAPLQCLELSLGQHLLRATAEEDLRTVILLLAHGTREEVNETCGDGDGRTALHLACRKGNVVLVQLLIWVRHGAWHGTMGTVVPGHWLYKCGRQGRREVRAGARGEERRNGNFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YE19</accession>
    <name>A0A8C2YE19_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ankyrin repeat and SOCS box containing 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ASB3</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015712159.1">
        <property type="nucleotide sequence ID" value="XM_015856673.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YE19"/>
    <dbReference type="Ensembl" id="ENSCJPT00005027124.1">
        <property type="protein sequence ID" value="ENSCJPP00005019607.1"/>
        <property type="gene ID" value="ENSCJPG00005015881.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107310745"/>
    <dbReference type="KEGG" id="cjo:107310745"/>
    <dbReference type="CTD" id="51130"/>
    <dbReference type="GeneTree" id="ENSGT00940000159080"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.750.20">
        <property type="entry name" value="SOCS box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036036">
        <property type="entry name" value="SOCS_box-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158235">
        <property type="entry name" value="SOCS box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="9"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="78"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="111"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="145"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="178"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="211"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="6">
        <location>
            <begin position="458"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="513"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="531"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005019607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="544" mass="60701" checksum="422BF9A4FD581094" modified="2022-01-19" version="1">MDFTEAYSDRCSAVGLAAREGNAEVLQKLIGQGYSLDVPDNRGWMPIHEAAAHYSSKCLRLLINAAPSDNYIHSKTFEGMSALHLSARCGSLECVGVLLEAGVDPDQVTTESNTALFLAVENGHADVVRFLIQHGASVEGSHSWSGWNSLHQAAFQQHVEIMKILLDKRANIECKDDFGITPLFVAAQYGKLESLRTLISHGADVNCQAKDRATPLLIAAQEGHAKCVELLISEGADPNLYCNEDNWQLPIHAAAEMGHKNILELLIPITNRICDKGKGKVSPVYSAIYGGNKECLEMLLKEGYSPDAQECPTFSCRSPMCMIFQRKFFNLIDTLLNYGITLLGINLGYCLYHDKFALFRRFLKICCPLPSQQELPEFLSCAIKALDEYKEWLPYLLSAGFDPVNLLYRFWINSLGEDALNLILEFTNWKRLPPAVEEDLANYKEKFTWTPRSHFAVIPSLSHLCRLEIRSILGSERLRSDRFIRALPLPVCLQDDLLYLQLLRVSTVPGAEENLRHSEEGAPSAAASTSDHTENRDARNSPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YEE6</accession>
    <name>A0A8C2YEE6_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">SET domain containing 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">SETD5</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="Ensembl" id="ENSCJPT00005028248.1">
        <property type="protein sequence ID" value="ENSCJPP00005020471.1"/>
        <property type="gene ID" value="ENSCJPG00005016488.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157446"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000791">
        <property type="term" value="C:euchromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034967">
        <property type="term" value="C:Set3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046975">
        <property type="term" value="F:histone H3K36 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046974">
        <property type="term" value="F:histone H3K9 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050890">
        <property type="term" value="P:cognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016480">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902275">
        <property type="term" value="P:regulation of chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051963">
        <property type="term" value="P:regulation of synapse assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd19181">
        <property type="entry name" value="SET_SETD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.270.10:FF:000009">
        <property type="entry name" value="SET domain-containing protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044433">
        <property type="entry name" value="SETD5_SET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46462:SF1">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46462">
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YGF9</accession>
    <name>A0A8C2YGF9_COTJA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RNA/RNP complex-1-interacting phosphatase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Dual specificity protein phosphatase 11</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Phosphatase that interacts with RNA/RNP complex 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC107316047</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Possesses RNA 5'-triphosphatase and diphosphatase activities, but displays a poor protein-tyrosine phosphatase activity. In addition, has phosphatase activity with ATP, ADP and O-methylfluorescein phosphate (in vitro). Binds to RNA. May participate in nuclear mRNA metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer. May interact with SFRS7 and SFRS9/SRP30C.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C2YGF9"/>
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        <property type="protein sequence ID" value="ENSCJPP00005024770.1"/>
        <property type="gene ID" value="ENSCJPG00005019500.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107316047"/>
    <dbReference type="KEGG" id="cjo:107316047"/>
    <dbReference type="GeneTree" id="ENSGT00940000155847"/>
    <dbReference type="OrthoDB" id="428974at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004651">
        <property type="term" value="F:polynucleotide 5'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000064">
        <property type="entry name" value="RNA/RNP complex-1-interacting phosphatase homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051029">
        <property type="entry name" value="mRNA_Capping_Enz/RNA_Phosphat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367:SF24">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="13">
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            <end position="321"/>
        </location>
    </feature>
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            <begin position="800"/>
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            <begin position="36"/>
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    </feature>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00080235"/>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
    <sequence length="822" mass="94348" checksum="145FBD94C9343AD9" modified="2022-01-19" version="1">MSIPRMRPRALSARADAGPRPIGRLVTQPCGRSLESAGACPSARSRRAAPSLRAGRPPRMRSGDRVGKVECRPSRCSLALRGGSCPDARSFWLRRLVAVGARGLSRLLCSGSAWKIFTFAALLRELEACCLSSLVLLVSWRGECALSPLSPALPAPAFSMVKKNTIPEGWRSLTPVGQPIPGTRFIAFKVPLKGAINQRLTPTQKFTPKDLIAAMKALNVELGLIIDLTYTTRYYEVKDLPKSVQYKKLYTVGLEVPDNATILQFKKWVRKFLWENARNEKLIGVHCTNGINRTGYLICRYLIDVEGWDPEAAIQAFGDARGHCMDGLIYLTDLRTQPMRSNLGMDVWDSDEDIIPPPNATEGPVEQFPNEDFQGSGKRLRVYDDNSHNNLQGQTQLRDFDFVNKGPGRRRRPFHDHQTQDDLRAPMEMSNWDYNRGPGQRQGPFCDHQFYNDYREDVQLKDLDLSNKGPGQQLRPFYGHQFRGDLQTERPSRNSEFKRGRGQRQRFFRDCSSHSDSPEDMKSKDFGFSSRGRGQRQRHSHPSHDHFQAPMQLKELDCVNKGAGQRLRSFHDYQSHDDLQPQMQQEDFEFVNRGRGQRSRPFHCHQPHNDLHTEMHLKDYDNKGPRQRRRLFNDHQPYDDLQEQPQLKDFDYVNKGQGQKRSRPFHDHPVQDDVPREWCSDRNQSFSSHENVSEPQFTSSPSLHRDYGSDNDDFSRSYSNRASCPEDSRRVYPSDEFNKGKNRFAPYSSCAMHPSSSVHQEDGSLDYEIKTFKGETTREMEQGKRLPVVTVDYNYGLPLNYGPEEEERTPYDVPPRVQYSWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YGP9</accession>
    <name>A0A8C2YGP9_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Component of oligomeric golgi complex 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">COG6</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YGP9"/>
    <dbReference type="Ensembl" id="ENSCJPT00005034431.1">
        <property type="protein sequence ID" value="ENSCJPP00005025298.1"/>
        <property type="gene ID" value="ENSCJPG00005019873.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000013518"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000301">
        <property type="term" value="P:retrograde transport, vesicle recycling within Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010490">
        <property type="entry name" value="COG6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048369">
        <property type="entry name" value="COG6_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21506">
        <property type="entry name" value="COMPONENT OF OLIGOMERIC GOLGI COMPLEX 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21506:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20653">
        <property type="entry name" value="COG6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01087">
        <property type="entry name" value="COG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Conserved Oligomeric Golgi complex subunit 6 C-terminal" evidence="1">
        <location>
            <begin position="134"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCJPP00005025298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694412"/>
        </source>
    </evidence>
    <sequence length="586" mass="66617" checksum="9C69715DFAE6D94E" modified="2022-01-19" version="1">MFDVFFSMERRRLWGDLIVAFQYLKGAYKQEGEWLFMRVDSDGTRRNGFKLRQGRFRLDIRRKFFTQRVVTHWNRLPKEAVDAPSLEAFKARLDVAPGSLDWWLATLRIDFFKALGRVKQIHDDVKILLRTNQQRAGLEIMEQMALLQETSYERLYRWTQNECRTLTQESCDISPVLAQAMEALQDRPVLYKYTLDEFGTARRSAVVRGFIDALTRGGLGGTPRPIEMHSHDPLRYVGDMLAWLHQATASEKEHLEAILKLVTIEGVEENIQEVVGHITEGVCRPLKVRIEQVIVAEPGAVLLYKISNLLKFYHHTISAIVGNSAATLLTTIEEMHLLSKKIFFNSLSLHASKLMDKVELPPPDLGPSSALNQTLNLLREVLASHDSSVVPLDARQADFVQVLSCVLDPLLQMCTMSASNLGTADMATFMVNSLYMMKTTLALFEFTDKRLEMLQFQIEAHLDTLINEQASYVLTRAGLSYIYNSVQQHKPEQGPLSNLPSLDSMSLKVAMAQFDRYLSAPDSLLMSQLNFLLSATVKEQIIKQSTELVCRAYSEIYAAVMDPSNKYKDPETILHRSPHQVQALLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2YH72</accession>
    <name>A0A8C2YH72_COTJA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Transmembrane protein 163</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">TMEM163</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coturnix japonica</name>
        <name type="common">Japanese quail</name>
        <name type="synonym">Coturnix coturnix japonica</name>
        <dbReference type="NCBI Taxonomy" id="93934"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Dinosauria</taxon>
            <taxon>Saurischia</taxon>
            <taxon>Theropoda</taxon>
            <taxon>Coelurosauria</taxon>
            <taxon>Aves</taxon>
            <taxon>Neognathae</taxon>
            <taxon>Galloanserae</taxon>
            <taxon>Galliformes</taxon>
            <taxon>Phasianidae</taxon>
            <taxon>Perdicinae</taxon>
            <taxon>Coturnix</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="International Coturnix japonica Genome Analysis Consortium"/>
                <person name="Warren W."/>
                <person name="Burt D.W."/>
                <person name="Antin P.B."/>
                <person name="Lanford R."/>
                <person name="Gros J."/>
                <person name="Wilson R.K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Secretory vesicle</location>
            <location evidence="2">Synaptic vesicle membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Early endosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TMEM163 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_015724376.1">
        <property type="nucleotide sequence ID" value="XM_015868890.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2YH72"/>
    <dbReference type="Ensembl" id="ENSCJPT00005035603.1">
        <property type="protein sequence ID" value="ENSCJPP00005026285.1"/>
        <property type="gene ID" value="ENSCJPG00005020455.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107316879"/>
    <dbReference type="KEGG" id="cjo:107316879"/>
    <dbReference type="CTD" id="81615"/>
    <dbReference type="GeneTree" id="ENSGT00390000001170"/>
    <dbReference type="OrthoDB" id="5980560at2759"/>
    <dbReference type="Proteomes" id="UP000694412">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042552">
        <property type="term" value="P:myelination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140882">
        <property type="term" value="P:zinc export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026765">
        <property type="entry name" value="Tmem163"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31937">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31937:SF2">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            
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